An acute leukaemia augured before clinical signs by blood group antigen abnormalities and low levels of A and H blood group transferase activities in erythrocytes.
A mixed field agglutination pattern with anti-A reagents and very low levels of A and H blood group antigen specific transferase activities were found in the erythrocytes of a 4-year-old girl who presented no clinical signs of haematological disease. Blood and marrow examination displayed some features consistent with a moderate dysmyelopoietic state. 18 months later an acute myeloblastic leukaemia confirmed the suspected haematological malignancy.
D000017:ABO Blood-Group System; D000208:Acute Disease; D002675:Child, Preschool; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005647:Fucosyltransferases / Q000032:analysis; D005700:Galactosyltransferases / Q000032:analysis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000209:etiology; D009190:Myelodysplastic Syndromes / Q000097:blood* / Q000150:complications; D017350:N-Acetylgalactosaminyltransferases; D000097631:Galactoside 2-alpha-L-fucosyltransferase
D000017:ABO Blood-Group System; D005647:Fucosyltransferases; D005700:Galactosyltransferases; D017350:N-Acetylgalactosaminyltransferases; D000097631:Galactoside 2-alpha-L-fucosyltransferase; C003742:UDPgalactosamine-galactose acetylgalactosaminyltransferase