Increase in vascular permeability of rat and guinea pig skin by T-kinin.
The vascular permeability-increasing response to T-kinin in rat and guinea pig skin was investigated. The vascular permeability was measured with 125I-labeled bovine serum albumin [( 125I]BSA) as a tracer. Plasma exudation rapidly occurred 0-15 min after the intradermal injection of T-kinin. T-kinin in doses of 0.3, 1, and 3 nM/spot significantly increased the vascular permeability in a dose-dependent manner. The vascular response of T-kinin is similar to that of bradykinin. On the other hand, T-kinin analogs, D-Ile-Ser-bradykinin and Ile-D-Ser-bradykinin only weakly enhanced the vascular permeability. Prostaglandin E1, forskolin, and the angiotensin-converting enzyme inhibitor, SQ-14225, potentiated the T-kinin-induced plasma exudation. Cyproheptadine and indomethacin did not affect the T-kinin-induced response. The results suggest that T-kinin will play an important role in increasing vascular permeability associated with inflammation.
Sugio
K
K
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta 30912.
Greenbaum
L M
LM
D000527:Alprostadil / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D002216:Captopril / Q000493:pharmacokinetics / Q000494:pharmacology; D005576:Colforsin / Q000493:pharmacokinetics / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005122:Exudates and Transudates / Q000187:drug effects; D006168:Guinea Pigs; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000098:blood supply* / Q000187:drug effects
D005576:Colforsin; C039065:T-kinin; D002216:Captopril; D000527:Alprostadil; D001920:Bradykinin