Brain temperature in the rat midbrain reticular formation is regulated by bombesin and TRH.
We investigated the effects of intraventricular (ivt) injection of bombesin on the TRH-induced increase in temperature in the midbrain reticular formation (mrf) of the rat brain under pentobarbital anesthesia. Ivt injection of TRH in a dose of 3 nmol significantly antagonized the decrease in brain temperature induced by pentobarbital, and this antagonistic action of TRH was dose-related. Ivt injection of 3-300 pmol bombesin produced a dose-related decrease in brain temperature in response to 3 nmol TRH injection. The present data provide evidence that bombesin and TRH produce opposite actions on thermoregulation of the mrf in the rat.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D001839:Bombesin / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000502:physiology*; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; D010424:Pentobarbital; D001839:Bombesin