Bile pigments inhibit microsomal lipid peroxidation.
Bile pigments (bilirubin and biliverdin) inhibit lipid peroxidation in rat liver microsomes at physiological concentrations. Since an alternative course for bilirubin degradation involving superoxide radical has been described, a possible explanation of the decrease of the initial rate of lipid peroxidation could be the scavenging of .O2-.
D000818:Animals; D001663:Bilirubin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D001664:Biliverdine / Q000494:pharmacology*; D007700:Kinetics; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D051381:Rats
D008054:Lipid Peroxides; D009249:NADP; D001664:Biliverdine; D001663:Bilirubin