title: Effects of protective immune serum on the yields of parasites and pulmonary cell reactions in schistosome-infected rats.
abstract: Yields of parasites during the period of worm migration from the lungs to the portal circulation were measured in S. mansoni-infected Fischer rats passively immunized with protective serum from twice-infected donor rats. Two effects of protective serum were observed in recipient rats relative to normal serum recipients: yields of schistosomula from lungs were higher and yields of (immature) worms from the portal circulation were lower throughout the period analyzed. Histopathological analysis of lung tissue confirmed the presence of greater numbers of schistosomula in lungs of passively immunized rats. In addition, the percent of lung schistosomula involved in all categories of inflammatory reactions was greater in recipients of protective rat serum. The kinetics of accumulation of worms perfused from the portal circulation of normal and passively immunized rats indicate that in the latter group a smaller fraction of worms successfully migrates to the portal circulation. These findings support the hypothesis that protective activity of the serum prevents a portion of worms from successfully completing migration from the lung to the portal circulation.
mesh_terms: D000818:Animals; D005260:Female; D007106:Immune Sera / Q000276:immunology; D007116:Immunization, Passive; D007249:Inflammation; D007700:Kinetics; D008168:Lung / Q000469:parasitology / Q000473:pathology; D008297:Male; D051379:Mice; D011168:Portal System / Q000469:parasitology; D051381:Rats; D011919:Rats, Inbred Strains; D012550:Schistosoma mansoni / Q000276:immunology / Q000502:physiology; D012555:Schistosomiasis mansoni / Q000276:immunology* / Q000469:parasitology / Q000473:pathology
chemical_list: D007106:Immune Sera