title: Porcine factor VIII and plasmapheresis in the management of hemophiliac patients with inhibitors.
abstract: Management of hemophiliac patients with inhibitors can be a difficult problem. We report here a patient with severe hemophilia A, a high titer inhibitor, and an abdominal abscess requiring surgery. Despite significant cross reactivity of the inhibitor with porcine FVIII, he was successfully managed with plasmapheresis and porcine FVIII infusions. Other approaches to the management of such patients are briefly reviewed.
authors.forename: R D
authors.initials: RD
authors.lastname: Bona
authors.forename: D N
authors.initials: DN
authors.lastname: Pasquale
authors.forename: R I
authors.initials: RI
authors.lastname: Kalish
authors.forename: B A
authors.initials: BA
authors.lastname: Witter
mesh_terms: D000818:Animals; D005169:Factor VIII / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D006467:Hemophilia A / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D010956:Plasmapheresis; D013552:Swine
chemical_list: D005169:Factor VIII