Urinary excretion of albumin and retinol-binding protein in lithium-treated patients.
Urinary excretion of albumin and retinol-binding protein was measured by means of sensitive and specific immunochemical methods in a transverse study of 20 lithium-treated patients and 24 apparently healthy individuals. Albumin creatinine clearance ratios were significantly higher in the lithium-treated patients, which may indicate glomerular lesions. Microalbuminuria correlated highly to duration of lithium therapy. No significant difference between the retinol-binding protein creatinine clearance ratios in the two groups could be shown. This suggests that the catabolism of low-molecular-mass proteins in the proximal tubules was normal.
Jensen
H V
HV
Department B, Vordingborg Psychiatric Hospital, Denmark.
Holm
J
J
Hemmingsen
L
L
Thiesen
S
S
Andersen
J
J
D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000139:chemically induced*; D001714:Bipolar Disorder / Q000188:drug therapy*; D003404:Creatinine / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007684:Kidney Tubules / Q000187:drug effects; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012177:Retinol-Binding Proteins / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine
D012177:Retinol-Binding Proteins; D001613:beta 2-Microglobulin; D008094:Lithium; D003404:Creatinine