Neuroleptic drug-induced alterations on neonatal growth and development. I. Prenatal exposure influences birth size, mortality rate, and the neuroendocrine system.
Subcutaneous injection of codeine or phenobarbital, and feeding amphetamine to rats during gestation and lactation caused irregularities in mortality rates, growth, development, and associated neuroendocrine events within the newborns. Most striking was the subnormal birth size, increased mortality rate, and decreased hypothalamic growth hormone-releasing activity of neonates of mothers fed the highest dose of amphetamine.
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001724:Birth Weight / Q000187:drug effects; D003061:Codeine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D013007:Growth Hormone-Releasing Hormone / Q000378:metabolism*; D008098:Litter Size / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D013007:Growth Hormone-Releasing Hormone; D003913:Dextroamphetamine; D003061:Codeine; D010634:Phenobarbital