title: Gastric signet-ring cell lymphoma with alpha heavy chains.
abstract: Signet-ring cell lymphomas are rare especially as primary gastric tumours; alpha chain disease of the stomach is also unusual. A case of gastric signet-ring cell lymphoma with free alpha chains in the gastro-duodenal juice is reported and its light microscopic, immunohistological and ultrastructural features are described. Although the morphogenesis of signet-ring cell lymphoma is not clear, the present case showed many of the features of a mucosa-associated lymphoma. This rare variant of follicle centre cell lymphoma may easily be mistaken for a signet-ring cell carcinoma. A search for abnormal immunoglobulins should be made in serum, secretions or tissues in future cases of signet-ring cell lymphoma.
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D004386:Duodenum / Q000378:metabolism; D005750:Gastric Juice / Q000032:analysis; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000032:analysis*; D007137:Immunoglobulin alpha-Chains / Q000032:analysis*; D008223:Lymphoma / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D007143:Immunoglobulin Heavy Chains; D007137:Immunoglobulin alpha-Chains; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone