Invited contribution: an objective approach to the development of short-term tests predictive of carcinogenicity.
The Carcinogenicity Prediction and Battery Selection procedure was developed to address two problems: (1) the identification of highly predictive, yet cost-effective, batteries of short-term tests and (2) the objective prediction of the potential carcinogenicity of chemicals based upon the results of short-term tests even when a mixture of positive and negative results is obtained. In the present report the usefulness of the Carcinogenicity Prediction and Battery Selection procedure is demonstrated using benzo[a]pyrene, benzoin and diethylstilbestrol as examples. In addition, its applicability in the analysis of all the possible outcomes of a battery is illustrated together with an analysis of the worth of additional testing.
Rosenkranz
H S
HS
Department of Environmental Health Sciences, Case Western Reserve University, Cleveland, Ohio 44106.
Ennever
F K
FK
Chankong
V
V
Pet-Edwards
J
J
Haimes
Y Y
YY
D000818:Animals; D015197:Carcinogenicity Tests / Q000379:methods*; D002273:Carcinogens / Q000633:toxicity*; D004054:Diethylstilbestrol / Q000633:toxicity*; D006801:Humans; D011237:Predictive Value of Tests
D002273:Carcinogens; D004054:Diethylstilbestrol