Pharmacologic evaluation of standard and controlled-release disopyramide.
Controlled-release disopyramide offers many potential advantages over the standard formulation for improved patient compliance, possible reduction of concentration-related adverse effects, and predictability of pharmacologic effect. The pharmacology of disopyramide, potential advantages and disadvantages of the use of sustained- (or controlled-)release formulations of drugs, and the preliminary finding of our use of controlled-release disopyramide are described. Controlled-release disopyramide is a promising addition to the antiarrhythmic formulary that may increase the clinical utility of disopyramide.
D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000378:metabolism; D003692:Delayed-Action Preparations; D004206:Disopyramide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D004341:Drug Evaluation; D006801:Humans
D000889:Anti-Arrhythmia Agents; D003692:Delayed-Action Preparations; D004206:Disopyramide