title: [Cholestasis in total parenteral nutrition--a review].
abstract: Intrahepatic cholestasis is a frequent, however unresolved complication of total parenteral nutrition in infancy. A frequency of 10-50% is reported. The concentration of serum bile acids seems to be a sensitive indicator for a beginning cholestasis. As typical histological alterations of the liver are considered: inflammatory portal reaction, fibrosis and proliferation of bile ducts. As important components of the obviously multifactorial etiology are considered: lacking oral alimentation, fetal bile acid synthetic pathways, amino acid toxicity, hypoalbuminemia, sepsis and substrate excess.
mesh_terms: D001647:Bile Acids and Salts / Q000378:metabolism; D002780:Cholestasis, Intrahepatic / Q000473:pathology* / Q000628:therapy; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology; D010289:Parenteral Nutrition, Total; D018805:Sepsis / Q000150:complications
chemical_list: D001647:Bile Acids and Salts; D005217:Fat Emulsions, Intravenous
vernacular_title: Cholestase bei totaler parenteraler Ernährung (TPE)--Eine Ubersicht.