[Circulating immune complexes in patients with malignant neoplasms].
Circulating immune complexes were identified in 143 patients with malignant tumors (70--solid cancer, 37--acute leukemia, 21--chronic lympholeukemia and 15--myelomatosis) as well as in 64 patients with chronic inflammatory diseases. Immune complexes were detected in 40% with the aid of precipitation with polyethylene glycol alone and in 50%--by using it in combination with an anticomplementary method. Immune complexes occurred more often in acute myeloid leukemia (66%) than in pancreatic cancer (23%) or chronic lymphoid leukemia (29%). The immunoglobulin profile of complexes varied: in patients with pancreatic cancer, mainly IgM was found; in leukemic patients--different combinations of IgM, IgA and IgG. In the immune complexes of some patients with pancreatic disease, CEA and normal pancreatic antigens were detected.
D000936:Antigen-Antibody Complex / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D006801:Humans; D005779:Immunodiffusion; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007938:Leukemia / Q000276:immunology; D009101:Multiple Myeloma / Q000276:immunology; D009369:Neoplasms / Q000276:immunology*; D011863:Radioimmunoassay
D000936:Antigen-Antibody Complex; D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Tsirkuliruiushchie immunnye kompleksy u bol'nykh so zlokachestvennymi novoobrazovaniiami.