Albumin does not inhibit endothelium-dependent relaxation.
Bovine serum albumin which is fatty acid free, enhances the endothelium-dependent vasodilating effect of various agonists like acetylcholine, carbachol, ATP, ADP and ionophore on rat aortic rings. The maximum effect was observed in buffers containing 5% albumin. Albumin has no effect on rings devoid of endothelium. On the other hand, both plasma and serum completely abolished the vasodilating effect of these agents.
D000109:Acetylcholine / Q000494:pharmacology; D000227:Adenine Nucleotides / Q000494:pharmacology; D000818:Animals; D001769:Blood; D000001:Calcimycin / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D004727:Endothelium / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D012710:Serum Albumin, Bovine / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects*
D000227:Adenine Nucleotides; D012710:Serum Albumin, Bovine; D000001:Calcimycin; D002217:Carbachol; D000109:Acetylcholine