Rejection of cultured thyroid allografts by the transfer of sensitized LYT 2+ T cells.
Cultured BALB/c (H-2d) thyroid allografts, which are accepted permanently in fully immunocompetent allogeneic CBA/H (H-2k) recipients, are rejected following the transfer of immune spleen cells generated by immunization of recipient-strain mice with P815 (H-2d) which, like the cultured thyroid, expresses only class I major histocompatibility (MHC) antigens. Depletion of Lyt 2+ T cells from the transferred population abolished the capacity of immune spleen cells to trigger rejection, whereas depletion of L3T4+ T cells was without effect. Transfer of in-vitro-activated H-2d specific Lyt 2+ T cells also triggered rejection of cultured thyroid allografts. The results are consistent with previous studies showing that sensitized Lyt 2+ T cells are required for rejection of cultured pancreatic islet allografts, which also express only class I MHC antigens. These results are in accord with the notion that Lyt 2+ T cells are activated by and are active against class I MHC antigens.
Warren
H S
HS
Pembrey
R G
RG
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D000950:Antigens, Ly / Q000032:analysis; D000954:Antigens, Surface / Q000276:immunology; D006084:Graft Rejection; D051379:Mice; D008815:Mice, Inbred Strains; D009924:Organ Culture Techniques; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology* / Q000637:transplantation; D013961:Thyroid Gland / Q000276:immunology / Q000637:transplantation*
D000945:Antigens, Differentiation, T-Lymphocyte; D000950:Antigens, Ly; D000954:Antigens, Surface