title: Treatment of various forms of bovine mastitis with consideration of udder pathology and the pharmacokinetics of appropriate drugs: a review.
abstract: Various forms of clinical and subclinical mastitis occur in the bovine, and intramammary therapy alone or in combination with parenteral therapy must be implemented with due consideration of udder pathology and the pharmacokinetic properties of drugs used for the treatment of mastitis. Supportive therapy for cows with acute or peracute mastitis and optimal animal husbandry are of the utmost importance for a relatively good prognosis. The withholding period of milk for human consumption after the last intramammary antibiotic treatment as well as minimum intervals between antibiotic dry cow treatment and calving are given. The main reasons for mastitis therapy failure are udder pathology caused by the inflammatory process, the pharmacokinetic properties of mastitis drugs under those conditions, inadequate supportive therapy and poor animal husbandry.
authors.affiliation: Department of Veterinary Public Health, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Republic of South Africa.
authors.forename: J H
authors.initials: JH
authors.lastname: du Preez
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics; D002417:Cattle; D005260:Female; D008414:Mastitis, Bovine / Q000145:classification / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents