Increased collagen synthesis of bone marrow fibroblasts by materials released from platelets of chronic granulocytic leukemia and polycythemia vera.
Collagen synthesis stimulated by materials released from platelets (MRFP) of patients with chronic granulocytic leukemia (CGL) and polycythemia vera (PV) was measured in human bone marrow fibroblasts derived from normal individuals. The MRFP of patients with CGL and PV stimulated normal fibroblast collagen synthesis significantly compared to the response from normal MRFP. Platelets derived from patients with CGL and PV may have some factors that dramatically stimulate collagen synthesis which is relevant to the frequently observed myelofibrosis in these diseases.
D000328:Adult; D001792:Blood Platelets / Q000032:analysis*; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism*; D002457:Cell Extracts / Q000494:pharmacology*; D003094:Collagen / Q000096:biosynthesis*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000097:blood*; D013997:Time Factors; D014020:Tissue Extracts / Q000494:pharmacology*
D002457:Cell Extracts; D014020:Tissue Extracts; D003094:Collagen