title: Can thrombolysis prevent ischemic heart failure?
abstract: In the present era of thrombolysis, congestive heart failure secondary to (sub)acute coronary artery obstruction can be reduced to a considerable extent or even avoided altogether. Evidence from several recent trials in humans, aimed at restoring perfusion of the jeopardized myocardium-and thus preserving normal ventricular function-is presented. It is clear that thrombolysis, provided it is instituted within 4 h of onset of symptoms in patients with a large area of the myocardium at risk, can prevent ischemic heart failure.
authors.affiliation: Thorax Center, University Hospital, Erasmus University, Rotterdam, The Netherlands.
authors.forename: P G
authors.initials: PG
authors.lastname: Hugenholtz
authors.forename: M L
authors.initials: ML
authors.lastname: Simoons
mesh_terms: D002986:Clinical Trials as Topic; D003328:Coronary Thrombosis / Q000188:drug therapy; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006333:Heart Failure / Q000517:prevention & control*; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy*
chemical_list: D005343:Fibrinolytic Agents