Clomiphene citrate response is predictable in corpus luteum insufficiency.
In order to predict the correct dose of clomiphene citrate in corpus luteum insufficiency, the results of the treatment of 117 patients were evaluated. Serum progesterone and prolactin concentrations were determined by RIA. A 3-fold increase in serum progesterone concentration was found following the 100 mg per day clomiphene citrate treatment, independently of the pretreatment progesterone or prolactin values. This means that in a well-selected, hormonally homogeneous group of patients, contrary to earlier observations, the clomiphene citrate sensitivity of the patients is predictable.
D002996:Clomiphene / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D003338:Corpus Luteum / Q000187:drug effects*; D005260:Female; D006801:Humans; D010049:Ovarian Diseases / Q000097:blood / Q000188:drug therapy*; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood
D002996:Clomiphene; D011374:Progesterone; D011388:Prolactin