Effect of ketorolac on phagocytosis of Candida albicans by peritoneal macrophages.
The effect of ketorolac tromethamine, a nonsteroidal anti-inflammatory drug, on normal phagocytosis has been studied. When peritoneal macrophages, taken from mice treated intraperitoneally 4 times daily for 7 days with 2 mg ketorolac per day, were cultured ex vivo or when untreated macrophages were cultured with 1-10 microM of ketorolac in vitro, the number of engulfed Candida albicans was no different from saline-treated or untreated controls. In contrast, macrophages from mice treated intraperitoneally 4 times daily for 7 days with 0.4 mg dexamethasone per day or cultured with 1-10 microM dexamethasone had a greater than or equal to 54% reduction in phagocytosis (p less than 0.001). Thus, ketorolac is a nonsteroidal anti-inflammatory drug which does not inhibit the phagocytic activity of murine mononuclear phagocytes.
Fraser-Smith
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Syntex Research, Department of Antimicrobial Research, Palo Alto, CA 94303.
Matthews
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D000818:Animals; D002176:Candida albicans / Q000276:immunology*; D003907:Dexamethasone / Q000494:pharmacology; D004338:Drug Combinations / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D007274:Injections, Intraperitoneal; D020911:Ketorolac Tromethamine; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D010533:Peritoneal Lavage; D010587:Phagocytosis / Q000187:drug effects*; D011758:Pyrroles / Q000494:pharmacology*; D014046:Tolmetin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D014325:Tromethamine / Q000008:administration & dosage / Q000494:pharmacology*
D004338:Drug Combinations; D011758:Pyrroles; D014325:Tromethamine; D020911:Ketorolac Tromethamine; D003907:Dexamethasone; D014046:Tolmetin