[Effect of a single ethanol administration on the permeability of the hemato-encephalic barrier for 14C-tyrosine, 14C-DOPA and horseradish peroxidase].
Single injection of ethanol at a dose of 2 and 4 g/kg has been shown to increase blood-brain barrier penetration for peripherally administered 14C-tyrosine and 14C-DOPA. No changes in blood-brain barrier penetration for horseradish peroxidase has been found. Acute effect of ethanol on blood-brain barrier systems of specific and nonspecific transport is discussed.
Burov
Iu V
IuV
Borisenko
S A
SA
Kiianmaa
K
K
Lehtosalo
J
J
Mannisto
P
P
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002230:Carbidopa / Q000494:pharmacology; D002250:Carbon Radioisotopes; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004295:Dihydroxyphenylalanine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D006735:Horseradish Peroxidase / Q000378:metabolism*; D008297:Male; D010544:Peroxidases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014443:Tyrosine / Q000378:metabolism*
D002250:Carbon Radioisotopes; D000431:Ethanol; D014443:Tyrosine; D004295:Dihydroxyphenylalanine; D006735:Horseradish Peroxidase; D010544:Peroxidases; D002230:Carbidopa
Vliianie odnokratnogo vvedeniia étanola na pronitsaemost' gemato-éntsefalicheskogo bar'era dlia 14C-tirozina, 14C-DOFA i peroksidazy khrena.