Calcinosis at the site of leakage from extravasation of calcium disodium edetate intravenous chelator therapy in a child with lead poisoning.
Painful calcinosis appeared at the wrist of an eight-year-old girl with lead poisoning. Careful history revealed that calcification occurred at the site of previous extravasation of calcium disodium edetate (EDTA) used in chelation therapy. Light microscopic, ultrastructural, electron activation, and X-ray diffraction studies demonstrated apatites with some suggestion of an admixture of octacalcium phosphate.
D002114:Calcinosis / Q000139:chemically induced* / Q000473:pathology; D002118:Calcium / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D004492:Edetic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007855:Lead Poisoning / Q000188:drug therapy*
D004492:Edetic Acid; D002118:Calcium