The acute phase response to inflammation: the role of monokines in changes in liver glycoproteins and enzymes of glycoprotein metabolism.
The role of monocyte derived factors in the acute phase response to inflammation is discussed. The kinetics of response of alpha 1-acid glycoprotein, sialyltransferase and albumin to a rat monokine preparation is described. There was an increase in synthesis of alpha 1-acid glycoprotein and sialyltransferase and a decrease in albumin synthesis following administration. However, the kinetics of response of sialyltransferase to the monokine was much slower than was found for the other two proteins. The possibility that sialyltransferase responds to a different monokine compared to the other acute phase proteins is discussed.
D000210:Acute-Phase Reaction / Q000097:blood*; D000818:Animals; D006023:Glycoproteins / Q000378:metabolism*; D007249:Inflammation / Q000097:blood*; D007700:Kinetics; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D015846:Monokines; D009961:Orosomucoid / Q000097:blood; D011506:Proteins / Q000008:administration & dosage / Q000502:physiology*; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism; D012799:Sialyltransferases / Q000378:metabolism; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase
D006023:Glycoproteins; D015846:Monokines; D009961:Orosomucoid; D011506:Proteins; D012709:Serum Albumin; D012799:Sialyltransferases; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase