title: [Pulsatile long-term gonadotropin-releasing hormone (GnRH) therapy in the male: natural induction of puberty in a 20-year-old boy].
abstract: Successful induction of puberty by means of a pulsatile long-term therapy with GnRH--the variant closest to nature--can be performed on an outpatient basis without changing habits and lifestyle, as was demonstrated clinically and biochemically in a 20-year-old previously untreated boy with hypothalamic hypogonadism of unknown etiology. Unusual in this patient's course was the slow--and modest--increase in plasma FSH levels. Evidence that puberty did not occur spontaneously but was in fact due to treatment was gained from gonadotropin profiling by night and day before and after therapy withdrawal.
mesh_terms: D000328:Adult; D004341:Drug Evaluation; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000188:drug therapy*; D007260:Infusion Pumps; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011628:Puberty, Delayed / Q000097:blood / Q000188:drug therapy*; D013739:Testosterone / Q000097:blood; D013997:Time Factors
chemical_list: D006065:Gonadotropins, Pituitary; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
vernacular_title: Pulsatile Gonadotropin-Releasing-Hormon (GnRH)-Langzeittherapie beim männlichen Individuum: "natürliche" Pubertätsinduktion bei einem 20jährigen Knaben.