Translocation (8;16)(p11;p13) in patients with acute monocytic leukemias. An evolving syndrome?
The case of a patient with a t(8;16)(p11;p13) chromosomal abnormality and acute myelomonocytic leukemia is described. Review of cases with this translocation showed that 11 of 13 patients had acute monocytic or myelomonocytic leukemia with a high frequency of extramedullary disease and phagocytosis of normal blood cells by the malignant cells. While these patients are not clinically distinct from others with acute monocytic leukemia, the characteristic features of this subset of patients will certainly evolve.
Powell
B L
BL
Department of Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
McNay
J W
JW
Brown
S
S
Cooper
M R
MR
Pettenati
M J
MJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002885:Chromosomes, Human, Pair 16; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D014178:Translocation, Genetic