Effect of arachidonic acid on anthralin inflammation.
1 The effect of topical arachidonic acid on anthralin inflammation was studied using sequential measurements of erythema (reflectance photometry) and oedema (calipers). 2 Topical arachidonic acid in concentrations which produced a small short-lived inflammatory response greatly augmented the initial phase and depressed the later phase of the inflammatory response to anthralin. 3 The initial augmentation was inhibited by concomitant administration of alpha-tocopherol. 4 It is suggested that free radical formation by anthralin has a direct action on membrane substrates such as arachidonic acid forming inflammatory products by a non-enzymic process.
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000875:Anthralin / Q000633:toxicity; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D004224:Diterpenes; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004890:Erythema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D005609:Free Radicals; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D000084562:Retinyl Esters; D013997:Time Factors; D014801:Vitamin A / Q000031:analogs & derivatives / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
D001095:Arachidonic Acids; D004224:Diterpenes; D005609:Free Radicals; D000084562:Retinyl Esters; D014801:Vitamin A; D014810:Vitamin E; C014794:retinol palmitate; D016718:Arachidonic Acid; D000875:Anthralin