title: Clearance of maltose administered at different infusion rates.
abstract: Maltose is a disaccharide consisting of 2 molecules of d-glucose which at 10% solution is isotonic with plasma but provides a caloric supply double than glucose. Its possible use in total parenteral nutrition was investigated. Two homogeneous groups of patients were infused during a 2-hour period with a 10% maltose solution at 0.2 g/kg/h and at 0.4 g/kg/h flow rate. The data collected during and at the end of infusion demonstrate that: 1) the major metabolic parameters do not undergo significant alterations after maltose infusion; 2) the infusion at 0.4/kg/h causes an osmotic diuresis that does not significantly affect the water-electrolyte balance of the patients. Nevertheless it is not possible to exclude that this condition may lead to negative side-effects in critical patients; 3) the urinary excretion of maltose and glucose is significantly higher in the group of patients with 0.4 g/kg/h infusion rate.
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D004334:Drug Administration Schedule; D006801:Humans; D007328:Insulin / Q000097:blood; D008320:Maltose / Q000008:administration & dosage* / Q000097:blood; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D011182:Postoperative Care; D011897:Random Allocation
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008320:Maltose