H-Y antigens, testis differentiation, and spermatogenesis.
H-Y antigen defined by graft rejection and by cytotoxic T cell action ('transplantation H-Y') appears to be different from H-Y antigen that is characterized by antibodies ('serological H-Y'). Gene(s) for the transplantation H-Y were assigned to the long arm or to the centromeric region of the human Y chromosome. A regulatory gene for serological H-Y seems to be located in a distal region of the Y short arm. Various investigations suggest that serological H-Y has a molecular weight of approximately 18,000. While serological H-Y might be involved in the differentiation of the heterogametic gonad of vertebrates, transplantation H-Y may be required for normal spermatogenesis to occur in mammals.
Müller
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Division of Genetics, Children's Hospital, Boston, Mass.
Lattermann
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D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D006182:H-Y Antigen / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D012730:Sex Chromosomes; D013091:Spermatogenesis / Q000276:immunology*; D013737:Testis / Q000254:growth & development*; D014181:Transplantation Immunology
D006182:H-Y Antigen