title: Immunoglobulin (Gm and Km) allotypes in nine endogamous groups of West Bengal, India.
abstract: Blood samples from 898 individuals of nine endogamous groups of West Bengal, India were typed for determining the haplotypic structure in the gamma-light chain (Gm) and kappa-light chain (Km) of immunoglobulin (IgG). The Gm haplotype frequencies detected by Glm (1), Glm (2) and G3m (5) markers suggest that in this eastern state of India there is considerable variation of frequencies of the typical Mongoloid haplotype Gm1,5, which shows a high incidence in Rajbanshi, Rabha, Garo and Lodha groups. On the contrary, this haplotype is probably absent in the high caste groups, Rarhi Brahmin and Vaidya, and is relatively infrequent in Jalia Kaibarta, a scheduled caste of the south-western part of the state. The Km1 allele is also high in frequency among Rajbanshi, Rabha, Garo and Munda in comparison with Rarhi Brahmin and Vaidya, suggesting the former four groups' strong Mongoloid affiliation. This survey signifies that there is considerable variation in the extent of Mongoloid admixture in Bengali populations. Such admixture is not restricted in specific social class either. It further demonstrates that heterogeneity of the genetic structure of Bengali populations do not correspond to the present social ranking on the basis of caste hierarchy.
mesh_terms: D044466:Asian People; D003241:Consanguinity; D005828:Genetics, Population; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000032:analysis*; D007129:Immunoglobulin Gm Allotypes / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007194:India; D044465:White People
chemical_list: D007126:Immunoglobulin Allotypes; D007129:Immunoglobulin Gm Allotypes; D007145:Immunoglobulin kappa-Chains