title: Changing the identity of a transfer RNA.
abstract: A leucine transfer RNA has been transformed into a serine transfer RNA by changing 12 nucleotides. This result indicates that a limited set of residues determine tRNA identity.
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D000926:Anticodon; D001483:Base Sequence; D003062:Codon; D004926:Escherichia coli / Q000235:genetics; D007930:Leucine; D009690:Nucleic Acid Conformation; D014176:Protein Biosynthesis; D012343:RNA, Transfer / Q000235:genetics* / Q000378:metabolism; D012694:Serine; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D013489:Suppression, Genetic
chemical_list: D000926:Anticodon; D003062:Codon; D012694:Serine; D012343:RNA, Transfer; D000604:Amino Acyl-tRNA Synthetases; D007930:Leucine