Generation of leukotrienes from fetal and neonatal porcine blood vessels.
Various blood vessels from fetal and neonatal piglets were challenged with calcium ionophore A23187, to examine the release of leukotriene-like material. All tissues released as much or more leukotriene (LT) than adult porcine tissues previously examined. The release fell with increasing gestational age. The release from the intra-abdominal umbilical vein at 11 days preterm (480 ng of LTD4-like activity per gram of tissue) was an order of magnitude higher than that previously observed. The implications with regard to control of the fetal circulatory pattern are discussed.
Piper
P J
PJ
Levene
S
S
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001808:Blood Vessels / Q000187:drug effects / Q000378:metabolism*; D000001:Calcimycin / Q000494:pharmacology; D005333:Fetus / Q000378:metabolism*; D066298:In Vitro Techniques; D013189:SRS-A / Q000096:biosynthesis*; D013552:Swine
D013189:SRS-A; D000001:Calcimycin