title: The presence of serotonin-immunoreactive nerve fibers in the optic nerve of the mouse.
abstract: Serotonin immunoreactivity was investigated in the optic nerve of the mouse by use of mono- and polyclonal antisera and the indirect peroxidase-antiperoxidase technique. A number of serotonin-immunoreactive nerve fibers with beaded appearance were demonstrated mainly orientated along its longitudinal axis. Since several studies have failed to demonstrate perikarya immunoreactive to serotonin in the mammalian retina, the presence of serotoninergic fibers in the optic nerve further supports a retinopetal innervation.
authors.affiliation: Department B, University of Copenhagen, Denmark.
authors.forename: J D
authors.initials: JD
authors.lastname: Mikkelsen
mesh_terms: D000818:Animals; D007124:Immunoenzyme Techniques; D008297:Male; D051379:Mice / Q000276:immunology*; D009412:Nerve Fibers / Q000166:cytology / Q000276:immunology*; D009474:Neurons / Q000276:immunology; D009897:Optic Chiasm / Q000166:cytology / Q000276:immunology; D009900:Optic Nerve / Q000166:cytology / Q000276:immunology*; D011903:Raphe Nuclei / Q000166:cytology / Q000276:immunology; D012701:Serotonin / Q000276:immunology*
chemical_list: D012701:Serotonin