title: [The course of color vision in early diabetic retinopathy treated with Ginkgo biloba extract. A preliminary double-blind versus placebo study].
abstract: The therapeutic efficiency of the Ginkgo biloba extract was estimated in a double-blind trial, during a 6 months period, in 29 diabetic subjects with an early diabetic retinopathy evidenced by angiography, and associated with a blue-yellow dyschromatopsia. The functional criterion was the color vision evolution, studied by the Desaturated Panel D-15 and the 100-Hue Farnsworth test at the beginning of the trial and 6 months later. An improvement tendency was evidenced in subjects treated by Ginkgo biloba extract, and an aggravation in subjects with placebo, this improvement being statistically significative with the Desaturated Panel D-15 among subjects without retinal ischemia. These clinical results on visual function corroborate the pharmacological actions of Ginkgo biloba extract on diabetic retina.
authors.affiliation: Laboratoire de la Vision des Couleurs, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris.
authors.forename: P
authors.initials: P
authors.lastname: Lanthony
authors.forename: J P
authors.initials: JP
authors.lastname: Cosson
mesh_terms: D002986:Clinical Trials as Topic; D003118:Color Perception; D003930:Diabetic Retinopathy / Q000188:drug therapy*; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use; D011897:Random Allocation; D013997:Time Factors
chemical_list: D010936:Plant Extracts
vernacular_title: Evolution de la vision des couleurs dans la rétinopathie diabétique débutante traitée par extrait de Ginkgo biloba. Etude préliminaire à double insu contre placebo.