Disseminated tuberculosis complicated by the hemophagocytic syndrome.
A 43-year-old Polynesian presented with fever, abnormal liver function tests, bilateral pulmonary infiltrates, and a progressive neutropenia and thrombocytopenia. Bone marrow examination showed extensive and striking hemophagocytosis which raised the diagnosis of malignant histiocytosis. Mycobacterium tuberculosis was subsequently cultured from both urine and bone marrow. Hemophagocytosis is now a recognised association of several infections and we draw attention to this finding, particularly as the confident exclusion of malignancy can be very difficult and management is obviously very different.
D000328:Adult; D001853:Bone Marrow / Q000473:pathology*; D006644:Histiocytes / Q000473:pathology / Q000502:physiology*; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D010587:Phagocytosis; D014376:Tuberculosis / Q000097:blood / Q000473:pathology*