Cortisol and immune interferon can interact in the modulation of human natural killer cell activity.
This paper reports that cortisol at physiological concentrations minimizes the enhancement of human natural killer (NK) cell activity in vitro by immune interferon (IFN-gamma). This effect may be important for the regulation of NK cytotoxicity in vivo.
Cavallo
R
R
Sartori
M L
ML
Gatti
G
G
Angeli
A
A
D000328:Adult; D003601:Cytotoxicity Tests, Immunologic; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D007371:Interferon-gamma / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008297:Male
D007371:Interferon-gamma; D006854:Hydrocortisone