Functional anemia of complicated protein-energy malnutrition at high altitude.
The effect of severe protein-energy malnutrition (PEM) on erythropoiesis in children living in the highlands of Bolivia, altitude 3700 m, was studied. Forty percent reduced hemoglobin concentrations, significantly lower arterial oxygen tensions, and a right-shifted, oxygen-dissociation curve were observed compared to high-altitude controls. Serum and erythrocyte folate concentrations were 44% and 82%, respectively, of control values. Low initial transferrin saturation decreased significantly during the 10-wk refeeding period. Thus, iron and folate deficiency contributed significantly to the poor red cell response. Results suggest that the anemia associated with severe PEM has a more significant impact on oxygen transport at high altitude than at sea level and requires an adaptive response in the oxygen-dissociation curve to satisfy tissue-oxygen demands. Furthermore, marginal iron and folate status and an inflammatory block of iron supply may limit the reestablishment of a normal tissue mass during refeeding.
D000531:Altitude; D000747:Anemia, Hypochromic / Q000178:diet therapy / Q000209:etiology*; D000886:Anthropometry; D002648:Child; D002675:Child, Preschool; D004032:Diet; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D010100:Oxygen / Q000378:metabolism; D011502:Protein-Energy Malnutrition / Q000150:complications* / Q000178:diet therapy / Q000503:physiopathology
D010100:Oxygen