Malaria chemoprophylaxis with a proguanil-chloroquine-maloprim combination in Papua New Guinea.
Proguanil 200mg daily and chloroquine base 300mg weekly along with maloprim 1 tablet weekly was used as malaria chemoprophylaxis for 140 Hong Kong based soliders on a seven-week jungle exercise in a holoendemic malarial area of Papua New Guinea. On return from exercise all personnel were treated with primaquine 7.5mg three times daily for a two week period. One solider developed P. falciparum on the exercise whilst taking chemoprophylaxis and four subsequently developed P. vivax malaria after cessation of chemoprophylaxis.
Heap
B J
BJ
British Military Hospital, Hong Kong.
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage* / Q000652:urine; D002738:Chloroquine / Q000008:administration & dosage; D003622:Dapsone / Q000008:administration & dosage; D004338:Drug Combinations / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D008288:Malaria / Q000517:prevention & control* / Q000652:urine; D008889:Military Personnel; D010219:Papua New Guinea; D010963:Plasmodium falciparum; D010966:Plasmodium vivax; D002727:Proguanil / Q000008:administration & dosage / Q000652:urine; D011739:Pyrimethamine / Q000008:administration & dosage
D000962:Antimalarials; D004338:Drug Combinations; C001678:Maloprim; D002738:Chloroquine; D003622:Dapsone; D002727:Proguanil; D011739:Pyrimethamine