The conformation of monkey pituitary somatotropin.
Monkey pituitary somatotropin has been studied by zero-order, second-order, and circular dichroism spectroscopy. Difference absorption spectra have also been generated during proteolytic digestion of the hormone. The molar extinction coefficient of the native protein was found to be 23,800 +/- 550 (M-1 cm-1) at 276.6 nm. A comparison of the conformations of monkey and human pituitary somatotropins indicates a close relationship between the two molecules, including alpha-helix contents of 55 +/- 5%.
D000818:Animals; D002942:Circular Dichroism; D013006:Growth Hormone; D000882:Haplorhini; D006801:Humans; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013820:Thermolysin / Q000378:metabolism
D013006:Growth Hormone; D013820:Thermolysin