title: [Results of long-term D-penicillamine therapy in chronic polyarthritis].
abstract: In 34 patients with severe rheumatoid arthritis the therapeutic efficacy of 600 mg/die of D-penicillamine was evaluated for five years. Patients were included in the study only if the duration of their disease exceeded 6 months (upper limit 12 months), and there was involvement of 6 or more joints and an elevated erythrocyte sedimentation rate (1 Hour values greater than or equal to 25 mm). In 9 patients (26%) a decline in the activity index could be observed, but 7 of these subjects had a deterioration of findings as assessed by x-ray. The increase of the activity index indicated no therapeutic benefit in 25 patients (74%), which could be confirmed in all subjects by x-ray.
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007596:Joints / Q000187:drug effects; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000627:therapeutic use*; D013583:Synovial Membrane / Q000187:drug effects
chemical_list: D010396:Penicillamine
vernacular_title: Ergebnisse der D-Penicillamin-Langzeittherapie bei chronischer Polyarthritis.