[Movement of Na+ and Cl- across the isolated fetal rat stomach].
Unidirectional and net isotopic fluxes of Na+ and Cl- were determined at steady state across isolated stomach of rat fetuses on days 19 and 21. On day 19, when parietal cells are not yet functional, net absorptions of Na+ and Cl- (respectively: 3.8 +/- 1.1 and 5.2 +/- 1.7 mu eq X h-1 X cm-2) were observed. By contrast, active secretion of Cl- (-2.1 +/- 1.8 mu eq X h-1 X cm-2) associated with decreased absorption of Na+ (45%) was noted on day 21, and both Na+ and Cl- net movements accounted for the short-circuit current, as observed on adult gastric mucosa. These results show that Na+ active absorption precedes Cl- secretion in fetal rat at the time of parietal cells differenciation.
D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D002712:Chlorides / Q000378:metabolism*; D005260:Female; D005333:Fetus; D005753:Gastric Mucosa / Q000196:embryology / Q000378:metabolism*; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*; D013270:Stomach / Q000187:drug effects / Q000196:embryology
D002712:Chlorides; D000584:Amiloride; D012964:Sodium
Mouvements de Na+ et Cl- à travers l'estomac isolé de foetus de rat.