title: Dosage effects and individual responsivity to methylphenidate in attention deficit disorder.
abstract: Effects of three dosages of methylphenidate (0.15, 0.30 and 0.60 mg/kg) were assessed in 19 ADD-H children on a variety of cognitive, academic and behavioral measures in the laboratory and the classroom. A predominant linear pattern of improvement was found across almost all measures. A slight decrease between 0.3 and 0.6 mg/kg on one cognitive task leaves open the possibility that higher dosages reduce stimulant effectiveness or cause decrements on some kinds of "high-level/high load" tasks. Response patterns of individual children varied considerably across measures. All children improved on at least several measures. Results were interpreted as evidence for stimulant activation of self-regulatory processes.
authors.affiliation: Department of Psychology, McGill University--Montreal Children's Hospital Research Institute, Canada.
authors.forename: V I
authors.initials: VI
authors.lastname: Douglas
authors.forename: R G
authors.initials: RG
authors.lastname: Barr
authors.forename: K
authors.initials: K
authors.lastname: Amin
authors.forename: M E
authors.initials: ME
authors.lastname: O'Neill
authors.forename: B G
authors.initials: BG
authors.lastname: Britton
mesh_terms: D001288:Attention / Q000187:drug effects; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage*; D011581:Psychological Tests
chemical_list: D008774:Methylphenidate