Adriamycin and DT-diaphorase.
It has been suggested that DT-diaphorase (EC 1.6.99.2) can oppose the cytotoxic effect of the antineoplastic drug adriamycin. In this study, adriamycin was tested as a substrate for purified DT-diaphorase from rat liver. Purified DT-diaphorase was unable to use adriamycin as substrate. Also, the drug did not have any significant inhibitory effect on the enzyme.
Wallin
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D000818:Animals; D004317:Doxorubicin / Q000378:metabolism* / Q000494:pharmacology; D005290:Ferric Compounds / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology*; D008297:Male; D016660:NAD(P)H Dehydrogenase (Quinone); D011808:Quinone Reductases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013379:Substrate Specificity
D005290:Ferric Compounds; D004317:Doxorubicin; D016660:NAD(P)H Dehydrogenase (Quinone); D011808:Quinone Reductases