Effect of hypoglycaemia, TRH and levodopa on plasma growth hormone, prolactin, thyrotropin and cortisol in Parkinson's disease before and during therapy.
Thirteen drug-free and not severely affected patients with idiopathic Parkinson's disease underwent an insulin-hypoglycaemia test, a TRH test and a levodopa test. The responses of growth hormone, prolactin, cortisol and thyrotropin were measured, and retested under stable therapy with levodopa and benserazide. Mean basal and stimulated hormonal concentrations were in the normal range before and during therapy. Minor abnormalities were observed in individual cases, but did not indicate a hypothalamic dopamine deficit.
D000328:Adult; D000368:Aged; D001545:Benserazide / Q000627:therapeutic use; D004298:Dopamine / Q000502:physiology*; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007328:Insulin; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D011388:Prolactin / Q000378:metabolism; D013972:Thyrotropin / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone
D004338:Drug Combinations; D007328:Insulin; C005177:benserazide, levodopa drug combination; D007980:Levodopa; D013973:Thyrotropin-Releasing Hormone; D001545:Benserazide; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D004298:Dopamine