Simultaneous transient erythroblastopenia and agranulocytosis: IgG-mediated inhibition of erythrogranulopoiesis.
We report a case of simultaneous transient erythroblastopenia and agranulocytosis recovering spontaneously. In vitro study using autologous bone marrow cells after recovery demonstrated IgG-mediated inhibition of both erythropoiesis and granulopoiesis but not megakaryopoiesis. The inhibitory activity disappeared shortly after remission. These findings suggest that IgG-mediated inhibition of hematopoiesis may be pathogenetic for transient bone marrow failure of the patient.
D000380:Agranulocytosis / Q000150:complications*; D002675:Child, Preschool; D003114:Colony-Forming Units Assay; D004900:Erythroblasts / Q000166:cytology*; D004920:Erythropoiesis / Q000187:drug effects; D006098:Granulocytes / Q000166:cytology*; D006128:Growth; D006801:Humans; D007074:Immunoglobulin G / Q000502:physiology*; D008264:Macrophages / Q000166:cytology; D008297:Male; D012010:Red-Cell Aplasia, Pure / Q000150:complications*; D012075:Remission, Spontaneous; D013601:T-Lymphocytes / Q000502:physiology
D007074:Immunoglobulin G