title: Paul-Bunnell antigen in murine T cell differentiation: abnormal expression in MRL/Mp-lpr/lpr mice.
abstract: Expression of Paul-Bunnell (P-B) antigen was studied on lymphoid cells of normal mice, autoimmune MRL/Mp-lpr/lpr (lpr), and congenic MRL/Mp-+/+(+/+) mice. Evidence was presented that the P-B antigen is a differentiation-associated antigen of murine T cells: Cells with high P-B pattern and density on normal T cells increased as their differentiation proceeded in the peripheral lymphoid tissues. In thymus, P-B antigen was predominantly expressed on hydrocortisone resistant and PNA nonagglutinable cells. The degree of P-B expression on T cells of peripheral lymphoid tissues correlated well with that of Lyt-1 and Lyt-2 antigens (r greater than 0.7). Similar studies on lymphocytes obtained from lpr and +/+ mice at different ages revealed that P-B antigen on the peripheral T cells of lpr mice began to decrease at 6 to 8 wk of age and that the majority of the cells became low P-B cells by 10 wk, accompanied by decrease in expression of Lyt-1 antigen. In contrast, its expression on lpr thymocytes did not differ from that of +/+ or normal mice. The lymph node cell population of lpr mice at the height of the lymphadenopathy was composed of 80% of low P-B and dull Lyt-1 cells and less than 15% of "normal" P-B and Lyt-1 positive cells. These results indicate distorted differentiation of the lpr peripheral lymphocytes that are responsible for the massive lymphadenopathy and the morbid processes.
authors.forename: T
authors.initials: T
authors.lastname: Katagiri
authors.forename: H
authors.initials: H
authors.lastname: Tomiyama
authors.forename: K
authors.initials: K
authors.lastname: Kano
mesh_terms: D000375:Aging; D000818:Animals; D000910:Antibodies, Heterophile; D000945:Antigens, Differentiation, T-Lymphocyte; D015478:Antigens, Heterophile / Q000032:analysis* / Q000276:immunology; D000950:Antigens, Ly / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D001666:Binding Sites, Antibody; D002454:Cell Differentiation; D005434:Flow Cytometry; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008817:Mice, Mutant Strains / Q000276:immunology*; D008819:Mice, Nude; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
chemical_list: D000910:Antibodies, Heterophile; D000945:Antigens, Differentiation, T-Lymphocyte; D015478:Antigens, Heterophile; D000950:Antigens, Ly; D000954:Antigens, Surface; D007075:Immunoglobulin M