title: Acquired pachydermatoglyphy. A cutaneous sign of internal malignancy.
abstract: A 70-year-old man with hypertrophic osteoartropathy secondary to a squamous cell carcinoma of the lung presented a distinctive pattern of late-onset bilateral palmar keratoderma. A yellowish rugose appearance with accentuation of normal ridges and sulci (pachydermatoglyphy) involving the palms was observed. The differential diagnosis and the clinical relevance of acquired pachydermatoglyphy as a cutaneous marker of internal malignancy are discussed.
authors.affiliation: Department of Dermatology, Hospital Sant Pau, Barcelona, Spain.
authors.forename: R M
authors.initials: RM
authors.lastname: Pujol
authors.forename: L
authors.initials: L
authors.lastname: Puig
authors.forename: J M
authors.initials: JM
authors.lastname: García-Marques
authors.forename: J M
authors.initials: JM
authors.lastname: de Moragas
mesh_terms: D000052:Acanthosis Nigricans / Q000209:etiology; D000368:Aged; D001984:Bronchial Neoplasms / Q000150:complications*; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D003878:Dermatoglyphics; D003937:Diagnosis, Differential; D004604:Elephantiasis / Q000209:etiology*; D005260:Female; D006229:Hand Dermatoses / Q000209:etiology*; D006801:Humans; D008209:Lymphedema / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010004:Osteoarthropathy, Primary Hypertrophic / Q000175:diagnosis / Q000209:etiology