Selective delivery of high levels of mitomycin C to peritoneal carcinomatosis using a new dosage form.
Selective delivery of a high level of Mitomycin C (MMC) in intraperitoneal disseminated lesions was studied using a new dosage form of MMC, called MMC-CH. Intracavitary MMC-CH delivered a much higher level of MMC selectively to intraperitoneal tissues, with a much lower level of MMC in the whole body, in comparison with MMC solution. The index [MMC level in the intraperitoneal organs]: [MMC level in blood] was much higher and increased with time in the MMC-CH group, but not in the MMC solution group.
D000818:Animals; D002277:Carcinoma / Q000188:drug therapy*; D007700:Kinetics; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage* / Q000627:therapeutic use; D009852:Omentum / Q000378:metabolism; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D011817:Rabbits; D014018:Tissue Distribution
D008937:Mitomycins; D016685:Mitomycin