Investigation of dressings designed for treatment of alveolitis sicca dolorosa ("dry socket"). Part 3: Influence of mannitol and sorbitol on properties of tablets and dressings comprising acetylsalicylic acid, mefenamic acid and aseptin P.
In the dressings for dry tooth sockets, mannitol and sorbitol as solid hydrophilizers have been applied. Increase of concentrations of these hydrophilizers in the tablets results in dressings with increased swelling ability and pharmaceutical availability but decreased viscosity and resistance to washing out. These properties of the dressings are also influenced by medicinal substances present. The dressing fills the tooth socket within several min, removes pain and remain there for 24-48 h.
D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D001241:Aspirin / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D001458:Bandages; D001682:Biological Availability; D004368:Dry Socket / Q000188:drug therapy*; D008353:Mannitol / Q000032:analysis; D008528:Mefenamic Acid / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D009930:Organic Chemicals; D013012:Sorbitol / Q000032:analysis; D013607:Tablets
D000890:Anti-Infective Agents; D009930:Organic Chemicals; D013607:Tablets; D008528:Mefenamic Acid; D008353:Mannitol; D013012:Sorbitol; C051915:aseptin P; D001241:Aspirin