[Immunopathogeny of pemphigus].
This article reviews recent concepts of pathogenetic mechanisms in pemphigus. We describe the pathogenic effect of the autoantibodies, the animal model for the disease and the ultrastructural alterations which follow the antibody-antigen interaction. The role of complement and protease systems in development of tissue injury are also discussed.
Squiquera
L
L
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Anhalt
G J
GJ
Diaz
L A
LA
Sampaio
S A
SA
Rivitti
E A
EA
Martins
C R
CR
Cunha
P R
PR
Lombardi
C
C
Almeida
F A
FA
Martins Castro
A
A
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D010392:Pemphigus / Q000209:etiology* / Q000276:immunology
D001323:Autoantibodies
La inmunopatogenia de los pénfigos.