Adverse hepatic reactions associated with etretinate in patients with psoriasis--analysis of 22 cases.
In a retrospective study of 533 patients with psoriasis treated with etretinate in several centers in the United States, 22 adverse drug reactions related to hepatic dysfunction were reported. On analysis, 6 of these adverse hepatic reactions were probably drug related, 7 possibly related, 6 unlikely to be related and in 3 there was insufficient evidence to implicate or associate the reported event as a hepatic adverse reaction. Most of the adverse drug reactions were asymptomatic changes in liver function test (LFT). No death occurred which could be attributed to adverse hepatic reaction from etretinate.
Thirumoorthy
T
T
Middle Road Hospital, Singapore.
Shupack
J L
JL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D056486:Chemical and Drug Induced Liver Injury; D002986:Clinical Trials as Topic; D005050:Etretinate / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012189:Retrospective Studies
D005050:Etretinate