Primary hypoparathyroidism in the dog. Report of 15 cases and review of 13 previously reported cases.
Fifteen dogs with primary hypoparathyroidism diagnosed at the University of California Veterinary Medical Teaching Hospital were compared with 13 previously reported cases. Age, sex, breed, and historical and physical findings were similar in both groups of dogs. Middle-aged females were affected primarily. A history of neurologic or neuromuscular disease was present in all 28 dogs, with 18 dogs having seizures. Posterior lenticular cataract formation secondary to hypocalcemia was suspected in six dogs. The most characteristic biochemical finding in all dogs was profound hypocalcemia (less than 6.5 mg/dl) and mild hyperphosphatemia. Serum magnesium concentrations were decreased in two dogs. Serum parathyroid hormone concentrations were consistent with the diagnosis of primary hypoparathyroidism in eight of nine dogs. Lymphocytic parathyroiditis was diagnosed in the 12 dogs from which tissue was submitted for histopathology. Successful management of the patient depended on frequent monitoring of the serum calcium concentration during initial and maintenance therapy.
Bruyette
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Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis 95616.
Feldman
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EC
D000818:Animals; D002118:Calcium / Q000097:blood / Q000627:therapeutic use; D004097:Dihydrotachysterol / Q000627:therapeutic use; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy; D004285:Dogs; D004872:Ergocalciferols / Q000627:therapeutic use; D005260:Female; D006996:Hypocalcemia / Q000662:veterinary; D007011:Hypoparathyroidism / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D009468:Neuromuscular Diseases / Q000188:drug therapy / Q000662:veterinary; D010281:Parathyroid Hormone / Q000097:blood
D004872:Ergocalciferols; D010281:Parathyroid Hormone; D004097:Dihydrotachysterol; D002118:Calcium