[Effect of the antiserotoninergic preparation cyproheptadine on the levels of luteinizing and follicle-stimulating hormones and testosterone in patients with polycystic ovaries].
An antiserotoninergic drug cyproheptadine was administered to 10 patients at a dose of 4 mg per os to study LH, FSH and testosterone regulation in patients with polycystic ovaries. Blood samples were taken in the morning before, and 1 and 2 h after drug administration. A significant decrease in the level of testosterone (p less than 0.0001) in 1 and 2 h and a tendency to a decrease in the LH level and a LH/FSH ratio in 2 h after cyproheptadine administration were revealed. The effect of the drug on the FSH level was insignificant. A conclusion was made of the involvement of the serotoninergic mechanisms in the regulation of androgenic secretion in patients with polycystic ovaries.
D003533:Cyproheptadine / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy*; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
D003533:Cyproheptadine; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Vliianie antiserotoninergicheskogo preparata tsiprogeptadina na uroven' liuteiniziruiushchego, follikulostimuliruiushchego gormonov i testosterona u bol'nykh polikistozom iaichnikov.