title: Controversial topics in kernicterus.
abstract: The physiology of the blood-brain barrier and its disruption by a variety of pathophysiologic processes in the development of experimental and clinical kernicterus are reviewed. The use of currently available methods for measuring free and bound bilirubin in developing strategies for the prevention of kernicterus and more subtle sequelae of hyperbilirubinemia also are presented.
authors.affiliation: Division of Neonatology, Children's Hospital of Philadelphia, Pennsylvania.
authors.forename: P
authors.initials: P
authors.lastname: Roth
authors.forename: R A
authors.initials: RA
authors.lastname: Polin
mesh_terms: D001663:Bilirubin / Q000097:blood; D001812:Blood-Brain Barrier; D001921:Brain / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D007647:Kernicterus / Q000503:physiopathology* / Q000517:prevention & control; D012307:Risk Factors
chemical_list: D001663:Bilirubin