Susceptibility to beta-lactam antibiotics and gentamicin of gram-negative bacilli isolated from hospitalized patients: a Swedish multicenter study.
A total of 952 blood and 1543 urine isolates of gram-negative bacilli from hospitalized patients in 1986-1987 were consecutively collected by 10 Swedish laboratories and tested for susceptibility to 8 beta-lactam antibiotics and to gentamicin. The isolates were mostly Escherichia coli (58% and 44%, respectively) and Klebsiella sp. (17% and 18%). Resistance to ampicillin in blood and urine isolates was found in 35% and 45%, respectively, to piperacillin in 5% and 6%, to cephalothin in 26% and 34%, to cefuroxime in 12% and 22%, to cefotaxime in 3% and 5%, to ceftazidime in 1% and 1%, to imipenem in 0.5% and 0.1%, to aztreonam in 3% and 2%, and to gentamicin in 0.8% and 0%. Resistance of clinically important gram-negative bacilli to new beta-lactam antibiotics and to gentamicin is infrequent in Sweden.
Dornbusch
K
K
Department of Clinical Microbiology, Karolinska Hospital, Stockholm, Sweden.
Bengtsson
S
S
Brorson
J E
JE
Fritz
H
H
Henning
C
C
Kronvall
G
G
Larsson
P
P
Malmborg
A S
AS
Thore
M
M
Tärnvik
A
A
D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001437:Bacteriuria / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D015337:Multicenter Studies as Topic; D018805:Sepsis / Q000382:microbiology*; D013548:Sweden
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D000667:Ampicillin