title: Chromosome assignment of the gene loci ETS1 and THY1 in the owl monkey.
abstract: Our previous assignment of the gene loci HBB, HRAS1, INS, PTH, LDHA, and CAT to owl monkey chromosome 19 of karyotype VI (K-VI) indicated a putative homology of this owl monkey chromosome with the short arm of human chromosome 11 (HSA 11p). To investigate further the extent of shared homology, we localized in the owl monkey complement two genes known to be on HSA 11q. Segregation analysis of ETS1 and THY1 homologous DNA in three karyotypically different panels of rodent x owl monkey somatic cell hybrids provided evidence for the syntenic assignment of these loci to homologous chromosomes of three owl monkey karyotypes, namely, chromosomes 4 (K-VI), 3 (K-II), and 5 (K-V). The results indicate a disruption of syntenic gene loci on the distal portion of HSA 11q from 11p during primate evolution.
authors.affiliation: New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772.
authors.forename: N S
authors.initials: NS
authors.lastname: Ma
authors.forename: D S
authors.initials: DS
authors.lastname: Gerhard
authors.forename: D S
authors.initials: DS
authors.lastname: Gerard
mesh_terms: D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D001029:Aotus trivirgatus / Q000235:genetics*; D015139:Blotting, Southern; D002427:Cebidae / Q000235:genetics*; D002874:Chromosome Mapping; D015342:DNA Probes; D050784:Proto-Oncogene Protein c-ets-1; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D015342:DNA Probes; C494041:ETS1 protein, human; D050784:Proto-Oncogene Protein c-ets-1; D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors