Acquired immunodeficiency syndrome and concomitant non-Hodgkin's lymphoma in a patient with new chromosomal abnormality.
A case of an intravenous drug user who, over the course of less than 18 months, was diagnosed as having multiple opportunistic infections, the acquired immunodeficiency syndrome (AIDS) and a non-Hodgkin's lymphoma is presented. Cytogenetic findings on both bone marrow and lymph nodes revealed a consistent translocation involving chromosome 10 and 14 with trisomy for chromosomes 7 and 12, i.e. 48,XX,+7,+12,t(10,14) (q24;q32) in lymph node and bone marrow cells. These are abnormalities which heretofore have not been reported. Peripheral blood lymphocytes after PHA stimulation revealed a normal 46,XX karyotype. The number of reports describing cytogenetic findings in AIDS patients are limited. However, as there are a number of recurring, consistent chromosomal abnormalities in neoplasia, patients with AIDS should also be evaluated for chromosomal aberrations, especially in light of the increased number of secondary malignancies being described in such patients. It would be of great clinical importance to report as many chromosomal abnormalities as are found in this cohort of patients whose clinical outlook is so apparently poor.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D002869:Chromosome Aberrations / Q000150:complications* / Q000235:genetics; D025063:Chromosome Disorders; D002879:Chromosomes, Human, Pair 10; D002881:Chromosomes, Human, Pair 12; D002883:Chromosomes, Human, Pair 14; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007621:Karyotyping; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D014178:Translocation, Genetic; D014314:Trisomy