Effects of vanadate and insulin on glucose 1,6-P2 and fructose 2,6-P2 levels in rat skeletal muscle.
Levels of glucose 1,6-P2 but not fructose 2,6-P2 were found decreased in skeletal muscle of alloxan-diabetic ketotic rats. Administration of both insulin and vanadate restored the altered values without affecting fructose 2,6-P2 concentrations. In normal rats, insulin increased muscle levels of both sugars, and vanadate decreased glucose 1,6-P2 without changing fructose 2,6-P2 levels. Enzymatic activities involved in glucose 1,6-P2 and fructose 2,6-P2 metabolism were not affected under any experimental condition.
Carreras
M
M
Unitat de Bioquimica, Facultat de Medicina, Universitat de Barcelona, Spain.
Bassols
A M
AM
Carreras
J
J
Climent
F
F
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D005635:Fructosediphosphates / Q000378:metabolism*; D019298:Glucose-6-Phosphate / Q000031:analogs & derivatives*; D005958:Glucosephosphates / Q000378:metabolism*; D006598:Hexosediphosphates / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014638:Vanadates / Q000494:pharmacology
D005635:Fructosediphosphates; D005958:Glucosephosphates; D006598:Hexosediphosphates; D007328:Insulin; D014638:Vanadates; D019298:Glucose-6-Phosphate; C027652:fructose 2,6-diphosphate; C016473:glucose-1,6-bisphosphate