Induction of platelet cytotoxic functions by lymphokines: role of interferon-gamma.
Antigen- or mitogen-stimulated CD4+/CD- lymphocytes produced factors able to induce normal human platelets into cytotoxic effectors toward the young larvae of Schistosoma mansoni. The neutralization by monoclonal anti-IFN-gamma antibody of the induction of the platelet killer effect, the presence of IFN-gamma in the CD4+/CD8- lymphocyte supernatant, and, finally, the direct inducer effect of recombinant IFN-gamma clearly demonstrated that IFN-gamma was one of the factors responsible for the induction of platelet cytotoxic functions.
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects* / Q000276:immunology; D003208:Concanavalin A / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism / Q000494:pharmacology*; D007814:Larva; D008213:Lymphocyte Activation / Q000187:drug effects; D008222:Lymphokines / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D012550:Schistosoma mansoni / Q000254:growth & development; D012555:Schistosomiasis mansoni / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification / Q000378:metabolism
D008222:Lymphokines; D003208:Concanavalin A; D007371:Interferon-gamma