title: Autocrine or paracrine models of cytokine production and utilization in B-cell chronic lymphocytic leukaemia.
abstract: The possibility that autocrine or paracrine mechanisms of cytokine production and utilization may take place in patients with B-cell chronic lymphocytic leukaemia (B-CLL) is discussed. In particular, evidence is provided for a likely role of interleukin 2 (IL2) on the neoplastic B-cell compartment. Furthermore, the possibility that tumor necrosis factor (TNF) may also be involved is suggested.
authors.affiliation: Dipartimento di Scienze Biomediche e Oncologia Umana, University of Torino, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Foa
authors.forename: M
authors.initials: M
authors.lastname: Giovarelli
authors.forename: M T
authors.initials: MT
authors.lastname: Fierro
authors.forename: M
authors.initials: M
authors.lastname: Bonferroni
authors.forename: G
authors.initials: G
authors.lastname: Forni
mesh_terms: D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000502:physiology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism*; D008954:Models, Biological; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000502:physiology
chemical_list: D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha