Mitomycin C plasma levels after intravesical instillation with and without hyaluronidase.
In 20 patients undergoing transurethral resection for bladder tumor or multiple transurethral biopsies for monitoring after transurethral resection, mitomycin C, 20 mg., was instilled into the bladder immediately after the procedure. Mitomycin C was associated with hyaluronidase, 200.000 U, in 10 patients. Serum levels of mitomycin were determined by column chromatography 30 and 60 minutes after instillation. Hyaluronidase was not found to make any difference in mitomycin absorption. Potential expansions of the therapeutic modalities for preventing recurrent bladder tumor by hyaluronidase are discussed.
Maier
U
U
Baumgartner
G
G
D003131:Combined Modality Therapy; D004338:Drug Combinations; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage / Q000627:therapeutic use*; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D011182:Postoperative Care; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000601:surgery
D004338:Drug Combinations; D008937:Mitomycins; D016685:Mitomycin; D006821:Hyaluronoglucosaminidase