title: Effects of contrast media on the conducting system of the heart during coronary angiography. A comparison of Renografin-76 to Hypaque-76.
abstract: Electrocardiographic changes induced by ionic contrast media can cause complications during coronary angiography. A conduction delay through various parts of the heart is one factor in the genesis of asystole or ventricular fibrillation. Hypaque-76 (H76) and Renografin-76 (R76) are nearly identical ionic contrast media except that R76 binds more calcium than H76 because of the presence of sodium citrate and EDTA in R76. To determine whether the calcium binding additives in ionic contrast media contribute to the cardiac conduction abnormalities, we examined conduction time through the atrioventricular (AV) nodal tissue (via bipolar His bundle electrograms) and through the distal part of the conduction system (recording the QRS complex from the ECG) during coronary angiography. We injected 10 mL of H76 and R76 in 19 closed chest dogs in a blinded, randomized fashion during coronary angiography. The effects of H76 and R76 on heart rate, AH interval, HV interval, V interval and PR interval, and QRS complex duration were recorded. In 14 nonatrial pacing dogs, compared with H76, R76 produced a greater increase in the AV interval (32.9 +/- 6 milliseconds vs 12.4 +/- 2 milliseconds, P less than .01) and the PR interval (29.6 +/- 6 milliseconds vs 11.9 +/- 4 milliseconds, P less than .02). Additionally, the heart rate decreased 13.9 +/- 3.5 beats/minute from control with R76 compared with a decrease of 4.2 +/- 2.6 beats/minute from control with H76 (P less than .05). There was no significant difference between the prolongation of the HV interval and V interval, or QRS complex duration generated by R76 and H76.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, Loyola University Medical Center, Maywood, Illinois.
authors.forename: M H
authors.initials: MH
authors.lastname: Hwang
authors.forename: Z E
authors.initials: ZE
authors.lastname: Piao
authors.forename: D K
authors.initials: DK
authors.lastname: Murdock
authors.forename: H S
authors.initials: HS
authors.lastname: Loeb
authors.forename: R M
authors.initials: RM
authors.lastname: Raymond
authors.forename: P J
authors.initials: PJ
authors.lastname: Scanlon
mesh_terms: D000792:Angiography; D000818:Animals; D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000633:toxicity*; D017023:Coronary Angiography; D003973:Diatrizoate / Q000633:toxicity*; D003974:Diatrizoate Meglumine / Q000633:toxicity*; D004285:Dogs; D004338:Drug Combinations / Q000633:toxicity; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D008297:Male; D011897:Random Allocation
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; C027278:urovision