title: [Incidence of double-nucleated heart muscle fibers in hearts with dilated cardiomyopathy and secondary pressure or volume-induced hypertrophy].
abstract: Highly differentiated tissue as myocardium grows by amitosis. This direct nuclear partition is mirrored in double-nuclear muscle fibers. In this study we compared the occurrence of double-nuclear muscle fibers in normal hearts (n = 26) with the relations for primary (n = 17) and for secondary (n = 20) hypertrophy. In normal myocardium we found an average of 9.2 +/- 0.8% of double nuclei. Hearts hypertrophic due to valvular disease or systemic hypertension show higher (14.9 +/- 2.7) dilative cardiomyopathies (primary hypertrophy) and a significantly lower (5.4 +/- 0.7) number of double nuclei. Double nuclear counting is a simple method to distinguish a primary from a secondary hypertrophy in uncertain cases. The biological consequence of this difference, however, is not yet clear.
authors.affiliation: Institut für Pathologie, Universität Zürich.
authors.forename: R
authors.initials: R
authors.lastname: Schüpbach
authors.forename: J
authors.initials: J
authors.lastname: Schneider
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D001810:Blood Volume; D002311:Cardiomyopathy, Dilated / Q000473:pathology*; D002312:Cardiomyopathy, Hypertrophic / Q000473:pathology*; D002467:Cell Nucleus / Q000648:ultrastructure*; D005260:Female; D016027:Heart Transplantation; D006349:Heart Valve Diseases / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D011183:Postoperative Complications / Q000473:pathology
vernacular_title: Häufigkeit doppelkerniger Herzmuskelfasern in Herzen mit dilatativer Kardiomyopathie und sekundärer, druck-oder volumenbedingter Hypertrophie.