Coronary artery deposition of factor VIII-related antigen in ischemic heart disease.
This study localized Factor VIII-related antigen (FVIIIRAg) directly in the intramural coronary arteries of patients with coronary artery disease (CAD). Assays were performed on myocardial autopsy sections from 17 patients with and 15 patients without CAD, using a monospecific FVIIIRAg antibody in the peroxidase-immunoperoxidase technic. FVIIIRAg was quantified by a FVIIIRAg index (FRI), as a numerical score based on distribution, thickness, and extension of immunostaining. The mean FRI for the CAD patients was 55 +/- 11 and that for the control patients 12 +/- 5 (P less than 0.001). The increased amounts of in situ FVIIIRAg suggest this glycoprotein may be involved in the pathogenesis of atherosclerosis.
D000941:Antigens / Q000032:analysis*; D003327:Coronary Disease / Q000473:pathology*; D003331:Coronary Vessels / Q000032:analysis*; D005169:Factor VIII / Q000032:analysis / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D014841:von Willebrand Factor
D000941:Antigens; D014841:von Willebrand Factor; D005169:Factor VIII