title: [Tissue colonization of expanded polytetrafluoroethylene in healthy cornea in the view of its use as a support in keratoprosthesis].
abstract: The biocompatibility of polytetrafluoroethylene (E. PTFE) keratoprosthetic skirts was studied for periods of observation from 4 to 14 weeks. In a first experimental study, the authors showed that E. PTFE was well tolerated but without fibrovascular ingrowth. In this study, eight perforating keratoplasties were performed and a disk of E. PTFE with a diameter of 4.5 mm was sutured in and covered with a conjunctival flap. The results show that E. PTFE allows fibrovascular ingrowth without a significant foreign body response or encapsulation. Coverage of E. PTFE with conjunctival was essential for fibrovascular ingrowth and to prevent extrusion and rejection.
authors.affiliation: Service d'Ophtalmologie, Hôtel-Dieu, Paris.
authors.forename: J M
authors.initials: JM
authors.lastname: Legeais
authors.forename: G
authors.initials: G
authors.lastname: Renard
authors.forename: M
authors.initials: M
authors.lastname: Savoldelli
authors.forename: N
authors.initials: N
authors.lastname: Keller
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D003315:Cornea / Q000166:cytology; D016039:Corneal Transplantation; D004728:Endothelium, Corneal / Q000166:cytology; D004847:Epithelial Cells; D008297:Male; D008855:Microscopy, Electron, Scanning; D011138:Polytetrafluoroethylene; D011817:Rabbits; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D011138:Polytetrafluoroethylene
vernacular_title: Etude de la colonisation tissulaire du polytétrafluoroéthylène expansé en cornée saine en vue de son utilisation comme support de kératoprothèse.