Short term and direct influence of oestradiol on glucagon secretion stimulated by arginine.
Long-term oestrogen treatments disturb the endocrine pancreas, with associated hypoglucagonaemia and hyperinsulinism. Short-term influences of oestradiol (4 h-8 h) were tested in vivo, and direct effects were studied in vitro with pieces of pancreas or islets of Langerhans. Both models showed a direct and dose-dependent inhibitory effect of oestradiol on the arginine-stimulated secretion of glucagon, related to the short-term hypoglucagonaemia. However, this direct negative effect of oestradiol on A cells occurred in spite of any influence, either on insulinaemia or on the arginine-induced insulin secretion. This supports the hypothesis of a possibility of A cells to function independently of B cells.
Faure
A
A
Laboratoire d'Endocrinologie, Université de Bordeaux I, Talence, France.
Haouari
M
M
Sutter
B C
BC
D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D004357:Drug Synergism; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005934:Glucagon / Q000378:metabolism*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D010052:Ovariectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D007328:Insulin; D004958:Estradiol; D005934:Glucagon; D001120:Arginine