Effects of onion extract on the development of hamster buccal pouch carcinomas as expressed in tumor burden.
One-hundred male, young-adult Syrian hamsters (Mesocricetus auratus) were divided into five equal groups of 20 animals each. Groups 1, 2, and 3 were painted three times a week in the left buccal pouches with a 0.5% solution of 7,12-dimethylbenz[a]anthracene (DMBA) in mineral oil. Group 1 animals also received a 20% onion extract in their drinking water and were also painted in left buccal pouches three times a week with a 50% onion extract in mineral oil. Group 2 animals received the onion extract in their drinking water, but they received only mineral oil in buccal pouches as a control for the painting with onion extract in mineral oil. Group 3 animals received DMBA but no onion extract. Group 4 animals received onion extract but no DMBA, and Group 5 animals were left untreated. Onion extract was found to significantly delay tumor formation in Groups 1 and 2 compared with Group 3 DMBA controls.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000490:Allium / Q000032:analysis; D000818:Animals; D002277:Carcinoma / Q000517:prevention & control*; D002610:Cheek; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D009062:Mouth Neoplasms / Q000517:prevention & control*; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology
D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene