title: Vitamin B-6 nutriture and plasma diamine oxidase activity in pregnant Hispanic teenagers.
abstract: Vitamin B-6 status was assessed by measuring erythrocyte glutamic-pyruvic transaminase (EGPT) indices in 122 pregnant Hispanic teenagers. Seventeen percent were vitamin B-6 deficient (EGPT indices greater than 1.25) at the initial interview (first or second trimester). A daily supplement of 5 mg vitamin B-6, beginning at initial interview, did not reduce prevalence of vitamin B-6 deficiency at final interview (third trimester). No association was found between EGPT indices greater than 1.25 and the outcome of pregnancy. The activity of diamine oxidase (DAO), a vitamin B-6-dependent enzyme produced by the placental decidua, was measured in maternal plasma. At initial and final interviews, plasma-DAO activity was increased by in vitro addition of pyridoxal-5'-phosphate. The activity in early pregnancy was positively associated with dietary vitamin B-6 intake and was lower in teenagers with EGPT indices greater than 1.25 at the final interview. Findings suggest that plasma-DAO activity is influenced by vitamin B-6 status.
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000201:enzymology / Q000208:ethnology*; D011253:Pregnancy in Adolescence; D011732:Pyridoxal Phosphate / Q000494:pharmacology; D011736:Pyridoxine / Q000097:blood / Q000627:therapeutic use; D014804:Vitamin B Deficiency / Q000188:drug therapy / Q000201:enzymology / Q000208:ethnology*
chemical_list: D011732:Pyridoxal Phosphate; D006631:Amine Oxidase (Copper-Containing); D000410:Alanine Transaminase; D011736:Pyridoxine