title: Mechanisms of central conduction time prolongation in brain-stem auditory evoked potentials.
abstract: The wave I-wave V delay in the auditory brain-stem response is commonly used as a diagnostic tool in otoneurology. Normative values have been established for different populations and different types of stimuli. This I-V delay has been known for some time as "central conduction time" or "central transmission time." This implies that the measure reflects in normal and in pathologic cases delays due to nerve conduction, synaptic transmission, and neural integration and is not caused by cochlear processes. By virtue of the traveling wave delay in the cochlea, amounting to some 4 ms from the base to the "500-Hz place," it is conceivable that this delay contributes to the I-V delay. From a series of 69 pontine angle tumors in which the auditory brain-stem response was recorded, we selected cases with an apparent peripheral origin of a prolonged I-V delay by comparing the whole-click response to responses derived from high-pass noise masking. It seems that cases with an increased I-V delay in the whole-click response but (almost) normal I-V delays in the narrow-band response are indicative of small intracanalicular acoustic neuroma.
authors.forename: J J
authors.initials: JJ
authors.lastname: Eggermont
authors.forename: M
authors.initials: M
authors.lastname: Don
mesh_terms: D001933:Brain Stem / Q000503:physiopathology*; D002784:Cholesterol; D003389:Cranial Nerve Diseases / Q000175:diagnosis / Q000503:physiopathology; D003390:Cranial Nerve Neoplasms / Q000175:diagnosis* / Q000503:physiopathology; D005072:Evoked Potentials, Auditory; D006099:Granuloma / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D009431:Neural Conduction; D009456:Neurofibromatosis 1 / Q000175:diagnosis* / Q000503:physiopathology; D009464:Neuroma, Acoustic / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D002784:Cholesterol