title: Effect of interleukin-2 and mitogen on in vitro immunoglobulin production by peripheral blood lymphocytes from patients with selective IgM deficiency.
abstract: Immunoglobulin production by mitogen and recombinant interleukin-2-(rIL-2)-stimulated lymphocytes from IgM-deficient patients was studied. The findings were that subnormal serum IgM levels did not necessarily predict defective in vitro IgG or IgM production, lymphocytes from some IgM-deficient patients exhibited defective T cell function, and rIL-2 did not enhance defective in vitro immunoglobulin production.
authors.affiliation: Department of Pediatrics, Medical College of GA, Augusta 30912.
authors.forename: J E
authors.initials: JE
authors.lastname: Moffitt
authors.forename: M F
authors.initials: MF
authors.lastname: Guill
authors.forename: B B
authors.initials: BB
authors.lastname: Wray
authors.forename: D A
authors.initials: DA
authors.lastname: Brown
authors.forename: N W
authors.initials: NW
authors.lastname: Peacocke
authors.forename: E W
authors.initials: EW
authors.lastname: Ades
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D002675:Child, Preschool; D004406:Dysgammaglobulinemia / Q000097:blood*; D006801:Humans; D007075:Immunoglobulin M / Q000172:deficiency*; D007136:Immunoglobulins / Q000096:biosynthesis*; D007158:Immunologic Techniques; D007223:Infant; D007376:Interleukin-2 / Q000494:pharmacology*; D008214:Lymphocytes / Q000378:metabolism*; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology*
chemical_list: D007075:Immunoglobulin M; D007136:Immunoglobulins; D007376:Interleukin-2; D008934:Mitogens