Changes of free histones in chick testicular and ovarian cells after embryonic and/or neonatal treatment with diethylstilbestrol (DES) or allyloestrenol (AE).
DES and AE when injected into the yolk sac of chick embryos on the 9th day of incubation decreased the neonatal weight of the testis and the PMB-reaction of spermatogonia whereas they increased the neonatal weight and granulosa cell PMB-reaction of the ovary. In the ovary, embryonic treatment increased the efficiency of post-hatching hormone treatments.
D000367:Age Factors; D000500:Allylestrenol / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004963:Estrenes / Q000494:pharmacology*; D005260:Female; D006107:Granulosa Cells / Q000166:cytology / Q000378:metabolism; D006657:Histones / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013093:Spermatogonia / Q000166:cytology / Q000378:metabolism; D013737:Testis / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D015017:Yolk Sac / Q000378:metabolism
D004963:Estrenes; D006657:Histones; D004054:Diethylstilbestrol; D000500:Allylestrenol