title: Monotherapy and combined treatment with captopril.
abstract: The effectiveness of captopril, the dose-response relationships, the influence of diuretics on the effective dose of captopril, the possible combinations of captopril with other antihypertensive agents as well as the clinical value of monotherapy and combined treatment have been investigated in 48 patients with hypertension. This paper summarizes the data obtained in the course of several special clinico-pharmacological studies during a 4 year period (1982-1986). Captopril proved to be an antihypertensive agent with a wide therapeutic spectrum. As a single agent it was used especially in geriatric cases. Of the antihypertensive agents, diuretics have been combined with captopril most frequently but it has been concurrently administered with practically all the other antihypertensive drugs. Captopril appeared to be a safe agent without significant side effects. An increase in serum potassium levels by captopril were seen not infrequently; its advantages, disadvantages, prevention and mechanisms have been dealt with in detail.
authors.affiliation: Third Department of Internal Medicine, Weil Emil Hospital, Budapest, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Radó
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002216:Captopril / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004487:Edema / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008103:Liver Cirrhosis / Q000188:drug therapy
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D002216:Captopril