A review of photoradiation therapy in the management of central nervous system tumours.
Photoradiation therapy depends on the selective retention of a photosensitizer within the tumour followed by activation of the sensitizer by irradiating the tumour with light of the appropriate wavelength. The present methods of treatment of cerebral glioma are inadequate and the possible benefit of utilizing photoradiation therapy to obtain improved local control of the tumour has been studied in the laboratory and in clinical trials. The biological basis for photoradiation therapy and the laboratory studies and clinical trials involving the use of photoradiation therapy to treat cerebral tumours are discussed.
Kaye
A H
AH
Department of Neurosurgery, Higginbotham Neuroscience Research Laboratory, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria.
Hill
J S
JS
D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D005910:Glioma / Q000188:drug therapy* / Q000378:metabolism; D006414:Hematoporphyrin Photoradiation / Q000009:adverse effects / Q000379:methods*; D006415:Hematoporphyrins / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D051381:Rats
D006415:Hematoporphyrins