title: Pancreatic B-cell function in relation to diabetic retinopathy in Asian Indian NIDDM patients.
abstract: Pancreatic B-cell function in relation to diabetic retinopathy was studied in 195 NIDDM patients with long-standing diabetes. Background diabetic retinopathy (BDR) was present in 95 (48.7%) and proliferative retinopathy (PDR) in 17 (8.7%) of the subjects. There was no significant difference between the BDR, PDR, and non-retinopathy groups with respect to age, age at diagnosis of diabetes and HbA1 values. Mean duration of diabetes was higher in the PDR group (p less than 0.05). Serum C-peptide values showed no correlation with the presence of retinopathy or with the duration of diabetes. The C-peptide values were widely scattered in patients with BDR and PDR showing no association between pancreatic B-cell reserve and occurrence or severity of retinopathy in NIDDM patients. Thus, decreased pancreatic B-cell reserve does not appear to be a risk factor for diabetic retinopathy in NIDDM patients.
authors.affiliation: Diabetes Research Centre, Madras, India.
authors.forename: C
authors.initials: C
authors.lastname: Snehalatha
authors.forename: R
authors.initials: R
authors.lastname: Mohan
authors.forename: V
authors.initials: V
authors.lastname: Mohan
authors.forename: A
authors.initials: A
authors.lastname: Ramachandran
authors.forename: M
authors.initials: M
authors.lastname: Viswanathan
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007194:India; D007515:Islets of Langerhans / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood; D044465:White People
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D006442:Glycated Hemoglobin; D014280:Triglycerides