Prevention of superficial phlebitis during peripheral parenteral nutrition.
Fifty-four patients receiving peripheral parenteral nutrition consisting of 3.5 percent amino acids in a 5 percent dextrose solution were randomly assigned in a double-blind fashion to receive this solution with or without an antiphlebitic mixture (1000 IU heparin, 5 mg hydrocortisone, and 1.8 mEq sodium hydroxide as a buffer). The addition of antiphlebitic mixture resulted in a marked and highly significant reduction in the incidence of phlebitis and a prolongation of the number of phlebitis-free hours during infusion of peripheral parenteral nutrition (p less than 0.005).
Makarewicz
P A
PA
Freeman
J B
JB
Fairfull-Smith
R
R
D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition / Q000009:adverse effects; D010689:Phlebitis / Q000517:prevention & control*; D011897:Random Allocation; D012972:Sodium Hydroxide / Q000008:administration & dosage; D013997:Time Factors
D000596:Amino Acids; D012972:Sodium Hydroxide; D006493:Heparin; D005947:Glucose; D006854:Hydrocortisone