Wegener's granulomatosis and autoantibodies to neutrophil antigens.
We report five cases of Wegener's granulomatosis all of whom had clinical and histological evidence of disease activity at presentation and in whom autoantibodies to neutrophil antigens were detected. This test may prove useful for the diagnosis of this serious condition and help to monitor disease activity during treatment.
McCluskey
D R
DR
Maxwell
A P
AP
Watt
L
L
D000328:Adult; D000941:Antigens / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D011863:Radioimmunoassay
D000941:Antigens; D001323:Autoantibodies