Prostacyclin production in vascular endothelium of patients with Blackfoot disease.
The levels of 6-keto-PGF1 alpha and TXB2 were determined by the RIA method in Blackfoot disease which is an endemic disease of the peripheral vascular system found in the southwest coast of Taiwan. The level of TXB2 was normal, but that of 6-keto-PGF2 alpha concentration was 30% lower than the normal. The activity of 15-hydroxyprostaglandin dehydrogenase was higher in patients' blood plasma than in the normal. Patient's vascular endothelium was also found to have lower prostacyclin synthase activity. These results suggest that the reduced prostacyclin production in vascular endothelium contributes to the pathogenesis of Blackfoot disease.
Mak
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Department of Biology, National Cheng Kung University, Tainan, Taiwan, Republic of China.
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D001158:Arteries / Q000201:enzymology; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D004730:Endothelium, Vascular / Q000378:metabolism*; D011464:Epoprostenol / Q000096:biosynthesis*; D006801:Humans; D006911:Hydroxyprostaglandin Dehydrogenases / Q000097:blood; D019746:Intramolecular Oxidoreductases; D007535:Isomerases / Q000032:analysis; D011450:Prostaglandin Endoperoxides, Synthetic / Q000378:metabolism; D044262:Prostaglandin H2; D011463:Prostaglandins H / Q000378:metabolism; D013929:Thromboxane B2 / Q000097:blood; D014652:Vascular Diseases / Q000378:metabolism*
D011450:Prostaglandin Endoperoxides, Synthetic; D011463:Prostaglandins H; D044262:Prostaglandin H2; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D003577:Cytochrome P-450 Enzyme System; D011464:Epoprostenol; D006911:Hydroxyprostaglandin Dehydrogenases; D007535:Isomerases; D019746:Intramolecular Oxidoreductases; C022461:prostacyclin synthetase