Decrease in lipogenesis and glucose oxidation of rat adipose tissue after chronic ethanol feeding.
This investigation was performed to determine whether chronic ethanol feeding affects adipose tissue lipogenesis and glucose metabolism. Female Wistar rats were pair-fed nutritionally adequate liquid diets containing ethanol as 36% of energy or an isocaloric amount of carbohydrate for 3 weeks. Chronic ethanol feeding resulted in a depression of adipose tissue lipogenesis as assessed by labeled glucose incorporation into glyceride glycerol and glyceride fatty acids. Glucose oxidation was also impaired after chronic ethanol feeding. Such changes may contribute to the postprandial hypertriacyglyceridemia observed in alcoholics.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002250:Carbon Radioisotopes; D003847:Deoxyglucose / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D066298:In Vitro Techniques; D008055:Lipids / Q000096:biosynthesis*; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism
D002250:Carbon Radioisotopes; D008055:Lipids; D014280:Triglycerides; D002245:Carbon Dioxide; D000431:Ethanol; D003847:Deoxyglucose; D005947:Glucose