title: Evaluation of the mutagenic activity of leucinostatins, a novel class of antibiotic peptides produced by Paecilomyces marquandii, in the modul Aspergillus nidulans.
abstract: Leucinostatins A, B, C, D, E, G, H, and K were thoroughly investigated for their genotoxic activity using the modul Aspergillus nidulans as the test organism. The results of assays for gene mutation (8-azaguanine resistance and methionine suppressors), gene conversion, mitotic crossing-over and mitotic aneuploidy induction suggest that these peptide antibiotics lack significant mutagenicity and that non-genotoxic mechanism(s) underlie their cytotoxic properties.
authors.affiliation: Istituto Superiore di Sanità, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Crebelli
authors.forename: A
authors.initials: A
authors.lastname: Carere
authors.forename: G
authors.initials: G
authors.lastname: Conti
authors.forename: L
authors.initials: L
authors.lastname: Conti
authors.forename: C
authors.initials: C
authors.lastname: Rossi
authors.forename: L
authors.initials: L
authors.lastname: Tuttobello
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001233:Aspergillus nidulans / Q000187:drug effects* / Q000235:genetics; D008938:Mitosis; D003904:Mitosporic Fungi / Q000378:metabolism*; D009152:Mutagenicity Tests; D009154:Mutation; D010143:Paecilomyces / Q000378:metabolism*; D010455:Peptides / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides