Effect of a single oral dose of enprostil on gastric secretion and gastrin release. Studies in healthy volunteers and patients with pernicious anemia.
In healthy human volunteers, a single oral dose of enprostil (35 micrograms) inhibited basal gastric acid output by a mean of 71 percent, pentagastrin-stimulated output by 46 percent, sham-meal-stimulated output by 48 percent, and histamine-stimulated output by 16 percent. In each case, there was a reduction in both the volume and acidity of the gastric juice. Pepsin output was unchanged. Although enprostil increased the gastric pH, it did not induce basal or post-prandial hypergastrinemia. In patients with hypergastrinemia secondary to achlorhydria, enprostil lowered the basal gastrin level and reduced or abolished the post-prandial gastrin rise in a dose-related fashion. Enprostil reduces basal and stimulated gastric acid secretion and inhibits gastrin release.
D000126:Achlorhydria / Q000097:blood / Q000503:physiopathology; D000328:Adult; D000752:Anemia, Pernicious / Q000097:blood / Q000503:physiopathology*; D016620:Enprostil; D005744:Gastric Acid / Q000378:metabolism*; D005750:Gastric Juice / Q000378:metabolism; D005755:Gastrins / Q000097:blood*; D006632:Histamine; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D010418:Pentagastrin; D010434:Pepsin A / Q000378:metabolism; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*
D005755:Gastrins; D011459:Prostaglandins E, Synthetic; D006632:Histamine; D010434:Pepsin A; D010418:Pentagastrin; D016620:Enprostil