Effect of mast cell stimulators or inhibitors on plasma lipids and aortic content of lipids, hexosamine and hydroxyproline in rats.
Twenty-one-day-old rats were treated with mast cell stimulators or inhibitors. Mast cell inhibition produced decrease of total cholesterol in plasma and aorta, while the stimulation led to an increase. Both stimulation and inhibition produced increased levels of plasma and aorta triglycerides, and decrease of aorta content of hexosamine, hydroxyproline and total protein; these same effects could be due to different release of specific mast cell mediators.
Bydlowski
S P
SP
Stivaletti
V L
VL
Douglas
C R
CR
D000818:Animals; D001011:Aorta / Q000032:analysis* / Q000187:drug effects; D001161:Arteriosclerosis / Q000209:etiology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004205:Cromolyn Sodium / Q000494:pharmacology; D006595:Hexosamines / Q000032:analysis*; D006909:Hydroxyproline / Q000032:analysis*; D008055:Lipids / Q000097:blood*; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D008076:Cholesterol, HDL; D006595:Hexosamines; D008055:Lipids; D003189:p-Methoxy-N-methylphenethylamine; D002784:Cholesterol; D004205:Cromolyn Sodium; D006909:Hydroxyproline