[Effect of vitamins A and E on the structural-functional state of retinal lysosomes].
Vitamins A and E (alpha-tocopheryl-acetate and retinol-palmitate) are studied for their effect on structural and functional state of retina lysosomes. These vitamins are shown to exert a pronounced membrane-tropic effect on lysosomes. Vitamin E in chosen concentrations stabilizes membranes of retina lysosomes both in the in vitro and in vivo experiments. Vitamin A acts on them as a labilizing agent. The mentioned effect of vitamins may be corrected by low-energy radiation of the monochromatic coherent light (lambda = 632.8 nm). It is substantiated experimentally that the stabilizing effect of vitamin E may be intensified in case of the action combined with laser radiation on lysosomes. The labilizing effect of vitamin A on membranes of organelles under study may be weakened by application of laser radiation of low intensities.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002417:Cattle; D006868:Hydrolysis; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000201:enzymology; D014801:Vitamin A / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*; D001616:beta-Galactosidase / Q000378:metabolism; D001617:beta-Glucosidase / Q000378:metabolism
D014801:Vitamin A; D014810:Vitamin E; D000135:Acid Phosphatase; D001617:beta-Glucosidase; D001616:beta-Galactosidase
Deĭstvie vitaminov A i E na strukturno-funktsional'noe sostoianie lizosom setchatoĭ obolochki glaz.