title: Effect of DNA supercoiling and catabolite repression on the expression of the tetA genes in Escherichia coli.
abstract: The effect of novobiocin, a gyrase inhibitor, and of catabolite repression on the expression of different classes of tetA genes in Escherichia coli was studied. The results obtained showed that the complete induction of the tetA genes corresponding to classes A, B, and D depends on DNA supercoiling, and that the expression of the tetA genes corresponding to classes A and C is not under catabolite repression.
authors.affiliation: Departamento de Biología Molecular, Universidad Nacional Autónoma de México, México City.
authors.forename: P
authors.initials: P
authors.lastname: León
authors.forename: G
authors.initials: G
authors.lastname: Alvarez
authors.forename: F
authors.initials: F
authors.lastname: Díaz de León
authors.forename: M C
authors.initials: MC
authors.lastname: Gómez-Eichelmann
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D004269:DNA, Bacterial / Q000235:genetics; D004278:DNA, Superhelical / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D005786:Gene Expression Regulation; D008969:Molecular Sequence Data; D009675:Novobiocin / Q000494:pharmacology; D010957:Plasmids; D011401:Promoter Regions, Genetic; D011815:R Factors; D012097:Repressor Proteins / Q000096:biosynthesis / Q000235:genetics*; D013753:Tetracycline Resistance; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004278:DNA, Superhelical; D012097:Repressor Proteins; D014157:Transcription Factors; C034811:tetracycline resistance-encoding transposon repressor protein; D009675:Novobiocin