title: In vivo response times for a heated skin surface CO2 electrode during rest and exercise.
abstract: The continuous, noninvasive estimation of arterial carbon dioxide tension (PaCO2) by heated skin surface electrodes has recently become available for pediatric patients. Skin surface (PsCO2) electrodes can enhance the safety of procedures such as intubation, bronchoscopy, ventilator changes, sleep studies, or measurement of the ventilatory response to CO2 or hypoxia. However, clinical situations that include rapid changes in PaCO2 demand knowledge of the in vivo response time. We compared the response of a heated PsCO2 electrode to end tidal CO2 (PetCO2) during abrupt changes in inspired CO2 from room air to 7% CO2 and back to room air. We obtained 54 curves on nine healthy subjects. There was an initial lag time with less than a 10% change in PsCO2. Then PsCO2 approached PetCO2 exponentially. For subjects at rest changing from breathing room air to 7% CO2, the initial lag time was 40 +/- 2 seconds and the 50% response time of the exponential portion was 46 +/- 3 seconds. Thus, it took 86 seconds for the electrode to record a 60% response to an abrupt increase in inspired CO2. The initial lag and 50% response time were considerably shorter during exercise (30 +/- 2 and 33 +/- 2 seconds) and even shorter when switched from breathing 7% CO2 to room air (23 +/- 2 and 21 +/- 2 seconds). Exercise did not further reduce the response time when CO2 was initially elevated, suggesting the faster response time was due to vasodilation of the skin due to elevated CO2.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000293:Adolescent; D000328:Adult; D002245:Carbon Dioxide / Q000502:physiology*; D002302:Cardiac Output; D004566:Electrodes; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008297:Male; D005082:Physical Exertion; D011659:Pulmonary Gas Exchange; D011930:Reaction Time / Q000502:physiology*; D012879:Skin Physiological Phenomena
chemical_list: D002245:Carbon Dioxide