title: [PLacebo-controlled double blind study of the anti-ischemic efficacy of transdermal depot nitrate].
abstract: Twelve patients with stable angina pectoris were studied in a randomized double blind cross-over placebo-controlled manner utilizing exercise testing and measurement of ST-segment depression before, 2, 6 and 24 hours after application of a transdermal system delivering 5 mg or 10 mg nitroglycerin per day. All testings were performed at a constant work load and exercise time. Significant improvement of ST-segment depression was only seen at 2 hours (5 mg: -45%, 10 mg: -55%) and 6 hours (5 mg: -16%, 10 mg: -31%) but not at 24 hours. The lack of efficacy at 24 hours appears to be due to tolerance.
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004361:Drug Tolerance; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage*; D011897:Random Allocation
chemical_list: D003692:Delayed-Action Preparations; D005996:Nitroglycerin
vernacular_title: Placebo-kontrollierte Doppelblind-Studie zur antiischämischen Wirksamkeit und Wirkdauer von transdermalem Depotnitrat.