title: Importance of beta-lactamases and clinical implications of their inhibitors.
abstract: The production of beta-lactamases has constituted the main line of defence of bacteria exposed to beta-lactam antibiotics. beta-Lactamases may be part of the natural constitution of the cell, acquired by DNA transferred from other bacteria or induced by exposure to a beta-lactam antibiotic. Many different types of beta-lactamases have been described in a variety of bacteria.
authors.affiliation: Department of Medical Microbiology, London Hospital Medical College.
authors.forename: J D
authors.initials: JD
authors.lastname: Williams
mesh_terms: D004352:Drug Resistance, Microbial; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases