Autocrine or paracrine models of cytokine production and utilization in B-cell chronic lymphocytic leukaemia.
The possibility that autocrine or paracrine mechanisms of cytokine production and utilization may take place in patients with B-cell chronic lymphocytic leukaemia (B-CLL) is discussed. In particular, evidence is provided for a likely role of interleukin 2 (IL2) on the neoplastic B-cell compartment. Furthermore, the possibility that tumor necrosis factor (TNF) may also be involved is suggested.
Foa
R
R
Dipartimento di Scienze Biomediche e Oncologia Umana, University of Torino, Italy.
Giovarelli
M
M
Fierro
M T
MT
Bonferroni
M
M
Forni
G
G
D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000502:physiology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism*; D008954:Models, Biological; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000502:physiology
D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha