title: Infectious problems in elective colorectal surgery: a multi-centre study. The Norwegian Gastro-Intestinal Group (NORGAS).
abstract: A prospective, multi-centre study was carried out in 572 patients undergoing colorectal surgery to investigate the effectiveness of a standardized antibiotic regimen as prophylaxis against post-operative infectious problems. Surgical departments used a single intravenous dose of 400 mg doxycycline plus 1600 mg tinidazole given 1-hour pre-operatively or at induction of anaesthesia. Patients were evaluated clinically 3, 7 and 15 days after surgery. Analysis of the results showed that 18 (3.1%) developed surgical infectious complications. Only 3 (0.5%) of the 21 patients who died during the hospital stay or observation period did so because of septic complications. No serious side-effects were seen. Overall compliance rate with the regimen was 96.9%. There were no signs of declining antibiotic efficacy in hospitals which had been using this regimen for up to 10 years.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000382:microbiology / Q000517:prevention & control*; D002648:Child; D003108:Colonic Diseases / Q000601:surgery*; D004318:Doxycycline / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009593:Nitroimidazoles / Q000627:therapeutic use*; D009664:Norway; D010349:Patient Compliance; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication; D011446:Prospective Studies; D012002:Rectal Diseases / Q000601:surgery*; D014011:Tinidazole / Q000627:therapeutic use*
chemical_list: D009593:Nitroimidazoles; D014011:Tinidazole; D004318:Doxycycline