[Immune-endocrine relations in obesity in children].
A total of 196 children aged 5 to 14 (156 of them with obesity, 40 healthy children) were investigated. The immune status of children with various clinicogenetic types of obesity was characterized by the reduction of the number of T-lymphocytes and their function, change in the ratio of T-lymphocyte subpopulations, an increase in the level of 0-lymphocytes, dysimmunoglobulinemia resulting from an increase in IgA concentration and a decrease in the IgG level, an increase in CIC concentration. Hyperinsulinemia and a rise of the blood level of C-peptide were revealed. Insulin inhibited rosette formation with sheep erythrocytes. A study of the effect of insulin on LBTR permitted a conclusion of insulin stimulation of immature lymphocytes and lymphocyte sensitization of obese children to insulin. Immune deviations were most probably determined by direct or metabolic-associated effects of insulin. The investigation opens up opportunities for the development of appropriate effective therapy.
Kravets
E B
EB
D000293:Adolescent; D002096:C-Peptide / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008214:Lymphocytes / Q000276:immunology; D009765:Obesity / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D012397:Rosette Formation
D002096:C-Peptide; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007328:Insulin
Immunoéndokrinnye vzaimosviazi pri ozhirenii u deteĭ.