In vitro activity of ofloxacin against 210 clinical isolates of typhoid salmonellae.
210 clinical isolates of typhoid salmonellae, cultivated from blood of patients with typhoid fever (108 strains of Salmonella typhi, 99 strains of Salmonella paratyphi A and three strains of Salmonella paratyphi B) as well as 266 random clinical isolates of Escherichia coli (n = 152), Klebsiella spp. (n = 51) and Proteus spp. (n = 63) were tested for susceptibility to ofloxacin, using an agar dilution method. All the typhoid salmonellae were found to be highly sensitive to ofloxacin with MICs ranging from 0.03 mg/l to 0.12 mg/l. The sensitivity pattern of enterobacteriaceae was comparable to data published internationally.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology*; D010284:Paratyphoid Fever / Q000382:microbiology; D012475:Salmonella / Q000187:drug effects*; D012482:Salmonella paratyphi A / Q000187:drug effects* / Q000302:isolation & purification; D012484:Salmonella paratyphi B / Q000187:drug effects* / Q000302:isolation & purification; D012485:Salmonella typhi / Q000187:drug effects* / Q000302:isolation & purification; D014435:Typhoid Fever / Q000382:microbiology
D000900:Anti-Bacterial Agents; D010078:Oxazines; D015242:Ofloxacin