title: Cancer of the pancreas and periampullary region--diagnosis and surgical therapy.
abstract: Carcinoma of the periampullary region continues to be a challenging problem. The incidence of these tumours, especially adenocarcinoma of the pancreas, has increased steadily over the last 20 years. In spite of better diagnostic techniques, the long-term survival for patients with these tumours has remained relatively unchanged. Total pancreatectomy and regional pancreatectomy have not demonstrated a survival advantage superior to that of pancreatoduodenectomy. Especially for pancreatic carcinoma, earlier diagnosis and effective adjuvant therapy are necessary. Finally, local excision of small ampullary carcinomas in high-risk surgical patients offers survival rates comparable to those of a major resection.
authors.affiliation: Department of General Surgery, Cleveland Clinic Foundation, Ohio 44106.
authors.forename: D P
authors.initials: DP
authors.lastname: Vogt
authors.forename: R E
authors.initials: RE
authors.lastname: Hermann
mesh_terms: D014670:Ampulla of Vater; D003138:Common Bile Duct Neoplasms / Q000175:diagnosis / Q000601:surgery; D004379:Duodenal Neoplasms / Q000175:diagnosis / Q000601:surgery; D004386:Duodenum / Q000601:surgery; D006801:Humans; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000601:surgery