title: Interactions of non-steroidal anti-inflammatory drugs.
abstract: As NSAIDs are commonly used in patients receiving concomitant drug therapy, there is a risk of clinically significant drug interactions. Important interactions with NSAIDs involve one or both of two major mechanisms: pharmacokinetic (e.g. lithium, phenytoin and barbiturates) and pharmacodynamic (e.g. antihypertensive agents, diuretics). Prescription of a NSAID should be preceded by a careful evaluation of any coexisting pathology (such as renal dysfunction or hypertension) or concurrent drug therapy (such as anticonvulsant or anticoagulant agents) which may predispose a patient to the development of an interaction with potentially severe effects.
authors.forename: A L
authors.initials: AL
authors.lastname: Tonkin
authors.forename: L M
authors.initials: LM
authors.lastname: Wing
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000494:pharmacology; D004344:Drug Incompatibility; D004347:Drug Interactions; D006801:Humans
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal