Effect of drug-induced taurine depletion on cardiac contractility and metabolism.
Myocardial taurine content was halved in rats maintained for 3 weeks on tap water containing either 1% guanidinoethylsulfonate (GES) or 3% beta-alanine. The decrease in taurine content did not affect myocardial contraction; however, it significantly altered myocardial metabolism. The major effect of the treatment was a significant stimulation in the rate of glycolysis and lactate production. The rise in glycolytic flux was associated with activation of phosphofructokinase, presumably caused by a decrease in tissue citrate levels. GES-treated hearts also contained slightly lower creatine phosphate content, but since this effect was not observed in the beta-alanine-treated hearts, it appeared to be independent of taurine depletion. The consequences of these metabolic changes are discussed.
Mozaffari
M S
MS
Tan
B H
BH
Lucia
M A
MA
Schaffer
S W
SW
D000818:Animals; D006003:Glycogen / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D015091:beta-Alanine / Q000494:pharmacology
D007328:Insulin; D015091:beta-Alanine; D013654:Taurine; C009558:taurocyamine; D006003:Glycogen