Detection of alpha-transducin in retinal rods but not cones.
The distribution in chicken retina of the alpha subunit of transducin, the guanine nucleotide--binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3',5'-monophosphate phosphodiesterase, was determined with the aid of a specific antiserum. alpha-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to alpha-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.
Grunwald
G B
GB
Gierschik
P
P
Nirenberg
M
M
Spiegel
A
A
D000818:Animals; D000918:Antibody Specificity; D002417:Cattle; D002645:Chickens; D005455:Fluorescent Antibody Technique; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008253:Macaca mulatta; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000276:immunology / Q000378:metabolism*; D010786:Photoreceptor Cells / Q000378:metabolism*; D012160:Retina / Q000254:growth & development / Q000378:metabolism; D014018:Tissue Distribution; D015293:Transducin
D046911:Macromolecular Substances; D008565:Membrane Proteins; D019204:GTP-Binding Proteins; D015293:Transducin