title: Brain regional [3H]flunitrazepam binding in rats chronically treated with bupropion or B.W.306U.
abstract: After 21 days of twice daily i.p. injections of bupropion (10 mg/kg), B.W.306U (10 mg/kg) or saline, 5 rat brain regions were removed for [3H]flunitrazepam binding assay. Scatchard analysis of the binding data revealed no change in the Bmax in any brain regions in drug-treated rats compared to controls. There was, however, a significant change in the Kd value in the limbic forebrain of B.W.306U-treated rats.
authors.forename: T M
authors.initials: TM
authors.lastname: Smith
authors.forename: A S
authors.initials: AS
authors.lastname: Perumal
authors.forename: R F
authors.initials: RF
authors.lastname: Suckow
authors.forename: T B
authors.initials: TB
authors.lastname: Cooper
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D016642:Bupropion / Q000031:analogs & derivatives; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D005445:Flunitrazepam / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D008032:Limbic System / Q000378:metabolism; D008297:Male; D011427:Propiophenones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011427:Propiophenones; D016642:Bupropion; D005445:Flunitrazepam; C048735:BW 306U