Recombinant gamma interferon is a potent adjuvant for a malaria vaccine in mice.
Mice were protected against lethal Plasmodium yoelii malaria by vaccination with a Triton X-100 lysate of whole parasitized erythrocytes. For full effectiveness this vaccine required an adjuvant, and we have found that recombinant gamma-interferon has strong adjuvanticity in this model when given either intraperitoneally or subcutaneously. Specific immune responses that were enhanced included antibody, T cell help, and delayed hypersensitivity.
D000276:Adjuvants, Immunologic; D000818:Animals; D000941:Antigens / Q000627:therapeutic use*; D000953:Antigens, Protozoan / Q000627:therapeutic use*; D005260:Female; D000949:Histocompatibility Antigens Class II; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007371:Interferon-gamma / Q000276:immunology*; D008288:Malaria / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D011994:Recombinant Proteins / Q000276:immunology; D014614:Vaccines, Synthetic / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D000941:Antigens; D000953:Antigens, Protozoan; D000949:Histocompatibility Antigens Class II; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic; D007371:Interferon-gamma