Benign monoclonal gammopathy presenting with severe renal failure.
A patient with monoclonal gammopathy and renal failure due to kappa light chain deposition in the glomerular basement membrane is reported. After 8 months, he developed a progressive and severe renal failure requiring haemodialysis. 30 months later, the monoclonal gammopathy was unchanged. Clinical features, as well as kinetic and immunological studies, were consistent with a diagnosis of benign monoclonal gammopathy (BMG). This case suggests that the renal failure complicating a monoclonal gammopathy is not related to its malignancy.
Gavarotti
P
P
Fortina
F
F
Costa
D
D
Verzetti
G
G
Redoglia
V
V
Boccadoro
M
M
D000328:Adult; D001485:Basement Membrane / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis / Q000652:urine; D007676:Kidney Failure, Chronic / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology; D007700:Kinetics; D008297:Male; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications*; D010950:Plasma Cells / Q000276:immunology
D007145:Immunoglobulin kappa-Chains