Aspirin sensitive asthma and arachidonic acid transformation.
Inhibition by nonsteroidal antiinflammatory drugs of cyclooxygenase appears to be the basic mechanism operating in aspirin-sensitive asthma. Evidence in favor of this theory is presented. We also discuss biochemical consequences of blockade of cyclooxygenase for clinical symptomatology, prevention and treatment of aspirin-sensitive asthma.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001095:Arachidonic Acids / Q000378:metabolism*; D001241:Aspirin / Q000494:pharmacology*; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D016861:Cyclooxygenase Inhibitors; D004342:Drug Hypersensitivity / Q000503:physiopathology; D006801:Humans
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D001241:Aspirin