Parenteral nutrition-associated cholestasis: recovery following phenobarbitone.
A case is presented of a very preterm neonate who developed severe cholestatic jaundice in association with prolonged parenteral nutrition. The effects of a therapeutic trial of phenobarbitone on bilirubin and liver enzymes are shown. This case suggests that phenobarbitone may have a role to play in the treatment of this condition, which is contrary to indications in a few other case reports in the literature.
D001663:Bilirubin / Q000097:blood; D002780:Cholestasis, Intrahepatic / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010288:Parenteral Nutrition / Q000009:adverse effects*; D010634:Phenobarbital / Q000627:therapeutic use
D001663:Bilirubin; D010634:Phenobarbital