Inhibition of the shake response in rats by adenosine and 2-chloroadenosine.
Shaking movements, similar to those made by a dog when wet, were elicited in rats by immersion in ice-water, injections of icilin, a chemical that produces sensations of cold, and naloxone-precipitated morphine withdrawal. Adenosine and 2-chloroadenosine produced dose-dependent inhibition of shaking to ice-water and icilin. The 2-chloroadenosine effect was mediated centrally because the ICV dose required to produce inhibition was not effective when given IP. Caffeine antagonized the inhibitory effects of adenosine and 2-chloroadenosine. 2-Chloroadenosine suppressed morphine-abstinence shaking as well as the body weight loss that normally accompanies withdrawal.
D015762:2-Chloroadenosine; D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003080:Cold Temperature; D004305:Dose-Response Relationship, Drug; D008297:Male; D009020:Morphine / Q000009:adverse effects; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D051381:Rats; D012768:Shivering / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy
D009125:Muscle Relaxants, Central; D015762:2-Chloroadenosine; D009020:Morphine; D000241:Adenosine