Anti-Ly-1 antibody induces interleukin 2 release from T cells.
In this report we show that a signal provided by binding of anti-Ly-1 antibody to the Ly-1 cell surface protein, along with a second signal provided by mitogen, can trigger a T cell into activation and increase [Ca2+]i and the release of IL2. At optimal concentrations, the effects of anti-Ly-1 and IL 1 are additive, suggesting a different activation pathway for each.
Stanton
T
T
Stevens
T L
TL
Ledbetter
J A
JA
Wofsy
D
D
D000818:Animals; D000911:Antibodies, Monoclonal / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D002460:Cell Line; D007375:Interleukin-1 / Q000502:physiology; D007376:Interleukin-2 / Q000378:metabolism*; D007518:Isoantibodies / Q000502:physiology*; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D010835:Phytohemagglutinins / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000032:analysis; D015375:Receptors, Interleukin-2; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D007375:Interleukin-1; D007376:Interleukin-2; D007518:Isoantibodies; C029805:Lyt antibodies; D010835:Phytohemagglutinins; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D002118:Calcium