title: [Infections and bone marrow autograft carried out for leukemias in children. Apropos of 47 cases].
abstract: This study included 44 children undergoing autologous marrow transplantation for leukemia between August 1979 and June 1987. Three of them received a second transplant. In the phase of neutropenia, 38 children presented with fever. Nineteen septicemia occurred (13 Gram positive cocci, 6 Gram negative bacteria), and 2 interstitial pneumonitis were observed. All children with documented infection or a fever of unknown origin recovered after treatment, except 3, who died from infection. The latest antimicrobial therapy used was a combination of an aminoglycoside and a third generation cephalosporin. When necessary, vancomycin or amphotericin B were added. After engraftment (granulocyte count greater than 0.5 X 10(9)/l) 14 septicemia (which recovered) and 10 herpes zoster infections were observed. Only one patient died of infection (herpes zoster with encephalitis).
authors.affiliation: Unité d'Hématologie Pédiatrique, Centre de Transfusion Sanguine, CHU, Besançon.
authors.forename: D
authors.initials: D
authors.lastname: Amsallem
authors.forename: E
authors.initials: E
authors.lastname: Plouvier
authors.forename: J M
authors.initials: JM
authors.lastname: Estavoyer
authors.forename: J
authors.initials: J
authors.lastname: Leroy
authors.forename: D
authors.initials: D
authors.lastname: Talon
authors.forename: M
authors.initials: M
authors.lastname: Lab
authors.forename: P
authors.initials: P
authors.lastname: Hervé
authors.forename: A
authors.initials: A
authors.lastname: Noir
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control*; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000601:surgery*; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D013242:Sterilization; D014777:Virus Diseases / Q000188:drug therapy / Q000209:etiology
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Infections et autogreffes de moelle osseuse réalisées pour leucémies chez l'enfant. A propos de 47 observations.