title: [Role of thyroxine in releasing tissue plasminogen activators].
abstract: Experiments on animals have shown that thyroxin at doses of 10, 50 and 150 micrograms/kg promotes releasing the plasminogen tissue activator from the kidneys, liver and heart. It leads to an increase in the difference in its content in the venous and arterial blood of these organs as compared to control animals. Thyroxin at the above doses simultaneously decreases the level of the plasminogen activator in the pulmonary, renal and liver tissue as well as in the myocardium.
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D008102:Liver Circulation / Q000187:drug effects; D008297:Male; D011652:Pulmonary Circulation / Q000187:drug effects; D011817:Rabbits; D012079:Renal Circulation / Q000187:drug effects; D013974:Thyroxine / Q000494:pharmacology*; D013997:Time Factors; D014018:Tissue Distribution; D010959:Tissue Plasminogen Activator / Q000097:blood / Q000378:metabolism*
chemical_list: D010959:Tissue Plasminogen Activator; D013974:Thyroxine
vernacular_title: Rol' tiroksina v osvobozhdenii tkanevykh aktivatorov plazminogena.