[Pregnancies following kidney transplantation--clinical problems and genetic studies].
Successful transplantations of the kidney by means of the medical rehabilitation also improve the reproductive rehabilitation of the young patients with distinct wish for children. In these cases the increased infectious, genetic, rejection and tumour risks as well as a limited transplant survival time require particular consideration. On 15 pregnancies among 151 patients in the Regional Dispensary for Patients who underwent kidney transplantations in Halle the clinical and genetic problems are discussed. A patient with preexisting risk factors under interdisciplinary intensive care bore a healthy child who is now 10 years old. The mother is still alive 12 years after the transplantation. Studies on 6 pregnancies in 3 patients who underwent a transplantation revealed 1 normal delivery and 5 interruptions for somatic and genetic indications. 2 female patients are alive 5 and 12 years after transplantation, 1 female patient again undergoes dialysis. From 9 pregnancies by 8 fathers who underwent transplantation 8 children were born (4-10 years) and 1 interruption had to be made. 4 patients live in the 8th to 11th year with the first transplant and 1 patient lives with the second transplant for 8 years. 4 patients again underwent dialysis, one patient died. Human-genetic problems are existing in the autosomal-recessively hereditary Alport-syndrome by the daughter as gene-carrier. 15 analyses of chromosomes on 396 investigated mitoses resulted in chromosomal break rates of 2, 4.7 and 5% in three children at the end of the second year of age, in the mother of 7% in the 4th year and in 2 fathers of 4 and 22% in the 4th and 5th year after transplantation.(ABSTRACT TRUNCATED AT 250 WORDS)
Koall
W
W
Nephrologischen Abteilung, Martin-Luther-Universität Halle-Wittenberg.
Müller
R
R
D000328:Adult; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007223:Infant; D007231:Infant, Newborn; D007621:Karyotyping; D007674:Kidney Diseases / Q000235:genetics* / Q000601:surgery; D007676:Kidney Failure, Chronic / Q000235:genetics / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D009394:Nephritis, Hereditary / Q000235:genetics; D010375:Pedigree; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*
D007166:Immunosuppressive Agents
Schwangerschaften nach Nierentransplantation--klinische Problematik und genetische Untersuchungen.