[Preventive properties of the blood sera from persons vaccinated with a Proteus vaccine made from soluble antigen complexes].
In experiments of the passive protection of mice the protective properties of sera obtained from humans before and after their immunization with Proteus vaccine used as a monopreparation or in combination with staphylococcal toxoid and/or pyoimmunogen were studied. When introduced in a single subcutaneous injection, Proteus vaccine prepared from soluble antigenic complexes ensured an increase in the protective properties of sera. The second injection of the vaccine essentially enhanced the protective potency of the sera of the immunized donors. The therapeutic injection of Proteus vaccine ensured the essential increase of the protective properties of the sera. This increase could be experimentally detected within at least 25-30 days from the beginning of immunization. The immunization of volunteers with Proteus vaccine in combination with pyoimmunogen and adsorbed staphylococcal toxoid ensured the maximum increase of the protective properties of their sera.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000276:immunology* / Q000302:isolation & purification; D007116:Immunization, Passive; D008297:Male; D051379:Mice; D011512:Proteus Infections / Q000517:prevention & control; D011514:Proteus vulgaris / Q000276:immunology*; D054406:Pseudomonas Vaccines; D011550:Pseudomonas aeruginosa / Q000276:immunology; D012995:Solubility; D013208:Staphylococcal Toxoid / Q000276:immunology; D013997:Time Factors; D014611:Vaccination; D017778:Vaccines, Combined
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D007106:Immune Sera; D054406:Pseudomonas Vaccines; D013208:Staphylococcal Toxoid; D017778:Vaccines, Combined; C039987:polyvalent pseudomonas vaccine
Preventivnye svoĭstva syvorotok krovi liudeĭ, vaktsinirovannykh proteĭnoĭ vaktsinoĭ iz rastvorimykh antigennykh kompleksov.