Heart transplantation in repaired transposition of the great arteries.
Cardiac transplantation was carried out in a 40-year-old man with the diagnosis of repaired transposition of the great arteries and right-sided aortic arch who had end-stage cardiac failure due to myopathy of the ventricles. Because of several previous surgical repairs and the orientation of the great vessels, the operation presented some technical problems. Therefore, modifications of operative procedures were used, including recipient hypothermia, circulatory arrest, and changes in the donor heart implantation. The removal of the donor heart was modified in such a way that the graft included the aortic arch and both pulmonary arteries. With the extra length of ascending aorta and transverse arch, the innominate, left carotid, and left subclavian vessels were excised as a button, thereby leaving the distal orifice of the aorta in the superior portion of the transverse arch. For the recipient, the operation was performed using hypothermic total circulatory arrest to dissect free the huge pulmonary artery and the short right-sided aortic arch to place the clamp. Implantation of the donor heart was modified accordingly. The technical results were confirmed one and a half months later on a control digital angiogram. Thirty-five days postoperatively the patient was discharged. Six months after operation, the patient is doing better than ever before in his life. Our findings suggest that a complicated conotruncal development does not preclude cardiac transplantation.
Harjula
A L
AL
Department of Thoracic and Cardiovascular Surgery, Helsinki University Central Hospital, Finland.
Heikkilä
L J
LJ
Nieminen
M S
MS
Kupari
M
M
Keto
P
P
Mattila
S P
SP
D000328:Adult; D004374:Ductus Arteriosus, Patent / Q000601:surgery; D005500:Follow-Up Studies; D006343:Heart Septal Defects / Q000601:surgery; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008722:Methods; D011662:Pulmonary Subvalvular Stenosis / Q000601:surgery; D014188:Transposition of Great Vessels / Q000601:surgery*
D007166:Immunosuppressive Agents