[Serum and tissue concentrations of UFT in patients with lung cancer].
Postoperative serum and tissue concentrations of 5-FU, FT-207 and uracil were measured in 36 patients with lung cancer who were administered UFT for seven days preoperatively. The concentration of 5-FU was high in tumor tissue and lymph nodes, but very low in serum. Such differences were not observed in the FT-207 levels. Tumor concentration of 5-FU in patients administered daily doses of 600 mg was 0.151 +/- 0.099 microgram/g which was three times higher than the minimum inhibitory concentration, and higher than that seen with other doses. The histological type and T factor were not related to the tissue concentration of 5-FU. Lymph node metastasis was not related to the concentration of 5-FU in the lymph nodes. The optimal daily dose of UFT for patients with lung cancer was considered to be 600 mg.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000378:metabolism* / Q000627:therapeutic use; D005472:Fluorouracil / Q000032:analysis; D006801:Humans; D008168:Lung / Q000032:analysis; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D008198:Lymph Nodes / Q000378:metabolism; D008207:Lymphatic Metastasis; D005641:Tegafur / Q000032:analysis / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D014498:Uracil / Q000032:analysis / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use
D005641:Tegafur; D014498:Uracil; D005472:Fluorouracil