Potential carcinogenicity of aza-aromatic hydrocarbons: azabenz(a)anthracenes.
The potential carcinogenicity of 3 azabenz(a)anthracenes was determined in vitro. The 3 compounds tested were 1-, 2-, and 9-azabenz(a)anthracene. The initial assay was chemical carcinogen-induced enhancement of anchorage-independent survival of Rauscher leukemia virus-infected Fischer rat embryo cells, 2FR(4)50 (2FR4). Cells treated with 2- and 9-azabenz(a)anthracene showed dose-dependent increased survival. After continued subculturing, the surviving cells from 2- and 9-azabenz(a)anthracene-treated cultures displayed morphological transformation and ability to grow in semi-solid medium. Mock-treated controls and I-azabenz(a)anthracene-treated cultures did not show either of these properties. These data suggest that certain azabenz(a)anthracenes are potential carcinogens.
Miao
R M
RM
Tanga
M J
MJ
Suk
W A
WA
Miller
A
A
Reist
E J
EJ
D015112:4-Nitroquinoline-1-oxide; D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001372:Aza Compounds / Q000633:toxicity*; D001551:Benz(a)Anthracenes / Q000633:toxicity*; D002273:Carcinogens; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002478:Cells, Cultured; D051381:Rats
D001372:Aza Compounds; D001551:Benz(a)Anthracenes; D002273:Carcinogens; D015112:4-Nitroquinoline-1-oxide; D015127:9,10-Dimethyl-1,2-benzanthracene