[In vitro activity of roxithromycin compared to 5 other macrolides against staphylococci].
This study aimed to compare the bacteriostatic activity of roxithromycin (RU) to those of erythromycin (ERY), troleandomycin (TAO), spiramycin (SPI), josamycin (JOS) and midekamycin (MID) against staphylococci strains. 239 strains of hospital origin were analysed: S. aureus (139), coagulase negative staphylococci (CNS) (100). The MIC were determined by the agar dilution method. The modal MIC, the MIC 50 and 90 observed for the both groups of strains are given according to species and antibiotics. This study gives the opportunity to classify the 6 antibiotics in a decreasing order considering their antistaphylococcal activity: RU = ERY, TAO = SPI, JOS = MID. No difference was noticeable between S. aureus and CNS strains.
Brun
Y
Y
Centre National de Référence des Staphylocoques, Faculté de Médecine Alexis-Carrel, Lyon.
Coulet
M
M
Forey
F
F
Fleurette
J
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003030:Coagulase / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007933:Leucomycins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000188:drug therapy; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003030:Coagulase; D007933:Leucomycins
Activité in vitro de la roxithromycine comparée à celle de cinq autres macrolides sur les staphylocoques.