Rates of micronuclei induction in different mouse strains.
It has previously been shown that the inbred mouse strain MS/Ae was more sensitive in the micronucleus test to several mutagenic agents than outbred mice. To elucidate the possible influence of inbreeding, several inbred strains including MS/Ae, AKR, BALB/c, C57 BR were compared to the two OF1 and NMRI outbred strains. The 3 mutagenic agents MNNG, MMC and MMS all induced a significantly higher number of micronuclei in the MS/Ae strain than in any of the other mouse strains. AKR was especially resistant to the alkylating agents MMS and MNNG. Hence, except for the MS/Ae mouse strain, no inbred strain showed a systematically higher sensitivity than the outbred strains for all of the 3 mutagenic agents used.
Aeschbacher
H U
HU
D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure*; D004305:Dose-Response Relationship, Drug; D008741:Methyl Methanesulfonate; D008769:Methylnitronitrosoguanidine; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D016685:Mitomycin; D008937:Mitomycins; D009152:Mutagenicity Tests / Q000379:methods*; D013045:Species Specificity
D008937:Mitomycins; D008769:Methylnitronitrosoguanidine; D016685:Mitomycin; D008741:Methyl Methanesulfonate