Guanine nucleotide regulatory proteins as transducers of receptor-stimulated neutrophil activation.
There exists a family of homologous GTP-binding regulatory proteins (the G proteins) which couple receptors to cellular effector systems. Several lines of evidence indicate a major role for a G protein in mediating neutrophil activation by a variety of chemotactic factors. We here describe studies on guanine nucleotide regulation of formyl peptide receptor affinity in a permeabilized neutrophil preparation. The characterization of neutrophil G protein with anti-G protein antibodies is also discussed.
D019204:GTP-Binding Proteins / Q000032:analysis / Q000502:physiology*; D006150:Guanine Nucleotides / Q000494:pharmacology; D016244:Guanosine 5'-O-(3-Thiotriphosphate); D006160:Guanosine Triphosphate / Q000031:analogs & derivatives / Q000494:pharmacology; D007118:Immunoassay; D008274:Magnesium / Q000494:pharmacology; D008954:Models, Biological; D009504:Neutrophils / Q000276:immunology*; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic / Q000378:metabolism*; D012964:Sodium / Q000494:pharmacology; D013873:Thionucleotides / Q000494:pharmacology
D006150:Guanine Nucleotides; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic; D013873:Thionucleotides; D016244:Guanosine 5'-O-(3-Thiotriphosphate); D006160:Guanosine Triphosphate; D012964:Sodium; D019204:GTP-Binding Proteins; D008274:Magnesium