Functional compensation by transplantation of cell suspensions of embryonic mesencephalon into the striatum of rats with 6-hydroxydopamine lesions.
Neuronal cell suspensions were implanted into the striatum of female rats that showed apomorphine-induced rotation and a reduction in striatal dopamine after intranigral treatment with 6-hydroxydopamine. The apomorphine-induced rotation was significantly suppressed by the transplantation in 12 out of 64 rats. DOPA accumulation and dopamine level (6.3 and 3.4%, respectively, compared with those of uncompensated rats) in the striatum following treatment with an amino acid decarboxylase inhibitor were slightly restored in compensated rats.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003342:Corpus Striatum / Q000502:physiology*; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006834:Hydrazines / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology*; D008636:Mesencephalon / Q000166:cytology / Q000637:transplantation*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013134:Spiperone / Q000494:pharmacology
D006834:Hydrazines; D006892:Hydroxydopamines; D013134:Spiperone; D004295:Dihydroxyphenylalanine; D016627:Oxidopamine; C004297:3-hydroxybenzylhydrazine; D001058:Apomorphine; D004298:Dopamine