Reduction in 2-deoxy-D-glucose analgesia following acute, but not chronic antidepressant treatment.
Acute, but not chronic, antidepressant treatment potentiates the analgesic responses following cold-water swims. The present study evaluated the effects of acute (10 mg/kg) and chronic (10 mg/kg, twice daily over 7 days) pretreatment with desipramine (DMI) upon the analgesic response following 2-deoxy-D-glucose (2DG) in rats as measured by the jump test. Acute, but not chronic, DMI pretreatment significantly reduced 2DG analgesia. These effects are discussed in terms of the heterogeneity of pain-inhibitory responses.
D000700:Analgesics; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D003837:Deoxy Sugars / Q000037:antagonists & inhibitors*; D003847:Deoxyglucose / Q000037:antagonists & inhibitors*; D003891:Desipramine / Q000494:pharmacology; D004347:Drug Interactions; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming
D000700:Analgesics; D000928:Antidepressive Agents; D003837:Deoxy Sugars; D003847:Deoxyglucose; D003891:Desipramine