title: Fluoride-induced cystic changes in the enamel organ of the rat molar.
abstract: Many substances have been found to cause enamel disturbances in toxic doses, and it has been postulated that these disturbances are linked to the formation of sub-ameloblastic cysts. In the present investigation, fluoride-induced sub-ameloblastic cysts in developing rat molars were related to fluoride dose, age of the animals, and the plasma fluoride level. The sub-ameloblastic cysts, which developed predominantly towards the end of the secretory stage of amelogenesis, appeared shortly after fluoride administration and regressed within 3 days. Hypoplasias and internal defects were found in the enamel under the disturbed ameloblast layer. The highest plasma fluoride levels were found in the youngest animals 24 h after injection. The frequency and size of the sub-ameloblastic cysts were clearly related to the fluoride-dose and age of the animal and, subsequently, to the plasma fluoride level.
authors.forename: A L
authors.initials: AL
authors.lastname: Nordlund
authors.forename: J L
authors.initials: JL
authors.lastname: Ekstrand
authors.forename: L
authors.initials: L
authors.lastname: Hammarström
mesh_terms: D000565:Ameloblasts / Q000187:drug effects; D000818:Animals; D003743:Dental Enamel / Q000187:drug effects / Q000473:pathology; D003744:Dental Enamel Hypoplasia / Q000139:chemically induced / Q000473:pathology; D004658:Enamel Organ / Q000187:drug effects* / Q000473:pathology; D005260:Female; D008297:Male; D008963:Molar / Q000187:drug effects* / Q000473:pathology; D009807:Odontogenic Cysts / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000097:blood / Q000494:pharmacology* / Q000633:toxicity; D014083:Tooth Germ / Q000187:drug effects*
chemical_list: D012969:Sodium Fluoride