T-cell subsets in the murine thymus during chemically induced leukemogenesis.
T cell leukemias were induced in BDF 1 mice by methylnitrosourea (MNU). The phenotype of the leukemic cells is Thy1.2 +, PNA-, TdT+, TL+ and heterogeneous with respect to Lyt-1 and Lyt-2. About 70% of the leukemias have elevated amounts of gp70. During latency period of at least 9 + 12 weeks an early reduction in the various thymic cells and the CFU-S is observed, with almost complete recovery. Later PNA+ cells are reduced. Hydrocortisone treatment delays or enhances leukemogenesis, dependent on the time interval between hydrocortisone and MNU. Some mice show elevated amounts of gp70 in their bone marrow 2--3 weeks after MNU. The problem of target cells in the bone marrow and the thymus is discussed.
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000032:analysis; D002454:Cell Differentiation; D004347:Drug Interactions; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006854:Hydrocortisone / Q000494:pharmacology; D007942:Leukemia, Experimental / Q000139:chemically induced* / Q000276:immunology / Q000517:prevention & control; D008770:Methylnitrosourea / Q000633:toxicity; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D013997:Time Factors; D014410:Tumor Stem Cell Assay
D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D006023:Glycoproteins; C033589:glycoprotein gp70, murine serum; D008770:Methylnitrosourea; D006854:Hydrocortisone