title: Myocardial biosynthesis of prostacyclin and the influence of cardiac loading and drugs.
abstract: Cardiac tissue from different parts of hearts from guinea pigs and rabbits have the capacity to rapidly synthesize prostacyclin (PGI2). Auricles show a higher PGI2-formation than ventricles. Addition of the endoperoxide PGH2 markedly enhanced the myocardial PGI2-biosynthesis. Furthermore many cardiotonic drugs induced a significant rise, but eicosanoids or cyclooxygenase inhibitors a marked reduction of the cardiac PGI2-formation. Acute pressure overload by graduated aortic stenosis, ischemia by coronary ligation or pacing with high frequency reduced the cardiac contractility. After aortic stenosis the myocardial PGI2-biosynthesis is lowered, but increased after coronary ligation or pacing. Under these conditions indomethacin, PGE1, iloprost, verapamil and trapidil markedly reduced the PGI2-biosynthesis and exert a protective effect in regard to cardiac damage. The results indicate that pathophysiological changes significantly influence the PGI2-biosynthesis of the heart. The drug induced inhibition of the myocardial PGI2-formation parallels a cardioprotective effect of these substances.
authors.affiliation: Department of Pharmacology and Toxicology, Martin Luther University Halle-Wittenberg, GDR.
authors.forename: P
authors.initials: P
authors.lastname: Mentz
authors.forename: K E
authors.initials: KE
authors.lastname: Pawelski
authors.forename: C
authors.initials: C
authors.lastname: Giessler
authors.forename: H J
authors.initials: HJ
authors.lastname: Mest
authors.forename: F
authors.initials: F
authors.lastname: Mannes
authors.forename: S
authors.initials: S
authors.lastname: Rotzoll
mesh_terms: D000818:Animals; D001024:Aortic Valve Stenosis / Q000378:metabolism; D002110:Caffeine / Q000494:pharmacology; D003327:Coronary Disease / Q000378:metabolism; D011464:Epoprostenol / Q000096:biosynthesis*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006352:Heart Ventricles / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D010099:Oxyfedrine / Q000494:pharmacology; D011817:Rabbits; D012016:Reference Values; D014192:Trapidil / Q000494:pharmacology
chemical_list: D002110:Caffeine; D010042:Ouabain; D011464:Epoprostenol; D010099:Oxyfedrine; D014192:Trapidil; D007545:Isoproterenol