title: Treatment of esophageal anastomotic leakages after cancer resection. The role of total parenteral nutrition.
abstract: A series of 16 cases of esophageal anastomotic leakages after cancer resection observed from 1978 to 1982 is analyzed in a retrospective manner. Eight patients related to the period 1978 to 1980 (series A) were treated with emergency surgery while the remaining eight patients observed from 1980 to 1982 (series B) were treated conservatively with total parenteral nutrition (TPN) and complete fasting. Seven patients from series A eventually died postoperatively and one patient had a good recovery after emergency reintervention. In the series B six patients left the hospital with complete healing of the anastomotic leaks after 27.2 +/- 13.5 days of TPN and complete fasting, while failure of the treatment was observed in two patients who died from septic mediastinitis and acute respiratory failure. Different incidence of positive clinical results in Series A and B was statistically significant (p less than 0.01). The role of TPN and complete fasting will be discussed as the primary approach for the management of this severe complication, taking in consideration the suture line drainage and the control of infection.
authors.forename: E B
authors.initials: EB
authors.lastname: Riboli
authors.forename: S
authors.initials: S
authors.lastname: Bertoglio
authors.forename: G
authors.initials: G
authors.lastname: Arnulfo
authors.forename: A
authors.initials: A
authors.lastname: Terrizzi
mesh_terms: D004938:Esophageal Neoplasms / Q000601:surgery*; D004947:Esophagus / Q000601:surgery; D005215:Fasting; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D013274:Stomach Neoplasms / Q000601:surgery*; D013529:Surgical Wound Dehiscence / Q000628:therapy*