[Isosorbide dinitrate: correlations between its anti-anginal effect, dosage form and administration schedule].
The action of various dosage forms of isosorbide dinitrate (ID) was studied with the help of repeated treadmill run in 28 CHD patients with stable angina of effort. The mean duration of the antianginal effect of ID standard tablets (nitrosorbide-NS) at a dose of 10 mg per os was 3.0 +/- 0.4 h. The effect of sublingual NS administration was more marked and the duration slightly less than in NS administration per os. ID of prolonged action isomac-retard containing 40 mg of ID produced an effect, insignificantly exceeding in duration the NS effect. Dinitrosorbilong (DNL) for gingival application produced and effect as marked as that of sublingual NS. The duration of the DNL effect significantly exceeded that of the effect of all ID dosage form under study (over 8 h). An increase in a NS dose per os did not result in an effect of the same degree and duration as that of DNL.
Martsievich
S Iu
SIu
Metelitsa
V I
VI
D000278:Administration, Buccal; D000284:Administration, Oral; D000286:Administration, Sublingual; D000787:Angina Pectoris / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000627:therapeutic use*; D010919:Placebos
D010919:Placebos; D007548:Isosorbide Dinitrate
Izosorbid dinitrat: zavisimost' antianginal'nogo éffekta ot lekarstvennoĭ formy i dozy preparata.