Comparison of tinidazole given as a single dose and on 2 consecutive days for the treatment of nonspecific bacterial vaginosis.
Nonspecific bacterial vaginosis, defined as the presence of clue cells, was treated in a randomized, double-blind study with (1) tinidazole 2 g as a single dose (82 patients), (2) tinidazole 2 g on 2 consecutive days (84 patients), and (3) with placebo (81 patients). The cure rates, both clue cells and Gardnerella vaginalis absent, were 51, 74 and 4%, respectively. A closer clinical and microbiological evaluation showed the 2-day regimen to be superior.
Ekgren
J
J
Møllergaten spesiallegesenter, Oslo, Norway.
Norling
B K
BK
Degre
M
M
Midtvedt
T
T
D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006194:Gardnerella vaginalis / Q000187:drug effects; D006192:Haemophilus Infections / Q000188:drug therapy*; D006801:Humans; D009593:Nitroimidazoles / Q000008:administration & dosage*; D011897:Random Allocation; D014011:Tinidazole / Q000008:administration & dosage* / Q000627:therapeutic use; D014623:Vaginal Diseases / Q000188:drug therapy*
D009593:Nitroimidazoles; D014011:Tinidazole