Frozen recovered red cell boosting of female donors for anti-D-production.
A selected group of women previously immunized in pregnancy by the Rh(D) antigen were boosted with 0.5 ml of Rh(D)-positive frozen recovered red cells from an accredited donor panel. The response was prompt and sustained and increased the anti-D content by almost 10-fold. In spite of the reduced rate of clinical immunisation to the Rh(D) antigen, it was possible to recruit females with anti-D, acquired in pregnancy, for secondary boosting and a programme is recommended which maximizes efficiency and safety.
D000328:Adult; D001782:Blood Donors; D001793:Blood Preservation; D001803:Blood Transfusion; D017707:Erythrocyte Transfusion; D005260:Female; D005615:Freezing; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods*; D007518:Isoantibodies / Q000096:biosynthesis / Q000302:isolation & purification*; D008875:Middle Aged; D012203:Rh Isoimmunization / Q000276:immunology*; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D012449:Safety
D007518:Isoantibodies; C033242:RH-antibodies; D012204:Rh-Hr Blood-Group System