[In vitro activity of beta-lactams, clindamycin and metronidazole on Clostridium difficile].
In one year and a half period 47 Clostridium difficile were isolated from stool samples. Isolates with questionable morphologic features were identified using sugars fermentation, gaz liquid chromatography (GLC). Cytotoxin assay was performed on Mac Coy cells. The comparative susceptibilities to amoxicillin-clavulanic acid (AMC), cefotetan (CTT), cefoxitin (FOX), cefotaxime (CTX), latamoxef (MOX), mezlocillin (MEZ), piperacillin (PIP), clindamycin (CLIN) and metronidazole was tested using minimal inhibition concentration (MIC) determination on Wilkins-Chalgren blood agar. CLIN, FOX, CTX, MOX were inactive, CTT is moderately inactive. All strains were susceptible to AMX, MEZ, PIP and metronidazole.
Sedallian
A
A
Laboratoire de Bactériologie, Centre Hospitalier d'Annecy.
Debrueres
J
J
Roudon
T
T
Deronzier
M
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D003013:Clostridium / Q000187:drug effects*; D003015:Clostridium Infections / Q000188:drug therapy; D006801:Humans; D066298:In Vitro Techniques; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D008795:Metronidazole; D002981:Clindamycin
Activité in vitro des bêtalactamines, de la clindamycine et du métronidazole sur Clostridium difficile.