Effect of a simulated 3,048 meter altitude on the single-breath transfer factor.
The single-breath transfer factor (TLCO) was measured in ten healthy subjects at sea level and at a simulated altitude of 3,048 m. Measurements were made at sea level using 21% oxygen and at altitude using both 21% and 31% oxygen in the test gas. At 3,048 m altitude (PB = 69.7 kPa), the mean TLCO increased 14% or about 2.3% per kPa (0.3% per mmHg) decrease in inspired oxygen pressure. Our data also suggests that altering the test gas oxygen concentration to account for the change in PAO2 due to altitude results in a TLCO equivalent to that obtained at sea level.
D000328:Adult; D000531:Altitude; D001944:Breath Tests; D002245:Carbon Dioxide; D002248:Carbon Monoxide; D005260:Female; D006801:Humans; D008297:Male; D010100:Oxygen; D011653:Pulmonary Diffusing Capacity
D002245:Carbon Dioxide; D002248:Carbon Monoxide; D010100:Oxygen