title: Uromodulin: an immunoregulatory glycoprotein isolated from pregnancy urine that binds to and regulates the activity of interleukin 1.
abstract: Uromodulin is an 85 kilodalton glycoprotein originally isolated from human pregnancy which has been shown to inhibit antigen specific T cell responses to recall antigens such as tetanus toxoid. We have also found that uromodulin is a high affinity ligand for interleukin 1 and is able to regulate the activity of interleukin 1 in vitro. Finally, we present data that free interleukin 2 receptor can be found in human pregnancy urine. We propose that a number of immunoregulatory phenomena associated with pregnancy are due to molecules able to specifically regulate interleukin 1 and interleukin 2.
mesh_terms: D000276:Adjuvants, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism* / Q000502:physiology; D008213:Lymphocyte Activation / Q000187:drug effects; D008970:Molecular Weight; D009088:Mucoproteins / Q000302:isolation & purification / Q000652:urine; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000276:immunology / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology* / Q000652:urine; D011485:Protein Binding; D011971:Receptors, Immunologic / Q000276:immunology / Q000652:urine; D015375:Receptors, Interleukin-2; D058949:Uromodulin
chemical_list: D000276:Adjuvants, Immunologic; D007375:Interleukin-1; D009088:Mucoproteins; D011257:Pregnancy Proteins; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; C548612:UMOD protein, human; D058949:Uromodulin