title: A membrane-specific tyrosinase chelate: the mitotic regulator?
abstract: Cancer's random, reversible, unstable transitions to "normal" structures imply their functional relation. Similar random, continuous, reversible oncogene "mutational transformation" also lacks a consistent hybrid. Positing cancer's "mutationally altered genotype" leads to medically foreign causes, qualities, inducers, suppressors, immune proteins, and viruses. Its random variation, however, opposes the functionally discrete, ordered, stable, irreversible hybrid variation and single-valued transforms of molecular genetics. There, "causal mutational operators" remain unspecified; only consistent single-valued DNA base and amino acid change, as "transform operand", are made explicit. A mitotically "blocked" (normal) and "unblocked" (malignant) stem cell "phenotype", operationally constructed from microscopic data, is therefore viewed within the homeostatic context of open-system enzyme-regulatory equilibrium. This functional, stochastic field distribution between "structurally bound" and "freely dividing" stem cell number discloses their putative regulatory mitotic-blocking factor. A tyrosinase complex, interacting by Cu2+-Fe2+ chelation with a proline hydroxylase divisional enzyme near stem cell ribosomes, maintains steady-state mitotic equilibrium. Based upon familiar medical, biochemical, and energy principles this confronts cancer's pigmentary-depigmentary signs, glycolytic metabolism, elevated serum tyrosinase, defective collagen production, exposed membrane binding sites, and tyrosine's recent growth control role.
mesh_terms: D004156:Catechol Oxidase / Q000502:physiology*; D002614:Chelating Agents / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008566:Membranes / Q000201:enzymology; D008938:Mitosis; D008954:Models, Biological; D014442:Monophenol Monooxygenase / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D009369:Neoplasms / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D009857:Oncogenes
chemical_list: D002614:Chelating Agents; D004156:Catechol Oxidase; D014442:Monophenol Monooxygenase