Baclofen exacerbates epileptic myoclonus in kindled rats.
Electrically kindled rats exhibit myoclonic jerks (1-25/min for 30-90 min) when injected with 200 mg/kg i.p. cysteamine. L-Baclofen, 10 mg/kg i.p. injected 45 min prior was not anticonvulsant but rather exacerbated the myoclonus. Furthermore, baclofen itself induced myoclonus in 29% of kindled rats at 10 mg/kg and in 100% of kindled rats at 15 mg/kg. These findings suggest that caution should be exercised before proposing the use of baclofen as an anticonvulsant or indeed using baclofen in patients who are predisposed to seizures.
D000818:Animals; D001418:Baclofen / Q000633:toxicity*; D003543:Cysteamine; D004558:Electric Stimulation; D004831:Epilepsies, Myoclonic / Q000139:chemically induced*; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003543:Cysteamine; D001418:Baclofen