Galactose ingestion increases vascular permeability and collagen solubility in normal male rats.
In view of the similarity of cataracts and neuropathy in galactose-fed and diabetic rats, the present experiments were undertaken to determine whether consumption of galactose-enriched diets (10, 25, or 50% by weight) also increases collagen crosslinking and permeation of vessels by 125I-albumin analogous to that observed in diabetic rats. The observations in these experiments: demonstrate that consumption of galactose-enriched diets for 3 wk selectively increases 125I-albumin permeation of the same vascular beds affected in diabetic rats and by diabetic vascular disease in humans (i.e., the aorta and vessels in the eye, kidney, sciatic nerve, and new tissue formed in the diabetic milieu); demonstrate that the susceptibility of the vasculature to aldose reductase-linked injury (increased permeability) varies greatly in different tissues; indicate that collagen solubility (crosslinking) changes in galactose-fed rats differ sharply from those in diabetic rats; and provide new evidence that consumption of galactose-enriched diets induces a hypogonadal state in male rats.
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects*; D003094:Collagen / Q000378:metabolism*; D005690:Galactose / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology; D048289:Imidazolidines; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000033:anatomy & histology; D051381:Rats; D011919:Rats, Inbred Strains; D012710:Serum Albumin, Bovine / Q000378:metabolism; D012995:Solubility; D013739:Testosterone / Q000097:blood; D014018:Tissue Distribution
D007093:Imidazoles; D048289:Imidazolidines; D009281:Naphthalenes; C040550:tolrestat; D012710:Serum Albumin, Bovine; D013739:Testosterone; D003094:Collagen; D000449:Aldehyde Reductase; C026411:sorbinil; D005690:Galactose