[Dependence of the bactericidal activity and mutant selection of 4-quinolones on their serum concentration levels].
In an in vitro system, bacterial cultures were exposed to concentrations following the kinetics of 4-quinolones in human serum. Both killing kinetics of staphylococci and enterococci and selection of resistant mutants were shown to be influenced by the pharmacokinetik parameters of the individual substances.
Bauernfeind
A
A
Petermüller
C
C
Heinrich
B
B
Gablac
R
R
D000900:Anti-Bacterial Agents / Q000097:blood* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D013293:Enterococcus faecalis / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009643:Norfloxacin / Q000031:analogs & derivatives* / Q000097:blood* / Q000494:pharmacology; D015242:Ofloxacin; D010078:Oxazines / Q000097:blood* / Q000494:pharmacology; D015366:Pefloxacin; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D010078:Oxazines; D015366:Pefloxacin; D015242:Ofloxacin; D009643:Norfloxacin
Abhängigkeit von Bakterizidie und Mutantenselektion bei 4-Chinolonen von deren Serumkonzentrationsverläufen.