In vitro effects of B cell growth and maturation factor on B-CLL lymphocytes.
In the presence of anti-mu Ab, B-CLL lymphocytes are able to respond to cytokines such as IL2, BCGF and IFN-alpha. IL2 is most frequently an active factor. According to the B-CLL lymphocytes population, IL2 alone can induce growth or maturation of B cells. IFN-gamma and IL2 are inefficient on B-CLL lymphocyte proliferation, but they can profoundly modulate the response to IL2. IFN-gamma can synergize with IL2. In contrast IL4 profoundly and constantly inhibits the response to IL2.
Karray
S
S
INSERM Unité 131, Clamart, France.
Emilie
D
D
Galanaud
P
P
D001402:B-Lymphocytes / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D001685:Biological Factors / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D016207:Cytokines; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology; D015847:Interleukin-4; D007378:Interleukins / Q000494:pharmacology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism / Q000473:pathology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D014407:Tumor Cells, Cultured
D001685:Biological Factors; D016207:Cytokines; D007376:Interleukin-2; D007378:Interleukins; D015847:Interleukin-4; D004247:DNA