A common antidonor reactive serological pattern in patients with failed kidney regrafts.
Twenty retransplant patients were serially screened for donor-reactive antibodies (DRA). DRA appeared exclusively in patients whose grafts permanently failed and these DRA shared some common features, namely early appearance (days 4-8 post-transplant), high titers (1:10 up to more than 1:400), and broad anti-HLA specificity. This preliminary data would suggest that regrafted patients with primary graft failure represent a distinct subgroup of particularly immune responsive individuals.
Groth
J
J
Abteilung Experimentelle Organtransplantation, Bereich Medizin Charité, Humboldt-Universität, Berlin, German Democratic Republic.
Bursche
M
M
Leverenz
S
S
Kaden
J
J
Scholz
D
D
D000918:Antibody Specificity; D006084:Graft Rejection; D006680:HLA Antigens; D006801:Humans; D007518:Isoantibodies / Q000096:biosynthesis*; D016030:Kidney Transplantation; D012086:Reoperation; D013997:Time Factors
D006680:HLA Antigens; D007518:Isoantibodies