Parenteral nutrition of injured patients.
Injured patients treated with fructose 1,6-diphosphate (1 millimole of phosphate per kilogram per day) together with parenteral nutrition had a better nitrogen balance than patients treated with isocaloric nutrition and an inorganic source of phosphate. Excretion of 3-methylhystidine was similar while tyrosine and alanine output from the extremities was lower in the group of patients given fructose 1,6-diphosphate. The data indicates that the protein sparing action of fructose 1,6-diphosphate is exerted through an increased protein synthesis.
D000007:Abdominal Injuries / Q000628:therapy; D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000097:blood; D004341:Drug Evaluation; D005260:Female; D005635:Fructosediphosphates / Q000378:metabolism / Q000627:therapeutic use*; D006598:Hexosediphosphates / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008762:Methylhistidines / Q000652:urine; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism*; D010289:Parenteral Nutrition, Total; D010710:Phosphates / Q000378:metabolism / Q000627:therapeutic use; D011188:Potassium / Q000378:metabolism / Q000627:therapeutic use; D017680:Potassium Compounds; D011897:Random Allocation; D014947:Wounds and Injuries / Q000628:therapy*
D000596:Amino Acids; D005635:Fructosediphosphates; D006598:Hexosediphosphates; D008762:Methylhistidines; D010710:Phosphates; D017680:Potassium Compounds; C013216:potassium phosphate; C029063:fructose-1,6-diphosphate; C028118:3-methylhistidine; D009584:Nitrogen; D011188:Potassium