Ten years experience with a chemotherapy regime for ovarian cancer.
In the period between January 1973 and September 1982, 57 patients with advanced epithelial ovarian cancer were treated with a chemotherapy regime of methotrexate, thiotepa, and vincristine. A 5-year survival rate of 24.1% was obtained. The chemotherapy regime was based on the mode of drug action and information gained from experimental work on fresh explant cultures of human tumor. The regime was well tolerated and the survival rate is similar to results obtained from other regimes recently reported.
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D013852:Thiotepa / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D013852:Thiotepa; D008727:Methotrexate