Localization of talin in skeletal and cardiac muscles.
Antibodies to talin and vinculin were used for localization of these proteins in skeletal and cardiac muscles by the indirect immunofluorescence method. We have found that talin is localized in intercalated discs of cardiac muscle and in costameres of skeletal and cardiac muscles. It is suggested that in striated muscles talin and vinculin play an important role in interactions between actin filaments and membranes.
D000818:Animals; D002645:Chickens; D003598:Cytoskeletal Proteins / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D008565:Membrane Proteins / Q000032:analysis*; D009124:Muscle Proteins / Q000032:analysis; D009132:Muscles / Q000166:cytology*; D009206:Myocardium / Q000166:cytology*; D016608:Talin; D016596:Vinculin
D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D009124:Muscle Proteins; D016608:Talin; D016596:Vinculin