[Morphologic changes and cytochrome P-450 induction in the liver of the rat after exposure to polychlorinated biphenyls in various diets].
In is shown that administration of sovol, a mixture of polychlorinated diphenyls, in a dose of 500 mg/kg (about 1:10 LD50) induces pronounced changes in the rat liver structure, in particular, fat accumulation and diminution of RNA lump number in hepatocyte cytoplasma, alteration of nuclei, decrease in the number of hepatocytes and binuclear cells in the visual field. Structural disorders in the liver are observed during a long period (up to 5 months) and, to a certain extent, depend on the composition of the lipid component of the ration. Certain differences are recorded in the character of the morphological changes in the liver after single and repeated injections of the agent. No distinct relationship is recorded between the manifestation of hepatocyte fat infiltration and other morphological changes in the liver, and the index of microsomal cytochrome P-450 induction during sovol action.
D000818:Animals; D002079:Butter; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004041:Dietary Fats / Q000008:administration & dosage*; D004790:Enzyme Induction / Q000187:drug effects; D005234:Fatty Liver / Q000139:chemically induced* / Q000473:pathology; D006368:Helianthus; D008099:Liver / Q000201:enzymology / Q000473:pathology*; D008297:Male; D010938:Plant Oils / Q000008:administration & dosage*; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D004041:Dietary Fats; D010938:Plant Oils; D002079:Butter; D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls
Morfologicheskie izmeneniia i induktsiia tsitokhroma P-450 pecheni krys posle vozdeĭstviia polikhlorirovannymi difenilami v usloviiakh razlichnogo pitaniia.