Expression of HLA-DR antigens by thyroid cells: the effect of Graves' IgG.
We have investigated factors which influence HLA-DR expression on thyroid cells. While bTSH (100 mU/ml) did not enhance HLA-DR expression, it increased when brought about by IFN-gamma. Graves' IgG showed a dose-dependent (0.1-2 mg/ml) increase in DR expression and at a concentration of 2 mg/ml prolonged the time for which DR was expressed. The pathway of DR induction by Graves' IgG apparently differs from that by IFN-gamma. The humoral response in Graves' disease, by inducing DR expression, may be instrumental in propagating thyroid specific autoimmunity.
D001323:Autoantibodies / Q000276:immunology*; D006111:Graves Disease / Q000276:immunology*; D006681:HLA-D Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D011989:Receptors, Thyrotropin / Q000276:immunology*; D013961:Thyroid Gland / Q000166:cytology / Q000276:immunology*; D013972:Thyrotropin / Q000494:pharmacology
D001323:Autoantibodies; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D011989:Receptors, Thyrotropin; D007371:Interferon-gamma; D013972:Thyrotropin