[Effects of injecting 6-hydroxydopamine into areas of the nigro-striatal (A9) and mesolimbic (A10) dopaminergic systems on the elaboration of a conditioned feeding reflex in the rat].
Wistar male rats were bilaterally injected under nembutal anaesthesia (40 mg/kg) with 16 mcg of 6-hydroxidopamine (6-HODA) in the A9 and A10 areas during petilil action and without it. In a month, operated, pseudo-operated and control rats were conditioned to a food-procuring reaction in a T-maze. Injection of 6-HODA both to A9 and A10 areas without petilil made the learning impossible. Fluorescence was lowered both in dopamine and noradrenaline containing brain nuclei. Rats injected with 6-HODA in A9 against the background of petilil did not learn. After 6-HODA injections in A10 in these conditions, the learning worsened but was possible. Fluorescence of dopamine after 6-HODA injection in A9 during petilil action was reduced in the caudate nucleus, and after injection in A10--in n. accumbens and the olfactory tubercle. The obtained results point to a significant role of predominantly nigro-striate system in performance of alimentary conditioned reactions in the T-maze.
D000818:Animals; D001931:Brain Mapping; D003214:Conditioning, Classical / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects*; D004298:Dopamine / Q000502:physiology*; D005247:Feeding Behavior / Q000187:drug effects; D006892:Hydroxydopamines / Q000494:pharmacology*; D008032:Limbic System / Q000187:drug effects*; D008297:Male; D008636:Mesencephalon / Q000187:drug effects*; D009434:Neural Pathways / Q000187:drug effects; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects
D006892:Hydroxydopamines; D016627:Oxidopamine; D004298:Dopamine
Effekty vvedeniia 6-gidroksidofamina v oblastiakh nigro-striarnoĭ (A9) i mezolimbicheskoĭ (A10) dofaminergicheskikh sistem na vyrabotku pishchevoĭ uslovnoĭ reaktsii u krys.