Influenza virus strains with a fusion threshold of pH 5.5 or lower are inhibited by amantadine. Brief report.
Nineteen influenza virus strains were examined for susceptibility to amantadine-HCl (AMT) and for pH-thresholds of haemagglutinin-induced haemolysis. Whereas pH-thresholds below 5.5 were not seen in AMT-resistant strains, AMT-sensitive strains showed pH-thresholds either below or above 5.5.
D000547:Amantadine / Q000494:pharmacology*; D000818:Animals; D002459:Cell Fusion; D002460:Cell Line; D004351:Drug Resistance; D004705:Endocytosis; D000882:Haplorhini; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral / Q000502:physiology; D006462:Hemolytic Plaque Technique; D006863:Hydrogen-Ion Concentration; D007668:Kidney; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000502:physiology; D011487:Protein Conformation
D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral; D000547:Amantadine