title: The effect of omeprazole or ranitidine treatment on 24-hour esophageal acidity in patients with reflux esophagitis.
abstract: Twenty-two consecutive patients with gastroesophageal reflux and erosive or ulcerative esophagitis entered a double-blind, randomized study comparing the effect of 20 mg omeprazole once daily with that of 150 mg ranitidine twice daily on esophageal acidity. Ambulatory 24-h esophageal pH measurements were performed within 1 month before inclusion and after 3 weeks of medication. Omeprazole significantly (p less than 0.05) reduced the number of reflux (pH less than 4) episodes, the number of refluxes lasting greater than 5 min, and the total reflux time. In contrast, ranitidine significantly reduced only the total reflux time. When the two treatment groups were compared, a significant difference in favor of omeprazole was found for daytime and total reflux values, except for the longest reflux and the number of reflux episodes lasting greater than 5 min. Substantial differences, also in favor of omeprazole, were found with regard to the effect on endoscopic healing of the esophagitis.
authors.affiliation: Dept. of Otorhinolaryngology, Sahlgren's Hospital, University of Gothenburg, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Ruth
authors.forename: H
authors.initials: H
authors.lastname: Enbom
authors.forename: L
authors.initials: L
authors.lastname: Lundell
authors.forename: H
authors.initials: H
authors.lastname: Lönroth
authors.forename: N
authors.initials: N
authors.lastname: Sandberg
authors.forename: S
authors.initials: S
authors.lastname: Sandmark
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002940:Circadian Rhythm; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*; D011897:Random Allocation; D011899:Ranitidine / Q000627:therapeutic use*
chemical_list: D011899:Ranitidine; D009853:Omeprazole