Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5.
The drug-metabolizing UDP glucuronosyltransferases are encoded by genes which constitute a multigene family. One rat gene subfamily codes for at least four constitutive enzyme forms, including those which glucuronidate the androgenic steroids testosterone (UDPGTr-3) and androsterone (UDPGTr-4). In the present study, UDPGTr-3 and UDPGTr-4 cDNAs were used to demonstrate that an homologous subfamily is present in the mouse genome. Using mouse X Chinese hamster somatic cell hybrids, we mapped at least one gene of this UDP glucuronosyltransferase subfamily (UDPGTr-3) to mouse chromosome 5 and suggest the name as the Udpgt-3 locus.
D000818:Animals; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000235:genetics; D008040:Genetic Linkage; D014453:Glucuronosyltransferase / Q000235:genetics*; D006822:Hybrid Cells; D051379:Mice; D009693:Nucleic Acid Hybridization; D051381:Rats
D004247:DNA; D014453:Glucuronosyltransferase