Patterns of gene expression during plasmacytoid differentiation of chronic lymphocytic leukaemia cells.
Chronic lymphocytic leukaemia (CLL) cells may be induced to undergo plasmacytoid differentiation in vitro in response to 12-O-tetradecanoyl phorbol acetate (TPA). We show here that plasmacytoid differentiation and the accompanying accumulation of Cmu immunoglobulin mRNA are preceded by a rapid transient increase in the expression of the proto-oncogenes, c-myc and c-fos. In terminally differentiated cells the level of c-fos mRNA returned to the original basal level whilst c-myc expression remained appreciably higher than in undifferentiated CLL cells. These data support a possible role for c-fos and c-myc in the programmed chain of events that occur during terminal differentiation of B-lymphocytes.
D001402:B-Lymphocytes / Q000473:pathology*; D002454:Cell Differentiation / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis / Q000235:genetics; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000473:pathology*; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D010950:Plasma Cells / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis* / Q000235:genetics; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D007136:Immunoglobulins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D013755:Tetradecanoylphorbol Acetate