[Mediated action of phytogenic antineoplastic agents on rats with Pliss lymphosarcoma].
The action of drugs of plant origin and of alkylating compounds (sarcolysine, prospidin) was accompanied by hormonal changes in rats with inoculated Pliss' lymphosarcoma. After the use of polyphenol plant drugs the secretion of pituitary FSH was inhibited, the blood concentration of testosterone was reduced and the cortisol secretion was substantially increased. The alkylating compounds stimulated the production of FSH, increased the secretion of testosterone, and clearly lowered the cortisol level.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D005419:Flavonoids; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006854:Hydrocortisone / Q000097:blood; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D051379:Mice; D010636:Phenols / Q000494:pharmacology*; D010902:Pituitary Gland / Q000378:metabolism; D011108:Polymers / Q000494:pharmacology*; D059808:Polyphenols; D051381:Rats; D013739:Testosterone / Q000097:blood
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D013739:Testosterone; D005640:Follicle Stimulating Hormone; D006854:Hydrocortisone
Oposredovannoe deĭstvie nekotorykh protivoopukholevykh preparatov rastitel'nogo proiskhozhdeniia na krys s limfosarkomoĭ Plissa.