Effects of the nitrosopeptide N-(N-acetyl-L-prolyl)-N-nitrosoglycine on Salmonella typhimurium TA100 in the host-mediated assay in mice.
The N-nitrosopeptide N-(N-acetyl-L-prolyl)-N-nitrosoglycine (APNG) was examined for mutagenicity in the mouse host-mediated assay using Salmonella typhimurium strain TA100. Administration of APNG orally or as a single ip injection was shown to produce an increase in revertants. This study provides the first evidence that APNG is absorbed after oral administration in mice and demonstrates that the mutagenic product of APNG is short-lived in vivo.
Blowers
S D
SD
British Industrial Biological Research Association, Carshalton, Surrey, England.
Brinkworth
M H
MH
Anderson
D
D
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D009153:Mutagens; D009602:Nitrosamines / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects
D009153:Mutagens; D009602:Nitrosamines; C045273:N-(N-acetylprolyl)-N-nitrosoglycine