[A fatal case of skin cancer 18 years after cadaveric donor renal transplantation].
A 39 years old man was admitted with chronic renal failure, and in June, 1968, he received renal transplantation from a cadaveric donor, 30 years old male, died from cerebral contusion. The graft had been well functioning for 18 years, and he had been engaged in his occupation. At the age of fifty-seven skin cancer (squamous cell carcinoma) occurred in his face, and surgical treatment was carried out. But it metastasized to left parotid, bilateral lungs and other areas of skin, and he died in October 1986, complicated by cerebral infarction. Some reports mention that the incidence of malignancies in posttransplant patients is greater than in general population. Our study reveals that immunological surveillance is weakened in posttransplant patients because of decrease of NK activity, but that the incidence of malignancies (male 0.78%, female 0.45%) is not so great as that reported. There is need of further investigation in this problem.
Arita
S
S
Second Department of Surgery, Chiba University, Faculty of Medicine, Japan.
Asano
T
T
Enomoto
K
K
Nagata
M
M
Goto
T
T
Ochiai
T
T
Isono
K
K
D000328:Adult; D002102:Cadaver; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology; D013997:Time Factors; D014181:Transplantation Immunology