Influence of accompanying anion on intestinal radiocalcium absorption.
To assess directly the effect of ionic dissociation on the bioavailability of calcium, we used the double isotope inverse convolution method to compare the absorption of calcium gluconate and calcium pyrrolidone carboxylate, an organic, highly dissociated salt. Two tests were performed at a 2 day interval, using in random sequence either salt as a carrier. Forty-eight subjects of various age and clinical condition were studied. The use of the more dissociated salt consistently and significantly increased fractional absorption in a rather constant ratio. Moreover, it slowed absorption in normal subjects whatever their age, and accelerated it in patients with chronic renal failure or osteoporosis, leading to inferences on the alteration of calcium absorption in these conditions.
D000328:Adult; D000368:Aged; D000375:Aging; D001682:Biological Availability; D002125:Calcium Gluconate / Q000378:metabolism*; D002132:Calcium Radioisotopes; D005260:Female; D005942:Gluconates / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000378:metabolism*; D011760:Pyrrolidinones / Q000378:metabolism*; D011761:Pyrrolidonecarboxylic Acid / Q000378:metabolism*; D013326:Strontium Radioisotopes
D002132:Calcium Radioisotopes; D005942:Gluconates; D011760:Pyrrolidinones; D013326:Strontium Radioisotopes; D002125:Calcium Gluconate; D011761:Pyrrolidonecarboxylic Acid