Studies on the tolerance of medium chain triglycerides in dogs.
Two groups of five conscious dogs received total parenteral nutrition (about 100 kcal/kg body weight per 24 hr) continuously for 96 hr (0.28 g triglycerides/kg body weight per hr, constituting more than 55% of the energy supply). The only difference between the two groups was the nature of the 20% lipid emulsion. In one group, this emulsion contained only long-chain triglycerides (LCTs), and in the other it contained a mixture (vol/vol) of medium chain triglycerides (MCTs) and LCTs. MCTs thus were given in an amount of about 30% of the total energy supplied. During infusion with the MCT/LCT mixture, C8, C10, and C12 fatty acids appeared in the total plasma fatty acids. When the infusion was stopped, the medium-chain fatty acids disappeared; those with shorter chains did so more rapidly. The plasma triglyceride clearance was faster for the MCT/LCT mixture than for the LCTs, whereas phospholipid and cholesterol clearance seemed slower for the MCT/LCT mixture. With this mixture, there was a slight increase in the plasma concentrations of ketone bodies, lactate, and pyruvate, and a slight decrease in plasma glucose. The MCT/LCT mixture was well tolerated, causing no discernible problems, and, in particular, no signs of narcosis or encephalopathy.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage; D004285:Dogs; D004655:Emulsions; D004734:Energy Metabolism; D005227:Fatty Acids / Q000097:blood; D007328:Insulin / Q000097:blood; D007657:Ketone Bodies / Q000097:blood; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D010289:Parenteral Nutrition, Total; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D014280:Triglycerides / Q000008:administration & dosage* / Q000097:blood
D001786:Blood Glucose; D004041:Dietary Fats; D004655:Emulsions; D005227:Fatty Acids; D007328:Insulin; D007657:Ketone Bodies; D007773:Lactates; D011773:Pyruvates; D014280:Triglycerides; D019344:Lactic Acid; D019289:Pyruvic Acid