Induced precipitation of calcium-oxalate crystals and its prevention in laboratory animals.
Induced precipitation of Ca-oxalate crystals and the possibility of its prevention were studied in dogs. In the first phase of the experiments precipitation of Ca-oxalate crystals in canine renal tubules was induced by intraperitoneal administration of Na-glyoxylate. Preventive medication (lipoic acid, vitamin B1, Milurit), applied in the second phase, resulted in a significant depression of induced precipitation. The successful experiments serve as a basis for clinical research aimed at a preventive medication of recurrent Ca-oxalate stone formation.
D000818:Animals; D002129:Calcium Oxalate / Q000032:analysis; D004285:Dogs; D006038:Glyoxylates; D007669:Kidney Calculi / Q000032:analysis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D012008:Recurrence; D013831:Thiamine / Q000627:therapeutic use; D008063:Thioctic Acid / Q000627:therapeutic use
D006038:Glyoxylates; D002129:Calcium Oxalate; D008063:Thioctic Acid; D013831:Thiamine