[Antisoporific and cardiotropic properties of new amino acid derivatives of nicotinic acid].
On the models of urethane, nembutal and ethyl alcohol sleep it was shown that nicotinoylcapronate, nicotinoylserine and nicotinoylvaline possess antihypnotic properties being superior to those of cordiamine and on some models phenamine. Nicotinoylvaline and nicotinoylalanine normalized the myocardial contraction in animals with experimental ischemia.
D000409:Alanine / Q000494:pharmacology / Q000633:toxicity; D000596:Amino Acids / Q000494:pharmacology* / Q000633:toxicity; D000661:Amphetamine / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D002208:Caproates / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000494:pharmacology*; D002415:Cats; D003327:Coronary Disease / Q000503:physiopathology; D006993:Hypnotics and Sedatives / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D051379:Mice; D009200:Myocardial Contraction / Q000187:drug effects; D009539:Nicotinic Acids / Q000494:pharmacology* / Q000633:toxicity; D009552:Nikethamide / Q000494:pharmacology; D011898:Ranidae; D012694:Serine / Q000494:pharmacology / Q000633:toxicity; D012890:Sleep / Q000187:drug effects; D014633:Valine / Q000494:pharmacology / Q000633:toxicity; D014700:Verapamil / Q000494:pharmacology
D000596:Amino Acids; D002208:Caproates; D002317:Cardiovascular Agents; D006993:Hypnotics and Sedatives; D009539:Nicotinic Acids; D009552:Nikethamide; D012694:Serine; D014700:Verapamil; D000661:Amphetamine; D014633:Valine; D000409:Alanine
Antisnotvornye o kardiotropnye svoĭstva nekotorykh novykh aminokislotnykh proizvodnykh nikotinovoĭ kisloty.