[Influence of the inoculum effect on minimal inhibitory concentrations of 3 derivatives of 5-nitro-imidazole and 11 other antibiotics on Bacteroides fragilis].
Three nitro-imidazole derivatives and eleven other antibiotics were studied for both their antimicrobial activity and the degree to which they produced inoculum effect on twenty strains of Bacteroides fragilis group. Five inocula were studied ranging from 10(5) to 10(9) CFU/ml. Statistical analysis show the significant influence of inoculum and those of strains. Nitro-imidazole derivatives exhibited a large inoculum effect while other antibiotics exhibited only a minimal to-no-inoculum effect.
Dusart
G
G
Laboratoire de Bactériologie et Biologie cellulaire, Factulé de Pharmacie, Montpellier.
Simeon de Buochberg
M
M
Maillols
H
H
Zuccarelli
M
M
Attisso
M A
MA
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001441:Bacteroides fragilis / Q000187:drug effects*; D007769:Lactams; D008826:Microbial Sensitivity Tests / Q000379:methods*; D009593:Nitroimidazoles / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D007769:Lactams; D009593:Nitroimidazoles
Influence de l'effet inoculum sur les concentrations minimales inhibitrices de trois dérivés du 5-nitro-imidazole et onze autres antibiotiques sur Bacteroides du groupe fragilis.