A new IVIgG preparation (IVIgG pH 4.25): preliminary results for the treatment of immune thrombocytopenia.
Fifteen patients comprising ten with chronic idiopathic autoimmune thrombocytopenic purpura, three with acute autoimmune thrombocytopenic purpura, and two with secondary chronic autoimmune thrombocytopenic purpura were treated. All patients received 5-day courses of intravenous immunoglobulin (pH 4.25) at a dose of 400 mg kg body weight daily and five patients received maintenance treatment with double dose single infusions. Responses were seen in 12 patients which were in general of brief duration although one patient had a sustained remission. Five patients were treated with maintenance therapy of 800 mg/kg given at approximately 3-weekly intervals and maintained satisfactory platelet counts.
D001327:Autoimmune Diseases / Q000628:therapy*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000627:therapeutic use*; D016756:Immunoglobulins, Intravenous; D007262:Infusions, Intravenous; D010976:Platelet Count; D011696:Purpura, Thrombocytopenic / Q000628:therapy*
D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous