Lithium potentiation of tricyclic antidepressants following lack of T3 potentiation.
Four patients whose depressions were failing to respond to administration of tricyclic antidepressants were given separate trials of T3 and lithium. In all four cases, T3 failed to potentiate the antidepressant, whereas the lithium did.
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004351:Drug Resistance; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008094:Lithium / Q000494:pharmacology / Q000627:therapeutic use*; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D014284:Triiodothyronine / Q000494:pharmacology / Q000627:therapeutic use*
D000929:Antidepressive Agents, Tricyclic; D014284:Triiodothyronine; D016651:Lithium Carbonate; D008094:Lithium