Low levels of gamma-aminobutyric acid in cerebrospinal fluid of dogs with epilepsy.
gamma-Aminobutyric acid (GABA) levels were determined in cisternal cerebrospinal fluid (CSF) of 19 epileptic dogs with generalized tonic-clonic (grand mal) seizures using a radioreceptor assay. Thirty-four healthy age-matched dogs served as controls. The average CSF GABA level in epileptic dogs (40 pmol/ml) was significantly lower than that determined in controls (66 pmol/ml). Treatment with phenobarbital or primidone seemed not to affect CSF GABA levels.
Löscher
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W
Schwartz-Porsche
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D
D000818:Animals; D004285:Dogs; D004830:Epilepsy, Tonic-Clonic / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D005260:Female; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use; D011324:Primidone / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000134:cerebrospinal fluid*
D011324:Primidone; D005680:gamma-Aminobutyric Acid; D010634:Phenobarbital