Parasitological evaluation of curative and subcurative doses of 9-acridanone-hydrazone drugs against Schistosoma mansoni in baboons, and observations on changes in serum levels of anti-egg antibodies detected by ELISA.
Derivatives in the class of 9-acridanone-hydrazones were found to be highly active against Schistosoma mansoni in baboons. Single doses of 25 mg/kg were fully effective. Data are presented showing changes detected by ELISA in antibody levels against schistosome eggs which correlated positively with the effect of chemotherapy. This approach may help to evaluate the effects of treatment of human schistosomiasis where the detection of low egg counts is problematic.
D000166:Acridines / Q000008:administration & dosage* / Q000627:therapeutic use; D000818:Animals; D000906:Antibodies / Q000032:analysis*; D004353:Drug Evaluation, Preclinical; D004797:Enzyme-Linked Immunosorbent Assay; D006835:Hydrazones / Q000008:administration & dosage* / Q000627:therapeutic use; D010063:Ovum / Q000276:immunology; D010215:Papio; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000276:immunology; D012556:Schistosomicides / Q000008:administration & dosage* / Q000627:therapeutic use
D000166:Acridines; D000906:Antibodies; D006835:Hydrazones; D012556:Schistosomicides