High susceptibility of analbuminemic rats to gastric tumor induction by N-methyl-N'-nitro-N-nitrosoguanidine.
Analbuminemic rats were found to be highly susceptible to induction of gastric tumors by N-methyl-N'-nitro-N-nitrosoguanidine (67-83 micrograms/ml) given to the rats in drinking water for 32 weeks. The rats were sacrificed at experimental week 44. Gastric tumors were found in 12 of 17 analbuminemic rats (70%) and in 8 of 21 normal rats (38%). Intestinal tumors developed in 7 of 17 (41%) analbuminemic rats and in 9 of 21 (42%) normal rats.
D000818:Animals; D007414:Intestinal Neoplasms / Q000139:chemically induced; D008297:Male; D008769:Methylnitronitrosoguanidine; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000172:deficiency*; D013274:Stomach Neoplasms / Q000139:chemically induced*
D012709:Serum Albumin; D008769:Methylnitronitrosoguanidine