title: EEG observations during combined haloperidol-lithium treatment.
abstract: Some reports have indicated a neurotoxic interaction of haloperidol and lithium, whereas others have not found this interaction. This is a report on two patients who showed both photomyoclonic and photoparoxysmal responses while on combined lithium-haloperidol treatment. We suggest that these findings, which have not been previously reported to be associated with combined lithium-haloperidol treatment, reflect neurotoxicity and that electroencephalogram (EEG) monitoring should be done on patients receiving this combined medication regimen.
authors.forename: R O
authors.initials: RO
authors.lastname: Addy
authors.forename: R H
authors.initials: RH
authors.lastname: Foliart
authors.forename: A S
authors.initials: AS
authors.lastname: Saran
authors.forename: D S
authors.initials: DS
authors.lastname: Schubert
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000139:chemically induced; D004828:Epilepsies, Partial / Q000139:chemically induced; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006220:Haloperidol / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D016651:Lithium Carbonate; D008297:Male; D010775:Photic Stimulation; D011618:Psychotic Disorders / Q000188:drug therapy*
chemical_list: D016651:Lithium Carbonate; D008094:Lithium; D006220:Haloperidol