Photosensitization of membrane components.
The chemical mechanisms of the photosensitized peroxidation of unsaturated fatty acids and cholesterol are reviewed and the subsequent reactions of peroxide decomposition products with biological targets such as DNA and amino acids are analyzed. The importance of protein photooxidation and cross-linking in membrane function impairment is discussed.
D000588:Amines; D000596:Amino Acids; D000818:Animals; D002462:Cell Membrane / Q000528:radiation effects*; D002784:Cholesterol / Q000528:radiation effects; D004247:DNA / Q000528:radiation effects; D004910:Erythrocyte Membrane / Q000528:radiation effects; D005231:Fatty Acids, Unsaturated / Q000528:radiation effects; D005609:Free Radicals; D008027:Light; D008054:Lipid Peroxides; D008081:Liposomes; D008563:Membrane Lipids / Q000528:radiation effects; D008565:Membrane Proteins / Q000528:radiation effects; D008823:Micelles; D010084:Oxidation-Reduction; D010100:Oxygen; D010777:Photochemistry; D026082:Singlet Oxygen
D000588:Amines; D000596:Amino Acids; D005231:Fatty Acids, Unsaturated; D005609:Free Radicals; D008054:Lipid Peroxides; D008081:Liposomes; D008563:Membrane Lipids; D008565:Membrane Proteins; D008823:Micelles; D026082:Singlet Oxygen; D004247:DNA; D002784:Cholesterol; D010100:Oxygen