Endogenous opiates do not influence glucose and lipid metabolism in rat adipocytes.
The effects of the opiates beta-endorphin, dynorphin, met-enkephalin, leu-enkephalin, morphine and of the opiate-antagonist naloxone on glucose metabolism and lipolysis were studied in isolated rat adipocytes. None of the tested substances was found to alter 125I-Insulin binding. The opiates did not influence 2-deoxy-glucose uptake or glucose incorporation into lipids. They also did not exhibit a lipolytic activity. We conclude that the disturbances of glucose homeostasis induced by endogenous opiates are not mediated by an effect on peripheral glucose metabolism.
Hauner
H
H
Department of Internal Medicine I, Universität Ulm, FRG.
Glatting
G
G
Ditschuneit
H H
HH
Pfeiffer
E F
EF
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D003847:Deoxyglucose / Q000378:metabolism; D004723:Endorphins / Q000494:pharmacology*; D004822:Epididymis / Q000187:drug effects / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism; D050356:Lipid Metabolism; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D004723:Endorphins; D007328:Insulin; D009270:Naloxone; D009020:Morphine; D003847:Deoxyglucose; D005947:Glucose