[Intra-arterial infusion chemotherapy for poor-risk patients with locally advanced bladder cancer--clinical assessment of five cases].
One-shot infusion of anticancer agents via the ligated internal iliac artery after urinary diversion was performed repeatedly in five patients with locally advanced bladder cancer in whom total cystectomy was contraindicated. Drugs infused were adriamycin and/or mitomycin C. Other combination treatments were undertaken before and after this strategy. They included radiation, oral chemotherapy and intravesical instillation of anticancer agents. Adverse reactions did not seem to be clinically significant. Complications were intractable fever, obstruction of the cannula, and prostration, resulting in interruption and discontinuity of this strategy within 11 weeks (in all cases). As a result, PR was achieved in two cases, MR in two, and PD in one according to Koyama-Saito's criteria. This strategy seemed to be promising and effective for locally advanced bladder cancer.
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000556:secondary; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy; D004317:Doxorubicin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000556:secondary
D008937:Mitomycins; D016685:Mitomycin; D004317:Doxorubicin