Mutagenic evaluation of tolbutamide and glybenclamide on the bone marrow cells of mice.
Mutagenicity of tolbutamide (TB) and glybenclamide (GL) was evaluated in vivo by the micronucleus test (MNT) in mice. Various doses of either TB or GL, as suspension in 1% gum-acacia, were orally administered to the animals, twice, at an interval of 24 h. 6 h after the second treatment, bone-marrow smears were prepared, stained and examined for the occurrence of micronucleated erythrocytes. Animals receiving the vehicle only, served as control. TB only at two higher dose levels induced significant increase in the percentage of micronucleated erythrocytes over that of the control, but GL failed to do so.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D005905:Glyburide / Q000633:toxicity*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D014044:Tolbutamide / Q000633:toxicity*
D009153:Mutagens; D014044:Tolbutamide; D005905:Glyburide