The influence of phagocytic stimuli on the expression of HLA-DR antigens; role of reactive oxygen intermediates.
Human peripheral blood mononuclear cells show after one day of culture with opsonized zymosan a decreased expression of HLA-DR (but not HLA-A, B, C) antigens, which can be prevented by the scavenger of reactive oxygen intermediates beta-carotene, or superoxide dismutase or indomethacin. Mononuclear cells of a patient with a heterozygous form of chronic granulomatous disease show no alterations in HLA-DR antigen expression after culture with opsonized zymosan. Possible roles of reactive oxygen intermediates or prostaglandins in the modulation of HLA-DR antigens are discussed.
Gruner
S
S
Volk
H D
HD
Falck
P
P
Von Baehr
R
R
D000328:Adult; D000938:Antigen-Presenting Cells / Q000502:physiology; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D002338:Carotenoids / Q000494:pharmacology; D006680:HLA Antigens / Q000032:analysis; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008163:Luminescent Measurements; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D010587:Phagocytosis; D013482:Superoxide Dismutase / Q000494:pharmacology; D015054:Zymosan / Q000494:pharmacology; D019207:beta Carotene
D001095:Arachidonic Acids; D006680:HLA Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D019207:beta Carotene; D016718:Arachidonic Acid; D002338:Carotenoids; D015054:Zymosan; D013482:Superoxide Dismutase; D010100:Oxygen; D007213:Indomethacin