title: Susceptibility of tamarin (Saguinus labiatus) red blood cell membrane lipids to oxidative stress: implications for wasting marmoset syndrome.
abstract: Captive Callitrichids frequently suffer a fatal wasting disease, wasting marmoset syndrome (WMS), of unexplained cause. This paper describes studies on the erythrocytes from animals in a breeding colony of tamarins (Saguinus labiatus), in which deaths from anaemia and wasting were occurring, to seek evidence for biochemical changes which could lead to oxidative damage and premature cell lysis. In only one animal of 33 studied did the red blood cell lipids show an increased susceptibility to oxidative damage. This animal, with some degree of certainty, could be diagnosed as having WMS. It was concluded that evidence for a primary deficiency of antioxidants as a cause of unexplained deaths, or WMS, in the colony could not at present be substantiated.
mesh_terms: D000818:Animals; D002143:Callitrichinae / Q000097:blood*; D004910:Erythrocyte Membrane / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood; D006461:Hemolysis; D006861:Hydrogen Peroxide; D008054:Lipid Peroxides / Q000378:metabolism; D008563:Membrane Lipids / Q000097:blood; D008992:Monkey Diseases / Q000097:blood* / Q000188:drug therapy; D010084:Oxidation-Reduction; D012643:Selenium / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D008054:Lipid Peroxides; D008563:Membrane Lipids; D014810:Vitamin E; D006861:Hydrogen Peroxide; D005979:Glutathione Peroxidase; D012643:Selenium