title: Effect of carbamazepine on mean urinary free cortisol excretion in patients with major affective illness.
abstract: Carbamazepine, a tricyclic anticonvulsant effective in the treatment of major affective disorder, has been observed to induce cortisol non-suppression following dexamethasone administration. The mechanism of this effect has not been clearly established. In this study, the authors report carbamazepine-induced elevations of mean urinary free cortisol in patients with affective illness. The theoretical and practical implications of these findings are discussed.
authors.forename: D R
authors.initials: DR
authors.lastname: Rubinow
authors.forename: R M
authors.initials: RM
authors.lastname: Post
authors.forename: P W
authors.initials: PW
authors.lastname: Gold
authors.forename: T W
authors.initials: TW
authors.lastname: Uhde
mesh_terms: D002220:Carbamazepine / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine*; D019964:Mood Disorders / Q000652:urine*; D011863:Radioimmunoassay; D013997:Time Factors
chemical_list: D002220:Carbamazepine; D006854:Hydrocortisone