title: Results of genotoxicity testing of mazindol (degonan), lithium carbonicum (contemnol) and dropropizine (ditustat) in Chinese hamster V79 and human EUE cells.
abstract: We studied inhibition of DNA synthesis, alkaline elution of DNA, cytotoxicity and occurrence of induced 6-thioguanine resistant mutants in mammalian cells, treated with mazindol, lithium carbonicum, and dropropizine, respectively, in the presence and in the absence of microsomal fraction S9. Among the above-mentioned clinically used drugs only dropropizine showed neither mutagenic nor clastogenic effects. Lithium carbonicum manifested a weak and mazindol a medium genotoxic response which was in both cases reduced in the presence of microsomal fraction S9.
authors.forename: D
authors.initials: D
authors.lastname: Slamenová
authors.forename: E
authors.initials: E
authors.lastname: Budayová
authors.forename: A
authors.initials: A
authors.lastname: Gábelová
authors.forename: A
authors.initials: A
authors.lastname: Morávková
authors.forename: L
authors.initials: L
authors.lastname: Pániková
mesh_terms: D000818:Animals; D001564:Benzo(a)pyrene / Q000378:metabolism / Q000494:pharmacology; D001711:Biotransformation; D002460:Cell Line; D006224:Cricetinae; D004261:DNA Replication / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects*; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D008094:Lithium / Q000378:metabolism / Q000494:pharmacology*; D016651:Lithium Carbonate; D008168:Lung; D008297:Male; D008454:Mazindol / Q000378:metabolism / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D011409:Propylene Glycols / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D007211:Indoles; D011409:Propylene Glycols; D016651:Lithium Carbonate; D001564:Benzo(a)pyrene; D008094:Lithium; D008454:Mazindol; C035916:dipropizine