title: Single-dose ceftriaxone therapy of gonococcal ophthalmia neonatorum.
abstract: Ceftriaxone (125 mg) given as a single intramuscular dose without topical therapy was evaluated in seven infants with smear-positive gonococcal ophthalmia neonatorum. Neisseria gonorrhoeae was isolated from the eyes of six infants, and four of these isolates were penicillinase-producing N. gonorrhoeae. Two infants had concomitant ocular infection with Chlamydia trachomatis. All seven infants, when seen at follow-up, showed marked clinical improvement. Conjunctivitis resolved completely in four infants. One infant was lost to subsequent follow-up, while two infants had persistent ophthalmia due to C. trachomatis. Follow-up eye cultures for N. gonorrhoeae were all negative.
authors.forename: D A
authors.initials: DA
authors.lastname: Haase
authors.forename: R A
authors.initials: RA
authors.lastname: Nash
authors.forename: H
authors.initials: H
authors.lastname: Nsanze
authors.forename: L J
authors.initials: LJ
authors.lastname: D'Costa
authors.forename: L
authors.initials: L
authors.lastname: Fransen
authors.forename: P
authors.initials: P
authors.lastname: Piot
authors.forename: R C
authors.initials: RC
authors.lastname: Brunham
mesh_terms: D002443:Ceftriaxone / Q000008:administration & dosage* / Q000627:therapeutic use; D002584:Cervix Uteri / Q000382:microbiology; D002986:Clinical Trials as Topic; D005123:Eye / Q000382:microbiology; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D009878:Ophthalmia Neonatorum / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D002443:Ceftriaxone