Monoclonal gammopathy in beta thalassaemia.
A rare instance of IgG-kappa monoclonal gammopathy in a patient with beta-thalassaemia trait is reported. The patient had a smoldering multiple myeloma with no apparent clinical symptoms pertaining to the disease and was a non-responder to conventional Melphalan and prednisolone therapy. Beta-thalassaemia trait was detected while investigating him for anaemia. A state of altered immunological reactivity, chronic infections and associated biliary tract disease are some of the pathogenetic mechanisms suggested. However in this patient none of these were operative.
D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications; D013789:Thalassemia / Q000150:complications*
D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains