Role of the preoptic area in the neuroendocrine regulation of reproduction: an analysis of functional preoptic homografts.
In conclusion, POA grafts that contain GnRH cell bodies are capable of correcting many of the reproductive deficiencies that are associated with a genetic failure to produce GnRH. The previously infertile animals exhibit steroidogenesis and gametogenesis. Ovulations associated with mating suggest that the grafted GnRH cells are responding to some environmental cues and may be under some regulation by the host brain. Although the grafts contain tissue that may have sexually dimorphic characteristics, the studies with the hpg mice have not yet revealed any effects of the grafts that could be related to the sex of the donor.
D000818:Animals; D005260:Female; D005640:Follicle Stimulating Hormone / Q000502:physiology*; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology; D007986:Luteinizing Hormone / Q000502:physiology*; D008297:Male; D008425:Maternal Behavior; D051379:Mice; D008817:Mice, Mutant Strains; D011301:Preoptic Area / Q000196:embryology / Q000502:physiology* / Q000637:transplantation; D012098:Reproduction; D012727:Sex Characteristics; D012726:Sexual Behavior, Animal / Q000502:physiology
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone