title: [Genetic determinants of antibiotic resistance in gram negative bacteria].
abstract: Modern data on spreading, structural and functional organization and evolution of the genetic determinants of antibiotic resistance in the gram-negative bacteria are reviewed. Some mechanisms for resistance to trimethoprime, sulphonamides, tetracyclines, chloramphenicol aminoglycosides, beta-lactam antibiotics controlled by the plasmid and chromosomal genes are presented. The problem of using the molecular DNA-probes containing the genetical determinants for antibiotic resistance in the practical work of clinical laboratories is discussed.
authors.forename: L A
authors.initials: LA
authors.lastname: Anisimova
authors.forename: A M
authors.initials: AM
authors.lastname: Boronin
mesh_terms: D004352:Drug Resistance, Microbial / Q000235:genetics*; D005798:Genes, Bacterial; D006090:Gram-Negative Bacteria / Q000235:genetics*; D010957:Plasmids
vernacular_title: Geneticheskie determinanty rezistentnosti k antibiotikam gramotritsatel'nykh bakteriĭ.