title: Normal and dystrophin-deficient muscle fibers in carriers of the gene for Duchenne muscular dystrophy.
abstract: Dystrophin is the gene product that is affected in Duchenne muscular dystrophy (DMD). Antibodies against dystrophin were used to study the protein in muscle fibers of carriers of the gene. The results showed that DMD carriers have normal and dystrophin-deficient fibers. Dystrophin immunohistochemistry may be helpful for the detection of DMD carriers.
authors.affiliation: Department of Neurology, College of Physicians & Surgeons, Columbia University, Columbia Presbyterian Medical Center, New York, New York.
authors.forename: E
authors.initials: E
authors.lastname: Bonilla
authors.forename: B
authors.initials: B
authors.lastname: Schmidt
authors.forename: C E
authors.initials: CE
authors.lastname: Samitt
authors.forename: A F
authors.initials: AF
authors.lastname: Miranda
authors.forename: A P
authors.initials: AP
authors.lastname: Hays
authors.forename: A B
authors.initials: AB
authors.lastname: de Oliveira
authors.forename: H W
authors.initials: HW
authors.lastname: Chang
authors.forename: S
authors.initials: S
authors.lastname: Servidei
authors.forename: E
authors.initials: E
authors.lastname: Ricci
authors.forename: D S
authors.initials: DS
authors.lastname: Younger
mesh_terms: D000328:Adult; D001706:Biopsy; D016189:Dystrophin; D005260:Female; D005455:Fluorescent Antibody Technique; D005629:Frozen Sections; D006580:Genetic Carrier Screening / Q000379:methods*; D006579:Heterozygote; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009124:Muscle Proteins / Q000032:analysis*; D009132:Muscles / Q000032:analysis* / Q000473:pathology; D009136:Muscular Dystrophies / Q000235:genetics* / Q000473:pathology
chemical_list: D016189:Dystrophin; D009124:Muscle Proteins