Chemical stabilities of cefoperazone sodium and ceftazidime in 5% dextrose and 0.9% sodium chloride injections.
The chemical stabilities of cefoperazone and ceftazidime solutions in 5% dextrose and 0.9% sodium chloride injections have been studied using high-performance liquid chromatography methods. The solutions of cefoperazone were stable for 8 days (loss in potency of less than 10%) at 25 degrees C, for at least 80 days at 5 degrees C and for at least 96 days at -10 degrees C. The ceftazidime solutions were stable for only 2 days at 25 degrees C, for 21 days at 5 degrees C (28 days in normal saline) and for 90 days at -10 degrees C. Thawing the frozen solutions using a microwave oven did not cause degradation.
Das Gupta
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V
Department of Pharmaceutics, University of Houston, TX 77030.
Bethea
C
C
dela Torre
M
M
D002438:Cefoperazone; D002442:Ceftazidime; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D005947:Glucose; D006863:Hydrogen-Ion Concentration; D007267:Injections; D012965:Sodium Chloride; D012996:Solutions
D012996:Solutions; D012965:Sodium Chloride; D002438:Cefoperazone; D002442:Ceftazidime; D005947:Glucose