[Hyponatremia induced by hypoglycemic sulfonamides: a study of 70 patients].
Sodium plasma level was followed every three months in 70 non insulin dependent diabetic patients; 112 prescriptions were performed. Five different oral hypoglycemic drugs were used but patients were taken no more than one drug in the same time. 21% of prescription were associated with a low sodium plasma level but it was beneath 129 meq in only 8% of them; a low sodium plasma level was observed with every oral hypoglycemic agent; when the drug was interrupted a normal sodium plasma level was restored; when patients were put under another agent, hyponatremia did not recidive. 67% of patients were free of any symptom. Interference with biological parameters, age of the patients, duration of diabetes and other therapy are studied.
Gin
H
H
Clinique Médicale et des Maladies Infectieuses, Hôpital Pellegrin, Bordeaux.
Lars
I
I
Morlat
P
P
Beauvieux
J M
JM
Aubertin
J
J
D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D007010:Hyponatremia / Q000139:chemically induced*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013449:Sulfonamides / Q000009:adverse effects*
D007004:Hypoglycemic Agents; D013449:Sulfonamides
Hyponatrémie induite par les sulfamides hypoglycémiants: étude chez 70 patients.