title: A synthesis of N6,N6,N6-trimethyl-L-lysine dioxalate in gram amounts.
abstract: A procedure is described for the synthesis of crystalline N6,N6,N6-trimethyl-L-lysine dioxalate in gram amounts starting from the commercially available N2-tert-butoxycarbonyl-N6-benzyloxycarbonyl-L-lysine, which is reacted with methyl iodide in methanol in the presence of potassium hydrogen carbonate after deprotection of the side-chain amino group by catalytic hydrogenation. The work-up involves only filtrations and evaporations.
mesh_terms: D000818:Animals; D007202:Indicators and Reagents; D008239:Lysine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism
chemical_list: D007202:Indicators and Reagents; C003712:trimethyllysine; D008239:Lysine