title: Monoclonal gammopathy with an insulin binding IgG(K) M-component, associated with severe hypoglycaemia.
abstract: A case is described in which a monoclonal gammopathy was associated with postprandial hypoglycaemia, resulting from insulin binding by the M-component. The monoclonal immunoglobulin possessed a low affinity for insulin, but its binding capacity was very high. Cytotoxic chemotherapy and diazoxide treatment failed to prevent severe hypoglycaemic attacks.
authors.forename: W J
authors.initials: WJ
authors.lastname: Sluiter
authors.forename: J
authors.initials: J
authors.lastname: Marrink
authors.forename: B
authors.initials: B
authors.lastname: Houwen
mesh_terms: D000911:Antibodies, Monoclonal / Q000032:analysis*; D004587:Electrophoresis, Agar Gel; D005951:Glucose Tolerance Test; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology* / Q000517:prevention & control; D007122:Immunoelectrophoresis; D007074:Immunoglobulin G / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D007328:Insulin