title: [Kinetics of germ killing and damage to selected bacterial enzymes by thermal and chemical influences. I. Theoretical background of killing and enzyme inhibition kinetics].
abstract: Thermal and chemical influences on microorganisms and the kinetics of microbicidal processes are described in terms suitable to define the resistance of microbes to heat and disinfectants resp. sterilisants. Interactions between active substances (e.g. disinfectants) and enzymes are formulated in equations, and the parameters of kinetics of inactivating enzymes (e.g. Ki-values) are derived. They permit a gradual evaluation of efficacy of microbicidal agents irrespective of their concentration.
mesh_terms: D001419:Bacteria / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D004202:Disinfectants / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004791:Enzyme Inhibitors; D006358:Hot Temperature; D006801:Humans; D007700:Kinetics; D008433:Mathematics
chemical_list: D004202:Disinfectants; D004791:Enzyme Inhibitors
vernacular_title: Zur Kinetik der Keimtötung und der Schädigung ausgewählter bakterieller Enzyme durch thermische und chemische Einwirkungen. I. Mitteilung: Theoretische Grundlagen der Abtötungs- und Enzymhemmungskinetik.