Haloperidol facilitates memory retrieval in the rat.
Rats were trained in a complex maze task for food reward. After a 25-day retention interval, they made more errors than at the last training trials. This forgetting was alleviated by pretest treatment with haloperidol. The same dose of haloperidol had no effect on acquisition or performance when injected during training. The results were replicated, but smaller doses were found to be inactive. The possibility that the effect might be mediated through the noradrenergic system is considered.
D000320:Adrenergic Fibers / Q000187:drug effects; D000818:Animals; D006220:Haloperidol / Q000494:pharmacology*; D008125:Locus Coeruleus / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D009638:Norepinephrine / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013681:Tegmentum Mesencephali / Q000187:drug effects
D006220:Haloperidol; D009638:Norepinephrine