[Dialysis encephalopathy and aluminum poisoning? Correlated clinical, pathologic-anatomic and spectrometric findings].
A case of severe dialysis encephalopathy is reported, in which the autopsy finding of an extensive spongiform change in areas of the cortex directly corresponded to high aluminium-concentration in these areas, supporting the theory of an aetiological role for aluminium. A therapeutic approach combining low aluminium intake and removal of aluminium by a chelating agent (desferrioxamine) is promising, but more precise guidelines are needed.
D000535:Aluminum / Q000097:blood / Q000378:metabolism / Q000506:poisoning*; D001921:Brain / Q000473:pathology; D001925:Brain Damage, Chronic / Q000473:pathology*; D004830:Epilepsy, Tonic-Clonic / Q000473:pathology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000473:pathology; D008875:Middle Aged; D009474:Neurons / Q000473:pathology; D006435:Renal Dialysis; D013054:Spectrophotometry, Atomic; D019966:Substance-Related Disorders / Q000473:pathology*
D000535:Aluminum
Dialyseencephalopathie und Aluminiumtoxikation? Klinisch, pathologisch-anatomisch und spektrometrisch korrelierte Befunde.