Compartmentalized regulation of macrophage arachidonic acid metabolism.
We show that downregulation of arachidonic acid (20:4) metabolism which occurs following i.p. injection of C. parvum can occur in a single, localized macrophage population, and is therefore unlikely to be mediated solely by a systemic factor.
Fels
A O
AO
Pawlowski
N A
NA
Abraham
E L
EL
Cohn
Z A
ZA
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D015232:Dinoprostone; D005260:Female; D007249:Inflammation / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D010743:Phospholipids / Q000378:metabolism; D011458:Prostaglandins E / Q000378:metabolism; D013189:SRS-A / Q000378:metabolism; D013929:Thromboxane B2 / Q000378:metabolism
D001095:Arachidonic Acids; D010743:Phospholipids; D011458:Prostaglandins E; D013189:SRS-A; D016718:Arachidonic Acid; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D015232:Dinoprostone