High yield synthesis of 6-[18F]fluoro-L-dopa.
The radiofluorination of L-dopa with [18F]F2 was investigated with the purpose of improving the yield of 6-[18F]fluoro-L-dopa. When boron trifluoride was added to the reaction mixture in hydrogen fluoride (HF), the yield was increased threefold. Nine millicuries of 6-[18F]fluoro-L-dopa were produced from 100 mCi [18F]F2 routinely and reliably after 2 hr of preparation. If acetonitrile or water were substituted for HF, little or no 6-fluoro-L-dopa was made.
D001151:Arsenic; D001152:Arsenicals; D001880:Boranes; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D005459:Fluorides; D005461:Fluorine; D007536:Isomerism; D007553:Isotope Labeling / Q000379:methods*; D007980:Levodopa / Q000031:analogs & derivatives; D011868:Radioisotopes; D012821:Silanes; D017655:Silicon Compounds; D012997:Solvents
D001152:Arsenicals; D001880:Boranes; D011868:Radioisotopes; D012821:Silanes; D017655:Silicon Compounds; D012997:Solvents; D005461:Fluorine; C043437:fluorodopa F 18; D007980:Levodopa; D004295:Dihydroxyphenylalanine; C049321:silicon tetrafluoride; C021274:boron trifluoride; C049320:arsenic pentafluoride; C035420:levodopa methyl ester; D001151:Arsenic; D005459:Fluorides