[Selective glutaraldehyde blockade of the sensitivity of arteries to blood flow velocity].
The possibility of selective blockade of arterial sensitivity to flow rate was investigated. The method under study was based on the ability of glutaraldehyde to increase cellular rigidity. As flow-induced arterial dilatation depends on endothelial sensitivity to force, the increased rigidity of endothelial cells leads to the reduction of the dilator stimulus. It was shown that the treatment of endothelium with dimerized glutaraldehyde (0.01-0.03%, 30 sec) removed flow-induced arterial dilatation, without abolishing acetylcholine-evoked dilatation.
D000109:Acetylcholine / Q000494:pharmacology; D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D001783:Blood Flow Velocity; D002339:Carotid Arteries / Q000187:drug effects / Q000502:physiology*; D002415:Cats; D004727:Endothelium / Q000502:physiology; D005263:Femoral Artery / Q000187:drug effects / Q000502:physiology*; D005976:Glutaral / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects
D000447:Aldehydes; D000109:Acetylcholine; D005976:Glutaral
Izbiratel'noe vykliuchenie chuvstvitel'nosti arteriĭ k skorosti krovotoka glutarovym al'degidom.