Effect of insulin and 2-deoxy-D-glucose on feeding and plasma glucose levels in the spiny mouse.
Adult male spiny mice (Acomys cahirinus) were challenged with 2-deoxy-D-glucose (2-DG) or regular insulin, and food intake or plasma glucose concentration was measured. Mice did not increase their food intake over baseline levels following treatment with 2-DG (62.5-1000 mg/kg). In contrast, regular insulin injections (1-50 U/kg) stimulated a modest, but significant increase in feeding, which was apparent within 2 hr at a low dose of 1 U/kg. However, a marked hyper- and hypoglycemia (compared to saline controls), respectively, were induced within 30 min by 2-DG (250 and 500 mg/kg) and regular insulin (1 and 3 U/kg). Reduced glucose levels may not account for the insulin-induced hyperphagia.
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Department of Psychology, Marquette University, Milwaukee, WI 53233.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D009115:Muridae / Q000502:physiology*; D013045:Species Specificity
D001786:Blood Glucose; D003837:Deoxy Sugars; D007328:Insulin; D003847:Deoxyglucose