[The influence and effectiveness of hydrochloric acid infusion on the extra- and intracellular acid-base status in vivo. Experimental study on rat tissue].
The influence of HCl infusion on extra- and intracellular acid-base status of liver, brain, heart, and skeletal muscle of nephrectomized rats was investigated in vivo. The present results showed that a decrease of extracellular plasma pH was followed by similar changes of the intracellular pH of the investigated tissues and a loss of bicarbonate from extracellular and intracellular body compartment. The results lead to the conclusion that HCl seems to be a suitable agent for correction of severe metabolic alkalosis.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001923:Brain Chemistry / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D006851:Hydrochloric Acid / Q000494:pharmacology*; D007263:Infusions, Parenteral; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001639:Bicarbonates; D002245:Carbon Dioxide; D006851:Hydrochloric Acid
Einfluss und Effektivität von Salzsäureinfusion auf den extra- und intrazellulären Säuren-Basen-Status in vivo. Experimentelle Untersuchungen an Rattengeweben.