Ultrastructural demonstration of nerve endings containing a substance related to growth hormone-releasing factor in the guinea-pig paraventricular nucleus.
By means of a preembedding immuno-electron-microscopic technique, a large number of nerve endings containing a substance related to human growth hormone-releasing factor (hGRF) have been demonstrated in the paraventricular nucleus of the guinea pig. They made synaptic contacts primarily with dendritic shafts: 80% of these contacts were symmetrical. The immunoprecipitate was located mainly in large granules and around small clear vesicles. These findings suggest that a peptide related to hGRF may play a role in neural communication in the paraventricular nucleus.
D000818:Animals; D003712:Dendrites / Q000648:ultrastructure; D013007:Growth Hormone-Releasing Hormone / Q000032:analysis*; D006168:Guinea Pigs; D007106:Immune Sera; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000648:ultrastructure*; D010286:Paraventricular Hypothalamic Nucleus / Q000648:ultrastructure*; D013569:Synapses / Q000648:ultrastructure
D007106:Immune Sera; D013007:Growth Hormone-Releasing Hormone