Suppression by neurotropin of production of human immuno-deficiency virus by the virus-producing MOLT-4 cell line.
The effect of neurotropin on human immuno-deficiency virus (HIV) production in a virus-producing MOLT-4 (MOLT-4/HTLV-III) cell line was studied. Culture of the cells for 4 days in the presence of 100 micrograms/ml of neurotropin resulted in a 72% decrease in the number of infectious virus particles released into the culture fluid. A pulse-labeling experiment to analyze the synthesis of HIV proteins suggested that neurotropin may affect the budding process of the virus.
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000954:Antigens, Surface / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D006678:HIV / Q000502:physiology*; D006801:Humans; D011134:Polysaccharides / Q000494:pharmacology* / Q000627:therapeutic use; D013936:Thymidine / Q000031:analogs & derivatives / Q000494:pharmacology; D014771:Virion / Q000032:analysis; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine
D000954:Antigens, Surface; D000956:Antigens, Viral; D011134:Polysaccharides; D015215:Zidovudine; C010491:neurotropin; D013936:Thymidine