Nonocclusive chronic vascular catheterization of conscious unrestrained baboons.
A surgical technique is described for chronic arterial and venous catheterization of unrestrained adult baboons. Vascular access was achieved through a small (5 cm) abdominal incision and an extraperitoneal approach to the iliac vessels, which minimizes postoperative morbidity, discomfort, and restriction of movement. The method permits secure but nonocclusive catheterization, confirmed by angiography. Catheters were removed without further surgery, leaving the baboons intact for reuse. Catheters placed in the distal common or proximal external iliac vessels were all patent when removed at 46-61 days. The results demonstrate arterial pressure, pulse rates, drug administration, blood sampling, and plasma volume measurement as examples of the technique's application in conscious unrestrained baboons.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001800:Blood Specimen Collection; D002404:Catheterization / Q000379:methods*; D007083:Iliac Artery / Q000000981:diagnostic imaging; D007084:Iliac Vein / Q000000981:diagnostic imaging; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology; D010215:Papio; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology; D010953:Plasma Volume; D011674:Pulse / Q000187:drug effects; D011859:Radiography
D010656:Phenylephrine; D005996:Nitroglycerin