title: Early enteral feeding does not affect the incidence of necrotizing enterocolitis.
abstract: To begin to determine the optimal time for initiating enteral feedings, 34 sick, very low birth weight infants were prospectively selected from all neonates of less than 1,500 g (N = 116) and randomly divided into two groups. Infants were fed either on day 1 (early) or 7 (late) of life, according to a feeding protocol which included parenteral nutrition and a scheduled progression from sterile water to 2.5% dextrose, half-strength, and finally full-strength formula over seven days. The incidence of necrotizing enterocolitis and subsequent hospital course were compared. Initiating enteral feedings on day 1 did not significantly increase the incidence of necrotizing enterocolitis, produce a clustering of cases, or induce an earlier onset of necrotizing enterocolitis. The overall incidence of necrotizing enterocolitis in sick, very low birth weight neonates was 29% (5/17) and 35% (6/17) in the early and late groups, respectively, compared with 4.2% (2/47) in minimally sick, very low birth weight neonates. No significant differences between groups were seen in obstetrical complications, birth weight, gestational age, Apgar scores, presence of patent ductus arteriosus or intraventricular hemorrhage, use of umbilical catheterization, and respiratory or oxygen requirements. Infants fed enterally from day 1 did show a significantly higher energy and protein intake during the second week of life. These data show that providing dilute, early enteral calories does not adversely affect the incidence of necrotizing enterocolitis.
authors.forename: S G
authors.initials: SG
authors.lastname: Ostertag
authors.forename: E F
authors.initials: EF
authors.lastname: LaGamma
authors.forename: C E
authors.initials: CE
authors.lastname: Reisen
authors.forename: F L
authors.initials: FL
authors.lastname: Ferrentino
mesh_terms: D004750:Enteral Nutrition / Q000379:methods; D004761:Enterocolitis, Pseudomembranous / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000628:therapy; D008297:Male; D009519:New York City; D010288:Parenteral Nutrition; D011446:Prospective Studies; D011897:Random Allocation; D012189:Retrospective Studies; D012306:Risk; D013997:Time Factors