[Study of the comparative anti-arrhythmic effectiveness of allapinin, ethacizine and mexitil in patients with ventricular disorders of cardiac rhythm].
A double blind randomized cross-over study was conducted to analyze antiarrhythmic activity of the new Soviet drugs allapinin , ethacizine in comparison with mexitil. Altogether 33 patients with ventricular disorders of cardiac rhythm of high gradations after Lown B. were investigated including patients with paroxysmal ventricular tachycardia. The authors managed to establish and compare the group antiarrhythmic efficacy and safety of each drug, and to assess a degree of selective efficacy of each of them.
Smetnev
A S
AS
Golitsyn
S P
SP
Levin
E R
ER
Sokolov
S F
SF
Koltunova
M I
MI
D000157:Aconitine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D031841:Aconitum / Q000031:analogs & derivatives*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008801:Mexiletine / Q000627:therapeutic use*; D008875:Middle Aged; D010640:Phenothiazines / Q000627:therapeutic use*; D011897:Random Allocation; D013613:Tachycardia, Ectopic Junctional / Q000188:drug therapy*; D013614:Tachycardia, Paroxysmal / Q000188:drug therapy*; D013617:Tachycardia, Supraventricular / Q000188:drug therapy*
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; D008801:Mexiletine; C051402:allapinin; C046818:ethacizine; D000157:Aconitine
Izuchenie sravnitel'noĭ antiaritmicheskoĭ éffektivnosti allapinina, étatsizina i meksitila u bol'nykh s zheludochkovymi narusheniiami ritma serdtsa.