title: Local disodium cromoglycate is ineffective in ulcerative proctosigmoiditis.
abstract: Conflicting results have emerged from studies using oral and rectal disodium cromoglycate (DSCG) in inflammatory bowel disease. In the present double-blind study, 43 patients with active ulcerative proctosigmoiditis received either placebo (n = 22) or 600 mg DSCG (n = 21) rectally as enemas for eight weeks. Assessment was made from clinical investigations, endoscopy, laboratory tests, biopsies, and diary cards. No statistically significant differences in bowel frequency, rectal bleeding, general well-being, abdominal pain, and severity and extent of the disease were found between the groups during the study. There was no significant change in the histologic parameters. No side-effect was encountered. It is concluded that DSCG did not improve symptoms or inflammatory changes in ulcerative proctosigmoiditis.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003092:Colitis / Q000188:drug therapy*; D004205:Cromolyn Sodium / Q000008:administration & dosage*; D004311:Double-Blind Method; D004733:Enema; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011350:Proctocolitis / Q000188:drug therapy*; D012007:Rectum; D013607:Tablets
chemical_list: D013607:Tablets; D004205:Cromolyn Sodium