Ultrasonic radiation induced lipid peroxidation in liposomal membrane.
Ultrasonic radiation produced a dose dependent linear increase in lipid peroxidation (MDA formation) in the liposomal membrane. The yield of MDA was significantly inhibited by butylated hydroxytoluene (BHT), the antioxidant, sodium formate, the OH. radical scavenger, and EDTA, the metal ion chelator. Ascorbic acid at low concentration increased the ultrasonic induced MDA formation while high concentrations inhibited lipid peroxidation. A mechanism of ultrasound induced lipid peroxidation is suggested.
D001205:Ascorbic Acid / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D005561:Formates / Q000494:pharmacology; D005609:Free Radicals; D008054:Lipid Peroxides / Q000528:radiation effects*; D008081:Liposomes / Q000528:radiation effects*; D008315:Malondialdehyde / Q000528:radiation effects; D014465:Ultrasonics
D005561:Formates; D005609:Free Radicals; D008054:Lipid Peroxides; D008081:Liposomes; C030544:formic acid; D002084:Butylated Hydroxytoluene; D008315:Malondialdehyde; D004492:Edetic Acid; D001205:Ascorbic Acid