Inhibitory effect of liposome-encapsulated penicillin G on growth of Listeria monocytogenes in mouse macrophages.
Administration of penicillin G encapsulated in liposomes inhibited the proliferation of Listeria which infected mouse intraperitoneal resident macrophages whereas free penicillin G and/or liposomes did not. This result suggests that administration of antibiotics encapsulated in liposomes is an effective treatment for the intracellular infection.
D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D008081:Liposomes; D008089:Listeria monocytogenes / Q000187:drug effects* / Q000254:growth & development; D008264:Macrophages / Q000382:microbiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010400:Penicillin G / Q000494:pharmacology*
D008081:Liposomes; D010400:Penicillin G