Inhalation of carbon dioxide enhances the coronary vasodilating action of isosorbide dinitrate in the dog.
Two kinds of inspiratory gases, 100% O2 and 81% O2 + 19% CO2, were used for the artificial respiration. Elevating the inspiratory CO2 tension enhanced the decrease in coronary vascular resistance caused by isosorbide dinitrate (100 micrograms/kg), without any change in heart rate and systemic arterial pressure. Such a change in coronary vascular resistance was prevented by indomethacin. The results suggested an interaction between isosorbide dinitrate and CO2, which was mediated by prostaglandins.
D000138:Acidosis / Q000378:metabolism; D000280:Administration, Inhalation; D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology*; D003331:Coronary Vessels / Q000187:drug effects*; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D007548:Isosorbide Dinitrate / Q000494:pharmacology*; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D002245:Carbon Dioxide; D007548:Isosorbide Dinitrate; D007213:Indomethacin