[Anti-Coxsackie antibodies and congestive cardiomyopathies].
During a 4-years period 122 patients admitted to the cardiologic hospital in Lille presented a significative positivity of serological reaction against Coxsackievirus B. Among these patients 19 suffered from acute pericarditis, 4 from cardiac arrhythmias, 3 from Bornholm syndrome and 14 from apparently primary congestive cardiomyopathy. In most of these 14 patients representing 18.4% of congestive cardiomyopathies investigated at the same time, hemodynamic studies and heart scanning with radioactive gallium were performed. 7 of these patients had a chronic (group A) and 7 an acute evolution (group B). In group A the scans were negative 4 times out of 5, whereas in group B they were positive in 5 out of 5 examinations. The control group including 3247 patients coming from the Institut Pasteur exhibited serological positivity in 4.6% of cases. Comparison of this group with that of cardiomyopathies shows a significant difference (p less than 0.001). The authors draw the attention to the frequency of positive serodiagnosis in congestive cardiomyopathy and stress the importance of gallium scintiscanning.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D001379:Azathioprine / Q000627:therapeutic use; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D003384:Coxsackievirus Infections / Q000150:complications*; D004770:Enterovirus / Q000276:immunology*; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000209:etiology; D011241:Prednisone / Q000627:therapeutic use; D011877:Radionuclide Imaging
D000914:Antibodies, Viral; D001379:Azathioprine; D011241:Prednisone
Anticorps anti-Coxsackies et cardiomyopathies congestives.