Effect of ovariectomy on response to dietary cholesterol in patas monkeys (Erythrocebus patas).
From a group of 20 patas monkeys (Erythrocebus patas), four high and four low responders to dietary cholesterol were selected for this study. The monkeys were paired according to their responsiveness to cholesterol, and ovariectomies were carried out on one group of the matched pairs. For the study, the monkeys were fed a Prudent Diet (at 0.1 mg cholesterol/cal) for 5 months preceding the ovariectomy and for 7 months after the ovariectomy followed by a Rich Diet (at 0.4 mg cholesterol/cal) for 7 months. Serum cholesterol, apo B, and apo A-I concentrations and cholesterol distributions were determined. We observed that while the monkeys consumed the Prudent Diet, total serum cholesterol. HDL cholesterol, and apo A-I increased in the ovariectomized group, but not in the control group. When they began consuming the Rich Diet, total serum cholesterol, apo B, and apo A-I concentrations increased in all monkeys, but increased more in the ovariectomized monkeys. The effect of the loss of ovarian function on lipoprotein metabolism is accentuated when the monkeys are fed a Rich Diet designed to be similar to a saturated fat, cholesterol-rich diet consumed by human beings.
D000818:Animals; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D002499:Centrifugation, Density Gradient; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D008076:Cholesterol, HDL / Q000097:blood; D004901:Erythrocebus patas; D005260:Female; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000032:analysis / Q000097:blood; D008077:Lipoproteins, LDL / Q000032:analysis / Q000097:blood; D010052:Ovariectomy; D010053:Ovary / Q000378:metabolism*
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D002784:Cholesterol