[Inhibition of repair activity induced by gamma-, UV-irradiation and radiomimetics in cultured cells from schizophrenia patients].
A study was made of the processes of repair, virus reactivation, and formation of sister chromatid exchanges (SCE) in blood cells of patients with schizophrenia after the effect of gamma-radiation and 4-nitroquinoline-1-oxide. These processes were estimated by 12 criteria. The mutagen-induced disturbances in the processes of repair and SCE formation were found in cells of patients with schizophrenia and were absent in the control cells of healthy donors.
Zasukhina
G D
GD
Zharikov
N M
NM
L'vova
G N
GN
Vasil'eva
I M
IM
Chekova
V V
VV
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D004260:DNA Repair / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000528:radiation effects; D011831:Radiation Genetics; D012559:Schizophrenia / Q000097:blood / Q000235:genetics*; D012854:Sister Chromatid Exchange; D014466:Ultraviolet Rays; D014775:Virus Activation / Q000528:radiation effects
D015112:4-Nitroquinoline-1-oxide
Ingibirovanie reparativnoĭ aktivnosti, indutsirovannoĭ gamma-, UV-oblucheniem i radiomimetikami, v kul'tiviruemykh kletkakh bol'nykh shizofrenieĭ.