title: Influence of the neonatal (clomiphene) inhibition of estradiol imprinting on gonadal development and gonadal and thyroid hormone production later in life.
abstract: Treatment of newborn rats with clomiphene citrate during the first 5 days of life gave rise to a marked decrease in body mass and to a still greater decrease in gonadal mass. A decrease was also observed in the testicular diameter of the males. The females showed a 43% increase in their estradiol levels over the control and an increase in the sensitivity to gonadotropins. Thyroxine level, which was also determined in view of the known gonadotropin-thyrotropin overlap, showed no change 6 weeks after pretreatment with clomiphene, while the thyroid gland responded to gonadotropin in the same manner as to thyrotropin.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D002996:Clomiphene / Q000494:pharmacology*; D004964:Estriol / Q000097:blood; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000494:pharmacology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000254:growth & development*; D051381:Rats; D013737:Testis / Q000254:growth & development*; D013974:Thyroxine / Q000096:biosynthesis*
chemical_list: D004965:Estrogen Antagonists; D002996:Clomiphene; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D004964:Estriol; D013974:Thyroxine