Assessment of thrombogenicity of activated and non-activated prothrombin concentrates in a rat model.
In vitro clotting activity of rats injected with different preparations of prothrombin concentrates was measured. Animals rendered deficient in vitamin K-dependent coagulation factors by early coumadin (warfarin) pretreatment, followed by injections of concentrate preparations were also evaluated. Findings indicate a dose-related response in abnormal coagulation changes demonstrable with each preparation and lack of protection of intravascular coagulation by coumadin anticoagulation. Furthermore, a role for in vivo factor VII activation of haemostasis following concentrate administration could not be elicited.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D004305:Dose-Response Relationship, Drug; D005169:Factor VIII / Q000037:antagonists & inhibitors; D008297:Male; D011516:Prothrombin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014859:Warfarin / Q000494:pharmacology
D001779:Blood Coagulation Factors; D014859:Warfarin; D011516:Prothrombin; D005169:Factor VIII