[The action of obzidan and oktadin on muscle blood flow during head-down tilt hypokinesia].
The blood flow in the gastrocnemius muscle of healthy men was studied during 6-hour antiorthostatic hypokinesia at different angles (-7, -15, -22, -30 degrees) and also the possibility of correcting changes in hemodynamics during antiorthostatic hypokinesia was determined. The muscle blood flow was studied by the clearance method. A total of 72 tests were performed. The tested men received obsidan and octadine 30 minutes before taking the antiorthostatic position in doses of 80 and 12.5 mg for one intake respectively. The analysis of the clinical data showed that typical symptomatology develops during antiorthostatic hypokinesia with a significant decrease of the tissue blood flow in the gastrocnemius muscle at an increase of the angle of tilt. The results of the studies suggested that obsidan fails to improve the muscle blood flow and octadine leads to a greater slowing of the muscle blood flow that negatively influences the condition of the gastrocnemius muscle.
Makoeva
L D
LD
Li
E D
ED
Musev
V A
VA
Memetov
K A
KA
Belinskaia
T F
TF
D006145:Guanethidine / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D009132:Muscles / Q000098:blood supply / Q000187:drug effects*; D011187:Posture; D011433:Propranolol / Q000494:pharmacology*; D011865:Radioisotope Dilution Technique; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D011433:Propranolol; D006145:Guanethidine
Deĭstvie obzidana i oktadina na myshechnyĭ krovotok v usloviiakh antiortostaticheskoĭ gipokinezii.