Formation of a diazoquinone-type mutagen from acetaminophen treated with nitrite under acidic conditions.
Acetaminophen (paracetamol) showed mutagenicity to Salmonella typhimurium TA100 and TA98 either with or without S9 mix when treated with excess nitrite in acidic solution. The mutagen was isolated and identified as 4-acetylamino-6-diazo-2,4-cyclohexadienone. Mutation tests and product analysis by high-performance liquid chromatography, however, suggested that this type of mutagen was hardly formed in the digestive tract of normal subjects.
Ohta
T
T
Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Oribe
H
H
Kameyama
T
T
Goto
Y
Y
Takitani
S
S
D000082:Acetaminophen / Q000378:metabolism* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D009153:Mutagens; D009573:Nitrites / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects
D009153:Mutagens; D009573:Nitrites; D000082:Acetaminophen