title: Febrile transfusion reaction caused by AB0-incompatible platelet transfusion.
abstract: A febrile transfusion reaction caused by strong isoagglutinins in the patients serum is reported. The reaction resulted from a transfusion of group A platelets in a group 0 patient; the recipients' serum contained high titered isohemagglutinin (Anti-A 1:8192) capable of lysing bloodgroup A1 red cells up to a titer of 1:8. Moreover, the serum showed a strong positive thrombocytotoxic reaction with the platelets of the donor and some other group A individuals, but remained negative with group 0, and turned to negative reaction with group A samples after neutralization with bloodgroup substance. We conclude that pretransfusion testing of group 0 donors and recipients for isohemolysins combined with platelet crossmatching may prevent febrile reactions.
authors.affiliation: Institut für Blutgruppenserologie der Universität Wien, National Blood Group Reference Laboratory (WHO).
authors.forename: P M
authors.initials: PM
authors.lastname: Winter
authors.forename: M
authors.initials: M
authors.lastname: Amon
authors.forename: P
authors.initials: P
authors.lastname: Höcker
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000368:Aged; D001787:Blood Group Incompatibility / Q000235:genetics*; D001803:Blood Transfusion; D001943:Breast Neoplasms / Q000628:therapy*; D017707:Erythrocyte Transfusion; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D017713:Platelet Transfusion
chemical_list: D000017:ABO Blood-Group System