Immunohistochemical demonstration of carcinoembryonic antigen (CEA) on tissue sections from squamous cell head and neck cancer and plasma CEA levels of the patients.
45 squamous cell head and neck cancers including 36 with carcinoma of the oral cavity and 9 with carcinoma of the maxillary sinus were examined immunohistochemically for the presence of CEA. 12 of 30 carcinomas of the oral cavity and 7 of the 9 carcinomas of the maxillary sinus had tumors containing CEA. This difference in the occurrence of CEA was statistically significant. The mean plasma CEA level of 36 patients with carcinoma of the oral cavity and 7 patients with carcinoma of the maxillary sinus was 1.95 +/- 1.72 ng/ml and 3.70 +/- 3.53 ng/ml, respectively. Significant elevation of plasma CEA levels was found only in the stage-IV group patients with carcinoma of the oral cavity as compared with the stage-I group patients. In the 3 patients having plasma CEA values exceeding 5 ng/ml at the time of pretherapy, plasma CEA levels were decreased to below 2.5 ng/ml with the cancer treatment followed by the complete remission. These findings indicate that plasma CEA as a tumor marker in squamous cell head and neck cancer is meaningful in a small proportion of the cancer patient population.
D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis* / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000032:analysis* / Q000097:blood / Q000473:pathology; D005260:Female; D005887:Gingival Neoplasms / Q000032:analysis / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000032:analysis* / Q000097:blood / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000032:analysis / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D010157:Palatal Neoplasms / Q000032:analysis / Q000473:pathology
D002272:Carcinoembryonic Antigen