Multicenter private practice comparison of tripamide and hydrochlorothiazide in the treatment of hypertension.
One hundred fifty-nine patients with essential hypertension were randomly assigned to take 10 mg of tripamide or 50 mg of hydrochlorothiazide once a day for 12 weeks. Both drugs were equally effective in lowering both systolic and diastolic blood pressure in the supine (6/5 vs. 5/5 mm Hg) and standing (8/5 vs 7/6 mm Hg) positions. Tripamide had less effect on serum potassium (0.2 vs. 0.6 mEq/L decrease) and serum uric acid (0.7 vs. 1.2 mg/dL increase) than hydrochlorothiazide. The addition of propranolol to either drug produced a further reduction in blood pressure. The overall incidence and spectrum of adverse reactions were the same for both drugs.
Bope
E T
ET
Family Practice Center, Riverside Methodist Hospital, Columbus, OH 43214.
Adams
R C
RC
Brewer
S C
SC
Cairns
C B
CB
Fosnaugh
N R
NR
Leidheiser
P C
PC
Platt
C W
CW
Polsley
J S
JS
Romaker
R R
RR
Scarbrough
S D
SD
D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005194:Family Practice; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D015337:Multicenter Studies as Topic; D011331:Private Practice; D011897:Random Allocation
D000959:Antihypertensive Agents; D007211:Indoles; D006852:Hydrochlorothiazide; C031282:tripamide