title: [Evolution of bacterial resistance to five aminoglycosides. A study of 3,354 strains isolated in a hospital milieu].
abstract: The authors studied the susceptibility to 5 aminoglycosides (amikacin, dibekacin, gentamicin, netilmicin and tobramycin) of 3,354 strains isolated at the Centre Hospitalier Sud in Bordeaux during 1987. The results are compared to those obtained in 1984 on 2,818 strains. Amikacin remains the most active aminoside against the Enterobacteriaceae and Acinetobacter; against Pseudomonas, tobramycin has become the best one at that time, as well as netilmicin against Staphylococcus aureus. Evolution: no significative increase of Enterobacteriaceae resistance to aminoglycosides was observed during the last 3 years except for Providencia and Serratia. For Acinetobacter and Pseudomonas, percentage of resistant strains is respectively two-fold and three-fold higher. Although resistance increased in that species, netilmicin and amikacin showed a still good activity against Staphylococcus aureus.
authors.affiliation: Laboratoire de Bactériologie, Hôpital Xavier-Arnozan, Pessac.
authors.forename: J
authors.initials: J
authors.lastname: Fourche
authors.forename: J
authors.initials: J
authors.lastname: Texier-Maugein
authors.forename: M
authors.initials: M
authors.lastname: Mormede
mesh_terms: D000150:Acinetobacter / Q000187:drug effects; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D005075:Biological Evolution; D004352:Drug Resistance, Microbial / Q000235:genetics; D004755:Enterobacteriaceae / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D011549:Pseudomonas / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013997:Time Factors
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents
vernacular_title: Evolution de la résistance bactérienne à cinq aminosides. Etude portant sur 3,354 souches isolées en milieu hospitalier.