Appearance of light chain disease in serum electrophoresis. Report of 11 cases.
Over a five year period, 13 cases of light chain disease were identified. Ten patients had abnormalities noted on serum immunoelectrophoresis with anti-whole-human antiserum. Eight of these ten patients had a distinctive rainbow-like arc between the IgG and transferrin arcs, and two had splitting of the IgG arc. These patterns may be seen in the presence of free light chains; their recognition should lead to further studies with appropriate antisera.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D007074:Immunoglobulin G / Q000032:analysis; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood*
D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains