Hematological aspect of Rh deficiency syndrome: a case report and a review of the literature.
The hematological aspects of the original case of Rhmod are reported. The subject, as in other reported cases, had a chronic hemolytic anemia characterized by stomatocytosis, reduced osmotic fragility, and abnormal autohemolysis correctable with the addition of glucose. The 51Cr red cell survival studies showed the spleen to be the preferential site of red cell destruction and splenectomy produced a dramatic improvement in red cell survival. The topic of Rh deficiency syndrome (Rhnull and Rhmod) is briefly reviewed with regard to the number of cases reported, to genetic aspects, to the hematological findings, and to the results of splenectomy.
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood; D002860:Chromium Radioisotopes; D004905:Erythrocyte Aging; D005260:Female; D006801:Humans; D007519:Isoantigens / Q000172:deficiency* / Q000235:genetics; D008297:Male; D010641:Phenotype; D012204:Rh-Hr Blood-Group System / Q000235:genetics / Q000276:immunology*
D002860:Chromium Radioisotopes; D007519:Isoantigens; D012204:Rh-Hr Blood-Group System