title: Immunologic disorders: the regulation of humoral immunity.
abstract: The modulation of humoral immunity by complement and complement receptors is presented, as well as the importance of the X chromosome in immune response. Gene rearrangement and ontogeny of the immunoglobulin isotypes are discussed with regard to humoral immunodeficiency diseases.
mesh_terms: D000361:Agammaglobulinemia / Q000235:genetics; D000917:Antibody Formation / Q000187:drug effects; D002874:Chromosome Mapping; D003165:Complement System Proteins / Q000502:physiology; D005260:Female; D005796:Genes; D006801:Humans; D007154:Immune System Diseases / Q000276:immunology*; D007127:Immunoglobulin Constant Regions / Q000235:genetics; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007132:Immunoglobulin Isotypes / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D008297:Male; D011951:Receptors, Complement / Q000502:physiology; D014960:X Chromosome
chemical_list: D007127:Immunoglobulin Constant Regions; D007143:Immunoglobulin Heavy Chains; D007132:Immunoglobulin Isotypes; D007135:Immunoglobulin Variable Region; D011951:Receptors, Complement; D003165:Complement System Proteins