[Reduction of the behavioral response to a viscero-peritoneal nociceptive stimulation during the development of experimental polyarthritis in the rat].
Writhing behaviour induced by a viscero-peritoneal nociceptive stimulus (i.p. acetic acid) has been investigated during the development of arthritis experimentally induced in rats by s. c. injection of Mycobacterium butyricum; experiments were carried out at various (1-9 weeks) post-inoculation periods. In the most severe phase (2-5 weeks post-inoculation), when arthritis-induced hyperaesthesia was most pronounced, writhing behaviour was strongly reduced (80%). In the following period, the progressive decrease of hyperaesthesia was contemporaneous with a recovery of the writhing behaviour. We conclude that, in this chronic pain model, the behavioural reaction to a viscero-peritoneal nociceptive stimulus is impaired. Such heterotopic inhibitory processes could be relevant to some paradoxical clinical observations such as the masking of a pain by the experience of pain at another locus (i. e. counter-irritation phenomenon).
Calvino
B
B
Le Bars
D
D
D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D001168:Arthritis / Q000503:physiopathology*; D001169:Arthritis, Experimental / Q000150:complications / Q000503:physiopathology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D002908:Chronic Disease; D008297:Male; D010146:Pain / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000085:Acetates; D019342:Acetic Acid
Réduction de la réponse comportementale à une stimulation nociceptive viscéro-péritonéale au cours du développement d'une polyarthrite expérimentale chez le rat.