Endothelium-dependent contractions in arteries and veins.
Endothelium-dependent contractions of isolated veins can be induced with arachidonic acid and thrombin. Anoxia causes endothelium-dependent contractions in a variety of isolated arteries and veins. Rapid stretch and acetylcholine contract cerebral arteries with, but not those without endothelium. Acetylcholine (and serotonin) cause endothelium-dependent contractions in the aorta of the spontaneously hypertensive, but not that of the normotensive rat.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001158:Arteries / Q000187:drug effects / Q000502:physiology*; D004285:Dogs; D004727:Endothelium / Q000187:drug effects / Q000502:physiology; D000860:Hypoxia / Q000503:physiopathology; D010812:Physical Stimulation; D051381:Rats; D011918:Rats, Inbred SHR; D012701:Serotonin / Q000494:pharmacology; D013917:Thrombin / Q000494:pharmacology; D014661:Vasoconstriction; D014664:Vasodilation; D014680:Veins / Q000187:drug effects / Q000502:physiology*
D001095:Arachidonic Acids; D016718:Arachidonic Acid; D012701:Serotonin; D013917:Thrombin; D000109:Acetylcholine