[Use of a protoplasting method for altering the qualitative and quantitative composition of the anthracycline complex in Streptomyces peucetius var. caesius].
Conditions for efficient regeneration in mutant strains of the doxorubicin-producing organism Str. peucetius var. caesius were developed. The effect of the protoplast regeneration on changes in the proportion of the components of the anthracycline complex produced by these strains was shown. Variants with doxorubicin productivity 2 times higher than that of the parent strain were isolated.
Krasil'nikova
O L
OL
Anisova
L N
LN
Romanova
N B
NB
Bartoshevich
Iu E
IuE
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D001431:Bacteriological Techniques; D003630:Daunorubicin / Q000031:analogs & derivatives / Q000096:biosynthesis; D004317:Doxorubicin / Q000096:biosynthesis; D009154:Mutation; D011523:Protoplasts / Q000502:physiology*; D012641:Selection, Genetic; D013302:Streptomyces / Q000378:metabolism / Q000648:ultrastructure*
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; C000847:daunorubicinol; D003630:Daunorubicin
Ispol'zovanie metoda protoplastirovaniia dlia izmeneniia kachestvennogo i kolichestvennogo sostava antratsiklinovogo kompleksa u Streptomyces peucetius var. caesius.