[M monoclonal macroglobulinemia induced in BALB/C mice. Effect on blood cholesterol and its significance].
BALB/C mice have been inoculated with a monoclonal IgM secreting hybridoma and have developed an hypocholesterolemia strongly dependent of the hypermacroglobulinemia M obtained (P less than 0.001). Cholesterolegram shows cholesterol is carried on the monoclonal IgM fraction. This result has been established in comparison with a lot of mice treated with the same no secreting hybridoma and a lot of untreated-mice, in these cases cholesterolemia is not modified. The whole aminoacids sequence of this IgM being nearly achieved, it is thinked of check the hypocholesterolemic activity of several parts of this immunoglobulin.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001798:Blood Proteins / Q000032:analysis; D002784:Cholesterol / Q000097:blood*; D004195:Disease Models, Animal; D006825:Hybridomas / Q000276:immunology; D007075:Immunoglobulin M / Q000378:metabolism*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008258:Waldenstrom Macroglobulinemia / Q000097:blood*
D000911:Antibodies, Monoclonal; D001798:Blood Proteins; D007075:Immunoglobulin M; D008074:Lipoproteins; D002784:Cholesterol
Macroglobulinémie M monoclonale provoquée chez la souris BALB/C. Incidence sur la cholestérolémie et intérêt.