Post-transfusion non-A, non-B hepatitis after cardiac surgery. Prospective analysis of donor blood anti-HBc antibody as a predictive indicator of the occurrence of non-A, non-B hepatitis in recipients.
We prospectively studied the incidence of post-transfusion non-A, non-B hepatitis in 64 cardiac surgery patients: 4 (6.25%) developed non-A, non-B hepatitis after an incubation period of 4-10 weeks. Units of blood products from donors seropositive for antibody to hepatitis B core antigen (anti-HBc) were not associated with a greater risk of non-A, non-B hepatitis in recipients than units from seronegative donors. Our data indicate that donor blood anti-HBc testing is of no value as a screening method to reduce the incidence of post-transfusion non-A, non-B hepatitis.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D006348:Cardiac Surgical Procedures; D005260:Female; D005500:Follow-Up Studies; D006512:Hepatitis B Core Antigens / Q000032:analysis* / Q000276:immunology; D006526:Hepatitis C / Q000097:blood / Q000209:etiology / Q000635:transmission*; D006525:Hepatitis, Viral, Human / Q000635:transmission*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D065227:Transfusion Reaction
D000914:Antibodies, Viral; D006512:Hepatitis B Core Antigens