title: [Active immunization of male pigs against gonadoliberin: effect on the secretion of gonadotropic hormones and on 5 alpha-androst-16-ene-one levels in adipose tissue].
abstract: 27 boars aged 100 days were allocated to 3 experimental groups. The control group was untreated. The 2 other groups were given injections of LHRH, bound to BSA, with either Freund complete adjuvant or alumina gel. 4 immunisations were achieved at weekly intervals and a fifth injection was performed after 4 weeks. In animals treated with alumina gel, no specific antibodies were obtained. In the other hand, all 9 boars treated with FCA exhibited significant titers of specific anti-LHRH antibodies. In these animals, the neutralisation of blood LHRH induced a significant decline in both LH and FSH concentrations. Consequently, fat androstenone levels dropped dramatically, down to low levels, similar to those observed in surgically castrated males.
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000375:Aging; D000736:Androstenes / Q000378:metabolism*; D000818:Animals; D000906:Antibodies; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000276:immunology / Q000502:physiology*; D007110:Immunity, Active; D007167:Immunotherapy; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D013552:Swine
chemical_list: D000736:Androstenes; D000906:Antibodies; C000214:androst-16-en-3-one; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
vernacular_title: Immunisation active du porc mâle contre la gonadolibérine: effets sur la sécrétion d'hormones gonadotropes et sur la teneur en 5 alpha-androst-16-ène-3-one du tissu adipeux.