title: Myoelectric activity of the small bowel in mechanical obstruction and intra-abdominal bacterial contamination.
abstract: The myoelectric activity of the small bowel was evaluated in 6 rabbits following 24 h of complete small-bowel obstruction and in 6 rabbits during an intra-abdominal perfusion with a bacterial suspension containing Bacteroides fragilis and Escherichia coli. Myoelectric recordings were performed before and during pharmacological small-bowel stimulation with ceruletide. Following small-bowel obstruction both slow-wave frequency and spike activity were reduced. Ceruletide stimulation demonstrated a significantly decreased spike activity after 24 h of obstruction. Intra-abdominal bacterial contamination did not affect spontaneous slow-wave frequency and spike activity but induced complete resistance to ceruletide stimulation. Pharmacological stimulation is recommended as an additional method to evaluate the impairment of myoelectric activity in motility disorders.
authors.affiliation: Department of Surgery, University of Freiburg, FRG.
authors.forename: M
authors.initials: M
authors.lastname: Lausen
authors.forename: D
authors.initials: D
authors.lastname: Reichenbacher
authors.forename: G
authors.initials: G
authors.lastname: Ruf
authors.forename: U
authors.initials: U
authors.lastname: Schöffel
authors.forename: K
authors.initials: K
authors.lastname: Pelz
mesh_terms: D000005:Abdomen / Q000382:microbiology*; D000818:Animals; D001419:Bacteria; D001441:Bacteroides fragilis; D002108:Ceruletide / Q000494:pharmacology; D004576:Electromyography; D004926:Escherichia coli; D005260:Female; D007267:Injections; D007415:Intestinal Obstruction / Q000503:physiopathology*; D007421:Intestine, Small / Q000503:physiopathology*; D008297:Male; D009130:Muscle, Smooth / Q000503:physiopathology*; D010477:Perfusion; D011817:Rabbits; D012965:Sodium Chloride
chemical_list: D012965:Sodium Chloride; D002108:Ceruletide