Biochemical pharmacology of Gilles de la Tourette's syndrome.
A comprehensive brief review of Tourette's syndrome has been presented. This included description of various symptoms display, neuropathological findings, biochemical and pharmacological studies. An outline of pharmacotherapy and pharmacological properties of agents used in management of Tourette's syndrome has been made. They were classified according to their effect in modulating biogenic amine systems. Drugs producing exacerbation of Tourette's syndrome were also surveyed. Biochemical and pharmacological hypotheses relevant to the underlying pathology of the disease have been addressed and discussed.
Messiha
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Department of Pharmacology, School of Medicine, University of North Dakota, Grand Forks 58202.
D001679:Biogenic Amines / Q000378:metabolism*; D006220:Haloperidol / Q000627:therapeutic use*; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D010868:Pimozide / Q000627:therapeutic use*; D005879:Tourette Syndrome / Q000188:drug therapy* / Q000378:metabolism
D001679:Biogenic Amines; D010868:Pimozide; D008094:Lithium; D006220:Haloperidol