title: Pancreatic abnormalities in patients with eating disorders.
abstract: In patients with eating disorders, we evaluated pancreatic abnormalities using serum elastase 1 measurement by RIA and the 50 g oral glucose tolerance test (50 g OGTT). Twenty-one patients had anorexia nervosa (AN) with bulimia and vomiting (AN-B group), 30 had AN without bulimia or vomiting (AN-R group), and 25 had bulimia with normal body weight (B group). The serum elastase 1 level was determined on admission and repeated after body weight gain in 43 anorectic patients. The 50 g OGTT was performed within 2 weeks after admission. The serum elastase 1 level in the AN-B group (363 +/- 47 ng/dl, M +/- SE), and in the AN-R group (352 +/- 37) were significantly higher than that in the B group (242 +/- 18) or in the healthy female controls (191 +/- 10; n = 13). A significant decrease of serum elastase 1 was observed before and after body weight gain; however, there was no significant correlation between the serum elastase 1 level and insulin response to the 50 g OGTT. Elevation of the serum elastase 1 level in AN suggests pancreatic abnormalities other than those related to endocrinological events.
authors.affiliation: Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Tamai
authors.forename: S
authors.initials: S
authors.lastname: Uehata
authors.forename: G
authors.initials: G
authors.lastname: Komaki
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: S
authors.initials: S
authors.lastname: Matsubayashi
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000201:enzymology*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002032:Bulimia / Q000201:enzymology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D010196:Pancreatic Elastase / Q000097:blood; D010186:Pancreatic Function Tests
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010196:Pancreatic Elastase