Interleukin 1 and interleukin 2 production in the acquired immune deficiency syndrome (AIDS) and AIDS-related complex.
Interleukin 1 (IL-1) production by freshly isolated and lipopolysaccharide (LPS)-stimulated adherent monocytes-macrophages and IL-2 production by unstimulated and phytohemagglutinin (PHA)-activated T cells were examined in patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC). Spontaneous IL-1 production was significantly increased in patients with ARC, whereas IL-1 production by LPS-activated monocytes-macrophages was significantly decreased in patients with AIDS. Spontaneous IL-2 production by unstimulated T cells was significantly decreased in AIDS and IL-2 produced by PHA-activated T cells was significantly decreased in AIDS and ARC. This study shows abnormality of both monocyte and T-cell functions in AIDS and ARC. These abnormalities appear to play a role in the immunopathogenesis of AIDS.
D000386:AIDS-Related Complex / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000032:analysis; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000145:classification / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D007375:Interleukin-1; D007376:Interleukin-2