[Role of vasodilator agents in the complex treatment of circulatory insufficiency in patients with ischemic heart disease].
The paper is concerned with the results of therapy of CHD patients with circulatory insufficiency using cardiac glycosides combined with a nitrate of prolonged action (sustak) and an arterial dilator apressin. Since the patients were advanced in years, sustak was given at average doses of 6.4 mg every 8 h and apressin at a daily dose of 75 mg. Additional treatment with vasodilators resulted in positive hemodynamic shifts in the patients with stage IIA and IIB circulatory insufficiency. The highest hemodynamic effect in therapy of marked circulatory insufficiency was observed in the patients with a low initial cardiac output and a high peripheral vascular resistance after multimodality therapy (cardiac glycosides, sustak and apressin). Changes in hemodynamics should be taken into account during therapy with vasodilators and control over their efficacy should be exercised.
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy*; D003327:Coronary Disease / Q000150:complications*; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D014665:Vasodilator Agents; D006830:Hydralazine; D005996:Nitroglycerin
Rol' vazodilatatorov v kompleksnoĭ terapii nedostatochnosti krovoobrashcheniia u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.