Induction of ovarian activity by pulsatile infusion of LHRH in women with lactational amenorrhoea.
Four fully breast-feeding women at 6 weeks post partum were injected with LHRH (0.1 microgram/kg) every 94 min by pulsatile infusion pump. While follicular development occurred in all women, and evidence of luteinization was apparent in three out of four, normal ovulation and luteal function did not occur. This suggests that a simple disturbance in the pulsatile pattern of LHRH secretion may not, in itself, be enough to explain the suppression of ovarian activity during lactation.
D000328:Adult; D000568:Amenorrhea / Q000503:physiopathology* / Q000652:urine; D001942:Breast Feeding; D003404:Creatinine / Q000652:urine; D004967:Estrogens / Q000652:urine; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D007263:Infusions, Parenteral; D007986:Luteinizing Hormone / Q000378:metabolism; D006080:Ovarian Follicle / Q000187:drug effects; D010053:Ovary / Q000502:physiology*; D011247:Pregnancy; D011276:Pregnanediol / Q000652:urine; D011388:Prolactin / Q000378:metabolism
D004967:Estrogens; D007987:Gonadotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003404:Creatinine; D011276:Pregnanediol