Pulmonary reaction associated with transfusion of plasma containing anti-5b.
A patient developed an acute respiratory distress syndrome with lung infiltrates during a transfusion of plasma. The transfused plasma was shown to contain a potent leucocyte agglutinating antibody of IgG type with anti-5b specificity, reactive with the patient's cells. A review of the literature on similar transfusion-related syndromes showed an association with more of less well-defined white cell antibodies, mainly in the donors' plasma. The majority of donors were multiparous women. The anti-5b in our donor was demonstrated only by granulocyte agglutination technique, as previously described antibodies in the five system. A long incubation procedure (20-25 h) seemed to be optimal for granulocyte agglutination.
D000368:Aged; D000372:Agglutination Tests / Q000379:methods; D000373:Agglutinins / Q000276:immunology*; D000918:Antibody Specificity; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000276:immunology*; D001803:Blood Transfusion; D006098:Granulocytes / Q000276:immunology / Q000502:physiology; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D007518:Isoantibodies / Q000276:immunology; D007962:Leukocytes / Q000276:immunology; D008297:Male; D010949:Plasma; D011506:Proteins; D012128:Respiratory Distress Syndrome / Q000209:etiology*; D065227:Transfusion Reaction
D000373:Agglutinins; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D007141:Immunoglobulin Fc Fragments; D007518:Isoantibodies; D011506:Proteins; C100155:leukoagglutinins, leukocytes