title: [Structure-activity relationships applied to quinoxaline-1,4-dioxides].
abstract: Studies on structure-activity relationships applied to quinoxaline 1,4-dioxides were performed on the basis of Hansch analysis. It could be demonstrated that correlations exist between MIC values (Escherichia coli) and physicochemical parameters. On the other hand, correlations were also found between nutritive effects determined on chicken and structural parameters. The results obtained could be confirmed by means of Free-Wilson analysis.
authors.affiliation: Zentralinstitut für Organische Chemie, Akademie der Wissenschaften der DDR.
authors.forename: D
authors.initials: D
authors.lastname: Schönfelder
authors.forename: G
authors.initials: G
authors.lastname: Stumm
authors.forename: M
authors.initials: M
authors.lastname: Bohle
authors.forename: H J
authors.initials: HJ
authors.lastname: Niclas
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003497:Cyclic N-Oxides / Q000138:chemical synthesis / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D011810:Quinoxalines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013816:Thermodynamics
chemical_list: D000900:Anti-Bacterial Agents; D003497:Cyclic N-Oxides; D011810:Quinoxalines
vernacular_title: Struktur-Wirkungs-Beziehungen bei Chinoxalin-1,4-dioxiden.