[Anti-angina effect of foridon in patients with stable exertion-induced stenocardia].
Twenty-three patients with coronary heart disease and stable angina of effort who took a single dose (30 mg) of ryodipine and nifedipine underwent exercise tests on a bicycle ergometer. Ten patients received ryodipine in two doses and placebo by a single-blind protocol. The single dise of ryodipine increased exercise time by 36% and intensity by 40%. Nifedipine produced the same action. When given in a dose of 150 mg/day for a short period of time, ryodipine reduced the frequency of anginal attacks by 39% and the number of nitroglycerin tablets used by 30%. The duration of physical exercise and its performance were increased by 53% and 63%, respectively. The effect was identical at 250 mg per day. The results proved ryodipine to be an effective antianginal agent.
Glukhovtsev
E V
EV
Kocherga
E Iu
EIu
Gratsianskiĭ
N A
NA
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy* / Q000209:etiology; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005082:Physical Exertion; D010919:Placebos; D012107:Research Design; D014665:Vasodilator Agents
D010919:Placebos; D014665:Vasodilator Agents; D009543:Nifedipine; C045912:ryodipine
Antianginal'nyĭ effekt foridona u bol'nykh so stabil'noĭ stenokardieĭ napriazheniia.