Disodium cromoglycate fails to prevent the rise in pulmonary artery pressure in hypoxic chronic bronchitis and emphysema.
Animal studies have suggested that stabilising mast cells may reduce the rise in pulmonary artery pressure which is produced by hypoxia. In six patients with stable hypoxic chronic bronchitis and emphysema, we have compared the pulmonary artery pressure at rest and on exercise before and after inhaling disodium cromoglycate (DSCG). The increase in heart rate was the same after each period of exercise (17 beats/min increase on placebo; 16 beats/min on DSCG), as was fall in arterial oxygen saturation (6% on placebo; 6% on DSCG). The subsequent rise in pulmonary artery pressure (PAP) during exercise was also not significantly different between placebo and DSCG. We conclude that 80 mg of aerosolised DSCG does not modify the pulmonary artery pressure in patients with chronic bronchitis and emphysema either at rest or during exercise.
Rhind
G B
GB
MacNee
W
W
Flenley
D C
DC
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D001991:Bronchitis / Q000097:blood / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood; D002908:Chronic Disease; D004205:Cromolyn Sodium / Q000494:pharmacology*; D005541:Forced Expiratory Volume; D006339:Heart Rate; D006801:Humans; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D005082:Physical Exertion; D011651:Pulmonary Artery / Q000187:drug effects / Q000503:physiopathology*; D011656:Pulmonary Emphysema / Q000097:blood / Q000503:physiopathology*; D014797:Vital Capacity
D002245:Carbon Dioxide; D004205:Cromolyn Sodium; D010100:Oxygen