Single-dose ceftriaxone therapy of gonococcal ophthalmia neonatorum.
Ceftriaxone (125 mg) given as a single intramuscular dose without topical therapy was evaluated in seven infants with smear-positive gonococcal ophthalmia neonatorum. Neisseria gonorrhoeae was isolated from the eyes of six infants, and four of these isolates were penicillinase-producing N. gonorrhoeae. Two infants had concomitant ocular infection with Chlamydia trachomatis. All seven infants, when seen at follow-up, showed marked clinical improvement. Conjunctivitis resolved completely in four infants. One infant was lost to subsequent follow-up, while two infants had persistent ophthalmia due to C. trachomatis. Follow-up eye cultures for N. gonorrhoeae were all negative.
Haase
D A
DA
Nash
R A
RA
Nsanze
H
H
D'Costa
L J
LJ
Fransen
L
L
Piot
P
P
Brunham
R C
RC
D002443:Ceftriaxone / Q000008:administration & dosage* / Q000627:therapeutic use; D002584:Cervix Uteri / Q000382:microbiology; D002986:Clinical Trials as Topic; D005123:Eye / Q000382:microbiology; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D009878:Ophthalmia Neonatorum / Q000188:drug therapy* / Q000382:microbiology
D002443:Ceftriaxone