title: Deficiency of apolipoproteins A-I and C-III and severe coronary heart disease.
abstract: A 55-year-old woman with severe coronary arteriosclerosis and skin xanthomas is described. The patient had a normal total cholesterol level of 168 mg/dl. Her level of high-density lipoprotein cholesterol was markedly reduced (3 mg/dl). On apolipoprotein analysis, apolipoproteins A-I and C-III were not detectable, and the level of apolipoprotein A-II was found to be at a low level (3.5 mg/dl). This case may possibly belong to a distinct new disease entity of deficiencies of apolipoprotein A-I and C-III in which coronary arteriosclerosis appears prematurely and severely.
mesh_terms: D016632:Apolipoprotein A-I; D053305:Apolipoprotein C-III; D001053:Apolipoproteins / Q000097:blood; D001054:Apolipoproteins A / Q000172:deficiency*; D001056:Apolipoproteins C / Q000172:deficiency*; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood / Q000172:deficiency*; D008875:Middle Aged
chemical_list: D016632:Apolipoprotein A-I; D053305:Apolipoprotein C-III; D001053:Apolipoproteins; D001054:Apolipoproteins A; D001056:Apolipoproteins C; D008055:Lipids; D008074:Lipoproteins; D008075:Lipoproteins, HDL