title: Use of the Romanian product Silimarina in the treatment of chronic liver diseases.
abstract: The Romanian product Silimarina (synonym Legalon) was administered in a randomized double-blind trial, to a group of 180 patients with chronic persistent hepatitis (CPH), chronic active hepatitis (CAH) and hepatic cirrhosis (HC). The trial lasted for 40 days. The results showed favourable effects similar with those obtained with other preparations produced by foreign drug industries. The Romanian product proved to have no toxic effect. The authors discuss the present possibilities of estimating the evolution of chronic liver disease.
authors.affiliation: N. Gh. Lupu Institute of Internal Medicine, Bucharest, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Tănăsescu
authors.forename: S
authors.initials: S
authors.lastname: Petrea
authors.forename: R
authors.initials: R
authors.lastname: Băldescu
authors.forename: E
authors.initials: E
authors.lastname: Macarie
authors.forename: C
authors.initials: C
authors.lastname: Chiriloiu
authors.forename: S
authors.initials: S
authors.lastname: Purice
mesh_terms: D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005419:Flavonoids / Q000627:therapeutic use*; D006521:Hepatitis, Chronic / Q000097:blood / Q000188:drug therapy; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000188:drug therapy; D008107:Liver Diseases / Q000097:blood / Q000188:drug therapy*; D011897:Random Allocation; D012838:Silymarin / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D005419:Flavonoids; D012838:Silymarin