title: MR imaging of acute experimental ischemia in cats.
abstract: The evolution of acute cerebral ischemia was documented by magnetic resonance (MR) imaging in 13 mongrel cats with occlusion of the middle cerebral artery through a transorbital approach. The animals were imaged under anesthesia at intervals from 30 min to 10 days after production of the lesion. An MR imager operating at 0.35 T was used with multislice, multi-spin-echo technique (TR = 500-2000 msec; TE = 28, 56 msec). The animals were sacrificed after imaging for pathologic correlation. Infarcts beyond 4 hr of age were visualized in all subjects. The earliest infarct was seen at 30 min (two cats) as an area of high signal intensity on T2-weighted images. In three other cats, however, 3-hr-old infarcts were not detectable. In one animal, a hemorrhage within a 1-week-old area of infarction was not characterized by MR imaging but was identified on CT scanning. The mass effect of the infarction appeared greatest at 2-4 days after infarction. The basal ganglia showed ischemic effects to best advantage. MR imaging offers previously unavailable sensitivity for the early noninvasive detection of cerebral ischemia in vivo.
authors.forename: M
authors.initials: M
authors.lastname: Brant-Zawadzki
authors.forename: B
authors.initials: B
authors.lastname: Pereira
authors.forename: P
authors.initials: P
authors.lastname: Weinstein
authors.forename: S
authors.initials: S
authors.lastname: Moore
authors.forename: W
authors.initials: W
authors.lastname: Kucharczyk
authors.forename: I
authors.initials: I
authors.lastname: Berry
authors.forename: M
authors.initials: M
authors.lastname: McNamara
authors.forename: N
authors.initials: N
authors.lastname: Derugin
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D002415:Cats; D002543:Cerebral Hemorrhage / Q000473:pathology; D002544:Cerebral Infarction / Q000473:pathology; D005069:Evaluation Studies as Topic; D002546:Ischemic Attack, Transient / Q000175:diagnosis* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D013997:Time Factors