Focal-segmental glomerulosclerosis associated with herpes simplex viral encephalitis.
A 5-month-old boy presented nephrotic syndrome associated with severe viral encephalitis. From his various body fluids herpes simplex virus (HSV) type 1 and anti-HSV antibodies could be isolated. Renal biopsy showed focal-segmental glomerulosclerosis and cytomegaly within the mesangial region in a single glomerulus. Immunohistology demonstrated mesangial and segmental depositions of IgM and C3. HSV antigen could be detected in two of the glomeruli. Osmiophilic mesangial deposits, segmental sclerosis and foot process fusion of podocytes could be seen by electron microscopy. In the nucleoplasm of a mesangial cell of a single glomerulus typical viral particles were observed. To the best of the author's knowledge this is the first reported case in the literature on human herpes glomerulopathy confirmed by histological examination.
Tóth
T
T
Department of Pathology, Szolnok County Hospital, Hungary.
Szücs
S
S
D004660:Encephalitis / Q000209:etiology*; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000209:etiology*; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology* / Q000473:pathology; D006561:Herpes Simplex / Q000473:pathology*; D006801:Humans; D007223:Infant; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male