title: In vitro activity of ofloxacin against 210 clinical isolates of typhoid salmonellae.
abstract: 210 clinical isolates of typhoid salmonellae, cultivated from blood of patients with typhoid fever (108 strains of Salmonella typhi, 99 strains of Salmonella paratyphi A and three strains of Salmonella paratyphi B) as well as 266 random clinical isolates of Escherichia coli (n = 152), Klebsiella spp. (n = 51) and Proteus spp. (n = 63) were tested for susceptibility to ofloxacin, using an agar dilution method. All the typhoid salmonellae were found to be highly sensitive to ofloxacin with MICs ranging from 0.03 mg/l to 0.12 mg/l. The sensitivity pattern of enterobacteriaceae was comparable to data published internationally.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology*; D010284:Paratyphoid Fever / Q000382:microbiology; D012475:Salmonella / Q000187:drug effects*; D012482:Salmonella paratyphi A / Q000187:drug effects* / Q000302:isolation & purification; D012484:Salmonella paratyphi B / Q000187:drug effects* / Q000302:isolation & purification; D012485:Salmonella typhi / Q000187:drug effects* / Q000302:isolation & purification; D014435:Typhoid Fever / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D010078:Oxazines; D015242:Ofloxacin