Testicular follicle stimulating hormone receptors and effectiveness of human menopausal gonadotrophin-human chorionic gonadotrophin treatment in infertile men.
In order to investigate the relationship between testicular FSH receptors and the effectiveness of hMG-hCG treatment in idiopathic male infertility, 36 infertile men were examined. None of the 13 patients without detectable testicular high affinity FSH receptors showed any increase in motile sperm count after the hMG-hCG treatment, whereas 11 of the 23 patients with FSH receptors responded to the treatment. In patients with FSH receptors, patients with a middle or high Johnsen's score count responded more than those with a low score count did. From the above results, it seems that both the presence or absence of testicular FSH receptors and the histological appearance of spermatogenesis predict responsiveness to hMG-hCG treatment in infertile men.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008596:Menotropins / Q000627:therapeutic use*; D008875:Middle Aged; D011962:Receptors, FSH / Q000032:analysis*; D013737:Testis / Q000032:analysis*
D006063:Chorionic Gonadotropin; D011962:Receptors, FSH; D008596:Menotropins