Intravenous infusion of a medium-chain triglyceride-enriched lipid emulsion.
There has been much interest in the parenteral use of medium-chain triglycerides (MCT) as a noncarbohydrate energy source. This study examines the effects of infusion iv into postabsorptive normal subjects with three doses (0.5, 1.0, 1.5 g/kg.15 h) of an emulsion containing 56% MCT and 44% long-chain triglyceride (LCT) and comparing its metabolic effect with infusions of normal saline (NS) and an emulsion containing LCT alone. There were significant increases in serum beta-hydroxybutyrate and acetoacetate 5 and 15 h after the start of the MCT-LCT infusions. Increases were seen only after 15 h of NS, while none was observed during LCT alone. Triglycerides were increased in a dose-related fashion with MCT-LCT and were increased even further with LCT alone. Glycerol increased in a dose-related fashion both during the MCT-LCT and LCT infusion beginning immediately (0.5 h) after the start of the infusion. With NS infusion, glycerol increased significantly only after 15 h of infusion. The MCT-LCT mixture and the highest LCT dose resulted in a significant (12%) increase in oxygen consumption after 5 h of infusion. There was no difference in oral glucose tolerance between the various infusions. Infusion of MCT results in significant ketogenesis and more study is needed to determine its clinical utility.
Weissman
C
C
Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York 10032-3784.
Chiolero
R
R
Askanazi
J
J
Gil
K M
KM
Elwyn
D
D
Kinney
J M
JM
D000090:Acetoacetates / Q000097:blood; D000328:Adult; D001786:Blood Glucose; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood; D008297:Male; D010101:Oxygen Consumption; D011659:Pulmonary Gas Exchange; D011863:Radioimmunoassay; D014280:Triglycerides / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology
D000090:Acetoacetates; D001786:Blood Glucose; D005217:Fat Emulsions, Intravenous; D006885:Hydroxybutyrates; D007328:Insulin; D014280:Triglycerides; C016635:acetoacetic acid