Effect of acetyl salicylic acid on production and action of leukocyte-derived interferons.
Although acetylsalicylic acid does not itself induce interferon, acetylsalicylic acid was found to significantly enhance the production of both human alpha interferon and human gamma interferon when added with the appropriate inducers to cultures of human peripheral blood mononuclear cells. The mechanisms associated with this effect were investigated.
D001241:Aspirin / Q000494:pharmacology*; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000096:biosynthesis*; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism
D007370:Interferon Type I; D007371:Interferon-gamma; D001241:Aspirin