Rearrangement of the c-myc gene in two giant cell carcinomas of the lung.
The c-myc oncogene was found to be rearranged in a human cell line of giant cell carcinoma of the lung (C-Lu65) and in a human primary giant cell carcinoma of the lung (LuC38C). The rearrangements in C-Lu65 and LuC38C were in regions about 7.5 kb and 6 kb, respectively, upstream from the transcription initiation site. No rearrangement of the c-myc gene was observed in a non-cancerous portion (LuC38N) of the lung of the patient who carried LuC38C. These results suggest that rearrangement of the c-myc gene may play some role in tumorigenesis of giant cell carcinoma of the lung.
D002277:Carcinoma / Q000235:genetics*; D002460:Cell Line; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D011519:Proto-Oncogenes; D014178:Translocation, Genetic