Involucrin expression in adnexal skin tumours. An immunohistological study.
The expression of involucrin was studied in a group of skin neoplasms, mostly of adnexal origin. As happens with other types of epithelial tumours, involucrin was detected in the most differentiated areas (presenting a squamoid or ductal differentiation). No reactivity was observed in non-epithelial skin tumours. These results suggest that involucrin is a specific marker for epithelial and adnexal differentiation of skin tumours and may thus be a useful aid in histopathologic diagnosis and classification of neoplasms.
Kanitakis
J
J
Zambruno
G
G
Viac
J
J
Thivolet
J
J
D002277:Carcinoma / Q000032:analysis / Q000473:pathology; D002454:Cell Differentiation; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D011498:Protein Precursors / Q000032:analysis*; D012189:Retrospective Studies; D012867:Skin / Q000032:analysis / Q000166:cytology; D012871:Skin Diseases / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000032:analysis* / Q000473:pathology
D011498:Protein Precursors; C032253:involucrin