title: Adeturone protection of hemopoiesis in lethally irradiated mice and rats.
abstract: Experiments were carried out to investigate the possibility of providing chemical protection to blood forming organs and increasing animal survival rates in lethally irradiated H mice and Wistar rats. A 300 mg/kg dose of the radioprotective agent was injected intraperitoneally 15-30 min prior to irradiation with 8.0 Gy gamma rays. Recorded were 30-day survival rates and the state of hemopoiesis on days 3 and 10 postradiation as judged by spleen weight and total counts of spleno- and myelokaryocytes. At 8.0 Gy exposure was observed to cause severe spleen and bone-marrow hypoplasia on day 3 postradiation. Adeturone pretreatment provided slight protection to rat spleen and mouse bone marrow; by day 10, however, both animal species exhibited a vigorous proliferative response of nucleated cells in the bone marrow, which resulted in 75% survival rate among animals exposed to a lethal radiation dose.
authors.affiliation: Institute of Röentgenology and Radiobiology, Medical Academy, Sofia, Bulgaria.
authors.forename: M I
authors.initials: MI
authors.lastname: Minkova
authors.forename: T P
authors.initials: TP
authors.lastname: Pantev
mesh_terms: D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000528:radiation effects; D001854:Bone Marrow Cells; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects*; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000166:cytology; D013997:Time Factors; D014916:Whole-Body Irradiation; D000338:beta-Aminoethyl Isothiourea / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; C012704:Adeturon; D000255:Adenosine Triphosphate