Antibacterial properties of 2-acetylpyridine-1-oxide thiosemicarbazones.
We have investigated the in vitro antibacterial activity of 13 2-acetylpyridine-1-oxide thiosemicarbazones and 5 thiosemicarbazides against 80 clinically significant bacterial cultures, including 13 isolates with known antibiotic resistance. Of the thiosemicarbazones tested, 5 had minimal inhibitory concentrations (MICs) of 0.25 microgram/ml for Neisseria gonorrhoeae isolates; 1 of these had an MIC range of 0.25-0.5 microgram/ml for the Neisseria meningitidis cultures, and 2 had MICs of 2 and 2-4 micrograms/ml for Staphylococcus aureus and Streptococcus faecalis isolates, respectively. Two of the thiosemicarbazides had MICs of 0.25 microgram/ml for N. gonorrhoeae, whereas 2 others had MICs of 2-4 and 4-8 micrograms/ml for S. aureus and S. faecalis isolates, respectively. The test compounds were ineffective against the gram-negative enteric cultures and the Pseudomonas isolates.
Dobek
A S
AS
Klayman
D L
DL
Scovill
J P
JP
Dickson
E T
ET
D001419:Bacteria / Q000187:drug effects*; D013293:Enterococcus faecalis / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D009345:Neisseria meningitidis / Q000187:drug effects; D011728:Pyridones / Q000494:pharmacology*; D012663:Semicarbazides / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013882:Thiosemicarbazones / Q000494:pharmacology*
D011728:Pyridones; D012663:Semicarbazides; D013882:Thiosemicarbazones; C005151:thiosemicarbazide