Proximal muscle weakness and selenium deficiency associated with long term parenteral nutrition.
A 33-yr-old white female with short bowel syndrome secondary to trauma was maintained on home parenteral nutrition for 4 yr when her plasma, red cell, white cell, and platelet glutathione peroxidase (GSHPx) activities were found to be extremely low, as were her plasma and red cell selenium levels. During her first year on parenteral nutrition she noted the onset of an inability to rise from a squatting position, rapid tiring when stair climbing, and weakness when attempting to lift large or moderately heavy objects. Treatment with 400 micrograms/d of selenious acid intravenously was associated with a disappearance of her symptoms and an increase in proximal muscle strength within 6 wk. The plasma and red cell selenium levels, and the plasma and white cell GSHPx activities rose to normal levels within 6 wk. Red cell GSHPx activity returned to normal by 3 mo.
Brown
M R
MR
Cohen
H J
HJ
Lyons
J M
JM
Curtis
T W
TW
Thunberg
B
B
Cochran
W J
WJ
Klish
W J
WJ
D000328:Adult; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006801:Humans; D009133:Muscular Atrophy / Q000209:etiology; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D011770:Pyruvate Kinase / Q000378:metabolism; D020887:Selenious Acid; D012643:Selenium / Q000097:blood / Q000172:deficiency* / Q000627:therapeutic use*
D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D011770:Pyruvate Kinase; D020887:Selenious Acid; D012643:Selenium