title: Adrenal medulla grafts produce blood-brain barrier dysfunction.
abstract: The results of this study show that grafts of adrenal medulla into the rat brain parenchyma or ventricle produced significant blood-brain barrier dysfunction. Systemically administered protein rapidly entered either the grafts, the surrounding brain tissue or the cerebrospinal fluid. The grafted chromaffin cells avidly took up blood-borne radiolabelled amine. Thus, autonomic tissue transplants prevented normal reconstruction of the blood-brain barrier after surgery and indefinitely exposed host brain tissue to blood-borne compounds.
mesh_terms: D000313:Adrenal Medulla / Q000098:blood supply / Q000378:metabolism / Q000502:physiology / Q000637:transplantation*; D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000098:blood supply* / Q000378:metabolism; D002540:Cerebral Cortex / Q000098:blood supply / Q000378:metabolism; D002552:Cerebral Ventricles / Q000098:blood supply / Q000378:metabolism; D004298:Dopamine; D006624:Hippocampus / Q000098:blood supply / Q000378:metabolism; D006735:Horseradish Peroxidase; D007142:Immunoglobulin gamma-Chains; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D007142:Immunoglobulin gamma-Chains; D011506:Proteins; D006735:Horseradish Peroxidase; D004298:Dopamine