[Estradiol and progesterone receptors in DMBA-induced mammary neoplasms in rats under cyclic hormonal exposures].
Hormones in physiological doses and under cyclic regime were injected to rats with DMBA-induced mammary tumours. It is demonstrated that 17-alpha-hydroxyprogesterone capronate (HPC) alone administered once every 6 days reduces estradiol receptor (ER) and progesterone receptor (PR) levels and the frequency of R+ tumours. Under the influence of a successive use of HPC and testosterone (TS) the level of PR and the frequency of PR+ tumours were reduced. A high level of ER and PR and a high frequency of R+ tumours were observed after a successive administration of insulin, prednisolone, HPC and TS. All the variants of hormonal influences resulted in an increased life duration of animals, a reduced growth rate, and an increased degree of mammary tumour differentiation.
Kartavova
N S
NS
Gutnik
N S
NS
Burlaka
D P
DP
Dasiukevich
O I
OI
D019326:17-alpha-Hydroxyprogesterone; D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D003600:Cytosol / Q000032:analysis / Q000187:drug effects; D005260:Female; D006908:Hydroxyprogesterones / Q000494:pharmacology*; D008325:Mammary Neoplasms, Experimental / Q000032:analysis / Q000139:chemically induced* / Q000401:mortality; D051381:Rats; D011959:Receptors, Estradiol / Q000032:analysis / Q000187:drug effects*; D011960:Receptors, Estrogen / Q000187:drug effects*; D011980:Receptors, Progesterone / Q000032:analysis / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology*; D013997:Time Factors
D006908:Hydroxyprogesterones; D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D013739:Testosterone; D015127:9,10-Dimethyl-1,2-benzanthracene; D019326:17-alpha-Hydroxyprogesterone
Retseptory éstradiola i progesterona v indutsirovannykh DMBA opukholiakh molochnoĭ zhelezy u krys pri tsiklicheskikh gormonal'nykh vozdeĭstviiakh.