[Effect of silimarine on activity of lysosomal proteinases in the liver and kidneys during tetramethylthiuram disulfide administration].
Total and nonsedimented activities of lysosomal proteinases were studied in rat liver and kidney tissues after administration of silimarine simultaneously with tetramethylthiuram disulfide (TMTD). Silimarine did not affect the pattern of alterations in total activity of lysosomal proteinases, caused by the TMTD treatment, but the nonsedimented activity of the enzymes studied was normalized. Silimarine appears to exhibit the membrane-stabilizing effect.
Tabagari
S I
SI
Shubitidze
T M
TM
Abdushelishvili
G V
GV
D000818:Animals; D010450:Endopeptidases / Q000378:metabolism*; D004789:Enzyme Activation; D005419:Flavonoids / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D011480:Protease Inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D012838:Silymarin / Q000494:pharmacology*; D013859:Thiocarbamates / Q000633:toxicity*; D013893:Thiram / Q000633:toxicity*
D005419:Flavonoids; D011480:Protease Inhibitors; D012838:Silymarin; D013859:Thiocarbamates; D013893:Thiram; D010450:Endopeptidases
Vliianie silimarina na aktivnost' lizosomal'nykh proteinaz pecheni i pochek pri vvedenii tetrametiltiuramdisul'fida.