title: Time trend in annual kidney graft survival.
abstract: First cadaver, unrelated kidney graft survival at one year from 50 Eurotransplant centers was analyzed and found to show marked changes in survival rates over the 20-year period from 1967 to 1986 inclusive. Full information on HLA-A, -B, and -DR matching and use of cyclosporine therapy was only available for the period 1981 to 1986. When these factors were allowed for, the number (and type) of HLA mismatches was shown to have a significant and independent effect on differences in survival rates whereas the effect of cyclosporine differed over the different years.
authors.affiliation: Eurotransplant Foundation, University Hospital, Leiden, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Thorogood
authors.forename: J C
authors.initials: JC
authors.lastname: van Houwelingen
authors.forename: J J
authors.initials: JJ
authors.lastname: van Rood
authors.forename: G G
authors.initials: GG
authors.lastname: Persijn
mesh_terms: D002102:Cadaver; D003524:Cyclosporins / Q000627:therapeutic use; D005060:Europe; D006085:Graft Survival / Q000187:drug effects; D006648:Histocompatibility; D006801:Humans; D016030:Kidney Transplantation; D013997:Time Factors
chemical_list: D003524:Cyclosporins