Cross-reactions in cell-mediated immunity to Salmonella causing enteric fever.
Cross-reactivity in a delayed-type hypersensitivity (DH) response was studied in mice immunised with live Salmonella typhi, S. paratyphi A and S. paratyphi B. Extensive cross-reactions outside the serogroup limits were observed. The ability of DH cross-reacting and non-cross-reacting sonicates to generate activated macrophages was studied in mice immunised 3 months earlier with S. paratyphi B. Whereas DH cross-reacting S. poona sonicate generated activated macrophages the non-cross-reacting S. typhi sonicate did not. To determine whether infections due to diarrhoea-causing salmonellae generated cross-reactive cell-mediated immune responses against enteric fever-causing organisms, similar reverse experiments were performed in mice immunised with S. enteritidis. S. paratyphi A sonicate generated both effector responses, i.e., DH and activated macrophages.
D000818:Animals; D003429:Cross Reactions; D006968:Hypersensitivity, Delayed; D007114:Immunization; D008262:Macrophage Activation; D051379:Mice; D010284:Paratyphoid Fever / Q000276:immunology; D012475:Salmonella / Q000276:immunology*; D012481:Salmonella Infections, Animal / Q000276:immunology; D012477:Salmonella enteritidis / Q000276:immunology; D012482:Salmonella paratyphi A / Q000276:immunology*; D012484:Salmonella paratyphi B / Q000276:immunology; D012485:Salmonella typhi / Q000276:immunology*; D014435:Typhoid Fever / Q000276:immunology