Severe hypoglycemia as a short-term side-effect of the somatostatin analog SMS 201-995 in insulin-dependent diabetes mellitus.
We report on a case of severe hypoglycemia observed after injection of the somatostatin analog SMS 201-995 in an insulin-dependent diabetic patient connected to an artificial pancreas (Biostator GCIIS). Hypoglycemia occurred in a sudden and unexpected way 23 min after the first SMS injection (50 ug). Details on patient's characteristics and on the peculiar clinical situation in which this complication appeared are given. Furthermore, the possible mechanism(s) responsible for the hypoglycemia are thoroughly discussed. Finally we express a call for caution when administering this drug in insulin-dependent diabetes mellitus.
Navascuès
I
I
Servicio de Medicina Interna, Hospital Ramón y Cajal, Madrid, Spain.
Gil
J
J
Pascau
C
C
Senen
D
D
Serrano-Rios
M
M
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D003929:Diabetic Neuropathies / Q000097:blood / Q000188:drug therapy; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced*; D007328:Insulin / Q000097:blood; D007332:Insulin Infusion Systems; D015282:Octreotide / Q000009:adverse effects*
D001786:Blood Glucose; D007328:Insulin; D015282:Octreotide