title: Effects of zeranol on reproduction in beef bulls: luteinizing hormone, follicle-stimulating hormone, and testosterone secretion in response to gonadotropin-releasing hormone and human chorionic gonadotropin.
abstract: Effects of zeranol on the maturation of the adenohypophyseal-gonadal axis were studied in beef bulls. Calves were implanted with 36 mg of zeranol at 3-month intervals from birth through 6 months of age (group 2, n = 10) or were not treated (control group 1, n = 10). After 9 months, group-2 calves were given implants of 36 mg of zeranol at 3-month intervals through 18 months of age (group 2B, n = 5) or were not reimplanted (group 2A, n = 5). Areas under the curves outlined by concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone for 6 hours after the administration of 100 micrograms of gonadotropin-releasing hormone (GnRH) were calculated. Gonadotropin-releasing hormone was administered at 3-month intervals from 1.5 through 19.5 months of age. Areas under the curves for concentrations of testosterone for 4 hours after the administration of 10,000 IU of human chorionic gonadotropin (HCG) at 4.5, 7.5, and 10.5 months or 1,000 IU at 13.5 and 16.5 months of age also were calculated. The amount of FSH released was greater (P less than 0.05) for group-2 than for group-1 calves at 4.5 and 7.5 months of age. The amount of FSH released in groups 2A and 2B tended (P less than 0.10) to be greater than that for group 1. Significant differences between groups 2A and 2B were not observed. The amount of LH released at 7.5 months of age was less for groups 1 and 2 than that at earlier ages, and the decrease was greater (P less than 0.05) for group 2.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000818:Animals; D002417:Cattle / Q000502:physiology*; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D004343:Drug Implants; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology*; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D012118:Resorcinols / Q000494:pharmacology*; D013739:Testosterone / Q000378:metabolism*; D015029:Zeranol / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D006063:Chorionic Gonadotropin; D004343:Drug Implants; D006065:Gonadotropins, Pituitary; D010906:Pituitary Hormone-Releasing Hormones; D012118:Resorcinols; D013739:Testosterone; D015029:Zeranol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone