title: Atrophoderma (Pasini-Pierini). Findings on direct immunofluorescent, monoclonal antibody, and ultrastructural studies.
abstract: A patient with atrophoderma (Pasini-Pierini) was studied. Microscopic examination showed small collections of mononuclear cells around dermal blood vessels. Electron microscopic study demonstrated macrophages and lymphocytes around vessels and between fibers in the dermis; the epidermis, dermis, collagen, and elastic fibers appeared normal. Monoclonal antibody studies of the cells in the perivascular infiltrate demonstrated cells reacting with anti-Leu-1 (pan-T-cell antibody), anti-Leu-3a (the helper/inducer T-cell antibody), and OKM 1 antibody-reacting cells (macrophages). Direct immunofluorescent studies showed IgM and C3 staining in the small blood vessels of the papillary dermis, scattered IgM cytoids at the basement membrane, and focal fibrinogen in the mid-dermis. Mononuclear cells in the perivascular infiltrate, similar in type and percentage concentration, have been demonstrated also in patients with anetoderma, another rare atrophic cutaneous disorder. Macrophages and T lymphocytes around papillary dermal blood vessels may play a role in the pathogenesis of atrophoderma and anetoderma.
authors.affiliation: Department of Dermatology Medical College of Wisconsin, Milwaukee.
authors.forename: A
authors.initials: A
authors.lastname: Berman
authors.forename: G D
authors.initials: GD
authors.lastname: Berman
authors.forename: R K
authors.initials: RK
authors.lastname: Winkelmann
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000032:analysis; D000911:Antibodies, Monoclonal; D001284:Atrophy; D001898:Borrelia / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008854:Microscopy, Electron; D012594:Scleroderma, Localized / Q000276:immunology; D012867:Skin / Q000473:pathology / Q000648:ultrastructure; D012871:Skin Diseases / Q000276:immunology / Q000473:pathology*
chemical_list: D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal