title: Chemical stabilities of cefoperazone sodium and ceftazidime in 5% dextrose and 0.9% sodium chloride injections.
abstract: The chemical stabilities of cefoperazone and ceftazidime solutions in 5% dextrose and 0.9% sodium chloride injections have been studied using high-performance liquid chromatography methods. The solutions of cefoperazone were stable for 8 days (loss in potency of less than 10%) at 25 degrees C, for at least 80 days at 5 degrees C and for at least 96 days at -10 degrees C. The ceftazidime solutions were stable for only 2 days at 25 degrees C, for 21 days at 5 degrees C (28 days in normal saline) and for 90 days at -10 degrees C. Thawing the frozen solutions using a microwave oven did not cause degradation.
authors.affiliation: Department of Pharmaceutics, University of Houston, TX 77030.
authors.forename: V
authors.initials: V
authors.lastname: Das Gupta
authors.forename: C
authors.initials: C
authors.lastname: Bethea
authors.forename: M
authors.initials: M
authors.lastname: dela Torre
mesh_terms: D002438:Cefoperazone; D002442:Ceftazidime; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D005947:Glucose; D006863:Hydrogen-Ion Concentration; D007267:Injections; D012965:Sodium Chloride; D012996:Solutions
chemical_list: D012996:Solutions; D012965:Sodium Chloride; D002438:Cefoperazone; D002442:Ceftazidime; D005947:Glucose