Antibody-mediated suppression of erythropoiesis in dogs with red blood cell aplasia.
Eight dogs with acquired RBC aplasia were studied. Unfractionated sera and serum immunoglobulin G fractions were examined for the presence of erythroid progenitor cell inhibitors. A serum immunoglobulin G inhibitor directed against precursors of erythroid colony-forming units was detected in 3 of 5 dogs that were direct Coombs' test-negative and in 1 of 3 dogs that were direct Coombs' test-positive. Sera from these dogs were treated with binary ethyleneimine to inactivate any viruses present. The inhibitory effects of the treated serum on erythroid colony-forming units was not ameliorated.
D000818:Animals; D004283:Dog Diseases / Q000097:blood / Q000209:etiology* / Q000276:immunology; D004285:Dogs; D004920:Erythropoiesis; D007074:Immunoglobulin G / Q000502:physiology*; D012010:Red-Cell Aplasia, Pure / Q000097:blood / Q000209:etiology / Q000276:immunology / Q000662:veterinary*
D007074:Immunoglobulin G