Effect of disulfiram on function of the liver of rats with galactosamine-induced hepatitis.
This study was aimed to examine whether disulfiram (DS) may exacerbate the pre-existing liver damage induced by D-galactosamine (GalN) in rats. DS, 600 mg/kg, administered by gavage for 3 days caused an increase in asparagine aminotransferase (AspAT) and alkaline phosphatase (AP) and a decrease in cholinesterase (ChE) activity in the serum and decrease in AspAT and ChE activity in the liver. DS given to rats with GAlN-induced liver injury caused significant increase in alanine aminotransferase (A1AT) and bilirubin level in serum in comparison with rats with GalN-damaged liver but without DS treatment. In summary, DS exacerbates a damage of the liver of rats. This study supported the clinical observations showing enhanced liver damage in alcoholics treated with DS.
D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000503:physiopathology*; D002802:Cholinesterases / Q000378:metabolism; D004221:Disulfiram / Q000633:toxicity*; D005688:Galactosamine / Q000633:toxicity*; D006038:Glyoxylates / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012694:Serine / Q000378:metabolism; D000637:Transaminases / Q000378:metabolism
D006038:Glyoxylates; D012694:Serine; D005688:Galactosamine; D000637:Transaminases; D000410:Alanine Transaminase; C022636:serine-glyoxylate aminotransferase; D002802:Cholinesterases; D000469:Alkaline Phosphatase; D001663:Bilirubin; D004221:Disulfiram