[Physiopathological approach to pathological hyperlactatemia in the diabetic patient. Value of blood metformin].
Type B lactic acidosis, or pathological hyperlactatemia (PHL), is defined by an arterial lactate level greater than 5 mmol X l-1. It is a known and severe complication of diabetes mellitus treated with biguanide hypoglycaemic agents, particularly phenformin which was taken off the French pharmaceutical market in 1977. Metformin, which remains the only biguanide hypoglycaemic agent currently prescribed in France, may also lead to this complication. However it does so less frequently and mostly in the diabetic presenting with renal failure. A few well studied cases showed that PHL could be correlated with excessive metformin blood levels, i.e. a toxic mechanism. In order to find out whether this toxic mechanism was the real cause of PHL in diabetics treated with metformin, a systematic study of metformin blood levels was carried out in 20 such patients. They had all been admitted to a critical care unit presenting with PHL. The results of this study led us to distinguish between two groups of patients. The seven patients of the first group had high metformin blood levels (4.3 to 65.8 micrograms X l-1). In these, renal excretion or extrarenal dialysis lowered or normalized their hyperlactatemia, and six of the seven recovered from PHL. In the second group, with thirteen patients, metformin blood levels were within the normal therapeutic range (0.225 to 3 micrograms X l-1) for seven patients and close to zero for the other six. This second group received the same treatment as the first one. Only three patients recovered, the others all died.(ABSTRACT TRUNCATED AT 250 WORDS)
D000140:Acidosis, Lactic / Q000097:blood* / Q000139:chemically induced / Q000503:physiopathology; D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D016883:Diabetic Ketoacidosis / Q000097:blood*; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood*; D008297:Male; D008687:Metformin / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D008875:Middle Aged
D007773:Lactates; D008687:Metformin
Approche physiopathologique des hyperlactatémies pathologiques chez le diabétique. Intérêt de la metforminémie.