[New data on the hormonal requirement of the pregnant rabbit: partial pregnancies and fetal abnormalities after treatment with a hormonal antagonist given at a sub-abortive dosage].
Evolution of pregnancy in rabbits depends upon ovarian progesterone. A deficiency in ovarian hormones was observed a long time ago to result either in abortion or in "partial pregnancy" or even in fetal anomalies. Administration to pregnant rabbits, from day 11 on, of a hormonal antagonist known for its anti-progesterone activity, RU486, at a sub-abortive dosage, reproduces the effects of ovarian hormone deficiencies.
D000014:Abnormalities, Drug-Induced; D000019:Abortifacient Agents / Q000633:toxicity*; D000021:Abortifacient Agents, Steroidal / Q000633:toxicity*; D000022:Abortion, Spontaneous; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004963:Estrenes / Q000633:toxicity*; D005260:Female; D015735:Mifepristone; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011374:Progesterone / Q000037:antagonists & inhibitors; D011817:Rabbits
D000019:Abortifacient Agents; D000021:Abortifacient Agents, Steroidal; D004963:Estrenes; D015735:Mifepristone; D011374:Progesterone
Nouvelles données sur le besoin hormonal de la lapine gestante: grossesses partielles et anomalies foetales après traitement par un antagoniste hormonal à dose sub-abortive.