L-deprenyl attenuates stress ulcer formation in rats.
Both intraperitoneal and intracerebroventricular (i.c.v.) administration of the monoamine oxidase-B inhibitor L-deprenyl markedly attenuated restraint stress-induced gastric ulcers in rats. L-Deprenyl given i.c.v. attenuated stress ulcers in microgram doses and virtually abolished ulcer formation at a dose of 2.0 micrograms. These data suggest that intact or augmented central dopaminergic function may be an essential component of gastric mucosal protection.
D000818:Animals; D000897:Anti-Ulcer Agents; D004298:Dopamine / Q000502:physiology; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D010627:Phenethylamines / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012642:Selegiline / Q000008:administration & dosage / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications* / Q000503:physiopathology
D000897:Anti-Ulcer Agents; D010627:Phenethylamines; D012642:Selegiline; D004298:Dopamine