Modulation of ethanol-induced central nervous system depression by ibuprofen.
We investigated the effect of pretreatment with a prostaglandin synthetase inhibitor, ibuprofen, on the pharmacokinetics and pharmacodynamics of ethanol in six fasting subjects. Ibuprofen caused a 10% decrease in the maximum rate of elimination of ethanol. Visual memory, which is a function primarily mediated by the right cerebral hemisphere, was measured by the Benton Visual Retention test and was more impaired during combined ibuprofen and ethanol dosing than during ethanol dosing alone (P = 0.05). The auditory-verbal memory of the subjects, which is primarily a function of the left cerebral hemisphere, was assessed by the Selective Reminding Test and showed decreased impairment during combined ibuprofen and ethanol dosing as compared with ethanol dosing alone (P = 0.04). The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.
Minocha
A
A
Barth
J T
JT
Herold
D A
DA
Gideon
D A
DA
Spyker
D A
DA
D000328:Adult; D000818:Animals; D001519:Behavior / Q000187:drug effects; D001944:Breath Tests; D002490:Central Nervous System / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors; D003864:Depression, Chemical; D000431:Ethanol / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051379:Mice; D011597:Psychomotor Performance / Q000187:drug effects; D011897:Random Allocation
D016861:Cyclooxygenase Inhibitors; D000431:Ethanol; D007052:Ibuprofen