Parenteral nourishment of patients undergoing surgical or traumatic stress.
Severe surgical or other traumatic stress initiates an integrated central nervous system and metabolic response characterized by catabolism which selectively preserves vital organs, drawing on peripheral tissue proteins for required amino acids. When oral intake is prohibited adequate intravenous nutritional support hastens convalescence and may be life-saving. Intravenous nutrients routinely consist of amino acids for replacement of lost protein, a nonprotein calorie source--usually glucose, and vitamins and minerals. Lipid, infrequently used in routine surgery as part of the calorie source, supplies essential fatty acids and prevents side effects resulting with large amounts of intravenous glucose. Lipid has other benefits. Stress-induced hormones stimulate lipid catabolism. When lipid is used for part of the calorie requirement in intravenous feedings, the plasma insulin level is reduced and peripheral amino acids become available for synthesis of critically needed visceral proteins. Recent work has shown that the branched chain amino acids carnitine and some species of lipid added to intravenous nutrient formulations postoperatively affect the nitrogen retention and may hasten convalescence. Further work should be directed at understanding the unique biochemical changes occurring after injury, devising objective assay procedures to measure the severity of the response and improving intravenous formulations for the acutely ill surgical patient.
Gilder
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D000596:Amino Acids / Q000627:therapeutic use; D002331:Carnitine / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D004734:Energy Metabolism; D005217:Fat Emulsions, Intravenous; D005227:Fatty Acids / Q000378:metabolism; D005526:Food, Formulated; D005934:Glucagon / Q000378:metabolism; D005938:Glucocorticoids / Q000378:metabolism; D005947:Glucose / Q000627:therapeutic use; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007659:Ketones / Q000378:metabolism; D008053:Lipid Mobilization; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D013312:Stress, Physiological / Q000378:metabolism / Q000628:therapy*; D013514:Surgical Procedures, Operative; D014947:Wounds and Injuries / Q000378:metabolism / Q000628:therapy*
D000596:Amino Acids; D002395:Catecholamines; D005217:Fat Emulsions, Intravenous; D005227:Fatty Acids; D005938:Glucocorticoids; D007328:Insulin; D007659:Ketones; D005934:Glucagon; D005947:Glucose; D002331:Carnitine