Antitumor effect of human necrosis factor on human hepatoma cells PLC/PRF/5.
The antitumor activity of natural human tumor necrosis factor (TNF) on a human hepatoma cell line PLC/PRF/5 was studied in vitro. TNF produced by the LuKII human lymphoblastoid cell line showed a cytostatic effect on the hepatoma cells, whereas the growth of non-tumorigenic Chang liver cells was little affected. The combined effects of TNF and interferon-gamma (IFN-gamma) were additive on the PLC/PRF/5 cells as shown by statistical analyses. The same combination showed synergistic effects on a human breast cancer cell line BT-20, which was highly sensitive to TNF. These data may provide some informations concerning the use of TNF in the treatment of hepatoma.
D000818:Animals; D000970:Antineoplastic Agents; D002453:Cell Cycle / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D004357:Drug Synergism; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy*; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy; D014409:Tumor Necrosis Factor-alpha
D000970:Antineoplastic Agents; D006023:Glycoproteins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma