Islet cells-tight junctions: changes in its number induced by glucose.
Cell-tight junctions were counted in rat isolated islets incubated for different periods of time in the presence of different extracellular glucose concentrations. The number of tight junctions increased as a function of the length of the incubation period and the concentration of glucose. These results would suggest the involvement of tight junctions in the regulatory process of glucose-induced insulin secretion. Key words: Tight junctions, islet cell ultrastructure, isolated islets, islet incubation, glucose-induced insulin secretion, islet cell secretory function.
Semino
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MC
CENEXA, Centro de Endocrinología Experimental y Aplicada (UNLP-CONICET), Facultad de Ciencias Médicas, La Plata, Argentina.
de Gagliardino
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EE
Gagliardino
J J
JJ
D000818:Animals; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007365:Intercellular Junctions / Q000187:drug effects* / Q000648:ultrastructure; D007515:Islets of Langerhans / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D005947:Glucose