[Analysis of the products of ergosta-7,22-dien-3-beta-ol biotransformation by a Nocardia erythropolis culture].
The products of biotransformation by Nocardia erythropolis-402 of the microbial sterol ergosta-7,22-dien-3 beta-ol isolated from a Saccharomyces cerevisiae mutant were studied. The products were identified as ergosta-7,22-dien-3-one and ergosta-7,22-dien-17 alpha-ol-3-one by thin-layer chromatography, UV-spectrophotometry and mass-spectroscopy. It was found that the existence of 7-8 double bond slowed down the cleavage of the sterol side chain. The absence of 5-6 double bond prevents the formation of delta 4-3-ketosystem of coupled bonds.
Klimashina
M M
MM
Viktorovskiĭ
I V
IV
Mikhaĭlova
N P
NP
V'iunov
K A
KA
D001711:Biotransformation; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics; D009154:Mutation; D009615:Nocardia / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics
C059437:ergosta-7,22-dien-17-ol-3-one; C059439:ergost-7,22-diene-3-ol; C059438:ergosta-7,22-dien-3-ol; D004875:Ergosterol
Analiz produktov biotransformatsii érgosta-7,22-dien-3-beta-ola kul'turoĭ Nocardia erythropolis.