Central and peripheral effects of 6-hydroxydopamine on exercise performance in rats.
6-Hydroxydopamine (6-OHDA) injected into the lateral cerebral ventricles of rats impaired their exercise performance until exhaustion (treadmill run and swimming). The injected rats displayed significantly less training-induced improvement of swimming performance than did the control animals. Reduced performance also was seen in adult rats treated intraperitoneally with 6-OHDA in the neonatal or adult periods. The functional impairment can be explained by the neurotoxic action of 6-OHDA on monoamine brain structures (substantia nigra and locus ceruleus) and/or on peripheral sympathetic innervation, the latter assessed by histofluorescence of the iris muscle. The possible contribution of lacticacidemia to the reduced tolerance to stress of 6-OHDA-treated rats by the intracerebroventricular route also is considered.
D000222:Adaptation, Physiological; D000313:Adrenal Medulla / Q000502:physiology; D000818:Animals; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D016627:Oxidopamine; D005082:Physical Exertion / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming; D013564:Sympathetic Nervous System / Q000502:physiology
D006892:Hydroxydopamines; D016627:Oxidopamine