Determinants of response to eucapneic hyperventilation with cold air in a population-based study.
A population-based, epidemiologic investigation conducted in children, adolescents, and young adults analyzed the response to eucapneic hyperventilation with cold air as a continuous variable to better define factors that influence the expression of bronchial responsiveness. Among respiratory illness/symptom variables, only the report of asthma or persistent wheeze in the previous year and the report of a respiratory illness that led to activity restriction were significantly associated with response to cold air. Furthermore, a low, prechallenge FEF/FVC ratio was a significant predictor of response, especially among those subjects who reported a respiratory illness that led to activity restriction. This relationship was not observed for a low prechallenge FEF.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001249:Asthma / Q000503:physiopathology; D001980:Bronchi / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D002245:Carbon Dioxide / Q000097:blood; D002648:Child; D003080:Cold Temperature; D005260:Female; D005540:Forced Expiratory Flow Rates; D006801:Humans; D006985:Hyperventilation / Q000097:blood / Q000503:physiopathology*; D008297:Male; D012140:Respiratory Tract Diseases / Q000503:physiopathology; D012737:Sex Factors; D012907:Smoking; D014797:Vital Capacity
D002245:Carbon Dioxide