Ahpatinins, new acid protease inhibitors containing 4-amino-3-hydroxy-5-phenylpentanoic acid.
A soil isolate, Streptomyces sp. WK-142, was found to produce new acid protease inhibitors, ahpatinins A, B, D, E, F and G active against pepsin and renin. Ahpatinin C was found to be identical with pepstatin A. The structure determinations were based on mass spectral data. Four of the compounds contain the unusual amino acid, 4-amino-3-hydroxy-5-phenylpentanoic acid as a building component.
D000596:Amino Acids / Q000032:analysis*; D016282:Aspartic Acid Endopeptidases; D055598:Chemical Phenomena; D002621:Chemistry; D010450:Endopeptidases; D013058:Mass Spectrometry; D009842:Oligopeptides / Q000302:isolation & purification*; D010434:Pepsin A / Q000037:antagonists & inhibitors; D010436:Pepstatins / Q000302:isolation & purification* / Q000494:pharmacology; D011480:Protease Inhibitors; D013302:Streptomyces / Q000145:classification / Q000378:metabolism; D000092502:Renin Inhibitors
D000596:Amino Acids; D016282:Aspartic Acid Endopeptidases; D010450:Endopeptidases; D009842:Oligopeptides; D010434:Pepsin A; D010436:Pepstatins; D011480:Protease Inhibitors; D000092502:Renin Inhibitors; C049986:4-amino-3-hydroxy-5-phenylpentanoic acid