An analysis of the effects of increasing doses of ionizing radiation to the exteriorized rat ovary on follicular development, atresia, and serum gonadotropin levels.
There is increasing interest in the effects of environmental and therapeutic agents on the reproductive system, in particular, the ovary. To study the effects of controlled doses of ionizing radiation to the ovary, Sprague-Dawley rats had their ovaries exteriorized and subjected to increasing doses of radiation. There was a significant increase in ovarian follicular atresia, a significant increase in serum follicle-stimulating hormone levels, but no change in serum luteinizing hormone levels. This experimental protocol may facilitate the testing putative radioprotectants.
Jarrell
J
J
YoungLai
E V
EV
Barr
R
R
O'Connell
G
G
Belbeck
L
L
McMahon
A
A
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D005496:Follicular Atresia / Q000528:radiation effects*; D005498:Follicular Phase / Q000528:radiation effects*; D007986:Luteinizing Hormone / Q000097:blood; D006080:Ovarian Follicle / Q000502:physiology / Q000528:radiation effects*; D010053:Ovary / Q000528:radiation effects*; D011829:Radiation Dosage; D051381:Rats; D011919:Rats, Inbred Strains
D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone