title: Hyperinsulinuria in diabetic ketoacidosis.
abstract: Urinary insulin excretion has been measured in diabetic children. In nine well controlled diabetics urinary insulin excretion (mean and 2SD) was significantly greater than that found in healthy controls (8.8; 4.4-17.5 versus 3.8; 2.3-6.4 microU/min/1.73 m2). In ten ketoacidotic diabetic children a 50 fold increase of the urinary insulin excretion has been observed (464.8; 158.2-1363 microU/min/1.73 m2). The hyperinsulinuria proved to be reversible: significantly decreased excretion rate (12.9; 9.7-12.3) could be measured 8-10 days after recovery from coma. The hyperinsulinuria during ketoacidosis indicates severe reversible tubular dysfunction. Recurrent ketoacidotic episodes might play a role in the development of diabetic nephropathy.
authors.forename: A
authors.initials: A
authors.lastname: Körner
authors.forename: A
authors.initials: A
authors.lastname: Szabó
authors.forename: M
authors.initials: M
authors.lastname: Miltényi
mesh_terms: D000293:Adolescent; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology / Q000652:urine; D016883:Diabetic Ketoacidosis / Q000503:physiopathology / Q000652:urine*; D006801:Humans; D007328:Insulin / Q000652:urine*; D007684:Kidney Tubules / Q000503:physiopathology
chemical_list: D007328:Insulin