[Mitomycin C-induced mutagenesis].
The mutagenic effect of mitomycin C (MC) has been shown in the S phase of Crepic capillaris cells. The repair ability of MC-induced DNA lesions proves exceedingly high, due to post-replicative and excision repair processes. In the experiments with MC-pretreatment of Crepic capillaris cells, nonmutagenic concentration of 1 microgram/ml provides inducible repair system--"adaptive response", which considerably decreases the levels of mutagenesis induced by MC at concentrations of 10, 20 and 40 micrograms/ml. Under adaptive response, the action of methyltransferase is possible.
D002869:Chromosome Aberrations / Q000187:drug effects*; D004260:DNA Repair; D016685:Mitomycin; D008937:Mitomycins / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens; D010944:Plants / Q000235:genetics
D008937:Mitomycins; D009153:Mutagens; D016685:Mitomycin
Mutagenez, indutsirovannyĭ mitomitsinom C.