Urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)-nitrosamine in an analbuminemic congenic strain of rats with an ACI genetic background.
An analbuminemic congenic strain of rats originating from ACI (ACI-alb) rats was established. The rats were found to be highly susceptible to induction of urinary bladder cancer by N-butyl-N-(4-hydroxy-butyl)nitrosamine. Bladder cancers were observed in all male ACI-alb and normal ACI rats treated with the compound, but the average weight of the bladder including tumors was more in ACI-alb rats than in ACI rats (0.63 +/- 0.24 g and 0.18 +/- 0.05 g, respectively; ratio, 3.5:1).
D000818:Animals; D002085:Butylhydroxybutylnitrosamine; D008297:Male; D051381:Rats; D011912:Rats, Inbred ACI; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D012709:Serum Albumin / Q000172:deficiency*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
D012709:Serum Albumin; D002085:Butylhydroxybutylnitrosamine