Immunohistochemical detection of cathepsin D in human neuroontogenesis.
An antiserum against rat liver cathepsin D, which was previously found to cross-react with human brain cathepsin(s) D, was used to immunolocalize the enzyme in developing CNS man. Cathepsin D protein was found in neurons as well as in glial cells. The aerliest occurrence of cathepsin D was observed in neuroblasts at the 12th gestational week. During pre-, peri-, and postnatal neuroontogenesis, there is a strong increase in the amount of immunoreactive material.
D001921:Brain / Q000166:cytology / Q000196:embryology* / Q000201:enzymology; D002402:Cathepsin D / Q000276:immunology / Q000378:metabolism*; D005333:Fetus; D006801:Humans; D007106:Immune Sera; D007150:Immunohistochemistry; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology* / Q000201:enzymology
D007106:Immune Sera; D002402:Cathepsin D