[Bone marrow transplant in acute leukemia in children. Experience of the Pesaro group].
Thirty children aged one to 15 years with acute lymphoblastic leukemia and acute nonlymphoblastic leukemia were transplanted from HLA matched donors using two different preparative regimens: 18 patients were prepared with cyclophosphamide and Total Body Irradiation while 12 patients received Busulphan and Cyclophosphamide. 15 patients survive 7 to 74 months after transplant. Although for the second group of patients a longer follow-up is needed in order to evaluate eradication of the disease and long-term toxicity, the combination chemotherapy alone results in improving survival (71% versus 28%) and decreasing relapse rate (30% versus 56%) compared with the group of patients who received the chemoradiotherapy regimen. Also the incidence of Interstitial Pneumonia has been lower in the group receiving chemotherapy alone. We conclude that this protocol is generally well tolerated in young patients, without increasing secondary toxicity.
Giardini
C
C
Divisione Ematologica e Centro Trapianto di Midollo Osseo di Muraglia--Ospedale di Pesaro.
Polchi
P
P
Lucarelli
G
G
Galimberti
M
M
Moretti
L
L
D000293:Adolescent; D016026:Bone Marrow Transplantation; D002066:Busulfan / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007223:Infant; D007558:Italy; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D011292:Premedication; D011379:Prognosis; D014916:Whole-Body Irradiation
D003520:Cyclophosphamide; D002066:Busulfan
Il trapianto di midollo osseo nelle leucemie acute in età pediatrica. Esperienza del gruppo di Pesaro.