Neuroendocrinology of pyridoxine deficiency.
Dihydroxyphenylalanine decarboxylase and 5-hydroxytryptophan decarboxylase respectively have high and low affinities for pyridoxal phosphate. In the pyridoxine-deficient animal, hypothalamic serotonin content is significantly reduced without any change in catecholamine levels. Hypothalamic neurotransmitters affect the hypothalamo-pituitary-end organ axes. Specifically, the decrease in hypothalamic serotonin in the pyridoxine-deficient rat results in tertiary hypothyroidism. In addition, pineal function is affected in deficient animals due to decreased synthesis of melatonin.
Dakshinamurti
K
K
Department of Biochemistry, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Paulose
C S
CS
Viswanathan
M
M
Siow
Y L
YL
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000503:physiopathology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D026681:Vitamin B 6 Deficiency / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology
D012701:Serotonin