title: Role of platelet-activating factor-acether in mediating guinea pig anaphylaxis.
abstract: The pathophysiology of anaphylaxis is very complex, and the sequelae of events are not fully explained in terms of the effects of histamine and peptide leukotrienes alone. Platelet-activating factor (1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, PAF-acether) has been detected in animals undergoing anaphylaxis. Injection of synthetic PAF-acether induces similar effects, including bronchoconstriction, respiratory arrest, systemic hypotension, neutropenia, and thrombocytopenia. The results reported here demonstrate that the histamine- and leukotriene-independent component of guinea pig anaphylaxis in vivo and in isolated lung parenchymal strips in vitro is mediated by PAF-acether. However, PAF-acether is not responsible for the anaphylaxis-induced thrombocytopenia.
authors.forename: H
authors.initials: H
authors.lastname: Darius
authors.forename: D J
authors.initials: DJ
authors.lastname: Lefer
authors.forename: J B
authors.initials: JB
authors.lastname: Smith
authors.forename: A M
authors.initials: AM
authors.lastname: Lefer
mesh_terms: D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D000525:Alprazolam; D000707:Anaphylaxis; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology; D001794:Blood Pressure; D004155:Diphenhydramine / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007700:Kinetics; D008168:Lung / Q000187:drug effects / Q000276:immunology*; D008297:Male; D010047:Ovalbumin; D010972:Platelet Activating Factor / Q000276:immunology*; D010976:Platelet Count / Q000187:drug effects; D011720:Pyrazoles / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D010972:Platelet Activating Factor; D011720:Pyrazoles; D001569:Benzodiazepines; D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D004155:Diphenhydramine; D010047:Ovalbumin; D000525:Alprazolam