[Basic phospholipase from the venom of Naja nigricollis is cytotoxic].
The basic phospholipase A2 purified from the venom of Naja nigricollis (Institut Pasteur), possesses an intense cytotoxic activity toward fetal cells from FL strain. At a concentration equal to 1.6 x 10(-6) M, the PLA2 lyses 50% of the cells present in a suspension containing 3.5 x 10(6) cells per millilitre. Other PLA2 from various origins do not exhibit such cytotoxic activity.
D000650:Amnion; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004546:Elapid Venoms / Q000633:toxicity*; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D010740:Phospholipases / Q000633:toxicity*; D010741:Phospholipases A / Q000302:isolation & purification / Q000633:toxicity*; D054467:Phospholipases A2
D004546:Elapid Venoms; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2
La phospholipase basique du venin de Naja nigricollis est cytotoxique.