title: [Comparative biochemical and electron microscopic research on the membrane-damaging action of a chemical carcinogen on the endoplasmic reticulum in vivo and in vitro].
abstract: The results of a comparative biochemical and electron-microscopic study of membrane-injuring effect of N-nitrosodimethylamine--a chemical carcinogen widespread in the environment are reviewed. It has been established that in vivo and in vitro membrane-injuring effect of nitrosodimethylamine is characterized by reduced activity of membrane-bound enzymes of endoplasmic reticulum (UDP-glucuronyltransferase and glucose-6-phosphatase) accompanied by alterations in functional morphology of cells and intracellular structure.
mesh_terms: D000650:Amnion / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D000818:Animals; D002478:Cells, Cultured; D004128:Dimethylnitrosamine / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D013997:Time Factors
chemical_list: D005954:Glucosephosphate Dehydrogenase; D014453:Glucuronosyltransferase; D004128:Dimethylnitrosamine
vernacular_title: Sravnitel'noe biokhimicheskoe i élektronno-mikroskopicheskoe issledovanie membranopovrezhdaiushchego deĭstviia khimicheskogo kantserogena na éndoplazmaticheskiĭ retikulum in vivo i in vitro.