title: [Mutability of LYS2 gene in diploid Saccharomyces yeasts. II. Frequency of mutants induced by 6-N-hydroxylaminopurine and propiolactone].
abstract: Chemical mutagens 6-N-hydroxylaminopurine (HAP) and propiolactone (PRO) induce Lys2 mutants with high frequency in diploid yeast Saccharomyces cerevisiae. HAP induces such mutants even in tetraploid strains. The genetic analysis of mutants was performed. It is shown that PRO induces mutants by means of "mutation-mitotic segregation" mechanism, while HAP induces mutants through novel mechanism "both allele mutation". Manifestation of such mechanism is the null fertility after meiosis of diploid mutants induced by HAP.
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Pavlov
authors.forename: V N
authors.initials: VN
authors.lastname: Noskov
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Chernov
authors.forename: D A
authors.initials: DA
authors.lastname: Gordenin
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000633:toxicity; D005800:Genes, Fungal; D007783:Lactones / Q000633:toxicity*; D009154:Mutation; D011003:Ploidies; D011420:Propiolactone / Q000633:toxicity*; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D007783:Lactones; C032610:6-N-hydroxylaminopurine; D011420:Propiolactone; D000225:Adenine
vernacular_title: Izuchenie mutabil'nosti gena LES2 u diploidov drozhzheĭ sakharomitsetov. Soobshchenie II. Vozniknovenie mutantov, indutsirovannykh 6-N-gidroksilaminopurinom i propiolaktonom.