title: [Cholestasis in total parenteral nutrition. A review].
abstract: Intrahepatic cholestasis is a frequent, however, unresolved complication of total parenteral nutrition in infancy. A frequency of 10-50% is reported. The concentration of serum bile acids seems to be a sensitive indicator for a beginning cholestasis. As typical histological alterations of the liver are considered: inflammatory portal reaction, fibrosis and proliferation of bile ducts. As important components of the obviously multifactorial etiology are considered: lacking oral alimentation, fetal bile acid synthetic pathways, amino acid toxicity, hypoalbuminemia, sepsis and substrate excess.
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D001724:Birth Weight; D002780:Cholestasis, Intrahepatic / Q000378:metabolism*; D005217:Fat Emulsions, Intravenous / Q000378:metabolism; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000378:metabolism; D010289:Parenteral Nutrition, Total; D018805:Sepsis / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D000596:Amino Acids; D001647:Bile Acids and Salts; D005217:Fat Emulsions, Intravenous; D012709:Serum Albumin; D001663:Bilirubin
vernacular_title: Cholestase bei totaler parenteraler Ernährung (TPE). Eine Ubersicht.