title: Effective and safe therapy with coenzyme Q10 for cardiomyopathy.
abstract: Coenzyme Q10 (CoQ10) is indispensable in mitochondrial bioenergetics and for human life to exist. 88/115 patients completed a trial of therapy with CoQ10 for cardiomyopathy. Patients were selected on the basis of clinical criteria, X-rays, electrocardiograms, echocardiography, and coronary angiography. Responses were monitored by ejection fractions, cardiac output, and improvements in functional classifications (NYHA). Of the 88 patients 75%-85% showed statistically significant increases in two monitored cardiac parameters. Patients with the lowest ejection fractions (approx. 10%-30%) showed the highest increases (115 delta %-210 delta %) and those with higher ejection fractions (50%-80%) showed increases of approx. 10 delta %-25 delta % on therapy. By functional classification, 17/21 in class IV, 52/62 in class III, and 4/5 in class II improved to lower classes. Clinical responses appeared over variable times, and are presumably based on mechanisms of DNA-RNA-protein synthesis of apoenzymes which restore levels of CoQ10 enzymes in a deficiency state. 10/21 (48%) of patients in class IV, 26/62 (42%) in class III, and 2/5 (40%) in class II had exceptionally low control blood levels of CoQ10. Clinical responses on therapy with CoQ10 appear maximal with blood levels of approx. 2.5 micrograms CoQ10/ml and higher during therapy.
authors.affiliation: Department of Medicine, Scott and White Clinic, Temple, Texas.
authors.forename: P H
authors.initials: PH
authors.lastname: Langsjoen
authors.forename: K
authors.initials: K
authors.lastname: Folkers
authors.forename: K
authors.initials: K
authors.lastname: Lyson
authors.forename: K
authors.initials: K
authors.lastname: Muratsu
authors.forename: T
authors.initials: T
authors.lastname: Lyson
authors.forename: P
authors.initials: P
authors.lastname: Langsjoen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002302:Cardiac Output / Q000187:drug effects*; D009202:Cardiomyopathies / Q000188:drug therapy*; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy; D002986:Clinical Trials as Topic; D003067:Coenzymes; D003327:Coronary Disease / Q000188:drug therapy; D005260:Female; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume / Q000187:drug effects; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10