title: [Hemodynamic effect of the clamping of the carotid in the surgically treated coronary patient].
abstract: To determine both the incidence of myocardial ischaemia and haemodynamic response to carotid cross-clamping in coronary artery disease, 30 patients undergoing carotid endarterectomy were studied with a clear history of effort related disabling angina pectoris. Myocardial ischaemia was detected by a recording of lead CM5 of the electrocardiogram. A radial arterial and a thermodilution pulmonary catheter were inserted to obtain haemodynamic measurements before and after carotid cross-clamping and unclamping. Anaesthesia was induced with increments of thiopental, fentanyl 6 micrograms X kg-1 and pancuronium. Additional fentanyl (2 micrograms X kg-1) was injected before skin incision and before carotid cross-clamping. Carotid cross-clamping results in a significant increase in both mean arterial blood pressure and capillary wedge pressure. Two patients experienced myocardial ischaemia with ST segment depression during carotid cross-clamping. Nitroglycerin infusion led to the improvement of ST segment depression. When halothane was additionally administered to patients who developed hypertension in response to carotid cross-clamping, arterial blood pressure returned to normal value. These results indicate that carotid cross-clamping increases determinants of myocardial oxygen demand and may cause myocardial ischaemia in patients suffering from angina pectoris.
mesh_terms: D000368:Aged; D000768:Anesthesia, General / Q000379:methods; D002340:Carotid Artery Diseases / Q000601:surgery*; D003250:Constriction; D003327:Coronary Disease / Q000503:physiopathology*; D004562:Electrocardiography; D004691:Endarterectomy; D005260:Female; D006221:Halothane / Q000494:pharmacology; D006439:Hemodynamics; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D005996:Nitroglycerin / Q000008:administration & dosage
chemical_list: D005996:Nitroglycerin; D006221:Halothane
vernacular_title: Retentissement hémodynamique du clampage de la carotide chez l'opéré coronarien.