Perspective on carbamazepine-induced water intoxication: reversal by demeclocycline.
Carbamazepine (CBZ)-induced water intoxication occasionally limits its usefulness in refractory seizures and trigeminal neuralgia. Fluid restriction, CBZ dose reduction, or concomitant phenytoin therapy may be impractical or ineffective. Demeclocycline (7-chloro-6 demethyl tetracycline) (DMC) corrected the CBZ-induced water intoxication in a 51-year-old man with refractory complex partial seizures and a normal antidiuretic hormone (ADH) level. DMC inhibits ADH-sensitive adenylate cyclase activity in the renal collecting duct and may be useful in correcting the ADH-like or renal antidiuretic effect of CBZ.
D002220:Carbamazepine / Q000009:adverse effects*; D003707:Demeclocycline / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014667:Vasopressins / Q000378:metabolism; D014869:Water Intoxication / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism
D014667:Vasopressins; D002220:Carbamazepine; D003707:Demeclocycline