Clonal T-cell populations in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma.
Ten cases of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) and AILD-like lymphoma were studied by immunophenotypic and immunogenotypic analysis. All specimens were found to have a predominance of T cells by immunophenotypic analysis. DNA hybridization analyses showed three of five specimens of AILD and five of six specimens of AILD-like lymphoma to contain clonal rearrangements of the beta T-cell receptor gene. No rearrangements of the heavy or light chain immunoglobulin genes were seen in any case. A single case showed a progression of AILD with a germ-line pattern of beta T-cell receptor DNA to AILD-like lymphoma with detectable clonal rearrangements for beta T-cell receptor DNA. These results suggest that many, but not all, cases diagnosed histologically as AILD or AILD-like lymphoma contain a clonal proliferation of T-lymphocytes.
Weiss
L M
LM
Strickler
J G
JG
Dorfman
R F
RF
Horning
S J
SJ
Warnke
R A
RA
Sklar
J
J
D000368:Aged; D001706:Biopsy; D002999:Clone Cells; D005260:Female; D005802:Genes, MHC Class II; D005821:Genetic Techniques; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000235:genetics / Q000473:pathology*; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013154:Spleen / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology*
D011948:Receptors, Antigen, T-Cell