title: The history of Nolvadex.
abstract: The research programme leading to the discovery of Nolvadex (tamoxifen, ICI 46474) (2; R1 = Me, X = Et), the anti-oestrogen used widely in the treatment of breast cancer, is described by the chemist involved in the discovery.
authors.affiliation: Imperial Chemical Industries PLC, Macclesfield, Cheshire.
authors.forename: D N
authors.initials: DN
authors.lastname: Richardson
mesh_terms: D000818:Animals; D006801:Humans; D013629:Tamoxifen / Q000378:metabolism / Q000494:pharmacology
chemical_list: D013629:Tamoxifen