[Effect of hypokinesia on the osteogenetic and hematopoietic functions of the bone marrow in mice. The ectopic bone model].
Using heterotrophic transplantation of syngenic bone marrow under the renal capsule, the effect of hypokinesia on osteogenic and hemopoietic cells-precursors as well as on de novo formed bone marrow was investigated. Altogether 16 experiments were performed, employing 260 recipients and 200 donors in two modifications: 1) bone marrow from animals exposed to hypokinesia for 3 days or 3 weeks (stage I or II of the general adaptation syndrome) was implanted to intact mice; 2) recipients who 5 to 7 day before exposure were implanted with bone marrow from intact donors were hypokinetic for 3 weeks. It was found that determined bone marrow precursors of osteogenic tissue as well as cells transferring hemopoietic microenvironment remained insensitive to hypokinesia. Three-week hypokinesia produced noticeable inhibition of osteogenesis and hemopoiesis. It is concluded that the stress-reaction plays the leading role in the changes that develop in hypokinetic mice.
Burkovskaia
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TE
Vorozhtsova
S V
SV
D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D016026:Bone Marrow Transplantation; D002455:Cell Division; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D007668:Kidney / Q000601:surgery*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008954:Models, Biological; D010012:Osteogenesis; D010024:Osteoporosis / Q000209:etiology; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000473:pathology*
Vliianie gipokinezii na kosteobrazovatel'nuiu i krovetvornuiu funktsiiu kostnogo mozga u mysheĭ na modeli ektopicheskoĭ kosti.