Effect of a radiographic contrast agent on renal function in the rat. Comparison with equiosmolar mannitol.
The renal effects of the radiographic contrast agent meglumine iothalamate (Conray; C) were evaluated in rats. C produced a 42% fall in glomerular filtration rate (p less than 0.05) and a 44% fall in effective renal plasma flow (p less than 0.05). The effects of C were blunted by both acute and chronic volume expansion. Equiosmolar mannitol produced similar hemodynamic responses as C. The fractional excretions of sodium and potassium were similar in rats given C or mannitol. The renal effects of C appear to be due to its hypertonicity. These effects may be modified by volume expansion.
D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D005069:Evaluation Studies as Topic; D007261:Infusions, Intra-Arterial; D007482:Iothalamate Meglumine / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D007678:Kidney Glomerulus / Q000378:metabolism; D008353:Mannitol / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine
D003287:Contrast Media; D008353:Mannitol; D012964:Sodium; D007482:Iothalamate Meglumine