title: Primary sclerosing cholangitis in the presence of a lupus anticoagulant.
abstract: Lupus anticoagulant, an immunoglobulin that prolongs the partial thromboplastin time, has been associated with thrombotic events, including deep venous thrombosis, pulmonary emboli, and Budd-Chiari syndrome. In this report, primary sclerosing cholangitis was diagnosed in a man with a 10-year history of multiple thrombotic events related to a circulating lupus anticoagulant. Progressive jaundice and pruritus developed, and sclerosing cholangitis was confirmed by direct cholangiography. Sclerosing cholangitis is the second hepatobiliary disease reported in association with a lupus anticoagulant.
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000097:blood; D001779:Blood Coagulation Factors / Q000032:analysis / Q000037:antagonists & inhibitors*; D002758:Cholangiography; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002761:Cholangitis / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D006500:Hepatic Duct, Common / Q000473:pathology*; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D008297:Male; D012598:Sclerosis / Q000473:pathology
chemical_list: D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor