Enzyme histochemistry of monoamine oxidase in the heart of aged rats.
The distribution of monoamine oxidase types A and B in the heart of young (3-month-old) and aged (26-month) Wistar rats was studied by histochemical methods. In young rats, MAO activity was higher in the left ventricle than in the right. Enzyme reactivity was present within both muscle cells and the blood vessel wall. Histochemical staining was abolished by clorgyline administration. In the heart of aged rats, we observed a very remarkable increase of clorgyline sensitive MAO activity primarily at the level of myocardial cells. The right ventricle showed the highest increase of MAO reactivity.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D003010:Clorgyline / Q000494:pharmacology; D006321:Heart / Q000254:growth & development*; D006651:Histocytochemistry; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D009206:Myocardium / Q000166:cytology / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012642:Selegiline / Q000494:pharmacology
D012642:Selegiline; D008995:Monoamine Oxidase; D003010:Clorgyline