Inhibition of nocturnal gastric secretion by trimoprostil, a synthetic prostanoid.
Eleven healthy volunteers had nocturnal gastric secretion studied on three occasions to compare, in a randomized manner, the gastric inhibitory effects of two doses (1.5 and 3.0 mg) of trimoprostil with placebo. Nocturnal gastric secretion of acid was significantly inhibited for 7 hours with the higher dose of the drug, by a total of about 50 percent. The output of pepsin was also reduced, albeit not as markedly as acid, for the first 5 hours of the study. It is concluded that trimoprostil, in the doses used in the present study, is capable of reducing gastric secretion without producing side-effects.
D000328:Adult; D002940:Circadian Rhythm; D015232:Dinoprostone / Q000031:analogs & derivatives*; D004311:Double-Blind Method; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008297:Male; D010434:Pepsin A / Q000378:metabolism*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D011897:Random Allocation; D013997:Time Factors
D011459:Prostaglandins E, Synthetic; C038879:trimoprostil; D010434:Pepsin A; D015232:Dinoprostone