The effects of fetal exchange transfusion with a red blood cell substitute.
Isovolemic exchange transfusion in the fetal lamb in utero was performed with the use of Fluosol-DA (20%), a perfluorochemical erythrocyte substitute. With maternal hyperoxygenation, a physiologic PO2 was maintained in the fetal lambs, although the total fetal oxygen content decreased as the hematocrit dropped. Because of the oxygen-carrying properties of the perfluorochemical emulsion, the fraction of fetal oxygen carried in the dissolved state increased significantly when compared with that in controls that received saline solution.
Ambrose
A
A
Cefalo
R C
RC
Bowes
W A
WA
D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage*; D002245:Carbon Dioxide / Q000097:blood; D004338:Drug Combinations / Q000008:administration & dosage; D005078:Exchange Transfusion, Whole Blood / Q000379:methods*; D005260:Female; D005333:Fetus / Q000502:physiology*; D005466:Fluorocarbons / Q000008:administration & dosage*; D006439:Hemodynamics; D006895:Hydroxyethyl Starch Derivatives; D008431:Maternal-Fetal Exchange; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D011817:Rabbits; D012119:Respiration
D001802:Blood Substitutes; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D002245:Carbon Dioxide; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D010100:Oxygen