Effect of carbamazepine on mean urinary free cortisol excretion in patients with major affective illness.
Carbamazepine, a tricyclic anticonvulsant effective in the treatment of major affective disorder, has been observed to induce cortisol non-suppression following dexamethasone administration. The mechanism of this effect has not been clearly established. In this study, the authors report carbamazepine-induced elevations of mean urinary free cortisol in patients with affective illness. The theoretical and practical implications of these findings are discussed.
Rubinow
D R
DR
Post
R M
RM
Gold
P W
PW
Uhde
T W
TW
D002220:Carbamazepine / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine*; D019964:Mood Disorders / Q000652:urine*; D011863:Radioimmunoassay; D013997:Time Factors
D002220:Carbamazepine; D006854:Hydrocortisone