title: [Alcohol and the cardiovascular system].
abstract: Because of the high frequency of cardiovascular diseases and a steadily increasing consumption of alcohol the potentially causal relationship between alcohol and cardiovascular diseases gains great interest for public health policy. Alcohol and its metabolites induce a toxic damage of myocardial metabolism with an injury of electromechanic coupling. As a consequence of acute alcoholic intake cardiac arrhythmias and a reduced contractility of the myocardium are found not only for chronic alcoholics but also in healthy non-drinkers. Chronic abuse of alcoholic beverages for many years can be the cause of alcoholic cardiomyopathy in a small percentage of patients, who have a bad prognosis. Atria and ventricles are dilated, light and electron microscopic changes of the myocardium are unspecific. The pathogenesis of alcoholic cardiomyopathy is unknown, modulations of cardiomyocytic membranes are discussed in the course of a toxic damage. In the genesis of atherosclerosis alcohol can approach from different sites: Changings on thrombocytes and an increase of HDL-cholesterin can be protective, however an increase in blood pressure support the process of atherosclerosis. In numerous investigations a smaller degree of atherosclerosis was found for little or moderate alcohol intake, while in chronic heavy abuse of alcohol a higher extent of atherosclerosis was observed. As the amount of alcohol, assumed to be protective against the development of atherosclerosis, is consumed already by the majority of the population, there is no reason to propagate a regulate consume of moderate amount of alcoholic beverages.
authors.affiliation: Pathologisches Institut, Universität Düsseldorf.
authors.forename: H
authors.initials: H
authors.lastname: Frenzel
authors.forename: H
authors.initials: H
authors.lastname: Roth
authors.forename: B
authors.initials: B
authors.lastname: Schwartzkopff
mesh_terms: D000437:Alcoholism / Q000150:complications*; D001161:Arteriosclerosis / Q000473:pathology*; D002310:Cardiomyopathy, Alcoholic / Q000473:pathology*; D003327:Coronary Disease / Q000473:pathology; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D009206:Myocardium / Q000473:pathology
chemical_list: D008074:Lipoproteins
vernacular_title: Alkohol und Herz-/Kreislaufsystem.