[Inhibition of arachidonic acid-induced ear edema in the mouse with lipoxygenase-, cyclo-oxygenase- and dual inhibitors].
The ear edema of the mouse induced by local application of arachidonic acid is suitable for in vivo differentiation of lipoxygenase (LOX) and cyclooxygenase (COX) inhibitors. LOX blockers inhibit initially and plateau-like during the first hour of the course of the edema, while COX-blockers do so mostly only initially. For practice we recommend the measurement about 60 min following edema provocation. The dual blocker of LOX and COX, BW 755 c, acts like a LOX inhibitor.
D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors* / Q000633:toxicity; D016861:Cyclooxygenase Inhibitors; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D066298:In Vitro Techniques; D016859:Lipoxygenase Inhibitors; D051379:Mice; D011720:Pyrazoles / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D011720:Pyrazoles; D016718:Arachidonic Acid; D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
Hemmung des Arachidonsäure-induzierten Ohrödems der Maus durch Lipoxygenase-,Cyclooxygenase- und Dualhemmer.