Effects of hyperinsulinism and of diabetes on proteoglycans of the intervertebral disc in weanling sand rats.
Weanling sand rats (Psammomys obesus) develop hyperinsulinemia or diabetes or both, if fed a standard laboratory diet without a supplement of fiber rich salt bush. The annuli fibrosi of hyperinsulinemic or diabetic animals, which are still hyperinsulinemic, show a slight but statistically significant increase in chondroitin sulfate and a lesser, statistically nonsignificant increase in keratan sulfate. Possible causes of these changes are discussed and the likelihood of a role of hyperinsulinism in their production is pointed out.
D000821:Animal Feed; D000818:Animals; D003411:Arvicolinae; D002809:Chondroitin Sulfates / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004032:Diet; D006946:Hyperinsulinism / Q000178:diet therapy / Q000503:physiopathology*; D007403:Intervertebral Disc / Q000378:metabolism / Q000473:pathology*; D007632:Keratan Sulfate / Q000378:metabolism; D010945:Plants, Edible; D011509:Proteoglycans / Q000378:metabolism*; D013053:Spectrophotometry; D014886:Weaning
D011509:Proteoglycans; D002809:Chondroitin Sulfates; D007632:Keratan Sulfate