title: Clinical management of cytotoxic drug overdose.
abstract: In this article the pharmacological management of accidental drug overdose is discussed, with various treatments for overdose proposed, as supported by clinical facts and speculation. Current knowledge is outlined concerning dacarbazine, nitrosourea compounds, melphalan, procarbazine, cyclophosphamide, VP-16.213, l-asparaginase (colaspase), 6-mercaptopurine, mustine (nitrogen mustard), intravenous or intrathecal methotrexate (amethopterin), cytarabine (cytosine arabinoside), fluorouracil and bleomycin.
authors.affiliation: Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: L L
authors.initials: LL
authors.lastname: Thomas
authors.forename: M J
authors.initials: MJ
authors.lastname: Mertens
authors.forename: A E
authors.initials: AE
authors.lastname: von dem Borne
authors.forename: C J
authors.initials: CJ
authors.lastname: van Boxtel
authors.forename: C H
authors.initials: CH
authors.lastname: Veenhof
authors.forename: E P
authors.initials: EP
authors.lastname: Veies
mesh_terms: D000970:Antineoplastic Agents / Q000506:poisoning*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents