In vitro immune interferon induction during tumor evolution.
In a syngeneic C3H mammary adenocarcinoma model we studied gamma-interferon (gamma IFN) production during tumor evolution. The IFN production was induced by soluble tumor extracts on spleen cell cultures from tumor-bearing mice. A low level of IFN production was found in culture supernatants from small tumor-bearing mice (tumor diameter less than 10 mm, 12-15 days of tumor evolution). In advanced stages of tumor growth (diameter more than 15 mm, 20 days or more of tumor evolution), this ability was lost.
D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology; D000818:Animals; D002478:Cells, Cultured; D006863:Hydrogen-Ion Concentration; D007108:Immune Tolerance; D007371:Interferon-gamma / Q000096:biosynthesis*; D008325:Mammary Neoplasms, Experimental / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D013154:Spleen / Q000166:cytology
D007371:Interferon-gamma