Formation of calcium oxalate urolithiasis in experiment and its inhibition by pyridoxine and magnesium.
Possibility of application of experimental model of calcium oxalate urolithiasis to the study of some medicament actions useful in prevention of calcium oxalate urolithiasis in men has been examined in animal experiments. Inhibition effects of pyridoxine and magnesium in formation of calcium oxalate stone formation have been proved. Administration of pyridoxine and/or magnesium to experimental animals inhibited formation of incrustations on renal papillae. Administration of nothing but magnesium lowered considerably also frequency of nephrocalcinosis occurrence. Good reproducibility of applied model of calcium oxalate urolithiasis creates conditions for further experimental study of this kind of urolithiasis. In the previous series of experiments (4) we tiped out an experimental model of calcium oxalate urolithiasis in animals well reproducible in our conditions. In the following period we were interested, whether the created model can be applied to verification of efficiency and further study of some medicaments affecting this kind of urolithiasis. At present, pyridoxine and magnesium are mode widely used for prevention of calcium oxalate urolithiasis in the clinical practice. Therefore, we decided to use the possibilities of the evaluated experimental model for the study of their inhibition effects. The results of experiments are presented in this paper.
D000818:Animals; D002129:Calcium Oxalate / Q000378:metabolism*; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D011736:Pyridoxine / Q000494:pharmacology*; D051381:Rats; D014545:Urinary Calculi / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*
D002129:Calcium Oxalate; D008274:Magnesium; D011736:Pyridoxine