[Reproduction in monkeys of non-A, non-B hepatitis transmitted via the fecal and oral routes].
The paper presents the results of experimental infection of monkeys with virus-containing specimens from a patient with fecal-oral non-A-non-B hepatitis; the study was aimed at the determination of the possibilities of simulating this infection. Of the 8 monkeys infected with the material containing virus particles of fecal-oral non-A-non-B hepatitis 5 monkeys developed the infection manifested in virus excretion in fecal specimens, a rise in the level of serum aminotransferases, and typical histological lesions of the liver tissue. The infection could also be produced by inoculation of monkeys with virus-containing material from monkey. The above results indicate that the virus isolated from a human suffering from fecal-oral non-A-non-B hepatitis may induce in experimentally infected Macaca fascicularis monkeys a pathological process simulating viral hepatitis.
Andzhaparidze
A G
AG
Balaian
M S
MS
Savinov
A P
AP
Braginskiĭ
D M
DM
Poleshchuk
V F
VF
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001707:Biopsy, Needle; D002521:Cercopithecus; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D005243:Feces / Q000382:microbiology; D006506:Hepatitis A / Q000635:transmission; D006526:Hepatitis C / Q000382:microbiology / Q000473:pathology / Q000635:transmission*; D006518:Hepatitis Viruses / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000635:transmission*; D008099:Liver / Q000473:pathology; D008251:Macaca; D008252:Macaca fascicularis; D009055:Mouth / Q000382:microbiology; D013997:Time Factors
D000914:Antibodies, Viral
Vosproizvedenie na obez'ianakh gepatita ni A, ni B, peredaiushchegosia fekal'no-oral'nym putem.