[Electron microscopic study of the interaction of virulent and avirulent Shigella flexneri strains with the macrophages of murine peritoneal exudate].
The electron microscopic dynamic study of the interaction of S. flexneri virulent strain 2a and S. flexneri avirulent strain, genetically related to strain 2a and having the same antigenic structure, with peritoneal macrophages of CBA mice at an early period showed differences in the cytotoxic action of these strains. Even at the early period of the interaction between macrophages and virulent shigellae structural changes were observed in macrophages: ruptures in the membranes of parasitophore phagosomes, the vacuolization of the cytoplasm, the destruction of mitochondria. These changes were indicative of the early cytotoxic action of shigellae belonging to the virulent strain. In macrophages infected with avirulent shigellae the manifestations of this cytotoxicity were less pronounced and appeared later than in macrophages infected with S. flexneri virulent strain.
Kirillova
F M
FM
Kudriavtseva
L Iu
LIu
Popov
V L
VL
Belaia
Iu A
IuA
D000327:Adsorption; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology*; D002478:Cells, Cultured; D008264:Macrophages / Q000382:microbiology* / Q000648:ultrastructure; D051379:Mice; D008808:Mice, Inbred CBA; D008854:Microscopy, Electron; D010587:Phagocytosis; D012763:Shigella flexneri / Q000472:pathogenicity / Q000648:ultrastructure*; D013696:Temperature; D013997:Time Factors; D014774:Virulence
Elektronno-mikroskopicheskoe izuchenie vzaimodeĭstviia virulentnogo i avirulentnogo shtammov Shigella flexneri s makrofagami peritoneal'nogo ékssudata mysheĭ.