[Are glomerular hyperfiltration and hyperperfusion involved in the development and progression of nephropathies?].
In the present paper the significance of non-immunological factors in the development and progression of nephropathies according to the hypothesis of Brenner et al. especially hemodynamic changes in the glomerula with glomerular hyperperfusion and/or hyperfiltration is discussed and therapeutic conclusions are made. The normalized glomerular pressure conditions (converting-enzyme inhibitors), a normalization of hyperglycemia in diabetics, a retention in the use of protein-rich diet and platelet-aggregation inhibitors, respectively, play a special part in the treatment of chronic nephropathies.
Kokot
F
F
Nephrologische Klinik der Schlesischen Medizinischen Akademie in Katowice.
Kuska
J
J
D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000503:physiopathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply*; D012039:Regional Blood Flow; D012079:Renal Circulation
Sind glomeruläre Hyperfiltration und Hyperperfusion an der Entstehung und Progression von Nephropathien beteiligt?