Effects of cimetidine on jejunostomy effluents in patients with severe short-bowel syndrome.
The effect of the H2-receptor blocking agent cimetidine on jejunal effluent was examined in eight short-bowel patients with high-output jejunostomies. Stool mass and faecal excretion of sodium and potassium were significantly reduced by intravenous injection of 400 mg cimetidine four times a day. The amount of calcium, magnesium, phosphate, zinc, and fat in jejunostomy effluent did not change significantly. Cimetidine may be considered an antidiarrhoeal drug in extensively small-bowel-resected patients with a jejunostomy and may reduce the need for parenteral saline supply in these patients.
D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000601:surgery; D050356:Lipid Metabolism; D008286:Malabsorption Syndromes / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D012778:Short Bowel Syndrome / Q000188:drug therapy* / Q000628:therapy; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D002927:Cimetidine