title: Gastric acid hypersecretion in short bowel syndrome in infants: association with extent of resection and enteral feeding.
abstract: To determine the frequency of gastric acid hypersecretion in infants with chronic malabsorption due to short bowel syndrome, acid secretory function was determined in 23 infants with malabsorption 2-22 months following small bowel resection and in a control group of 14 chronically ill, age- and weight-matched infants who did not undergo bowel resection. The prevalence of basal acid hypersecretion (defined as acid output 2 SD above the mean for the control group) was 17% (4 of 23). Basal gastric acid hypersecretion was associated with two factors: massive small bowel resection and initiation of enteral feeding. Basal acid hypersecretion was present on the initial study in 3 of 7 infants with less than one-third of the small bowel remaining, but in only 1 of 16 with more than one-third intact (p less than 0.05). Hypergastrinemia was present in 3 of 6 infants following massive bowel resection, but in only 1 of 15 with more than one-third intact (p less than 0.05), but hypergastrinemia was not consistently associated with hypersecretion. In each of six previously unfed infants, a trial of enteral feeding resulted in increased basal and maximal acid output. Three infants developed basal acid hypersecretion during initiation of enteral feeding. There was no evidence of pentagastrin-stimulated maximal acid hypersecretion in any of the infants.
authors.forename: P E
authors.initials: PE
authors.lastname: Hyman
authors.forename: S L
authors.initials: SL
authors.lastname: Everett
authors.forename: T
authors.initials: T
authors.lastname: Harada
mesh_terms: D004750:Enteral Nutrition; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism; D006801:Humans; D007223:Infant; D007421:Intestine, Small / Q000601:surgery; D008286:Malabsorption Syndromes / Q000503:physiopathology*; D008297:Male; D012778:Short Bowel Syndrome / Q000503:physiopathology* / Q000601:surgery; D013997:Time Factors
chemical_list: D005755:Gastrins