Blockade of amphetamine but not opiate-induced locomotion following antagonism of dopamine function in the rat.
The effects of pharmacological blockade of dopamine (DA) receptors or 6-OHDA lesions of mesolimbic DA fibers on the locomotor-activating properties of systemic amphetamine (0.35 mg/kg) and heroin (0.5 mg/kg) were examined. Pharmacological blockade of DA receptors or lesions of mesolimbic DA neurons blocked amphetamine but not heroin-induced locomotion. These results show that the opiate receptors essential for opiate-induced locomotor activation are not located on mesolimbic DA neurons. It appears that DA plays a primary role in stimulant-induced locomotion, but may have only a secondary role in opiate locomotion.
Vaccarino
F J
FJ
Amalric
M
M
Swerdlow
N R
NR
Koob
G F
GF
D000661:Amphetamine / Q000037:antagonists & inhibitors*; D000818:Animals; D018492:Dopamine Antagonists; D005475:Flupenthixol / Q000494:pharmacology; D003932:Heroin / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology; D008032:Limbic System / Q000378:metabolism; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains
D018492:Dopamine Antagonists; D006892:Hydroxydopamines; D009292:Narcotic Antagonists; D003932:Heroin; D016627:Oxidopamine; D000661:Amphetamine; D005475:Flupenthixol