Effect of dietary fat on aflatoxin B1-induced chromosomal aberrations in mice.
The effect on the frequency of aflatoxin B1 (AFB1)-induced chromosomal aberrations in bone marrow cells of mice fed diets containing increasing levels of sesame oil was investigated. Mice receiving either 9% or 12% sesame oil in their diet for 8 weeks presented a statistically increased AFB1-induced aberration rate as compared to those given a diet containing 3% sesame oil. These data suggest that the metabolism of a mutagen can be influenced by the dietary lipid intake of the test animal.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D004041:Dietary Fats / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D008297:Male; D008677:Metaphase; D051379:Mice; D012715:Sesame Oil / Q000494:pharmacology*
D000348:Aflatoxins; D004041:Dietary Fats; D012715:Sesame Oil; D016604:Aflatoxin B1