title: Carbon dioxide laser use in wound sealing and epikeratophakia.
abstract: This paper presents current clinical and experimental uses of the carbon dioxide laser and the results of our human and animal tissue fusion investigations. Trials were conducted with human scleral and corneal eye bank tissue and in albino rabbits. With power settings of 100 to 200 mW, optimal laser effect consisting of slight whitening and minimal edge shrinkage occurred between 10 and 70 mJ of total energy. No tissue adherence could be demonstrated with the parameters tested. A final study was made on the feasibility of sealing an epikeratophakia lenticle to its recipient bed using the carbon dioxide laser. The average force required to remove the button in the control experiments was 6.45 g and this increased to 6.99 g after laser treatment although no fusion was apparent. This was statistically significant (P less than .05).
mesh_terms: D000268:Adhesiveness; D000818:Animals; D002245:Carbon Dioxide; D003315:Cornea / Q000601:surgery*; D016039:Corneal Transplantation; D006801:Humans; D053685:Laser Therapy / Q000379:methods; D011817:Rabbits; D012590:Sclera / Q000601:surgery*
chemical_list: D002245:Carbon Dioxide