title: [The pathogenesis of systemic lupus erythematosus--data and considerations].
abstract: Systemic lupus erythematosus (SLE) is viewed as a prototype of generalized autoimmune disease. The causes and mechanisms of inflammatory damage to various organ systems are not known. In this article, we will try to conceive a synopsis of existing hypotheses from the literature and our own data in order to project directions for further research. The use of the methods of modern biotechnology promises further insights into details of the genetic predisposition to this disease as well as into environmental factors that lead to disordered immunoregulation and organ damage.
authors.affiliation: II. Medizinischen Universitätsklinik Wien.
authors.forename: W
authors.initials: W
authors.lastname: Graninger
authors.forename: J S
authors.initials: JS
authors.lastname: Smolen
mesh_terms: D001324:Autoantigens / Q000276:immunology; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology* / Q000235:genetics; D012307:Risk Factors
chemical_list: D001324:Autoantigens; D012739:Gonadal Steroid Hormones
vernacular_title: Die Pathogenese des systemischen Lupus erythematosus--Daten und Gedanken.