The genetic determination of plasma apolipoprotein A-I levels measured by radioimmunoassay: a study of high-risk pedigrees.
Apolipoprotein A-I (apo A-I) is the major protein component of the high-density lipoprotein (HDL) found in all primates. Using radioimmunoassay, we measured plasma apo A-I levels in 97 individuals from 23 pedigrees ascertained through cases of hypertension or early coronary artery disease (CAD). Using complex segregation analysis, we found that a genetic model with both a single locus with a major effect and polygenic loci gave the best explanation for the distribution of apo A-I levels in these pedigrees. There was no evidence for a major locus effect on HDL cholesterol in these pedigrees. This is the first study to show evidence of a major effect of a single genetic locus on the quantitative variation of plasma apo A-I in a sample of pedigrees enriched for individuals at risk for CAD.
Moll
P P
PP
Sing
C F
CF
Williams
R R
RR
Mao
S J
SJ
Kottke
B A
BA
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000097:blood / Q000235:genetics*; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D004198:Disease Susceptibility; D005799:Genes, Dominant; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics; D008957:Models, Genetic; D010375:Pedigree; D011863:Radioimmunoassay; D012306:Risk
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A