Design and synthesis of a hapten for the radioimmunoassay of bupropion.
The synthesis of a hapten useful in the radioimmunoassay of bupropion is described. Since bupropion has no functional group that can be easily derivatized, a hydroxypropyl group was incorporated into the molecule. Studies in cross-reactivity with possible metabolites required the synthesis of the 4'-hydroxy analogue of bupropion. This synthesis is also described.
D016642:Bupropion; D003429:Cross Reactions; D006241:Haptens / Q000032:analysis; D011427:Propiophenones / Q000032:analysis*; D011863:Radioimmunoassay
D006241:Haptens; D011427:Propiophenones; D016642:Bupropion