Preservation and loss of spatial memory in aged rats and humans: implications for the analysis of memory dysfunction in dementia.
Research with laboratory rats and humans demonstrating that the usual age-related deficits in spatial working memory can be attenuated or eliminated by prior training earlier in adult life is reviewed and possible mechanisms for this phenomenon are considered. A new technique for measuring remote memory for spatial information in humans is described and preliminary results with demented patients are discussed.
Beatty
W W
WW
Department of Psychology, North Dakota State University, Fargo 58105.
D000375:Aging / Q000502:physiology*; D000818:Animals; D003704:Dementia / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D008569:Memory Disorders / Q000503:physiopathology*; D051381:Rats; D013037:Spatial Behavior / Q000502:physiology*