[Congenital hypothyroidism. Current viewpoints and developments].
Since 1978 neonatal screening on congenital hypothyroidism (CHT) is performed in The Netherlands. A combined T4 and TSH determination is used. This creates the possibility to detect secondary and tertiary hypothyroidism. The number of false-positive cases is relatively high. This number decreases by adjusting the method of screening. Recent studies show a CHT incidence of 1:2100 newborns. In about 25% of these cases the CHT appears to be transient. Proceeding from the screening on CHT several investigations presented in this review are in progress.
D003409:Congenital Hypothyroidism; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy / Q000453:epidemiology; D007231:Infant, Newborn; D008403:Mass Screening; D009426:Netherlands; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use; D013975:Thyroxine-Binding Proteins / Q000032:analysis
D013975:Thyroxine-Binding Proteins; D013972:Thyrotropin; D013974:Thyroxine
Congenitale hypothyreoïdie. Nieuwe inzichten en ontwikkelingen.