Campylobacter pylori.
Worldwide Campylobacter pylori is a major cause of active chronic gastritis in man. This curved spiraled microorganism can readily be detected within the mucusgel especially in the antrum, in particular in patients suffering from peptic ulcer disease or non-ulcer dyspepsia, rarely in individuals with normal gastroduodenal mucosa. Increasingly arguments are being presented in support of a pathogenetic role of C. pylori in non-ulcer dyspepsia and in peptic ulcer disease. There is a striking discordance between in vitro antibiotic sensitivity, and in vivo efficacy with respect to suppression or eradication of the organism. At present the combination of colloidal bismuth subcitrate and amoxicilline or tinidazole appears to be encouraging with respect to longterm eradication of this peculiar microorganism. Eradication by antibacterial treatment ultimately may result in histologic normalization of the gastric mucosa. To what extent peptic ulcer disease. There is a striking discordance between in vitro antibiotic sensitivity, and in.
Tytgat
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Division Gastroenterology Hepatology, Academi Medical Centre, Amsterdam, The Netherlands.
Rauws
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EA
De Koster
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D002167:Campylobacter / Q000302:isolation & purification / Q000472:pathogenicity*; D002169:Campylobacter Infections; D004415:Dyspepsia / Q000209:etiology*; D005753:Gastric Mucosa / Q000276:immunology; D005756:Gastritis / Q000209:etiology*; D006801:Humans; D010437:Peptic Ulcer / Q000209:etiology*