Langerhans cells in verruciform xanthomas: an immunoperoxidase study of 10 oral cases.
Ten oral verruciform xanthomas were studied using an immunoperoxidase stain for S-100 protein. All cases exhibited positively stained dendritic cells among the mononuclear inflammatory cell infiltrate at the base of the lesions and to a lesser extent among the "foam cells". The foam cells were, however, negative for S-100 staining. We suggest that, based on these findings, verruciform xanthomas belong to a new category of "non-X histiocytoses" in which the presence of Langerhans cells suggests an immunologic pathogenesis.
Rowden
D
D
Lovas
G
G
Shafer
W
W
Sheikh
K
K
D005487:Foam Cells / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007801:Langerhans Cells / Q000473:pathology*; D009059:Mouth Diseases / Q000473:pathology*; D009418:S100 Proteins; D014973:Xanthomatosis / Q000473:pathology*
D009418:S100 Proteins