A case of liver cirrhosis complicated with endotoxemia and disseminated intravascular coagulation: a case report.
A 59-year-old female was admitted to our hospital because of massive ascites and increasing jaundice, suggesting a severe decompensated state of liver cirrhosis. On the third hospital day, she was diagnosed as disseminated intravascular coagulation (DIC) from a coagulofibrinolytic study and developed renal failure. Continuous drip infusion of gabexate mesilate, a synthetic inhibitor of serine-protease, was found to be successful in managing DIC, followed by the restoration of renal function. During the clinical course, blood endotoxin, assayed by the chromogenic method, was initially 11 pg/ml and increased, in accordance with the elevation of serum FDP, to a level of 110 pg/ml when renal failure occurred. A proportional relationship was observed between changes in blood endotoxin and serum FDP throughout the course. This finding may be an important clue in studying the mechanism of DIC and non-septic endotoxemia both developing in liver cirrhosis.
D004211:Disseminated Intravascular Coagulation / Q000150:complications* / Q000188:drug therapy; D004731:Endotoxins / Q000097:blood*; D005260:Female; D016670:Gabexate; D006146:Guanidines / Q000627:therapeutic use; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008875:Middle Aged
D004731:Endotoxins; D006146:Guanidines; D016670:Gabexate