Testicular LH receptors and circulating hormone levels in three mouse models for inherited diseases (Tfm/y, lit/lit and hyt/hyt).
In mice with testicular feminization (Tfm/y), the concentration of LH receptors (LH-R) in the testes was greatly elevated, when compared to their normal controls (Ta/y). The administration of hCG caused, 24 hours later, a much greater decrease in the number of testicular LH-R in Tfm/y than in Ta/y mice. However, whereas in Ta/y mice, the decrease in LH-R was accompanied by a greater than 20 fold increase in plasma testosterone (T) levels, the same dose of hCG failed to alter plasma T levels in Tfm/y mice. Tfm/y mice were also characterized by significantly elevated circulating LH, FSH and PRL levels. Administration of hCG decreased testicular LH-R concentration in little (lit/lit) mice, whereas it had no effect in hypothyroid (hyt/hyt) and normal mice. Treatment with hCG elevated plasma T levels in all animals, but this increase was smaller in lit/lit than in Lit/- mice, while being greater in hyt/hyt than in Hyt/- mice. The present results suggest that the Tfm locus in the mouse is involved in the regulation of testicular LH-R. The only effect of GH deficiency on the parameters studied is on hCG-stimulated testicular steroidogenesis. The lack of negative autoregulation of LH-R by hCG in hyt/hyt mice may indicate a more active testicular LH-R metabolism, perhaps as a consequence of the chronic elevation of plasma TSH levels.
D013734:Androgen-Insensitivity Syndrome / Q000097:blood*; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004195:Disease Models, Animal; D004393:Dwarfism, Pituitary / Q000378:metabolism; D005640:Follicle Stimulating Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D007037:Hypothyroidism / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains / Q000378:metabolism*; D011388:Prolactin / Q000097:blood; D011974:Receptors, LH / Q000378:metabolism*; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000097:blood
D006063:Chorionic Gonadotropin; D006728:Hormones; D011974:Receptors, LH; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone