title: [Combination of hydantoins and valproate. Evidence of its teratogenic effect in 4 consecutive gestations].
abstract: Four siblings are presented with a malformative syndrome. All were born to an epileptic woman treated with phenytoin and valproic acid. A considerable high fetal pathology is found. Perhaps increased teratogenic effects are related with this pharmacological association not previously described.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000015:Abnormalities, Multiple / Q000139:chemically induced*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D005532:Foot Deformities, Congenital; D006801:Humans; D007223:Infant; D008297:Male; D009958:Orofaciodigital Syndromes / Q000139:chemically induced*; D010672:Phenytoin / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014635:Valproic Acid / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014635:Valproic Acid; D010672:Phenytoin
vernacular_title: Asociación de hidantoínas y valproato. Evidencia de su acción teratogénica en cuatro gestaciones consecutivas.