Spanish multicentre trial of recombinant somatropin. Spanish Collaborative Group.
A total of 42 patients (22 previously untreated and 20 previously treated) with GH deficiency were included in a Spanish multicentre trial of recombinant somatropin, 0.5 IU/kg/week. In previously untreated patients typical catch-up growth was observed and the height velocity increased from 3.3 +/- 0.6 cm/year to 9.8 +/- 2.4 cm/year during 1 year of therapy. In previously treated children, the height velocity was maintained (7.2 +/- 2.0 cm/year at the start and 7.9 +/- 1.6 cm/year after 1 year). No anti-GH antibodies were detected in previously untreated patients, and they disappeared from previously treated ones. No adverse reactions were reported.
Vicens-Calvet
E
E
Endocrinology Unit, Children's Hospital Vall d'Hebron, Barcelona, Spain.
Cuatrecasas-Membrado
J M
JM
D000917:Antibody Formation; D001827:Body Height / Q000187:drug effects; D002648:Child; D005260:Female; D013006:Growth Hormone / Q000172:deficiency* / Q000276:immunology; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic; D011994:Recombinant Proteins; D013030:Spain
D011994:Recombinant Proteins; D013006:Growth Hormone