title: Primary drug resistance to both rifampicin and dapsone in a paucibacillary leprosy patient.
abstract: A thirty-one year old male patient was diagnosed and treated for a pure or better primary neuritic case of leprosy with dapsone (100 mg daily for 2 years) and rifampicin (600 mg daily for 6 months). From the very outset, the patient did not show any improvement; on the top of it, he subsequently, developed a cutaneous patch, which on histopathological examination, revealed classical features of BT leprosy. Acid-fast bacilli were absent both in skin slit smear and histologic section. A primary resistance to both dapsone and rifampicin, even in paucibacillary patient, is speculated.
authors.affiliation: Department of Dermatology and Venereology, Maulana Azad Medical College, Pant Hospitals, New Delhi.
authors.forename: R V
authors.initials: RV
authors.lastname: Koranne
authors.forename: G
authors.initials: G
authors.lastname: Srivastava
mesh_terms: D000328:Adult; D003622:Dapsone / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D006801:Humans; D015441:Leprosy, Tuberculoid / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D009166:Mycobacterium leprae / Q000187:drug effects*; D012293:Rifampin / Q000627:therapeutic use*
chemical_list: D003622:Dapsone; D012293:Rifampin