title: Treatment of Crohn's disease in relapse with cyclosporin A.
abstract: It has been suggested that cyclosporin A might be of some benefit to patients with Crohn's disease. The clinical response and side-effects of cyclosporin A in Crohn's disease are described in a series of 13 adults. The majority of patients had ileal disease and all but one were started on an initial oral dose of 15 mg/kg per day. Duration of treatment ranged from 3 to 42 weeks. Of the 13 patients, 6 showed a response to therapy; the remainder showed no response or deteriorated. The commonest side-effect was hyperaesthesia, but one patient developed nephrotoxicity and one developed hepatotoxicity. Significant drug malabsorption occurred in one case. The side-effects were dose dependent and reversible. Cyclosporin A may have a part to play in the treatment of resistant Crohn's disease, and in our hands has been associated with a 46 per cent response rate; however, the precise role of cyclosporin A in the management of Crohn's disease awaits further study.
authors.affiliation: Department of Surgery, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
authors.forename: N R
authors.initials: NR
authors.lastname: Parrott
authors.forename: R M
authors.initials: RM
authors.lastname: Taylor
authors.forename: C W
authors.initials: CW
authors.lastname: Venables
authors.forename: C O
authors.initials: CO
authors.lastname: Record
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D003424:Crohn Disease / Q000097:blood / Q000188:drug therapy*; D003524:Cyclosporins / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence
chemical_list: D003524:Cyclosporins