Parkinsonism: a clinical marker of exposure to neurotoxins.
Parkinson must be viewed as a final common pathway resulting from a variety of neuropathological lesions which interfere with the integrity of the nigrostriatal system or its output. Exposure to a wide variety of neurotoxic compounds, namely, carbon monoxide, carbon disulfide, manganese and MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), are associated with parkinsonism that has a varying neuropathology, which will be discussed.
Bleecker
M L
ML
Johns Hopkins University School of Medicine, Department of Neurology, Francis Scott Key Medical Center, Baltimore, MD 21224.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D002246:Carbon Disulfide / Q000633:toxicity; D002248:Carbon Monoxide / Q000633:toxicity; D004195:Disease Models, Animal; D006801:Humans; D020149:Manganese Poisoning; D009498:Neurotoxins; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D011725:Pyridines / Q000633:toxicity
D009498:Neurotoxins; D011725:Pyridines; D002248:Carbon Monoxide; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D002246:Carbon Disulfide