Physiologic pharmacokinetic modeling.
Although physiologic modeling has not gained the widespread acceptance that was originally projected, it may serve as the basis for future PK/PD modeling approaches. In addition, with more effort applied to developing in vitro and animal-to-human predictions, physiologic modeling may assume a higher position in the pharmacokinetic modeling hierarchy.
Colburn
W A
WA
Pharmacokinetics/Drug Metabolism Department, Parke-Davis Pharmaceutical Research, Warner-Lambert Company, Ann Arbor, Michigan 48105.
D000818:Animals; D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics