title: Studies on 1,2,3-triazole derivatives as potential inhibitors of the cyclo-oxygenase.
abstract: A number of novel alpha-[4-substituted-(1,2,3-triazole)]propionates have been prepared and tested as inhibitors of arachidonic acid-induced malondialdehyde formation in human platelets. The obtained products confirmed previous structure-activity relationships. Some of them showed moderate inhibitory activity.
mesh_terms: D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D016861:Cyclooxygenase Inhibitors; D006801:Humans; D066298:In Vitro Techniques; D008315:Malondialdehyde / Q000378:metabolism; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D014230:Triazoles; D016718:Arachidonic Acid; D008315:Malondialdehyde