The effect of aldose reductase and its inhibition on sugar cataract formation.
Cataracts associated with diabetes and galactosemia are characterized by their rapid onset and bilateral appearance. These cataracts display similar morphology and histology and have common biochemical mechanisms initiating the cataractous processes. An understanding of these biochemical mechanisms have been aided both by the ability to reproduce these cataracts in various animal models and by the development of potent inhibitors of aldose reductase. This is a US government work. There are no restrictions on its use.
Kador
P F
PF
Akagi
Y
Y
Kinoshita
J H
JH
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D002386:Cataract / Q000188:drug therapy / Q000201:enzymology* / Q000209:etiology / Q000517:prevention & control; D048909:Diabetes Complications; D003921:Diabetes Mellitus, Experimental / Q000150:complications; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use; D048289:Imidazolidines; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D007908:Lens, Crystalline / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D009249:NADP / Q000378:metabolism; D009997:Osmotic Pressure; D010084:Oxidation-Reduction / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D012377:Rodentia; D013012:Sorbitol / Q000378:metabolism; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*
D007093:Imidazoles; D048289:Imidazolidines; D013012:Sorbitol; D009249:NADP; D013401:Sugar Alcohol Dehydrogenases; D007064:L-Iditol 2-Dehydrogenase; D000449:Aldehyde Reductase; C026411:sorbinil