[Effects of radiotherapy on lymphocyte populations in lung cancer].
The authors report on the results of the immune monitoring of a study population of 31 patients with lung cancer who were treated with radiotherapy. A synthetic thymic pentapeptide, thymopentin, was employed whose effect was evaluated on the immunological parameters analyzed. After radiotherapy, a considerable and homogeneous decrement was observed in several lymphocytic subsets (less sensible in activated T-cells), together with a progressive decrement in the helper/suppressor ratio, in the long run. Monocytes and null cells showed more radioresistance. Thymopentin had no influence on the tested immunological parameters up to 6 months after radiotherapy; later on, a slightly more balanced helper/suppressor ratio could be noticed in the surviving patients who had been treated with thymopentin.
Gava
A
A
Istituto di Radioterapia Oncologica, Presidio Ospedaliero, Treviso.
Moro
L
L
De Angeli
S
S
Coghetto
F
F
Marazzato
G
G
Fantin
P
P
Patrese
P
P
D000230:Adenocarcinoma / Q000276:immunology / Q000532:radiotherapy*; D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000368:Aged; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects*; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000532:radiotherapy*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology / Q000532:radiotherapy*; D008215:Lymphocytes, Null / Q000276:immunology / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000627:therapeutic use; D011013:Pneumonectomy; D011867:Radioisotope Teletherapy; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects*; D016305:Thymopentin; D013946:Thymopoietins / Q000627:therapeutic use; D013997:Time Factors
D000276:Adjuvants, Immunologic; D003037:Cobalt Radioisotopes; D010446:Peptide Fragments; D013946:Thymopoietins; D016305:Thymopentin
Effetti della radioterapia sulle popolazioni linfocitarie nel cancro del polmone.