title: Disposition of ceftazidime in surgical patients with intra-abdominal infection.
abstract: The disposition of ceftazidime was assessed in 11 surgical patients with suspected intra-abdominal infection. All patients had normal hepatic function, and creatinine clearances ranged from 43 to 186 ml/min. Patients received 2 g of ceftazidime intravenously every 8 h. Trough and peak concentrations in serum were measured on day 2, and trough and postdose concentrations in serum were determined on 10 samples collected during a dosage interval between days 3 and 6 of therapy. Ceftazidime peak and trough concentrations in serum at steady state determined by high-performance liquid chromatography were 257.4 +/- 122.0 (mean +/- standard deviation) and 13.1 +/- 20.6 mg/liter. The serum-concentration-versus-time profile was multiexponential. The elimination half-life, steady-state volume of distribution, and total body clearance were 2.52 +/- 1.39 h, 0.31 +/- 0.12 liter/kg, and 0.11 +/- 0.05 liter/h per kg, respectively. Total predicted body clearance significantly correlated with the measured values (r = 0.868; P = 0.001). The disposition of ceftazidime is dependent on creatinine clearance and is not significantly altered by surgery or acute infectious processes.
authors.affiliation: Drug Evaluation Unit, Hennepin County Medical Center, Minneapolis, Minnesota 55415.
authors.forename: K L
authors.initials: KL
authors.lastname: Heim-Duthoy
authors.forename: M P
authors.initials: MP
authors.lastname: Bubrick
authors.forename: D M
authors.initials: DM
authors.lastname: Cocchetto
authors.forename: G R
authors.initials: GR
authors.lastname: Matzke
mesh_terms: D000005:Abdomen; D000328:Adult; D001424:Bacterial Infections / Q000378:metabolism*; D002442:Ceftazidime / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D013514:Surgical Procedures, Operative; D013997:Time Factors
chemical_list: D002442:Ceftazidime