[Effect of electrostimulation of the hypothalamus on the immunological reactivity of rats with 7,12-dimethylbenz[a]anthracene-induced tumors].
Experiments on Wistar male rats established that electrostimulation of the area of the posterior hypothalamic nuclei 2.5 months after administration of 7,12-dimethylbenz(a)anthracene into the femur muscle restrained to a considerable extent the inhibitory effect of the carcinogen on the immune reactivity. The reactivity was estimated by the amount of antibody-forming and rosette-forming cells in the spleen, thymus, lymph nodes and by the activity of DNA synthesis in the cells of these organs. The effect of hypothalamus electrostimulation may be a determinant in the mechanism of the inhibitory action of chemical carcinogenesis.
Vinnitskiĭ
V B
VB
Shevchenko
I N
IN
Isaeva
E G
EG
Lapteva
N A
NA
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D000937:Antigen-Antibody Reactions / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004558:Electric Stimulation / Q000379:methods; D007031:Hypothalamus / Q000502:physiology*; D008221:Lymphoid Tissue / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012397:Rosette Formation; D013997:Time Factors
D015127:9,10-Dimethyl-1,2-benzanthracene; D004247:DNA
Vliianie élektrostimuliatsii gipotalamusa na immunologicheskuiu reaktivnost' krys s opukholiami, indutsirovannymi 7,12-dimetilbenz[a]antratsenom.