Effect of various inducing agents on bacteriocin (klebocin) production by Klebsiella pneumoniae.
The influence of various inducing agents on growth, synthesis and release of klebocin by Klebsiella pneumoniae was studied. A significant level of klebocin was detected only after induction. The highest level of klebocin was achieved with mitomycin C followed by rifampicin and polymyxin B. Chloramphenicol and UV irradiation did not show any effect on klebocin production. Maximum klebocin release occurred after 8 h of induction with all the agents. Concentration of mitomycin C did not show any significant effect on klebocin production.
D001430:Bacteriocins / Q000096:biosynthesis*; D002701:Chloramphenicol / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D011112:Polymyxin B / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D014466:Ultraviolet Rays
D001430:Bacteriocins; D008937:Mitomycins; C019447:klebocin; D016685:Mitomycin; D002701:Chloramphenicol; D011112:Polymyxin B; D012293:Rifampin