Stimulation of cyclooxygenase by activated human neutrophils is enhanced by uric acid.
Activated human neutrophils supernatant enhances prostanoids production by bull seminal cyclooxygenase (455% of control). Superoxide anion and hydrogen peroxide are not involved in this stimulation, in these experimental conditions. Myeloperoxidase (by its hemic nature) and HPETEs (by their -OOH function) could trigger cyclooxygenase. In the presence of uric acid (10(-3) M), a potent hydroxyl radical scavenger, the cyclooxygenase stimulation by supernatant is increased until 709% of the control.
D000818:Animals; D002417:Cattle; D004357:Drug Synergism; D004789:Enzyme Activation; D006801:Humans; D007700:Kinetics; D008297:Male; D008861:Microsomes / Q000201:enzymology; D009504:Neutrophils / Q000502:physiology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D012669:Seminal Vesicles / Q000201:enzymology; D014020:Tissue Extracts / Q000494:pharmacology*; D014527:Uric Acid / Q000494:pharmacology*
D014020:Tissue Extracts; D014527:Uric Acid; D011451:Prostaglandin-Endoperoxide Synthases