Ceftriaxone penetration of tissues.
Ceftriaxone (Rocephin) has shown excellent tissue and body fluid penetration after a dose of 1-2 g: concentrations well above the minimal inhibitory concentrations of most pathogens responsible for infection are detectable for more than 24 h. Data from over 60 tissues were analyzed from the literature; a selection of comparative and noncomparative studies of clinical relevance is presented.
Billstein
S A
SA
Professional Services Department, Hoffmann-La Roche Inc., Nutley, N.J.
D002437:Cefazolin / Q000493:pharmacokinetics; D002443:Ceftriaxone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004333:Drug Administration Routes; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D014018:Tissue Distribution
D002443:Ceftriaxone; D002437:Cefazolin