Spontaneous and graft-induced behavioral recovery after 6-hydroxydopamine lesion of the nucleus accumbens in the rat.
In the present study the long-term evolution of behavioral deficits following a local lesion of the dopaminergic innervation of the nucleus accumbens with 6-hydroxydopamine (6-OHDA) was compared in two groups of rats: lesioned animals and animals bearing a dopaminergic implant in the nucleus accumbens. Lesioned animals gradually recovered on various behavioral tests (amphetamine-induced locomotion, exploration, hoarding) and were indistinguishable from the control group on most parameters by 10 months postlesion. The deficits were, however, reinstated by a second intra-accumbens 6-OHDA lesion, a finding which suggests a role for dopaminergic reinnervation in the observed recovery. Conversely, grafted animals still displayed marked deficits even 10 months after grafting, although the lesioned areas were well reinnervated by the graft. These results indicate that the graft, while being unable on its own to compensate for part of the deficits, can nevertheless impair and compete with endogenous processes leading to behavioral recovery following a local lesion.
D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000628:therapy; D003342:Corpus Striatum; D004298:Dopamine / Q000502:physiology*; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology*; D008636:Mesencephalon / Q000637:transplantation*; D009714:Nucleus Accumbens; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D012075:Remission, Spontaneous; D012686:Septal Nuclei; D013378:Substantia Nigra
D006892:Hydroxydopamines; D016627:Oxidopamine; D004298:Dopamine