Haemodynamic effectiveness of nimodipine on spastic brain vessels after subarachnoid haemorrhage evaluated by the transcranial Doppler method. A review of clinical studies.
The authors review the literature reports and own results of a double-blind study of the effectiveness of nimodipine on prevention or treatment of spasm of cerebral arteries following subarachnoid haemorrhage (SAH). Spasm has been evaluated using the transcranial Doppler method (TCD). The patients were divided into two groups which received 2 resp. 3 mg/h nimodipine. The clinical outcome and also the incidence of spasm of both of the groups were not different, but spasm was less severe in the 3 mg/h group.
Harders
A
A
Neurochirurgische Universitätsklinik, Freiburg i. Br., Federal Republic of Germany.
Gilsbach
J
J
D001783:Blood Flow Velocity / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D009553:Nimodipine / Q000627:therapeutic use*; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D013997:Time Factors; D014463:Ultrasonography
D009553:Nimodipine