Possible involvement of protein kinase C in interleukin-1 production by mouse peritoneal macrophages.
Both lipopolysaccharide (LPS) and phorbol-12,13-dibutyrate (PDBu), a protein kinase C-activating phorbol ester, induced interleukin-1 (IL-1) production in mouse peritoneal macrophages. Prolonged treatment of the cells with PDBu led to the down-regulation and complete disappearance of protein kinase C. In these cells, PDBu did not increase IL-1 production, but LPS still stimulated IL-1 production although the maximum level was slightly reduced. These results suggest that protein kinase C and another unknown signal pathway are involved in LPS-induced IL-1 production.
Katakami
Y
Y
Nakao
Y
Y
Matsui
T
T
Koizumi
T
T
Kaibuchi
K
K
Takai
Y
Y
Fujita
T
T
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002273:Carcinogens / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D007375:Interleukin-1 / Q000096:biosynthesis*; D008050:Lipid A / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D010529:Peritoneal Cavity / Q000166:cytology; D015240:Phorbol 12,13-Dibutyrate; D010703:Phorbol Esters / Q000494:pharmacology; D011493:Protein Kinase C / Q000378:metabolism*
D002273:Carcinogens; D007375:Interleukin-1; D008050:Lipid A; D008070:Lipopolysaccharides; D010703:Phorbol Esters; D015240:Phorbol 12,13-Dibutyrate; D000001:Calcimycin; D011493:Protein Kinase C