[Effect of bacterial toxins on microcirculation (experimental research)].
Histological and biomicroscopic methods were used to study the effects of toxic lemic and meningococcal microbial fractions on mesenteric blood microcirculation in rats. Aggregation ability of red blood cells and thrombocytes was investigated. The sublethal dose of meningococcal toxins was shown to induce marked impairment in the blood microcirculation 30 minutes after intravenous administration. The lethal dose of lemic toxins manifests itself later (in 2-4 hours). Meningococcal toxins are characterized by the increase in the aggregation ability of erythrocytes and thrombocytes in initial observation periods; lemic toxins increase the thrombocyte aggregation and produce almost no effect on erythrocyte aggregation.
D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004903:Erythrocyte Aggregation / Q000187:drug effects; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000473:pathology; D009345:Neisseria meningitidis; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D013152:Splanchnic Circulation / Q000187:drug effects*; D013997:Time Factors; D015010:Yersinia pestis
D001427:Bacterial Toxins
Vliianie bakterial'nykh toksinov na mikrogemotsirkuliatsiiu (éksperimental'noe issledovanie).