Cortical hyperostosis and enthesopathy due to long-term etretinate administration.
Two cases are presented which show a severe ossification disorder that we observed during long-term administration of a synthetic vitamin A analogue (etretinate). The radiologic findings are discussed in relation to the skeletal abnormalities, which occur in chronic vitamin A intoxication and retinoid hyperostosis, which has been recently described in the literature as a side effect of another retinoid (isotretinoin).
D000328:Adult; D005050:Etretinate / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000139:chemically induced*; D010009:Osteochondrodysplasias / Q000139:chemically induced*; D013997:Time Factors
D005050:Etretinate