Revised structure of mycosubtilin, a peptidolipid antibiotic from Bacillus subtilis.
The structure of mycosubtilin, a peptidolipid antibiotic from Bacillus subtilis, was revised by FAB mass spectrometry, 2D NMR spectrometry and also by Edman degradation of the peptide resulting from the N-bromosuccinimide reaction. Four homologous beta-amino acid components were identified by capillary gas chromatography. The cyclopeptide mycosubtilin consists of seven alpha-amino acids in an LDDLLDL sequence closed by a beta-amino acid linkage similar to that found in other antibiotics of the iturin group.
D000900:Anti-Bacterial Agents; D001412:Bacillus subtilis; D055598:Chemical Phenomena; D002621:Chemistry; D008074:Lipoproteins; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011487:Protein Conformation
D000900:Anti-Bacterial Agents; D008074:Lipoproteins; C012448:mycosubtiline