Effect of food on the serum concentration profile of enteric-coated valproic acid.
We evaluated the effect of food on the serum concentration profile of enteric-coated divalproex sodium (EC-VPA) in six adult volunteers following a single dose and in six patients during chronic-dose administration. The results demonstrated a significant delay but no decrease in extent of EC-VPA absorption following administration with food. To monitor serum concentrations in patients receiving EC-VPA, consideration of sampling time in relation both to time of dose and meals is required.
D000328:Adult; D004435:Eating; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013608:Tablets, Enteric-Coated; D014635:Valproic Acid / Q000008:administration & dosage* / Q000097:blood
D013608:Tablets, Enteric-Coated; D014635:Valproic Acid