Bromocriptine and apomorphine stimulation of cortisol secretion in conscious dogs; evidence for a stimulatory site located outside the blood brain barrier.
IV injections of the dopamine receptor agonists bromocriptine (0.1 mg/kg) and apomorphine (0.05 mg/kg) induced rapid and long-lasting increases of cortisol levels as measured by RIA in peripheral venous plasma of conscious dogs. Pretreatment with dopamine receptor antagonists which do not readily penetrate the blood brain barrier (domperidone, halopemide, sulpiride) abolished the release responses induced by the dopamine agonists. These results suggest that the dopamine receptor agonists stimulate cortisol release at a site located outside the blood brain barrier. In addition, some dopamine receptor antagonists (haloperidol, chlorpromazine, milenperone) were shown to cause a rapid and long-lasting increase of cortisol levels.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001812:Blood-Brain Barrier; D001971:Bromocriptine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004285:Dogs; D004294:Domperidone / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D011954:Receptors, Dopamine / Q000187:drug effects; D013469:Sulpiride / Q000494:pharmacology
D011954:Receptors, Dopamine; D001971:Bromocriptine; D004294:Domperidone; C017357:halopemide; D013469:Sulpiride; D001058:Apomorphine; D006854:Hydrocortisone