Highly selective antiinflammatory and analgesic activity of 3-(1-methylethyl)-2-(4-methoxyphenyl)-3H-naphth[1,2-d]imidazole, a new non-acidic molecule.
3-(1-Methylethyl)-2-(4-methoxyphenyl)-3H-naphth[1,2-d] imidazole (MDL-035) has antiinflammatory activity in various antiinflammatory models such as carrageenin and nystatin oedemas, cotton pellet granuloma and adjuvant arthritis. The antiinflammatory potency of MDL-035 is greater than that of acetylsalicylic acid and phenylbutazone, but lower than that of indomethacin. MDL-035 has practically no gastroulcerogenic activity in rats, does not affect water or salt excretion, has no hormonal or antihormonal effects and has no other unwanted pharmacological effects. Its acute toxicity is very low.
Schiatti
P
P
Selva
D
D
Galliani
G
G
Baldoli
E
E
Diena
A
A
Glässer
A
A
Leali
M
M
Toja
E
E
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000633:toxicity; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors; D001169:Arthritis, Experimental / Q000473:pathology; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D006224:Cricetinae; D003967:Diarrhea / Q000517:prevention & control; D004285:Dogs; D004702:Endocrine Glands / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology* / Q000633:toxicity; D008112:Liver Glycogen / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D051379:Mice; D010060:Ovulation / Q000187:drug effects; D010437:Peptic Ulcer / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D014882:Water-Electrolyte Balance / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001095:Arachidonic Acids; D007093:Imidazoles; D008112:Liver Glycogen; D016718:Arachidonic Acid; D007986:Luteinizing Hormone; C043209:tomoxiprole