[Placental growth hormone. Significance relative to growth hormone and lactogen hormone].
Normal human placenta secretes within maternal compartment a pregnancy associated protein, placental growth hormone (PGH). This entity, agonist of pituitary GH, appears responsible for the elevated IGF I blood levels observed in the mother during pregnancy, while pituitary GH is no longer secreted. PGH could thus play a significant role in the anabolic processes of pregnancy. The biochemical mechanism responsible for PGH production is the expression of the GH-V gene at the placental level. This has been demonstrated by the positive probing of GH-V mRNA in this tissue, by the establishment of the restriction map and sequence of its cDNA as well as by the NH2-terminal sequence determination of both 22 and 25K PGH forms. The positive aspect of this function for human reproduction gains weight in that a placenta deleted for the CS-A, GH-V and CS-B gene expresses alternative genes coding for protein similar or related to pituitary GH or hPL, respectively.
Hennen
G
G
Endocrinologie expérimentale et clinique, Institut de Pathologie, Liège, Belgique.
Frankenne
F
F
Scippo
M L
ML
Igout
A
A
Closset
J
J
Pirens
G
G
Gomez
F
F
D000595:Amino Acid Sequence; D005260:Female; D005786:Gene Expression Regulation; D013006:Growth Hormone / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D010920:Placenta / Q000378:metabolism; D010928:Placental Lactogen / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D011247:Pregnancy
D013006:Growth Hormone; D010928:Placental Lactogen
Hormone de croissance placentaire. Signification par rapport aux hormones de croissance et lactogène.