The 70-Kd neisserial common antigen is a surface-exposed, antigenically stable peptidic structure.
A previously described 70-Kd antigen present in all Neisseria gonorrhoeae strains tested and in most Neisseria species was characterized as a mercaptoethanol-and heat-stable protein. Using mouse polyclonal antisera specifically directed against this antigen, it was shown that it is a surface-exposed structure. The 70-Kd antigen was recovered from all gonococcal strains isolated from different anatomic sites in male and female partners, thus demonstrating its antigenic stability after in vivo transmission in humans.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis*; D001345:Autoradiography; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006801:Humans; D007122:Immunoelectrophoresis; D051379:Mice; D009344:Neisseria gonorrhoeae / Q000276:immunology*
D000954:Antigens, Surface