Activity of the human carcinogens benzidine and 2-naphthylamine in male mouse bone marrow micronucleus assays.
Conflicting reports exist in the literature regarding the activity of the human bladder carcinogens benzidine and 2-naphthylamine in the rodent bone marrow micronucleus assay. These chemicals have therefore been re-evaluated in mouse bone marrow micronucleus assays, and each gave a clear positive response in male mice 24 h after oral dosing of approximately 20% of the 4-day median lethal dose level. Experiments were repeated.
Mirkova
E
E
Institute of Hygiene and Occupational Health, Medical Academy, Sofia, Bulgaria.
Ashby
J
J
D015081:2-Naphthylamine / Q000633:toxicity*; D000818:Animals; D001560:Benzidines / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D015162:Micronucleus Tests; D009153:Mutagens; D009281:Naphthalenes / Q000633:toxicity*; D012016:Reference Values
D001560:Benzidines; D009153:Mutagens; D009281:Naphthalenes; C029876:benzidine; D015081:2-Naphthylamine