[Oral long-term tocolysis of threatened premature labor using clenbuterol (Contraspasmin, Spiropent). A placebo-controlled double-blind method].
In quest of a efficacious oral tocolysis drug for inhibition the preterm labour we used in a randomised study the betamimeticum Clenbuterol or placebo with 1 tablet 3 times daily (3 X 0.02 mg/d Clenbuterol) in a total number of 109 patients. In result we can't see any significant distinction in gestational age and birth weight at delivery time and in duration of therapy up to delivery between the two groups. For that reason we are of the opinion, that a fundamental influence of Clenbuterol on premature birth cannot be expected.
D000284:Administration, Oral; D002976:Clenbuterol / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008134:Long-Term Care; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy
D004983:Ethanolamines; D002976:Clenbuterol
Orale Langzeittokolyse der drohenden Frühgeburt mit Clenbuterol (Contraspasmin, Spiropent). Eine plazebokontrollierte Doppelblindstudie.