title: Comparative effects of diltiazem and glycerol trinitrate on isolated ureter and coronary artery of the dog.
abstract: Effects of diltiazem on isolated ureter and coronary artery of the dog were compared with those of glycerol trinitrate (GTN). Diltiazem (DZ) (10(-9)-10(-6) M) decreased the force and frequency of ureteral rhythmic contractions evoked by potassium or phenylephrine in a concentration-dependent manner, and relaxed potassium-contracted coronary artery strips. The dose dependence of the inhibitory effects of diltiazem was similar on the ureter and coronary artery. GTN (10(-7)-10(-5) M) also showed similar inhibitory effects, but these were more pronounced on the coronary artery than on the ureter.
authors.forename: M
authors.initials: M
authors.lastname: Sakanashi
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: J
authors.initials: J
authors.lastname: Nakasone
authors.forename: Y
authors.initials: Y
authors.lastname: Aniya
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D002118:Calcium / Q000037:antagonists & inhibitors / Q000378:metabolism; D003331:Coronary Vessels / Q000187:drug effects; D004110:Diltiazem / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D005996:Nitroglycerin / Q000494:pharmacology*; D010656:Phenylephrine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D014513:Ureter / Q000187:drug effects
chemical_list: D001552:Benzazepines; D010656:Phenylephrine; D004110:Diltiazem; D005996:Nitroglycerin; D011188:Potassium; D002118:Calcium