Class-switching from mu to gamma 3 or gamma 2b production at pre-B cell stage.
An Abelson virus-transformed murine pre-B cell line class-switched from mu to gamma 3 or gamma 2b at the pre-B stage during culture. A class-switch was mediated by the deletion mechanism of the intervening CH genes on the active chromosome. This study showed for the first time that class-switching at the pre-B cell stage was not always confined to gamma 2b production.
Sugiyama
H
H
Maeda
T
T
Akira
S
S
Kishimoto
S
S
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism*; D002872:Chromosome Deletion; D002999:Clone Cells / Q000378:metabolism; D007126:Immunoglobulin Allotypes / Q000096:biosynthesis / Q000145:classification* / Q000235:genetics; D007127:Immunoglobulin Constant Regions / Q000235:genetics; D007143:Immunoglobulin Heavy Chains / Q000096:biosynthesis* / Q000235:genetics; D007144:Immunoglobulin J-Chains / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D007142:Immunoglobulin gamma-Chains / Q000096:biosynthesis* / Q000235:genetics; D007148:Immunoglobulin mu-Chains / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D009693:Nucleic Acid Hybridization; D013234:Stem Cells / Q000378:metabolism*
D007126:Immunoglobulin Allotypes; D007127:Immunoglobulin Constant Regions; D007143:Immunoglobulin Heavy Chains; D007144:Immunoglobulin J-Chains; D007135:Immunoglobulin Variable Region; D007142:Immunoglobulin gamma-Chains; D007148:Immunoglobulin mu-Chains