Pregnancy after combined treatment with bromocriptine and tamoxifen in two patients with pituitary prolactinomas.
Two patients with prolactinomas who could not tolerate a large dose of bromocriptine were treated with combination of bromocriptine and tamoxifen. This combined therapy normalized the PRL level and restored a regular ovulatory cycle, which resulted in pregnancy.
D000328:Adult; D000818:Animals; D001971:Bromocriptine / Q000627:therapeutic use*; D002143:Callitrichinae; D004359:Drug Therapy, Combination; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013629:Tamoxifen / Q000627:therapeutic use*
D013629:Tamoxifen; D001971:Bromocriptine; D011388:Prolactin; D005640:Follicle Stimulating Hormone