Contribution of cardiogenic oscillations to gas exchange in constant-flow ventilation.
The contribution of cardiogenic oscillations to gas exchange during constant-flow ventilation was examined in 11 dogs. With the use of two variations of cardiopulmonary bypass to maintain the systemic and pulmonary circulation, the influence of cardiogenic oscillations was removed by arresting the heart. Cardiac arrest by ventricular fibrillation was associated with a mean decrease in alveolar ventilation of 43% in five dogs on right and left heart bypass. However, successful defibrillation and return of the prearrest level of alveolar ventilation could not be achieved; thus we studied six dogs on left heart bypass. Alveolar ventilation decreased an average of 37% with cardiac arrest, and defibrillation resulted in a return of alveolar ventilation to 81% of the prearrest value. These results are consistent with previous predictions that cardiogenic oscillations are an important mechanism of gas transport during constant-flow ventilation.
D000818:Animals; D001696:Biomechanical Phenomena; D002245:Carbon Dioxide; D002315:Cardiopulmonary Bypass; D004285:Dogs; D006321:Heart / Q000502:physiology*; D011650:Pulmonary Alveoli / Q000502:physiology; D011659:Pulmonary Gas Exchange; D012121:Respiration, Artificial / Q000379:methods*
D002245:Carbon Dioxide