Physical dependence on clonazepam in dogs.
Six dogs were, under constant environmental conditions, treated for 7 weeks with clonazepam (0.5 mg/kg b.i.d. orally). Already after 1 week of treatment, slight symptoms of withdrawal could be elicited by intravenous injection of flumazepil (Ro 15-1788). When clonazepam was finally withdrawn, a self-limiting abstinence syndrome was observed in all dogs, consisting of behavioral alterations (listlessness, wet dog shakes, dorsal recumbency), tremor, a severe clonic-tonic seizure in 1 case, hyperthermia, and weight loss. The syndrome was most pronounced on days 2 and 3 after withdrawal, after 1 week all signs of physical dependence had disappeared.
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D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology / Q000633:toxicity; D001831:Body Temperature; D001835:Body Weight; D002998:Clonazepam / Q000633:toxicity; D004285:Dogs; D005260:Female; D005442:Flumazenil; D008297:Male; D012640:Seizures / Q000139:chemically induced; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders; D014202:Tremor / Q000139:chemically induced
D001570:Benzodiazepinones; D005442:Flumazenil; D002998:Clonazepam