Post-ischemic renal function after kidney protection with the HTK-solution of Bretschneider.
The cardioplegic solution HTK of Bretschneider was used for canine kidney protection. The kidneys were perfused with this solution for 6-10 min prior to the induction of ischemia. The kidneys were left in-situ for 60, 90, 120 and 135 min ischemia time at a temperature of 25-34 degrees C (n = 13). As a control group we used unilateral nephrectomized dogs (n = 9). After unilateral nephrectomy an elevated plasma creatinine in comparison to preoperative values was observed. After 60 and 90 min under HTK-protection the postoperative plasma creatinine was not elevated compared to the control group. After 120 min of ischemia creatinine level was slightly increased to an average of 2.1 mg% on the first and second postoperative day. These experiments indicate the protective effect of the cardioplegic solution for canine kidney preservation in situ.
D000818:Animals; D003404:Creatinine / Q000097:blood; D004285:Dogs; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D007511:Ischemia / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D007677:Kidney Function Tests; D008297:Male; D008353:Mannitol / Q000494:pharmacology*; D009392:Nephrectomy; D011189:Potassium Chloride / Q000494:pharmacology*; D011343:Procaine / Q000494:pharmacology*
C039984:Bretschneider cardioplegic solution; D008353:Mannitol; D011343:Procaine; D011189:Potassium Chloride; D003404:Creatinine; D005947:Glucose