TRH and LH-RH distribution in discrete nuclei of the human hypothalamus: evidence for a left prominence of TRH.
Thyrotropin-releasing hormone (TRH) and luteinizing hormone-releasing hormone (LH-RH) have been measured by radioimmunoassay in individual human hypothalamic nuclei. A significant lateralization has been found for TRH in the ventromedial, dorsal and paraventricular nuclei, with higher concentration in the left side. In contrast LH-RH values did not differ between the left and the right side. This finding represents an additional example of cerebral specialization and the first report of lateralized peptide distribution in the human hypothalamus.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis*; D006801:Humans; D007031:Hypothalamus / Q000032:analysis* / Q000473:pathology; D008875:Middle Aged; D013973:Thyrotropin-Releasing Hormone / Q000032:analysis*; D014018:Tissue Distribution
D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone