[Proposal for a new synthetic inhibitor of C1 esterase, methyl-2 thiazoline carbamic ester-3 spirobutenolide: enzyme and electron studies].
The correlation obtained between the electronic properties and the in vitro inhibiting effect on C1 esterase of synthetic derivatives from spirobutenolides series, lead to a synthetic compound. The molecule is especially hopeful in this enzymatic activity and so comparable to the natural inhibitor.
D003166:Complement Activating Enzymes / Q000037:antagonists & inhibitors*; D003174:Complement C1 Inactivator Proteins; D007700:Kinetics; D008722:Methods; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology*
D003174:Complement C1 Inactivator Proteins; D013141:Spiro Compounds; D013844:Thiazoles; C049416:1-oxa-2-oxo-3-methyl-4-(thiazoline carbamoyl)spiro(4.5)decane; D003166:Complement Activating Enzymes
Proposition d'un nouvel inhibiteur synthétique de C1 estérase, le méthyl-2 thiazoline carbamique ester-3 spirobuténolide: études enzymatique et électronique.