Increased factor VIII as an index of vascular injury in cyclosporine nephrotoxicity.
Very high plasma concentrations of factor-VIII-related antigen (RAG) (VIII-RAG) were found in renal allograft recipients during periods of nephrotoxicity induced by cyclosporine. In eight recipients, who were investigated at weekly intervals, levels of factor-VIII-RAG fell toward normal as the dose of cyclosporine was reduced. Plasma levels of C-reactive protein, an acute phase reactant protein, were never raised in these recipients. These findings are further evidence that toxic doses of cyclosporine are associated with vascular injury.
D000941:Antigens / Q000032:analysis*; D003524:Cyclosporins / Q000633:toxicity*; D004797:Enzyme-Linked Immunosorbent Assay; D005169:Factor VIII / Q000032:analysis / Q000276:immunology*; D006801:Humans; D007122:Immunoelectrophoresis / Q000379:methods; D007668:Kidney / Q000187:drug effects*; D016030:Kidney Transplantation; D012077:Renal Artery / Q000293:injuries*; D012082:Renal Veins / Q000293:injuries*; D014184:Transplantation, Homologous; D014841:von Willebrand Factor
D000941:Antigens; D003524:Cyclosporins; D014841:von Willebrand Factor; D005169:Factor VIII