title: Effect of amino acid intake on brush-border membrane uptake of sulfur amino acids.
abstract: Alterations in the intake of sulfur amino acids (SAA) changes the rat renal brush-border membrane uptake of the beta-amino acid, taurine. A low-SAA diet enhances and a high-taurine diet reduces uptake (Chesney et al., Kidney Int. 24: 588-594, 1983). Neither the low-SAA diet nor the high-taurine diet alters the time course or concentration-dependent accumulation of the sulfur amino acids methionine and cystine or of inorganic sulfate. By contrast the uptake of beta-alanine, another beta-amino acid that competes with taurine, is greater in animals on the low-SAA diet. The high-taurine diet does not change beta-alanine uptake. The plasma levels of taurine are altered by dietary change, but not the values for methionine and cystine. This study indicates that renal adaptation is expressed for beta-alanine, a nonsulfur-containing beta-amino acid. By contrast, methionine, cystine, and sulfate, which participate in a variety of synthetic and conjugative processes, are not conserved by the renal brush-border surface following ingestion of either a low-methionine and -cystine diet or high-taurine diet.
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000603:Amino Acids, Sulfur / Q000378:metabolism*; D000818:Animals; D003553:Cystine / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000648:ultrastructure*; D007700:Kinetics; D008715:Methionine / Q000378:metabolism; D008871:Microvilli / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013431:Sulfates / Q000378:metabolism; D013654:Taurine / Q000378:metabolism; D013997:Time Factors; D015091:beta-Alanine / Q000378:metabolism
chemical_list: D000596:Amino Acids; D000603:Amino Acids, Sulfur; D004044:Dietary Proteins; D013431:Sulfates; D015091:beta-Alanine; D013654:Taurine; D003553:Cystine; D008715:Methionine