[Current status of somatocrinin, or GRF, a hypothalamic growth hormone-secreting factor].
This short review on GRF is divided into two parts: laboratory findings: Current status of the knowledge on the primary structure of all the GRFs isolated from mammalian sources; structure activity relationships as obtained with synthetic fragments and analogs of GRF; the mechanisms of action of GRF in vitro and in vivo; the localization by techniques of hypothalamic GRF neurons.


METHODS
A summary of past and current clinical studies with hGRF or fragments of hGRF establishing the dose range/effect in normal young adults; pharmacokinetics of hGRF; intravenous, sub-cutaneous and intranasal modes of administration; multi hours perfusions; the use of hGRF alone and in combination with other releasing factors as a diagnostic tool; early clinical results of stimulation of statural growth. Limited bibliography.
D000818:Animals; D006130:Growth Disorders / Q000188:drug therapy; D013007:Growth Hormone-Releasing Hormone / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism*; D007700:Kinetics; D010446:Peptide Fragments / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use; D013045:Species Specificity; D013329:Structure-Activity Relationship
D010446:Peptide Fragments; D013007:Growth Hormone-Releasing Hormone
Etat actuel de la somatocrinine, ou GRF, facteur hypothalamique de sécrétion de l'hormone de croissance.