title: Dopamine-GABA interactions in the nucleus accumbens and lateral septum of the rat.
abstract: The relationships between dopaminergic afferents and GABAergic neurones were studied at the electron microscopic level in the rat lateral septum and nucleus accumbens by coupling 6-hydroxydopamine degeneration and gamma-aminobutyric acid (GABA) immunocytochemistry. Degenerating fibres were observed in the two regions making synaptic contact with GABA-immunoreactive and non-labelled cell bodies and dendrites. It is concluded that dopaminergic afferents to the septum and the nucleus accumbens contact, among others, a population of GABAergic cells. A similar route of regulation of the basalo-cortical and septo-hippocampal cholinergic pathways by dopaminergic afferents is proposed.
mesh_terms: D000818:Animals; D004298:Dopamine / Q000502:physiology*; D006892:Hydroxydopamines; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D009434:Neural Pathways / Q000648:ultrastructure; D009474:Neurons / Q000032:analysis / Q000145:classification* / Q000648:ultrastructure; D009714:Nucleus Accumbens / Q000032:analysis / Q000187:drug effects / Q000648:ultrastructure*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000648:ultrastructure*; D012688:Septum Pellucidum / Q000032:analysis / Q000648:ultrastructure*; D005680:gamma-Aminobutyric Acid / Q000032:analysis / Q000502:physiology*
chemical_list: D006892:Hydroxydopamines; D005680:gamma-Aminobutyric Acid; D016627:Oxidopamine; D004298:Dopamine