An inhibitor to factor VIII:C in a patient with possible combined haemophilia A and von Willebrand's disease.
A factor VIII inhibitor has been found in a patient with an unusual combination of factor VIII-related properties. The inhibitor is directed specifically against the clotting activity (VIII:C) of the factor VIII complex. It behaves in a similar fashion to high responding inhibitors of factor VIII seen in haemophilia A patients and it was characterised as an immunoglobulin of the IgG class. Laboratory results from the patient and his family show considerable variation of factor VIII-related properties between various individuals. Overall, the data suggests the co-existence of haemophilia A and von Willebrand's disease in the family and the presence of both diseases in the patient.
D002675:Child, Preschool; D005169:Factor VIII / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000302:isolation & purification; D014644:Genetic Variation; D006467:Hemophilia A / Q000097:blood* / Q000150:complications / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008297:Male; D010375:Pedigree; D014842:von Willebrand Diseases / Q000097:blood* / Q000150:complications / Q000235:genetics / Q000473:pathology
D005169:Factor VIII