Inducing effects of clofibric acid on 1-acylglycerophosphorylcholine acyltransferase in kidney and intestinal mucosa of rats.
Administration of p-chlorophenoxyisobutyric acid (clofibric acid) markedly increased the activity of microsomal 1-acylglycerophosphorylcholine (1-acyl-GPC) acyltransferase in kidney, intestinal mucosa and liver, but not in brain, heart, lung, spleen, testis or skeletal muscle. In both kidney and liver, a marked dose-dependent increase in the activities of both microsomal 1-acyl-GPC acyltransferase and peroxisomal beta-oxidation was observed. In the rats treated with clofibric acid at a relatively low dose, the increase in the activity of 1-acyl-GPC acyltransferase in kidney was more marked than that in liver. The extent of the relative increase in the activity of 1-acyl-GPC acyltransferase to the activity of peroxisomal beta-oxidation in kidney was more marked than that in liver. The increased activity of 1-acyl-GPC acyltransferase in both kidney and liver lasted throughout the 8-week treatment period of rat with clofibric acid.
Kawashima
Y
Y
Hirose
A
A
Hirose
Y
Y
Adachi
T
T
Kozuka
H
H
D008243:1-Acylglycerophosphocholine O-Acyltransferase; D000217:Acyltransferases / Q000096:biosynthesis*; D000818:Animals; D002994:Clofibrate / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D007413:Intestinal Mucosa / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D008099:Liver / Q000201:enzymology; D008297:Male; D008830:Microbodies / Q000201:enzymology; D008861:Microsomes / Q000201:enzymology; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D009928:Organ Specificity; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D009251:NADPH-Ferrihemoprotein Reductase; D000217:Acyltransferases; D008243:1-Acylglycerophosphocholine O-Acyltransferase; D002994:Clofibrate