High-voltage irradiation and hydroxyurea for pulmonary leukostasis in acute myelomonocytic leukemia.
A 29-year-old man with acute myelomonocytic leukemia had an initial leukocyte count of 192 X 10(9) cells/l and 84% blasts. During the initial treatment with hydroxyurea, 1 g/m2 orally tid, he developed pulmonary leukostasis which responded rapidly to whole-lung radiation with 1.5 Gy in one fraction. Pulmonary leukostasis in hyperleukocytotic AML is an oncologic emergency demanding rapid intervention. The combined treatment with chemotherapy and radiation appears useful.
D000328:Adult; D003131:Combined Modality Therapy; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use*; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008171:Lung Diseases / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D008297:Male; D011882:Radiotherapy, High-Energy
D006918:Hydroxyurea