title: RO 15-1788 decreases hypnotic effects of sleep deprivation.
abstract: The present study investigated the effects of 5 mg, 60 mg and 120 mg of the benzodiazepine antagonist RO 15-1788 on the ability to resist sleep and on mood of sleep deprived subjects. Repeated administration of 60 and 120 mg significantly increased subjects alertness in comparison with 5 mg and placebo. The 5 mg dose had a tendency to potentiate the hypnotic effects of sleep-deprivation. The higher levels of the drug also decreased positive mood and increased negative mood, and increased the density of sleep spindles during sleep. These results are interpreted to suggest a dose dependent effect of RO 15-1788 on arousal level.
mesh_terms: D000328:Adult; D001143:Arousal / Q000187:drug effects; D001569:Benzodiazepines / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D004644:Emotions / Q000187:drug effects / Q000502:physiology; D005442:Flumazenil / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D006990:Hypnosis; D008297:Male; D012892:Sleep Deprivation / Q000502:physiology*
chemical_list: D001569:Benzodiazepines; D005442:Flumazenil