title: Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord.
abstract: Kelatorphan, a mixed inhibitor of "enkephalinases" is used for demonstrating the implication of endogenous enkephalins in nociceptive transmission at the spinal level.
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D004744:Enkephalin, Methionine / Q000502:physiology*; D066298:In Vitro Techniques; D007930:Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D009474:Neurons / Q000502:physiology; D010146:Pain / Q000503:physiopathology; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D015244:Thiorphan; D008625:Tiopronin / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000700:Analgesics; D004151:Dipeptides; C042591:kelatorphan; D004744:Enkephalin, Methionine; D015244:Thiorphan; D008625:Tiopronin; D007930:Leucine; C012211:ubenimex