title: Bromocriptine holiday: effects on dopamine receptors and turning behavior in rats.
abstract: In experimental Parkinson's disease, we studied the effects of chronic administration (30 days), withdrawal, and reinstitution of bromocriptine. Dopamine (DA) receptor supersensitivity was produced by 6-hydroxydopamine and reversed by chronic bromocriptine administration. Drug holiday reestablished sensitivity of DA receptors, but reinstitution of bromocriptine again downregulated receptors. The effects of a drug holiday on DA receptors are short-lived, and long-term clinical improvement cannot be expected. Apomorphine-induced contralateral turning produced by the lesion was unaffected by any drug regimen.
authors.forename: A M
authors.initials: AM
authors.lastname: Kenny
authors.forename: M B
authors.initials: MB
authors.lastname: Schneider
authors.forename: D R
authors.initials: DR
authors.lastname: Baden
authors.forename: R F
authors.initials: RF
authors.lastname: Pfeiffer
authors.forename: L C
authors.initials: LC
authors.lastname: Murrin
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001665:Binding Sites; D001971:Bromocriptine / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D004298:Dopamine / Q000378:metabolism; D004334:Drug Administration Schedule; D006892:Hydroxydopamines; D008297:Male; D016627:Oxidopamine; D010300:Parkinson Disease / Q000188:drug therapy*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra / Q000187:drug effects; D013997:Time Factors
chemical_list: D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D015102:3,4-Dihydroxyphenylacetic Acid; D001971:Bromocriptine; D016627:Oxidopamine; D004298:Dopamine