[Pharmacokinetics of theophylline in children with acute asthmatic crisis].
In order to defined the theophylline dose which produce effective theophylline concentrations with less number of plasmatic controls, we analyzed the theophylline pharmacokinetics of 18 boys and girls between 3-12 year olds of Tarragona, to which we administered 6 mg/kg/6 h of aminophylline by IV intermittent infusion (30 min), following by rapid-release PO aminophylline at the same dose and intervals. In steady-state we did the pharmacokinetic studies at 1 h, 4 h and 6 h after the administration of one dose. The maintenance dose obtained was administered PO as slow-release theophylline, with later controls of theophylline concentration. We found that maintenance dose of 24.1 +/- 4.7 mg/kg/day (mean +/- SD) allowed theophylline concentration between therapeutic levels in the population studied.
Casasín Edo
T
T
Servicio de Farmacia, Hospital Juan XXIII, Tarragona.
Llusa Arbos
M
M
Gómez Papi
A
A
Closa Monasterolo
R
R
Tarrés Roure
A
A
D001249:Asthma / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
D013806:Theophylline
Farmacocinética de la teofilina en niños con crisis asmática aguda.