Effects of intracarotid hyperosmolar mannitol in triethyl tin (TET)-induced rat brain edema--preservation of blood-brain barrier (BBB) in TET edema.
The effect of intracarotid hyperosmolar mannitol on the blood-brain barrier (BBB) in triethyl tin (TET)-induced rat brain edema was examined by using intravenous Evans blue (EB, MW 68,000) and Adriamycin (ADM, MW 580) as tracers. Three ml of 1.4 M mannitol solution were administered through the right carotid artery during 45 s for BBB opening. The barrier was opened for 60-120 minutes and then re-established. The reversibility was preserved in TET-treated rats and controls. In fact, the intravenous injection of EB stained both TET-treated and non-treated cerebral hemispheres with mannitol-induced transient BBB disruption, but not without BBB disruption. BBB was resistant to both high and low molecular weight substances in TET-induced edema. The importance of this hyperosmotic studies provides the evidence for normal BBB function in TET-induced brain edema.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001929:Brain Edema / Q000139:chemically induced / Q000503:physiopathology*; D002339:Carotid Arteries; D004317:Doxorubicin; D005070:Evans Blue; D006982:Hypertonic Solutions; D007261:Infusions, Intra-Arterial; D008297:Male; D008353:Mannitol / Q000378:metabolism / Q000494:pharmacology*; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains; D014267:Triethyltin Compounds
D006982:Hypertonic Solutions; D014267:Triethyltin Compounds; D008353:Mannitol; D005070:Evans Blue; C031575:triethyltin; D004317:Doxorubicin