Conditional hyperthermia in response to atropine associated with a hypothermic drug.
In a set of experiments designed to examine learned associations between drug states, atropine sulfate (10 mg/kg) elicited a conditional hyperthermia in rats following ten treatment sessions in which the drug was paired with either chlorpromazine hydrochloride (10 mg/kg) or ethanol (2.3 g/kg), both hypothermia-inducing agents. Atropine methyl nitrate, a quaternary analogue with similar peripheral effects but little central action, was ineffective as a cue in this situation. These experiments demonstrated that a sequential pairing of drug states can yield a change in an organism's response to the cue drug (the first drug in the sequence).
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D002746:Chlorpromazine / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects; D004777:Environment; D000431:Ethanol / Q000494:pharmacology; D005334:Fever / Q000139:chemically induced*; D008297:Male; D051381:Rats; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000431:Ethanol; D001285:Atropine; D002746:Chlorpromazine