title: The effect of naturally occurring Rh antibodies on the survival of serologically incompatible red cells.
abstract: Investigations on six males with naturally occurring Rh antibodies are described. In two subjects in whom the antibody (one anti-E and one anti-D) could be detected only by a two-stage papain technique, the survival of incompatible red cells was normal. In the remaining four subjects, the antibodies (two anti-E and two anti-D) could be detected by the indirect antiglobulin test and, in these, incompatible red cells were destroyed at an accelerated rate; in two of the subjects, 75-99% of the cells were cleared within 24 h; in the other two, 50% of the cells were cleared within 24 h and the remaining cells were cleared far more slowly. All six antibodies were mainly or wholly IgG; a clear-cut immune response was observed in only one case.
mesh_terms: D003298:Coombs Test; D004905:Erythrocyte Aging; D006386:Hemagglutination Tests; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007518:Isoantibodies / Q000032:analysis*; D008297:Male; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D013997:Time Factors
chemical_list: D007074:Immunoglobulin G; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System