Testosterone implants into the lateral septum of male rats, a positive effect on LH and FSH secretion.
After two days, testosterone implanted into the lateral septum increased serum levels of LH and FSH in male Wistar rats. As measured by RIA, LH in animals with testosterone implanted in them in comparison to those with an empty cannula was 0.220 +/- 0.015 vs. 0.111 +/- 0.019 ng/ml; p less than 0.001 and FSH was 3.20 + 0.21 vs. 1.50 + 0.21 ng/ml; p less than 0.001. Serum testosterone was not increased to a statistically significant extent by the implants (4.12 +/- 0.54 vs. 2.87 +/- 0.42 ng/ml; ns). It was concluded that testosterone or possibly one of its metabolites acting in the lateral septum facilitates the release of LH and FSH.
D000818:Animals; D004343:Drug Implants; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012688:Septum Pellucidum / Q000187:drug effects* / Q000378:metabolism; D013739:Testosterone / Q000494:pharmacology*
D004343:Drug Implants; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone