NSAIDs and cartilage metabolism.
Data from experimental studies on the influence of non-steroidal anti-inflammatory drugs (NSAIDs) on cartilage is reviewed. There is evidence from this data that some NSAIDs exert a harmful effect, but also that other NSAIDs do not influence cartilage metabolism or could even have a moderate beneficial effect. So far the experimental data must be interpreted with great caution to the clinical situation and no firm conclusions could be drawn from the few clinical reports available. However, the high frequency of other side effects of NSAIDs in the elderly calls a restrictive prescription of these drugs to osteoarthritic patients.
Bjelle
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Department of Rheumatology, Sahlgren University Hospital, Gothenburg, Sweden.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002356:Cartilage / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D002358:Cartilage, Articular / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D046508:Culture Techniques; D004285:Dogs; D006652:Histological Techniques; D006801:Humans; D013583:Synovial Membrane / Q000502:physiology
D000894:Anti-Inflammatory Agents, Non-Steroidal