title: [Absence of linkage between Alzheimer's disease and the HLA system].
abstract: The study of a family in which multiple cases of Alzheimer's disease occurred in several generations offers the opportunity to test the genetic transmission of this disease. The HLA grouping of the members of a pedigree containing 10 affected members allowed to demonstrate that the disease is not due to a single dominant gene linked to the major histocompatibility complex. Although a more complex involvement of the major histocompatibility complex cannot be totally ruled out it is obvious that a strong linkage does not exist between Alzheimer's disease and HLA.
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D005819:Genetic Markers; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008285:Major Histocompatibility Complex; D008297:Male; D010375:Pedigree
chemical_list: D005819:Genetic Markers; D006680:HLA Antigens
vernacular_title: Absence de liaison entre la maladie d'Alzheimer et le système HLA.