[Characteristics of the T-lymphocytes interacting with hematopoietic stem cells: the expression of Lyt-3 antigen].
The lymph node cells were treated with monoclonal anti-Lyt-3 antibodies (anti-Lyt-3) and complement. Their interaction with colony-forming units (CFU) of bone marrow was studied. Anti-Lyt-3 did not affect the activity of T-lymphocytes, which changed the pattern of syngenic CFU differentiation in spleen of irradiated mice. On the contrary, the activity of T-lymphocytes, which inactivated proliferation and differentiation of non-syngenic CFU in spleen, was decreased. In the peritoneal cavity of irradiated mice antibodies did not affect the activity of T-lymphocytes which suppressed the colony-formation of non-syngenic stem cells and switched off the activity of T-lymphocytes that stimulated syngenic CFU colony-formation. The subpopulation characteristics of regulatory and effector T-cells has been analysed.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte; D000950:Antigens, Ly / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology / Q000528:radiation effects; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation; D003114:Colony-Forming Units Assay; D003165:Complement System Proteins / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000276:immunology* / Q000528:radiation effects; D007518:Isoantibodies / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology / Q000528:radiation effects / Q000637:transplantation; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000950:Antigens, Ly; D000954:Antigens, Surface; D007518:Isoantibodies; C029805:Lyt antibodies; D003165:Complement System Proteins
Kharakteristika T-limfotsitov, vzaimodeĭstvuiushchikh s krovetvornymi stvolovymi kletkami: ékspressiia antigena Lyt-3.