Plasma clearance rates of coagulation factors VIII and IX in factor-deficient individuals.
The plasma clearance rates of factors IX and VIII were determined in patients with hemophilia A and B who had received factor replacement by prolonged, continuous infusion of factor concentrates. The clearance rates were calculated by dividing the factor infusion rates by the steady-state plasma factor activities corrected for base-line factor activities. The mean factor IX clearance rate in eight factor IX-deficient patients was 233 mL/h (range 159 to 340 mL/h). The mean normalized clearance rate was 3.4 mL/h/kg. The mean factor VIII clearance rate in eight factor VIII-deficient patients was 294 mL/h (range 229 to 361 mL/h) and the mean normalized rate was 5.0 mL/h/kg. Both factors show linear relationships between the factor infusion rates and the steady-state plasma factor activities achieved.
Noe
D A
DA
Bell
W R
WR
Ness
P M
PM
Levin
J
J
D005164:Factor IX / Q000008:administration & dosage / Q000378:metabolism*; D005169:Factor VIII / Q000008:administration & dosage / Q000378:metabolism*; D006467:Hemophilia A / Q000097:blood* / Q000628:therapy; D002836:Hemophilia B / Q000097:blood* / Q000628:therapy; D006801:Humans; D007263:Infusions, Parenteral; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D012044:Regression Analysis; D013997:Time Factors
D005169:Factor VIII; D005164:Factor IX