[Safety and sensitizing properties of a polyvalent corpuscular Pseudomonas aeruginosa vaccine and its effect on hematological indices].
The acute and chronic toxicity, influence on hematological characteristics and sensitizing properties of P. aeruginosa polyvalent corpuscular vaccine have been studied in experiments on 3 species of animals. The acute experiment has shown that the LD50 of the preparation contains not less than 7800 million cells, which is almost 160 times higher than the recommended immunizing dose (500 million cells). The safety of the preparation is confirmed by the data obtained in the histological and histochemical investigations of the tissues and organs of animals subjected to multiple immunizations with the vaccine. These investigations have revealed no pathological changes in the animals. During the study of the chronic toxicity of the preparation the hematological characteristics of the animals have been found to remain within normal limits. The vaccine has been shown to possess low sensitizing activity, which is manifested by the absence of severe reactions to allergic skin tests with different bacterial allergens (specific allergens obtained from P. aeruginosa and allergens obtained from other bacterial species), made on completion of the course of immunization with the vaccine.
Kharitonova
A M
AM
Grigor'eva
L V
LV
Antsiferova
N G
NG
Radkevich
S A
SA
Vetkova
L G
LG
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology / Q000633:toxicity*; D001769:Blood / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004306:Dose-Response Relationship, Immunologic; D007114:Immunization; D007928:Lethal Dose 50; D051379:Mice; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D001428:Bacterial Vaccines
Bezvrednost', sensibiliziruiushchie svoĭstva polivalentnoĭ korpuskuliarnoĭ sinegnoĭnoĭ vaktsiny i ee vliianie na gematologicheskie pokazateli.