title: Levobunolol compared with timolol: a four-year study.
abstract: Fifty-one patients with raised intraocular pressure (IOP) were treated for up to four years with one of three ophthalmic solutions: 0.5% levobunolol, 1% levobunolol, or 0.5% timolol. The study was conducted as a double-masked, randomised trial in which medications were administered twice daily to both eyes. Levobunolol and timolol were equally effective in reducing overall mean IOP; reductions were greater than 8.8 mmHg in all three treatment groups. The study showed levobunolol to be as safe and effective as timolol in the long-term control of raised IOP.
authors.affiliation: Department of Ophthalmology, Ichilove Medical Center, Sackler School of Medicine, University of Tel Aviv, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Geyer
authors.forename: M
authors.initials: M
authors.lastname: Lazar
authors.forename: G D
authors.initials: GD
authors.lastname: Novack
authors.forename: D
authors.initials: D
authors.lastname: Shen
authors.forename: C Y
authors.initials: CY
authors.lastname: Eto
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D002040:Levobunolol / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013999:Timolol / Q000627:therapeutic use*; D014794:Visual Fields / Q000187:drug effects
chemical_list: D013999:Timolol; D002040:Levobunolol