Chronic cardiac toxicity after inhalation of 1,1,1-trichloroethane.
Two patients showed evidence of chronic cardiac toxicity after repeated exposure to 1,1,1-trichloroethane. In both cases there was circumstantial evidence of a deterioration after routine anaesthetic use of the related compound halothane. An adolescent boy who sniffed trichloroethane presented with multiple ventricular arrhythmias during tonsillectomy. Follow up showed mild chronic left ventricular impairment. A 54 year old man had repeated industrial exposure to trichloroethane and deteriorated from mild stable cardiac failure to end stage cardiac failure after halothane anaesthesia for herniorrhaphy. Chronic cardiac toxicity is a previously unreported feature of this type of solvent exposure. Related compounds such as halothane may have a toxic interaction after exposure to trichloroethane.
D000293:Adolescent; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000175:diagnosis; D002908:Chronic Disease; D004452:Echocardiography; D006321:Heart / Q000187:drug effects*; D006333:Heart Failure / Q000139:chemically induced / Q000175:diagnosis; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D012997:Solvents / Q000494:pharmacology; D019966:Substance-Related Disorders / Q000150:complications*; D014240:Trichloroethanes / Q000494:pharmacology
D006843:Hydrocarbons, Chlorinated; D012997:Solvents; D014240:Trichloroethanes; C024566:1,1,1-trichloroethane