Electron microscopy proves Jo-1 antigen to be predominantly cytoplasmic but also nuclear.
The Jo-1 antigen is a specific marker for autoimmune myositis with an excellent correlation with associated interstitial lung disease. Using an electron microscopy immunogold technique, we were able to show that the antigen was predominantly cytoplasmic.
Thiry
M
M
Laboratoire d'Histologie, Université de Liège, Belgium.
Humbel
R
R
Dicato
M
M
Goessens
G
G
Meyers
R
R
Ries
F
F
D000604:Amino Acyl-tRNA Synthetases / Q000032:analysis*; D002467:Cell Nucleus / Q000276:immunology; D003593:Cytoplasm / Q000276:immunology* / Q000648:ultrastructure; D005260:Female; D006643:Histidine-tRNA Ligase / Q000032:analysis*; D006801:Humans; D007158:Immunologic Techniques; D008854:Microscopy, Electron; D008875:Middle Aged; D009220:Myositis / Q000276:immunology; D012595:Scleroderma, Systemic / Q000276:immunology
D000604:Amino Acyl-tRNA Synthetases; D006643:Histidine-tRNA Ligase