Effect of flavanone on mixed-function oxidase and conjugation reactions in rats.
Flavanone administered to female Fischer 344 rats (1.00 mmol/kg per day for seven days) did not induce ethylmorphine demethylation, aniline hydroxylation, hexobarbital oxidation or aldrin epoxidation. Flavanone at 0.05 mmol/kg per day for seven days increased glutathione-S-transferase activity with 1,2-dichloro-4-nitrobenzene and 1,2-epoxy-3-(p-nitrophenoxy) propane as substrates. Flavanone at 0.05 mmol/kg per day for seven days increased the glucuronidation of 1-naphthol, and at 0.20 mmol/kg increased the glucuronidation of chloramphenicol. Flavanone administration did not alter sulphotransferase activity with 2-naphthol as the substrate and did not enhance glutathione-S-transferase or glucuronyltransferase activity when added in vitro.
D000818:Animals; D001711:Biotransformation / Q000187:drug effects*; D044950:Flavanones; D005419:Flavonoids / Q000494:pharmacology*; D014453:Glucuronosyltransferase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D051381:Rats
D044950:Flavanones; D005419:Flavonoids; D006899:Mixed Function Oxygenases; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase; C028610:flavanone