Extracorporeal CO2 Removal in severe adult respiratory distress syndrome.
Sixty-five per cent survival has been achieved in a group of patients with severe ARDS and a predicted mortality of 92%, by the use of Gattinoni's technique of extracorporeal CO2 removal. In patients and animals the technique has usually resulted in rapid improvement in the radiographic appearance and lung function. There are several possible mechanisms by which the technique may facilitate lung repair, including improvement of lung tissue oxygenation, the avoidance of high airway pressures and regional alkalosis in the lung, a reduction in oxygen toxicity, and the frequency observed reduction in pulmonary artery pressure. The apparent effectiveness of the technique and other associated evidence have implications which should lead us to reconsider some aspects of our conventional management of patients with severe ARDS.
Hickling
K G
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D000472:Alkalosis, Respiratory / Q000517:prevention & control; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood*; D005112:Extracorporeal Circulation; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007511:Ischemia / Q000517:prevention & control; D008168:Lung / Q000098:blood supply; D008722:Methods; D010107:Oxygenators, Membrane; D011175:Positive-Pressure Respiration; D011312:Pressure; D011651:Pulmonary Artery / Q000503:physiopathology; D011658:Pulmonary Fibrosis / Q000209:etiology; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000628:therapy*; D014692:Ventilation-Perfusion Ratio
D002245:Carbon Dioxide; D006493:Heparin