Chelation in metal intoxication XVIII: Combined effects of thiamine and calcium disodium versenate on lead toxicity.
Calcium disodium ethylenediaminetetraacetate (Ca-Na2EDTA; Versenate) was more effective than thiamine (vitamin B1) in enhancing the urinary excretion of lead, reducing tissue lead and restoring lead induced biochemical alterations in rats. However, the combination of CaNa2EDTA and vitamin B1 enhanced the beneficial effect of CaNa2EDTA in lead intoxication and was particularly effective in reducing the brain concentration of lead.
Flora
S J
SJ
Singh
S
S
Tandon
S K
SK
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004347:Drug Interactions; D004492:Edetic Acid / Q000494:pharmacology / Q000627:therapeutic use; D006413:Hematopoietic System / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007854:Lead / Q000652:urine; D007855:Lead Poisoning / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D000623:Porphobilinogen Synthase / Q000378:metabolism; D051381:Rats; D013831:Thiamine / Q000627:therapeutic use*
D007854:Lead; D004492:Edetic Acid; D000623:Porphobilinogen Synthase; D013831:Thiamine