Effect of nitrogen on carbon dioxide elimination during continuous flow apneic ventilation in dogs.
Continuous endobronchial insufflation of air in paralyzed animals (continuous flow apneic ventilation - CFAV) has been shown to maintain adequate oxygenation and carbon dioxide removal. CFAV in patients using oxygen resulted in adequate oxygenation but a mean rise in PaCO2 of 0.6 mmHg/min (0.08 kPa/min). This experiment compared carbon dioxide removal in dogs with air and oxygen. Ten dogs were anesthetized and paralyzed, and CFAV was used for 1 h with either air or oxygen in a randomized fashion. Adequate oxygenation was obtained with air and oxygen. Normal PaCO2 levels were obtained with air; however, in the animals where oxygen was used, PaCO2 levels rose to a mean of 6.45 +/- s.e. mean 0.4 kPa (48.5 +/- s.e.mean 3.2 mmHg).
D000388:Air; D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D002245:Carbon Dioxide / Q000032:analysis / Q000502:physiology*; D004285:Dogs; D005260:Female; D008297:Male; D009584:Nitrogen / Q000494:pharmacology*; D010100:Oxygen / Q000502:physiology; D010313:Partial Pressure; D011650:Pulmonary Alveoli / Q000032:analysis; D011659:Pulmonary Gas Exchange; D012121:Respiration, Artificial / Q000379:methods*; D012143:Respiratory Physiological Phenomena
D002245:Carbon Dioxide; D009584:Nitrogen; D010100:Oxygen