Genetic aspects of tumour metastasis.
The application of techniques for the transfer of genetic material between cells when used with recombinant DNA technologies and gene cloning procedures hold exciting possibilities for the genetic analysis of the metastatic behaviour of tumour cells. So far these genetic studies have produced confusing results, but some of the problems have been defined more clearly. For a more complete understanding of the metastatic phenotype a more critical analysis of the models used to mimic the process and a greater appreciation of the deficiencies in the techniques applied to study it are necessary.
Pickford
I
I
Imperial Cancer Research Fund, Lincoln's Inn Fields, London.
Franks
L M
LM
D000818:Animals; D004195:Disease Models, Animal / Q000235:genetics / Q000473:pathology; D006801:Humans; D009362:Neoplasm Metastasis / Q000235:genetics*; D010641:Phenotype