title: A fundamental problem in determining functional residual capacity or residual volume.
abstract: To measure a lung volume that is not directly accessible, one often follows dilution of a single-gas tracer, present initially only in the lung or in a rebreathing bag. The final volume available to the tracer is assumed to be the sum of the two initial components. Since O2 is taken up and CO2 is eliminated during the few breaths required for mixing, the total volume changes. The error in lung volume due to this volume change can exceed 10%. In this paper we 1) present theoretical and experimental data to demonstrate the effect of CO2 and O2 exchange, 2) introduce a general equation, based on N2 and Ar, which allows one to circumvent the problems created by these fluxes, and 3) show the pitfall of the back-extrapolation approach for a single tracer.
mesh_terms: D001699:Biometry; D002245:Carbon Dioxide; D005652:Functional Residual Capacity; D006801:Humans; D008176:Lung Volume Measurements; D008954:Models, Biological; D010100:Oxygen; D011659:Pulmonary Gas Exchange; D012115:Residual Volume
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen