Influence of microinjection of glucagon into ventromedial hypothalamus on acetate metabolism in liver slices of rabbit.
Glucagon was injected directly into the ventromedial hypothalamic nuclei (VMH) of rabbits, and changes in hepatic acetate metabolism were studied. The injection of 3 ng glucagon into the VMH of intact rabbits increased the rates of 14C transfer from 14C-1-acetate into CO2, glucose and ketone bodies but decreased those into cholesterol ester, triglyceride, free cholesterol, free fatty acids and phospholipids. However, after glucagon injection into the VMH of rabbits with VMH lesions and the parietal cortex of intact rabbits, hepatic acetate metabolism did not differ from that of the control rabbits, which received saline injection into the same brain regions. These observations support the hypothesis that the VMH are parts of a glucagon-sensitive brain regulator system in the hepatic acetate metabolism.
D000085:Acetates / Q000378:metabolism*; D019342:Acetic Acid; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D005934:Glucagon / Q000008:administration & dosage / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D007033:Hypothalamus, Middle / Q000187:drug effects* / Q000502:physiology; D007657:Ketone Bodies / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008845:Microinjections; D011817:Rabbits
D000085:Acetates; D007657:Ketone Bodies; D002245:Carbon Dioxide; D005934:Glucagon; D005947:Glucose; D019342:Acetic Acid