Translocation of oncogene c-sis from chromosome 22 to chromosome 17 in a human myelogenous leukemia cell line.
By combining somatic cell genetics, in situ hybridization and Southern hybridization, we found that the c-sis oncogene in the human myelogenous leukemia cell line ML3 is translocated from the long arm (q11----qter) of chromosome 22 to the long arm (mid-portion or q21 region) of chromosome 17. This translocation does not result in rearrangement of the c-sis oncogene.
D002460:Cell Line; D002886:Chromosomes, Human, Pair 17; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D066298:In Vitro Techniques; D007951:Leukemia, Myeloid / Q000235:genetics*; D011519:Proto-Oncogenes; D014178:Translocation, Genetic