[Infections and bone marrow autograft carried out for leukemias in children. Apropos of 47 cases].
This study included 44 children undergoing autologous marrow transplantation for leukemia between August 1979 and June 1987. Three of them received a second transplant. In the phase of neutropenia, 38 children presented with fever. Nineteen septicemia occurred (13 Gram positive cocci, 6 Gram negative bacteria), and 2 interstitial pneumonitis were observed. All children with documented infection or a fever of unknown origin recovered after treatment, except 3, who died from infection. The latest antimicrobial therapy used was a combination of an aminoglycoside and a third generation cephalosporin. When necessary, vancomycin or amphotericin B were added. After engraftment (granulocyte count greater than 0.5 X 10(9)/l) 14 septicemia (which recovered) and 10 herpes zoster infections were observed. Only one patient died of infection (herpes zoster with encephalitis).
Amsallem
D
D
Unité d'Hématologie Pédiatrique, Centre de Transfusion Sanguine, CHU, Besançon.
Plouvier
E
E
Estavoyer
J M
JM
Leroy
J
J
Talon
D
D
Lab
M
M
Hervé
P
P
Noir
A
A
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control*; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000601:surgery*; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D013242:Sterilization; D014777:Virus Diseases / Q000188:drug therapy / Q000209:etiology
D000900:Anti-Bacterial Agents
Infections et autogreffes de moelle osseuse réalisées pour leucémies chez l'enfant. A propos de 47 observations.