title: Bupropion. Effects on cerebral monoamines in rat and on blood pressure in dog.
abstract: Intravenous injections of bupropion into the femoral vein of dogs did not change cardiovascular peripheric responses because it did not affect significantly either arterial pressure or heart rate. In acute experiments bupropion increased the levels of DA, NA and 5-HT in the brain of rats. There was a remarkable correlation between the levels of monoamines and the hypermotility.
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D016642:Bupropion; D004285:Dogs; D004558:Electric Stimulation; D005968:Glutamate Decarboxylase / Q000378:metabolism; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011427:Propiophenones / Q000494:pharmacology*; D051381:Rats; D013045:Species Specificity; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D001679:Biogenic Amines; D011427:Propiophenones; D016642:Bupropion; D005680:gamma-Aminobutyric Acid; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase