Activation of complement and coagulation in juvenile dermatomyositis.
In patients with juvenile dermatomyositis (JDM), small vessel occlusion and thrombosis result in a decrease in the capillary: muscle fiber ratio. We studied 15 patients with JDM. Six of 7 patients with clinically active JDM had elevated levels of C3d. Moreover, concentrations of fibrinopeptide A and factor VIII-related antigen were significantly increased in patients with clinically active JDM.
D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000032:analysis; D001777:Blood Coagulation; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis*; D015933:Complement C3d; D003882:Dermatomyositis / Q000097:blood / Q000276:immunology*; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D005260:Female; D005344:Fibrinopeptide A / Q000032:analysis; D006801:Humans; D008297:Male; D014841:von Willebrand Factor
D000941:Antigens; D003176:Complement C3; D014841:von Willebrand Factor; D005344:Fibrinopeptide A; D015933:Complement C3d; D005169:Factor VIII