Effect of lactation on insulin sensitivity of glucose metabolism in rat adipocytes.
During lactation glucose metabolism in paraovarian adipocytes is characterized by a 40 and 80% decrease of glucose incorporation into CO2 and fatty acids in the presence of insulin. In contrast with the stimulation by insulin of glucose incorporation into lactate, glycerol remains unchanged. As a result, insulin sensitivity of total glucose metabolism (oxidation and lipid synthesis) is not altered in adipocytes from lactating rats.
Burnol
A F
AF
Guerre-Millo
M
M
Lavau
M
M
Girard
J
J
D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D007773:Lactates / Q000096:biosynthesis; D007774:Lactation / Q000187:drug effects; D019344:Lactic Acid; D050356:Lipid Metabolism; D010053:Ovary; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D007773:Lactates; D002245:Carbon Dioxide; D019344:Lactic Acid; D005947:Glucose