title: Randomized clinical investigation of Ro 15-1788, a benzodiazepine antagonist, in reversing the central effects of flunitrazepam.
abstract: In a double-blind, randomized study the efficacy of Ro 15-1788 as a benzodiazepine antagonist was evaluated in patients anaesthetized with flunitrazepam. The effects were compared with a comparable group of patients who did not receive the antagonist. Ro 15-1788 significantly reversed the sedative and hypnotic effects of flunitrazepam and reduced the degree of anterograde amnesia. No side-effects were attributable to the drug.
mesh_terms: D000759:Adjuvants, Anesthesia; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005442:Flumazenil / Q000627:therapeutic use*; D005445:Flunitrazepam / Q000037:antagonists & inhibitors*; D006801:Humans; D011229:Preanesthetic Medication; D011897:Random Allocation
chemical_list: D000759:Adjuvants, Anesthesia; D005442:Flumazenil; D005445:Flunitrazepam