[Food allergies. III. Therapy: elimination diet, symptomatic drug prophylaxis and specific hyposensitization].
The treatment of food allergies is logically based on strict elimination of causative allergens. While it is easy to eliminate food which is infrequently consumed, it is more difficult to manage an allergy involving regularly consumed foods, especially where patients have to eat away from home for professional reasons. The creation of elimination diets for milk, eggs, and mould and yeast allergies is discussed. In raw food and vegetable allergy the act of cooking is often sufficient to denature the allergen as it is unstable to heat. Follow-up investigations show that some 50% of children achieve cure spontaneously by strict elimination diet, especially in regard to milk allergy. In our own 173 (mainly adult) patients with food allergy, some 2/3 reported after 3-5 years that a strict elimination diet had to be followed, since otherwise prompt relapse of allergic symptoms was noted. About 1/3 of patients, mainly with milk, cheese or egg allergy, can hope for spontaneous desensitization by appropriate diet. This is demonstrated by a case history with disappearance of IgE antibodies. Should this fail to occur, oral desensitization with milk or egg-white extracts offers an effective therapy. The practice of hyposensitization with foodstuffs is illustrated by examples and tabulation of immunologic parameters. In raw food or vegetable allergy, which is often associated with birch or mugwort pollinosis, improvement or even complete cure can be expected in about 1/3 of cases by systematic desensitization of pollinosis. On the other hand, the therapy and prognosis of food allergy involving extreme and polyvalent sensitivities, especially to spices, or with multifactorially induced symptoms, is more problematic. In these cases a strict elimination diet should be followed by continuous prophylactic/symptomatic treatment with antianaphylactic substances such as cromoglicinic acid (Nalcrom) - especially in gastrointestinal food allergies - or with ketotifen (Zaditen) or oxatomide (Tinset) in hematogenically released shock fragments. Patients with severe anaphylactic reactions after meals should, by analogy with patients with hymenoptera allergy, carry an emergency kit containing an adrenaline spray (Medihaler-Epi), a soluble corticosteroid (e.g. Betnesol) and anthistaminic drugs (e.g. Tavegyl, Teldane).
D000328:Adult; D000707:Anaphylaxis / Q000517:prevention & control; D000818:Animals; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003296:Cooking; D004205:Cromolyn Sodium / Q000627:therapeutic use; D003888:Desensitization, Immunologic; D004032:Diet; D005260:Female; D005512:Food Hypersensitivity / Q000178:diet therapy / Q000628:therapy*; D006801:Humans; D007223:Infant; D008892:Milk / Q000009:adverse effects
D004205:Cromolyn Sodium
Nahrungsmittelallergien. III. Therapie: Eliminationsdiät, symptomatische medikamentöse Prophylaxe und spezifische Hyposensibilisierung.