title: Membranoproliferative glomerulonephritis in a patient with primary Sjögren's syndrome. Report of a case with review of the literature.
abstract: Glomerulonephritis complicating primary Sjögren's syndrome is extremely rare, with only 3 cases of membranoproliferative glomerulonephritis reported in the literature. We report on a 55-year-old woman with a long-standing history of dryness of the mouth and eyes who was found to have nephrotic syndrome. Extensive investigations indicated primary Sjögren's syndrome. Kidney biopsy revealed a membranoproliferative glomerulonephritis. Treatment with prednisone and cyclophosphamide resulted in complete remission of nephrotic syndrome. The pathogenesis of glomerulonephritis appears to be due to deposition of circulating immune complexes.
authors.affiliation: King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: M A
authors.initials: MA
authors.lastname: Khan
authors.forename: M
authors.initials: M
authors.lastname: Akhtar
authors.forename: S M
authors.initials: SM
authors.lastname: Taher
mesh_terms: D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications*