Inductions of ornithine decarboxylase and DNA synthesis in rat stomach mucosa by 1-nitrosoindole-3-acetonitrile.
Administration of 1-nitrosoindole-3-acetonitrile (NIAN) at doses of 40 to 300 mg/kg body weight by gastric intubation to male F344 rats induced up to 100-fold increase in ornithine decarboxylase activity with a maximum after 24 hr and up to 10-fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa of the stomach. These results suggest that NIAN has potential tumor-promoting activity in carcinogenesis in the glandular stomach.
D000097:Acetonitriles / Q000494:pharmacology*; D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D004790:Enzyme Induction; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D051381:Rats; D013268:Stimulation, Chemical
D000097:Acetonitriles; D004247:DNA; C053072:1-nitrosoindole-3-acetonitrile; D009955:Ornithine Decarboxylase