Effects of thyrotrophin-releasing hormone on renal function in the rat.
Standard renal clearance techniques were used to investigate the acute effects of TRH on kidney function in anaesthetized rats. A significant reduction in salt and water outputs, glomerular filtration rate and renal plasma flow was produced within 10 min of infusion of 12 micrograms TRH over 30 min. The rapidity of the response may suggest a direct effect of TRH on the renal vascular system.
D000818:Animals; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D014556:Urine
D013973:Thyrotropin-Releasing Hormone