Diltiazem inhibition of glucose-induced insulin secretion from the isolated perfused rat pancreas.
The effect of the calcium channel blocker diltiazem on stimulated insulin release from the isolated perfused rat pancreas was studied. Rats were treated for seven days with three dosages of diltiazem. Both phases of glucose-stimulated insulin secretion from the isolated perfused rat pancreas were diminished dose dependently.
Fehmann
H C
HC
Department of Medicine, University of Göttingen, F.R.G.
Stöckmann
F
F
Haverich
R
R
Creutzfeldt
W
W
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004110:Diltiazem / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D007328:Insulin; D004110:Diltiazem; D005947:Glucose