A suspected case of late-onset sodium-valproate-induced hepatic failure.
A 15-year-old boy was under anti-epileptic medication (diphenylhydantoine, phenobarbital and Na valproate) for more than five years. He was admitted in cerebral coma and died after 24 hours. The histological findings suggest a valproate induced liver toxicity. This long interval between start of treatment and a possibly related hepatic failure has not been described.
D000293:Adolescent; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy*; D006501:Hepatic Encephalopathy / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
D014635:Valproic Acid