title: Rodent IgE-binding factor genes are members of an endogenous, retrovirus-like gene family.
abstract: Synthesis of IgE by B lymphocytes can be regulated by soluble lymphocyte factors which have affinity for the Fc region of IgE (IgE-binding factors). In previous studies, we identified cDNA clones encoding rodent IgE-binding factors by direct expression in transfected mammalian cells. Here we show that IgE-binding factor cDNA clone 8.3 is a member of the endogenous, retrovirus-like intracisternal A-particle gene family of the mouse. This conclusion is supported by blot hybridization, DNA sequence comparisons, heteroduplex analysis, and immunochemical cross-reactivity of the encoded proteins. The results identify a member of this highly reiterated gene family with a role in regulation of the allergic immune response.
mesh_terms: D000042:Absorption; D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology; D003001:Cloning, Molecular; D004247:DNA / Q000378:metabolism; D005796:Genes; D007426:Genes, Intracisternal A-Particle; D005814:Genes, Viral; D008222:Lymphokines / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009693:Nucleic Acid Hybridization; D010455:Peptides / Q000276:immunology; D029584:Prostatic Secretory Proteins; D011519:Proto-Oncogenes; D051381:Rats; D011917:Rats, Inbred Lew; D012190:Retroviridae / Q000235:genetics*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D008222:Lymphokines; D010455:Peptides; D029584:Prostatic Secretory Proteins; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors; D004247:DNA