Evaluation of (1-sarcosine, 8-isoleucine) angiotensin II as a therapeutic agent for oleic acid-induced pulmonary edema.
(1-Sarcosine, 8-isoleucine) angiotensin II was assessed as a therapeutic agent for acute respiratory distress syndrome with oleic acid pulmonary edema in sheep used as an experimental model. Under general anesthesia with controlled mechanical ventilation with 100% oxygen, 32 sheep received oleic acid (0.075 ml/kg) intravenously. After oleic acid infusion, 20 animals were treated with continuous intravenous infusion of the angiotensin II analogue; nine received 300 ng/kg/min, six received 600 ng/kg/min, and five received 2000 ng/kg/min. Cardiopulmonary measurements were repeated every 30 minutes for 270 minutes. According to time-integrated PaO2, six of 15 animals of the groups given 300 and 600 ng/kg/min (43%) did not respond to the treatment. All animals responded in the group given 2000 ng/kg/min. Animals in the latter group had lower Qs/Qt, PaCO2, and airway resistance than had the control animals. Elevation of pulmonary vascular resistance was limited and mean arterial blood pressure was well maintained. These results reveal that (1-Sar, 8-Ile) angiotensin II is effective in the treatment of oleic acid-induced pulmonary edema.
Yukioka
T
T
Yukioka
N
N
Aulick
L H
LH
Goodwin
C W
CW
Mason
A D
AD
Sugimoto
T
T
Pruitt
B A
BA
D015059:1-Sarcosine-8-Isoleucine Angiotensin II / Q000627:therapeutic use*; D000804:Angiotensin II / Q000031:analogs & derivatives*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D008168:Lung / Q000473:pathology; D008170:Lung Compliance / Q000187:drug effects; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011652:Pulmonary Circulation / Q000187:drug effects; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy*; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000188:drug therapy; D012756:Sheep; D014655:Vascular Resistance / Q000187:drug effects
D009829:Oleic Acids; D000804:Angiotensin II; D002245:Carbon Dioxide; D019301:Oleic Acid; D015059:1-Sarcosine-8-Isoleucine Angiotensin II; D010100:Oxygen