Vasoactive intestinal peptide and anterior pituitary function.
Vasoactive intestinal peptide (VIP) is a highly basic 28 amino-acid peptide which was first isolated from porcine small intestine (Said & Mutt, 1970). It is related to several other peptides including PHI (peptide with N-terminal histidine and C-terminal isoleucine amide), secretin, glucagon, and has some sequences similar to those of growth hormone releasing hormone (Fig. 1). The amino-acid sequence of human VIP is identical with that of the porcine form (Itoh et al., 1983). It has been shown that human VIP is cosynthesized with PHM (peptide with N-terminal histidine and C-terminal methionine amide, the human analogue of PHI) from the same large precursor protein (Itoh et al., 1983).
Prysor-Jones
R A
RA
Department of Medicine, St. George's Hospital Medical School, London, UK.
Jenkins
J S
JS
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D010903:Pituitary Gland, Anterior / Q000502:physiology*; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology / Q000502:physiology*
D014660:Vasoactive Intestinal Peptide; D011388:Prolactin