[The lack of ability of carcinogens and non-carcinogenic analogs to induce sex-linked recessive lethals in Drosophila melanogaster].
The mutagenic activity of two known carcinogens (benzo(a) pyrene and 2-acetylaminofluorene) and that of two structurally closely related but not carcinogenic compounds (pyrene and 4-acetylaminofluorene) was examined by the Muller-5 test for sex-linked recessive lethals (SRL). The chemicals tested were applied to the food medium for larvae of Canton-S Drosophila melanogaster. No statistically significant differences in frequencies of induced SRL were found either within pairs of chemicals or between treated and untreated animals.
D015073:2-Acetylaminofluorene / Q000633:toxicity / Q000031:analogs & derivatives; D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity; D002273:Carcinogens; D004331:Drosophila melanogaster / Q000235:genetics*; D005804:Genes, Lethal; D005808:Genes, Recessive; D008040:Genetic Linkage; D009152:Mutagenicity Tests; D011721:Pyrenes / Q000633:toxicity; D013329:Structure-Activity Relationship; D014960:X Chromosome
D002273:Carcinogens; D011721:Pyrenes; D001564:Benzo(a)pyrene; C030984:pyrene; D015073:2-Acetylaminofluorene; C028676:4-acetylaminofluorene
Otsutstvie sposobnosti kantserogenov i nekartsenogennykh analogov vyzyvat' stseplennye s polom retsessivnye letali u Drosophila melanogaster.