Inhibition of hepatic glutathione S-transferases by a major endogenous ligand substance present in uremic serum.
A major endogenous ligand substance present in uremic serum, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, inhibited the in vitro activity of bovine and rat liver glutathione S-transferases. Our results suggested that endogenous ligand substances retained in uremic serum have some toxic activities other than the inhibition of drug binding to serum protein observed in uremia.
D000818:Animals; D002417:Cattle; D004137:Dinitrochlorobenzene / Q000494:pharmacology; D005663:Furans; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors*; D006801:Humans; D007200:Indican / Q000494:pharmacology; D007210:Indoleacetic Acids / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D011422:Propionates / Q000097:blood*; D011485:Protein Binding; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism; D014511:Uremia / Q000097:blood*
D004137:Dinitrochlorobenzene; D005663:Furans; D007210:Indoleacetic Acids; D011422:Propionates; D012709:Serum Albumin; C030737:indoleacetic acid; C041693:3-carboxy-4-methyl-5-propyl-2-furanpropionic acid; D005982:Glutathione Transferase; D007200:Indican