Structure-activity relationships of selected pyridines. III. Log Kow analysis.
Twenty 2- and 3-position derivatives of pyridine (C5H5N) were tested following a short-term static protocol. Biological activity was monitored as population growth of Tetrahymena pyriformis. These data were combined with previously reported data for twenty 4-position derivatives. Structure-activity relationships were examined using Kow as the physicochemical descriptor. These data form three linear models: one for the non-H-polar derivatives and two for the H-polar derivatives. The latter two models are parallel but have no obvious basis for a priori selectivity. HPLC analysis for toxicant persistence shows that only the smaller non-H-polar derivatives have any significant abiotic loss over the duration of the biological testing.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D007700:Kinetics; D011725:Pyridines / Q000032:analysis / Q000633:toxicity*; D013329:Structure-Activity Relationship; D013769:Tetrahymena pyriformis / Q000187:drug effects
D011725:Pyridines