Observations on the clinical assessment of patients with motor neuron disease. Experience with a TRH analogue.
The need for improved assessment techniques in order to monitor the action of substances active in upper and lower motor neuron systems in motor neuron disease is discussed. A long-acting TRH analogue is shown to have detectable acute effects on bulbar symptoms, particularly speech, tone, fasciculations, and muscle force. Endocrine surveillance is essential in studies with TRH and analogues.
D002986:Clinical Trials as Topic; D006801:Humans; D009046:Motor Neurons; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects / Q000503:physiopathology; D009468:Neuromuscular Diseases / Q000188:drug therapy* / Q000503:physiopathology; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D013060:Speech / Q000187:drug effects / Q000502:physiology; D013961:Thyroid Gland / Q000187:drug effects / Q000503:physiopathology; D013972:Thyrotropin / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
D013973:Thyrotropin-Releasing Hormone; C027979:L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide; D013972:Thyrotropin; D011761:Pyrrolidonecarboxylic Acid