title: [Difference in the maturation of the three-domain vasopressin precursor in the guinea-pig and rat: identification of a neurophysin-copeptin fragment in the guinea pig].
abstract: Vasopressin, MSEL-neurophysin and copeptin have been isolated from guinea pig and rat neurophypophyses and their amino acid sequences have been determined. Whereas in rat processing of the three-domain precursor is complete, in the guinea pig a 132-residue fragment including MSEL-neurophysin and copeptin linked by an arginine residue has been characterized. This incomplete maturation (20% of the precursor) could be due to a deletion of an acidic residue in guinea pig copeptin when compared with other mammalian copeptins.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006020:Glycopeptides / Q000032:analysis; D006168:Guinea Pigs; D009481:Neurophysins / Q000032:analysis*; D010904:Pituitary Gland, Posterior / Q000032:analysis*; D011498:Protein Precursors / Q000032:analysis*; D051381:Rats; D014667:Vasopressins / Q000032:analysis*
chemical_list: D006020:Glycopeptides; D009481:Neurophysins; D011498:Protein Precursors; D014667:Vasopressins
vernacular_title: Différence dans la maturation du précurseur tridomanial de la vasopressine chez le cobaye et le rat: identification d'un fragment neurophysine-copeptine chez le cobaye.