Lectin Ulex europaeus agglutinin I specifically labels a subset of primary afferent fibers which project selectively to the superficial dorsal horn of the spinal cord.
To examine differential carbohydrate expression among different subsets of primary afferent fibers, several fluorescein-isothiocyanate conjugated lectins were used in a histochemical study of the dorsal root ganglion (DRG) and spinal cord of the rabbit. The lectin Ulex europaeus agglutinin I specifically labeled a subset of DRG cells and primary afferent fibers which projected to the superficial laminae of the dorsal horn. These results suggest that specific carbohydrates containing L-fucosyl residue is expressed selectively in small diameter primary afferent fibers which subserve nociception or thermoception.
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D000818:Animals; D050260:Carbohydrate Metabolism; D016650:Fluorescein-5-isothiocyanate; D005452:Fluoresceins; D005727:Ganglia, Spinal / Q000378:metabolism*; D006651:Histocytochemistry; D037102:Lectins; D009475:Neurons, Afferent / Q000378:metabolism; D009619:Nociceptors / Q000378:metabolism; D037121:Plant Lectins; D011817:Rabbits; D013116:Spinal Cord / Q000378:metabolism*; D013861:Thiocyanates
D005452:Fluoresceins; D037102:Lectins; D037121:Plant Lectins; D013861:Thiocyanates; C036850:Ulex europaeus lectins; D016650:Fluorescein-5-isothiocyanate