Molecular aspects of reovirus-host cell interaction.
Reovirus biology is defined, in the main, by the sigma 1 cell attachment protein located in the virion outer capsid. Interaction of the sigma 1 protein with serotype-specific receptor molecules located on the surface of target cells determines the tropism and virulence of the virus and mediates viral inhibition of target cell growth.
Cohen
J A
JA
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19104.
Williams
W V
WV
Greene
M I
MI
D000595:Amino Acid Sequence; D000818:Animals; D036022:Capsid Proteins; D002448:Cell Adhesion; D006790:Host-Parasite Interactions; D006801:Humans; D012089:Mammalian orthoreovirus 3 / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D011991:Receptors, Virus / Q000235:genetics / Q000502:physiology; D012087:Reoviridae / Q000502:physiology*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
D036022:Capsid Proteins; D011991:Receptors, Virus; D014764:Viral Proteins; C046176:reovirus type 3 receptor; C031728:sigma 1 protein, reovirus