Analysis of interleukin-2 activity in patients with Behçet's disease. Ability of T cells to produce and respond to interleukin-2.
We examined interleukin-2 (IL-2) activity in patients with Behçet's disease. T cells from all patients with Behçet's disease were able to produce normal levels of IL-2 in response to phytohemagglutinin; however, responsiveness to IL-2 was impaired in their concanavalin A-activated lymphoblasts. This defect was due to decreased numbers of cells bearing IL-2 receptors in patients with early active disease; in patients with chronic active or with inactive disease, there was a decrease in density of IL-2 receptors on T cells bearing these receptors. Unresponsiveness of T cells to IL-2 may thus contribute to immunologic aberrations in Behçet's disease.
Sakane
T
T
Suzuki
N
N
Ueda
Y
Y
Takada
S
S
Murakawa
Y
Y
Hoshino
T
T
Niwa
Y
Y
Tsunematsu
T
T
D000328:Adult; D001528:Behcet Syndrome / Q000276:immunology*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D011971:Receptors, Immunologic / Q000032:analysis; D015375:Receptors, Interleukin-2; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology* / Q000648:ultrastructure
D007376:Interleukin-2; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2