Platelet membrane microparticles in blood bank fresh frozen plasma and cryoprecipitate.
Cryoprecipitate has been demonstrated to correct the bleeding abnormality of patients with some congenital (storage pool disease) and acquired (uremia) platelet abnormalities, but the reason for this effect is unknown. We found significant platelet contamination in plasma harvested to prepare fresh frozen plasma and cryoprecipitate. The platelet membrane microparticles produced by freezing and thawing of the plasma were highly concentrated in cryoprecipitate and may contribute to its therapeutic effect.
D001792:Blood Platelets / Q000648:ultrastructure*; D001793:Blood Preservation; D002462:Cell Membrane / Q000648:ultrastructure; D004340:Drug Contamination; D005169:Factor VIII / Q000627:therapeutic use; D005340:Fibrinogen / Q000627:therapeutic use; D005615:Freezing; D006801:Humans; D010949:Plasma; D010976:Platelet Count
C026912:cryoprecipitate coagulum; D005169:Factor VIII; D005340:Fibrinogen