title: 6-Hydroxydopamine and excitotoxin lesions of medial prefrontal cortex fail to affect schedule-induced drinking in the rat.
abstract: Schedule-induced drinking was examined in rats following 6-hydroxydopamine and N-methyl-D-aspartate lesions of the medial prefrontal cortex. 6-Hydroxydopamine reduced the concentrations of dopamine and noradrenaline in the medial prefrontal cortex to 17 and 37% of control values respectively, while changes were not observed in the nucleus accumbens. Lesions with N-methyl-D-aspartate were confined to the medial prefrontal cortex. Schedule-induced water consumption, determined over 11 consecutive 1 h/day testing sessions, was not significantly altered by either lesion. These results suggest that the mesocortical dopaminergic projection to the medial prefrontal cortex, and reciprocal projections from medial prefrontal cortex to the nucleus accumbens and the ventral tegmental area, are not essential for the acquisition of schedule-induced drinking.
authors.forename: M J
authors.initials: MJ
authors.lastname: Christie
authors.forename: P M
authors.initials: PM
authors.lastname: Beart
authors.forename: W J
authors.initials: WJ
authors.lastname: Louis
authors.forename: S J
authors.initials: SJ
authors.lastname: Gibson
authors.forename: G
authors.initials: G
authors.lastname: Singer
authors.forename: M
authors.initials: M
authors.lastname: Papasava
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D001931:Brain Mapping; D004298:Dopamine / Q000502:physiology*; D004327:Drinking Behavior / Q000502:physiology*; D005508:Food Deprivation / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology*; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate; D009434:Neural Pathways / Q000502:physiology; D009714:Nucleus Accumbens / Q000502:physiology; D016627:Oxidopamine; D051381:Rats; D012055:Reinforcement Schedule; D013681:Tegmentum Mesencephali / Q000502:physiology
chemical_list: D006892:Hydroxydopamines; D001224:Aspartic Acid; D016202:N-Methylaspartate; D016627:Oxidopamine; D004298:Dopamine