title: A randomized study of cyclosporine with and without prednisone in renal allograft recipients. Canadian Transplant Group.
abstract: Sixty-nine patients receiving Cs after cadaveric or LRD renal transplants were randomly allocated to receive prednisone or no prednisone beginning on the day of transplant. There were 36 in the prednisone group and 33 in the group assigned to no prednisone. Of these latter, only seven (21%) never received prednisone and an additional four had one short course for rejection episodes (11%). Of the remaining 22 who were placed on continuous steroids, only 12 met rejection criteria and either some or all of the remainder probably had Cs nephrotoxicity. The patient and graft survival were better but not statistically so in the no-prednisone group (97% v 89%) and (88% v 78%), and the number of infections was only half that of the prednisone-treated group (22% v 42%). A policy of withholding steroids except for rejection episodes does not prejudice graft or patient survival in Cs-treated patients.
authors.affiliation: Ambulatory Care Centre, Victoria General Hospital Halifax, Nova Scotia, Canada.
authors.forename: A S
authors.initials: AS
authors.lastname: MacDonald
authors.forename: P
authors.initials: P
authors.lastname: Daloze
authors.forename: R
authors.initials: R
authors.lastname: Dandavino
authors.forename: S
authors.initials: S
authors.lastname: Jindal
authors.forename: L
authors.initials: L
authors.lastname: Bear
authors.forename: J B
authors.initials: JB
authors.lastname: Dossetor
authors.forename: J
authors.initials: J
authors.lastname: Klassen
authors.forename: C R
authors.initials: CR
authors.lastname: Stiller
authors.forename: B
authors.initials: B
authors.lastname: Lockwood
authors.forename: C E
authors.initials: CE
authors.lastname: Reeve
mesh_terms: D003524:Cyclosporins / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D011241:Prednisone / Q000627:therapeutic use*; D014184:Transplantation, Homologous
chemical_list: D003524:Cyclosporins; D011241:Prednisone