title: Malignant transformation in trophic ulcers in leprosy: a study of 12 cases.
abstract: Twelve cases of carcinomata arising in Trophic ulcers of Leprosy are presented. Out of these, 10 were on the plantar surface more commonly on the proximal part of foot, one on lower leg and dorsum of foot, and one in an ulcer over the lateral malleolus. Almost all presented with infected growths and regional lymphadenopathy. Three cases presented with advanced disease with fungating inguinal nodes and were fatal. Nine cases underwent below knee amputation under antibiotic cover as a definitive treatment and the lymph nodes were kept under observation. Histologically, all were low grade squamous cell carcinomas. In most cases lymph nodes regressed after removal of primary and in one case lymph nodes were positive for malignancy. This study was conducted at Dr. Bandorawalla Leprosy Hospital, Kondhawa, Pune 22 from the year 1981 to 1987.
authors.affiliation: Dr. Bandorawalla Leprosy, Hospital, Kondhawa, Pune.
authors.forename: S B
authors.initials: SB
authors.lastname: Sane
authors.forename: J M
authors.initials: JM
authors.lastname: Mehta
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D005260:Female; D005534:Foot Diseases / Q000473:pathology; D006801:Humans; D007871:Leg Ulcer / Q000178:diet therapy / Q000473:pathology*; D015439:Leprosy, Borderline / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology*