The central amygdala and immobilization stress-induced gastric pathology in rats: neurotensin and dopamine.
Bilateral microinjections of neurotensin (3, 10 and 30 micrograms) into the central amygdala had a dose-related attenuating effect on cold-restraint gastric ulcers in rats. Similar inhibitory effects were also observed with intra-amygdalar dopamine (3, 10 and 30 micrograms). Pretreatment with 6-hydroxydopamine (10 micrograms) or haloperidol (1 mg/kg), however, reversed the ulcer attenuating effect of neurotensin. The results indicate that the central amygdala is important in the mediation of the cytoprotective effects of neurotensin and dopamine.
D000679:Amygdala / Q000503:physiopathology*; D000818:Animals; D003080:Cold Temperature; D004298:Dopamine; D006220:Haloperidol; D006892:Hydroxydopamines; D008297:Male; D009496:Neurotensin; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000209:etiology* / Q000503:physiopathology; D013312:Stress, Physiological / Q000150:complications* / Q000503:physiopathology
D006892:Hydroxydopamines; D009496:Neurotensin; D016627:Oxidopamine; D006220:Haloperidol; D004298:Dopamine