Subcutaneous implantable infusion device for chronic intravenous pulsatile gonadotropin-releasing hormone treatment.
Preliminary data indicate the potential utility of an implantable subcutaneous device that facilitates chronic intravenous infusion of pulsatile gonadotropin-releasing hormone (GnRH) for ovulation induction. GnRH distribution curves were congruent in control monkeys and those with implanted devices. Tissue tolerance was good in this brief trial. These findings suggest that use of this or a similar implantable device be considered for chronic GnRH administration in human pulse therapy.
Schmutzler
R
R
Jones Institute for Reproductive Medicine, Department of OB/GYN, Eastern Virginia Medical School, Medical College of Hampton Roads, Norfolk.
van Uem
J F
JF
Elkind-Hirsch
K
K
Hahn
D
D
McGuire
J L
JL
Danforth
D R
DR
Hodgen
G D
GD
D000818:Animals; D005260:Female; D007260:Infusion Pumps; D007262:Infusions, Intravenous / Q000295:instrumentation*; D008253:Macaca mulatta; D010906:Pituitary Hormone-Releasing Hormones / Q000008:administration & dosage*
D010906:Pituitary Hormone-Releasing Hormones