Effects of bacterial sepsis on protein metabolism in infants during the first week.
In the presence of bacterial infection during the first week of life a catabolic state evolves more rapidly than in the later life. Hyperaminoacidaemia and subsequent hyperaminoaciduria, elevated urea concentrations in serum, and increased renal nitrogen losses are the most important metabolic changes. These findings correlate with the clinical course of the disease and refer to the primary disturbance of cell metabolism as the cause of the metabolic changes observed. While no relation could be observed between metabolic response and bacterial species, there is a significant dependence on the time interval from the occurrence of first clinical symptoms at the beginning of antibiotic treatment. If this period is longer than 8 h, serious metabolic disturbances will usually be found. Due to the limited amino acids utilization, especially by the liver, an adequate energy intake should be the primary aim of nutrition, whereas a protein intake of more than 2.0 to 2.5 g/kg X day may further aggravate the metabolic imbalance.
D001424:Bacterial Infections / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D009584:Nitrogen / Q000097:blood / Q000652:urine; D010289:Parenteral Nutrition, Total; D011506:Proteins / Q000378:metabolism*; D012127:Respiratory Distress Syndrome, Newborn / Q000378:metabolism; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D011506:Proteins; D014508:Urea; D009584:Nitrogen