Determination of platelet-megakaryocyte regeneration time in painters occupationally exposed to organic solvents.
An improved method for the determination of the regeneration time of human platelets is presented. The platelet-megakaryocyte regeneration times of painters exposed to organic solvents (n = 5; age range 23-48 years) were compared with a reference group (n = 5; age range 23-46 years) not occupationally exposed to solvents. After purification and extraction of the samples, they were analysed by high-performance liquid chromatography. The results showed that the painters have a shorter regeneration time (range 4.4-5.2 days) than the reference group (range 5.2-6.9 days) and indicate that solvent exposure may be associated with an increase in platelet turnover in man.
D000328:Adult; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood; D001241:Aspirin / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005231:Fatty Acids, Unsaturated / Q000097:blood; D006801:Humans; D008297:Male; D008533:Megakaryocytes / Q000187:drug effects* / Q000378:metabolism; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood*; D010150:Paint / Q000009:adverse effects*; D012997:Solvents / Q000009:adverse effects*; D013056:Spectrophotometry, Ultraviolet
D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D012997:Solvents; D016718:Arachidonic Acid; C008033:12-hydroxy-5,8,10-heptadecatrienoic acid; D001241:Aspirin