Hepatitis and neutropenia secondary to gold thiomalate therapy for rheumatoid arthritis.
A 37 year old female with rheumatoid arthritis developed clinical and biochemical evidence of hepatitis after receiving 80 mg of sodium aurothiomalate. Inadvertent rechallenge with sodium aurothiomalate led to recurrence of the biochemical abnormalities and a profound neutropenia and eosinophilia.
D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D001772:Blood Cell Count; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006052:Gold Sodium Thiomalate / Q000009:adverse effects*; D006801:Humans; D008111:Liver Function Tests; D009503:Neutropenia / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology
D006052:Gold Sodium Thiomalate