[Simulation of the initiation of pseudotuberculosis infection].
A decrease in the temperature of the cultivation of Yersinia pseudotuberculosis has been shown to lead to the appearance of motility and adhesive properties in these bacteria, to enhance their ability to penetrate the body of the host through mucous membranes, while a rise in the temperature of cultivation has been shown to cause the loss of these properties and, therefore, a decrease in the penetrating capacity of these bacteria. Y. pseudotuberculosis penetrates from the surface of the epithelium into the blood stream in 10 minutes. The capacity of the bacteria penetrating into the blood to induce lethal infection is determined, to a great extent, by the plasmid calcium dependence, and in oral infection, when these bacteria must overcome the barrier formed by the mucous membrane, calcium-dependent bacteria grown at 6-8 degrees C show the highest degree of virulence.
Timchenko
N F
NF
Venediktov
V S
VS
Pavlova
T N
TN
D002448:Cell Adhesion; D002465:Cell Movement; D006367:HeLa Cells; D006801:Humans; D008954:Models, Biological; D013696:Temperature; D014774:Virulence; D015011:Yersinia pseudotuberculosis / Q000472:pathogenicity*; D015012:Yersinia pseudotuberculosis Infections / Q000209:etiology
Modelirovanie initsiatsii psevdotuberkuleznoĭ infektsii.