Results of genotoxicity testing of mazindol (degonan), lithium carbonicum (contemnol) and dropropizine (ditustat) in Chinese hamster V79 and human EUE cells.
We studied inhibition of DNA synthesis, alkaline elution of DNA, cytotoxicity and occurrence of induced 6-thioguanine resistant mutants in mammalian cells, treated with mazindol, lithium carbonicum, and dropropizine, respectively, in the presence and in the absence of microsomal fraction S9. Among the above-mentioned clinically used drugs only dropropizine showed neither mutagenic nor clastogenic effects. Lithium carbonicum manifested a weak and mazindol a medium genotoxic response which was in both cases reduced in the presence of microsomal fraction S9.
Slamenová
D
D
Budayová
E
E
Gábelová
A
A
Morávková
A
A
Pániková
L
L
D000818:Animals; D001564:Benzo(a)pyrene / Q000378:metabolism / Q000494:pharmacology; D001711:Biotransformation; D002460:Cell Line; D006224:Cricetinae; D004261:DNA Replication / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects*; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D008094:Lithium / Q000378:metabolism / Q000494:pharmacology*; D016651:Lithium Carbonate; D008168:Lung; D008297:Male; D008454:Mazindol / Q000378:metabolism / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D011409:Propylene Glycols / Q000378:metabolism / Q000494:pharmacology*
D007211:Indoles; D011409:Propylene Glycols; D016651:Lithium Carbonate; D001564:Benzo(a)pyrene; D008094:Lithium; D008454:Mazindol; C035916:dipropizine