Further evidence that noradrenaline is not involved in the anti-immobility activity of chronic desipramine in the rat.
The effect of 10 mg/kg per day desipramine for 7 days on performance in the forced swimming test was studied in rats given various treatments aimed at reducing central noradrenergic transmission. 6-Hydroxydopamine-induced destruction of noradrenaline-containing neurons originating in the locus coeruleus or ascending in the ventral bundle had no effect on the anti-immobility activity of desipramine. Likewise, no changes in the effect of desipramine were seen with an intraperitoneal injection of DSP-4 (50 mg/kg) which destroyed brain noradrenergic neurons, particularly those of the dorsal bundle ascending to the forebrain. The results argue against a role of noradrenaline in the mechanism by which repeated treatment with desipramine reduces the immobility of rats in the forced swimming test.
D000818:Animals; D001596:Benzylamines / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects*; D003891:Desipramine / Q000494:pharmacology*; D006892:Hydroxydopamines / Q000008:administration & dosage; D007103:Immobilization; D007267:Injections; D008125:Locus Coeruleus; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology*; D016627:Oxidopamine; D051381:Rats; D013563:Sympathectomy, Chemical
D001596:Benzylamines; D006892:Hydroxydopamines; D016627:Oxidopamine; C012102:DSP 4; D003891:Desipramine; D009638:Norepinephrine