title: Pharmacokinetics of azlocillin after intramuscular application.
abstract: The first pharmacokinetic data are reported of azlocillin injected intramuscularly to adult probands. The blood serum and urinary levels of azlocillin were determined microbiologically in 8 healthy volunteers after intramuscular injection of 2 grams. Peak serum levels of azlocillin were found by the end of hour 1 after injection, average level was (55.06 +/- 10.25) mg/l. At hour 2 the average level was (33.64 +/- 6.46) mg/l. and at hour 4, (9.47 +/- 1.79) mg/l. The biological half-life was 1.4 hour. In urine, (41.2 +/- 7.7)% of the administered dose was eliminated within 8 hours on average.
mesh_terms: D001390:Azlocillin / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007700:Kinetics; D008297:Male
chemical_list: D001390:Azlocillin