[A new test for evaluating the von Willebrand factor: collagen-induced agglutination of fixed thrombocytes].
In primary hemostasis von Willebrand factor (vWf) promotes the adhesion of platelets to subendothelial structures of the damaged blood vessel. A new test is described which measures the collagen binding affinity of vWf. Activities of vWf in plasmas of 51 patients were measured with either collagen (ColCof) or ristocetin (RCof). Regression-analysis showed a good correlation of both activities (r = 0.924). In a second group of 21 patients with a variant of von Willebrand's disease, ColCof activity was generally higher than RCof activity.
D003094:Collagen / Q000378:metabolism; D005169:Factor VIII / Q000378:metabolism / Q000592:standards*; D006801:Humans; D010973:Platelet Adhesiveness / Q000187:drug effects; D012310:Ristocetin / Q000494:pharmacology
D012310:Ristocetin; D005169:Factor VIII; D003094:Collagen
Ein neuer Test für die Beurteilung des von Willebrand-Faktors: kollagen-induzierte Agglutination fixierter Thrombozyten.