[Study of T lymphocyte subpopulations in patients with leprosy, using incubation with theophylline].
T cells and the theophylline resistant cells (the-r, helper cells) in peripheral blood of patients with different forms of leprosy were studied. Active lepromatous patients (LL+) showed a significant decrease in T lymphocytes and the-r cells. Nevertheless, in LL+ developing a reactional episode of erythema nodosum (LL-ENL) a restoration in the level of the-r cells was observed. It is concluded that in LL+ patients the depression of T cells and the-r cells represents an imbalance in the T-T cellular cooperation with a defective cellular immune response. On the other hand, the recovery of the-r cells in LL-ENL support the hypothesis of a cell mediated immune mechanism in the immunopathology of this reactional episode.
Bottasso
O
O
División Inmunología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Argentina.
Puig
N
N
Amerio
N
N
Morini
J C
JC
D006801:Humans; D007111:Immunity, Cellular; D007918:Leprosy / Q000276:immunology*; D008875:Middle Aged; D013601:T-Lymphocytes / Q000145:classification* / Q000503:physiopathology; D013806:Theophylline
D013806:Theophylline
Estudio de subpoblaciones de linfocitos T en pacientes con lepra, mediante la incubación con teofilina.