Plasma paracetamol concentrations measured by fluorescence polarization immunoassay and gastric emptying time.
Radionuclide labeled gastric emptying was compared with plasma paracetamol (acetaminophen) concentration measured by fluorescence polarization immunoassay. A significant correlation was found between both gastric emptying half-time of radionuclide (t1/2) and % isotope remained in the region of the stomach and paracetamol absorption kinetic parameters. The strongest correlation was found between t1/2 and the time required to reach the peak plasma level of paracetamol (r = 0.680, p less than 0.01). This study indicates that simple paracetamol marker method has enabled an indirect quantitative measurement of gastric emptying by sampling at varying time intervals.
Koizumi
F
F
Department of Clinical and Laboratory Medicine, Tohoku University School of Medicine, Sendai.
Kawamura
T
T
Ishimori
A
A
Ebina
H
H
Satoh
M
M
D000082:Acetaminophen / Q000097:blood* / Q000493:pharmacokinetics; D004381:Duodenal Ulcer / Q000097:blood / Q000503:physiopathology; D005455:Fluorescent Antibody Technique; D005746:Gastric Emptying / Q000187:drug effects; D005756:Gastritis / Q000097:blood / Q000503:physiopathology; D006801:Humans; D007408:Intestinal Absorption; D013274:Stomach Neoplasms / Q000097:blood / Q000503:physiopathology; D013276:Stomach Ulcer / Q000097:blood / Q000503:physiopathology; D013997:Time Factors
D000082:Acetaminophen