title: Effect of ebony and yellow mutants of Drosophila melanogaster on adult survival and alcohol dehydrogenase activity.
abstract: The survival of ebony, yellow, ebony-yellow double mutant and their wild type was studied on two types of media. All genotypes showed greater survival in the presence of 10% ethanol (E) than on the control agar medium (C), with wild type showing greatest and the double mutant ebony-yellow least response. This increase in survival on E was negatively dependent on that on C. The relationship between alcohol dehydrogenase (ADH) activity and survival appeared to be negative on E. On C it was either slightly positive for males or constant for females. The degree of survival increase standardized in relation to survival on C [(E-C)/C] was more dependent on the level of ADH activity for the males (r = -0.98; p greater than 0.05) than for the females (r = -0.38; NS). In the complex interaction between morphogenes, ADH activity and survival, morphogenes increased the ADH activity and decreased survival on E.
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000818:Animals; D003470:Culture Media; D004331:Drosophila melanogaster; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D005838:Genotype; D008136:Longevity / Q000187:drug effects; D008297:Male; D009154:Mutation
chemical_list: D003470:Culture Media; D000431:Ethanol; D000426:Alcohol Dehydrogenase