Double-blind comparison of desipramine and placebo for treatment of phencyclidine or amphetamine dependence.
Open clinical trials have suggested that desipramine may be an effective agent for treatment of phencyclidine (PCP) or amphetamine dependence. Four pairs (eight subjects) with PCP and two pairs (four subjects) with amphetamine dependence were studied. One subject in each pair was given desipramine or placebo under double-blind conditions. Although desipramine clearly was no more effective than placebo in treatment of PCP dependence, subjects with amphetamine dependence who received desipramine remained in treatment longer and submitted more urine samples absent of amphetamine than did subjects who received placebo.
D000662:Amphetamines; D002986:Clinical Trials as Topic; D003891:Desipramine / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D010622:Phencyclidine / Q000652:urine; D010919:Placebos; D019966:Substance-Related Disorders / Q000534:rehabilitation*
D000662:Amphetamines; D010919:Placebos; D010622:Phencyclidine; D003891:Desipramine