Metal complexes of mitomycins.
The preparation of stable complexes between the N7-[2-(2-pyridyl)ethyl] and N7-(2-piperazinylethyl) derivatives of mitomycin C and metal ions such as Cu(II), Zn(II), and Pt(II) was accomplished. Mitomycin C did not form stable complexes, but it rearranged to a mitosene capable of complex formation. Some of these complexes had antitumor activity in mice. However, they were less active than mitomycin C. Weak associations between mitomycin C and metal ions were demonstrated by 13C and 15N NMR spectrometry.
Iyengar
B S
BS
Takahashi
T
T
Remers
W A
WA
Bradner
W T
WT
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002712:Chlorides; D003300:Copper; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D016685:Mitomycin; D008937:Mitomycins / Q000138:chemical synthesis* / Q000627:therapeutic use; D010984:Platinum; D017671:Platinum Compounds; D015032:Zinc; D017967:Zinc Compounds
D002712:Chlorides; D008937:Mitomycins; D017671:Platinum Compounds; D017967:Zinc Compounds; C030173:platinum chloride; D010984:Platinum; D016685:Mitomycin; D003300:Copper; C016837:zinc chloride; D015032:Zinc; C029892:cupric chloride