Hypoxanthine and xanthine in stored SAGM-blood.
The concentration of xanthine and hypoxanthine was measured in 8 portions of SAGM red cell concentrates during 4 wk storage. The concentration of xanthine increased from 4.2 to 35.1 mumol/l and the concentration of hypoxanthine increased from 16.8 to 165.2 mumol/l (mean values). Previous studies have demonstrated several important effects of purine bases--among these a reduced cytotoxicity of purine antimetabolites. It is concluded that further studies are necessary to investigate the clinical role of purines in stored blood products.
D000225:Adenine; D001793:Blood Preservation; D005947:Glucose; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000097:blood*; D008353:Mannitol; D012965:Sodium Chloride; D013997:Time Factors; D019820:Xanthine; D014970:Xanthines / Q000097:blood*
C037839:ADSOL; D007042:Hypoxanthines; D014970:Xanthines; D019820:Xanthine; D019271:Hypoxanthine; D008353:Mannitol; D012965:Sodium Chloride; D005947:Glucose; D000225:Adenine