Subcutaneous implantation of the spleen as a new technique for experimental induction of hepatic Schistosoma mansoni egg granulomas.
Schistosoma mansoni egg granulomas were induced in the livers of mice by injecting eggs into spleens which had been surgically exposed with their vascular beds intact. Subsequent return of the spleens to a subcutaneous site allows repeated injections of eggs into the liver if necessary.
D000818:Animals; D004195:Disease Models, Animal; D006099:Granuloma / Q000209:etiology*; D008109:Liver Diseases, Parasitic / Q000209:etiology*; D008171:Lung Diseases / Q000209:etiology; D008297:Male; D008722:Methods; D051379:Mice; D010063:Ovum; D012550:Schistosoma mansoni / Q000472:pathogenicity; D012555:Schistosomiasis mansoni / Q000150:complications; D013154:Spleen