title: Zinc deficiency and lymphocyte subpopulations. A study by flow cytometry.
abstract: Zinc deficiency is well known to alter immunity. We report the case of a 18-yr-old female with relapsing Crohn's disease who experienced acrodermatitis enteropathica due to zinc deficiency during total parenteral nutrition (TPN). Blood lymphocytes have been studied by flow cytometry: before zinc treatment an important decrease of T-helper lymphocytes with high level of OKM-5+ lymphocytes had been observed. Zinc-supplemented diet induced within a few days, a rise of T-helper lymphocytes and a proportional reduction of OKM5+ cells. Increased values of high metabolism surface marker (OKT-9) were also observed, as well as cytoplasmic modifications. The authors suggest that lymphocyte surface markers could be useful to monitor TPN in patients at high risk for zinc deficiency.
authors.forename: Y
authors.initials: Y
authors.lastname: Couvreur
authors.forename: J P
authors.initials: JP
authors.lastname: Quarre
authors.forename: A
authors.initials: A
authors.lastname: Bailly
authors.forename: P
authors.initials: P
authors.lastname: Cornut
mesh_terms: D000169:Acrodermatitis / Q000209:etiology; D000293:Adolescent; D000911:Antibodies, Monoclonal; D003424:Crohn Disease / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008214:Lymphocytes / Q000145:classification* / Q000276:immunology; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D015032:Zinc / Q000172:deficiency*
chemical_list: D000911:Antibodies, Monoclonal; D015032:Zinc