Radiation sensitizing and radiation protective agents in experimental radiation therapy.
It appears that AB-132 potentiates radiation effects, and the local application of AET (MEG) protects the intestinal tract, the bladder and the skin against radiation toxicity. Combined use of selective radiation sensitizing and protecting agents may be considered for clinical studies.
Ambrus
J L
JL
Roswell Park Memorial Institute, Buffalo, NY 14263.
Halpern
J
J
Bardos
T
T
Chmielwicz
Z F
ZF
Klein
E
E
D000818:Animals; D001853:Bone Marrow / Q000473:pathology / Q000528:radiation effects; D016026:Bone Marrow Transplantation; D004307:Dose-Response Relationship, Radiation; D005622:Friend murine leukemia virus; D007422:Intestines / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D007942:Leukemia, Experimental / Q000532:radiotherapy*; D008251:Macaca; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D051381:Rats; D011916:Rats, Inbred F344; D012867:Skin / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D013552:Swine; D014916:Whole-Body Irradiation; D000338:beta-Aminoethyl Isothiourea / Q000627:therapeutic use*
D011838:Radiation-Sensitizing Agents; D000338:beta-Aminoethyl Isothiourea