Neural circuits involved in parkinsonian motor disturbance studied in monkeys.
The outline of neurophysiological studies on a parkinsonian model in monkeys with mesencephalic ventromedial tegmental lesions was presented. By radiologically and physiologically controlled, selective deep-seated lesions, rigidity with or without tremor could be produced separately. From the results obtained mainly by microrecording from various levels of the brain, a neural circuit involved in production of rigidity and tremor has been proposed.
D000818:Animals; D002490:Central Nervous System / Q000503:physiopathology*; D004195:Disease Models, Animal; D000882:Haplorhini; D010302:Parkinson Disease, Secondary / Q000503:physiopathology*