Metabolism of viprostol--a synthetic vasodilator PGE2 analog.
Metabolic studies were done with 14C-Viprostol (I) administered by various routes (I.V., oral and topical) to six animal species and to man. Total radioactivity and metabolic profiles were analyzed in plasma, tissues and excreta. The main metabolites were isolated and identified by capillary GC/MS. Plasma and urinary metabolic profiles were qualitatively similar across species, with two major metabolic reactions being predominant: rapid hydrolysis to the pharmacologically active free acid (II) and oxidation of the alpha-chain to dinor and tetranor acids (III, IV). In the monkey and man, reduction of the 9-keto group lead to PGF2 type metabolites (VI-VIII). In the rat, omega oxidation of the beta-chain occurred as well, resulting in the formation of dicarboxylic acids (V).
D000287:Administration, Topical; D000818:Animals; D015232:Dinoprostone / Q000031:analogs & derivatives; D004285:Dogs; D006168:Guinea Pigs; D000882:Haplorhini; D006801:Humans; D008657:Metabolic Clearance Rate; D051379:Mice; D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000378:metabolism; D014665:Vasodilator Agents / Q000378:metabolism*
D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; D014665:Vasodilator Agents; D015232:Dinoprostone; C034232:viprostol