title: [The stimulating action of lipopolysaccharide and muramyl dipeptide on the activation of mononuclear cells in human peripheral blood by recombinant interleukin-2 in vitro].
abstract: Muramyl dipeptide (MDP) and lipopolysaccharide (LPS) were effective in augmentation of killer cells generation from human peripheral blood mononuclear cells (PBMC) in response to recombinant human interleukin-2 (IL-2). Pretreatment of PBMC with combination of LPS and MDP resulted in most significant their proliferation stimulated by IL-2. Thus our results show the enhancement of PBMC sensitivity to IL-2 by action of LPS, MDP and most of all by their combination in vitro.
authors.forename: A L
authors.initials: AL
authors.lastname: Rakhmilevich
authors.forename: M A
authors.initials: MA
authors.lastname: Pelevina
authors.forename: N G
authors.initials: NG
authors.lastname: Artsimovich
authors.forename: B B
authors.initials: BB
authors.lastname: Fuks
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004926:Escherichia coli; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D007376:Interleukin-2; D008070:Lipopolysaccharides; D011994:Recombinant Proteins; D000119:Acetylmuramyl-Alanyl-Isoglutamine
vernacular_title: Stimuliruiushchee deĭstvie lipopolisakharida i muramildipeptida na aktivatsiiu mononuklearov perifericheskoĭ krovi cheloveka rekombinantnym interleĭkinom-2 in vitro.