Retinitis pigmentosa: immunohistochemical and biochemical studies of the retina.
Several immunohistochemical and biochemical characteristics of retinas from two patients with retinitis pigmentosa (RP) were examined. Histochemically, interphotoreceptor retinoid-binding protein (IRBP) was found in the interphotoreceptor space in small areas of preserved peripheral retina, although enzyme-linked immunosorbent assay suggested that little IRBP was present. Antibodies to glial fibrillary acidic protein and factor VIII-related antigen corroborated retinal gliosis and retinal vessel attenuation, respectively, in the RP cases. Fibronectin showed similar staining in normal and affected tissue.
D000368:Aged; D000941:Antigens / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D005260:Female; D005353:Fibronectins / Q000378:metabolism; D005654:Fundus Oculi; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D008297:Male; D012160:Retina / Q000378:metabolism* / Q000473:pathology; D012174:Retinitis Pigmentosa / Q000378:metabolism* / Q000473:pathology; D012177:Retinol-Binding Proteins / Q000378:metabolism; D014841:von Willebrand Factor
D000941:Antigens; D005353:Fibronectins; D005904:Glial Fibrillary Acidic Protein; D012177:Retinol-Binding Proteins; D014841:von Willebrand Factor; D005169:Factor VIII