title: HLA antigens and the antibody response after vaccination to hepatitis B.
abstract: The aim of our work was the search for immunogenetic factors that influence the antibody response to HBs antigen. We analyzed the HLA-A, -B, and -DR antigen frequencies in 19 seropositive to HBs and 28 seronegative to HBs healthy persons finding an elevated frequency of B5 in the seropositive group (p value 0.037). After vaccination with Hevac B Pasteur vaccine of the seronegative persons, the low antibody response was associated with B13 (p value 0.041). An association between local side reactions to the vaccine and HLA A3 and B35 were also found (p values 0.042 and 0.022 respectively). The presented p values are not significant after correction for the number of antigens tested and for this reason our findings require confirmation in an independent study.
authors.affiliation: Department of Clinical Immunology, Polish Academy of Sciences, Wrocław.
authors.forename: H
authors.initials: H
authors.lastname: Matej
authors.forename: B
authors.initials: B
authors.lastname: Nowakowska
authors.forename: J
authors.initials: J
authors.lastname: Pacyńska
authors.forename: A
authors.initials: A
authors.lastname: Gładysz
authors.forename: M
authors.initials: M
authors.lastname: Zalewska
authors.forename: K
authors.initials: K
authors.lastname: Simon
mesh_terms: D000328:Adult; D000917:Antibody Formation; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000097:blood; D015235:HLA-B Antigens / Q000097:blood; D006684:HLA-DR Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D014611:Vaccination; D014761:Viral Hepatitis Vaccines / Q000627:therapeutic use
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D014761:Viral Hepatitis Vaccines