Influence of complex charge and size on the uptake of 99mTc-diphosphonates in osteogenic tissue.
The biodistributions of six chromatographically pure 99mTc-HEDP complexes have been determined in soft tissues, normal bone and osteogenic lesions (induced with a Walker 256 tumor) in Fisher 344 rats. The physical properties of each 99mTc-HEDP complex including anionic charge, partial molar volume, molecular weight and spectral characteristics are known; thus allowing structure-activity relationships to be drawn. The results indicate that the smallest, low charged, mononuclear 99mTc-HEDP complexes have the greatest uptake in bone lesions, and the highest lesion to muscle and lesion to normal bone ratios.
D000818:Animals; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism*; D002279:Carcinoma 256, Walker / Q000000981:diagnostic imaging / Q000378:metabolism*; D012968:Etidronic Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D008297:Male; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D051381:Rats; D011916:Rats, Inbred F344; D012016:Reference Values; D013270:Stomach / Q000000981:diagnostic imaging; D013667:Technetium / Q000378:metabolism*; D014018:Tissue Distribution
D015609:Organotechnetium Compounds; C019561:technetium Tc 99m etidronate; D013667:Technetium; D012968:Etidronic Acid