Hormonal modulation of cytosolic free calcium.
Many hormones are capable of increasing [Ca2+]i in many different tissues by mobilizing Ca2+ from internal stores, primarily the endoplasmic reticulum, and by promoting Ca2+ influx across the plasma membrane. Recent studies suggest that both processes involve G-proteins. In one case, a G-protein activates a PI 4,5-P2 specific phospholipase C, resulting in the formation of Ins 1,4,5-P3, which then releases Ca2+ from the endoplasmic reticulum. Ca2+ influx can be stimulated by low concentrations of agonist, which do not promote internal Ca2+ mobilization. This process appears to be stimulated directly by a G-protein.
Blackmore
P F
PF
Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism*; D006728:Hormones / Q000502:physiology*
D006728:Hormones; D002118:Calcium