Distribution of immunoglobulin heavy chains in diseased synovia.
Synovium from 142 patients with 12 different arthropathies was examined for the distribution of alpha, delta, gamma, and mu immunoglobulin heavy chains. A high proportion of plasma cells in the superficial subintima in all diseases reacted for alpha heavy chains. Only in rheumatoid disease did the synovium contain more than 10% of plasma cells reacting for mu heavy chains.
D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002452:Cell Count; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000032:analysis*; D007137:Immunoglobulin alpha-Chains / Q000032:analysis; D007592:Joint Diseases / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D010950:Plasma Cells / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
D007143:Immunoglobulin Heavy Chains; D007137:Immunoglobulin alpha-Chains