The phylogenetic distribution of the liver protein F antigen.
F antigen is a liver protein of unknown function previously thought to be confined to class Mammalia. Using a recently developed radioimmunoassay, we show that F antigen can also be found in classes Aves, Reptilia, Amphibia and Osteichthyes. Ouchterlony gel diffusion (using murine antibodies) gave lines of identity or partial identity between mammalian F antigens, a line of identity between avian and reptilian F antigens (each showing partial identity to mammalian) and no precipitation with fish or amphibian F antigens. All immunopurified F antigens have molecular weights of 40,000-45,000.
D000818:Animals; D002645:Chickens; D003429:Cross Reactions; D004591:Electrophoresis, Polyacrylamide Gel; D005399:Fishes; D006168:Guinea Pigs; D005779:Immunodiffusion; D007519:Isoantigens / Q000032:analysis* / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D008099:Liver / Q000276:immunology*; D051379:Mice; D008970:Molecular Weight; D010802:Phylogeny; D011817:Rabbits; D011863:Radioimmunoassay / Q000379:methods; D051381:Rats
D007519:Isoantigens; C030497:liver specific F antigen