title: The behavioral actions of diazepam and oxazepam are similar.
abstract: In a double-blind and randomized study, we assessed the comparative pharmacodynamic profiles and behavioral effects of diazepam and oxazepam administered to young healthy volunteers. Diazepam 0.3 mg/kg or oxazepam 1.2 mg/kg or placebo were each administered orally to 13 subjects who were tested with tasks which measured learning and memory, cognition, psychomotor performance and mood before and for 9 h after treatment. The two drugs had similar actions, although subjective effects were milder after oxazepam, which also had a slower onset of action. There was no evidence of rebound behavioral impairment.
authors.forename: S P
authors.initials: SP
authors.lastname: Mewaldt
authors.forename: M M
authors.initials: MM
authors.lastname: Ghoneim
authors.forename: J V
authors.initials: JV
authors.lastname: Hinrichs
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect / Q000187:drug effects; D001519:Behavior / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D011939:Mental Recall / Q000187:drug effects; D010076:Oxazepam / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D011897:Random Allocation
chemical_list: D010076:Oxazepam; D003975:Diazepam