Recombinant human granulocyte colony-stimulating factor induces granulocytosis in vivo.
Recombinant human granulocyte colony-stimulating factor (G-CSF) was prepared and its granulopoietic effects on mice were examined. When mice were injected intraperitoneally with the G-CSF daily for 14 days, marked granulocytosis occurred in the mice. The number of progenitor cells (CFU-C) was remarkably increased in the spleen. The results suggest that G-CSF plays a central role in granulocyte production in vivo.
D000818:Animals; D004274:DNA, Recombinant; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects*; D007377:Interleukin-3 / Q000032:analysis / Q000494:pharmacology*; D007958:Leukocyte Count; D008264:Macrophages / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D009504:Neutrophils
D004274:DNA, Recombinant; D007377:Interleukin-3