Anti-mutagenicity of catechin against environmental mutagens.
Catechu is the non-mutagenic component of betel quid. We have tested catechu extract and catechin for anti-mutagenic activity in Salmonella typhimurium strain TA98 against environmental mutagens relevant to India. Catechu extract, as well as catechin, shows a dose-dependent decrease in the mutagenicity of tobacco and masheri extracts, and bidi and cigarette smoke condensates in TA98 with S9 mix. Mutagenicity of extracts of charred and non-charred meat in TA98 is also inhibited by catechu extract and catechin in a dose-dependent manner with or without S9 mix.
Nagabhushan
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Carcinogenesis Division, Tata Memorial Centre, Parel, Bombay, India.
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D000818:Animals; D002392:Catechin / Q000494:pharmacology*; D005511:Food Handling; D006358:Hot Temperature; D008460:Meat; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D010947:Plants, Toxic; D012486:Salmonella typhimurium / Q000187:drug effects; D014026:Nicotiana
D009153:Mutagens; D010936:Plant Extracts; D002392:Catechin