title: Intraarterial chemotherapy of head and neck tumors.
abstract: Forty-one patients with advanced recurrent or untreated and neck tumors were treated with intraarterial short-term (1-1 1/2 hr) infusion of cisplatin into the external carotid artery, achieving an immediate tumor response rate of 29.3%. Tumor extent within or beyond the territory of a single external carotid artery was the only significant factor identified affecting the tumor response rate (57.1% vs. 14.8%). Treatment with intraarterial chemotherapy using superselective catheterization before irradiation or surgery is beneficial in some patients.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Lee
authors.forename: S
authors.initials: S
authors.lastname: Wallace
authors.forename: I
authors.initials: I
authors.lastname: Dimery
authors.forename: H
authors.initials: H
authors.lastname: Goepfert
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000188:drug therapy; D008545:Melanoma / Q000188:drug therapy; D008875:Middle Aged; D012208:Rhabdomyosarcoma / Q000188:drug therapy
chemical_list: D002945:Cisplatin