[Secondary failure of oral antidiabetics. Value of intravenous insulin infusions].
A temporary strict blood glucose control was achieved by means of intravenous insulin infusion in 37 non insulin-dependent diabetic patients with secondary drug failure to reinduce the efficacy of oral hypoglycemic agents. This procedure was successful in 18 patients (48.6%) resulting in better glycemic response to oral hypoglycemic agents. Results remained identical 6 and 12 months later. This improvement does not seem related to an increase in insulin secretion as urinary C-peptide and basal and glucagon-stimulated plasma C-peptide were identical before and after insulin infusion. We suggest that a decrease in insulin resistance, not tested in this study, may explain the beneficial effect or normoglycemia in our patients.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D002096:C-Peptide / Q000097:blood / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005905:Glyburide / Q000627:therapeutic use; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007332:Insulin Infusion Systems; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D008875:Middle Aged
D001786:Blood Glucose; D002096:C-Peptide; D005905:Glyburide; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D008687:Metformin
Echec secondaire des antidiabétiques oraux. Intérêt des infusions insuliniques intraveineuses.