Cerebral blood flow during chronic hypoglycemia in the rat.
Regional cerebral blood flow (rCBF) was measured in normoglycemic and chronically hypoglycemic rats. Chronic hypoglycemia was produced by continuously infusing insulin for 6-7 days. During chronic hypoglycemia (plasma glucose = 1.97 mumol/ml), rCBF increased in all regions except the cerebellum and hypothalamus. Blood flow increases present during chronic hypoglycemia were not as great as those previously measured during acute hypoglycemia. Therefore, adjustments in the regulation of rCBF occurred during chronic hypoglycemia compared to acute hypoglycemia.
Bryan
R M
RM
Department of Surgery (Neurosurgery), Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Pelligrino
D A
DA
D000818:Animals; D001783:Blood Flow Velocity; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D002908:Chronic Disease; D007003:Hypoglycemia / Q000139:chemically induced / Q000503:physiopathology*; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin