Hydroxychavicol: a new phenolic antimutagen from betel leaf.
The phenolic compounds eugenol and hydroxychavicol were separated from betel leaf extract using C18 phase bonded Hiflosil silica gel. The structures of the two compounds were confirmed by nuclear magnetic resonance data. Neither eugenol nor hydroxychavicol was mutagenic when tested in various strains of Salmonella typhimurium with or without metabolic activation. Both compounds exhibited dose-dependent suppression of dimethylbenzanthracene-induced mutagenesis in S. typhimurium strain TA98 with metabolic activation. Hydroxychavicol was more potent than eugenol in this respect.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005054:Eugenol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects; D010936:Plant Extracts / Q000302:isolation & purification / Q000633:toxicity*; D051381:Rats; D012486:Salmonella typhimurium
D010936:Plant Extracts; C051268:2-hydroxychavicol; D005054:Eugenol; D015127:9,10-Dimethyl-1,2-benzanthracene