title: Correlation between blood fibrinolytic activity, plasminogen activator inhibitor level, plasma insulin level, and relative body weight in normal and obese subjects.
abstract: This study was undertaken to obtain further information on the mechanism by which blood fibrinolytic activity, a balance between plasminogen activators and inhibitors, is lowered in obese subjects. Fasting blood samples were collected from 35 subjects, aged 15 to 45 years, with normal glucose tolerance and a Body Mass Index (BMI) varying widely between 16 and 45 (normal, 19 to 25). Euglobulin Fibrinolytic Activity (EFA) did not correlate with the level of tissue type plasminogen activator (t-PA) related antigen but exhibited a negative correlation with the level of PA inhibitor (r = -.609, P less than 0.01). EFA was negatively and PA inhibitor positively correlated with both BMI (r = -.381, P less than 0.02 and .664, P less than 0.01, respectively) and plasma insulin level (r = .410, P less than 0.02 and .521, P less than 0.01, respectively). Stepwise analysis showed that these correlations were independent. As expected, plasma insulin was correlated with BMI (r = .512, P less than 0.01) and triglyceride level (r = .38, P less than 0.02), total cholesterol with age (r = .379, P less than 0.02). Ten obese subjects were submitted to a 24-hour fast. While body weight did not change appreciably, plasma insulin decreased from 22.3 +/- 2.2 to 16.3 +/- 1.1 microU/ml, EFA increased from 3.6 +/- .8 to 4.9 +/- .67 mm, and PA inhibitor decreased from 4.52 +/- .76 to 3.44 +/- .63 IU/mL. All these differences were significant. T-PA-related antigen did not change.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.forename: P
authors.initials: P
authors.lastname: Vague
authors.forename: I
authors.initials: I
authors.lastname: Juhan-Vague
authors.forename: M F
authors.initials: MF
authors.lastname: Aillaud
authors.forename: C
authors.initials: C
authors.lastname: Badier
authors.forename: R
authors.initials: R
authors.lastname: Viard
authors.forename: M C
authors.initials: MC
authors.lastname: Alessi
authors.forename: D
authors.initials: D
authors.lastname: Collen
mesh_terms: D000293:Adolescent; D000328:Adult; D001835:Body Weight; D005260:Female; D005342:Fibrinolysis; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D015849:Plasminogen Inactivators; D012712:Serum Globulins / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000037:antagonists & inhibitors
chemical_list: D006023:Glycoproteins; D007328:Insulin; D015849:Plasminogen Inactivators; D012712:Serum Globulins; D010959:Tissue Plasminogen Activator