[Long-term efficacy of high-dose aerosol corticotherapy in the treatment of severe asthma].
Forty-five patients with severe, poorly controlled asthma, including 23 corticosteroid-dependent patients, were treated with a preparation of beclomethasone dipropionate aerosol delivering 250 mcg per puff. The daily dose ranged from 1000 to 2000 mcg. The mean follow-up period was 14 +/- 7 months, and 11 patients have now been followed up for more than 2 years. Forty-two patients were improved, and total withdrawal of continuous steroid therapy could be achieved in 13 cases. Treatment remained effective in long term use, provided a minimum of 1000 mcg/day was given. However, despite clinical improvement the obstructive syndrome persisted in 65% of the patients.
Dietemann-Molard
A
A
Service de Pneumologie II, Pavillon Laennec, CHRU de Strasbourg.
Tenabene
A
A
Kapps
M
M
Pauli
G
G
D000280:Administration, Inhalation; D000336:Aerosols; D001249:Asthma / Q000188:drug therapy*; D001507:Beclomethasone / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000336:Aerosols; D001507:Beclomethasone
Efficacité au long cours d'une corticothérapie en aérosol fortement dosé dans le traitement de l'asthme sévère.