title: Langerhans cells in verruciform xanthomas: an immunoperoxidase study of 10 oral cases.
abstract: Ten oral verruciform xanthomas were studied using an immunoperoxidase stain for S-100 protein. All cases exhibited positively stained dendritic cells among the mononuclear inflammatory cell infiltrate at the base of the lesions and to a lesser extent among the "foam cells". The foam cells were, however, negative for S-100 staining. We suggest that, based on these findings, verruciform xanthomas belong to a new category of "non-X histiocytoses" in which the presence of Langerhans cells suggests an immunologic pathogenesis.
authors.forename: D
authors.initials: D
authors.lastname: Rowden
authors.forename: G
authors.initials: G
authors.lastname: Lovas
authors.forename: W
authors.initials: W
authors.lastname: Shafer
authors.forename: K
authors.initials: K
authors.lastname: Sheikh
mesh_terms: D005487:Foam Cells / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007801:Langerhans Cells / Q000473:pathology*; D009059:Mouth Diseases / Q000473:pathology*; D009418:S100 Proteins; D014973:Xanthomatosis / Q000473:pathology*
chemical_list: D009418:S100 Proteins