title: Adjuvant chemotherapy in T3 carcinoma of the bladder. A prospective trial: preliminary report.
abstract: We report the early results of a multi-centre, randomised prospective trial of neoadjuvant and maintenance chemotherapy with methotrexate (MTX) in 376 patients with advanced (T3) carcinoma of the bladder. In patients under 65 years of age, treatment consisted of radical radiotherapy (64 Gy) or, in some centres, pre-operative radiotherapy (44 Gy) and elective cystectomy. All patients over 65 had radical radiotherapy. MTX was administered to 188 patients. There was no increase in toxicity attributable to the MTX. MTX did not significantly increase the proportion of patients whose tumours responded to radiotherapy; 50% (70/141) responded to radiotherapy and 56% (76/136) to MTX radiotherapy. The development of metastases and survival was also similar in both groups (3-year survival: radiotherapy 37.3%, MTX + radiotherapy 38.6%). We report the logistic difficulties of the administration of prolonged courses of maintenance chemotherapy. Further controlled trials of neo-adjuvant chemotherapy in advanced bladder cancer are required, involving more active regimes.
authors.affiliation: Department of Urology, Royal Marsden Hospital, London.
authors.forename: R J
authors.initials: RJ
authors.lastname: Shearer
authors.forename: C F
authors.initials: CF
authors.lastname: Chilvers
authors.forename: H J
authors.initials: HJ
authors.lastname: Bloom
authors.forename: J M
authors.initials: JM
authors.lastname: Bliss
authors.forename: A
authors.initials: A
authors.lastname: Horwich
authors.forename: A
authors.initials: A
authors.lastname: Babiker
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011446:Prospective Studies; D011897:Random Allocation; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy
chemical_list: D008727:Methotrexate