title: Cyclosporin-associated microfibrils in cardiac transplant patients.
abstract: Endomyocardial biopsies from 21 cyclosporin-treated cardiac transplant patients were studied at the ultrastructural level. Eight patients exhibited focal interstitial accumulation of filaments, which most commonly measured 8-10 nm in diameter (range 7-16 nm). The filaments were straight, hollow, and nonbranching. Filament accumulation was observed as early as 4 days posttransplant. No filament accumulation was observed in 17 donor endomyocardial biopsies obtained at the time of transplantation. The ultrastructure of the filaments was similar to that of amyloid fibrils. Stains for amyloid at the light microscopic level were uniformly negative, however. Until the exact nature of the filaments is determined, we propose that they be referred to as cyclosporin associated microfibrils.
authors.affiliation: Department of Pathology, Cleveland Clinic Foundation, Ohio.
authors.forename: J L
authors.initials: JL
authors.lastname: Myles
authors.forename: N B
authors.initials: NB
authors.lastname: Ratliff
authors.forename: J T
authors.initials: JT
authors.lastname: McMahon
authors.forename: R R
authors.initials: RR
authors.lastname: Tubbs
authors.forename: L R
authors.initials: LR
authors.lastname: Golding
authors.forename: R E
authors.initials: RE
authors.lastname: Hobbs
authors.forename: G
authors.initials: G
authors.lastname: Rincon
authors.forename: R W
authors.initials: RW
authors.lastname: Sterba
authors.forename: R
authors.initials: R
authors.lastname: Stewart
mesh_terms: D008841:Actin Cytoskeleton / Q000187:drug effects* / Q000648:ultrastructure; D003524:Cyclosporins / Q000494:pharmacology / Q000627:therapeutic use*; D003599:Cytoskeleton / Q000187:drug effects*; D016027:Heart Transplantation; D006801:Humans; D009206:Myocardium / Q000648:ultrastructure
chemical_list: D003524:Cyclosporins