Synthesis and vascular actions of an arachidonic acid ethylene-diamino-triethyl-ester (AA-EDTA) derivative.
An ethylene-diamino-triethyl-ester derivative of arachidonic acid (AA-EDTA) was newly synthesized and tested for its coronary vasoactivity in isolated perfused cat coronary arteries. This arachidonic acid analog exerted a coronary vasodilator effect and significantly antagonized the coronary vasoconstrictor effect of LTD4. The constrictor response to the thromboxane analog carbocyclic thromboxane A2 was unaffected by AA-EDTA. These properties of AA-EDTA may be useful in counteracting the vasoconstrictor influence of leukotrienes in situations such as coronary artery vasospasm.
D000818:Animals; D001095:Arachidonic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D002415:Cats; D003331:Coronary Vessels / Q000187:drug effects*; D004347:Drug Interactions; D004492:Edetic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008297:Male; D013189:SRS-A / Q000037:antagonists & inhibitors / Q000494:pharmacology; D013928:Thromboxane A2 / Q000031:analogs & derivatives / Q000494:pharmacology
D001095:Arachidonic Acids; D013189:SRS-A; C024587:thromboxane A2, carbocyclic; C050195:arachidonic acid-EDTA; D013928:Thromboxane A2; D004492:Edetic Acid