title: A neurodiagnostic approach to schizophrenia.
abstract: This article presents the perspective that cognitive and sensorimotor abnormalities are as much a part of the pathology of schizophrenia as are the symptoms. It is hypothesized that all these features cluster together in recognizable patterns. The proximate mechanisms of the abnormalities are proposed to involve anatomical and chemical lesions in a variety of locations in the brain. The functioning of widely distributed neuronal systems is thus interrupted. An approach to the assessment and interpretation of neurocognitive abnormalities is outlined. Distinct deficits require differential rehabilitation strategies.
authors.affiliation: Chedoke-McMaster Hospital, McMaster Division, Hamilton, Ontario.
authors.forename: J M
authors.initials: JM
authors.lastname: Cleghorn
mesh_terms: D001288:Attention; D001925:Brain Damage, Chronic / Q000175:diagnosis*; D006801:Humans; D009042:Motivation; D019965:Neurocognitive Disorders / Q000175:diagnosis*; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000175:diagnosis*