title: Electron microscopic approaches to the study of bacterial DNA organization.
abstract: Electron microscopic techniques have been applied to the study of all aspects of structure, function and organization of prokaryotic and eukaryotic genomes. Today these powerful methods are mainly used in determining sequence relationships of large DNA molecules and in structural studies of nucleic acid-protein complexes. Some recent applications in the analysis of prokaryotic genomes are discussed.
authors.affiliation: Department of Microbiology, University of Basel, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Meyer
authors.forename: B
authors.initials: B
authors.lastname: Arnold-Schulz-Gahmen
mesh_terms: D002843:Chromatin / Q000648:ultrastructure; D004261:DNA Replication; D004269:DNA, Bacterial / Q000235:genetics / Q000648:ultrastructure*; D004279:DNA, Viral / Q000648:ultrastructure; D004268:DNA-Binding Proteins / Q000378:metabolism; D008854:Microscopy, Electron / Q000379:methods*; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D011485:Protein Binding; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D004269:DNA, Bacterial; D004279:DNA, Viral; D004268:DNA-Binding Proteins