Severe sodium restriction alone and with potassium supplementation does not alter blood lipoproteins in essential hypertension.
Seventeen 50-year-old men, previously untreated and all with mild to moderate essential hypertension, were given a low sodium diet for 2 weeks. During the second week, the diet was supplemented with potassium. Urinary excretion of Na+ decreased from 201 +/- 11 to 24 +/- 5 and 19 +/- 4 mmol 24 h-1, respectively, after 1 and 2 weeks (means +/- SE) while the urinary Na+: K+ ratio changed from 2:1 to 1:4 and 1:11. Despite significant changes in blood pressure, body weight, serum electrolytes, sympathetic noradrenergic tone, haemoglobin concentration and haematocrit, no significant change appeared in serum total cholesterol, HDL-cholesterol or triglycerides. Thus, low sodium diet alone and combined with potassium supplementation seems neutral to blood lipoproteins in the treatment of essential hypertension.
D000328:Adult; D001794:Blood Pressure; D001835:Body Weight; D002395:Catecholamines / Q000097:blood; D004039:Diet, Sodium-Restricted; D004573:Electrolytes / Q000378:metabolism; D006339:Heart Rate; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D011188:Potassium / Q000494:pharmacology*
D002395:Catecholamines; D004573:Electrolytes; D006454:Hemoglobins; D008074:Lipoproteins; D011188:Potassium