Arteriosclerotic change in the human abdominal aorta in vivo in relation to coronary heart disease and risk factors.
In 137 living subjects, arteriosclerotic change in the human abdominal aorta was examined in relation to coronary heart disease (CHD) using a new ultrasonic method. The pressure strain elastic modulus (Ep) was calculated as an index of elastic properties from which arteriosclerotic change in the aorta was estimated. Thirty-one patients with CHD and 36 subjects with hypertension showed progression of the arteriosclerotic change in the abdominal aorta compared with 70 normal controls with the same age distribution (40-60 yrs). The Ep values were 1.03 +/- 0.27 X 10(6) dyne/cm2 in the normal group, and were elevated significantly (P less than 0.001) to 1.81 +/- 0.55 X 10(6) dyne/cm2 in the CHD group, and 1.95 +/- 1.31 X 10(6) dyne/cm2 in the hypertensive group. A significant correlation (r = 0.49, P less than 0.01) between the Ep values of the abdominal aorta and serum total cholesterol was observed in the CHD group. It was shown in living human subjects that the progression of arteriosclerotic change in the abdominal aorta was associated with coronary heart disease, and that some coronary risk factors, such as hypertension and serum total cholesterol, also affected arteriosclerotic change in the abdominal aorta.
Imura
T
T
Department of Cardiovascular Medicine, School of Medicine, Hokkaido University, Japan.
Yamamoto
K
K
Satoh
T
T
Mikami
T
T
Yasuda
H
H
D001012:Aorta, Abdominal / Q000473:pathology*; D001018:Aortic Diseases / Q000150:complications / Q000473:pathology*; D001161:Arteriosclerosis / Q000097:blood / Q000150:complications / Q000473:pathology*; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014463:Ultrasonography / Q000295:instrumentation
D002784:Cholesterol