title: Realization of spontaneous healing function by carnosine.
abstract: Granulation is a tissue response with high potential of immunity and tissue repair. Carnosine was found to be a physiological stimulator that promotes granulation, and as carnosine and beta-alanine were shown to not only stimulate granulation but also accelerate wound healing, modulate immunoresponse, and non-specifically increase immunocompetence, therapeutic and prophylactic enhancement of spontaneous healing function of the body was suggested to be possible. In this report, revision of conventional medical concepts necessitated by recognition of homeostasis as a concrete manipulable entity, resolution of side effects of anti-tumor agents by homeostasis-stimulators, the possibility of direct treatment of cancer with homeostasis-stimulators, experimental reproduction of spontaneous regression, and a tripartite theory of carcinogenesis, including homeostasis as a key factor in the carcinogenic mechanism, are discussed as related to carnosine as a drug of the future.
authors.affiliation: Department of Pathophysiology, Dental Research Center, Nihon University, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nagai
authors.forename: T
authors.initials: T
authors.lastname: Suda
mesh_terms: D000818:Animals; D002336:Carnosine / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D006801:Humans; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D004151:Dipeptides; D002336:Carnosine