[The pharmacokinetics of azlocillin after single and multiple intravenous injections during the third trimester].
Examining serum level values and urinary concentrations taken from non-pregnant control persons and pregnant women suffering from urinary tract infections (UTI) during the III. trimenon, the pharmacokinetic dates after single and repeated applications of 4 g azlocillin have been evaluated. We used a computer program based on the two-compartment model. It is shown that during pregnancy complicated by UTI the elimination half-life time will be prolonged and returns after therapy nearly to normal values. The results, discussed with the dates given by literature, allow us to state that it is not necessary to change dosage and application interval of azlocillin during pregnancy.
Voigt
R
R
Klinik für Frauenheilkunde und Geburtshilfe, Bereichs Medizin, Friedrich-Schiller-Universität Jena.
Weidt
I
I
Schröder
S
S
Brandstädt
A
A
Peiker
G
G
D000328:Adult; D001390:Azlocillin / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000378:metabolism*; D011263:Pregnancy Trimester, Third; D014552:Urinary Tract Infections / Q000378:metabolism*
D001390:Azlocillin
Zur Pharmakokinetik von Azlocillin nach einfacher und wiederholter intravenöser Applikation in der Spätschwangerschaft.