[Acute injury to the gastric mucosa by acetylsalicylic acid. A comparative endoscopic study in man with oral prostaglandin analogs, omeprazole and ranitidine].
The deleterious effects of acetylsalicylic acid (ASA) on gastric mucosa have been well documented in experimental and clinical studies. With a direct endoscopic assay system we evaluated in healthy volunteers whether pretreatment with prostaglandin analogues (misoprostol, rioprostil), omeprazole and ranitidine prevented ASA-induced gastric mucosal injuries. Ranitidine (2 X 150 mg/d) in large antisecretory doses almost completely abolished these changes (p less than 0.05). By contrast, misoprostol (4 X 50 micrograms/d and 4 X 200 micrograms/d), rioprostil (3 X 100 micrograms/d), omeprazole (5 mg and 10 mg/d) as well as ranitidine in non-antisecretory doses (2 X 25 mg/d) did not reduce gastric mucosal injury after single-dose ASA administration. The results of this trial indicate that socalled cytoprotective doses of prostaglandins, omeprazole and ranitidine in contrast to animal findings are not effective in preventing acute ASA-induced mucosal damage.
Müller
P
P
Dammann
H G
HG
Simon
B
B
D000328:Adult; D000527:Alprostadil / Q000031:analogs & derivatives / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001241:Aspirin / Q000009:adverse effects*; D001562:Benzimidazoles / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D016595:Misoprostol; D009853:Omeprazole; D011458:Prostaglandins E / Q000494:pharmacology; D011465:Prostaglandins, Synthetic / Q000494:pharmacology*; D011897:Random Allocation; D011899:Ranitidine / Q000494:pharmacology*; D016630:Rioprostil; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control
D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D011458:Prostaglandins E; D011465:Prostaglandins, Synthetic; D016595:Misoprostol; D016630:Rioprostil; D011899:Ranitidine; D000527:Alprostadil; D009853:Omeprazole; D001241:Aspirin
Akute Schädigung der Magenschleimhaut durch Acetylsalicylsäure. Eine endoskopische Vergleichsstudie am Menschen mit oral wirksamen Prostaglandin-Analoga, Omeprazol und Ranitidin.