Inhibition of leucocyte migration by cancer chemotherapeutic agents and its prevention by free radical scavengers and thiols.
The exposure of human blood in vitro to a range of concentrations of adriblastine, hydroxyurea, methotrexate, 5-fluorouracil, 6-mercaptopurine, cytosine arabinoside and nitrogen mustard induced reduction in leucocyte migration rate in all drug dilutions under study. The reduction was dose-dependent. This effect was used to examine the protection of alfa tocopherol, acetylosalicylic acid and thiourea against drug-induced cytotoxicity. It has been found that at the suitable concentration of the protecting agent, a preventive effect of tocopherol against toxicity of all drugs, except nitrogen mustard, can be achieved. Acetylosalicylic acid protected the cells against adriblastine, cytosine arabinoside, hydroxyurea and methotrexate toxicity. Thiourea prevented the toxic effect of adriblastine, fluorouracil, hydroxyurea, methotrexate and nitrogen mustard.
D000970:Antineoplastic Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D002464:Cell Migration Inhibition; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects* / Q000276:immunology; D013890:Thiourea / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
D000970:Antineoplastic Agents; D014810:Vitamin E; D013890:Thiourea; D001241:Aspirin