Fish oil in angina pectoris.
The effect of 12 weeks supplementation with fish oil on the number of anginal attacks and consumption of glyceryltrinitrate in 36 patients with stable angina pectoris was evaluated in a clinically controlled trial using a vegetable oil as placebo. Fish oil caused a decrease in frequency of angina, but was not significantly superior to placebo. However, due to the small sample size and a high spontaneous variation in number of anginal attacks, a risk of up to 50% of overlooking a 30% reduction in anginal attacks could be estimated. A significant inhibition of the epinephrine-induced platelet aggregation and a significant increase in intraplatelet cyclic AMP were induced by fish oil.
D000787:Angina Pectoris / Q000188:drug therapy*; D001792:Blood Platelets / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D005395:Fish Oils / Q000627:therapeutic use*; D006801:Humans; D005996:Nitroglycerin / Q000627:therapeutic use; D010979:Platelet Function Tests
D005395:Fish Oils; D005996:Nitroglycerin