Antitumor activity of protein-bound polysaccharide from Cordyceps ophioglossoides in mice.
The effects of protein-bound polysaccharide (SN-C) extracted from Cordyceps ophioglossoides on the growth of transplanted allogeneic and syngeneic murine tumors were studied. SN-C given by intraperitoneal administration suppressed the growth of sarcoma-180 transplanted subcutaneously in mice. Intraperitoneal administration of SN-C also caused a significant prolongation of the life span of ICR mice inoculated intraperitoneally with Ehrlich carcinoma, and C3H/He mice inoculated intraperitoneally with a syngeneic tumor (X-5563). SN-C showed a significant cytocidal effect on cultured tumor cells. SN-C did not affect delayed-type hypersensitivity (DTH) in normal mice, but restored the depressed capacity to raise DTH in tumor-bearing mice. These results suggested that SN-C may exert both direct and host-mediated antitumor effects.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D005260:Female; D006968:Hypersensitivity, Delayed; D006999:Hypocreales / Q000737:chemistry*; D051379:Mice; D008809:Mice, Inbred C3H; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000276:immunology; D011509:Proteoglycans / Q000302:isolation & purification / Q000494:pharmacology; D012510:Sarcoma 180 / Q000188:drug therapy
D000903:Antibiotics, Antineoplastic; D011509:Proteoglycans; C051547:protein-bound SN-C polysaccharide