Disposition of chloramphenicol in young rhesus monkeys with protein-energy malnutrition.
The disposition of chloramphenicol was studied in young rhesus monkeys at three levels of nutrition: control, protein-energy deficiency, and following nutritional rehabilitation. During the malnutrition phase, the plasma elimination half-life was prolonged and the plasma clearance was reduced. Simultaneously there was a decrease in the activity of chloramphenicol-specific UDP-glucuronyl transferase. These changes were reversible following nutritional rehabilitation.
D000818:Animals; D001711:Biotransformation; D002701:Chloramphenicol / Q000378:metabolism*; D014453:Glucuronosyltransferase / Q000378:metabolism; D007408:Intestinal Absorption; D007700:Kinetics; D008253:Macaca mulatta; D008297:Male; D011502:Protein-Energy Malnutrition / Q000378:metabolism*
D002701:Chloramphenicol; D014453:Glucuronosyltransferase