title: Indication for weak mutagenicity of the organophosphorus insecticide dimethoate in Drosophila melanogaster.
abstract: The organophosphorus insecticide dimethoate was tested for induction of genetic damage in male germ cells of Drosophila melanogaster. Sex-linked recessive lethals, sex-chromosome loss and non-disjunction induction were studied following different routes of administration: adult feeding, injection and larval feeding. Our results show that, after injection, dimethoate induces a slight but significant increase in the frequency of point mutations.
mesh_terms: D000818:Animals; D002872:Chromosome Deletion; D004117:Dimethoate / Q000008:administration & dosage / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000254:growth & development; D005260:Female; D005804:Genes, Lethal / Q000187:drug effects; D005808:Genes, Recessive / Q000187:drug effects; D007814:Larva; D008297:Male; D009630:Nondisjunction, Genetic / Q000187:drug effects; D012730:Sex Chromosomes / Q000187:drug effects
chemical_list: D004117:Dimethoate