Evidence for proximal tubular cell origin of a sarcomatoid variant of human renal cell carcinoma.
A pure sarcomatoid variant of renal cell carcinoma obtained from a hydronephrotic kidney of an elderly white female was grown in tissue culture. Two parallel cell lines, one from the primary neoplasm and the other from a seeded metastasis within the same kidney have been cultured for more than 60 passages over a period of three years. Structural and functional studies of this neoplasm confirmed that it originated from proximal tubular cells.
D000818:Animals; D002292:Carcinoma, Renal Cell / Q000145:classification* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D002462:Cell Membrane / Q000502:physiology; D002478:Cells, Cultured; D004594:Electrophysiology; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000145:classification* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D007687:Kidney Tubules, Proximal / Q000166:cytology*; D051379:Mice; D008819:Mice, Nude; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D009368:Neoplasm Transplantation; D009392:Nephrectomy; D011991:Receptors, Virus / Q000032:analysis
D011991:Receptors, Virus