title: Heterogeneity of marker expression in B-cell leukemias and its diagnostic significance.
abstract: Lymphoproliferative disorders of B-cell origin are identified by surface immunoglobulin markers. Clinically, these include several types of leukemias and lymphomas. We have attempted to further characterize B-cell leukemias immunologically using monoclonal antibodies Leu-1 and FMC-7. While cases of classical B-CLL have been shown to react with Leu-1 monoclonal, most other B-cell leukemias often do not react with Leu-1. Our results show that use of an additional monoclonal FMC-7 does not contribute towards diagnostic reliability.
authors.forename: M
authors.initials: M
authors.lastname: Menon
authors.forename: H G
authors.initials: HG
authors.lastname: Drexler
authors.forename: J
authors.initials: J
authors.lastname: Minowada
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007938:Leukemia / Q000175:diagnosis / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D000954:Antigens, Surface