Survival of bacteriophage 1 of the Salmonella typhimurium phage typing scheme in different liquid pharmaceutical preparations.
The survival of bacteriophage 1 of the Salmonella typhimurium phage typing scheme was studied in seven commonly used liquid pharmaceutical preparations of different composition. Commercially available flacons of Septobore colyre, Thilodexine eye drops, Bradoral gargle solution, Novalgin drops, Garamycin injection, Anatoxal-antigen tetanic purificate and Antidiphtheric serum, were used. It was found that the phage viability in these drugs varied greatly. Thus in Septobore the page was almost completely eliminated in less than one week, while in Garamycin the number of plaque forming units (PFU) remained stable during the experiment (18 months). The viability of the phage showed intermediate values in the other five pharmaceutical preparations. The possible reasons for these differences in viability and the significance of phage (and viruses) survival in medicins are discussed.
Papaconstantinou
A T
AT
Department of Microbiology, Faculty of Medicine, National University of Athens, Greece.
Leonardopoulos
J G
JG
Sacetou
H
H
Papavassiliou
J T
JT
D001434:Bacteriophage Typing; D001435:Bacteriophages / Q000302:isolation & purification*; D004203:Disinfection; D004340:Drug Contamination; D012486:Salmonella typhimurium; D013242:Sterilization; D013997:Time Factors