title: Controversies regarding surfactant replacement therapy.
abstract: Surfactant replacement therapy for the respiratory distress syndrome is being actively studied in clinical trials. The therapy has great potential for reducing morbidity and mortality in premature infants. Some issues about surfactant replacement therapy are not yet clear, and a number of these are discussed in this article.
authors.affiliation: Department of Pediatrics (Neonatology), University of Rochester School of Medicine, New York.
authors.forename: D L
authors.initials: DL
authors.lastname: Shapiro
authors.forename: R H
authors.initials: RH
authors.lastname: Notter
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008170:Lung Compliance; D008176:Lung Volume Measurements; D011663:Pulmonary Surfactants / Q000008:administration & dosage* / Q000009:adverse effects; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*
chemical_list: D011663:Pulmonary Surfactants