title: Pentylenetetrazol-induced convulsion and effect of anticonvulsants in mutant inbred strain El mice.
abstract: The El mouse is an inbred strain developed from ddY mice and is very susceptible to seizure. In El mice, convulsions could be induced by 18 mg/kg of pentylenetetrazol, which is an inert dose in ddY mice. The features of the convulsions were the same as those induced by the tossing-up procedure, a common method to evoke convulsions in El mice. Phenytoin, phenobarbital, valproate sodium, and ethosuximide clearly inhibited pentylenetetrazol-induced convulsions in El mice. These findings suggest that induction of convulsions by pentylenetetrazol in the El mouse is a simple method as compared with induction of convulsions by the tossing-up procedure, and convulsions evoked by this method are a precise experimental model for the study of hereditary epilepsy and for the evaluation of anticonvulsant drugs.
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D005013:Ethosuximide / Q000627:therapeutic use; D051379:Mice; D008817:Mice, Mutant Strains; D010433:Pentylenetetrazole; D010634:Phenobarbital / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D005013:Ethosuximide; D014635:Valproic Acid; D010672:Phenytoin; D010433:Pentylenetetrazole; D010634:Phenobarbital