title: Structure of the circumsporozoite gene of Plasmodium malariae.
abstract: The sequence of the gene encoding the circumsporozoite protein of Plasmodium malariae was determined. The central immunodominant region of the protein consists of 45 copies of the sequence Asn-Ala-Ala-Gly and 6 copies of the sequence Asn-Asp-Ala-Gly. The CSP of the monkey parasite Plasmodium brasilianum contains the same repetitive sequences. Further comparison of the two genes in regions outside the immunodominant domains reveals only three nucleotide differences and each results in an amino acid change. One is centered in a putative T-cell determinant bearing region, the second is in the putative liver binding site, and the third is part of a degenerate repeat at the start of the immunodominant region.
authors.affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD.
authors.forename: A A
authors.initials: AA
authors.lastname: Lal
authors.forename: V F
authors.initials: VF
authors.lastname: de la Cruz
authors.forename: G H
authors.initials: GH
authors.lastname: Campbell
authors.forename: P M
authors.initials: PM
authors.lastname: Procell
authors.forename: W E
authors.initials: WE
authors.lastname: Collins
authors.forename: T F
authors.initials: TF
authors.lastname: McCutchan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics* / Q000276:immunology; D001483:Base Sequence; D004247:DNA; D010961:Plasmodium / Q000235:genetics; D010965:Plasmodium malariae / Q000235:genetics*; D015800:Protozoan Proteins; D013045:Species Specificity
chemical_list: D000954:Antigens, Surface; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan; D004247:DNA