The pharmacokinetics of R- and S-tocainide in patients with acute ventricular arrhythmias.
The pharmacokinetics of R(-) and S(+)- tocainide were studied in twelve patients requiring intravenous tocainide. In all patients, a progressive increase in the S(+):R(-) ratio was observed during the infusion. Mean +/- s.d. ratios increased from 1.03 +/- 0.05 at 2 min to 1.76 +/- 0.35 at 48.5 h. Data from eight patients were fitted to a two-compartment model and there was a significant difference (Wilcoxon matched-pairs test P less than 0.01) in the clearance estimates for the two enantiomers. The median values were: S(+)-tocainide = 6.25 l h-1 and R(-)-tocainide = 9.31 l h-1. There was no differences in V1 or Vss.
Thomson
A H
AH
Murdoch
G
G
Pottage
A
A
Kelman
A W
AW
Whiting
B
B
Hillis
W S
WS
D000208:Acute Disease; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000097:blood*; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007700:Kinetics; D008012:Lidocaine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood; D008297:Male; D008875:Middle Aged; D013237:Stereoisomerism; D013997:Time Factors; D016677:Tocainide
D000889:Anti-Arrhythmia Agents; D016677:Tocainide; D008012:Lidocaine