Defective synthesis of apolipoprotein A-I in jejunal mucosa in coeliac disease.
Apolipoprotein A-I was studied in biopsy specimens from the duodenojejunal junction by means of an indirect immunoperoxidase technique. In normal control subjects apolipoprotein A-I was immunohistochemically detected only in the absorptive cells at the tips of villi and was mainly localized supranuclearly. In 14 patients with coeliac disease apolipoprotein A-I was virtually undetectable. This implies that the inflammatory lesion in coeliac disease decreases the intestinal mass of apolipoprotein A-I, because it destroys the villous absorptive cells. Apolipoprotein A-I concentrations in plasma were also decreased (by 40%) in patients with coeliac disease, suggesting that the intestine has a role in maintaining plasma apolipoprotein A-I levels.
Florén
C H
CH
Dept. of Medicine, University Hospital, Lund, Sweden.
Alm
P
P
D000328:Adult; D000368:Aged; D001054:Apolipoproteins A / Q000096:biosynthesis* / Q000097:blood; D002446:Celiac Disease / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007413:Intestinal Mucosa / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D001054:Apolipoproteins A