DNA damage and repair in mouse liver.
The formation of DNA adducts in mouse liver has been demonstrated for numerous chemicals including members of most major classes of carcinogens. Considerably less is known about the persistence and repair of DNA adducts in mouse liver. Likewise, major gaps in present knowledge exist regarding the molecular dosimetry of DNA adducts and their potential for miscoding during continuous exposure to high versus low doses of carcinogens. A prime example of this is 2-acetylaminofluorene (2-AAF), the carcinogen used in the ED01 megamouse study. There are no molecular dosimetry studies on the DNA adducts of 2-AAF, even though such a unique data base exists for the dose-response relationship of mouse liver tumors. Reviewing the pertinent literature, identifying deficiencies, and conducting the required research will hopefully permit a better determination of the relevance of mouse liver tumors to man.
D015073:2-Acetylaminofluorene / Q000494:pharmacology; D016604:Aflatoxin B1; D000348:Aflatoxins / Q000494:pharmacology; D000477:Alkylating Agents / Q000494:pharmacology; D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology; D002273:Carcinogens / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D004260:DNA Repair; D008099:Liver / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D051379:Mice; D011083:Polycyclic Compounds / Q000494:pharmacology; D010128:p-Aminoazobenzene / Q000494:pharmacology
D000348:Aflatoxins; D000477:Alkylating Agents; D001555:Benzene Derivatives; D002273:Carcinogens; D011083:Polycyclic Compounds; D010128:p-Aminoazobenzene; D004247:DNA; D015073:2-Acetylaminofluorene; D016604:Aflatoxin B1