title: The alloantibody response in the allogeneically pregnant rat. IV. Analysis of the alloantibody specificities with monoclonal antibodies.
abstract: We have compared the serum alloantibody population from female rats immunized either by allogeneic pregnancies or by conventional immunizations. The only allogeneic difference in both types of immunization was class I of the MHC. Pregnancy-induced alloantibodies as compared with conventionally raised alloantibodies were more homogeneous with respect to isoelectric point, and were more homogeneous as defined by competition experiments with anti-class I monoclonal antibodies. The genetic control of the pregnancy-induced alloantibody response was also verified.
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000502:physiology; D000918:Antibody Specificity; D001666:Binding Sites, Antibody; D001667:Binding, Competitive; D005260:Female; D005802:Genes, MHC Class II; D006649:Histocompatibility Antigens / Q000235:genetics / Q000276:immunology; D007518:Isoantibodies / Q000032:analysis / Q000096:biosynthesis*; D007519:Isoantigens / Q000235:genetics / Q000276:immunology*; D008297:Male; D011247:Pregnancy; D051381:Rats; D011917:Rats, Inbred Lew; D013045:Species Specificity
chemical_list: D000911:Antibodies, Monoclonal; D006649:Histocompatibility Antigens; D007518:Isoantibodies; D007519:Isoantigens; C038353:histocompatibility antigens RT, rat