title: The use of amide local anesthetics in patients susceptible to malignant hyperthermia.
abstract: The use of amide local anesthetics in dental patients presumed to be susceptible to malignant hyperthermia (MH) is controversial. A literature review of 17 recent dental publications and their reference citations revealed that the recommendation to avoid local anesthetics of the amide type in dental treatment of MH-susceptible (MHS) patients is based on in vitro muscle investigations, unpublished communications, and a single case report suggestive of MH. Therefore, a survey of members of the Malignant Hyperthermia Association of the United States designed to determine what, if any, MH-like reactions have occurred in patients with MHS receiving dental treatment was conducted. Of a total of 307 MHS respondents, 36 (12%) reported adverse reactions to dental care. Only one respondent, however, reported symptoms suspicious of MH (fever, muscle pain) in which the administration of amide local anesthetics appeared to be closely linked. Fifty-six (18%) of the respondents have had difficulty obtaining routine dental care since being identified as MHS; this includes 27 who have been refused dental treatment or have had to undergo operative procedures without the benefit of local anesthesia. These results support the conclusions that amide local anesthetics may be administered to MHS patients without significant risk and that currently the diagnosis of MH susceptibility can adversely affect the quality of dental care.
authors.affiliation: School of Dentistry, University of California, Los Angeles.
authors.forename: A
authors.initials: A
authors.lastname: Minasian
authors.forename: J A
authors.initials: JA
authors.lastname: Yagiela
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000577:Amides / Q000009:adverse effects*; D000766:Anesthesia, Dental / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003729:Dental Care; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D011795:Surveys and Questionnaires
chemical_list: D000577:Amides; D000779:Anesthetics, Local