Lafora's disease and brain calcifications.
The brain from a 22-year-old man with progressive myoclonal epilepsy (Lafora's disease) was examined. Besides widespread inclusion bodies in the nerve cells calcifications were seen on the inner and outer surface of the brain. No gliosis was present but the astrocytes were enlarged. They were unrelated to the inclusion bodies, as demonstrated in combined stainings with glial fibrillary acidic protein (GFAP)-PAS or GFAP-Bodian. A transport of an abnormal metabolic product is suggested.
D000328:Adult; D001927:Brain Diseases / Q000150:complications* / Q000473:pathology; D002114:Calcinosis / Q000150:complications* / Q000473:pathology; D004831:Epilepsies, Myoclonic / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male