Absence of the RT-6 T cell subset in diabetes-prone BB/W rats.
Diabetes-prone Bio-breeding/Worcester (DP) rats exhibit a severe T cell lymphopenia and autoimmune pancreatic insulitis. The present results indicate that the T cell lymphopenia is due in large part, if not entirely, to the absence of the RT-6+ peripheral T cell subset, which includes members of both the helper/inducer (W3/25) and suppressor/cytotoxic (OX 8) antigenic phenotypes. Delineation of the causal mechanism(s) for the selective absence of RT-6+ T cells in DP rats may provide important insights into the cellular basis of the insulin-dependent diabetes mellitus syndrome in these animals.
Greiner
D L
DL
Handler
E S
ES
Nakano
K
K
Mordes
J P
JP
Rossini
A A
AA
D000818:Animals; D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000032:analysis / Q000276:immunology; D001323:Autoantibodies / Q000096:biosynthesis; D002454:Cell Differentiation; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D005260:Female; D006649:Histocompatibility Antigens / Q000032:analysis / Q000235:genetics / Q000276:immunology*; D007113:Immunity, Innate; D007958:Leukocyte Count; D008231:Lymphopenia / Q000235:genetics / Q000276:immunology; D008297:Male; D010641:Phenotype; D051381:Rats; D011913:Rats, Inbred BB / Q000276:immunology*; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains / Q000276:immunology*; D011920:Rats, Inbred WF; D013154:Spleen / Q000473:pathology; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology / Q000473:pathology
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D001323:Autoantibodies; D006649:Histocompatibility Antigens; C038353:histocompatibility antigens RT, rat