Cells infiltrating human periapical inflammatory lesions.
Cells infiltrating human periapical granulomas and cysts were analyzed using cell suspensions. Over 50% of the total cells studied were lymphocytes whilst neutrophils were the next most frequent cell type observed. Two percent of the cells were mast cells. Only a few monocytes/macrophages and natural killer cells were found. More than half of the lymphocytes infiltrating the lesions were T cells, and more than half of the T cells were of the suppressor/cytotoxic (OKT8) phenotype. The OKT4/OKT8 ratio was 0.5. The findings are compared to previous reports and the differences discussed.
D000328:Adult; D000911:Antibodies, Monoclonal; D004804:Eosinophils / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008214:Lymphocytes / Q000145:classification / Q000473:pathology*; D008264:Macrophages / Q000473:pathology; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology; D010484:Periapical Granuloma / Q000473:pathology*; D010950:Plasma Cells / Q000473:pathology; D011842:Radicular Cyst / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology
D000911:Antibodies, Monoclonal