title: Inhibition of bacterial colonization by antimicrobial agents incorporated into dental resins.
abstract: The antimicrobial activity of several chemical agents was determined by incorporating these agents into dentine adhesive resin and following the colonization of Streptococcus mutans on the surfaces of the resin and culture vessel, as well as in the surrounding medium, by optical density measurements. It was found that sodium fluoride and dodecylamine, an organic amine, exhibited excellent antimicrobial properties. These chemicals not only inhibited bacterial growth completely but also seemed to reduce the adhesion of the bacteria to the resin surface. A silver compound, protargin, was mildly effective in inhibiting growth of S. mutans. Copper oxide and chelating acids such as vanillic acid, syringic acid, and ethylenediamine-n, n' diacetic acid (EDDA) were not effective as antimicrobial agents against S. mutans.
authors.affiliation: University of Illinois College of Dentistry, Chicago 60612.
authors.forename: M S
authors.initials: MS
authors.lastname: Bapna
authors.forename: R
authors.initials: R
authors.lastname: Murphy
authors.forename: S
authors.initials: S
authors.lastname: Mukherjee
mesh_terms: D000588:Amines / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D003188:Composite Resins; D001840:Dental Bonding; D003738:Dental Cements; D005898:Glass; D019279:Resin Cements; D012969:Sodium Fluoride / Q000494:pharmacology; D013295:Streptococcus mutans / Q000187:drug effects*; D013499:Surface Properties
chemical_list: D000588:Amines; D000900:Anti-Bacterial Agents; D003188:Composite Resins; D003738:Dental Cements; D019279:Resin Cements; D012969:Sodium Fluoride; C041330:Scotchbond; C003935:dodecylamine