Turnover of central biogenic amines in one-kidney, one-clip renal hypertensive rats.
Turnover rates, as estimated from the accumulation of the intermediates, 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) following decarboxylase inhibition, were used to investigate the relationship between central catecholaminergic and serotonergic neurons and the development of hypertension in the one-kidney, one-clip renal hypertensive rats. Results indicated that at one week following clipping, 5-HTP accumulation was decreased in the posterior hypothalamus. At 5 weeks no changes were observed. At 20 weeks higher accumulations of both DOPA and 5-HTP were observed in the medulla oblongata while in the anterior hypothalamus DOPA accumulation was increased.
D006916:5-Hydroxytryptophan / Q000032:analysis*; D000818:Animals; D001923:Brain Chemistry; D002395:Catecholamines / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004295:Dihydroxyphenylalanine / Q000032:analysis*; D006977:Hypertension, Renal / Q000378:metabolism*; D007031:Hypothalamus / Q000032:analysis; D008526:Medulla Oblongata / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism
D002395:Catecholamines; D012701:Serotonin; D004295:Dihydroxyphenylalanine; D006916:5-Hydroxytryptophan