Evaluation of the mutagenic activity of leucinostatins, a novel class of antibiotic peptides produced by Paecilomyces marquandii, in the modul Aspergillus nidulans.
Leucinostatins A, B, C, D, E, G, H, and K were thoroughly investigated for their genotoxic activity using the modul Aspergillus nidulans as the test organism. The results of assays for gene mutation (8-azaguanine resistance and methionine suppressors), gene conversion, mitotic crossing-over and mitotic aneuploidy induction suggest that these peptide antibiotics lack significant mutagenicity and that non-genotoxic mechanism(s) underlie their cytotoxic properties.
Crebelli
R
R
Istituto Superiore di Sanità, Rome, Italy.
Carere
A
A
Conti
G
G
Conti
L
L
Rossi
C
C
Tuttobello
L
L
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001233:Aspergillus nidulans / Q000187:drug effects* / Q000235:genetics; D008938:Mitosis; D003904:Mitosporic Fungi / Q000378:metabolism*; D009152:Mutagenicity Tests; D009154:Mutation; D010143:Paecilomyces / Q000378:metabolism*; D010455:Peptides / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D010455:Peptides