title: [Pathogenesis and drug therapy of acute laminitis in horses: a literature review].
abstract: Impairment of the microcirculation in the distal part of the foot is an important factor in the aetiology of equine laminitis. To prevent the development of chronic laminitis and the resulting complications, two new therapeutical principles were tested in the treatment of acute laminitis. Thrombosis which frequently occurs in the corium of the foot, could be controlled by administration of anticoagulants such as heparin. Alpha-receptor blocking agents such as phenoxybenzamine were used, to improve the peripheral blood flow. The use of these drugs and that of anti-inflammatory agents during the onset of acute laminitis is discussed in this review paper.
authors.affiliation: Vakgroep Algemene Heelkunde en Heelkunde der Grote Huisdieren, Utrecht.
authors.forename: R
authors.initials: R
authors.lastname: Boosman
authors.forename: F
authors.initials: F
authors.lastname: Németh
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use*; D005552:Forelimb / Q000098:blood supply; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007794:Lameness, Animal / Q000188:drug therapy / Q000209:etiology*; D008833:Microcirculation; D013927:Thrombosis / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000893:Anti-Inflammatory Agents; D000925:Anticoagulants
vernacular_title: Pathogenese en medicamenteuze behandeling van acute hoefbevangenheid: een literatuuroverzicht.