title: Dietary fatty acids and platelet thromboxane production in puerperal women and their offspring.
abstract: The effects of the ratio of polyunsaturated to saturated fatty acids in the diet of puerperal women on maternal and neonatal fatty acids and thromboxane A2 synthesis were studied in 91 mother-infant pairs on the fourth to fifth day after delivery. The mothers received a diet with either a low (0.1) or a high (1.5) polyunsaturated to saturated fatty acid ratio for 4 to 5 days. The fatty acid composition in maternal and neonatal serum and in breast milk was determined in 34 mother-infant pairs from both dietary groups. The capacity of the platelets to produce thromboxane B2, a stable metabolite of thromboxane A2, was determined in another 57 mother-infant pairs. The percentage of linoleic acid was increased in maternal and neonatal sera as well as in the breast milk in the group with a high dietary polyunsaturated to saturated fatty acid ratio, whereas the content of arachidonic acid was increased only in maternal serum. This was accompanied by increased platelet thromboxane B2 production in the mothers, and maternal and neonatal thromboxane B2 synthesis correlated significantly with each other (r = 0.43, p less than 0.05). This finding may provide therapeutic possibilities in the future.
mesh_terms: D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000032:analysis / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D004032:Diet; D005227:Fatty Acids / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000032:analysis / Q000097:blood; D008895:Milk, Human / Q000032:analysis; D049590:Postpartum Period; D011247:Pregnancy; D013931:Thromboxanes / Q000096:biosynthesis*
chemical_list: D001095:Arachidonic Acids; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D013931:Thromboxanes; D016718:Arachidonic Acid; D019787:Linoleic Acid