title: The effect of alpha-difluoromethylornithine on ornithine decarboxylase activity in compensatory growth of mouse lung.
abstract: After removing the left upper lobe, the remaining lung of mice undergoes compensatory growth. Increased ornithine decarboxylase activity is characteristic of the process. The effect of alpha-difluoromethylornithine was studied on the ornithine decarboxylase (E.C.4.1.1.17.) activity and on the lung growth in mice after lobectomy. Although a single injection of alpha-difluoromethylornithine inhibited ornithine decarboxylase activity, the compensatory growth of lung still occurred in spite of continuous alpha-difluoromethylornithine treatment. This suggests that polyamines, indispensable for compensatory growth, may be supplied by other sources.
mesh_terms: D000818:Animals; D000518:Eflornithine / Q000494:pharmacology*; D005260:Female; D008168:Lung / Q000187:drug effects / Q000201:enzymology* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011013:Pneumonectomy; D012038:Regeneration / Q000187:drug effects*
chemical_list: D009955:Ornithine Decarboxylase; D000518:Eflornithine