[Thrombocytosis and reduced levels of factor VIII in rheumatoid purpura in children].
Thirty three patients with Henoch-Schoenlein purpura were studied at various developmental stages of this disease: specially platelet counts and factors XIII and VIII. During the development phases: 40,6% of the patients have a slight but regressive thrombocytosis (greater than 400 G/l); and 75% a reduced factor XIII, well correlated with the severity of the clinical status (level as low as 60% can be considered as a "gravity threshold"), and corrected during the improvement of the disease. This reduced factor XIII is probably linked to the local inflammation in the vessels. Factor VIII studies (specially VIII A: Ag) were normal.
D000293:Adolescent; D001780:Blood Coagulation Tests; D002648:Child; D002675:Child, Preschool; D005169:Factor VIII / Q000032:analysis*; D006487:Hemostasis; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood* / Q000503:physiopathology; D010976:Platelet Count; D013922:Thrombocytosis / Q000097:blood*
D005169:Factor VIII
L'hyperplaquettose et la baisse du facteur XIII dans le purpura rhumatoïde de l'enfant.