Prostaglandin I2 and the constricted maternal ovine placenta: effects of local infusion and placental age.
We have tested the hypotheses that systemic responses to the infusion of prostaglandin I2 may have masked the ability of this substance to dilate the maternal placenta and that the inability of prostaglandin I2 to dilate the maternal near-term placenta may be a function of placental age. Regional blood flows were measured with radioactive microspheres. In 8 near-term sheep the control flows were measured and angiotensin II (AII) infusion was begun at 5 micrograms/min and continued for the duration of the experiments. At t = 15 min, regional blood flows were again measured. Prostaglandin I2 was then infused via a retrograde uterine arterial catheter at 10 micrograms/min. At t = 30 min, the flows were again measured. At this time the infusion of prostaglandin I2 was stopped and at t = 45 min the blood flows were measured for the last time. AII increased the resistance of all tissues examined. The blood pressure increased with AII and did not change thereafter. The non-placental uterine tissue served by the retrograde catheter dilated with prostaglandin I2. The placental tissue had an initial resistance of 59 +/- 6 mmHg.ml-1.min.g which increased to 98 +/- 22 mmHg.ml-1.min.g with the infusion of AII (P less than 0.05). This resistance remained constant at 82 +/- 19 mmHg.ml-1.min.g with the administration of prostaglandin I2 and did not change after prostaglandin I2 was removed. The local application of prostaglandin I2 in the presence of AII induced vasoconstriction caused vasodilatation in the nonplacental vessels but could not change the AII induced constriction in the placental vasculature.(ABSTRACT TRUNCATED AT 250 WORDS)
Rankin
J H
JH
Department of Obstetrics-Gynecology, University of Wisconsin, Madison 53706.
Landauer
M
M
Neaves
N
N
Tian
Q
Q
Phernetton
T M
TM
D000367:Age Factors; D000818:Animals; D011464:Epoprostenol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005865:Gestational Age; D007261:Infusions, Intra-Arterial; D010920:Placenta / Q000098:blood supply / Q000187:drug effects*; D011247:Pregnancy; D012756:Sheep / Q000502:physiology*; D014469:Umbilical Arteries; D014661:Vasoconstriction / Q000187:drug effects*
D011464:Epoprostenol