Acidosis and ischemic brain damage.
It is now widely accepted that acidosis is an important component of the pathogenetic events that lead to ischemic brain damage. The objective with this article is to recall the evolution of the concept, to describe the conditions under which tissue acidosis arises and causes enhanced brain damage, and to probe into the cellular and molecular mechanisms involved.
Siesjö
B K
BK
Laboratory for Experimental Brain Research, University of Lund, Sweden.
D000140:Acidosis, Lactic / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000473:pathology; D001929:Brain Edema / Q000503:physiopathology; D002545:Brain Ischemia / Q000209:etiology* / Q000503:physiopathology; D002118:Calcium / Q000502:physiology; D002560:Cerebrovascular Circulation; D005609:Free Radicals; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000032:analysis; D051381:Rats; D012640:Seizures / Q000503:physiopathology
D005609:Free Radicals; D007773:Lactates; D002118:Calcium