Carbon tetrachloride modulates the rat hepatic microsomal UDP-glucuronyl transferase activity and membrane fluidity.
Modulations in rat hepatic microsomal UDP-glucuronyl transferase activity have been observed during carbon tetrachloride (CCl4) poisoning, with a large decrease in the enzyme cooperatively and increase in the membrane fluidity, occurring 30 min after administration. The results strengthen the possibility that an increase in microsomal membrane fluidity may be an early key event in liver injury induced by CCl4.
Deliconstantinos
G
G
Mykoniatis
M
M
Papadimitriou
D
D
D000494:Allosteric Regulation; D000818:Animals; D001663:Bilirubin / Q000494:pharmacology; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D005454:Fluorescence Polarization; D014453:Glucuronosyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007425:Intracellular Membranes / Q000502:physiology; D007700:Kinetics; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D008862:Microsomes, Liver / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D002251:Carbon Tetrachloride; D014453:Glucuronosyltransferase; D001663:Bilirubin