title: Possible involvement of nuclei in cadmium-induced modifications of cultured cells.
abstract: Reduced metaphase number and shortening of metaphase chromosomes were detected in McCoy cells exposed to 100 microM CdSO4 (maximal exposure time: 7 h). One hour exposure to 109Cd was enough to label the cell nucleus. This possibly suggests an early nuclear involvement in Cd-induced cell damage.
authors.affiliation: Institutes of Pharmacology, University of Sassari, Italy.
authors.forename: M A
authors.initials: MA
authors.lastname: Fighetti
authors.forename: M
authors.initials: M
authors.lastname: Miele
authors.forename: A
authors.initials: A
authors.lastname: Montella
authors.forename: M S
authors.initials: MS
authors.lastname: Desole
authors.forename: A M
authors.initials: AM
authors.lastname: Congiu
authors.forename: V
authors.initials: V
authors.lastname: Anania
mesh_terms: D000818:Animals; D002104:Cadmium / Q000378:metabolism / Q000633:toxicity*; D002106:Cadmium Radioisotopes; D002467:Cell Nucleus / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D002478:Cells, Cultured; D002875:Chromosomes / Q000187:drug effects / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D051379:Mice
chemical_list: D002106:Cadmium Radioisotopes; D002104:Cadmium