[Stuporous state in an epileptic treated with sodium valproate. Diagnostic problems].
The authors report a case of stupor secondary to valproic acid, in a patient treated with this drug and phenobarbital for a complex partial form of epilepsy. The pathogeny of this rare complication is discussed. In this patient, a paradoxical epileptic reactivation is excluded, and the authors favor a metabolic mechanism: either hyperammoniemia or a perturbation in cerebral neuro-transmitter systems are proposed.
D000328:Adult; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D008297:Male; D014474:Unconsciousness / Q000139:chemically induced*; D014635:Valproic Acid / Q000009:adverse effects*
D014635:Valproic Acid
Etat stuporeux chez un épileptique traité par le valproate de sodium. Problèmes diagnostiques.