Effects of phalloidin on platelet release.
The effect on platelet of phalloidin, a reagent forming phalloidin-actin polymer, was studied. Phalloidin suppressed ATP release but did not affect aggregation after the stimulation with ADP or A23187, although the amount of F-actin was increased by stimulation. The suppression was correlated to the preincubation time and to the concentration of phalloidin.
D000199:Actins / Q000097:blood; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000097:blood*; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D000001:Calcimycin / Q000494:pharmacology; D006801:Humans; D009842:Oligopeptides / Q000494:pharmacology*; D010590:Phalloidine / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects
D000199:Actins; D009842:Oligopeptides; D010590:Phalloidine; D000001:Calcimycin; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate