Interferon gamma regulates HLA-D expression on solid tumors in vivo.
In vivo administration of recombinant human interferon-gamma, rIFN-gamma, to nude mice bearing human tumor xenografts resulted in a strong induction of HLA-DR expression on the tumor cells in 2 of 3 lines tested. The induction was dose-dependent and declined rapidly after cessation of therapy. IFN-gamma also switched on DQ and DP products when the xenograft cells were treated in vitro. The in vivo alteration of tumor surface properties by rIFN-gamma may have therapeutic implications.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D005260:Female; D006681:HLA-D Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis / Q000276:immunology*; D007124:Immunoenzyme Techniques; D007371:Interferon-gamma / Q000494:pharmacology*; D051379:Mice; D009369:Neoplasms / Q000276:immunology
D000951:Antigens, Neoplasm; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D007371:Interferon-gamma