[Antiproliferative activity of difluoromethylornithine and the factors decreasing its effectiveness in malignant growth].
The inhibitory effect of difluoromethylornithine (DFMO) synthesized by the authors on the activity of the ornithine decarboxylase (ODC) and proliferation of microbial and mammalian cells in vitro was studied. The in vivo growth of ascite plasmocytoma of solid melanoma B-16 cells in mice was also effectively inhibited by DFMO. But the antiproliferative activity of DFMO in solid tumours was substantially lower. Such a decrease in the antitumour activity may be associated with polyamines released from necrotic areas of solid tumours. As the tumour cells "catch" the vitally important metabolites, their effect inside solid tumours is turned against the tumour cells themselves. The second reason of the decrease in the DFMO activity is adsorption of polyamines on the erythrocyte surface.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001410:Bacillus megaterium / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D000518:Eflornithine; D004926:Escherichia coli / Q000187:drug effects; D008115:Liver Regeneration / Q000187:drug effects; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009952:Ornithine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D065108:Ornithine Decarboxylase Inhibitors; D010954:Plasmacytoma / Q000188:drug therapy; D051381:Rats
D000970:Antineoplastic Agents; D065108:Ornithine Decarboxylase Inhibitors; D009952:Ornithine; D000518:Eflornithine
Izuchenie antiproliferativnoĭ aktivnosti diftormetilornitina i nekotorykh faktorov, snizhaiushchikh ego éffektivnost' pri zlokachestvennom roste.