title: Comparative effects of meals high in protein, sucrose, or starch on human mineral metabolism and insulin secretion.
abstract: Protein, carbohydrates, and amino acids produce calciuria by decreasing renal calcium reabsorption. This study compared the postprandial calciuretic and serum insulin responses of 12 adults to isocaloric meals: Control, High Protein, High Sucrose, and High Starch. In 3 h 60% more Ca was excreted after High Protein than after other meals; renal Ca reabsorption was lower after High Protein than after High Sucrose at 2.5 h and after High Starch and High Sucrose at 3 h (p less than 0.01). Insulin was higher after High Starch and High Sucrose than after High Protein. Urinary phosphorus excretion was lower 1-3 h after High Protein than after other meals (p less than 0.01). High Protein increased urinary potassium and zinc. Urinary Ca correlated significantly with urinary Zn (r = 0.64) and sodium (r = 0.62), peak serum P (r = -0.29), and serum insulin increase for Control (r = 0.70) and High Protein (r = 0.68) only. Insulin inhibition of Ca reabsorption is not the sole explanation of macronutrient-induced calciuria.
authors.affiliation: Department of Nutritional Sciences, University of Connecticut, Storrs.
authors.forename: M G
authors.initials: MG
authors.lastname: Holl
authors.forename: L H
authors.initials: LH
authors.lastname: Allen
mesh_terms: D000328:Adult; D002118:Calcium / Q000097:blood; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D008903:Minerals / Q000378:metabolism*; D010758:Phosphorus / Q000097:blood; D011188:Potassium / Q000097:blood; D012727:Sex Characteristics; D012964:Sodium / Q000097:blood; D013213:Starch / Q000008:administration & dosage*; D013395:Sucrose / Q000008:administration & dosage*; D015032:Zinc / Q000097:blood
chemical_list: D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D007328:Insulin; D008903:Minerals; D010758:Phosphorus; D013395:Sucrose; D013213:Starch; D012964:Sodium; D015032:Zinc; D011188:Potassium; D002118:Calcium