title: Comparison of endocrine and radiation therapy in locally advanced prostatic cancer.
abstract: 151 patients with locally advanced prostatic cancer (T3-4 M0), representing 38% of the 404 cancer patients in a Finnish multicenter study, were randomly assigned to one of three treatment arms: orchiectomy, estrogens or radiotherapy. During the 4-year follow-up period there were no significant differences in the progression rates (appearance of metastases in bone scan) between the therapy groups. The frequency of thromboembolic and other cardiovascular complications was highest in the estrogen group (13/50 patients). In the radiotherapy group, 19 of 45 patients had bowel or bladder complications. On the other hand, orchiectomy has few, if any, complications. The high risk of complications associated with estrogens and radiotherapy has to be taken into consideration in the selection of treatment.
authors.affiliation: Second Department of Surgery, Helsinki University Central Hospital, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Aro
authors.forename: R
authors.initials: R
authors.lastname: Haapiainen
authors.forename: M
authors.initials: M
authors.lastname: Kajanti
authors.forename: S
authors.initials: S
authors.lastname: Rannikko
authors.forename: O
authors.initials: O
authors.lastname: Alfthan
mesh_terms: D000230:Adenocarcinoma / Q000628:therapy*; D000368:Aged; D000369:Aged, 80 and over; D004958:Estradiol / Q000031:analogs & derivatives / Q000627:therapeutic use; D045166:Estradiol Congeners / Q000627:therapeutic use*; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D005387:Finland; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000628:therapy*; D011878:Radiotherapy / Q000379:methods*; D011897:Random Allocation
chemical_list: D045166:Estradiol Congeners; D004997:Ethinyl Estradiol; D004958:Estradiol; C008958:polyestradiol phosphate