Combined pharmacokinetic/pharmacodynamic (PK/PD) modeling.
Several compartmental and noncompartmental approaches have been successfully applied to PK/PD modeling. Although great opportunities exist to expand on these techniques, application of these methods to relate concentrations of all drugs to their effects is possible.
Colburn
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Pharmacokinetics/Drug Metabolism Department, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.
D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D010600:Pharmacology