Eicosanoids and platelet activating factor mechanisms in organ rejection.
In summary, the eicosanoids and PAF modulate the immune response in vitro and in vivo. The PG seem to attenuate and TX, LT, and PAF to potentiate the cell-mediated immune response. In addition, these compounds have nonimmunologic effects that may modify the edema and decreased blood flow associated with the rejection process.
Foegh
M L
ML
Department of Surgery, Georgetown University Medical Center, Washington, DC 20007.
D000818:Animals; D006084:Graft Rejection / Q000187:drug effects; D015289:Leukotrienes / Q000502:physiology*; D010972:Platelet Activating Factor / Q000502:physiology*; D011453:Prostaglandins / Q000502:physiology*; D013931:Thromboxanes / Q000502:physiology*
D015289:Leukotrienes; D010972:Platelet Activating Factor; D011453:Prostaglandins; D013931:Thromboxanes