Effects of interferon-gamma treatment on surgically simulated wound infection in mice.
Interferon-gamma (IFN-gamma) has been shown to have immunoregulatory properties and is able to modulate resistance to several microbial infections. This study was designed to determine the efficacy of IFN-gamma treatment in a mouse model of infection that simulates many clinical conditions associated with surgical wound infection: viz, a bacteria laden suture and tissue injury. The test bacteria were Klebsiella pneumoniae. Groups of CBA/J mice received either IFN-gamma or RPMI-1640 medium (controls) subcutaneously. IFN-gamma was administered daily at a dose of 7500 units for 5 days prior to bacterial challenge. Mice treated with IFN-gamma survived significantly longer than controls. Systemic bacterial recovery was significantly reduced in the IFN-gamma treated group but local bacterial recovery was unaffected.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D007371:Interferon-gamma / Q000627:therapeutic use*; D007710:Klebsiella Infections / Q000188:drug therapy; D007711:Klebsiella pneumoniae; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013530:Surgical Wound Infection / Q000628:therapy*; D013537:Sutures
D000276:Adjuvants, Immunologic; D007371:Interferon-gamma