Erythropoietin levels in heterozygous alpha-thalassemia.
In guinea pig bone marrow cultures with heterozygous alpha-thalassemic serum, 59Fe uptake values are elevated above iron values of cultures with serum of normal subjects. These results show that erythropoietin (EP) activity values in heterozygous alpha-thalassemia are comparable to those previously observed by ourselves in heterozygous beta-thalassemia despite of the different Hb concentration in these thalassemic syndromes. This points to the existence of signals which regulate Ep synthesis independently of Hb levels.
D000293:Adolescent; D000328:Adult; D002648:Child; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D013789:Thalassemia / Q000097:blood* / Q000235:genetics
D004921:Erythropoietin