Inhibition of ADP-ribosylation of histone H1 by analogs of diadenosine 5',5'''-p1,p4-tetraphosphate.
The effects of analogs of diadenosine 5',5'''-p1,p4-tetraphosphate (Ap4A) were examined on the ADP-ribosylation reaction of histone H1 catalysed by purified bovine thymus poly(ADP-ribose)transferase. Among the compounds tested, epsilon Ap4A and ApCH2pppA were shown to be the most efficient inhibitors of the enzyme. From kinetic studies of their action, it appears that epsilon Ap4A and ApCH2pppA might be 'mixed type' inhibitors.
D000227:Adenine Nucleotides / Q000494:pharmacology*; D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D015226:Dinucleoside Phosphates; D006657:Histones / Q000378:metabolism*; D007700:Kinetics; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D013329:Structure-Activity Relationship; D013950:Thymus Gland / Q000201:enzymology
D000227:Adenine Nucleotides; D015226:Dinucleoside Phosphates; D006657:Histones; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D000246:Adenosine Diphosphate Ribose; C020733:diadenosine tetraphosphate