A quantitative study of the effect of terfenadine on cutaneous erythema induced by UVB and UVC radiation.
Terfenadine, given in sufficient dose to cause maximum H1 receptor blockade, had no effect on the intensity of UVB or UVC erythema measured with a reflectance instrument at 4, 8, and 24 h after irradiation. Histamine, acting on the H1 receptor, is not a significant mediator of UVB or UVC erythema.
D000328:Adult; D000818:Animals; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D004307:Dose-Response Relationship, Radiation; D004890:Erythema / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D008297:Male; D011833:Radiation Injuries, Experimental; D016593:Terfenadine; D014466:Ultraviolet Rays
D001559:Benzhydryl Compounds; D016593:Terfenadine; D006632:Histamine