title: [Laryngeal cancer in immunosuppressive therapy with cyclosporin A].
abstract: As a serious side effect of immunosuppressive therapy following organ transplantation, the incidence of malignancies shows a significant threefold increase compared with the age-matched general population. Under treatment with conventional immunosuppressive drugs (azathioprine, steroids and antilymphocyte globulin) patients are supposed to be susceptible to skin and lip cancers (40%) whereas the recently introduced new immunosuppressive drug cyclosporine A shows a comparable incidence of non-Hodgkin lymphomas (41%) and the patients seem to develop more potentially life threatening tumours of internal organs. In the present paper we report on a case of laryngeal carcinoma following immunosuppressive treatment with cyclosporine A 10 months after heart transplantation.
authors.affiliation: HNO-Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
authors.forename: S
authors.initials: S
authors.lastname: Ballhaus
authors.forename: G
authors.initials: G
authors.lastname: Grevers
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000601:surgery; D002311:Cardiomyopathy, Dilated / Q000601:surgery*; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects*; D016027:Heart Transplantation; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D007822:Laryngeal Neoplasms / Q000139:chemically induced* / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D011183:Postoperative Complications / Q000601:surgery
chemical_list: D003524:Cyclosporins
vernacular_title: Larynxkarzinom unter immunsuppressiver Therapie mit Cyclosporin A.