title: The effects of triclabendazole on the lung fluke, Paragonimus uterobilateralis in the experimental host Sigmodon hispidus.
abstract: The new veterinary drug triclabendazole (Fasinex) was tested for its anthelmintic activity against adult Paragonimus uterobilateralis in experimentally infected cotton rats, Sigmodon hispidus. After a single dose of 50, 100 or 150 mg/kg b.w. triclabendazole or after two doses of 5 or 10 mg/kg b.w. given at an interval of 24 hours, 56-61% of the flukes were dead at three to five weeks after treatment. Two doses of 50 or 75 mg/kg b.w. triclabendazole killed all flukes. The flukes, which were still alive three to five weeks after treatment, were significantly smaller than the un-treated controls. Histological sections from these flukes showed severely damaged tissues. It is assumed that these flukes would have died later.
authors.affiliation: Department of Helminthology, Bernhard Nocht Institut for Tropical Medicine, Hamburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Weber
authors.forename: G
authors.initials: G
authors.lastname: Büscher
authors.forename: D W
authors.initials: DW
authors.lastname: Büttner
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use*; D003411:Arvicolinae; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D008297:Male; D010237:Paragonimiasis / Q000188:drug therapy* / Q000469:parasitology; D010238:Paragonimus / Q000033:anatomy & histology / Q000187:drug effects*; D000077682:Triclabendazole
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole