Conditioned rotational behavior in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra.
Rats with unilateral 6-hydroxydopamine lesions of the substantia nigra were given drug treatments which induced rotational behavior either ipsilateral (2.0 mg/kg D-amphetamine) or contralateral (0.5 mg/kg apomorphine) in a classical conditioning paradigm. Four days after four drug-environment pairings the rats rotated ipsilateral in the amphetamine-associated environment and contralateral in the apomorphine-associated environment. 6-OHDA-lesioned rats which received only drug or environment exposure exhibited a slight tendency to rotate ipsilateral in each environment. This conditioning of drug-induced rotational behavior may offer a useful model for the study of brain mechanisms in classical conditioning.
Carey
R J
RJ
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D012399:Rotation; D013378:Substantia Nigra / Q000187:drug effects*
D006892:Hydroxydopamines; D016627:Oxidopamine; D001058:Apomorphine; D003913:Dextroamphetamine