Effect of teprenone on the content of phospholipids in gastric secretion in man.
The phospholipid content of basal and pentagastrin-stimulated gastric secretion was measured in 9 healthy volunteers. One week oral administration of teprenone did not alter the gastric acid and pepsin secretion. The phospholipid content was increased by teprenone. Changes in subclasses of phospholipids in gastric mucus by teprenone treatment, namely, increased phosphatidylcholine and decreased lysophosphatidylcholine, were observed.
D000328:Adult; D004224:Diterpenes / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000032:analysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D009093:Mucus / Q000032:analysis / Q000378:metabolism; D010434:Pepsin A / Q000378:metabolism; D010743:Phospholipids / Q000032:analysis*
D004224:Diterpenes; D010743:Phospholipids; D010434:Pepsin A; C031049:geranylgeranylacetone