Effect of interleukin-2 and mitogen on in vitro immunoglobulin production by peripheral blood lymphocytes from patients with selective IgM deficiency.
Immunoglobulin production by mitogen and recombinant interleukin-2-(rIL-2)-stimulated lymphocytes from IgM-deficient patients was studied. The findings were that subnormal serum IgM levels did not necessarily predict defective in vitro IgG or IgM production, lymphocytes from some IgM-deficient patients exhibited defective T cell function, and rIL-2 did not enhance defective in vitro immunoglobulin production.
Moffitt
J E
JE
Department of Pediatrics, Medical College of GA, Augusta 30912.
Guill
M F
MF
Wray
B B
BB
Brown
D A
DA
Peacocke
N W
NW
Ades
E W
EW
D000328:Adult; D002478:Cells, Cultured; D002675:Child, Preschool; D004406:Dysgammaglobulinemia / Q000097:blood*; D006801:Humans; D007075:Immunoglobulin M / Q000172:deficiency*; D007136:Immunoglobulins / Q000096:biosynthesis*; D007158:Immunologic Techniques; D007223:Infant; D007376:Interleukin-2 / Q000494:pharmacology*; D008214:Lymphocytes / Q000378:metabolism*; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology*
D007075:Immunoglobulin M; D007136:Immunoglobulins; D007376:Interleukin-2; D008934:Mitogens