title: Sequence similarities among the family of aminoacyl-tRNA synthetases.
abstract: Recent affinity labeling studies have led to the identification of lysine residues at the CCA binding site of tRNA in Escherichia coli methionyl- and tyrosyl-tRNA synthetases. The comparison of the labeled peptides to the known primary structures of the aminoacyl-tRNA synthetases reveals new sequence similarities among this family of enzymes. These similarities include a 'constant' lysine residue whose functional significance is discussed. Moreover, a systematic computer analysis was conducted to search for similarities between the aminoacyl-tRNA synthetases taken as pairs.
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000235:genetics*; D001483:Base Sequence; D055598:Chemical Phenomena; D002627:Chemistry, Physical
chemical_list: D000604:Amino Acyl-tRNA Synthetases