Possible involvement of nuclei in cadmium-induced modifications of cultured cells.
Reduced metaphase number and shortening of metaphase chromosomes were detected in McCoy cells exposed to 100 microM CdSO4 (maximal exposure time: 7 h). One hour exposure to 109Cd was enough to label the cell nucleus. This possibly suggests an early nuclear involvement in Cd-induced cell damage.
Fighetti
M A
MA
Institutes of Pharmacology, University of Sassari, Italy.
Miele
M
M
Montella
A
A
Desole
M S
MS
Congiu
A M
AM
Anania
V
V
D000818:Animals; D002104:Cadmium / Q000378:metabolism / Q000633:toxicity*; D002106:Cadmium Radioisotopes; D002467:Cell Nucleus / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D002478:Cells, Cultured; D002875:Chromosomes / Q000187:drug effects / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D051379:Mice
D002106:Cadmium Radioisotopes; D002104:Cadmium