title: [Successful antibiotic treatment of a pulmonary infection with Nocardia asteroides (biovariety A3)].
abstract: An open lung biopsy in a 67-year-old man revealed nocardiosis as the cause of a treatment-resistant pulmonary infection. His resistance had been weakened by a non-Hodgkin lymphoma, polychemotherapy and long-term steroid medication. The nocardiosis was cured by a 26-day high-dosage regimen of imipenem and amikacin in combination. A six-month period of co-trimoxazole followed to ensure treatment success. Nocardia asteroides (biovariety A3) was found to be the causative organism, the second time that this has been described as cause of a human infection.
authors.affiliation: Abteilung Allgemeine Innere Medizin, Katharinenhospital der Stadt Stuttgart.
authors.forename: S
authors.initials: S
authors.lastname: Ruppert
authors.forename: H M
authors.initials: HM
authors.lastname: Reinold
authors.forename: P
authors.initials: P
authors.lastname: Jipp
authors.forename: G
authors.initials: G
authors.lastname: Schröter
authors.forename: E
authors.initials: E
authors.lastname: Egner
authors.forename: K P
authors.initials: KP
authors.lastname: Schaal
mesh_terms: D000368:Aged; D000583:Amikacin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004338:Drug Combinations / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage; D008171:Lung Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000188:drug therapy; D008297:Male; D009617:Nocardia Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D009616:Nocardia asteroides / Q000302:isolation & purification; D009894:Opportunistic Infections / Q000188:drug therapy / Q000209:etiology; D013420:Sulfamethoxazole / Q000008:administration & dosage; D014295:Trimethoprim / Q000008:administration & dosage; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D015378:Imipenem; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D000583:Amikacin; D014295:Trimethoprim; D013420:Sulfamethoxazole
vernacular_title: Erfolgreiche antibiotische Behandlung einer pulmonalen Infektion mit Nocardia asteroides (Biovarietät A3).