Synaptophysin--an immuno-histochemical marker for childhood neuroblastoma.
Synaptophysin, an integral membrane glycoprotein of presynaptic vesicles, was tested as an immuno-histochemical marker for childhood neuroblastoma. Synaptophysin immuno-reactivity was found in all neuroblastomas (6/6), but not in the other small round-cell tumors to be considered in its differential diagnosis. Thus, rhabdomyosarcomas (0/5), lymphomas (0/4), or Ewing's sarcomas (0/2) were negative for synaptophysin. The results suggest that synaptophysin is a useful marker for neuroblastoma, and it should belong to the marker panel used for the differential diagnosis of small round-cell tumors of childhood.
D000328:Adult; D002648:Child; D002675:Child, Preschool; D006651:Histocytochemistry; D006801:Humans; D007223:Infant; D008297:Male; D008565:Membrane Proteins / Q000032:analysis* / Q000276:immunology; D009447:Neuroblastoma / Q000032:analysis* / Q000175:diagnosis; D016708:Synaptophysin
D008565:Membrane Proteins; D016708:Synaptophysin