Human peritoneal macrophages: clinical models of inflammation and potential targets of antiinflammatory drugs.
Human peritoneal macrophages have been obtained from patients with renal disease undergoing chronic peritoneal dialysis, patients with ascites and at laparoscopy. These macrophages in general have both morphological and enzymatic characteristics of activated macrophages, as judged by criteria derived from animal experiments. Human peritoneal macrophages produce a variety of eicosanoids, including leukotriene B4 and leukotriene C4. These cells are suitable for studies on in vitro and in vivo effects of drugs, and for investigation of changes in macrophage activity occurring in human diseases.
Wilson
J H
JH
Bonta
I L
IL
D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D004537:Eicosanoic Acids / Q000096:biosynthesis / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects*; D008954:Models, Biological; D010529:Peritoneal Cavity / Q000166:cytology
D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D004537:Eicosanoic Acids; D016718:Arachidonic Acid