Immunoglobulin-producing cells in labial salivary glands of patients with rheumatoid arthritis and systemic lupus erythematosus.
The distribution of immunoglobulin-producing cells within labial salivary glands from normal individuals (n = 7) and patients with rheumatoid arthritis (n = 10) and systemic lupus erythematosus (n = 9) was studied using morphometric and indirect immunoperoxidase methods. Cell counts revealed a significant increase in the density of IgG cells within glands from both patient groups compared with glands from normal individuals. No significant differences in the density of IgA- or IgM-producing cells between the 3 groups were observed although large individual variations were apparent. Histomorphometric studies showed an increase in the lymphoid compartment and a decrease in glandular elements within glands from the 2 patient groups. When data for all specimens were pooled a significant positive correlation was obtained between the percent area of stromal lymphoid tissue and density of IgG and IgM cells.
D000328:Adult; D000921:Antibody-Producing Cells / Q000473:pathology*; D001172:Arthritis, Rheumatoid / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008046:Lip / Q000473:pathology*; D008180:Lupus Erythematosus, Systemic / Q000473:pathology*; D008875:Middle Aged; D012469:Salivary Glands / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000473:pathology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M