Adrenal cortex hormones in male epileptic patients before and during a 2-year phenytoin treatment.
Serum levels of progesterone, cortisol and phenytoin as well as the excretion of 17-OHCS were determined in 45 male epileptics before and during 24 months of the therapy. A significant decrease of the hormones was found in untreated patients. Phenytoin administration caused further decrease of cortisol and its metabolite 17-OHCS levels and a compensation of progesterone serum concentration.
D015065:17-Hydroxycorticosteroids / Q000097:blood; D000302:Adrenal Cortex / Q000187:drug effects; D000305:Adrenal Cortex Hormones / Q000097:blood*; D000328:Adult; D004828:Epilepsies, Partial / Q000188:drug therapy; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011374:Progesterone / Q000097:blood
D015065:17-Hydroxycorticosteroids; D000305:Adrenal Cortex Hormones; D011374:Progesterone; D010672:Phenytoin; D006854:Hydrocortisone