Parathyroidectomy increases peripheral vascular responsiveness to exogenous noradrenaline in the uraemic rat.
The effect of surgical parathyroidectomy and/or cyclo-oxygenase inhibition on noradrenaline-induced blood pressure (BP) responses were investigated in a rat model of chronic uraemia. The blood pressure responses to noradrenaline were significantly lower in uraemic rats when compared with the responses of non-uraemic animals. Blood pressure responses of previously parathyroidectomized uraemic rats were significantly greater than sham-operated uraemic rats, as were the responses of uraemic rats pretreated with the cyclo-oxygenase inhibitor, indomethacin. Pretreatment of uraemic rats with both indomethacin and parathyroidectomy improved blood pressure responses to a degree equal to either manoeuvre alone, but did not exhibit an additive effect. These data suggest a role for parathyroid hormone and prostaglandins in the pathogenesis of the diminished noradrenaline responsiveness in uraemia, and suggest a common mechanism.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002908:Chronic Disease; D004195:Disease Models, Animal; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010280:Parathyroid Glands / Q000601:surgery*; D051381:Rats; D011919:Rats, Inbred Strains; D014511:Uremia / Q000503:physiopathology*
D009638:Norepinephrine; D007213:Indomethacin