title: Immunoperoxidase studies by monoclonal antibody B72.3 applied to breast aspirates: diagnostic considerations.
abstract: The purpose of this study was to determine the reactivity of monoclonal antibody (MAb) B72.3 when applied directly to aspiration biopsy cytology (ABC) of the breast in the following conditions: (1) infiltration lobular carcinoma; (2) fibrocystic disease; (3) fibroadenoma; and (4) apocrine cysts. Nine of ten aspirates from infiltrating lobular carcinoma were positive in these assays, while 21 of 22 benign cases reacted negatively. The single false-positive benign aspirate manifested a staining pattern characteristic of apocrine cells. This study demonstrates that the MAb B72.3 can be employed as a potentially valuable diagnostic adjunct. It can be used on stained aspirates to assist in the interpretation of ABC from breast lesions.
authors.affiliation: State University of New York, Stony Brook.
authors.forename: J
authors.initials: J
authors.lastname: Lundy
authors.forename: T S
authors.initials: TS
authors.lastname: Kline
authors.forename: M
authors.initials: M
authors.lastname: Lozowski
authors.forename: S
authors.initials: S
authors.lastname: Chao
mesh_terms: D000911:Antibodies, Monoclonal; D001707:Biopsy, Needle; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005348:Fibrocystic Breast Disease / Q000175:diagnosis*; D006801:Humans; D007124:Immunoenzyme Techniques
chemical_list: D000911:Antibodies, Monoclonal