title: Disruption of positional fields in apterous imaginal discs of Drosophila.
abstract: Certain combinations of alleles at the apterous locus generate wings with extra copies of wing margin structures, some of which are located far from the normal margin. We have examined wing imaginal discs from these mutants, using position-specific antibodies as probes for two-dimensional patterning in the discs. Our results indicate that the adult phenotypes arise from unprecedented disruptions in the two-dimensional pattern of the disc epithelia. Examination of other apterous mutants suggest that pattern alterations may be a general consequence of lesions at this locus.
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D002470:Cell Survival; D004331:Drosophila melanogaster / Q000196:embryology*; D005455:Fluorescent Antibody Technique; D009024:Morphogenesis; D009154:Mutation; D010641:Phenotype; D014921:Wings, Animal / Q000196:embryology*
chemical_list: D000911:Antibodies, Monoclonal