Radiation sensitization of Bacillus megaterium spores by trans-dichlorodiammineplatinum(II).
The radiation sensitivity of spores of Bacillus megaterium is markedly increased by transplatin in both N2 and O2, and in a manner suggesting the involvement of hydroxyl radicals in both instances, thus differing mechanistically from its isomer cisplatin.
D000332:Aerobiosis; D000693:Anaerobiosis; D001410:Bacillus megaterium / Q000187:drug effects / Q000528:radiation effects; D002945:Cisplatin / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013171:Spores, Bacterial / Q000187:drug effects / Q000528:radiation effects
D011838:Radiation-Sensitizing Agents; C034697:transplatin; D002945:Cisplatin