[In vitro activity of penicillin G and amoxicillin against 14 strains of Streptococcus milleri].
The MIC/MBC of penicillin G and amoxicillin were studied for 14 strains of Streptococcus milleri from varied specimens of hospitalized patients by broth dilution method. The MIC of penicillin G are between 0.015 and 0.12 mg/l, MIC of amoxicillin between 0.015 and 0.5 mg/l. The MBC of penicillin G are between 0.015 and 0.12 mg/l, MBC of amoxicillin between 0.12 and 0.5 mg/l. MBC/MIC of penicillin G are between 1 and 8. MBC/MIC of amoxicillin are between 1 and 16. The bactericidal effect was studied by killing curves on 5 strains at 2, 4, 6 and 18 hours at different concentrations of penicillin G (0.1, 0.2, 1 mg/l) and of amoxicillin (0.2, 0.5, 1 mg/l). For 3 strains we observed a bactericidal effect with 99.9% or 99.99% of killing between the 6th and 18th hour without difference between penicillin G and amoxicillin, the two further strains were killed respectively by 0.1 mg/l of penicillin G and 0.5 mg/l of amoxicillin and by 0.2 mg/l of penicillin G and 0.5 mg/l of amoxicillin.
Berardi-Grassias
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L
Laboratoire de Microbiologie, Centre Hospitalier Francois-Quesnay, Mantes-La-Jolie.
Le Pennec
M P
MP
Chauvière
P
P
D000658:Amoxicillin / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000008:administration & dosage / Q000494:pharmacology*; D013290:Streptococcal Infections / Q000188:drug therapy; D013291:Streptococcus / Q000187:drug effects* / Q000302:isolation & purification
D000658:Amoxicillin; D010400:Penicillin G
Activité in vitro de la pénicilline G et de l'amoxicilline vis-à-vis de quatorze souches de Streptococcus milleri.