In vitro effects of alpha-bromopalmitate on metabolism of essential fatty acids studied in isolated rat hepatocytes: sex differences.
alpha-Bromopalmitate was shown to have a far more pronounced effect on metabolism of labelled linoleic acid (18:2, n-6) and arachidonic acid (20:4, n-6) in isolated liver cells from female rats than in those from males. alpha-Bromopalmitate decreased triacylglycerol synthesis with a concomitant accumulation of fatty acid in diacylglycerol, indicating that the acylation of diacylglycerol is affected by alpha-bromopalmitate.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D004951:Esterification; D005228:Fatty Acids, Essential / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D010168:Palmitates / Q000494:pharmacology*; D010169:Palmitic Acids / Q000494:pharmacology*; D051381:Rats; D012727:Sex Characteristics
D001095:Arachidonic Acids; D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D010168:Palmitates; D010169:Palmitic Acids; C022776:2-bromopalmitate; D016718:Arachidonic Acid; D019787:Linoleic Acid