title: Receptors for erythrogenic toxin A of Streptococcus pyogenes on human peripheral blood lymphocytes and other blood cells.
abstract: The binding of erythrogenic toxin A (ETA) of group A streptococci on human peripheral blood cells was demonstrated light- and electronmicroscopically by labelling with ETA-gold. Double labelling experiments of lymphocytes and the use of purified T-lymphocytes revealed that the ETA-receptor was confined to T cells. Besides lymphocytes, monocytes and especially granulocytes and thrombocytes showed a significant ETA-gold labelling. The lymphocyte ETA-receptor was found to be not sensitive to trypsin and neuraminidase and was not identical with the receptors for concanavalin A, Helix pomatia-lectin and sheep erythrocytes.
mesh_terms: D000328:Adult; D001426:Bacterial Proteins; D001792:Blood Platelets / Q000502:physiology* / Q000648:ultrastructure; D005098:Exotoxins / Q000378:metabolism*; D006098:Granulocytes / Q000502:physiology / Q000648:ultrastructure; D006651:Histocytochemistry; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D008565:Membrane Proteins; D008854:Microscopy, Electron; D011971:Receptors, Immunologic / Q000378:metabolism*; D013291:Streptococcus; D013601:T-Lymphocytes / Q000502:physiology* / Q000648:ultrastructure
chemical_list: D001426:Bacterial Proteins; D005098:Exotoxins; D008565:Membrane Proteins; D011971:Receptors, Immunologic; C117980:SpeA protein, Streptococcus pyogenes; C027951:erythrogenic toxin; C049791:erythrogenic toxin A receptor