[Effects of cranial radiotherapy on growth and hypothalamo-hypophyseal function].
Aiming at evaluating the possible adverse effects of the use of radiotherapy on the CNS in children, we studied fourteen patients in whom it was used: seven as part of the conventional prophylaxis we use in malignant lymphoproliferative processes (group I) and the remaining seven as a treatment for primary cerebral tumors (group II). We evaluated growth during periods ranging from 1.5 to 11 years, and also hypothalamic-pituitary function by RIA. We comment on the results and confirm the endocrine alterations, especially the deficit of growth hormone.
Morón Bayón
C
C
Departamento de Pediatría, Hospital General de Asturias, Oviedo.
Antuña García
M J
MJ
Fernández
C
C
Gudín
G
G
Rodríguez
R
R
Sastre
L
L
D001932:Brain Neoplasms / Q000503:physiopathology / Q000532:radiotherapy*; D002648:Child; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology / Q000528:radiation effects*; D007223:Infant; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000503:physiopathology / Q000532:radiotherapy; D008228:Lymphoma, Non-Hodgkin / Q000503:physiopathology / Q000532:radiotherapy; D008232:Lymphoproliferative Disorders / Q000503:physiopathology / Q000532:radiotherapy*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000503:physiopathology / Q000532:radiotherapy; D011878:Radiotherapy / Q000009:adverse effects; D012886:Skull / Q000528:radiation effects*
Efectos del empleo de la radioterapia craneal sobre el crecimiento y función hipotálamo-hipofisaria.