Evaluation of LD50 of some polyaminocarboxylic acids used as chelating drugs in metal intoxication.
The LD50 of the following metal-binding chelating drugs, EDTA, diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetriacetic acid (HEDTA), cyclohexanediaminotetraacetic acid (CDTA) and triethylenetetraminehexaacetic acid (TTHA) was evaluated in terms of mortality in rats after intraperitoneal administration and was found to be in the order: CDTA greater than EDTA greater than DTPA greater than TTHA greater than HEDTA. A possible correlation between the toxicity and molecular structure of the compounds is discussed.
D000818:Animals; D002614:Chelating Agents / Q000633:toxicity*; D004492:Edetic Acid / Q000031:analogs & derivatives / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D008670:Metals / Q000506:poisoning*; D004369:Pentetic Acid / Q000633:toxicity; D051381:Rats; D013329:Structure-Activity Relationship
D002614:Chelating Agents; D008670:Metals; C005390:CDTA; D004369:Pentetic Acid; C026059:triethylenetetraminehexaacetic acid; D004492:Edetic Acid; C026060:N-(hydroxyethyl)ethylenediaminetriacetic acid