Therapeutic interventions in nephropathy of IDDM.
The pathophysiology of diabetic renal disease has been greatly clarified in recent years. A better understanding of its developmental stages has led to a series of therapeutic intervention trials. I describe the natural history of untreated insulin-dependent diabetes mellitus (IDDM) and the effects of various intervention modalities. Selected trials, some of them still in progress, are summarized, including studies of therapy with insulin, antihypertensives, and low-protein diets.
Mogensen
C E
CE
Second University Clinic of Internal Medicine, Kommunehospitalet, Aarhus, Denmark.
D002986:Clinical Trials as Topic / Q000379:methods; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology / Q000628:therapy*; D003928:Diabetic Nephropathies / Q000503:physiopathology / Q000628:therapy*; D006801:Humans