Interferon blocks interleukin 1-induced prostaglandin release from human peripheral monocytes.
We have studied the short-term effects of interleukin 1, lipopolysaccharide, and interferon on prostaglandin release from freshly isolated human peripheral monocytes. When the cells were pretreated for 8 to 9 hr with either E. coli lipopolysaccharide or recombinant interleukin 1 (beta), prostaglandin release increased. Inclusion of recombinant IFN-alpha or IFN-gamma during the pretreatment phase blocked subsequent prostaglandin release. Interferons were effective at concentrations in the range of 1 to 10 antiviral units/ml, and the inhibition was manifested within several hours after exposure to the lymphokine. Similar trends were observed by measuring thromboxane release. These data suggest antagonistic roles for interleukin 1 and interferon in the regulation of eicosanoid release from monocytes.
D003165:Complement System Proteins / Q000502:physiology; D015232:Dinoprostone; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007370:Interferon Type I / Q000502:physiology*; D007371:Interferon-gamma / Q000502:physiology*; D007375:Interleukin-1 / Q000037:antagonists & inhibitors*; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000502:physiology; D009000:Monocytes / Q000502:physiology*; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology; D013929:Thromboxane B2 / Q000378:metabolism
D007370:Interferon Type I; D007375:Interleukin-1; D008070:Lipopolysaccharides; D011453:Prostaglandins; D011458:Prostaglandins E; D011994:Recombinant Proteins; D013929:Thromboxane B2; D007371:Interferon-gamma; D003165:Complement System Proteins; D015232:Dinoprostone