title: Endometrial effects of a continuous percutaneous oestrogen/low dose oral progestogen regimen for climacteric complaints.
abstract: Eleven post-menopausal women were followed up during continuous replacement therapy with percutaneous 17 beta-oestradiol, 1.5 mg, opposed by oral levo-norgestrel, 30 micrograms, daily. Endometrial biopsies were taken before and after 3 months of treatment. Conventional histopathological analyses and morphometric analyses of glandular epithelial nuclei revealed only slight proliferative activity and no secretory changes. The results indicate that endometrial proliferation during post-menopausal oestrogen replacement therapy can probably be prevented by the continuous addition of a very low dose of progestogen.
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D002455:Cell Division / Q000187:drug effects; D002979:Climacteric / Q000187:drug effects*; D004359:Drug Therapy, Combination; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D016912:Levonorgestrel; D008593:Menopause / Q000187:drug effects*; D009644:Norgestrel / Q000008:administration & dosage*
chemical_list: D009644:Norgestrel; D004958:Estradiol; D016912:Levonorgestrel