[Polyamine levels and diamine oxidase activity in the rat liver and kidneys during hepatocarcinogenesis induced by N-nitrosodiethylamine].
Changes in the polyamine metabolism in the liver and kidneys have been studied in rats with N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis and under diethylamine administration. It is found that the intracellular content of polyamines rises and the diaminooxidase activity falls in the liver (but not in the kidneys) of rats who were given NDEA in drinking water. These changes are most pronounced during the first month of carcinogenesis and in the induced tumours. It is a typical (though not specific) biochemical peculiarity of hepatocarcinogenesis.
D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism*; D000818:Animals; D004048:Diethylamines; D004052:Diethylnitrosamine; D007668:Kidney / Q000201:enzymology / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D011073:Polyamines / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism; D051381:Rats; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism
D004048:Diethylamines; D011073:Polyamines; D013096:Spermine; D004052:Diethylnitrosamine; C034281:diethylamine; D006631:Amine Oxidase (Copper-Containing); D013095:Spermidine; D011700:Putrescine
Soderzhanie poliaminov i aktivnost' diaminooksidazy v pecheni i pochkakh krys pri gepatokantserogeneze, indutsirovannom N-nitrozodiétilaminom.