[Treatment of vasospasm in aneurysmal meningeal hemorrhage using intravenous nimodipine. Multicenter cooperative study].
We present a multicentric randomized double-blind study of the curative effect of intravenous Nimodipine on the post hemorrhagic vasospasm after aneurysmal rupture. On 122 validated cases out of 188 analyzed patients, the study demonstrates a significative effect on the mortality and severe morbidity related to vasospasm: the reduction of the risk is appreciated to 72%. The major effect is obtained on the mortality risk. A selective effect can be demonstrate on the isolated vasospasm.
Frerebeau
P
P
Service de Neurochirurgie B, Centre Gui-de-Chauliac, Montpellier.
Janny
P
P
Taquoi
G
G
Besson
G
G
Buchheit
F
F
Childs
M
M
Houtteville
J P
JP
Jan
M
M
Jomin
M
M
Pecker
J
J
D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D002532:Intracranial Aneurysm / Q000150:complications*; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009553:Nimodipine / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D012422:Rupture, Spontaneous; D013345:Subarachnoid Hemorrhage / Q000150:complications*
D009553:Nimodipine
Traitement curatif du vasospasme des hémorragies méningées d'origine anévrysmale par la nimodipine intraveineuse. Etude coopérative multicentrique.