title: An enhanced serum prolactin response to TRH in the presence of GABA transaminase inhibition.
abstract: Patients with epilepsy were found to have an increased 20 minute prolactin response to intravenous TRH stimulation when receiving the GABA-T inhibiting drug vigabatrin. Enhanced GABA activity may either reduce basal prolactin levels whilst allowing a normal pituitary response to TRH stimulation, or may overcome the inhibitory effects of dopamine on pituitary prolactin release.
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000293:Adolescent; D000328:Adult; D000614:Aminocaproates / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D011388:Prolactin / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D013997:Time Factors; D020888:Vigabatrin
chemical_list: D000614:Aminocaproates; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D013972:Thyrotropin; D000612:4-Aminobutyrate Transaminase; D020888:Vigabatrin