title: [Monitoring of medication in optimalization of preoral theophylline in long-term care].
abstract: A narrow therapeutic index, considerable interpatients variability of clearance and biotransformation, rapid alterations of pharmacokinetics point out theophylline to a problem-drug. An effective long-term treatment with this drug is only possible with retard-preparations. For a certain therapy a drug monitoring-controlling the theophylline-concentration in the serum--is necessary, in what extend and under which conditions is discussed in detail.
mesh_terms: D003692:Delayed-Action Preparations; D006801:Humans; D008134:Long-Term Care; D008171:Lung Diseases / Q000188:drug therapy; D008991:Monitoring, Physiologic; D013183:Sputum / Q000032:analysis; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use
chemical_list: D003692:Delayed-Action Preparations; D013806:Theophylline
vernacular_title: Uberwachung der Medikation bei der Optimierung der peroralen Theophyllin-Langzeitbehandlung.