Endocrine studies in patients with isolated gonadotrophin-releasing hormone deficiency.
Twelve black women with isolated gonadotrophin deficiency were studied. After administration of intravenous gonadotrophin-releasing hormone (GnRH), all patients had subnormal gonadotrophin responses. However, after priming with subcutaneous GnRH (in 9 patients) follicle-stimulating hormone responses improved in 4 patients and luteinizing hormone responses in 7 patients. Prolactin responses to intravenous thyrotrophin-releasing hormone were significantly decreased at 20 and 60 minutes, when compared with reference subjects (P less than 0.01). In response to insulin-induced hypoglycaemia, prolactin responses were heterogeneous in 11 patients, while those of growth hormone were suboptimal in 8 of the 11 patients tested.
D001741:Black or African American; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000502:physiology; D006801:Humans; D007275:Injections, Intravenous; D007331:Insulin Coma / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood / Q000502:physiology; D010906:Pituitary Hormone-Releasing Hormones / Q000008:administration & dosage / Q000172:deficiency* / Q000494:pharmacology; D011388:Prolactin / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage; D013997:Time Factors
D010906:Pituitary Hormone-Releasing Hormones; D004958:Estradiol; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin