The utility of a single-point dosing protocol for predicting steady-state lithium levels.
Two methods for predicting steady-state serum lithium level were compared prospectively in in-patients suffering from affective disorder. A single-point prospective administration model that required a single 24-hour serum lithium level, following a test dose produced statistically similar predictions of the observed steady-state lithium levels as did a model that required 12- and 36-hour levels. However, the latter two-point method produced significantly more accurate predictions from clinical interpretation. Although the two-point approach is preferable, the single-point method is clinically acceptable if its limitations of accuracy are taken into consideration.
D000328:Adult; D004334:Drug Administration Schedule; D006801:Humans; D008094:Lithium / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D016651:Lithium Carbonate; D008954:Models, Biological; D019964:Mood Disorders / Q000097:blood / Q000188:drug therapy*; D011446:Prospective Studies
D016651:Lithium Carbonate; D008094:Lithium