Antithrombin III and protein C in stable angina pectoris--influence of dietary supplementation with polyunsaturated fatty acids.
The effect on plasma antithrombin III (AT III) and protein C on a supplement with polyunsaturated fatty acids (PUFA's) was investigated in a double-blind study in 36 patients with stable angina pectoris. All participants were given a supplement to their normal diets of vegetable oil (4.8 g n-6 PUFA's) for 4 weeks and were then randomized to the same oil or to fish oil (4.8 g n-3 PUFA's) for 12 weeks. Both oil supplements resulted in a statistically significant decrease in AT III activity, but there were no differences between the two different types of PUFA's. Antithrombin III antigen, protein C antigen or activity did not change significantly after either oil supplement. The background and significance for the decrease in antithrombin III activity induced by n-3 and n-6 PUFA's in patients with ischaemic heart disease is unknown.
Schmidt
E B
EB
Department of Clinical Chemistry and Cardiology, Aalborg Hospital, Denmark.
Kristensen
S D
SD
Sørensen
P J
PJ
Dyerberg
J
J
D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000178:diet therapy*; D000990:Antithrombin III / Q000032:analysis*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010938:Plant Oils / Q000008:administration & dosage; D011486:Protein C / Q000032:analysis*; D011897:Random Allocation
D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D010938:Plant Oils; D011486:Protein C; D000990:Antithrombin III