Results of in vivo and in vitro studies for assessing prenatal toxicity.
Examples of a combined approach using in vivo as well as in vitro methods for the assessment of prenatal toxicity are presented. The topics discussed include the analysis of the possible embryotoxic potential of valproic acid (VPA), female sex hormones, bis(tri-n-butyltin) oxide (TBTO), and acyclovir and the problem of supplementing in vitro systems with drug-metabolizing activity.
D000014:Abnormalities, Drug-Induced / Q000473:pathology*; D000212:Acyclovir / Q000633:toxicity*; D000818:Animals; D004202:Disinfectants / Q000633:toxicity; D004622:Embryo, Mammalian / Q000187:drug effects*; D004967:Estrogens / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D009924:Organ Culture Techniques / Q000379:methods; D011374:Progesterone / Q000633:toxicity*; D051381:Rats; D013723:Teratogens; D014220:Trialkyltin Compounds / Q000633:toxicity*; D014635:Valproic Acid / Q000633:toxicity*
D004202:Disinfectants; D004967:Estrogens; D013723:Teratogens; D014220:Trialkyltin Compounds; C005961:bis(tri-n-butyltin)oxide; D011374:Progesterone; D014635:Valproic Acid; D000212:Acyclovir