Expression of the human immunoglobulin heavy chain gene of the 14q+ chromosome in a t(8;14)-positive Burkitt lymphoma cell line demonstrated in somatic cell hybrids.
A newly isolated Burkitt lymphoma cell line, ROS-1, carrying the specific translocation (8;14) has been studied using somatic cell hybridization techniques. As in other reported Burkitt cell lines, the oncogene c-myc was found to be translocated from the 8q- to the 14q+ chromosome. In contrast to other reports, expression of the mu immunoglobulin (Ig) heavy chain correlated with the presence of the 14q+ derivative and not of its normal homologue. These results indicate that the translocation (8;14) is not necessarily an abortive event for the production of the mu Ig heavy chain by the 14q+ derivative.
Versnel
M A
MA
van Dongen
J J
JJ
Geurts van Kessel
A H
AH
de Klein
A
A
Bos
N A
NA
Hagemeijer
A
A
D002051:Burkitt Lymphoma / Q000235:genetics*; D002460:Cell Line; D002901:Chromosomes, Human, 13-15; D002906:Chromosomes, Human, 6-12 and X; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D006822:Hybrid Cells; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D009857:Oncogenes; D014178:Translocation, Genetic
D004273:DNA, Neoplasm; D007143:Immunoglobulin Heavy Chains