The metabolism of o-fluoroaniline by rats, rabbits and marmosets.
o-Fluoroaniline is rapidly metabolized and excreted in rats, rabbits and marmosets. Following a single oral dose of 14C-fluoroaniline of about 20 mg/kg, more than 80% of the dose is excreted in 0-24 h, the urine being the major route of excretion for all three species. For all three species, 4-amino-3-fluorophenyl is a major metabolite, conjugated at oxygen with either sulphate or glucuronic acid. 4-Acetylamino-3-fluorophenyl sulphate or glucuronide are also significant metabolites. An h.p.l.c. method with electrochemical detection was developed for monitoring exposure of plant workers to o-fluoroaniline, based on 4-amino-3-fluorophenyl sulphate.
D000814:Aniline Compounds / Q000378:metabolism* / Q000652:urine; D000818:Animals; D001711:Biotransformation; D002143:Callitrichinae; D004563:Electrochemistry; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D000814:Aniline Compounds; C043455:4-fluoroaniline