[Effect of tranquilizers on lipid peroxidation of biological membranes].
Thirty-seven patients with unstable angina pectoris were treated with prolonged-action nitrates for 20 days; 8 of these received additionally meprobamate in a dose of 0.4 g per day and 11 patients received phenazepam in a dose of 0.002 g per day. The addition of tranquillizers to the complex of treatment led to a significant decrease of one of the final products of biological membrane lipid peroxidation--Schiff's bases in erythrocytic membranes. During treatment with phenazepam a similar decrease was more rapid (by the 5th day of treatment) and more pronounced.
D000368:Aged; D000789:Angina, Unstable / Q000097:blood / Q000188:drug therapy; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors / Q000097:blood*; D008620:Meprobamate / Q000627:therapeutic use; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use; D010084:Oxidation-Reduction / Q000187:drug effects; D012545:Schiff Bases / Q000097:blood; D014149:Tranquilizing Agents / Q000627:therapeutic use*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D003692:Delayed-Action Preparations; D008054:Lipid Peroxides; D012545:Schiff Bases; D014149:Tranquilizing Agents; D001569:Benzodiazepines; C017928:phenazepam; D008620:Meprobamate; D005996:Nitroglycerin
Vliianie trankvilizatorov na perekisnoe okislenie lipidov biologicheskikh membran.