title: Interaction of blood platelets with the vessel wall.
abstract: This review summarizes current insights in the importance of endothelium in the interaction of platelets with the subendothelium. A greater part of the results described are obtained with the use of cultured vessel wall cells. The following subjects are discussed: (1) the pro- and antithrombotic properties of the endothelial cells; (2) the synthesis of subendothelium by the endothelial cells and the influence of the composition of the subendothelium on its reactivity towards blood platelets; (3) the effect of (purified) matrix and plasma proteins on the adhesion process, and (4) various abnormalities of platelet adhesion are discussed that lead to enhanced bleeding tendency or to increased thrombus formation.
authors.affiliation: Department of Hematology, University Hospital, Utrecht, The Netherlands.
authors.forename: P F
authors.initials: PF
authors.lastname: Nievelstein
authors.forename: P G
authors.initials: PG
authors.lastname: de Groot
mesh_terms: D000818:Animals; D001778:Blood Coagulation Disorders / Q000097:blood; D001791:Blood Platelet Disorders / Q000097:blood; D003094:Collagen / Q000378:metabolism; D003095:Collagen Diseases / Q000097:blood; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D010974:Platelet Aggregation; D014842:von Willebrand Diseases / Q000097:blood; D014841:von Willebrand Factor / Q000502:physiology
chemical_list: D014841:von Willebrand Factor; D003094:Collagen