Comparison of clonidine and lithium in the treatment of mania.
The authors compared the antimanic effects of clonidine with lithium carbonate in a double-blind crossover design with 24 volunteers. Lithium was observed to be more effective than clonidine. Some patients reported experiencing hypotension (N=8) and depression (N=7) while taking clonidine.
D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D002986:Clinical Trials as Topic; D003000:Clonidine / Q000009:adverse effects / Q000627:therapeutic use*; D003863:Depression / Q000139:chemically induced; D004311:Double-Blind Method; D006801:Humans; D007024:Hypotension, Orthostatic / Q000139:chemically induced; D008094:Lithium / Q000009:adverse effects / Q000627:therapeutic use*; D016651:Lithium Carbonate; D008297:Male; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales
D016651:Lithium Carbonate; D008094:Lithium; D003000:Clonidine