Fluoxetine suppresses palatability-induced ingestion.
Non-deprived rats were allowed 1-h access to a range of saccharin solutions from 0.001 to 0.1 M Na saccharin. Compared to a group of rats drinking tap water, the rats drinking the saccharin solutions ingested a great deal more fluid, with as much as 24-30 ml consumed of the 0.01 M concentration, compared to 3-5 ml in controls. Fluoxetine (IP) decreased this palatability-induced excessive consumption in a dose-related manner. Effects of 10 mg/kg fluoxetine were apparent for 48 h after injection. This effect on palatability-induced ingestion may relate to previously reported effects of fluoxetine on food consumption.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D005473:Fluoxetine / Q000494:pharmacology*; D008297:Male; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D012439:Saccharin / Q000494:pharmacology; D013649:Taste / Q000187:drug effects*
D011437:Propylamines; D005473:Fluoxetine; D012439:Saccharin