title: The effect of intranasally administered nitroglycerin on the blood pressure response to laryngoscopy and intubation in patients undergoing coronary artery by-pass surgery.
abstract: The effect of intranasally administered nitroglycerin (NTG) on the cardiovascular response to laryngoscopy and intubation was studied. Thirty patients scheduled to undergo coronary artery by-pass surgery under thiopentone, enflurane and pancuronium anaesthesia were randomly divided into three groups. Group I received lignocaine 1.5 mg/kg i.v. prior to laryngoscopy and intubation (control group). Group II received lignocaine 1.5 mg/kg i.v. and in addition 2 mg nitroglycerin (NTG) was given intranasally. Group III received only 2 mg NTG intranasally. In Group I laryngoscopy and intubation caused a significant increase in mean arterial pressure (MAP) (P less than 0.01), heart rate (HR) (P less than 0.01) and rate pressure product (RPP) (P less than 0.01) compared to preoxygenation values. In Group II and III MAP and RPP remained unchanged, whereas HR increased (P less than 0.01 and P less than 0.01 respectively). It can be concluded that intranasally administered NTG effectively attenuates the pressor response to laryngoscopy and intubation in patients presenting for coronary artery by-pass surgery and that it is more effective and convenient method than intravenous lignocaine.
authors.forename: J
authors.initials: J
authors.lastname: Dich-Nielsen
authors.forename: P
authors.initials: P
authors.lastname: Hole
authors.forename: T
authors.initials: T
authors.lastname: Lang-Jensen
authors.forename: A
authors.initials: A
authors.lastname: Owen-Falkenberg
authors.forename: P
authors.initials: P
authors.lastname: Skovsted
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000368:Aged; D000758:Anesthesia; D001794:Blood Pressure / Q000187:drug effects*; D001026:Coronary Artery Bypass; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007440:Intubation; D007828:Laryngoscopy; D008012:Lidocaine / Q000627:therapeutic use; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D008012:Lidocaine; D005996:Nitroglycerin