Growth of Clostridium difficile and production of toxins A and B in complex and defined media.
The ability of several strains of Clostridium difficile to grow and to produce toxins A and B in complex and defined culture media has been studied with special reference to the amino-acid composition of the medium. The production of these toxins varied with the strain used and with the composition of the growth medium. Toxin A production was not inextricably linked to production of toxin B since conditions were found in which only one or other toxin was produced.
D000596:Amino Acids / Q000502:physiology; D001426:Bacterial Proteins; D001427:Bacterial Toxins / Q000096:biosynthesis*; D003013:Clostridium / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D003470:Culture Media / Q000494:pharmacology; D004768:Enterotoxins
D000596:Amino Acids; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D003470:Culture Media; D004768:Enterotoxins; C041348:tcdA protein, Clostridium difficile; C031815:toxB protein, Clostridium difficile