Effect of single and repeated treatment of chlordiazepoxide and sodium valproate on water intake in the rat and their influence on the antidipsogenic action of naloxone.
The action of single and repeated treatment with chlordiazepoxide (CDP) (5-10 mg/kg i.p.) and sodium valproate (VPA) (100-200 mg/kg i.p.) on water intake of rats adapted to a daily 23-h water deprivation schedule was investigated. The influence exerted by single or repeated treatment of the two drugs on the antidipsogenic effect of naloxone (Nx) (1 mg/kg s.c.) was studied too. Our results show that with single treatment of CDP the dipsogenic effect is lower and not further modified by increasing dose and by the time-course of the session; with repeated treatment the dipsogenic effect is greater and further enhanced by increasing dose and by the time-course of the session. Single or repeated treatment with VPA does not significantly affect the water intake. Single treatment of CDP enhances the antidipsogenic effect of Nx, while CDP, after repeated treatment, reverses the antidipsogenic effect of Nx. With VPA-Nx association, the response is univocal (antidipsogenic effect) independent of the experimental conditions. The results are briefly discussed.
D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects*; D004347:Drug Interactions; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014635:Valproic Acid / Q000494:pharmacology*
D009270:Naloxone; D014635:Valproic Acid; D002707:Chlordiazepoxide