[Induction of remissions of insulin-dependent diabetes by cyclosporin].
The effect of cyclosporine was evaluated in a double blind placebo controlled trial in 122 recent onset insulin-dependent diabetics. A significantly higher incidence of complete remissions was observed in patients treated with cyclosporine than in those receiving placebo (respectively 24 and 5.8%). The effect was still more clear-cut in patients having presented the highest cyclosporine blood level (37%). These results which have been obtained with modest toxicity demonstrate that cyclosporine induces remission of insulin-dependent diabetes and prompt to set up new controlled trials to evaluate the duration of the effect obtained and the potential risks of the treatment.
D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D003524:Cyclosporins / Q000097:blood / Q000627:therapeutic use*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000276:immunology; D004311:Double-Blind Method; D006801:Humans; D007167:Immunotherapy; D010919:Placebos; D012074:Remission Induction
D003524:Cyclosporins; D010919:Placebos
Induction de rémissions du diabète insulino-dépendant par la cyclosporine.