The allograft response.
The allograft response is a response by host T lymphocytes reacting to transplantation antigens that are carried on allogeneic lymphoreticuler cells. In vivo this response usually leads to graft rejection. It is possible to circumvent this response by the elimination of the lymphoreticular cells from the grafts prior to transplantation. The paradox of the strong response to transplantation antigen on lymphoreticular cells and the weak response to the same antigen on graft parenchymal cells can be explained by the signaling requirements for T lymphocyte activation.
D000818:Animals; D003524:Cyclosporins / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000628:therapy; D006084:Graft Rejection; D006649:Histocompatibility Antigens / Q000032:analysis; D006801:Humans; D007107:Immune System; D016381:Islets of Langerhans Transplantation; D008285:Major Histocompatibility Complex; D008433:Mathematics; D009924:Organ Culture Techniques; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
D003524:Cyclosporins; D006649:Histocompatibility Antigens