title: [Protection of the pulmonary toxic effects of normobaric oxygen by inducers of cytochrome P450-linked monooxygenases].
abstract: Inducers of cytochrome P450-linked mono-oxygenases increase the normobaric oxygen tolerance of the adult rat. Pulmonary inducers, as 3-methylcholanthrene and beta-naphthoflavone permit the rat survival and simultaneously a decrease of pulmonary edema. Phenobarbital, an hepatic inducer had lesser effects both on survival rate and on pulmonary and lymphoïd oxygen toxicity.
authors.forename: H
authors.initials: H
authors.lastname: Mansour
authors.forename: M
authors.initials: M
authors.lastname: Brun-Pascaud
authors.forename: M A
authors.initials: MA
authors.lastname: Gougerot-Pocidalo
authors.forename: J J
authors.initials: JJ
authors.lastname: Pocidalo
mesh_terms: D000818:Animals; D001571:Benzoflavones / Q000627:therapeutic use; D003577:Cytochrome P-450 Enzyme System; D004790:Enzyme Induction / Q000187:drug effects*; D008748:Methylcholanthrene / Q000627:therapeutic use; D010100:Oxygen / Q000037:antagonists & inhibitors* / Q000633:toxicity; D010105:Oxygenases / Q000096:biosynthesis*; D010634:Phenobarbital / Q000627:therapeutic use; D011654:Pulmonary Edema / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D019324:beta-Naphthoflavone
chemical_list: D001571:Benzoflavones; D008748:Methylcholanthrene; D019324:beta-Naphthoflavone; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D010100:Oxygen; D010634:Phenobarbital
vernacular_title: Protection des effets toxiques pulmonaires de l'oxygène normobare par les inducteurs enzymatiques des mono-oxygénases liés au cytochrome P450.