title: Detection of anti-histone activity in sera of patients with monoclonal gammopathies.
abstract: Sera from 249 patients with monoclonal gammopathies (85 multiple myeloma, 92 benign monoclonal gammopathies, 53 cryoglobulinemia, 19 Waldenström's macroglobulinemia) were examined for the presence of anti-histone activity. Thirty-four sera were found positive. In 12 of these cases the serum monoclonal immunoglobulins were purified and in all, the anti-histone activity appeared to reside in the monoclonal component. None of the patients had symptomatology of lupus despite high titers of anti-histone activity. This study demonstrates an anti-histone activity of monoclonal components of patients with monoclonal gammopathies.
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis; D000911:Antibodies, Monoclonal / Q000032:analysis* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology; D003449:Cryoglobulinemia / Q000097:blood / Q000276:immunology*; D004247:DNA / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006657:Histones / Q000276:immunology*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000097:blood / Q000276:immunology*; D009101:Multiple Myeloma / Q000097:blood / Q000276:immunology*; D010266:Paraproteins / Q000032:analysis* / Q000276:immunology; D008258:Waldenstrom Macroglobulinemia / Q000097:blood / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D006657:Histones; D010266:Paraproteins; D004247:DNA