title: Chlorambucil overdose: accidental ingestion of an antineoplastic drug.
abstract: A 22-month-old, 10 kg child ingested 32 mg of chlorambucil and developed irritability, myoclonic-like muscle jerks, an exaggerated startle reflex, vomiting, and EEG changes within a few hours. The neurologic symptoms improved overnight, and the patient was discharged at about 28 hours postingestion. During the three weeks of follow-up, mild bone marrow suppression occurred and resolved. A normal EEG was reported at 33 weeks postingestion.
authors.affiliation: Rocky Mountain Poison & Drug Center, Denver, Colorado 80204.
authors.forename: S A
authors.initials: SA
authors.lastname: Vandenberg
authors.forename: K
authors.initials: K
authors.lastname: Kulig
authors.forename: D G
authors.initials: DG
authors.lastname: Spoerke
authors.forename: A H
authors.initials: AH
authors.lastname: Hall
authors.forename: V J
authors.initials: VJ
authors.lastname: Bailie
authors.forename: B H
authors.initials: BH
authors.lastname: Rumack
mesh_terms: D000061:Accidents, Home; D002606:Charcoal / Q000627:therapeutic use; D002699:Chlorambucil / Q000506:poisoning*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D008278:Magnesium Sulfate / Q000627:therapeutic use; D012640:Seizures / Q000139:chemically induced
chemical_list: D002606:Charcoal; D002699:Chlorambucil; D008278:Magnesium Sulfate