Effect of misoprostol on fat malabsorption in cystic fibrosis.
Misoprostol, a synthetic prostaglandin that is known to reduce gastric acid production and stimulate duodenal bicarbonate production, was evaluated in 22 patients with cystic fibrosis. In those patients who had greater than 10% fat malabsorption while taking pancrease the addition of misoprostol significantly reduced the degree of fat malabsorption.
D000527:Alprostadil / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D016595:Misoprostol; D010194:Pancreatin / Q000627:therapeutic use
D000897:Anti-Ulcer Agents; D004041:Dietary Fats; D016595:Misoprostol; D010194:Pancreatin; D000527:Alprostadil