Modulation of the adherence of group A streptococci to murine cells.
The adherence of group A Streptococci to P388 cells increases after treatment with interferon-gamma; this enhancement is less when antifibronectin antibodies are used. In parallel, peritoneal murine elicited macrophages pretreated with fibronectin bind more bacteria. Moreover, two monoclonal antibodies obtained against group A Streptococci had different effects on the ability of microorganisms to adhere to phagocytic cells.
D000818:Animals; D000906:Antibodies; D000911:Antibodies, Monoclonal; D001422:Bacterial Adhesion; D002460:Cell Line; D005353:Fibronectins / Q000276:immunology / Q000378:metabolism* / Q000494:pharmacology; D007371:Interferon-gamma / Q000378:metabolism* / Q000494:pharmacology; D008264:Macrophages / Q000382:microbiology*; D051379:Mice; D013297:Streptococcus pyogenes / Q000378:metabolism / Q000502:physiology*
D000906:Antibodies; D000911:Antibodies, Monoclonal; D005353:Fibronectins; D007371:Interferon-gamma