title: Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes.
abstract: We report the first and complete nucleotide sequence of a human gamma 3 heavy chain constant region gene (C gamma 3). This gene displays the same organization than the others C gamma genes and exhibits normal RNA splice and polyadenylation sites. A comparison of its primary sequence with those of C gamma 1, C gamma 2 and C gamma 4 genes confirms the high degree of homology (95%) of the human family in both coding and non-coding regions, and the divergence of the hinge region. The C gamma 3 gene we sequenced codes for a Gm(b) gamma 3 chain (EZZ). Comparison with other known protein sequences reveals that only two specific aminoacids are involved in the Gm(b) and Gm(g) allotypes, which suggests an important part of the spatial configuration in the allotypic specificities.
authors.forename: S
authors.initials: S
authors.lastname: Huck
authors.forename: P
authors.initials: P
authors.lastname: Fort
authors.forename: D H
authors.initials: DH
authors.lastname: Crawford
authors.forename: M P
authors.initials: MP
authors.lastname: Lefranc
authors.forename: G
authors.initials: G
authors.lastname: Lefranc
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D005075:Biological Evolution; D002874:Chromosome Mapping; D005796:Genes; D006801:Humans; D007127:Immunoglobulin Constant Regions / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007142:Immunoglobulin gamma-Chains / Q000235:genetics*; D007136:Immunoglobulins / Q000235:genetics*; D012326:RNA Splicing; D012689:Sequence Homology, Nucleic Acid
chemical_list: D007127:Immunoglobulin Constant Regions; D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains; D007136:Immunoglobulins