title: Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase.
abstract: A bovine adrenal cDNA clone encoding the entire alpha subunit of the GTP-binding regulatory protein that stimulates adenylate cyclase (Gs) was isolated and sequenced. This cDNA directed the synthesis of the larger, 52-kDa form of the polypeptide in COS cells, even though the clone appeared to encode a 46-kDa protein. Comparison of the deduced amino acid sequence of Gs alpha with the alpha subunit of another G protein, transducin, revealed striking homologies.
authors.forename: J D
authors.initials: JD
authors.lastname: Robishaw
authors.forename: D W
authors.initials: DW
authors.lastname: Russell
authors.forename: B A
authors.initials: BA
authors.lastname: Harris
authors.forename: M D
authors.initials: MD
authors.lastname: Smigel
authors.forename: A G
authors.initials: AG
authors.lastname: Gilman
mesh_terms: D000262:Adenylyl Cyclases; D000311:Adrenal Glands; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D019204:GTP-Binding Proteins / Q000235:genetics*; D046911:Macromolecular Substances; D011518:Proto-Oncogene Proteins / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
chemical_list: D046911:Macromolecular Substances; D011518:Proto-Oncogene Proteins; D004247:DNA; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases