Growth inhibition of Trypanosoma cruzi in cultured murine myocardial cells mediated by a specifically induced lymphokine.
An in vitro model for studying the protection of mouse myocardial cells against Trypanosoma cruzi was developed. It was demonstrated that immune mouse lymphocytes stimulated with a specific antigen elicited a mediator which protected myocardial cells from newborn mice against T. cruzi infection. The substance responsible for this activity was sensitive to acid (pH 2) treatment.
D000818:Animals; D002478:Cells, Cultured; D014355:Chagas Disease / Q000276:immunology*; D008222:Lymphokines / Q000494:pharmacology*; D051379:Mice; D008809:Mice, Inbred C3H; D009206:Myocardium / Q000166:cytology; D014349:Trypanosoma cruzi / Q000187:drug effects*
D008222:Lymphokines