title: [A case of hypopharyngeal cancer responding to recombinant interferon-gamma (KW-2202)].
abstract: A 66-year-old woman with hypopharyngeal cancer was treated with recombinant interferon-gamma (KW-2202). r-IFN-gamma was administered at a dose of 1-8 X 10(6) U/body every day for six weeks by i.v. drip infusion. After the start of the therapy both the primary tumor and metastatic lymph nodes showed remarkable regression and PR was obtained. Observed side effects, which included fever and hepatic function disorder, were slight and transient. Immunological studies were also carried out on the patients and the results were reported. Further investigation will be necessary in order to confirm the efficacy of the drug and to compile data on immunological parameters.
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D007262:Infusions, Intravenous; D007371:Interferon-gamma / Q000008:administration & dosage / Q000627:therapeutic use*; D008207:Lymphatic Metastasis; D010610:Pharyngeal Neoplasms / Q000628:therapy*
chemical_list: D007371:Interferon-gamma