title: Multicenter private practice comparison of tripamide and hydrochlorothiazide in the treatment of hypertension.
abstract: One hundred fifty-nine patients with essential hypertension were randomly assigned to take 10 mg of tripamide or 50 mg of hydrochlorothiazide once a day for 12 weeks. Both drugs were equally effective in lowering both systolic and diastolic blood pressure in the supine (6/5 vs. 5/5 mm Hg) and standing (8/5 vs 7/6 mm Hg) positions. Tripamide had less effect on serum potassium (0.2 vs. 0.6 mEq/L decrease) and serum uric acid (0.7 vs. 1.2 mg/dL increase) than hydrochlorothiazide. The addition of propranolol to either drug produced a further reduction in blood pressure. The overall incidence and spectrum of adverse reactions were the same for both drugs.
authors.affiliation: Family Practice Center, Riverside Methodist Hospital, Columbus, OH 43214.
authors.forename: E T
authors.initials: ET
authors.lastname: Bope
authors.forename: R C
authors.initials: RC
authors.lastname: Adams
authors.forename: S C
authors.initials: SC
authors.lastname: Brewer
authors.forename: C B
authors.initials: CB
authors.lastname: Cairns
authors.forename: N R
authors.initials: NR
authors.lastname: Fosnaugh
authors.forename: P C
authors.initials: PC
authors.lastname: Leidheiser
authors.forename: C W
authors.initials: CW
authors.lastname: Platt
authors.forename: J S
authors.initials: JS
authors.lastname: Polsley
authors.forename: R R
authors.initials: RR
authors.lastname: Romaker
authors.forename: S D
authors.initials: SD
authors.lastname: Scarbrough
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005194:Family Practice; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D015337:Multicenter Studies as Topic; D011331:Private Practice; D011897:Random Allocation
chemical_list: D000959:Antihypertensive Agents; D007211:Indoles; D006852:Hydrochlorothiazide; C031282:tripamide