title: [Gonadotropic activity of the hypophysis and ovarian endocrine function in hyperprolactinemic amenorrhea].
abstract: Radioimmunoassays were used repeatedly to determine prolactin, LH, FSH, estradiol and progesterone at different time intervals (days, months, weeks) in 50 women with hyperprolactinemic amenorrhea. Nine patients had x-ray signs of hypophysial adenoma. The intact state of the portal system, hypophysis gonadotrophs and thyrotrophs was confirmed using LH-RH and TRH tests. Proceeding from the comparison of gonadotrophin and sex steroids and the analysis of the blood LH fluctuation amplitude after repeated measurements, it was concluded that the gonadotropic basal secretion was disturbed in hyperprolactinemic amenorrhea and that a single determination of an elevated gonadotrophin level in the blood was not enough to diagnose primary ovarian insufficiency.
authors.forename: A V
authors.initials: AV
authors.lastname: Isakov
authors.forename: V V
authors.initials: VV
authors.lastname: Potin
authors.forename: F A
authors.initials: FA
authors.lastname: Svechnikova
authors.forename: T D
authors.initials: TD
authors.lastname: Iumatova
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000097:blood*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood*; D007247:Infertility, Female / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D010053:Ovary / Q000378:metabolism*; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013997:Time Factors
chemical_list: D006065:Gonadotropins, Pituitary; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin
vernacular_title: Gonadotropnaia aktivnost' gipofiza i éndokrinnaia funktsiia iaichnikov pri giperprolaktinemicheskoĭ amenoree.