fos oncogene transfer to a transformed rat fibroblast cell line enhances spontaneous lung metastasis in rat.
When investigating the relationship of different oncogenes to metastasis, we found that transfer of the v-fos oncogene into a transformed rat cell line augmented spontaneous lung metastasis. The metastatic potential of the cell lines examined depended on the manner of integration and the extent of transcription of the fos genes. Thus, the fos oncogene is probably involved in certain events related to acquisition of metastatic potential.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D005347:Fibroblasts; D008175:Lung Neoplasms / Q000556:secondary; D009362:Neoplasm Metastasis; D009857:Oncogenes; D051381:Rats; D014158:Transcription, Genetic; D014162:Transfection