Pharmacological basis of the classification of calcium antagonists.
In this brief account of Ca antagonists, I have attempted to illustrate similarities and differences among selective Ca antagonists. Four typical pharmacological profiles may be recognized by taking into account studies at molecular, cellular and tissular levels. This gives a rational basis for understanding that all calcium antagonists do not show identical therapeutic actions.
Godfraind
T
T
Laboratoire de Pharmacodynamie Générale et de Pharmacologie, Université Catholique de Louvain, Bruxelles, Belgium.
D000818:Animals; D002121:Calcium Channel Blockers / Q000145:classification* / Q000493:pharmacokinetics / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D014018:Tissue Distribution
D002121:Calcium Channel Blockers