Twenty-one-month evaluation of misoprostol for carcinogenicity in CD-1 mice.
Misoprostol, a synthetic prostaglandin E1 methyl ester analogue with anti-ulcer potential, was evaluated for its carcinogenic potential in CD-1 strain mice. The compound was given daily by gavage at 160, 1,600, and 16,000 micrograms/kg for 21 months. Necropsies were done on all animals and the incidences of non-neoplastic and neoplastic changes analyzed for significance by life table methods. The only statistically significant non-neoplastic compound-related findings were epithelial hyperplasia and hyperkeratosis of the gastric mucosa and hyperostosis of bone in the marrow cavity of sternebrae and femurs. The changes in the gastric epithelium are characteristic of some prostaglandins and were expected. The bone hyperostosis was associated with misoprostol in high dosages, and was considered unique to the mouse. Other non-neoplastic findings were typical of known spontaneous conditions in mice. The most frequent neoplasm was the hepatocellular adenoma followed by lymphosarcoma, lung alveolar carcinoma, and Harderian gland adenoma. Several proliferative lesions of the duodenum were considered to be spontaneous. These were focal avillous hyperplasia, focal atypical hyperplasia, and junctional polyp. There was no evidence that misoprostol is carcinogenic for CD-1 mice.
D000527:Alprostadil / Q000031:analogs & derivatives* / Q000633:toxicity; D000818:Animals; D000897:Anti-Ulcer Agents / Q000633:toxicity*; D002273:Carcinogens; D005260:Female; D008297:Male; D051379:Mice; D016595:Misoprostol; D009374:Neoplasms, Experimental / Q000473:pathology*; D009928:Organ Specificity
D000897:Anti-Ulcer Agents; D002273:Carcinogens; D016595:Misoprostol; D000527:Alprostadil