title: Biology and mode of action of pure antioestrogens.
abstract: The properties of ICI 164,384, a 7 alpha-alkyl amide analogue of 17 beta-oestradiol, are described and contrasted with those of tamoxifen. These studies demonstrate that ICI 164,384 has many of the characteristics of a pure antioestrogen.
authors.affiliation: ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, UK.
authors.forename: A E
authors.initials: AE
authors.lastname: Wakeling
authors.forename: J
authors.initials: J
authors.lastname: Bowler
mesh_terms: D000818:Animals; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004965:Estrogen Antagonists / Q000494:pharmacology*; D006801:Humans; D053284:Polyunsaturated Alkamides; D013629:Tamoxifen / Q000494:pharmacology
chemical_list: D004965:Estrogen Antagonists; D053284:Polyunsaturated Alkamides; D013629:Tamoxifen; D004958:Estradiol; C051781:ICI 164384