Atropine is an inhibitor of the chemiluminescence induced by platelet-activating factor in human neutrophils.
Chemiluminescence provoked by platelet-activating factor can be dose-dependently inhibited by atropine. This effect of atropine is rather due to its ion channel blocking capability (at the higher doses than 10(-5) M) than to its action on the acethylcholine receptors. The differences in the roles of platelet-activating factor and acethylcholine in the activation of phagocytes are discussed.
D001285:Atropine / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D010972:Platelet Activating Factor; D001285:Atropine