title: Regulation of actin gene expression during sea urchin development.
abstract: The progress that has been made in the last several years toward an understanding of the expression of the actin genes of the sea urchin is impressive. It serves as an excellent example of how the application of modern molecular biological techniques to a classic experimental system (the sea urchin embryo) can begin to give us insight into the processes of embryological development. There is reason to hope that general principles will emerge from studies such as these, but many questions are unanswered. With specific regard to the actin genes and proteins, there are some obvious questions. Are the actins encoded by the different genes functionally distinct, and what roles do they play in differentiation and development? How is the expression of each of these genes regulated; i.e., what molecules participate, how do they work, where are they located in the embryo, and when do they appear? The more general question is: How are these (and other) genes and proteins affected by, or how do they contribute to, determination and induction in early development? We hope that answers to the specific questions posed will provide important steps toward answers to the general question.
authors.affiliation: Cell Biology Group, Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545.
authors.forename: W R
authors.initials: WR
authors.lastname: Crain
mesh_terms: D000199:Actins / Q000235:genetics*; D000818:Animals; D005314:Embryonic and Fetal Development / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation; D005810:Multigene Family; D012333:RNA, Messenger / Q000378:metabolism; D012617:Sea Urchins / Q000196:embryology* / Q000235:genetics
chemical_list: D000199:Actins; D012333:RNA, Messenger