title: Anti-cancer action of metal complexes: electron transfer and oxidative stress?
abstract: Evidence is presented in support of an electron transfer mechanism for various metal complexes possessing anti-neoplastic properties. Cyclic voltammetry was performed on several metallocenes, bis(acetato)bis(imidazole)Cu(II), and coordination compounds (Cu or Fe) of the antitumor agents, bipyridine, phenanthroline, hydroxyurea, diethyldithiocarbamate, and alpha, alpha'-bis(8-hydroxyquinolin-7-yl)-4-methoxytoluene. The favorable reduction potentials ranged from +0.5 to -0.5 Electrochemical behavior is correlated in some cases with structure and physiological activity. Relevant literature data are discussed.
authors.affiliation: Department of Chemistry, University of Wisconsin-Milwaukee 53201.
authors.forename: P
authors.initials: P
authors.lastname: Kovacic
authors.forename: W J
authors.initials: WJ
authors.lastname: Popp
authors.forename: J R
authors.initials: JR
authors.lastname: Ames
authors.forename: M D
authors.initials: MD
authors.lastname: Ryan
mesh_terms: D000970:Antineoplastic Agents; D002614:Chelating Agents; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009942:Organometallic Compounds / Q000633:toxicity*; D010084:Oxidation-Reduction
chemical_list: D000970:Antineoplastic Agents; D002614:Chelating Agents; D009942:Organometallic Compounds