title: [Effectiveness and tolerance of norfloxacin compared with trimethoprim-sulfamethoxazole in the treatment of uncomplicated urinary tract infections].
abstract: Forty patients with uncomplicated urinary tract infections were randomized to receive norfloxacin (400 mg) twice daily or trimethoprim-sulfamethoxazole (160-800 mg) twice daily for 10 days. The percentage of patients with bacteriological outcomes of eradication was significantly greater (p = 0.0310) with norfloxacin (90%) than the obtained percentage with trimethoprim-sulfamethoxazole (55%). The clinical response was, also, significantly better (p = 0.0012) in the norfloxacin group (100%) than in the trimethoprim-sulfamethoxazole group (55%). Two patients receiving trimethoprim-sulfamethoxazole experienced clinical side effects-gastrointestinal in nature but the treatment was not discontinued. In the norfloxacin group clinical side effects were not observed. No adverse hematological or biochemical changes were noted. From these results, we conclude that norfloxacin is more effective than trimethoprim-sulfamethoxazole in the therapy of uncomplicated urinary tract infections.
authors.affiliation: Servicios de Urología y Microbiología, Hospital Mare de Deu de l'Esperança, Barcelona.
authors.forename: J J
authors.initials: JJ
authors.lastname: Ballesteros
authors.forename: M
authors.initials: M
authors.lastname: Salvador
authors.forename: J
authors.initials: J
authors.lastname: Macías
authors.forename: J
authors.initials: J
authors.lastname: Honorato
authors.forename: A
authors.initials: A
authors.lastname: Rubio
authors.forename: J R
authors.initials: JR
authors.lastname: Azanza
mesh_terms: D002986:Clinical Trials as Topic; D004338:Drug Combinations / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D009643:Norfloxacin / Q000627:therapeutic use*; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole; D009643:Norfloxacin
vernacular_title: Estudio de la eficacia y tolerancia de norfloxacina VS trimetoprim-sulfametoxazol en el tratamiento de las infecciones urinarias no complicadas.