title: Determination of batroxobin levels in the plasma of guinea pigs after epicutaneous and intravenous applications.
abstract: An enzyme immunoassay has been set up to measure batroxobin levels in plasma. This assay allowed the detection of amounts of batroxobin greater than 0.5 ng/ml plasma. After the epicutaneous application of 50 or 100 batroxobin units (BU)/kg body weight, no batroxobin could be detected in plasma samples taken 15, 30, 60, 120 or 240 min after the start of the experiment. In contrast, batroxobin could be detected in plasma samples after i.v. injection of 10 BU/kg body weight.
authors.affiliation: Pentapharm Ltd., Basle, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Meier
authors.forename: C
authors.initials: C
authors.lastname: Adler
authors.forename: N
authors.initials: N
authors.lastname: Weiss
mesh_terms: D000818:Animals; D012103:Batroxobin / Q000008:administration & dosage / Q000097:blood*; D006168:Guinea Pigs; D007124:Immunoenzyme Techniques; D007275:Injections, Intravenous; D008297:Male; D012697:Serine Endopeptidases / Q000097:blood*; D012869:Skin Absorption
chemical_list: D012103:Batroxobin; D012697:Serine Endopeptidases