Area postrema and alcohol: effects of area postrema lesions on ethanol self-administration, pharmacokinetics, and ethanol-induced conditioned taste aversion.
An investigation was carried out to test the hypothesis that the area postrema (AP) may detect ethanol as a blood-borne toxin and thereby mediate aversive postingestinal effects of the drug. These aversive effects in turn may impose an upper limit on the amount of drug that can be consumed. In Experiment 1 rats had continuous access to water and a 4% ethanol solution. Animals with AP lesions drank more ethanol than sham-operated controls. No differences in drug disposition or metabolism were found when these rats were injected with ethanol and blood ethanol levels were measured. If the AP lesions resulted in increased ethanol drinking because of a reduction in the aversive effects of the drug, then the lesions might also be expected to attenuate a conditioned taste aversion induced by ethanol. In Experiment 2, groups of lesioned and sham-operated rats drank a novel tasting fluid and then were given i.p. injections of ethanol (0.9, 1.2, or 1.6 g/kg) or vehicle. Similar degrees of aversion to the taste of the fluid developed in both the lesioned and the sham-control groups. Since the AP lesion did not result in the attenuation of the ethanol-induced conditioned taste aversion, it was suggested that the AP may not mediate the aversive consequences of ethanol and that the increased ethanol self-administration observed in Experiment 1 may be due to other effects of the lesion.
Stewart
R B
RB
Department of Pharmacology, University of Toronto, Ontario, Canada.
Perlanski
E
E
Grupp
L A
LA
D000428:Alcohol Drinking / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001931:Brain Mapping; D002552:Cerebral Ventricles / Q000502:physiology*; D002628:Chemoreceptor Cells / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology*; D000431:Ethanol / Q000493:pharmacokinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000502:physiology*
D000431:Ethanol