Genetic control of the production of anti-thyroid hormone antibodies in mice immunized with human thyroglobulin.
Various strains of mice with different H-2 and Igh-I allotypes were immunized with human thyroglobulin (HTg) and genetic control of the production of anti-thyroid hormone antibodies was examined. Anti-HTg antisera obtained from different strains of mice were examined for the presence of anti-thyroid hormone antibodies. At least one Ir-gene which controls the production of anti-T4 antibodies by immunization with HTg was identified in the I-A subregion. The presence of Ir-genes outside the H-2 was also suspected. Concerning the production of anti-T3 antibodies, only three strains (B10.A, C3H.SW, BALB/cJ) were high responders and therefore we were unable to identify the Ir-gene for them. These results indicate the presence of Ir-gene which controls the immune response in mice against thyroid hormone and suggest that the anti-thyroid hormone antibodies observed in various thyroidal and non-thyroidal disorders could be anti-HTg antibodies. The significance of genetic control of the production of anti-thyroid hormone antibodies in mice immunized with HTg is discussed.
D000818:Animals; D000906:Antibodies / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D000917:Antibody Formation; D005260:Female; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000276:immunology; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000145:classification / Q000235:genetics; D008815:Mice, Inbred Strains / Q000235:genetics / Q000276:immunology*; D013954:Thyroglobulin / Q000008:administration & dosage / Q000276:immunology*; D013963:Thyroid Hormones / Q000276:immunology*; D013974:Thyroxine / Q000276:immunology; D014284:Triiodothyronine / Q000276:immunology
D000906:Antibodies; D006183:H-2 Antigens; D007126:Immunoglobulin Allotypes; D013963:Thyroid Hormones; D014284:Triiodothyronine; D013954:Thyroglobulin; D013974:Thyroxine