Morphologic classification and incidence of hematopoietic neoplasms in the Sprague-Dawley rat.
Hematopoietic and related neoplasms were morphologically studied in a total of 1,765 male and 1,765 female Sprague-Dawley rats from 6 chronic toxicity studies conducted at a large toxicology testing laboratory. The most common types of lymphoid neoplasms seen included the lymphoblastic lymphoma (0.65%) and the large granular lymphocyte lymphoma (LGL, Fischer or mononuclear cell leukemia) (0.60%). The most common type of nonlymphoid neoplasm with morphologic features similar to lymphoid tumors was histiocytic sarcoma (1.1%). A small number of cases of myelogenous leukemia were also seen. Additional work is needed in the classification of hematopoietic neoplasms in rats including refined immunomorphological studies.
Frith
C H
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Toxicology Pathology Associates, Little Rock, Arkansas 72211.
D000818:Animals; D005260:Female; D007951:Leukemia, Myeloid / Q000145:classification / Q000453:epidemiology / Q000473:pathology; D008223:Lymphoma / Q000145:classification / Q000453:epidemiology / Q000473:pathology*; D008224:Lymphoma, Follicular / Q000145:classification / Q000453:epidemiology / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000145:classification / Q000453:epidemiology / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000453:epidemiology / Q000473:pathology; D008297:Male; D009374:Neoplasms, Experimental / Q000145:classification / Q000453:epidemiology / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains