[Functiono-morphologic substantiation of the diagnostic value of the atropine test in patients with duodenal ulcer].
The basal production of hydrochloric acid, pepsin, the level of immunoreactive gastrin-17 in the blood serum and gastric juice, endocrine G-, EcI- and Ec-cells of the gastric mucosa were studied in 42 patients with duodenal peptic ulcer. Patients with a negative atropine test were characterized by a high production of hydrochloric acid, hypergastrinemia, an elevated secretion of gastrin with gastric juice, hyperplasia of G- and EcI-cells. In a positive atropine test these indices were lower with the exception of a great amount of Ec-cells in the antral mucosa. Thus the atropine test reflected the functional-morphological arrangement of the secretory apparatus of the gastric mucosa and was of diagnostic value.
D000328:Adult; D001285:Atropine; D004381:Duodenal Ulcer / Q000473:pathology / Q000503:physiopathology*; D005744:Gastric Acid / Q000378:metabolism; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D006801:Humans; D010434:Pepsin A / Q000378:metabolism
D001285:Atropine; D010434:Pepsin A
Funktsional'no-morfologicheskoe obosnovanie diagnosticheskoĭ tsennosti atropinovogo testa u bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki.