title: Double-blind, randomized comparison of 24 weeks of norfloxacin and 12 weeks of norfloxacin followed by 12 weeks of placebo in the therapy of complicated urinary tract infection.
abstract: We evaluated the benefits of prolonging norfloxacin therapy from 12 to 24 weeks for complicated urinary tract infection in a double-blind, randomized, placebo-controlled study. During the second 12 weeks, norfloxacin was superior to placebo (P less than 0.05) in suppressing bacteriuria. Adverse effects were common but mostly confined to the initial 12 weeks.
authors.affiliation: Department of Medicine, University of Manitoba, Winnipeg, Canada.
authors.forename: G J
authors.initials: GJ
authors.lastname: Sheehan
authors.forename: G K
authors.initials: GK
authors.lastname: Harding
authors.forename: D A
authors.initials: DA
authors.lastname: Haase
authors.forename: M J
authors.initials: MJ
authors.lastname: Thomson
authors.forename: B
authors.initials: B
authors.lastname: Urias
authors.forename: J K
authors.initials: JK
authors.lastname: Kennedy
authors.forename: D J
authors.initials: DJ
authors.lastname: Hoban
authors.forename: A R
authors.initials: AR
authors.lastname: Ronald
mesh_terms: D001437:Bacteriuria / Q000188:drug therapy; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D006801:Humans; D009643:Norfloxacin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy*
chemical_list: D009643:Norfloxacin