The acid-base balance during the time course of endotoxin fever and sodium salicylate antipyresis in the rabbit.
Blood acid-base balance in sodium salicylate antipyresis was investigated in adult rabbits at ambient temperature of 21.5 +/- 0.5 degrees C. The experimental fever elicited by iv injection of lipopolysaccharide Escherichia coli 1 microgram/kg/ was accompanied by a slight metabolic acidosis. A decrease in pH by 0.09 and HCO3- by 4.8 mEq/1 was noticed during the rising phase of pyrogen fever. There were no concomitant changes in blood PCO2 during that period of time. Although the concentrations of HCO3- were decreasing till the end of the experiment, the parallel falls in PCO2 led to a partial compensation of the noticed acidosis. Pretreatment with 200 mg/kg of sodium salicylate /an hour's iv infusion/reduced the febrile response by 42% and completely reversed the postpyrogen changes in pH and HCO3-. The falls in PCO2 during antipyresis, however, were similar to those observed in febrile rabbits. Possible mechanisms by which sodium salicylate could affect the pyrogen-induced disturbances of acid-base balance are being considered.
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D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D004731:Endotoxins / Q000494:pharmacology*; D005334:Fever / Q000209:etiology / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008297:Male; D011817:Rabbits; D012119:Respiration / Q000187:drug effects; D012980:Sodium Salicylate / Q000097:blood / Q000494:pharmacology*; D013997:Time Factors
D004731:Endotoxins; D002245:Carbon Dioxide; D012980:Sodium Salicylate