title: Magnetic resonance imaging of the breast: functional T1 and three-dimensional imaging.
abstract: Thirty-two patients with breast abnormalities and 10 normal volunteers were examined with magnetic resonance imaging (MRI) utilizing a 0.5-Tesla superconducting magnet imaging system. Sagittal, coronal, and transverse breast imaging with the 50-cm body coil and with a specialized 16 X 8 cm breast coil allowed the evaluation of a single breast. Soft-tissue contrast was clearly apparent using proton density-weighted, T1 weighted, calculated T1 images. In addition, the feasibility and potential clinical utility of three-dimensional color imaging was evaluated using computer-based interactive algorithms for edge detection of the breast and for abnormal structures within the breast. MR scan data were correlated with conventional xeromammography, ultrasound, clinical, data, and pathological specimens. In vivo and in vitro breast imaging was evaluated in a feasibility study. It was concluded that MR imaging is a most sensitive modality for the identification of breast lesions, especially when the adjacent normal tissue is primarily fat. There does appear to be significant overlap in soft-tissue contrast when the adjacent breast parenchymal tissue is fibrocystic in nature. The T1 parameter may be a relatively specific measure for identifying a malignant breast mass.
authors.forename: C L
authors.initials: CL
authors.lastname: Partain
authors.forename: M V
authors.initials: MV
authors.lastname: Kulkarni
authors.forename: R R
authors.initials: RR
authors.lastname: Price
authors.forename: A C
authors.initials: AC
authors.lastname: Fleischer
authors.forename: D L
authors.initials: DL
authors.lastname: Page
authors.forename: A W
authors.initials: AW
authors.lastname: Malcolm
authors.forename: A C
authors.initials: AC
authors.lastname: Winfield
authors.forename: A E
authors.initials: AE
authors.lastname: James
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000175:diagnosis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged