title: Effects of protein concentration on responses to dietary lysine by chicks.
abstract: Chicks were fed on diets varying in crude protein (CP) content (140 to 280 g/kg diet) in either 8 steps, experiment 1, or 6 steps, experiment 2. Protein composition was held constant in each experiment. At each protein concentration, 5 (experiment 1) or 6 (experiment 2) concentrations of lysine were tested, ranging from 40 to 60 g/kg CP. Growth rate and efficiency of food utilisation to 21 d of age responded to increasing dietary protein contents up to about 230 g CP/kg. An estimate of lysine requirement at each protein concentration was obtained by fitting a quadratic curve to the response data and calculating the dose of lysine (g/kg CP) needed to maximise either growth rate or gain/food ratio. Although no growth response to dietary protein was obtained between 240 and 280 g CP/kg, the amount of lysine needed to maximise growth and gain/food ratio over this range increased systematically when expressed as g/kg diet, but remained constant if expressed as g/kg CP. The regression of lysine required (g/kg diet) for maximum performance (growth or food efficiency) on CP (g/kg diet) was strictly linear for both responses in both experiments throughout the entire range studied (140 g CP/kg to 280 g CP/kg). The estimated lysine requirement was 0.053 of the CP in experiment 1 and 0.055 of the CP in experiment 2. It is concluded that a fixed ratio of lysine to protein should be specified in practical diet formulation, rather than a minimum dietary concentration of lysine. This would ensure that, if the dietary protein content rises above a prescribed minimum value in least-cost formulation, an appropriate adjustment will automatically be made to the lysine content of the solution.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002645:Chickens / Q000254:growth & development*; D004044:Dietary Proteins / Q000494:pharmacology*; D008239:Lysine / Q000378:metabolism* / Q000494:pharmacology; D008297:Male
chemical_list: D004044:Dietary Proteins; D008239:Lysine