[Delayed hypersensitivity and nonspecific cellular immunity. The cytotoxic activity of macrophages, natural and antibody-dependent killer cells].
The experiment on (BALB/cXC57BL)F1 mice, showing a high level of delayed hypersensitivity (DH) when sensitized with BCG vaccine and Staphylococcus aureus strain B-243, has demonstrated the influence of such sensitization and DH reaction induced by the injection of a specific antigen (old tuberculin or staphylococcal phagolysate) into the sensitized animals on the cytotoxicity of macrophages, natural killers (NK) and antibody-dependent killers (ADK). Sensitization with BCG vaccine alone results in an insignificant rise in the activity of these effector cells, and sensitization with S. aureus produces no changes at all. The pronounced activation of the cytotoxicity of macrophages, NK and, to a lesser extent, ADK has been observed in DH reaction induced by the injection of a specific antigen into the sensitized mice. In the course of DH reaction a rise in the activity of NK and ADK not only against tumor target cells, but also against microbial ones (Candida albicans and S. aureus) has been found to occur.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D001500:BCG Vaccine / Q000276:immunology; D002176:Candida albicans / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007111:Immunity, Cellular; D007114:Immunization; D007694:Killer Cells, Natural / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D012515:Mast-Cell Sarcoma / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013211:Staphylococcus aureus / Q000276:immunology; D013997:Time Factors; D014373:Tuberculin / Q000276:immunology
D001500:BCG Vaccine; D014373:Tuberculin
Giperchuvstvitel'nost' zamedlennogo tipa i nespetsificheskiĭ kletochnyĭ immunitet. Tsitotoksicheskaia aktivnost' makrofagov, estestvennykh i antitelozavisimykh killernykh kletok.