[Immunoregulative effects of homocarnosine and gamma-aminobuthyric acid].
The effects of homocarnosine and GABA on antibody production (PFC reaction) and cellular immunity (delayed hypersensitivity reaction, DHR) were examined in vivo. In mice treated with these agents, PFC reaction to 2 X 10(7) SRBC was enhanced but that to 1 X 10(9) SRBC was suppressed; moreover, immunoreaction was reduced in immature mice (2-2.5 weeks old) but was increased in aged mice (30 weeks old or above). These agents had optimal doses on the PFC reaction in mice given 1 X 10(8) SRBC and DHR, and induced recovery of immunofunction suppressed by the administration of MMC.
D000375:Aging / Q000276:immunology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002336:Carnosine / Q000031:analogs & derivatives / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology; D006706:Homeostasis / Q000187:drug effects; D007109:Immunity / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D051379:Mice; D016685:Mitomycin; D008937:Mitomycins / Q000037:antagonists & inhibitors; D014945:Wound Healing / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology / Q000502:physiology*
D004151:Dipeptides; D008937:Mitomycins; C005038:homocarnosine; D016685:Mitomycin; D005680:gamma-Aminobutyric Acid; D002336:Carnosine