[Damage photosensitized by chlorine e6 in bacteria with various defects of the DNA repair system].
The goal of the work was to study the sensitivity of isogenic Escherichia coli cells differing in their ability to mediate DNA repair steps to the action of visible light sensitized by chlorine e6. Cells incapable of excision repair as well as those deficient in post-replicative recombination DNA repair were found to be much more sensitive to the combined action of visible light and chlorine e6 as compared to cells whose genes responsible for DNA repair were not damaged. The results indicate that visible light damages bacterial DNA in the presence of chlorine e6.
Zorina
T E
TE
Fomichev
A Iu
AIu
Cherenkevich
S N
SN
D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects*; D004926:Escherichia coli / Q000187:drug effects / Q000528:radiation effects*; D008027:Light / Q000009:adverse effects*; D011166:Porphyrins / Q000494:pharmacology*
D011166:Porphyrins; C006969:chlorin
Fotosensibillizirovannoe khlorinom e6 povrezhdenie bakteriĭ s razlichnymi defektami sistem reparatsii DNK.