title: The history of diclofenac.
abstract: The purpose in developing diclofenac sodium was to synthesize a nonsteroidal anti-inflammatory drug with high activity and outstanding tolerability. Factors considered were drug transport through biologic membranes, the atomic and spatial structure of the molecule, and the electronic structure. Based on analysis of other nonsteroidal anti-inflammatory drugs, it was postulated that an effective antirheumatic agent should have the following characteristics: an acidity constant between 4 and 5, a partition coefficient of approximately 10, and two aromatic rings twisted in relation to each other. The result was diclofenac sodium, which has an acidity constant of 4.0 and a partition coefficient of 13.4. The structural elements include a phenylacetic acid group, a secondary amino group, and a phenyl ring containing chlorine atoms, which cause maximum twisting of the ring. Experimental and clinical findings obtained to date have indicated that diclofenac sodium was synthesized on well-founded principles.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D004008:Diclofenac / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen; D007192:Indenes; D007213:Indomethacin; D007660:Ketoprofen; D009288:Naproxen; D010653:Phenylbutazone; D010894:Piroxicam; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D013329:Structure-Activity Relationship; D013843:Thiazines
chemical_list: D007192:Indenes; D013843:Thiazines; D010894:Piroxicam; D004008:Diclofenac; D009288:Naproxen; D007660:Ketoprofen; D011451:Prostaglandin-Endoperoxide Synthases; D010653:Phenylbutazone; D007052:Ibuprofen; D007213:Indomethacin; C039724:oxindanac