[Antigenic study of the differentiation of the human kidney using monoclonal antibodies].
The production of monoclonal antibodies against human embryonic renal cells allowed to display on the adult human kidney some antigens typical of certain structures or tissues: the proximal convoluted tubule for EG 9-11 and EG 19-6 monoclonal antibodies, the glomerular basement membrane for EG 14-1, the urothelium for EE 24-6, the connective tissue for EK 8-1 and EK 17-1 and probably the capsular and tubular basement membranes for EK 8-1. Simultaneously, we could follow the spatial and temporal repartition of the antigens during the renal development. One of them (EI 16-1) seemed to disappear in the adult and might correspond to a foetal type-antigen.
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis*; D001485:Basement Membrane / Q000166:cytology; D002454:Cell Differentiation; D002478:Cells, Cultured; D004847:Epithelial Cells; D005260:Female; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000196:embryology*; D007678:Kidney Glomerulus / Q000166:cytology / Q000196:embryology; D007687:Kidney Tubules, Proximal / Q000166:cytology / Q000196:embryology; D011247:Pregnancy
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface
Etude antigénique de la différenciation du rein humain par des anticorps monoclonaux.