title: Beta-lactamase-producing isolates of Neisseria gonorrhoeae in Cape Town.
abstract: Isolates of Neisseria gonorrhoeae from patients attending the sexually transmitted disease clinics of the Cape Town Municipal Health Department were examined for beta-lactamase (penicillinase) production by a chromogenic cephalosporin test. Of the 208 isolates, 4 (less than 2%) produced beta-lactamase. When grown on chocolate blood agar plates 3 isolates showed no inhibition of growth around a penicillin disc; the 4th had a markedly reduced zone of inhibition. The minimum inhibitory concentrations of penicillin for these 4 strains were from 1 to 4 micrograms/ml.
authors.forename: J A
authors.initials: JA
authors.lastname: Simpson
authors.forename: S P
authors.initials: SP
authors.lastname: Oliver
mesh_terms: D006069:Gonorrhea / Q000382:microbiology*; D006801:Humans; D008297:Male; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D010403:Penicillin Resistance; D010405:Penicillinase / Q000032:analysis / Q000096:biosynthesis*; D013019:South Africa; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D010405:Penicillinase; D013752:Tetracycline