Halothane hepatitis in children.
It is often stated that halothane hepatitis in children is nonexistent or extremely rare. This syndrome occurred in seven children aged between 11 months and 15 years, one of whom, a 3 1/2 year old boy, died with fulminant hepatic failure. All the children had received multiple halothane anaesthetics (range 2-6, median 3). In all cases other causes of liver diseases were excluded, and in all but one the diagnosis was confirmed serologically by antibodies to halothane altered liver cell membrane antigens. These findings suggest that halothane hepatitis occurs in children, and the risk of halothane hepatitis should therefore be considered when choosing which agents to use in children who require multiple anaesthetics.
D000293:Adolescent; D000769:Anesthesia, Inhalation / Q000009:adverse effects*; D000906:Antibodies / Q000032:analysis; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D006221:Halothane / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male
D000906:Antibodies; D006221:Halothane