title: The use of lidocaine to reduce the pain of myochrysine injections for children with juvenile rheumatoid arthritis.
abstract: Myochrysine (gold sodium thiomalate, GSTM) injections are the therapy of choice for children with refractory juvenile rheumatoid arthritis. In this single blinded study 8 children receiving GSTM were asked to rate their discomfort after a total of 185 injections of GSTM to which were added in random fashion either 0, 0.1, or 0.25 ml of 1% lidocaine. The addition of 0.1 ml of lidocaine was associated with a reduction of the mean complaint of pain on an ordinal pain score of 1-10 from 4.32 for injections containing no lidocaine to 2.54 for injections containing 0.1 ml (p less than .01). Addition of 0.25 ml of lidocaine did not provide a significant increase in pain reduction (p greater than .05).
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004338:Drug Combinations; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007273:Injections, Intramuscular; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control
chemical_list: D004338:Drug Combinations; D006052:Gold Sodium Thiomalate; D008012:Lidocaine