Increased protective activity against acid precipitation of poly(U) in the serum of tumor-bearing mice.
Transplantation of leukemia L1210 cells into DBA/2 mice and of Ehrlich ascites tumor cells into BALB/C mice resulted in a significant increase of protective activity against acid precipitation of poly (U) in the serum. The increase was observed as early as one day after the tumor transplantation and seems to be connected with cancer growth, since inoculation of L1210 cells into BALB/C mice did not affect the protective activity, evidently as a result of their well established inability to cause cancer in this strain. Furthermore, no increase of activity was observed when bacteria were inoculated into mice, or when the latter were partially hepatectomized. The results suggest that the protective activity against acid precipitation of poly (U) could prove to be a tumor marker for the early detection of cancer growth.
Kouretas
D
D
Laboratory of Biochemistry, Theagenion Cancer Hospital, Thessaloniki, Greece.
Papageorgiou
A
A
Antonoglou
O
O
D000818:Animals; D001424:Bacterial Infections / Q000097:blood; D002286:Carcinoma, Ehrlich Tumor / Q000097:blood*; D004927:Escherichia coli Infections / Q000097:blood; D007939:Leukemia L1210 / Q000097:blood*; D008115:Liver Regeneration; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D008837:Micrococcus; D011072:Poly U / Q000097:blood* / Q000302:isolation & purification; D012016:Reference Values; D014238:Trichloroacetic Acid
D011072:Poly U; D014238:Trichloroacetic Acid