Effects of liposomes on permeability of various compounds through rabbit corneas.
The effects of multilamellar liposomes (neutral, negative and positive charge) on the permeability of a hydrophilic compound, a macromolecular compound and a lipophilic compound through the rabbit corneas in vitro were examined. The corneal permeability of liposomal entrapped 6-carboxyfluorescein (CF), a hydrophilic compound, did not change as compared with that of a CF solution in phosphate buffer saline (PBS, pH 7.4). Those of liposomal entrapped FITC-dextran (mol. wt 4000) and rhodamine B, a macromolecular compound and a lipophilic compound, respectively, decreased as compared with those of FITC-dextran and rhodamine B solutions (pH 7.4). In conclusion, liposomes did not increase the corneal permeabilities of these compounds.
D000111:Acetylcysteine / Q000378:metabolism; D000818:Animals; D003315:Cornea / Q000378:metabolism*; D016650:Fluorescein-5-isothiocyanate; D005452:Fluoresceins; D066298:In Vitro Techniques; D008081:Liposomes / Q000378:metabolism*; D010539:Permeability; D011817:Rabbits; D013861:Thiocyanates
D005452:Fluoresceins; D008081:Liposomes; D013861:Thiocyanates; C024098:6-carboxyfluorescein; D016650:Fluorescein-5-isothiocyanate; D000111:Acetylcysteine