[Rioprostil 600 micrograms at night: marked inhibition of nocturnal intragastric acidity in man].
Antisecretory doses of prostaglandin analogues of the E1 and E2 series have been shown to promote peptic ulcer healing. In this double blind randomized cross-over study we investigated the effect of oral Rioprostil 300 micrograms b.i.d., 600 micrograms hs and placebo on 24 h intragastric H+ activity in 9 healthy male volunteers (age 20-37 years). 5-10 ml of gastric contents were aspirated hourly via a nasogastric tube. The pH of the samples was determined using a glass electrode . The results were expressed in terms of H+ activity (mmol/l). Night acidity (AUC/h, 2400-0800) is decreased by rioprostil in a dose related fashion (300 micrograms: 52%, 600 micrograms: 74%). The effect on day-time (0900-1800) H+ activity is much less. Rioprostil 300 micrograms given at breakfast reduce day-time acidity by 33%. Our results suggest that 600 micrograms Rioprostil in a single bedtime dose is effective in peptic ulcer treatment.
D000328:Adult; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005745:Gastric Acidity Determination; D006801:Humans; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology*; D011897:Random Allocation; D016630:Rioprostil
D000897:Anti-Ulcer Agents; D011458:Prostaglandins E; D016630:Rioprostil
Rioprostil 600 micrograms nocte: Ausgeprägte Hemmung der nächtlichen intragastralen Azidität des Menschen.