[Effect of bacterial endotoxin on the respiratory function of liver mitochondria].
It is shown that LD50 of bacterial endotoxin exerts an uncoupling effect on the mouse liver mitochondria. The effect of endotoxin is observed 3 h after its administration. Direct addition of endotoxin to isolated mitochondria has induced a rotenone-like effect and an uncoupling action when using succinate as a substrate of oxidation.
Natanzon
L V
LV
D000818:Animals; D004731:Endotoxins / Q000633:toxicity*; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D012486:Salmonella typhimurium
D004731:Endotoxins
Vliianie bakterial'nogo éndotoksina na dykhatel'nuiu funktsiiu mitokhondriĭ pecheni.