title: Multiple central venous line occlusions following an error in parenteral nutrition formulation.
abstract: Multiple occlusions of central venous catheters occurred in four patients who were receiving total parenteral nutrition (TPN). Misformulation of bulk prepared TPN solution caused temperature-dependent precipitation of calcium phosphate within the catheter during infusion.
mesh_terms: D000368:Aged; D002130:Calcium Phosphates; D002408:Catheters, Indwelling; D011232:Chemical Precipitation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D012996:Solutions; D013696:Temperature
chemical_list: D002130:Calcium Phosphates; D012996:Solutions; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous