Cellular basis of genetic nonresponsiveness to egg white lysozyme.
Utilizing radiation chimeras, we have investigated the cellular level at which the low immunological responsiveness to egg white lysozyme C57Bl/10 mice is expressed. Both NR----F1 (responder) and F1----NR combinations were assessed. The results demonstrate that C57Bl/10 bone marrow can give rise to hen egg white lysozyme responsive cells, but this response requires that the antigen be presented by cells derived from high responder animals.
Grimes
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S
Scibienski
R J
RJ
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D002645:Chickens; D002678:Chimera; D004529:Egg White; D005802:Genes, MHC Class II; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009113:Muramidase / Q000276:immunology*; D013154:Spleen / Q000166:cytology
D009113:Muramidase