title: Fatal Yersinia enterocolitica septicemia complicated by unique hemosiderosis. A case report.
abstract: A fatal case of Yersinia enterocolitica septicemia which was complicated by unique hemosiderosis is reported. On admission, the patient had diabetes and showed unusual hyperferritinemia. Postmortem examination revealed that the liver was studied with abscesses, and Yersinia antigen was expressed in foamy macrophages within these abscesses. Moreover, the cadaver showed generalized hemosiderin deposition, which was mainly observed in the liver and, to lesser degrees, in the pancreas, spleen, lymph nodes, brain, thyroid and kidneys. Since there was no apparent cause of the hyperferritinemia and generalized hemosiderosis, consideration was given to possible primary hemochromatosis. However, no liver or pancreatic fibrosis was demonstrated. Kupffer cells were also loaded with hemosiderin, and therefore it was considered that these cells had lost their ability to phagocytize the microorganism adequately, leading to major liver involvement. Interestingly, hemosiderin deposits in the kidneys were mostly present in glomerular epithelial cells. To our knowledge, this unique presentation has not been previously described in humans.
authors.affiliation: Department of Pathology, Ohashi Hospital, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Shibuya
authors.forename: M
authors.initials: M
authors.lastname: Ando
authors.forename: K
authors.initials: K
authors.lastname: Kuroda
authors.forename: S
authors.initials: S
authors.lastname: Naoe
authors.forename: T
authors.initials: T
authors.lastname: Maruyama
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000150:complications* / Q000401:mortality / Q000473:pathology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000473:pathology; D005455:Fluorescent Antibody Technique; D006486:Hemosiderosis / Q000150:complications / Q000473:pathology; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D018805:Sepsis / Q000150:complications* / Q000401:mortality / Q000473:pathology; D015008:Yersinia enterocolitica / Q000472:pathogenicity*