Penicillinase-producing Neisseria gonorrhoea as a cause of neonatal and adult ophthalmia.
A retrospective analysis of 80 cases of gonococcal ophthalmia revealed six (7.5%) to be due to penicillinase-producing Neisseria gonorrhoeae (PPNG), five neonatal cases and one adult. All six cases were finally cured, but best results were obtained with topical chloramphenicol and single-dose spectinomycin (40 mg/kg) given intramuscularly. All gonococcal isolates should be tested promptly for penicillinase production, and if this is present systemic treatment, modified to spectinomycin or penicillinase-stable cephalosporin, should be given as single-dose treatment.
Lockie
P
P
Leong
L K
LK
Louis
A
A
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003231:Conjunctivitis / Q000188:drug therapy / Q000209:etiology; D009877:Endophthalmitis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D006069:Gonorrhea / Q000150:complications* / Q000188:drug therapy / Q000201:enzymology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology*; D009344:Neisseria gonorrhoeae / Q000201:enzymology / Q000302:isolation & purification; D010403:Penicillin Resistance; D010405:Penicillinase / Q000096:biosynthesis*; D010406:Penicillins / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D010406:Penicillins; D010405:Penicillinase