Clinical management of cytotoxic drug overdose.
In this article the pharmacological management of accidental drug overdose is discussed, with various treatments for overdose proposed, as supported by clinical facts and speculation. Current knowledge is outlined concerning dacarbazine, nitrosourea compounds, melphalan, procarbazine, cyclophosphamide, VP-16.213, l-asparaginase (colaspase), 6-mercaptopurine, mustine (nitrogen mustard), intravenous or intrathecal methotrexate (amethopterin), cytarabine (cytosine arabinoside), fluorouracil and bleomycin.
Thomas
L L
LL
Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands.
Mertens
M J
MJ
von dem Borne
A E
AE
van Boxtel
C J
CJ
Veenhof
C H
CH
Veies
E P
EP
D000970:Antineoplastic Agents / Q000506:poisoning*; D006801:Humans
D000970:Antineoplastic Agents