[MHC restriction of the anti-allotypic response of T-lymphocytes in vitro].
In vitro MHC restriction of antigen-specific T-cell proliferation to Igk-Ib allotype of Igk chain has been studied in inbred August rats, using polyclonal and monoclonal antibodies to RT-1 molecules. Igk-1b-specific proliferation of immune T cells was completely abrogated by alloantiserum specific for RT-1c (August) molecules. Monoclonal antibodies (MAb) to RT-1B ("1-A-like") molecules inhibited markedly the response (about 70-80% inhibition), while anti-RT-ID ("I-E-like") MAb caused but weak inhibition (about 25%). Thus, the data obtained demonstrate RT-1Bc molecule as a main restriction element of Igk-1b-specific T-cell response.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D005260:Female; D007106:Immune Sera / Q000276:immunology; D007126:Immunoglobulin Allotypes / Q000276:immunology*; D007145:Immunoglobulin kappa-Chains / Q000276:immunology; D066298:In Vitro Techniques; D008285:Major Histocompatibility Complex; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D007106:Immune Sera; D007126:Immunoglobulin Allotypes; D007145:Immunoglobulin kappa-Chains
MHC-restriktsiia antiallotipicheskogo otveta T-limfotsitov in vitro.