Lowered glutathione-peroxidase activity in asthmatic patients with food and aspirin intolerance.
In analogy with findings from animal experiments, people with low glutathione-peroxidase (GSH-Px) activity could be expected to have altered sensitivities to effects of drugs, chemicals and possibly food. We have investigated GSH-Px activity in 12 patients with intrinsic asthma and food and aspirin intolerance. Ten of the 12 patients had very low or low GSH-Px activity and the frequency of low GSH-Px activity in this group was statistically significant (P less than 0.001) compared with the control material of age- and sex-matched healthy individuals. Our finding of lowered GSH-Px activity in patients with aspirin intolerance may indicate the involvement of hitherto unknown mechanisms in the pathogenesis of asthmatic disorders.
Malmgren
R
R
Unge
G
G
Zetterström
O
O
Theorell
H
H
de Wahl
K
K
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001241:Aspirin / Q000009:adverse effects / Q000494:pharmacology; D001249:Asthma / Q000097:blood / Q000150:complications / Q000201:enzymology*; D001792:Blood Platelets / Q000201:enzymology / Q000502:physiology; D016861:Cyclooxygenase Inhibitors; D004342:Drug Hypersensitivity / Q000150:complications* / Q000201:enzymology; D005512:Food Hypersensitivity / Q000150:complications* / Q000201:enzymology; D005609:Free Radicals; D005979:Glutathione Peroxidase / Q000097:blood* / Q000502:physiology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D012643:Selenium / Q000172:deficiency / Q000502:physiology
D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D005609:Free Radicals; D016718:Arachidonic Acid; D005979:Glutathione Peroxidase; D011451:Prostaglandin-Endoperoxide Synthases; D012643:Selenium; D001241:Aspirin