One heavy chain variable region gene segment subfamily in the BALB/c mouse contains 500-1000 or more members.
Nucleic acid hybridization studies suggest that 500-1000 or more heavy chain variable (VH) gene segments related to one VH gene segment (J558) are present in the genome of the BALB/c mouse. The implications of this result regarding the overall size, sequence organization, and evolution of the mouse family of VH gene segments are discussed.
D000818:Animals; D005819:Genetic Markers; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D008433:Mathematics; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D011995:Recombination, Genetic; D013696:Temperature
D005819:Genetic Markers; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region