The T-lymphocyte population in first-trimester human decidua does not express the interleukin-2 receptor.
The expression of the IL-2 receptor by T lymphocytes in human uterine decidua has been studied with two monoclonal antibodies to the IL-2 receptor employed in immunoperoxidase labelling of serial cryostat sections. Infiltrating T lymphocytes in early pregnancy decidua do not express the IL-2 receptor. Endometrial gland epithelium in early pregnancy showed unexpected reactivity with one of the mAbs to the IL-2 receptor (Tac). Thus, despite the close proximity of fetal trophoblast, macrophages and T-lineage lymphocytes in decidua in early pregnancy, IL-2 receptor-bearing lymphocytes are completely absent.
D003656:Decidua / Q000276:immunology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007376:Interleukin-2; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011948:Receptors, Antigen, T-Cell / Q000032:analysis*; D011971:Receptors, Immunologic / Q000032:analysis*; D015375:Receptors, Interleukin-2; D013601:T-Lymphocytes / Q000276:immunology*
D007376:Interleukin-2; D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2