Isolation and structural analysis of murine c-fes cDNA clones.
The murine c-fes protein is encoded by an mRNA of 2.8 kb which is expressed predominantly in haemopoietic cell lines of the myeloid lineage. We have isolated over-lapping cDNA clones encompassing the entire coding region of murine c-fes. The predicted translation product of the c-fes mRNA is an 820 amino acid protein with 89% overall similarity to feline and human c-fes sequences, and 66% similarity to the chicken c-fps sequence. The murine c-fes proto-oncogene is related to other members of the protein tyrosine kinase family of oncogenes, although it is structurally distinct from both the receptor type, and the src family of tyrosine kinases. A comparison of the predicted protein sequence of murine, feline, human and chicken c-fps/fes proteins highlights several domains of possible functional significance in the molecule.
Wilks
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Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Kurban
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002415:Cats; D002460:Cell Line; D004247:DNA / Q000235:genetics / Q000302:isolation & purification*; D006412:Hematopoietic Stem Cells / Q000032:analysis; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051578:Proto-Oncogene Proteins c-fes; D012333:RNA, Messenger / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D004247:DNA; D011505:Protein-Tyrosine Kinases; C496645:FES protein, human; C496646:Fes protein, mouse; D051578:Proto-Oncogene Proteins c-fes