Effects of the antimicrobic tiamulin on seven gram-negative bacterial fish pathogens.
In vitro and in vivo test were carried out with tiamulin and gram-negative bacterial pathogens of fish. Determination of minimum inhibitory concentration for 51 strains of seven species of gram-negative bacterial pathogens showed that only strains of Vibrio anguillarum were sensitive at 1.6-6.25 ppm, while the rest of test strains required 25- greater than 100 ppm. Control of infection was not achieved when tiamulin was fed for 14 days at 5 or 50 mg/kg to rainbow trout (Salmo gairdneri) experimentally infected with Yersinia ruckeri.
D000333:Aeromonas / Q000187:drug effects; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy / Q000662:veterinary*; D004224:Diterpenes / Q000494:pharmacology / Q000627:therapeutic use; D004755:Enterobacteriaceae / Q000187:drug effects; D005393:Fish Diseases / Q000188:drug therapy*; D005399:Fishes; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D011551:Pseudomonas fluorescens / Q000187:drug effects; D014337:Trout; D014733:Vibrio / Q000187:drug effects; D015007:Yersinia / Q000187:drug effects; D015009:Yersinia Infections / Q000188:drug therapy / Q000662:veterinary
D000900:Anti-Bacterial Agents; D004224:Diterpenes; C014224:tiamulin