Malignant histiocytosis with rearrangement of the heavy chain gene and evidence of monocyte-macrophage lineage.
A unique case of malignant histiocytosis (MH) is reported. Its origin from the monocyte-macrophage system was indicated by expression of highly specific myeloid cell markers (My4, MCS2, and cytoplasmic lysozyme), diffuse activity of acid phosphatase and NaF-sensitive alpha-naphthyl acetate esterase, lack of immunologic markers specific for other cell lineages, and germ line configuration of the immunoglobulin light chain gene and the T-cell receptor beta-chain gene. Its neoplastic nature was suggested by the single rearranged band of the immunoglobulin heavy chain gene.
D000328:Adult; D001853:Bone Marrow / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D054747:Histiocytic Sarcoma / Q000235:genetics*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007150:Immunohistochemistry; D008264:Macrophages / Q000276:immunology* / Q000648:ultrastructure; D009000:Monocytes / Q000276:immunology* / Q000648:ultrastructure
D004273:DNA, Neoplasm; D007143:Immunoglobulin Heavy Chains