A new case of chronic myelogenous leukemia with 14q+ marker and review of the literature.
We report a new case of Ph 1 positive chronic myelogenous leukemia (CML) with 14q+ marker shown during chronic phase (CP) and subsequently in blastic crisis (BC). After a review of the literature, we discuss the biological significance of 14q+ marker in developing lymphoid cellular differentiation, during evolution of CML, that remains still unclear. Besides, we also discuss the prognostic value of this change, concluding that a larger number of cases may clarify this question, as also the unresponsivity to chemotherapy of the patient studies so far, may not be related to 14q+ marker.
Palka
G
G
Institute of Biology and Genetics, University of Chieti, Italia.
Geraci
L
L
Calabrese
G
G
Stuppia
L
L
Guanciali Franchi
P
P
Parruti
G
G
D'Antonio
D
D
Fioritoni
G
G
D000328:Adult; D002883:Chromosomes, Human, Pair 14; D005819:Genetic Markers; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D010677:Philadelphia Chromosome
D005819:Genetic Markers