Lymph node macrophage heterogeneity: a subpopulation fails to express activation phenotype.
We have identified and characterised a subpopulation of macrophages in the rat lymph node. The stromal macrophage shows many characteristics not expressed by peritoneal macrophages; clustering of B cells, selective uptake of TI-2 antigens, failure to express surface Ia after activation. These differences are suggestive of a regulatory role in B cell rather than T cell function.
Chao
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Sir William Dunn School of Pathology, University of Oxford, England.
MacPherson
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GG
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology; D002448:Cell Adhesion; D005455:Fluorescent Antibody Technique; D006087:Graft vs Host Reaction; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D008198:Lymph Nodes / Q000166:cytology; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology* / Q000648:ultrastructure; D051381:Rats
D000949:Histocompatibility Antigens Class II