title: Sequential pathological studies in Japanese quails infected experimentally with Aspergillus fumigatus.
abstract: Intratracheal inoculation of young quail chicks with Aspergillus fumigatus spores resulted in the development of characteristic gross and microscopic lesions. The lesions were restricted to respiratory tract and there was no dissemination of infection to other tissues of the body. Gross changes in lungs and air sacs were observed within 24 hours and continued up to 20 days while in trachea these were noticed from the 3rd to the 9th day post-infection. The lesions, in general, included congestion and focal haemorrhages in the first 2 days followed by the development of varying-sized greyish-white nodules in the lungs, air sacs and trachea. Microscopic changes consisted of congestion, haemorrhages and a diffuse cellular infiltration in the first 2 days followed by granulomatous reaction with well developed granulomas in lungs, air sacs and trachea. Spores and developing hyphae of Aspergillus could be demonstrated in sections from 24 hours to 20 days of infection. Reisolation of the fungus was consistently achieved from the lungs, air sacs and trachea up to 14 days.
authors.affiliation: Department of Veterinary Pathology, Haryana Agricultural University, Hissar, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Chaudhary
authors.forename: J R
authors.initials: JR
authors.lastname: Sadana
authors.forename: A K
authors.initials: AK
authors.lastname: Pruthi
mesh_terms: D000400:Air Sacs / Q000473:pathology*; D000818:Animals; D001228:Aspergillosis / Q000473:pathology*; D001232:Aspergillus fumigatus; D003370:Coturnix; D006099:Granuloma / Q000473:pathology; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology*; D008172:Lung Diseases, Fungal / Q000473:pathology*; D014132:Trachea / Q000473:pathology*