title: Effects of weekly and daily pretreatment with gold sodium thiomalate on adjuvant induced arthritis.
abstract: The effect of gold sodium thiomalate on adjuvant induced arthritis in DA rats was investigated. Ten mg/kg gold given in either weekly or daily injections before the administration of adjuvant was able to decrease the severity of arthritis in these animals. One mg/kg gold given as daily injections had no effect on adjuvant induced arthritis. One mg/kg gold given as weekly injections before adjuvant administration reduced the severity of arthritis to a level which was intermediate between that seen in the placebo control and the 10 mg/kg gold groups. The proliferative responses of spleen cells to mitogens in these animals were not altered by in vivo gold therapy.
mesh_terms: D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D004334:Drug Administration Schedule; D005260:Female; D005620:Freund's Adjuvant; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D011859:Radiography; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000378:metabolism / Q000473:pathology; D013936:Thymidine / Q000378:metabolism
chemical_list: D006052:Gold Sodium Thiomalate; D005620:Freund's Adjuvant; D013936:Thymidine