[Functional status of beta-cells of the pancreas in long-term administration of hypoglycemic sulfanilamides in patients with glucose tolerance disorder].
The levels of immunoreactive insulin and C-peptide were determined against a background of the GTT and GTT + prednisolone in patients with glucose intolerance before and 3-6 mos. after sulfanilamide therapy to study the effect of a prolonged use of glibenclamide (manilil) on compensatory-reserve function of beta-cells. The hypoglycemic effect of these drugs was determined by their extrahepatic action. The normalization of the body sensitivity to insulin was established. A prolonged use of sugar lowering sulfanilamides did not make a depleting effect on beta-cell function. The results obtained were in favor of the administration of glibenclamide to patients with disturbed glucose tolerance.
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005951:Glucose Tolerance Test; D005905:Glyburide / Q000008:administration & dosage*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000503:physiopathology*
D001786:Blood Glucose; D007328:Insulin; D005905:Glyburide
Funktsional'noe sostoianie beta-kletok podzheludochnoĭ zhelezy pri dlitel'nom primenenii sakharoponizhaiushchikh sul'fanilamidov u lits s narushennoĭ tolerantnost'iu k gliukoze.