Effect of budesonide on pulmonary hyperinflation in young asthmatic children.
In 19 asthmatic children, aged 2-6 years, the effect of six weeks' treatment with inhaled budesonide or placebo on functional residual capacity (FRC--helium dilution) and bronchodilator responsiveness was assessed in a double blind, randomised crossover trial. FRC was increased in most children at the start of treatment. Treatment with budesonide was associated with a reduction in FRC by comparison with placebo (median change 9% v 0%; p less than 0.05). There was a trend towards a greater response to a bronchodilator after budesonide. The results suggest that inhaled corticosteroids reduce hyperinflation in young asthmatic children.
Greenough
A
A
Paediatric Respiratory Laboratory, King's College Hospital, London.
Pool
J
J
Gleeson
J G
JG
Price
J F
JF
D000403:Airway Resistance / Q000187:drug effects; D001249:Asthma / Q000188:drug therapy*; D019819:Budesonide; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005652:Functional Residual Capacity; D006801:Humans; D008168:Lung / Q000187:drug effects; D011282:Pregnenediones / Q000627:therapeutic use*; D011897:Random Allocation
D011282:Pregnenediones; D019819:Budesonide