Direct and cell-mediated effects of interferon-alpha and -gamma on cells chronically infected with HTLV-III.
The replication of the human T lymphotropic retrovirus HTLV-III in persistently infected cells is relatively insensitive to the direct antiviral action of human interferon-alpha or -gamma (IFN-alpha or -gamma), showing only a two- to threefold reduction of HTLV-III, even though the host cells are very sensitive to IFN, as shown by vesicular stomatitis virus (VSV)-yield reduction assay (4-5 log reduction of VSV). However, IFN anticellular activity is strongly enhanced in the presence of normal peripheral blood mononuclear cells, suggesting a cell-mediated effect of IFNs.
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D002460:Cell Line; D002478:Cells, Cultured; D006678:HIV / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007157:Immunologic Surveillance / Q000187:drug effects*; D007370:Interferon Type I / Q000276:immunology / Q000494:pharmacology*; D007371:Interferon-gamma / Q000276:immunology / Q000494:pharmacology*; D008211:Lymphocyte Cooperation; D008214:Lymphocytes / Q000276:immunology / Q000502:physiology; D011994:Recombinant Proteins / Q000276:immunology; D014779:Virus Replication / Q000187:drug effects
D007370:Interferon Type I; D011994:Recombinant Proteins; D007371:Interferon-gamma