title: Immunoprophylaxis for influenza: comparison of a subunit and a whole virion vaccine.
abstract: In order to evaluate and compare immunogenicity, reactogenicity and protection of a subunit vaccine and a whole virus vaccine 102 elderly subjects were vaccined against influenza in November 1986: 53 received the subunit vaccine and 49 were immunized with the whole virus preparation. Local and systemic reactions following immunization, as well as the presence of influenza clinical symptoms were recorded throughout the study period (November 1986 - June 1987). Antibodies against influenza were detected using the Single Radial Haemolysis (S.R.H.) technique on two serum samples obtained from volunteers prior to immunization and 1 month later. The subunit vaccine showed equal immunogenicity, equal protection and lower reactogenicity as compared with the whole virus preparation.
authors.affiliation: Institute of Hygiene, University of Turin, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Carle
authors.forename: M
authors.initials: M
authors.lastname: Bolgiani
authors.forename: P
authors.initials: P
authors.lastname: Zanon
authors.forename: A
authors.initials: A
authors.lastname: Moiraghi Ruggenini
authors.forename: C
authors.initials: C
authors.lastname: Zotti
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000954:Antigens, Surface / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009975:Orthomyxoviridae / Q000276:immunology*; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D000954:Antigens, Surface; D000956:Antigens, Viral; D007252:Influenza Vaccines