Blood mononuclear cells in patients with primary Sjögren's syndrome: production of interleukins, enumeration of interleukin-2 receptors, and DNA synthesis.
Disturbed immunoregulation is considered an essential feature of the pathogenesis in primary Sjögren's syndrome (primary SS). After in vitro stimulation we investigated the interleukin-1 production by blood monocytes, interleukin-2 production by blood T-lymphocytes, the number of IL-2 receptor-bearing blood T-lymphocytes and the blood lymphocyte DNA synthesis in 6 consecutive female patients with primary SS and in 6 female controls. In the patient group we found all the parameters examined within a wider range as compared to the controls. The three patients with reduced interleukin-2 production and low proliferative responses were exclusively characterized by elevated plasma-IgG concentration, positive antinuclear antibodies and rheumatoid factor, and by having circulating immune complexes.
D004247:DNA / Q000096:biosynthesis*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D009000:Monocytes / Q000276:immunology*; D011971:Receptors, Immunologic / Q000032:analysis*; D015375:Receptors, Interleukin-2; D012859:Sjogren's Syndrome / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D007375:Interleukin-1; D007376:Interleukin-2; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D004247:DNA