title: Premenstrual syndrome. A double-blind cross-over study of treatment with dydrogesterone and placebo.
abstract: A double-blind, cross-over, placebo-controlled study of dydrogesterone (10 mg b.d.) in the treatment of premenstrual syndrome is described. Two groups of women were studied: secondarily referred hospital clinic patients, and self-referred patients. Only one-third of patients screened completed the study. All patients showed significant improvements in symptom scores during the course of the study, the only significant difference between placebo- and dydrogesterone-treated patients being an increase in frequency of breast tenderness and a decrease in pain with menstrual bleeding in the latter.
authors.affiliation: Whiteley Wood Clinic, Sheffield.
authors.forename: G A
authors.initials: GA
authors.lastname: Sampson
authors.forename: P R
authors.initials: PR
authors.lastname: Heathcote
authors.forename: J
authors.initials: J
authors.lastname: Wordsworth
authors.forename: P
authors.initials: P
authors.lastname: Prescott
authors.forename: A
authors.initials: A
authors.lastname: Hodgson
mesh_terms: D000328:Adult; D001940:Breast; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004394:Dydrogesterone / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced; D011293:Premenstrual Syndrome / Q000188:drug therapy*
chemical_list: D004394:Dydrogesterone