title: Serovars, auxotypes, and plasmid contents of PPNG strains from outbreak in Amsterdam.
abstract: The first outbreak of penicillinase producing strains of Neisseria gonorrhoeae (PPNG) in Amsterdam in 1981-2 was caused mainly by African strains carrying the 24 megadalton transfer plasmid (Afr+) that were non-requiring (NR) and inhibited by phenylalanine (pheni), but African strains without the transfer plasmid (Afr-) that were NRpheni and Afr+ NR strains were also found. Serological classification, using two monoclonal antibody systems, showed that three main serovars (Ae/Av, Aedih/Arst, and Bacejk/Brpyust) could be distinguished in these PPNG strains, which indicated exchanges of plasmids in these serovars. The serovar Ae/Av predominated in the Afr+ and Bacejk/Brpyust in the Afr- strains.
mesh_terms: D004196:Disease Outbreaks; D006069:Gonorrhea / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000145:classification* / Q000201:enzymology / Q000235:genetics; D009426:Netherlands; D010405:Penicillinase / Q000032:analysis*; D010957:Plasmids; D012703:Serotyping
chemical_list: D010405:Penicillinase