Sedation for endoscopy: midazolam or diazepam and pethidine?
One hundred patients received either diazepam given with pethidine, antagonized with naloxone, or midazolam alone in a double-blind randomized study of sedation for upper gastrointestinal endoscopy. Midazolam produced better amnesia for the procedure (P less than 0.0001) but diazepam and pethidine resulted in less retching during the procedure (P less than 0.01) and less sedation after the procedure, as judged by a simple performance test (P less than 0.02) and patient recall of results (P less than 0.02).
Boldy
D A
DA
Department of Medicine, Wycombe General Hospital, High Wycombe, Bucks.
Lever
L R
LR
Unwin
P R
PR
Spencer
P A
PA
Hoare
A M
AM
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000008:administration & dosage*; D004311:Double-Blind Method; D004724:Endoscopy; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D008614:Meperidine / Q000008:administration & dosage*; D008874:Midazolam / Q000008:administration & dosage*; D008875:Middle Aged
D006993:Hypnotics and Sedatives; D008614:Meperidine; D003975:Diazepam; D008874:Midazolam