Serotonin in involuntary movement disorders.
Several recent studies have emphasized that serotonergic pathways in the CNS are intimately involved in the modulation of motor behavior, and in the pathophysiology of human involuntary movement disorders. These observations are supported by recent reports demonstrating large serotonergic innervation of the striatum and substantia nigra, and a close interaction between the activity of serotonergic neurons with the dopamine system in the striatum and nigra. In the following communication we summarize evidence demonstrating defective serotonergic functions in a number of human movement disorders and discuss their management with serotonergic drugs.
Sandyk
R
R
Department of Neurology, University of Arizona, Tucson 85724.
Fisher
H
H
D001479:Basal Ganglia / Q000502:physiology; D001480:Basal Ganglia Diseases / Q000503:physiopathology; D002490:Central Nervous System / Q000378:metabolism; D006801:Humans; D009069:Movement Disorders / Q000503:physiopathology*; D011985:Receptors, Serotonin / Q000502:physiology; D012701:Serotonin / Q000096:biosynthesis / Q000502:physiology*; D013378:Substantia Nigra / Q000502:physiology; D014836:Volition
D011985:Receptors, Serotonin; D012701:Serotonin