Serum phosphate and 2,3-diphosphoglycerate in severely burned patients after phosphate supplementation.
Serum phosphate (S-P) and 2,3-diphosphoglycerate (2,3-DPG) were monitored for 10 days after severe burn trauma in 16 patients treated with total parenteral nutrition, including supplementation with 25-75 mmol phosphate daily. Phosphate metabolism was previously shown to be disturbed in patients with severe burns, and hypophosphatemia has been reported to disturb oxygen transport by reducing synthesis of 2,3-DPG in the red cells. In this study, S-P was decreased in the first post-trauma week because of a negative phosphate balance the first 4 post-trauma days, but 2,3-DPG remained at normal concentrations. These findings indicate that post-traumatic disturbance in red-cell phosphate metabolism may be prevented by administration of phosphate and that such supplementation is important in the metabolic management of severely injured patients.
Lovén
L
L
Larsson
L
L
Nordström
H
H
Lennquist
S
S
D019794:2,3-Diphosphoglycerate; D000293:Adolescent; D000328:Adult; D001784:Blood Gas Analysis; D001831:Body Temperature; D002056:Burns / Q000097:blood / Q000628:therapy*; D004163:Diphosphoglyceric Acids / Q000097:blood*; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D010710:Phosphates / Q000097:blood* / Q000378:metabolism / Q000627:therapeutic use / Q000652:urine
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D010710:Phosphates; D019794:2,3-Diphosphoglycerate