title: The neurosurgeon and the blood-brain barrier. A survey.
abstract: A survey is given on the history of the discovery of the blood-brain barrier, of its functions and of its clinical importance. Also attempts to circumvent or disrupt the barrier with the aim of introducing therapeutic or diagnostic agents into the brain tissue have been reported. Finally the possible negative effects of lasting barrier defects in transplanted foetal tissue are mentioned.
authors.affiliation: Department of Neurosurgery, University Hospital Groningen, The Netherlands.
authors.forename: K G
authors.initials: KG
authors.lastname: Go
mesh_terms: D001812:Blood-Brain Barrier; D001927:Brain Diseases / Q000503:physiopathology / Q000601:surgery; D049673:History, 20th Century; D006801:Humans; D009493:Neurosurgery / Q000266:history