Effect of Ro 23-6240 on sensitive and resistant intracellular mycobacteria.
The activity of Ro 23-6240 and rifampicin against intracellular Mycobacterium fortuitum and Mycobacterium chelonei was assessed in vitro over a 48-hour period. Both agents, at an extracellular concentration of 2.0 mg/l (Ro 23-6240) and 1.0 mg/l (rifampicin), produced a significant intracellular killing of the sensitive Mycobacterium fortuitum at both 20 and 48 hours. However, neither agent was effective against the resistant Mycobacterium chelonei. It was concluded that Ro 23-6240 has a direct antimicrobial effect against sensitive intracellular mycobacteria.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D016576:Fleroxacin; D006801:Humans; D008264:Macrophages / Q000382:microbiology; D051379:Mice; D009161:Mycobacterium / Q000187:drug effects*; D009170:Nontuberculous Mycobacteria / Q000187:drug effects*; D012293:Rifampin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D016576:Fleroxacin; D012293:Rifampin