title: Unusual but reversible hepatic lesions following long-term treatment with pyridylcarbinol for familial hypercholesterolemia.
abstract: We report two cases of unusual hepatic lesions following years of monotherapy with pyridylcarbinol (timespan) in a daily dose of 1.35 to 1.5 g for familial hypercholesterolemia. Mild elevations of liver enzymes correlated to a large tumor-like mass in the gallbladder region in one case and nodular changes in the whole liver (diagnosed by ultrasound) similar to metastatic lesions. After discontinuation of pyridylcarbinol the changes in the liver regressed markedly in both cases.
authors.affiliation: Medizinische Poliklinik der Universität München.
authors.forename: C
authors.initials: C
authors.lastname: Keller
authors.forename: W
authors.initials: W
authors.lastname: Zoller
authors.forename: G
authors.initials: G
authors.lastname: Wolfram
authors.forename: N
authors.initials: N
authors.lastname: Zöllner
mesh_terms: D000328:Adult; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy*; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009540:Nicotinyl Alcohol / Q000009:adverse effects* / Q000627:therapeutic use; D011725:Pyridines / Q000009:adverse effects*; D014463:Ultrasonography
chemical_list: D011725:Pyridines; D009540:Nicotinyl Alcohol