title: Roles of cell junctions in gametogenesis and in early embryonic development.
abstract: Recent reviews of the role of cell junctions in development have focused primarily upon functions related to the relatively subtle physiological modulation of their subunits in relation to fundamental developmental processes in a wide variety of organisms. There is, however, considerable support from numerous laboratories that the more radical modulation of the presence and number of junctional subunits in many diverse tissues may play a pivotal role in a wide spectrum of developmental phenomena ranging from gametogenesis to organogenesis. Since a great deal of recent interest in this latter subject has concentrated upon vertebrate systems including mammals, this review will examine the functional significance of the modulation of gap junctions, tight junctions and desmosomes in a developing idealized mammalian system from gamete formation to tissue and organ differentiation during embryo-genesis.
authors.affiliation: Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Ohio 45267-0521.
authors.forename: W J
authors.initials: WJ
authors.lastname: Larsen
authors.forename: S E
authors.initials: SE
authors.lastname: Wert
mesh_terms: D000818:Animals; D005314:Embryonic and Fetal Development; D005718:Gametogenesis; D006801:Humans; D007365:Intercellular Junctions / Q000502:physiology*