Dry air-induced constriction: effects of pharmacological intervention and temperature.
We studied airway wall temperature (Taw) during dry air challenge of the canine lung periphery. We measured collateral resistance (Rcs) before and after periods of elevated airflow using a wedged bronchoscope technique. As flow rate increased, Taw dropped and postchallenge Rcs rose. A significant negative correlation was found between Taw recorded during challenge and Rcs observed 5 min after challenge. Repetitive dry air challenge produced similar changes in Rcs and Taw. However, responses to warm moist air were significantly lower than consecutive responses to dry air. Taw was significantly lower during dry air challenge than during moist air challenge. Indomethacin (5 mg/kg) and atropine (1 mg/kg) reduced responses to dry airflow challenge. Indomethacin did not affect Taw during the challenge, whereas atropine reduced the fall in Taw. We conclude that temperature correlates negatively with peripheral lung tone 5 min after dry air challenge. This correlation holds under conditions where airflow is increased, air is humidified, or atropine is administered. The dissociation between Taw and physiological response after indomethacin likely reflects a decrease in mediators released during challenge.
D000388:Air; D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001986:Bronchial Spasm / Q000209:etiology; D016861:Cyclooxygenase Inhibitors; D004285:Dogs; D006813:Humidity; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011950:Receptors, Cholinergic / Q000187:drug effects; D013696:Temperature
D016861:Cyclooxygenase Inhibitors; D011950:Receptors, Cholinergic; D001285:Atropine; D007213:Indomethacin