Staging and current treatments for endometrial cancer.
Patients with Stage I endometrial carcinoma need to be further subdivided into low or high risk for recurrence. Treatment consists of surgery, with or without pre- or postoperative radiation. The supposed advantages of preoperative radiation are questionable. Definitive treatment recommendations for Stage I can be made only for Stage IaG1, where surgery alone suffices. Stage II patients have a high survival (80-90%) if there is no spread beyond the uterus. Although doxorubicin is the most active chemotherapeutic agent, the response rate is low. Response to progesterone is high (30-40%), but complete responses of prolonged duration are few.
Homesley
H D
HD
Bowman Gray School of Medicine.
D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D011379:Prognosis; D014594:Uterine Neoplasms / Q000473:pathology* / Q000628:therapy; D014599:Uterus / Q000473:pathology