Inhibition of fibrosis in TSK mice by blocking mast cell degranulation.
The Tsk mouse has a genetically transmitted connective tissue disease whose skin lesions resemble those of scleroderma. After treatment with disodium cromoglycate, a marked decrease in skin fibrosis was observed, raising the possibility that disodium cromoglycate may be a potential treatment for human scleroderma.
D000818:Animals; D002452:Cell Count; D004205:Cromolyn Sodium / Q000494:pharmacology*; D003594:Cytoplasmic Granules / Q000187:drug effects*; D005355:Fibrosis; D008407:Mast Cells / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D012867:Skin / Q000473:pathology; D012868:Skin Abnormalities
D004205:Cromolyn Sodium