[Changes in the mass transfer of blood gases in hypoxia during infusion of and emulsion of perfluorocarbons].
Systemic hemodynamic parameters, physico-chemical homeostasis and blood rheology were studied using the model of anemic hypoxia after substitution of the blood with salt solution exceeding the blood loss, with or without additional administration of perfluorocarbon (PFC) emulsion. The data obtained suggest that physiological reactions of O2 deficiency compensation in anemic hypoxia (increased O2 extraction, improved heart performance) can be substantially improved if the PFC emulsion is present in the blood flow as the PFC seems to enhance the mass transfer of blood gases.
D000740:Anemia / Q000150:complications*; D000818:Animals; D001692:Biological Transport; D001802:Blood Substitutes / Q000627:therapeutic use*; D002245:Carbon Dioxide / Q000378:metabolism*; D004285:Dogs; D004338:Drug Combinations; D005466:Fluorocarbons / Q000008:administration & dosage*; D006439:Hemodynamics; D000860:Hypoxia / Q000188:drug therapy* / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*
D001802:Blood Substitutes; D004338:Drug Combinations; D005466:Fluorocarbons; D002245:Carbon Dioxide; C039422:perfluorotripropylamine; C008805:perfluorodecalin; D010100:Oxygen
Izmenenie massoperenosa gazov krovi v usloviiakh gipoksii pri infuzii émul'sii perftoruglerodov.