title: Comparison of effects of fentanyl and alfentanil on intra-ocular pressure. A double-blind controlled trial.
abstract: The effects of fentanyl and alfentanil on intra-ocular pressure during anaesthesia were investigated in 50 consecutive patients in a double-blind controlled trial. Both drugs produced a significant reduction in intraocular pressure (p less than 0.01). Alfentanil produced significantly greater reduction (48.5 percent) than fentanyl (28.6 percent) (p less than 0.01). A small but statistically significant reduction in arterial pressure (15 percent approximately) and heart rate (18 percent approximately), were observed with both agents, but no significant differences between them were noted. It is suggested that alfentanil may be a suitable alternative to fentanyl in ophthalmic anaesthesia.
mesh_terms: D000759:Adjuvants, Anesthesia / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D015760:Alfentanil; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D013997:Time Factors
chemical_list: D000759:Adjuvants, Anesthesia; D015760:Alfentanil; D005283:Fentanyl