title: Effect of prostacyclin on renal kallikrein release in man.
abstract: The aim of this research was to study exogenous prostacyclin effect on urinary kallikrein excretion (UKK) in man, to define whether prostacyclin-induced renin release and/or endogenously released cyclooxygenase products were responsible for prostacyclin-induced enhancement of UKK, to determine furosemide effect on UKK. Prostacyclin was infused in eight healthy men and repeated after propranolol and indomethacin treatment. Prostacyclin caused a dose-dependent increase of UKK. Pretreatment with propranolol and indomethacin did not affect prostacyclin-induced enhancement of UKK, although it reduced absolute values of plasma renin activity. Furosemide increased UKK and simultaneously urinary 6-keto-prostaglandin F1 alpha. We conclude that prostacyclin induces an increase in UKK in a dose-dependent manner; furosemide-induced renal prostacyclin synthesis is temporally related to enhancement of UKK; partial dissociation of UKK from plasma renin activity under propranolol and indomethacin treatment and in response to furosemide might suggest a direct effect of prostacyclin on UKK.
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000494:pharmacology; D000328:Adult; D011464:Epoprostenol / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007610:Kallikreins / Q000378:metabolism* / Q000652:urine; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D012083:Renin / Q000097:blood
chemical_list: D015121:6-Ketoprostaglandin F1 alpha; D005665:Furosemide; D011433:Propranolol; D011464:Epoprostenol; D007610:Kallikreins; D012083:Renin; D007213:Indomethacin