The effect of sympathetic denervation with 6-hydroxydopamine on the ventral prostate of the rat.
The effect of chemical sympathectomy with 6-hydroxydopamine (6-OHDA) on the ventral prostate of the rat was studied. A dose of 50 mg/kg i.v., which was repeated after 1 week, was effective enough to produce total disappearance of sympathetic nerves. Reappearance of nerve fibres was evident 2 weeks after treatment. Dilation of prostatic alveoli was noted 1 week after denervation. It is concluded that the absence of normal sympathetic innervation prevents the emptying of the rat prostate.
D000818:Animals; D006892:Hydroxydopamines; D008297:Male; D008856:Microscopy, Fluorescence; D016627:Oxidopamine; D011467:Prostate / Q000166:cytology / Q000294:innervation*; D051381:Rats; D011919:Rats, Inbred Strains; D013563:Sympathectomy, Chemical
D006892:Hydroxydopamines; D016627:Oxidopamine