title: Metabolic and immune effects of dietary arginine supplementation after burn.
abstract: The effect of supplemental dietary arginine on metabolism and immunity was studied in 36 burned guinea pigs (30% of total body surface area) with previously placed catheter gastrostomies. The animals were randomized into four groups. After an initial three-day adaptation period, all groups received continuous isonitrogenous, isocaloric (175 kcal [735 kJ]/kg/d), and isovolemic intragastric tube feedings until postburn day (PBD) 14. Groups A, B, C, and D received 0%, 1%, 2%, and 4%, respectively, of total energy intake as arginine given in the form of crystalline arginine hydrochloride with 22%, 21%, 20%, and 18%, respectively, of total energy as whey protein. The average body weight after burn decreased equally in all groups. Resting metabolic expenditure on PBD 6 was higher in groups B (151% +/- 6% of preburn) and C (156% +/- 7%) than in groups A (131% +/- 4%) and D (136% +/- 3%). Ear-thickness response to dinitrofluorobenzene challenge on PBD 12 showed the best response in group C. The mortality rates of groups A, B, C, and D were 56%, 29%, 22%, and 56%, respectively. This study suggests that oral dietary arginine supplementation up to 2% of energy intake may be beneficial after burn injury.
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001120:Arginine / Q000097:blood / Q000627:therapeutic use*; D002056:Burns / Q000178:diet therapy* / Q000276:immunology / Q000378:metabolism; D002153:Calorimetry, Indirect; D004139:Dinitrofluorobenzene; D002149:Energy Intake; D004734:Energy Metabolism; D004750:Enteral Nutrition; D005260:Female; D006168:Guinea Pigs; D009752:Nutritional Status; D012882:Skin Tests
chemical_list: D001120:Arginine; D004139:Dinitrofluorobenzene