Chronic immunization of endogenous thyrotrophin-releasing hormone (TRH) in brain alters the behavioural response to pentobarbital and a TRH analogue.
Rats were infused with purified thyrotrophin-releasing hormone (TRH) anti-serum i.c.v. for two weeks and the reversal of pentobarbital-induced anaesthesia, hypothermia and respiratory depression by central administration of a TRH analogue (CG 3509) was measured. After antibody infusion the anaesthesia time was more than doubled but the responses to CG 3509 were increased, suggesting a role for endogenous TRH in arousal mechanisms which is sensitized following chronic immunological blockade.
D000768:Anesthesia, General; D000818:Animals; D001143:Arousal / Q000502:physiology; D001831:Body Temperature / Q000187:drug effects; D007106:Immune Sera / Q000494:pharmacology*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D012119:Respiration / Q000187:drug effects; D012688:Septum Pellucidum / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000276:immunology* / Q000494:pharmacology / Q000502:physiology
D007106:Immune Sera; C036430:orotirelin; D013973:Thyrotropin-Releasing Hormone; D010424:Pentobarbital