Increased expression of the c-myc gene without gene amplification in human lung cancer and colon cancer cell lines.
High levels of c-myc mRNA were observed in two human tumor cell lines, a giant cell carcinoma of the lung (C-Lu99) and a colon cancer (C1). The increased expression of c-myc in these cell lines, which was comparable with those in cell lines in which the c-myc gene is amplified, was not due to gene amplification. Run-on transcription revealed that the transcriptional rate of the c-myc gene was greatly increased in these cell lines.
D002460:Cell Line; D003110:Colonic Neoplasms / Q000235:genetics*; D005784:Gene Amplification; D005786:Gene Expression Regulation; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D009857:Oncogenes; D012333:RNA, Messenger / Q000032:analysis; D011995:Recombination, Genetic; D014158:Transcription, Genetic
D012333:RNA, Messenger