Kinetics of disposition of xenobiotics and their metabolites.
The principles of pharmacokinetics, which have evolved over the last quarter of a century and are now regarded as a major tool in quantifying and rationalizing drug action, are outlined. These are presented within a broad context to allow application to all xenobiotics and hence, to aid toxicological as well as pharmacological investigations. The trend away from descriptive models towards biologically based systems allowing mechanistic interpretation is stressed. In particular the development of kinetic approaches to characterise the formation and disposition of metabolites is described.
Houston
J B
JB
Department of Pharmacy, University of Manchester, England, U.K.
D000042:Absorption; D000818:Animals; D001682:Biological Availability; D006207:Half-Life; D006801:Humans; D008658:Inactivation, Metabolic; D008657:Metabolic Clearance Rate; D015262:Xenobiotics / Q000493:pharmacokinetics*
D015262:Xenobiotics