title: Sociodemographic and prior clinical course characteristics associated with treatment response in depressed patients.
abstract: A sociodemographic and clinical picture is presented of 82 depressed subjects who had an unequivocal response or lack of response to treatment with amitriptyline or imipramine. Patients with less severe depressive illness were found more likely to respond to treatment, while those with psychotic features were more likely to be treatment resistant. Sociodemographic and other prior and current clinical course variables were not predictive of treatment response in depressed patients.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110.
authors.forename: J L
authors.initials: JL
authors.lastname: Croughan
authors.forename: S K
authors.initials: SK
authors.lastname: Secunda
authors.forename: M M
authors.initials: MM
authors.lastname: Katz
authors.forename: E
authors.initials: E
authors.lastname: Robins
authors.forename: J
authors.initials: J
authors.lastname: Mendels
authors.forename: A
authors.initials: A
authors.lastname: Swann
authors.forename: B
authors.initials: B
authors.lastname: Harris-Larkin
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011581:Psychological Tests; D011897:Random Allocation; D012917:Social Adjustment; D012959:Socioeconomic Factors
chemical_list: D000639:Amitriptyline; D007099:Imipramine