Intravitreal trifluorothymidine and retinal toxicity.
Intraocular trifluorothymidine was administered to one group of albino rabbits as an intravitreal injection, and to a second group of albino rabbits in the infusion solution during pars plana vitrectomy. The eyes of both populations were evaluated with preoperative and postoperative indirect ophthalmoscopy, electroretinography, and histologic examination. From these data, it was determined that an intravitreal injection of 200 micrograms/0.1 ml and a vitrectomy solution containing a concentration of 60 micrograms/ml trifluorothymidine were nontoxic to the rabbit eye.
D000818:Animals; D010786:Photoreceptor Cells / Q000187:drug effects / Q000473:pathology; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D013936:Thymidine / Q000031:analogs & derivatives*; D014271:Trifluridine / Q000633:toxicity*
D014271:Trifluridine; D013936:Thymidine