Enhancement of graft-versus-host reaction and delayed cutaneous hypersensitivity in mice by ubenimex.
The effect of ubenimex on graft-versus-host reaction and delayed cutaneous hypersensitivity in mice was studied. Ubenimex enhanced the graft-versus-host reaction in a dose range from 0.005 to 0.5 mg/kg. Ubenimex inhibited the aging-caused decrease of delayed cutaneous hypersensitivity to oxazolone and the efficacy was greater with older mice. Ubenimex also inhibited mitomycin C and L1210-caused decreases of delayed cutaneous hypersensitivity to picryl chloride. However, the excess decrease caused by mitomycin C was not significantly altered by ubenimex.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000375:Aging; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006087:Graft vs Host Reaction / Q000187:drug effects*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D008937:Mitomycins; D016685:Mitomycin; D007930:Leucine; C012211:ubenimex