title: Evolutionary role of posttranslational modifications of proteins, as illustrated by the glycosylation characteristics of the digestive enzyme pancreatic ribonuclease.
abstract: The glycosylation characteristics of the digestive enzyme ribonuclease are summarized. The evolutionary role of this posttranslational modification is discussed and evidence is presented that selection has much influence on the presence or absence of carbohydrate in glycoproteins and on the positions of the carbohydrate attachment sites.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D006023:Glycoproteins / Q000235:genetics*; D008958:Models, Molecular; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D012259:Ribonuclease, Pancreatic / Q000235:genetics*; D013045:Species Specificity
chemical_list: D006023:Glycoproteins; D012259:Ribonuclease, Pancreatic