[Indicators of risk of reagin allergy. IV. HLA markers].
The concept of a genetic score was described in a previous publication by our group. It indicated that patient groups separated by this score may help to identify a possible genetic factor of allergic risk. In the present study, 1,800 children under the age of 13 were reviewed. Groups were classified by genetic score. The determination of loci A and B of HLA system was performed in 93 allergic children and revealed a highly significant correlation between HLA B12 and genetic score. On the other hand, the frequency of HLA A2 decreased with age. This fact can be interpreted as a prognostic indicator of allergic disease in children.
D000293:Adolescent; D002648:Child; D005260:Female; D005819:Genetic Markers; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D008297:Male; D010641:Phenotype; D011058:Pollen; D011379:Prognosis; D012204:Rh-Hr Blood-Group System / Q000235:genetics; D012307:Risk Factors
D005819:Genetic Markers; D006680:HLA Antigens; D012204:Rh-Hr Blood-Group System
Les indicateurs de risque de l'allergie réaginique. IV. Marqueurs de risque HLA.