Interleukin-1 in malnutrition.
The effect of malnutrition on the in vitro production of interleukin-1 by lipopolysaccharide stimulated circulating monocytes has been investigated in children suffering from kwashiorkor and marasmus. The interleukin-1 activity was significantly lower in children with severe malnutrition. Furthermore, macrophages from children with kwashiorkor produced factors that suppressed mouse thymocyte proliferation. These observations show a significant impairment of macrophage function and provide a mechanism for the suppression of cellular immunity in malnutrition.
Bhaskaram
P
P
Sivakumar
B
B
D002478:Cells, Cultured; D002675:Child, Preschool; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007375:Interleukin-1 / Q000096:biosynthesis*; D007732:Kwashiorkor / Q000276:immunology; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D011502:Protein-Energy Malnutrition / Q000276:immunology*
D007375:Interleukin-1; D007213:Indomethacin