title: Development of spindle-shaped cells and chondroid cells from androgen-dependent Shionogi carcinoma 115. A light and electron microscopic study.
abstract: Androgen-dependent Shionogi carcinoma 115 (SC115) is an undifferentiated medullary carcinoma consisting of compact round cells. However, when host male DS mice were castrated 2 weeks after tumor transplantation, tumors composed of compact round cells, spindle-shaped cells and chondroid cells grew 4 weeks after castration. Compact round cells with desmosomes were arranged in solid nests and exhibited immunoreactivity for keratin protein. Spindle-shaped cells had prominent rough endoplasmic reticulum, and appeared to secrete collagen. Chondroid cells had the characteristics of chondrocytes. The light and electron microscopic features were highly suggestive of a transition from compact round cells to spindle-shaped cells, and from spindle-shaped cells to chondroid cells. The histology of this tumor thus suggests that SC115 cells are able to change into chondroid cells via spindle-shaped cells.
authors.affiliation: Department of Pathology, Center for Adult Diseases, Osaka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Terada
authors.forename: R
authors.initials: R
authors.lastname: Yamamoto
authors.forename: N
authors.initials: N
authors.lastname: Uchida
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Takada
authors.forename: H
authors.initials: H
authors.lastname: Taniguchi
authors.forename: M
authors.initials: M
authors.lastname: Tsuji
authors.forename: Y
authors.initials: Y
authors.lastname: Kitamura
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
mesh_terms: D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D002356:Cartilage / Q000473:pathology*; D003094:Collagen / Q000032:analysis; D006651:Histocytochemistry; D007124:Immunoenzyme Techniques; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D009919:Orchiectomy; D011509:Proteoglycans / Q000032:analysis
chemical_list: D000728:Androgens; D011509:Proteoglycans; D003094:Collagen