Synthesis and evaluation of LY121019, a member of a series of semisynthetic analogues of the antifungal lipopeptide echinocandin B.
Debono
M
M
Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285.
Abbott
B J
BJ
Turner
J R
JR
Howard
L C
LC
Gordee
R S
RS
Hunt
A S
AS
Barnhart
M
M
Molloy
R M
RM
Willard
K E
KE
Fukuda
D
D
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents / Q000138:chemical synthesis*; D002176:Candida albicans / Q000187:drug effects; D015195:Drug Design; D054714:Echinocandins; D005656:Fungal Proteins; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology; D010456:Peptides, Cyclic; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins; D010455:Peptides; D010456:Peptides, Cyclic; C042101:cilofungin; C007572:echinocandin B