Classic and immunodeficiency-associated Kaposi's sarcoma. Clinical, histologic, and immunologic correlations.
The evolutionary modifications of the clinical, histomorphologic, and immunopathologic features of both classic and immunodeficiency (ID)-associated Kaposi's sarcoma (KS) were investigated in relation to the immune status of the patients. The histologic picture was similar in the classic and ID-associated forms of the tumor. In classic KS, a variably dense reactive infiltrate was present, and its amount was inversely related to the age of the lesions; conversely, a scarce reactive infiltrate, with the absence of CD4+ cells, was always evidenced in ID-associated KS lesions, even when the immune status of the patient showed no abnormalities. This evidence supports the hypothesis that a specific impairment of skin-associated lymphoid tissue may be crucial to the development of ID-associated KS.
Santucci
M
M
Istituto di Anatomia e Istologia Patologica, Università degli Studi di Firenze, Italy.
Pimpinelli
N
N
Moretti
S
S
Giannotti
B
B
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D006689:Hodgkin Disease / Q000150:complications; D006801:Humans; D007108:Immune Tolerance; D007150:Immunohistochemistry; D016030:Kidney Transplantation; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications; D007958:Leukocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000145:classification
D000911:Antibodies, Monoclonal