title: A sequential study of histological and immunological changes in the skin after allogenic bone marrow transplantation.
abstract: Histological and immunopathological studies were performed on serial skin biopsies from thirteen recipients of allogenic and two recipients of autologous bone marrow transplants. Marked dermoepidermal infiltration with Leu 2a+ (OKT8+) phenotype cells was found in two patients with severe graft-versus-host disease, but the infiltration did not precede clinical onset of the graft-versus-host disease. Absence of Langerhans cells was noted during the early posttransplant period in recipients of both allogenic and autologous transplantation. Intercellular epidermal staining with anti-DR was observed in three cases, without relation to graft-versus-host disease.
authors.forename: D
authors.initials: D
authors.lastname: Guyotat
authors.forename: G
authors.initials: G
authors.lastname: Mauduit
authors.forename: B
authors.initials: B
authors.lastname: Chouvet
authors.forename: J
authors.initials: J
authors.lastname: Kanitakis
authors.forename: H V
authors.initials: HV
authors.lastname: Van
authors.forename: D
authors.initials: D
authors.lastname: Fiere
authors.forename: J
authors.initials: J
authors.lastname: Thivolet
mesh_terms: D000293:Adolescent; D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000032:analysis; D016026:Bone Marrow Transplantation; D006086:Graft vs Host Disease / Q000276:immunology* / Q000473:pathology; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology; D007938:Leukemia / Q000628:therapy; D008214:Lymphocytes / Q000276:immunology; D012867:Skin / Q000276:immunology / Q000473:pathology*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II