[Effect of drugs of the nootropic class on rat behavior after deprivation of the paradoxical stage of sleep].
Pharmacological analysis was used for studying the influence of 24-hour deprivation of paradoxical sleep by Jouvet method on retention of conditioned reaction of passive avoidance in rats. Psychotropic substances of different action were used for the analysis: nootropes as anti-amnestic--pyracetam (400 mg/kg), kleregil (100 mg/kg), centrofenoxin (50 mg/kg) and watersoluble salt of 3-oxypiridin derivative (3-OP) (50 mg/kg) and tranquilizer of bensodiazepine series phenazepam (1 mg/kg) as antistress and antiphobic. It was established that 24-hour deprivation disturbed the elaborated reaction but did not change the rate of emotionality and orienting-investigating behaviour of rats in the open field. Nootropes effectively restored the conditioned passive avoidance reaction while phenazepam had no effect. This allows to suggest that Jouvet method of paradoxical sleep deprivation elicits amnesia and its cause is not only stress but deficit of paradoxical sleep.
D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology; D003642:Deanol; D004338:Drug Combinations / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology; D008297:Male; D002504:Meclofenoxate / Q000494:pharmacology; D008568:Memory / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects*; D010889:Piracetam / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D012892:Sleep Deprivation / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D004338:Drug Combinations; D005971:Glutamates; D011619:Psychotropic Drugs; D011725:Pyridines; D001569:Benzodiazepines; D003642:Deanol; C043253:deanol aceglutamate; C017928:phenazepam; C023500:3-hydroxypyridine; D002504:Meclofenoxate; D010889:Piracetam
Vliianie veshchestv klassa nootropov na povedenie krys v usloviiakh deprivatsii paradoksal'noĭ fazy sna.