title: Anti-idiotypes and transfusions.
abstract: There is growing evidence for the existence of an idiotypic network in the mammalian response to alloantigens, in particular to MHC antigens. The direct evidence for induction of Ab-2 to particular donor HLA-specificities by DST is strong; in addition, there is recent evidence for Ab-2 to Ab-1 specific for constant regions of HLA-ABC antigens in the sera of multiply-transfused patients. On the other hand, evidence for induction of anti-TCR antibodies by DST is based primarily on functional specificity rather than biochemical evidence; the evidence available suggests that MLC BF induced by DST may be directed against V beta family or public idiotypes on recipient T cells, since the amount of inhibition obtained is weak and no evidence of "clonotypic" antibodies has been found in studies of T cell lines or lymphoblasts. Better molecular probes, including human monoclonal antibodies, T cell clones, and purified TCR are needed to screen for specific anti-idiotypes in transfused patients.
authors.affiliation: Department of Surgery, University of Wisconsin Clinical Science Center, Madison 53792.
authors.forename: W J
authors.initials: WJ
authors.lastname: Burlingham
authors.forename: H W
authors.initials: HW
authors.lastname: Sollinger
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis*; D001803:Blood Transfusion; D015395:Histocompatibility Antigens Class I / Q000008:administration & dosage / Q000276:immunology; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D015395:Histocompatibility Antigens Class I; D007130:Immunoglobulin Idiotypes