title: [In vitro activity of a combination of amoxicillin-clavulanic acid on anaerobic bacteria].
abstract: One hundred and one anaerobes isolated from clinical specimen were examined for their susceptibility to amoxicillin, alone or in combination with clavulanic acid, cefoxitin, cefotetan, cefotaxime, piperacillin and metronidazole. Tested strains were as follow: 90 Bacteroides fragilis group, 16 Bacteroides bivius and 5 Clostridium difficile. For 54 strains combination amoxicillin-sulbactam were also studied. Minimal inhibitory concentrations (MICs) were determined by agar dilution method on Wilkins-Chalgren agar. All the strains were susceptible to the combination amoxicillin-clavulanic acid. The mode MIC was 0.5 microgram/ml and 16 micrograms/ml for amoxicillin alone.
authors.affiliation: Laboratoire de Bactériologie, Centre Hospitalier d'Annecy.
authors.forename: A
authors.initials: A
authors.lastname: Sedallian
authors.forename: T
authors.initials: T
authors.lastname: Roudon
mesh_terms: D000658:Amoxicillin / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001439:Bacteroides / Q000187:drug effects; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000008:administration & dosage*; D003013:Clostridium / Q000187:drug effects; D004359:Drug Therapy, Combination / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D019818:Clavulanic Acid; D000658:Amoxicillin
vernacular_title: Activité in vitro de l'association amoxicilline-acide clavulanique sur les bactéries anaérobies.