title: Experimental induction of rheumatoid factor and joint lesions in rabbits after intravenous injections of killed bacteria.
abstract: Rabbits receiving repeated intravenous injections of killed bacteria (Escherichia coli or Bacillus subtilis) developed IgM rheumatoid factor which reacted with autologous heat-aggregated IgG. In addition, 5/7 'Old English' and 7/8 'Sandy Lop' rabbits receiving killed E. coli developed rheumatoid-like synovial lesions. 'Old English' rabbits developed lesions of a more severe nature. Three of eight 'Sandy Lop' rabbits injected with killed B. subtilis had high levels of rheumatoid factor but only mild joint lesions.
authors.forename: A C
authors.initials: AC
authors.lastname: Hanglow
authors.forename: C J
authors.initials: CJ
authors.lastname: Welsh
authors.forename: P
authors.initials: P
authors.lastname: Conn
authors.forename: J M
authors.initials: JM
authors.lastname: Pitts
authors.forename: A
authors.initials: A
authors.lastname: Rampling
authors.forename: R R
authors.initials: RR
authors.lastname: Coombs
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D001412:Bacillus subtilis; D004926:Escherichia coli; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007592:Joint Diseases / Q000209:etiology / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D011817:Rabbits; D012217:Rheumatoid Factor / Q000096:biosynthesis*; D013582:Synovial Fluid / Q000166:cytology
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012217:Rheumatoid Factor