title: Comparison of 2% hydroxypropyl methylcellulose and 1% sodium hyaluronate in implant surgery.
abstract: We conducted a prospective randomized clinical trial of 2% hydroxypropyl methylcellulose and 1% sodium hyaluronate (Healon) in routine extracapsular cataract surgery with implantation of a posterior chamber intraocular lens. Of the 84 patients 40 received methylcellulose and 44 received sodium hyaluronate. There was no statistically significant difference in endothelial-cell loss or induced cellular polymegathism between the two groups. The intraocular pressure before and after surgery was similar in the two groups, as was the visual acuity 8 weeks after surgery. The results suggest that 2% hydroxypropyl methylcellulose is a safe and effective alternative to 1% sodium hyaluronate in routine implant surgery.
authors.affiliation: Department of Ophthalmology, Toronto General Hospital, Ont.
authors.forename: K
authors.initials: K
authors.lastname: Hazariwala
authors.forename: C B
authors.initials: CB
authors.lastname: Mortimer
authors.forename: A R
authors.initials: AR
authors.lastname: Slomovic
mesh_terms: D002387:Cataract Extraction / Q000009:adverse effects; D002986:Clinical Trials as Topic; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D065347:Hypromellose Derivatives; D007910:Lenses, Intraocular / Q000009:adverse effects; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D065347:Hypromellose Derivatives; D006820:Hyaluronic Acid; D008747:Methylcellulose