Testicular vascular resistance in the rat after intratesticular injection of an LRH-agonist.
Testicular vascular resistance (TVR) was estimated 1, 2, 4 and 8 h after unilateral intratesticular injection of 1 or 10 ng of an LRH-agonist (A). The lower dose had no effect on plasma levels of testosterone or LH, but there was a significant increase in TVR 2 h after injection when compared to the vehicle-injected contralateral testis. Injection of 10 ng LRH-A induced an increase in plasma levels of LH at 1 and 2 h after treatment and in the plasma levels of testosterone at 1, 2 and 4 h. In the same rats there was a decrease in TVR at 2, 4 and 8 h after LRH-A treatment compared to the contralateral testis. It is concluded that LRH-A can have both stimulatory and inhibitory effects on TVR in the rat and that the direction of this effect may be related to the ambient level of LH.
D000818:Animals; D002064:Buserelin / Q000494:pharmacology*; D004822:Epididymis / Q000098:blood supply; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013737:Testis / Q000098:blood supply*; D013739:Testosterone / Q000097:blood; D014655:Vascular Resistance / Q000187:drug effects*
D013739:Testosterone; D007986:Luteinizing Hormone; D002064:Buserelin