Multiple inducible cytochromes P-450 in yeast.
A form of cytochrome P-450 is produced in Saccharomyces cerevisiae during the logarithmic growth phase. This form is inhibited by metyrapone, tetrahydrofuran, and carbon oxide which are inhibitors of ethanol-inducible cytochromes P-450 of mammals. Addition of Na-phenobarbital to the 0.5% glucose liquid medium induced a form of cytochrome P-450 inhibited only by metyrapone. Thus, yeast possess multiple forms of cytochrome P-450 that are individually inducible.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis* / Q000235:genetics; D004790:Enzyme Induction; D007527:Isoenzymes / Q000096:biosynthesis* / Q000235:genetics; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*
D007527:Isoenzymes; D015112:4-Nitroquinoline-1-oxide; D003577:Cytochrome P-450 Enzyme System