title: The effect of chronic alcohol ingestion on the contractile proteins of the rat heart.
abstract: With increasing duration of alcohol consumption the amounts of total myofibrillar proteins in CFY rats decreased slightly, but significantly (from 63.3 +/- 5.7 mg X g wet muscle weight to 54.9 +/- 5.9 mg X g-1 after 12 weeks on alcohol). Similar slight changes could be observed in the case of sarcoplasmic proteins. No significant changes were observed in the composition of the myofibrillar proteins. The densitiometrically calculated percentage ratios of myosin/actin, myosin light chains (LC1/LC2) and troponin components remained the same in the alcoholic animals. The same distribution of native myosin isoenzymes was found in the ventricles of the alcoholic animals as in the controls. We found no electrophoretically detectable evidence that a change in the composition of the myofibrillar proteins is responsible for the decreased contractility of the rat heart following chronic alcohol ingestion.
mesh_terms: D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D002310:Cardiomyopathy, Alcoholic / Q000209:etiology; D003285:Contractile Proteins / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009210:Myofibrils / Q000378:metabolism; D009218:Myosins / Q000378:metabolism; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
chemical_list: D003285:Contractile Proteins; D009218:Myosins