title: Defects in cell-mediated immunity.
abstract: Defects in cell-mediated immunity result in remarkable susceptibility to opportunistic infection in contrast to the recurrent pyogenic infections observed in children with defects in antibody-mediated immunity. The major congenital defects in T lymphocytes are presented.
mesh_terms: D000243:Adenosine Deaminase / Q000172:deficiency; D001260:Ataxia Telangiectasia / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004062:DiGeorge Syndrome / Q000276:immunology; D004198:Disease Susceptibility; D006801:Humans; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000151:congenital / Q000201:enzymology / Q000276:immunology*; D007223:Infant; D007231:Infant, Newborn; D007239:Infections / Q000209:etiology; D011683:Purine-Nucleoside Phosphorylase / Q000172:deficiency; D013601:T-Lymphocytes / Q000276:immunology; D014923:Wiskott-Aldrich Syndrome / Q000276:immunology
chemical_list: D011683:Purine-Nucleoside Phosphorylase; D000243:Adenosine Deaminase