title: Cerebrospinal fluid pressure alterations in experimental communicating hydrocephalus. Response of cerebrospinal fluid pressure to increase in arterial carbon dioxide tension.
abstract: The response of cerebrospinal fluid (CFS) pressure to increased arterial carbon dioxide tension (PCO2) was evaluated in 5 control animals and 7 animals with experimentally induced communicating hydrocephalus. The CSF pressure in control dogs increased moderately in response to PCO2; in dogs with hydrocephalus, an increase in PCO2 produced a pronounced increase in CSF pressure accompanied by a simultaneous decrease in cerebral perfusion pressure. Progression of hydrocephalus can be explained by increased intracranial pressure, periventricular edema and cerebral ischemia.
authors.forename: E P
authors.initials: EP
authors.lastname: Strecker
authors.forename: G R
authors.initials: GR
authors.lastname: Novak
authors.forename: G
authors.initials: G
authors.lastname: Kauffmann
authors.forename: R
authors.initials: R
authors.lastname: Hemmer
authors.forename: A E
authors.initials: AE
authors.lastname: James
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood*; D004285:Dogs; D006849:Hydrocephalus / Q000134:cerebrospinal fluid*; D007427:Intracranial Pressure
chemical_list: D002245:Carbon Dioxide