Cytoprotective effect of free radical scavengers against mucosal damage produced by different antirheumatic drugs.
Following 200 mg aspirin, 20 mg indomethacin or 100 mg diclofenac, gastric mucosal damage was evoked after five hours in rats. By administering vitamin A, vitamin E, MTDQ (6,6-methylenebis-2,2,4-trimethyl-1,2-dihydroquinoline), vitamin C, lipoic acid and penicillamine intragastrically at the time of the application of the damaging agent, the authors studied the beneficial effect of these free-radical scavengers upon the mucosal lesions. Vitamin C and penicillamine exerted no significant protective effect. Among the other drugs, the most effective were the lipid-soluble ones: vitamin A, vitamin E and MTDQ. The authors hypothesized that the gastric damage may be connected with the degradation of the polyunsaturated fatty acid components of the cellular membranes and thus the lipid-soluble free radical scavengers were able to offer protection.
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D000818:Animals; D000893:Anti-Inflammatory Agents / Q000037:antagonists & inhibitors*; D000897:Anti-Ulcer Agents; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001241:Aspirin / Q000037:antagonists & inhibitors; D004008:Diclofenac / Q000037:antagonists & inhibitors; D005260:Female; D005609:Free Radicals; D005753:Gastric Mucosa / Q000187:drug effects*; D007213:Indomethacin / Q000037:antagonists & inhibitors; D008297:Male; D010396:Penicillamine / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D012995:Solubility; D008063:Thioctic Acid / Q000494:pharmacology; D014801:Vitamin A / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D000975:Antioxidants; D005609:Free Radicals; D011804:Quinolines; D014801:Vitamin A; D014810:Vitamin E; D004008:Diclofenac; C011923:6,6'-methylene bis(2,2,4-trimethyl-1,2-dihydroquinoline); D008063:Thioctic Acid; D010396:Penicillamine; D001205:Ascorbic Acid; D001241:Aspirin; D007213:Indomethacin