title: Endotoxin protection against oxygen toxicity and its reversal by acetylsalicylic acid.
abstract: This study investigated the involvement of substances derived from arachidonic acid in the mechanism of endotoxin's protective action against pulmonary oxygen toxicity. Eighty-three percent of rats treated with a small dose of endotoxin (1 mg/kg) survived exposure to over 95% oxygen for 7 days. In contrast, all control rats exposed to the same oxygen concentration died within 3 days. When the endotoxin-treated rats were also treated with the soluble lysine salt of acetylsalicylic acid (100 mg/kg), 7-day survival decreased to 25%. This suggests that prostaglandin metabolism may play an important role in the protective action of endotoxin during hyperoxia.
authors.forename: J
authors.initials: J
authors.lastname: Klein
authors.forename: A
authors.initials: A
authors.lastname: Trouwborst
authors.forename: P J
authors.initials: PJ
authors.lastname: Salt
mesh_terms: D000818:Animals; D001241:Aspirin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004731:Endotoxins / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D010100:Oxygen / Q000506:poisoning*; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium
chemical_list: D004731:Endotoxins; D008239:Lysine; D001241:Aspirin; D010100:Oxygen; C010395:acetylsalicylic acid lysinate