A double blind trial of nitroglycerin vasodilator ointment in patients undergoing cytotoxic chemotherapy.
A randomized double blind controlled trial has shown that topical, nitroglycerin vasodilator cream applied to the intended injection site in patients undergoing cytotoxic chemotherapy for various malignancies, produced detectable vasodilation and a decrease in minor aids to venepuncture compared to placebo. It did not decrease the number of attempts at cannulation needed nor the overall cannulation failure rate and cannot be recommended for general use in cytotoxic chemotherapy clinics.
Manifold
I H
IH
Cole
R
R
MacKintosh
M
M
Smith
W
W
Champion
A E
AE
Hancock
B W
BW
D000287:Administration, Topical; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D005996:Nitroglycerin / Q000008:administration & dosage / Q000627:therapeutic use*; D009824:Ointments; D011292:Premedication; D011897:Random Allocation; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
D009824:Ointments; D014665:Vasodilator Agents; D005996:Nitroglycerin