[Kinetic model of a multienzyme system of blood prostanoid synthesis. II. Dynamic responses to pharmacological agents--inhibitors of prostaglandin H synthetases].
The dynamic replies of the multienzyme system of blood prostanoid synthesis to the introduction of an irreversible inhibitor of prostaglandin H synthetase (PGH synthetase) have been analysed by using kinetic modelling. The alterations of arachidonic acid and PGH synthetase concentrations in platelets and endothelium and the concentrations of thromboxane and prostacyclin have been demonstrated. Particularities of kinetic behaviour of the system probably providing the therapeutic effect of non-steroidal anti-inflammatory drugs have been shown. Namely, the kinetic wave of free arachidonic acid and prostacyclin concentration with respect to thromboxane concentration appears after introduction of the drugs.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood; D001792:Blood Platelets / Q000201:enzymology; D016861:Cyclooxygenase Inhibitors; D004727:Endothelium / Q000201:enzymology; D011464:Epoprostenol / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000097:blood*; D013928:Thromboxane A2 / Q000096:biosynthesis* / Q000097:blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D009097:Multienzyme Complexes; D016718:Arachidonic Acid; D013928:Thromboxane A2; D011464:Epoprostenol
Kineticheskaia model' polifermentnoĭ sistemy sinteza prostanoidov krovi. II. Dinamicheskie otvety pri vvedenii farmakologicheskikh preparatov--ingibitorov prostaglandin H-sintetaz.