Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease.
Microtubule associated protein tau factor self-assembles into filamentous structures resembling the paired helical filaments found in Alzheimer disease. Tau polymerization requires of a previous modification; conversion of glutamine into glutamic acid by deamination.
D000544:Alzheimer Disease / Q000473:pathology*; D000818:Animals; D005971:Glutamates / Q000378:metabolism; D005972:Glutaminase / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D046911:Macromolecular Substances; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D009454:Neurofibrils / Q000648:ultrastructure*; D010446:Peptide Fragments / Q000032:analysis; D011108:Polymers; D011485:Protein Binding; D013552:Swine; D016875:tau Proteins
D005971:Glutamates; D046911:Macromolecular Substances; D008869:Microtubule-Associated Proteins; D010446:Peptide Fragments; D011108:Polymers; D016875:tau Proteins; D005973:Glutamine; D005972:Glutaminase