[Immunologic analysis of the antigenic properties of neuraminidase from drift-variants of influenza virus B].
The antigenic features of neuraminidases of several drift variants of influenza B virus were studied by enzyme immunoassay using antiserum to influenza B/USSR/100/83 virus neuraminidase isolated by pronase. Studies using immunosorption and competitive solid-phase enzyme immunoassay showed the presence in the antineuraminidase serum of at least two antibody subpopulations capable to inhibiting the activity of the enzyme and interacting with neuraminidase antigenic determinants: one detecting the antigenic determinant common for B/100/83 and B/Lee/40 viruses, and the other characterizing the antigenic determinant inherent in neuraminidase of B/100/83 virus and enzymes of drift variants isolated in 1970-1986 and lacking in the enzyme of B/Lee/40 virus.
Rovnova
Z I
ZI
Rogacheva
T A
TA
Platonova
A L
AL
Isaeva
E I
EI
D000914:Antibodies, Viral / Q000032:analysis; D000940:Antigenic Variation; D000956:Antigens, Viral / Q000032:analysis*; D007124:Immunoenzyme Techniques; D007163:Immunosorbent Techniques; D009981:Influenza B virus / Q000201:enzymology / Q000276:immunology* / Q000302:isolation & purification; D009439:Neuraminidase / Q000037:antagonists & inhibitors / Q000276:immunology* / Q000302:isolation & purification; D012692:Serial Passage; D014771:Virion / Q000276:immunology / Q000302:isolation & purification
D000914:Antibodies, Viral; D000956:Antigens, Viral; D009439:Neuraminidase
Immunologicheskiĭ analiz antigennykh svoĭstv neĭraminidazy dreĭf-variantov virusa grippa B.