Central noradrenaline depletion antagonizes aspects of d-amphetamine-induced hyperactivity in the rat.
The effects of noradrenaline (NA) depletion upon amphetamine-induced hyperactivity were examined in five experiments. Central NA depletion via either systemic DSP4 or neonatal 6-OHDA antagonised the amphetamine-induced (2 mg/kg SC) increase in rearing behaviour, whereas lesions of the dorsal noradrenergic bundle using 6-hydroxydopamine antagonised the increase in locomotor activity. Peripheral NA depletion following systemic 6-hydroxydopamine to adult rats did not cause any changes in motor activity after acute amphetamine administration. Desipramine, the selective NA uptake inhibitor, blocked the effects of DSP4 upon amphetamine-induced rearing. NA depletion antagonised hyperactivity produced by the 2 mg/kg dose of amphetamine, but not the hyperactivity (rearing or locomotion) effects of amphetamine at 1, 4 or 8 mg/kg.
Archer
T
T
Fredriksson
A
A
Jonsson
G
G
Lewander
T
T
Mohammed
A K
AK
Ross
S B
SB
Söderberg
U
U
D000818:Animals; D001596:Benzylamines / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology; D003891:Desipramine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology*; D004347:Drug Interactions; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009638:Norepinephrine / Q000502:physiology*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains
D001596:Benzylamines; D006892:Hydroxydopamines; D016627:Oxidopamine; C012102:DSP 4; D003891:Desipramine; D003913:Dextroamphetamine; D009638:Norepinephrine