title: Clinical picture and problems of keratoplasty in Richner-Hanhart syndrome (tyrosinemia type II).
abstract: The Richner-Hanhart syndrome seen in a middle-aged woman is described. The patient had the typical clinical manifestations of tyrosinemia II with a bilateral keratopathy, palmar and plantar hyperkeratosis. The patient was subjected to a specific diet and to perforating keratoplasty. Postoperative systemic therapy with steroids had a negative influence on the clinical manifestations; dendritic lesions which developed on the corneal graft disappeared after interruption of the systemic steroid therapy. This suggests that cortisone treatment after keratoplasty should be avoided in this special metabolic disorder.
authors.affiliation: University Eye Hospital of Hamburg, FRG.
authors.forename: R B
authors.initials: RB
authors.lastname: Sayar
authors.forename: D
authors.initials: D
authors.lastname: von Domarus
authors.forename: H J
authors.initials: HJ
authors.lastname: Schäfer
authors.forename: G
authors.initials: G
authors.lastname: Beckenkamp
mesh_terms: D000592:Amino Acid Metabolism, Inborn Errors / Q000145:classification* / Q000150:complications / Q000601:surgery; D003315:Cornea / Q000473:pathology / Q000648:ultrastructure; D003318:Corneal Opacity / Q000473:pathology / Q000601:surgery*; D016039:Corneal Transplantation; D003348:Cortisone / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005533:Foot Dermatoses / Q000150:complications / Q000473:pathology; D006229:Hand Dermatoses / Q000150:complications / Q000473:pathology; D006801:Humans; D007642:Keratosis / Q000150:complications / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D014443:Tyrosine / Q000097:blood*
chemical_list: D014443:Tyrosine; D003348:Cortisone