Susceptibility of Neisseria gonorrhoeae to pefloxacin.
144 strains each of penicillinase producing (PPNG) and non-penicillinase producing (NPPNG) Neisseria gonorrhoeae were tested for susceptibility to pefloxacin. All isolates but one (99.65%) were susceptible to 0.06 mg/l. No significant difference was detected between the minimum inhibitory concentrations (MICs) of PPNG and NPPNG strains. The MIC50 and MIC90 of both types of strains were 0.015 mg/l and 0.06 mg/l respectively. Since pefloxacin was more effective than norfloxacin and rosoxacin against PPNG as well as NPPNG, it should prove useful in the therapy of gonorrhoea.
D042462:4-Quinolones; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000201:enzymology; D009643:Norfloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D015366:Pefloxacin; D010405:Penicillinase / Q000096:biosynthesis; D011804:Quinolines / Q000494:pharmacology; D015363:Quinolones
D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D011804:Quinolines; D015363:Quinolones; D015366:Pefloxacin; C021083:rosoxacin; D010405:Penicillinase; D009643:Norfloxacin