title: In-vitro susceptibility of 400 isolates of Neisseria gonorrhoeae in Vancouver, 1982-84.
abstract: Consecutive isolates of Neisseria gonorrhoeae obtained at a sexually transmitted disease clinic in Vancouver between June 1982 and June 1984 were tested for in-vitro susceptibility to eight antimicrobial agents. Of the 400 isolates 6 (1.5%) were penicillinase-producing N. gonorrhoeae, and for 25 (6.2%) the minimum inhibitory concentrations (MICs) of penicillin were 1.0 to 4.0 micrograms/ml. Ceftriaxone sodium was the most active agent. The MICs were higher than those reported in a Canadian study in 1973-74, except for tetracycline hydrochloride. The patterns of susceptibility of the isolates to one antimicrobial agent correlated significantly with those to each other agent, although the relation was weakest for trimethoprim-sulfamethoxazole and spectinomycin. The results reinforce the need to evaluate local in-vitro susceptibility patterns, especially since the proportion of isolates with relative and absolute resistance to penicillin is increasing.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001955:British Columbia; D002443:Ceftriaxone / Q000494:pharmacology; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000302:isolation & purification; D010403:Penicillin Resistance; D010405:Penicillinase / Q000378:metabolism; D010406:Penicillins / Q000494:pharmacology; D013420:Sulfamethoxazole / Q000494:pharmacology; D013754:Tetracyclines / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D010406:Penicillins; D013754:Tetracyclines; D002443:Ceftriaxone; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D010405:Penicillinase; D013420:Sulfamethoxazole