Genotoxic effects of a variety of sterigmatocystin-related compounds in the hepatocyte/DNA-repair test and the Salmonella microsome assay.
The genotoxicity and mutagenicity of 11 fungal metabolites structurally related to sterigmatocystin were examined in the hepatocyte primary culture/DNA-repair test and the Salmonella microsome assay. 10 out of the mycotoxins, i.e. dihydrosterigmatocystin, 5-methoxysterigmatocystin, 5-methoxydihydrosterigmatocystin, 5,6-dimethoxysterigmatocystin, 5,6-dimethoxydihydrosterigmatocystin, sterigmatin, O-methylsterigmatocystin and O-acetylsterigmatocystin showed a positive response for DNA repair, suggesting their carcinogenic potency. 5-Methoxysterigmatocystin, 5,6-dimethoxysterigmatocystin demethylsterigmatocystin and O-acetylsterigmatocystin were mutagenic in TA100 of the bacterial mutagenicity assay with liver S9.
Mori
H
H
Sugie
S
S
Yoshimi
N
N
Kitamura
J
J
Niwa
M
M
Hamasaki
T
T
Kawai
K
K
D000107:Acetylation; D016604:Aflatoxin B1; D000348:Aflatoxins / Q000494:pharmacology; D000818:Animals; D004260:DNA Repair / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008745:Methylation; D009152:Mutagenicity Tests; D051381:Rats; D011912:Rats, Inbred ACI; D012486:Salmonella typhimurium / Q000187:drug effects; D013241:Sterigmatocystin / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000494:pharmacology*
D000348:Aflatoxins; D014966:Xanthenes; D013241:Sterigmatocystin; D016604:Aflatoxin B1