[Transmethylation inhibitors prevent the spontaneous reinitiation of meiosis in denuded ovocytes of mice].
Methyltransferase inhibitors such as 5'-methyl-5'-thioadenosine (MTA), 5'-deoxy-5'-isobutylthioadenosine (SIBA) and 5'-deoxy-5'-isobutylthio-3-deaza-adenosine (3-deaza-SIBA) maintain the meiotic prophase block in denuded mouse oocytes. The inhibitory effect is dose-dependent and reversible. This inhibition is potentiated by forskolin and by the phorbol 12,13 dibutyrate (PD Bu), a tumor-promoting phorbol ester.
Urner
F
F
Schorderet-Slatkine
S
S
D000818:Animals; D002273:Carcinogens; D005576:Colforsin / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D008540:Meiosis / Q000187:drug effects*; D008745:Methylation; D008780:Methyltransferases / Q000037:antagonists & inhibitors*; D051379:Mice; D009865:Oocytes / Q000166:cytology*; D015240:Phorbol 12,13-Dibutyrate; D010703:Phorbol Esters / Q000494:pharmacology; D014372:Tubercidin / Q000031:analogs & derivatives / Q000494:pharmacology
D002273:Carcinogens; D010703:Phorbol Esters; D005576:Colforsin; D015240:Phorbol 12,13-Dibutyrate; C017194:5'-deoxy-5'-(isobutylthio)-3-deazaadenosine; D008780:Methyltransferases; D014372:Tubercidin
Les inhibiteurs de transméthylation empêchent la réinitiation spontanée de la méiose chez l'ovocyte dénudé de souris.