Shiga-like toxin production and connective tissue protein binding of Escherichia coli isolated from a patient with ulcerative colitis.
A 15-year-old girl with her first relapse of ulcerative colitis was treated with salicylazosulfapyridine, steroids, metronidazole and parenteral nutrition for 4 weeks without significant improvement. Her faecal specimens were negative for established intestinal pathogens, but strains of Escherichia coli producing Shiga-like toxin and expressing binding of fibronectin and collagen were repeatedly isolated. Neutralizing antibodies to Shiga-like toxin were detected in serum samples. Improvement was achieved during treatment with mecillinam to which the E. coli strains were sensitive.
Ljungh
A
A
Department of Pediatrics, S:t Göran Hospital, Stockholm, Sweden.
Eriksson
M
M
Eriksson
O
O
Henter
J I
JI
Wadström
T
T
D000293:Adolescent; D001427:Bacterial Toxins / Q000096:biosynthesis*; D003093:Colitis, Ulcerative / Q000382:microbiology*; D003094:Collagen / Q000378:metabolism*; D004926:Escherichia coli / Q000302:isolation & purification / Q000378:metabolism*; D005260:Female; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D022622:Shiga Toxin 1
D001427:Bacterial Toxins; D005353:Fibronectins; D022622:Shiga Toxin 1; D003094:Collagen