In vitro susceptibility of gram-positive cocci to paldimycin.
Paldimycin (U-70138F) is a new antimicrobial agent with activity against gram-positive cocci. Clinical isolates of staphylococci and streptococci were tested. MICs were higher in Mueller-Hinton broth than in nutrient broth. Change in pH had minimal effect on the MICs in either broth. When inoculum size was varied, an inoculum effect was observed. The gram-positive cocci tested were generally more susceptible to paldimycin than to vancomycin.
D000111:Acetylcysteine / Q000031:analogs & derivatives; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003470:Culture Media; D004187:Disaccharides; D013293:Enterococcus faecalis / Q000187:drug effects*; D006020:Glycopeptides / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013696:Temperature; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D003470:Culture Media; D004187:Disaccharides; D006020:Glycopeptides; D014640:Vancomycin; C050461:paldimycin; D000111:Acetylcysteine