Pathogenesis of cardiovascular disorders in streptozotocin-induced diabetes in rat. I. Cardiovascular, renal and morphologic changes in different stages of diabetes.
Some cardiovascular (heart rate and mean arterial pressure), and renal (glomerular filtration rate-GFR; renal plasma flow-RPF; filtration fraction-FF; blood urea nitrogen-BUN and albuminuria) parameters, coupled with morphologic examination, was undertaken in early (2 months) and late (6 months) stage of streptozotocin-induced diabetes mellitus in rats. The results showed a temporally (early) bradycardia and gradually increase of blood pressure with morphologic changes typical for diabetic cardiopathy. The increased GFR (by 92%), associated with significantly decreased RPF (by 37%), increased FF (by 133%), increased kidney weight/body weight ratio (by 88%), increased BUN (by 52%) and distinct albuminuria (13.53 +/- 2.08 mg/24 h/100 g b. w.), together with typical morphologic changes, suggested the development of diabetic nephropathy which was progressive with the duration of the disease.
Somova
L
L
Institute of Endocrinology and Gerontology, Medical Academy, Sofia.
Dashev
G
G
Doncheva
M
M
Vassileva
M
M
D000818:Animals; D009202:Cardiomyopathies / Q000209:etiology / Q000473:pathology*; D003921:Diabetes Mellitus, Experimental / Q000473:pathology* / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000473:pathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006439:Hemodynamics; D007515:Islets of Langerhans / Q000473:pathology; D007668:Kidney / Q000473:pathology*; D008099:Liver / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D009206:Myocardium / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation