[Apalcillin and renal function].
Apalcilline is a new semi-synthetic penicillin. More than 4,000 patients were treated with this antibiotic but an increase level of serum creatinine was noted in 18 cases. Responsibility of apalcilline in this side effect could be possible in 5 cases, doubtful in 13 cases. We decided to study renal function of normal volunteers treated with 4 gr apalcilline. Three periods were realised: a control period (80 min), a treatment period (60 min), a post-treatment period (40 min). Inulin and PAH infusion lasted during all these three periods. After the control period 2 gr apalcilline was injected as a bolus followed by a 2 gr apalcilline perfusion for one hour. Urinary volume was measured every 20 min. Creatinine, inulin, PAH clearances, sodium, potassium, calcium, magnesium urinary excretion were calculated for each period. Urinary B2-microglobulin excretion was also appreciated. Analysis of variance was done. We did not observe any variation of creatinine, inulin clearances or variation of urinary electrolytes output PAH clearance was significantly decreased during alpacilline infusion. Apalcilline seems competitive with PAH for proximal tubular secretion. Nevertheless apalcilline did not induce any more renal dysfunction.
Fillastre
J P
JP
Service de Néphrologie, UER de Médecine, Rouen.
Moulin
B
B
Josse
S
S
Frelon
J H
JH
D000328:Adult; D000667:Ampicillin / Q000009:adverse effects / Q000031:analogs & derivatives*; D003404:Creatinine / Q000097:blood; D004573:Electrolytes / Q000652:urine; D005260:Female; D006801:Humans; D007444:Inulin / Q000493:pharmacokinetics; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009287:Naphthyridines; D001613:beta 2-Microglobulin / Q000652:urine; D010130:p-Aminohippuric Acid / Q000493:pharmacokinetics
D004573:Electrolytes; D009287:Naphthyridines; D001613:beta 2-Microglobulin; C012122:apalcillin; D000667:Ampicillin; D007444:Inulin; D003404:Creatinine; D010130:p-Aminohippuric Acid
Apalcilline et fonction rénale.