Necrosis of the femoral head after renal transplantation.
The cumulated risk of developing necrosis of the femoral head following renal transplantation was 42/374 in patients treated with steroids and azathioprine, and 4/124 in patients treated with cyclosporine-A and a reduced dose of steroids. 29 of the osteonecrosis cases were bilateral, with the time lapse between the two sides rarely exceeding 6 months. The reduction in the rate of osteonecrosis paralleled a reduction in the number of rejection episodes during the first month after transplantation and in the cumulated dose of steroids 1 month and 1 year after transplantation. We concluded that the risk of femoral head necrosis following renal transplantation is reduced by using cyclosporin-A for immunosuppression, which caused less rejection episodes and consequently a reduction in steroid medication.
Lausten
G S
GS
Department of Orthopedics, University of Copenhagen, Denmark.
Jensen
J S
JS
Olgaard
K
K
D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000009:adverse effects; D005260:Female; D005271:Femur Head Necrosis / Q000209:etiology*; D005919:Glomerular Filtration Rate; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000097:blood; D011183:Postoperative Complications / Q000209:etiology*; D011241:Prednisone / Q000009:adverse effects; D011336:Probability
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D010758:Phosphorus; D003404:Creatinine; D002118:Calcium; D011241:Prednisone