Stimulation of calcitonin secretory capacity by increased serum levels of testosterone in men treated with tamoxifen.
Previous studies have suggested that sex steroids, including both oestrogen and testosterone, influence calcitonin secretion. However, a negative effect of gonadotrophins on calcitonin has not been excluded. Twelve men with infertility and low-normal serum levels of testosterone were studied before and during tamoxifen therapy. Increases in the serum levels of LH, FSH, testosterone and calcitonin were observed after treatment. Our findings suggest that testosterone has a direct influence on calcitonin secretion.
D002116:Calcitonin / Q000378:metabolism*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000097:blood / Q000188:drug therapy; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D013629:Tamoxifen / Q000627:therapeutic use*; D013739:Testosterone / Q000097:blood*
D013629:Tamoxifen; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002116:Calcitonin