Hereditary hydrocephalus in laboratory animals and humans.
Cerebral ventricle dilatation secondary to disturbed flow of CSF has been observed as an inheritable trait in a variety of laboratory animals as well as in humans. In few groups, however, has the neuropathology been adequately elucidated. In most cases, defective development of the cerebral aqueduct or of the subarachnoid space has been observed. Further study is needed to understand the developmental mechanisms that fail and give rise to hydrocephalus in such models.
Bruni
J E
JE
Department of Anatomy, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Del Bigio
M R
MR
Cardoso
E R
ER
Persaud
T V
TV
D000818:Animals; D002552:Cerebral Ventricles / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000502:physiology; D015170:Cerebrospinal Fluid Pressure; D006224:Cricetinae; D004108:Dilatation, Pathologic / Q000473:pathology; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D006849:Hydrocephalus / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D009154:Mutation; D051381:Rats