Reversible valproate fulminant hepatic failure.
Valproate fulminant hepatotoxicity, usually fatal, is believed to be idiosyncratic and metabolic without an immunologic basis. There are no previous reports of a hypersensitivity reaction among numerous cases of fatal valproate fulminant hepatitis. Little is known about the electron microscopical features of valproate hepatitis. We report a case of reversible fulminant hepatitis attributable to valproate with clinical and histological characteristics of a hypersensitivity reaction. Electron microscopical findings included microvesicular steatosis with normal-appearing mitochondria.
D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D002648:Child; D004342:Drug Hypersensitivity / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008099:Liver / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D014635:Valproic Acid / Q000009:adverse effects*
D014635:Valproic Acid