title: Comparison of monoglyceryl acetoacetate and glucose as parental energy substrate after experimental trauma.
abstract: The effects of ketone bodies and glucose on nitrogen balance and liver protein synthesis were studied in rat after experimental trauma. Energy was delivered intravenously as either monoglyceryl acetoacetate (MA; 87.5% of total energy input) or glucose (G). The isocaloric infusions (132 kcal/kg/day) were started after recovery from anaesthesia and continued for 2 days. The liver protein synthesis was then measured in vitro by perfusion with 14C-leucine. The infusion of MA resulted in a more negative cumulative nitrogen balance (MA: -2.31 +/- 0.26 g N/kg, G: -1.32 +/- 0.43 g N/kg/48 h; mean +/- SD) and liver protein synthesis (MA: 43.4 +/- 17.2, G: 71.1 +/- 15.2; arbitrary units, mean +/- SD). The results indicate no benefits from MA during the immediate post-traumatic period.
mesh_terms: D000090:Acetoacetates / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D004734:Energy Metabolism; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism*; D005989:Glycerides / Q000008:administration & dosage / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism; D010288:Parenteral Nutrition; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D014947:Wounds and Injuries / Q000378:metabolism*
chemical_list: D000090:Acetoacetates; D005989:Glycerides; C020417:monoacetoacetin; D005947:Glucose; D009584:Nitrogen