Reversal by L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS), a L-norepinephrine precursor of reserpine- or tetrabenazine-induced hypothermia.
The effects of L-threo-DOPS on the hypothermia and the decrease of brain norepinephrine (NE) concentration in the mouse pretreated with reserpine or tetrabenazine were studied. Reserpine (5 mg/kg, i.p.) or tetrabenazine (40 mg/kg, i.p.) produced a significant decrease in body temperature. The i.p. injection of L-threo-DOPS (100, 200 and 400 mg/kg) reversed these hypothermia in a dose-dependent manner. These hypothermia were also antagonized by the i.c. injection of NE (5 micrograms/mouse). Both reserpine and tetrabenazine markedly decreased the brain content of NE, and L-threo-DOPS (400 mg/kg, i.p.) recovered it. These results suggested that L-threo-DOPS would reverse the reserpine- or tetrabenazine-induced hypothermia at least in part by the formation of NE in the central nervous system.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001921:Brain; D001923:Brain Chemistry / Q000187:drug effects; D015103:Droxidopa / Q000494:pharmacology*; D007267:Injections; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology; D012110:Reserpine / Q000037:antagonists & inhibitors*; D012694:Serine / Q000031:analogs & derivatives*; D013747:Tetrabenazine / Q000037:antagonists & inhibitors*; D013997:Time Factors
D012694:Serine; D012110:Reserpine; D015103:Droxidopa; D009638:Norepinephrine; D013747:Tetrabenazine