The in vitro effect of amrinone on platelet aggregation in human whole blood.
Amrinone was found to inhibit platelet aggregation in human whole blood in a dose dependent manner, and at physiological levels of the drug. Statistically significant drug-related decreases in aggregation were observed with collagen, ADP and arachidonic acid. Inhibition of aggregation was most marked with arachidonic acid, where greater than 90% inhibition was achieved at a drug concentration of 25 mugml-1. The aggregation profiles presented indicate that amrinone inhibits aggregation primarily through inhibition of thromboxane A2 synthesis.
Pattison
A
A
Eason
C T
CT
Bonner
F W
FW
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000631:Aminopyridines / Q000494:pharmacology*; D000676:Amrinone; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D013928:Thromboxane A2 / Q000097:blood
D000631:Aminopyridines; D001095:Arachidonic Acids; D016718:Arachidonic Acid; D013928:Thromboxane A2; D000244:Adenosine Diphosphate; D003094:Collagen; D000676:Amrinone