title: Thyrotropin releasing hormone levels in human cerebrospinal fluid in various neurologic diseases.
abstract: Thyrotropin releasing hormone (TRH) in the human cerebrospinal fluid (CSF) of 102 patients with non-neurologic and neurologic diseases was measured by a specific TRH radioimmunoassay. TRH levels in CSF were 17.6 +/- 3.4 pg/ml (mean +/- SE) in non-neurologic diseases. TRH levels in CSF were significantly elevated in cases of spinal cord tumor and multiple sclerosis (acute phase). Elevated TRH levels in CSF were decreased in these diseases by operation or prednisolone treatment, respectively. From these data, it is suggested that TRH is present in the human CSF and that measurement of TRH levels in CSF may be a useful indicator of the activity of certain neurologic diseases.
authors.forename: T
authors.initials: T
authors.lastname: Mitsuma
authors.forename: T
authors.initials: T
authors.lastname: Nogimori
authors.forename: K
authors.initials: K
authors.lastname: Sahashi
authors.forename: K
authors.initials: K
authors.lastname: Adachi
authors.forename: M
authors.initials: M
authors.lastname: Kihara
authors.forename: K
authors.initials: K
authors.lastname: Murakami
authors.forename: N
authors.initials: N
authors.lastname: Nakao
authors.forename: M
authors.initials: M
authors.lastname: Gonda
authors.forename: K
authors.initials: K
authors.lastname: Fujii
authors.forename: Y
authors.initials: Y
authors.lastname: Okabe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D011817:Rabbits / Q000276:immunology; D011863:Radioimmunoassay; D013120:Spinal Cord Neoplasms / Q000134:cerebrospinal fluid; D013973:Thyrotropin-Releasing Hormone / Q000134:cerebrospinal fluid*
chemical_list: D013973:Thyrotropin-Releasing Hormone