[Peripheral polyneuropathy induced by benzonidazole in the treatment of Chagas' disease].
Neurophysiological examination before and after the administration of benzonidazole, has shown peripheral polyneuropathy induced by this drug in most of the patients treated for chronic Chagas' disease. The polyneuropathy was mostly axonal and it was dose dependent being more severe in patients who had denervation of skeletal muscles before receiving the drug.
D000328:Adult; D014355:Chagas Disease / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D010525:Peripheral Nerves / Q000187:drug effects; D011115:Polyneuropathies / Q000139:chemically induced*; D014344:Trypanocidal Agents / Q000009:adverse effects* / Q000627:therapeutic use
D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C009999:benzonidazole
Polineuropatia periférica induzida por benzonidazol no tratamento da doença de Chagas.