[Kinetic model of a multienzyme system of blood prostanoid synthesis. I. Mechanism of stabilization of thromboxane and prostacyclin levels].
A kinetic scheme of the prostacyclin-thromboxane system has been evolved on the basis of the authors experimental data and the results described elsewhere. The kinetic behavior of the model has been analysed with the aid of computer technology by varying the following parameters: phospholipase activities, free arachidonic acid exchange rates between platelets and endothelium, PGH-synthetase biosynthesis rates, velocities of arachidonic acid pathways other than the cyclooxygenase ones. It has been demonstrated that the biological system is capable of sustaining prostacyclin and thromboxane concentrations at steady fixed levels within a wide range of kinetic parameters.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001792:Blood Platelets / Q000201:enzymology; D011464:Epoprostenol / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000097:blood*; D010740:Phospholipases / Q000097:blood; D011451:Prostaglandin-Endoperoxide Synthases / Q000097:blood; D013379:Substrate Specificity; D013928:Thromboxane A2 / Q000096:biosynthesis* / Q000097:blood
D001095:Arachidonic Acids; D009097:Multienzyme Complexes; D016718:Arachidonic Acid; D013928:Thromboxane A2; D011464:Epoprostenol; D011451:Prostaglandin-Endoperoxide Synthases; D010740:Phospholipases
Kineticheskaia model' polifermentnoĭ sistemy sinteza prostanoidov krovi. I. Mekhanizm stabilizatsii urovneĭ tromboksana i prostatsiklina.