[Immunohistochemical studies of the histogenesis of dermatofibrosarcoma protuberans].
Paraffin-embedded tissue sections taken from 16 patients with dermatofibrosarcoma protuberans were stained by means of the peroxidase-antiperoxidase technique using antibodies against S 100 protein, NSE, Leu 7, lysozyme, alpha-1 antitrypsin, alpha-1 antichymotrypsin, cytokeratin, desmin, vimentin, and factor VIII. Most of the tumor cells showed positive reactions to vimentin. Only 1-3% of the cells within the tumor area answered to the histiocytic markers lysozyme, alpha-1 antitrypsin, and alpha-1 antichymotrypsin. The remaining antibodies investigated did not react with the tumor cells. Our results support a fibroblastic, and contradict a neural or histiocytic, histogenesis of dermatofibrosarcoma protuberans.
Lautier
R
R
Klinik für Dermatologie und Venerologie der Medizinischen Universität zu Lübeck.
Wolff
H H
HH
Jones
R E
RE
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D005354:Fibrosarcoma / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase
Immunhistochemische Untersuchungen zur Histogenese des Dermatofibrosarcoma protuberans.