Mechanisms in the production of prepuberal reproductive defects in neonatal estrogenized male rats.
Neonatal estrogenization induced in prepubertal males atrophy of the testis and ventral prostate and increased the weight of the seminal vesicles. Atrophy of the testis was probably due to the inhibition of FSH and LH secretion: males estrogenized on day one and sacrificed daily from day six to day fifteen showed lower gonadotropin levels than their respective controls. In addition, daily FSH and LH administration (80 micrograms/100 g BW and 40 micrograms/100 g BW respectively) from day one to day fifteen increased testicular development more effectively in estrogenized than in control males and the differences between the two groups disappeared. Prostate atrophy was due to the decreased testosterone secretion. The reason for the hypertrophy of the seminal vesicles remains unclear: reduction in Prolactin levels due to bromocriptine treatment did not normalize the seminal vesicles weight, indicating that hyperprolactinemia was not the cause. Male rats estrogenized on day one, orchidectomized on day 5 and decapitated on day fifteen also showed hypertrophy in their seminal vesicles. These results indicate that testicular factors, other than testosterone, were not responsible for the vesicular hypertrophy. It seem possible that estrogens might act directly on vesicular growth.
D000311:Adrenal Glands / Q000033:anatomy & histology / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D001284:Atrophy; D001971:Bromocriptine / Q000494:pharmacology; D004822:Epididymis / Q000033:anatomy & histology / Q000187:drug effects / Q000473:pathology; D004967:Estrogens / Q000009:adverse effects*; D005640:Follicle Stimulating Hormone / Q000378:metabolism / Q000494:pharmacology; D005837:Genitalia, Male / Q000187:drug effects* / Q000473:pathology; D006984:Hypertrophy; D007986:Luteinizing Hormone / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000032:analysis; D011388:Prolactin / Q000032:analysis / Q000097:blood; D011467:Prostate / Q000033:anatomy & histology / Q000187:drug effects / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012669:Seminal Vesicles / Q000033:anatomy & histology / Q000187:drug effects / Q000473:pathology; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects / Q000473:pathology
D004967:Estrogens; D001971:Bromocriptine; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone