[Enhancement of the antitumor effect on Walker-256 of administration of noradrenaline in physiological saline for five minutes after intraarterial injection of MMC].
An experimental study was performed on the enhancement of cytotoxic damage to a tumor by ischemia during chemotherapy. An antitumor effect was obtained by 10-minute ligation of the hindpaw of Wistar rats bearing implanted Walker-256 at four days before, and after administration of MMC into the same femoral artery. The injection of 0.5 microgram/ml of noradrenaline in physiological saline into the tumor-feeding artery at a rate of 1 ml/min for 5 minutes after intraarterial administration of MMC produced the same degree of improved antitumor effect as that observed in the 10-minute ligation therapy.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000098:blood supply / Q000188:drug therapy*; D007269:Injections, Intra-Arterial; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage* / Q000627:therapeutic use; D009638:Norepinephrine / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic
D008937:Mitomycins; D012462:Saline Solution, Hypertonic; D016685:Mitomycin; D009638:Norepinephrine