A retinal heat shock protein is associated with elements of the cytoskeleton and binds to calmodulin.
Elevation of body temperature to a level similar to that attained during fever induces a disaggregation of polysomes in the mammalian retina and induction of a 74K heat shock protein (hsp74). Induced retinal hsp74 copurifies with twice cycled microtubules and also with purified intermediate filaments, is precipitated by antibodies prepared against purified Tau proteins and binds to calmodulin.
D000818:Animals; D000906:Antibodies / Q000276:immunology; D002147:Calmodulin / Q000378:metabolism*; D003429:Cross Reactions; D003599:Cytoskeleton / Q000032:analysis*; D005470:Fluorometry; D006360:Heat-Shock Proteins / Q000276:immunology / Q000378:metabolism*; D007382:Intermediate Filaments / Q000032:analysis; D008297:Male; D008869:Microtubule-Associated Proteins / Q000276:immunology; D008870:Microtubules / Q000032:analysis; D011817:Rabbits; D012160:Retina / Q000648:ultrastructure*; D016875:tau Proteins
D000906:Antibodies; D002147:Calmodulin; D006360:Heat-Shock Proteins; D008869:Microtubule-Associated Proteins; D016875:tau Proteins