Clonal origin of radiation-induced myeloid leukemia in mice with cellular mosaicism.
The clonal origin of radiation-induced myeloid leukemia was studied in mice with cellular mosaicism for phosphoglycerate kinase (PGK). A single whole-body X-irradiation of 3 Gy resulted in development of 11 myeloid leukemias in 198 mosaic mice (5.6%). PGK of spleen cells from 9 myeloid leukemias assayed gave only a single band on electrophoresis. PGK of red blood cells (RBC) from one myeloid leukemia gave a single band identical to that of PGK of leukemic cells, while PGK of RBC from 4 other myeloid leukemias gave two bands. From these results, we concluded that radiation-induced myeloid leukemias in mice were of single cell origin, and that the origin of some myeloid leukemias might be a progenitor cell capable of differentiating into both erythroid and myeloid series.
D000818:Animals; D002999:Clone Cells / Q000032:analysis*; D005819:Genetic Markers; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000473:pathology*; D007953:Leukemia, Radiation-Induced / Q000235:genetics / Q000473:pathology*; D051379:Mice; D008809:Mice, Inbred C3H; D009030:Mosaicism; D010735:Phosphoglycerate Kinase / Q000235:genetics
D005819:Genetic Markers; D010735:Phosphoglycerate Kinase