title: Carcinoma of the extrahepatic biliary system--results of primary and adjuvant radiotherapy.
abstract: From 1975-1983, 20 patients with primary carcinomas of the gallbladder (GB) or extrahepatic bile ducts (EHBD) were irradiated with curative intent at the Washington University Medical Center and affiliated hospitals. Of the 17 patients with EHBD cancer, one received adjuvant irradiation after gross resection with positive microscopic margins. All others received primary irradiation for unresectable tumors, or for gross residual tumor after incomplete resection. The 8 patients receiving Ir192 implant in addition to external radiation showed improved (p = 0.06) survival compared to the 9 receiving external only: median 15 months (range 1.5-34 + months) versus 7 months (range 2.5-21 months). Failures were predominantly local-regional, with only one patient showing metastatic spread without known local-regional tumor. Adjuvant radiation therapy was given after cholecystectomy to 3 patients with GB cancers showing tumor extension beyond the serosa or to regional lymphatics. Of these, two survived at 22+ and 27+ months; the third died of local recurrence at 5 1/2 months. Although numbers are small, these results appear to support the use of adjuvant radiotherapy in patients with microscopic residual GB cancer. Aggressive local and regional radiotherapy can add to the quality and length of survival in both patient groups, that is, those with resectable lesions with high likelihood of microscopic residual, and also those with unresectable or gross residual disease after surgery.
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D001918:Brachytherapy; D003131:Combined Modality Therapy; D005706:Gallbladder Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D007495:Iridium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011868:Radioisotopes / Q000627:therapeutic use; D011882:Radiotherapy, High-Energy
chemical_list: D011868:Radioisotopes; D007495:Iridium