[Study on the concentration of FT-207 and 5-FU in serum and tissues of bladder tumor and prostatic carcinoma].
Serum and tissue concentrations of 5-FU and FT-207 were estimated in 26 patients with bladder tumor or prostatic carcinoma after administration of FT-207 suppositories. The 5-FU concentration in bladder tumor was higher than in normal mucosal bladder tissue. The 5-FU concentration of prostatic cancer was almost equal to that of normal prostatic tissue. Relatively higher concentrations of 5-FU were recognized in bladder tumor of a high stage than of a low stage. There were no differences of serum and tissue 5-FU concentration in bladder tumor between patients more than 65 years old and those under 65 years old. No side-effects occurred in any case during suppository administration.
D000328:Adult; D000368:Aged; D005472:Fluorouracil / Q000032:analysis* / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000032:analysis; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D013488:Suppositories; D005641:Tegafur / Q000032:analysis* / Q000097:blood; D001743:Urinary Bladder / Q000032:analysis; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000473:pathology
D013488:Suppositories; D005641:Tegafur; D005472:Fluorouracil