title: Biological consequences of drug sulphoxidation.
abstract: The addition of an oxygen atom to the sulphur centre of a compound, with the formation of a polarized S-O moiety, alters the physical and chemical properties of the molecule and can profoundly influence its biological activity, its disposition within the body and its potential fate. Examples are given to illustrate these points.
authors.affiliation: Department of Pharmacology and Toxicology, St. Mary's Hospital Medical School, Paddington, London, U.K.
authors.forename: S C
authors.initials: SC
authors.lastname: Mitchell
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D013454:Sulfoxides / Q000378:metabolism*
chemical_list: D004364:Pharmaceutical Preparations; D013454:Sulfoxides