Serum thyroid hormones and thyroid hormone binding proteins in patients with completed stroke.
Thirty euthyroid patients hospitalized for completed stroke had serum thyroxine, triiodothyronine, thyroxine-binding globulin and thyroxine-binding prealbumin levels significantly decreased (p less than 0.01 to p less than 0.001) compared with 70 age- and sex-matched healthy controls. Admission serum thyroxine levels gave the best correlation with mortality (T4 less than 65 nmol/l = 100% mortality; 65-77 nmol/l = 38%; 78-90 nmol/l = 9%; greater than 90 nmol/l = 0%). In general, during hospitalization a progressive decrease in serum concentrations of these parameters was observed in the 11 patients who subsequently died, while there was a progressive increase in the 19 survivors. However, the most sensitive index of clinical recovery appeared to be prealbumin, since a decrease in prealbumin levels was observed in all subjects who died, and an increase in prealbumin was found in all survivors.
D000368:Aged; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D011228:Prealbumin / Q000378:metabolism*; D011379:Prognosis; D013974:Thyroxine / Q000097:blood*; D013975:Thyroxine-Binding Proteins / Q000378:metabolism*; D014284:Triiodothyronine / Q000097:blood*
D011228:Prealbumin; D013975:Thyroxine-Binding Proteins; D014284:Triiodothyronine; D013974:Thyroxine