Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go.
Potassium channels in neurons are linked by guanine nucleotide binding (G) proteins to numerous neurotransmitter receptors. The ability of Go, the predominant G protein in the brain, to stimulate potassium channels was tested in cell-free membrane patches of hippocampal pyramidal neurons. Four distinct types of potassium channels, which were otherwise quiescent, were activated by both isolated brain G0 and recombinant Go alpha. Hence brain Go can couple diverse brain potassium channels to neurotransmitter receptors.
D000266:Adenylyl Imidodiphosphate / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D004553:Electric Conductivity; D019204:GTP-Binding Proteins / Q000494:pharmacology*; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D007700:Kinetics; D046911:Macromolecular Substances; D008564:Membrane Potentials / Q000187:drug effects; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D011712:Pyramidal Tracts / Q000502:physiology; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology*
D046911:Macromolecular Substances; D015221:Potassium Channels; D011994:Recombinant Proteins; D000266:Adenylyl Imidodiphosphate; D019204:GTP-Binding Proteins