[Demonstration of an oxidative biotransformation of 9-methoxyellipticine. Comparison with the case of 9-hydroxyellipticine].
Evidences for the formation of the glutathione-hydroxyellipticine adduct during the rat metabolism of 9-methoxyellipticine are provided. These data suggest that such a cytotoxic molecule might behave as a pro-alkylating agent in vivo.
D000470:Alkaloids / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D004611:Ellipticines / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000470:Alkaloids; D000970:Antineoplastic Agents; D004611:Ellipticines; C008009:9-hydroxyellipticine; C001729:9-methoxyellipticine
Mise en évidence d'une biotransformation oxydante de la méthoxy-9-ellipticine. Comparaison avec le cas de l'hydroxy-9-ellipticine.