Cardiovascular changes in dogs given diazepam and diazepam-ketamine.
The cardiopulmonary consequences of diazepam (0.5 mg/kg, IV) followed by ketamine (10 mg/kg, IV) were evaluated in 11 dogs. Diazepam did not exhibit a tranquilizing effect and was frequently associated with excessive excitement. It produced minimal cardiopulmonary effects, except for a significant increase in heart rate. Ketamine administration was associated with less cardiovascular stimulation when administered after diazepam than it did when administered alone; the respiratory depression was greater. Compared with ketamine alone, the diazepam-ketamine combination was associated with more vomition, less muscle hypertonus, less seizure activity, and less salivation.
Haskins
S C
SC
Farver
T B
TB
Patz
J D
JD
D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output / Q000187:drug effects; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology*; D004285:Dogs; D004347:Drug Interactions; D004562:Electrocardiography; D006863:Hydrogen-Ion Concentration; D007649:Ketamine / Q000494:pharmacology*; D008170:Lung Compliance / Q000187:drug effects; D010100:Oxygen / Q000097:blood; D012119:Respiration / Q000187:drug effects; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D002245:Carbon Dioxide; D007649:Ketamine; D003975:Diazepam; D010100:Oxygen