Neutrophilic vascular reactions.
Dermatologic diseases are classified most commonly by morphology, by pathogenesis, or by etiology. Nontraditional classifications may be useful in terms of providing a reassessment of traditional views about disease interrelationships. This review of dermatoses characterized by neutrophilic infiltrates and dermal vessel changes reveals evidence suggesting that these dermatoses result from immune complex-mediated, neutrophil-induced dermal vessel damage. Therapeutic approaches to these heretofore unlinked dermatoses are remarkably similar.
Jorizzo
J L
JL
Department of Dermatology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27103.
Solomon
A R
AR
Zanolli
M D
MD
Leshin
B
B
D001528:Behcet Syndrome / Q000473:pathology; D006801:Humans; D007581:Jejunoileal Bypass / Q000009:adverse effects; D009504:Neutrophils / Q000473:pathology; D011711:Pyoderma / Q000473:pathology; D012867:Skin / Q000098:blood supply; D012871:Skin Diseases / Q000188:drug therapy / Q000473:pathology*; D014657:Vasculitis / Q000188:drug therapy / Q000473:pathology