[Two cases of Kallmann's syndrome].
Herein we report two cases of hypogonadism with anosmia or hyposmia (Kallmann's syndrome), a 23-year-old single man (case 1) and a 34-year-old single man. (case 2). Micropenis and small testes were seen in both cases. Central anosima and central hyposmia were found in cases 1 and 2, respectively. Their karyotypes were normal (46, XY). The plasma levels of LH and FSH were low and the reaction to LH-RH test was poor in both cases. After repetitious LH-RH administrations, a good response of plasma LH was recognized in both cases except for a poor response of plasma FSH in case 1, while plasma testosterone remained low in both cases. Their testicular biopsies revealed immature testes without any developed Sertoli and Leydig cells.
Kondo
F
F
Fujii
H
H
Okamura
K
K
Tokunaka
S
S
Takamura
T
T
Yachiku
S
S
D000328:Adult; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D000857:Olfaction Disorders / Q000175:diagnosis*; D013577:Syndrome
D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone