title: In vitro secondary generation of cytotoxic T lymphocytes in mice with mumps virus and their mumps-specific cytotoxicity among paramyxoviruses.
abstract: Murine cells (L929, MC57G, and P815 mastocytoma) defectively infected with the egg-adapted vaccine strain of mumps virus were found to be susceptible to cytotoxic T-lymphocyte (CTL)-mediated lysis. In vitro secondary, but not in vivo primary, generated CTL caused cytolysis of these targets in an H-2-restricted manner. UV-inactivated-mumps virus-coated murine cells were also found to be susceptible to CTL-mediated lysis. Comparisons of murine CTL-mediated lysis by three paramyxoviruses (mumps, Sendai, and Newcastle disease viruses) indicated that no cross-reactivity occurred. The CTL response with mumps virus exhibited specific unresponsiveness patterns, as influenced by the H-2 K/D regions of the mouse strains, that were partially different from those of Sendai virus and Newcastle disease virus.
authors.forename: Y
authors.initials: Y
authors.lastname: Hosaka
authors.forename: Y
authors.initials: Y
authors.lastname: Yasuda
authors.forename: O
authors.initials: O
authors.lastname: Seriburi
authors.forename: M G
authors.initials: MG
authors.lastname: Moran
authors.forename: K
authors.initials: K
authors.lastname: Fukai
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D002478:Cells, Cultured; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D016650:Fluorescein-5-isothiocyanate; D005452:Fluoresceins; D006183:H-2 Antigens / Q000235:genetics; D007074:Immunoglobulin G / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009109:Mumps virus / Q000254:growth & development / Q000276:immunology* / Q000528:radiation effects; D010252:Paramyxoviridae / Q000276:immunology*; D011817:Rabbits; D013045:Species Specificity; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D013861:Thiocyanates; D014466:Ultraviolet Rays
chemical_list: D000914:Antibodies, Viral; D005452:Fluoresceins; D006183:H-2 Antigens; D007074:Immunoglobulin G; D013861:Thiocyanates; D016650:Fluorescein-5-isothiocyanate