title: [Study of the biotransformation of various antineoplastic agents using the Ames test].
abstract: The Ames test on indicator bacteria S. typhimurium TA 1950 and TA 100 and the differential spectrophotometry have shown that cytochrome P-450-dependent monooxygenases of mammalian liver participate in the metabolism of antitumour drugs (cyclophosphamide, thiophosphamide) and of nitrosomorpholine (promutagen). Data concerning prospidin indicate that microsomal liver enzymes either induce no metabolic transformations of this preparation or the formed metabolites possess the mutagenic activity similar to that of the parent compound.
authors.forename: N G
authors.initials: NG
authors.lastname: Oblapenko
authors.forename: A Z
authors.initials: AZ
authors.lastname: Prikhod'ko
authors.forename: L M
authors.initials: LM
authors.lastname: Fonshteĭn
authors.forename: V A
authors.initials: VA
authors.lastname: Chernov
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000633:toxicity; D001711:Biotransformation; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000493:pharmacokinetics*; D009154:Mutation; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D009153:Mutagens
vernacular_title: Issledovanie protsessov biotransformatsii nekotorykh protivoopukholevykh preparatov s pomoshch'iu testa Eĭmsa.