title: [Long-term treatment of hypertension with a selective beta l-blocker without sympathomimetic activity. I. Antihypertensive and hemodynamic effects].
abstract: The antihypertensive and hemodynamic efficacy of Betaloc (Egys-Hungary) was studied in 30 hypertensive patients in the II stage of the disease. The drug was applied in a single daily dose of 100 mg in the course of 6 months. The systolic and diastolic pressure and the heart rate decreased reliably (p less than 0.0001) at the end of the first month. The stroke volume increased (p less than 0.045) at the end of the sixth month but the minute volume and the cardiac index did not change (p greater than 0.32). The peripheral vascular resistance dicreased reliably (p less than 0.02) at the end of the sixth month--the degree depending on the initial type of circulation--and it determined the longstanding antihypertensive efficacy of Betaloc. No untoward reactions were registered.
authors.forename: V
authors.initials: V
authors.lastname: Sirakova
authors.forename: N
authors.initials: N
authors.lastname: Penkov
authors.forename: Kh
authors.initials: Kh
authors.lastname: Kaponov
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008790:Metoprolol / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D013997:Time Factors
chemical_list: D008790:Metoprolol
vernacular_title: Dŭlgotraĭno lechenie na khipertonichnata bolest sŭs selektiven beta 1-bloker bez simpatikomimetichna aktivnost. I. Antikhipertenziven i khemodinamichen efekt.