Involvement of Mac-1 antigen in tumor cell killing by macrophages.
Some tumor cells such as YAC-1 and RL male 1 were killed by mouse peritoneal macrophages elicited with OK-432 one day before the harvest. The killing reactions were inhibited specifically by anti-Mac-1. The results suggest that some macrophages generated early after the injection of OK-432 kill tumor cells with the aid of CR3.
Okuda
T
T
Department of Immunology, Tohoku University, Sendai.
Tachibana
T
T
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000943:Antigens, Differentiation / Q000276:immunology*; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D008262:Macrophage Activation; D016177:Macrophage-1 Antigen; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D016177:Macrophage-1 Antigen