[The development of heart failure during transvalvular catheterization of the left ventricle in spontaneously hypertensive rats].
Systemic hemodynamic parameters in 5-month-old and 10-month-old normotensive Wistar-Kyoto and spontaneously hypertensive (SHR) conscious rats were studied with microsphere technique. Cardiac index was similar in both strains of rats and was not significantly different between 5 and 10 months. Left ventricle catheter implantation through the right common carotid artery evoked the development of heart failure in 10-month-old SHR (in the first day after operation). This model can be used for screening of new drugs for heart failure treatment.
Dugin
S F
SF
Gorodetskaia
E A
EA
Medvedev
O S
OS
Murashev
A N
AN
D000375:Aging / Q000502:physiology; D000818:Animals; D006328:Cardiac Catheterization / Q000009:adverse effects* / Q000379:methods; D006333:Heart Failure / Q000209:etiology* / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology; D006439:Hemodynamics; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D008863:Microspheres; D011865:Radioisotope Dilution Technique; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
Razvitie serdechnoĭ nedostatochnosti pri transklapannoĭ kateterizatsii levogo zheludochka u spontanno-gipertenzivnykh krys.