title: [Dynamic tests in females with Kallmann syndrome].
abstract: Three patients with Kallmann's syndrome (one of whom had undergone eight-year therapy with sex steroids) were studied with many dynamic tests. The progesterone and clomiphene tests were negative. An insulin test and TRH stimulation test showed a normal pool of GH and TSH in the hypophysis. A double stimulation with 100 micrograms LH-RH led to an inadequate gonadotropin response with a dominant FSH secretion, while the patient who had previously received sex steroids gave better results. The other two patients received 100 micrograms LH-RH i.m. daily for 20 days and the double LH-RH stimulation test was repeated. A satisfactory gonadotropin response with a predominance of LH secretion was noted. A TRH stimulation test revealed normal PRL secretion, while after a chlorpromazine test only one patient showed a satisfactory PRL secretion. Under combined HMG-HCG therapy, one of the patients conceived and had a normal outcome of her pregnancy.
authors.forename: A
authors.initials: A
authors.lastname: Chryssikopoulos
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D013006:Growth Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007006:Hypogonadism / Q000097:blood / Q000175:diagnosis*; D007328:Insulin; D007986:Luteinizing Hormone / Q000097:blood; D000857:Olfaction Disorders / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011374:Progesterone; D011388:Prolactin / Q000097:blood; D013577:Syndrome; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone
chemical_list: D006728:Hormones; D007328:Insulin; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D006854:Hydrocortisone
vernacular_title: Dynamische Tests an Frauen mit Kallmann-Syndrom.