Antitumor activity of some bacterial proteases: eradication of solid tumors in mice by intratumor injection.
A protease isolated from the culture filtrate of a Gram-negative bacteria, Serratia marcescens kums 3958, showed very potent antitumor activity when injected into Meth-A or RL male 1 tumors in BALB/c mice at 30 micrograms per tumor or more. This and certain other proteases, which are resistant to many protease inhibitors in plasma, appear to be new candidate drugs for regional treatment of solid tumors.
D000818:Animals; D001201:Ascites / Q000188:drug therapy; D051379:Mice; D016685:Mitomycin; D008937:Mitomycins / Q000627:therapeutic use; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D011480:Protease Inhibitors / Q000494:pharmacology; D012706:Serratia marcescens / Q000201:enzymology*
D008937:Mitomycins; D011480:Protease Inhibitors; D016685:Mitomycin; D010447:Peptide Hydrolases