title: [Pseudotumoral lupus anetoderma. Child chorea. Development over 28 years].
abstract: The finding in a 40-year old and apparently healthy woman of a pseudotumoral lesion of the left arm which had gradually developed over a 9-year period led to a tentative clinical diagnosis of lupus anetoderma. This diagnosis was confirmed on the one hand by histological examination of the skin--which showed almost total disappearance of dermal elastic fibres, while the lympho-histiocytic infiltrate was so discreet that it excluded a deep lupus--and on the other hand by direct immunofluorescence, with lupus band on the lesion and a few abnormalities of the exposed and covered healthy skin. A history of chorea at the age of 13 years raised the problem of a possible relationship between this neurological disease and a systemic lupus erythematosus. This hypothesis was supported by resolutive episodes of arthralgia and abnormal laboratory findings, such as accelerated ESR, leucopenia, decrease of complement and presence of homogeneous antinuclear antibodies. Anticardiolipin antibodies, circulating anticoagulants and VDRL test were negative. Treatment with anti-malarials brought about some degree of cutaneous shrinkage and a significant decrease in ESR. This case is reported because anetoderma as sole manifestation of systemic lupus erythematosus and the occurrence, 17 years previously, of chorea are exceptional events.
authors.forename: L
authors.initials: L
authors.lastname: Schnitzler
authors.forename: P H
authors.initials: PH
authors.lastname: Abimelech
authors.forename: B
authors.initials: B
authors.lastname: Naveau
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001284:Atrophy; D001799:Blood Sedimentation; D002819:Chorea / Q000150:complications* / Q000473:pathology; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology
chemical_list: D000974:Antibodies, Antinuclear; D003165:Complement System Proteins
vernacular_title: Anétodermie lupique pseudo-tumorale. Chorée infantile. Evolution sur 28 ans.