Activation of mucociliary function in chronic rhinitis: a placebo-controlled study.
The effect of HR-6 solutions containing adenosine triphosphate (either 0.5 or 5 mg/ml) and placebo on the symptoms of chronic rhinitis was studied in 11 patients in randomized, crossover study. The nasal mucociliary activity present in these patients was measured by a radioisotopic method and was impaired in all patients, varying from 1.4 to 5.5 mm/min with a mean of 3.2 mm/min. The duration of each treatment was 10 days, with wash-out periods of 4 days. The relief of the nasal symptoms was recorded. The active drugs on average improved nasal mucociliary activity by 1.9-2.1 mm/min against placebo (1.4 mm/min). At the end of the trial six patients preferred the active drugs for relief of nasal symptoms, none placebo and five had no preferences. The results indicate the need for long-term studies of HR-6 in patients with impaired mucociliary function.
Nuutinen
J
J
Department of Otolaryngology, University of Kuopio, Finland.
Karttunen
P
P
Silvasti
M
M
D000255:Adenosine Triphosphate / Q000627:therapeutic use*; D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D002648:Child; D002908:Chronic Disease; D002925:Ciliary Motility Disorders / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects*; D012220:Rhinitis / Q000188:drug therapy*
D000255:Adenosine Triphosphate