title: [The physiological role and significance of prostaglandins in the reaction of the body to unfavorable environmental factors].
abstract: This review discusses the use of parameters of prostaglandin metabolism as criteria of human body resistance to adverse environmental effects. The paper presents observations indicating involvement of prostaglandins in responses to stress, hypoxia and ischemia. It is shown that the primary response to such effects as ionizing radiation, microwave radiation, noise, vibration, exercise, microgravity is usually characterized by increases in the concentration of most prostaglandins in organs and tissues. Development of extreme states and diseases leads to dysbalance of major prostaglandins. Knowledge of the changes involved may help improve diagnostic approaches and reliable use of prostaglandin-based drugs, their activators and inhibitors for therapeutic purposes.
authors.forename: T V
authors.initials: TV
authors.lastname: Petrova
authors.forename: I P
authors.initials: IP
authors.lastname: Bobrovnitskiĭ
mesh_terms: D000222:Adaptation, Physiological; D000337:Aerospace Medicine; D000818:Animals; D006706:Homeostasis; D006801:Humans; D009622:Noise; D011453:Prostaglandins / Q000502:physiology*; D011840:Radiation, Nonionizing; D051381:Rats; D014732:Vibration
chemical_list: D011453:Prostaglandins
vernacular_title: Fiziologicheskaia rol' i znachenie prostaglandinov v reaktsiiakh organizma na vozdeĭstvie neblagopriiatnykh faktorov vneshneĭ sredy.