In vitro activity of CI-934, a new quinolone antimicrobial, against gram-positive bacteria.
The in vitro activity of CI-934, a new quinolone antimicrobial, was compared with that of ciprofloxacin against selected gram-positive bacteria. Concentrations of CI-934 required to inhibit 90% of strains (MIC90) were twofold to eightfold lower than those of ciprofloxacin. With the exception of Streptococcus faecium, all isolates were inhibited by CI-934 at concentrations less than or equal to 1.0 microgram/ml.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects; D024841:Fluoroquinolones; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000494:pharmacology*; D013291:Streptococcus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D011804:Quinolines; D002939:Ciprofloxacin; C047718:CI 934