[Passive transport of Ca2+ in a myometrium mitochondria fraction].
Na+, pH, prostaglandin F2 alpha are studied for their effect on Ca2+ transport into fractions of cow's myometrium mitochondria. Na+ does not affect a passive release of Ca2+ from mitochondria and its energy-dependent accumulation. A decrease of the incubation medium pH from 7.5 to 6.5 stimulates Ca2+ release from mitochondria and inhibits its energy-dependent pumping into them. Prostaglandin F2 alpha (10(-8)--2 X 10(-4) M) does not affect the activity of Ca2+ accumulation and release systems. A conclusion is made that the Na+-Ca2+-exchange system is absent in mitochondria of smooth muscle cells and Ca2+ release proceeds as a result of H+-Ca2+-antiport system functioning.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D002417:Cattle; D015237:Dinoprost; D004734:Energy Metabolism; D005260:Female; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007700:Kinetics; D008928:Mitochondria / Q000378:metabolism*; D009215:Myometrium / Q000378:metabolism*; D011460:Prostaglandins F / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology
D011460:Prostaglandins F; D000001:Calcimycin; D012964:Sodium; D015237:Dinoprost; D002118:Calcium
Passivnyĭ transport Ca2+ vo fraktsii mitokhondriĭ miometriia.