[Effect of synthetic analogs of enkephalins, morphine and their antagonists on the course of experimental traumatic shock].
Effects of naloxone, nalorphine, thyroliberin, morphine and two analogues of enkephalins (FK 33-824 and Tyr-D-Ala-Gly-Phe(NO2)-NH2) on the course of traumatic shock were studied in experiments on rabbits. It was found that antagonists of opioid peptides aggravated the course of traumatic shock and morphine and synthetic analogues of enkephalins exerted positive effects during its treatment. Endogenous opioid peptides are suggested to play the protective role in experimental traumatic shock.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004745:Enkephalins / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D008297:Male; D009022:Morphine Derivatives / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D009269:Nalorphine / Q000627:therapeutic use; D009270:Naloxone / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D011817:Rabbits; D012774:Shock, Traumatic / Q000188:drug therapy* / Q000503:physiopathology; D013973:Thyrotropin-Releasing Hormone / Q000627:therapeutic use
D004745:Enkephalins; D009022:Morphine Derivatives; D009292:Narcotic Antagonists; D009270:Naloxone; D013973:Thyrotropin-Releasing Hormone; D009269:Nalorphine
Vliianie sinteticheskikh analogov énkefalinov, morfina i ikh antagonistov na techenie éksperimental'nogo travmaticheskogo shoka.