title: Trial of ganglioside GM1 in acute stroke.
abstract: Ganglioside GM1 (100 mg) was given daily by intramuscular injection for 28 days in a double-blind placebo controlled trial of acute stroke. No significant difference was detected in a 6 month follow-up period between well matched control and active groups. Although the number of patients studied was small the findings are believed to indicate that GM1 is unlikely to be of value in the treatment of acute stroke in the dose and route of administration used.
authors.affiliation: Department of Medicine, Whittington Hospital, London, UK.
authors.forename: B I
authors.initials: BI
authors.lastname: Hoffbrand
authors.forename: P J
authors.initials: PJ
authors.lastname: Bingley
authors.forename: S M
authors.initials: SM
authors.lastname: Oppenheimer
authors.forename: C D
authors.initials: CD
authors.lastname: Sheldon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000628:therapy*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005677:G(M1) Ganglioside / Q000008:administration & dosage*; D006801:Humans; D007273:Injections, Intramuscular; D008875:Middle Aged; D011897:Random Allocation
chemical_list: D005677:G(M1) Ganglioside