Effect of the variations of female sex hormones during the menstrual cycle upon serum somatomedin and growth-promoting activity.
Serum growth-promoting activity measured upon lymphocytes, sulfation activity and radioimmunoassayable somatomedin C (Sm-C) levels were measured in sera from women during the menstrual cycle. The data showed that: estradiol, progesterone, LH or FSH added in vitro do not increase the 3H-thymidine uptake into lymphocytes; the serum thymidine activity decreases during the luteal stage of the cycle, and is negatively correlated with the progesterone levels; the sulfation factor and Sm-C levels do not have significant variations during the menstrual cycle, and the GH maximum values are attained during the luteal stage.
Guidoux
S
S
Garnier
P E
PE
Schimpff
R M
RM
D000328:Adult; D003276:Contraceptives, Oral / Q000494:pharmacology; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood* / Q000502:physiology; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D007334:Insulin-Like Growth Factor I / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008214:Lymphocytes / Q000378:metabolism*; D008597:Menstrual Cycle; D008875:Middle Aged; D011374:Progesterone / Q000097:blood; D013002:Somatomedins / Q000097:blood*; D013936:Thymidine / Q000378:metabolism
D003276:Contraceptives, Oral; D012739:Gonadal Steroid Hormones; D013002:Somatomedins; D011374:Progesterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone; D013936:Thymidine