Increase of nonplasmin fibrinolytic activity in the lung and spleen of streptozotocin-induced diabetic rats.
In streptozotocin-induced diabetes in rats, nonplasmin fibrinolytic activity was found to be significantly increased in the lung and spleen, but not in the liver and kidney. The plasminogen-activator activities, either soluble or insoluble, were almost simultaneously increased in the lung, suggesting the possible release of plasminogen-activator from the lung to the blood. It seems likely that plasminogen-activator of the usual type and nonplasmin protease are also involved in thrombotic disorders in the experimental diabetes.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000503:physiopathology*; D010450:Endopeptidases / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D008168:Lung / Q000032:analysis*; D008297:Male; D010960:Plasminogen Activators / Q000097:blood / Q000378:metabolism; D010976:Platelet Count; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000032:analysis*; D010959:Tissue Plasminogen Activator / Q000378:metabolism
D005340:Fibrinogen; D010450:Endopeptidases; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; C032360:spleen fibrinolytic proteinase (human)