title: In-vitro susceptibility of oral streptococci to pristinamycin.
abstract: The inhibitory activity of pristinamycin against oral streptococci was compared with that of amoxycillin, erythromycin and vancomycin. Minimum inhibitory concentrations (MICs) of pristinamycin ranged from 0.03-1 mg/l (mode 0.25 mg/l), similar to those for amoxycillin. Erythromycin had a mode MIC of 0.06 mg/l and vancomycin, the least active, 1 mg/l. However, in killing curve experiments to compare the bactericidal activities of pristinamycin and erythromycin against several strains of oral streptococci, pristinamycin was substantially more active, consistently producing a rapid decrease in viable count during the first few hours of incubation. Pristinamycin may prove to be of value for the prophylaxis of post-dental extraction bacteraemia.
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000382:microbiology; D010455:Peptides / Q000494:pharmacology; D013291:Streptococcus / Q000187:drug effects*; D014640:Vancomycin / Q000494:pharmacology; D014769:Virginiamycin
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; D014769:Virginiamycin; D004917:Erythromycin; D014640:Vancomycin; D000658:Amoxicillin