Echinococcus multilocularis: in vivo results of therapy with albendazole and praziquantel.
The effects of albendazole and praziquantel on the growth of Echinococcus multilocularis were studied in cotton rats. Albendazole (20 and 50 mg/kg) reduced parasite weight and increased the length of survival of infected animals but viable infection was present after treatment. In an in vitro system albendazole sulphoxide entered cysts of E. multilocularis passively. Praziquantel 100 mg/kg was ineffective but 500 mg/kg significantly inhibited growth. A combination of albendazole and praziquantel was no more effective than either agent alone.
Taylor
D H
DH
Department of Surgery, University Hospital, Nottingham, UK.
Morris
D L
DL
Richards
K S
KS
Reffin
D
D
D015766:Albendazole; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D003411:Arvicolinae; D001562:Benzimidazoles / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D004443:Echinococcosis / Q000188:drug therapy*; D004446:Echinococcus / Q000187:drug effects; D011223:Praziquantel / Q000627:therapeutic use*; D013997:Time Factors
D000871:Anthelmintics; D001562:Benzimidazoles; D011223:Praziquantel; D015766:Albendazole