title: Exercise training improves early survival rate in diabetic rats submitted to acute coronary artery ligation.
abstract: This study was designed to test the hypothesis that the decreased early survival rate of diabetic rats submitted to acute experimental myocardial infarction could be improved by a previous training program. Male Wistar rats (+/- 200 g) were rendered diabetic with the i.v. injection of streptozotocin (45 mg/kg) but only those presenting one week later a tail-blood glucose value between 250-400 mg/dl were retained in the protocol. Diabetic and control rats were either kept sedentary or submitted to a progressive 10-week program of treadmill running. The left coronary artery was then ligated under ether anesthesia. Adequate occlusion was confirmed by an elevation of plasma CK-MB levels four hours later or by a toluidine blue injection technique in rats which died earlier. Since the first 20 minutes after such a procedure represents a most critical period for sudden death, the early survival rate was calculated for each group of rats and significance in differences was established with the Fisher's test. While the 27% early survival rate observed in sedentary diabetics was significantly lower (p = 0.02) than the 49% found in sedentary controls, this was completely alleviated by previous training in diabetic animals (50%; p = 0.018 vs sedentary diabetics and 0.623 vs sedentary controls). This beneficial effect of training was not found in nondiabetic animals.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Unité de Recherche sur le Diabète, Le Centre Hospitalier de l'Université Laval, Ste-Foy, Québec, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Nadeau
authors.forename: S
authors.initials: S
authors.lastname: Rousseau-Migneron
authors.forename: G
authors.initials: G
authors.lastname: Tancrède
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003331:Coronary Vessels / Q000503:physiopathology; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000503:physiopathology*; D007328:Insulin / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology*; D010805:Physical Conditioning, Animal; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D007328:Insulin