title: [Interaction between various alkylxanthines and the proteins of the erythrocyte skeleton].
abstract: We searched an interaction between (i) pentoxifylline and/or propentofylline, and (ii) the red cell membrane with special emphasis on the membrane skeleton. It appeared (i) that propentofylline has no permanent binding site on the membrane, (ii) that propentofylline and/or pentoxifylline do not detectably alter spectrin conformation (no change of spectrin dimer self-association or of spectrin limited digestion in the presence of trypsin), and (iii) that these compounds have no effect on membrane protein phosphorylation, particularly the cAMP-dependent and TPA-dependent phosphorylation of protein 4.1.
authors.affiliation: CNRS UA 1171, Faculté de Médecine Grange-Blanche, Lyon, France.
authors.forename: J
authors.initials: J
authors.lastname: Delaunay
authors.forename: B
authors.initials: B
authors.lastname: Pothier
authors.forename: F
authors.initials: F
authors.lastname: Baklouti
authors.forename: L
authors.initials: L
authors.lastname: Morlé
mesh_terms: D003598:Cytoskeletal Proteins / Q000378:metabolism; D004347:Drug Interactions; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D010431:Pentoxifylline / Q000494:pharmacology*; D010766:Phosphorylation; D013049:Spectrin / Q000378:metabolism; D013805:Theobromine / Q000031:analogs & derivatives*; D014970:Xanthines / Q000494:pharmacology*
chemical_list: D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D014970:Xanthines; D013049:Spectrin; C032114:propentofylline; D013805:Theobromine; D010431:Pentoxifylline
vernacular_title: Recherche d'une interaction entre certaines alkylxanthines et les protéines du squelette érythrocytaire.