Involvement of sulfatide in activation of protein kinase C by tumor promoters.
Sulfatide (cerebroside sulfate) activated protein kinase C to the same extent as phosphatidylserine did with the tumor promoters, 12-O-tetradecanoylphorbol-13-acetate (TPA), teleocidin and debromoaplysiatoxin. Sulfatide and phosphatidylserine both induced specific binding of [3H]TPA to protein kinase C, although the ratios of specific to non-specific [3H]TPA binding to protein kinase C with the two were not the same. It is concluded that sulfatide is involved in activation of protein kinase C by tumor promoters in a slightly different way from phosphatidylserine.
D000818:Animals; D002273:Carcinogens / Q000378:metabolism*; D002417:Cattle; D002554:Cerebrosides / Q000494:pharmacology*; D000458:Cyanobacteria; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation; D008235:Lyngbya Toxins / Q000494:pharmacology; D010718:Phosphatidylserines / Q000494:pharmacology; D011493:Protein Kinase C / Q000378:metabolism*; D013302:Streptomyces; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D002273:Carcinogens; D002554:Cerebrosides; D008235:Lyngbya Toxins; D010718:Phosphatidylserines; C022176:teleocidins; C017179:debromoaplysiatoxin; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate