Facilitation of stimulatory effect of chlordiazepoxide-amphetamine combination by subacute administration of chlordiazepoxide in mice.
Spontaneous locomotor activity was tested in CD-1 mice receiving subacutely (for 4 days) chlordiazepoxide (10 mg/kg) and then treated with d-amphetamine (0.5 or 1 mg/kg) and various doses of chlordiazepoxide (2.5, 5 or 10 mg/kg) separately or in combination. Chlordiazepoxide pretreatment enhanced the stimulatory effect of the chlordiazepoxide-amphetamine combination.
D000818:Animals; D002707:Chlordiazepoxide / Q000008:administration & dosage*; D003913:Dextroamphetamine / Q000008:administration & dosage*; D004357:Drug Synergism; D004361:Drug Tolerance; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D013268:Stimulation, Chemical; D013997:Time Factors
D002707:Chlordiazepoxide; D003913:Dextroamphetamine