New species of messenger RNA in aflatoxin B1 induced hepatocellular carcinoma.
Differences in the mRNA species were observed when cDNA complementary to HnRNA from normal liver was hybridized with mRNA from hepatocellular carcinoma induced by aflatoxin B1. The hybridizations between cDNA complementary to HnRNA from liver cell carcinoma and HnRNA from normal liver indicate that there is homology between their sequences. The findings in this paper suggest that mRNA species normally restricted to the cell nucleus are present in the cytoplasm of liver carcinoma cells.
D016604:Aflatoxin B1; D000348:Aflatoxins; D000818:Animals; D002273:Carcinogens; D004247:DNA / Q000302:isolation & purification; D008099:Liver / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics*; D008297:Male; D009693:Nucleic Acid Hybridization; D012332:RNA, Heterogeneous Nuclear / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains
D000348:Aflatoxins; D002273:Carcinogens; D012332:RNA, Heterogeneous Nuclear; D012333:RNA, Messenger; D004247:DNA; D016604:Aflatoxin B1