Effect of ranitidine on meal-induced gastric pepsin and acid secretion and the influence of adding ethanol to the meal.
The effect of ranitidine on meal-stimulated pepsin and acid secretion 3-4 h after administration of the drug was compared in 10 healthy volunteers. The results showed an insignificant reduction of pepsin output, whereas acid output was reduced 78.5%, demonstrating the difference in response of the chief and parietal cells to an H2-receptor antagonist. Adding ethanol to the meal did not reduce the acid-inhibiting effect of ranitidine.
Frislid
K
K
Berstad
A
A
D000328:Adult; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005502:Food; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D010434:Pepsin A / Q000378:metabolism*; D011899:Ranitidine / Q000494:pharmacology*; D013997:Time Factors
D000431:Ethanol; D011899:Ranitidine; D010434:Pepsin A