title: [Therapeutic use of human leukocyte interferon in dermatologic disorders caused by herpes simplex virus. Multicenter study].
abstract: A multi-institutional double blind study was performed in 66 patients in order to evaluate the action of human leukocyte interferon, type alpha (IFN) in lesions produced by herpes simplex virus. Lesions were localized in genital area in 34 cases and in facial area in 32 of them. From the total, 38 patients were treated with 7,000 Ul/gm. of interferon ointment and 28 with carbowax 4,000 as placebo. The symptoms pain, ardor, itching and paresthesia were evaluated asking to patients. Erythema, vesicles, crust, scale adenopathy were objectivated. Signs and symptoms were controlled on days 3 and 7 of treatment. In 42 patients, lesions specimens were taken for virus isolation. In 23 of them, cytopathic effect was detected (54.76%). Results showed a rapid relief from pain (p less than 0.05), ardor (p less than 0.01) and paresthesia (p less than 0.001) and also accelerated healing of vesicles in patients treated with interferon. Tendency to reduce the total time of the disease in those patients treated with IFN was observed.
authors.affiliation: Servicio de Dermatología del Hospital de Niños R. Gutiérrez, Buenos Aires, Argentina.
authors.forename: H
authors.initials: H
authors.lastname: Crespi
authors.forename: E
authors.initials: E
authors.lastname: de Mora
authors.forename: S
authors.initials: S
authors.lastname: Pueyo
authors.forename: L
authors.initials: L
authors.lastname: Jaimovich
authors.forename: S
authors.initials: S
authors.lastname: Stringa
authors.forename: E
authors.initials: E
authors.lastname: Raimondo
authors.forename: S
authors.initials: S
authors.lastname: Grinstein
authors.forename: M
authors.initials: M
authors.lastname: Criscuolo
authors.forename: C
authors.initials: C
authors.lastname: Davidovich
authors.forename: A
authors.initials: A
authors.lastname: Díaz
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D001118:Argentina; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006561:Herpes Simplex / Q000628:therapy*; D006801:Humans; D007223:Infant; D007370:Interferon Type I / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009824:Ointments
chemical_list: D007370:Interferon Type I; D009824:Ointments
vernacular_title: Uso terapéutico de interferón leucocitario humano en lesiones dermatológicas producidas por el virus del herpes simple. Estudio multicéntrico.