Bio-antimutagenic effect of L-cysteine on diiodohydroxyquinoline-induced micronuclei in Swiss mice.
The mutagenic potential of diiodohydroxyquinoline (DIHQ), a common anti-amebic drug, was tested using the in vivo micronucleus test in Swiss mice following oral administration. It was found to be mutagenic in a dose-dependent manner. Using the same model system, the bio-antimutagenic effect of the sulfhydryl compound L-cysteine against DIHQ was established.
D000284:Administration, Oral; D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure; D002467:Cell Nucleus / Q000187:drug effects* / Q000648:ultrastructure; D003545:Cysteine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000648:ultrastructure; D006912:Hydroxyquinolines / Q000494:pharmacology*; D004103:Iodoquinol / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D009152:Mutagenicity Tests; D009154:Mutation
D006912:Hydroxyquinolines; D004103:Iodoquinol; D003545:Cysteine