Enhanced toxicity of copper for Streptococcus mutans under anaerobic conditions.
Copper inhibition of 11 strains (serotypes a through g) of Streptococcus mutans was increased by anaerobic incubation. Anaerobic toxicity was reversed by cuprous, but not by cupric, chelators. Susceptibility to aerobic copper inhibition was related to serotype; serotypes c, e, and f (biotype I) were most sensitive.
D000693:Anaerobiosis; D003300:Copper / Q000378:metabolism / Q000494:pharmacology*; D003676:Deferoxamine / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D005297:Ferrozine / Q000494:pharmacology; D010618:Phenanthrolines / Q000494:pharmacology; D012703:Serotyping; D013295:Streptococcus mutans / Q000145:classification / Q000187:drug effects*
D010618:Phenanthrolines; D005297:Ferrozine; C028559:bathocuproine sulfonate; D003300:Copper; D004492:Edetic Acid; D003676:Deferoxamine