title: [Early postoperative thrombosis of an aortic Saint-Jude prosthesis. Success of fibrinolytic treatment].
abstract: We are reporting the case of a 63 year-old woman presenting an early thrombosis of a mechanical aortic Saint-Jude prosthesis, on the 21st post-operative day, following an insufficient anti-coagulant treatment and discovered by the presence of a well tolerated murmur of aortic insufficiency. The treatment consisted in fibrinolysis using urokinase, administered intravenously at a dose of 4,400 IU/kg/hour, for 12 hours. The clinical, ultrasound and radiocinematographic control performed on the 75th day, were normal; the patient, at that time being treated with anti-vitamin K and platelets anti-aggregates. No complication was observed. This case demonstrates the advantages of fibrinolytic treatments in early thrombosis following insertion of a valvular prosthesis.
authors.affiliation: Service de Cardiologie, Hôpital de la Salpêtrière, Paris.
authors.forename: D
authors.initials: D
authors.lastname: Sadoun
authors.forename: M
authors.initials: M
authors.lastname: Komajda
authors.forename: G
authors.initials: G
authors.lastname: Drobinski
authors.forename: D
authors.initials: D
authors.lastname: Thomas
authors.forename: A
authors.initials: A
authors.lastname: Vanetti
authors.forename: Y
authors.initials: Y
authors.lastname: Grosgogeat
mesh_terms: D001021:Aortic Valve; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D014568:Urokinase-Type Plasminogen Activator
vernacular_title: Thrombose post-opératoire précoce d'une prothèse de Saint-Jude en position aortique. Succès du traitement fibrinolytique.