[The stimulating action of lipopolysaccharide and muramyl dipeptide on the activation of mononuclear cells in human peripheral blood by recombinant interleukin-2 in vitro].
Muramyl dipeptide (MDP) and lipopolysaccharide (LPS) were effective in augmentation of killer cells generation from human peripheral blood mononuclear cells (PBMC) in response to recombinant human interleukin-2 (IL-2). Pretreatment of PBMC with combination of LPS and MDP resulted in most significant their proliferation stimulated by IL-2. Thus our results show the enhancement of PBMC sensitivity to IL-2 by action of LPS, MDP and most of all by their combination in vitro.
Rakhmilevich
A L
AL
Pelevina
M A
MA
Artsimovich
N G
NG
Fuks
B B
BB
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004926:Escherichia coli; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D011994:Recombinant Proteins / Q000494:pharmacology
D007376:Interleukin-2; D008070:Lipopolysaccharides; D011994:Recombinant Proteins; D000119:Acetylmuramyl-Alanyl-Isoglutamine
Stimuliruiushchee deĭstvie lipopolisakharida i muramildipeptida na aktivatsiiu mononuklearov perifericheskoĭ krovi cheloveka rekombinantnym interleĭkinom-2 in vitro.