Midcycle changes of 17-OH-progesterone levels in women superovulated with clomiphene citrate and human menopausal gonadotropin for in vitro fertilization.
The dynamics of 17-alpha-hydroxy-progesterone (17-OHP) production during the onset of the luteinizing hormone (LH) surge were evaluated at 8-hour intervals and correlated with plasma estradiol (E2), LH, and progesterone (P) in 22 women superovulated for in vitro fertilization. Plasma 17-OHP levels rose 8 to 16 hours before the earliest rise in LH and P in 18% of patients, but had risen significantly in 82% of patients by the onset of the LH surge. In the late follicular phase, 17-OHP levels correlated significantly with E2 and LH levels, and the number of follicles greater than 10 mm. Because rising 17-OHP levels preceded the LH surge in only a few patients, it has no clinical value as a marker for human chorionic gonadotropin administration for timed oocyte recovery. Plasma 17-OHP levels, however, may complement LH levels better than P levels in determining the most appropriate stage for surge-timed oocyte retrieval.
D019326:17-alpha-Hydroxyprogesterone; D002996:Clomiphene / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D005498:Follicular Phase; D006801:Humans; D006908:Hydroxyprogesterones / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D008596:Menotropins / Q000627:therapeutic use*; D008597:Menstrual Cycle; D010060:Ovulation; D011374:Progesterone / Q000097:blood; D013480:Superovulation
D006908:Hydroxyprogesterones; D002996:Clomiphene; D011374:Progesterone; D004958:Estradiol; D008596:Menotropins; D019326:17-alpha-Hydroxyprogesterone; D007986:Luteinizing Hormone