title: [Modification of psychophysical performance of the human by anticonvulsants].
abstract: Antiepileptics can impair the performance of subjects in both acute and subacute doses. The effects of phenobarbital and its derivatives and benzodiazepines are stronger in this respect than that of phenytoin, ethosuccimides and valproic acid. Carbamazepine, in contrast, has rather a stimulatory action. Impaired cognition, psychomotor performance and emotions must also be expected under therapeutic conditions. Attention is drawn to various factors that may influence the results of tests, including the dose and blood concentration, interval between application and test, initial performance of the probands or patients, levels of vigilance and personality structure. Lack of compliance is particularly important since adaptation and readaptation processes that can be dangerous take place in these patients. The careful exploration of side-effects on the patient may have a decisive influence on practicability and cost if the relationship between patient and doctor is good.
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001143:Arousal / Q000187:drug effects; D002220:Carbamazepine / Q000009:adverse effects; D003975:Diazepam / Q000009:adverse effects; D004827:Epilepsy / Q000188:drug therapy*; D005013:Ethosuximide / Q000009:adverse effects; D006801:Humans; D008606:Mental Processes / Q000187:drug effects*; D010634:Phenobarbital / Q000009:adverse effects; D011581:Psychological Tests; D011597:Psychomotor Performance / Q000187:drug effects; D014635:Valproic Acid / Q000009:adverse effects
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D005013:Ethosuximide; D014635:Valproic Acid; D003975:Diazepam; D010634:Phenobarbital
vernacular_title: Zur Beeinflussung der psychophysischen Leistungsfähigkeit des Menschen durch Antiepileptika.