title: Ontogenetic development of pancreatic thyrotropin-releasing hormone in human foetuses and in infants.
abstract: The ontogeny of thyrotropin-releasing hormone (TRH) in pancreata of human foetuses from 15-36 weeks of gestation and of infants has been studied. TRH was detectable in the pancreas of a 15 week old foetus; a progressive increase of pancreatic TRH content was observed until the 34th week of gestation, whereas a progressive decrease was found in the late period of pregnancy and in 1 year old infants. In contrast, the pancreatic insulin content showed a progressive increase during the entire pregnancy and in the first year after birth. These data indicate that TRH and insulin have different ontogenetic patterns in the human pancreas.
mesh_terms: D005260:Female; D005333:Fetus / Q000378:metabolism; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007328:Insulin / Q000378:metabolism; D010179:Pancreas / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D011247:Pregnancy; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism*
chemical_list: D007328:Insulin; D013973:Thyrotropin-Releasing Hormone