EEG observations during combined haloperidol-lithium treatment.
Some reports have indicated a neurotoxic interaction of haloperidol and lithium, whereas others have not found this interaction. This is a report on two patients who showed both photomyoclonic and photoparoxysmal responses while on combined lithium-haloperidol treatment. We suggest that these findings, which have not been previously reported to be associated with combined lithium-haloperidol treatment, reflect neurotoxicity and that electroencephalogram (EEG) monitoring should be done on patients receiving this combined medication regimen.
Addy
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RO
Foliart
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RH
Saran
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AS
Schubert
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DS
D000328:Adult; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000139:chemically induced; D004828:Epilepsies, Partial / Q000139:chemically induced; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006220:Haloperidol / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D016651:Lithium Carbonate; D008297:Male; D010775:Photic Stimulation; D011618:Psychotic Disorders / Q000188:drug therapy*
D016651:Lithium Carbonate; D008094:Lithium; D006220:Haloperidol