Maximal effective dose of cerulein in the secretin-cerulein test.
In order to determine whether the doses of cerulein generally used in the secretin-cerulein test are supramaximal, the pancreatic secretion of enzymes and bicarbonate in response to intravenous infusion of cerulein plus secretin was studied in 6 subjects on two separate days at the respective doses of 50 ng/kg/h and 0.5 CU/kg/h on one day, and 100 ng/kg/h and 1 CU/kg/h on the other. In all subjects studied, the infusion of cerulein at the dose of 100 ng/kg/h caused a pancreatic enzyme response significantly higher than that produced by 50 ng/kg/h, demonstrating that the doses of cerulein generally used in clinical practice to explore the exocrine pancreatic function are not supramaximal.
Gullo
L
L
Unit for the Study of Pancreatic Disease, University of Bologna, St. Orsola Hospital, Italy.
D000328:Adult; D001639:Bicarbonates / Q000378:metabolism; D002108:Ceruletide; D002908:Chronic Disease; D002918:Chymotrypsin / Q000378:metabolism; D002986:Clinical Trials as Topic; D010188:Exocrine Pancreatic Insufficiency / Q000175:diagnosis*; D006801:Humans; D007262:Infusions, Intravenous; D008049:Lipase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010186:Pancreatic Function Tests; D010195:Pancreatitis / Q000175:diagnosis*; D011897:Random Allocation
D001639:Bicarbonates; D002108:Ceruletide; D008049:Lipase; D002918:Chymotrypsin