Anti-thrombotic effect of KC-404, a novel cerebral vasodilator.
KC-404 prevented mice from death and rats from A-V block, both induced by rapid i.v. injection of adenosine diphosphate (ADP), at high doses (5-100 mg/kg, i.v.). KC-404, at relatively lower doses (0.5-2 mg/kg, i.v.), inhibited the electroencephalographic (EEG) change in rat rapidly administered with arachidonic acid (AA) into the internal carotid artery. KC-404 (0.3-3 mg/kg, p.o.) inhibited the necrotic change of lower leg, paw or finger of rat when injected with sodium laurate into the femoral artery. KC-404 at doses up to 100 mg/kg, p.o. did not alter bleeding time in rat. Thus, KC-404 is expected to be of therapeutic value in cerebrovascular disorders accompanying thrombus in cerebral vasculature.
D000244:Adenosine Diphosphate; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids; D002561:Cerebrovascular Disorders / Q000188:drug therapy*; D004569:Electroencephalography; D006327:Heart Block / Q000139:chemically induced / Q000517:prevention & control; D007850:Lauric Acids; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013927:Thrombosis / Q000517:prevention & control*; D014665:Vasodilator Agents / Q000494:pharmacology*; D007212:Indolizines; D011720:Pyrazoles
D000244:Adenosine Diphosphate; D016718:Arachidonic Acid; D001095:Arachidonic Acids; D007850:Lauric Acids; D011725:Pyridines; D014665:Vasodilator Agents; C030358:lauric acid; C038366:ibudilast; D007212:Indolizines; D011720:Pyrazoles