[Thromboembolism risk factors in kidney transplant patients with secondary erythrocytosis in relation to hemorheologic aspects].
In patients undergoing dialysis and patients who underwent a transplantation of a kidney cardiovascular risk factors increase the lethality to 50%. A secondary polyglobulia (Pg) after transplantation enhances the risks of thromboembolism. In 180 patients who underwent a transplantation we saw in 11% a polyglobulia with 50% of thromboembolic complications. For the study of the secondary polyglobulia and other risk factors haemorheologic investigations were carried out on 20 patients who underwent a transplantation with Pg, 10 patients who underwent a transplantation without Pg and 19 healthy test persons. In patients with secondary polyglobulia we found a slightly increased plasma viscosity and an increase of the aggregation of the erythrocytes without decrease of their deformability. A decreased deformability of the erythrocytes in patients who underwent a transplantation with Pg and diabetes results in an additional risk, as was casuistically observed on a patient with 2 amputations of the legs and 2 myocardial infarctions. Our findings confirm the correctness of the isovolaemic haemodilution for the avoidance of additional cardiovascular complications in patients who underwent a transplantation of a kidney with polyglobulia.
Koall
W
W
Klinik und Poliklinik für Innere Medizin, Martin-Luther-Universität Halle-Wittenberg.
Schäbitz
J
J
Kunsch
R
R
Nilius
R
R
D000328:Adult; D001809:Blood Viscosity; D004903:Erythrocyte Aggregation; D004907:Erythrocyte Deformability; D005260:Female; D006400:Hematocrit; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D011086:Polycythemia / Q000097:blood*; D011183:Postoperative Complications / Q000097:blood*; D012212:Rheology; D012307:Risk Factors; D013923:Thromboembolism / Q000097:blood*
Untersuchungen zum Problem thromboembolischer Risikofaktoren bei Nierentransplantierten mit sekundärer Polyglobulie unter hämorheologischen Aspekten.