[Ultrastructural study of rat mammary tumors and human breast cancer cells following treatment with tamoxifen].
In order to predict the efficacy of hormonal therapy for breast cancer patients, early ultrastructural changes of rat mammary tumors and human breast cancer cells have been studied following treatment with tamoxifen. Following the treatment, complex nuclear bodies (CNB) were increased, and ring-shaped nucleoli were observed in both the rat mammary tumors and the human breast cancer cells. In the tamoxifen-treated human beast cancer patients, CNB increased, as estrogen receptor concentration rose. Shrunken nucleli and intranuclear rodlet were observed only in the tamoxifen-treated human cancer patients.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000328:Adult; D000368:Aged; D000818:Animals; D001943:Breast Neoplasms / Q000032:analysis / Q000188:drug therapy / Q000648:ultrastructure*; D002466:Cell Nucleolus / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D013629:Tamoxifen / Q000627:therapeutic use*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D013629:Tamoxifen; D015127:9,10-Dimethyl-1,2-benzanthracene