Possible involvement of protease inhibitor ras proteins in malignant transformation.
Based on our recent finding that human c-Ha-ras gene products (p21s) inhibit the activities of thiol proteinases, a possible new model for malignant transformation is proposed. The model involves a new concept that p21s can cause effects on the protein kinase activities of growth factor receptors by affecting down regulation of the receptors.
Hiwasa
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Division of Biochemistry, Chiba Cancer Center Research Institute, Japan.
D056668:Cathepsin L; D002403:Cathepsins / Q000037:antagonists & inhibitors; D002471:Cell Transformation, Neoplastic; D003546:Cysteine Endopeptidases; D010450:Endopeptidases; D006801:Humans; D008954:Models, Biological; D011480:Protease Inhibitors / Q000494:pharmacology*; D011494:Protein Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D016283:Proto-Oncogene Proteins p21(ras); D013205:Staphylococcal Protein A / Q000378:metabolism
D011480:Protease Inhibitors; D011518:Proto-Oncogene Proteins; D013205:Staphylococcal Protein A; D011494:Protein Kinases; D002403:Cathepsins; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; C534281:CTSL protein, human; D056668:Cathepsin L; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)