title: Intravenous feeding with medium chain triglycerides. Effect on blood gases and the complement system in critically ill patients.
abstract: Critically ill patients are usually in a catabolic state and may require total parenteral nutrition; this often includes lipid emulsions. Any adverse effects of constituents on pulmonary function, white cell function or the haemocoagulation system could have disastrous consequences in such patients. We have investigated the effects of a new intravenous lipid preparation containing medium chain triglycerides, which, in severely ill malnourished patients are theoretically a preferable energy source to conventional drug chain triglycerides. In a pilot study 17 critically ill patients whose lungs were artificially ventilated were given this lipid emulsion; no adverse effects were observed. Arterial oxygen and carbon dioxide tensions, ratio of inspired oxygen fractional concentration to arterial oxygen tension, platelet and white cell counts all remained constant and the complement system was not activated.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D002245:Carbon Dioxide / Q000097:blood; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003422:Critical Care; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010289:Parenteral Nutrition, Total; D010743:Phospholipids / Q000627:therapeutic use*; D010865:Pilot Projects; D013012:Sorbitol / Q000627:therapeutic use*; D014280:Triglycerides / Q000627:therapeutic use*
chemical_list: D003176:Complement C3; D003181:Complement C4; D004338:Drug Combinations; D010743:Phospholipids; D014280:Triglycerides; C008288:Lipofundin; D002245:Carbon Dioxide; D013012:Sorbitol; D010100:Oxygen