Influence of recipient and donor age in pediatric renal transplantation. Collaborative Transplant Study.
The influence of recipient and donor age on the outcome of first cadaver kidney transplants was analyzed in a series of 1325 pediatric recipients and in 4230 transplants from pediatric kidney donors. Graft survival improved significantly with increasing recipient age (P less than 0.0001) and donor age (P less than 0.0001). Combined analysis of recipient and donor age groups revealed an overriding effect of donor age on graft outcome. Kidneys from donors younger than 3 years old consistently yielded poor results regardless of recipient age. Kidneys from adult donors gave the best results even in young recipients 0-5 years of age. With adult donor kidneys in cyclosporin-treated patients, high 1-year graft survival rates of 86 +/- 9% (SE) in 15 0- to 5-year-old recipients, 85 +/- 3% in 137 6- to 12-year-old recipients, and 83 +/- 1% in 6027 13- to 40-year-old recipients were observed.
Opelz
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Institut für Immunologie der Universität, Heidelberg, Federal Republic of Germany.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D006085:Graft Survival; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016030:Kidney Transplantation; D013997:Time Factors; D014019:Tissue Donors; D014181:Transplantation Immunology