title: [Role of the time factor in the pancreatic and extrapancreatic mechanisms of action of glibenclamide].
abstract: A study was made of the effect of short- and long-term administration of one of the sulfanilurea derivatives of the 2nd generation--glibenclamide on pancreatic beta-cell function and the sensitivity of peripheral tissues to insulin under clinical and experimental conditions. The authors established time correlation of the mechanisms of glibenclamide hypoglycemic action: beta-cytotropic action in acute administration of the drug and extrapancreatic influence in chronic administration. An idea of predominant significance of the postreceptor level in the realization of the extrapancreatic effect of long-term administration of glibenclamide was substantiated.
mesh_terms: D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002096:C-Peptide / Q000097:blood; D002682:Chinchilla; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D005905:Glyburide / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D005905:Glyburide
vernacular_title: Znachenie vremennogo faktora v realizatsii pankreaticheskogo i vnepankreaticheskogo mekhanizmov deĭstviia glibenklamida.