[Placental passage of cefodizime].
The aim of this study was to evaluate the placental transfer of cefodizime (HR 221) in 28 women undergoing a cesarean section. After a single injection of 1 g cefodizime i.m., maternal blood, amniotic fluid and foetal cord blood samples were collected after 0.5 to 12 hours. The antibiotic assay was carried out by a microbiological procedure. The results showed a significant placental transfer of cefodizime with an early peak of 5.8 micrograms/ml at the 2nd hour in the cord blood and a progressive diffusion of the drug in the amniotic fluid until a maximal value of 9.9 micrograms/ml 11.5 hours after injection.
Berthelot
G
G
Service de Microbiologie, CHU Xavier-Bichat, Paris.
Bornet
M
M
Bergogne-Bérézin
E
E
Ravina
J H
JH
D000653:Amniotic Fluid / Q000378:metabolism; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
D002439:Cefotaxime; C033356:cefodizime
Etude du passage transplacentaire du céfodizime.