title: [Cisplatin-based chemotherapy in the treatment of advanced-stage tumors of the bladder].
abstract: Since October 1984, 39 patients have been treated with cisplatin based chemotherapy for advanced bladder tumour of for pelvic recurrence or metastasis after total cystectomy. Cisplatin-methotrexate protocol (23 cases): 2 cases died during the first two cycles and 21 were evaluated after three cycles: only 39% of objective responses (2 CR-5 PR-2 MR) were observed with a mean survival not exceeding 12.6 months (7 deaths, 2 patients alive at the present time). All of the non-responders died within 4 to 16 months following the start of treatment (mean survival: 8.7 months). These particularly disappointing results led to the suspension of this protocol. Cisplatin-methotrexate-vinblastine protocol: 16 cases since September 1986. Eleven patients have been evaluated after three cycles: 3 CR-3 PR-5 PROG. The C.M.V. protocol appears to have a superior efficacy, principally on bladder, lymph node or lung lesions, at the cost of a higher but acceptable toxicity. Hepatic and central nervous system metastases were observed secondarily in this case.
authors.affiliation: Service d'Urologie, Hôpital Pellegrin, Bordeaux.
authors.forename: J M
authors.initials: JM
authors.lastname: Ferrière
authors.forename: T
authors.initials: T
authors.lastname: Piechaud
authors.forename: R
authors.initials: R
authors.lastname: Gaston
authors.forename: P
authors.initials: P
authors.lastname: Brucher
authors.forename: N
authors.initials: N
authors.lastname: Grenier
authors.forename: M
authors.initials: M
authors.lastname: Le Guillou
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage*; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012074:Remission Induction; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D014747:Vinblastine; D002945:Cisplatin; D008727:Methotrexate
vernacular_title: Chimiothérapie a base de cisplatine dans le traitement des tumeurs de vessie a un stade avancé.