title: Effects of almitrine bismesylate 100 mg daily for four weeks on respiratory regulation in patients with chronic bronchitis.
abstract: The effects on respiratory regulation of giving almitrine bismesylate (100 mg daily) orally for four weeks in twelve patients with chronic airflow obstruction were assessed in a double-blind placebo-controlled study. The drug caused significant increases in ventilation and the ventilatory response to hypoxia, associated with partial relief of arterial hypoxaemia and a fall in arterial CO2 tension. No consistent changes occurred with placebo. The results are in accord with a sustained action of almitrine bismesylates sensitising peripheral chemoreception.
mesh_terms: D015765:Almitrine; D001991:Bronchitis / Q000188:drug therapy / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood; D002628:Chemoreceptor Cells / Q000187:drug effects; D006801:Humans; D010100:Oxygen / Q000097:blood; D010879:Piperazines / Q000008:administration & dosage* / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects*
chemical_list: D010879:Piperazines; D002245:Carbon Dioxide; D015765:Almitrine; D010100:Oxygen