title: Radioimmunoassay of c-myc protein.
abstract: A sensitive radioimmunoassay for human c-myc protein was developed by using an amino-terminal fragment of c-myc protein, c-myc(11-24). Immunoreactive c-myc protein was found to be present in 3 human tumors (HL-60, N231, Lu-65), which are known to have c-myc gene amplification. In contrast, c-myc protein was undetectable in 1 human tumor (H69) without c-myc gene amplification as well as in human heart tissues.
mesh_terms: D002460:Cell Line; D005784:Gene Amplification; D006801:Humans; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000032:analysis; D009842:Oligopeptides / Q000138:chemical synthesis / Q000276:immunology; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D011863:Radioimmunoassay
chemical_list: D009363:Neoplasm Proteins; D009842:Oligopeptides; D011518:Proto-Oncogene Proteins