title: [Prevention trials and role of vascular factors in moderate arterial hypertension].
abstract: Epidemiological studies on the treatment of moderate arterial hypertension show little change in the frequency of coronary disease despite a significant lowering of arterial pressure. This phenomenon reflects the causative role played by alterations of the main arteries in the cardiovascular morbidity and mortality of treated hypertensive patients. These alterations may be of different natures, notably haemodynamic (increased arterial rigidity) or biochemical (especially changes in lipid profile). Seen from that angle, involvement of the main arteries reflects either an arterial wall pathology specific to the hypertensive disease, or an associated atherosclerosis, or the effect of certain drugs. The role of each of these factors is described.
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001158:Arteries / Q000378:metabolism; D003327:Coronary Disease / Q000209:etiology / Q000517:prevention & control*; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008055:Lipids / Q000097:blood
chemical_list: D000959:Antihypertensive Agents; D008055:Lipids
vernacular_title: Essais de prévention et rôle des facteurs vasculaires dans l'hypertension artérielle modérée.