[Oncogenes and bronchial cancer].
Oncogenes are genes for malignant transformation which correspond to changes, by genetic mutation, of genes which are present in all normal eukaryotic cells, called proto-oncogenes. The latter are involved in physiological functions often controlling growth and cell differentiation. Their mechanism of action and the activation of oncogenes are successively anticipated. These oncogenes are implicated in the majority of cancers and in particular in bronchial carcinoma: the myc-oncogenes (c-myc, N myc, L myc) are primarily activated in small cell carcinomas (CPC), the Ras genes (Ki Ras, Ha Ras) in epidermoid and adeno carcinomas. The intervention of growth factors such as bombesin in CPC and of their receptors such as epithelial growth factor (EGF) in non small cell bronchial carcinomas has been shown, as well as the role of cytogenic abnormalities (deletion of the short arm of chromosome 3). Their relation to oncogenes is discussed. The knowledge acquired on oncogenes in bronchial carcinoma should shed light on the pathogenesis of these cancers and find its next application in the diagnostic, prognostic and therapeutic field.
Brambilla
E
E
Service d'Anatomie Pathologique, C.H.R. de Grenoble.
Wuyam
B
B
Brambilla
C
C
D001984:Bronchial Neoplasms / Q000235:genetics; D002277:Carcinoma / Q000235:genetics*; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D009857:Oncogenes
Oncogènes et cancers bronchiques.