title: Immunohistochemical localization of glutathione peroxidase in ocular tissue.
abstract: In this study enzyme glutathione peroxidase was localized in ocular tissue of Lewis rats using the peroxidase antiperoxidase immunohistochemical technique. Antisera to glutathione peroxidase was raised in a rabbit. Immunoreactive glutathione peroxidase was found to be distributed predominantly in the corneal epithelium and endothelium, choroid, inner segment of photoreceptors and retinal pigmented epithelium. Its presence in these sites suggests an adaptation to oxidative stress where this antioxidant enzyme along with other antioxidant systems serves to prevent damage.
authors.affiliation: Estelle Doheny Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles.
authors.forename: L R
authors.initials: LR
authors.lastname: Atalla
authors.forename: A
authors.initials: A
authors.lastname: Sevanian
authors.forename: N A
authors.initials: NA
authors.lastname: Rao
mesh_terms: D000818:Animals; D002829:Choroid / Q000201:enzymology; D003315:Cornea / Q000201:enzymology; D004728:Endothelium, Corneal / Q000201:enzymology; D004848:Epithelium / Q000201:enzymology; D005123:Eye / Q000201:enzymology*; D005979:Glutathione Peroxidase / Q000032:analysis*; D007124:Immunoenzyme Techniques; D010786:Photoreceptor Cells / Q000201:enzymology; D010857:Pigment Epithelium of Eye / Q000201:enzymology; D011817:Rabbits; D051381:Rats; D011917:Rats, Inbred Lew; D012160:Retina / Q000201:enzymology
chemical_list: D005979:Glutathione Peroxidase