title: Analgesic activity of flupirtine maleate: a controlled double-blind study with diclofenac sodium in orthopaedics.
abstract: A controlled, parallel group study of the analgesic efficacy of flupirtine maleate, was compared against diclofenac sodium in 40 orthopaedic patients with post-operative pain. Clinically, both drugs were of equal analgesic efficacy. A mathematical model has been developed, however, to evaluate the speed, intensity and duration of the analgesic effect and provides data which significantly favour flupirtine maleate in the treatment of these patients.
authors.affiliation: II Faculty of Medicine and Surgery, University of Naples, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Mastronardi
authors.forename: M
authors.initials: M
authors.lastname: D'Onofrio
authors.forename: E
authors.initials: E
authors.lastname: Scanni
authors.forename: M
authors.initials: M
authors.lastname: Pinto
authors.forename: S
authors.initials: S
authors.lastname: Frontespezi
authors.forename: M G
authors.initials: MG
authors.lastname: Ceccarelli
authors.forename: F
authors.initials: F
authors.lastname: Bianchi
authors.forename: B
authors.initials: B
authors.lastname: Mazzarella
mesh_terms: D000328:Adult; D000631:Aminopyridines / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000700:Analgesics / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004008:Diclofenac / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009985:Orthopedics; D010149:Postoperative Pain / Q000188:drug therapy*
chemical_list: D000631:Aminopyridines; D000700:Analgesics; D004008:Diclofenac; C034161:flupirtine