[Pharmacokinetics and tolerance of ceftriaxone after subcutaneous administration].
Having affirmed that a dose of 2 g ceftriaxone (CTRX) administered subcutaneously (SC) to healthy volunteers was well absorbed, the same dose administered to eight patients first intravenously (days 1 to 3), then SC (days 4 to 6). Plasma levels obtained after SC administration are similar to those obtained after IV administration and are consistent with drug therapeutic efficacy. The poor tolerance of CTRX when administered SC represents a very important limiting factor on the administration of a 2 g dose via this path.
Bricaire
F
F
Département de Pharmacologie clinique, Hôpital Claude-Bernard, Paris.
Castaing
J L
JL
Pocidalo
J J
JJ
Vilde
J L
JL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002443:Ceftriaxone / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D010146:Pain / Q000139:chemically induced
D002443:Ceftriaxone
Etude de la pharmacocinétique et de la tolérance de la ceftriaxone administrée par voie sous-cutanée.