title: Injection therapy for impotence.
abstract: Injection of vasoactive drugs is an effective form of treatment for selected patients with impotence from virtually all causes. The two most commonly employed drugs in the United States are either papaverine alone or various combinations of papaverine and phentolamine. Patients with organic and mixed impotence are best suited for injection treatment, but selected patients with psychogenic impotence also benefit from therapy. After the patient is selected for injection therapy, he undergoes a series of trial injections in the physician's office. The incidence of priapism will be minimized if the initially administered doses are low and the patient is titrated to an appropriate dose level. Uncontrolled trials have revealed that injection treatment produces a satisfactory erection in 65 to 100 per cent of patients for a follow-up period of as long as 2 years with minimal side effects, but the dropout rate is high. If priapism does occur, it almost always responds readily to treatment with aspiration, low doses of an alpha-adrenergic agent, or both. The other common side effects are bruising or ecchymosis and nodule formation at the injection site. This latter complication has not been noted to cause significant abnormal penile curavature necessitating cessation of the program.
authors.affiliation: Case Western Reserve University School of Medicine, Cleveland, Ohio.
authors.forename: E D
authors.initials: ED
authors.lastname: Kursh
authors.forename: D R
authors.initials: DR
authors.lastname: Bodner
authors.forename: M I
authors.initials: MI
authors.lastname: Resnick
authors.forename: S E
authors.initials: SE
authors.lastname: Althof
authors.forename: L
authors.initials: L
authors.lastname: Turner
authors.forename: C
authors.initials: C
authors.lastname: Risen
authors.forename: S B
authors.initials: SB
authors.lastname: Levine
mesh_terms: D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007267:Injections; D008297:Male; D010208:Papaverine / Q000008:administration & dosage* / Q000009:adverse effects; D010413:Penis / Q000098:blood supply; D010646:Phentolamine / Q000008:administration & dosage* / Q000009:adverse effects; D011317:Priapism / Q000139:chemically induced; D012039:Regional Blood Flow; D012646:Self Administration
chemical_list: D010208:Papaverine; D010646:Phentolamine