A comparison of the renal actions of gamma-L-glutamyl-L-dopa and gamma-L-glutamyl-L-tyrosine in normal man.
1. The renal responses to the dipeptides gamma-L-glutamyl-L-dopa (gludopa) and gamma-L-glutamyl-L-tyrosine (glutyrosine) were compared when given intravenously in six normal male volunteers. 2. Gludopa is natriuretic and diuretic at a dose of 25 micrograms min-1 kg-1. At the same dose, glutyrosine had no effect on the volume or sodium content of the urine. 3. There was a 400-600-fold increase in urine dopamine output after gludopa; there was no conversion of glutyrosine to dopamine. 4. Gludopa significantly inhibited plasma renin activity, whereas with glutyrosine there was a non-significant increase. 5. Gludopa is a potent pro-drug for renal dopamine production and exerts natriuretic and hormonal effects. Glutyrosine appears to be inactive. The results support the contention that circulating L-dopa is the important physiological precursor for renal dopamine.
D000328:Adult; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D004151:Dipeptides / Q000493:pharmacokinetics / Q000494:pharmacology*; D004298:Dopamine / Q000652:urine; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D004364:Pharmaceutical Preparations; D011355:Prodrugs / Q000493:pharmacokinetics; D012083:Renin / Q000097:blood; D012964:Sodium / Q000652:urine
D004151:Dipeptides; D004364:Pharmaceutical Preparations; D011355:Prodrugs; C017342:gamma-glutamyl DOPA; D004295:Dihydroxyphenylalanine; C054674:gamma-glutamyltyrosine; D012964:Sodium; D012083:Renin; D004298:Dopamine