title: Metabolic acidosis. Development in two patients receiving a potassium-sparing diuretic and total parenteral nutrition.
abstract: Two patients developed a metabolic acidosis associated with a normal undetermined anion concentration while receiving a potassium-sparing diuretic and total parenteral nutrition. In both cases the metabolic acidosis resolved within one week after discontinuing administration of the diuretic. The use of potassium-sparing diuretics in a patient receiving total parenteral nutrition requires caution and continued monitoring for this potential drug-nutrient interaction.
authors.forename: R F
authors.initials: RF
authors.lastname: Kushner
authors.forename: M D
authors.initials: MD
authors.lastname: Sitrin
mesh_terms: D000138:Acidosis / Q000139:chemically induced* / Q000378:metabolism; D000328:Adult; D000368:Aged; D004573:Electrolytes / Q000032:analysis; D005260:Female; D006801:Humans; D007668:Kidney / Q000032:analysis; D010289:Parenteral Nutrition, Total; D013148:Spironolactone / Q000009:adverse effects*
chemical_list: D004573:Electrolytes; D013148:Spironolactone