Ovarian follicular maturation in women. I. Intermittent versus daily administration of human menopausal gonadotropin.
This study was designed to compare the efficiency of daily intramuscular human menopausal gonadotropin (hMG) therapy to an intermittent subcutaneous regimen in women with ovulatory dysfunction. Ovarian follicular development was assessed with the use of serial ultrasound scans and serum 17 beta-estradiol (E2) levels. Ovulation was based on pregnancy and/or elevated luteal progesterone values. There were no significant differences between the two treatment regimens, based on E2 levels, follicular size, and/or number of follicles greater than 1.0 cm. Pregnancy and ovulation occurred more frequently after intramuscular hMG therapy. These results indicate that daily hMG is preferred over intermittent subcutaneous administration because of convenience.
D000328:Adult; D000858:Anovulation / Q000188:drug therapy; D004958:Estradiol / Q000097:blood; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D008596:Menotropins / Q000008:administration & dosage* / Q000009:adverse effects; D006080:Ovarian Follicle / Q000502:physiology*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D014463:Ultrasonography
D011374:Progesterone; D004958:Estradiol; D008596:Menotropins