Haemodynamic and humoral reaction in arterial hypertension during acute blood pressure lowering induced by nitroglycerin.
The aim of the study was to test whether there are typical changes in haemodynamics and humoral regulation in untreated hypertensives compared to normotensives with acute lowering of blood pressure (and venous return) induced by nitroglycerin (NTG). 23 hypertensives were investigated by radiocardiography and microcatheterization of the pulmonary artery as well as by means of humoral analyses in comparison to 10 normotensives. After performing the studies at rest and during exercise, 0.8 mg NTG was given and the investigations were repeated. There were only insignificant differences in cardiac output and left ventricular filling pressure (PAEDP) at rest and during exercise between both groups. The pressure reductions due to NTG were also similar. Plasma renin activity and plasma kallikrein did not differ in hypertensives and normotensives either at rest and during exercise or after NTG. The prostaglandins (PgE, PgF2-alpha, PgI) were extremely variable. In hypertensives, only PgI was decreased, with increase after NTG, at rest. Thus, PgI is the only humoral indicator participating in blood pressure lowering induced by NTG.
Eisenberg
B M
BM
Frille
J
J
Linss
G
G
Günther
K H
KH
Taube
C
C
Strangfeld
D
D
Förster
W
W
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D007610:Kallikreins / Q000097:blood; D008297:Male; D005996:Nitroglycerin / Q000494:pharmacology*; D005082:Physical Exertion; D011453:Prostaglandins / Q000097:blood; D012083:Renin / Q000097:blood
D011453:Prostaglandins; D007610:Kallikreins; D012083:Renin; D005996:Nitroglycerin