[Determination of cell proliferation using monoclonal antibodies. Studies of 21 squamous cell carcinomas of the head and neck area].
These tumours showed a correlation between Ki 67 labelling index and histological differentiation: poor differentiation resulted in a Ki 67 labelling index from 30 to 50%, high differentiation below 20%. Labelling index of moderately differentiated carcinomas ranged between these values. Pretreatment of tumours, i.e. chemotherapy and radiotherapy, resulted in a labelling index of less than 6%. The observed heterogeneity must be considered as a limitation for using the monoclonal antibody Ki 67 in these cases as a prognostic marker.
Lörz
M
M
Zentrum Hals-Nasen-Ohren-Heilkunde, Johann-Wolfgang-Goethe-Universität Frankfurt/Main.
Meyer-Breiting
E
E
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002455:Cell Division; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D015843:Serpins
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D015843:Serpins; C051072:squamous cell carcinoma-related antigen
Bestimmung der Zellproliferation mit Hilfe monoklonaler Antikörper. Untersuchungen an 21 Plattenepithelkarzinomen aus dem Kopf-Hals-Bereich.