[Amphotericin B and flucytosine therapy of Aspergillus pneumonia and acute renal failure].
Kidney failure and pneumonia by Aspergillus flavus and A. fumigatus were found in a 56-year-old woman who had received antibiotic and corticoid treatment to control high fever. Her bloody tracheal secretion was a suspension of granule-like spore-free colonies of both Aspergillus species. Hemorrhages in mucous membranes and skin suggested a hematogenous dissemination of the fungi. Aspergillus spores in the soil of ornamental plants were assumed to be responsible for the inhalatory infection. The kidney function normalized rapidly under treatment by amphotericin B plus flucytosine and hemodialysis performed eight times. After 29 days of antimycotic treatment (amphotericin B 463 mg, flucytosine 150 g), besides normalization of the kidney function, healing of the pneumonia and bleeding from skin and mucal membranes took place. One and a half years later kidney function and blood parameters were found to be normal. In cases of Aspergillus pneumonia and kidney failure, a combined treatment by hemodialysis and amphotericin B plus flucytosine is recommended. In addition, there is discussion of the general importance of uremia and its influence on the mycotic infection.
D058186:Acute Kidney Injury / Q000188:drug therapy*; D000666:Amphotericin B / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy*; D001231:Aspergillus flavus / Q000187:drug effects; D001232:Aspergillus fumigatus / Q000187:drug effects; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D008875:Middle Aged; D006435:Renal Dialysis
D000666:Amphotericin B; D005437:Flucytosine
Amphotericin B und Flucytosin-Therapie bei Aspergillus-Pneumonie und akutem Nierenversagen. Doppelinfektion mit A. flavus und A. fumigatus.