Antimutagenic properties of lactic acid-cultured milk on chemical and fecal mutagens.
The antimutagenic properties of milk cultured with Lactobacillus bulgaricus and Streptococcus thermophilus were examined using streptomycin-dependent strains of Salmonella in an in vitro assay system. The mutagens utilized for testing included 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide, 4-nitroquinoline-N-oxide, and fecal mutagenic extracts from cats, monkeys, dogs, and other mammals. Both types of cultured milk exhibited antimutagenic activity on all mutagens used. Antimutagenic activities of the cultured milks with 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide and 4-nitroquinoline-N-oxide increased with incubation time but were thermolabile beyond 55 degrees C for 10 min.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D000818:Animals; D002415:Cats; D002417:Cattle; D004285:Dogs; D005243:Feces; D000882:Haplorhini; D066298:In Vitro Techniques; D007778:Lactobacillus; D008892:Milk / Q000502:physiology*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D009581:Nitrofurans / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000187:drug effects*; D013291:Streptococcus
D009153:Mutagens; D009581:Nitrofurans; D015112:4-Nitroquinoline-1-oxide