title: 5-FU/leucovorin: biochemical modulation that works?
abstract: Three cooperative groups are currently accruing patients to randomized Phase III studies of 5-FU plus leucovorin. These studies should provide data allowing more definitive conclusions regarding the therapeutic utility of this combination. Until results of these studies are available, 5-FU plus leucovorin (CF) remains an investigational treatment, not suitable for routine use.
authors.affiliation: Dept. of Surgical Oncology, State U of NY, Buffalo.
authors.forename: S G
authors.initials: SG
authors.lastname: Arbuck
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D009369:Neoplasms / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic
chemical_list: D002955:Leucovorin; D005472:Fluorouracil