title: Changes of free histones in chick testicular and ovarian cells after embryonic and/or neonatal treatment with diethylstilbestrol (DES) or allyloestrenol (AE).
abstract: DES and AE when injected into the yolk sac of chick embryos on the 9th day of incubation decreased the neonatal weight of the testis and the PMB-reaction of spermatogonia whereas they increased the neonatal weight and granulosa cell PMB-reaction of the ovary. In the ovary, embryonic treatment increased the efficiency of post-hatching hormone treatments.
mesh_terms: D000367:Age Factors; D000500:Allylestrenol / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004963:Estrenes / Q000494:pharmacology*; D005260:Female; D006107:Granulosa Cells / Q000166:cytology / Q000378:metabolism; D006657:Histones / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013093:Spermatogonia / Q000166:cytology / Q000378:metabolism; D013737:Testis / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D015017:Yolk Sac / Q000378:metabolism
chemical_list: D004963:Estrenes; D006657:Histones; D004054:Diethylstilbestrol; D000500:Allylestrenol