Plipastatins: new inhibitors of phospholipase A2, produced by Bacillus cereus BMG302-fF67. I. Taxonomy, production, isolation and preliminary characterization.
Plipastatins have been isolated as part of a program designed to find inhibitors of porcine pancreatic phospholipase A2. They were purified from fermentation broth of Bacillus cereus BMG302-fF67 and finally separated into four fractions by reverse phase HPLC. The respective fractions were designated as plipastatins A1, A2, B1 and B2. Plipastatins also inhibited phospholipases C and D.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001409:Bacillus cereus / Q000145:classification* / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D005227:Fatty Acids / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D009842:Oligopeptides / Q000302:isolation & purification* / Q000494:pharmacology; D010456:Peptides, Cyclic; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2
D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D009842:Oligopeptides; D010456:Peptides, Cyclic; C049901:plipastatin; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2