Induction of rat hepatic monooxygenase activity by polychlorinated diphenyl ethers.
Polychlorinated diphenyl ethers are recognized environmental contaminants. Twelve of these compounds were tested for their ability to induce liver cytochrome P-450 and monooxygenase activities in Sprague-Dawley rats. All the compounds increased P-450 levels or increased monooxygenase activities in a manner resembling 3-methylcholanthrene, phenobarbital or a combination of both (mixed). The responses obtained resembled those of the polychlorinated biphenyls, some of which are known to be toxic.
D000633:Aminopyrine N-Demethylase / Q000096:biosynthesis; D000818:Animals; D019363:Cytochrome P-450 CYP1A1; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004790:Enzyme Induction / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D010088:Oxidoreductases / Q000096:biosynthesis*; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls; D010088:Oxidoreductases; D019363:Cytochrome P-450 CYP1A1; D000633:Aminopyrine N-Demethylase