[Congestive cardiomyopathy in addiction to clobenzorex, an anorexigenic drug].
Cardiac failure caused by high doses of amphetamine-like drugs is rare. We report a case of decompensated congestive cardiomyopathy occurring in a 29 year old woman addicted to clobenzorex (Dinintel). This patient had been taking 5 to 7 capsules per day for 5 years. No other cause of cardiac failure was detected. A rapid improvement was obtained by digitalis and diuretic therapy; no further episodes of cardiac failure were observed after one year. However, the drug could not be completely withdrawn and echocardiography has shown increasing left ventricular dilatation. The possible mechanisms of amphetamine induced myocardial toxicity are discussed and the analogy with the group of adrenergic cardiomyopathies is underlined.
D000328:Adult; D000662:Amphetamines / Q000009:adverse effects*; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D006801:Humans; D011379:Prognosis; D019966:Substance-Related Disorders / Q000150:complications*
D000662:Amphetamines; C000490:clobenzorex
Cardiomyopathie congestive au cours d'une toxicomanie à un anorexigène, le clobenzorex.