Enhanced tumor metastases upon drug delivery in cross-linked albumin beads.
Growth of the murine hepatoma H6 was significantly suppressed by amiloride, a sodium influx inhibitor. Primary tumor growth inhibition was augmented by loading the drug into cross-linked albumin carriers, but lung metastases were enhanced. These results emphasize the importance of using metastatic tumor models when testing new drugs and/or alternative modes of drug delivery.
Moyer
M P
MP
Armstrong
A
A
Parra
J
J
Escobar
D
D
D000418:Albumins / Q000008:administration & dosage*; D000584:Amiloride / Q000008:administration & dosage*; D000818:Animals; D005976:Glutaral; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D051379:Mice; D009362:Neoplasm Metastasis
D000418:Albumins; D000584:Amiloride; D005976:Glutaral