Azathioprine as a single drug or in combination with steroids in the treatment of myasthenia gravis.
Azathioprine (Aza) has been used alone or in combination with steroids for two groups of myasthenic patients. Positive responses were noted in 75% of patients on Aza alone and in 70% receiving the combined regimen. The clinical course of the two groups differed in terms of respiratory crisis and need for plasma exchange. With an appropriate Aza administration schedule side-effects were not a limiting factor to its use. Aza treatment induced a reduction in anti-AchR-antibody level that was correlated with clinical improvement and greatly decreased the need for steroids.
Mantegazza
R
R
Department of Neuromuscular Diseases, Istituto Neurologico C.Besta, Milan, Italy.
Antozzi
C
C
Peluchetti
D
D
Sghirlanzoni
A
A
Cornelio
F
F
D000328:Adult; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D009157:Myasthenia Gravis / Q000188:drug therapy* / Q000276:immunology; D013256:Steroids / Q000009:adverse effects / Q000627:therapeutic use*
D013256:Steroids; D001379:Azathioprine