Food deprivation and stimulant self-administration in rats: differences between cocaine and d-amphetamine.
The effects of food deprivation (24 h) on response rates of rats self-administering d-amphetamine and cocaine were compared. Food deprivation clearly increased rates of responding for both drugs but did so to a significantly greater extent for cocaine than for d-amphetamine. Consistent with other findings, the results suggest that the neural substrates underlying cocaine and d-amphetamine reinforcement are not identical.
D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005508:Food Deprivation / Q000502:physiology*; D007262:Infusions, Intravenous; D051381:Rats; D012646:Self Administration
D003042:Cocaine; D003913:Dextroamphetamine