Association between lupus anticoagulant and epilepsy.
Lupus anticoagulant associated with thrombocytopenia, thrombosis or recurrent abortions was diagnosed in 2 epileptic patients chronically treated with anticonvulsant drugs. The immunoglobulin fractions containing the anticoagulant activity were isolated and characterized. A search for lupus inhibitor was carried out in 96 consecutively examined patients, but no further cases were found. Although rarely, lupus anticoagulant and epilepsy may be associated. Whether lupus anticoagulant is causally related with epileptic seizures or secondary to the use of antiepileptic drugs remains to be established.
D000026:Abortion, Habitual / Q000150:complications; D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects; D001323:Autoantibodies / Q000032:analysis*; D001778:Blood Coagulation Disorders / Q000150:complications*; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D016682:Lupus Coagulation Inhibitor; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D013921:Thrombocytopenia / Q000150:complications; D013924:Thrombophlebitis / Q000150:complications
D000927:Anticonvulsants; D001323:Autoantibodies; D001779:Blood Coagulation Factors; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016682:Lupus Coagulation Inhibitor