Acute and chronic effects of methsuximide and mephenytoin on the delayed-matching-to-sample performance of pigeons.
Acute and chronic effects of methsuximide and mephenytoin were examined in pigeons performing under a delayed-matching-to-sample procedure. Acute administrations of methsuximide (25-175 mg/kg) and mephenytoin (40-160 mg/kg) produced generally dose-dependent decreases in accuracy. At the two highest doses, methsuximide decreased rate of responding to the sample stimulus; mephenytoin did so only at the highest dose. At low doses, both methsuximide and mephenytoin increased response rate over control. After 20 sessions of daily exposure to methsuximide (100 mg/kg) or mephenytoin (80 mg/kg), tolerance developed to the accuracy-decreasing effects of both drugs.
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D010856:Columbidae; D006827:Hydantoins / Q000494:pharmacology*; D008570:Memory, Short-Term / Q000187:drug effects*; D008617:Mephenytoin / Q000494:pharmacology*; D013388:Succinimides / Q000008:administration & dosage / Q000494:pharmacology*
D000927:Anticonvulsants; D006827:Hydantoins; D013388:Succinimides; C100286:methsuximide; D008617:Mephenytoin