title: Adrenal and vascular renin-like activity in chronic 'two-kidney, one-clip' hypertensive rats.
abstract: In order to study the vascular and adrenal renin angiotensin system in the chronic phase (4 months after clipping) of 'two-kidney, one-clip' hypertension in rats, systolic blood pressure, plasma renin activity, and tissue renin-like activity in both aorta and adrenal have been measured. Renin activity in adrenal gland was studied in both the zona glomerulosa (GLO) and the remainder of the gland. Results showed an increase in vascular renin activity in chronic hypertensive rats. Moreover it was found that GLO of hypertensive rats presented a significant increase in renin-like activity compared with controls (349.43 +/- 43.86 versus 167 +/- 34.25 ng AI/g/20 h, p less than 0.01) and the fasciculata-reticular-medullar (FRM) portion also showed greater renin activity (345.16 +/- 64.36 versus 57.90 +/- 4.83 ng AI/g/20 h, p less than 0.01). The higher levels of vascular and FRM renin-like activity in chronic renal hypertension are probably a consequence of plasma renin increase. This hypothesis is supported by the fact that bilateral nephrectomy in normal rats induces a significant decrease in plasma renin activity and both aortic and FRM renin-like activity. On the other hand the GLO renin-like activity could depend on both plasma renin and local synthesis since bilateral nephrectomy induces an increase in the renin-like activity in this tissue. These data support the idea that aortic and FRM renin are, at least in part, due to plasma renin uptake and GLO renin is an autonomic system.
authors.affiliation: Departamento de Fisiologia, Facultad de Medicina, Murcia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Ubeda
authors.forename: I
authors.initials: I
authors.lastname: Hernandez
authors.forename: F J
authors.initials: FJ
authors.lastname: Fenoy
authors.forename: T
authors.initials: T
authors.lastname: Quesada
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001794:Blood Pressure; D006977:Hypertension, Renal / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008297:Male; D051381:Rats; D012083:Renin / Q000097:blood / Q000378:metabolism*; D012084:Renin-Angiotensin System
chemical_list: D012083:Renin