Ciprofloxacin interactions with imipenem and amikacin against multiresistant Pseudomonas aeruginosa.
In vitro interactions of ciprofloxacin with imipenem and amikacin were evaluated by the killing-curve technique against 26 Pseudomonas aeruginosa strains resistant to amikacin and resistant or moderately susceptible to ciprofloxacin and imipenem. Imipenem enhanced killing by ciprofloxacin in tests with 11 strains, whereas amikacin enhanced killing in tests with only 4 strains.
D000583:Amikacin / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D015378:Imipenem; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013845:Thienamycins / Q000494:pharmacology*
D013845:Thienamycins; D002939:Ciprofloxacin; D015378:Imipenem; D000583:Amikacin