[Acebutolol and cerebral blood flow of the moderately hypertensive aged subject].
In 17 moderate hypertensive patients (mean age = 67 +/- 8.8) the effects of a chronic oral administration of the beta blocking agent acebutolol on regional cerebral blood flow (rCBF) was studied using the non invasive 133 Xenon inhalation technique. The results was compared to the rCBF obtained in an age matched normal control group. Our study shows that during long term therapy low doses of acebutolol (200 mg/daily) the rCBF is unaffected by a decrease (20 mmHg) of the mean arterial blood pressure. The relative hypofrontality of the elderly hypertensive patients leads to be corrected by acebutolol.
D000070:Acebutolol / Q000009:adverse effects*; D000368:Aged; D002561:Cerebrovascular Disorders / Q000139:chemically induced*; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D000070:Acebutolol
Acébutolol et débit sanguin cérébral du sujet âgé moyennement hypertendu.