[Agglutination of intravenous lipid emulsions by acute phase proteins of inflammation].
Agglutination of intravenous fat emulsions (IVFE) by sera of acutely ill children was studied in vitro in 23 patients. C-Reactive protein (CRP) has been showed to agglutinate with IVFE; after discarding CRP, serum of acutely ill patients still agglutinate with IVFE. The agglutination score in generalized sepsis is significantly highest than in localized sepsis. We studied agglutination during three periods: first days of treatment by antibiotics (period 1), between the fourth day and the end of treatment (period 2), and after the end of treatment (period 3). In period 2, when orosomucoid concentrations; nevertheless, the observation of an agglutination in periods 1 and 3 where the mean orosomucoid level is within normal range, strongly suggests that one or more others acute phase proteins are also involved in occurrence of agglutination.
Gobert
E
E
Laboratoire de Biochimie, Hôpital Bretonneau, Paris, France.
Hartmann
J F
JF
Bougle
D
D
Demelier
J F
JF
Beaufils
F
F
D000371:Agglutination; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D001798:Blood Proteins / Q000032:analysis; D002097:C-Reactive Protein / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D005217:Fat Emulsions, Intravenous / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009961:Orosomucoid / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001798:Blood Proteins; D005217:Fat Emulsions, Intravenous; D009961:Orosomucoid; D002097:C-Reactive Protein
Agglutination des émulsions lipidiques intraveineuses par les protéines de la phase aiguë de l'inflammation.