Diuresis-dependent excretions of low-molecular mass proteins in urine: beta 2-microglobulin, lysozyme, and ribonuclease.
An investigation was carried out into how the low-molecular mass proteins beta 2-microglobulin, lysozyme, and ribonuclease were excreted over 8 h after high fluid intake (22 ml/kg of body weight in 15 min). With increasing urine flow rate the amount of lysozyme excreted per hour or per millimole creatinine increased more markedly than that of beta 2-microglobulin while at the same time the excretion rate of ribonuclease decreased. The effect of urinary flow upon the excretion rates of the various low-molecular mass proteins has to be considered as a preanalytical factor when these proteins are used as indicators of tubular dysfunction.
Jung
K
K
Department of Experimental Organ Transplantation, University Hospital Charité, Humboldt University, Berlin, GDR.
Pergande
M
M
Porstmann
B
B
Porstmann
T
T
D000328:Adult; D004231:Diuresis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009113:Muramidase / Q000652:urine*; D012260:Ribonucleases / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine*
D001613:beta 2-Microglobulin; D012260:Ribonucleases; D009113:Muramidase