L-dopa reverses the effects of MPP+ toxicity.
The behavioral and neurochemical consequences of the intrastriatal administration of 1-methyl-4-phenylpyridinium ion (MPP+), the toxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were evaluated using the shuttlebox avoidance paradigm. MPP+ caused a significant depletion of striatal dopamine and significant disruption of shuttlebox performance. L-Dopa administration reversed both the dopamine depletion and the behavioral deficits. These observations are discussed in reference to the rodent-MPTP model of Parkinson's disease.
Wagner
G C
GC
Jarvis
M F
MF
Rubin
J G
JG
D015655:1-Methyl-4-phenylpyridinium; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D006540:Herbicides / Q000633:toxicity*; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011597:Psychomotor Performance / Q000187:drug effects; D011726:Pyridinium Compounds / Q000037:antagonists & inhibitors / Q000633:toxicity*
D006540:Herbicides; D011726:Pyridinium Compounds; D007980:Levodopa; D015655:1-Methyl-4-phenylpyridinium