A quantitative dynamic concept of the interphase partition of lipids: application to bile salt-lecithin-cholesterol mixed micelles.
A system is proposed for a quantitative classification of lipids, based on interphase partition coefficients. This system enables calculation of exchanges of lipid molecules between phases. The mass/volume chemical unit mol X cm-3, strictly derived from the CGS system, is used, thus simplifying mathematical relations. Applied to bile salt-lecithin-cholesterol mixed micelles, this dynamic concept gives new insight into the variations of physico-chemical parameters. Experimental results obtained with the glycodesoxycholate and the taurocholate show a striking difference in partition coefficients between aqueous and mixed bile salt-lecithin interfacial phases. A new model applying triangular co-ordinates to a bile salt-lecithin-cholesterol mixed lipid phase is described.
D001647:Bile Acids and Salts; D055598:Chemical Phenomena; D002621:Chemistry; D002784:Cholesterol; D007700:Kinetics; D008055:Lipids; D008433:Mathematics; D008823:Micelles; D008968:Molecular Conformation; D008970:Molecular Weight; D010713:Phosphatidylcholines
D001647:Bile Acids and Salts; D008055:Lipids; D008823:Micelles; D010713:Phosphatidylcholines; D002784:Cholesterol