Mixed-ligand complexes of platinum(II) as curing agents for pBR322 and pBR329 (ColE1) plasmids in Escherichia coli.
The mixed-ligand complexes of platinum(II) [Pt(Gly)(uracil)Cl2].H2O and [Pt(His)(adenine)]-Cl.2H2O eliminated multicopy plasmids with the ColE1 origin of replication in Escherichia coli with 100% frequency. However, plasmids of the IncF1, H1 and X groups were totally refractory to these agents under similar conditions.
Lakshmi
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I. Department of Microbiology, Osmania University, Andhra Pradesh, India.
Sridhar
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Khan
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Polasa
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H
D004926:Escherichia coli; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D010957:Plasmids / Q000187:drug effects*
D008024:Ligands; D009944:Organoplatinum Compounds; C059575:histidinatoadenine platinum(II); C059574:dichloroglycineuracil platinum(II)