title: Postnatal development of serotonin nerve fibers in the somatosensory cortex of mice studied by immunohistochemistry.
abstract: Postnatal serotonin (5HT) innervation in the cerebral cortex of mice has been studied by 5HT immunohistochemistry. 5HT-like immunoreactive (5HT-LI) nerve fibers and terminals appeared to increase transiently, particularly in the somatosensory (Sm) cortex during early postnatal days. As pups grow, 5HT afferent inputs decreased rapidly to reach a similar pattern of distribution to that in adult animals. Since the transient increase was seen at a critical period (seventh postnatal day) for the differentiation of layer IV, it is suggested that increased 5HT concentrations might have an effect on thalamocortical inputs and/or cortical lamination of the developing brains.
authors.forename: M
authors.initials: M
authors.lastname: Fujimiya
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: T
authors.initials: T
authors.lastname: Maeda
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation; D006892:Hydroxydopamines / Q000494:pharmacology; D007124:Immunoenzyme Techniques; D051379:Mice; D008813:Mice, Inbred ICR; D009434:Neural Pathways / Q000254:growth & development; D016627:Oxidopamine; D012701:Serotonin / Q000378:metabolism*; D013003:Somatosensory Cortex / Q000254:growth & development* / Q000378:metabolism; D013788:Thalamus / Q000254:growth & development
chemical_list: D006892:Hydroxydopamines; D012701:Serotonin; D016627:Oxidopamine