Recurrence of Listeria monocytogenes meningitis.
A case of Listeria monocytogenes meningitis in a 3-year-old boy which relapsed after chloramphenicol treatment is described. The patient was subsequently successfully treated with ampicillin and gentamicin and made a complete recovery. In vitro studies confirmed the inadequacy of chloramphenicol therapy. The value of combination therapy, as evidenced by chessboard and killing-curve techniques with the strain, is discussed.
D000667:Ampicillin / Q000627:therapeutic use*; D002675:Child, Preschool; D002701:Chloramphenicol / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D004347:Drug Interactions; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D008089:Listeria monocytogenes / Q000187:drug effects; D008297:Male; D008584:Meningitis, Listeria / Q000175:diagnosis / Q000188:drug therapy*; D012008:Recurrence
D004338:Drug Combinations; D005839:Gentamicins; D002701:Chloramphenicol; D000667:Ampicillin