[Stimulation of reparative processes in myocardial infarction: comparative evaluation of the effects of piracetam and inosine].
A study of 102 patients with primary macrofocal myocardial infarction, admitted to hospital within the first 6 hours after the onset of the disease, and experimental evidence obtained in 110 Wistar rats are reported. In a control group of myocardial infarction patients, collagen synthesis was depressed in the presence of the activation of free-radical lipid oxidation and circulatory hypoxia. Piracetam and inosine treatment was associated with the inhibition of free-radical lipid oxidation and a reduction of hypoxia, those being accompanied by increased collagenogenesis and accelerated postinfarction scar formation. Piracetam, as compared to inosine, had a more marked stimulating effect on the development of compensatory myocardial hypertrophy, thus contributing to rapid recovery of cardiac contractility and reducing manifestations of circulatory insufficiency.
Golikov
A P
AP
Karev
V A
VA
Polumiskov
V Iu
VIu
Konorev
L A
LA
Berestov
A A
AA
D000328:Adult; D000368:Aged; D000818:Animals; D002986:Clinical Trials as Topic; D003094:Collagen / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005260:Female; D005609:Free Radicals; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy / Q000209:etiology; D007288:Inosine / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism; D010889:Piracetam / Q000627:therapeutic use*; D011760:Pyrrolidinones / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
D005609:Free Radicals; D011760:Pyrrolidinones; D007288:Inosine; D003094:Collagen; D010889:Piracetam
Stimuliatsiia reparativnykh protsessov pri infarkte miokarda: sravnitel'naia otsenka vliianiia piratsetama i inozina.