[A new promotor of nerve growth: naftidrofuryl].
20 day-old rat thoracic dorsal root ganglia were grown for 48 hrs. in Iscove's medium supplemented with 8% fetal calf serum and 600 mg/100 ml glucose. Naftidrofuryl was added at 10(-6), 10(-7), 10(-8) and 10(-9) M concentrations to the culture medium. The 10(-7) and 10(-8) M concentrations induced a statistically significant increase of the number (30 to 40%; p = .0054 and .0016, respectively) and length (20 to 30%; p = .0012 and .001, respectively) of neurites of the outgrowth measured after Bodian's protargol impregnation. The width of the cell spread in the outgrowth was also enlarged at the 10(-7) and 10(-8) M concentrations (18 to 26%; p = .0012; p less than .0001, respectively).
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D046508:Culture Techniques; D004622:Embryo, Mammalian; D005260:Female; D005663:Furans / Q000494:pharmacology*; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects; D009257:Nafronyl / Q000494:pharmacology*; D009417:Nerve Tissue / Q000187:drug effects* / Q000254:growth & development; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D005663:Furans; D009257:Nafronyl
Un nouveau promoteur de croissance nerveuse: le naftidrofuryl.