Chemical radioprotection to bone marrow stem cells after whole body gamma irradiation to mice.
Protection to mice bone marrow stem cells has been noted as early as two days after whole body gamma ray exposure by prior treatment with combination of hydroxytryptophan (HT) and one of the two thiol drugs viz., aminoethylisothiuronium bromide hydrobromide (AET) (20 mg/kg body weight) and B-mercaptopropionylglycine (MPG). The levels of protection to bone marrow stem cells thus obtained have been compared to that obtained by treating with the optimum radioprotecting dose of AET (200 mg/kg body weight). The study reports the bone marrow stem cells status after two days of 3 Gy, 5 Gy and 10 Gy whole body gamma irradiation in relation to the mentioned radioprotecting treatments as studied by spleen colony forming method.
Dey
J
J
Institute of Nuclear Medicine and Allied Sciences, Delhi, India.
Dey
T B
TB
Ganguly
S K
SK
Nagpal
K K
KK
Ghose
A
A
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects*; D003114:Colony-Forming Units Assay; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013234:Stem Cells / Q000187:drug effects / Q000528:radiation effects*; D008625:Tiopronin / Q000494:pharmacology*; D014916:Whole-Body Irradiation; D000338:beta-Aminoethyl Isothiourea / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D006916:5-Hydroxytryptophan; D008625:Tiopronin