Effect of subchronic treatment with methamphetamine on apomorphine-induced changes in locomotor activity in mice.
Subchronic treatment with methamphetamine (3 mg/kg, s.c., twice daily for 14 days) attenuated hypomotility produced by a low dose of apomorphine (0.1 mg/kg, s.c.) and enhanced hypermotility induced by a high dose of apomorphine (3 mg/kg, s.c.) in mice. The treatment did not affect apomorphine-induced decrease in striatal DOPA accumulation following gamma-butyrolactone plus m-hydroxybenzylhydrazine, an L-amino acid decarboxylase inhibitor, administration. These results suggest that drug sensitivity of presynaptic dopamine receptors in the striatum may not be altered after subchronic methamphetamine treatment.
Watanabe
H
H
Taniguchi
M
M
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004357:Drug Synergism; D006834:Hydrazines / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*
D006834:Hydrazines; D008694:Methamphetamine; D004295:Dihydroxyphenylalanine; C004297:3-hydroxybenzylhydrazine; D001058:Apomorphine