Interaction of mistletoe lectin I with Kupffer cells and endothelial cells of mouse liver.
The in vitro-formation of blebs by endothelial and Kupffer cells of the mouse liver after treatment with the toxic lectin I from mistletoe are demonstrated by means of scanning electron microscopy. The interaction of toxic lectins with nonparenchymal liver cells can be of importance concerning the elimination of these lectins in vivo.
D000818:Animals; D004727:Endothelium / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D007728:Kupffer Cells / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D051379:Mice; D008805:Mice, Inbred A; D008855:Microscopy, Electron, Scanning; D028321:Plant Preparations; D010940:Plant Proteins; D054790:Ribosome Inactivating Proteins, Type 2; D014118:Toxins, Biological / Q000378:metabolism* / Q000633:toxicity
D028321:Plant Preparations; D010940:Plant Proteins; D054790:Ribosome Inactivating Proteins, Type 2; D014118:Toxins, Biological; C009674:ribosome inactivating protein, Viscum