title: Partial response of meningeal myeloma to craniospinal radiotherapy.
abstract: Concomitant occurrence of meningeal involvement and thoracic plasmacytoma was observed in a patient with IgA lambda myeloma. Cerebrospinal fluid analysis revealed IgA-lambda paraprotein and pathological plasma cells. CT scan of the chest and lumbar myelogram excluded spinal cord compression. The patient partially responded to craniospinal irradiation but succumbed to rapidly progressive myeloma 20 weeks following diagnosis of meningeal involvement.
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology; D007070:Immunoglobulin A / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid / Q000532:radiotherapy* / Q000556:secondary; D009101:Multiple Myeloma / Q000134:cerebrospinal fluid / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D007070:Immunoglobulin A; D007146:Immunoglobulin lambda-Chains