[Monooxygenase system activity and rate of lipid peroxidation in rat liver microsomes in reinduction with polychlorinated biphenyls].
Single oral administration of sovol (mixture of polychlorinated diphenyls) caused a significant induction of the liver monooxygenase system (MOS) in rats. The inducing effect persisted for 5 months. Liver MOS responses were similar in repeated and primary sovol administrations. Differences in the morphological liver changes have been detected following single and repeated administrations of sovol.
Tutel'ian
V A
VA
Khan
A V
AV
Lashneva
N V
NV
Sorokovaia
G K
GK
Gadzhieva
Z M
ZM
D000633:Aminopyrine N-Demethylase / Q000096:biosynthesis; D000815:Aniline Hydroxylase / Q000096:biosynthesis; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D003573:Cytochrome b Group / Q000096:biosynthesis; D015786:Cytochromes b5; D004790:Enzyme Induction / Q000187:drug effects; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D011078:Polychlorinated Biphenyls / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D003573:Cytochrome b Group; D008054:Lipid Peroxides; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls; D006899:Mixed Function Oxygenases; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase
Aktivnost' monooksigenaznoĭ sistemy i skorost' perekisnogo okisleniia lipidov v mikrosomakh pecheni krys pri reinduktsii poliklorirovannymi difenilami.