title: Human immunological response to mouse monoclonal antibodies in the treatment or diagnosis of malignant diseases.
abstract: An overview of the literature is presented concerning the formation, detection, incidence and effect of the human immunoglobulin response on immunoscintigraphy. The following conclusions are drawn. The production of human anti-mouse antibodies (HAMAs) is associated with a diminished therapeutic response; adequate prevention of HAMA production is not yet possible; high HAMA titres give rise to rapid clearance of MoAb into the liver and marked reduction of tumour uptake which results in reduced image quality on immunoscintigraphy; alteration of antibody biodistribution is likely to be related to the in vivo formation of antibody-antibody complexes which could interfere with image quality when sequential imaging is carried out.
authors.affiliation: Department of Diagnostic Radiology, University Hospital Leiden, The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: Van Kroonenburgh
authors.forename: E K
authors.initials: EK
authors.lastname: Pauwels
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000917:Antibody Formation; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology* / Q000628:therapy; D011877:Radionuclide Imaging
chemical_list: D000911:Antibodies, Monoclonal