[Release of plasminogen activator by SIN-1].
SIN-1--a pharmacologically active metabolite of the vasodilating agent molsidomine--caused an increase in plasminogen activator release of about 50 per cent at a final concentration of 10(-7) mol/l on perfusion of isolated pig ears. An increase in SIN-1 concentration did not produce a further increase in activator release. The released activator is of the tissue-type. After repeated perfusion of the isolated pig ear with SIN-1 no further significant increase in plasminogen activator release occurred.
D000818:Animals; D008981:Molsidomine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013552:Swine; D010959:Tissue Plasminogen Activator / Q000378:metabolism*
C002385:linsidomine; D008981:Molsidomine; D010959:Tissue Plasminogen Activator
Libération de l'activateur du plasminogène par le SIN-1.