Comparison of the effect of cisapride and metoclopramide on morphine-induced delay in gastric emptying.
1. The effects of metoclopramide or cisapride on morphine-induced delay in gastric emptying in patients before surgery were compared. 2. Forty patients were allocated randomly to receive one of four premedications i.m.: placebo only, morphine 10 mg alone, morphine 10 mg with metoclopramide 10 mg and morphine 10 mg with cisapride 10 mg. Gastric emptying after each premedication was assessed indirectly from the rate of absorption of oral paracetamol. 3. Cisapride 10 mg reversed the delay in gastric emptying due to morphine. Its effects were significantly greater than those of metoclopramide 10 mg.
Rowbotham
D J
DJ
Department of Anaesthesia, Sheffield University Medical School.
Bamber
P A
PA
Nimmo
W S
WS
D000082:Acetaminophen / Q000493:pharmacokinetics; D000293:Adolescent; D000328:Adult; D020117:Cisapride; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D008875:Middle Aged; D009020:Morphine / Q000009:adverse effects* / Q000097:blood; D010880:Piperidines / Q000494:pharmacology*; D011292:Premedication; D011897:Random Allocation; D013997:Time Factors
D010880:Piperidines; D000082:Acetaminophen; D009020:Morphine; D008787:Metoclopramide; D020117:Cisapride