[Hypotensive, antianginal action and pharmacokinetics of glyceryl-1-nitrate in rats and dogs].
The antianginal and hypotensive activity and the pharmacokinetic properties of glyceryl 1-nitrate (G-1-N) were examined in the rat and in the dog. The level and duration of antianginal and hypotensive activity were the same after single or repeated oral dosage of G-1-N to the anaesthetized rat. The haemodynamic activity of intravenously administered G-1-N in the anaesthetized and thoracotomized dog was dose-dependent. A bolus injection of G-1-N or glyceryl trinitrate (GTN, Nitro Mack) antagonized the cardiovascular activity of intravenously injected dihydroergotamine (DHE) in the anaesthetized and thoracotomized dog. The bioavailability of G-1-N in the rat and in the dog is practically 100%. After intravenous or oral administration to the rat the concentrations of G-1-N in the walls of the vena cava caudalis were markedly higher and in the aorta abdominalis somewhat higher than in the blood or in the other organs examined. G-1-N was eliminated more slowly from the walls of the animals veins than from the walls of the aorta abdominalis or from the blood.
D000787:Angina Pectoris / Q000188:drug therapy*; D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects; D004087:Dihydroergotamine / Q000494:pharmacology; D004285:Dogs; D004562:Electrocardiography; D008236:Lypressin / Q000494:pharmacology; D008297:Male; D005996:Nitroglycerin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D000959:Antihypertensive Agents; D004087:Dihydroergotamine; D008236:Lypressin; C049454:glycerol-1-nitrate; D005996:Nitroglycerin
Hypotensive, antianginöse Wirkung und Pharmakokinetik von Glycerol-1-nitrat an der Ratte und am Hund.