[Effect of ryanodine on the electrical and mechanical activity of frog atrial fibers].
The effect of ryanodine on the action potential, slow inward current and mechanical activities of frog atrial fibres was studied by means of the double sucrose gap technique. Ryanodine was shown to reduce the amplitude of the slow inward current, to cause an intracellular Ca accumulation and to decrease the tonic component of the tension.
D000200:Action Potentials / Q000187:drug effects; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D016275:Atrial Function; D002118:Calcium / Q000378:metabolism; D006321:Heart / Q000502:physiology*; D006325:Heart Atria / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D011898:Ranidae; D012433:Ryanodine / Q000494:pharmacology*; D013779:Tetrodotoxin / Q000494:pharmacology
D000470:Alkaloids; D012433:Ryanodine; D013779:Tetrodotoxin; D002118:Calcium
Effet de la ryanodine sur l'activité électrique et mécanique des fibres atriales de Grenouille.