[Changes in hepatic enzyme activities of drug metabolism in rats exposed to normobaric oxygen].
Exposure of adult rats to 1 ATA O2 during 55 hrs. decreased cytochrome P-450 in the homogenate supernatant of livers. Hepatic microsomal epoxide hydrolase and P-nitrophenol UDP-glucuronosyltransferase activities were also decreased. Histological and ultrastructural liver studies showed tissular and cellular modifications suggestive of hepatocyte hypoxia.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004851:Epoxide Hydrolases / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010100:Oxygen / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D014453:Glucuronosyltransferase; D004851:Epoxide Hydrolases; D010100:Oxygen
Modifications des activités enzymatiques hépatiques du métabolisme des médicaments chez le rat exposé à l'oxygène normobare.