Acute effect of potassium canrenoate administration on renin-angiotensin, kallikrein-kinin and prostaglandin systems.
1. To investigate the possible effects of potassium canrenoate (PC) on plasma renin activity (PRA) and on renal prostaglandins (PGS) and kinins under elevated sodium and/or potassium intakes, a single dose of PC was administered to four groups of Wistar male rats. 2. They were fed a normal diet (C), a diet supplemented with 4% of NaCl, (Na), with 1% of KCl: (K) or both supplements (NaK). 3. PRA and urinary PGS excretion did not show changes after PC administration, but total urinary kinins showed higher values after the treatment in all groups. 4. A diuretic but not natriuretic effect was observed only in C animals. 5. In conclusion, the single dose of PC was able to stimulate urinary kinins and to spare potassium independently of dietary electrolyte supplements that were able to block the diuretic effect of the drug.
Lahera
V
V
Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, Madrid, España.
Cachofeiro
V
V
Duran
F
F
Cañizo
F J
FJ
Rodriguez
F J
FJ
Tresguerres
J A
JA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002191:Canrenoic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D004032:Diet; D004231:Diuresis / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007610:Kallikreins / Q000502:physiology*; D007705:Kinins / Q000502:physiology* / Q000652:urine; D008297:Male; D011188:Potassium / Q000652:urine; D011245:Pregnadienes / Q000494:pharmacology*; D011453:Prostaglandins / Q000502:physiology* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*; D012964:Sodium / Q000652:urine; D012982:Sodium, Dietary / Q000494:pharmacology
D007705:Kinins; D011245:Pregnadienes; D011453:Prostaglandins; D012982:Sodium, Dietary; D002191:Canrenoic Acid; D012964:Sodium; D007610:Kallikreins; D012083:Renin; D011188:Potassium