[Mitochondrial oxidative phosphorylation in the rat kidney during the perinatal period].
Oxidative metabolism in the developing rat kidney has been studied on isolated mitochondria. An increase of about 50% in state 3 respiration has been observed at birth, using succinate, glutamate, or palmitoyl-L-carnitine as a substrate. The rate of respiration in the presence of 2,4-dinitrophenol was found identical to state 3 respiration in all cases. Cytochrome oxidase activity did not change between the fetal and newborn stages. The increase of mitochondrial respiration revealed here, which is not linked to a modification of the respiratory chain, could be involved in the rise of kidney ATP level and energy charge observed at birth.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D005333:Fetus / Q000378:metabolism; D007668:Kidney / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains
Métabolisme oxydatif mitochondrial dans le rein de rat au cours de la période périnatale.