[Treatment of cyclic attacks of acute intermittent porphyria with an LH-RH agonist administered by the intranasal route].
A 31 year old woman suffering of acute intermittent porphyria (AIP) developed within 9 months 7 cyclical attacks occurring in a average of 5,2 days before menses. In order to inhibit ovulation, we experiment a long-acting agonist LH-RH (D-SER (TBU) 6-EA10 LH-RH--Buserelin) administered during 8 months by nasal spray. Menses did not occur during the test and the patient developed only 2 attacks. The initial ovarian stimulation phase lasted 15 days and was marked by the induction of an AIP attack after 3 days of treatment and occurrence of ovarian cysts. Our case suggests that LH-RH analogues may be useful in the prevention of cyclical attacks of porphyria.
D000208:Acute Disease; D000281:Administration, Intranasal; D000328:Adult; D002064:Buserelin / Q000008:administration & dosage*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D010060:Ovulation / Q000187:drug effects; D011164:Porphyrias / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology
D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D002064:Buserelin
Traitement d'une porphyrie aiguë intermittente avec attaques cycliques par un agoniste LH-RH administré par voie nasale.