Expression of synaptophysin during postnatal development of the mouse brain.
The expression of the synaptic vesicle membrane protein, synaptophysin, was analyzed during postnatal development of the mouse cerebrum using a quantitative immunoblotting procedure. From birth to adulthood, the relative contents of synaptophysin increased 80-fold, reaching a final level of 3.5 micrograms/mg of total protein. The time course of accumulation suggests that synaptophysin expression is correlated with synaptogenesis. Thus synaptophysin may be used as a reliable marker of nerve terminal differentiation.
D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D003101:Collodion; D007158:Immunologic Techniques; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D013569:Synapses / Q000502:physiology; D013570:Synaptic Membranes / Q000502:physiology; D016708:Synaptophysin
D008565:Membrane Proteins; D016708:Synaptophysin; D003101:Collodion