Vasodilatory prostaglandins and cyclosporin nephrotoxicity.
Chronic nephrotoxicity would appear to be due to a combination of vasospasm and vascular pathology resulting in ischaemia from the narrowing and obliteration of some arterioles.
Neild
G H
GH
Dept. of Medicine, St Philip's Hospital, London, UK.
D000818:Animals; D003524:Cyclosporins / Q000633:toxicity*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced*; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats
D003524:Cyclosporins; D011453:Prostaglandins