title: [Hyperthyroidism in the thyroid hormone treatment of iodine deficiency goiter].
abstract: Standardized assessment of 1973 patients with iodine-deficient goitre, treated on average with 100 micrograms thyroxin, revealed clinical signs of thyroid hyperfunction in 2.4%. But an increased hormone concentration alone was not sufficient for the diagnosis. Probable cause of hyperfunction was autonomy of the goitre, as indicated by a negative TRH test before treatment had begun. It was calculated that in this case the risk of hyperthyroidism from thyroid hormone administration was 10%, but only 0.7% in patients with a primarily positive TRH test. Hyperthyroid symptoms disappeared and hormone concentration became normal in 60% of patients after thyroid-hormone administration had been stopped. It is concluded that patients with primarily negative TRH test must be carefully monitored while receiving thyroid-hormone treatment.
authors.forename: D
authors.initials: D
authors.lastname: Emrich
authors.forename: G
authors.initials: G
authors.lastname: Klaushenke
mesh_terms: D004338:Drug Combinations; D006042:Goiter / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000378:metabolism; D007455:Iodine / Q000172:deficiency* / Q000652:urine; D011877:Radionuclide Imaging; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D013963:Thyroid Hormones / Q000009:adverse effects* / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000009:adverse effects; D013997:Time Factors; D014284:Triiodothyronine / Q000009:adverse effects
chemical_list: D004338:Drug Combinations; D013963:Thyroid Hormones; D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D007455:Iodine; D013974:Thyroxine
vernacular_title: Hyperthyreose bei Schilddrüsenhormonbehandlung der Jodmangelstruma.