title: Sleep apnea and autonomic cerebrovascular dysfunction.
abstract: Changes in common carotid blood flow (CCF) and resistance index (RI), calculated from velocity waveforms by a noninvasive pulsed Doppler technique, were measured during apneic episodes and voluntary breath holding in five sleep apnea patients (SA) and during breath holding in five normal subjects (N). During apneic episodes averaging 27 s, CCF was reduced by 9% and RI increased by 4%, both trends being related to apneic duration. Internal carotid artery measurements in one SA indicated more dramatic changes in blood flow and RI than noted in CCF. During breath holding, CCF decreased significantly in SA but not in N, and RI showed a smaller reduction in SA. These changes in CCF and RI during sleep apnea are similar to those noted in anesthetized dogs where vasomotor waves and associated apneas were induced by elevating intracranial pressure. Previously reported recordings of ventilatory and systemic cardiovascular responses in SA are similar to these recordings in dogs, and it is therefore proposed that vasomotor responses to intermittent cerebral ischemia and hypercapnia may be the principle event in SA and periodic breathing only a secondary consequence of the prevailing autonomic dysfunction.
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000502:physiology*; D002343:Carotid Artery, Internal / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D004285:Dogs; D006339:Heart Rate; D006801:Humans; D008875:Middle Aged; D012891:Sleep Apnea Syndromes / Q000503:physiopathology*; D014655:Vascular Resistance
chemical_list: D002245:Carbon Dioxide