DNA adducts of medicinal drugs: some selected examples.
A few selected medicinal drugs, diamminedichloroplatinum (II) compounds, mitomycin C, psoralens, and diethylstilbestrol are briefly reviewed with respect to the formation and biological significance of their DNA adducts. Different types of adducts, e.g., DNA intrastrand crosslinks, DNA interstrand crosslinks, or monoadducts appear to represent the critical DNA lesions of the different drugs, accounting for cytotoxicity and carcinogenicity. Thus, these examples serve to illustrate the complexity of DNA adduct formation and its biological sequelae.
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D002945:Cisplatin / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D004054:Diethylstilbestrol / Q000378:metabolism*; D011564:Furocoumarins / Q000378:metabolism*; D016685:Mitomycin; D008937:Mitomycins / Q000378:metabolism*
D000970:Antineoplastic Agents; D011564:Furocoumarins; D008937:Mitomycins; D016685:Mitomycin; D004054:Diethylstilbestrol; D004247:DNA; D002945:Cisplatin