Regulation of muscle fructose 2, 6-bisphosphate levels by sulfonylureas.
We examined the effect of sulfonylureas on the level of fructose 2, 6-bisphosphate (F-2, 6-P2) in muscle using a mouse hindlimb flow-through perfusion system. The F-2, 6-P2 level in muscle was increased by adding glibenclamide or tolbutamide in a dose-dependent manner. The stimulatory potency of each drug on F-2, 6-P2 formation was parallel to its hypoglycemic potency. Sulfonylurea stimulation of muscle F-2, 6-P2 formation is thought to be an important extrapancreatic action improving the deranged carbohydrate metabolism in diabetics.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005635:Fructosediphosphates / Q000378:metabolism*; D005905:Glyburide / Q000494:pharmacology; D006598:Hexosediphosphates / Q000378:metabolism*; D051379:Mice; D009132:Muscles / Q000378:metabolism*; D010477:Perfusion; D013453:Sulfonylurea Compounds / Q000494:pharmacology*; D014044:Tolbutamide / Q000494:pharmacology
D005635:Fructosediphosphates; D006598:Hexosediphosphates; D013453:Sulfonylurea Compounds; D014044:Tolbutamide; D005905:Glyburide