An approach to AIDS therapy using hyperthermia and membrane modification.
Altering the biophysical characteristics of cell membranes by diet and membrane perturbing agents markedly influences thermosensitivity of cells. Likewise, manipulation of viral envelopes either by altering their lipid composition by diet or by the use of agents that perturb the lipid envelope influence infectivity of enveloped viruses and the progression of viral disease. The use of hyperthermia and envelope modification as a combined approach to treat AIDS has until now neither been suggested nor attempted. On the basis of my previous work and a review of the literature, I theorize that the combination of hyperthermia with procedures designed to alter the viral envelope will likely result in an increased viral sensitivity and be useful clinically for treatment of patients with enveloped viral diseases such as AIDS.
Yatvin
M B
MB
University of Wisconsin Medical School, Madison 53706.
D000163:Acquired Immunodeficiency Syndrome / Q000628:therapy*; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use; D006678:HIV / Q000378:metabolism; D006801:Humans; D006979:Hyperthermia, Induced; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000378:metabolism
D008563:Membrane Lipids; D002084:Butylated Hydroxytoluene