[Effect of lormetazepam, triazolam and flunitrazepam on rapid eye movements, K-complexes and sleep spindles in normal probands].
"Equipotential" doses of lormetazepam, triazolam and flunitrazepam were tested regarding their influence on K-complexes, sleep spindles and rapid eye movements. The receptor affinity was used to determine the equipotency. In this respect triazolam, lormetazepam and flunitrazepam show a relationship of 1:2:4. Lormetazepam, however, showed only slight changes of the three neurophysiological parameters even when given as double dosage. Triazolam and flunitrazepam reduce K-complexes considerably, increase sleep spindles enormously and reduce REM activity markedly; both substances suppress the first REM period, flunitrazepam even the second one. All three of the benzodiazepines have the same effect on the dissociation of K-complexes and sleep spindles; epochs with K-complexes or sleep spindles are favored compared to epochs with K-complexes and sleep spindles. The general reduction of K-complexes and the increase in sleep spindles can be interpreted as a sleep protective function. When deciding on the dosage, however, REM-suppression should be used as a guide since it has the strongest effect on the cyclic structure of sleep which nowadays is considered to be the safest evidence of well balanced sleep behavior.
D000328:Adult; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D004569:Electroencephalography; D005260:Female; D005445:Flunitrazepam / Q000494:pharmacology*; D006801:Humans; D008140:Lorazepam / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D012890:Sleep / Q000187:drug effects / Q000502:physiology*; D012895:Sleep, REM / Q000187:drug effects*; D014229:Triazolam / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D014229:Triazolam; D005445:Flunitrazepam; C023842:lormetazepam; D008140:Lorazepam
Der Einfluss von Lormetazepam, Triazolam und Flunitrazepam auf die schnellen Augenbewegungen, K-Komplexe und Schlafspindeln gesunder Probanden.