title: Mammalian metallothionein is functional in yeast.
abstract: Expression of two monkey metallothioneins in yeast leads to complementation of both known functions of the endogenous yeast copperthionein gene, namely copper detoxification and autoregulation of transcription. The metallothionein-like proteins of higher and lower eukaryotes are therefore functionally analogous despite their dissimilar primary sequences.
authors.forename: D J
authors.initials: DJ
authors.lastname: Thiele
authors.forename: M J
authors.initials: MJ
authors.lastname: Walling
authors.forename: D H
authors.initials: DH
authors.lastname: Hamer
mesh_terms: D000818:Animals; D003300:Copper / Q000378:metabolism; D005786:Gene Expression Regulation; D005816:Genetic Complementation Test; D000882:Haplorhini; D008668:Metallothionein / Q000235:genetics / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D013045:Species Specificity; D013329:Structure-Activity Relationship; D014170:Transformation, Genetic
chemical_list: D003300:Copper; D008668:Metallothionein