Cysteine-rich regions conserved in amino-terminal halves of raf gene family products and protein kinase C.
The predicted amino acid sequences of rat c-raf and A-raf products were subjected to homology search against other known amino acid sequences. We found that characteristic, cysteine-rich regions present in the amino-terminal halves of c-raf and A-raf products had striking homologies with the cysteine-rich regions present in protein kinase C. These cysteine-rich regions had been shown to be deleted in the activated raf products and in the catalytically active protein kinase C produced by proteolysis. These facts suggest the significance of the cysteine-rich regions of raf products as well as those of protein kinase C in the regulation of kinase activities.
D000595:Amino Acid Sequence; D000818:Animals; D003545:Cysteine / Q000032:analysis*; D004789:Enzyme Activation; D011493:Protein Kinase C / Q000032:analysis*; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D051381:Rats
D011518:Proto-Oncogene Proteins; D011493:Protein Kinase C; D003545:Cysteine