title: A reaction between captopril (a high blood pressure drug) and gold(I)-thiomalate.
abstract: A reaction of gold(I) thiomalates [Au(tm)], "Myocrisin" (an antiarthritic drug), with captopril (a high blood pressure drug) was carried out in aqueous solution at pH 7.20 using 13C NMR spectroscopy. Captopril, which exists in the cis (c) and trans (t) isomer forms, binds strongly with gold(I), ejecting thiomalate (Htm) as free ligand into solution.
mesh_terms: D002216:Captopril; D055598:Chemical Phenomena; D002621:Chemistry; D006052:Gold Sodium Thiomalate; D006863:Hydrogen-Ion Concentration; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy
chemical_list: D006052:Gold Sodium Thiomalate; D002216:Captopril