Phenotype correction of Ir-genic control of immune response to (T,G)-A-L conjugated to synthetic polyelectrolytes.
Experiments in CBA (H-2k) and C57BL/6 (H-2b) strains of mice have shown (T,G)-A-L covalently bound to synthetic polyelectrolytes possessing immunoadjuvant effect to induce a pronounced antibody and cell-mediated immune response irrespective of murine genotype. When conjugated to the polyelectrolytes (T,G)-A-L was also found to acquire the properties of a highly immunogenic thymus-independent antigen. Thus, (T,G)-A-L-synthetic polyelectrolytes conjugates manifested the effects of highly immunogenic thymus-independent antigens inducing a potent Ir-1-independent immune response. It provided for the transformation of genetically low responder individuals into high responder ones.
D000818:Animals; D005802:Genes, MHC Class II; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D007075:Immunoglobulin M / Q000032:analysis; D051379:Mice; D008808:Mice, Inbred CBA / Q000235:genetics / Q000276:immunology; D008815:Mice, Inbred Strains / Q000235:genetics / Q000276:immunology; D010455:Peptides / Q000276:immunology*; D010641:Phenotype; D013154:Spleen / Q000276:immunology
D007075:Immunoglobulin M; D010455:Peptides; C021759:(T,G)-A-L