title: Effects of alfentanil on the pressor and catecholamine responses to tracheal intubation.
abstract: The effects of alfentanil (given during induction of anaesthesia) on the haemodynamic and catecholamine responses to tracheal intubation were studied in 44 adult patients who received alfentanil 10 micrograms kg-1 or 40 micrograms kg-1, or saline placebo. Alfentanil 10 micrograms kg-1 and 40 micrograms kg-1 prevented any increase in heart rate and arterial pressure after tracheal intubation. Alfentanil 40 micrograms kg-1 produced profound hypotension and bradycardia. The use of alfentanil in both doses was associated with a decrease in plasma adrenaline concentrations after tracheal intubation.
mesh_terms: D000368:Aged; D015760:Alfentanil; D000777:Anesthetics / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004837:Epinephrine / Q000097:blood*; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D013997:Time Factors
chemical_list: D000777:Anesthetics; D015760:Alfentanil; D005283:Fentanyl; D009638:Norepinephrine; D004837:Epinephrine