Turnover of central biogenic amines in two-kidney, one-clip renal hypertensive rats.
Turnover rates, as estimated from the accumulation of the intermediates dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) following decarboxylase inhibition, were used to investigate the relationship between central catecholaminergic and serotonergic neurons and the development of hypertension in 2-kidney, 1-clip renal hypertensive rats. Results indicated that at one week following clipping, DOPA accumulation was increased in the midbrain-pons. At 5 weeks no changes were observed. At 20 weeks a lower accumulation of both DOPA and 5-HTP was observed in the posterior hypothalamus while in the medulla oblongata DOPA accumulation was lower and in the midbrain-pons 5-HTP accumulation was reduced.
D006916:5-Hydroxytryptophan / Q000032:analysis; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001794:Blood Pressure; D001921:Brain / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004295:Dihydroxyphenylalanine / Q000032:analysis; D004195:Disease Models, Animal; D006977:Hypertension, Renal / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012078:Renal Artery Obstruction
D001679:Biogenic Amines; D004295:Dihydroxyphenylalanine; D006916:5-Hydroxytryptophan