Calcium antagonists as a peripherally acting labyrinthine suppressant in humans.
A total of 908 patients with peripheral vestibular disorders were treated with calcium antagonists for periods of 10 to 120 days in a series of controlled clinical trials using a placebo or other medication for comparison. The cumulative analysis of the results indicates that cinnarizine, flunarizine and bencyclan have produced good clinical results, particularly in patients with vascular problems. A comparison between different doses used in different trials revealed a correlation of good clinical results to smaller doses of some of these medications.
Mangabeira-Albernaz
P L
PL
Department of Otolaryngology, Escola Paulista de Medicina, São Paulo, Brazil.
D001537:Bencyclane / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D002936:Cinnarizine / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005444:Flunarizine / Q000627:therapeutic use; D006801:Humans; D007759:Labyrinth Diseases / Q000188:drug therapy; D014722:Vestibule, Labyrinth
D002121:Calcium Channel Blockers; D002936:Cinnarizine; D001537:Bencyclane; D005444:Flunarizine