[Characteristics of the sensitivity of the pancreatic beta cells to arginine and glucose in patients with type-2 diabetes mellitus].
The sensitivity of pancreatic beta-cells to i. v. injection of glucose and arginine was determined in patients with insulin-independent diabetes mellitus (IIDM) of various duration and with different therapeutic response to sugar lowering drugs (SLD). In a group of healthy persons who were examined in a similar way, a peak rise of insulin was observed after injection of glucose and arginine. A peak rise of insulin after glucose administration was absent in patients managed with SLD, whereas an insulin level during the arginine test reached 302 +/- 12.7 pmol/l. In most of the patients showing resistance to SLD, who received insulin therapy after examination, a maximum insulin level value was 106 +/- 12.1 pmol/l only. Thus the arginine test can be used to state SLD therapy inefficacy and for substantiation of insulin therapy.
Balabolkin
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AP
D000328:Adult; D000368:Aged; D001120:Arginine; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D004351:Drug Resistance; D005260:Female; D005951:Glucose Tolerance Test; D005905:Glyburide / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000097:blood / Q000627:therapeutic use; D007515:Islets of Langerhans / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D001120:Arginine; D005905:Glyburide
Kharakteristika chuvstvitel'nosti beta-kletok podzheludochnoĭ zhelezy k argininu i gliukoze u bol'nykh sakharnym diabetom II tipa.