title: Protective effects of corticosteroids in contrast material anaphylaxis.
abstract: A prospective, randomized study of the potential protective effects of corticosteroids administered as pretreatment against contrast material (CM) reactions is reported. Patients (n = 6,763) from multiple institutions received either a single dose of steroids (32 mg of oral methylprednisolone, approximately 2 hours before CM challenge), a double dose (32 mg approximately 12 hours and 2 hours before CM challenge), or placebo. All contrast injections were with ionic media and were given intravenously. The two-dose (but not the one-dose) corticosteroid regimen provided significant protection. The effect on reaction incidences of a number of historical variables is also tabulated.
authors.affiliation: Department of Radiology, UCSD School of Medicine, La Jolla 92093-0632.
authors.forename: E C
authors.initials: EC
authors.lastname: Lasser
authors.forename: C C
authors.initials: CC
authors.lastname: Berry
authors.forename: L B
authors.initials: LB
authors.lastname: Talner
authors.forename: L C
authors.initials: LC
authors.lastname: Santini
authors.forename: E K
authors.initials: EK
authors.lastname: Lang
authors.forename: F H
authors.initials: FH
authors.lastname: Gerber
authors.forename: H O
authors.initials: HO
authors.lastname: Stolberg
mesh_terms: D000707:Anaphylaxis / Q000517:prevention & control*; D003287:Contrast Media / Q000009:adverse effects*; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use*; D015337:Multicenter Studies as Topic; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation
chemical_list: D003287:Contrast Media; D008775:Methylprednisolone