title: Comparison of 5-aminosalicylic acid (3 g) and prednisolone phosphate sodium enemas (30 mg) in the treatment of distal ulcerative colitis. A prospective, randomized, double-blind trial.
abstract: Twenty-nine patients with attacks of distal ulcerative colitis were treated randomly with 3 g 5-aminosalicylic acid (5-ASA) or 30 mg of prednisolone phosphate sodium (PP) enemas (40 ml). Endoscopic, clinical, and histologic improvement were comparable in the two treatment groups. Our study showed that topical treatment with 5-ASA is as efficacious as PP in improving distal ulcerative colitis.
authors.affiliation: Division of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: C J
authors.initials: CJ
authors.lastname: Mulder
authors.forename: G N
authors.initials: GN
authors.lastname: Tytgat
authors.forename: E H
authors.initials: EH
authors.lastname: Wiltink
authors.forename: H J
authors.initials: HJ
authors.lastname: Houthoff
mesh_terms: D000328:Adult; D000368:Aged; D000636:Aminosalicylic Acids / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000473:pathology; D004311:Double-Blind Method; D004733:Enema; D005260:Female; D006801:Humans; D008297:Male; D019804:Mesalamine; D008875:Middle Aged; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011446:Prospective Studies; D011897:Random Allocation
chemical_list: D000636:Aminosalicylic Acids; D019804:Mesalamine; C009022:prednisolone phosphate; D011239:Prednisolone