title: Diagnostic uses of angiotensin-converting enzyme inhibitors in renovascular hypertension.
abstract: The response to angiotensin-converting enzyme inhibitors (ACEIs) can be of considerable help in the diagnosis of human renovascular hypertension (RVH) in three settings. First, a particularly dramatic antihypertensive response or a decline in glomerular filtration rate (GFR), as indexed by a rise in serum creatinine or blood urea nitrogen concentrations, are useful clues to the presence of renovascular hypertension. Second, an exaggerated rise in plasma renin activity (PRA) after short-term captopril administration is a very promising screening test for this condition. Third, ACEI-induced changes in single-kidney hemodynamics (assessed by renography) may be helpful in confirming the diagnosis and offers the prospect of localizing the ischemic kidney.
authors.affiliation: Department of Medicine, University of Florida College of Medicine, Gainesville.
authors.forename: C S
authors.initials: CS
authors.lastname: Wilcox
authors.forename: C M
authors.initials: CM
authors.lastname: Williams
authors.forename: T B
authors.initials: TB
authors.lastname: Smith
authors.forename: E D
authors.initials: ED
authors.lastname: Frederickson
authors.forename: C
authors.initials: C
authors.lastname: Wingo
authors.forename: C M
authors.initials: CM
authors.lastname: Bucci
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors; D006801:Humans; D006978:Hypertension, Renovascular / Q000175:diagnosis*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors