Studies on the biosynthesis of beta-amino acids, the lipid moiety of iturins A, in Bacillus subtilis.
The biosynthesis of the beta-amino acid components of iturins A was studied in comparison to the biosynthesis of fatty acids. Palmitic acid was incorporated into the lipid moiety of iturins A when it was added to the culture medium of the iturin producer Bacillus subtilis. Addition of unlabeled palmitic acid enhanced the formation of straight-chain beta-amino acids and addition of valine or leucine increased the production of branched beta-amino acids. These modifications correlated with modifications in the corresponding biosynthesized fatty acids.
D000900:Anti-Bacterial Agents; D001412:Bacillus subtilis / Q000187:drug effects / Q000378:metabolism*; D002250:Carbon Radioisotopes; D007532:Isoleucine / Q000494:pharmacology; D007930:Leucine / Q000494:pharmacology; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000096:biosynthesis*; D010455:Peptides; D010456:Peptides, Cyclic / Q000096:biosynthesis* / Q000302:isolation & purification; D014633:Valine / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002250:Carbon Radioisotopes; D010169:Palmitic Acids; D010455:Peptides; D010456:Peptides, Cyclic; D007532:Isoleucine; D019308:Palmitic Acid; C013579:iturin A; D007930:Leucine; D014633:Valine