title: A clinical trial to assess the efficacy of sanguinarine-zinc mouthrinse (Veadent) compared with chlorhexidine mouthrinse (Corsodyl).
abstract: A single-blind crossover study was used to compare the ability of a 0.2% chlorhexidine mouthrinse (Corsodyl) with a sanguinarine-zinc mouthrinse (Veadent) to inhibit plaque and gingivitis. 14 volunteers starting with plaque-free mouths and optimal gingival health, rinsed with the preparations over two 19-day periods whilst refraining from all other oral hygiene procedures. At days 8, 15 and 19 of the trial, Corsodyl was significantly more effective at inhibiting both plaque and gingivitis. The findings of this study would suggest that the Veadent mouthrinse would at most only have a limited rôle as an inhibitor of plaque and gingivitis.
authors.affiliation: Department of Periodontology, College of Medicine, Heath Park, Cardiff, South Wales, UK.
authors.forename: J
authors.initials: J
authors.lastname: Moran
authors.forename: M
authors.initials: M
authors.lastname: Addy
authors.forename: R
authors.initials: R
authors.lastname: Newcombe
mesh_terms: D000328:Adult; D000470:Alkaloids / Q000008:administration & dosage*; D053119:Benzophenanthridines; D002710:Chlorhexidine / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003773:Dental Plaque / Q000517:prevention & control*; D005260:Female; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D007546:Isoquinolines; D008297:Male; D009067:Mouthwashes / Q000627:therapeutic use*; D011897:Random Allocation; D015032:Zinc / Q000008:administration & dosage*
chemical_list: D000470:Alkaloids; D053119:Benzophenanthridines; D007546:Isoquinolines; D009067:Mouthwashes; C005705:sanguinarine; D015032:Zinc; D002710:Chlorhexidine