title: 1-year treatment with recombinant somatropin in prepubertal and pubertal growth hormone deficient patients: results from a French multicentre trial.
abstract: In this French study with recombinant somatropin, the stimulation of growth in 32 prepubertal (age 10.0 +/- 3.5 years; mean +/- SD) and 19 pubertal (age 14 +/- 1.5 years) GH deficient children was compared; the stimulation of growth was similarly good in the two groups. The height velocity SD scores increased from -2.5 +/- 1.7 and -0.9 +/- 1.5 to 2.2 +/- 1.9 and 1.6 +/- 1.6 in prepubertal and pubertal children, respectively. Expressed as cm/year, these correspond to increases from 3.2 +/- 1.3 cm/year and 4.1 +/- 1.2 cm/year to 8.1 +/- 1.5 cm/year and 8.6 +/- 1.9 cm/year in the prepubertal and pubertal patients, respectively. Safety and tolerance were good and the immunogenicity of Genotonorm was low.
authors.affiliation: French Multicentre Trial Group, Paris, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Job
authors.forename: P
authors.initials: P
authors.lastname: Rochiccioli
authors.forename: R
authors.initials: R
authors.lastname: Rappaport
authors.forename: M C
authors.initials: MC
authors.lastname: Raux-Demay
authors.forename: C
authors.initials: C
authors.lastname: Ponte
authors.forename: J
authors.initials: J
authors.lastname: Juif
authors.forename: M
authors.initials: M
authors.lastname: Colle
authors.forename: M
authors.initials: M
authors.lastname: Lecornu
authors.forename: B
authors.initials: B
authors.lastname: Leheup
authors.forename: P
authors.initials: P
authors.lastname: Garandeau
mesh_terms: D000293:Adolescent; D000917:Antibody Formation; D001827:Body Height / Q000187:drug effects; D002648:Child; D005260:Female; D005602:France; D013006:Growth Hormone / Q000172:deficiency* / Q000276:immunology; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic; D011994:Recombinant Proteins
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone