Zinc deficiency and lymphocyte subpopulations. A study by flow cytometry.
Zinc deficiency is well known to alter immunity. We report the case of a 18-yr-old female with relapsing Crohn's disease who experienced acrodermatitis enteropathica due to zinc deficiency during total parenteral nutrition (TPN). Blood lymphocytes have been studied by flow cytometry: before zinc treatment an important decrease of T-helper lymphocytes with high level of OKM-5+ lymphocytes had been observed. Zinc-supplemented diet induced within a few days, a rise of T-helper lymphocytes and a proportional reduction of OKM5+ cells. Increased values of high metabolism surface marker (OKT-9) were also observed, as well as cytoplasmic modifications. The authors suggest that lymphocyte surface markers could be useful to monitor TPN in patients at high risk for zinc deficiency.
Couvreur
Y
Y
Quarre
J P
JP
Bailly
A
A
Cornut
P
P
D000169:Acrodermatitis / Q000209:etiology; D000293:Adolescent; D000911:Antibodies, Monoclonal; D003424:Crohn Disease / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008214:Lymphocytes / Q000145:classification* / Q000276:immunology; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D015032:Zinc / Q000172:deficiency*
D000911:Antibodies, Monoclonal; D015032:Zinc