title: Genetics of resistance to Salmonella typhimurium in newly hatched chicks.
abstract: 1. A survey of inbred and partially inbred lines of chickens showed pronounced differences in mortality following challenge of the newly hatched chicks with Salmonella typhimurium. Lines W, 6(1) and N were highly resistant to challenge, whereas lines C and 15I were highly susceptible. 2. This difference in susceptibility was observed with a range of 5 strains of S. typhimurium of different degrees of virulence and also following both oral and intramuscular challenge. 3. The inheritance of resistance was studied in detail by examining a series of crosses between the susceptible line C and resistant line W. The pattern of mortality in crosses and back-crosses between these lines indicated resistance is dominant and was consistent with the inheritance of a dominant autosomal resistance gene. 4. There was no evidence of maternal effects in these crosses, and no evidence of association with the major histocompatability complex.
authors.affiliation: Houghton Poultry Research Station, Huntingdon, Cambs, England.
authors.forename: N
authors.initials: N
authors.lastname: Bumstead
authors.forename: P A
authors.initials: PA
authors.lastname: Barrow
mesh_terms: D000818:Animals; D002645:Chickens / Q000235:genetics*; D003433:Crosses, Genetic; D004198:Disease Susceptibility; D007113:Immunity, Innate; D007178:Inbreeding; D011201:Poultry Diseases / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D012481:Salmonella Infections, Animal / Q000235:genetics* / Q000276:immunology; D012486:Salmonella typhimurium