Drug discovery--today and tomorrow: the role of medicinal chemistry.
Novel drugs presently introduced in the market are largely not discovered by rational design or by random screening but, rather, are products of evolution of existing leads (analogue research). It is suggested that this will change in the near future. Progress in a number of scientific disciplines will make it likely that drug design, but also systematic screening, will contribute more and more to novel drug discovery.
Freter
K R
KR
Medicinal Chemistry Department, R&D, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut 06877.
D002626:Chemistry, Pharmaceutical; D006801:Humans; D010600:Pharmacology / Q000639:trends*