title: Gamma knife: an alternative treatment for acoustic neurinomas.
abstract: Despite surgical advances and technologic means of better monitoring seventh and eighth nerve function intraoperatively, there remains a group of patients for whom alternative methods of treatment are desirable. These include the elderly, those with bilateral tumors or tumors in only hearing ears, individuals with medical contraindications to major surgery, and those who refuse surgical resection. The University of Pittsburgh became the fifth world center and the first in the United States to install the "gamma knife" for stereotactic radiosurgery. On the basis of the pioneering work done at the Karolinska Institute in Stockholm, acoustic tumor patients who fulfill the above criteria are being treated. A tumoricidal single treatment closed-skull radiation dose is given through 201 sharply focused cobalt 60 sources, minimizing the effects on surrounding brain or other tissues. Our early results are discussed and compared to those from more than 200 cases in Stockholm. Complications and expected long-term results are presented.
authors.affiliation: University of Pittsburgh School of Medicine, Pennsylvania.
authors.forename: D B
authors.initials: DB
authors.lastname: Kamerer
authors.forename: L D
authors.initials: LD
authors.lastname: Lunsford
authors.forename: M
authors.initials: M
authors.lastname: Møller
mesh_terms: D003037:Cobalt Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D005154:Facial Nerve / Q000528:radiation effects; D006309:Hearing / Q000528:radiation effects; D006801:Humans; D009464:Neuroma, Acoustic / Q000532:radiotherapy*; D013238:Stereotaxic Techniques
chemical_list: D003037:Cobalt Radioisotopes