Some cardiotonics enhance the effectiveness of angiotensin II-induced hypertension cancer chemotherapy in mice.
Angiotensin II-induced hypertension chemotherapy proved to be more effective than conventional chemotherapy using cis-diamminedichloroplatinum (II) (DDP), when applied to an established mouse mammary carcinoma. In an attempt to improve the effectiveness, a cardiotonic such as aminophylline or trans-pi-oxocamphor was added to a solution containing angiotensin II and DDP. A remarkable improvement in therapeutic efficacy was apparent as compared to angiotensin II hypertension chemotherapy. A possible synergism between angiotensin II and the cardiotonic may result in selective delivery of the antitumor drug to the tumor tissue.
D000628:Aminophylline / Q000627:therapeutic use; D000804:Angiotensin II / Q000627:therapeutic use*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use; D004357:Drug Synergism; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000188:drug therapy*
D002316:Cardiotonic Agents; D000804:Angiotensin II; D000628:Aminophylline; D002945:Cisplatin