title: Structural relationships between senfolomycins and paulomycins.
abstract: Senfolomycins A and B (Antimicrob. Agents Chemother.-1965: 828-831, 1966) are two antibacterial agents with physico-chemical and biological properties similar to those of paulomycin. Recent studies indicate that senfolomycin A (C29H36N2O16S, MW 700) has molecular composition and fast atom bombardment MS fragmentation pattern identical to those of paulomycin E. Extensive NMR work indicates that the two antibiotics, which have been separated by HPLC and TLC, differ only in the stereochemistry of the OCH3 group present in their respective sugar moieties. Indirect evident suggests that senfolomycin B is dihydrosenfolomycin A (C29H38N2O16S, MW 702) and in this respect it is related to paulomycin F. The proposed structures for senfolomycins A and B are discussed.
mesh_terms: D000900:Anti-Bacterial Agents; D016227:Benzoquinones; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D053138:Cyclohexenes; D004187:Disaccharides / Q000302:isolation & purification / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects; D017879:Isothiocyanates; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D016227:Benzoquinones; D053138:Cyclohexenes; D004187:Disaccharides; D017879:Isothiocyanates; C055555:paulomycin E; C057565:senfolomycin A; C057566:senfolomycin B; C034569:paulomycin A