title: Alterations of the hypothalamic GnRH interpulse interval sequence over the normal menstrual cycle.
abstract: Luteinizing hormone (LH) is released in a pulsatile fashion from the anterior pituitary in response to hypothalamic gonadotropin-releasing hormone (GnRH) secretion. Previous autocorrelation analysis of the sequence of interpulse intervals of LH secretion in normal men has supported the hypothesis that the underlying hypothalamic mechanism of GnRH secretion governing episodic LH release is a renewal process, indicating that hypothalamic "memory," if present, does not extend back further in time than the preceding secretory pulse. A similar analysis of pulsatile LH secretion was undertaken in 45 studies of normal women, obtained throughout the menstrual cycle. Analysis of these studies revealed a process consistent with renewal throughout the follicular and early luteal phases. However, this relationship appears to break down in the mid-to-late luteal phase, indicating that alternative feedback pathways provide an overriding influence on the underlying renewal process of hypothalamic GnRH secretion. Pulsatile progesterone secretion by the corpus luteum, which first emerges at this stage of the menstrual cycle, may be the agent responsible for this feedback.
authors.affiliation: Department of Medicine, Massachusetts General Hospital, Boston 02114.
authors.forename: N
authors.initials: N
authors.lastname: Santoro
authors.forename: J P
authors.initials: JP
authors.lastname: Butler
authors.forename: M
authors.initials: M
authors.lastname: Filicori
authors.forename: W F
authors.initials: WF
authors.lastname: Crowley
mesh_terms: D005260:Female; D005498:Follicular Phase; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism*; D008183:Luteal Phase; D007986:Luteinizing Hormone / Q000378:metabolism; D008597:Menstrual Cycle; D010507:Periodicity; D010906:Pituitary Hormone-Releasing Hormones / Q000378:metabolism*; D012016:Reference Values
chemical_list: D010906:Pituitary Hormone-Releasing Hormones; D007986:Luteinizing Hormone