Surface modification for improved blood compatibility.
Several surface modification techniques are currently being used to improve the biocompatibility of blood-contacting devices. These include the immobilization of bioactive materials to prevent thrombus generation and platelet activation, the incorporation of hydrophilic grafts onto practical hydrophobic surfaces (polyurethanes) to reduce protein adsorption, and the concept of microdomain-phase separated surfaces to regulate cellular and protein adhesion.
Jacobs
H
H
Department of Pharmaceutics, University of Utah, Salt Lake City 84108.
Grainger
D
D
Okano
T
T
Kim
S W
SW
D000818:Animals; D001672:Biocompatible Materials; D001769:Blood; D006801:Humans; D011108:Polymers; D013499:Surface Properties; D013927:Thrombosis / Q000517:prevention & control*
D001672:Biocompatible Materials; D011108:Polymers