Reversibility of captopril-induced renal insufficiency after prolonged use in an unusual case of renovascular hypertension.
We report a case of severe hypertension with an occluded renal artery to a solitary kidney, who developed sudden deterioration of renal function following treatment with captopril. His renal function remained impaired but stable during 2 years' treatment with captopril but returned to pre-treatment levels soon after cessation of the drug. This indicates reversibility in captopril-induced renal failure even after its prolonged use and suggests that no organic damage occurs to glomerular arterioles following chronic ACE inhibition.
Salahudeen
A K
AK
Department of Nephrology, Central Hospital, Abu Dhabi, United Arab Emirates.
Pingle
A
A
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002216:Captopril / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006978:Hypertension, Renovascular / Q000139:chemically induced / Q000188:drug therapy*; D007668:Kidney / Q000098:blood supply; D007678:Kidney Glomerulus / Q000187:drug effects; D008297:Male; D012078:Renal Artery Obstruction / Q000139:chemically induced
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril