The effect of hypoxia on the activity of purine nucleoside phosphorylase in rats.
The activity of purine nucleoside phosphorylase (PNP) in rat erythrocytes fractionated by centrifugation in microhematocrit capillaries was studied. After seven-day hypoxia (54 kPa) the PNP activity was increased by 67 +/- 4% (S.E.M.) in the lightest fraction of erythrocytes; on the fifth day after hypoxia PNP activity did not differ from control values.
D000818:Animals; D004912:Erythrocytes / Q000201:enzymology; D000860:Hypoxia / Q000097:blood / Q000201:enzymology*; D008297:Male; D010430:Pentosyltransferases / Q000097:blood*; D011683:Purine-Nucleoside Phosphorylase / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D010430:Pentosyltransferases; D011683:Purine-Nucleoside Phosphorylase