Double-blind study of glycerol vs glucose in parenteral nutrition of postsurgical insulin-treated diabetic patients.
Twenty-five insulin-treated diabetic patients were randomly assigned postoperatively to 5 days of intravenous infusions of ProcalAmine (3% amino acids, 3% glycerol, and electrolytes) or FreAmineIII + dextrose and electrolytes. The solutions were given isocalorically and isonitrogenously. Insulin was adjusted to keep glycemia at the level of 150-200 mg/dl. The ProcalAmine group by the 5th day had plasma glucose of 158 +/- 25 mg/dl and required 1.20 +/- 0.10 U/hr insulin. The FreAmine + dextrose group had plasma glucose of 169 +/- 53 mg/dl and required 2.28 +/- 0.13 U/hr. At all time points postsurgically, the ProcalAmine group required less insulin.
D000328:Adult; D000368:Aged; D000596:Amino Acids; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000628:therapy; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004311:Double-Blind Method; D004573:Electrolytes; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D005990:Glycerol / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D057947:Parenteral Nutrition Solutions; D011182:Postoperative Care; D011897:Random Allocation; D012996:Solutions
D000596:Amino Acids; D004040:Dietary Carbohydrates; D004573:Electrolytes; D057947:Parenteral Nutrition Solutions; D012996:Solutions; C545824:amino-acid, glucose, and electrolyte solution; C052903:ProcalAmine; D005947:Glucose; D005990:Glycerol