Serine-O-phosphate, an endogenous metabolite, inhibits the stimulation of inositol phospholipid hydrolysis elicited by ibotenic acid in rat hippocampal slices.
Serine-O-phosphate (PS) inhibits the accumulation of 3H-inositolmonophosphate elicited by ibotenic acid in rat hippocampal slices incubated in the presence of 7 mM Li+. This inhibition is concentration- dependent and stereoselective, L-PS being 5 fold more potent than D-PS. Among different structural analogues of PS, only L-serine weakly antagonizes the action of ibotenic acid, whereas phosphorylcholine, phosphorylethanolamine and phosphothreonine are inactive even at high concentrations. These results are consistent with the hypothesis that L-PS may act as an endogenous regulator of excitatory amino acid receptor function.
D000818:Animals; D003864:Depression, Chemical; D006624:Hippocampus / Q000378:metabolism*; D006868:Hydrolysis; D007051:Ibotenic Acid / Q000494:pharmacology*; D066298:In Vitro Techniques; D007295:Inositol Phosphates / Q000378:metabolism*; D008566:Membranes / Q000378:metabolism; D010080:Oxazoles / Q000494:pharmacology*; D010768:Phosphoserine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012694:Serine / Q000031:analogs & derivatives*; D013403:Sugar Phosphates / Q000378:metabolism*
D007295:Inositol Phosphates; D010080:Oxazoles; D013403:Sugar Phosphates; D010768:Phosphoserine; D007051:Ibotenic Acid; D012694:Serine