Stimulation of synapsin I phosphorylation in synaptosomes by convulsants.
Pentylenetetrazole markedly enhanced synapsin I (previously referred to as protein I) phosphorylation and synaptosomal uptake of Ca2+. Picrotoxin and strychnine sulfate caused a slight increase in the phosphorylation and no significant increase in Ca2+ uptake. The data indicate that pentylenetetrazole appears to influence this process.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D003292:Convulsants / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains; D016704:Synapsins; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
D003292:Convulsants; D009419:Nerve Tissue Proteins; D016704:Synapsins; D002118:Calcium