Prophylactic treatment with valproic acid or diazepam in children with febrile convulsions.
The purpose of this study was to limit prophylactic treatment of children with febrile convulsions to patients who have the highest risk of recurrence. Two hundred and thirty-one children with a first febrile seizure were divided into high- and low-risk groups according to estimated risk of recurrence. All high-risk children were offered treatment with valproic acid. If this was declined they were offered treatment with diazepam instead. Low-risk children were untreated. Valproic acid and diazepam were found to be equally effective in reducing the risk of recurrence of febrile convulsions. By selecting for prophylactic treatment according to estimated risk of recurrence it is possible to reduce the rate of recurrence of febrile seizures in children at high-risk (60%) to the same level as that of untreated low-risk children (23%). Only about half of all children with febrile convulsions need treatment and follow-up according to these criteria.
D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012008:Recurrence; D012306:Risk; D003294:Seizures, Febrile / Q000517:prevention & control*; D014635:Valproic Acid / Q000627:therapeutic use*
D014635:Valproic Acid; D003975:Diazepam