A single dominant susceptible gene determines spontaneous development of thymoma in BUF/Mna rat.
Rats of the BUF/Mna strain developed spontaneous epithelial thymomas morphologically indistinguishable from human homologues at virtually 100% incidence. Segregation of thymoma development among crosses between BUF/Mna and ACI/NMs, which has 0% thymoma incidence, indicated that thymoma susceptibility was determined principally by a single autosomal dominant gene Tbm-1 (thymoma in BUF/Mna rats). In these crosses, another autosomal dominant or semidominant gene(s) contributed by ACI/NMs parents moderately reduced the thymoma incidence.
D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D005799:Genes, Dominant; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013945:Thymoma / Q000235:genetics*; D013953:Thymus Neoplasms / Q000235:genetics*