Sodium citrate: a promoter of bladder carcinogenesis.
Dietary administration of 5% sodium citrate to male F344 rats clearly promoted the induction of preneoplastic and neoplastic lesions of the bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Enhancement of tumorigenesis by sodium citrate was associated with changes in a number of urinary parameters: apparent elevation of pH; increase of sodium ion concentration; increase of crystalline MgNH4PO4. These results show that sodium citrate promotes bladder carcinogenesis.
Fukushima
S
S
Thamavit
W
W
Kurata
Y
Y
Ito
N
N
D000818:Animals; D002085:Butylhydroxybutylnitrosamine; D002951:Citrates / Q000633:toxicity*; D019343:Citric Acid; D003043:Cocarcinogenesis; D006863:Hydrogen-Ion Concentration; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012964:Sodium / Q000652:urine; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002951:Citrates; D019343:Citric Acid; D002085:Butylhydroxybutylnitrosamine; D012964:Sodium