Mitomycin C induced chromosomal aberrations and sister chromatid exchanges (SCEs) in lymphocytes of patients with precancerous and cancerous lesions of the uterine cervix.
Baseline and mitomycin C (MMC)-induced chromosomal aberrations and sister chromatid exchanges (SCEs) in blood lymphocytes of patients with cervical precancerous and cancerous lesions and normal women were studied. The baseline frequency of chromosomal aberrations and SCEs revealed a significant increase in higher grades of precancerous (moderate and severe dysplasias) and cancerous lesions compared to those of controls. The MMC-induced chromosomal aberrations and SCEs did not show any differential response in the different groups studied. The results thus indicate that chromosomal instability as observed in precancerous and cancerous lesions is not associated with their sensitivity to mitomycin C.
D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D016685:Mitomycin; D008937:Mitomycins / Q000009:adverse effects*; D011230:Precancerous Conditions / Q000235:genetics*; D012854:Sister Chromatid Exchange; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000235:genetics
D008937:Mitomycins; D016685:Mitomycin