[Changes in the number of sister chromatid exchanges in cultured Chinese hamster cells with limited proliferation. Additional studies].
During "stationary phase ageing" of cultured Chinese hamster cells (B11dii-FAF28 line, 2372a clone), i. e. while decreasing the proliferation rate and in the stationary growth phase the frequency of spontaneous sister chromatid exchanges (SCE) progressively increases (from 2- to 23-day "age"); the frequency of thiophosphamide-induced (1h) SCE increases from 2- to 23-day "age" by the same value as the frequency of spontaneous SCE; the cells deepen into the R-phase of the cell cycle.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013852:Thiotepa / Q000494:pharmacology
D013852:Thiotepa
Izmeneniia urovnia sestrinskikh khromatidnykh obmenov v kul'tiviruemykh kletkakh kitaĭskogo khomiachka pri ogranichenii ikh proliferatsii. Dopolnitel'nye issledovaniia.