title: Overview of the present state of MAO inhibitors.
abstract: In this paper an overview of the present state of monoamine oxidase inhibitors (MAOIs) is presented. The irreversible inhibitors are firstly considered. They have been divided into four chemical types: substituted hydrazine, cyclopropylamine, propargylamine and allylamine derivatives. Moreover, a tetrahydropyridine derivative (MPTP), recently described as an irreversible inhibitor of MAO-B, has been included among the irreversible MAOIs. The reversible inhibitors such as tetrahydro-beta-carbolines and salsolinol, phenylalkylamines: amphetamine, amiflamine and 2,3-dichloro-alpha-methyl-benzylamine. Among the short acting or reversible inhibitors the 4-(2-benzofuranyl) piperidine series and the morpholinoethylamino derivatives are discussed. Finally the oxazolidinone series is presented separately, as in this series reversible or irreversible inhibitors of the A or B form of MAO have been obtained.
mesh_terms: D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology; D007546:Isoquinolines / Q000494:pharmacology; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D010080:Oxazoles / Q000494:pharmacology; D023303:Oxazolidinones; D010300:Parkinson Disease / Q000188:drug therapy; D010627:Phenethylamines / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D012642:Selegiline / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D001549:Benzamides; D006834:Hydrazines; D007546:Isoquinolines; D008996:Monoamine Oxidase Inhibitors; D010080:Oxazoles; D023303:Oxazolidinones; D010627:Phenethylamines; D010880:Piperidines; D012642:Selegiline; C010798:toloxatone; C038213:brofaromine; C051040:Ro 16-6491; C036617:salsolinol