[Can one increase the analgesic effect of Mobilisin ointment by iontophoresis? Placebo controlled triple cross-over double-blind study].
In a double-blind, three-way crossover trial, with placebo controls on 41 patients with inflammatory rheumatic disorders (mono- or oligoarticular forms), the analgesic action of Mobilisin ointment, with or without iontophoresis, was significantly stronger than after iontophoresis alone or after placebo. Iontophoresis did not potentiate the analgesic properties of Mobilisin. The pain was scored on VAS in intervals 30 min, 1, 2, 4, 6, 8 h after application. The duration of analgesic effect after Mobilisin procedures was 6.5 h on average, which was significantly longer than after iontophoresis alone or after placebo.
Pavelka
K
K
Rheumaforschungsinstitut Prag.
Pavelka
K
K
Svarcova
J
J
Vácha
J
J
Trnavský
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005439:Flufenamic Acid / Q000008:administration & dosage*; D006801:Humans; D007478:Iontophoresis; D008297:Male; D008875:Middle Aged; D009824:Ointments; D010003:Osteoarthritis / Q000188:drug therapy*; D010147:Pain Measurement; D011897:Random Allocation
D009824:Ointments; D005439:Flufenamic Acid
Kann man die analgetische Wirkung der Mobilisin-Salbe durch die Iontophorese verstärken? Plazebokontrollierte Dreifach-cross-over-Doppelblindstudie.