The use of lidocaine to reduce the pain of myochrysine injections for children with juvenile rheumatoid arthritis.
Myochrysine (gold sodium thiomalate, GSTM) injections are the therapy of choice for children with refractory juvenile rheumatoid arthritis. In this single blinded study 8 children receiving GSTM were asked to rate their discomfort after a total of 185 injections of GSTM to which were added in random fashion either 0, 0.1, or 0.25 ml of 1% lidocaine. The addition of 0.1 ml of lidocaine was associated with a reduction of the mean complaint of pain on an ordinal pain score of 1-10 from 4.32 for injections containing no lidocaine to 2.54 for injections containing 0.1 ml (p less than .01). Addition of 0.25 ml of lidocaine did not provide a significant increase in pain reduction (p greater than .05).
D000293:Adolescent; D000328:Adult; D002648:Child; D004338:Drug Combinations; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007273:Injections, Intramuscular; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control
D004338:Drug Combinations; D006052:Gold Sodium Thiomalate; D008012:Lidocaine