title: Monitoring of tissue-pO2 for invasive diagnostics in angiology and vascular surgery.
abstract: Hypoxic and ischemic states are the main problem makers in angiology and vascular surgery. It is therefore suggestive to employ the technique of tissue-pO2 measurement for the verification and support of diagnostic and therapeutic measures. Two forms of registration are possible: continuous monitoring of partial oxygen pressures in eight different places and registration in the form of pO2-histograms, which represents a kind of "representative opinion poll" held in the tissue. The effects of a surgical intervention (endarterectomy, bypass operation) and the efficacy of blood flow-promoting drugs were studied in several series. In 9 patients the effect of the blood flow-promoting agent pentoxifylline (3,7-dimethyl-1-(5-oxohexyl)-xanthine) was studied. The pO2-histograms exhibited a shift to the right by an average of 7 mmHg after administration of this drug. Moreover, findings obtained with sodium nitroprusside and nitroglycerin during induced hypotension indicate that the continuous measuring of tissue-pO2 and recording of oxygen pressure distribution curves (pO2-histogram) provide the clinician with essential guidance data for the improvement of diagnostics and therapeutic control.
mesh_terms: D001775:Blood Circulation / Q000187:drug effects; D002196:Capillaries / Q000502:physiology; D004566:Electrodes; D006801:Humans; D007023:Hypotension, Controlled; D008991:Monitoring, Physiologic; D005996:Nitroglycerin / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D010100:Oxygen / Q000502:physiology*; D010313:Partial Pressure; D010431:Pentoxifylline / Q000494:pharmacology; D014656:Vascular Surgical Procedures
chemical_list: D009599:Nitroprusside; D005996:Nitroglycerin; D010100:Oxygen; D010431:Pentoxifylline