[Three cases of adenocarcinoma of the lower esophagus and cardia showing marked regression after radiotherapy with FT-207].
Three cases of adenocarcinoma of the lower esophagus and cardia which is considered to be difficult to control by radiotherapy alone, were given radical irradiation combined with FT-207 suppository. Dosages of radiation and FT-207 were 70 Gy/35 f and 1.5 g/day (1 case) or 1.0 g/day (2 cases), respectively. The treatment was successful locally; dysphagia was improved in all cases and 1 case has shown no recurrence for a period of two and a half years. Side effects were leukopenia and hemorrhagic esophagitis in the case given 1.5 g/day of FT-207, but these were cured by conservative therapy. These results emphasize that radiotherapy combined with anticancer drugs should be considered as a local therapy for inoperable adenocarcinoma of the lower esophagus and cardia.
D000230:Adenocarcinoma / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D000368:Aged; D002299:Cardia; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D005641:Tegafur / Q000627:therapeutic use*
D005641:Tegafur