[Elastases and pulmonary pathologies].
Various elastases classes normally reside in alveolar structure and are liable to degrade the elastin as well as the other macromolecular components of pulmonary extracellular matrix (collagen, proteoglycans, fibronectin...), during lung injury. The most are the polymorphonuclear or monocyte serine elastase and the macrophage metallo and cysteine elastases. Metalloelastase may also arise from pathogenic bacteria as Pseudomonas aeruginosa. In another part proteases elastase-type from fibroblasts, endothelial cells or alveolar macrophages might to be involved into the remodelling of lung connective tissue or pulmonary cells differentiation and activation. The regulation of elastolytic activities, is supported both by activators (as plasminogen activator...) and inhibitors (alpha 1 Pi, 2M, BrI, TIMP, bacterial inhibitors...). These inhibitors are mostly generated in situ from macrophages, monocytes or polymorphonuclear cells so allowing to control fast local elastolytic activity. Since alveolar macrophage can internalize leucocyte elastase, synthetize metalloelastases, and secrete their inhibitors and activators, it plays a complex role in the lung defense and during various pulmonary pathogenesis. In conclusion, the lung response to bacterial or viral infections, the intensity of alveolitis, the nature and the gravity of emphysematous or fibrotic lung lesions, as well as the tumour growth or metastatic pulmonary invasion may depend upon the lung elastolytic activities.
Lafuma
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CNRS UA 1174, Laboratoire de Biochimie du Tissu Conjonctif, Faculté de Médecine, Créteil, France.
D000818:Animals; D004549:Elastin / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000201:enzymology*; D008171:Lung Diseases / Q000201:enzymology* / Q000503:physiopathology; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000502:physiology*; D011650:Pulmonary Alveoli / Q000201:enzymology*; D011656:Pulmonary Emphysema / Q000201:enzymology; D011658:Pulmonary Fibrosis / Q000201:enzymology
D004549:Elastin; D010450:Endopeptidases; D010196:Pancreatic Elastase
Elastases et pathologies pulmonaires.