Phenolic aminocarboxylate chelates of 99mTc as hepatobiliary agents.
A series of alkyl- and halogen-substituted derivatives of ethylenediamine di[o-hydroxyphenylacetic acid] (EDDHA) and N,N'-bis[2-hydroxybenzyl] ethylenediamine N,N'-diacetic acid (HBED) were complexed with 99mTc and their biodistribution was determined in rats. All complexes displayed substantial hepatobiliary excretion; of each series, 99mTc-Br-EDDHA and 99mTc-di-Cl-HBED had the maximum amount in the gastrointestinal tract. Scintigraphic studies of 99mTc-Cl-EDDHA in dogs revealed prompt imaging of the liver followed by imaging of the gall bladder as the complex was excreted into the bile.
D000818:Animals; D004492:Edetic Acid / Q000031:analogs & derivatives*; D005029:Ethylenediamines; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging*; D008099:Liver / Q000000981:diagnostic imaging*; D008657:Metabolic Clearance Rate; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium
D005029:Ethylenediamines; C011813:ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid); C037740:N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid; D013667:Technetium; D004492:Edetic Acid