[Immunocytochemical demonstrating of a neurofibrillary component of the peripheral nervous system manifested by a human natural antibody].
Human serum SH2172, obtained from a girl suffering from bullous dermatosis, showed a natural immunoreactivity against the peripheral nervous system (PNS) of rat, mouse and hamster. Immunocytochemical staining and examination by light and electron microscopy demonstrated an intracellular neurofibrillary network localized in neurites and neuronal pericaryons. Comparative testing clearly showed that SH2172 immunoreactivity is different from that of the antibodies against the triplet of proteins NFP70, 160 and 200 kD. This unique serum should be a useful probe to study PNS neurocytoskeleton.
D000293:Adolescent; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007113:Immunity, Innate; D007124:Immunoenzyme Techniques; D009454:Neurofibrils / Q000032:analysis* / Q000276:immunology; D010525:Peripheral Nerves / Q000032:analysis / Q000276:immunology* / Q000473:pathology; D051381:Rats; D013564:Sympathetic Nervous System / Q000473:pathology
D000906:Antibodies
Mise en évidence immunocytochimique d'un composant neurofibrillaire du système nerveux périphérique révélé par un anticorps naturel humain.