[Protective effect of trehalose dimycolate in infestation of mice by Trypanosoma musculi].
Trehalose dimycolate (TDM) treated and untreated mice were infected with Trypanosoma musculi. Compared to untreated mice, treated mice exhibited a five fold reduced number of circulating parasites. Untreated infected mice had a splenomegaly but only a slight increase of spleen weight of treated mice was observed. The role of trehalose dimycolate on T. musculi infection, especially via the macrophage is discussed.
D000818:Animals; D003311:Cord Factors / Q000276:immunology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D006017:Glycolipids / Q000627:therapeutic use*; D051379:Mice; D013163:Splenomegaly / Q000517:prevention & control; D014352:Trypanosomiasis / Q000097:blood / Q000276:immunology / Q000517:prevention & control*
D003311:Cord Factors; D006017:Glycolipids
Effet protecteur du dimycolate de tréhalose lors de l'infestation de la souris par Trypanosoma musculi.