title: Cellular basis of genetic nonresponsiveness to egg white lysozyme.
abstract: Utilizing radiation chimeras, we have investigated the cellular level at which the low immunological responsiveness to egg white lysozyme C57Bl/10 mice is expressed. Both NR----F1 (responder) and F1----NR combinations were assessed. The results demonstrate that C57Bl/10 bone marrow can give rise to hen egg white lysozyme responsive cells, but this response requires that the antigen be presented by cells derived from high responder animals.
authors.forename: S
authors.initials: S
authors.lastname: Grimes
authors.forename: R J
authors.initials: RJ
authors.lastname: Scibienski
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D002645:Chickens; D002678:Chimera; D004529:Egg White; D005802:Genes, MHC Class II; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009113:Muramidase / Q000276:immunology*; D013154:Spleen / Q000166:cytology
chemical_list: D009113:Muramidase