Effect of diazepam on sleep in patients with chronic airflow obstruction.
The effect of a single dose of diazepam on sleep and respiration was studied in nine patients with chronic airflow obstruction with moderate arterial hypoxaemia but no hypercapnia. Diazepam improved sleep duration without exacerbating nocturnal hypoxaemia and there was no change in the number of apnoeic events after a single 5 mg dose at night.
Wedzicha
J A
JA
Department of Thoracic Medicine, London Hospital.
Wallis
P J
PJ
Ingram
D A
DA
Empey
D W
DW
D000368:Aged; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000188:drug therapy*; D008297:Male; D010100:Oxygen / Q000097:blood; D012890:Sleep / Q000187:drug effects*; D014797:Vital Capacity / Q000187:drug effects
D003975:Diazepam; D010100:Oxygen