title: BCG-modulated mammary carcinogenesis is dependent on the schedule of immunization but is not affected by dietary fat.
abstract: The present study was designed to study the effect of dietary fat intake on the modulation of dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in rats injected with the methanol extract residue of Bacillus Calmette-Guerin (MER-BCG). Rats were maintained on either a 5% or a 20% corn oil diet for the entire duration of the experiment. When MER-BCG was administered 2 and 3 weeks before DMBA, mammary tumorigenesis was suppressed in the 2 dietary groups with different levels of fat intake. This was in contrast to when MER-BCG was administered 3 and 5 weeks after DMBA; in this case the development of mammary tumors was noticeably enhanced regardless of the fat intake of the host. The magnitude of inhibition or increase by MER-BCG was similar in animals fed either fat level, although a high fat diet consistently stimulated mammary tumorigenesis in the 2 experiments. In vitro assays on T cell mitogen-induced blastogenesis and natural killer cell activity in splenocytes isolated from the untreated rats showed that dietary fat failed to elicit any differential response in these immune functions.
authors.forename: C
authors.initials: C
authors.lastname: Ip
authors.forename: G
authors.initials: G
authors.lastname: White
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage*; D004041:Dietary Fats; D005260:Female; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology
chemical_list: D001500:BCG Vaccine; D004041:Dietary Fats; D015127:9,10-Dimethyl-1,2-benzanthracene