In vitro production of colony-stimulating factors by Listeria-immune spleen cells.
In this series of experiments we have shown that there are at least two mechanisms of CSF production by spleen cells in vitro: nonspecific secretion of CSF by nonimmune cells and immune, antigen-driven production by specific T-lymphocytes. M-CSF was mainly produced in the nonspecific reaction. The immune production by T-lymphocytes consisted of increased CSF production and secretion of multiple species of CSFs.
Magee
D M
DM
University of Pittsburgh School of Medicine, PA 15213.
Wing
E J
EJ
D000818:Animals; D003114:Colony-Forming Units Assay; D003115:Colony-Stimulating Factors / Q000096:biosynthesis*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000096:biosynthesis; D008088:Listeriosis / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D012486:Salmonella typhimurium / Q000276:immunology; D013154:Spleen / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D016178:Granulocyte-Macrophage Colony-Stimulating Factor