Development of spindle-shaped cells and chondroid cells from androgen-dependent Shionogi carcinoma 115. A light and electron microscopic study.
Androgen-dependent Shionogi carcinoma 115 (SC115) is an undifferentiated medullary carcinoma consisting of compact round cells. However, when host male DS mice were castrated 2 weeks after tumor transplantation, tumors composed of compact round cells, spindle-shaped cells and chondroid cells grew 4 weeks after castration. Compact round cells with desmosomes were arranged in solid nests and exhibited immunoreactivity for keratin protein. Spindle-shaped cells had prominent rough endoplasmic reticulum, and appeared to secrete collagen. Chondroid cells had the characteristics of chondrocytes. The light and electron microscopic features were highly suggestive of a transition from compact round cells to spindle-shaped cells, and from spindle-shaped cells to chondroid cells. The histology of this tumor thus suggests that SC115 cells are able to change into chondroid cells via spindle-shaped cells.
Terada
N
N
Department of Pathology, Center for Adult Diseases, Osaka, Japan.
Yamamoto
R
R
Uchida
N
N
Mori
H
H
Takada
T
T
Taniguchi
H
H
Tsuji
M
M
Kitamura
Y
Y
Matsumoto
K
K
D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D002356:Cartilage / Q000473:pathology*; D003094:Collagen / Q000032:analysis; D006651:Histocytochemistry; D007124:Immunoenzyme Techniques; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D009919:Orchiectomy; D011509:Proteoglycans / Q000032:analysis
D000728:Androgens; D011509:Proteoglycans; D003094:Collagen