title: The Birmingham Tuberculosis Drug Resistance Register, 1956-1983.
abstract: The findings of the Birmingham Drug Resistance Register are recorded for the years 1956-83. In native born patients initial drug resistance was common up to 1969, but few new cases were discovered after 1970. In the immigrant population a peak of male discoveries was noted in 1968 and a peak of female discoveries in 1979, probably due to immigration patterns. In the native born, single drug resistance was the more common pattern; no initial isoniazid resistance has been detected in this group since 1970. The immigrant patients showed a higher proportion of initial multiple drug resistance. The proportion of culture positive respiratory tuberculosis from which drug resistant bacilli were isolated is given for the years 1976-1983. For native born males this was 1%, for native born females 0.6%, for immigrant males 5.1% and for immigrant females 6.5%. The detections of acquired drug resistance were high in 1956, but since 1970 have fallen to low levels, as has the pool of chronic excretors of drug resistant tubercle bacilli.
mesh_terms: D010131:Aminosalicylic Acid / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004641:Emigration and Immigration; D004739:England; D004977:Ethambutol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008297:Male; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009170:Nontuberculous Mycobacteria / Q000187:drug effects; D012042:Registries; D012293:Rifampin / Q000627:therapeutic use; D013307:Streptomycin / Q000627:therapeutic use; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D010131:Aminosalicylic Acid; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin