Resistance of human bronchial epithelial cells to teleocidin in a two-stage carcinogenesis experiment.
The tumor-promoting activity of teleocidin in two-stage carcinogenesis was tested using human bronchi grafted into athymic nude mice. On treatment with 7,12-dimethylbenz(a) anthracene (DMBA) plus teleocidin, no bronchial carcinomas were produced in 44 grafted human bronchi, but 8 spindle cell sarcomas developed in mouse tissues. Application of DMBA to grafted human bronchi produced only 3 spindle cell sarcomas in the tissues of 30 mice. Application of teleocidin did not produce any tumors in 24 grafts of bronchi obtained from heavy smokers. Thus, teleocidin had an effect on mouse tissues, but seemed to have no effect on human bronchial cells, although it is uncertain whether the grafted human bronchi were initiated by DMBA.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000818:Animals; D001980:Bronchi / Q000187:drug effects* / Q000637:transplantation; D002273:Carcinogens / Q000494:pharmacology*; D004351:Drug Resistance; D004848:Epithelium / Q000187:drug effects / Q000637:transplantation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced / Q000209:etiology*; D008235:Lyngbya Toxins / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D012907:Smoking / Q000009:adverse effects; D014183:Transplantation, Heterologous
D002273:Carcinogens; D008235:Lyngbya Toxins; C022176:teleocidins; D015127:9,10-Dimethyl-1,2-benzanthracene