Effect of a topical drug combination on the early healing of extraction sockets in the vervet monkey.
An animal trial was undertaken in 9 vervet monkeys to test the effect of a medicament combination on extraction socket healing. All 4 third molar teeth were extracted and 2 of the sockets in each animal were packed with Gelfoam sponge impregnated with a medicament containing a local anaesthetic, antiseptic, 2 potent antifibrinolytic agents and metronidazole. The remaining 2 sockets acted as controls: one of the sockets was packed with Gelfoam sponge alone and the other allowed to heal spontaneously with no implant. The healing of these sockets was evaluated histometrically in 4-, 6- and 8-day specimens, and from the results it was concluded that sockets containing the medicament compound showed enhanced early socket healing.
D000287:Administration, Topical; D000539:Alveolar Process / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D002522:Chlorocebus aethiops; D003992:Dibucaine / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D005781:Gelatin Sponge, Absorbable; D006847:Hydrocarbons, Iodinated / Q000627:therapeutic use; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D010226:Parabens / Q000627:therapeutic use; D014081:Tooth Extraction; D014148:Tranexamic Acid / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*
D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D006847:Hydrocarbons, Iodinated; D010226:Parabens; D008795:Metronidazole; D014148:Tranexamic Acid; C010473:iodoform; D003992:Dibucaine; C006068:propylparaben