[Characterization of a factor produced by human alloreactive T lymphocyte clones, active on the eosinophils and precursors of erythroid strains].
Alloreactive T-cell clones obtained from cells infiltrating a human rejected kidney graft were shown to produce upon specific antigenic stimulation with interleukin 2, a factor triggering the proliferation of an interleukin 3 dependent murine cell line. The lymphokine responsible for this activity was a monomeric glycoprotein (MW = 41,000) exhibiting on one hand chemotactic as well as activating properties on murine and human eosinophils respectively, and on the other hand a burst promoting activity. Its biochemical and biological features strongly suggest that this factor cannot be likened to any known human lymphokine.
D000818:Animals; D002631:Chemotactic Factors, Eosinophil / Q000302:isolation & purification; D007377:Interleukin-3 / Q000302:isolation & purification*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008970:Molecular Weight; D013601:T-Lymphocytes / Q000378:metabolism*
D002631:Chemotactic Factors, Eosinophil; D007377:Interleukin-3
Caractérisation d'un facteur produit par des clones lymphocytaires T alloréactifs humains, actif sur les éosinophiles et sur les précurseurs de la lignée érythroïde.