Changes in TRH immunoreactivity in spinal cord after experimental spinal injury.
Concentrations of immunoreactive TRH (TRH-ir) in rat spinal cord were examined after traumatic injury. TRH-ir was significantly increased at the injury site (thoracic region) and rostral areas (cervical region), and significantly decreased below the injury site. Changes were delayed and time-dependent. Since TRH may serve as an excitatory neurotransmitter within the spinal cord, these changes may contribute to the functional alterations observed after spinal injury.
Faden
A I
AI
Hill
T G
TG
Kubek
M J
MJ
D000818:Animals; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000032:analysis*; D013119:Spinal Cord Injuries / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000032:analysis*
D013973:Thyrotropin-Releasing Hormone