title: Amplification of the human putative oncogene INT1 in primary retinoblastoma tumors.
abstract: We report the amplification of the putative oncogene INT1 in two of four retinoblastomas. In one case, the INT1 signal was amplified 10 to 15-fold, in the other 100-fold. In both cases there were signs of increased tumor aggressiveness with invasion of the choroid and development of metastases. The two cases without INT1 amplification had neither metastases nor locally invasive growth. Our findings indicate that INT1 amplification may be a feature of increased malignant potential in retinoblastomas.
authors.affiliation: Department of Clinical Genetics, University Hospital, Lund, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Arheden
authors.forename: N
authors.initials: N
authors.lastname: Tommerup
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: J
authors.initials: J
authors.lastname: Winther
authors.forename: O A
authors.initials: OA
authors.lastname: Jensen
authors.forename: J U
authors.initials: JU
authors.lastname: Prause
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D015139:Blotting, Southern; D015342:DNA Probes; D005134:Eye Neoplasms / Q000235:genetics* / Q000473:pathology; D005784:Gene Amplification; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012175:Retinoblastoma / Q000235:genetics* / Q000473:pathology; D051153:Wnt Proteins; D029961:Zebrafish Proteins
chemical_list: D015342:DNA Probes; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins