Amyloidosis secondary to gout. Identification with a monoclonal antibody to amyloid protein A.
A patient with amyloidosis secondary to polyarticular gout is presented in whom amyloid protein A (AA) was demonstrated in the kidney with a monoclonal antibody against protein A. The rarity of this association is discussed and a pathogenetic mechanism proposed.
Jacobelli
S
S
Department of Immunology, Universidad Catolica de Chile.
Vial
S
S
Rosenberg
H
H
Benson
M D
MD
Scheinberg
M A
MA
D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis*; D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D006073:Gout / Q000150:complications*; D006801:Humans; D007124:Immunoenzyme Techniques; D007668:Kidney / Q000032:analysis; D008297:Male; D008875:Middle Aged; D000685:Serum Amyloid A Protein / Q000032:analysis*
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D000685:Serum Amyloid A Protein