[Protective effect of antioxidant ionol in total ischemia of the heart].
The effect of antioxidant ionol in total myocardial ischemia during 30 and 60 min, t = 20 degrees C and 37 degrees C was studied in 60 Wistar rats. The models of isolated perfused myocardium by Langendorf, Neely and that of heterotopic transplantation of myocardium to the rat peritoneal vessels were used. It has been shown that pretreatment of ionol (240 mg/kg before 24 h of ischemia) was accompanied by improvement of myocardial contractile and diastolic functions.
Bilenko
M V
MV
Otverchenko
V N
VN
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006324:Heart Arrest, Induced; D016027:Heart Transplantation; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D015425:Myocardial Reperfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000975:Antioxidants; D002084:Butylated Hydroxytoluene
Zashchitnyĭ éffekt antioksidanta ionola pri total'noĭ ishemii serdtsa.