[Protection of the pulmonary toxic effects of normobaric oxygen by inducers of cytochrome P450-linked monooxygenases].
Inducers of cytochrome P450-linked mono-oxygenases increase the normobaric oxygen tolerance of the adult rat. Pulmonary inducers, as 3-methylcholanthrene and beta-naphthoflavone permit the rat survival and simultaneously a decrease of pulmonary edema. Phenobarbital, an hepatic inducer had lesser effects both on survival rate and on pulmonary and lymphoïd oxygen toxicity.
Mansour
H
H
Brun-Pascaud
M
M
Gougerot-Pocidalo
M A
MA
Pocidalo
J J
JJ
D000818:Animals; D001571:Benzoflavones / Q000627:therapeutic use; D003577:Cytochrome P-450 Enzyme System; D004790:Enzyme Induction / Q000187:drug effects*; D008748:Methylcholanthrene / Q000627:therapeutic use; D010100:Oxygen / Q000037:antagonists & inhibitors* / Q000633:toxicity; D010105:Oxygenases / Q000096:biosynthesis*; D010634:Phenobarbital / Q000627:therapeutic use; D011654:Pulmonary Edema / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D019324:beta-Naphthoflavone
D001571:Benzoflavones; D008748:Methylcholanthrene; D019324:beta-Naphthoflavone; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D010100:Oxygen; D010634:Phenobarbital
Protection des effets toxiques pulmonaires de l'oxygène normobare par les inducteurs enzymatiques des mono-oxygénases liés au cytochrome P450.