title: Effect of adrenoceptor blockers on the acinar enlargement induced by Chagas' disease in the rat submandibular glands.
abstract: Chagas' disease induces acinar enlargement in the submandibular salivary gland of rats inoculated with the Y strain of Trypanosoma cruzi at the age of 27-28 days and killed 18 days after inoculation (acute phase). Propranolol, a beta-adrenoceptor blocker, prevents the acinar enlargement induced by T. cruzi infection. Phenoxybenzamine, an alpha-adrenoceptor blocker, enhances this enlargement. These results suggest that catecholamines are involved in the genesis of the acinar hypertrophy induced by Chagas' disease.
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000150:complications*; D006984:Hypertrophy; D010643:Phenoxybenzamine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D013363:Submandibular Gland / Q000187:drug effects / Q000473:pathology*
chemical_list: D010643:Phenoxybenzamine; D011433:Propranolol