The effects of "yusho" type PCB on triglyceride lipase and fatty acid composition.
Yusho type polychlorinated biphenyl (Y-PCB) was prepared in order to study lipid disorder of the PCB poisoning "yusho." Y-PCB caused hypertriglyceridemia and hypercholesterolemia in the rat. Triglyceride lipase (TGL) activities in liver and postheparin serum were suppressed by Y-PCB administration, whereas it was not suppressed in fat. In in vitro experiments, Y-PCB did not suppress TGL in either liver or fat. Although Y-PCB increased fatty acids in the liver 2.5-fold, the relative proportion of fatty acids composition was not changed so remarkably as that in absolute concentrations. These findings suggested that liver is the target of Y-PCB -mediated alteration of lipid metabolism.
D000273:Adipose Tissue / Q000032:analysis; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005227:Fatty Acids / Q000032:analysis*; D008049:Lipase / Q000032:analysis*; D008099:Liver / Q000032:analysis / Q000187:drug effects; D008297:Male; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D005227:Fatty Acids; D011078:Polychlorinated Biphenyls; D008049:Lipase