Decreased gastro-intestinal responses to salbutamol and serotonin in streptozotocin-induced diabetes: improving effect of insulin in vivo and in vitro.
1. Decreased gastro-intestinal responses to salbutamol (sal) and serotonin (5-HT) in experimental diabetes have been postulated. The present study was designed to investigate whether in vivo and in vitro insulin treatments improve the decreased gastro-intestinal responses. 2. In vivo insulin treatment (166.7 micrograms/kg/day i.p.) for 6 weeks is able to improve both decreased gastro-intestinal beta-adrenergic and serotonergic responses. 3. Insulin incubation in bathing medium for 4-5 hr enhances the decreased gastro-intestinal responses to sal, but not to 5-HT. 4. The above results strongly suggest that the improving effect of insulin on the gastro-intestinal beta-adrenergic responses is direct in nature. In contrast, the improving effect on insulin on the serotonergic responses occurs via an indirect mechanism.
Yidizoğlu-Ari
N
N
Department of Pharmacology, Faculty of Pharmacy, University of Ankara, Turkey.
Altinkurt
O
O
Oztürk
Y
Y
Altan
V M
VM
Pekiner
C
C
Karasu
C
C
D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004386:Duodenum / Q000187:drug effects / Q000503:physiopathology; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects / Q000503:physiopathology
D007328:Insulin; D012701:Serotonin; D000420:Albuterol