title: Cytoprotective effect of free radical scavengers against mucosal damage produced by different antirheumatic drugs.
abstract: Following 200 mg aspirin, 20 mg indomethacin or 100 mg diclofenac, gastric mucosal damage was evoked after five hours in rats. By administering vitamin A, vitamin E, MTDQ (6,6-methylenebis-2,2,4-trimethyl-1,2-dihydroquinoline), vitamin C, lipoic acid and penicillamine intragastrically at the time of the application of the damaging agent, the authors studied the beneficial effect of these free-radical scavengers upon the mucosal lesions. Vitamin C and penicillamine exerted no significant protective effect. Among the other drugs, the most effective were the lipid-soluble ones: vitamin A, vitamin E and MTDQ. The authors hypothesized that the gastric damage may be connected with the degradation of the polyunsaturated fatty acid components of the cellular membranes and thus the lipid-soluble free radical scavengers were able to offer protection.
authors.forename: T
authors.initials: T
authors.lastname: Jávor
authors.forename: F
authors.initials: F
authors.lastname: Tárnok
authors.forename: T
authors.initials: T
authors.lastname: Past
authors.forename: S
authors.initials: S
authors.lastname: Nagy
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000037:antagonists & inhibitors*; D000897:Anti-Ulcer Agents; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001241:Aspirin / Q000037:antagonists & inhibitors; D004008:Diclofenac / Q000037:antagonists & inhibitors; D005260:Female; D005609:Free Radicals; D005753:Gastric Mucosa / Q000187:drug effects*; D007213:Indomethacin / Q000037:antagonists & inhibitors; D008297:Male; D010396:Penicillamine / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D012995:Solubility; D008063:Thioctic Acid / Q000494:pharmacology; D014801:Vitamin A / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D000975:Antioxidants; D005609:Free Radicals; D011804:Quinolines; D014801:Vitamin A; D014810:Vitamin E; D004008:Diclofenac; C011923:6,6'-methylene bis(2,2,4-trimethyl-1,2-dihydroquinoline); D008063:Thioctic Acid; D010396:Penicillamine; D001205:Ascorbic Acid; D001241:Aspirin; D007213:Indomethacin