Effect of synthetic prostaglandin E1 analog on gastric emptying of meals in man.
Forty-five subjects with healed duodenal ulcer were administered either a placebo or a low-dose or high-dose regimen of misoprostol, a synthetic PGE1 analog, in a double-blind, random, parallel-group design to assess the effect of this prostaglandin compound on the gastric emptying of liquid-solid meals. A dual-radionuclide technique to measure liquid- and solid-phase gastric emptying rates of physiological meals by external gamma camera imaging was used. All subjects had a pretreatment control (baseline) evaluation, followed one week later by a treatment-influenced emptying study. The results demonstrated that misoprostol did not significantly alter gastric emptying of either liquids or solids; however, these results cannot be extrapolated to other prostaglandin compounds because of the diverse and sometimes paradoxical effects of different prostaglandins on gastric motility.
Moore
J G
JG
Alazraki
N
N
Clay
G D
GD
D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001628:Beverages; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D005502:Food; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D007204:Indium; D008297:Male; D008875:Middle Aged; D016595:Misoprostol; D011868:Radioisotopes; D011877:Radionuclide Imaging; D011897:Random Allocation; D013671:Technetium Tc 99m Sulfur Colloid
D000897:Anti-Ulcer Agents; D011868:Radioisotopes; D007204:Indium; D016595:Misoprostol; D013671:Technetium Tc 99m Sulfur Colloid; D000527:Alprostadil