[Inhibition by melanin of lipid photo-oxidation].
Removal of melanosomes from retinal pigment epithelium cells is accompanied by a sharp rise in the rate of VIS light-induced lipid peroxidation. The synthetic DOPA-melanin effectively suppresses the UV light-induced lipid peroxidation of cardiolipin not only through a passive decrease of irradiation (optical screening), but also by active chemical inhibition of the reaction. It is assumed that the observed active inhibition is due to the interaction between DOPA-melanin and the free radical products generated in cardiolipin upon UV illumination. It is concluded that the high photoresistance of melanin-containing cells of retinal pigment epithelium is due to the ability of melanosomes to exert strong inhibition of photo-induced lipid peroxidation.
D000818:Animals; D003864:Depression, Chemical; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008544:Melanocytes / Q000378:metabolism; D010084:Oxidation-Reduction; D010777:Photochemistry; D010857:Pigment Epithelium of Eye / Q000378:metabolism*; D011896:Rana temporaria
D004295:Dihydroxyphenylalanine; C040616:DOPA melanin
Ingibirovanie melaninom protsessa fotookisleniia lipidov.