title: [Clinical use of yohimbine as an antagonist of xylazine depression of the central nervous system in cats].
abstract: Antagonizing effects of various doses of yohimbine on a xylazine depression of the cerebroneural system (CNS) were studied in cats. Administration of various doses of yohimbine was investigated with respect to its antagonizing effects on various doses of xylazine. The time of CNS depression induced by commonly recommended doses of xylazine (2-4 mg/kg live weight) was shortened statistically significantly by intramuscular injections of yohimbine at a dose of 3 mg per kg live weight. After this yohimbine dose, the animals recovered consciousness already 10-15 minutes from application, with the complete resumption of reflexes. Preventive administration of the same dose of yohimbine hindered reliably the full development of CNS depression after the two xylazine doses (2 and 4 mg/kg live weight).
mesh_terms: D000818:Animals; D002415:Cats / Q000502:physiology*; D002490:Central Nervous System / Q000187:drug effects*; D003864:Depression, Chemical; D013843:Thiazines / Q000494:pharmacology*; D014991:Xylazine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D015016:Yohimbine / Q000494:pharmacology*
chemical_list: D013843:Thiazines; D014991:Xylazine; D015016:Yohimbine
vernacular_title: Klinické vyuzití yohimbinu jako antagonisty xylazinové deprese CNS u kocek.