Inhibition of mammalian digestive disaccharidases by polyhydroxy alkaloids.
Several polyhydroxy alkaloids, including the eight presently known to occur in plants, have been compared as inhibitors of mouse gut digestive disaccharidases. The indolizidine castanospermine inhibited all activities tested, but others showed a selectivity which could be of value in studies of carbohydrate digestion and errors of metabolism.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004186:Disaccharidases / Q000037:antagonists & inhibitors*; D005260:Female; D050113:Imino Furanoses; D066298:In Vitro Techniques; D007212:Indolizines; D007413:Intestinal Mucosa / Q000201:enzymology; D007422:Intestines / Q000201:enzymology*; D008353:Mannitol / Q000031:analogs & derivatives; D051379:Mice; D011759:Pyrrolidines; D017026:Swainsonine; D054836:Indolizidines
D000470:Alkaloids; D004186:Disaccharidases; D050113:Imino Furanoses; D007212:Indolizines; D008353:Mannitol; D011759:Pyrrolidines; D017026:Swainsonine; C043121:2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine; C037806:castanospermine; D054836:Indolizidines