Fibronectin levels in stressed and septic patients fed with total parenteral nutrition.
Plasma fibronectin concentrations were measured in healthy persons as well as in septic and stressed patients. A decrease in plasma fibronectin concentration was shown in volunteers receiving a low energy (600 kcal), amino acids- and lipid-deficient diet. Increased fibronectin levels were measured in stressed and septic patients, not receiving enteral nutrition, after adequate total parenteral nutrition (TPN during 1 week). It is concluded that total parenteral nutrition facilitates improved fibronectin synthesis in stressed and septic patients. Total parenteral nutrition containing an amino acid mixture rich in branched amino acids (50.2% BCAA) is not superior to TPN containing a standard amino acid mixture (15.6% BCAA) in this respect.
D000328:Adult; D000597:Amino Acids, Branched-Chain / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005353:Fibronectins / Q000096:biosynthesis / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D018805:Sepsis / Q000097:blood*; D013315:Stress, Psychological / Q000097:blood*; D014947:Wounds and Injuries / Q000097:blood
D000597:Amino Acids, Branched-Chain; D005353:Fibronectins; D002097:C-Reactive Protein