An enhanced serum prolactin response to TRH in the presence of GABA transaminase inhibition.
Patients with epilepsy were found to have an increased 20 minute prolactin response to intravenous TRH stimulation when receiving the GABA-T inhibiting drug vigabatrin. Enhanced GABA activity may either reduce basal prolactin levels whilst allowing a normal pituitary response to TRH stimulation, or may overcome the inhibitory effects of dopamine on pituitary prolactin release.
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000293:Adolescent; D000328:Adult; D000614:Aminocaproates / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D011388:Prolactin / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D013997:Time Factors; D020888:Vigabatrin
D000614:Aminocaproates; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D013972:Thyrotropin; D000612:4-Aminobutyrate Transaminase; D020888:Vigabatrin