Effect of contrast media on prostaglandin synthesis in vivo.
Since systemic reactions to contrast media (CM) in patients often resemble pathophysiologic conditions associated with prostaglandin metabolites prostacyclin (PGI2), and thromboxane B2 (TXB2), plasma levels of these mediators are likely to provide an index of CM pathogenesis. In this study, patients undergoing peripheral arteriography were injected either with a hyperosmolal CM sodium diatrizoate or with a newer low osmolal CM, iohexol. Arterial blood samples were collected before and after the procedure. Prostacyclin and thromboxane were quantified as 6 ketoprostaglandin F1a (PGF1a) and TXB2 by using radioimmunoassay kits. Diatrizoate caused prostaglandin I2 (PGI2) release in 60% of patients, whereas 66% receiving iohexol also exhibited increased levels of PGI2 in their plasma. TXB2 concentration remained unchanged. No clinically adverse reactions were seen following the procedure. These results indicate that both high and low osmolality CM are capable of stimulating vascular endothelium, thereby causing prostacyclin release. Molecular mechanisms, however, remain to be determined.
Parvez
Z
Z
Radiology Research Laboratory, VA Hospital, Hines, Illinois 60141.
Marsan
R E
RE
Moncada
R
R
Patel
N
N
D000328:Adult; D003287:Contrast Media / Q000633:toxicity*; D003973:Diatrizoate / Q000633:toxicity; D004730:Endothelium, Vascular / Q000187:drug effects; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007472:Iohexol / Q000633:toxicity; D008297:Male; D009994:Osmolar Concentration; D011446:Prospective Studies; D013929:Thromboxane B2 / Q000096:biosynthesis*
D003287:Contrast Media; D003973:Diatrizoate; D007472:Iohexol; D013929:Thromboxane B2; D011464:Epoprostenol