title: Circadian variations of the absolute eosinophil count and serum histaminase activity in tropical pulmonary eosinophilia.
abstract: Nine healthy volunteers and 25 tropical pulmonary eosinophilia (TPE) patients were used to study circadian variations of absolute eosinophil count (AEC) and serum histaminase activity (SHA). A marked circadian variation was found in AEC for healthy volunteers and TPE patients with the worst symptoms in the late evening and morning hours only; no rhythm could be detected in SHA for healthy subjects. However, TPE patients with worst symptoms in the late evening hours did exhibit a significant rhythm in SHA. Increased SHA in all TPE patients at all time-points of the 24 hour day-night cycle, irrespective of the worsening hours of symptoms in comparison to healthy controls, could be due to increased histamine production in such situations.
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D002940:Circadian Rhythm; D004804:Eosinophils; D006801:Humans; D007958:Leukocyte Count; D011657:Pulmonary Eosinophilia / Q000097:blood*
chemical_list: D006631:Amine Oxidase (Copper-Containing)