title: Expression of c-fos, c-myb, and c-myc in human monocytes: correlation with monocytic differentiation.
abstract: Terminal differentiation of human monocytic leukemia cells (THP-1 cells) was associated with the induction of c-fos, the down regulation of c-myb, and no significant change in the level of c-myc expression. Gamma interferon, which resulted in a slight decrease in c-myb but no change in c-fos or c-myc expression, had a transient antiproliferative effect without a morphological or functional differentiation of THP-1 cells. Resting human peripheral blood monocytes have a high c-fos, a low c-myc, and no detectable c-myb expression. These findings suggest that a switch in c-fos/c-myb expression is associated with the terminal differentiation of cells of the monocytic lineage.
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D003101:Collodion; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D008264:Macrophages / Q000254:growth & development / Q000502:physiology; D009000:Monocytes / Q000166:cytology* / Q000187:drug effects; D009857:Oncogenes / Q000187:drug effects*; D011519:Proto-Oncogenes / Q000187:drug effects*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014212:Tretinoin / Q000494:pharmacology
chemical_list: D014212:Tretinoin; D007371:Interferon-gamma; D003101:Collodion; D013755:Tetradecanoylphorbol Acetate