[Cells from homocystinuria patients--a model for the study of the repair mechanisms in human cells].
Repair processes in blood lymphocytes of children with hereditary homocystinuria have been studied. The identical results on the defective repair processes of damaged DNA were received by the two methods used. The method of vaccinia virus reactivation registered total disturbance of the repair function in cells, while the method of alkaline elution revealed the defects in the enzymes providing resynthesis of DNA breaks in normal conditions.
Zasukhina
G D
GD
Barashnev
Iu I
IuI
L'vova
G N
GN
Sinel'shchikova
T A
TA
Shoniia
N N
NN
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D002478:Cells, Cultured; D002648:Child; D003584:Cytological Techniques; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D006712:Homocystinuria / Q000097:blood*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D009154:Mutation; D014616:Vaccinia virus / Q000187:drug effects / Q000528:radiation effects
D015112:4-Nitroquinoline-1-oxide
Kletki bol'nykh gomotsistinurieĭ--model' dlia izucheniia mekhanizmov reparatsii v kletkakh cheloveka.