[Effect of a hypertonic mannitol solution on the peri-infarct area of an isolated frog heart].
The influence of the hypertonic (3%) solution of mannitol on the process of the excitability recovery (in the near necrotic zone) appeared as a result of the necroses tissue effect on the ventricle has been investigated in the experiments on the isolated frog's heart. The analogous perfusion was conducted by Ringer solution in the control experiments. The process of isopotential phase S-T recovery was practically the same at heart perfusion with Ringer solution or with mannitol. Simultaneous registration of ventricular mechanogram showed the pronounced negative inotropic effect of mannitol. It is suggested that the positive effect of mannitol which has been noted under clinic conditions during the treatment of ischemic disease, doesn't connect with the effect of hypertonic solution on the cells excitability of periinfarcted (near necrotic) zone.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003864:Depression, Chemical; D004353:Drug Evaluation, Preclinical; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D006982:Hypertonic Solutions; D066298:In Vitro Techniques; D007552:Isotonic Solutions; D008353:Mannitol / Q000627:therapeutic use*; D008564:Membrane Potentials / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D011896:Rana temporaria; D000077331:Ringer's Solution
D006982:Hypertonic Solutions; D007552:Isotonic Solutions; D008353:Mannitol; D000077331:Ringer's Solution
Vliianie gipertonicheskogo rastvora mannitola na periinfarktnuiu zonu izolirovannogo serdtsa liagushki.