Oncogenic response of strain A/J mice to inhaled chemicals.
Strain A/J mice were exposed by inhalation for 6 h/d, 5 d/wk, for 6 mo to carbon disulfide, 1,2-dibromoethane, ethylene oxide, naphthalene, nitrogen dioxide, or vinyl chloride. Significant increases in pulmonary adenoma formation were observed following exposure to 300 ppm carbon disulfide; 20 and 50 ppm 1,2-dibromoethane; 70 and 200 ppm ethylene oxide; 10 ppm nitrogen dioxide; and 50, 200, and 500 ppm vinyl chloride compared to control animals. Repeated studies with 1,2-dibromoethane, ethylene oxide, and vinyl chloride gave similarly significant results. Exposure of mice to 30 ppm naphthalene did not elicit a significant adenoma response. Histopathological examination of lungs from animals in these studies revealed multiple alveolar adenomas. Results from earlier studies with these chemicals, using strain A mice and Swiss mice, and bioassay information with rats and mice were compared with these data. These results provide further information for the validation of this in vivo model as a tool for predicting oncogenic potential following chemical exposure.
Adkins
B
B
Van Stee
E W
EW
Simmons
J E
JE
Eustis
S L
SL
D000236:Adenoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D002245:Carbon Dioxide / Q000633:toxicity; D002273:Carcinogens; D015946:Ethylene Dibromide / Q000633:toxicity; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D009281:Naphthalenes / Q000633:toxicity; D009585:Nitrogen Dioxide / Q000633:toxicity; D014752:Vinyl Chloride / Q000633:toxicity
D002273:Carcinogens; D009281:Naphthalenes; D002245:Carbon Dioxide; D015946:Ethylene Dibromide; C031721:naphthalene; D009585:Nitrogen Dioxide; D014752:Vinyl Chloride