Effects of human pancreatic growth hormone-releasing hormone and fragments of rat hypothalamic growth hormone-releasing hormone on the activity of rat brain neurons.
The effect of human pancreatic growth hormone-releasing factor (hpGRF), rat hypothalamic GRF1-29 (rhGRF1-29) and rhGRF3-40 on spontaneous extracellular activity was studied in urethane anesthetized, male rats. The results show that these peptides similarly depress the firing rate of responsive neurons in the amygdala, caudate-putamen and globus pallidus. A single neuron was excited by hpGRF and it was localized to the medial amygdala. These findings are in line with the hypothesis that GRF has effects on the central nervous system in addition to regulating pituitary growth hormone secretion.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D013007:Growth Hormone-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D007028:Hypothalamic Hormones / Q000008:administration & dosage* / Q000145:classification; D007478:Iontophoresis; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010187:Pancreatic Hormones / Q000008:administration & dosage* / Q000145:classification; D051381:Rats; D011919:Rats, Inbred Strains; D013238:Stereotaxic Techniques
D007028:Hypothalamic Hormones; D010187:Pancreatic Hormones; D013007:Growth Hormone-Releasing Hormone