Effect of nicardipine on angiotensin II platelet content.
We evaluated the effect of nicardipine treatment on platelet angiotensin II content in 18 essential hypertensive patients. Nicardipine induced a decrease in platelet angiotensin II content in all patients (-14%), but particularly in 10 (P less than 0.05; -20.5%). No other differences were found between these patients and the others. Further investigations are required to determine whether platelet angiotensin II content reduction contributes to the prophylactic and therapeutic effects of calcium antagonists on atherosclerosis.
Ferri
C
C
Università di Roma La Sapienza, Istituto di l Clinica Medica, Rome, Italy.
De Angelis
C
C
Del Porto
M A
MA
Leonetti Luparini
R
R
Giarrizzo
C
C
Santucci
A
A
Balsano
F
F
D000368:Aged; D000804:Angiotensin II / Q000032:analysis*; D001792:Blood Platelets / Q000032:analysis*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009529:Nicardipine / Q000494:pharmacology*; D013997:Time Factors
D000804:Angiotensin II; D009529:Nicardipine