title: Effects of triethyltin bromide on protein phosphorylation in subcellular fractions from rat and rabbit brain.
abstract: Phosphorylation of specific proteins in subcellular fractions of rat brain is affected by the presence of low concentrations (1-50 microM) of triethyltin bromide (Et3SnBr), in vitro. SDS-PAGE and autoradiography showed that Et3SnBr increased phosphorylation of an Mr = 42,000 phosphorylation of an Mr = 52,000 component. The Mr = 42,000 and 76,000-80,000 phosphoproteins have been identified as the alpha-subunit of pyruvate dehydrogenase (PDH) and synapsin, respectively. Et3SnBr-induced phosphorylation of rabbit brain PDH results in partial inactivation of the PDH complex.
mesh_terms: D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010766:Phosphorylation; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D011817:Rabbits; D013347:Subcellular Fractions / Q000187:drug effects / Q000378:metabolism; D016704:Synapsins; D014220:Trialkyltin Compounds / Q000494:pharmacology*; D014267:Triethyltin Compounds / Q000494:pharmacology*
chemical_list: D009419:Nerve Tissue Proteins; D011768:Pyruvate Dehydrogenase Complex; D016704:Synapsins; D014220:Trialkyltin Compounds; D014267:Triethyltin Compounds; C026405:bromotriethylstannane