Inhibition of bone cell metabolism increases strontium-85 uptake.
Experiments have been performed on the canine tibia to investigate whether perturbation of the energy metabolism of bone cells can influence the short-term exchange of bone mineral. Simultaneous injection of three radioactive tracers, 125I-albumin, 85Sr, and 86Rb, into the tibial nutrient artery was followed immediately by measurement of the concentration of these tracers in the venous outflow from the bone for a period of 5 minutes. This procedure was performed before and after the injection of potassium cyanide into the bone. From the measured concentrations, extraction ratios for 85Sr and 86Rb with respect to 125I-albumin were calculated. It was found that net extraction after 5 minutes of 85Sr was significantly increased. This result indicates that efflux of ions from exchangeable mineral is dependent to a significant extent on the metabolic activity of bone cells.
D000418:Albumins / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001842:Bone and Bones / Q000378:metabolism*; D003864:Depression, Chemical; D004285:Dogs; D004734:Energy Metabolism / Q000187:drug effects; D011190:Potassium Cyanide / Q000494:pharmacology; D012413:Rubidium / Q000378:metabolism; D013324:Strontium / Q000378:metabolism*
D000418:Albumins; D012413:Rubidium; D011190:Potassium Cyanide; D013324:Strontium