[A study on UFT concentration in tissues and serum of patients with malignant gynecologic tumors following oral administration].
UFT was orally given at a dose of 200 mg twice a day to seven female patients with malignant gynecological tumors. Measurements of blood and tissue concentrations of tegafur (TF), fluorouracil (FU) and uracil (U) showed that the concentrations of both FU and U were clearly increased. The ratio of concentration in the tumor to that in peripheral blood was 9.3, while that of the concentration in the internal iliac lymph nodes to that in the internal iliac artery was 11.2. The changes in blood levels of the three compounds were determined one and five days after UFT administration. There was a distinct difference in the blood levels of the drug among TF, FU and U. TF reached its peak concentration two hours after breakfast and four hours after supper; both FU and U reached their peak concentrations two hours after breakfast and one hour after supper. Furthermore, TF showed a tendency to accumulate after continuous administration, but this was not the case with FU or U. These findings suggest that even during continuous administration, the blood level of FU remains low.
D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005472:Fluorouracil / Q000097:blood; D005833:Genital Neoplasms, Female / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism; D010053:Ovary / Q000378:metabolism; D005641:Tegafur / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism; D014498:Uracil / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism; D014599:Uterus / Q000378:metabolism
D005641:Tegafur; D014498:Uracil; D005472:Fluorouracil