Meckel syndrome with polysplenia: case report and review of the literature.
A 19-week gestation female fetus had multiple anomalies suggesting Meckel syndrome with polysplenia. In over 200 reported cases of Meckel syndrome, only 2 similar cases are documented. Both were male infants, one with bilateral left-sidedness (polysplenia), the other with bilateral right-sidedness (M-anisosplenia). Meckel syndrome is a complex MCA (multiple congenital anomaly) syndrome. Thus, the finding of polysplenia is to be interpreted as another such midline anomaly, rather than as a causally independent malformation.
Shen-Schwarz
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Department of Pathology, Magee-Womens Hospital, Pennsylvania.
Dave
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D000015:Abnormalities, Multiple; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D013577:Syndrome