[Comparative hemodynamics action of glycero-2-nitrate and glycerol trinitrate in various species and the pharmacokinetics of glycerol-2-nitrate in the dog].
Comparative Hemodynamic Activity of Glyceryl 2-Nitrate and Glyceryl Trinitrate in Various Species and Pharmacokinetics of Glyceryl 2-Nitrate in Dog A single dose of glyceryl 2-nitrate (G-2-N) had practically identical hypotensive and cardiovascular activity when administered intravenously or enterally to the anaesthetized rabbit, cat or dog. In all three species the hypotensive and also cardiovascular activity of G-2-N lasted much longer than that of glyceryl trinitrate (GTN, Nitro Mack). In the rabbit, cat and dog enterally active doses of GTN were 500-1000 times greater than parenterally active doses. In all species enterally administered GTN was about 8 times more active than enterally administered G-2-N. G-2-N is 100% bioavailable in the conscious dog.
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003331:Coronary Vessels / Q000187:drug effects; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D005996:Nitroglycerin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits; D013045:Species Specificity
C051753:glycerol-2-nitrate; D005996:Nitroglycerin
Vergleichende hämodynamische Wirkung von Glycerol-2-nitrat und Glyceroltrinitrat an verschiedenen Tierarten und Pharmakokinetik von Glycerol-2-nitrat am Hund.