The role of tumor necrosis factor and interleukin 1 in the immunoinflammatory response.
Monocytes and tissue macrophages produce at least two groups of protein mediators of inflammation, interleukin 1 (IL-1) and tumor necrosis factor (TNF). Recent studies have emphasized that TNF and IL-1 modulate the inflammatory function of endothelial cells, leukocytes, and fibroblasts. Although these cytokines share a number of biologic properties, they have quite distinct gene and protein structures. It is our purpose to focus on the role of these mediators in inflammation.
Larrick
J W
JW
Department of Immunology, Cetus Corp, Palo Alto, California 94303.
Kunkel
S L
SL
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000503:physiopathology; D007375:Interleukin-1 / Q000502:physiology*; D008969:Molecular Sequence Data; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha