Present and future applications of vaccinia virus as a vector.
The use of live recombinant vaccinia virus strains, which are capable of expressing immunoreactive epitopes from pathogenic agents, holds great promise as a means of immunoprophylaxis against a variety of human and animal diseases. This review will outline the basic methodology employed by this approach, summarize some recent technological advancements which should facilitate the construction of genetically-engineered recombinant viruses, and consider potential future applications of this avenue of research.
Hruby
D E
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Department of Microbiology, Oregon State University, Corvallis 97331-3804.
D000818:Animals; D006801:Humans; D007114:Immunization; D014612:Vaccines; D014614:Vaccines, Synthetic; D014616:Vaccinia virus / Q000235:genetics / Q000276:immunology*
D014612:Vaccines; D014614:Vaccines, Synthetic