title: Biological sample preparation and data reduction concepts in pharmaceutical analysis.
abstract: This paper describes strategies to rapidly develop sensitive and selective preparations using manual and robotic liquid-solid isolation (LSI) methods. LSI procedures offer selective isolation of drug or metabolites from complex matrices and are applicable to many pharmaceutical compounds. The beneficial effect of weighted linear regression is described, and several data reduction techniques are contrasted.
authors.affiliation: Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.
authors.forename: E L
authors.initials: EL
authors.lastname: Johnson
authors.forename: D L
authors.initials: DL
authors.lastname: Reynolds
authors.forename: D S
authors.initials: DS
authors.lastname: Wright
authors.forename: L A
authors.initials: LA
authors.lastname: Pachla
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D002845:Chromatography; D004364:Pharmaceutical Preparations / Q000032:analysis*
chemical_list: D004364:Pharmaceutical Preparations