title: The relationship between pathology and resistance to reinfection with Schistosoma mansoni in mice: a causal mechanism of resistance in chronic infections.
abstract: The development of resistance in mice to reinfection with Schistosoma mansoni was recorded during an early chronic infection, and compared with hepatic portal pathological and vascular changes. The latter were assessed using a microsphere injection technique. The degree of acquired resistance was directly dependent on the patent worm burden and the time post-infection. Strong correlations were noted between the development of resistance and the appearance of parasite eggs in the lungs and spleens of infected hosts. Weaker associations were present between resistance and other aspects of the disease pathology, such as portal hypertension and organ weights. The appearance of injected microspheres in the lungs and spleens correlated well with the appearance of eggs in those organs and with the development of resistance. The levels of resistance had risen and microspheres were detected in the lungs, before the development of major extra-hepatic, porta-systemic collateral vessels. It is concluded that intra-hepatic vascular alterations may be a causal factor in the development of resistance, preventing the sequestration of migrating schistosomula in the liver. It is estimated that as much as 70-75% of the recorded resistance can be attributed to this immunologically non-specific mechanism.
mesh_terms: D000818:Animals; D002908:Chronic Disease; D006975:Hypertension, Portal / Q000473:pathology; D008099:Liver / Q000098:blood supply / Q000469:parasitology / Q000473:pathology*; D008168:Lung / Q000469:parasitology; D051379:Mice; D008863:Microspheres; D009929:Organ Size; D011168:Portal System / Q000473:pathology*; D012550:Schistosoma mansoni / Q000254:growth & development / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000469:parasitology / Q000473:pathology*; D013154:Spleen / Q000469:parasitology; D013997:Time Factors