[Effect of isothiuronium alkylamidines and adeturon on the activity of lactate dehydrogenase and its isoenzymes in rat blood serum and organs].
A study was made of the effect of four types of S-omega-carboxamidinoalkyl isothiourea, differing in the carbon chain length between amidine and isothiuronium groups, and adeturon on activity of lactate dehydrogenase (LDG) and its isoenzymes in blood serum and organs of rats. Adeturon and compounds with one and three methylene groups elicit a radioprotective effect whereas substances with an even number of methylene groups have no such an effect. The obtained data indicate that changes in activity of LDG and its isoenzymes depend upon the structure of the substance applied. This makes LDG an adequate model in comparative studying the specificity of biochemical effects induced by the radioprotective agents and substances similar in their structure but having no radioprotective efficiency.
Tenchova
V B
VB
Pantev
T P
TP
Khadzhirusev
S B
SB
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D007527:Isoenzymes; D007550:Isothiuronium / Q000031:analogs & derivatives* / Q000494:pharmacology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D011833:Radiation Injuries, Experimental / Q000201:enzymology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013890:Thiourea / Q000031:analogs & derivatives*; D014018:Tissue Distribution; D000338:beta-Aminoethyl Isothiourea / Q000031:analogs & derivatives* / Q000494:pharmacology
D007527:Isoenzymes; D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D007550:Isothiuronium; C012704:Adeturon; D000255:Adenosine Triphosphate; D007770:L-Lactate Dehydrogenase; D013890:Thiourea
Vliianie izotiuronievykh alkilamidinov i adeturona na aktivnost' laktatdegidrogenazy i ee izofermentov v syvorotke krovi i organakh krys.