Influence of ofloxacin, norfloxacin, nalidixic acid, pyromidic acid and pipemidic acid on human gamma-interferon production and blastogenesis.
Several new quinolone derivatives were investigated for their influence on human lymphocyte blastogenesis and gamma-interferon production following concanavalin A stimulation. All the antimicrobials induced inhibition of lymphocyte DNA synthesis. The gamma-interferon measurements showed that nalidixic acid and norfloxacin have a negative influence on lymphokine production and release.
D000328:Adult; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009268:Nalidixic Acid / Q000494:pharmacology; D009643:Norfloxacin / Q000494:pharmacology; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology; D010876:Pipemidic Acid / Q000494:pharmacology; D010893:Piromidic Acid / Q000494:pharmacology
D000890:Anti-Infective Agents; D010078:Oxazines; D009268:Nalidixic Acid; D010893:Piromidic Acid; D007371:Interferon-gamma; D004247:DNA; D015242:Ofloxacin; D010876:Pipemidic Acid; D009643:Norfloxacin