title: On changes in pancreas cytomorphometry, serum insulin and metabolic adjustments induced by long term orchidectomy and substitutive therapy with testosterone in dogs.
abstract: Mongrel, male, fasted, unanesthetized dogs under the following alternative treatments: 1) nil, 2) orchidectomy 4 months before the study, 3) orchidectomy 10 months in advance, 4) orchidectomy like in (3) followed by i.m. propylenglycol treatment, 0.05 ml/kg body wt./day, 15 days (vehicle controls, and 5) testosterone hemisuccinate in propylenglycol, 0.75 mg in 0.05 ml/kg body wt./day, for 15 days, were used in this study. Pancreas slices of animals of every group were stained with immunoperoxidase. The animals were fasted, anesthetized for pancreas removal. Pancreatic section mean absorbance was estimated in a Zeiss cytospectrophotometer with a coupled computer. Blood sugar (BS) and both serum, immunoreactive insulin (IRI) and free fatty acids (FFA) were assayed in these.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Buenos Aires, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Renauld
authors.forename: I
authors.initials: I
authors.lastname: Von Lawzewitsch
authors.forename: R C
authors.initials: RC
authors.lastname: Sverdlik
authors.forename: R L
authors.initials: RL
authors.lastname: Pérez
authors.forename: R R
authors.initials: RR
authors.lastname: Rodríguez
authors.forename: V G
authors.initials: VG
authors.lastname: Foglia
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D004285:Dogs; D005227:Fatty Acids / Q000097:blood*; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007515:Islets of Langerhans / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009919:Orchiectomy; D013739:Testosterone / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D005227:Fatty Acids; D007328:Insulin; D013739:Testosterone