[Double-blind clinical study of the treatment of melasma with azelaic acid versus hydroquinone].
A comparative double-blind study was carried out on sixty patients received oral contraceptives. Patients were treated with 20% azelaic acid or 4% hydroquinone. They were observed for 24 weeks and the results compared and checked for side effects. The results showed that the azelaic acid was not better than the hydroquinone in the treatment of melasma but it could be used as alternative drug.
Piquero Martín
J
J
Instituto de Biomedicina, Caracas, Venezuela.
Rothe de Arocha
J
J
Beniamini Loker
D
D
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003998:Dicarboxylic Acids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006873:Hydroquinones / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008548:Melanosis / Q000188:drug therapy*; D009824:Ointments
D000970:Antineoplastic Agents; D003998:Dicarboxylic Acids; D006873:Hydroquinones; D009824:Ointments; C010038:azelaic acid
Estudio clínico doble ciego en el tratamiento del melasma entre ácido azelaico versus hidroquinona.