[The role of nontranscribable chromatin in the cellular mechanisms of morphogenesis].
The current ideas about realization of all the genetic information via stage-specific transcription and translation do not account for morphogenetic processes in space. The physical continuity of some cellular structures is only one of the mechanisms underlying the inheritance of morphofunctional properties. A suggestion was put forward that morphogenetic information is contained in nontranscribed DNA sequences. Specific interaction of these sequences with each other and with the nuclear membrane determine the spatial organization of the nucleus and program the functional properties of the endoplasmic reticulum membranes. Interaction between the nucleus and other cell structures, its localization and orientation determine the cell's polar properties and, consequently, morphogenesis of tissues and organs.
Maksimovskiĭ
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LF
D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000648:ultrastructure; D002843:Chromatin / Q000235:genetics / Q000648:ultrastructure*; D004247:DNA / Q000235:genetics / Q000648:ultrastructure; D009024:Morphogenesis; D014158:Transcription, Genetic
D002843:Chromatin; D004247:DNA
O roli netranskribiruemogo khromatina v kletochnykh mekhanizmakh morfogeneza.