[Do kinins have significance for the antihypertensive effect of angiotensin-converting enzyme inhibitors?].
Inhibition of angiotensin I converting enzyme (ACE, kininase II) results in a reduced release of angiotensin II and in an accumulation of kinins. By pretreatment with inhibitors of the kallikrein-kinin systems, the blood pressure lowering effect of the ACE-inhibitors will be diminished. These results suggest that potentiation of kinins will participate in the blood pressure reduction by ACE-inhibitors. However, other studies contradict this hypothesis, showing that the inhibition of kallikrein-kinin systems per se will often result in a reduction of stimulated renin activity. Even the measurement of kinins in the blood cannot clarify the role of kinins in ACE-inhibition. Some new investigations discuss only a local and tissue-specific enhancement of kinins after ACE-inhibition, but up to now strong evidence for participation of kinins by local mechanisms in the action of ACE-inhibitors is still missing.
Bönner
G
G
Medizinische Universitätsklinik II, Krankenhaus Merheim, Köln.
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007705:Kinins / Q000097:blood*; D012084:Renin-Angiotensin System / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors; D007705:Kinins
Haben die Kinine eine Bedeutung für die antihypertensive Wirkung der ACE-Hemmer?