Effect of the beta-2 adrenergic agonist fenoterol on the release of leukotrienes and prostaglandin D2 from human lung parenchyma.
Ca++-ionophore and antigen challenge of human lung fragments caused a massive release of leukotrienes, whose relative proportions varied considerably and were dependent on the experimental conditions. A broncho-selective beta 2-adrenoceptor agonist fenoterol was able to prevent the antigen-induced leukotriene release completely, whereas the Ca++-ionophore induced leukotriene release was only moderately inhibited. The HPLC data were confirmed by SRS-A bioassay.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D000001:Calcimycin / Q000494:pharmacology; D005280:Fenoterol / Q000494:pharmacology*; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D015230:Prostaglandin D2; D011457:Prostaglandins D / Q000378:metabolism*; D013189:SRS-A / Q000378:metabolism*
D001095:Arachidonic Acids; D011457:Prostaglandins D; D013189:SRS-A; D005280:Fenoterol; D016718:Arachidonic Acid; D000001:Calcimycin; D015230:Prostaglandin D2