Drug therapy in the management of acute renal failure.
Pharmacologic intervention aimed at altering the natural history of acute renal failure is a routine practice without scientific support of efficacy. Oliguria has become a separate disease entity with an apparent disregard for the underlying condition that caused it. Volume expansion is clearly beneficial in preventing many volume depleted patients from progressing to acute renal failure. While mannitol and furosemide have been used to "convert" oliguric acute renal failure to the more easy to manage non-oliguric acute renal failure, published reports suggest that responders were not as ill as non-responders. The use of dopamine to increase urine flow in patients with established acute renal failure is the current fashion, but there is little evidence that this drug raises the glomerular filtration rate or shortens the course of acute renal failure. These pharmacologic therapies increase the complexity and cost of care with little tangible evidence of benefit to the patient or the physician caring for the patient.
D058186:Acute Kidney Injury / Q000188:drug therapy*; D000818:Animals; D001810:Blood Volume / Q000187:drug effects; D004232:Diuretics / Q000627:therapeutic use; D004285:Dogs; D005665:Furosemide / Q000627:therapeutic use; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D008138:Loop of Henle / Q000187:drug effects; D008353:Mannitol / Q000627:therapeutic use; D051381:Rats; D012079:Renal Circulation / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects
D004232:Diuretics; D008353:Mannitol; D005665:Furosemide