Effects of pimozide on sucrose consumption and preference.
The effects of pimozide on sucrose intake were examined, in a two-bottle preference test (sucrose versus water), and in single-bottle tests at five different sucrose concentrations. In the two-bottle test, pimozide dose dependently decreased sucrose intake but increased water intake. In the single-bottle test pimozide decreased sucrose intake at low concentrations but had no effect at high concentrations. The results support a role for dopamine in mediating the rewarding effect of sucrose.
D000818:Animals; D002755:Choice Behavior / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects; D008297:Male; D010868:Pimozide / Q000494:pharmacology*; D051381:Rats; D013395:Sucrose / Q000494:pharmacology*
D010868:Pimozide; D013395:Sucrose