Preventive effect of captopril on the development of experimental hypertension in rats.
The arterial blood pressure (BP), the ratio between gram myocardial mass per 100 g body mass (R), the plasma renin activity (PRA) and the aldosteron content in the blood plasma (PA) were investigated in a model of renal hypertension, 30 days after the operation, in the following groups of male Wistar rats: operated and treated throughout the entire experimental period with captopril Pharmachim in a dose of 30 mg/kg body mass twice daily orally, and two control groups--operated and treated with saline, and non-operated animals of the same age, treated only with saline. BP, R and PA increase significantly in the control group with experimental hypertension. In the group treated with captopril PRA was more than doubled compared with the two control groups, with a considerable decrease in PA compared with the control group with hypertension. The results obtained for the captopril-treated experimental group (with the exception of PRA) are identical and close to the data for the control non-operated animals, i.e. the treatment of the experimental animals with captopril prevents the development of arterial hypertension and of myocardial hypertrophy with the coarctation hypertension model used.
Petkov
O
O
Research Chemical-Pharmaceutical Institute, Medical Academy, Sofia.
Mihailova-Todorova
S
S
Kolarova
R
R
Ankov
V
V
D000450:Aldosterone / Q000097:blood; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use*; D006978:Hypertension, Renovascular / Q000517:prevention & control*; D007668:Kidney / Q000473:pathology; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood
D000450:Aldosterone; D002216:Captopril; D012083:Renin