Intestinal permeability to [51Cr]EDTA in children with cystic fibrosis.
Intestinal permeability was investigated in 14 children with cystic fibrosis making use of [51Cr]EDTA as probe molecule. Ten normal young adults and 11 children served as controls. After oral administration of [51Cr]EDTA, 24 h urine was collected. Urinary radioactivity was calculated and results expressed as percentage of oral dose excreted in 24 h urine. Mean and SEM were as follows: 2.51 +/- 0.21, 2.35 +/- 0.24, and 13.19 +/- 1.72 for control children, normal adults, and cystic fibrosis patients, respectively. The permeability differences between cystic fibrosis patients and either control children or control adults are significant (p less than 0.001).
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002860:Chromium Radioisotopes / Q000652:urine; D003550:Cystic Fibrosis / Q000503:physiopathology*; D004492:Edetic Acid / Q000652:urine; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D010539:Permeability
D002860:Chromium Radioisotopes; D004492:Edetic Acid