Gold induced thrombocytopenia: 12 cases and a review of the literature.
Gold induced thrombocytopenia is immune mediated, with the production of platelet associated IgG leading to peripheral platelet destruction. An association with HLA-DR3 has been demonstrated. Corticosteroid therapy is effective in treatment, although other modes of therapy may be as efficacious.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology; D006046:Gold / Q000009:adverse effects* / Q000627:therapeutic use; D006052:Gold Sodium Thiomalate / Q000009:adverse effects / Q000627:therapeutic use; D006684:HLA-DR Antigens / Q000032:analysis; D015803:HLA-DR3 Antigen; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology
D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D007074:Immunoglobulin G; D006052:Gold Sodium Thiomalate; D006046:Gold