Induction of rat gastric damage by the endothelium-derived peptide, endothelin.
The effect of the endogenous vasoconstrictor peptide, endothelin, on gastric mucosal integrity has been investigated in the rat. Local intra-arterial infusion of endothelin, in picomole doses, dose-dependently induced haemorrhagic and necrotic damage in the gastric mucosa. Such injury was not prevented by atropine, cimetidine, adrenoceptor antagonists, indomethacin, or the 5-lipoxygenase inhibitor BW A4C. These results suggest a potential pro-ulcerogenic role of endothelin in the pathogenesis of gastric damage and ulceration.
Whittle
B J
BJ
Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent.
Esplugues
J V
JV
D000818:Animals; D016232:Endothelins; D004730:Endothelium, Vascular / Q000502:physiology; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D008297:Male; D009336:Necrosis; D010455:Peptides / Q000494:pharmacology* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D016232:Endothelins; D010455:Peptides; D014662:Vasoconstrictor Agents