Influence of polyethylene glycol 6000 and mannitol on the in-vitro dissolution properties of nitrofurantoin by the dispersion technique.
Employing the dispersion technique the influence of mannitol and polyethylene glycol (PEG) 6000 on the in-vitro dissolution of nitrofurantoin was investigated. Dispersions of the drug with PEG 6000 showed faster dissolution rates when compared with dispersions of the drug in mannitol. Tablet formulation of the drug--PEG 6000 dispersion exhibited better drug releasing properties as compared to tablets prepared from the drug's PEG 6000 physical mixture, or the drug's formulation with Avicel PH 101.
D002855:Chromatography, Thin Layer; D008353:Mannitol; D009582:Nitrofurantoin / Q000032:analysis*; D011092:Polyethylene Glycols; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D013607:Tablets; D008353:Mannitol; D011092:Polyethylene Glycols; D009582:Nitrofurantoin