Regression of rat primary mammary tumors following dietary d-limonene.
The effects of d-limonene on rat mammary tumors were investigated. Following the appearance of mammary tumors induced by 7,12-dimethylbenz[a]anthracene in female (W/Fu X F344)F2 rats, animals were assigned to pairs in which 1 rat was fed a diet containing 10% d-limonene and the other was pair fed an isocaloric diet containing 10% cellulose. There was a highly significant increase in the regression of the first tumors in the rats fed d-limonene. In addition, d-limonene given at this time inhibited the formation of subsequent multiple tumors in these rats.
Elegbede
J A
JA
Elson
C E
CE
Tanner
M A
MA
Qureshi
A
A
Gould
M N
MN
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000970:Antineoplastic Agents; D053138:Cyclohexenes; D005260:Female; D000077222:Limonene; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D010173:Palpation; D051381:Rats; D011919:Rats, Inbred Strains; D013729:Terpenes / Q000008:administration & dosage* / Q000627:therapeutic use; D013997:Time Factors
D000970:Antineoplastic Agents; D053138:Cyclohexenes; D013729:Terpenes; D015127:9,10-Dimethyl-1,2-benzanthracene; D000077222:Limonene