title: HLA-DR antigen detection in giant cell lesions.
abstract: Sixty-six giant cell lesions ranging from inflammatory to neoplastic were evaluated for HLA-DR antigens using formalin/paraffin tissue and a monoclonal antibody labelled by the avidin-biotin peroxidase. HLA-DR antigens were expressed in nearly all lesions, predominantly on round, macrophage-like cells. Granulomatous inflammatory lesions were generally more immunoreactive than non-inflammatory lesions. Multinucleate giant cells were relatively unreactive in non-inflammatory lesions as compared to inflammatory lesions. Determination of HLA-DR expression does not appear to be helpful in discriminating between the various giant cell lesions.
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis*; D005870:Giant Cell Tumors / Q000276:immunology* / Q000473:pathology; D005882:Gingival Diseases / Q000276:immunology / Q000473:pathology; D006101:Granuloma, Giant Cell / Q000276:immunology* / Q000473:pathology; D006681:HLA-D Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007571:Jaw Diseases / Q000276:immunology / Q000473:pathology; D008264:Macrophages / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm; D006681:HLA-D Antigens; D006684:HLA-DR Antigens