Modulation by thyroxine of the amount of lactase protein in the jejunum of adult rats.
Adult rats starved for 48 h received a daily injection of thyroxine over a 3-day period before they were killed. When compared to nourished animals, starvation provoked a 4- to 5-fold increase in immunoreactive lactase protein, which paralleled a similar stimulation of lactase activity in the brush border membranes of the proximal jejunum. Exogenous thyroxine completely inhibited the starvation-induced increase in immunoreactive lactase protein in both the intracellular and the brush border membranes.
D000818:Animals; D005696:Galactosidases / Q000378:metabolism*; D007583:Jejunum / Q000187:drug effects / Q000201:enzymology*; D007700:Kinetics; D008871:Microvilli / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine / Q000494:pharmacology*; D001616:beta-Galactosidase / Q000096:biosynthesis / Q000378:metabolism*
D005696:Galactosidases; D001616:beta-Galactosidase; D013974:Thyroxine