title: Hypoprothrombinemia due to cefamandole.
abstract: Two patients are described with severe coagulation disturbances, in one instance leading to extensive skin bleeding, secondary to the use of cefamandole. This cefalosporin antibiotic carries the same N-methylthiotetrazole side chain as moxalactam. Pathogenetic mechanisms leading to hypoprothrombinemia, its prevention and treatment are discussed.
authors.affiliation: Department of Intensive Care, University of Antwerp, University Hospital, Belgium.
authors.forename: V M
authors.initials: VM
authors.lastname: Conraads
authors.forename: H E
authors.initials: HE
authors.lastname: Demey
authors.forename: L G
authors.initials: LG
authors.lastname: Heytens
authors.forename: L L
authors.initials: LL
authors.lastname: Bossaert
mesh_terms: D000368:Aged; D000671:Amputation, Surgical; D002435:Cefamandole / Q000009:adverse effects* / Q000627:therapeutic use; D003925:Diabetic Angiopathies / Q000601:surgery; D005260:Female; D006474:Hemorrhagic Disorders / Q000139:chemically induced*; D006801:Humans; D007020:Hypoprothrombinemias / Q000139:chemically induced*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy; D011183:Postoperative Complications / Q000188:drug therapy
chemical_list: D002435:Cefamandole