title: Haemostatic abnormalities in canine Cushing's syndrome.
abstract: Selected parameters of the haemostatic system were evaluated in 12 consecutive cases of canine Cushing's syndrome. The dogs did not exhibit evidence of thromboembolic complications. Levels of factors V and X were increased significantly (P less than 0.01) and fibrinogen concentration was increased modestly (P less than 0.05) in these dogs. Levels of factors IX and VIII:C remained in the reference range. Antithrombin III (ATIII) and plasminogen concentrations were markedly elevated (P less than 0.001). The low factor VIII:C and elevated ATIII levels in the plasma were not consistent with characteristics of a hypercoagulable state. These results demonstrated that haemostatic abnormalities which occur in canine Cushing's syndrome do not necessarily represent a state predisposed to thrombosis.
mesh_terms: D000818:Animals; D000990:Antithrombin III / Q000032:analysis; D003480:Cushing Syndrome / Q000097:blood / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005164:Factor IX / Q000032:analysis; D005165:Factor V / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005170:Factor X / Q000032:analysis; D005260:Female; D006487:Hemostasis; D008297:Male; D010958:Plasminogen / Q000032:analysis
chemical_list: D000990:Antithrombin III; D005165:Factor V; D005169:Factor VIII; D005164:Factor IX; D005170:Factor X; D010958:Plasminogen