Interaction between chloroquine and indomethacin in airways smooth muscle in vivo.
The indomethacin-induced enhancement of airways smooth muscle contractility to histamine reported earlier in vitro has now been demonstrated in conscious guinea-pigs. Chloroquine, an anti-malarial drug with phospholipase A2 inhibitory activity, antagonized histamine and also reversed the indomethacin-induced enhancement. These observations indicate that histamine-induced bronchospasm in vivo is modulated by the arachidonate system and that chloroquine-type phospholipase A2 inhibitors may ameliorate such bronchospasm. These findings also explain the observed clinical benefits of chloroquine in chronic asthmatics.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001980:Bronchi / Q000187:drug effects* / Q000502:physiology; D002738:Chloroquine / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D054467:Phospholipases A2; D014132:Trachea / Q000187:drug effects* / Q000502:physiology
D001095:Arachidonic Acids; D016718:Arachidonic Acid; D006632:Histamine; D002738:Chloroquine; D010741:Phospholipases A; D054467:Phospholipases A2; D007213:Indomethacin