Mammalian metallothionein is functional in yeast.
Expression of two monkey metallothioneins in yeast leads to complementation of both known functions of the endogenous yeast copperthionein gene, namely copper detoxification and autoregulation of transcription. The metallothionein-like proteins of higher and lower eukaryotes are therefore functionally analogous despite their dissimilar primary sequences.
Thiele
D J
DJ
Walling
M J
MJ
Hamer
D H
DH
D000818:Animals; D003300:Copper / Q000378:metabolism; D005786:Gene Expression Regulation; D005816:Genetic Complementation Test; D000882:Haplorhini; D008668:Metallothionein / Q000235:genetics / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D013045:Species Specificity; D013329:Structure-Activity Relationship; D014170:Transformation, Genetic
D003300:Copper; D008668:Metallothionein