title: [Inflammatory breast carcinoma--possibilities and results of surgical treatment and adjuvant chemotherapy, especially when done preoperatively].
abstract: The so-called "inflammatory" cancer represents a rare but fatal malignancy of the female breast, due to rapid growth and early dissemination. The traditional therapeutic approach, locoregional treatment at first, largely irradiation, but chemotherapy in disseminated disease only, results in a poor outcome: in our experience, all patients died within two years. Compared to it, reversal of treatment modalities, i.e. beginning with an aggressive mode of polychemotherapy, locoregional treatment postponed, does prolong disease-free and overall survival. The locoregional treatment consisted in our series in surgical procedures, predominantly extended radical mastectomy. The reason for this approach was twofold: a) no need to discontinue chemotherapy administration b) Involvement of internal mammary nodes (70%) 8/20 patients, treated 1979-1981, survive 60 months or more No advantage has been seen so far in cases with supraclavicular and/or disease beyond the involved breast. The traditional approach will be justified.
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D002277:Carcinoma / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008207:Lymphatic Metastasis; D008727:Methotrexate / Q000627:therapeutic use; D009362:Neoplasm Metastasis; D011300:Preoperative Care; D005641:Tegafur / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D005641:Tegafur; D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate
vernacular_title: Das inflammatorische Mammakarzinom--Möglichkeiten und Resultate operativer Behandlung bei adjuvanter Chemotherapie, insbesondere präoperativem Beginn.