Cause and prevention of mafosfamide-induced venous pain.
An experimental rat model for the study of venous pain induced by 4-hydroxy-cyclophosphamide (4-OH-CP) derivatives was developed and validated. Using various metabolites and chemical variants of 4-OH-CP it was found that pain induction was independent from the compound's alkylating activity but possibly related to the spontaneous generation of minute amounts of acrolein from the 4-OH-CP molecule. Accordingly, the pain could be prevented by the addition of thiol compounds such as mesna or N-acetyl-cysteine.
D000111:Acetylcysteine / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000633:toxicity; D015080:Mesna / Q000494:pharmacology; D010146:Pain / Q000209:etiology* / Q000517:prevention & control; D051381:Rats; D014680:Veins / Q000187:drug effects*
D000970:Antineoplastic Agents; C048341:mafosfamide; D003520:Cyclophosphamide; D015080:Mesna; D000111:Acetylcysteine