Animal models of alopecia.
A genetic model of androchronogenic alopecia has yet to be described in the rat or mouse, two of the better characterized species. It may be relevant that the best current animal model of androchronogenic alopecia, the stumptailed macaque, is a primate. The age of onset and the pattern of hair loss closely resemble human male-pattern baldness and morphologically, as well as mechanistically, may be analogous to the corresponding process in humans. Since genetically controlled regional hairlessness is a phenomenon relatively unique to Homo sapiens, it may be too much to expect to find an analogous process among rodents.
Holland
J M
JM
Section on Pathology and Toxicology Research, Upjohn Company, Kalamazoo, Michigan.
D000505:Alopecia / Q000209:etiology / Q000235:genetics*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006197:Hair / Q000254:growth & development; D008297:Male; D051379:Mice; D008914:Minoxidil / Q000008:administration & dosage / Q000494:pharmacology; D009154:Mutation; D051381:Rats; D012867:Skin / Q000473:pathology
D008914:Minoxidil