title: [Antiviral and immunostimulating effect of maleic anhydride copolymers in experimental neuroviral infections].
abstract: The virus-inhibiting and immunostimulating activity of Soviet preparations, maleic anhydride copolymers, was demonstrated in alpha-, flavi-, and bunyavirus infections. Positive results were obtained in subcutaneous and intraperitoneal inoculations of the preparations used in prophylactic and therapeutic-prophylactic schedules. Stimulation of vaccination immunity was observed after combined use of copolymers and the vaccine against Eastern equine encephalomyelitis.
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004663:Encephalitis Virus, Eastern Equine / Q000276:immunology; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D004683:Encephalomyelitis, Equine / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D005663:Furans / Q000627:therapeutic use*; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000276:immunology; D006479:Hemorrhagic Fever, Crimean / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D007109:Immunity / Q000187:drug effects; D008299:Maleic Anhydrides / Q000627:therapeutic use*; D051379:Mice; D011108:Polymers / Q000627:therapeutic use*; D014765:Viral Vaccines / Q000627:therapeutic use
chemical_list: D000276:Adjuvants, Immunologic; D000998:Antiviral Agents; D005663:Furans; D008299:Maleic Anhydrides; D011108:Polymers; D014765:Viral Vaccines
vernacular_title: Protivovirusnyĭ i immunostimuliruiushchiĭ éffekt sopolimerov maleinovogo angidrida pri éksperimental'nykh neĭrovirusnykh infektsiiakh.