Inhibition of radiogenic and chemically induced transformation in C3H/10T-1/2 cells by a polyprenoic acid (E-5166).
Using C3H/10T-1/2 mouse fibroblasts, we tested whether polyprenoic acid (E-5166) inhibits radiogenic and chemically induced transformation in vitro. Our results show that E-5166 markedly inhibits transformation by X rays and benzo[a]pyrene in a dose-related manner. Maximum inhibition was observed when cells were pretreated with E-5166 prior to carcinogen exposure, and lesser inhibition when E-5166 treatment followed carcinogen exposure. These results indicate that E-5166 can serve as a radio-protective and chemopreventive agent with anticarcinogenic potential.
Borek
C
C
Ong
A
A
Muto
Y
Y
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001564:Benzo(a)pyrene; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000528:radiation effects; D005347:Fibroblasts / Q000473:pathology; D051379:Mice; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000494:pharmacology
D000970:Antineoplastic Agents; D001564:Benzo(a)pyrene; D014212:Tretinoin; C034534:3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid