Tissue-type plasminogen activator in breast cancer: relationship with estradiol and progesterone receptors.
Plasminogen activator (PA) is an estradiol-inducible enzyme and therefore a potential marker for a functional estradiol receptor (ER) in human breast carcinomas. In this investigation tissue-type PA (t-PA) correlated significantly with both ER and progesterone receptors (PR) in human breast carcinomas. In contrast, neither total PA activity nor urokinase-like PA showed any significant correlation with either ER or PR. Other proteases such as a trypsin-like protease, a chymotrypsin-like protease, and cathepsin B also showed no correlation with ER and PR. It was concluded that the t-PA form of PA may be a marker for a functional ER in breast carcinoma and thus be of value in predicting hormone-dependent breast cancers.
D001943:Breast Neoplasms / Q000032:analysis*; D005260:Female; D006801:Humans; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D010959:Tissue Plasminogen Activator / Q000032:analysis* / Q000276:immunology
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D010959:Tissue Plasminogen Activator