title: Hardness changes and mineral loss in enamel during the intra oral cariogenicity test in the presence of 0.125% EHDP with or without 0.1% F-.
abstract: The effects of a high EHDP concentration (0.125%) were measured under Intra Oral Cariogenicity Test (ICT) conditions in the presence or absence of F- (0.1%). EHDP as well as EHDP supplemented with F- inhibited the softening of enamel slabs to a similar extent as measured by microhardness. Measurements of the calcium and phosphate levels as a function of depth showed that the addition of F- to the EHDP solution further decreased mineral loss in the deeper layers. The results suggest that the inhibition of demineralization of the enamel by EHDP and F- is due to inhibition of acid production by microorganisms.
mesh_terms: D002118:Calcium / Q000032:analysis; D002128:Calcium Metabolism Disorders / Q000378:metabolism*; D003649:Decalcification, Pathologic / Q000175:diagnosis / Q000378:metabolism*; D003733:Dental Caries Susceptibility; D003743:Dental Enamel / Q000032:analysis* / Q000187:drug effects; D003747:Dental Enamel Solubility / Q000187:drug effects*; D012968:Etidronic Acid / Q000032:analysis* / Q000494:pharmacology; D005459:Fluorides; D006244:Hardness; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009055:Mouth / Q000382:microbiology; D010710:Phosphates / Q000032:analysis
chemical_list: D010710:Phosphates; D012968:Etidronic Acid; D005459:Fluorides; D002118:Calcium