title: [Transabdominal choriocentesis for rapid prenatal diagnosis in the 2d trimester: experiences in 147 pregnant patients].
abstract: The simple technique of ultrasound guided transabdominal choriocentesis allows rapid karyotyping early in the second trimester. Choriocentesis was carried out in 147 pregnancies at (genetic) risk during the 13th-19th week of gestation. Results of reliable karyotyping were available within 2-4 days. In 146 (99.3%) women a sufficient amount of chorionic villi could be collected with maximal two needle insertions. An abnormal karyotype was found in four pregnancies, which were terminated selectively on parental request. In all pregnancies a follow-up by ultrasound was performed 4 weeks after the procedure, one (0.7%) unexplained fetal death occurred, 143 pregnancies remained uneventful. We concluded that transabdominal choriocentesis is a simple rapid and relatively safe method, which can be useful for rapid karyotyping during the second trimester.
authors.affiliation: Institut für Geburtshilfe und Frauenheilkunde, Universitätskrankenhaus, Niederlande.
authors.forename: M G
authors.initials: MG
authors.lastname: Jahoda
authors.forename: L
authors.initials: L
authors.lastname: Pijpers
authors.forename: A
authors.initials: A
authors.lastname: Reuss
authors.forename: E S
authors.initials: ES
authors.lastname: Sachs
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D002824:Chorionic Villi / Q000473:pathology*; D002869:Chromosome Aberrations / Q000175:diagnosis* / Q000235:genetics; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis / Q000379:methods*; D012307:Risk Factors; D014463:Ultrasonography
vernacular_title: Transabdominale Choriozentese für die schnelle pränatale Diagnostik im zweiten Trimenon: Erfahrungen bei 147 Schwangeren.