title: Suppression of hemoglobin H in disorders of iron metabolism.
abstract: Disorders of iron metabolism affect the expression of hemoglobin H in hemoglobin H disease. Two cases of iron deficiency with reduced synthesis of hemoglobin H are described in the literature. We report two more cases, one with anemia of chronic disease and another with alcoholic sideroblastic anemia where the hemoglobin H was not detected at presentation and appeared after treatment of the underlying disorder. The pathogenesis of suppression of hemoglobin H is discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking; D000747:Anemia, Hypochromic / Q000097:blood* / Q000175:diagnosis; D000756:Anemia, Sideroblastic / Q000097:blood* / Q000175:diagnosis; D002908:Chronic Disease; D005260:Female; D006447:Hemoglobin H / Q000032:analysis / Q000378:metabolism*; D006455:Hemoglobins, Abnormal / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000378:metabolism; D000090463:Iron Deficiencies
chemical_list: D006455:Hemoglobins, Abnormal; D006447:Hemoglobin H; D007501:Iron