Ciclosporin-associated hypertrichosis is not related to sex hormone levels following renal transplantation.
To study a possible relationship between ciclosporin-induced hypertrichosis and sex hormone pattern, the hair growth in different areas of the body was graded and hormone levels were assayed before and up to 6 months after kidney transplantation. Increased hair growth was observed in 100% (23/23) of the patients in skin areas connected with androgen action and in 78% of the patients in androgen-insensitive areas. After renal transplantation the pituitary, testicular and adrenal hormone levels normalized. The posttransplantation levels of these hormones would not explain the observation of increased hairgrowth. Thus, ciclosporin induces hypertrichosis via a mechanism independent of sex hormones.
Lindholm
A
A
Department of Transplantation Surgery, Karolinska Institute, Huddinge Hospital, Sweden.
Pousette
A
A
Carlström
K
K
Klintmalm
G
G
D000328:Adult; D000368:Aged; D003524:Cyclosporins / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D006983:Hypertrichosis / Q000097:blood / Q000139:chemically induced*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood
D003524:Cyclosporins; D012739:Gonadal Steroid Hormones; D011388:Prolactin