Lupus anticoagulant: a unique case with lupus anticoagulant and habitual abortion together with antifactor II antibody and bleeding tendency.
Lupus anticoagulants (LA) are associated with various forms of thrombotic events. Of particular interest to obstetrics is the association with placental infarcts and habitual abortion. In the case described a near full-term viable infant was delivered subsequent to four early miscarriages. However, the mother had then developed an antifactor II antibody leading to grave hypoprothrombinemia with bleeding tendency, indicating efficient autoanticoagulation. This natural experiment indicates that these patients should receive anticoagulation during pregnancy, possibly in combination with steroids to depress the LA level.
D000026:Abortion, Habitual / Q000097:blood / Q000276:immunology*; D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D001778:Blood Coagulation Disorders / Q000097:blood / Q000276:immunology*; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology* / Q000502:physiology; D001780:Blood Coagulation Tests; D005260:Female; D006801:Humans; D007020:Hypoprothrombinemias / Q000276:immunology; D016682:Lupus Coagulation Inhibitor; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D011247:Pregnancy; D011516:Prothrombin / Q000276:immunology*
D001323:Autoantibodies; D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor; D011516:Prothrombin