[Organ-specific intestinal antigens contained in tumors of the human gastrointestinal tract].
Two organospecific antigens were found in extracts of human fetal intestinal mucosa. One of them is destroyed by boiling and its electrophoretic mobility corresponds to that of beta 1-globulins. On the contrary, the other antigen is thermostable and its electrophoretic mobility corresponds to alpha 2 globulins. Other properties of these antigens are similar. The comparison of the test systems to these antigens in double immunodiffusion showed that they reacted with each other making a "spure", but these antigens immunologically differ from CEA. Both of organospecific antigens were determined in all extracts of nonmalignant specimens of definite intestinal and colon mucosa and in most extracts of colon tumours. These antigens are usually absent in extracts of other normal and tumour tissues. These antigens are suggested to be of use as tumour markers in immunodiagnosis, immunoclassification and immunolocalization of gastrointestinal cancer.
Pugachev
K K
KK
Vasil'ev
M Iu
MIu
Avdeev
G I
GI
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis* / Q000276:immunology; D002850:Chromatography, Gel; D004355:Drug Stability; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis*; D006358:Hot Temperature; D006801:Humans; D007106:Immune Sera / Q000302:isolation & purification; D007114:Immunization; D005779:Immunodiffusion; D007123:Immunoelectrophoresis, Two-Dimensional; D007422:Intestines / Q000276:immunology*; D009928:Organ Specificity; D011817:Rabbits
D000951:Antigens, Neoplasm; D007106:Immune Sera
Organospetsificheskie kishechnye antigeny, soderzhashchiesia v opukholiakh zheludochno-kishechnogo trakta cheloveka.