Alterations in motor behaviour produced by the isomers of 3-PPP in the MPTP-treated marmoset.
Alterations in motor activity induced by the isomers of 3-(3-hydroxyphenyl)-N,n-propylpiperidine (3-PPP) were studied in normal and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated marmosets. In both normal and MPTP-treated animals motor activity was suppressed in a dose-dependent manner by the administration of (-)-3-PPP. In control animals (+)-3-PPP caused biphasic changes in motor activity, namely suppression of activity in low doses but stimulation at higher doses. In contrast (-)-3-PPP only caused locomotor stimulation in MPTP-treated marmosets. (+)-3-PPP may potentially be of use as a post-synaptic dopamine agonist drug in Parkinson's disease.
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Jenner
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Marsden
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D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D002143:Callitrichinae; D005260:Female; D007536:Isomerism; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D011954:Receptors, Dopamine / Q000187:drug effects; D013997:Time Factors
D010880:Piperidines; D011725:Pyridines; D011954:Receptors, Dopamine; D007980:Levodopa; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; C026539:preclamol