Inhibition of soybean lipoxygenase-1 by 10-butyryl substituted 1,8-dihydroxy-9-anthrone (butantrone).
10-Butyryl substituted 1,8-dihydroxyanthrone (butantrone) inhibited soybean lipoxygenase-1 irreversibly and more efficiently than its parent compound 1,8-dihydroxyanthrone (dithranol, anthralin) (IC50 values 0.090 mM and 1.1 mM, respectively). Intact butantrone rather than its hydrolysis product was the primary effector and the 10-butyryl moiety its site specific probe, probably directing the inhibitor to the proximity of the binding site of the lipid substrate/product.
D000873:Anthracenes / Q000494:pharmacology*; D000875:Anthralin / Q000031:analogs & derivatives / Q000494:pharmacology*; D001665:Binding Sites; D016859:Lipoxygenase Inhibitors; D013025:Glycine max / Q000201:enzymology*; D013329:Structure-Activity Relationship
D000873:Anthracenes; D016859:Lipoxygenase Inhibitors; C038464:butantrone; D000875:Anthralin