Genotoxicity of zineb detected through the somatic and germ-line mosaic assays and the sex-linked recessive-lethal test in Drosophila melanogaster.
The genotoxicity of zineb, a carbamate fungicide, has been tested through eye, wing and female germ line mosaic assays and the sex-linked recessive-lethal test in Drosophila melanogaster. Larvae of different instars, heterozygous for appropriate recessive genetic markers, were exposed to the fungicide in food for different durations of time. The adult eyes and wings were screened for induction of mosaic spots and the eggs laid by the females were checked for induction of female germ-line mosaicism. It is concluded that zineb is genotoxic to both somatic and germ-line cells of Drosophila.
D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics; D005260:Female; D005804:Genes, Lethal; D005808:Genes, Recessive; D007814:Larva / Q000187:drug effects; D008297:Male; D009030:Mosaicism; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D013859:Thiocarbamates / Q000633:toxicity*; D014921:Wings, Animal / Q000187:drug effects; D015038:Zineb / Q000633:toxicity*
D013859:Thiocarbamates; D015038:Zineb