title: Drug-resistant tuberculosis in Sierra Leone.
abstract: Culture and sensitivity tests were performed on tubercle bacilli from patients with tuberculosis attending a provincial general hospital in Sierra Leone, who appeared clinically to have drug-resistant infections. Amongst the general intake of patients from 1978 to 1984 there was a 10.5% incidence of isoniazid resistance, with 7.7% of patients having strains resistant to both streptomycin and isoniazid, 1.3% resistant to rifampicin, and 0.8% resistant to ethambutol. Multiple drug resistance was more frequent than single drug resistance. This high incidence is largely due to inadequate and irregular supplies of first line drugs.
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004977:Ethambutol / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D012293:Rifampin / Q000494:pharmacology / Q000627:therapeutic use; D012807:Sierra Leone; D013307:Streptomycin / Q000494:pharmacology / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin