Berberine sulfate inhibits tumor-promoting activity of teleocidin in two-stage carcinogenesis on mouse skin.
Berberine sulfate, an isoquinoline alkaloid isolated from Hydrastis canadensis L., inhibited the effects of the tumor promoters 12-O-tetradecanoylphorbol-13-acetate and teleocidin, such as increased 32Pi-incorporation into phospholipids of cell membrane and hexose transport. Berberine sulfate also markedly suppressed the promoting effect of teleocidin on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene.
Nishino
H
H
Kitagawa
K
K
Fujiki
H
H
Iwashima
A
A
D019325:3-O-Methylglucose; D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001599:Berberine / Q000494:pharmacology*; D001600:Berberine Alkaloids / Q000494:pharmacology*; D001692:Biological Transport; D002273:Carcinogens / Q000037:antagonists & inhibitors*; D002478:Cells, Cultured; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006367:HeLa Cells / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D008235:Lyngbya Toxins / Q000037:antagonists & inhibitors*; D008757:Methylglucosides / Q000037:antagonists & inhibitors / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010710:Phosphates / Q000037:antagonists & inhibitors; D010743:Phospholipids / Q000378:metabolism; D011868:Radioisotopes; D012867:Skin / Q000187:drug effects; D012878:Skin Neoplasms / Q000139:chemically induced; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors; D013997:Time Factors
D001600:Berberine Alkaloids; D002273:Carcinogens; D008235:Lyngbya Toxins; D008757:Methylglucosides; D010710:Phosphates; D010743:Phospholipids; D011868:Radioisotopes; D001599:Berberine; D019325:3-O-Methylglucose; C022176:teleocidins; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate