title: Neuroendocrinology of pyridoxine deficiency.
abstract: Dihydroxyphenylalanine decarboxylase and 5-hydroxytryptophan decarboxylase respectively have high and low affinities for pyridoxal phosphate. In the pyridoxine-deficient animal, hypothalamic serotonin content is significantly reduced without any change in catecholamine levels. Hypothalamic neurotransmitters affect the hypothalamo-pituitary-end organ axes. Specifically, the decrease in hypothalamic serotonin in the pyridoxine-deficient rat results in tertiary hypothyroidism. In addition, pineal function is affected in deficient animals due to decreased synthesis of melatonin.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Dakshinamurti
authors.forename: C S
authors.initials: CS
authors.lastname: Paulose
authors.forename: M
authors.initials: M
authors.lastname: Viswanathan
authors.forename: Y L
authors.initials: YL
authors.lastname: Siow
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000503:physiopathology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D026681:Vitamin B 6 Deficiency / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D012701:Serotonin