Levels of insulin in the brains of rats modified by chronic administration of amphetamine, haloperidol and sulpiride.
Rats treated with two classic neuroleptic drugs at therapeutic doses, haloperidol (0.05 mg/kg/day i.p.) and sulpiride (3 mg/kg/day i.p.) showed a marked decline in cerebral levels of insulin (0.085 +/- 0.02 ng/g and 0.120 +/- 0.04 ng/g wet weight respectively) compared to the control group (0.383 +/- 0.05 ng/g wet weight), while rats given D-amphetamine bitartrate chronically (20 mg/kg/day p.o.) showed an increase in cerebral insulin (0.55 +/- 0.04 ng/g wet weight). Combining treatment with each neuroleptic drug and amphetamine, at the same doses, produced a significant decrease in cerebral levels of insulin (P less than 0.001) as in the amphetamine animals. In the groups of rats treated with haloperidol, sulpiride and both of these drugs combined with amphetamine, there was a slight increase in levels of serum insulin, more so in the neuroleptic groups. Serum glucose values did not vary.
Manzanares
J
J
Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, Spain.
Cantón
R
R
Grande
C
C
Benedí
J
J
Zaragozá
F
F
D000661:Amphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D013469:Sulpiride / Q000008:administration & dosage / Q000494:pharmacology*
D007328:Insulin; D011954:Receptors, Dopamine; D013469:Sulpiride; D000661:Amphetamine; D006220:Haloperidol