title: Effects of serum carrier proteins on the growth of pathogenic neisseriae with heme-bound iron.
abstract: The pathogenic neisseriae can use free heme and hemoglobin as an essential source of iron (Fe) for growth in vitro, but it is unknown whether they can utilize heme bound to human hemopexin or to human serum albumin, or hemoglobin bound to haptoglobin. We found that neither Neisseria meningitidis nor Neisseria gonorrhoeae used bound heme, but bound hemoglobin was used as an Fe source by two meningococcal strains and one gonococcal strain. A second gonococcal strain, previously shown to use free hemoglobin poorly or not at all, also did not grow with hemoglobin-haptoglobin complex as an Fe source. These observations suggest that hemoglobin might act as an Fe source in vivo for many pathogenic neisseriae even when in complexed (bound) form, but heme probably would not support growth in vivo if bound to serum carrier proteins.
mesh_terms: D001798:Blood Proteins / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D006242:Haptoglobins / Q000378:metabolism; D006418:Heme / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D006466:Hemopexin / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D009344:Neisseria gonorrhoeae / Q000254:growth & development*; D009345:Neisseria meningitidis / Q000254:growth & development*; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D001798:Blood Proteins; D002352:Carrier Proteins; D006242:Haptoglobins; D006454:Hemoglobins; D012709:Serum Albumin; D006418:Heme; D006466:Hemopexin; D007501:Iron