title: Action of a prostaglandin synthetase inhibitor on IUD associated uterine bleeding.
abstract: The Authors treated twenty-eight women using IUD, who suffered from increased menstrual blood loss and pelvic pain, with a prostaglandin synthetase inhibitor, Suprofen, in an attempt to reduce their symptomatology, in a double blind crossover study. The drug produced an important reduction of the menstrual blood loss and pains. These observations suggest that prostaglandins are involved in the etiology of excessive menstrual blood loss and pains, and that prostaglandin inhibitors may be useful for reducing these symptoms.
mesh_terms: D002986:Clinical Trials as Topic; D016861:Cyclooxygenase Inhibitors; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007434:Intrauterine Devices / Q000009:adverse effects*; D008595:Menorrhagia / Q000188:drug therapy*; D010666:Phenylpropionates / Q000627:therapeutic use*; D013496:Suprofen / Q000627:therapeutic use*
chemical_list: D016861:Cyclooxygenase Inhibitors; D010666:Phenylpropionates; D013496:Suprofen