[Regulation of the biosynthesis of insulin-like growth factors and variation in the expression of their genes].
Insulin-Like growth factors (IGFs) biosynthesis varies from one tissue to another, according to the stage of the development and to the hormonal environment. Growth hormone and nutritional factors have predominant role on the IGF expression. Molecular biology of the IGF may give a complementary understanding in the regulation of their biosynthesis. The IGF 1 gene located on chromosome 12 produce two messenger RNA, which encode for two preproIGF 1, but yields the same mature protein. The role of these two preproIGF 1 are not elucidated. Moreover, others variations in the 3' non coding region are observed. The IGF 2 gene is located on chromosome 11, and the variability of the IGF 2 mRNA according to tissue and stage of development, is mostly due to different 5' non coding exon use. Some examples of IGF 1 mRNA regulation by growth hormone (endocrine control) or during unilateral nephrectomy (autocrine and paracrine control) are presented.
Le Bouc
Y
Y
Laboratoire d'explorations fonctionnelles endocrinologiques, Hôpital Trousseau, Paris.
D000367:Age Factors; D000818:Animals; D005786:Gene Expression Regulation; D005796:Genes; D008970:Molecular Weight; D009392:Nephrectomy; D012333:RNA, Messenger / Q000235:genetics; D013002:Somatomedins / Q000096:biosynthesis* / Q000235:genetics
D012333:RNA, Messenger; D013002:Somatomedins
Régulation de la biosynthèse des insulin-like growth factors et variation de l'expression de leurs gènes.