CO2 challenge of patients with panic disorder.
In an open trial, five of eight panic disorder patients and none of five control subjects panicked after inhalation of two breaths of 35% CO2 and 65% O2; none panicked after placebo. Using 35% CO2 to induce panic is safe, simple, and well tolerated and may provide a valuable laboratory model of panic.
D000280:Administration, Inhalation; D000328:Adult; D001008:Anxiety Disorders / Q000139:chemically induced* / Q000175:diagnosis; D002245:Carbon Dioxide / Q000008:administration & dosage; D005239:Fear; D006801:Humans; D010100:Oxygen / Q000008:administration & dosage; D010200:Panic; D010865:Pilot Projects
D002245:Carbon Dioxide; D010100:Oxygen