[Intravector anti-Plasmodium activity of a pyrethrinoid: deltamethrin].
In vitro tests, deltamethrin reduced the parasitemic index of Plasmodium falciparum on human red blood corpuscles. In vivo tests, at sublethal doses, deltamethrin limited the development of the sporogonic cycle of Plasmodium yoelii yoelii in Anopheles stephensi. This novel type of antiplasmodic activity involve an intravectorial route and gives an explanation about surprising antimalaria effects observed several months after treatment.
D000818:Animals; D000852:Anopheles / Q000469:parasitology*; D000962:Antimalarials; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D007306:Insecticides / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D009570:Nitriles; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D011722:Pyrethrins / Q000494:pharmacology*
D000962:Antimalarials; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin
Activité antiplasmodique intravectorielle d'un pyréthrinoide: la deltaméthrine.