Circulatory responses to hypovolemia in the pregnant and nonpregnant sheep after pharmacologic sympathectomy.
Circulatory responses to progressive hypovolemia, hypotensive shock, blood reinfusion, and recovery were studied in pregnant and nonpregnant sheep with an intact or pharmacologically ablated sympathetic nervous system produced by administration of 6-hydroxydopamine. These studies also provided an opportunity to assess the contribution of the sympathetic nervous system to the maintenance of vasomotor tone in the pregnant animal at rest. The results show the following: (1) Although there were some differences in the circulatory adjustments to the initial period of blood loss between intact and "sympathectomized" animals, the overall circulatory responses to progressive hypovolemia, shock, blood reinfusion, and recovery were not significantly different in animals with intact or ablated sympathetic nervous systems whether or not they were pregnant. (2) The reasons for the similarity of cardiovascular responses to hypovolemia are the marked increase in catecholamine outputs by the adrenal medulla, which was not affected by 6-hydroxydopamine, and the supersensitivity of the systemic vascular beds of the sympathectomized animal to catecholamines. (3) The contribution of the sympathetic nervous system to the maintenance of the resting vasomotor tone is considerably enhanced during pregnancy, as demonstrated by the chronic effects of adrenergic ablation on the resting arterial pressure. (4) The circulation of the pregnant uterus possesses the ability of autoregulation during chronic changes of perfusing pressure as demonstrated by the differences in the arterial pressure and uteroplacental vascular resistance between intact and sympathectomized animals.
Tabsh
K
K
Rudelstorfer
R
R
Nuwayhid
B
B
Assali
N S
NS
D000313:Adrenal Medulla / Q000378:metabolism; D000818:Animals; D001775:Blood Circulation; D001794:Blood Pressure; D002395:Catecholamines / Q000378:metabolism; D005260:Female; D006339:Heart Rate; D006706:Homeostasis; D006892:Hydroxydopamines; D016627:Oxidopamine; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology*; D012039:Regional Blood Flow; D012769:Shock / Q000503:physiopathology*; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000502:physiology*; D013997:Time Factors; D014599:Uterus / Q000098:blood supply; D014655:Vascular Resistance; D014666:Vasomotor System / Q000502:physiology
D002395:Catecholamines; D006892:Hydroxydopamines; D016627:Oxidopamine