title: Generalized hypersensitivity reaction to intravesical thiotepa and doxorubicin.
abstract: We describe an unusual case of pruritus after intravesical thiotepa, and diaphoresis, shortness of breath, chills and pruritus following intravesical doxorubicin therapy. Such generalized allergic reactions occur uncommonly after bladder instillation of thiotepa or doxorubicin.
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D011537:Pruritus / Q000139:chemically induced; D013546:Sweating / Q000187:drug effects; D013852:Thiotepa / Q000008:administration & dosage / Q000009:adverse effects*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy; D014581:Urticaria / Q000139:chemically induced
chemical_list: D004317:Doxorubicin; D013852:Thiotepa