An integrated microcomputer system using immobilized cellular electrodes for drug screening.
Biosensors based on immobilized microbial cells were developed for drug screening in our laboratory. Compared with the conventional methods such as diffusion and dilution tests, biosensors have been demonstrated to be superior in sensitivity and require much shorter screening time. An integrated microcomputer system has been developed for data acquisition, database management, and mode of action estimation, which automates the screening processes and reduces the labor requirements significantly.
Li
X M
XM
Department of Chemical Engineering, University of Michigan.
Schwartz
R M
RM
Cesar
E Y
EY
Wang
H Y
HY
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015374:Biosensing Techniques; D004867:Equipment Design; D004926:Escherichia coli / Q000187:drug effects; D005103:Expert Systems; D008826:Microbial Sensitivity Tests / Q000295:instrumentation; D008838:Microcomputers; D012984:Software; D012985:Software Design; D015003:Yeasts / Q000187:drug effects
D000900:Anti-Bacterial Agents