Cardioventilator effects of TRH in anaesthetized rats: role of the brain stem.
Cardioventilator responses were studied in anaesthetized rats after injections of TRH into either the lateral (i.c.v. lat) or the fourth (i.c.v. IV) cerebral ventricles. TRH induced a more rapid hypertensive effect i.c.v. IV than i.c.v. lat. Blocking of the cerebral aqueduct abolished the hypertensive and tachypnoeic effects of TRH i.c.v. lat but not those of TRH i.c.v. IV. It is concluded that TRH increased blood pressure and ventilation rate via brain stem structures close to the fourth ventricle.
Paakkari
I
I
Nurminen
M L
ML
Sirén
A L
AL
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001933:Brain Stem / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D012119:Respiration / Q000187:drug effects*; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000502:physiology*; D013990:Tidal Volume
D013973:Thyrotropin-Releasing Hormone