False-positive results with chemically modified anti-D.
Chemically modified anti-D typing serum is considered to combine the reliability of saline IgM anti-D with the convenience of slide and rapid tube anti-D. This has led to its wide acceptance in modern blood bank practice. False-positives are considered rare and are controlled by the ABO grouping. The extra step of an Rh control, which is necessary with IgG slide and rapid tube anti-D serums, is thus eliminated. However, this report shows that adopting this practice can be misleading and dangerous. Two cases are reviewed in which the chemically modified anti-D gave false-positive results and the ABO typing did not act as an adequate control.
D000368:Aged; D001787:Blood Group Incompatibility / Q000097:blood / Q000139:chemically induced*; D001788:Blood Grouping and Crossmatching; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D012204:Rh-Hr Blood-Group System
D012204:Rh-Hr Blood-Group System