The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin.
A novel nonapeptide with neurotensin-like immunoreactivity was isolated from pepsin-treated human plasma by dialysis, ion-exchange chromatography and high performance reversed-phase liquid chromatography. The amino acid sequence was determined by automated gas-phase sequence analysis as Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu. Sequence homology with human serum albumin and with the biologically active peptides neurotensin and angiotensin is demonstrated. The name proposed for this peptide is kinetensin.
D000595:Amino Acid Sequence; D000803:Angiotensin I / Q000032:analysis*; D000809:Angiotensins / Q000032:analysis*; D000818:Animals; D002417:Cattle; D002645:Chickens; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008832:Microchemistry; D009496:Neurotensin / Q000032:analysis*; D009842:Oligopeptides / Q000032:analysis*; D010434:Pepsin A / Q000378:metabolism*; D010446:Peptide Fragments / Q000032:analysis; D010455:Peptides; D012709:Serum Albumin / Q000032:analysis*; D013552:Swine; D014981:Xenopus; D029867:Xenopus Proteins
D000809:Angiotensins; D009842:Oligopeptides; D010446:Peptide Fragments; D010455:Peptides; D012709:Serum Albumin; D029867:Xenopus Proteins; C042090:neuromedin N; C048812:kinetensin; D009496:Neurotensin; C016832:xenopsin; C037243:neurotensin-related hexapeptide; D000803:Angiotensin I; D010434:Pepsin A