Toxicity due to remission inducing drugs in rheumatoid arthritis. Association with HLA-B35 and Cw4 antigens.
Twenty-five patients with rheumatoid arthritis (RA) who developed toxicity while taking remission inducing drugs and 30 without toxicity were studied for possible associations with class I and II HLA antigens. A strong association has been found between nephritis and dermatitis due to Tiopronin (a D-Penicillamine like compound) and class I antigens B35-Cw4, and between dermatitis due to gold thiosulphate and B35. Compared to healthy controls a lower DR5 frequency was observed in patients with RA except for the Tiopronin related nephritis group.
D000328:Adult; D000368:Aged; D000603:Amino Acids, Sulfur / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology*; D003872:Dermatitis / Q000139:chemically induced; D005260:Female; D006046:Gold / Q000009:adverse effects* / Q000627:therapeutic use; D012971:Gold Sodium Thiosulfate / Q000009:adverse effects* / Q000627:therapeutic use; D006680:HLA Antigens / Q000032:analysis*; D015797:HLA-B35 Antigen; D015236:HLA-C Antigens; D006801:Humans; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000139:chemically induced; D013921:Thrombocytopenia / Q000139:chemically induced; D008625:Tiopronin / Q000009:adverse effects* / Q000627:therapeutic use
D000603:Amino Acids, Sulfur; D006680:HLA Antigens; D015797:HLA-B35 Antigen; D015236:HLA-C Antigens; C039966:HLA-C*04 antigen; D006046:Gold; D008625:Tiopronin; D012971:Gold Sodium Thiosulfate