[Effects of loperamide on the fecal flora in children in severe diarrheas].
Loperamide has been recently indicated in the management of infants with severe protracted diarrhea. The purpose of this study was to determine the effect of loperamide on fecal flora in severe protracted diarrheas. 19 children aged 1 to 36 months, with severe protracted diarrhea were studied: 14 received loperamide (0.5 mg/kg/d) and 5 were without loperamide treatment. Criteria analysed were: clinical tolerance (vomiting and abdominal distention); efficacy (number of stools, transit time and Na+/K+ in stools) and effect on fecal flora, with differential qualitative and quantitative analysis method (complete identification and counts of aerobic and strict anaerobic bacteria in fresh fecal samples before and 4 to 8 days after the beginning of loperamide). Parenteral and/or oral alimentation remain constant during the study. Results show a rapid (24 h) efficacy in 9/14. Although important changes in specific fecal flora counts was noticed for streptococcus D and Proteus as compared to five controls, no bacterial overgrowth appeared or was increased during loperamide treatment.
D002675:Child, Preschool; D003968:Diarrhea, Infantile / Q000382:microbiology*; D004573:Electrolytes / Q000032:analysis; D004755:Enterobacteriaceae / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005243:Feces / Q000382:microbiology*; D006801:Humans; D007223:Infant; D008139:Loperamide / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D011549:Pseudomonas / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects
D004573:Electrolytes; D010880:Piperidines; D008139:Loperamide
Effets de la lopéramide sur la flore fécale de l'enfant au cours des diarrhées graves sévéres.