[Characteristics of the inhibition of thymus endocrine function and synthesis of substances with thymosin-like activity caused by thymostimulin and splenin during DMBA-induced mammary gland carcinogenesis in rats].
The contents of thymic hormones and endogenous substances with thymosin-like activity (TLA) was studied under conditions of administering thymostimulin and splenin during DMBA-induced carcinogenesis in rat mammary glands. It has been established that during latent carcinogenesis there is an inhibition of thymic endocrine function which persists in tumour-bearing animals. Injections of thymostimulin and splenin induce synthesis of substances with TLA, accompanied by an inhibition of blastoma development.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D051381:Rats; D013946:Thymopoietins / Q000494:pharmacology*; D013947:Thymosin / Q000096:biosynthesis*; D013949:Thymus Extracts / Q000494:pharmacology*; D013950:Thymus Gland / Q000378:metabolism / Q000503:physiopathology*; D013951:Thymus Hormones / Q000097:blood / Q000494:pharmacology*
D013946:Thymopoietins; D013949:Thymus Extracts; D013951:Thymus Hormones; C031407:thymostimulin; D015127:9,10-Dimethyl-1,2-benzanthracene; D013947:Thymosin; C032841:thymopoietin III
Osobennosti ugneteniia éndokrinnoĭ funktsii timusa i sinteza veshchestv s timozinpodobnoĭ aktivnost'iu, vyzyvaemoĭ timostimulinom i spleninom, pri DMBA-indutsirovannom kantserogeneze molochnykh zhelez u krys.