[Bacteremias after bone marrow grafts in a protected environment: effects, various aspects and prognosis].
We evaluated retrospectively the incidence and prognosis of bacteremias after bone marrow transplantation treated in protected environment with intestinal decontamination. Bacteremias are more frequent during the extreme granulopenia (55% of the patients) than during recovery of granulocyte counts greater than 500/mm3 (35% of the patients). Gram + organisms are more frequently responsible of bacteremias (80%), mainly Staphylococcus epidermidis and Streptococci. Mortality is low (7%) and related to additional factors like GVH, resistant leukemia. These data invite to develop new approaches of prevention of bacterial infection, with measures possibly efficient on Gram + organisms.
Michel
G
G
Unité de Transplantation Médullaire, INSERM U 119, Marseille, France.
Maraninchi
D
D
Blaise
D
D
Stoppa
A M
AM
Gastaut
J A
JA
Camerlo
J
J
Gaspard
M H
MH
Novakovitch
G
G
Carcassonne
Y
Y
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010356:Patient Isolation; D011183:Postoperative Complications; D011379:Prognosis; D018805:Sepsis / Q000453:epidemiology / Q000209:etiology*; D013203:Staphylococcal Infections / Q000209:etiology; D013212:Staphylococcus epidermidis; D013290:Streptococcal Infections / Q000209:etiology
Bactériémies après greffe de moelle en environnement protégé: incidence, aspects et pronostic.