[Antibacterial activity of human cervical mucus].
The antibacterial activity of human cervical mucus in non pregnant or pregnant women were investigated employing the standard blood agar plates. Antibacterial activity of lysozyme and combined effect of lysozyme with cefmetazole (CMZ) were also investigated. The results obtained are summarized as follows: 1. Cervical mucus had an antibacterial activity against Bacillus subtilis, but had no antibacterial activity to any other organisms tested. When cervical mucus was heated at 100 degrees C for 5 minutes, its antibacterial activity was lost. 2. Antibacterial activity of cervical mucus combined with CMZ were obtained against Streptococcus pyogenes only, and no effect was observed against other organisms. 3. Lysozyme had an antibacterial activity against Escherichia coli, B. subtilis, Staphylococcus aureus, Bacteroides fragilis, but when combined with CMZ no antibacterial activity was observed.
Chimura
T
T
Department of Obstetrics and Gynecology, School of Medicine, Yamagata University.
Nakahara
M
M
D000328:Adult; D001407:Bacillus / Q000254:growth & development; D015311:Cefmetazole / Q000494:pharmacology; D002582:Cervix Mucus / Q000502:physiology*; D004926:Escherichia coli / Q000254:growth & development; D005260:Female; D006801:Humans; D009113:Muramidase / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000254:growth & development*; D013291:Streptococcus / Q000254:growth & development*
D015311:Cefmetazole; D009113:Muramidase