Changes in liver polyamines due to aflatoxin B1.
Changes in liver polyamines of rats and mice of both sexes injected with aflatoxin B1 (AFB1) were determined. AFB1 significantly enhanced liver polyamines of both susceptible and resistant animals, viz. rats and mice, respectively. Sex appears to have little influence on AFB1-mediated stimulation of liver polyamine levels. AFB1 significantly reduced liver polyamine in growing rats reflecting the inhibitory effect of this carcinogen on induced polyamine synthesis.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000494:pharmacology*; D000375:Aging / Q000378:metabolism; D000818:Animals; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D011073:Polyamines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013045:Species Specificity
D000348:Aflatoxins; D011073:Polyamines; D016604:Aflatoxin B1