Carcass and organ composition of rats fed high fat total parenteral nutrition.
Fat-based total parenteral nutrition (TPN) has been shown to maintain the host nutritionally equivalent to carbohydrate-based TPN in a rat model; however, data on body composition have not been obtained. This study compared the effects of a lipid-based TPN regimen to those of an isocaloric glucose-based regimen and an oral diet on the composition of the carcass and organs of tumor- and nontumor-bearing rats. Sprague-Dawley rats implanted with the Walker 256 carcinosarcoma were randomly assigned to either diet A, a glucose-based TPN regimen; B, a lipid-based TPN regimen; or C, a purified oral diet. Tumor-bearing rats infused with diet B had less protein and more fat in their carcasses than those in the other dietary groups. Organs of nontumor- and tumor-bearing rats fed diet B contained less protein and more fat and triglycerides than rats fed either diet A or C. Survival index and hematocrit values were lowest in rats infused with the parenteral lipid diet. These findings indicate an abnormal pathological response to a TPN diet formulated to deliver 67% of nonprotein kilocalories as lipid.
D000818:Animals; D001823:Body Composition; D002279:Carcinoma 256, Walker / Q000032:analysis / Q000097:blood / Q000628:therapy; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects; D005947:Glucose / Q000008:administration & dosage; D006949:Hyperlipidemias / Q000209:etiology; D008297:Male; D009753:Nutritive Value; D010289:Parenteral Nutrition, Total; D051381:Rats; D011919:Rats, Inbred Strains
D005217:Fat Emulsions, Intravenous; D005947:Glucose