Multiple sclerosis and the evolution of growth hormone mechanisms in man.
This paper develops the hypothesis that a growth hormone-like substance and/or its receptor is the initial target of auto-antibodies in multiple sclerosis (MS). Regulatory mechanisms for hormone secretion may also be involved in the pathogenesis of MS. Demyelination may be subsequent (1) to an initial lesion to the anterior pituitary.
Fischer
K
K
Graduate School of Education, Univ. of Pennsylvania, Phila. 19104.
D005075:Biological Evolution; D002980:Climate; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D013472:Sunlight / Q000009:adverse effects
D013006:Growth Hormone