title: Immunohistochemical analysis of the ras oncogene protein product in human thyroid neoplasms.
abstract: The monoclonal antibody Y13 259 to the ras oncogene p21 product was used in an immunohistochemical study of ras expression in human thyroid neoplasms. Both papillary and follicular carcinomas showed consistently higher staining intensity than normal tissue adjacent to carcinomas. Some follicular, foetal, embryonal and oxyphil adenomas exhibited higher staining intensity than normal tissue. Our results suggest that elevated ras expression may be important in the development of some adenomas and in their conversion to carcinomas.
authors.affiliation: Ippokration General Hospital, Athens, Greece.
authors.forename: K
authors.initials: K
authors.lastname: Papadimitriou
authors.forename: M
authors.initials: M
authors.lastname: Yiagnisis
authors.forename: G
authors.initials: G
authors.lastname: Tolis
authors.forename: D A
authors.initials: DA
authors.lastname: Spandidos
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D000236:Adenoma / Q000235:genetics / Q000473:pathology; D000911:Antibodies, Monoclonal; D002291:Carcinoma, Papillary / Q000235:genetics / Q000473:pathology; D011905:Genes, ras; D006801:Humans; D007124:Immunoenzyme Techniques; D008565:Membrane Proteins / Q000032:analysis*; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D016283:Proto-Oncogene Proteins p21(ras); D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)