Heat-sensitivity and the immune response of a methylcholanthrene-induced tumor.
Our results indicate that this methylcholanthrene (MCA)-induced tumor is immunogenic and that its heat-sensitivity is linked to the immune response of the host. Stimulation or reduction of the latter caused a corresponding change in the former. A therapeutic heat-dose failed to protect a majority of the treated mice against a second tumor challenge.
D000818:Animals; D005260:Female; D005976:Glutaral / Q000494:pharmacology; D006979:Hyperthermia, Induced; D008748:Methylcholanthrene; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology* / Q000628:therapy
D008748:Methylcholanthrene; D005976:Glutaral