title: Fenticonazole tissue levels after the application of 3 different dosage forms of vaginal ovules.
abstract: Fenticonazole vaginal ovules of 200 mg, 600 mg and 1,000 mg were administered to 42 women prior to gynecological surgery. Tissue concentrations in the vaginal mucosa were determined after 3 h and 12 h in biopsy specimens taken from the same position in the posterior fornix. Tissue concentrations were higher at 3 h in comparison to 12 h with all 3 doses. There was no statistical difference between the concentrations yielded by the 3 different ovules at 3 h, while after 12 h the concentrations were dose-dependent and significantly higher after 1,000 mg in comparison to 200 mg, but not to 600 mg.
authors.affiliation: Institute of Clinical Obstetrics and Gynecology, University of Genova, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Gorlero
authors.forename: A
authors.initials: A
authors.lastname: Sartani
authors.forename: C I
authors.initials: CI
authors.lastname: Cordaro
authors.forename: D
authors.initials: D
authors.lastname: Bertin
authors.forename: C
authors.initials: C
authors.lastname: Reschiotto
authors.forename: L
authors.initials: L
authors.lastname: De Cecco
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011897:Random Allocation; D014621:Vagina / Q000378:metabolism
chemical_list: D007093:Imidazoles; C033486:fenticonazole