title: Mantle zone lymphoma with central nervous system involvement.
abstract: A 68-year-old man with a 7-year history of lymphocytosis and lymphadenopathy is described. Accelerated disease, indicated by bilateral optic nerve and cerebrospinal fluid involvement, prompted thorough histologic and immunologic assessment. Although initially believed to have chronic lymphocytic leukemia (CLL), results showed mantle zone lymphoma (MZL) with central nervous system (CNS) involvement. The authors believe that this represents the first case of MZL with CNS involvement.
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000276:immunology / Q000473:pathology*; D003390:Cranial Nerve Neoplasms / Q000473:pathology; D003937:Diagnosis, Differential; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008223:Lymphoma / Q000276:immunology / Q000473:pathology*; D008297:Male; D009901:Optic Nerve Diseases / Q000473:pathology; D013120:Spinal Cord Neoplasms / Q000276:immunology / Q000473:pathology*
chemical_list: D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains