title: Absorption characteristic of breakfast determines insulin sensitivity and carbohydrate tolerance for lunch.
abstract: To test the hypothesis that prolonging absorption of breakfast might improve the glucose tolerance of the subsequent meal served at lunch, normal male volunteers were administered the same carbohydrate in either a rapidly absorbed (sucrose, S) or slowly absorbed (sucrose with guar, S + G) form for breakfast (0800) and lunch (1145). Area under the curve (AUC) for glucose did not differ for S at breakfast vs. S + G at breakfast, although AUCinsulin for S at breakfast was greater than that for S + G at breakfast (3389 +/- 608 vs. 1523 +/- 246 microU.min.ml-1, P less than .002). Plasma glucose and insulin profiles for the two breakfast meals differed markedly. Once S was ingested, plasma glucose and insulin returned to baseline after 120 and 160 min, respectively. However, once S + G was ingested, plasma glucose and insulin were still significantly above baseline values after 180 min. When S was eaten for breakfast, AUCglucose for lunch was similar to that for breakfast, regardless of whether lunch consisted of S or S + G. However, if S + G was eaten for breakfast, AUCglucose for S + G or S at lunch was 44% (P less than .005) and 75% of that for breakfast, respectively. Only one of five subjects who ingested S + G for breakfast failed to exhibit a fall in AUCglucose when S was eaten for lunch. The beneficial effect of prolonged absorption of breakfast on the glucose tolerance of lunch was not observed if the timing of lunch was delayed by 2 h (i.e., served at 1345).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298.
authors.forename: J E
authors.initials: JE
authors.lastname: Nestler
authors.forename: C O
authors.initials: CO
authors.lastname: Barlascini
authors.forename: J N
authors.initials: JN
authors.lastname: Clore
authors.forename: W G
authors.initials: WG
authors.lastname: Blackard
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D004435:Eating; D005685:Galactans; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D000078790:Insulin Secretion; D007408:Intestinal Absorption; D008297:Male; D008351:Mannans; D053149:Plant Gums; D012016:Reference Values; D013395:Sucrose
chemical_list: D001786:Blood Glucose; D005685:Galactans; D007328:Insulin; D008351:Mannans; D053149:Plant Gums; D013395:Sucrose; C007894:guar gum