[The expression and degradation of tissue thromboplastin].
The highest disintegration rate of FITC-thromboplastin occurred in the organs rich in RES-cells. The half-disintegration period was found to be 58 +/- 12 min in liver, 98 +/- 48 min in spleen, 262 +/- 36 min in kidneys, 310 +/- 114 min in lung microcirculatory flow. Several pathways were found of the thromboplastin tissue local disintegration mediated via proteolytic and lipolytic enzymes released from endothelial cells and leucocytes: endocytosis of RES-cells followed by intracellular cleavage by lysosomal enzymes; and gradual blood transfer of thromboplastin particles from the organs with moderate disintegration rate to the organs capable of rapid disintegration.
Zubairov
D M
DM
Popova
L G
LG
Evranova
G B
GB
Alkhanova
N A
NA
D000818:Animals; D001051:Apoenzymes / Q000378:metabolism; D002462:Cell Membrane / Q000201:enzymology; D004730:Endothelium, Vascular / Q000201:enzymology; D005260:Female; D006207:Half-Life; D008066:Lipolysis; D008297:Male; D012157:Mononuclear Phagocyte System / Q000201:enzymology; D010447:Peptide Hydrolases / Q000378:metabolism; D051381:Rats; D013925:Thromboplastin / Q000378:metabolism*; D014018:Tissue Distribution
D001051:Apoenzymes; C052493:F3 protein, human; D013925:Thromboplastin; D010447:Peptide Hydrolases
Ekspressiia i degradatsiia tkanevogo tromboplastina.