[Occurrence of spontaneous and nitrosoethylurea-induced mutations and potential changes in repair-deficient Drosophila strains].
X-linked recessive lethal frequencies in mature spermatozoa were studied in repair-deficient Drosophila strains. Frequencies of spontaneous and ethylnitrosourea-induced lethals were enhanced in mus(I)104DI+ and unchanged in mei-9IL+. In addition, the majority of lethals was fixed in stages preceding mature spermatozoa. It was shown that premutational lesions (spontaneous and ethylnitrosourea-induced in both mutants) arise in germ cells, these lesions being realized into mutations in the next generations.
Aslanian
M M
MM
Kim
A I
AI
Mageramova
L M
LM
D000818:Animals; D004260:DNA Repair; D004331:Drosophila melanogaster / Q000235:genetics*; D005038:Ethylnitrosourea; D005260:Female; D005787:Gene Frequency; D005804:Genes, Lethal; D005808:Genes, Recessive; D008040:Genetic Linkage; D008297:Male; D009154:Mutation; D014960:X Chromosome
D005038:Ethylnitrosourea
Vozniknovenie spontannykh i indutsirovannykh nitrozoétilmochevinoĭ mutatsiĭ i potentsial'nykh izmeneniĭ v liniiakh drozofily s narushennoĭ reparatsieĭ.