Effect of 2 episodes of cryosurgery on carcinogen-treated hamster cheek pouch.
Hamster cheek pouches were treated with the topical carcinogen DMBA for 8 weeks. 2 episodes of cryosurgery, located within the area of previous carcinogen application enhanced the neoplastic process by comparison with matched controls. Comparison with previous studies suggests that the 2 episodes of cryosurgery may have a greater effect in provoking overt malignancy than a single episode of cryosurgery.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002610:Cheek; D003043:Cocarcinogenesis; D006224:Cricetinae; D003452:Cryosurgery; D008297:Male; D008647:Mesocricetus; D009061:Mouth Mucosa / Q000187:drug effects* / Q000601:surgery; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000209:etiology*
D015127:9,10-Dimethyl-1,2-benzanthracene