[Development of multiple precancerous conditions and malignant skin tumors in immunosuppressive therapy].
A 45-year-old patient developed squamous cell carcinoma 4 years after renal transplantation and immunosuppressive therapy with azathioprine and fluocortolone. During the following 3 years, the patient developed on sun-exposed skin several premalignant hyperkeratoses, Bowen's carcinoma, basal cell carcinoma, as well as squamous cell carcinoma and carcinoma of the eccrine sweat glands, both showing the clinical picture of keratoacanthoma.
Krickeberg
H
H
Universitäts-Hautklinik Köln.
D001379:Azathioprine / Q000009:adverse effects; D005448:Fluocortolone / Q000009:adverse effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced* / Q000473:pathology; D011183:Postoperative Complications / Q000473:pathology; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology
D007166:Immunosuppressive Agents; D005448:Fluocortolone; D001379:Azathioprine
Entwicklung multipler Präkanzerosen und maligner Hauttumoren unter immunsuppressiver Therapie.