Guinea pig copeptin. The glycopeptide domain of the vasopressin precursor.
The vasopressin precursor is composed of 3 domains in line, namely vasopressin, MSEL-neurophysin and a glycopeptide referred to as copeptin, which are separated during the processing. In guinea pig neurohypophysis, the precursor is partially processed so that a two-domain fragment, MSEL-neurophysin--copeptin, can be found along with free MSEL-neurophysin adn copeptin. Guinea pig copeptin has been sequenced. It is a glycopeptide composed of 38 amino acid residues rather than the 39 found in other mammalian copeptins. Compared with other copeptins, that from guinea pig shows a few substitutions and the deletion of one acidic residue, probably in position 32. This deletion might be responsible for incomplete cleavage by the trypsin-like processing enzyme.
Chauvet
M T
MT
Chauvet
J
J
Acher
R
R
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002241:Carbohydrates / Q000032:analysis; D002918:Chymotrypsin; D006020:Glycopeptides / Q000032:analysis*; D006168:Guinea Pigs; D010434:Pepsin A; D010446:Peptide Fragments / Q000032:analysis; D010904:Pituitary Gland, Posterior / Q000032:analysis*; D013045:Species Specificity; D014357:Trypsin
D000596:Amino Acids; D002241:Carbohydrates; D006020:Glycopeptides; D010446:Peptide Fragments; C048197:copeptins; D002918:Chymotrypsin; D014357:Trypsin; D010434:Pepsin A