title: Pantothenic acid transport and metabolism in the central nervous system.
abstract: The mechanisms by which pantothenic acid (PA) enters and leaves brain, choroid plexus, and cerebrospinal fluid (CSF) were investigated by injecting [3H]PA either intravenously or intraventricularly into adult rabbits. [3H]PA, either alone or together with unlabeled PA, was infused at a constant rate into conscious rabbits. At 180 min, [3H]PA readily entered CSF, choroid plexus, and brain. In brain, CSF, and plasma, greater than 90% of the 3H was associated with [3H]PA. The addition of 200 mumol/kg PA to the infusion syringe decreased the penetration of [3H]PA into brain and CSF by approximately 70%. Two hours after the intraventricular injection of [3H]PA, [3H]PA was rapidly cleared from the CSF by a probenecid-sensitive mechanism. No metabolism of the [3H]PA occurred in brain. However, 18 h after the intraventricular injection of 37 microCi (34 nmol) of [3H]PA, approximately 40% of the 3H remaining in forebrain was converted to [3H]CoA. These results show that PA enters and leaves CSF and brain by saturable transport systems. However, [3H]PA is very slowly converted to [3H]CoA in brain in vivo.
authors.forename: R
authors.initials: R
authors.lastname: Spector
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D001921:Brain / Q000378:metabolism*; D002831:Choroid Plexus / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003065:Coenzyme A / Q000031:analogs & derivatives / Q000378:metabolism; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008353:Mannitol / Q000008:administration & dosage / Q000494:pharmacology; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000378:metabolism*; D011817:Rabbits; D013997:Time Factors
chemical_list: D010205:Pantothenic Acid; C015787:dephosphocoenzyme A; D008353:Mannitol; D003065:Coenzyme A