title: [2-stage microsurgical autoneuroplasty under pharmacologic effects (experimental research)].
abstract: It is shown in experiments on 36 dogs that two-stage microsurgical autoneuroplasty with subsequent administration of an inhibitor of proteolytic enzymes (aminocaproic acid), an antioxidant (tocopherol acetate) and heparin makes it possible to realize more fully the histoblastic potencies of tissues which are components of the injured nerve and the graft. This circumstance leads to the improvement of the morphofunctional results of sciatic nerve restoration after its experimental injury.
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Chaĭkovskiĭ
mesh_terms: D000614:Aminocaproates / Q000627:therapeutic use*; D015119:Aminocaproic Acid / Q000627:therapeutic use*; D000818:Animals; D003131:Combined Modality Therapy; D003238:Connective Tissue / Q000187:drug effects; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006493:Heparin / Q000627:therapeutic use*; D008866:Microsurgery / Q000379:methods*; D009416:Nerve Regeneration / Q000187:drug effects; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000187:drug effects / Q000601:surgery*; D013536:Suture Techniques; D013997:Time Factors; D024505:Tocopherols; D014182:Transplantation, Autologous; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
chemical_list: D000614:Aminocaproates; D014810:Vitamin E; D006493:Heparin; D024502:alpha-Tocopherol; D024505:Tocopherols; D015119:Aminocaproic Acid
vernacular_title: Dvukhétapnaia mikrokhirurgicheskaia autoneĭroplastika v usloviiakh farmakologicheskogo vozdeĭstviia (éksperimental'noe issledovanie).