title: Use of an IgA-depleted intravenous immunoglobulin in a patient with an anti-IgA antibody.
abstract: In this report we describe the use of an IgA-depleted preparation of intravenous gamma-globulin in a patient with hypogammaglobulinemia and an anti-IgA antibody. An IgA containing intravenous gamma-globulin had previously produced anaphylactoid reactions, immune complex formation, and complement activation. The patient has had no reactions to the IgA-depleted preparation after 18 months of treatment; immune complex formation and complement activation have not been demonstrated, and the titer of antibody to IgA has diminished.
authors.forename: C
authors.initials: C
authors.lastname: Cunningham-Rundles
authors.forename: S
authors.initials: S
authors.lastname: Wong
authors.forename: J
authors.initials: J
authors.lastname: Björkander
authors.forename: L A
authors.initials: LA
authors.lastname: Hanson
mesh_terms: D000361:Agammaglobulinemia / Q000276:immunology / Q000628:therapy*; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis / Q000096:biosynthesis*; D000936:Antigen-Antibody Complex / Q000378:metabolism; D003167:Complement Activation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D017098:IgA Deficiency; D007070:Immunoglobulin A / Q000276:immunology; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G / Q000627:therapeutic use*; D016756:Immunoglobulins, Intravenous; D008875:Middle Aged
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous