title: Effects of dimethyl sulphoxide on the synthesis of plasma proteins in the human hepatoma HepG2. Induction of an acute-phase-like reaction.
abstract: Effects of dimethyl sulphoxide (Me2SO) on the synthesis of plasma proteins by the human hepatoma cell line HepG2 were examined. Me2SO treatment resulted in decreased synthesis of albumin and alpha-fetoprotein, and in increased synthesis of haptoglobin. Plasma-protein profiles induced by Me2SO treatment were very similar to those seen in acute-phase reactions.
mesh_terms: D000210:Acute-Phase Reaction / Q000139:chemically induced / Q000378:metabolism*; D000418:Albumins / Q000096:biosynthesis; D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis*; D002460:Cell Line; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
chemical_list: D000418:Albumins; D001798:Blood Proteins; D004121:Dimethyl Sulfoxide