[Comparative clinical study of tiaprofenic acid and lysine acetylsalicylate in aged osteoarthrosis patients].
Thirty elderly patients (mean age 74) with osteoarthritis effecting various joints were treated with an oral suspension of either tiaprofenic acid (TA) (600 mg per diem b.i.d.) or lysine acetyl salicylate (1800 mg per diem b.i.d.) for 3-6 months in an open randomized experimental study. The parameters of efficacy assessed were pain at rest and under load, stiffness, ability to perform a pre-selected daily exercise and joint movements hampered by the disease. Blood flow, liver and kidney function and side effects were examined on a monthly basis. The tiaprofenic acid proved more effective in reducing pain and aiding functional recovery and was also better tolerated, especially at gastrointestinal level. Nine patients under lysine acetyl salicylate and 2 under tiaprofenic acid were forced to suspend treatment due to pyrosis, epigastralgia ed dyspepsia.
D000284:Administration, Oral; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D001241:Aspirin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001847:Bone Diseases / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000188:drug therapy*; D008239:Lysine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D011422:Propionates / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation
D000700:Analgesics; D011422:Propionates; C021270:tiaprofenic acid; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate
Studio clinico di confronto tra acido tiaprofenico e acetilsalicilato di lisina in pazienti anziani osteoartrosici.