Leu-7 immunoreactivity in human, monkey, and pig bronchopulmonary neuroepithelial bodies and neuroendocrine cells.
Anti-Leu 7 is a monoclonal antibody recognizing a surface antigen on human natural killer cells. By applying the indirect immunoperoxidase method, we demonstrated Leu-7 immunoreactivity in the cytoplasm of neuroepithelial bodies (NEB) and neuroendocrine cells (NEC) of human, monkey, and pig respiratory mucosa. In addition, the anti-Leu-7 monoclonal antibody stained the myelin sheaths of nerve fibers in all tissues investigated. Our findings support the hypothesis that shared antigens exist between the nervous, endocrine, and immune systems.
D000818:Animals; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D000954:Antigens, Surface / Q000032:analysis*; D001980:Bronchi / Q000166:cytology / Q000276:immunology; D003594:Cytoplasmic Granules / Q000032:analysis; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D005260:Female; D000882:Haplorhini; D006801:Humans; D007124:Immunoenzyme Techniques; D008168:Lung / Q000166:cytology* / Q000276:immunology; D008297:Male; D009186:Myelin Sheath / Q000166:cytology / Q000276:immunology; D009475:Neurons, Afferent / Q000166:cytology* / Q000276:immunology; D009490:Neurosecretory Systems / Q000166:cytology*; D011650:Pulmonary Alveoli / Q000166:cytology / Q000276:immunology; D011817:Rabbits; D051381:Rats; D013552:Swine
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface