Thromboxane A2 (TXA2) formation by washed human platelets under the influence of low and high density lipoproteins from healthy donors.
Low density lipoprotein (LDL) stimulates TXA2 formation (measured as malondialdehyde) in washed human platelets with active cyclooxygenase, whereas high density lipoprotein (HDL) does not show any influence on TXA2 formation in this system. These results support the hypothesis that the proaggregatory action of a high plasma LDL concentration may be mediated by modification in the biosynthesis of eicosanoids. The mode of action of lipoproteins is discussed.
D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008075:Lipoproteins, HDL / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000494:pharmacology*; D008315:Malondialdehyde / Q000032:analysis / Q000378:metabolism; D011450:Prostaglandin Endoperoxides, Synthetic / Q000008:administration & dosage / Q000378:metabolism; D044262:Prostaglandin H2; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology; D011463:Prostaglandins H / Q000008:administration & dosage / Q000378:metabolism; D013928:Thromboxane A2 / Q000096:biosynthesis*
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D011450:Prostaglandin Endoperoxides, Synthetic; D011463:Prostaglandins H; D044262:Prostaglandin H2; D008315:Malondialdehyde; D013928:Thromboxane A2; D011451:Prostaglandin-Endoperoxide Synthases