T15 idiotype expression in the murine response to phosphorylcholine is actively regulated by genes linked to the Igh-C locus.
In this report, we demonstrate the existence of a regulatory system that can determine the relative expression of individual clones (idiotypes) within the total immune response to PC. Studies of Igh-C-congenic mice and backcross analysis demonstrate that this regulation is controlled by genes linked to the immunoglobulin heavy chain locus. The regulation acts in a trans fashion. The regulatory genes of one parental allele can control the expression of idiotopes coded for by both parental alleles. This regulation does not appear to affect the quantity of the response, but could affect the quality of the response, depending on the potential repertoire and avidity of the individual clones available to respond to a given antigenic challenge.
Stall
A M
AM
Quintáns
J
J
Loken
M R
MR
D000818:Animals; D002794:Choline / Q000031:analogs & derivatives*; D003433:Crosses, Genetic; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006462:Hemolytic Plaque Technique; D006579:Heterozygote; D007143:Immunoglobulin Heavy Chains / Q000235:genetics* / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000032:analysis*; D007075:Immunoglobulin M / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009194:Myeloma Proteins / Q000032:analysis*; D010767:Phosphorylcholine / Q000276:immunology*; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology
D007143:Immunoglobulin Heavy Chains; D007130:Immunoglobulin Idiotypes; D007075:Immunoglobulin M; D009194:Myeloma Proteins; C043925:myeloma protein TEPC15; D010767:Phosphorylcholine; D002794:Choline