[Amino acid substitutions in the beta-subunit of RNA-polymerase from E. coli compensating for mutation-induced damage of the rho termination factors].
Ts-phenotype of the E. coli rho-factor mutant rho 15 is suppressed by two rifampicin-resistance mutations, rhoB1019 resulting in a single amino acid substitution Val146----Phe and rhoB268 resulting in a single substitution Gln513----Leu in beta-subunit of the E. coli RNA polymerase. Rifampicin-resistance mutations rhoB255 (Asp516----Val), rhoB1016 (Asp516----Asn), rhoB1001 (His526----Tyr), rhoB1004 (Ser531----Phe), rhoB1005 (Pro564----Leu), and streptolydigin-resistance' mutation rhoB1018 (double substitution Gly544----Asp and Phe545----Ser) do not suppress the rho15 mutation.
Ogryz'ko
E P
EP
Nikiforov
V G
VG
Borodin
A M
AM
Danilkovich
A V
AV
Monastyrskaia
G S
GS
D012321:DNA-Directed RNA Polymerases / Q000235:genetics*; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics; D009154:Mutation; D010454:Peptide Termination Factors / Q000235:genetics*; D010641:Phenotype; D012234:Rho Factor / Q000235:genetics*; D012293:Rifampin / Q000494:pharmacology; D014157:Transcription Factors / Q000235:genetics*
D010454:Peptide Termination Factors; D012234:Rho Factor; D014157:Transcription Factors; D012321:DNA-Directed RNA Polymerases; D012293:Rifampin
Aminokislotnye zameny v beta-sub''edinitse RNK-polimerazy E. coli, kompensiruiushchie mutatsionnye povrezhdeniia faktora terminatsii ro.