In vitro formation of a triazene compound by reaction of sulphadimidine and nitrite.
The interaction between the veterinary drug sodium sulphadimidine and nitrite has been studied under acid conditions and the formation of 1,3-di-(4-[N-(4,6-dimethyl-2-pyrimidinyl)sulphamoylphenyl)triazene (DDPSPT) was demonstrated. This compound was not mutagenic when tested on Salmonella typhimurium and Drosophila melanogaster. In addition to the formation of DDPSPT, desaminosulphadimidine was identified as a minor reaction product.
D000818:Animals; D004331:Drosophila melanogaster; D009682:Magnetic Resonance Spectroscopy; D009152:Mutagenicity Tests; D009573:Nitrites; D013055:Spectrophotometry, Infrared; D013418:Sulfamethazine; D014226:Triazenes
D009573:Nitrites; D014226:Triazenes; C053071:1,3-di-(4(N-(4,6-dimethyl-2-pyrimidinyl))sulfamoylphenyl)triazene; D013418:Sulfamethazine