title: The significance of anti-c alloimmunization in pregnancy.
abstract: In an 8-year period, 177 of 280,000 pregnancies were complicated by maternal anti-c alloimmunization. Although there was one neonatal death associated with anti-c haemolytic disease of the newborn, only two infants were severely anaemic at birth. A total of 11 babies required exchange transfusion, but nine of these developed hyperbilirubinaemia alone. The remaining c positive infants were either unaffected or only mildly affected by erythroblastosis fetalis. A strategy for management of these pregnancies is outlined, and proposed methods of prevention and serological control are discussed.
mesh_terms: D001787:Blood Group Incompatibility / Q000276:immunology* / Q000628:therapy; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000276:immunology* / Q000517:prevention & control; D012204:Rh-Hr Blood-Group System
chemical_list: D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System; C051138:anti-c antibody