Effects of intravenous aspirin on prostaglandin synthesis and kidney function in intensive care patients.
The effects of intravenous acetylsalicylic acid (1.0 g bolus) on renal function and prostaglandin synthesis were evaluated in a prospective, controlled study in eight patients in an intensive care unit. Four of these patients had congestive heart failure. Administration of acetylsalicylic acid caused significant antidiuresis (-56%), antinatriuresis (-82%), renin suppression (-26%) and decreased GFR (-41%). All of these changes were completely reversible within 1-2 hours and tended to be more pronounced in the patients with congestive heart failure. Urinary excretion of prostaglandin E2 was depressed profoundly (-93%) and did not return to more than 45% of control 6 h after the administration of acetylsalicylic acid. We conclude that intravenous acetylsalicylic acid affects kidney function in a manner similar to other prostaglandin synthesis inhibitors. Its effects are, however, short-lived. The inhibition of urinary PGE2 excretion outlasts GFR depression, antidiuresis, antinatriuresis and renin suppression by several hours.
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001241:Aspirin / Q000008:administration & dosage* / Q000494:pharmacology; D003422:Critical Care; D015232:Dinoprostone; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D007444:Inulin / Q000652:urine; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D011446:Prospective Studies; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000652:urine; D012083:Renin / Q000097:blood; D013997:Time Factors
D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D011458:Prostaglandins E; D007444:Inulin; D012083:Renin; D015232:Dinoprostone; D001241:Aspirin