title: Fish oil in angina pectoris.
abstract: The effect of 12 weeks supplementation with fish oil on the number of anginal attacks and consumption of glyceryltrinitrate in 36 patients with stable angina pectoris was evaluated in a clinically controlled trial using a vegetable oil as placebo. Fish oil caused a decrease in frequency of angina, but was not significantly superior to placebo. However, due to the small sample size and a high spontaneous variation in number of anginal attacks, a risk of up to 50% of overlooking a 30% reduction in anginal attacks could be estimated. A significant inhibition of the epinephrine-induced platelet aggregation and a significant increase in intraplatelet cyclic AMP were induced by fish oil.
mesh_terms: D000787:Angina Pectoris / Q000188:drug therapy*; D001792:Blood Platelets / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D005395:Fish Oils / Q000627:therapeutic use*; D006801:Humans; D005996:Nitroglycerin / Q000627:therapeutic use; D010979:Platelet Function Tests
chemical_list: D005395:Fish Oils; D005996:Nitroglycerin