Role of calcium in prolactin analgesia.
The effect of calcium chloride and nifedipine on prolactin-(PRL) induced analgesia was studied by chemical assay and compared with other analgesics like morphine, thyrotrophin-releasing hormone (TRH) and clonidine. Nifedipine potentiated the analgesic effect of PRL similar to morphine while that of clonidine and TRH remained unaltered. Further, calcium chloride administration antagonized the analgesic effect of PRL and of morphine. These data suggest that PRL, similar to morphine, may alter calcium movements across the membrane to produce analgesia.
D000700:Analgesics; D000818:Animals; D002118:Calcium / Q000502:physiology*; D002122:Calcium Chloride / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology; D011388:Prolactin / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D000700:Analgesics; D013973:Thyrotropin-Releasing Hormone; D009020:Morphine; D011388:Prolactin; D009543:Nifedipine; D002122:Calcium Chloride; D003000:Clonidine; D002118:Calcium