Comparison of serum and coagulum antibiotic levels with respect to protected blood coagulum.
Serum and coagulum antibiotic levels have a parallel course. Coagulum antibiotic concentrations are more than ten times lower than serum concentrations. Therefore the optimal dosage of perioperative infusion should be high enough to establish steady state by means of sufficiently high serum levels. Antibiotics capable of attaining high serum levels and having a long half-life are best suited for the formation of effective antibiotic concentrations in blood coagulum. This is particularly true for cephalosporins and penicillins. Aminoglycoside antibiotics are not recommended for the formation of protected coagulum. "Ceftriaxon in the treatment of Severe bacterial infections".
D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D010068:Oxacillin / Q000097:blood / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D011817:Rabbits
D000900:Anti-Bacterial Agents; D010068:Oxacillin