Ethanol-induced changes in morphology and strength of femurs of rats.
Chronic ingestion of ethanol resulted in ultrastructural and mechanical changes in rat femurs. Scanning electron microscopy of the distal end of the femur revealed that the trabeculae of bones from ethanol-fed rats were thinner, more columnar, and more extensive than those from control rats. Three-point bending tests of the rat femurs showed that the maximum force or so-called "strength" required to break the bone was less in ethanol- than in control-fed animals. A significant inverse correlation was observed between the strength required to break the femur and the dose of ethanol calculated on a body weight basis. For the first time our study presents quantitative proof that a relationship exists between bone strength and the consumption of ethanol in rats. The study revealed that ethanol consumption resulted in a weaker femur compared to controls. We suggest that a common mechanism may be responsible for the decreased bone strength of ethanol-fed rats and the increased incidence of fractures in human alcoholics.
Peng
T C
TC
Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill 27599.
Kusy
R P
RP
Hirsch
P F
PF
Hagaman
J R
JR
D000437:Alcoholism / Q000473:pathology; D000818:Animals; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology; D000431:Ethanol / Q000493:pharmacokinetics*; D005260:Female; D005269:Femur / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol