title: Changes in the connective tissue and decrease in the number of mast cells in the testes of men with alcoholic and non-alcoholic cirrhosis.
abstract: The testicular connective tissue of patients with alcoholic and non-alcoholic cirrhosis was studied by Picrosirius staining for collagen fibres and electron microscopy, and then compared with the connective tissue of normal testes. Under polarized light, the interstitial connective tissue in the testes of patients with alcoholic and non-alcoholic cirrhosis exhibited a green birefringence which did not appear in normal testes, and the orange birefringence characteristic of the tunica propria in the testes of both cirrhotic and normal males was less developed in cirrhosis. This suggests that a connective tissue, consisting of smaller and less ordered collagen fibre bundles than those in the tunica propria is formed in the testicular interstitium of cirrhotic males, and the collagen fibre bundles of the tunica propria are less developed than in normal testes. The appearance of connective tissue was associated with a decrease in the number of mast cells in the testes of cirrhotic males suggesting the involvement of mast cells in the synthesis, packing, and organization of collagen fibres. The cause of the decrease in mast cell numbers may be related to hormone alterations, in particular testosterone deficiency.
mesh_terms: D000328:Adult; D000368:Aged; D002452:Cell Count; D003094:Collagen / Q000032:analysis; D003238:Connective Tissue / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D008099:Liver / Q000648:ultrastructure; D008103:Liver Cirrhosis / Q000378:metabolism / Q000473:pathology*; D008104:Liver Cirrhosis, Alcoholic / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008407:Mast Cells / Q000473:pathology*; D008875:Middle Aged; D013737:Testis / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D003094:Collagen