Human granulocyte colony-stimulating factor produced by Escherichia coli shortens the period of granulocytopenia induced by irradiation in mice.
Daily administration of purified human granulocyte colony-stimulating factor produced by E. coli (Hu-G-CSF) accelerated the recovery from neutropenia induced by total-body irradiation in mice. Granulocyte-macrophage progenitors assayed as colony-forming unit granulocyte/macrophage (CFU-GM) in spleen were markedly increased in number by Hu-G-CSF, and the accelerated recovery from neutropenia may be due to the stimulation of granulocytopoiesis by the G-CSF from progenitor cells.
D000380:Agranulocytosis / Q000188:drug therapy*; D000818:Animals; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D007377:Interleukin-3 / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D013997:Time Factors
D007377:Interleukin-3