[Carcinogenic activity of ethylene oxide and its reaction products 2-chloroethanol, 2-bromoethanol, ethylene glycol and diethylene glycol. III. Research on ethylene glycol and diethylene glycol for carcinogenic effects].
Ethylene glycol and diethylene glycol were each administered once weekly subcutaneously to groups of 100 female NMRI mice at 3 dosages (30; 10 und 3 mg single dose per mouse). Tricaprylin was used as solvent. The mean total dosage per mouse was 2110.5; 707.0 and 196.2 mg for ethylene glycol and 2029.8; 671.7 and 213.3 mg for diethylene glycol. Neither ethylene glycol nor diethylene glycol induced tumors at the injection site or away from the point of administration.
D000818:Animals; D000431:Ethanol / Q000031:analogs & derivatives / Q000633:toxicity; D005023:Ethylene Chlorohydrin / Q000633:toxicity; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000008:administration & dosage / Q000633:toxicity*; D005027:Ethylene Oxide / Q000633:toxicity; D005260:Female; D007279:Injections, Subcutaneous; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced*
D005026:Ethylene Glycols; D000431:Ethanol; C013484:diethylene glycol; D005023:Ethylene Chlorohydrin; D019855:Ethylene Glycol; D005027:Ethylene Oxide; C025475:ethylene bromohydrin
Kanzerogene Aktivität von Ethylenoxid und seinen Reaktionsprodukten 2-Chlorethanol, 2-Bromethanol, Ethylenglycol und Diethylenglycol. III. Untersuchung von Ethylenglycol und Diethylenglycol auf kanzerogene Wirkung.