Use of an IgA-depleted intravenous immunoglobulin in a patient with an anti-IgA antibody.
In this report we describe the use of an IgA-depleted preparation of intravenous gamma-globulin in a patient with hypogammaglobulinemia and an anti-IgA antibody. An IgA containing intravenous gamma-globulin had previously produced anaphylactoid reactions, immune complex formation, and complement activation. The patient has had no reactions to the IgA-depleted preparation after 18 months of treatment; immune complex formation and complement activation have not been demonstrated, and the titer of antibody to IgA has diminished.
Cunningham-Rundles
C
C
Wong
S
S
Björkander
J
J
Hanson
L A
LA
D000361:Agammaglobulinemia / Q000276:immunology / Q000628:therapy*; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis / Q000096:biosynthesis*; D000936:Antigen-Antibody Complex / Q000378:metabolism; D003167:Complement Activation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D017098:IgA Deficiency; D007070:Immunoglobulin A / Q000276:immunology; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G / Q000627:therapeutic use*; D016756:Immunoglobulins, Intravenous; D008875:Middle Aged
D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous