The effect of retinoids on the activity of the membrane form of galactosyltransferase, studied in an enzyme/liposome model system.
In the present study the effect of retinoids on the membrane form of galactosyltransferase was tested. A model system consisting of pure bovine milk galactosyltransferase and phosphatidylserine vesicles was used for this investigation. Retinol, retinal and retinylphosphate were able to overcome the modulating effect of phosphatidylserine, that is, activated the enzyme. Retinoic acid and retinylpalmitate were ineffective in this system.
Gmeiner
B M
BM
D000818:Animals; D002417:Cattle; D004224:Diterpenes; D005260:Female; D005700:Galactosyltransferases / Q000378:metabolism*; D007700:Kinetics; D008081:Liposomes; D008892:Milk / Q000201:enzymology; D010718:Phosphatidylserines; D012172:Retinaldehyde / Q000494:pharmacology; D012176:Retinoids / Q000494:pharmacology*; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives / Q000494:pharmacology
D004224:Diterpenes; D008081:Liposomes; D010718:Phosphatidylserines; D012176:Retinoids; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; C012532:retinol phosphate; D005700:Galactosyltransferases; D012172:Retinaldehyde