[Surface membrane differentiation antigens of the lymph node lymphocytes in nonspecific lymphoproliferative reactions and lymphogranulomatosis in children].
Monoclonal antibodies ICO and OKT, OKM5, C-ALLA have been used to investigate surface lymphocyte antigens in normal (9), reactive (27) lymph nodes and in lymphogranulomatosis (9) in children. The study has shown that the number of lymphocytes with T and B markers is 45% in normal lymph nodes; OKT4/OKT8 is 0.9. In reactive lymph nodes all lymphocytes have T and B markers; OKT4/OKT8 is, 1.5. T-cell (OKT3+, OKT11+) or B-cell (sIg+, ICO-1+) type differentiation is preferable. B-cell type proliferation with a high number of ICO-1+ lymphocytes appeared in lymph nodes of 4 patients with lymphogranulomatosis. Polyclonal proliferation and differentiation were observed in other 5 children. No correlation between immunology and histologic types of the disease was revealed.
D000293:Adolescent; D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis; D000944:Antigens, Differentiation, B-Lymphocyte; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D006965:Hyperplasia / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology* / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology*; D008232:Lymphoproliferative Disorders / Q000276:immunology*; D051379:Mice
D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D000954:Antigens, Surface
Differentsirovochnye antigeny poverkhnostnykh membran limfotsitov limfaticheskikh uzlov pri nespetsificheskikh limfoproliferativnykh reaktsiiakh i limfogranulematoze u deteĭ.