[Effect of antioxidants on the activity of liver glutathione-S-, glucuronyl- and sulfurtransferases in rats].
It was shown that pretreatment of rats with antioxidants (AO) butylhydroxytoluene and 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride owing to its effect of animal protection against intoxication with diethylnitrosamine (DENA) increases the liver activity of enzymes of stage II metabolism of xenobiotics: glutathione-S-transferase (GST), UDP-glucuronyltransferase (UDP-GT). Administration of DENA (LD50) produced a significant decrease of the activity of GST and UDP-GT as compared with that in intact animals. At the same time its action on the animals pretreated with AO develops against the background of increased activity of these enzymes.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D004052:Diethylnitrosamine / Q000633:toxicity; D004789:Enzyme Activation / Q000187:drug effects; D014453:Glucuronosyltransferase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010847:Picolines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013466:Sulfurtransferases / Q000378:metabolism*
D000975:Antioxidants; D010847:Picolines; D002084:Butylated Hydroxytoluene; D004052:Diethylnitrosamine; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase; D013466:Sulfurtransferases; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Vliianie antioksidantov na aktivnost' glutation-S-, gliukuronil- i sul'fotransferaz pecheni krys.