Gastric mucosal binding studies with enprostil: a potent anti-ulcer prostaglandin.
The potent antiulcer prostaglandin enprostil binds with high affinity to porcine gastric mucosal tissues. This binding is saturable, dissociable and displaceable by compounds with similar structures. Various characteristics of binding such as pH optimum and displacement potencies suggest that enprostil binds to mucosal PGE2 sites. Structure-activity and gastric mucosal binding relationships were also examined.
D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D002462:Cell Membrane / Q000378:metabolism; D015232:Dinoprostone; D016620:Enprostil; D005744:Gastric Acid / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D010437:Peptic Ulcer / Q000517:prevention & control; D011458:Prostaglandins E / Q000378:metabolism; D011459:Prostaglandins E, Synthetic / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D013552:Swine
D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; D016620:Enprostil; D015232:Dinoprostone