Further studies on the effects of a thyrotropin releasing hormone analogue on locomotor activity in the rat.
In these experiments, the relationship between two of the variables of locomotion, stepping frequency and velocity, after injection of the TRH analogue RX77368 (10 mg/Kg i.p.), has been studied. A shift towards higher stepping frequencies was observed, confirming previous observations. However, there was no difference between the velocities of locomotion produced by treated and control rats. In the treated rats the relationship between stepping frequency and velocity was disturbed, such that a higher stepping frequency was employed to attain any particular velocity. This was accompanied by a reduction in stride length. Possible reasons for this disturbance are discussed in terms of changes in muscle stiffness and proprioceptive reflexes.
D000818:Animals; D001696:Biomechanical Phenomena; D005260:Female; D007700:Kinetics; D009043:Motor Activity / Q000187:drug effects*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology
D013973:Thyrotropin-Releasing Hormone; C027979:L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide; D011761:Pyrrolidonecarboxylic Acid