title: [Treatment of vasospasm in aneurysmal meningeal hemorrhage using intravenous nimodipine. Multicenter cooperative study].
abstract: We present a multicentric randomized double-blind study of the curative effect of intravenous Nimodipine on the post hemorrhagic vasospasm after aneurysmal rupture. On 122 validated cases out of 188 analyzed patients, the study demonstrates a significative effect on the mortality and severe morbidity related to vasospasm: the reduction of the risk is appreciated to 72%. The major effect is obtained on the mortality risk. A selective effect can be demonstrate on the isolated vasospasm.
authors.affiliation: Service de Neurochirurgie B, Centre Gui-de-Chauliac, Montpellier.
authors.forename: P
authors.initials: P
authors.lastname: Frerebeau
authors.forename: P
authors.initials: P
authors.lastname: Janny
authors.forename: G
authors.initials: G
authors.lastname: Taquoi
authors.forename: G
authors.initials: G
authors.lastname: Besson
authors.forename: F
authors.initials: F
authors.lastname: Buchheit
authors.forename: M
authors.initials: M
authors.lastname: Childs
authors.forename: J P
authors.initials: JP
authors.lastname: Houtteville
authors.forename: M
authors.initials: M
authors.lastname: Jan
authors.forename: M
authors.initials: M
authors.lastname: Jomin
authors.forename: J
authors.initials: J
authors.lastname: Pecker
mesh_terms: D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D002532:Intracranial Aneurysm / Q000150:complications*; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009553:Nimodipine / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D012422:Rupture, Spontaneous; D013345:Subarachnoid Hemorrhage / Q000150:complications*
chemical_list: D009553:Nimodipine
vernacular_title: Traitement curatif du vasospasme des hémorragies méningées d'origine anévrysmale par la nimodipine intraveineuse. Etude coopérative multicentrique.