title: Multicentre study of the efficacy and tolerance of acebutolol versus atenolol in the long term treatment of mild arterial hypertension.
abstract: The efficacy, tolerance and effect on serum lipids of acebutolol were compared with those of atenolol over a 6-month period in a large group of patients with mild arterial hypertension. Both drugs were equally effective in reducing blood pressure, and tolerance was generally excellent. High density lipoprotein (HDL)-cholesterol concentrations were reduced to a similar extent by both treatments at 2 months and this change was reflected in measurements of the total cholesterol concentrations. However, no significant changes occurred in serum triglyceride levels and at 6 months all serum lipid parameters had returned to baseline values. These observations suggest that cardioselective beta-blockers have no adverse effects on serum lipids at 6 months, after a temporary reduction of HDL-cholesterol at 2 months.
authors.affiliation: Department of Hygiene and Social Medicine, University Hospital, Ghent, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: De Backer
mesh_terms: D000070:Acebutolol / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D001262:Atenolol / Q000009:adverse effects / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides; D001262:Atenolol; D000070:Acebutolol; D002784:Cholesterol