A new HLA-linked T cell membrane molecule, related to the beta chain of the clonotypic receptor, is associated with T3.
The 38 kD molecule is noncovalently associated with beta 2 microglobulin (beta 2m)-free HLA heavy chain-like molecule, and thus forms a second heterodimer distinct from the clonotypic alpha/beta T cell receptor expressed by the same clone of leukemia cells. This second heterodimer (38 kD/HLA) is variably expressed and appears to be associated with the T3 molecule. We suggest, therefore, that it has a functional role in T cell activation.
D000911:Antibodies, Monoclonal; D000937:Antigen-Antibody Reactions; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000032:analysis* / Q000276:immunology; D002999:Clone Cells / Q000378:metabolism; D006680:HLA Antigens / Q000032:analysis* / Q000276:immunology; D006801:Humans; D007525:Isoelectric Focusing; D007945:Leukemia, Lymphoid / Q000276:immunology; D046911:Macromolecular Substances; D008970:Molecular Weight; D010446:Peptide Fragments / Q000302:isolation & purification; D011233:Precipitin Tests; D011948:Receptors, Antigen, T-Cell / Q000032:analysis*; D001613:beta 2-Microglobulin / Q000276:immunology
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D006680:HLA Antigens; D046911:Macromolecular Substances; D010446:Peptide Fragments; D011948:Receptors, Antigen, T-Cell; D001613:beta 2-Microglobulin