title: Influence on platelet activity and red cell fluidity of epoprostenol and two stable prostacyclin analogues in vitro.
abstract: Not only epoprostenol (prostacyclin, PGI2) but also the two stable prostacyclin analogues CG 4203 (oxacyclic) and CG 4305 (carbacyclic) cause concentration dependent inhibition of thrombocyte function: pseudopod formation and aggregation after stimulation with ADP, collagen and arachidonic acid are inhibited to an extent dependent on dose. ADP-induced aggregation is inhibited 45% by 10 nmol/l epoprostenol 47% by 50 nmol/l CG 4203 and 25% by 50 nmol/l CG 4305. Epoprostenol itself improves red cell fluidity to an extent dependent on concentration, but the two analogues tested show no such effect.
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects* / Q000648:ultrastructure; D003094:Collagen / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology* / Q000031:analogs & derivatives; D004912:Erythrocytes / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects
chemical_list: D001095:Arachidonic Acids; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate; C050548:naxaprostene; C039188:taprostene; D003094:Collagen; D011464:Epoprostenol