[Anosmia or hyposmia after long-term oral administration of tegafur--improved anosmia].
Seventeen patients who manifested anosmia or hyposmia after long-oral administration of Tegafur (FT-207) in postoperative chemotherapy for cancer were followed up. Anosmia improved in 9 of 17 patients (52.9%), and the recovery period was between 3 and 42 months after the manifestation, and between 1 and 35 months after discontinuation of FT-207. Rhinoscopy and radiography revealed no abnormal findings in the nasal septum, rima oflactoria, concha nasalis media, sinus ethmoidales, etc. As it took a long time to recover from these signs and symptoms, they were presumed to be due to reversible neurological anosmia or hyposmia.
D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy / Q000503:physiopathology*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000139:chemically induced / Q000503:physiopathology*; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000503:physiopathology*; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000503:physiopathology*; D005641:Tegafur / Q000008:administration & dosage / Q000009:adverse effects*
D005641:Tegafur