Ornithine decarboxylase inhibition and the uterotrophic response to oestrogen in rats.
Pretreatment of mature ovariectomized rats with DL-5 alpha-difluoromethylornithine (DFMO) inhibits the 6-h uterine blood flow response to oestradiol and also depresses the stimulatory effect of oestradiol on wet and dry uterine weight. Results from this study indicate that polyamine synthesis is implicated in the uterine response to oestrogen.
D000818:Animals; D001834:Body Water / Q000187:drug effects; D003283:Contraceptives, Postcoital, Synthetic / Q000494:pharmacology; D000518:Eflornithine; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D009929:Organ Size / Q000187:drug effects; D009952:Ornithine / Q000031:analogs & derivatives* / Q000494:pharmacology; D065108:Ornithine Decarboxylase Inhibitors; D010052:Ovariectomy; D011073:Polyamines / Q000378:metabolism; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D014599:Uterus / Q000033:anatomy & histology / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism
D003283:Contraceptives, Postcoital, Synthetic; D065108:Ornithine Decarboxylase Inhibitors; D011073:Polyamines; D004958:Estradiol; D009952:Ornithine; D000518:Eflornithine