Influence of monoclonal antibodies against HLA class I and class II antigen on interferon-gamma and -alpha induction.
The effects of several monoclonal antibodies (MAbs) directed against different epitopes of HLA class I and class II antigens on interferon (IFN)-gamma and IFN-alpha production were studied. The results indicate that: these MAbs have a marked inhibitory effect on the production of IFN-gamma induced by alloantigens and microbial antigens; they influence only to a lesser extent staphylococcal enterotoxin B (SEB)- and phytohemagglutinin (PHA)-induced IFN-gamma production; such effects parallel inhibition of lymphoproliferation except for PHA-induced blastogenesis, which is not affected; on the other hand, these MAbs have no effect on the production of IFN-alpha induced by lipopolysaccharide (LPS) or viruses.
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000936:Antigen-Antibody Complex; D002478:Cells, Cultured; D006680:HLA Antigens / Q000276:immunology*; D006681:HLA-D Antigens / Q000276:immunology*; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis* / Q000276:immunology; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000276:immunology; D007700:Kinetics; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D006680:HLA Antigens; D006681:HLA-D Antigens; D007370:Interferon Type I; D007371:Interferon-gamma