A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimer's disease.
Various cytoskeletal proteins have been implicated in the formation of neurofibrillary tangles in Alzheimer's disease. A monoclonal antibody to non-phosphorylated neurofilament protein labels a distinct subset of pyramidal cells in the normal human cortex which have a distribution very similar to that of neurofibrillary tangles in brains from patients with Alzheimer's disease. In addition, regions and layers that normally contain a high density of such cells, in Alzheimer's disease, have large numbers of neurofibrillary tangles and few remaining immunoreactive cells.
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000911:Antibodies, Monoclonal; D002540:Cerebral Cortex / Q000032:analysis* / Q000473:pathology; D006624:Hippocampus / Q000032:analysis / Q000473:pathology; D006801:Humans; D007381:Intermediate Filament Proteins / Q000032:analysis* / Q000276:immunology; D008875:Middle Aged; D009454:Neurofibrils / Q000032:analysis / Q000473:pathology; D016900:Neurofilament Proteins
D000911:Antibodies, Monoclonal; D007381:Intermediate Filament Proteins; D016900:Neurofilament Proteins