Dibromochloropropane (DBCP): an 8-year reevaluation of testicular function and reproductive performance.
The current study summarizes an 8-year reassessment of testicular function and reproductive performance in 15 workers with dibromochloropropane (DBCP)-induced azoospermia and oligozoospermia. Recovery of spermatogenesis was observed in four oligozoospermic and three azoospermic men whose plasma follicle-stimulating hormone (FSH) concentration was normal during the whole period. A marked increase in FSH and luteinizing hormone concentrations above the upper limit of normal was found in the azoospermic workers who did not recover. No significant changes in FSH concentrations were detected in both recovered and nonrecovered oligozoospermic men. Testosterone levels of all patients were normal at all times. Paternal exposure to DBCP was not associated with increased risk of fetal malformations or spontaneous abortion.
D002617:Chemical Industry; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007557:Israel; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009784:Occupational Diseases / Q000097:blood / Q000139:chemically induced; D009845:Oligospermia / Q000097:blood / Q000139:chemically induced; D011247:Pregnancy; D011407:Propane / Q000009:adverse effects / Q000031:analogs & derivatives*; D012098:Reproduction / Q000187:drug effects*; D013076:Sperm Count / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects*; D013997:Time Factors
D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; C007318:1,2-dibromo-3-chloropropane; D011407:Propane