Effects of benzamide pretreatment on clastogenic adaptation of Vicia faba root-tip meristem cells to triethylenemelamine (TEM) and maleic hydrazide (MH).
Clastogenic adaptation to TEM or MH no longer occurred when benzamide, an inhibitor of nuclear ADP-ribosyltransferase (ADPRT), was applied prior to the low dose (conditioning) treatment which triggers this phenomenon. This may be indicative that inducible processes connected with ribosylation reactions are involved in the protective effects exerted by clastogenic adaptation. No increase by benzamide pretreatment was observed in the yield of metaphases with TEM- or MH-induced chromatid aberrations after conditioning and challenge treatment, respectively. High benzamide concentrations (1 h, 5 X 10(-3) M) exerted protective effects against TEM challenging but not against MH.
D001549:Benzamides / Q000494:pharmacology*; D002842:Chromatids / Q000187:drug effects*; D007887:Fabaceae / Q000187:drug effects*; D008300:Maleic Hydrazide / Q000494:pharmacology*; D009152:Mutagenicity Tests; D010946:Plants, Medicinal; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011724:Pyridazines / Q000494:pharmacology*; D014265:Triethylenemelamine / Q000494:pharmacology*
D001549:Benzamides; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011724:Pyridazines; C037689:benzamide; D014265:Triethylenemelamine; D008300:Maleic Hydrazide