[Cytochrome P-450-dependent pathway of oxidation of arachidonic acid and its metabolites].
The experimental data on the role of cytochrome P-450 in the metabolism of arachidonic acid and protanoids in different organs and tissues are analyzed. This system is considered from the standpoint of the possibility to participate in the synthesis of primary prostaglandins. A conclusion is drawn that cytochrome P-450 takes an active part not only in oxidation of different xenobiotics and steroid hormones but also in the synthesis and decomposition of prostaglandins--the most important cell regulators.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism* / Q000494:pharmacology; D002384:Catalysis; D055598:Chemical Phenomena; D002621:Chemistry; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D015237:Dinoprost; D015232:Dinoprostone; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism; D007700:Kinetics; D008862:Microsomes, Liver / Q000201:enzymology; D010084:Oxidation-Reduction; D011453:Prostaglandins / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis; D013379:Substrate Specificity
D001095:Arachidonic Acids; D005230:Fatty Acids, Nonesterified; D007527:Isoenzymes; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D016718:Arachidonic Acid; D003577:Cytochrome P-450 Enzyme System; D015237:Dinoprost; D015232:Dinoprostone
Tsitokhrom P-450-zavisimyĭ put' okisleniia arakhidonovoĭ kisloty i ee metabolitov.