Interstitial deletion of the short arm of chromosome 6 as a new cytogenetic marker of T-cell lymphoma.
Three patients with malignant lymphoma, two of T-cell type and the other probably also of T-cell type, had an interstitial deletion of the short arm of chromosome 6, del (6)(p21p23), in common in their lymphoma cells. These findings suggest that this new type of chromosome deletion may be a specific marker for T-cell lymphoma and may play an important role in the lymphomagenesis and the expression of the T-cell phenotype.
D000293:Adolescent; D000368:Aged; D002872:Chromosome Deletion; D002906:Chromosomes, Human, 6-12 and X; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008223:Lymphoma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013601:T-Lymphocytes / Q000648:ultrastructure
D005819:Genetic Markers