Microbial structures in a patient with sporadic non-A, non-B fulminant hepatitis treated by liver transplantation.
Double-shelled virus-like particles (60 nm) and long cytoplasmic tubular structures were found in the cytoplasm of hepatocytes from areas of collapsed and regenerating areas of hepatectomised liver in a 13-year-old boy who received a liver graft for fulminant hepatitis attributed to sporadic non-A, non-B hepatitis. The patient died on the ninth postoperative day from acute graft failure. Although virus-like particles were not found, instead, gram-negative rods were identified in the necrotic graft and the most likely cause of death was a gram-negative septicaemia with a Shwartzman-like reaction localized to the liver.
D000293:Adolescent; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006498:Hepatectomy; D006526:Hepatitis C / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D006525:Hepatitis, Viral, Human / Q000382:microbiology*; D006801:Humans; D008099:Liver / Q000382:microbiology* / Q000648:ultrastructure; D016031:Liver Transplantation; D008297:Male; D008854:Microscopy, Electron; D012790:Shwartzman Phenomenon; D014780:Viruses / Q000648:ultrastructure*