Role of GM-CSF in phagocyte recruitment and regulation of c-fos protooncogene expression.
Recombinant GM-CSF induced migration across polycarbonate filters of monocytes and polymorphonuclear leukocytes. Checkerboard analysis revealed that induction of phagocyte migration involved actual chemotaxis. Hence GM-CSF, released by activated endothelium and leukocytes, may play a role in phagocyte recruitment to amplify resistance against noxious agents. Activation of leukocytes by GM-CSF was associated with early, transient augmentation of the expression of the c-fos protooncogene. c-fos expression may be associated with functional reprogramming of phagocytes by this cytokine.
Wang
J M
JM
Instituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Chen
Z G
ZG
Colotta
F
F
Mantovani
A
A
D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003115:Colony-Stimulating Factors / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes / Q000187:drug effects / Q000502:physiology*; D010586:Phagocytes / Q000187:drug effects / Q000502:physiology*; D011519:Proto-Oncogenes / Q000187:drug effects; D011994:Recombinant Proteins / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor