[Protein restriction and metabolism of xenobiotics].
Young male rats were fed a balanced diet or a low-protein diet (casein 6%; w/w) for 6 weeks. After 2 weeks, each group was divided, one half being maintained as the control and the other half being fed diet-containing (Phenoclor DP6) at a level of 50 mg/kg for 4 weeks. A low-protein diet lowered the liver glutathione content and the activity of the mono-oxygenases. It lowered the inductive effect of PCB towards P450, NADPH-cytochrome c reductase, aminopyrine demethylase and aniline hydroxylase, but it raised the benzo(a) pyrene hydroxylase induction.
Albrecht
R
R
Pelissier
M A
MA
Miladi
N
N
Atteba
S
S
Desfontaines
C
C
Narbonne
J F
JF
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D001579:Benzopyrene Hydroxylase / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004044:Dietary Proteins / Q000378:metabolism*; D002149:Energy Intake; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000033:anatomy & histology; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D009929:Organ Size; D011078:Polychlorinated Biphenyls / Q000378:metabolism; D051381:Rats
D004044:Dietary Proteins; D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls; D006899:Mixed Function Oxygenases; D000815:Aniline Hydroxylase; D001579:Benzopyrene Hydroxylase; D000633:Aminopyrine N-Demethylase; D009251:NADPH-Ferrihemoprotein Reductase; D005978:Glutathione
Restriction protéique et métabolisme des xénobiotiques.