A case of disseminated trichosporonosis: a case report and immunohistochemical identification of fungal elements.
Trichosporon beigelii was isolated from blood cultures of a 69-year-old Japanese male who had been treated for chronic myeloid leukaemia with cytotoxic agents and broad spectrum antibiotics. He died of sepsis 4 days after a positive blood culture was obtained. A postmortem examination revealed abundant budding yeasts and hyphae in sections of lung, liver, bone marrow and other organs. All the fungal elements in the sections were identified as Trichosporon species by their histological features and by immunohistochemical findings using rabbit antiserum raised against the strain isolated from the patient.
Mochizuki
T
T
Department of Dermatology, Shiga University of Medical Science, Otsu, Japan.
Sugiura
H
H
Watanabe
S
S
Takada
M
M
Hodohara
K
K
Kushima
R
R
D000368:Aged; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications*; D008297:Male; D008854:Microscopy, Electron; D003904:Mitosporic Fungi / Q000302:isolation & purification*; D009181:Mycoses / Q000097:blood / Q000150:complications / Q000382:microbiology*; D014250:Trichosporon / Q000254:growth & development / Q000302:isolation & purification* / Q000648:ultrastructure