title: Current perspectives on the epidemiology and pathogenesis of clinically significant Vibrio spp.
abstract: Recent taxonomic advances have now implicated several different Vibrio species as human pathogens. While the most common clinical presentation of Vibrio infection continues to be gastroenteritis, an increasing number of extraintestinal infections are being reported, particularly in immunocompromised individuals. Detection of Vibrio infections requires a good clinical history and the use of appropriate isolation and identification procedures by the laboratory to confirm illnesses attributed to Vibrio species. Except for Vibrio cholerae O1 and Vibrio parahaemolyticus, there is little direct evidence linking the production of a myriad of cell-associated or extracellular factors produced by each species with human disease and pathogenesis. Many questions regarding pathogenic Vibrio species remain unanswered, including their frequency and distribution in environmental specimens (water, shellfish), infective doses, virulence potential of individual isolates, and markers associated with such strains.
authors.affiliation: Microbial Diseases Laboratory, California Department of Health Services, Berkeley 94704.
authors.forename: J M
authors.initials: JM
authors.lastname: Janda
authors.forename: C
authors.initials: C
authors.lastname: Powers
authors.forename: R G
authors.initials: RG
authors.lastname: Bryant
authors.forename: S L
authors.initials: SL
authors.lastname: Abbott
mesh_terms: D004812:Epidemiologic Methods; D006801:Humans; D014481:United States; D014733:Vibrio / Q000145:classification / Q000472:pathogenicity; D014735:Vibrio Infections / Q000453:epidemiology* / Q000209:etiology; D014774:Virulence