Perturbed hemopoiesis and the generation of multipotential stem cell clones in src-infected bone marrow cultures is an indirect or transient effect of the oncogene.
Multipotential stem cell lines, derived specifically from long-term bone marrow cultures infected with a recombinant retrovirus carrying v-src, lack v-src. Stable consequences thus result from transient actions or indirect effects of v-src on other cells, with the latter possibility being favored by its mosaic expression in marrow cultures.
D000818:Animals; D001854:Bone Marrow Cells; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D005796:Genes; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D051379:Mice; D008979:Moloney murine leukemia virus / Q000235:genetics*; D015688:Oncogene Protein pp60(v-src); D009857:Oncogenes; D012191:Retroviridae Proteins / Q000032:analysis / Q000235:genetics*
D012191:Retroviridae Proteins; D015688:Oncogene Protein pp60(v-src)