title: Effects of erythromycin base and erythromycin esters on protein synthesis in vivo in Escherichia coli.
abstract: The inhibitory effects on protein synthesis in vivo of erythromycin base and several erythromycin esters have been determined. An experimental method was used, especially suited for studies on short-lived antibiotics causing low levels of inhibition. Most of the tested derivatives were 2-3% as active as erythromycin base while a split product of erythromycin, anhydroerythromycin, was 4% as effective.
authors.affiliation: Department of Molecular Biology, Biomedical Center, Uppsala, Sweden.
authors.forename: S G
authors.initials: SG
authors.lastname: Andersson
authors.forename: C G
authors.initials: CG
authors.lastname: Kurland
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis*; D004917:Erythromycin / Q000031:analogs & derivatives / Q000494:pharmacology*; D004926:Escherichia coli / Q000378:metabolism*; D004952:Esters / Q000494:pharmacology; D005838:Genotype; D012270:Ribosomes / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D004952:Esters; D004917:Erythromycin