An evolutionary conserved early replicating segment on the sex chromosomes of man and the great apes.
Replication studies on prometaphase chromosomes of man, the chimpanzee, the pygmy chimpanzee, the gorilla, and the orangutan reveal great interspecific homologies between the autosomes. The early replicating X chromosomes clearly show a high degree of conservation of both the pattern and the time course of replication. An early replicating segment on the short arm of the X chromosomes of man (Xp22.3) which escapes inactivation can be found on the X chromosomes of the great apes as well. Furthermore, the most early replicating segment on the Y chromosomes of all species tested appears to be homologous to this segment on the X chromosomes. Therefore, these early replicating segments in the great apes may correspond to the pseudoautosomal segment proposed to exist in man. From further cytogenetic characterization of the Y chromosomes it is evident that structural alterations have resulted in an extreme divergence in both the euchromatic and heterochromatic parts. It is assumed, therefore, that, in contrast to the X chromosomes, the Y chromosomes have undergone a rapid evolution within the higher primates.
D000818:Animals; D005075:Biological Evolution; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002871:Chromosome Banding; D004261:DNA Replication / Q000187:drug effects; D005260:Female; D006071:Gorilla gorilla / Q000235:genetics*; D000882:Haplorhini / Q000235:genetics*; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D002679:Pan troglodytes / Q000235:genetics*; D011148:Pongo pygmaeus / Q000235:genetics*; D012730:Sex Chromosomes; D013045:Species Specificity; D014960:X Chromosome; D014998:Y Chromosome
D001973:Bromodeoxyuridine