MR of brain radiation injury: experimental studies in cats.
Two of six cats receiving small-field, single-dose, brain irradiation of 35 Gy with 6 MeV photons developed brain abnormalities in the irradiated area on MR images at 6 and 8 months, respectively, after treatment. The lesions were of high intensity on T2-weighted images and did not enhance after IV administration of gadolinium-DTPA. An additional lesion in one of these cats displayed high signal on T2-weighted images and enhanced on T1-weighted images after IV gadolinium-DTPA. Pathologic correlation revealed that the nonenhancing T2-weighted lesions consisted of edema or demyelinated regions without inflammation while the gadolinium-enhanced lesion demonstrated necrosis with inflammatory infiltrate. Focal brain irradiation may produce noninflammatory demyelination and necrosis. These histologic entities may be potentially distinguished on MR with IV gadolinium-DTPA.
D000818:Animals; D001930:Brain Injuries / Q000473:pathology*; D002415:Cats; D009682:Magnetic Resonance Spectroscopy; D009186:Myelin Sheath / Q000473:pathology; D009336:Necrosis; D011833:Radiation Injuries, Experimental / Q000473:pathology*