title: [Epilepsy and pregnancy--principles of therapy].
abstract: Special aspects of antiepileptic therapy during pregnancy in epileptic women are described. A monotherapy should be preferred. Due to changes in the pharmacokinetics of antiepileptic drugs, plasma level checks must be performed every four weeks during early pregnancy. The possible teratogenetic effects of anticonvulsants and other factors tending to increase of malformation rate are discussed. An explanation is given for the use of prophylactic folic acid and Vitamin K treatment in connection with antiepileptic therapy. The benefits of counselling prior to pregnancy are discussed.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000927:Anticonvulsants / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D001942:Breast Feeding; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007700:Kinetics; D008134:Long-Term Care; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D014812:Vitamin K / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D014812:Vitamin K; D005492:Folic Acid
vernacular_title: Epilepsie und Schwangerschaft--Grundsätze der Therapie.