[Effect of hyperosmolar glycerol, mannitol and sorbitol solutions on kidney function].
Changes of the renal function of a three-phase course originate from the application of hypertonic infusions. The first phase is characterized by a copious osmotic diuresis and the decrease of the re-absorption of osmotic free water. The second phase shows a lower osmotic diuresis and the re-absorption of osmotic free water attains the values before the beginning of the infusion. The third phase produces a urine time volume like before the infusion, however, the re-absorption of osmotic free water exceeds the starting-value. A biphasic course with isotonic electrolyte infusion is opposed to the three-phase course with osmotic load. Changes of the osmolarity in plasma and urine is to be recommended in order to take it into consideration more in the clinical practice.
D000818:Animals; D004231:Diuresis; D004285:Dogs; D004573:Electrolytes / Q000097:blood / Q000652:urine; D005990:Glycerol / Q000494:pharmacology*; D006982:Hypertonic Solutions; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007700:Kinetics; D008297:Male; D008353:Mannitol / Q000494:pharmacology*; D009994:Osmolar Concentration; D013012:Sorbitol / Q000494:pharmacology*; D014882:Water-Electrolyte Balance
D004573:Electrolytes; D006982:Hypertonic Solutions; D008353:Mannitol; D013012:Sorbitol; D005990:Glycerol
Der Einfluss hyperosmolarer Glyzerol-, Mannitol- und Sorbitollösungen auf die Nierenfunktion.