Inhibition of hamster buccal pouch carcinogenesis by green coffee beans.
Forty female Syrian Golden hamsters were divided into two equal groups and placed on one of two diets. The hamsters in Group I received a normal chow, and the animals in Group II were given the same chow supplemented with powdered green coffee beans (20%). After the hamsters adjusted to the diets, 16 animals from each group were selected. The right buccal pouch of each of these hamsters was painted three times weekly with a 0.5% solution of 7, 12-dimethylbenz(a)anthracene (DMBA) in heavy mineral oil. The eight remaining animals, four in each group, served as controls and were treated three times weekly with heavy mineral oil. After a total of 50 treatments (16 1/2 weeks), the hamsters were killed. The animals receiving green coffee beans exhibited a significant delay in the development of DMBA-induced carcinogenesis of the buccal pouch mucosa, as determined by both visual and histologic examination.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors; D000818:Animals; D003069:Coffee; D006224:Cricetinae; D004224:Diterpenes / Q000494:pharmacology; D005260:Female; D008647:Mesocricetus; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D003069:Coffee; D004224:Diterpenes; D015127:9,10-Dimethyl-1,2-benzanthracene; C053401:kahweol; C053400:cafestol