[Effect of vitamin A and hormones on the hormonal sensitivity of DMBA-induced mammary tumors in rats].
The treatment of rats with DMBA-induced mammary tumours with vitamin A and hormones in the cyclic regime increases the lifetime of animals, decreases both the tumour growth rate and increases the degree of their differentiation. The treatment with vitamin A alone and in combination with hormones lowers the level of estradiol and progesterone receptors in the rat mammary tumours. The high frequency of receptor-positive tumours and high level of estradiol and progesterone receptors in them were observed under the influence of hormones alone in the cyclic regime.
D000077713:17 alpha-Hydroxyprogesterone Caproate; D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004971:Estrus / Q000187:drug effects; D005260:Female; D006728:Hormones / Q000627:therapeutic use*; D006908:Hydroxyprogesterones / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000401:mortality; D011239:Prednisolone / Q000627:therapeutic use; D051381:Rats; D013739:Testosterone / Q000627:therapeutic use; D013997:Time Factors; D014801:Vitamin A / Q000627:therapeutic use*
D006728:Hormones; D006908:Hydroxyprogesterones; D007328:Insulin; D014801:Vitamin A; D000077713:17 alpha-Hydroxyprogesterone Caproate; D013739:Testosterone; D015127:9,10-Dimethyl-1,2-benzanthracene; D011239:Prednisolone
Vliianie vitamina A i gormonov na gormonochuvstvitel'nost' opukholeĭ molochnoĭ zhelezy, indutsirovannykh DMBA, u krys.