[Determination of the individual sensitivity of human stomach cancer cells to fluoropyrimidines by the cytomorphological criteria of heterotransplants in diffusion chambers].
An optimal morphologic complex of parameters for evaluation of individual sensitivity of heterotransplants to two anti-cancer drugs--5-fluorouracil and ftorafur has been developed on the basis of clinical and experimental material and using 76 gastric malignant tumours, 1320 heterotransplants in diffusion chambers (DC) in vivo which were implanted to 660 animal recipients. A simplified preclinical evaluation method of the individual sensitivity of the human gastric tumour to fluoropyrimidines is recommended based on dynamic level of mitotic activity in DC in vivo heterotransplants.
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D002277:Carcinoma / Q000188:drug therapy* / Q000473:pathology; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009368:Neoplasm Transplantation; D011743:Pyrimidines / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005641:Tegafur / Q000627:therapeutic use*; D013997:Time Factors; D014183:Transplantation, Heterologous; D014410:Tumor Stem Cell Assay
D011743:Pyrimidines; D005641:Tegafur; D005472:Fluorouracil
Opredelenie individual'noĭ chuvstvitel'nosti kletok raka zheludka cheloveka k ftorpirimidinam po tsitomorfologicheskim kriteriiam geterotransplantatov v diffuzionnykh kamerakh.