A high amount of branched chain amino acids did not change favourable plasma albumin and protein concentrations during 48 hours post-laparotomy infusion--an experimental study in the rabbit.
The changes in plasma albumin and protein concentration during 48 hours post-laparotomy infusion of saline, 10% glucose alone and in combination with low (18%) and high (25%) concentration of branched chain amino acid solutions were investigated in the rabbit. During 24-hours post-laparotomy infusion of a solution with a low concentration of branched chain amino acids together with 10% glucose, the plasma albumin concentration decreases (15%) less than during infusion of a solution with a high concentration of branched chain amino acids together with 10% glucose (24%), saline (21%) or 10% glucose alone (23%). The amount of decrease in plasma albumin concentration 48 hours after laparotomy was independent of the four solution regimen used (between 20 to 23%). There is no favourable effect on plasma albumin and protein concentration from the use of high amounts of branched chain amino acids in 48 hours post-laparotomy infusion, whereas 24 hours infusion of a low concentration of branched chain amino acids is recommended.
Harju
E
E
D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D007700:Kinetics; D007813:Laparotomy; D010288:Parenteral Nutrition; D011817:Rabbits; D012709:Serum Albumin / Q000378:metabolism*
D000597:Amino Acids, Branched-Chain; D001798:Blood Proteins; D012709:Serum Albumin