title: Mixed-ligand complexes of platinum(II) as curing agents for pBR322 and pBR329 (ColE1) plasmids in Escherichia coli.
abstract: The mixed-ligand complexes of platinum(II) [Pt(Gly)(uracil)Cl2].H2O and [Pt(His)(adenine)]-Cl.2H2O eliminated multicopy plasmids with the ColE1 origin of replication in Escherichia coli with 100% frequency. However, plasmids of the IncF1, H1 and X groups were totally refractory to these agents under similar conditions.
authors.affiliation: I. Department of Microbiology, Osmania University, Andhra Pradesh, India.
authors.forename: V V
authors.initials: VV
authors.lastname: Lakshmi
authors.forename: P
authors.initials: P
authors.lastname: Sridhar
authors.forename: B T
authors.initials: BT
authors.lastname: Khan
authors.forename: H
authors.initials: H
authors.lastname: Polasa
mesh_terms: D004926:Escherichia coli; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D010957:Plasmids / Q000187:drug effects*
chemical_list: D008024:Ligands; D009944:Organoplatinum Compounds; C059575:histidinatoadenine platinum(II); C059574:dichloroglycineuracil platinum(II)