title: Influence of different indwelling lines on the measurement of blood cyclosporin A levels.
abstract: We studied in vivo and in vitro the possible influence of the indwelling line on the measurement of cyclosporin A (CSA) levels. CSA levels measured in samples taken from the catheter lumen used for CSA administration were significantly higher than those taken either from a second lumen or from a peripheral vein. Reversible fixation of the drug to the catheter walls might explain this alteration. The degree of fixation varies for different types of plastic material.
authors.affiliation: Postgraduate School of Hematology, Hospital Clinic, University of Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Carreras
authors.forename: M
authors.initials: M
authors.lastname: Lozano
authors.forename: R
authors.initials: R
authors.lastname: Deulofeu
authors.forename: S
authors.initials: S
authors.lastname: Roman
authors.forename: A
authors.initials: A
authors.lastname: Grañena
authors.forename: C
authors.initials: C
authors.lastname: Rozman
mesh_terms: D016026:Bone Marrow Transplantation; D002406:Catheterization, Peripheral; D002408:Catheters, Indwelling; D003524:Cyclosporins / Q000008:administration & dosage / Q000097:blood*; D006801:Humans
chemical_list: D003524:Cyclosporins