Determination of in vivo concentration-time profiles of chlorhexidine and noxythiolin bladder irrigations.
The in vivo concentration-time profiles of chlorhexidine and noxythiolin bladder irrigations were determined by utilizing high-performance liquid chromatography techniques following a once daily irrigation. A total of 14 chlorhexidine irrigations established a mean concentration of 0.006% w/v, 2-3 h post irrigation. A total of 12 noxythiolin irrigations established a mean concentration of 0.266% w/v, 2-3 h post irrigation, which correlated to a mean formaldehyde concentration of 0.0119% w/v at 2-3 h, as estimated from N-methylthiourea. For both solutions the minimum inhibitory concentration was exceeded for up to 5 h post irrigation, which is sufficient contact time to establish a total kill, thus indicating the possibility that a once daily irrigation may be appropriate in asymptomatic bacteriuria which utilizes either chlorhexidine or noxythiolin.
D000368:Aged; D001437:Bacteriuria / Q000378:metabolism; D002710:Chlorhexidine / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D009677:Noxythiolin / Q000652:urine*; D007507:Therapeutic Irrigation; D013890:Thiourea / Q000031:analogs & derivatives*; D001743:Urinary Bladder / Q000187:drug effects* / Q000378:metabolism
D009677:Noxythiolin; D013890:Thiourea; D002710:Chlorhexidine