Impact of virus infection on host cell protein synthesis.
There is good evidence that a variety of viruses encode functions that inhibit activation of either ribonuclease L or the Pl/eIF-2 alpha kinase. In general, this capability is evident among viruses that maintain long-term active or latent infections, and must therefore deal with interferon-induced antiviral responses of their hosts.
D000818:Animals; D002472:Cell Transformation, Viral; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D014780:Viruses / Q000235:genetics*
D012333:RNA, Messenger