title: Molecular aspects of reovirus-host cell interaction.
abstract: Reovirus biology is defined, in the main, by the sigma 1 cell attachment protein located in the virion outer capsid. Interaction of the sigma 1 protein with serotype-specific receptor molecules located on the surface of target cells determines the tropism and virulence of the virus and mediates viral inhibition of target cell growth.
authors.affiliation: Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19104.
authors.forename: J A
authors.initials: JA
authors.lastname: Cohen
authors.forename: W V
authors.initials: WV
authors.lastname: Williams
authors.forename: M I
authors.initials: MI
authors.lastname: Greene
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D036022:Capsid Proteins; D002448:Cell Adhesion; D006790:Host-Parasite Interactions; D006801:Humans; D012089:Mammalian orthoreovirus 3 / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D011991:Receptors, Virus / Q000235:genetics / Q000502:physiology; D012087:Reoviridae / Q000502:physiology*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D036022:Capsid Proteins; D011991:Receptors, Virus; D014764:Viral Proteins; C046176:reovirus type 3 receptor; C031728:sigma 1 protein, reovirus