title: Occurrence of spontaneous diabetes mellitus in a cynomolgus monkey (Macaca fascicularis) and impaired glucose tolerance in its descendants.
abstract: Spontaneous diabetes mellitus was diagnosed in a cynomolgus monkey. Clinical and pathological features, such as abnormal glucose tolerance, loss of insulin response, or degeneration of pancreatic beta-cells, resemble human noninsulin-dependent diabetes mellitus. Two descendants of the monkey have developed impaired glucose tolerance and insulin response. Genetic factors seem involved in the appearance of carbohydrate intolerance in this family group of monkeys.
authors.affiliation: Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd., Shizuoka; Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yasuda
authors.forename: M
authors.initials: M
authors.lastname: Takaoka
authors.forename: T
authors.initials: T
authors.lastname: Fujiwara
authors.forename: M
authors.initials: M
authors.lastname: Mori
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics / Q000662:veterinary*; D005260:Female; D005951:Glucose Tolerance Test / Q000662:veterinary; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000473:pathology; D008251:Macaca; D008252:Macaca fascicularis; D008297:Male; D008992:Monkey Diseases / Q000097:blood / Q000235:genetics*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides