Effect of encainide on in vivo drug metabolism in the rat.
The effect of encainide, an investigational antiarrhythmic, on drug metabolism was examined using the model substrate antipyrine. Administration of a single oral dose of encainide hydrochloride 100 mg/kg one hour prior to antipyrine administration resulted in a mean 30% reduction in antipyrine clearance. These data indicate that encainide, like other agents subject to substantial first-pass metabolism, is capable of inhibiting oxidative drug metabolism.
D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D000983:Antipyrine / Q000097:blood / Q000378:metabolism*; D003864:Depression, Chemical; D016700:Encainide; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000813:Anilides; D000889:Anti-Arrhythmia Agents; D016700:Encainide; D000983:Antipyrine