title: Intralipid disappearance in critically ill patients.
abstract: Intralipid elimination patterns were compared in 25 healthy controls, 12 patients recovering from uncomplicated cholecystectomy, and 25 critically ill patients. The intravenous fat tolerance test revealed a similar fractional removal rate (k2) in healthy controls and critically ill patients, but k2 was increased in cholecystectomy patients. The concentration of cross-reactive protein (CRP) correlated positively to the concentration of total triglyceride and low-density lipoprotein-triglyceride, and negatively to low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol. The extrapolated zero-time concentration of Intralipid in the critically ill patients was only one-third of the value in healthy controls. After this initial loss, however, Intralipid was removed from the circulation after first-order kinetics. These low concentrations of Intralipid were not correlated with concentrations of CRP. Possible explanations for this phenomenon include a change in the configuration of the lipid particles, the so-called creaming phenomenon, and/or immediate and substantial uptake of the emulsion by certain organs.
authors.forename: A
authors.initials: A
authors.lastname: Lindh
authors.forename: M
authors.initials: M
authors.lastname: Lindholm
authors.forename: S
authors.initials: S
authors.lastname: Rössner
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000097:blood; D002763:Cholecystectomy; D002784:Cholesterol / Q000097:blood; D003422:Critical Care; D005217:Fat Emulsions, Intravenous / Q000097:blood / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000627:therapeutic use; D006242:Haptoglobins / Q000097:blood; D006801:Humans; D007700:Kinetics; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000628:therapy; D009961:Orosomucoid / Q000097:blood; D010289:Parenteral Nutrition, Total; D011184:Postoperative Period; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D005217:Fat Emulsions, Intravenous; D006242:Haptoglobins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D009961:Orosomucoid; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol; D005947:Glucose