Lectin-binding sites in eccrine sweat gland tumours.
Lectin-binding sites in sections of formalin-fixed, paraffin-embedded eccrine sweat gland tumours were investigated using fluorescein isothiocyanate (FITC) conjugated peanut agglutinin (PNA), FITC conjugated Ricinus communis 1 agglutinin (RCA-1) and FITC conjugated wheat germ agglutinin (WGA). In 22 benign eccrine sweat gland tumours, lectin-binding sites were noted primarily on the cell surface, and in the secretions. In five malignant sweat gland tumours, all showed cytoplasmic lectin-binding sites in variable proportions of malignant cells in addition to cell surface staining. These results indicate that cytoplasmic lectin-binding sites may be a useful marker of neoplastic transformation of eccrine sweat gland tumours.
Tamaki
K
K
Furue
M
M
Seki
Y
Y
Inoue
Y
Y
Tsuchida
T
T
Ohara
K
K
Kukita
A
A
D002462:Cell Membrane / Q000276:immunology; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D003593:Cytoplasm / Q000276:immunology; D004439:Eccrine Glands; D016650:Fluorescein-5-isothiocyanate; D005452:Fluoresceins; D006801:Humans; D011975:Receptors, Mitogen / Q000032:analysis*; D013544:Sweat Gland Neoplasms / Q000276:immunology*; D013545:Sweat Glands; D013861:Thiocyanates
D005452:Fluoresceins; D011975:Receptors, Mitogen; D013861:Thiocyanates; D016650:Fluorescein-5-isothiocyanate