Limitations in the use of indium-111-oxine-labeled leucocytes for the diagnosis of occult infection in children.
Fifteen children underwent scintigraphy with indium 111 (111In)-labeled white blood cells (WBC) for the detection of a local suppuration. The procedure generally contributed to a correct diagnosis. False negative results were observed in 5 children, but in two of them positive foci were also present. The missed lesions were 2 liver abscesses, 1 lung abscess, foci of osteomyelitis and 1 pericarditis. Two cases of chronic granulomatous disease are presented in which increased leucocyte accumulation was not observed in proven instances of infection.
D000293:Adolescent; D001424:Bacterial Infections / Q000000981:diagnostic imaging*; D002648:Child; D005188:False Negative Reactions; D005490:Focal Infection / Q000000981:diagnostic imaging*; D006105:Granulomatous Disease, Chronic / Q000000981:diagnostic imaging*; D006801:Humans; D006912:Hydroxyquinolines; D007205:Indium Radioisotopes; D007962:Leukocytes; D008297:Male; D009942:Organometallic Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives; D011877:Radionuclide Imaging
D006912:Hydroxyquinolines; D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C032950:indium oxine; D015125:Oxyquinoline