Cyclosporine-induced renal macroangiopathy.
Although nephrotoxicity secondary to cyclosporine (CsA) is common and has a predilection for arterioles, stenosis of the major renal artery or its primary branches has not yet been described as a manifestation of CsA toxicity. A case of a primary cadaveric renal transplant recipient treated with CsA who developed significant deterioration of renal function associated with angiographic evidence of high-grade stenosis of all three major branches of the renal artery that resolved completely after discontinuation of the drug is reported.
D000328:Adult; D000792:Angiography; D002102:Cadaver; D003524:Cyclosporins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D011866:Radioisotope Renography; D012078:Renal Artery Obstruction / Q000139:chemically induced* / Q000000981:diagnostic imaging; D015091:beta-Alanine / Q000031:analogs & derivatives
D003524:Cyclosporins; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; C054752:technetium TC 99m 2,3-diaminopropionic acid; D015091:beta-Alanine