title: Effect of drug-induced taurine depletion on cardiac contractility and metabolism.
abstract: Myocardial taurine content was halved in rats maintained for 3 weeks on tap water containing either 1% guanidinoethylsulfonate (GES) or 3% beta-alanine. The decrease in taurine content did not affect myocardial contraction; however, it significantly altered myocardial metabolism. The major effect of the treatment was a significant stimulation in the rate of glycolysis and lactate production. The rise in glycolytic flux was associated with activation of phosphofructokinase, presumably caused by a decrease in tissue citrate levels. GES-treated hearts also contained slightly lower creatine phosphate content, but since this effect was not observed in the beta-alanine-treated hearts, it appeared to be independent of taurine depletion. The consequences of these metabolic changes are discussed.
authors.forename: M S
authors.initials: MS
authors.lastname: Mozaffari
authors.forename: B H
authors.initials: BH
authors.lastname: Tan
authors.forename: M A
authors.initials: MA
authors.lastname: Lucia
authors.forename: S W
authors.initials: SW
authors.lastname: Schaffer
mesh_terms: D000818:Animals; D006003:Glycogen / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D015091:beta-Alanine / Q000494:pharmacology
chemical_list: D007328:Insulin; D015091:beta-Alanine; D013654:Taurine; C009558:taurocyamine; D006003:Glycogen