FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics.
A PAF antagonist, designated as FR-900452, was isolated from fermentation products of Streptomyces phaeofaciens and the molecular formula was determined as C22H25N3O3S. The compound inhibited PAF-induced rabbit platelet aggregation with an IC50 of 3.7 X 10(-7)M, but was much less active against collagen-, arachidonic acid- or ADP-induced aggregation (IC50; 6.4 X 10(-5), greater than 10(-4) or greater than 10(-4)M, respectively).
Okamoto
M
M
Yoshida
K
K
Nishikawa
M
M
Ando
T
T
Iwami
M
M
Kohsaka
M
M
Aoki
H
H
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003094:Collagen / Q000494:pharmacology; D005285:Fermentation; D007211:Indoles; D010879:Piperazines; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors* / Q000302:isolation & purification / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D001095:Arachidonic Acids; D007211:Indoles; D010879:Piperazines; D010972:Platelet Activating Factor; C048269:FR 900452; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate; D003094:Collagen