Serological and biochemical genetic markers in congenital cleft lip and cleft palate anomalies.
Serological and biochemical genetic markers in 76 patients with cleft lip with or without cleft palate [CL(P)] and 24 patients with isolated cleft palate (CP) were studied and compared with healthy control subjects. Blood group A phenotype and homozygous plasma haptoglobin (2-2) were found associated with CL(P). The findings suggest that the individuals possessing these markers are more likely to develop congenital CL(P).
D000017:ABO Blood-Group System; D002971:Cleft Lip / Q000097:blood / Q000235:genetics*; D002972:Cleft Palate / Q000097:blood / Q000235:genetics*; D005819:Genetic Markers; D005838:Genotype; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D010641:Phenotype; D012204:Rh-Hr Blood-Group System
D000017:ABO Blood-Group System; D005819:Genetic Markers; D006242:Haptoglobins; D012204:Rh-Hr Blood-Group System