High serum levels of soluble interleukin-2 receptors in sarcoidosis.
We provide evidence that high levels of soluble interleukin-2 receptor (sIL-2R) are present in the serum of patients with sarcoidosis. Because sIL-2R is capable of binding to its ligand (IL-2), the increased serum levels of this molecule could induce a starvation of IL-2. This mechanism could help to explain a number of immunological abnormalities extensively reported in these patients and generally attributed to not yet identified serum inhibitory factors.
D000328:Adult; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000032:analysis*; D008171:Lung Diseases / Q000097:blood*; D008297:Male; D011971:Receptors, Immunologic / Q000032:analysis; D015375:Receptors, Interleukin-2; D012507:Sarcoidosis / Q000097:blood*; D012995:Solubility
D007376:Interleukin-2; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2