title: [Two cases of Kallmann's syndrome].
abstract: Herein we report two cases of hypogonadism with anosmia or hyposmia (Kallmann's syndrome), a 23-year-old single man (case 1) and a 34-year-old single man. (case 2). Micropenis and small testes were seen in both cases. Central anosima and central hyposmia were found in cases 1 and 2, respectively. Their karyotypes were normal (46, XY). The plasma levels of LH and FSH were low and the reaction to LH-RH test was poor in both cases. After repetitious LH-RH administrations, a good response of plasma LH was recognized in both cases except for a poor response of plasma FSH in case 1, while plasma testosterone remained low in both cases. Their testicular biopsies revealed immature testes without any developed Sertoli and Leydig cells.
authors.forename: F
authors.initials: F
authors.lastname: Kondo
authors.forename: H
authors.initials: H
authors.lastname: Fujii
authors.forename: K
authors.initials: K
authors.lastname: Okamura
authors.forename: S
authors.initials: S
authors.lastname: Tokunaka
authors.forename: T
authors.initials: T
authors.lastname: Takamura
authors.forename: S
authors.initials: S
authors.lastname: Yachiku
mesh_terms: D000328:Adult; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D000857:Olfaction Disorders / Q000175:diagnosis*; D013577:Syndrome
chemical_list: D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone