Gm allotyping to determine the origin of the anti-D causing hemolytic anemia in a kidney transplant recipient.
Anti-D causing mild hemolytic anemia was found in the serum and on the red cells of a D-positive patient who had received a kidney transplant from his D-negative mother. Anti-D had been detected in the donor's serum before transplantation. Gm allotyping of the patient's serum, donor's serum, donor's anti-D, and the unexpected anti-D in the posttransplantation serum showed the antibody to be of maternal origin. The patient was Gm(fb), the donor Gm(agfb), the maternal anti-D Gm (afb), and the anti-D in the posttransplantation serum was Gm(a).
D000328:Adult; D000743:Anemia, Hemolytic / Q000276:immunology*; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000032:analysis*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D014019:Tissue Donors
D007129:Immunoglobulin Gm Allotypes; D012204:Rh-Hr Blood-Group System