Routine synthesis of L-[18F]6-fluorodopa with fluorine-18 acetyl hypofluorite.
The synthesis of L-[18F]6-fluorodopa (2.4-10.6 mCi) was done by passing gaseous [18F]acetyl hypofluorite through a solution of L-methyl-N- acetyl-[beta-(3-methoxy-4-acetoxyphenyl)]alaninate in acetic acid at room temperature followed by the hydrolysis of the intermediate products with concentrated hydriodic acid. The desired fluorodopa isomer was isolated in 8% EOB radiochemical yield by high performance liquid chromatography in an overall synthesis time of 100 min.
D000085:Acetates; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D004952:Esters; D005461:Fluorine; D007202:Indicators and Reagents; D008722:Methods; D011868:Radioisotopes
D000085:Acetates; D004952:Esters; D007202:Indicators and Reagents; D011868:Radioisotopes; D005461:Fluorine; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine; C040801:acetyl hypofluorite