title: Metabolic and hormonal response to acute cold exposure in newborn pig.
abstract: Glucose metabolism and changes in plasma insulin, glucagon and catecholamines were studied in unfed newborn pigs during acute cold exposure immediately after birth. When newborn pigs are exposed to a moderate cold external temperature (20 degrees C), they exhibit a transient thermoregulatory response characterized by an increased liver glycogenolysis, an enhanced blood glucose clearance rate (+35%) and a rise in plasma catecholamine concentrations. When the newborn pigs are exposed to a cold external temperature (12 degrees C), they become rapidly (10-12 h after birth) hypothermic and hyperglycaemic. This results from a fall in blood glucose clearance rate (-40%). Muscle glycogenolysis is low in normothermic animals during the 12 h following birth. Muscle glycogenolysis increases after a delay of 6 h in animals exposed to an external temperature of 20 degrees C or 12 degrees C. These data demonstrate that the failure in the thermoregulatory response in the newborn pig exposed to a cold temperature is not the consequence of a lack of mobilization of energy stores, but results from a defect in glucose utilization.
authors.affiliation: Centre de Recherches sur la Nutrition du CNRS, Meudon-Bellevue, France.
authors.forename: P H
authors.initials: PH
authors.lastname: Duée
authors.forename: J P
authors.initials: JP
authors.lastname: Pégorier
authors.forename: J
authors.initials: J
authors.lastname: Le Dividich
authors.forename: J
authors.initials: J
authors.lastname: Girard
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002395:Catecholamines / Q000097:blood; D003080:Cold Temperature; D005934:Glucagon / Q000097:blood; D006728:Hormones / Q000097:blood*; D007328:Insulin / Q000097:blood; D013552:Swine
chemical_list: D001786:Blood Glucose; D002395:Catecholamines; D006728:Hormones; D007328:Insulin; D005934:Glucagon