title: Evaluation of the effect of topical steroids on human scar contracture using a nude mouse model.
abstract: Adult nude mice had 1.5 to 1.0 meshed split-thickness human skin applied to an excised area of their back. The animals were then randomized into two groups, one of which had a steroid cream applied to their graft on alternate days. The other group had no ointment applied and served as a control. The wounds were measured on a weekly basis and the rate of wound contracture was found to be identical. Topical steroids would thus appear to offer no benefit in the prevention of scar contracture.
authors.affiliation: Shriners Burns Institute, Cincinnati Unit.
authors.forename: J P
authors.initials: JP
authors.lastname: Waymack
authors.forename: E
authors.initials: E
authors.lastname: Robb
authors.forename: R
authors.initials: R
authors.lastname: Plessinger
authors.forename: G D
authors.initials: GD
authors.lastname: Warden
authors.forename: J W
authors.initials: JW
authors.lastname: Alexander
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000188:drug therapy*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D016038:Skin Transplantation; D014183:Transplantation, Heterologous; D014222:Triamcinolone Acetonide / Q000627:therapeutic use*
chemical_list: D014222:Triamcinolone Acetonide