title: Prostacyclin deficiency in a young woman with recurrent thrombosis.
abstract: A young woman with recurrent deep venous thromboses and spontaneous abortions was studied. She suffered an ovarian infarction followed by aortic thrombosis and renal failure. Evidence for deficient prostacyclin production was found and she responded to treatment with a prostacyclin infusion. This syndrome is identical with that seen in women with the lupus anticoagulant, but the lupus anticoagulant was not detected and no other cause was identified.
authors.forename: J G
authors.initials: JG
authors.lastname: Lanham
authors.forename: M
authors.initials: M
authors.lastname: Levin
authors.forename: Z
authors.initials: Z
authors.lastname: Brown
authors.forename: A E
authors.initials: AE
authors.lastname: Gharavi
authors.forename: P A
authors.initials: PA
authors.lastname: Thomas
authors.forename: G C
authors.initials: GC
authors.lastname: Hanson
mesh_terms: D000026:Abortion, Habitual / Q000150:complications*; D000328:Adult; D001011:Aorta; D001158:Arteries / Q000378:metabolism; D001780:Blood Coagulation Tests; D011464:Epoprostenol / Q000096:biosynthesis / Q000172:deficiency*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D013577:Syndrome; D013924:Thrombophlebitis / Q000150:complications; D013927:Thrombosis / Q000150:complications*
chemical_list: D011464:Epoprostenol