title: A new case of chronic myelogenous leukemia with 14q+ marker and review of the literature.
abstract: We report a new case of Ph 1 positive chronic myelogenous leukemia (CML) with 14q+ marker shown during chronic phase (CP) and subsequently in blastic crisis (BC). After a review of the literature, we discuss the biological significance of 14q+ marker in developing lymphoid cellular differentiation, during evolution of CML, that remains still unclear. Besides, we also discuss the prognostic value of this change, concluding that a larger number of cases may clarify this question, as also the unresponsivity to chemotherapy of the patient studies so far, may not be related to 14q+ marker.
authors.affiliation: Institute of Biology and Genetics, University of Chieti, Italia.
authors.forename: G
authors.initials: G
authors.lastname: Palka
authors.forename: L
authors.initials: L
authors.lastname: Geraci
authors.forename: G
authors.initials: G
authors.lastname: Calabrese
authors.forename: L
authors.initials: L
authors.lastname: Stuppia
authors.forename: P
authors.initials: P
authors.lastname: Guanciali Franchi
authors.forename: G
authors.initials: G
authors.lastname: Parruti
authors.forename: D
authors.initials: D
authors.lastname: D'Antonio
authors.forename: G
authors.initials: G
authors.lastname: Fioritoni
mesh_terms: D000328:Adult; D002883:Chromosomes, Human, Pair 14; D005819:Genetic Markers; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D010677:Philadelphia Chromosome
chemical_list: D005819:Genetic Markers