Coronary vasoactivity of four 7,13-bridged analogs of arachidonic acid.
Four newly synthesized 7,13-bridged arachidonic acid analogs which have been shown to exert 5-lipoxygenase inhibitory activity were studied in isolated perfused cat coronary arteries. The two dehydro analogs constricted and the two non-dehydro analogs dilated the coronary arteries. None antagonized LTD4 induced constriction. Thus there is no direct connection between lipoxygenase inhibition and leukotriene inhibition or vasoactivity.
D000818:Animals; D001091:Arachidonate Lipoxygenases; D001095:Arachidonic Acids / Q000494:pharmacology*; D002415:Cats; D003331:Coronary Vessels / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D016859:Lipoxygenase Inhibitors; D008297:Male; D010477:Perfusion; D013189:SRS-A / Q000037:antagonists & inhibitors; D014661:Vasoconstriction / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects
D001095:Arachidonic Acids; D016859:Lipoxygenase Inhibitors; D013189:SRS-A; D001091:Arachidonate Lipoxygenases