Interactive effects on renal function between renal ischemia and intravascular contrast media.
This review deals with some recent animal and clinical investigations that show that small amounts of intravascular contrast media (CM) that remain in the body at the time of surgery and are the residual from a preoperative roentgen examination may increase (potentiate) the renal injury resulting from temporary intraoperative renal artery occlusion. Such interaction (potentiation) may occur in each of the following clinical situations: (1) aortorenal reconstructive surgery after angiography; (2) kidney harvesting after cerebral angiography in cadaver donors; and (3) percutaneous dilatation of a stenotic renal artery that includes a sequence of CM injections and balloon inflations that occlude the renal artery. It is concluded that such a potentiation may be decreased by prolonging the time interval between CM injection and the subsequent temporary renal arterial occlusion because such a prolongation decreases the amount of CM that remains in the kidney at time of occlusion.
Almén
T
T
Department of Experimental Research, Malmö General Hospital, University of Lund, Sweden.
Bergqvist
D
D
Cederholm
C
C
Golman
K
K
Husberg
B
B
Takolander
R
R
Weibull
H
H
D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D051381:Rats; D012078:Renal Artery Obstruction; D012079:Renal Circulation; D013997:Time Factors
D003287:Contrast Media