Hypercalcemia and reversible renal failure in heavy-chain disease.
We have reported a case of gamma heavy-chain disease associated with hypercalcemia and reversible renal failure. After combined chemotherapy the patient remains well after 21 months of follow-up, and serum calcium levels remain in the normal range. This case supports the notion of Kyle et al that heavy-chain disease may present a diverse picture, and documents the first use of aggressive combination chemotherapy in the management of associated moderately severe hypercalcemia and hypercalcemic renal failure.
D058186:Acute Kidney Injury / Q000209:etiology*; D000368:Aged; D002118:Calcium / Q000097:blood; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D006362:Heavy Chain Disease / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy / Q000209:etiology*; D007142:Immunoglobulin gamma-Chains / Q000032:analysis; D007674:Kidney Diseases / Q000188:drug therapy; D008297:Male; D008545:Melanoma / Q000175:diagnosis; D011241:Prednisone / Q000008:administration & dosage; D013997:Time Factors; D014750:Vincristine / Q000008:administration & dosage
D007142:Immunoglobulin gamma-Chains; D014750:Vincristine; D003520:Cyclophosphamide; D002118:Calcium; D011241:Prednisone