title: A common antidonor reactive serological pattern in patients with failed kidney regrafts.
abstract: Twenty retransplant patients were serially screened for donor-reactive antibodies (DRA). DRA appeared exclusively in patients whose grafts permanently failed and these DRA shared some common features, namely early appearance (days 4-8 post-transplant), high titers (1:10 up to more than 1:400), and broad anti-HLA specificity. This preliminary data would suggest that regrafted patients with primary graft failure represent a distinct subgroup of particularly immune responsive individuals.
authors.affiliation: Abteilung Experimentelle Organtransplantation, Bereich Medizin Charité, Humboldt-Universität, Berlin, German Democratic Republic.
authors.forename: J
authors.initials: J
authors.lastname: Groth
authors.forename: M
authors.initials: M
authors.lastname: Bursche
authors.forename: S
authors.initials: S
authors.lastname: Leverenz
authors.forename: J
authors.initials: J
authors.lastname: Kaden
authors.forename: D
authors.initials: D
authors.lastname: Scholz
mesh_terms: D000918:Antibody Specificity; D006084:Graft Rejection; D006680:HLA Antigens; D006801:Humans; D007518:Isoantibodies / Q000096:biosynthesis*; D016030:Kidney Transplantation; D012086:Reoperation; D013997:Time Factors
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies