title: Tissue plasminogen activator: from molecular biology to myocardial infarction.
abstract: The recent development of recombinant tissue plasminogen activator as a therapeutic agent during acute myocardial infarction is one of the most lucid examples of the potential impact of recombinant DNA technology in clinical medicine. This remarkable achievement would not have been possible without several key discoveries in molecular biology and clinical cardiology and exemplifies the synergistic relationship between basic and clinical research. This article chronicles this journey from molecular biology to myocardial infarction.
mesh_terms: D005342:Fibrinolysis; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006023:Glycoproteins / Q000502:physiology; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D015849:Plasminogen Inactivators; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000627:therapeutic use; D010959:Tissue Plasminogen Activator / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D006023:Glycoproteins; D015849:Plasminogen Inactivators; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator