Biological activities of interleukins and colony-stimulating factors.
The complementary DNAs encoding interleukins (interleukins 1, 2, 3, 4, 5 and 6) and colony-stimulating factors (granulocyte-macrophage, granulocyte, and macrophage colony-stimulating factors) have been cloned. These DNA clones have allowed the large-scale production of recombinant forms of these cytokines and the extensive studies of their biological activities. These advances have led to a much better understanding of the role of these cytokines in regulation of immune responses and hematopoiesis, and have clarified that these cytokines have multiple effects on various types of cells.
Kitagawa
S
S
Division of Hemopoiesis, Jichi Medical School, Tochigi-ken, Japan.
Saito
M
M
D000818:Animals; D003115:Colony-Stimulating Factors / Q000502:physiology*; D006410:Hematopoiesis / Q000502:physiology; D006801:Humans; D007109:Immunity / Q000502:physiology; D007378:Interleukins / Q000502:physiology*
D003115:Colony-Stimulating Factors; D007378:Interleukins