title: FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics.
abstract: A PAF antagonist, designated as FR-900452, was isolated from fermentation products of Streptomyces phaeofaciens and the molecular formula was determined as C22H25N3O3S. The compound inhibited PAF-induced rabbit platelet aggregation with an IC50 of 3.7 X 10(-7)M, but was much less active against collagen-, arachidonic acid- or ADP-induced aggregation (IC50; 6.4 X 10(-5), greater than 10(-4) or greater than 10(-4)M, respectively).
authors.forename: M
authors.initials: M
authors.lastname: Okamoto
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Nishikawa
authors.forename: T
authors.initials: T
authors.lastname: Ando
authors.forename: M
authors.initials: M
authors.lastname: Iwami
authors.forename: M
authors.initials: M
authors.lastname: Kohsaka
authors.forename: H
authors.initials: H
authors.lastname: Aoki
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003094:Collagen / Q000494:pharmacology; D005285:Fermentation; D007211:Indoles; D010879:Piperazines; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors* / Q000302:isolation & purification / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
chemical_list: D001095:Arachidonic Acids; D007211:Indoles; D010879:Piperazines; D010972:Platelet Activating Factor; C048269:FR 900452; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate; D003094:Collagen