title: The role of tumor necrosis factor and interleukin 1 in the immunoinflammatory response.
abstract: Monocytes and tissue macrophages produce at least two groups of protein mediators of inflammation, interleukin 1 (IL-1) and tumor necrosis factor (TNF). Recent studies have emphasized that TNF and IL-1 modulate the inflammatory function of endothelial cells, leukocytes, and fibroblasts. Although these cytokines share a number of biologic properties, they have quite distinct gene and protein structures. It is our purpose to focus on the role of these mediators in inflammation.
authors.affiliation: Department of Immunology, Cetus Corp, Palo Alto, California 94303.
authors.forename: J W
authors.initials: JW
authors.lastname: Larrick
authors.forename: S L
authors.initials: SL
authors.lastname: Kunkel
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000503:physiopathology; D007375:Interleukin-1 / Q000502:physiology*; D008969:Molecular Sequence Data; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
chemical_list: D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha