111In-tropolonate labelled platelets; studies in normals and in patients with thrombocytopenia.
Human platelets were labelled with aqueous 111In-tropolonate in comparison with 111In-oxinate. In normals the labelling efficiency with 111In-tropolonate was higher (93% +/- 2%) than with 111In-oxinate (67% +/- 8%) (P less than 0.05). In cases of severe thrombocytopenia, lower labelling efficiencies were obtained. In six normals a mean platelet life of 9 days +/- 3 days and an initial recovery of 59% +/- 15% were obtained. In twelve patients with thrombocytopenia the mean platelet life was 4 days +/- 4 days and the initial recovery was 58% +/- 20%. The absolute uptake of radioactivity in spleen and in liver in both groups are reported.
D001792:Blood Platelets / Q000503:physiopathology; D002470:Cell Survival; D005260:Female; D006801:Humans; D007204:Indium; D007553:Isotope Labeling; D008099:Liver / Q000000981:diagnostic imaging; D008297:Male; D009942:Organometallic Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging; D013921:Thrombocytopenia / Q000000981:diagnostic imaging*; D013997:Time Factors; D014334:Tropolone / Q000031:analogs & derivatives
D009942:Organometallic Compounds; D011868:Radioisotopes; D007204:Indium; C043895:indium tris(tropolonate); C032950:indium oxine; D015125:Oxyquinoline; D014334:Tropolone