title: Activation of the pulmonary arachidonic acid system and its consequences for hemodynamics and fluid balance.
abstract: The pulmonary vasculature and perivascular tissue is able to generate arachidonic acid metabolites with strong effects on vascular tone and permeability. Stimulators of the pulmonary arachidonic acid metabolism, which represents a highly potent mediator system, are components of the classical cascade systems, bacterial toxins, hypoxia, and a variety of other physiological and non-physiological factors. Upon excessive stimulation, the pulmonary circulation responds with vasoconstriction and extravasation. Since granulocytes are always involved, their contribution to the resulting vascular effects has to be considered.
mesh_terms: D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D004537:Eicosanoic Acids / Q000378:metabolism; D004731:Endotoxins / Q000494:pharmacology; D006098:Granulocytes / Q000378:metabolism; D008168:Lung / Q000098:blood supply / Q000378:metabolism*; D010100:Oxygen / Q000502:physiology
chemical_list: D001095:Arachidonic Acids; D004537:Eicosanoic Acids; D004731:Endotoxins; D016718:Arachidonic Acid; D010100:Oxygen