[Effect of exogenous gangliosides on the metabolism of inositol compounds in chick neurons in primary culture].
A mixture of exogenous gangliosides at 10(-8) M and 10(-5) M concentration added to the medium of chick neurons stimulates the metabolism of inositol compounds. Notably the incorporation of [3H] myo-inositol is increased in phosphatidylinositol and in inositol triphosphate. Gangliosides, hence, by increasing the production of second messengers might regulate the phosphorylation processes of neuronal proteins.
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D005732:Gangliosides / Q000494:pharmacology*; D007294:Inositol / Q000378:metabolism*; D007295:Inositol Phosphates / Q000096:biosynthesis; D007700:Kinetics; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D005732:Gangliosides; D007295:Inositol Phosphates; D007294:Inositol
Effet de gangliosides exogènes sur le métabolisme des composés à inositol dans les neurones de poulet en culture primaire.