Alcohol-related symptoms in heterogeneous families of hospitalized alcoholics.
Heterogeneity in the clinical symptoms of alcohol abuse was examined in 243 men and 305 women from families of hospitalized alcoholics, who had demonstrated different patterns of inheritance of susceptibility to alcoholism. Discriminant analysis was utilized to identify nine alcoholic symptoms that distinguished male relatives of alcoholic men from those of alcoholic women. Inability to abstain from alcohol, fighting and reckless driving while intoxicated, and alcohol treatment other than Alcoholics Anonymous were more prevalent in families of male probands. Male relatives of female probands experienced later onset of loss of control over drinking associated with benders, and cirrhosis and feelings of guilt. Female relatives of alcoholic men and women showed a marked predominance of the latter (Type 1) features, whereas male relatives had different clinical features, depending on the associated mode of inheritance.
Gilligan
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SB
Division of Biological and Biomedical Sciences, Washington University.
Reich
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T
Cloninger
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CR
D000328:Adult; D000437:Alcoholism / Q000235:genetics* / Q000523:psychology; D005260:Female; D005787:Gene Frequency; D006580:Genetic Carrier Screening; D006801:Humans; D008297:Male; D010641:Phenotype; D012307:Risk Factors; D012737:Sex Factors