title: Photosensitized reactions of nucleic acids.
abstract: The main effects of near-ultraviolet and visible light on cellular DNA are reviewed with emphasis on base lesions, oligonucleotide single-strand breaks and DNA-protein cross-links. Model system photosensitization reactions of DNA are also discussed. This includes photodynamic effects, menadione-mediated photooxidation, photoionization of antibiotics, the photochemistry of 5-halogenopyrimidines and urocanic acid.
mesh_terms: D010129:4-Aminobenzoic Acid; D000818:Animals; D000970:Antineoplastic Agents; D001412:Bacillus subtilis / Q000235:genetics; D001976:Bromouracil / Q000031:analogs & derivatives; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000528:radiation effects*; D004260:DNA Repair; D004269:DNA, Bacterial / Q000528:radiation effects; D003630:Daunorubicin / Q000528:radiation effects; D004317:Doxorubicin / Q000528:radiation effects; D004926:Escherichia coli / Q000235:genetics; D005609:Free Radicals; D006147:Guanine; D006415:Hematoporphyrins; D006801:Humans; D008027:Light; D009705:Nucleosides; D010084:Oxidation-Reduction; D010100:Oxygen / Q000494:pharmacology; D010777:Photochemistry; D011740:Pyrimidine Dimers / Q000528:radiation effects; D011743:Pyrimidines; D012395:Rose Bengal; D026082:Singlet Oxygen; D014466:Ultraviolet Rays; D014529:Uridine / Q000031:analogs & derivatives; D014560:Urocanic Acid; D014812:Vitamin K
chemical_list: D000970:Antineoplastic Agents; D004269:DNA, Bacterial; D005609:Free Radicals; D006415:Hematoporphyrins; D009705:Nucleosides; D011740:Pyrimidine Dimers; D011743:Pyrimidines; D014812:Vitamin K; D026082:Singlet Oxygen; D012395:Rose Bengal; D001976:Bromouracil; D006147:Guanine; D004317:Doxorubicin; D004247:DNA; D014560:Urocanic Acid; C006824:5-bromouridine; D010100:Oxygen; D010129:4-Aminobenzoic Acid; D014529:Uridine; D003630:Daunorubicin