Alterations in gastric mucosal microvascular endothelium in a stressed condition--relevance to gastric ulcerogenesis.
The present paper describes the morphological and functional alterations of the gastric mucosal microvascular endothelium under restraint-stressed condition. On the basis of the direct cholinergic innervation of capillaries and non-muscular venules in the gastric mucosa, these endothelial changes would be caused by the stress-induced overstimulation of the cholinergic nerves and modified by the degranulation of mast cells, contributing to the stress-induced ulcer formation as schematically illustrated in Fig. 10.
Oda
M
M
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
Nakamura
M
M
Honda
K
K
Komatsu
H
H
Kaneko
K
K
Azuma
T
T
Suematsu
M
M
Yonei
Y
Y
Watanabe
N
N
Tsuchiya
M
M
D000368:Aged; D000818:Animals; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply* / Q000294:innervation / Q000473:pathology; D006408:Hematoma, Subdural / Q000150:complications; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D008407:Mast Cells / Q000378:metabolism / Q000473:pathology; D008833:Microcirculation; D010438:Peptic Ulcer Hemorrhage / Q000209:etiology; D051381:Rats; D011950:Receptors, Cholinergic / Q000032:analysis; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000209:etiology* / Q000503:physiopathology; D013312:Stress, Physiological / Q000150:complications* / Q000503:physiopathology; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology
D011950:Receptors, Cholinergic