No evidence for gamma-interferon mediated haematopoietic inhibition by T cells in aplastic anaemia: an observation in the course of immunosuppressive therapy.
Two patients with aplastic anaemia were treated with immunosuppressive agents and peripheral blood T cells were cryopreserved serially. Inhibitory activity of T cells to autologous CFU-E, gamma-IFN production by T cells and T cell subpopulations were assayed after remission. Inhibitory activity to autologous CFU-E was not correlated with the numbers or ratios of T cell subpopulations. gamma-IFN production by T cells were within the normal range when inhibitory activity was found. In addition, gamma-IFN production increased after haematopoietic recovery. These findings suggest that gamma-IFN is not a soluble mediator of T cell-mediated haematopoietic inhibition in aplastic anaemia.
D000293:Adolescent; D000741:Anemia, Aplastic / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D003114:Colony-Forming Units Assay; D005260:Female; D006410:Hematopoiesis; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000378:metabolism*; D008297:Male; D013601:T-Lymphocytes / Q000502:physiology*
D007166:Immunosuppressive Agents; D007371:Interferon-gamma