[Effects of acute or chronic administration of desmethylimipramine on the local level of methionine incorporation in cerebral proteins in freely moving rats].
Incorporation of methionine into brain proteins has been measured by quantitative autoradiography after desmethylimipramine administration in rats. Acute treatment decreased protein synthesis in three regions: hippocampus, hypothalamus and habenula. After chronic treatment the decrease extended to four other regions: substantia nigra, raphe dorsalis, trigeminal nerve and hypophysis. An opposite effect was observed in the retrosplenial cortex.
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D003891:Desipramine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008715:Methionine / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D011506:Proteins; D008715:Methionine; D003891:Desipramine
Effets d'une administration aigüe ou chronique de desméthylimipramine sur les taux locaux d'incorporation de méthionine dans les protéines cérébrales chez le rat libre de se mouvoir.