title: On the biophysics of transmembrane signalling.
abstract: Transmembrane signalling involves a number of physical translocations, changes in proximity of membrane elements like receptor subunits, or sequestration of proteins from the membrane. The monitoring of such changes with flow cytometric energy transfer revealed a new putative subunit of the IL-2 receptor and a possible intermolecular interaction between HLA class I and class II antigens. Lateral diffusion of the components of the multi-subunit IL-2 receptor was also followed. Changes in the intracellular pH were considered as a measure of efficient signal transfer in a number of cases. An overview and critical comparison of data is presented in the paper.
authors.affiliation: Department of Biophysics, Medical University School of Debrecen, Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Trón
authors.forename: A
authors.initials: A
authors.lastname: Aszalós
authors.forename: M
authors.initials: M
authors.lastname: Balázs
authors.forename: S A
authors.initials: SA
authors.lastname: Mulhern
authors.forename: J
authors.initials: J
authors.lastname: Szöllösi
authors.forename: S
authors.initials: S
authors.lastname: Damjanovich
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D002462:Cell Membrane / Q000502:physiology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D015375:Receptors, Interleukin-2 / Q000276:immunology; D015398:Signal Transduction
chemical_list: D006680:HLA Antigens; D015375:Receptors, Interleukin-2