Metabolism of naphthalene in roosters.
1. The metabolism of naphthalene in roosters was similar to that in rats. At least 45% of the dose was isolated from the urine as metabolites that could be formed from arene oxide precursors. 2. Urine was the major route for excretion (79%) of 14C-naphthalene from colostomized roosters. Roosters with cannulated bile ducts excreted about 24% of the dose in bile. 3. Roosters excreted tetrahydrotrihydroxy mercapturic acids of naphthalene as major urinary metabolites which indicates either the formation of diepoxide intermediates or sequential epoxidation-conjugation processes. 4. The major biliary metabolites in rooster bile were characterized as cysteine and cysteinylglycine conjugates of tetrahydrotrihydroxynaphthalenes.
Bakke
J E
JE
Metabolism and Radiation Research Laboratory, US Department of Agriculture, Fargo, ND 58105.
Davison
K L
KL
D000818:Animals; D001711:Biotransformation; D002250:Carbon Radioisotopes; D002645:Chickens / Q000378:metabolism*; D003125:Colostomy; D008297:Male; D015394:Molecular Structure; D009281:Naphthalenes / Q000378:metabolism / Q000493:pharmacokinetics*; D011865:Radioisotope Dilution Technique; D012016:Reference Values
D002250:Carbon Radioisotopes; D009281:Naphthalenes; C031721:naphthalene