Recovery of age-related decline of thymic endocrine activity and PHA response by lysin-arginine combination.
The frequent association of malnutrition, infectious diseases and aging has stressed the role played by some nutrients on the immune efficiency and by nutrient supplementation on the age-dependent immunological decline. In the present paper there are reported evidences that oral administration of two amino acids--lysine and arginine--recovers, in old Balb/c mice, the mitogen responsiveness, the expression of T-cell markers and the production of thymic serum factor (thymuline). The effect of the amino acids or of their combination, as present in a commercially available form (Neoiodarsolo), seems to consist mainly of the reactivation of the endocrine activity of the thymus. Similar reactivation is achieved also in old humans. These data suggest that the age-dependent decline of thymic hormonal activity is not an intrinsic and irreversible event and that some nutritional intervention, such as amino acid treatment, likely through the stimulation of neuroendocrine network, may reactivate the endogenous production of thymic hormones.
D000375:Aging; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D003601:Cytotoxicity Tests, Immunologic; D008239:Lysine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010835:Phytohemagglutinins / Q000494:pharmacology*; D013935:Thymic Factor, Circulating / Q000032:analysis; D013950:Thymus Gland / Q000187:drug effects / Q000502:physiology*; D013951:Thymus Hormones / Q000097:blood*
D000596:Amino Acids; D010835:Phytohemagglutinins; D013951:Thymus Hormones; D001120:Arginine; D013935:Thymic Factor, Circulating; D008239:Lysine