Splanchnic glucose balance and insulin resistance in the early postoperative phase of cardiac surgery.
The splanchnic balance of glucose was studied in the basal state and at three levels of "clamped" hyperinsulinemia (260 +/- 23, 510 +/- 59, 3875 +/- 367 mU/liter) in 24 patients (43-70 years of age), who had undergone coronary surgery about 1 hr previously. The splanchnic balance of glucose in the basal state was negative in all patients (-1.6 +/- 0.3 mg/kg/min) and was changed into a zero-balance within 30 min when 0.15 or 0.3 U/kg/hr of insulin was infused. At an insulin infusion rate of 1.0 U/kg/hr the net splanchnic glucose balance was turned into a significant positive balance of an average 0.9 +/- 0.3 mg/kg/min.
Nilsson
F
F
Department of Thoracic and Cardiovascular Surgery, Sahlgrenska Hospital, Göteborg, Sweden.
Ekroth
R
R
Milocco
I
I
Nilsson
N J
NJ
Svensson
S
S
Berglin
E
E
William-Olsson
G
G
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance; D008297:Male; D008643:Mesentery / Q000378:metabolism*; D008875:Middle Aged; D011184:Postoperative Period
D001786:Blood Glucose; D007328:Insulin