Stimulation of the mouse monocytes by Listeria monocytogenes.
The bacteria of Wellshimer's strain L. monocytogenes and their extract (LMA) showed in vitro the mitogenic activity which was demonstrated by increased proliferation of normal bone marrow cells and blood monocytes of the mouse strains resistant (C57Bl/6) and susceptible (DBA/2) to listeriosis. In the same experimental conditions the proliferation of spleen macrophages and resident peritoneal macrophages was not influenced. Besides, C57Bl/6 bone marrow cells, activated by live or killed L. monocytogenes, produced some growth factor for secondary bone marrow cell cultures.
D000818:Animals; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D008089:Listeria monocytogenes / Q000502:physiology; D008088:Listeriosis / Q000097:blood / Q000503:physiopathology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008262:Macrophage Activation; D008264:Macrophages / Q000166:cytology; D051379:Mice; D008815:Mice, Inbred Strains; D008934:Mitogens / Q000378:metabolism; D009000:Monocytes / Q000166:cytology / Q000276:immunology* / Q000382:microbiology; D013154:Spleen / Q000166:cytology
D008934:Mitogens