title: Human immunoglobulin heavy-chain multigene deletions in healthy individuals.
abstract: Extensive multigene deletions have been described in the human immunoglobulin heavy-chain constant region genes, some of them encompassing perhaps more than 100 kilobases. These deletions have all been observed in healthy individuals although these individuals lacked several immunoglobulin class or subclasses, being either homozygous for one deletion or heterozygous for two different deletions. The high frequency of consanguinity in the Tunisian population accounts for the high frequency of individuals displaying one or the other of these deletions in a homozygous state.
mesh_terms: D002872:Chromosome Deletion; D002883:Chromosomes, Human, Pair 14; D004247:DNA / Q000235:genetics; D006801:Humans; D007070:Immunoglobulin A / Q000235:genetics / Q000276:immunology; D007127:Immunoglobulin Constant Regions / Q000235:genetics*; D007074:Immunoglobulin G / Q000235:genetics / Q000276:immunology; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007136:Immunoglobulins / Q000235:genetics*; D007153:Immunologic Deficiency Syndromes / Q000235:genetics; D009693:Nucleic Acid Hybridization; D014416:Tunisia
chemical_list: D007070:Immunoglobulin A; D007127:Immunoglobulin Constant Regions; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007136:Immunoglobulins; D004247:DNA