[Effect of 300 mg of ranitidine, 800 mg of cimetidine and a placebo administered after the evening meal on 24-hour gastric pH in patients with duodenal ulcer].
Twenty-four-hour intragastric pH monitoring was performed in 20 patients with duodenal ulcer in order to compare the results obtained with placebo, ranitidine 300 mg and cimetidine 800 mg administered one hour (7 PM) after evening meal (6 PM). During each 24 h period (8 AM-8 AM), gastric pH was continuously monitored in standardized dietary conditions. Treatment was started the evening (7 PM) before the test. Median acidity was calculated and percent of time of recording at or above any pH unit was graphically represented. Median acidity and areas under the curves were submitted to statistical comparison. The values were computed for the 24-h period, for the 8 AM-8 PM period, for the 8 PM-8 AM period. In these three periods studied gastric acidity decreased more with ranitidine than with cimetidine. No statistical difference was found between cimetidine and placebo for the 8 AM-8 PM period.
Pestiaux
A
A
Département Universitaire de Gastroentérologie, Université Libre de Bruxelles, Hôpital civil de Charleroi, Belgique.
Ooghe
P
P
Piérard
P
P
Van Cauter
J
J
Ligny
G
G
D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000188:drug therapy*; D004435:Eating; D005260:Female; D005744:Gastric Acid / Q000187:drug effects*; D005745:Gastric Acidity Determination; D006801:Humans; D008297:Male; D008875:Middle Aged; D011899:Ranitidine / Q000494:pharmacology*; D013997:Time Factors
D002927:Cimetidine; D011899:Ranitidine
Effet de 300 mg de ranitidine, de 800 mg de cimétidine et d'un placebo administrés après le repas du soir sur le pH gastrique de 24 heures chez l'ulcéreux duodénal.