Transfer of specific immunity in marrow recipients given HLA-mismatched, T cell-depleted, or HLA-identical marrow grafts.
The transfer of tetanus toxoid (TT) and diphtheria toxoid (DT) specific immunity was evaluated in 209 short-term (less than 120 days postgrafting) and 257 long-term (greater than 198 days postgrafting) non-boosted recipients after HLA-identical, HLA non-identical, and HLA-identical T cell-depleted marrow transplantation. TT or DT immunizations were not given to donors in the 6 months prior to transplant and the recipients received no immunizations post-transplantation. In 209 short-term recipients, 94% and 74% of recipients had detectable anti-TT and anti-DT titers respectively. In long-term recipients, 110 of 210 (52%) who received HLA-identical grafts, 17 of 38 (45%) who received HLA-non-identical grafts, and seven of seven (100%) who received HLA-identical T cell-depleted grafts had anti-TT titers; and 86 of 212 (40%) who received HLA-identical grafts, 11 of 38 (29%) who received HLA-non-identical grafts, and four of seven (57%) who received HLA-identical T cell-depleted grafts had anti-DT titers. When compared to non-boosted normal donor and control subjects, the magnitudes of anti-TT and anti-DT titers from the recipients were comparable to controls. These data show that transferred specific immunity is detectable in long-term recipients of T cell-depleted or HLA-non-identical grafts without immunizations of donors or recipients before or after transplantation.
Lum
L G
LG
Fred Hutchinson Cancer Research Center, University of Washington, Seattle.
Noges
J E
JE
Beatty
P
P
Martin
P J
PJ
Deeg
J
J
Doney
K C
KC
Loughran
T
T
Sullivan
K M
KM
Witherspoon
R P
RP
Thomas
E D
ED
D000906:Antibodies / Q000032:analysis; D016026:Bone Marrow Transplantation; D004168:Diphtheria Toxoid / Q000276:immunology; D006086:Graft vs Host Disease / Q000276:immunology; D006680:HLA Antigens; D006801:Humans; D007116:Immunization, Passive; D007156:Immunologic Memory; D008212:Lymphocyte Depletion; D013601:T-Lymphocytes / Q000276:immunology; D013745:Tetanus Toxoid / Q000276:immunology; D013997:Time Factors; D014181:Transplantation Immunology
D000906:Antibodies; D004168:Diphtheria Toxoid; D006680:HLA Antigens; D013745:Tetanus Toxoid