Thermal, ventilatory, and gluco-regulatory responses during exercise following short-term acetylsalicylic acid ingestion.
Acetylsalicylic acid and exercise combined produce perturbations in thermal, respiratory and carbohydrate metabolism. However, the therapeutic implications of these therapies are antithrombotic and fibrinolytic respectively. In a double-blind, counterbalanced cross-over design of eight men, salicylate ingestion in combination with 60 min of moderate intensity exercise (50% VO2 max) significantly increased respiratory rate and oxygen consumption (p less than 0.05) both at rest and during the exercise protocol. The effect of acetylsalicylic acid ingestion on gluco-regulatory and counter-regulatory hormones was not significant compared to the placebo. These data suggest a safe prophylactic role for a combined short-term acetylsalicylic acid ingestion and exercise therapy in the development of coronary artery disease when exercising in a thermal neutral environment.
De Meersman
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Applied Physiology Laboratory, Teachers College, Columbia University, New York, NY 10027.
D000328:Adult; D001241:Aspirin / Q000494:pharmacology* / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism*; D001833:Body Temperature Regulation / Q000187:drug effects*; D004311:Double-Blind Method; D005934:Glucagon / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D005082:Physical Exertion; D010919:Placebos; D012007:Rectum; D012119:Respiration / Q000187:drug effects*; D012881:Skin Temperature / Q000187:drug effects
D001786:Blood Glucose; D007328:Insulin; D010919:Placebos; D005934:Glucagon; D001241:Aspirin