[Acquired anticoagulants in children. Apropos of a series of 35 cases].
The authors report the clinical and biological data in 35 children presenting with circulating anticoagulant. The discovery of this abnormality was fortuitous in 28 cases, on the occasion of preoperative tests. In all cases they consisted of anticoagulants of the antiprothrombinase type, directed against the phospholipidic part of the complex. In 34 cases, no thrombosis or hemorrhage complication occurred. Among the 18 children who were followed, anticoagulant disappeared spontaneously in 17 cases. Some aspects of the circulating antibodies are quite particular in children: the frequent lack of clinical expression, the frequent postviral or drug-related etiology, the most often spontaneously favourable outcome.
Munzer
M
M
Laboratoire central d'Hématologie, Hôpital Robert-Debré, Reims.
Behar
C
C
Droulle
C
C
D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010743:Phospholipids / Q000276:immunology*; D012189:Retrospective Studies; D013997:Time Factors
D001779:Blood Coagulation Factors; D010743:Phospholipids; C028128:antiprothrombinase
Les anticoagulants acquis de l'enfant. A propos d'une série pédiatrique de 35 cas.