Detoxification of the T2 fraction from a scorpion (Tityus serrulatus, Lutz and Mello) venom by iodination and some immunogenic properties of the derivatives.
The iodination of the T2 fraction abolished its lethal capacity, and doses up to 30 times the LD50 were injected i.p. in mice without noticeable toxic effects. The modified fraction retained its immunological properties. Antibodies generated against the iodinated T2 fraction were also reactive toward the native T2 fraction, T1 fraction and the whole soluble venom.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003378:Counterimmunoelectrophoresis; D005260:Female; D007114:Immunization; D005779:Immunodiffusion; D007455:Iodine; D008297:Male; D051379:Mice; D011817:Rabbits; D012604:Scorpion Venoms / Q000276:immunology; D013329:Structure-Activity Relationship
D012604:Scorpion Venoms; D007455:Iodine