[Photosensitivity in human pathology: mechanisms and clinical aspects].
Photosensitivity diseases are reviewed. The pathogenesis of photodermatoses is not completely elucidated, especially because the photosensitizing agents are rarely identified. In exogenous photosensitization, the chemical agent (chromophore) is most often identified, reaching the skin either via topical contact or by systemic administration (drugs). Concepts of phototoxicity (photochemical reaction) and photo-allergy (photo-immunologic reaction) explain the clinical aspects. Dermatoses with photosensitivity are divided into three groups: photo-aggravated dermatoses (solar herpes, lupus erythematosus), photosensitivity caused by protective system defect (xeroderma pigmentosum), and photosensitivity caused by metabolic defects (porphyrias, pellagra). Idiopathic photodermatoses (unknown chromophore) are triggered by solar exposure (systemic photo-allergens would serve as mediators): 'benign estival polymorphous light eruption', polymorphous light eruptions, persistent light reactor, solar urticaria.
D000328:Adult; D004247:DNA / Q000528:radiation effects; D005260:Female; D011564:Furocoumarins / Q000009:adverse effects; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology; D010383:Pellagra / Q000150:complications; D010777:Photochemistry; D010787:Photosensitivity Disorders / Q000139:chemically induced / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D011164:Porphyrias / Q000150:complications; D012458:Salicylanilides / Q000009:adverse effects; D012871:Skin Diseases / Q000209:etiology; D013472:Sunlight / Q000009:adverse effects; D014466:Ultraviolet Rays; D014581:Urticaria / Q000209:etiology / Q000276:immunology; D014983:Xeroderma Pigmentosum / Q000150:complications
D011564:Furocoumarins; D012458:Salicylanilides; D004247:DNA
La photosensibilité en pathologie humaine: mécanismes et aspects cliniques.