The therapeutic value of vasodilator prostaglandins in multiple organ failure associated with sepsis.
There is considerable evidence from animal and human studies of sepsis and acute lung injury that prostacyclin and PGE1 may have a beneficial effect on tissue perfusion with a reduction in the severity of tissue damage associated with these disorders. As yet, there are no good data from controlled clinical trials that these agents improve survival and it is not clear whether in the future such data will be forthcoming. Nevertheless, using various physiological end-points, both prostaglandins seem to be beneficial in sepsis and when used in combination with the whole process of Intensive Therapy, may contribute to the survival of some cases. Although the assessment of combinations of agents designed to inhibit mediator release might be more useful, it remains to be seen whether the relatively insensitive controlled clinical trial, with survival as its endpoint, is the appropriate tool for assessing efficacy in the ITU. Perhaps, the 'consensus' approach has something to offer in this situation!
Bihari
D J
DJ
Department of Medicine, University College, London, UK.
Tinker
J
J
D003422:Critical Care; D011464:Epoprostenol / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009102:Multiple Organ Failure / Q000503:physiopathology*; D011458:Prostaglandins E / Q000494:pharmacology / Q000627:therapeutic use*; D012128:Respiratory Distress Syndrome / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D018805:Sepsis / Q000150:complications*; D012772:Shock, Septic / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D014947:Wounds and Injuries / Q000150:complications
D011458:Prostaglandins E; D011464:Epoprostenol