Cerebral glucose metabolism in the Lennox-Gastaut syndrome.
We used positron emission tomography with fluorine 18-labeled 2-deoxyglucose to study cerebral glucose metabolism in 10 patients with Lennox-Gastaut syndrome who had normal neuroradiological studies. The scans showed decreased metabolic rates relative both to those in the caudate nucleus and to normal control values in 3 patients whose seizures began before the age of 1, as well as in a patient with hyperprolinemia. No patient had a region of persistent focal hypometabolism. Metabolic rates increased in parallel with increased electroencephalographic discharges in 1 patient; 3 patients had lower metabolic rates when the electroencephalogram showed epileptiform discharges and while the patients were taking barbiturates.
D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism*; D002648:Child; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D013577:Syndrome; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
D000927:Anticonvulsants; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose