[Proteins induced by the double-stranded interferon inducer poly(I).poly(C)].
The possible pathways for realization of antiviral activity of interferon inducer poly (I).poly(C) have been studied. The stimulating effect of interferon inducer on the net protein synthesis in human M19 fibroblasts has been demonstrated. Compositions of the specific proteins induced by poly(I).poly(C) or interferon in human M19 fibroblasts and in monkey cells 4647 have been analyzed by electrophoresis technique. The data obtained suggest the existence of common gene products for interferon and ds-inducer. The ds-inducer requires the synthesis of lesser amounts of proteins for realization of its biological activity as compared with interferon.
D000818:Animals; D002460:Cell Line; D004591:Electrophoresis, Polyacrylamide Gel; D000882:Haplorhini; D006801:Humans; D007369:Interferon Inducers; D007370:Interferon Type I / Q000494:pharmacology; D008970:Molecular Weight; D011070:Poly I-C / Q000494:pharmacology*; D014176:Protein Biosynthesis
D007369:Interferon Inducers; D007370:Interferon Type I; D011070:Poly I-C
Belki, indutsiruemye dvuspiral'nym induktorom interferona poli(I).poli(C).