title: Historical aspects and applications of barbituric acid derivatives. A review.
abstract: This review considers the pharmacological and other applications of barbituric and 2-thiobarbituric acid derivatives. A chronological description about the discovery, structural studies and first clinical assays are given. Therapeutic expectations as anticonvulsant, antimicrobial, spasmolytic, antiinflammatory, antitumoral and some other effects of 5,5-disubstituted barbituric acids and alkylidene- or arylidenebarbituric acids are overviewed. A considerable amount of these types of compounds have been proposed as industrial dyes and pigments, photosensitizers and thermosensitive materials.
authors.affiliation: Department of Nutrition and Food Science, Faculty of Pharmacy, University of Sevilla, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Guillén Sans
authors.forename: M
authors.initials: M
authors.lastname: Guzmán Chozas
mesh_terms: D000818:Animals; D001463:Barbiturates / Q000266:history* / Q000494:pharmacology; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans
chemical_list: D001463:Barbiturates