title: Detection of alpha-transducin in retinal rods but not cones.
abstract: The distribution in chicken retina of the alpha subunit of transducin, the guanine nucleotide--binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3',5'-monophosphate phosphodiesterase, was determined with the aid of a specific antiserum. alpha-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to alpha-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.
authors.forename: G B
authors.initials: GB
authors.lastname: Grunwald
authors.forename: P
authors.initials: P
authors.lastname: Gierschik
authors.forename: M
authors.initials: M
authors.lastname: Nirenberg
authors.forename: A
authors.initials: A
authors.lastname: Spiegel
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D002417:Cattle; D002645:Chickens; D005455:Fluorescent Antibody Technique; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008253:Macaca mulatta; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000276:immunology / Q000378:metabolism*; D010786:Photoreceptor Cells / Q000378:metabolism*; D012160:Retina / Q000254:growth & development / Q000378:metabolism; D014018:Tissue Distribution; D015293:Transducin
chemical_list: D046911:Macromolecular Substances; D008565:Membrane Proteins; D019204:GTP-Binding Proteins; D015293:Transducin