Carbamazepine, phenytoin and phenobarbital in drug-resistant partial epilepsies.
96 monotherapies with carbamazepine, phenytoin, phenobarbital and primidone were assessed in 42 patients with partial epilepsy. Those whose seizure frequency was reduced by 75% or more were considered to have improved. In 54 comparisons of monotherapies significant improvement in seizure frequency was achieved in only 16.7% of cases. Nonresponding patients showed practically no change across all comparisons according to the Fischer test.
Cornaggia
C M
CM
Canevini
M P
MP
Giuccioli
D
D
Pruneri
C
C
Canger
R
R
D000293:Adolescent; D000328:Adult; D002220:Carbamazepine / Q000627:therapeutic use*; D004341:Drug Evaluation; D004351:Drug Resistance; D004828:Epilepsies, Partial / Q000188:drug therapy*; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000627:therapeutic use*; D010672:Phenytoin / Q000627:therapeutic use*; D011324:Primidone / Q000627:therapeutic use
D011324:Primidone; D002220:Carbamazepine; D010672:Phenytoin; D010634:Phenobarbital