Acquired pachydermatoglyphy. A cutaneous sign of internal malignancy.
A 70-year-old man with hypertrophic osteoartropathy secondary to a squamous cell carcinoma of the lung presented a distinctive pattern of late-onset bilateral palmar keratoderma. A yellowish rugose appearance with accentuation of normal ridges and sulci (pachydermatoglyphy) involving the palms was observed. The differential diagnosis and the clinical relevance of acquired pachydermatoglyphy as a cutaneous marker of internal malignancy are discussed.
Pujol
R M
RM
Department of Dermatology, Hospital Sant Pau, Barcelona, Spain.
Puig
L
L
García-Marques
J M
JM
de Moragas
J M
JM
D000052:Acanthosis Nigricans / Q000209:etiology; D000368:Aged; D001984:Bronchial Neoplasms / Q000150:complications*; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D003878:Dermatoglyphics; D003937:Diagnosis, Differential; D004604:Elephantiasis / Q000209:etiology*; D005260:Female; D006229:Hand Dermatoses / Q000209:etiology*; D006801:Humans; D008209:Lymphedema / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010004:Osteoarthropathy, Primary Hypertrophic / Q000175:diagnosis / Q000209:etiology