title: Breakpoint distribution in variant Philadelphia translocations in chronic myeloid leukemia.
abstract: A statistical analysis of the 327 cases of variant Philadelphia chromosome so far reported in chronic myeloid leukemia was performed. The results showed 28 bands to be significantly rearranged; 11 bands are known to contain a fragile site; 12 are included in the smallest region of overlap of 14 proto-oncogenes. Also, 23 bands are known to be significantly involved in structural rearrangements in other malignancies.
mesh_terms: D016590:Aphidicolin; D002110:Caffeine / Q000494:pharmacology; D002871:Chromosome Banding; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D004224:Diterpenes / Q000494:pharmacology; D005492:Folic Acid / Q000494:pharmacology; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D009857:Oncogenes; D010677:Philadelphia Chromosome
chemical_list: D004224:Diterpenes; D016590:Aphidicolin; D002110:Caffeine; D005492:Folic Acid