Reduced anti-immobility effect of repeated desipramine (DMI) treatment in adult rats undernourished at perinatal age.
Adult rats submitted to a protein deprivation schedule at perinatal age showed a reduced anti-immobility effect following seven days of DMI treatment (20 mg/kg/day) in the forced swimming test. The ineffectiveness of DMI treatment is attributed to the inability of deprived animals to produce neuronal adaptative changes in central monoaminergic pathways.
D000818:Animals; D003863:Depression / Q000503:physiopathology*; D003891:Desipramine / Q000494:pharmacology*; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011247:Pregnancy; D011502:Protein-Energy Malnutrition / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming
D003891:Desipramine