Ibopamine--how should it be used?
Ibopamine is an orally effective derivative of dopamine capable of eliciting peripheral and renal vasodilating activity and positive inotropic action. The compound is a prodrug which is enzymatically converted by plasma and peripheral tissues esterases to epinine (N-methyldopamine) which is the active drug. Effective plasma epinine levels are readily achieved, producing the hemodynamic action for 4-6 h. Acute and chronic studies demonstrated an improvement in cardiac output and a reduction in pre- and afterload.
Bussmann
W D
WD
Department of Cardiology, University Clinic, Frankfurt/Main, FRG.
Wienhöfer
K
K
Frik
R
R
D002316:Cardiotonic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003846:Deoxyepinephrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004298:Dopamine / Q000031:analogs & derivatives*; D006333:Heart Failure / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans
D002316:Cardiotonic Agents; C023487:ibopamine; D003846:Deoxyepinephrine; D004298:Dopamine