Metabolic recovery following temporary regional myocardial ischemia in the rat.
The restoration of the cardiac ATP content after an ischemic insult takes a long period of time. Ribose, via stimulation of adenine nucleotide biosynthesis, accelerated the replenishment of the adenine nucleotide pool in the heart, in the kidney, however, it had no effect. In the myocardium, the ribose-mediated restoration of the adenine nucleotide content was dependent on the duration of the previous ischemic period and was not influenced by the beta-receptor blocker atenolol.
D000208:Acute Disease; D000227:Adenine Nucleotides / Q000096:biosynthesis; D000255:Adenosine Triphosphate / Q000096:biosynthesis*; D000818:Animals; D001262:Atenolol / Q000494:pharmacology; D003327:Coronary Disease / Q000378:metabolism*; D005260:Female; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012266:Ribose / Q000494:pharmacology
D000227:Adenine Nucleotides; D001262:Atenolol; D012266:Ribose; D000255:Adenosine Triphosphate