A model for quantifying absorption through abnormal skin.
Techniques are available for quantitatively studying factors governing absorption through normal skin (in vivo and in vitro) but relatively little is known about the permeability of abnormal skin. We have designed and evaluated an in vivo model for quantifying absorption through abnormal skin. Absorption of [3H]mannitol and [14C]octyl benzoate was studied through altered rat skin. [3H]Mannitol penetrated normal skin much more slowly than did [14C]octyl benzoate. Abnormal skin was more permeable to [3H]mannitol and [14C]octyl benzoate, absorption was greater than 100X and greater than 2X greater, respectively, than normal. The in vivo model has been successfully used to quantify absorption through abnormal skin.
D000818:Animals; D001565:Benzoates / Q000378:metabolism; D002250:Carbon Radioisotopes; D005260:Female; D008353:Mannitol / Q000378:metabolism; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D012869:Skin Absorption; D014316:Tritium
D001565:Benzoates; D002250:Carbon Radioisotopes; D014316:Tritium; D008353:Mannitol