Autonomous ovarian hyperfunction followed by gonadotrophin-dependent puberty in McCune-Albright syndrome.
A 5-year-old girl with the McCune-Albright syndrome presented with precocious puberty secondary to autonomously functioning ovarian cysts, followed by true central puberty. Progression from gonadotrophin-independent to gonadotrophin-dependent precocious puberty may occur from elevated sex steroid levels leading to the early maturation of the hypothalamic-pituitary axis.
D002675:Child, Preschool; D004958:Estradiol / Q000097:blood; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000503:physiopathology*; D005359:Fibrous Dysplasia, Polyostotic / Q000097:blood / Q000503:physiopathology*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D010053:Ovary / Q000473:pathology / Q000503:physiopathology*; D011627:Puberty; D011629:Puberty, Precocious / Q000503:physiopathology*; D012880:Skin Pigmentation; D014463:Ultrasonography
D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone