Unilateral substantia nigra lesions and schedule-induced polydipsia.
The present experiment investigated the effects of unilateral 6-hydroxydopamine lesions of the substantia nigra (SN) on schedule-induced polydipsia (SIP). Lesions were made in either the "dominant" or "non-dominant" hemisphere as defined by an amphetamine rotation test. It was found that unilateral lesions of either the "dominant" or "non-dominant" SN significantly reduced SIP and also significantly impaired somatosensory responsiveness as indicated by the "tactile extinction test." Somatosensory neglect was significantly greater following a lesion in the "dominant" hemisphere than "non-dominant" hemisphere.
D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology; D004292:Dominance, Cerebral; D004327:Drinking Behavior / Q000187:drug effects; D007839:Functional Laterality; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D016627:Oxidopamine; D051381:Rats; D013378:Substantia Nigra / Q000502:physiology*; D013894:Thirst
D006892:Hydroxydopamines; D016627:Oxidopamine; D003913:Dextroamphetamine