[Renal functional effects of non-steroidal anti-inflammatory agents and prostaglandins].
Renal prostaglandins are important modulators of renal hemodynamic function. In basal conditions, inhibition of prostaglandin synthesis by nonsteroidal anti-inflammatory drugs (NSAID) has no significant effect on renal blood flow or glomerular filtration rate. However when sodium or water depletion are used to enhance the dependence of renal hemodynamics on renal prostaglandin synthesis, NSAID administration significantly decrease renal blood flow and glomerular filtration rate. A better use of these drugs is necessary to minimize these side-effects.
Ryckelynck
J P
JP
Service de Néphrologie, C.H.U. Clémenceau, Caen.
Hurault de Ligny
B
B
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D007674:Kidney Diseases / Q000139:chemically induced; D011453:Prostaglandins / Q000502:physiology*; D012079:Renal Circulation / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011453:Prostaglandins
Effets fonctionnels rénaux des anti-inflammatoires non stéroïdiens et des prostaglandines.