The neural cell spectrin skeleton: a review.
The discovery of nonerythroid spectrin (Goodman et al., Proc. Natl. Acad. Sci. USA 78: 7570-7574, 1981) has generated interest equivalent to that occurring upon the identification of nonmuscle actin and myosin. Brain spectrin has become the best-studied member of the nonerythroid spectrin family of molecules. In this review, we discuss the structure and functional interactions of brain spectrin, as a prelude to attempting to resolve what are some of the more controversial questions in the field. We finish with a discussion of what may be the most profitable directions for future research.
Goodman
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SR
Zagon
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D000818:Animals; D001923:Brain Chemistry; D002845:Chromatography; D003599:Cytoskeleton / Q000648:ultrastructure*; D004586:Electrophoresis; D006801:Humans; D008565:Membrane Proteins / Q000302:isolation & purification / Q000502:physiology*; D008854:Microscopy, Electron; D008956:Models, Chemical; D009419:Nerve Tissue Proteins / Q000302:isolation & purification / Q000502:physiology*; D009474:Neurons / Q000032:analysis / Q000648:ultrastructure*; D010750:Phosphoproteins / Q000502:physiology; D013049:Spectrin / Q000502:physiology; D016704:Synapsins
D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; D016704:Synapsins; C041393:spectrin-like proteins; D013049:Spectrin