Hypertension and diabetes mellitus: erythrocyte electrolytes and the effect of captopril treatment.
Erythrocyte sodium, potassium and water contents and sodium fluxes were measured in both normotensive and hypertensive patients with either insulin dependent or non-insulin dependent diabetes mellitus. Hypertensive patients were studied again after two months' treatment with captopril. There were no differences in erythrocyte ion contents or concentrations but sodium fluxes may have been lower in insulin dependent patients and in hypertensive patients. The most marked erythrocyte defects associated with hypertension were low erythrocyte water content and increased potassium concentration in non-insulin dependent diabetic patients. Treatment with captopril caused an increase in erythrocyte water and a decrease in ion content and concentration. In non-insulin dependent diabetic patients, who had the greatest increases in erythrocyte water and falls in potassium concentration, frusemide-sensitive sodium-potassium co-transport activity was reduced. The reduction in blood pressure with captopril treatment was related to the initial erythrocyte sodium content.
Thomas
T H
TH
Department of Medicine, University of Newcastle upon Tyne, UK.
Mbanya
J C
JC
Taylor
R
R
Alberti
K G
KG
Wilkinson
R
R
D001692:Biological Transport; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood; D004573:Electrolytes / Q000097:blood*; D004912:Erythrocytes / Q000032:analysis*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
D002216:Captopril; D004573:Electrolytes; D006442:Glycated Hemoglobin