Effects of weekly and daily pretreatment with gold sodium thiomalate on adjuvant induced arthritis.
The effect of gold sodium thiomalate on adjuvant induced arthritis in DA rats was investigated. Ten mg/kg gold given in either weekly or daily injections before the administration of adjuvant was able to decrease the severity of arthritis in these animals. One mg/kg gold given as daily injections had no effect on adjuvant induced arthritis. One mg/kg gold given as weekly injections before adjuvant administration reduced the severity of arthritis to a level which was intermediate between that seen in the placebo control and the 10 mg/kg gold groups. The proliferative responses of spleen cells to mitogens in these animals were not altered by in vivo gold therapy.
D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D004334:Drug Administration Schedule; D005260:Female; D005620:Freund's Adjuvant; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D011859:Radiography; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000378:metabolism / Q000473:pathology; D013936:Thymidine / Q000378:metabolism
D006052:Gold Sodium Thiomalate; D005620:Freund's Adjuvant; D013936:Thymidine