The FGF-related oncogene, K-FGF, maps to human chromosome region 11q13, possibly near int-2.
The protein encoded in a novel human oncogene isolated by transfection of Kaposi's sarcoma DNA is a growth factor with significant homology to basic and acidic FGFs. The genomic structure of this oncogene (designated K-FGF), as originally isolated, carried DNA rearrangements upstream and downstream of the coding region. The normally discontinuous sequence upstream of the K-FGF coding region derived from the 3' end of the c-fms gene and thus originated from human chromosome 5. In order to determine the normal chromosomal location of the K-FGF gene and of the DNA sequences adjacent to its 3' end, we have correlated the presence of these sequences with retention of specific human chromosome regions in rodent-human somatic cell hybrids. These experiments mapped the K-FGF gene to human chromosome region 11q13----11q23, and in situ hybridization localized it more precisely to region 11q13 near int-2, which also belongs to the FGF family. The sequence downstream of the gene in transfectants and discontinuous with K-FGF in normal human DNA derives from chromosome region 12p12----12q13, possibly near the int-1 locus.
Huebner
K
K
Wistar Institute, Philadelphia, Pennsylvania 19104.
Ferrari
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Delli Bovi
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Croce
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Basilico
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D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D051518:Fibroblast Growth Factor 3; D005346:Fibroblast Growth Factors / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D005810:Multigene Family; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics; D012514:Sarcoma, Kaposi / Q000235:genetics*; D014162:Transfection
C496444:FGF3 protein, human; D051518:Fibroblast Growth Factor 3; D011518:Proto-Oncogene Proteins; D005346:Fibroblast Growth Factors