[Role of protein poly(ADP-ribosylation) in the radiosensitivity of thymus lymphocytes].
The inhibitors of poly(ADP-ribose) polymerase did not exert a radiomodifying effect on thymocytes. The inhibitors did not also influence single-strand breaks repair in DNA of nucleoids of irradiated cells. The participation of poly(ADP-ribosylation) system in increasing the availability of thymocyte DNA damages for repair enzymes was hardly probable since benzamide in these cells did not influence the level of spontaneous genome lesions recognized by endonucleases. A possible role of protein poly(ADP-ribosylation) in thymocyte DNA repair is discussed.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D004277:DNA, Single-Stranded / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009702:Nucleoside Diphosphate Sugars / Q000528:radiation effects*; D011064:Poly Adenosine Diphosphate Ribose / Q000528:radiation effects*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011506:Proteins / Q000528:radiation effects*; D011836:Radiation Tolerance; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*
D004277:DNA, Single-Stranded; D009702:Nucleoside Diphosphate Sugars; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011506:Proteins; C024857:poly(ADP)-ribosylated proteins; D011064:Poly Adenosine Diphosphate Ribose
Rol' poli(ADF-ribozilirovania) belkov v radiochuvstvitel'nosti limfotsitov timusa.