Intracellular free Ca2+ in platelets of essential hypertensive patients. Lack of correlation with clinical and laboratory data.
Platelet intracellular free Ca2+, [Ca2+]i, was found to be higher in 64 hypertensive patients than in 65 age- and sex-matched normotensive controls (142.7 +/- 3.8 nmol/l vs 126.6 +/- 2.4 nmol/l, M +/- SEM, respectively; P less than 0.001). No differences were observed in hypertensive patients in relation to age, duration of hypertension or severity of retinopathy, but a slight correlation was observed (r = 0.275, P less than 0.05) between platelet [Ca2+]i and systolic blood pressure. No correlations were found between platelet [Ca2+]i and plasma cholesterol, triglycerides, aldosterone or renin activity. These data appear to support the hypothesis that increased platelet [Ca2+]i in hypertensive patients is more likely to be related to a primary cellular abnormality than to activation by extrinsic humoral or vascular factors.
Lechi
C
C
Istituti di Clinica Medica e di Chimica e Microscopia Clinica, Università di Verona, Italy.
Sinigaglia
D
D
Corsato
M
M
Covi
G
G
Arosio
E
E
Lechi
A
A
D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood; D001792:Blood Platelets / Q000032:analysis*; D001794:Blood Pressure; D002118:Calcium / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D000450:Aldosterone; D002784:Cholesterol; D012083:Renin; D002118:Calcium