[Antiaggregation action and pharmacokinetics of lysine acetylsalicylate].
Lysine acetylsalicylate, a water-soluble salt of acetylsalicylic acid, administered intravenously to rabbits (15 and 100 mg/kg) and also in vitro (2-10 mg/ml) produced antiaggregational and anticoagulant effects pertaining to acetylsalicylic acid. Pharmacokinetics of acetylsalicylic acid injected intravenously to rabbits in the form of lysine acetylsalicylate is formalized by a biexponential equation for a two-compartment model. The main pharmacokinetic constants of acetylsalicylic acid in these experiments were found to be similar to those in humans.
D000818:Animals; D001241:Aspirin / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D007700:Kinetics; D008239:Lysine / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D012996:Solutions; D013997:Time Factors
D012996:Solutions; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate
Antiagregatsionnoe deĭstvie i farmakokinetika atsetilsalitsilata lizina.