title: [Radiotherapy of cerebral metastases. 196 cases treated from 1973 to 1981].
abstract: One hundred and ninety six patients underwent brain irradiation for metastases between 1973 and 1981. Complete follow-up was possible in 180 cases. CT appeared to be the best diagnostic tool. Whatever the type of the tumor, irradiation improved symptoms and signs in 65.3 p. 100 of cases and neurological status in 37 p. 100 of cases. The median survival was 4.2 months, the mean survival 6.6 months, the percent survival at 1 year 11 p. 100. It is necessary to irradiate the whole brain with doses of 40-45 Gy in 4.5 weeks. Shorter periods of irradiation allows a short inhospital stay but implies anti-oedematous treatment. Chemotherapy did not improve the results. Excision surgery had limited indications: isolated metastases, accessible site in zones with no functional importance, good performance status, local control obtained for primary tumor, no extra-cerebral metastases. Surgery must be followed by whole brain irradiation. Derivation is necessary when increased intracranial pressure and treatment resistance are present. Irradiation indications are large. The results were palliative but valuable: irradiation was always indicated except when disorders of consciousness were present. Tolerance was usually good.
authors.affiliation: Centre Léon Bérard, Service de Radiothérapie, Lyon.
authors.forename: J L
authors.initials: JL
authors.lastname: Chassard
authors.forename: M E
authors.initials: ME
authors.lastname: Zouai
authors.forename: J P
authors.initials: JP
authors.lastname: Gérard
authors.forename: L
authors.initials: L
authors.lastname: Dutou
authors.forename: F
authors.initials: F
authors.lastname: Mornex
authors.forename: M
authors.initials: M
authors.lastname: Lacroze
authors.forename: J M
authors.initials: JM
authors.lastname: Ardiet
authors.forename: F
authors.initials: F
authors.lastname: Chauvin
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage
vernacular_title: La radiothérapie des métastases cérébrales. 196 cas traités de 1973 à 1981.