Plipastatins: new inhibitors of phospholipase A2, produced by Bacillus cereus BMG302-fF67. III. Structural elucidation of plipastatins.
Plipastatins are new inhibitors of phospholipase A2 produced by Bacillus cereus BMG302-fF67. Structures of the plipastatins have been determined by UV, mass and NMR spectrometries and chemical degradation. The carboxyl group of the C-terminal L-isoleucine of plipastatinic acid has been shown to form a lactone linkage with the hydroxyl group of L-tyrosine. The total structure of plipastatins has thus been established.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000494:pharmacology; D001409:Bacillus cereus / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D005227:Fatty Acids / Q000032:analysis*; D007783:Lactones; D009682:Magnetic Resonance Spectroscopy; D009842:Oligopeptides / Q000032:analysis*; D010456:Peptides, Cyclic; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D007783:Lactones; D009842:Oligopeptides; D010456:Peptides, Cyclic; C049901:plipastatin; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2