Porous collagen sponge wound dressings: in vivo and in vitro studies.
Collagen-based materials can be formed into a three-dimensional sponge for use as a wound dressing and as a support for cell cultured skin components. Factors such as biocompatibility, morphological structure and addition of non-collagenous molecules to collagen are analyzed and discussed. Large pores or channels, interchannel communications and combinations of macromolecules of the connective tissue enhance wound tissue infiltration in vivo as well as cell growth in vitro into collagen sponges. The presence of such factors can be useful in patients with excised burn wounds and pressure skin ulcers.
Doillon
C J
CJ
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Pathology, Piscataway 08854-5635.
D000818:Animals; D001458:Bandages; D001684:Biological Dressings; D003094:Collagen; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D014945:Wound Healing
D003094:Collagen