Protective effects of corticosteroids in contrast material anaphylaxis.
A prospective, randomized study of the potential protective effects of corticosteroids administered as pretreatment against contrast material (CM) reactions is reported. Patients (n = 6,763) from multiple institutions received either a single dose of steroids (32 mg of oral methylprednisolone, approximately 2 hours before CM challenge), a double dose (32 mg approximately 12 hours and 2 hours before CM challenge), or placebo. All contrast injections were with ionic media and were given intravenously. The two-dose (but not the one-dose) corticosteroid regimen provided significant protection. The effect on reaction incidences of a number of historical variables is also tabulated.
Lasser
E C
EC
Department of Radiology, UCSD School of Medicine, La Jolla 92093-0632.
Berry
C C
CC
Talner
L B
LB
Santini
L C
LC
Lang
E K
EK
Gerber
F H
FH
Stolberg
H O
HO
D000707:Anaphylaxis / Q000517:prevention & control*; D003287:Contrast Media / Q000009:adverse effects*; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use*; D015337:Multicenter Studies as Topic; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation
D003287:Contrast Media; D008775:Methylprednisolone