title: Impact of reinduction regimens on the clinical course of adult acute nonlymphocytic leukemia.
abstract: All clinical studies in the English literature from 1976 to mid-1987 that address drug management of refractory or relapsed ANLL are reviewed and summarized. We conclude that, although many regimens may induce a CR, none is clearly superior. New drugs and or drug combinations must be sought if treatment outcomes are to be substantially improved. At present it appears that combination chemotherapy with VP-16 has not been extensively studied and may be active in non-cross-resistant regimens.
authors.affiliation: Department of Internal Medicine, University of California, Sacramento 95817.
authors.forename: J L
authors.initials: JL
authors.lastname: Welborn
authors.forename: J P
authors.initials: JP
authors.lastname: Lewis
authors.forename: F J
authors.initials: FJ
authors.lastname: Meyers
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D012074:Remission Induction