title: Shiga-like toxin production and connective tissue protein binding of Escherichia coli isolated from a patient with ulcerative colitis.
abstract: A 15-year-old girl with her first relapse of ulcerative colitis was treated with salicylazosulfapyridine, steroids, metronidazole and parenteral nutrition for 4 weeks without significant improvement. Her faecal specimens were negative for established intestinal pathogens, but strains of Escherichia coli producing Shiga-like toxin and expressing binding of fibronectin and collagen were repeatedly isolated. Neutralizing antibodies to Shiga-like toxin were detected in serum samples. Improvement was achieved during treatment with mecillinam to which the E. coli strains were sensitive.
authors.affiliation: Department of Pediatrics, S:t Göran Hospital, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Ljungh
authors.forename: M
authors.initials: M
authors.lastname: Eriksson
authors.forename: O
authors.initials: O
authors.lastname: Eriksson
authors.forename: J I
authors.initials: JI
authors.lastname: Henter
authors.forename: T
authors.initials: T
authors.lastname: Wadström
mesh_terms: D000293:Adolescent; D001427:Bacterial Toxins / Q000096:biosynthesis*; D003093:Colitis, Ulcerative / Q000382:microbiology*; D003094:Collagen / Q000378:metabolism*; D004926:Escherichia coli / Q000302:isolation & purification / Q000378:metabolism*; D005260:Female; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D022622:Shiga Toxin 1
chemical_list: D001427:Bacterial Toxins; D005353:Fibronectins; D022622:Shiga Toxin 1; D003094:Collagen