title: Activity of ciprofloxacin against multiply resistant strains of Pseudomonas aeruginosa, Staphylococcus epidermidis, and group JK corynebacteria.
abstract: The susceptibilities of multiply resistant clinical isolates of Pseudomonas aeurginosa to ciprofloxacin, norfloxacin, and several beta-lactam and aminoglycoside antibiotics were evaluated. Ciprofloxacin also was compared with methicillin and vancomycin against methicillin-resistant Staphylococcus epidermidis and group JK corynebacteria. Ciprofloxacin exhibited the lowest MICs and MBCs for 90% of the isolates among all of the antibiotics tested against P. aeruginosa. In addition, ciprofloxacin exhibited excellent bactericidal activity against the gram-positive organisms. Clinical trials are necessary to confirm the in vitro results and monitor for emergence of resistance.
mesh_terms: D000192:Actinomycetales / Q000187:drug effects*; D002439:Cefotaxime / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D008712:Methicillin / Q000494:pharmacology; D008802:Mezlocillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000494:pharmacology; D010403:Penicillin Resistance; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013212:Staphylococcus epidermidis / Q000187:drug effects*; D013982:Ticarcillin / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D005839:Gentamicins; D002939:Ciprofloxacin; D014640:Vancomycin; D013982:Ticarcillin; D009643:Norfloxacin; D002439:Cefotaxime; D008802:Mezlocillin; D008712:Methicillin