Fe-dependent formation of a protein that makes mitochondria lipoxygenase-susceptible during maturation of reticulocytes.
During in vitro incubation the mitochondria of immature reticulocytes fail to be degraded by lipoxygenase and subsequent ATP-dependent proteolysis. Susceptibility is conferred on the mitochondria by a protein, the 'mitochondria susceptibility factor' which is synthesized during maturation of the reticulocytes in an iron-containing medium.
Rapoport
S
S
Schmidt
J
J
Prehn
S
S
D000818:Animals; D002118:Calcium / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology*; D008084:Lipoxygenase / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D014176:Protein Biosynthesis; D011817:Rabbits; D012156:Reticulocytes / Q000378:metabolism*
D003513:Cycloheximide; D007501:Iron; D008084:Lipoxygenase; D002118:Calcium