[Value of cyclofenil in the inhibition of lactation. Efficacy compared to bromocriptine].
The inhibitory effects of cyclofenil and bromocriptine on lactation as well as FSH, prolactin and estradiol levels have been compared in control and treated females. The clinical activity of cyclofenil was lower than that of bromocriptine but was virtually free of side-effects. Cyclofenil and bromocriptine only presented similar hormonal effects at the 20th day ; this suggests that the mechanism of action of cyclofenil is more linked to secondary increases in estrogen levels than to a primary effect. Cyclofenil is of particular value in cases of vascular hypersensitivity yo ergot derivatives and for toxemic patients treated with beta-blockers.
D000328:Adult; D001940:Breast / Q000187:drug effects; D001971:Bromocriptine / Q000009:adverse effects / Q000494:pharmacology*; D003408:Cresols / Q000494:pharmacology*; D003506:Cyclofenil / Q000009:adverse effects / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D007774:Lactation / Q000187:drug effects*; D008893:Milk Ejection / Q000187:drug effects; D011247:Pregnancy; D011388:Prolactin / Q000097:blood
D003408:Cresols; D006728:Hormones; D001971:Bromocriptine; D004958:Estradiol; D011388:Prolactin; D005640:Follicle Stimulating Hormone; D003506:Cyclofenil
Intérêt du cyclofénil dans l'inhibition de la lactation. Efficacité comparée à celle de la bromocriptine.