Clinical application of epiderm growth factor in patients with most severe eye burns.
20 eyes of 11 patients suffering from most severe eye burns of grade 4 or worse were treated in addition to various other drugs with epiderm growth factor (EGF) or placebo in a double-blind test. Among 10 eyes treated with EGF, 6 achieved complete regeneration of the corneal epithelium, and 1 additional case, of the conjunctival epithelium. Among the eyes receiving placebo, only 3 out of 10 healed; all of them were also treated with fibronectin. Although in these very difficult cases EGF could not be investigated as a single therapy, and various other undefined factors may have been effective, in the extended course of the disease the period of EGF treatment was marked by a significant better regeneration of the epithelium.
Reim
M
M
Abteilung Augenheikunde, Medizinische Fakultät, Rheinisch-Westfälische Technische Hochschule Aachen.
Kehrer
T
T
Lund
M
M
D002057:Burns, Chemical / Q000188:drug therapy; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004815:Epidermal Growth Factor / Q000627:therapeutic use*; D005126:Eye Burns / Q000188:drug therapy*; D005353:Fibronectins / Q000627:therapeutic use; D006801:Humans
D005353:Fibronectins; D004815:Epidermal Growth Factor