Treatment of pulmonary hypertension with transdermal nitroglycerin.
Glycerol trinitrate in patches (DEPONIT 10) resulted in a statistically significant pressure drop in the pulmonary artery, the pulmonary capillaries, and the right atrium within 24 hours following drug application. This pressure reduction was recorded also after 4 weeks of continuous therapy. The reduction of pulmonary artery pressure and pulmonary vascular resistance is not only a consequence of improved pre- and afterload, but in addition also of a decrease in airways resistance and direct influence on arteriolar constriction in the pulmonary vascular bed. The beneficial effects upon pulmonary haemodynamics were equally recorded several months later.
D000279:Administration, Cutaneous; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage*; D014655:Vascular Resistance / Q000187:drug effects
D005996:Nitroglycerin