title: Inhibition of de novo purine synthesis by methylthioadenosine.
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D002460:Cell Line; D003839:Deoxyadenosines; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology / Q000378:metabolism*; D010430:Pentosyltransferases / Q000378:metabolism*; D011683:Purine-Nucleoside Phosphorylase / Q000172:deficiency / Q000378:metabolism*; D011687:Purines / Q000096:biosynthesis*; D013872:Thionucleosides / Q000378:metabolism / Q000633:toxicity*
chemical_list: D003839:Deoxyadenosines; D011687:Purines; D013872:Thionucleosides; C008500:5'-methylthioadenosine; D010430:Pentosyltransferases; D011683:Purine-Nucleoside Phosphorylase; C021784:5'-methylthioadenosine phosphorylase; D000241:Adenosine