[Immunomodulating therapy of adjuvant disease in rats using cyclophosphamide in combination with prodigiozan--its effect on anti-infectious resistance].
The effect of immunomodulating therapy of adjuvant disease in rats with cyclophosphamide, prodigiozan and their combinations on infection resistance, weight of the lymphoid organs and leukocyte counts in peripheral blood, as well as the effect of prodigiozan on acute toxicity of cyclophosphamide in intact mice and mice exposed to the Freund's complete adjuvant (FCA) was studied. Prodigiozan did not increase acute toxicity of cyclophosphamide in the intact mice. It lowered the cyclophosphamide toxicity at the background of the FCA and decreased the levels of leukopenia induced by the immunosuppressor in the rats with adjuvant arthritis. It was shown on the models of local infectious inflammation caused by Proteus and lethal sepsis due to P. aeruginosa that the combined use of prodigiozan and cyclophosphamide resulted in correction of the infection resistance impairment induced by both the arthritis development and the immunosuppressor administration.
Sibiriak
S V
SV
Lazareva
D N
DN
Khaĭbullina
S F
SF
D000276:Adjuvants, Immunologic; D000818:Animals; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000276:immunology; D003520:Cyclophosphamide / Q000627:therapeutic use* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D007113:Immunity, Innate / Q000187:drug effects; D007928:Lethal Dose 50; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D011354:Prodigiozan / Q000627:therapeutic use*; D011512:Proteus Infections / Q000276:immunology / Q000517:prevention & control; D011513:Proteus mirabilis; D011552:Pseudomonas Infections / Q000276:immunology / Q000517:prevention & control; D051381:Rats
D000276:Adjuvants, Immunologic; D011135:Polysaccharides, Bacterial; D003520:Cyclophosphamide; D011354:Prodigiozan
Immunomoduliruiushchaia terapiia ad''iuvantnoĭ bolezni krys tsiklofosfamidom v sochetanii s prodigiozanom--vliianie na protivoinfektsionnuiu rezistentnost'.