Morphological studies of the neuromuscular mechanism shifting from sucking to biting of mice.
In order to give a neuroanatomical evidence to the mechanism of shifting from sucking to biting, we investigated in prenatal, newborn and postnatal mice whether there is a time difference in the neurogenesis of the neurons relative to sucking and biting or in the histogenesis of their peripheral effector organs by the HRP labeling technique and electron microscopy. The results obtained are as follows. (1) At birth the facial motoneurons exceed the trigeminal motoneurons in cell area and development. (2) After birth, the trigeminal motoneurons grow rapidly and outstrip the growth of the facial motoneurons at the age of 6 days. (3) Thereafter, the cell area of both neuron types continues to increase gradually. (4) The initial sign of the alpha motor end plates is found in the orbicularis oris muscle innervated by the facial nerve in 17-day-old fetuses, while that of the trigeminal nerve is delayed in the masseter muscle of 18-day-old fetuses. (5) The initial sign of the muscle spindle appears with the sensory terminals in the masseter muscle of 17-day-old fetuses and the fundamental structure of the muscle spindle is formed in 4-day-old youngs. (6) Myelination of the facial nerve begins in 3-day-old youngs, while that of the trigeminal nerve becomes apparent in 4- or 5-day-old youngs. From these bases, it is obvious that the facial nerve elements related to sucking are firstly developed at birth and that the differentiation of the trigeminal nerve elements related to biting is rapidly accelerated after birth.
Kubota
K
K
Institute of Stomatognathic Science, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
Narita
N
N
Ohkubo
K
K
Shibanai
S
S
Nagae
K
K
Kubota
M
M
Odagiri
N
N
Kawamoto
T
T
D000818:Animals; D001733:Bites and Stings / Q000503:physiopathology*; D007124:Immunoenzyme Techniques; D051379:Mice; D008813:Mice, Inbred ICR / Q000502:physiology*; D008854:Microscopy, Electron; D009132:Muscles / Q000166:cytology / Q000196:embryology / Q000648:ultrastructure; D009469:Neuromuscular Junction / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000196:embryology / Q000648:ultrastructure; D013391:Sucking Behavior / Q000502:physiology*; D013997:Time Factors