[Dose-related effect of dexamethasone on the poly-(ADP ribose) synthesis of human lymphocytes].
Poly (ADP-ribose) synthesis and DNA synthesis after medication of dexamethasone was determined in 16 cases. Poly (ADP-ribose) synthesis in peripheral lymphocytes decreased after low dose dexamethasone. In a second trial with double doses of dexamethasone no significant decrease of Poly (ADP-ribose) in relation to DNA synthesis could be shown. There seems to be a connection between suppression of Poly (ADP-ribose) and cell cyclus of lymphocytes, specially the S-phasis of lymphocytes. The decrease of Poly (ADP-ribose) synthesis after cortisone medication is dosis connected. Dosis, interval of dosis and over all dosis are closely related to the effect of immunosuppression of this steroidal hormone.
D000368:Aged; D004260:DNA Repair / Q000187:drug effects; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009702:Nucleoside Diphosphate Sugars / Q000096:biosynthesis*; D011064:Poly Adenosine Diphosphate Ribose / Q000096:biosynthesis*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors
D009702:Nucleoside Diphosphate Sugars; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011064:Poly Adenosine Diphosphate Ribose; D003907:Dexamethasone
Dosisabhängiger Einfluss von Dexamethason auf die Poly-(ADP-Ribose-)Synthese menschlicher Lymphozyten.