title: Central 6-OHDA affects both open-field exploratory behaviour and the development of hypertension in SHR.
abstract: To investigate the possible relation between changes in behaviour and the development of hypertension in the spontaneously hypertensive rat (SHR), the effect of intracerebroventricular (ICV) administration of the catecholamine neurotoxin 6-hydroxydopamine (6-OHDA) on blood pressure and spontaneous behaviour was studied. In addition to an attenuation of the rise in blood pressure in SHR, 6-OHDA induced a marked decrease in rearing activity in the open field towards levels found in WKY. Other parameters were either not changed (stereotyped sniffing) or influenced in a comparable way in SHR and WKY (increase in locomotion). These results suggest that ICV 6-OHDA may simultaneously affect the development of hypertension and certain components of the changed behaviour of SHR. The exact relation between the two phenomena awaits further investigation.
authors.forename: M
authors.initials: M
authors.lastname: Van den Buuse
authors.forename: H D
authors.initials: HD
authors.lastname: Veldhuis
authors.forename: S
authors.initials: S
authors.lastname: de Boer
authors.forename: D H
authors.initials: DH
authors.lastname: Versteeg
authors.forename: W
authors.initials: W
authors.lastname: de Jong
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D005106:Exploratory Behavior / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006892:Hydroxydopamines / Q000494:pharmacology*; D006973:Hypertension / Q000503:physiopathology*; D007276:Injections, Intraventricular; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D002395:Catecholamines; D006892:Hydroxydopamines; D016627:Oxidopamine