title: A novel translocation, t(9;17)(q34;q23), in aggressive childhood lymphoblastic lymphoma.
abstract: In a chromosome study of childhood lymphoblastic lymphoma, we found a novel translocation, t(9;17)(q34;q23), in three patients. They presented with mediastinal mass and no bone marrow involvement. Despite intensive chemotherapy, one patient had no response, the other two relapsed after a brief remission, and all progressed to death. The 9;17 translocation may have a clinical implication for lymphoblastic lymphoma patients in predicting a poor prognosis. Since, in addition to our cases, involvement of the 9q34 breakpoint, together with 2q33, 14q11, or 7q34, has been reported in the literature in four lymphoblastic lymphoma patients, a gene located in 9q34 and referred to as tcl-3 may participate in the genesis of the T cell malignancies carrying these translocations. Furthermore, as is the case in other lymphomas, the reciprocal breakpoint, 17q23, might be the site of a yet unidentified T cell function gene.
authors.affiliation: Department of Laboratory Medicine, Saitama Cancer Center, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kaneko
authors.forename: G
authors.initials: G
authors.lastname: Frizzera
authors.forename: N
authors.initials: N
authors.lastname: Maseki
authors.forename: M
authors.initials: M
authors.lastname: Sakurai
authors.forename: Y
authors.initials: Y
authors.lastname: Komada
authors.forename: M
authors.initials: M
authors.lastname: Sakurai
authors.forename: Y
authors.initials: Y
authors.lastname: Hiyoshi
authors.forename: H
authors.initials: H
authors.lastname: Nakadate
authors.forename: T
authors.initials: T
authors.lastname: Takeda
mesh_terms: D000293:Adolescent; D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D002871:Chromosome Banding; D002886:Chromosomes, Human, Pair 17; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000145:classification / Q000235:genetics* / Q000473:pathology; D008297:Male; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D014178:Translocation, Genetic
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte