title: Absence of HLA linkage in familial hypogonadotropic hypogonadism.
abstract: In a family with five daughters, three suffered from primary amenorrhea. The diagnosis of familial idiopathic gonadotropin deficiency (FIGD) was established. The entire family underwent HLA evaluation, and no linkage between the HLA and FIGD was found.
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000172:deficiency*; D005808:Genes, Recessive; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006681:HLA-D Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007006:Hypogonadism / Q000235:genetics*; D007986:Luteinizing Hormone / Q000172:deficiency*; D010375:Pedigree; D013577:Syndrome
chemical_list: D006680:HLA Antigens; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone