title: Olsalazine in the treatment of mild to moderate ulcerative colitis: a randomized, placebo-controlled, double-blind, clinical trial.
abstract: Olsalazine, 2 g/day, was compared with placebo in 126 patients with mild or moderate ulcerative colitis. Evaluation after 4 weeks revealed a significant improvement in endoscopic findings in the rectum and sigmoid colon and in the clinical parameters rectal mucus and blood discharge, whereas no significant difference was found between olsalazine and placebo groups in clinical parameters, such as stool frequency and consistency, urge to defecate, abdominal pain and biopsy findings. It is concluded that olsalazine, 2 g/day, is tolerated as well as placebo except that it caused diarrhoea in some patients.
authors.affiliation: Stadtkrankenhaus Neuwied, West Germany.
authors.forename: G E
authors.initials: GE
authors.lastname: Feurle
authors.forename: D
authors.initials: D
authors.lastname: Theuer
authors.forename: S
authors.initials: S
authors.lastname: Velasco
authors.forename: B A
authors.initials: BA
authors.lastname: Barry
authors.forename: D
authors.initials: D
authors.lastname: Wördehoff
authors.forename: A
authors.initials: A
authors.lastname: Sommer
authors.forename: Y
authors.initials: Y
authors.lastname: Jantschegk
authors.forename: W
authors.initials: W
authors.lastname: Kruis
mesh_terms: D000636:Aminosalicylic Acids / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D003967:Diarrhea / Q000139:chemically induced; D004311:Double-Blind Method; D006801:Humans; D011897:Random Allocation
chemical_list: D000636:Aminosalicylic Acids; C032587:olsalazine