Effects of gonadotropin-releasing hormone analogs on cis-platinum-induced spermatogenic damage.
In order to test the hypothesis that pretreatment with gonadotropin-releasing hormone (GnRH) analogs might ameliorate cytotoxic drug-induced testicular damage, mature male Wistar rats were pretreated for 2 weeks with a GnRH superactive agonist or a pure GnRH antagonist prior to, and for 1 week after, a 5 mg/kg intraperitoneal dose of cis-platinum. Despite inhibition of testicular function by both GnRH analogs prior to cis-platinum administration, there was no evidence of protection or enhanced recovery of spermatogenesis at 6 and 12 weeks after cis-platinum treatment, and spermatogenesis was significantly further depressed at both time-points by both GnRH agonist and antagonist pretreatment. This suggests that pretreatment with GnRH analogs in the rat does not protect spermatogenesis from cis-platinum-induced testicular damage within up to two spermatogenic cycles and that hypogonadism at the time of cytotoxic drug treatments may aggravate testicular damage.
Handelsman
D J
DJ
Department of Medicine, University of Sydney, Australia.
Peng
S
S
Sikka
S
S
Swerdloff
R S
RS
Rajfer
J
J
D000818:Animals; D002945:Cisplatin / Q000009:adverse effects*; D007248:Infertility, Male / Q000188:drug therapy*; D008297:Male; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects
D010906:Pituitary Hormone-Releasing Hormones; D002945:Cisplatin