The role of MAO in MPTP toxicity--a review.
MPTP is oxidized to its toxic metabolite MPP+ by MAO B in both primate and rodent brains and this reaction can be inhibited by (-)-deprenyl. MPTP can also act as an inhibitor of both MAO A and B. There is some evidence that MAO B is localized predominantly in glia, and this would explain why dopamine uptake blockers also can prevent MPTP toxicity. The possibility that molecules with a similar action to MPTP cause idiopathic Parkinson's disease is discussed.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D001921:Brain / Q000201:enzymology; D055598:Chemical Phenomena; D002621:Chemistry; D000882:Haplorhini; D006861:Hydrogen Peroxide / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors; D009457:Neuroglia / Q000201:enzymology; D009474:Neurons / Q000201:enzymology; D010084:Oxidation-Reduction / Q000187:drug effects; D010300:Parkinson Disease / Q000209:etiology; D011725:Pyridines / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity*; D051381:Rats; D012642:Selegiline / Q000494:pharmacology; D013045:Species Specificity; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; D011725:Pyridines; D012642:Selegiline; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D006861:Hydrogen Peroxide; D008995:Monoamine Oxidase