title: The incidence of immunosuppression-related skin disease in long-term transplant patients.
abstract: One hundred and twenty-one patients who had received a renal allograft between 4 months and 21 years previously (mean +/- SD, 71 +/- 62 months) were studied. Seventy-two patients were conventionally immunosuppressed with azathioprine and prednisolone, and 36 had been exposed to the current regime of cyclosporine, azathioprine, and prednisolone. Forty-five patients had viral warts, of whom 20 had more than 10 warts. The presence of viral warts was significantly associated with pale skin type, excess sun exposure, and with duration of allograft. Viral warts were significantly more common in those on conventional immunosuppressive therapy, but this could be solely a reflection of the difference in duration of transplant between the 2 groups. Twelve patients were found to have developed dysplastic or neoplastic skin lesions since transplantation. The incidence of dysplasia increased with increasing age and was significantly associated with pale skin type, excess sun exposure, and duration of allograft. Despite the shorter duration of treatment in those on the new treatment regime, there was no difference between the 2 groups in the proportion of patients with dysplastic skin lesions. Immunosuppression-related skin disease may be a significant problem in allograft recipients in this country, and we suspect that patients taking cyclosporine will have similar problems to those on conventional immunosuppressive drugs alone. Immunosuppressed patients should be advised to avoid sun exposure, to use sunscreens, and should be monitored carefully for the development of dysplastic lesions.
authors.affiliation: Department of Medicine, Hammersmith Hospital, London, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: McLelland
authors.forename: A
authors.initials: A
authors.lastname: Rees
authors.forename: G
authors.initials: G
authors.lastname: Williams
authors.forename: T
authors.initials: T
authors.lastname: Chu
mesh_terms: D003881:Dermatomycoses / Q000139:chemically induced; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016030:Kidney Transplantation; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced*; D012878:Skin Neoplasms / Q000139:chemically induced; D012880:Skin Pigmentation; D014860:Warts / Q000139:chemically induced*
chemical_list: D007166:Immunosuppressive Agents