[Molecular mechanisms of proteolytic processing of viral proteins and the problem of antiviral chemotherapy and vaccine design].
Proteolytic cleavage of virus-specific proteins is a universal phenomenon, which is widely expanded among different viruses including bacterial, plant, animal, and human viruses. Proteolytic processing of viral proteins involves the cleavage in strictly specific sites (proteolytic sites) of polyprotein molecules. Specificity of this processing is a doubly dependent event controlled by the amino acids of proteolytic sites and the presence of adequate proteinases. Host-originated and/or virus-coded proteinases are known to perform the cleavage of viral polypeptides. Conformational and functional behaviour of many virus proteins is regulated by proteolytic modification; as a result, the reproduction of mature virions and the infection pathways are directly controlled. Molecular mechanisms of site-specific proteolytic processing of viral proteins are proposed as a target to be attacked for chemotherapeutic virus inhibition and to be modified for vaccine design. The approaches are analysed to realise this antiviral strategy, and prospects for its development are discussed.
Zhirnov
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D000595:Amino Acid Sequence; D000998:Antiviral Agents; D006868:Hydrolysis; D008969:Molecular Sequence Data; D010447:Peptide Hydrolases / Q000378:metabolism*; D014612:Vaccines / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*; D014765:Viral Vaccines / Q000276:immunology*
D000998:Antiviral Agents; D014612:Vaccines; D014614:Vaccines, Synthetic; D014764:Viral Proteins; D014765:Viral Vaccines; D010447:Peptide Hydrolases
Molekuliarnye mekhanizmy proteoliticheskogo protsessinga virusnykh belkov i problema antivirusnoĭ khimioterapii i konstruirovaniia vaktsin.