Evaluation of the effect of topical steroids on human scar contracture using a nude mouse model.
Adult nude mice had 1.5 to 1.0 meshed split-thickness human skin applied to an excised area of their back. The animals were then randomized into two groups, one of which had a steroid cream applied to their graft on alternate days. The other group had no ointment applied and served as a control. The wounds were measured on a weekly basis and the rate of wound contracture was found to be identical. Topical steroids would thus appear to offer no benefit in the prevention of scar contracture.
Waymack
J P
JP
Shriners Burns Institute, Cincinnati Unit.
Robb
E
E
Plessinger
R
R
Warden
G D
GD
Alexander
J W
JW
D000818:Animals; D002921:Cicatrix / Q000188:drug therapy*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D016038:Skin Transplantation; D014183:Transplantation, Heterologous; D014222:Triamcinolone Acetonide / Q000627:therapeutic use*
D014222:Triamcinolone Acetonide