title: Invited contribution: an objective approach to the development of short-term tests predictive of carcinogenicity.
abstract: The Carcinogenicity Prediction and Battery Selection procedure was developed to address two problems: (1) the identification of highly predictive, yet cost-effective, batteries of short-term tests and (2) the objective prediction of the potential carcinogenicity of chemicals based upon the results of short-term tests even when a mixture of positive and negative results is obtained. In the present report the usefulness of the Carcinogenicity Prediction and Battery Selection procedure is demonstrated using benzo[a]pyrene, benzoin and diethylstilbestrol as examples. In addition, its applicability in the analysis of all the possible outcomes of a battery is illustrated together with an analysis of the worth of additional testing.
authors.affiliation: Department of Environmental Health Sciences, Case Western Reserve University, Cleveland, Ohio 44106.
authors.forename: H S
authors.initials: HS
authors.lastname: Rosenkranz
authors.forename: F K
authors.initials: FK
authors.lastname: Ennever
authors.forename: V
authors.initials: V
authors.lastname: Chankong
authors.forename: J
authors.initials: J
authors.lastname: Pet-Edwards
authors.forename: Y Y
authors.initials: YY
authors.lastname: Haimes
mesh_terms: D000818:Animals; D015197:Carcinogenicity Tests / Q000379:methods*; D002273:Carcinogens / Q000633:toxicity*; D004054:Diethylstilbestrol / Q000633:toxicity*; D006801:Humans; D011237:Predictive Value of Tests
chemical_list: D002273:Carcinogens; D004054:Diethylstilbestrol