Immunological blockade of endogenous thyrotropin-releasing hormone impairs recovery from hyperglycemia in mice.
Administration of antiserum to thyrotropin-releasing hormone (TRH) into the lateral cerebral ventricle of mice significantly attenuated recovery from hyperglycemia induced by treatment with 2-deoxyglucose but had no effect on the plasma glucose of saline-treated mice. TRH, injected centrally together with the anti-TRH antibody, reversed the effect of the antiserum and blocked the development of hyperglycemia. These findings suggest that activation of TRH neurons in the central nervous system may be a physiological event influencing recovery from hyperglycemia.
D000818:Animals; D001323:Autoantibodies / Q000494:pharmacology*; D003847:Deoxyglucose; D006943:Hyperglycemia / Q000139:chemically induced / Q000378:metabolism*; D007276:Injections, Intraventricular; D051379:Mice; D013973:Thyrotropin-Releasing Hormone / Q000276:immunology / Q000502:physiology*
D001323:Autoantibodies; D013973:Thyrotropin-Releasing Hormone; D003847:Deoxyglucose