Comparison of nimesulide and flurbiprofen in the treatment of non-infectious acute inflammation of the upper respiratory tract.
Sixty patients were enrolled in a controlled randomized single-blind study to compare the efficacy and tolerability of 200 mg/day nimesulide and 300 mg/day flurbiprofen given for 7 days, in the treatment of non-infectious acute inflammation of the upper respiratory tract. Patients were diagnosed as follows: pharyngitis, 20 (33.4%) cases; laryngitis 11 (18.3%) cases; tonsillitis, eight (13.3%) cases; and mixed forms, 21 (35.0%) cases. Both drugs showed the same efficacy in reducing mucosal congestion, local redness, fever and sore throat. Nimesulide treatment gave rise to fewer and less severe side-effects than flurbiprofen treatment.
Cadeddu
L
L
Ear, Nose and Throat Clinic, Cagliari, Italy.
Piragine
F
F
Puxeddu
P
P
Scornavacche
V
V
Sellari Franceschini
S
S
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D005480:Flurbiprofen / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007827:Laryngitis / Q000188:drug therapy*; D008297:Male; D010612:Pharyngitis / Q000188:drug therapy*; D011422:Propionates / Q000627:therapeutic use*; D011897:Random Allocation; D013449:Sulfonamides / Q000009:adverse effects / Q000627:therapeutic use*; D014069:Tonsillitis / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; D013449:Sulfonamides; D005480:Flurbiprofen; C012655:nimesulide