Association of prostaglandin metabolism with urine volume; dissociation from excretion of Na+ and K+ by stress.
Stress induced by routine cage cleaning causes retention of Na+ and K+, and increased water and prostaglandin metabolite excretion when measured either against concurrent-controls or against self-control values. This novel stress completely masked the diuretic effects of a long-acting prostaglandin synthetase inhibitor previously observed in a stress-free environment. The results show that prostaglandin synthesis and urine volume regulation are closely associated. They also demonstrate a complete dissociation of urine volume and prostaglandin synthesis regulation from electrolyte regulatory mechanisms in a stressful environment.
D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D000527:Alprostadil / Q000494:pharmacology / Q000502:physiology; D000822:Animal Husbandry; D000818:Animals; D016861:Cyclooxygenase Inhibitors; D004231:Diuresis / Q000187:drug effects*; D008297:Male; D011188:Potassium / Q000652:urine; D011453:Prostaglandins / Q000378:metabolism* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine; D013148:Spironolactone / Q000494:pharmacology / Q000502:physiology; D013312:Stress, Physiological / Q000503:physiopathology*; D014556:Urine
D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D013148:Spironolactone; C045515:2-methyl-8,12,14-eicosatrienoic acid; D012964:Sodium; D000527:Alprostadil; D015126:8,11,14-Eicosatrienoic Acid; D011188:Potassium