Prediction of therapeutic lithium dose: comparison and improvement of current methods.
The predictive value of two methods of predicting therapeutic lithium dose was evaluated in 19 patients. A single time point lithium level determination method, modified by the use of a 900-mg instead of a 600-mg test dose, was found to be a reliable and safe predictor. A mathematical model used for predictions was found to be moderately accurate but to generally predict a lower dose than was actually required.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001702:Biopharmaceutics; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008094:Lithium / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism; D016651:Lithium Carbonate; D008297:Male; D001523:Mental Disorders / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D008875:Middle Aged; D011336:Probability
D016651:Lithium Carbonate; D008094:Lithium