Expression of Pgp-1 (or Ly24) by subpopulations of mouse thymocytes and activated peripheral T lymphocytes.
The expression of Pgp-1 (Ly24) by subpopulations of thymocytes was investigated and a subpopulation of Lyt-2-/L3T4-/J11d- thymocytes was identified which contained significant numbers (80%) of Pgp-1+ cells. Among freshly isolated lymph node T cells but not cortisone-resistant thymocytes, Pgp-1 expression was heterogeneous. Stimulation of T lymphocytes with either concanavalin A or the combination of phorbol myristate acetate plus calcium ionophore resulted in increased Pgp-1 expression which was found to be regulated independently of DNA synthesis and interleukin 2 receptor expression. T cells in the cerebrospinal fluid exudate of mice infected with lymphocytic choriomeningitis virus were also found to be Pgp-1+.
D000818:Animals; D000954:Antigens, Surface / Q000096:biosynthesis*; D003208:Concanavalin A / Q000494:pharmacology; D004261:DNA Replication; D004987:Ethers / Q000494:pharmacology; D005260:Female; D015759:Ionomycin; D007700:Kinetics; D008198:Lymph Nodes / Q000166:cytology; D008213:Lymphocyte Activation / Q000187:drug effects; D008216:Lymphocytic Choriomeningitis / Q000134:cerebrospinal fluid / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D010641:Phenotype; D011971:Receptors, Immunologic / Q000096:biosynthesis; D015375:Receptors, Interleukin-2; D016201:Receptors, Lymphocyte Homing; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013950:Thymus Gland / Q000166:cytology*
D000954:Antigens, Surface; D004987:Ethers; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D016201:Receptors, Lymphocyte Homing; D003208:Concanavalin A; D015759:Ionomycin; D013755:Tetradecanoylphorbol Acetate