title: Preclinical and clinical results with an ultrasonic contrast agent.
abstract: In comparison to diagnostic radiology, ultrasound diagnostics has had no real contrast media. Theoretical considerations indicate that gas liquid systems seem to be favorable. The echocontrast agent SH U 454 is a system that releases minute gas bubbles that provide the contrast properties. Preclinical and clinical trials in more than 500 patients with right-heart lesions proved the efficacy and tolerance of the agent. Initial investigations showed that SH U 454 also may be useful in fields (eg, urology, gynecology) other than cardiology.
authors.affiliation: Institute for Contrast Media Research, Schering AG, West Berlin, West Germany.
authors.forename: T
authors.initials: T
authors.lastname: Fritzsch
authors.forename: M
authors.initials: M
authors.lastname: Schartl
authors.forename: J
authors.initials: J
authors.lastname: Siegert
mesh_terms: D000328:Adult; D003287:Contrast Media; D004341:Drug Evaluation; D005260:Female; D006330:Heart Defects, Congenital / Q000175:diagnosis; D006331:Heart Diseases / Q000175:diagnosis; D006801:Humans; D008297:Male; D011134:Polysaccharides; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D011134:Polysaccharides; C040642:SHU 454