Bacillus cereus endophthalmitis.
The authors present a case of a young man with post-traumatic endophthalmitis caused by Bacillus cereus. The clinical course was typical of the panophthalmitis caused by this toxin-producing organism: rapid onset of signs of systemic infection, a corneal ring abscess and eventual loss of the globe requiring enucleation. Studies of experimental rabbit models of the infection have indicated that the most efficacious regimen consists of systemic and topical clindamycin and gentamicin. Successful therapy depends upon immediate systemic administration of these agents when the clinical setting suggests Bacillus cereus infection.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001409:Bacillus cereus; D001424:Bacterial Infections / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D002981:Clindamycin / Q000627:therapeutic use; D009877:Endophthalmitis / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D005131:Eye Injuries / Q000150:complications*; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D008297:Male; D013508:Ophthalmologic Surgical Procedures; D011379:Prognosis; D014950:Wounds, Penetrating / Q000150:complications*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002981:Clindamycin