A double-blind crossover trial of CMC- and mucin-containing saliva substitutes.
The aim of this investigation was to describe and to compare the effectiveness of a CMC- and a mucin-containing saliva substitute. 22 post-radiation patients, 17 Sjögren's Syndrome patients and 3 patients with xerostomia of unknown origin used a CMC- and a mucin-containing saliva substitute, each for 1 week in an arbitrary sequence. Neither the patient, the assistant, nor the physician were aware of the substitute being used. Each patient had to complete a questionnaire at 3 different intervals during the trial. One of the conclusions of this study is that mucin-containing substitutes are preferred by patients when compared to CMC-containing substitutes.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives*; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D009077:Mucins / Q000627:therapeutic use*; D011832:Radiation Injuries / Q000150:complications; D012464:Saliva, Artificial / Q000627:therapeutic use*; D012859:Sjogren's Syndrome / Q000150:complications; D014987:Xerostomia / Q000209:etiology / Q000628:therapy*
D009067:Mouthwashes; D009077:Mucins; D012464:Saliva, Artificial; D008747:Methylcellulose; D002266:Carboxymethylcellulose Sodium