Influence of pentoxifylline administered in vivo on the synthesis of PGI2 in human varicose veins.
The influence of pentoxifylline on the synthesis of prostacyclin (PGI2) was studied using human varicose veins removed by a stripping operation. Patients got 100 mg pentoxifylline iv. during the operation. The synthesis of PGI2 was studied according to the inhibition of the ADP-induced platelet aggregation without and with addition of substrate (100 ng prostaglandinendoperoxide H2) to the incubation fluid. There were no changes in the synthesis of PGI2 compared to control values.
Fahr
A
A
Department of Pharmacology and Toxicology, Martin Luther University Halle-Wittenberg, GDR.
Langer
R
R
Sziegoleit
W
W
Albert
H
H
Liebal
H
H
Mest
H J
HJ
D011464:Epoprostenol / Q000096:biosynthesis*; D006801:Humans; D007700:Kinetics; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D010431:Pentoxifylline / Q000494:pharmacology*; D012501:Saphenous Vein / Q000187:drug effects / Q000378:metabolism*; D013805:Theobromine / Q000031:analogs & derivatives*; D014648:Varicose Veins / Q000378:metabolism*
D011464:Epoprostenol; D013805:Theobromine; D010431:Pentoxifylline