The history of Nolvadex.
The research programme leading to the discovery of Nolvadex (tamoxifen, ICI 46474) (2; R1 = Me, X = Et), the anti-oestrogen used widely in the treatment of breast cancer, is described by the chemist involved in the discovery.
Richardson
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Imperial Chemical Industries PLC, Macclesfield, Cheshire.
D000818:Animals; D006801:Humans; D013629:Tamoxifen / Q000378:metabolism / Q000494:pharmacology
D013629:Tamoxifen