Stress-induced proteins and the immune response to leprosy.
Mycobacterial antigens which play a major role in humoral and cell-mediated immune recognition are related to proteins which are induced in response to stress stimuli. The potential involvement of stress-induced proteins in infectious disease and in autoimmune responses is discussed.
Young
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MRC Tuberculosis and Related Infections Unit, Hammersmith Hospital, London, UK.
D000595:Amino Acid Sequence; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000276:immunology; D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology*; D001483:Base Sequence; D005786:Gene Expression Regulation; D006360:Heat-Shock Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007918:Leprosy / Q000276:immunology* / Q000378:metabolism; D008969:Molecular Sequence Data; D009166:Mycobacterium leprae / Q000235:genetics / Q000276:immunology*; D012689:Sequence Homology, Nucleic Acid; D013312:Stress, Physiological / Q000378:metabolism*
D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D006360:Heat-Shock Proteins