[Intraventricular administration of 6-hydroxydopamine and ascorbic acid changes 3H-GABA absorption by synaptic endings of the cerebral cortex of the rat].
Combined administration of 6-hydroxydopamine with ascorbic acid had no effect on 3H-GABA uptake in the rat cortical synaptosomes, whereas a significant increase of the latter was observed within 2 days after 6-hydroxydopamine alone. Ascorbic acid alone (20 micrograms in 20 microliter saline, bilaterally) significantly increased 3H-GABA uptake within 2 days and decreased it within 21 days. The data suggest that: catecholaminergic system may affect (directly or indirectly) cortical GABAergic neurons, and injection of ascorbic acid into lateral ventricles exerts an obvious effect on synaptosomal 3H-GABA uptake in the brain cortex.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D006892:Hydroxydopamines; D005680:gamma-Aminobutyric Acid; D016627:Oxidopamine; D001205:Ascorbic Acid
Vnutrizheludochkovoe vvedenie 6-oksidofamina i askorbinovoĭ kisloty izmeniaet pogloshchenie 3H-GAMK sinapticheskimi okonchaniiami kory mozga krys.