Colitis in calves: natural and experimental infection with a verotoxin-producing strain of Escherichia coli O111:NM.
Verotoxin-producing Escherichia coli O111:NM were isolated from two five week old Holstein calves with dysentery. On necropsy both calves had pseudomembranous ileitis, mucohemorrhagic colitis and proctitis. Large numbers of E. coli O111:NM were isolated from the colon and lesions typical of attaching-and-effacing E. coli were evident. The isolates from both calves had identical biochemical reactions and antimicrobial resistance patterns. Oral inoculation of a four day old colostrum deprived calf with 1 x 10(10) organisms of E. coli O111:NM produced a mild, focal colitis with typical attachment and effacement lesions. We conclude that the strain of E. coli O111:NM isolated from the clinical cases has the ability to produce colitis characterized by attachment and effacement of the colonic mucosa.
Schoonderwoerd
M
M
Animal Health Division, Alberta Agriculture, Edmonton.
Clarke
R C
RC
van Dreumel
A A
AA
Rawluk
S A
SA
D000818:Animals; D001427:Bacterial Toxins; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology* / Q000473:pathology; D003092:Colitis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D004926:Escherichia coli / Q000145:classification*; D004927:Escherichia coli Infections / Q000473:pathology / Q000662:veterinary*; D008297:Male; D022622:Shiga Toxin 1
D001427:Bacterial Toxins; D022622:Shiga Toxin 1