Ventricular arrhythmias during treatment for acute asthma.
A double-blind, randomized study was performed to determine the occurrence of ventricular arrhythmias in acute asthma patients treated with epinephrine, aminophylline, or both in combination. Sixty patients were studied with Holter monitoring during the 90-minute study period. There was no statistical difference among the study groups in frequency or grade of ventricular arrhythmia. Combination treatment of acute asthma with these drugs is as safe as treatment with either alone.
D000328:Adult; D000628:Aminophylline / Q000009:adverse effects* / Q000097:blood; D000704:Analysis of Variance; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001249:Asthma / Q000188:drug therapy*; D002245:Carbon Dioxide / Q000097:blood; D004311:Double-Blind Method; D004338:Drug Combinations; D004630:Emergencies; D004837:Epinephrine / Q000009:adverse effects*; D005260:Female; D006352:Heart Ventricles; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011897:Random Allocation; D012306:Risk
D004338:Drug Combinations; D002245:Carbon Dioxide; D000628:Aminophylline; D010100:Oxygen; D004837:Epinephrine