Experimental research of the influence of the body electrolytic composition on the toxic effect of morphine.
The ionic composition of the internal environment influences the toxic effect of morphine. LD50 for morphine and thiopental was tested in 3 lots of mice: with sodium depletion, with sodium load, and with normal sodium content in the food. LD50 for morphine was clearly influenced by the treatment received by the animals. Since such differences could not be found with thiopental, we consider that the ionic composition of the internal environment could modify the steric conformation of the receptor-macromolecule for opioids.
D000818:Animals; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009020:Morphine / Q000633:toxicity*; D012964:Sodium / Q000378:metabolism*; D013874:Thiopental / Q000633:toxicity
D009020:Morphine; D012964:Sodium; D013874:Thiopental