Historical aspects and applications of barbituric acid derivatives. A review.
This review considers the pharmacological and other applications of barbituric and 2-thiobarbituric acid derivatives. A chronological description about the discovery, structural studies and first clinical assays are given. Therapeutic expectations as anticonvulsant, antimicrobial, spasmolytic, antiinflammatory, antitumoral and some other effects of 5,5-disubstituted barbituric acids and alkylidene- or arylidenebarbituric acids are overviewed. A considerable amount of these types of compounds have been proposed as industrial dyes and pigments, photosensitizers and thermosensitive materials.
Guillén Sans
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R
Department of Nutrition and Food Science, Faculty of Pharmacy, University of Sevilla, Spain.
Guzmán Chozas
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M
D000818:Animals; D001463:Barbiturates / Q000266:history* / Q000494:pharmacology; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans
D001463:Barbiturates