Metabolic effects of long-term arterialization of portal blood.
In nine splenectomized male dogs a splenic artery, -splenic vein shunt was made. Before splenectomy and 3, 6 and 18 months after arterialization of portal blood, different metabolic and endocrine parameters were estimated. Long-term arterialization of portal blood was followed by only insignificant increase of portal vein pressure but a significant drop of pCO2 and increase of pO2 in portal blood was recorded. Simultaneously, a significant decrease of the erythrocyte count, hematocrit value, serum cholesterol and uric acid levels, and a shortening of the T1/2 of insulin and glucagon were found. In contrast, long-term arterialization of portal blood was followed by a significant increase of serum triglycerides, alpha2-globulins, plasma renin activity, cortisol, gastrin and 25-hydroxyvitamin D, and by slight carbohydrate intolerance. No morphological abnormalities in the liver and kidney tissue were found. Data presented in this paper suggest usefulness of a splenic artery-splenic vein shunt in the treatment of some metabolic disorders and of the failing hepatocytes.
D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D001798:Blood Proteins / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs; D004906:Erythrocyte Count; D005934:Glucagon / Q000097:blood; D006207:Half-Life; D006400:Hematocrit; D006728:Hormones / Q000097:blood; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D010100:Oxygen / Q000097:blood; D011168:Portal System / Q000502:physiology; D013156:Splenectomy; D013157:Splenic Artery; D013162:Splenic Vein; D014527:Uric Acid / Q000097:blood
D001798:Blood Proteins; D006728:Hormones; D007328:Insulin; D008055:Lipids; D002245:Carbon Dioxide; D014527:Uric Acid; D005934:Glucagon; D010100:Oxygen