[Combined effects of radiation and 5-FU derivatives].
The combined effects of X-ray irradiation and 5-FU derivatives (5-FU, tegafur, HCFU) treatment were investigated in mouse adenocarcinoma-755. Mice were given a single irradiation 5 Gy or 10 Gy of 6-MV X-rays and orally administered 5-FU derivatives at the time of pre- or post-irradiation. Under these conditions, antitumor activity and survival time were compared between pre- and post-irradiation. Under these conditions, antitumor activity and survival time were compared between pre- and post-irradiation, in combination with 5-FU, tegafur or HCFU. The antitumor effects and survival time were greater for pre-irradiation treatment than for post-irradiation. Among 5-FU derivatives, the highest combination effect was shown by HCFU, followed by 5-FU and tegafur. The concentration of 5-FU in the tumor was correlated with the antitumor effect of each drug.
Miyamoto
H
H
Dokiya
T
T
Tominaga
J
J
Kunieda
E
E
Shigematsu
N
N
Hashimoto
S
S
D000230:Adenocarcinoma / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D005472:Fluorouracil / Q000031:analogs & derivatives / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D011879:Radiotherapy Dosage; D005641:Tegafur / Q000627:therapeutic use
D005641:Tegafur; C017367:carmofur; D005472:Fluorouracil