Neonatal septicemia caused by coagulase-negative staphylococci.
We report our experience with coagulase-negative staphylococcal infection over a period of 1 year. The incidence of coagulase-negative staphylococcus septicemia was 4.25% (13 newborn infants) of the 306 admissions to our Neonatal Intensive Care Unit. Ten patients (76.9%) were premature infants. Four infants in our series were less than 48 h of age. Two of these were presumably born with the infection. Six infants had involvement of the lungs. The strains of coagulase-negative staphylococci cultured from all cases of neonatal septicemia were sensitive to cephalothin, but were considerably less sensitive to the currently used antibiotic combinations. Our observations indicate that coagulase-negative staphylococci must be suspected in early or late neonatal sepsis, and that early antibiotic treatment by cephalothin may prevent morbidity.
Sujov
P
P
Blazer
S
S
Bader
D
D
Zeltzer
M
M
D001805:Blood Transfusion, Intrauterine / Q000009:adverse effects; D002404:Catheterization; D002512:Cephalothin / Q000627:therapeutic use; D003030:Coagulase; D036861:Delivery, Obstetric; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008826:Microbial Sensitivity Tests; D010289:Parenteral Nutrition, Total; D011014:Pneumonia / Q000382:microbiology; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology
D003030:Coagulase; D002512:Cephalothin