Developmental study of SV40 large T antigen expression in transgenic mice with choroid plexus neoplasia.
Expression of SV40 large T antigen was correlated with the development of pathology in three lines of transgenic mice. Immunohistochemical detection of large T revealed positive cells only in subsets of choroid plexus epithelium, thymus and renal tubular epithelium, which was first observed during the first month of post-natal life. Morphologic abnormalities became apparent several weeks later. Only some of the choroid plexus cells which expressed T antigen progressed to form neoplasms, suggesting the need for one or more secondary events to effect transformation. Tumors did not develop in thymus and kidney.
Messing
A
A
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
Pinkert
C A
CA
Palmiter
R D
RD
Brinster
R L
RL
D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics* / Q000276:immunology; D001921:Brain / Q000502:physiology; D002551:Cerebral Ventricle Neoplasms / Q000235:genetics*; D002831:Choroid Plexus; D005786:Gene Expression Regulation; D007124:Immunoenzyme Techniques; D007668:Kidney / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D009374:Neoplasms, Experimental / Q000235:genetics*; D013950:Thymus Gland / Q000502:physiology
D000952:Antigens, Polyomavirus Transforming