Histamine levels and activity of histidine decarboxylase (HD) and histamine-methyltransferase (HMT) in neonate and adult human brain.
The adult human brain contained histamine (HI), and showed well-expressed histidine decarboxylase (HD), histamine-methyltransferase (HMT) and monoamine oxidase (MAO) activity. The neonate human brain contained HI, and showed HMT and MAO activity; there was no HD activity. Neither the adult nor neonate brains possessed diamine oxidase activity.
D000328:Adult; D000367:Age Factors; D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D001923:Brain Chemistry; D002262:Carboxy-Lyases / Q000378:metabolism*; D006632:Histamine / Q000032:analysis*; D006637:Histamine N-Methyltransferase / Q000378:metabolism*; D006640:Histidine Decarboxylase / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D008780:Methyltransferases / Q000378:metabolism*; D008995:Monoamine Oxidase / Q000378:metabolism
D006632:Histamine; D006631:Amine Oxidase (Copper-Containing); D008995:Monoamine Oxidase; D008780:Methyltransferases; D006637:Histamine N-Methyltransferase; D002262:Carboxy-Lyases; D006640:Histidine Decarboxylase