Covalent binding of ethylated analogs of 7,12-dimethylbenz[a]anthracene to the DNA of mouse embryo fibroblast 10T1/2 cells.
The carcinogenicity of a number of ethylated analogs of 7,12-dimethyl-benz[a]anthracene (DMBA) has been previously studied. The covalent binding of these compounds to mouse embryo fibroblast 10T1/2 cell DNA expressed as adducts/10(6) bases, paralleled the original carcinogenicity studies and in decreasing order of potency were DMBA, 7-ethyl-12-methylbenz[a]anthracene (7-Et,12-MeBA), 7-methyl-12-ethylbenz[a]anthracene (7-Me,12-Et), and 7,12-diethylbenz[a]anthracene (7,12-DEBA). The results demonstrate that a major determinant of the carcinogenicity of these compounds relates to their ability to bind to DNA.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D002460:Cell Line; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage; D051379:Mice; D013329:Structure-Activity Relationship
D015127:9,10-Dimethyl-1,2-benzanthracene; D004247:DNA