Mechanisms of virus-induced demyelination and remyelination.
Viral models of demyelination and remyelination provide important clues to the pathogenesis of multiple sclerosis. Determining the precise viral polypeptides recognized by T cells during the demyelinating process will be important in understanding the mechanisms of viral-induced myelin destruction. Isolation, purification, and characterization of factors that promote remyelination and proliferation of oligodendrocytes may provide hope in the treatment of patients with chronic demyelinating disorders.
Rodriguez
M
M
Department of Neurology and Immunology, Mayo Clinic and Research Foundation, Rochester, Minnesota.
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D003588:Cytopathogenic Effect, Viral; D003711:Demyelinating Diseases / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D004769:Enterovirus Infections / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D004680:Maus Elberfeld virus; D051379:Mice; D009836:Oligodendroglia / Q000382:microbiology / Q000473:pathology; D014777:Virus Diseases / Q000150:complications* / Q000276:immunology / Q000473:pathology