HIV-antibody seroconversions in Dutch haemophiliacs using heat-treated and non heat-treated coagulation factor concentrates.
A national multicentre study was performed to investigate the effects of donorselection and the use of heat-treated plasma products on seroconversion to HIV in 157 Dutch haemophiliacs. All patients included in the study were seronegative for HIV antibodies in 1983. Thirteen percent (20/157) seroconverted between 1983 and 1986. Nineteen of 20 seroconversions could be related to the use of non heat-treated products in the year preceding HIV antibody seroconversion. One seroconversion occurred in a person using heat-treated non donor screened product. Seroconversion rate decreased as a result of the policy to discourage high risk blood donors and no seroconversions were observed following the introduction of donor screening in 1985.
D001779:Blood Coagulation Factors / Q000009:adverse effects*; D005169:Factor VIII / Q000627:therapeutic use; D005500:Follow-Up Studies; D006679:HIV Seropositivity / Q000453:epidemiology / Q000209:etiology*; D006467:Hemophilia A / Q000628:therapy*; D006358:Hot Temperature; D006801:Humans; D015337:Multicenter Studies as Topic; D009426:Netherlands
D001779:Blood Coagulation Factors; D005169:Factor VIII