title: [2-component inhibition of prostaglandin H synthetase by nonsteroidal anti-inflammatory preparations].
abstract: A combined effect on the irreversible inhibitor aspirin and fast reversible inhibitors ibuprofen, naproxen and sodium salicylate on prostaglandin-H-synthetase was studied on microsomal fractions from ram vesicular glands. The fast reversible inhibitors were shown to bind to prostaglandin-H-synthetase at the same site as aspirin and thereby to protect the enzyme against irreversible inactivation by aspirin.
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors; D007700:Kinetics; D008297:Male; D008861:Microsomes / Q000201:enzymology; D012669:Seminal Vesicles / Q000201:enzymology; D012756:Sheep
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors
vernacular_title: Dvukhkomponentnoe ingibirovanie prostaglandin-H-sintetazy nesteroidnymi protivovospalitel'nymi preparatami.