Metabolic and hormonal response to acute cold exposure in newborn pig.
Glucose metabolism and changes in plasma insulin, glucagon and catecholamines were studied in unfed newborn pigs during acute cold exposure immediately after birth. When newborn pigs are exposed to a moderate cold external temperature (20 degrees C), they exhibit a transient thermoregulatory response characterized by an increased liver glycogenolysis, an enhanced blood glucose clearance rate (+35%) and a rise in plasma catecholamine concentrations. When the newborn pigs are exposed to a cold external temperature (12 degrees C), they become rapidly (10-12 h after birth) hypothermic and hyperglycaemic. This results from a fall in blood glucose clearance rate (-40%). Muscle glycogenolysis is low in normothermic animals during the 12 h following birth. Muscle glycogenolysis increases after a delay of 6 h in animals exposed to an external temperature of 20 degrees C or 12 degrees C. These data demonstrate that the failure in the thermoregulatory response in the newborn pig exposed to a cold temperature is not the consequence of a lack of mobilization of energy stores, but results from a defect in glucose utilization.
Duée
P H
PH
Centre de Recherches sur la Nutrition du CNRS, Meudon-Bellevue, France.
Pégorier
J P
JP
Le Dividich
J
J
Girard
J
J
D000222:Adaptation, Physiological; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002395:Catecholamines / Q000097:blood; D003080:Cold Temperature; D005934:Glucagon / Q000097:blood; D006728:Hormones / Q000097:blood*; D007328:Insulin / Q000097:blood; D013552:Swine
D001786:Blood Glucose; D002395:Catecholamines; D006728:Hormones; D007328:Insulin; D005934:Glucagon