Differences in the ability of salbutamol to prevent and reverse LTC4-induced contractions of the guinea-pig isolated trachea: influence of l-serine borate.
In the presence of l-serine borate, salbutamol was much more effective in reversing rather than preventing LTC4-induced contractions of guinea-pig trachea. This suggests that different mechanisms are involved in initiating versus maintaining LTC4-induced contractions. In addition, the ability of salbutamol pretreatment to prevent LTC4-induced contractions was reduced substantially in the presence of l-serine borate, suggesting that the metabolites of LTC4 (LTD4 and LTE4) are more sensitive to inhibition by beta-adrenoceptor agonists than is LTC4 itself.
D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D001881:Borates / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D013189:SRS-A / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D012694:Serine / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects* / Q000502:physiology
D001881:Borates; D013189:SRS-A; C040900:serine-borate complex; D012694:Serine; D000420:Albuterol