[The role of gastrin in regulating insulin and glucagon secretion in patients with diabetes mellitus].
The paper is concerned with the results of investigation of 26 donors and 85 patients with diabetes mellitus, type II, with normal body mass and obesity during GTT and a test breakfast to reveal correlation of IRI and IRG levels with the level of gastrin. Comparative analysis of indices during OGTT and food intake has shown that an increase in the levels of gastrin in patients with diabetes mellitus, type II, does not correlate with body mass and the total level of insulin, but it may correlate with a metabolically active form of insulin. During food intake the levels of gastrin rise and do not change during GTT. A rise of the level of gastrin in patients with diabetes mellitus, type II, during a test breakfast is accompanied by change in the level of insulin, its peak being lower than that during GTT. Attention was focused on a group of patients with a history of obesity in whom by the time of investigation body mass returned to normal and the level of glucose was decreased. However, gastrin and insulin levels were still high, and metabolic regulation was disturbed. Therefore, body mass normalization did not eliminate causative and pathogenetic factors of diabetes mellitus.
Starosel'tseva
L K
LK
Kniazeva
A P
AP
Belovalova
I M
IM
Abduraimova
G R
GR
D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000097:blood / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D005755:Gastrins / Q000097:blood / Q000502:physiology*; D005934:Glucagon / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007330:Insulin Antibodies / Q000032:analysis; D000078790:Insulin Secretion; D009765:Obesity
D001786:Blood Glucose; D002096:C-Peptide; D005755:Gastrins; D007328:Insulin; D007330:Insulin Antibodies; D005934:Glucagon
Rol' gastrina v reguliatsii sekretsii insulina i gliukagona u bol'nykh sakharnym diabetom.