Plausible mechanism of inactivation of plasma alpha 1-proteinase inhibitor by acrolein.
Evidence is presented to show that inactivation of alpha 1-proteinase inhibitor caused by acrolein depends upon the modification of lysine and histidine residues. Approximately 90% activity was lost when twenty three lysine and eight histidine residues were modified.
D000171:Acrolein / Q000494:pharmacology*; D000447:Aldehydes / Q000494:pharmacology*; D000596:Amino Acids / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis / Q000037:antagonists & inhibitors*; D055598:Chemical Phenomena; D002621:Chemistry; D006639:Histidine / Q000032:analysis; D006801:Humans; D008239:Lysine / Q000032:analysis; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D000515:alpha 1-Antitrypsin
D000447:Aldehydes; D000596:Amino Acids; D001798:Blood Proteins; D000515:alpha 1-Antitrypsin; D006639:Histidine; D000171:Acrolein; D010196:Pancreatic Elastase; D008239:Lysine