Anti-inflammatory activity of IFN-beta in carrageenan-induced pleurisy in the mouse.
The effect of IFN-beta on the development of the inflammatory reaction was studied in an experimental animal model, carrageenan-induced pleurisy in the mouse. Intrapleural inoculation of IFN-beta at the same time as carrageenan administration inhibited both migration of inflammatory cells and exudate formation in the pleural cavity in a dose-dependent fashion. Similarly, IFN-beta decreased the presence of the arachidonate metabolites PGI2, TXA2 and PGE2 (highly active molecules involved in the regulation of the inflammatory reaction) in inflammatory exudates. A marked inhibition of the inflammatory response to carrageenan was also evident when IFN-beta was administered several hours after the inflammatory challenge. In contrast, administration of IFN-gamma did not modify significantly any of the inflammatory parameters considered.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D007370:Interferon Type I / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D010998:Pleurisy / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*
D001095:Arachidonic Acids; D007370:Interferon Type I; D007371:Interferon-gamma; D002351:Carrageenan