Strategies for preventing aspirin-induced gastric bleeding.
Prostaglandins protect the gastric mucosa in animals, but the evidence of an effect independent of pH changes in man is not overwhelming. Gastrointestinal bleeding because of non-steroidal anti-inflammatory drugs is a major clinical problem, which we have investigated in a model system measuring bleeding rates caused by short-term administration of aspirin. Of the various strategies tested, only those that elevated intra-gastric pH reduced aspirin-induced bleeding.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives; D002417:Cattle; D016620:Enprostil; D005228:Fatty Acids, Essential; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000627:therapeutic use; D008239:Lysine / Q000008:administration & dosage / Q000031:analogs & derivatives; D008297:Male; D008892:Milk; D031665:Oenothera biennis; D010938:Plant Oils; D011459:Prostaglandins E, Synthetic / Q000627:therapeutic use; D011899:Ranitidine / Q000627:therapeutic use; D017965:gamma-Linolenic Acid
D000893:Anti-Inflammatory Agents; D005228:Fatty Acids, Essential; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D010938:Plant Oils; D011459:Prostaglandins E, Synthetic; C028498:evening primrose oil; D017965:gamma-Linolenic Acid; D011899:Ranitidine; D019787:Linoleic Acid; D016620:Enprostil; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate