title: [Influence of the inoculum effect on minimal inhibitory concentrations of 3 derivatives of 5-nitro-imidazole and 11 other antibiotics on Bacteroides fragilis].
abstract: Three nitro-imidazole derivatives and eleven other antibiotics were studied for both their antimicrobial activity and the degree to which they produced inoculum effect on twenty strains of Bacteroides fragilis group. Five inocula were studied ranging from 10(5) to 10(9) CFU/ml. Statistical analysis show the significant influence of inoculum and those of strains. Nitro-imidazole derivatives exhibited a large inoculum effect while other antibiotics exhibited only a minimal to-no-inoculum effect.
authors.affiliation: Laboratoire de Bactériologie et Biologie cellulaire, Factulé de Pharmacie, Montpellier.
authors.forename: G
authors.initials: G
authors.lastname: Dusart
authors.forename: M
authors.initials: M
authors.lastname: Simeon de Buochberg
authors.forename: H
authors.initials: H
authors.lastname: Maillols
authors.forename: M
authors.initials: M
authors.lastname: Zuccarelli
authors.forename: M A
authors.initials: MA
authors.lastname: Attisso
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001441:Bacteroides fragilis / Q000187:drug effects*; D007769:Lactams; D008826:Microbial Sensitivity Tests / Q000379:methods*; D009593:Nitroimidazoles / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D007769:Lactams; D009593:Nitroimidazoles
vernacular_title: Influence de l'effet inoculum sur les concentrations minimales inhibitrices de trois dérivés du 5-nitro-imidazole et onze autres antibiotiques sur Bacteroides du groupe fragilis.