Enzyme activities and ultrastructure of intestinal epithelium in the mouse treated with chloramphenicol.
Several enzyme activities in the enteric mucous membrane (maltase, lactase, leucineaminopeptidase) were assayed and intestinal epithelium ultrastructure was evaluated in mice treated with chloramphenicol, per os, in different doses (50 mg/Kg and 100 mg/Kg), for 10 days. Of the enzyme activities assayed, only leucineaminopeptidase was found to be significantly lower in treated animals than in controls. Enterocyte ultrastructure and mitochondrial morphometrical parameters were not found to be significantly modified in treated animals.
D000284:Administration, Oral; D000818:Animals; D002701:Chloramphenicol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D007931:Leucyl Aminopeptidase / Q000032:analysis; D008297:Male; D051379:Mice; D008928:Mitochondria / Q000187:drug effects; D000520:alpha-Glucosidases / Q000032:analysis; D001616:beta-Galactosidase / Q000032:analysis
D002701:Chloramphenicol; D000520:alpha-Glucosidases; D001616:beta-Galactosidase; D007931:Leucyl Aminopeptidase