Influence of captopril on the arterial baroreceptor reflex in patients with heart failure.
In 16 male patients with heart failure (NYHA II-III), the influence of a single dose of 25 mg captopril on the carotid sinus baroreceptor reflex was examined. Blood pressure fell significantly by 11 +/- 1.7 mm Hg (P less than 0.001), whereas heart rate remained unchanged (85 +/- 3 vs. 83 +/- 3 beats min-1). Carotid sinus baroreceptors were stimulated by means of an airtight neck chamber. Two indices of baroreflex sensitivity were calculated. (1) The sensitivity to reflex heart rate slowing was increased by captopril from -2.9 +/- 0.7 to -5.0 +/- 1.3 ms mmHg-1 (P less than 0.02). The higher the initial sensitivity the more pronounced was the change after captopril with an increase of sensitivity by 46% (y = 1.46x -0.17, P less than 0.01). This increase in sensitivity cannot be explained by haemodynamic changes induced by captopril. (2) In eight patients the sensitivity of the baroreflex to increased transmural pressure gradients of the carotid sinus was evaluated by registration of the blood pressure response to neck suction; this demonstrated an unchanged responsiveness following captopril administration. From these data it can be concluded that captopril selectively augments a reflex bradycardia which is mediated by an increase in vagal efferent tone. The change in the reflex response depends on the initial reflex sensitivity and cannot be explained by haemodynamic changes caused by captopril.
Osterziel
K J
KJ
Department of Internal Medicine, (Cardiology), Ruprecht-Karls-University, Heidelberg, Federal Republic of Germany.
Röhrig
N
N
Dietz
R
R
Manthey
J
J
Hecht
J
J
Kübler
W
W
D000328:Adult; D000368:Aged; D001341:Autonomic Nervous System / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use*; D002346:Carotid Sinus / Q000294:innervation*; D006333:Heart Failure / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D011311:Pressoreceptors / Q000187:drug effects*; D012018:Reflex / Q000187:drug effects*; D012083:Renin / Q000097:blood; D014630:Vagus Nerve / Q000187:drug effects
D002216:Captopril; D012083:Renin; D009638:Norepinephrine