Synthesis and antimicrobial activity of some new 2-chloro-4-nitrobenzoylamino acid and dipeptide derivatives.
The synthesis of a series of 2-chloro-4-nitrobenzoylamino acid methyl esters (II-VIII), corresponding hydrazides (IX-XV), dipeptide methyl esters (XVI-XXII) and dipeptide hydrazides (XXIII-XXIX) was achieved employing the carbodiimide and azide methods. The derivatives containing the residues of Phe and Tyr were found to be active against several microorganisms.
D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001412:Bacillus subtilis / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009579:Nitrobenzoates / Q000138:chemical synthesis* / Q000494:pharmacology
D000577:Amides; D000900:Anti-Bacterial Agents; D004151:Dipeptides; D009579:Nitrobenzoates