Metabolites of microorganisms. 247. Phenazines from Streptomyces antibioticus, strain Tü 2706.
From a strain of Streptomyces antibioticus seven yellow phenazines were isolated. The antibacterially most active antibiotic was identified as (-)-saphenamycin, a second one with compound DC-86-Y (saphenic acid). Three compounds were new: Saphenic acid methyl ether, 6-acetylphenazine-1-carboxylic acid and an inseparable mixture of fatty acid esters of saphenic acid. Two simple phenazines were phenazine-1-carboxylic acid (tubermycin B) and unsubstituted phenazine, which was isolated for the first time from a microorganism.
Geiger
A
A
Organisch-chemisches Laboratorium, Eidgenössische Technische Hochschule, Zürich, Switzerland.
Keller-Schierlein
W
W
Brandl
M
M
Zähner
H
H
D008826:Microbial Sensitivity Tests; D010619:Phenazines / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*; D013303:Streptomyces antibioticus / Q000378:metabolism*
D010619:Phenazines