Thrombocytopenia and vomiting due to difluoromethylornithine.
A 32-year-old Haitian male with acquired immunodeficiency syndrome presented with complications of Isospora belli enteritis. Therapy with the investigational drug difluoromethylornithine was initiated. Severe thrombocytopenia, nausea, and vomiting developed during intravenous drug therapy and recurred upon rechallenge with low-dose oral difluoromethylornithine. Therapy was discontinued because of these severe adverse effects.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D003048:Coccidiosis / Q000188:drug therapy / Q000209:etiology; D000518:Eflornithine / Q000009:adverse effects* / Q000627:therapeutic use; D004751:Enteritis / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D013921:Thrombocytopenia / Q000139:chemically induced*; D014839:Vomiting / Q000139:chemically induced*
D000518:Eflornithine