[Synthesis of (8Z,11Z,14Z)-eicosatrien-5-ynoic (5,6-dehydroarachidonic) acid and its transformation into [5,6-3H]arachidonic acid and [5,6-3H]prostaglandins E2 and F2 alpha].
8Z,11Z,14Z-Eicosatriene-5-ynoic acid and its tritium-labelled analogue, [5,6-3H]arachidonic acid, have been synthesized on the basis of acetylenic compounds. [5,6-3H]Arachidonic acid has been used as substrate for the enzymatic synthesis of [5,6-3H]PGE2 and [5,6-3H]PGF2 alpha.
D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000378:metabolism; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D015237:Dinoprost; D015232:Dinoprostone; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis*; D011458:Prostaglandins E / Q000096:biosynthesis / Q000378:metabolism*; D011460:Prostaglandins F / Q000096:biosynthesis / Q000378:metabolism*
D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D011458:Prostaglandins E; D011460:Prostaglandins F; D016718:Arachidonic Acid; C025421:eicosa-8,11,14-trien-5-ynoic acid; D015237:Dinoprost; D015126:8,11,14-Eicosatrienoic Acid; D015232:Dinoprostone
Sintez (8Z,11Z,14Z)-éĭkozatrien-5-inovoĭ (5,6-degidroarakhidonovoĭkisloty i ee prevrashchenie v [5,6-3H]arakhidonovuiu kislotu, [5,6-3H]prostaglandiny E2 i F2 alpha.