title: Failure of GABAergic inhibition: a key to local and global seizures.
abstract: Current working models of nervous system function based on many experimental observations are presented, often supported by extensive immunocytochemical findings, and partly by extrapolation of such findings into reasonable potentialities. Particular emphasis is placed on consideration of the roles of inhibitory GABAergic neurons in normal and abnormal information processing in the CNS.
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000502:physiology; D002540:Cerebral Cortex / Q000503:physiopathology; D004702:Endocrine Glands / Q000502:physiology; D004828:Epilepsies, Partial / Q000503:physiopathology; D006624:Hippocampus / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D008959:Models, Neurological; D009411:Nerve Endings / Q000502:physiology; D009424:Nervous System Physiological Phenomena; D009433:Neural Inhibition; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology; D012640:Seizures / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D005680:gamma-Aminobutyric Acid