The potential use of mechanism-based enzyme inactivators in medicine.
Mechanism-based enzyme inactivator, alanine racemase, S-adenosylhomocysteine hydrolase, D-amino acid aminotransferase, gamma-aminobutyric acid aminotransferase, arginine decarboxylase, aromatase, L-aromatic amino acid decarboxylase, dihydrofolate reductase, dihydroorotate dehydrogenase DNA polymerase I, dopamine beta-hydroxylase, histidine decarboxylase, beta-lactamase, monoamine oxidase, ornithine decarboxylase, serine proteases, testosterone 5 alpha-reductase, thymidylate synthetase, xanthine oxidase.
Silverman
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RB
Department of Chemistry, Northwestern Univesity, Evanston, Illinois 60208.
D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors