The effect of cellular calcium on Na+/K+ cotransport in human red blood cells.
The increase in Ca2+ permeability by addition of ionophore A23187 in the presence of external Ca2+ did not alter the bumetanide-sensitive Na+/K+ effluxes in human red blood cells. An inhibition of this pathway by cellular Ca2+ could be observed only under conditions in which the cellular ATP content was drastically depleted.
D002034:Bumetanide / Q000494:pharmacology; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000097:blood*; D002463:Cell Membrane Permeability / Q000187:drug effects; D004533:Egtazic Acid / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*
D002034:Bumetanide; D000001:Calcimycin; D004533:Egtazic Acid; D012964:Sodium; D011188:Potassium; D002118:Calcium