title: Valproic acid loading during intensive monitoring.
abstract: Of 35 patients who had generalized tonic-clonic seizures during antiepileptic drug therapy withdrawal, "loading" with valproic acid was effective in limiting these seizures in 32 patients. A loading dose of approximately 12.5 mg/kg was used. This dose resulted in valproic acid levels between 284 and 458 mumol/L (41 and 66 mg/L) 1.5 hours after "loading" in six of the eight patients in whom serum concentrations were measured.
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage*; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D014635:Valproic Acid / Q000097:blood / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid