Laminar air flow isolation and decontamination: a prospective randomized study of the effects of prophylactic systemic antibiotics in bone marrow transplant patients.
122 patients with hematologic malignancies underwent allogeneic marrow transplantation from HLA-matched sibling donors and received one of two forms of infection prophylaxis while granulocytopenic: 1) decontamination and laminar air flow isolation (LAF, 68 patients), and 2) LAF plus prophylactic systemic antibiotics (LAF + PSA, 54 patients). Patients were evaluated for infection acquisition while in isolation. Septicemia occurred in 11 (16%) of the patients in the LAF group and in three (6%) patients in the LAF + PSA group. Fourteen (21%) of the patients in the LAF group and four (7%) patients in the LAF + PSA group had a major local infection. There was no difference in the incidence and severity of graft-versus-host disease or incidence and duration of fever. The addition of prophylactic intravenous broad-spectrum antibiotics for patients isolated in LAF rooms significantly decreased infection acquisition.
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D004780:Environment, Controlled; D006086:Graft vs Host Disease / Q000453:epidemiology; D006098:Granulocytes; D006801:Humans; D017053:Infection Control; D007239:Infections / Q000453:epidemiology; D007958:Leukocyte Count; D008875:Middle Aged; D010356:Patient Isolation; D011292:Premedication; D011446:Prospective Studies; D011658:Pulmonary Fibrosis / Q000453:epidemiology; D011897:Random Allocation; D018805:Sepsis / Q000453:epidemiology / Q000517:prevention & control; D013242:Sterilization
D000900:Anti-Bacterial Agents