Chlorambucil overdose: accidental ingestion of an antineoplastic drug.
A 22-month-old, 10 kg child ingested 32 mg of chlorambucil and developed irritability, myoclonic-like muscle jerks, an exaggerated startle reflex, vomiting, and EEG changes within a few hours. The neurologic symptoms improved overnight, and the patient was discharged at about 28 hours postingestion. During the three weeks of follow-up, mild bone marrow suppression occurred and resolved. A normal EEG was reported at 33 weeks postingestion.
Vandenberg
S A
SA
Rocky Mountain Poison & Drug Center, Denver, Colorado 80204.
Kulig
K
K
Spoerke
D G
DG
Hall
A H
AH
Bailie
V J
VJ
Rumack
B H
BH
D000061:Accidents, Home; D002606:Charcoal / Q000627:therapeutic use; D002699:Chlorambucil / Q000506:poisoning*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D008278:Magnesium Sulfate / Q000627:therapeutic use; D012640:Seizures / Q000139:chemically induced
D002606:Charcoal; D002699:Chlorambucil; D008278:Magnesium Sulfate