Enhanced resistance to listeriosis induced in mice by preinoculation treatment with T-2 mycotoxin.
The effect of T-2 toxin on cell-mediated resistance to bacterial infection was evaluated in mice challenge exposed with Listeria monocytogenes. Mice were treated orally on days -5, -4, -3, -2, -1, +1, and +3 with 2.0, 1.0, 0.5, or 0 mg of T-2 toxin/kg of body weight and were exposed to 10(6) (LD100) or 10(5) (LD50) L monocytogenes by intraperitoneal injection on day 0. Necrosis and depletion of lymphocytes in the thymus and spleen, decrease in thymus weight, reductions in the number of circulating total leukocytes and lymphocytes, and necrotizing gastroenteritis occurred in the toxin-treated mice. Although the cytotoxic effect of T-2 toxin on lymphoid tissue was marked, enhanced resistance to Listeria infection was revealed by significant (P less than 0.01) decreases in mortality caused by listeriosis in the toxin-treated mice. Mortality decreased from 100% to 64% in the mice exposed to 10(6) Listeria and from 50% to 20% in the mice exposed to 10(5) Listeria. Percentage of mortality after Listeria challenge exposure was dependent on the T-2 toxin dose and was progressively decreased in the mice given 0.5, 1.0, or 2.0 mg of toxin/kg.
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D000818:Animals; D005260:Female; D007113:Immunity, Innate / Q000187:drug effects*; D007958:Leukocyte Count; D008089:Listeria monocytogenes / Q000276:immunology; D008088:Listeriosis / Q000276:immunology* / Q000473:pathology; D008099:Liver / Q000033:anatomy & histology; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size; D012717:Sesquiterpenes / Q000494:pharmacology*; D013154:Spleen / Q000033:anatomy & histology; D013605:T-2 Toxin / Q000494:pharmacology*; D013950:Thymus Gland / Q000033:anatomy & histology; D013997:Time Factors
D012717:Sesquiterpenes; D013605:T-2 Toxin