Post-traumatic cutaneous mucormycosis in diabetes mellitus. Short-term antifungal therapy.
Mucormycosis is infrequently encountered in the pediatric population in any of its forms (nasopharyngeal, disseminated, pulmonary, or cutaneous) and generally is associated with the immunocompromised host. We present an adolescent with poorly controlled diabetes mellitus who developed a progressive skin lesion 3 weeks after a motor vehicle accident. Rhizopus species was isolated from the lesion, and the biopsy revealed a fungal vasculopathy. Control of her diabetes, aggressive surgical intervention and a 10-day course of antifungal therapy (amphotericin B) resulted in a favorable outcome. This article illustrates the importance of considering cutaneous fungal infections, especially those in the class zygomycetes, in the diabetic patient with unusual, severe or persistent skin lesions. Early recognition is essential in order to avoid morbidity and mortality from this unusual opportunistic infection.
Ryan-Poirier
K
K
Department of Pediatrics, University of Tennessee, Memphis.
Eiseman
R M
RM
Beaty
J H
JH
Hunt
P G
PG
Burghen
G A
GA
Leggiadro
R J
RJ
D000063:Accidents, Traffic; D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003881:Dermatomycoses / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006801:Humans; D009091:Mucormycosis / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D012233:Rhizopus / Q000302:isolation & purification; D016038:Skin Transplantation; D014946:Wound Infection / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery
D000666:Amphotericin B