Antiparasitic activity of nine pyrazole derivatives against Trichomonas vaginalis, Entamoeba invadens and Plasmodium berghei.
Nine nitropyrazole derivatives were prepared and tested against Trichomonas vaginalis in vitro and in vivo, Entamoeba invadens in vitro and Plasmodium berghei in vivo. Three of the compounds, 4-4-nitropyrazole, 1-methyl-4-nitropyrazole and 4,4'-dinitro-1,1'-methylenedipyrazole, have an activity similar to that of metronidazole (used as the reference compound) against T. vaginalis and E. invadens after 48 hours of incubation. All the compounds tested were inactive against P. berghei.
Escario
J A
JA
Department of Parasitology, Faculty of Pharmacy, Complutense University, Madrid, Spain.
Igea
A M
AM
Contreras
M
M
Martinez-Fernandez
A R
AR
Claramunt
R
R
Lopez
C
C
D000818:Animals; D002738:Chloroquine / Q000627:therapeutic use; D004747:Entamoeba / Q000187:drug effects*; D005260:Female; D066298:In Vitro Techniques; D008288:Malaria / Q000188:drug therapy; D008795:Metronidazole / Q000627:therapeutic use; D051379:Mice; D010962:Plasmodium berghei / Q000187:drug effects*; D011720:Pyrazoles / Q000494:pharmacology* / Q000627:therapeutic use; D014247:Trichomonas Vaginitis / Q000188:drug therapy; D014246:Trichomonas vaginalis / Q000187:drug effects*
D011720:Pyrazoles; D008795:Metronidazole; D002738:Chloroquine