title: Spatial regulation of Antennapedia and bithorax gene expression by the Polycomb locus in Drosophila.
abstract: Transcripts encoded by six of the homeotic lethal complementation groups within the Antennapedia and bithorax gene complexes (ANT-C and BX-C) accumulate primarily in nonoverlapping regions of the embryonic central nervous system (CNS). It has been previously proposed that the maintenance of these selective patterns of expression involve hierarchical cross-regulatory interactions among ANT-C and BX-C loci. Selective expression of the ANT-C and BX-C also involves regulation by a number of unlinked genetic loci, including the Polycomb (Pc) locus. Here we show that the ANT-C and BX-C transcript distribution patterns are dramatically altered in the CNS of Pc- embryos. We discuss these altered patterns of expression in the context of different models for the spatial regulation of ANT-C and BX-C gene expression.
authors.forename: C
authors.initials: C
authors.lastname: Wedeen
authors.forename: K
authors.initials: K
authors.lastname: Harding
authors.forename: M
authors.initials: M
authors.lastname: Levine
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000196:embryology / Q000502:physiology; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics*; D005786:Gene Expression Regulation; D005804:Genes, Lethal; D009024:Morphogenesis; D012333:RNA, Messenger / Q000235:genetics; D013909:Thorax
chemical_list: D012333:RNA, Messenger