The search for ideal antidote treatment in Gramoxone intoxication.
The herbicide Gramoxone (the active ingredient is paraquat) actively accumulates in the lung in the mammalian organism, where it exerts its toxic effect through the generation of oxygen radicals. Efforts were made to counteract the toxic effect in experiments in mice. Its penetration into the cells was blocked with the diamines putrescine and cadaverine. The synthesis of the prostaglandins, which are supposed by responsible for the acute symptoms, was inhibited with Aspisol. Accumulation inhibition with biogenic amines is considered the most effective.
D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D001241:Aspirin / Q000031:analogs & derivatives / Q000494:pharmacology; D002103:Cadaverine / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008239:Lysine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D051379:Mice; D010269:Paraquat / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000506:poisoning*; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis; D011700:Putrescine / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism
D000931:Antidotes; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D013482:Superoxide Dismutase; D008239:Lysine; D002103:Cadaverine; D010269:Paraquat; D001241:Aspirin; D011700:Putrescine; C010395:acetylsalicylic acid lysinate