[Transdermal nitroglycerin in the treatment of pulmonary hypertension].
In 10 patients with pulmonary hypertension, glycerol trinitrate in patch form (DEPONIT 10) effected a statistically significant drop in pulmonary artery pressure, pulmonary capillary pressure and right atrial pressure within 24 hours following drug application. This pressure reduction was also recorded after 4 weeks of continuous therapy. The reduction of pulmonary artery pressure and pulmonary vascular resistance is not only a consequence of improved pre- and afterload, but also of a decrease in respiratory tract resistance and a direct influence on arteriolar constriction in the pulmonary vascular bed. Beneficial effects upon pulmonary haemodynamics were also recorded several months later.
D000279:Administration, Cutaneous; D001794:Blood Pressure / Q000187:drug effects; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage*; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
D003692:Delayed-Action Preparations; D005996:Nitroglycerin
Transdermales Nitroglyzerin in der Behandlung der pulmonalen Hypertonie.