Evidence for a predominant renal secretion and clearance of inactive plasma renin, studied by in vivo inhibition of protein synthesis, and inhibition of renal tubular protein reabsorption.
Inactive plasma renin is mainly secreted and eliminated by the kidneys in the mouse. The half-life of inactive plasma renin is 6 hours or less. The kidneys remove inactive renin from the circulation by glomerular ultrafiltration.
Nielsen
A H
AH
Institute of Biochemistry, Royal Dental College, Copenhagen N, Denmark.
Hermann
K L
KL
Mazanti
I
I
Poulsen
K
K
D000042:Absorption; D000818:Animals; D004792:Enzyme Precursors / Q000097:blood* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism*; D051379:Mice; D012083:Renin / Q000097:blood* / Q000378:metabolism
D004792:Enzyme Precursors; D012083:Renin