Striatal and mesolimbic dopaminergic contribution to 3,4-dihydroxyphenylacetic acid sulfate in rat plasma.
Free and sulfated 3,4-dihydroxyphenylacetic acid (DOPAC) were measured in rat plasma after bilateral 6-hydroxydopamine lesions of striatum or mesolimbic tissue (nucleus accumbens + olfactory tubercle). Both lesions selectively reduced plasma DOPAC sulfate levels without altering free DOPAC or catecholamine levels in plasma, sympathetic ganglia or adrenal medulla. The present work confirms our previous findings and suggests that DOPAC sulfate functional state of striatal and mesolimbic dopaminergic neurons.
Boudet
C
C
Simon
H
H
Cottet-Emard
J M
JM
Dalmaz
Y
Y
Peyrin
L
L
D015102:3,4-Dihydroxyphenylacetic Acid / Q000097:blood*; D000818:Animals; D001923:Brain Chemistry; D002395:Catecholamines / Q000378:metabolism; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D006892:Hydroxydopamines / Q000494:pharmacology; D008032:Limbic System / Q000502:physiology*; D008297:Male; D009714:Nucleus Accumbens / Q000502:physiology; D016627:Oxidopamine; D010648:Phenylacetates / Q000097:blood*; D051381:Rats
D002395:Catecholamines; D006892:Hydroxydopamines; D010648:Phenylacetates; D015102:3,4-Dihydroxyphenylacetic Acid; D016627:Oxidopamine; D004298:Dopamine