The effect of diazepam on indices of 5-HT function in man.
The effects of acute and chronic diazepam administration on L-tryptophan induced prolactin release was studied in seven male volunteers. Acute diazepam diminished the prolactin neuroendocrine response to L-tryptophan. On chronic administration this effect was lost, suggesting tolerance had developed. The sedative effects of L-tryptophan were unaltered by either acute or chronic diazepam administration. A possible explanation for the tolerance development to the neuroendocrine effects may be the observed reduction in platelet 3H-imipramine binding that was observed.
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D003975:Diazepam / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D006993:Hypnotics and Sedatives; D007099:Imipramine / Q000097:blood; D008297:Male; D003708:Nordazepam / Q000097:blood; D011388:Prolactin / Q000097:blood; D012701:Serotonin / Q000502:physiology*; D013997:Time Factors; D014364:Tryptophan
D006993:Hypnotics and Sedatives; D012701:Serotonin; D003708:Nordazepam; D014364:Tryptophan; D011388:Prolactin; D007099:Imipramine; D003975:Diazepam