title: Acute nonlymphocytic leukemia after thiotepa instillation into the bladder: report of 2 cases and review of the literature.
abstract: We report 2 cases of acute nonlymphocytic leukemia after thiotepa instillation into the bladder for superficial bladder carcinoma and review 4 additional cases from the literature. Intravesical thiotepa is absorbed systemically in patients with bladder carcinoma and such treatment may be associated with the rare occurrence of acute nonlymphocytic leukemia and/or the myelodysplastic syndrome.
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D002291:Carcinoma, Papillary / Q000188:drug therapy; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000139:chemically induced*; D007951:Leukemia, Myeloid / Q000139:chemically induced*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000139:chemically induced; D013852:Thiotepa / Q000008:administration & dosage / Q000009:adverse effects*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
chemical_list: D013852:Thiotepa