Unusual thoracic manifestations of epithelioid hemangioendothelioma.
Intravascular bronchioloalveolar tumors are now recognized as the pulmonary analogue of epithelioid hemangioendotheliomas of the somatic soft tissues. These low-grade endothelial sarcomas have a typical histologic appearance and usually present as bilateral pulmonary nodules in young women. The present report describes four unusual clinical manifestations of the epithelioid hemangioendothelioma: as an anterior mediastinal mass, as diffuse pleural thickening resembling malignant mesothelioma, as a metastatic carcinoma with cancerization of the lymphatics (lymphagitic carcinoma), and as a solitary peripheral calcified nodule. These anomalous clinical presentations correspond to unusual histologic appearances of the tumor at open-lung biopsy, and need to be recognized by both the clinician and the pathologist.
D000328:Adult; D000368:Aged; D000941:Antigens / Q000032:analysis; D002114:Calcinosis / Q000473:pathology; D003937:Diagnosis, Differential; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D005260:Female; D006390:Hemangioendothelioma / Q000032:analysis / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000032:analysis / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology; D008654:Mesothelioma / Q000473:pathology; D008875:Middle Aged; D014841:von Willebrand Factor
D000941:Antigens; D014841:von Willebrand Factor; D005169:Factor VIII