[The significance of gene expression and post-translational modifications of collagen for the origin of fibrosis].
An account is given in this paper of processes relating to molecular and cellular biology in collagen synthesis, with reference being made to autoradiographic evidence to secretion of 3H-proline containing precursors of collagen fibre from fibroblasts of granulation tissue into extracellular space. Findings made in this context in the wake of in situ hybridisation have shown collagenisation to be regulated primarily by gene expression rather than by post-translational modifications. Reference is made to new possible approaches to the control of fibrosis and sclerosis, resulting from knowledge of molecular biological foundations and principles underlying collagen synthesis.
Kunz
J
J
Institut für Pathologische Anatomie, Bereiches Medizin (Charité), Humboldt-Universität zu Berlin, DDR.
Fetzer
R
R
D000818:Animals; D003094:Collagen / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D005355:Fibrosis; D005786:Gene Expression Regulation; D011499:Protein Processing, Post-Translational; D012598:Sclerosis
D003094:Collagen
Uber die Bedeutung von Genexpression und posttranslationalen Modifikationen des Kollagens für die Entstehung von Fibrosen.