title: Technique for assessing the response of the respiratory controller to hypoxia and hypercapnia.
abstract: A technique, suitable for clinical practice, has been developed to measure quantitatively and separately the effects of hypercapnia on the central and peripheral chemoreceptors, and hypoxia on the peripheral chemoreceptors of a human subject. The technique uses a model to account for the dynamics of CO2 transport in the brain and is based on current concepts of the chemoreceptor system and makes a minimum of assumptions. The method was tested in one subject and there was evidence for hysteresis in the response to hypoxia and short-term adaptation in the response to hypercapnia of the chemoreceptor controller.
mesh_terms: D001698:Biomedical Engineering; D001921:Brain / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism; D002628:Chemoreceptor Cells / Q000378:metabolism; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism; D012119:Respiration; D012143:Respiratory Physiological Phenomena
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen