Comparative effect of captopril and nifedipine in normotensive patients with incipient diabetic nephropathy.
The effect of a six-week treatment by placebo, the calcium channel blocker nifedipine or the converting enzyme inhibitor captopril was assessed in normotensive patients with insulin-dependent diabetes and incipient nephropathy. In response to captopril and nifedipine, arterial pressure decreased slightly and to a similar extent. These drugs resulted in opposite effects on urinary albumin excretion (increase in urinary albumin excretion by 40% during nifedipine and decrease by 40% during captopril treatment). No change in urinary albumin excretion was observed in the placebo group. This observation of opposite changes in urinary albumin excretion in the presence of a similar fall in arterial pressure suggests that the effect of captopril and nifedipine on urinary albumin excretion results from some difference in their intrarenal action.
Insua
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Department of Medicine, Centre Hospitalier Universitaire, Montpellier, France.
Ribstein
J
J
Mimran
A
A
D000328:Adult; D000419:Albuminuria / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D009543:Nifedipine / Q000627:therapeutic use*; D011897:Random Allocation
D002216:Captopril; D009543:Nifedipine