Evaluation of decoquinate, lasalocid, and monensin against experimentally induced sarcocystosis in calves.
Effects of decoquinate, lasalocid, and monensin against experimentally induced sarcocystosis (Sarcocystis bovicanis) were evaluated in 12 calves, 3 of which were inoculated, nontreated controls. Three additional calves were noninoculated, nontreated controls. Drugs were administered in the feed (33 mg/kg of feed) of the treated calves (3 calves/group) for 87 days. Eight of the 12 inoculated calves died from acute sarcocystosis during the experiment (the 3 inoculated, nontreated controls, the 3 calves given decoquinate, and 2 of the 3 calves given lasalocid). Large numbers of sarcocysts were found in tissues from inoculated calves that survived in the experiment (1 of the 3 calves given lasalocid and the 3 calves given monensin). Although large numbers of sarcocysts developed in the muscles of monensin-treated calves, monensin may have an ameliorating effect on acute sarcocystosis.
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D003667:Decoquinate / Q000627:therapeutic use*; D005663:Furans / Q000627:therapeutic use*; D006912:Hydroxyquinolines / Q000627:therapeutic use*; D007832:Lasalocid / Q000627:therapeutic use*; D008297:Male; D008985:Monensin / Q000627:therapeutic use*; D009928:Organ Specificity; D012522:Sarcocystis / Q000302:isolation & purification; D012523:Sarcocystosis / Q000188:drug therapy / Q000662:veterinary*
D005663:Furans; D006912:Hydroxyquinolines; D003667:Decoquinate; D008985:Monensin; D007832:Lasalocid