Possible involvement of protein kinase C in the stimulation of amino acid transport by phorbol ester, platelet-derived growth factor and A23187 in Swiss 3T3 cells.
Stimulation of amino acid transport induced by phorbol-12,13-dibutyrate, platelet-derived growth factor or A23187 was not observed in cells lacking protein kinase C. On the other hand, stimulation of transport by epidermal growth factor or insulin was not affected. These results suggested that the stimulation of amino acid transport is mediated by at least two separate pathways.
D000596:Amino Acids / Q000378:metabolism*; D000621:Aminoisobutyric Acids / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D000001:Calcimycin / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D002460:Cell Line; D005347:Fibroblasts / Q000378:metabolism; D051379:Mice; D015240:Phorbol 12,13-Dibutyrate; D010703:Phorbol Esters / Q000494:pharmacology*; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D011493:Protein Kinase C / Q000502:physiology*; D012964:Sodium / Q000494:pharmacology
D000596:Amino Acids; D000621:Aminoisobutyric Acids; D010703:Phorbol Esters; D010982:Platelet-Derived Growth Factor; C100049:2-aminoisobutyric acid; D015240:Phorbol 12,13-Dibutyrate; D000001:Calcimycin; D012964:Sodium; D011493:Protein Kinase C; D002118:Calcium