Classical conditioning of amphetamine-induced lateralized and nonlateralized activity in rats.
Amphetamine-induced lateralized activity (rotation) and nonlateralized activity (extra quarter turns) was classically conditioned in female rats using the test environment as the conditioned stimulus (CS) and 1.25 mg/kg d-amphetamine as the unconditioned stimulus. Conditioned lateralized activity extinguished more rapidly than nonlateralized activity. Also, d-amphetamine-induced nonlateralized activity was selectively decreased by a schedule of 50% partial reinforcement. These results indicate that the two d-amphetamine responses can be distinguished, that they are differentially affected by learning, and that a schedule of partial reinforcement can selectively attenuate one effect of a drug while leaving the other intact. In addition, haloperidol blocked conditioned lateralized activity; this suggests that the conditioned response may be, like the drug-induced response, mediated by dopamine.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D012055:Reinforcement Schedule
D000661:Amphetamine; D006220:Haloperidol