Aplysianin-A, an antibacterial and antineoplastic glycoprotein in the albumen gland of a sea hare, Aplysia kurodai.
Aplysianin-A, an antibacterial and antineoplastic factor in the albumen gland of the sea hare Aplysia kurodai, was isolated. It had a molecular weight of approximately 320 kD and consisted of subunits with a molecular weight of 85 kD. It contained 9.8% neutral sugar. Aplysianin A showed 50% inhibition of Bacillus subtilis growth at a concentration of 4 microgram protein/ml and 50% lysis of murine MM46 tumor cells at 14 ng protein/ml. A partial identity of antigenic specificity of the purified specimen with an antineoplastic factor from Aplysia eggs was observed in immunodiffusion tests.
D000418:Albumins; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D001048:Aplysia / Q000032:analysis*; D001412:Bacillus subtilis / Q000187:drug effects; D002460:Cell Line; D005088:Exocrine Glands / Q000032:analysis; D006023:Glycoproteins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D005779:Immunodiffusion; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy
D000418:Albumins; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D006023:Glycoproteins; C049060:aplysianin A