Differentiation of Burkitt lymphoma cells by hexamethylenbisacetamide.
Hexamethylenbisacetamide (HMBA) can induce the Burkitt lymphoma Raji cells to enter the differentiation process as evidenced by the decrease of HLA-DR antigens. This event is preceded by a decrease of c-myc expression and of the phosphorylation of cellular proteins, due to either a decrease of tyrosine protein kinase activity or an increase of tyrosine phosphatase activity. These three events form a sequence and are part of the genetic program for differentiation and growth though they may not be causally related.
Semmel
M
M
U.A. 1158 C.N.R.S., Institut Gustave Roussy, Villejuif, France.
Hanania
N
N
Huet
S
S
Pavloff
N
N
Gay
F
F
Biquard
J M
JM
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D002051:Burkitt Lymphoma; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D006684:HLA-DR Antigens / Q000032:analysis; D015151:Immunoblotting; D009693:Nucleic Acid Hybridization; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics; D016271:Proto-Oncogene Proteins c-myc; D014407:Tumor Cells, Cultured
D000081:Acetamides; D006684:HLA-DR Antigens; D011506:Proteins; D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc; D011505:Protein-Tyrosine Kinases; C014026:hexamethylene bisacetamide