[Histo-immunolocalization of human and murine type I and III collagens in human cancers grafted to congenital athymic mice].
Seven human carcinomas and five sarcomas are microsurgically grafted to the nude mouse. We demonstrate with antibodies to human and murin Type I and III collagens that the capsule of the grafted human tumors and the intratumoral perivascular collagen are always of murin origin. Mouse Type I and III collagens take progressively the place of their human counterparts in the extracellular matrix of carcinoma. In contrast the intratumoral collagens of sarcomas are ever of human nature. The murin collagen, probably induced by the tumors, is perhaps one of the factors which prevents in the nude mouse the metastasis of the human grafted tumors.
D000818:Animals; D000906:Antibodies / Q000276:immunology; D000918:Antibody Specificity; D002277:Carcinoma / Q000032:analysis*; D003094:Collagen / Q000032:analysis* / Q000276:immunology; D006801:Humans; D007158:Immunologic Techniques; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D012516:Osteosarcoma / Q000032:analysis*; D014181:Transplantation Immunology
D000906:Antibodies; D003094:Collagen
Histo-immunolocalisation des collagènes de type I et III humains et murins de cancers humains greffés chez la souris athymique congénitale.