[Glucose tolerance in intensive care premature infants with a birth weight below 1,500 g in the first 5 days].
Plasma insulin and blood glucose values were studied in 11 stressed premature infants with birth weight below 1 500 g during the first five days after birth under increasing fluid and glucose infusion rates. The group 11 small premature neonates was subdivided; group A consisted of 6 stressed premature infants with respiratory distress syndrome (RDS stage III-IV) and/or intraventricular haemorrhage (IVH stage III-IV), and group B of 5 slightly stressed premature infants with RDS (stage I-II and/or IVH (stage I-II). During the first two days there was no difference in caloric and fluid intake in both groups. From the third day on caloric intake was much higher in group B than in group A (day 5: group A: 61.33 +/- 13.01 kcal/kg BW; group B: 78.2 +/- 18.49 kcal/kg BW). Plasma insulin values increased in both groups during the first five days after birth (group A: day 1: mean plasma insulin values 8.18 +/- 7.59 microU/ml; day 4: 27.22 +/- 32.85 microU/ml; group B: day 1: mean plasma insulin values 4.34 +/- 2.62; day 4: 11.18 +/- 8.38). Blood glucose and plasma insulin values were significantly higher in group A than in group B.


CONCLUSIONS
Impaired glucose utilisation in severely stressed premature infants with parenteral nutrition might be due to stress induced peripheral insulin resistance.
D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood*; D007328:Insulin / Q000097:blood*; D007363:Intensive Care Units, Neonatal; D010289:Parenteral Nutrition, Total; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood
D001786:Blood Glucose; D007328:Insulin
Glukosetoleranz bei intensivgepflegten Frühgeborenen unter 1 500 g Geburtsgewicht während der ersten fünf Lebenstage.