T-lymphocyte subpopulation changes during hemolysis in glucose-6-phosphate dehydrogenase (G6PD)-deficient children.
Lymphocyte subpopulations were studied by means of sheep red blood cell (SRC)-rosetting technique and OKT11, OKT3, OKT4, and OKT8 monoclonal antibodies in ten Sicilian glucose-6-phosphate dehydrogenase-deficient children during the hemolytic crisis due to fava bean ingestion. The number of SRC-rosetting lymphocytes was significantly reduced, while the number of OKT3-positive cells was normal. An inversion of the OKT4/OKT8 ratio was observed, due to a decrease of OKT4-positive cells and an increase of OKT8-positive cells. All these abnormalities reverted to normal in the four children studied after recovery.
Schilirò
G
G
Minniti
C
C
Sciotto
A
A
Bellino
A
A
Russo
A
A
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000032:analysis; D002675:Child, Preschool; D005236:Favism / Q000097:blood* / Q000276:immunology; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood* / Q000276:immunology; D006461:Hemolysis; D006801:Humans; D007223:Infant; D008297:Male; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000145:classification*
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface