title: Functional monopolar spindles caused by mutation in mgr, a cell division gene of Drosophila melanogaster.
abstract: Mutation in the gene merry-go-round (mgr) of Drosophila causes a variety of phenotypic traits in somatic and germinal tissues, such as polyploid cells, metaphasic arrest, postmeiotic cysts with 16 nuclei, and spermatids with four times the normal chromosome content. The most characteristic phenotype is the appearance of mitotic and meiotic figures where all chromosomes are arranged in a circle. Treatment with anti-mitotic drugs and the phenotype of double mutants mgr asp (asp being a mutation altering the spindle) show that these circular figures need a functional spindle for their formation. These abnormal figures are caused by monopolar spindles similar to those observed after different treatments in several organisms. All mutant traits indicate that mgr performs a function necessary for the correct behaviour of centrosomes, thus opening this organelle to genetic analysis.
mesh_terms: D000818:Animals; D002455:Cell Division; D004331:Drosophila melanogaster; D005796:Genes; D008858:Microscopy, Phase-Contrast; D008938:Mitosis; D009154:Mutation; D008941:Spindle Apparatus / Q000502:physiology* / Q000648:ultrastructure