Polyclonal B-cell stimulative and immunosuppressive activities at different developmental stages of Trypanosoma gambiense.
Bloodstream trypomastigote and cultured procyclic (insect midgut) forms of a monomophic strain of Trypanosoma gambiense were tested for their abilities to induce polyclonal B-cell activation (PBA) and immunosuppression (IS) in mice. Injection of a cell homogenate of bloodstream trypomastigotes induced both PBA and IS, while neither PBA nor IS was observed in mice injected with a cell homogenate of cultured procyclics. The results indicate that the substance(s) inducing PBA or IS is related to the developmental stage of the parasites.
Oka
M
M
Department of Parasitology, School of Medicine, University of Tokushima.
Yabu
Y
Y
Ito
Y
Y
Takayanagi
T
T
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D051379:Mice; D014347:Trypanosoma brucei gambiense / Q000254:growth & development / Q000276:immunology*