Study of the genotoxic potential of 48 inorganic derivatives with the SOS chromotest.
The genotoxic potential of 48 inorganic derivatives was studied using the bacterial colorimetric assay: the SOS Chromotest. Some of these compounds are known as carcinogens (As, CR(VI), Cd, Ni) or suspected carcinogens for human beings (Hg, Pb), others are known as non-carcinogens. Among these 48 derivatives, only the two Cr(VI) compounds and the Sn(II) compounds gave positive results.
D000818:Animals; D001426:Bacterial Proteins / Q000032:analysis; D001711:Biotransformation; D002273:Carcinogens / Q000494:pharmacology; D003124:Colorimetry; D004260:DNA Repair / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects*; D005189:False Positive Reactions; D005798:Genes, Bacterial; D008670:Metals / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests / Q000379:methods; D013014:SOS Response, Genetics / Q000187:drug effects*; D012492:Salts / Q000494:pharmacology*; D001616:beta-Galactosidase / Q000032:analysis
D001426:Bacterial Proteins; D002273:Carcinogens; D008670:Metals; D012492:Salts; D001616:beta-Galactosidase