Recombinant human gamma interferon inhibits simian malaria.
Prophylactic treatment with 0.1 mg of human gamma interferon per kg (body weight) per day completely suppressed experimental infection with Plasmodium cynomolgi B sporozoites in rhesus monkeys. Treatment with lower doses partially suppressed this infection. Prophylactic treatment with human gamma interferon, however, had no protective effect against trophozoite-induced infection, suggesting that the interferon effect was limited to the exoerythrocytic stage of parasitic development.
D000818:Animals; D005260:Female; D007371:Interferon-gamma / Q000627:therapeutic use*; D008253:Macaca mulatta; D008288:Malaria / Q000517:prevention & control*; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use
D011994:Recombinant Proteins; D007371:Interferon-gamma