title: Catalase inhibition by sulfide and hydrogen peroxide-induced mutagenicity in Salmonella typhimurium strain TA102.
abstract: The lethal and mutagenic effects of hydrogen peroxide were studied in exponentially growing cultures of Salmonella typhimurium strain TA102. Exposure of the cultures to non-lethal levels of sodium sulfide significantly increased the lethality and mutagenicity of hydrogen peroxide. The catalase activity was decreased in cells exposed to sodium sulfide, but there were no changes in the cellular levels of superoxide dismutase, glutathione reductase, or NADPH-dependent alkyl hydroperoxide reductase. Hydrogen peroxide-induced mutagenesis and killing of S. typhimurium strain TA102 in the presence of sulfide may in part be explained by an inactivation of catalase by sulfide.
authors.affiliation: Department of Oral Microbiology, University of Umeå, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Carlsson
authors.forename: E H
authors.initials: EH
authors.lastname: Berglin
authors.forename: R
authors.initials: R
authors.lastname: Claesson
authors.forename: M B
authors.initials: MB
authors.lastname: Edlund
authors.forename: S
authors.initials: S
authors.lastname: Persson
mesh_terms: D002374:Catalase / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D005980:Glutathione Reductase / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000633:toxicity*; D009154:Mutation / Q000187:drug effects*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000201:enzymology; D013440:Sulfides / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D013440:Sulfides; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; C033479:sodium sulfide