title: Empirical paternity exclusion rates.
abstract: We have developed an empirical method of estimating paternity exclusion rates for any genetic system by counting exclusions among fictitious "nonfather" paternity cases generated from true paternity disputes. Especially for multiallele multiloci systems, this technique has advantages over traditional formulae methods in that it replaces tedious (and, in some cases, impossible) computations with simple data file manipulations, and it avoids introducing quantities such as gametic disequilibrium and recombination fraction that are difficult to measure. Exclusion rates for standard and one-parent paternity cases are given for three racial groups (Caucasians, blacks, and Hispanics) in four genetic systems (HLA, ABO, MNSs, and Rh). Beside the method, of interest are our findings of higher HLA exclusion rates (93.25% for Caucasians, 94.62% for blacks, and 95.82% for Hispanics) compared with rates previously reported and high combined exclusion rates (89.59% for Caucasians, 91.65% for blacks, and 92.54% for Hispanics) in one-parent paternity cases.
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics; D000483:Alleles; D044383:Black People; D001789:Blood Group Antigens / Q000235:genetics*; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D010334:Paternity; D012204:Rh-Hr Blood-Group System / Q000235:genetics; D044465:White People
chemical_list: D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D006680:HLA Antigens; D012204:Rh-Hr Blood-Group System