title: Enhancement of host resistance against Salmonella typhimurium infection by a diet supplemented with yogurt.
abstract: The effect of a diet supplemented with yogurt containing live lactobacilli (LAB) - Lactobacillus bulgaricus and Streptococcus thermophilus - on the response of inbred mice to infection with Salmonella typhimurium was elaborated. The results of our experiments were consistent with the hypothesis that modifications of the microflora influence the adherence of S. typhimurium to intestinal mucosa, the natural antibacterial activity of the Peyer's patches lymphocytes, the accumulation of the macrophages in the liver, the proliferative responses of the splenocytes. The relationship between modifications of the immune response following ingestion of yogurt with live LAB and increased defense mechanisms was confirmed by the bacterial counts in livers and spleens and by the reduced mortality to S. typhimurium infection.
authors.affiliation: Clinica Malattie Infettive, Università La Sapienza, Roma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: De Simone
authors.forename: S
authors.initials: S
authors.lastname: Tzantzoglou
authors.forename: L
authors.initials: L
authors.lastname: Baldinelli
authors.forename: S
authors.initials: S
authors.lastname: Di Fabio
authors.forename: B
authors.initials: B
authors.lastname: Bianchi-Salvadori
authors.forename: E
authors.initials: E
authors.lastname: Jirillo
authors.forename: R
authors.initials: R
authors.lastname: Vesely
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion; D003611:Dairy Products; D007113:Immunity, Innate; D007778:Lactobacillus / Q000276:immunology; D008099:Liver / Q000276:immunology / Q000382:microbiology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010581:Peyer's Patches / Q000276:immunology; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D012486:Salmonella typhimurium; D013154:Spleen / Q000276:immunology / Q000382:microbiology; D013291:Streptococcus / Q000276:immunology; D015014:Yogurt