Effect of generalized spike-and-wave discharge on glucose metabolism measured by positron emission tomography.
Positron emission tomography was used to study the cerebral metabolic rate for glucose (CMRGlc) in 7 adult patients with generalized spike-and-wave activity in the electroencephalogram. No consistent changes were seen in the CMRGlc. There was a slight trend toward an increased CMRGlc in 2 patients with primary generalized epilepsy, while in the 5 other patients with minor deviations from this condition or with secondary generalized epilepsy, the CMRGlc was unaffected by spike-and-wave activity or was below the normal range. Neither the amount of spike-and-wave activity in the EEG nor the presence of clinically evident absence seizures appeared to influence the CMRGlc. Therefore, we conclude that neuronal activity underlying spike-and-wave discharge does not seem to require increased glucose utilization.
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism*; D003847:Deoxyglucose / Q000031:analogs & derivatives; D004734:Energy Metabolism / Q000187:drug effects; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging* / Q000188:drug therapy; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D009474:Neurons / Q000378:metabolism; D014055:Tomography, Emission-Computed
D000927:Anticonvulsants; D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose