title: Effects of insulin on renal electrolyte handling.
abstract: It has been recognized that insulin, beside its functions on extrarenal metabolic processes, also modulates the renal handling of different electrolytes. The effects of one intravenously administered bolus (0.1 U/kg BW) of insulin on renal electrolyte handling were investigated in children. Insulin without affecting the filtration rate of creatinine and the urine flow rate resulted in significant increases in urinary calcium (3.56 +/- 0.80 vs. 7.48 +/- 0.80 mumol/min/1.73 m2) and magnesium (2.44 +/- 0.41 vs. 4.29 +/- 0.5 mumol/min/1.73 m2) and a fall in potassium excretion (53.25 +/- 13.17 vs. 23.71 +/- 4.21 mumol/min/1.73 m2). Phosphate excretion showed an initial fall followed by a more than twofold increase afterwards (6.52 +/- 0.92 vs. 3.14 +/- 0.92 and 15.29 +/- 3.82 mumol/min/1.73 m2, respectively). On the other hand, urinary sodium excretion was unaffected (171.21 +/- 27.22 vs. 166.23 +/- 22.86 mumol/min/1.73 m2). Our data show that insulin may modulate electrolyte homeostasis by inducing changes in their renal tubular handling.
authors.affiliation: First Department of Pediatrics, Semmelweis University, Budapest, Hungary.
authors.forename: Z
authors.initials: Z
authors.lastname: Ocsényi
authors.forename: T
authors.initials: T
authors.lastname: Tulassay
authors.forename: M
authors.initials: M
authors.lastname: Miltényi
authors.forename: A
authors.initials: A
authors.lastname: Szabó
mesh_terms: D002648:Child; D004573:Electrolytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male
chemical_list: D004573:Electrolytes; D007328:Insulin