The actions of interferon and antiinflammatory agents of induction of indoleamine 2,3-dioxygenase in human peripheral blood monocytes.
Interferon substantially induced indoleamine 2,3-dioxygenase and increased L-tryptophan metabolism in human peripheral blood monocytes. The induction of dioxygenase by gamma-interferon was significantly higher than that observed with alpha-interferon. This cytokine-dependent induction of the enzyme was markedly and differentially altered by antiinflammatory drugs (i.e., acetaminophen, 3-deazaadenosine, indomethacin and dexamethasone). Dexamethasone potentiated the effect of gamma-interferon and resulted in "super-induction" of the enzyme. This is the first demonstration of the interferon-elicited induction of the dioxygenase in the cells of the immune system and of a novel mechanism for regulating tryptophan metabolism in the cells.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004790:Enzyme Induction; D006801:Humans; D007370:Interferon Type I / Q000502:physiology*; D007371:Interferon-gamma / Q000502:physiology*; D007700:Kinetics; D007737:Kynurenine / Q000097:blood; D009000:Monocytes / Q000187:drug effects / Q000201:enzymology* / Q000276:immunology; D010105:Oxygenases / Q000096:biosynthesis*; D014364:Tryptophan / Q000097:blood; D014366:Tryptophan Oxygenase
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007370:Interferon Type I; D007737:Kynurenine; D007371:Interferon-gamma; D014364:Tryptophan; D010105:Oxygenases; D014366:Tryptophan Oxygenase