title: Learning impairment following lesion of the basal nucleus of Meynert in the marmoset: modification by cholinergic drugs.
abstract: Five common marmosets (Callithrix jacchus) received unilateral ibotenic acid lesions of the basal nucleus of Meynert (nBM). Seven days later, choline acetyltransferase activity was significantly reduced by 50% in the frontal and temporal neocortex, 40% in the amygdala, and approximately 30% in the motor, parietal and occipital cortex in the ipsilateral hemisphere. Four marmosets receiving equivalent bilateral ibotenic acid lesions were severely impaired on new visual object discrimination learning and on relearning an object discrimination learnt prior to surgery when compared with operated controls. New learning in lesioned animals was substantially improved by i.m. administration of the cholinergic agonist arecoline. Lesioned animals' learning ability improved with time but these animals were then differentially sensitive to the disruptive effect of scopolamine on discrimination learning. These results show that lesions of the nBM which destroy the rising cholinergic pathways impair learning ability but that this ability can be substantially restored by administration of a cholinergic agonist.
mesh_terms: D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D001479:Basal Ganglia / Q000502:physiology*; D002143:Callitrichinae; D004192:Discrimination, Psychological / Q000187:drug effects; D005260:Female; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010277:Parasympathomimetics / Q000494:pharmacology*; D012153:Retention, Psychology / Q000187:drug effects; D012193:Reversal Learning / Q000187:drug effects; D012601:Scopolamine / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D013377:Substantia Innominata / Q000502:physiology*
chemical_list: D010277:Parasympathomimetics; D012965:Sodium Chloride; D001115:Arecoline; D012601:Scopolamine; D000109:Acetylcholine