Dose-dependent impairment in the performance of a go-no go successive discrimination by chlordiazepoxide.
After learning a light-cued, go-no go successive discrimination to criterion, male Sprague-Dawley rats received 0, 5, or 10 mg/kg chlordiazepoxide on six performance sessions, followed by two drug-recovery (saline) sessions. Chlordiazepoxide impaired discrimination performance in a dose-dependent manner, with animals in the 5 mg/kg dose condition demonstrating tolerance to the drug after two performance sessions. The degree of discrimination impairment in both drug dose conditions paralleled an increase in responding during no-go phases of the performance task. These findings are consistent with a "disinhibitory hypothesis" of performance impairment and suggest that CDP-drugged animals have difficulty in withholding incorrect responses.
Cole
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Michaleski
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D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D003864:Depression, Chemical; D004192:Discrimination, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005502:Food; D008027:Light; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D002707:Chlordiazepoxide