title: [The so-called lung adenomatosis of sheep--an interesting pneumopathy from the comparative pathologic view].
abstract: Contrary to conditions in human pathology, primary pulmonary neoplasms are rare in animals. The so-called pulmonary adenomatosis of sheep (PAS) is of greater importance among the epithelial lung tumors of domestic animals. PAS is a chronic, lethal pneumopathy caused by an oncogenic retrovirus. It is associated with the category of slow virus infections for its extremely long incubation period. PAS is characterized as a primary multicentric epithelial neoplasm which develops from proliferating alveolar pneumocytes II and non-ciliated bronchial epithelial cells. It has been recently classified as broncho-alveolar carcinoma on account of its morphological features and occasional metastasis into bronchial and mediastinal lymph nodes. PAS because of its similarity with human pulmonary carcinoma may be used as a model pneumopathy in comparative oncology.
authors.affiliation: Wissenschaftsbereich Pathologie, Karl-Marx-Universität Leipzig, DDR.
authors.forename: U
authors.initials: U
authors.lastname: Johannsen
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000209:etiology / Q000473:pathology*; D011648:Pulmonary Adenomatosis, Ovine / Q000209:etiology / Q000473:pathology*; D012756:Sheep; D014412:Tumor Virus Infections / Q000209:etiology / Q000473:pathology*
vernacular_title: Die sogenannte Lungenadenomatose des Schafes--eine aus vergleichend pathologischer Sicht interessante Pneumopathie.