title: [Results of a phase II study with the new cytostatic drug carboplatin in combination with 5-fluorouracil in the primary treatment of advanced squamous cell cancers of the head and neck].
abstract: Chemotherapeutic regimens containing Cisplatin are the most effective in the treatment of squamous cell carcinoma of the head and neck. Because of the high rate of dose-limiting side effects of Cisplatin, Carboplatin, a second generation Cisplatin analog, was tested in a phase II trial with 5-FU on 55 previously untreated patients with advanced carcinoma of the head and neck. The results of the completed study are: 33% CR, 54% PR, 10% NR and 4% PD. Toxic side effects were tolerable myelotoxicity as with Cisplatin/5FU, mild nausea, vomiting and nephrotoxicity. No ototoxicity was seen. Most patients showed better performance status after chemotherapy with increased body weight. These results indicate that Carboplatin/5-FU is more effective and has milder side effects than Cisplatin/5-FU.
authors.affiliation: HNO-Universitätsklinik Köln.
authors.forename: P
authors.initials: P
authors.lastname: Volling
authors.forename: M
authors.initials: M
authors.lastname: Schröder
authors.forename: W
authors.initials: W
authors.lastname: Rauschning
authors.forename: W
authors.initials: W
authors.lastname: Achterrath
authors.forename: E
authors.initials: E
authors.lastname: Stennert
authors.forename: G
authors.initials: G
authors.lastname: Nagel
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D004341:Drug Evaluation; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage
chemical_list: D009944:Organoplatinum Compounds; D016190:Carboplatin; D005472:Fluorouracil
vernacular_title: Ergebnisse einer Phase II-Studie mit dem neuen Zytostatikum Carboplatin in Kombination mit 5-Fluorouracil zur primären Behandlung fortgeschrittener Plattenepithelkarzinome im Kopf-Halsbereich.