Autoantibody to human c-myc oncogene product in autoimmune patients' sera.
Sera from autoimmune diseases including systemic lupus erythematosus, dermatomyositis, progressive systemic sclerosis and Sjögren's disease, were examined for reactivity against human c-myc oncogene product. We first found the presence of the autoantibody to human c-myc oncogene product in sera from autoimmune diseases. No significant correlation between the presence of the anti-c-myc product antibody and disease activity, clinical disease types and other autoantibodies such as antinuclear factor, anti-DNA antibody, anti-RNP antibody and anti-Sm antibody were shown in this study.
Deguchi
Y
Y
Third Department of Internal Medicine, Osaka University School of Medicine, Japan.
Negoro
S
S
Kishimoto
S
S
D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000235:genetics / Q000378:metabolism*; D003882:Dermatomyositis / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000276:immunology*; D016271:Proto-Oncogene Proteins c-myc; D011519:Proto-Oncogenes; D012595:Scleroderma, Systemic / Q000235:genetics / Q000378:metabolism; D012859:Sjogren's Syndrome / Q000235:genetics / Q000378:metabolism
D001323:Autoantibodies; D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc