title: Continuous flow ventilation without respiratory movement in cat, dog and human.
abstract: The insufflation of oxygen at 1 litre kg-1 min-1 via two endobronchial catheters (called continuous flow ventilation (CFV)) maintained a normal PaCO2 and a constant PaO2 in anaesthetized paralysed dogs and in five out of seven cats. In two cats with a high carbon dioxide production, CFV failed to maintain carbon dioxide homeostasis since gas flows greater than 1 litre kg-1 min-1 caused thoracic distension and a decrease in arterial pressure. In five patients, endobronchial insufflation of oxygen 0.5 litre kg-1 min-1 caused approximately a 30% decrease in the increase in PaCO2 compared with apnoeic oxygenation (P less than 0.05) during a period of 6 min. CFV at 1 litre kg-1 min-1 can be used for physiological measurement without respiratory movement while maintaining blood-gas homeostasis in dogs and in cats with a normal carbon dioxide production. Ethical constraints have so far prevented the investigation of the effects of comparable gas flows in man.
authors.forename: A
authors.initials: A
authors.lastname: Perl
authors.forename: J G
authors.initials: JG
authors.lastname: Whitwam
authors.forename: M K
authors.initials: MK
authors.lastname: Chakrabarti
authors.forename: V M
authors.initials: VM
authors.lastname: Taylor
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000502:physiology; D002415:Cats; D004285:Dogs; D006706:Homeostasis; D006801:Humans; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage* / Q000502:physiology; D012119:Respiration; D012121:Respiration, Artificial
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen