Microinjection of transforming ras protein induces c-fos expression.
Microinjection of p21ras induced c-fos protein accumulation in three types of 3T3 cells. The induction was rapid and efficient and persisted for many hours. In addition, anti-ras antibody dramatically reduced c-fos accumulation after serum stimulation of injected cells. However, cells which expressed p21ras continuously did not maintain a high level of c-fos expression.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D007700:Kinetics; D051379:Mice; D015689:Oncogene Protein p21(ras); D009856:Oncogene Proteins, Viral / Q000008:administration & dosage / Q000235:genetics*; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000008:administration & dosage / Q000235:genetics*; D016760:Proto-Oncogene Proteins c-fos; D016283:Proto-Oncogene Proteins p21(ras)
D009856:Oncogene Proteins, Viral; D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D015689:Oncogene Protein p21(ras); D016283:Proto-Oncogene Proteins p21(ras)