Differential and asymmetrical behavioral effects of electrolytic or 6-hydroxydopamine lesions in the nucleus accumbens.
Sprague-Dawley rats received either unilateral or bilateral electrolytic or 6-hydroxydopamine (6-OHDA) lesions in the nucleus accumbens (n. acc.) and daily spontaneous activity was measured in home cage running wheels for 30 days postoperatively. Bilateral electrolytic lesions increased activity to 230% of preoperative baseline. Right electrolytic lesions produced a 50% increase in activity while left lesion rats were not significantly different from sham-operated controls. Conversely, 6-OHDA lesions depressed activity. Bilateral 6-OHDA lesions had the greatest depressant effect upon activity while unilateral left or right n. acc. treatments produced relatively less hypoactivity. Results support an asymmetrically organized serial inhibition model of spontaneous locomotor control.
D000818:Animals; D001931:Brain Mapping; D004298:Dopamine / Q000502:physiology; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000502:physiology*
D006892:Hydroxydopamines; D016627:Oxidopamine; D004298:Dopamine