title: Transient late magnetic resonance imaging changes suggesting progression of brain stem glioma: implications for entry criteria for phase II trials.
abstract: An 8-year-old boy was treated with irradiation (66 Gy) for a brain stem glioma. Five months after the completion of radiotherapy, magnetic resonance imaging demonstrated apparent tumor progression despite the patient's neurological improvement. The child continued to improve, with subsequent radiographic evidence of tumor regression, without additional therapeutic intervention. The evaluations of response and recurrence of brain tumors as well as entry criteria for Phase II studies are discussed.
authors.affiliation: Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.
authors.forename: D C
authors.initials: DC
authors.lastname: Longee
authors.forename: H S
authors.initials: HS
authors.lastname: Friedman
authors.forename: W T
authors.initials: WT
authors.lastname: Djang
authors.forename: E
authors.initials: E
authors.lastname: Halperin
authors.forename: S C
authors.initials: SC
authors.lastname: Schold
authors.forename: W J
authors.initials: WJ
authors.lastname: Oakes
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D001933:Brain Stem; D002648:Child; D002986:Clinical Trials as Topic; D005910:Glioma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009460:Neurologic Examination; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents