In vitro activity of RO 15-8074 and RO 19-5247.
The in vitro activity of RO 15-8074 (cefetamet) and RO 19-5247, new oral cephalosporins, was compared with that of amoxicillin, cephalexin, cefaclor, cefuroxime and erythromycin against 292 clinical isolates using the agar dilution method. Both RO 15-8074 and RO 19-5247 were very active against Proteus mirabilis, Neisseria gonorrhoeae, Haemophilus influenzae and Streptococcus pyogenes, but less active against Staphylococcus saprophyticus and Enterobacter cloacae. RO 19-5247 was more active than RO 15-8074 against Haemophilus influenzae and Streptococcus viridans.
D000658:Amoxicillin / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D015281:Cefmenoxime / Q000031:analogs & derivatives*; D015296:Ceftizoxime / Q000031:analogs & derivatives*; D002511:Cephalosporins / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects; D004917:Erythromycin / Q000494:pharmacology; D006193:Haemophilus influenzae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
D002511:Cephalosporins; C047444:cefetamet; D004917:Erythromycin; C049493:cefteram; D000658:Amoxicillin; D015296:Ceftizoxime; D015281:Cefmenoxime