title: Genotoxic effects of a variety of sterigmatocystin-related compounds in the hepatocyte/DNA-repair test and the Salmonella microsome assay.
abstract: The genotoxicity and mutagenicity of 11 fungal metabolites structurally related to sterigmatocystin were examined in the hepatocyte primary culture/DNA-repair test and the Salmonella microsome assay. 10 out of the mycotoxins, i.e. dihydrosterigmatocystin, 5-methoxysterigmatocystin, 5-methoxydihydrosterigmatocystin, 5,6-dimethoxysterigmatocystin, 5,6-dimethoxydihydrosterigmatocystin, sterigmatin, O-methylsterigmatocystin and O-acetylsterigmatocystin showed a positive response for DNA repair, suggesting their carcinogenic potency. 5-Methoxysterigmatocystin, 5,6-dimethoxysterigmatocystin demethylsterigmatocystin and O-acetylsterigmatocystin were mutagenic in TA100 of the bacterial mutagenicity assay with liver S9.
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: S
authors.initials: S
authors.lastname: Sugie
authors.forename: N
authors.initials: N
authors.lastname: Yoshimi
authors.forename: J
authors.initials: J
authors.lastname: Kitamura
authors.forename: M
authors.initials: M
authors.lastname: Niwa
authors.forename: T
authors.initials: T
authors.lastname: Hamasaki
authors.forename: K
authors.initials: K
authors.lastname: Kawai
mesh_terms: D000107:Acetylation; D016604:Aflatoxin B1; D000348:Aflatoxins / Q000494:pharmacology; D000818:Animals; D004260:DNA Repair / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008745:Methylation; D009152:Mutagenicity Tests; D051381:Rats; D011912:Rats, Inbred ACI; D012486:Salmonella typhimurium / Q000187:drug effects; D013241:Sterigmatocystin / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000494:pharmacology*
chemical_list: D000348:Aflatoxins; D014966:Xanthenes; D013241:Sterigmatocystin; D016604:Aflatoxin B1