title: Effects of low-level microwave irradiation on amphetamine hyperthermia are blockable by naloxone and classically conditionable.
abstract: In a series of experiments, we investigated the effects of pulsed low-level microwave irradiation on amphetamine-induced hyperthermia in the rat. Rats were irradiated in a 2,450-MHz cylindrical waveguide exposure system at 1 mW/cm2, 2 mus pulses, 500 pps, average SAR of 0.6 W/kg. Acute (45 min) exposure to microwaves attenuated amphetamine-induced hyperthermia. This effect was blocked by pretreatment of the animals with the narcotic antagonist naloxone. In another experiment, rats were subjected to ten daily sessions of microwave exposure (45 min/session). On day 11, amphetamine-induced hyperthermia was studied in the animals immediately after a session of either microwave or sham exposure. Similar to the acute effect, amphetamine-induced hyperthermia was attenuated in rats irradiated with microwaves (unconditioned effect). In the sham-irradiated animals we observed a potentiation of the amphetamine-induced hyperthermia, which was a conditioned effect of microwaves. Thus, the conditioned effect (potentiation) was opposite in direction to the unconditioned effect (attenuation). No tolerance developed to the unconditioned effect after subchronic exposure. Furthermore, both conditioned and unconditioned effects of microwaves on amphetamine-induced hyperthermia could be blocked by treatment with naloxone. These data suggest that microwave irradiation may activate endogenous opioids, which in turn alter the actions of psychoactive drugs, and the effect of microwaves on drug action can be classically conditioned.
authors.forename: H
authors.initials: H
authors.lastname: Lai
authors.forename: A
authors.initials: A
authors.lastname: Horita
authors.forename: C K
authors.initials: CK
authors.lastname: Chou
authors.forename: A W
authors.initials: AW
authors.lastname: Guy
mesh_terms: D000661:Amphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects / Q000528:radiation effects*; D003214:Conditioning, Classical / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D008872:Microwaves; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009270:Naloxone; D000661:Amphetamine