[Various enzymatic activities in gastric carcinoma and intestinal metaplasia].
Blood enzymatic activities in gastric carcinoma depend on the release from carcinomatous tissues, surrounding non-neoplastic tissues, increased permeability and necrosis of carcinomatous tissues. However, those enzymatic activities did not parallel the extent and macroscopic appearance of the tumor. Various enzyme proteins and gastrointestinal hormones concerning gastric carcinoma and intestinal metaplasia including pepsin, LDH, AFP, beta-glucuronidase, rGTP, lysozyme, ferritin, sialic acid, polyamine, CEA, Ca 19-9, collage, gastrin, immunoglobulin are discussed in this paper. The variation of enzymes and proteins occurring in gastric carcinoma and intestinal metaplasia are well documented. Some of them would be a useful indicator of diagnosis and treatment as a tumor marker.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000951:Antigens, Neoplasm / Q000032:analysis; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003094:Collagen / Q000032:analysis; D005753:Gastric Mucosa / Q000473:pathology*; D005755:Gastrins / Q000032:analysis; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008679:Metaplasia / Q000201:enzymology; D010434:Pepsin A / Q000378:metabolism; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000276:immunology
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen; D005755:Gastrins; D007136:Immunoglobulins; D003094:Collagen; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase; D005966:Glucuronidase; D010434:Pepsin A