title: Renal cadaveric transplantation in diabetics using total lymphoid irradiation or cyclosporin A. A controlled randomized study. Leuven Collaborative Transplantation Group.
abstract: A total of 20 renal transplant patients with end-stage diabetic nephropathy entered a randomized controlled trial comparing preoperative, fractionated total lymphoid irradiation (TLI) (radiation dose, 20-30 Gy) with postoperative cyclosporin A (CsA). Both groups received postoperative low-dose methylprednisolone maintenance therapy. The 3-year patient and graft survival was similar for both groups (100% and 71% in the TLI and 75% and 75% in the CsA group, respectively). Rejection crises occurred significantly more frequently (P less than 0.01) in the TLI-treated recipients. The incidence of infectious or diabetic complications was not significantly different in both groups. It is concluded that TLI and CsA are both effective treatment modalities for cadaveric renal transplantation in diabetics; CsA, however, is superior in preventing rejection crises.
authors.affiliation: Department of Nephrology, University Hospital Gasthuisberg, University of Leuven, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Waer
authors.forename: Y
authors.initials: Y
authors.lastname: Vanrenterghem
authors.forename: L
authors.initials: L
authors.lastname: Roels
authors.forename: R
authors.initials: R
authors.lastname: Verberckmoes
authors.forename: D
authors.initials: D
authors.lastname: Hauglustaine
authors.forename: E
authors.initials: E
authors.lastname: van der Schueren
authors.forename: T
authors.initials: T
authors.lastname: Lerut
authors.forename: J
authors.initials: J
authors.lastname: Gruwez
authors.forename: R
authors.initials: R
authors.lastname: Bouillon
authors.forename: M
authors.initials: M
authors.lastname: Vandeputte
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000175:diagnosis*; D003524:Cyclosporins / Q000494:pharmacology*; D003928:Diabetic Nephropathies / Q000150:complications*; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D015182:Lymphatic Irradiation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis*; D011239:Prednisolone / Q000008:administration & dosage; D011897:Random Allocation; D013997:Time Factors
chemical_list: D003524:Cyclosporins; D011239:Prednisolone