Translocation t(1;7) revisited. Report of three further cases and review.
Three white patients, two with myelofibrosis and one with refractory anemia, presented with a t(1;7). The clinical and cytogenetic findings are discussed in the context of 45 cases already published. Rather than the specific association of t(1;7) with a particular hematologic disorder, a review of the literature strongly suggests correlation with therapeutic or environmental exposure to toxic substances. The proposed mechanisms to explain the origin of t(1;7) are briefly reviewed.
Willem
P
P
Department of Human Genetics, School of Pathology, South African Institute for Medical Research, Johannesburg.
Pinto
M
M
Bernstein
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000753:Anemia, Refractory / Q000235:genetics*; D002648:Child; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000235:genetics*; D014178:Translocation, Genetic
D005819:Genetic Markers