title: Central 6-hydroxydopamine and renal sodium retention in mineralocorticoid-treated rats.
abstract: Cerebroventricular administration of 6-hydroxydopamine attenuated the development of deoxycorticosterone hypertension in the rat but did not affect the initial period of renal sodium retention. However, escape from the sodium retention was greater in 6-hydroxydopamine-treated rats. These data support the hypothesis that destruction of central catecholamine-containing neurons influences the renal handling of sodium. The enhanced escape may lead to diminished total body sodium, which attenuates the development of deoxycorticosterone hypertension.
mesh_terms: D000818:Animals; D003900:Desoxycorticosterone / Q000633:toxicity*; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D007276:Injections, Intraventricular; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*
chemical_list: D006892:Hydroxydopamines; D003900:Desoxycorticosterone; D016627:Oxidopamine; D012964:Sodium