Body fluid homeostasis in the newborn infant with congestive heart failure: effects of diuretics.
Congestive heart failure is characterized by extracellular fluid volume expansion, increased venous filling pressure, and paradoxal renal sodium retention. Although diuretics remain invaluable agents to lower venous pressure in congestive heart failure, they also carry the risk of further compromising cardiac output and inducing severe adverse effects. This article reviews the pathophysiology of body fluid homeostasis in neonates with congestive heart failure, and discusses the adverse effects associated with the use and abuse of diuretics.
Guignard
J P
JP
Department of Pediatrics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Gouyon
J B
JB
D001826:Body Fluids / Q000187:drug effects*; D004232:Diuretics / Q000627:therapeutic use*; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy / Q000503:physiopathology; D006333:Heart Failure / Q000188:drug therapy*; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn
D004232:Diuretics