Carotid artery wall properties in normotensive and borderline hypertensive subjects of various ages.
The vessel wall properties of the common carotid artery were studied noninvasively in normotensive and borderline hypertensive male volunteers of various ages with the use of a multi-gate pulsed Doppler system. In the younger age group (20-35 y) both distensibility and cross-sectional compliance were significantly less in the borderline hypertensive group. In the older borderline hypertensive subjects (50-69 y) distensibility (p less than 0.05) and cross-sectional compliance (p = 0.06) were also less than in the control subjects. The reduced distensibility and cross-sectional compliance likely result from a decrease in arterial wall elasticity because the relative increase in common carotid artery diameter during systole is diminished in borderline hypertensives, despite the fact that their pulse pressure is similar to or higher than that in control subjects. The less pronounced differences in vessel wall properties between borderline hypertensive and normotensive volunteers in the older age group may be a consequence of the changes in these properties with age, partly masking the alterations due to borderline hypertension. Since the stiffer behavior of the common carotid artery in borderline hypertensives is associated with relatively slight changes in blood pressure, the question can be raised whether the alterations in arterial wall properties are really a result of the elevated arterial blood pressure; these alterations might develop independent of the blood pressure elevation.
Van Merode
T
T
Department of Physiology, University of Limburg, Maastricht, The Netherlands.
Hick
P J
PJ
Hoeks
A P
AP
Rahn
K H
KH
Reneman
R S
RS
D000328:Adult; D000368:Aged; D000375:Aging; D001794:Blood Pressure; D001810:Blood Volume; D002339:Carotid Arteries / Q000033:anatomy & histology* / Q000502:physiology; D004548:Elasticity; D006801:Humans; D006973:Hypertension / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013599:Systole; D014463:Ultrasonography / Q000379:methods