title: Evaluation of routine anti-HBc screening of volunteer blood donors: a questionable surrogate test for non-A, non-B hepatitis.
abstract: Routine antibody to hepatitis B core antigen (anti-HBc) screening, recommended as a surrogate test to identify potential carriers of non-A, non-B hepatitis, was evaluated on 22,346 blood donors using currently available enzyme immunoassay (EIA) reagents. Of the 2 percent found reactive, the majority had cutoff-to-sample absorbance ratios less than 2.0 and less than one-half had anti-HBc when tested by a radioimmunoassay (RIA) method. Only one of 2877 units donated previously by the reactive donors was implicated in a transfusion associated hepatitis case. These results raise questions about the use of currently available anti-HBc reagents as a surrogate test for non-A, non-B hepatitis.
mesh_terms: D001782:Blood Donors; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D006526:Hepatitis C / Q000276:immunology*; D006525:Hepatitis, Viral, Human / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques
chemical_list: D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens