[Hemodynamic effects of an osmotic bolus for the reversible opening of the blood-brain barrier].
Reversible opening of the blood-brain barrier before administration of watersoluble cytoreductive agents constitutes a new tool in the treatment of central nervous malignancies. In this study a volume of 172 ml mannitol 25% has been injected into one of the cerebral arteries within 30 seconds. 5 minutes later the osmolality had augmented from 286 to 303 mosmol/kg and the plasma volume by 15%. The hemodynamic measurements--cardiac index (+47%), heart rate (+7%), LVSWI (+50%), systemic vascular resistance (-20%) and blood volume (+15%)--indicate a biphasic response with early fall in SVR followed by a rise in cardiac performance which is independent of the preload.
D000328:Adult; D000970:Antineoplastic Agents / Q000378:metabolism / Q000627:therapeutic use*; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008353:Mannitol / Q000008:administration & dosage*; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009994:Osmolar Concentration
D000970:Antineoplastic Agents; D008353:Mannitol; D003520:Cyclophosphamide; D008727:Methotrexate
Hämodynamische Auswirkung eines osmotischen Bolus zur reversiblen Eröffnung der Bluthirnschranke.