title: Pharmacological management of an impending placental insufficiency.
abstract: By means of drug administration a further decrease of the placental circulation in premature sonographic maturity of the placenta could be prevented via influencing the TXA2/PGI2 balance. Treatment of premature sonographic placental maturity with 50 mg acetylsalicylic acid (ASA) per day and three times daily 100 mg Rocornal, respectively, resulted in a significant increase of the birth weights. In a second series of experiments, three groups were treated with 50 mg/day ASA or 250 mg ASA/once per week and three times/day 100 mg Rocornal, respectively, from the 18th or 20th week of gestation to the 35th week. Subsequently, they were compared to a group of untreated controls. The birth weights of all treated groups were statistically significantly higher. The underlying mechanism is suggested to be an improved microcirculation.
authors.affiliation: Department of Gynaecology and Obstetrics of the District Hospital Merseburg, GDR.
authors.forename: H
authors.initials: H
authors.lastname: Köpernick
authors.forename: H J
authors.initials: HJ
authors.lastname: Mest
authors.forename: B
authors.initials: B
authors.lastname: Schwarz
mesh_terms: D001241:Aspirin / Q000627:therapeutic use; D011464:Epoprostenol / Q000032:analysis; D005260:Female; D005865:Gestational Age; D006801:Humans; D008833:Microcirculation / Q000187:drug effects; D010922:Placenta Diseases / Q000188:drug therapy*; D010927:Placental Insufficiency / Q000188:drug therapy*; D011247:Pregnancy; D013928:Thromboxane A2 / Q000032:analysis; D014192:Trapidil / Q000627:therapeutic use; D014465:Ultrasonics
chemical_list: D013928:Thromboxane A2; D011464:Epoprostenol; D014192:Trapidil; D001241:Aspirin