title: Contributions to reproductive medicine through in-vitro fertilization: a review.
abstract: In vitro fertilization (IVF) is now an accepted treatment procedure for subfertility. Its use has also contributed greatly to the understanding of our knowledge in reproductive medicine. This review looks at these contributions. In the female, IVF has made it possible to examine more closely ovarian physiology through the follicular micro-environment, follicular dominance and cohorts. In the male, the new sperm preparation technology has assisted the investigation of sperm parameters in-depth. A better understanding of human egg and sperm physiology, the fertilization process and pre-implantation phenomena has also contributed to better management of the infertile couple. Perhaps in the future, the pre-implantation embryo may be considered as a "patient".
authors.affiliation: Department of Obstetrics & Gynaecology, National University of Singapore.
authors.forename: S C
authors.initials: SC
authors.lastname: Ng
authors.forename: S S
authors.initials: SS
authors.lastname: Ratnam
authors.forename: A
authors.initials: A
authors.lastname: Bongso
authors.forename: H H
authors.initials: HH
authors.lastname: Goh
authors.forename: P C
authors.initials: PC
authors.lastname: Wong
authors.forename: L K
authors.initials: LK
authors.lastname: Chan
authors.forename: L
authors.initials: L
authors.lastname: Hagglund
authors.forename: M P
authors.initials: MP
authors.lastname: Hamilton
mesh_terms: D005307:Fertilization in Vitro; D006801:Humans; D012098:Reproduction