Apolipoproteins AI, AII and B in young adults: associations with CHD risk factors. The Beaver County experience.
Although the associations of lipoprotein lipids and apoproteins with coronary heart disease (CHD) risk factors have been examined in middle-aged populations, there is little data among younger subjects where these associations may be stronger. The authors quantitated apolipoproteins AI, AII and B as well as lipoprotein lipids in 172 young adults (aged 20-24 years) from a defined population in Beaver County, Penn. and examined cross-sectional associations with known risk factors. Female nonusers of oral contraceptives (OC) had higher mean concentrations of HDL-C and lower levels of LDL-C and triglycerides than men (p less than 0.05) although there was no significant sex difference in apo AI (p greater than 0.10), while apo B was higher among men (p less than 0.01). OC use was positively related to apo AI and AII (p less than 0.05) but not to HDL-C. Cigarette smoking was inversely associated with apo AI, AII and HDL-C while alcohol intake was positively associated with these factors. These results suggest that in general, correlates of lipoprotein lipids and apoproteins in young adults parallel those in middle-aged subjects and suggest further that quantitation of both at an early age may help prevent CHD and further elucidate the atherosclerotic process.
D000328:Adult; D000428:Alcohol Drinking; D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001054:Apolipoproteins A / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D003276:Contraceptives, Oral / Q000008:administration & dosage; D003327:Coronary Disease / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D012306:Risk; D012907:Smoking; D012959:Socioeconomic Factors; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003276:Contraceptives, Oral; D014280:Triglycerides