Detection of antibody to LAV/HTLV-III in sera from hemophiliacs in China.
Using ELISA, Western blots and immunofluorescence techniques, we identified seropositivity for lymphadenopathy-associated virus/human lymphotropic virus-III (LAV/HTLV-III) in 4 of 18 hemophiliacs and 1 AIDS patient. The four seropositive patients had received factor VIII prepared by Armour Company. The hemophiliacs are all asymptomatic. Given this documentation of introduction of LAV/HTLV-III into China, a national surveillance program is underway.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000453:epidemiology*; D000914:Antibodies, Viral / Q000032:analysis*; D002681:China; D004797:Enzyme-Linked Immunosorbent Assay; D005169:Factor VIII / Q000627:therapeutic use; D005455:Fluorescent Antibody Technique; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies; D006467:Hemophilia A / Q000097:blood / Q000150:complications* / Q000628:therapy; D006801:Humans; D008297:Male
D000914:Antibodies, Viral; D015483:HIV Antibodies; D005169:Factor VIII