title: Lens transmission and autofluorescence in renal disease.
abstract: Autofluorescence and transmission values of the lens for blue-green light were determined at two locations with the use of identical fluorophotometers: in Coimbra, Portugal, in 44 healthy controls, 15 haemodialysis and 11 renal failure patients, and in Leiden, The Netherlands, in 57 healthy controls, 23 haemodialysis and 47 renal transplant patients. The increase in lens autofluorescence as a function of age was 42% higher in the Portuguese controls than that in the Dutch controls (p less than 0.001), but the lens transmission did not differ significantly (p = 0.21). Significant differences were found between the autofluorescence values of the Portuguese haemodialysis and renal failure patients and those of age-matched local controls (+18%, p = 0.009, and +26%, p = 0.03, respectively), as well as between the lens transmission values of the Portuguese renal failure patients and those of age-matched local controls (-2%, p = 0.03). In the renal transplant patients the average autofluorescence and lens transmission values were equal to those of the local controls (within 3%) and independent of the number of anti-rejection treatments administered.
authors.affiliation: Department of Ophthalmology, Leiden University Medical Center, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: van Wirdum
authors.forename: M C
authors.initials: MC
authors.lastname: Mota
authors.forename: J A
authors.initials: JA
authors.lastname: van Best
authors.forename: E
authors.initials: E
authors.lastname: Leite
authors.forename: J P
authors.initials: JP
authors.lastname: Kappelhof
authors.forename: J R
authors.initials: JR
authors.lastname: Faria de Abreu
authors.forename: L C
authors.initials: LC
authors.lastname: Paul
authors.forename: J
authors.initials: J
authors.lastname: Freitas Martins
authors.forename: J A
authors.initials: JA
authors.lastname: Oosterhuis
authors.forename: A
authors.initials: A
authors.lastname: Marques
mesh_terms: D005453:Fluorescence; D005470:Fluorometry; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology* / Q000628:therapy; D016030:Kidney Transplantation; D007908:Lens, Crystalline / Q000502:physiology*; D008027:Light; D010783:Photometry; D006435:Renal Dialysis