B and T lymphocyte mitogenic properties in a snake venom.
From the crude snake venom of Agkistrodon rhodostoma two mitogenic principles could be detected: A potent T-lymphocyte stimulating anti-beta-D-galactose specific lectin with a molecular mass of about 18 kD and a very strong B-lymphocyte mitogenic factor. Whereas the lectin could be purified by affinity chromatography and characterized as a cell agglutinating, but not precipitating lectin, the highly active B-lymphocyte mitogen could be separated but not characterized. Both factors are much stronger than the mitogens known so far.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003435:Crotalid Venoms / Q000494:pharmacology*; D005685:Galactans; D006385:Hemagglutination Inhibition Tests; D006388:Hemagglutinins; D005779:Immunodiffusion; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008934:Mitogens; D013601:T-Lymphocytes / Q000276:immunology
D003435:Crotalid Venoms; D005685:Galactans; D006388:Hemagglutinins; D037102:Lectins; D008934:Mitogens