title: Combined pharmacokinetic/pharmacodynamic (PK/PD) modeling.
abstract: Several compartmental and noncompartmental approaches have been successfully applied to PK/PD modeling. Although great opportunities exist to expand on these techniques, application of these methods to relate concentrations of all drugs to their effects is possible.
authors.affiliation: Pharmacokinetics/Drug Metabolism Department, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.
authors.forename: W A
authors.initials: WA
authors.lastname: Colburn
mesh_terms: D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D010600:Pharmacology