title: IgE responses of Wistar rats to Schistosoma mansoni infections.
abstract: Using the Wistar rat as experimental animal for Schistosoma mansoni infections it was shown that reaginic antibody response to S. mansoni antigens depends on the infection dose in a way that low infection doses induce persistent titres whereas high doses provoke transient titres. Repeated infections strongly favoured the reagins. In contrast, total serum IgE levels measured by ELISA followed a rather constant time course, independent from the mode of infection. Antigen-specific IgE antibodies followed none of the time courses and reached maximum levels about 12-15 weeks post infectionem. The data allow to suppose that different types of IgE occurred possessing different capacities to sensitize mast cells.
authors.forename: G
authors.initials: G
authors.lastname: Reiner
authors.forename: H
authors.initials: H
authors.lastname: Zahner
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D000947:Antigens, Helminth / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D007073:Immunoglobulin E / Q000096:biosynthesis*; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000276:immunology*; D013997:Time Factors
chemical_list: D000947:Antigens, Helminth; D007073:Immunoglobulin E