The effect of repeated administration of (-) deprenyl on the phenylethylamine-induced stereotypy in rats.
Phenylethylamine (PEA) in a dose of 40 mg/kg induces a moderate and short-lasting stereotype behaviour. The intensity and duration of PEA-induced stereotypy was strongly potentiated in rats with single selective doses of (-) deprenyl and J-508 (0.25 and 0.1 mg/kg s.c., respectively), which inhibit selectively the B form of MAO. Neither the increase of the single dose nor the daily administration of the selective doses of (-) deprenyl and J-508 for eight weeks caused a more intense or longer lasting potentiation of the PEA effect than single small dose of these drugs. Stopping administration of MAO-B inhibitors, normal sensitivity towards PEA returned after 3-4 weeks, in a parallel way with the recovery of MAO-B activity in the brain. Clorgyline, the selective inhibitor of MAO-A failed to influence the effect of PEA (0.25-2 mg/kg s.c.). The data support the view that the strong potentiation of the stimulatory effects of endogenous PEA via inhibition of its metabolism by (-) deprenyl may play a role in the antidepressant effect of this drug in man.
Timár
J
J
Knoll
B
B
D000480:Alkynes / Q000494:pharmacology; D000818:Animals; D003010:Clorgyline / Q000494:pharmacology; D005260:Female; D007189:Indans / Q000494:pharmacology; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D010293:Pargyline / Q000031:analogs & derivatives*; D010627:Phenethylamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012642:Selegiline / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects*
D000480:Alkynes; D007189:Indans; D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; D012642:Selegiline; C025253:N-methyl-N-propargyl-(1-indanyl)-ammonium hydrochloride; D010293:Pargyline; D003010:Clorgyline