Clinical pharmacokinetics of doxycycline and minocycline.
Doxycycline and minocycline are second-generation tetracyclines. They are readily absorbed, distributed throughout the organism as a function of their lipophilicity and eliminated in both the urine and the faeces. The influence of age, renal disease, malnutrition and hyperlipidaemia is reviewed, together with the main pharmacokinetic interactions.
Saivin
S
S
Unité de Pharmacocinétique Clinique, CHU Purpan, Toulouse, France.
Houin
G
G
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D004318:Doxycycline / Q000378:metabolism / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism; D008297:Male; D008911:Minocycline / Q000378:metabolism / Q000493:pharmacokinetics*; D011247:Pregnancy; D012737:Sex Factors; D013754:Tetracyclines / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D013754:Tetracyclines; D008911:Minocycline; D004318:Doxycycline