A case of lithium-chlorpromazine interaction.
A patient developed neurotoxicity after 2 years of treatment with a lithium-chlorpromazine combination. Symptoms consisted of confusion, extrapyramidal symptoms, and slow-wave EEG disturbances. The lithium ratio (red cell/plasma lithium) was consistently low. The possible mechanisms of this interaction are considered.
Yassa
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D001480:Basal Ganglia Diseases / Q000139:chemically induced; D002746:Chlorpromazine / Q000009:adverse effects* / Q000494:pharmacology; D003221:Confusion / Q000139:chemically induced; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000494:pharmacology; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced*
D016651:Lithium Carbonate; D008094:Lithium; D002746:Chlorpromazine