title: The molecular genetics of complex inherited diseases.
abstract: The majority of inherited diseases are due to unknown biochemical defects, or are either polygenetic or multifactorial. Due to advances in molecular genetics, it is now possible to study these conditions, either by reverse genetics (using cloning techniques to move from linkage to gene, and then determining the protein involved) or by dissecting a complex disease into a set of monogenic paradigms.
authors.affiliation: Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, University of London, Norfolk, UK.
authors.forename: R
authors.initials: R
authors.lastname: Williamson
mesh_terms: D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005796:Genes; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D008040:Genetic Linkage; D005821:Genetic Techniques; D006801:Humans; D009154:Mutation
chemical_list: D004247:DNA