title: Central nervous system decompression sickness: latency of 1070 human cases.
abstract: Many aspects of central nervous system (CNS) decompression sickness (DCS) are poorly understood, including the temporal pattern of its presentation and the pathogenic mechanisms involved in the development of the disease. Using case histories and clinical series published in the literature and retrieved from treatment center records, this study is an attempt to define the interval between surfacing from a hyperbaric exposure and the onset of symptoms of CNS DCS. The results of 1070 cases of human CNS DCS were included in the study. The results show that the disease generally occurs rapidly: over 50% became symptomatic within 10 min of returning to 1 ATA, and in only 15% of cases was the onset of symptoms delayed for more than 1 h. Cerebral DCS had a more rapid onset than spinal cord disease: 50% of cerebral cases became apparent within about 3 min and a similar proportion of spinal cord cases within about 9 min from surfacing. The influence of these results on the diagnosis and treatment of dysbaric illness, on the safety of certain diving practices, and on possible pathogenic mechanisms is discussed.
authors.affiliation: Diving Medicine Department, Naval Medical Research Institute, Bethesda, MD 20814-5055.
authors.forename: T J
authors.initials: TJ
authors.lastname: Francis
authors.forename: R R
authors.initials: RR
authors.lastname: Pearson
authors.forename: A G
authors.initials: AG
authors.lastname: Robertson
authors.forename: M
authors.initials: M
authors.lastname: Hodgson
authors.forename: A J
authors.initials: AJ
authors.lastname: Dutka
authors.forename: E T
authors.initials: ET
authors.lastname: Flynn
mesh_terms: D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000209:etiology*; D003665:Decompression Sickness / Q000145:classification / Q000175:diagnosis / Q000209:etiology*; D004242:Diving / Q000009:adverse effects; D006801:Humans; D012189:Retrospective Studies; D013997:Time Factors