In vitro influence of charcoal on ciprofloxacin activity.
The effect of charcoal-containing media on ciprofloxacin (BAY o 9867) has been evaluated. The minimal inhibitory concentrations of ciprofloxacin are increased by the presence of charcoal, thus a correction factor has to be calculated to know the real efficacy of the drug, especially in life-threatening infections such as pneumonia due to Legionella spp.
Torre
D
D
Division of Infectious Diseases, General Hospital, Varese, Italy.
Sampietro
C
C
Quadrelli
C
C
Bianchi
W
W
Maggiolo
F
F
Ohnmeiss
H
H
D002606:Charcoal / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D004347:Drug Interactions; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
D002606:Charcoal; D002939:Ciprofloxacin