Hematopoietic activities of interleukin 1.
IL-1 is perhaps the most pleiomorphic of the cytokines. Only recently however has it been suspected that IL-1 has effects in stimulating hematopoiesis. Its principal effect in this regard seems to be stimulation of pluripotent stem cells, causing these cells to then respond to lineage-specific growth factors. Thus, although IL-1 does not function directly as a colony stimulating factor, it synergizes with G-CSF, GM-CSF, and IL-3. Indeed, biochemical and serological evidence suggests that IL-1 accounts totally for the biological activity previously termed hemopoietin-1 which has been shown to play a central role in the regulation of hematopoiesis.
Henney
C S
CS
Immunex Corporation, Seattle, Washington 98101.
D000818:Animals; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology / Q000502:physiology*
D007375:Interleukin-1