title: Right-heart echocontrast in the anesthetized dog after i.v. administration of a new standardized sonographic contrast agent. 3rd communication: comparison of various contrast agents employed in contrast echocardiography.
abstract: Right-ventricular contrast provided by the new standardized sonographic contrast agent SH U 454, which consists of pure galactose microparticles, with 300 mg microparticles/ml and by 5 other currently employed ultrasonic contrast media was examined by 2 D echocardiography in 10 anesthetized female beagle dogs (6.8-12.7 kg) following i.v. administration. With a 5-min interval between injections each animal was given 3 injections of 2 ml of each formulation in random order using an injection speed of approximately 2 ml/s. The echocardiographic investigation was recorded on videotape and the contrast assessed blind using a visual score system (rating 0-5) by two investigators working independently and also by a videodensitometer. Only SH U 454 caused an intense, homogeneous and reproducible opacification of the right heart chambers. By comparison with other formulations for right-heart echocontrast, SH U 454 was significantly superior (p less than 0.05) in every parameter assessed.
mesh_terms: D000818:Animals; D002245:Carbon Dioxide; D003287:Contrast Media; D004285:Dogs; D004452:Echocardiography; D005260:Female; D006861:Hydrogen Peroxide; D007208:Indocyanine Green; D007275:Injections, Intravenous; D011097:Polygeline; D011134:Polysaccharides / Q000008:administration & dosage
chemical_list: D003287:Contrast Media; D011134:Polysaccharides; D002245:Carbon Dioxide; D011097:Polygeline; C040642:SHU 454; D006861:Hydrogen Peroxide; D007208:Indocyanine Green