Pharmacological doses of calcitonin reduce sex hormone levels in rat plasma.
Administration of a pharmacological dose of salmon calcitonin into rats (10 MRC U/kg body weight) significantly reduced plasma concentrations of testosterone and estradiol in a time-dependent fashion. This apparently was mediated by a diminished secretion of luteinizing hormone and follicle-stimulating hormone, the levels of which were also significantly reduced after 1 h of calcitonin administration.
D000818:Animals; D002116:Calcitonin / Q000008:administration & dosage*; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000097:blood*
D013739:Testosterone; D004958:Estradiol; C028815:salmon calcitonin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002116:Calcitonin