title: Benzodiazepine antagonist Ro 15-1788. Antagonism of diazepam sedation in outpatients undergoing gastroscopy.
abstract: In a double-blind, randomised trial the efficacy and safety of Ro 15-1788, a new benzodiazepine antagonist, was assessed in forty adults undergoing gastroscopy under diazepam sedation. Criteria of efficacy were the degree of sedation and anterograde amnesia. There was a significantly faster recovery of the patients after the injection of 0.6-1.0 mg of Ro 15-1788 than after placebo. Patients were awake shortly after Ro 15-1788, but remained drowsy or asleep after placebo administration. There were no side effects of note.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000647:Amnesia; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000037:antagonists & inhibitors*; D004311:Double-Blind Method; D005260:Female; D005442:Flumazenil / Q000494:pharmacology*; D005773:Gastroscopy; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D006993:Hypnotics and Sedatives; D005442:Flumazenil; D003975:Diazepam