title: Fibrinogen content of low-volume cryoprecipitate.
abstract: Single-donor cryoprecipitate is the most convenient and reliable source of fibrinogen. A change by the regional Red Cross Blood Service to the production of low-volume cryoprecipitate led the authors to reexamine the fibrinogen content of cryoprecipitate units. The average fibrinogen content of individual low-volume (4 ml) units (n = 23) was 101 +/- 48 mg; in the 10-unit pools (n = 9 pools), content was 89 +/- 13 mg. Both measurements were considerably lower than previously published. By contrast, the mean fibrinogen content of regular-volume (15 ml) cryoprecipitate units (n = 8) was 142 +/- 50 mg. The fibrinogen was stable for at least 4 hours after thawing, and it survived refreezing and thawing.
mesh_terms: D001771:Blood Banks; D003080:Cold Temperature; D005169:Factor VIII / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D010949:Plasma / Q000032:analysis; D011786:Quality Control
chemical_list: D005169:Factor VIII; D005340:Fibrinogen