Hypoprothrombinemia due to cefamandole.
Two patients are described with severe coagulation disturbances, in one instance leading to extensive skin bleeding, secondary to the use of cefamandole. This cefalosporin antibiotic carries the same N-methylthiotetrazole side chain as moxalactam. Pathogenetic mechanisms leading to hypoprothrombinemia, its prevention and treatment are discussed.
Conraads
V M
VM
Department of Intensive Care, University of Antwerp, University Hospital, Belgium.
Demey
H E
HE
Heytens
L G
LG
Bossaert
L L
LL
D000368:Aged; D000671:Amputation, Surgical; D002435:Cefamandole / Q000009:adverse effects* / Q000627:therapeutic use; D003925:Diabetic Angiopathies / Q000601:surgery; D005260:Female; D006474:Hemorrhagic Disorders / Q000139:chemically induced*; D006801:Humans; D007020:Hypoprothrombinemias / Q000139:chemically induced*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy; D011183:Postoperative Complications / Q000188:drug therapy
D002435:Cefamandole