Cardiac allotransplantation across major blood group barriers in the baboon.
In heterotopic heart transplantation experiments in Chacma baboons, some of the animals were significantly immunosuppressed with cyclosporine, resulting in prolonged cardiac allograft survival. ABO blood group incompatibility between recipient and donor did not significantly influence mean allograft survival, but early hyperacute (vascular) or acute (cellular) rejection occurred only when ABO incompatibility was present.
Cooper
D K
DK
Department of Cardiothoracic Surgery, University of Cape Town Medical School Republic of South Africa.
Lexer
G
G
Rose
A G
AG
Keraan
M
M
Rees
J
J
Du Toit
E
E
Oriol
R
R
D000017:ABO Blood-Group System; D000818:Animals; D001787:Blood Group Incompatibility; D003165:Complement System Proteins / Q000032:analysis; D003524:Cyclosporins / Q000627:therapeutic use; D005455:Fluorescent Antibody Technique; D006084:Graft Rejection; D006085:Graft Survival; D016027:Heart Transplantation; D007136:Immunoglobulins / Q000032:analysis; D007165:Immunosuppression Therapy / Q000662:veterinary; D009206:Myocardium / Q000473:pathology; D010215:Papio / Q000097:blood* / Q000235:genetics / Q000276:immunology; D014184:Transplantation, Homologous
D000017:ABO Blood-Group System; D003524:Cyclosporins; D007136:Immunoglobulins; D003165:Complement System Proteins