title: Effect of oral glucose on the rate of metabolism of ethanol in humans.
abstract: We have tested whether the effect of carbohydrate on the rate of alcohol metabolism can be reproduced by glucose alone. Ten male subjects were given ethanol by intravenous infusion until a steady state was established and 100 g glucose in solution was then taken orally. The rate of alcohol metabolism, measured as the rate of infusion required to maintain a constant breath alcohol reading, increased significantly after glucose but there were differences between the subjects. The presence or absence of a change in the rate of alcohol metabolism after glucose was associated with the subject's fasting rate and with their glucose tolerance.
authors.affiliation: Department of Pharmacology, University of Sydney, NSW, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Mascord
authors.forename: J
authors.initials: J
authors.lastname: Smith
authors.forename: G A
authors.initials: GA
authors.lastname: Starmer
authors.forename: J B
authors.initials: JB
authors.lastname: Whitfield
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D000431:Ethanol / Q000097:blood / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006801:Humans; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D007328:Insulin; D000431:Ethanol; D005947:Glucose