Transfer from immediate-release disopyramide to controlled-release disopyramide.
Simulation of serum disopyramide concentrations during transfer from steady-state immediate-release (IR) disopyramide to a sustained-release disopyramide preparation was performed based on pharmacokinetic parameters obtained from IR disopyramide and serum concentrations measured following an initial dose of controlled-release (CR) disopyramide phosphate. Based on the results of simulation, a typical patient with good cardiac, renal, and hepatic function can be transferred from a q 6 h IR disopyramide to an equivalent daily dose of controlled-release disopyramide administered q 12 h beginning at 6 hours after the final IR disopyramide dose.
D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D004206:Disopyramide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D007700:Kinetics
D000889:Anti-Arrhythmia Agents; D003692:Delayed-Action Preparations; D004206:Disopyramide