Influence of different indwelling lines on the measurement of blood cyclosporin A levels.
We studied in vivo and in vitro the possible influence of the indwelling line on the measurement of cyclosporin A (CSA) levels. CSA levels measured in samples taken from the catheter lumen used for CSA administration were significantly higher than those taken either from a second lumen or from a peripheral vein. Reversible fixation of the drug to the catheter walls might explain this alteration. The degree of fixation varies for different types of plastic material.
Carreras
E
E
Postgraduate School of Hematology, Hospital Clinic, University of Barcelona, Spain.
Lozano
M
M
Deulofeu
R
R
Roman
S
S
Grañena
A
A
Rozman
C
C
D016026:Bone Marrow Transplantation; D002406:Catheterization, Peripheral; D002408:Catheters, Indwelling; D003524:Cyclosporins / Q000008:administration & dosage / Q000097:blood*; D006801:Humans
D003524:Cyclosporins