Resistance of 129/J mice to Schistosoma mansoni infection.
Mice of the strain 129/J bred at this Institute (WEHI 129/J) were exposed once or repeatedly to cercariae of Schistosoma mansoni and worm burdens determined. In keeping with reports of S. japonicum infection in these mice, a high level of resistance was recorded. Radio-labelled extracted antigens of S. mansoni adult worms were reacted with sera from exposed 129/J mice and infected BALB/c mice. Immunoprecipitated antigens preferentially recognized by antibodies in 129/J mice include proteins of Mr 99,000 and 21,000. Whether responses to these antigens are a cause or a consequence of resistance remains to be established.
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D007113:Immunity, Innate; D051379:Mice; D008807:Mice, Inbred BALB C; D012554:Schistosomiasis japonica / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000276:immunology*
D000947:Antigens, Helminth