Human IgG antibody responses to grass pollen antigens: effects of immunotherapy and comparison of serum and secretory profiles.
IgG antibody responses, induced by individual temperate grass pollen allergens in atopic subjects, have been studied by an SDS-PAGE immunoprecipitation technique. These were shown to be of a complex nature and variable between individuals. Profiles obtained with serum and nasal secretions from the same individual were qualitatively similar. Immunotherapy with a glutaraldehyde-modified grass pollen extract, Pollinex, increased the level of specific IgG to three clinically significant grass pollen allergens but did not markedly change the overall pattern of response.
D000485:Allergens / Q000627:therapeutic use*; D000917:Antibody Formation; D052179:Antigens, Plant / Q000627:therapeutic use; D004338:Drug Combinations / Q000627:therapeutic use; D005976:Glutaral / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007167:Immunotherapy; D007457:Iodine Radioisotopes; D009297:Nasal Mucosa / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts; D011058:Pollen / Q000276:immunology* / Q000627:therapeutic use; D014443:Tyrosine / Q000627:therapeutic use
D000485:Allergens; D052179:Antigens, Plant; D004338:Drug Combinations; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; D010936:Plant Extracts; D014443:Tyrosine; C014155:Parietaria judaica pollen; D005976:Glutaral