title: The use of animal models in research on dental implants.
abstract: The use of animal models in the study of dental implants has contributed greatly to our present understanding of the many different devices in use today. Animal testing plays a major role in assessing the safety and efficacy of dental implants. Standardized tests for determination of the toxicity and general biocompatibility responses of dental implants have been developed by the American Dental Association, the American National Standards Institute, and the Fédération Dentaire Internationale. To date, animal testing has shown the nature of soft tissue attachment to implants and the types of interfacial tissues within bone sites. There have been increased studies correlating animal tests with in vitro analysis and human studies. Additional development of testing remains to be accomplished to show the effects of function on host tissue and the long-term safety of dental implants.
authors.affiliation: Department of Stomatology, State University of New York, School of Dental Medicine, Buffalo.
authors.forename: J R
authors.initials: JR
authors.lastname: Natiella
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D003757:Dental Implantation; D005549:Foreign-Body Reaction
chemical_list: D001672:Biocompatible Materials