Transient response of pure red cell aplasia to anti-thymocyte globulin in a patient with T-cell chronic lymphocytic leukemia.
Pure red cell aplasia (PRCA) is an unusual complication of chronic lymphoproliferative disorders. A patient with T-cell chronic lymphocytic leukemia (T-CLL) had severe anemia and neutropenia. Initial in vitro studies demonstrated no evidence of T-cell suppression of erythropoiesis. Sequential bone marrow examinations demonstrated progressive red cell aplasia. In vitro studies showed that the T-cells from the patient suppressed allogeneic but not autologous BFU-E. Treatment with antithymocyte globulin (ATG) reduced circulating leukemic cells and produced a definite but transient improvement in erythropoiesis.
D000328:Adult; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D003114:Colony-Forming Units Assay; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications*; D008297:Male; D012010:Red-Cell Aplasia, Pure / Q000150:complications / Q000188:drug therapy*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000032:analysis / Q000276:immunology
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D000961:Antilymphocyte Serum