Cyclosporin neurotoxicity in cardiac transplant recipients.
Cyclosporin toxicity may produce a wide range of neurological disorders. We report three patients whose neurological problems developed while taking cyclosporin following cardiac transplantation, but resolved rapidly when the drug was discontinued. In two cases, MRI revealed abnormalities which disappeared with clinical recovery. Blood cyclosporin concentrations were not markedly increased, and it is possible that the neurotoxic effects of cyclosporin are mediated by metabolites, through an effect on the blood-brain barrier.
Lane
R J
RJ
Regional Neurosciences Centre, Charing Cross Hospital, London, UK.
Roche
S W
SW
Leung
A A
AA
Greco
A
A
Lange
L S
LS
D000293:Adolescent; D000328:Adult; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D003524:Cyclosporins / Q000009:adverse effects*; D004827:Epilepsy / Q000139:chemically induced; D016027:Heart Transplantation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced*; D011183:Postoperative Complications / Q000209:etiology*; D011605:Psychoses, Substance-Induced / Q000209:etiology
D003524:Cyclosporins