[Derivatives of phenoxyacetamide and antimycotic activity].
Novel N-(3-methyl-4-R-isoxazol-5-yl)-2-R1-4-R2-phenoxyacetamides and N-(3-methyl-4-R-isoxazol-5-yl)-2-(2-R1-4-R2-phenoxyacetamido) benzamides were prepared and tested against Candida albicans and Cryptococcus neoformans. The results of the antimicrobial assay showed that the presence of two amidic groups usually enhances antimycotic activity.
Daidone
G
G
Dipartimento di Chimica e Tecnologie Farmaceutiche, Universita di Palermo.
Raffa
D
D
Bajardi
M L
ML
Plescia
S
S
Milici
M
M
D000081:Acetamides / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis*; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000081:Acetamides; D000935:Antifungal Agents
Derivati della fenossiacetammide ad attività antimicotica.