title: Cytogenetic clones in a recurrent neurofibroma.
abstract: Chromosome studies were performed on a plexiform neurofibroma arising in a probable von Recklinghausen's disease patient, who also showed a de novo constitutional reciprocal translocation, t(1;22)(p32;q11). Banding analysis of the metaphases obtained from two primary cultures in vitro showed the presence of five cytogenetic clones, characterized by different chromosomal rearrangements. In addition to t(1;22), marker chromosomes involved pairs 1, 2, 3, 5, 8, 9, 10, 12, 16, and X. These findings suggest a possible polyclonal evolution in this neurofibroma.
mesh_terms: D000328:Adult; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002892:Chromosomes, Human, Pair 22; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D009455:Neurofibroma / Q000235:genetics* / Q000473:pathology; D009456:Neurofibromatosis 1 / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic
chemical_list: D005819:Genetic Markers