Effect of antioxidants on mutagenesis induced by DMBA in human cells.
The effect of vitamin A palmitate (VAP), vitamin A acetate (VAA), 2,3-tert-butyl-4-hydroxyanisole, and 2,6-di-tert-butyl-p-cresol (BHT) on mutagenesis induced by 7,12-dime-thylbenz[a]anthracene (DMBA) was examined in a human epithelial-like cell line. Cultures were exposed to DMBA with or without the antioxidant compound, and mutation frequencies were determined by selection against diphtheria toxin. A clear inhibition of mutagenesis was observed particularly with VAA and BHT.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000975:Antioxidants / Q000494:pharmacology*; D002460:Cell Line; D004224:Diterpenes; D006801:Humans; D009154:Mutation / Q000187:drug effects*; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives / Q000494:pharmacology
D000975:Antioxidants; D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; C009166:retinol acetate; D015127:9,10-Dimethyl-1,2-benzanthracene