title: Tetraploidy (92,XXYY) in an acute nonlymphocytic leukemia (M1) patient following autologous bone marrow transplantation.
abstract: Tetraploidy (4n = 92) without structural chromosome aberrations was found in bone marrow cells of a patient with acute nonlymphocytic leukemia, FAB classification M1, following autologous bone marrow transplantation. This finding, which remained undetected during the remission phases and appeared at relapses, progressed to a hypotetraploid modal number (74 chromosomes) at the terminal phase of the disease. Together with two previous observations in patients with acute lymphoblastic leukemia with L2 morphology and a null cell immunotype, this observation supports the hypothesis that tetraploid karyotypes may represent unusual and aspecific patterns of clonal evolution.
authors.affiliation: Division of Medical Genetics and Hematology, C. S. S. Hospital, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Zelante
authors.forename: G
authors.initials: G
authors.lastname: Perla
authors.forename: C
authors.initials: C
authors.lastname: Bodenizza
authors.forename: M M
authors.initials: MM
authors.lastname: Greco
authors.forename: M
authors.initials: M
authors.lastname: Carotenuto
authors.forename: B
authors.initials: B
authors.lastname: Dallapiccola
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000648:ultrastructure; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000628:therapy; D008297:Male; D011123:Polyploidy; D011379:Prognosis; D012008:Recurrence; D012074:Remission Induction; D014182:Transplantation, Autologous