title: Teratogenesis of dexamethasone and preventive effect of vitamin B12.
abstract: Ddy mice which were treated with 0.32 mg of dexamethasone were used. Vitamin B12 was injected subcutaneously into the animals from the 10th day to the 13th day with a dosage of 0.1r, 1r, or 10r. The rate of incidence of cleft palate was decreased to 77.0% in the 0.1r group, 58.1% in the 1r group and 67.9% in the 10r group as compared to the control value of 88.5%.
mesh_terms: D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced / Q000517:prevention & control*; D003907:Dexamethasone / Q000009:adverse effects; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D013723:Teratogens; D013997:Time Factors; D014805:Vitamin B 12 / Q000627:therapeutic use*
chemical_list: D013723:Teratogens; D003907:Dexamethasone; D014805:Vitamin B 12