Regulation of carboxypeptidase H by inhibitory and stimulatory mechanisms during neuropeptide precursor processing.
1. Carboxypeptidase H is one of several proteolytic processing enzymes required for conversion of large neuropeptide precursors into the small peptide neurotransmitters and hormones. 2. Because of the importance of posttranslational processing as a regulatory step for the production of active peptides, recent studies investigating control mechanisms for carboxypeptidase H (CPH) are reviewed. 3. Evidence is discussed which illustrates how CPH can be inhibited and activated. These findings suggest that a processing enzyme can play a role in the control of neuropeptide production. 4. It will be important in further studies to understand how the multiple processing enzymes--endopeptidase(s) and aminopeptidase, along with CPH--are coordinately regulated for the synthesis of active peptides.
D000313:Adrenal Medulla / Q000201:enzymology; D000818:Animals; D043423:Carboxypeptidase H; D002268:Carboxypeptidases / Q000378:metabolism* / Q000502:physiology; D002417:Cattle; D004745:Enkephalins / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*; D051381:Rats
D004745:Enkephalins; D011498:Protein Precursors; D002268:Carboxypeptidases; D043423:Carboxypeptidase H