title: Promoting effect of 12-O-tetradecanoylphorbol-13-acetate on neurogenic microtumors initiated by transplacental exposure to N-ethyl-N-nitrosourea.
abstract: The promoting effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the occurrence of neurogenic microtumors in SD-JCL rats initiated transplacentally with N-ethyl-N-nitrosourea (ENU) was investigated. The treatment with TPA induced earlier occurrence of microtumors than as compared with the initiation alone. Thus, TPA has tumor-promoting activity on the formation of neurogenic microtumors in rats prenatally exposed to ENU.
mesh_terms: D000818:Animals; D001254:Astrocytoma / Q000139:chemically induced; D001932:Brain Neoplasms / Q000139:chemically induced*; D003043:Cocarcinogenesis; D004806:Ependymoma / Q000139:chemically induced; D005038:Ethylnitrosourea; D005260:Female; D005910:Glioma / Q000139:chemically induced; D008297:Male; D008431:Maternal-Fetal Exchange; D009837:Oligodendroglioma / Q000139:chemically induced; D010920:Placenta; D011247:Pregnancy; D051381:Rats; D013755:Tetradecanoylphorbol Acetate
chemical_list: D013755:Tetradecanoylphorbol Acetate; D005038:Ethylnitrosourea