title: [Mutagenic activity in the feces of normal people on a mixed diet].
abstract: Single fecal samples of 25 people, living on a normal mixed Western diet and matched for freedom from any gastrointestinal disorder, were freeze-dried and volatile compounds were collected at -60 degrees C. The residues were extracted with n-hexane-dichloromethane 1:1, and subsequently with acetone-ethylacetate 2:1. The three fractions were assayed for mutagenic activity using the Salmonella typhimurium mammalian microsomal system. Fecal mutagenic activity was observed with the tester strain TA 98 in 28% of the assayed people without microsomal activation, and in 4% of the people with strains TA 98 and TA 100 with microsomal activation.
mesh_terms: D000368:Aged; D000818:Animals; D004032:Diet; D005243:Feces / Q000032:analysis*; D005260:Female; D005612:Freeze Drying; D006801:Humans; D008297:Male; D008875:Middle Aged; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis*; D051381:Rats
chemical_list: D009153:Mutagens
vernacular_title: Mutagene Aktivitäten in Fäzes mischkosternährter Normalpersonen.