A comparison of radiolabelled agents for thrombus imaging using a rabbit model.
The quantitative uptakes of five potential thrombus-localizing radiopharmaceuticals in experimental thrombi of the rabbit jugular vein have been compared to assist with the selection of a thrombus imaging agent for clinical use. Three hours after injection, 111In-platelets were clearly the agent of choice but at 18 h 99mTc-fibrinogen had more favourable characteristics. Both agents were superior to 99mTc-plasmin or its acyl derivatives, including 99mTc-streptokinase-activated anisoylplasminogen. The ease of preparation coupled with favourable biological properties suggest that 99mTc-fibrinogen should be of value in the clinical situation.
D000818:Animals; D007204:Indium; D007457:Iodine Radioisotopes; D007601:Jugular Veins / Q000000981:diagnostic imaging*; D009942:Organometallic Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives; D011817:Rabbits; D011877:Radionuclide Imaging; D013667:Technetium; D013927:Thrombosis / Q000000981:diagnostic imaging*
D007457:Iodine Radioisotopes; D009942:Organometallic Compounds; D007204:Indium; C032950:indium oxine; D015125:Oxyquinoline; D013667:Technetium