Immunochemical studies on lactate dehydrogenase A subunit deficiencies.
In lactate dehydrogenase (LDH) A subunit deficiency, is there not only a lack of activity but also a lack of subunit production? We demonstrated three remarkable points to answer this question: There are no proteins that immunologically react with anti-A subunits. There are no heterotetramers that react with anti-B subunits. B subunits seem to be genetically produced at normal level, and all of them form only one isoenzyme, LDH-B4. From these points, we concluded that there is a complete lack of A subunit production or production of incomplete A subunits that can neither react with anti-A subunits nor form heterotetramers.
D006801:Humans; D005779:Immunodiffusion; D007163:Immunosorbent Techniques; D007770:L-Lactate Dehydrogenase / Q000172:deficiency* / Q000276:immunology; D046911:Macromolecular Substances
D046911:Macromolecular Substances; D007770:L-Lactate Dehydrogenase