title: The Drosophila virilis dopa decarboxylase gene is developmentally regulated when integrated into Drosophila melanogaster.
abstract: The dopa decarboxylase gene (Ddc) has been isolated from Drosophila virilis and introduced into the germ-line of Drosophila melanogaster by P-element mediated transformation. The integrated gene is induced at the correct stages during development with apparently normal tissue specificity, indicating that cis-acting elements required for regulation are functionally conserved between the two species. A comparison of the DNA sequences from the 5' flanking regions reveals a cluster of small (8-16 bp) conserved sequence elements within 150 bp upstream of the RNA startpoint, a region required for normal expression of the D. melanogaster Ddc gene.
mesh_terms: D000818:Animals; D001142:Aromatic-L-Amino-Acid Decarboxylases / Q000235:genetics*; D001483:Base Sequence; D004247:DNA / Q000648:ultrastructure; D004296:Dopa Decarboxylase / Q000235:genetics*; D004330:Drosophila / Q000201:enzymology / Q000235:genetics* / Q000254:growth & development; D004331:Drosophila melanogaster / Q000235:genetics*; D005796:Genes; D005809:Genes, Regulator; D013045:Species Specificity; D014170:Transformation, Genetic
chemical_list: D004247:DNA; D004296:Dopa Decarboxylase; D001142:Aromatic-L-Amino-Acid Decarboxylases