Extent of colocalization of serotonin and GABA in neurons of the ventral medulla oblongata in rat.
The colocalization of serotonin (5-hydroxytryptamine; 5-HT) and gamma-aminobutyric acid (GABA) in the ventral aspect of the rat medulla oblongata was studied using antibodies directed against 5-HT and GABA. Although 5-HT- and GABA-immunoreactive cell bodies were observed over the entire rostral-caudal extent of the ventral medulla, the colocalization of these two classical neurotransmitters in single cells was, for the most part, limited to a region that corresponds anatomically to nucleus raphe magnus/nucleus paragigantocellularis. Schematic drawings showing the distribution of 5-HT/GABA cell bodies in the ventral medulla are provided.
Millhorn
D E
DE
Department of Physiology, University of North Carolina, Chapel Hill 27599.
Hökfelt
T
T
Seroogy
K
K
Verhofstad
A A
AA
D000818:Animals; D005455:Fluorescent Antibody Technique; D008297:Male; D008526:Medulla Oblongata / Q000033:anatomy & histology / Q000166:cytology*; D009474:Neurons / Q000166:cytology*; D051381:Rats; D012701:Serotonin / Q000032:analysis*; D005680:gamma-Aminobutyric Acid / Q000032:analysis*
D012701:Serotonin; D005680:gamma-Aminobutyric Acid