Multiple central venous line occlusions following an error in parenteral nutrition formulation.
Multiple occlusions of central venous catheters occurred in four patients who were receiving total parenteral nutrition (TPN). Misformulation of bulk prepared TPN solution caused temperature-dependent precipitation of calcium phosphate within the catheter during infusion.
D000368:Aged; D002130:Calcium Phosphates; D002408:Catheters, Indwelling; D011232:Chemical Precipitation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D012996:Solutions; D013696:Temperature
D002130:Calcium Phosphates; D012996:Solutions; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous