Superior prevention of reinfarction by 30 mg/d aspirin compared with 1000 mg/d: results of a two years follow-up study in Cottbus.
In a two years reinfarction study including all patients suffering from myocardial infarction in the district of Cottbus (900000 inhabitants) between the 1.1.1981 and 31.8.1983 (totally 701 patients) we found a statistically significant lower rate of reinfarctions, in patients over 60 years also of the total mortality treated with 30 mg aspirin per day compared with 1000 mg per day. A statistically significant superiority of the 30 mg aspirin dosage compared with the 1000 mg dosage was found in patients aged over 50 years, in male patients, in patients with angina pectoris in their anamnesis, in patients with ST-depression of greater than 0.5 mm 2 weeks after the cardiac event, in patients with all kinds of infarct localization except posterior myocardial infarction and in patients with hypercholesterolaemia (greater than = 7.3 mmol/l).
Förster
W
W
Department of Pharmacology and Toxicology Martin Luther-University Halle-Wittenberg, GDR.
Hoffmann
W
W
D000368:Aged; D001241:Aspirin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality / Q000517:prevention & control; D012008:Recurrence
D001241:Aspirin