title: Alterations in lipid metabolism induced by antihypertensive therapy.
abstract: Adverse effects on serum triglycerides and cholesterol fractions have been reported in hypertensive patients treated with diuretics and non-selective beta-blockers. However, the changes induced by cardioselective beta-blockers and those with intrinsic sympathomimetic activity (ISA) or by alpha-blockers have been shown to be more favourable. In addition, evidence suggests that calcium antagonists and angiotensin-converting enzyme (ACE) inhibitors have little effect on serum lipid concentrations in hypertensive patients, although until now only diuretics and beta-blockers without ISA have been shown to reduce morbidity and mortality.
authors.affiliation: Department of Pathophysiology, Catholic University of Leuven, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Amery
authors.forename: P
authors.initials: P
authors.lastname: Lijnen
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects*; D002784:Cholesterol / Q000097:blood*; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D014280:Triglycerides / Q000097:blood*
chemical_list: D000959:Antihypertensive Agents; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol