Recurrent meningococcal meningitis associated with deficiencies of C8 and anti-meningococcal antibody.
A patient with fatal recurrent meningococcal meningitis is described. Detailed complement and immunological investigation revealed a combined deficiency of C8 and anti-meningococcal antibody. An inability to make anti-meningococcal antibody in C8 deficient patients has not been previously reported.
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D003185:Complement C8 / Q000172:deficiency*; D006801:Humans; D008297:Male; D008585:Meningitis, Meningococcal / Q000276:immunology*; D009345:Neisseria meningitidis / Q000276:immunology*; D012008:Recurrence
D000907:Antibodies, Bacterial; D003185:Complement C8