[Pharmacokinetics of trometamol-fosfomycin in patients with renal insufficiency].
Trometamol fosfomycin is a new form of fosfomycin used orally. We have studied pharmacokinetics of this antibiotic in 23 uraemic patients with various degrees of renal insufficiency. The control group was 5 young adult males with a creatinine clearance of 127 +/- 20 ml/mn. All subjects received a single oral dose of 25 mg/kg trometamol fosfomycin. Serum and urine concentrations of fosfomycin were assayed by a microbiological method. Cmax, tmax, AUC were significantly higher in uraemic patients than in normal subjects. t 1/2 beta were prolonged in uraemic patients. Thus it is necessary to modify usual dose regimen when creatinine clearance is below 50 ml/mn.
Fillastre
J P
JP
Service de Néphrologie, UER de Rouen, Hôpital de Bois-Guillaume.
Leroy
A
A
Josse
S
S
Moulin
B
B
D000284:Administration, Oral; D000328:Adult; D003404:Creatinine / Q000378:metabolism; D005578:Fosfomycin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D008297:Male; D014511:Uremia / Q000378:metabolism*
D005578:Fosfomycin; D003404:Creatinine
Etude pharmacocinétique du trométamol-fosfomycine chez les malades insuffisants rénaux.