title: Comparison of glucose, LCT, and LCT plus MCT as calorie sources for parenterally nourished septic rats.
abstract: Protein and energy metabolism were investigated in acutely septic rats. Rats were made septic by cecal puncture and ligation. For the next 24 h they were given one of five parenteral formulations differing only in the nonprotein calorie source. The five calorie sources were 1) glucose, 2) long-chain triglycerides (LCT), 3) a 27:73 mixture of medium- and long-chain triglycerides (M/LCT), 4) a 50:50 mixture of glucose plus LCT, and 5) a 50:50 mixture of glucose plus the M/LCT mixture. The formulations also contained amino acids at a calorie:ratio of 165:1. The results were that N retention was greater with the glucose plus LCT mixture than with glucose alone. With this mixture, N retention increased as calorie intake increased, whereas with glucose, N retention plateaued. In spite of the high glucose load given to the glucose-only groups, there was a significant reduction in endogenous fat in peripheral depots. Lipid loss was least with the glucose plus LCT combination. The M/LCT mixture given alone or with glucose resulted in significantly lower survival rates.
authors.forename: T P
authors.initials: TP
authors.lastname: Stein
authors.forename: R C
authors.initials: RC
authors.lastname: Fried
authors.forename: M H
authors.initials: MH
authors.lastname: Torosian
authors.forename: M J
authors.initials: MJ
authors.lastname: Leskiw
authors.forename: M D
authors.initials: MD
authors.lastname: Schluter
authors.forename: R G
authors.initials: RG
authors.lastname: Settle
authors.forename: G P
authors.initials: GP
authors.lastname: Buzby
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D002149:Energy Intake; D004734:Energy Metabolism; D005260:Female; D005526:Food, Formulated; D005947:Glucose / Q000008:administration & dosage* / Q000378:metabolism; D007239:Infections / Q000378:metabolism / Q000628:therapy*; D008099:Liver / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism; D010289:Parenteral Nutrition, Total; D051381:Rats; D014280:Triglycerides / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D000596:Amino Acids; D014280:Triglycerides; D005947:Glucose; D009584:Nitrogen