title: Effects of droxicam on in vivo prostaglandin synthesis and ex vivo platelet aggregation.
abstract: Droxicam, similar to piroxicam, inhibits in vivo renal synthesis of PGF2 alpha. This study was performed in rats; droxicam and piroxicam were administered orally at doses of 0.5, 1.2 and 8 mg/kg. Inhibitory activity of the two compounds was similar (40-60%) but showed no dose-effect relationship. Maximum inhibition was obtained with the 1 mg/kg dosage. In dogs droxicam has shown a clear inhibitory effect on arachidonic acid induced ex vivo platelet aggregation. Droxicam was administered orally at a dose of 2 mg/kg. Maximum inhibition (-40%) was achieved 24 hr post-administration and the effect was sustained up to 72 hr (-23%).
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000652:urine; D015237:Dinoprost; D004285:Dogs; D007668:Kidney / Q000378:metabolism; D008297:Male; D010894:Piroxicam / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D011448:Prostaglandin Antagonists; D011460:Prostaglandins F / Q000096:biosynthesis* / Q000652:urine; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001095:Arachidonic Acids; D011448:Prostaglandin Antagonists; D011460:Prostaglandins F; D011725:Pyridines; D010894:Piroxicam; D016718:Arachidonic Acid; D015237:Dinoprost; C049073:droxicam