Effect of enprostil, a synthetic prostaglandin E2 on 24 hour intragastric acidity, nocturnal acid and pepsin secretion.
We have studied the effect of a prostaglandin E2 analogue (enprostil), on intragastric acidity, gastric acid and pepsin outputs during a 24 hour period in nine patients with duodenal ulcer in remission. Enprostil 35 micrograms bd dose inhibited 24 hour intragastric acidity by 38% and a 70 micrograms nocturnal dose by 33%. Decrease in nocturnal pepsin secretion was both volume and concentration related.
D000328:Adult; D002940:Circadian Rhythm; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000378:metabolism; D016620:Enprostil; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010434:Pepsin A / Q000378:metabolism*; D011459:Prostaglandins E, Synthetic / Q000378:metabolism / Q000627:therapeutic use*
D011459:Prostaglandins E, Synthetic; D010434:Pepsin A; D016620:Enprostil