Immunoelectron microscopic observation of prolactin (PRL) in human PRL secreting pituitary adenomas and non-neoplastic pituitary PRL cells.
Immunoelectron microscopic localization of prolactin (PRL) was studied in pituitary adenoma cells and in non-neoplastic PRL cells. The adenoma cells showed characteristic concentration of PRL in Golgi region which was ultrastructurally in Golgi saccules and in vesicular RER. In contrast, the non-neoplastic PRL cells showed lamellated RER which contained PRL. These results suggested disproportional production of PRL and its secretion in the adenoma cells.
Osamura
R Y
RY
Department of Pathology, Tokai University School of Medicine, Japan.
D000236:Adenoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D010902:Pituitary Gland / Q000473:pathology* / Q000648:ultrastructure; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D011388:Prolactin / Q000032:analysis* / Q000378:metabolism
D011388:Prolactin