title: [2 cases of Binswanger's disease not associated with arterial hypertension: clinical-instrumental and neuropsychological evaluation].
abstract: Two cases of subcortical arteriosclerotic encephalopathy (Binswanger's disease) are reported. The two patients lacked a clinical history of hypertension, relevant pathogenetic factor in the development of the small and medium size cerebral arteries atherosclerosis, which is the main pathologic finding of the disease. The two subjects clinically showed a marked intellectual deterioration, together with mood depression and focal neurological signs, that were an expression of the multifocal neurologic involvement. In both cases CT scans evidentiated a mainly periventricular leucoencephalopathy associated, in the first patient, with small multiple ischemic lesions and, in the second, with a unique hypodense area in the centrum semiovale. A review of the literature on the subjects is proposed, together with an attempt of pathogenetic interpretation of our two cases.
authors.affiliation: Istituto di Clinica Neurologica, Università, Perugia.
authors.forename: G
authors.initials: G
authors.lastname: Finali
authors.forename: M
authors.initials: M
authors.lastname: Piccirilli
authors.forename: G L
authors.initials: GL
authors.lastname: Piccinin
authors.forename: E
authors.initials: E
authors.lastname: Stefano
authors.forename: G
authors.initials: G
authors.lastname: Tilia
authors.forename: G A
authors.initials: GA
authors.lastname: Amabile
authors.forename: C
authors.initials: C
authors.lastname: Morocutti
mesh_terms: D003704:Dementia / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000150:complications; D002537:Intracranial Arteriosclerosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D014057:Tomography, X-Ray Computed
vernacular_title: Su due casi di malattia di Binswanger non associata ad ipertensione arteriosa: valutazione clinico-strumentale e neuropsicologica.