Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency.
Intraperitoneal administration of group A streptococcal cell walls to Lewis rats induces a chronic arthritis, whereas the Fischer strain is resistant to the development of the lesion. Spleen cells from cell wall-treated rats (Lewis and Fischer) are deficient in the synthesis of IL-2. Using an mAb directed against the rat IL-2-R, the present studies indicate that the expression of IL-2-R on spleens of cell wall-treated rats is normal. However, the addition of exogenous IL-2 to spleen cells cultured with Con A does not stimulate the mitogenic response.
D000818:Animals; D001168:Arthritis / Q000209:etiology / Q000276:immunology; D002473:Cell Wall / Q000276:immunology; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D007153:Immunologic Deficiency Syndromes / Q000209:etiology / Q000276:immunology*; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000378:metabolism / Q000502:physiology; D008213:Lymphocyte Activation; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D011971:Receptors, Immunologic / Q000032:analysis; D015375:Receptors, Interleukin-2; D013154:Spleen; D013297:Streptococcus pyogenes / Q000276:immunology*
D007376:Interleukin-2; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D003208:Concanavalin A