Effects of arecoline and pilocarpine on learning ability in marmosets pretreated with hemicholinium-3.
Common marmosets (Callithrix jacchus) were trained to perform serial reversal position discrimination tasks in a Wisconsin General Test Apparatus. Intraventricular injection of hemicholinium-3 4 h before testing resulted in a profound impairment of position discrimination learning which could be overcome by the intramuscular administration of low doses of the muscarinic agonists, arecoline or pilocarpine.
D000818:Animals; D001115:Arecoline / Q000008:administration & dosage / Q000494:pharmacology*; D002143:Callitrichinae / Q000502:physiology*; D005260:Female; D006426:Hemicholinium 3 / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007858:Learning / Q000187:drug effects*; D008297:Male; D010862:Pilocarpine / Q000008:administration & dosage / Q000494:pharmacology*
D010862:Pilocarpine; D006426:Hemicholinium 3; D001115:Arecoline