Partial reversal of barbiturate anesthesia by dopamine antagonism: an electroencephalographic study.
The D-1 dopamine antagonist, SCH 23390, was administered to rats under barbiturate anesthesia. Recording of the power frequency spectrum of the electroencephalogram (EEG) showed that the D-1 antagonist shifted the relative power in the EEG to higher frequencies. In contrast, a relatively selective D-2 antagonist, haloperidol, administered under the same conditions, had no effect. These results suggest that SCH 23390 can partially reverse barbiturate anesthesia, and imply that central dopamine, acting at the D-1 site, might modulate this type of anesthetic.
Sinton
C M
CM
Research Department, CIBA-GEIGY Corporation, Summit, NJ 07901.
Goeller
C J
CJ
D000758:Anesthesia; D000818:Animals; D001463:Barbiturates / Q000008:administration & dosage*; D001552:Benzazepines / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism* / Q000502:physiology; D004569:Electroencephalography; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001463:Barbiturates; D001552:Benzazepines; D006220:Haloperidol; D004298:Dopamine