Alterations in lipid metabolism induced by antihypertensive therapy.
Adverse effects on serum triglycerides and cholesterol fractions have been reported in hypertensive patients treated with diuretics and non-selective beta-blockers. However, the changes induced by cardioselective beta-blockers and those with intrinsic sympathomimetic activity (ISA) or by alpha-blockers have been shown to be more favourable. In addition, evidence suggests that calcium antagonists and angiotensin-converting enzyme (ACE) inhibitors have little effect on serum lipid concentrations in hypertensive patients, although until now only diuretics and beta-blockers without ISA have been shown to reduce morbidity and mortality.
Amery
A
A
Department of Pathophysiology, Catholic University of Leuven, Belgium.
Lijnen
P
P
D000959:Antihypertensive Agents / Q000009:adverse effects*; D002784:Cholesterol / Q000097:blood*; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D014280:Triglycerides / Q000097:blood*
D000959:Antihypertensive Agents; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol