Prevention of experimental haemorrhagic septicaemia with a live vaccine.
Pasteurella multocida serotype B:3,4 isolated from a fallow deer in England was used as a vaccine to prevent haemorrhagic septicaemia. The deer strain was less virulent for calves than typical serotype B:2 of haemorrhagic septicaemia strains. It elicited antibodies in cattle that protected mice against serotype B:2 infection. The live deer vaccine containing 2 X 10(7) viable organisms per dose was used to immunise calves. Six months after vaccination, five of six calves were protected against serotype B:2 challenge. Two calves challenged nine months after vaccination survived the same challenge. The live vaccine was more efficacious than an alum precipitated vaccine in protecting calves against B:2 challenge.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001428:Bacterial Vaccines; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D006483:Hemorrhagic Septicemia / Q000517:prevention & control / Q000662:veterinary*; D008297:Male; D051379:Mice; D010325:Pasteurella / Q000276:immunology* / Q000472:pathogenicity; D010326:Pasteurella Infections / Q000662:veterinary*; D014611:Vaccination / Q000662:veterinary*; D014774:Virulence
D000914:Antibodies, Viral; D001428:Bacterial Vaccines