title: Analysis of HLA antigens in Japanese with oral lichen planus.
abstract: Analysis of HLA antigens was performed in 42 Japanese patients with oral lichen planus (OLP). There were no significant differences in the frequency of HLA-A, B, C antigens between OLP-patients and control subjects, although a decreasing trend in the frequency of Bw 52 and an increasing trend in that of Bw 61 and Cw 3 was noted. Among the HLA-DR and DQ antigens studied, the frequency of DRw 9 was significantly increased (Pc less than 0.05, RR = 3.3) and the relative risk was increased (RR = 6.0) when DRw 9 was carried on as a Bw 61/DRw 9 haplotype. Our results suggest that HLA-associated genetic factors play a role to some extent in the development of OLP.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006683:HLA-DQ Antigens / Q000032:analysis / Q000235:genetics; D006684:HLA-DR Antigens / Q000032:analysis / Q000235:genetics; D006801:Humans; D007564:Japan; D008010:Lichen Planus / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens