Metastatic ability and expression of c-fos oncogene in cell clones of a spontaneous rat mammary tumor.
It was found that cell clones c1-2, cl-2r, c1-3, c1-4 and c1-6 of a spontaneous rat mammary tumor, c-SST-2, exhibit different degrees of metastatic ability: c1-2, c1-3, c1-6 were highly metastatic, while c1-2r and c1-4 were weakly metastatic. The expression of several oncogenes in these clones was examined. The amounts of myc mRNA in the clones were nearly the same. Expression of N-ras mRNA was higher in c1-2r and c1-4 than in c1-2, c1-3 and c1-6. On the other hand, the amounts of fos mRNA in the weakly metastatic clones were markedly lower than those in the highly metastatic clones. These results suggest that fos oncogene plays a role in the high metastatic ability of c-SST-2.
Yuhki
N
N
Hamada
J
J
Kuzumaki
N
N
Takeichi
N
N
Kobayashi
H
H
D000818:Animals; D002460:Cell Line; D002999:Clone Cells; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000235:genetics* / Q000473:pathology; D009362:Neoplasm Metastasis; D009857:Oncogenes; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011918:Rats, Inbred SHR
D012333:RNA, Messenger