title: Benzothiazolium salts--relationships between their structure, toxicity and effect on the plastid system of Euglena gracilis.
abstract: The effects of 41 benzothiazolium salts on Euglena gracilis were characterized with regard to the influence on growth and on chlorophyll synthesis, and to their ability to induce permanent loss of chloroplasts. Some salts induced white mutants of E. gracilis (the first benzothiazole derivatives with this activity). The relationship between the biological effect and chemical structure was confirmed and expressed quantitatively by means of Free - Wilson and Fujita - Ban analysis.
mesh_terms: D000818:Animals; D002734:Chlorophyll / Q000096:biosynthesis; D002736:Chloroplasts / Q000187:drug effects; D005056:Euglena gracilis / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D013844:Thiazoles; D002734:Chlorophyll