Potassium permeability in pancreatic beta-cell. The effect of thiopental.
We studied the effects of the barbiturate thiopental on mouse beta-cell membrane potential and electrical activity under conditions where K+ permeability was stimulated by increases in cytosolic Ca2+. Thiopental (1 mM) antagonized the hyperpolarizing effect of increases in cytosolic Ca2+, increased either by exposure of islets to 50 mM K+ or by reduction of cellular ATP content by 2,4 dinitrophenol.
Gonçalves
A A
AA
Departamento de Fisiologia e Biofísica, Universidade Estadual de Campinas, Brasil.
da-Silva
C A
CA
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D007515:Islets of Langerhans / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D011188:Potassium / Q000493:pharmacokinetics*; D013874:Thiopental / Q000494:pharmacology*
D013874:Thiopental; D011188:Potassium