Sebaceous adenomas with associated epidermal hyperplasia and papilloma formation as a major type of tumor induced in mouse skin by high doses of carcinogens.
Application of a single high dose of 7,12-dimethylbenz[a]anthracene (DMBA, 1 mg) or N-nitrosomethylurea (NMU, 0.4 mg) to the ears of either athymic nu/nu or phenotypically normal nu/+ mice (BALB/c background) resulted in the appearance of cutaneous sebaceous adenomas as well as squamous cell tumors, both at the site of application and elsewhere. The incidence of sebaceous adenomas was 10-fold greater than that of squamous cell tumors after DMBA and 4-fold greater after NMU. A high proportion of these sebaceous tumors (69%) exhibited specifically-associated hyperplasia of the overlying epidermis. In 57 cases, a squamous cell papilloma had developed from the hyperplastic epidermis. These findings introduce the sebaceous gland as a potentially interesting new model for studies of carcinogen-target cell interaction in mouse skin.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000236:Adenoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced / Q000473:pathology; D004817:Epidermis / Q000473:pathology*; D006965:Hyperplasia; D051379:Mice; D008819:Mice, Nude; D010212:Papilloma / Q000139:chemically induced* / Q000473:pathology; D012626:Sebaceous Gland Neoplasms / Q000139:chemically induced* / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013755:Tetradecanoylphorbol Acetate
D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate