Long-term total intraperitoneal nutrition in a rabbit model.
Total intraperitoneal (IP) nutrition was studied in a rabbit model. A mixture of 10% dextrose, 2% amino acids, and 3% lipids was continuously administered to 28 rabbits as their sole nutritional source for 21 days. Twenty rabbits received the solution via IP catheters; 8 of these underwent 50% small bowel resection (SBR) prior to IP infusion. As controls, 8 rabbits were administered the same solution intravenously (IV-TPN). Survival was 75% in both experimental and control groups. Weight gain was similar in IV- and IP-infused rabbits after 21 days. No significant decrease in body weight or changes in blood chemistry occurred after 50% SBR. A mild chemical peritonitis was seen with IP nutrition which resolved after discontinuing the infusions. Biochemical and histologic liver toxicity was more severe in the IV controls than the IP-infused rabbits. We conclude total calorie support can be delivered thorough the peritoneal cavity on a long-term basis; 50% SBR minimally affects IP absorption of nutrients; and the liver dysfunction seen after IV-nutrition is less severe with IP nutrition.
Stone
M M
MM
Mulvihill
S J
SJ
Lewin
K J
KJ
Fonkalsrud
E W
EW
D000818:Animals; D001835:Body Weight; D002408:Catheters, Indwelling; D005526:Food, Formulated; D008099:Liver / Q000473:pathology; D010289:Parenteral Nutrition, Total / Q000379:methods*; D010529:Peritoneal Cavity; D010537:Peritoneum / Q000473:pathology; D011817:Rabbits; D013997:Time Factors