Bioconcentration potential of organic environmental chemicals in humans.
A list of environmental chemicals detectable in adipose tissue and/or milk of non-occupationally exposed humans is presented. Besides their physiochemical properties (n-octanol/water partition coefficient and water solubility), their acceptable daily intake (ADI) values, production figures, fate in the environment, concentrations in human adipose tissue, and data from total diet studies from market basket investigations are given. Average bioconcentration factors (BCF) of polychlorinated biphenyls (PCBs), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), DDT, hexachlorobenzene (HCB), dieldrin, hexachlorocyclohexane isomers (alpha-HCH, beta-HCH, gamma-HCH, delta-HCH), pentachlorophenol (PCP), and 3,5-di-tert-butyl-4-hydroxytoluene (BHT) in human adipose tissue are calculated. The bioconcentration factors (wet wt basis) of these compounds are between 3 and 47 times higher in humans than in rats. The environmental chemicals are divided into three groups in respect to their bioconcentration factors in human adipose tissue: group I, high BCF (greater than 100); group II, medium BCF (10-100); and group III, low BCF (less than 10). The bioconcentration factors are useful for hazard assessment of chemicals to humans.
D000273:Adipose Tissue / Q000378:metabolism; D000393:Air Pollutants / Q000378:metabolism*; D002084:Butylated Hydroxytoluene / Q000378:metabolism; D003634:DDT / Q000378:metabolism; D004026:Dieldrin / Q000378:metabolism; D004032:Diet; D006581:Hexachlorobenzene / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008433:Mathematics; D008954:Models, Biological; D010416:Pentachlorophenol / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000378:metabolism; D000072317:Polychlorinated Dibenzodioxins / Q000378:metabolism; D014018:Tissue Distribution; D014873:Water Pollutants / Q000378:metabolism*
D000393:Air Pollutants; D000072317:Polychlorinated Dibenzodioxins; D014873:Water Pollutants; D002084:Butylated Hydroxytoluene; D006581:Hexachlorobenzene; D003634:DDT; D010416:Pentachlorophenol; D011078:Polychlorinated Biphenyls; D004026:Dieldrin