T-2 toxin-enhanced resistance against listeriosis in mice: importance of gastrointestinal lesions.
The role of T-2 toxin-induced gastrointestinal lesions in T-2 toxin-enhanced resistance to listeriosis in mice was evaluated. The T-2 toxin-induced lesions did not cause a starvation effect sufficient to enhance resistance to listeriosis. Administration of polymyxin E markedly reduced the gram-negative intestinal microflora and did not eliminate the toxin-induced resistance to listeriosis. The T-2 toxin did not cause an increased expression of Ia surface antigens on peritoneal macrophages. Thus, toxin-induced anorexia and starvation or absorption of gram-negative intestinal bacteria and endotoxins through toxin-induced gastrointestinal lesions did not account for the enhancing effect of T-2 toxin on resistance to Listeria monocytogenes infection in mice.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003091:Colistin / Q000494:pharmacology; D004064:Digestive System / Q000187:drug effects* / Q000382:microbiology / Q000473:pathology; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007111:Immunity, Cellular / Q000187:drug effects; D008089:Listeria monocytogenes / Q000254:growth & development; D008088:Listeriosis / Q000276:immunology / Q000662:veterinary*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008813:Mice, Inbred ICR; D012717:Sesquiterpenes / Q000494:pharmacology*; D013154:Spleen / Q000382:microbiology; D013217:Starvation / Q000139:chemically induced / Q000662:veterinary; D013605:T-2 Toxin / Q000276:immunology / Q000494:pharmacology*
D000949:Histocompatibility Antigens Class II; D012717:Sesquiterpenes; D013605:T-2 Toxin; D003091:Colistin