Effect of dietary carbohydrate type and content on the response of male rats to dietary sodium saccharin.
The role of dietary carbohydrate composition and concentration in the response of male rats to sodium saccharin (NaS) was ascertained by comparing the response to 5% dietary NaS in rats given diets containing 65% starch, 50% sucrose together with 15% starch, 65% glucose, or 3% sucrose. NaS induced similar levels of caecal enlargement and increases in urine volume and bladder mass when given with any of the three forms of carbohydrate at 65% in the diet. However with the 3% sucrose diet, NaS caused a lesser caecal enlargement and no increase in urine volume or bladder mass. These findings suggest that NaS not only inhibits saccharide hydrolysis but also inhibits glucose transport. The significance of these findings in relation to NaS-associated bladder tumours is discussed.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002432:Cecum / Q000187:drug effects; D004032:Diet; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects; D007200:Indican / Q000652:urine; D008297:Male; D008903:Minerals / Q000652:urine; D051381:Rats; D012439:Saccharin / Q000633:toxicity* / Q000652:urine; D001743:Urinary Bladder / Q000187:drug effects; D014556:Urine / Q000187:drug effects
D004040:Dietary Carbohydrates; D008903:Minerals; D012439:Saccharin; D007200:Indican