UV-mediated toxic bioactivity of harmine in the meristematic cells of Allium cepa.
The photodynamic effect of harmine and UV light was studied by measuring the number of sister-chromatid exchanges and micronuclei induced by this treatment in Allium cepa meristematic cells. A significant increase in the frequencies of both cytogenetic events was observed when proliferating cells were treated for 4 h with harmine followed by irradiation with UV light for 3 min.
Hazen
M J
MJ
Departmento de Biología, Unidad de Citología e Histología, Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.
Gutiérrez-Gonzálvez
M G
MG
D000470:Alkaloids / Q000494:pharmacology*; D000490:Allium / Q000187:drug effects / Q000235:genetics / Q000528:radiation effects*; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D006247:Harmine / Q000494:pharmacology*; D009152:Mutagenicity Tests; D012854:Sister Chromatid Exchange / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays
D000470:Alkaloids; D006247:Harmine