[Prostaglandin synthetase activity in the different layers of the kidneys of young rats exposed to polyene antibiotics].
Prostaglandin (PG)-synthestase activity was studied in the cortical, medullary and papillary kidney layers in young rats subjected to prolonged administration of polyene antibiotics (amphotericin B, levorin and nystatin). This activity was markedly increased during the first few hours after the administration of amphotericin B. At later terms a pronounced decline in the enzyme activity was observed. The changes were most prominent in the medullary and papillary layers. The other two antibiotics were less potent. The experimental results have shown that amphotericin B had maximal effect on renal PG-synthetase activity, while the sodium salt of nystatin was least effective.
Efendiev
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D000666:Amphotericin B / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D002174:Candicidin / Q000633:toxicity; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D007672:Kidney Cortex / Q000187:drug effects / Q000201:enzymology; D007679:Kidney Medulla / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009761:Nystatin / Q000633:toxicity; D011090:Polyenes / Q000633:toxicity; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D000900:Anti-Bacterial Agents; D011090:Polyenes; D009761:Nystatin; D002174:Candicidin; D000666:Amphotericin B; D011451:Prostaglandin-Endoperoxide Synthases
Aktivnost' prostaglandinsintetazy v raznykh sloiakh pochek molodykh krys pri deĭstvii polienovykh antibiotikov.