[Modification of intestinal colonization and translocation of Campylobacter jejuni by erythromycin and an extract of Lactobacillus acidophilus in axenic mice].
Erythromycin (15 mg) or lyophylized heat-killed Lactobacillus acidophilus (80 mg) were administered per os daily in germ-free mice infected at day O with 10(7)-10(8) Campylobacter jejuni per os. Bacterial colonization of intestine and bacterial translocation of C. jejuni toward mesenteric lymph nodes, blood and liver were then studied for 5 days. The results were compared with those from an infected untreated control group. Compared to the control group, the numbers of free and mucosa-associated bacteria decreased at day 5 in the erythromycin-treated group and the number of mucosa-associated bacteria was reduced from day 1 to day 5 in the Lactobacillus-treated group. Both treatments reduced the frequency of bacterial translocation toward mesenteric lymph nodes from day 1 to day 5. We concluded that both erythromycin and heat-killed L. acidophilus are effective in treating Campylobacter infection in mice, though probably through different mechanisms.
D000818:Animals; D001769:Blood / Q000382:microbiology; D002169:Campylobacter Infections / Q000188:drug therapy / Q000628:therapy; D002168:Campylobacter fetus / Q000187:drug effects* / Q000302:isolation & purification; D003106:Colon / Q000382:microbiology; D004917:Erythromycin / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005856:Germ-Free Life; D007082:Ileum / Q000382:microbiology; D007413:Intestinal Mucosa / Q000382:microbiology; D007422:Intestines / Q000382:microbiology*; D007779:Lactobacillus acidophilus; D008099:Liver / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D008643:Mesentery / Q000382:microbiology; D051379:Mice; D008809:Mice, Inbred C3H
D004917:Erythromycin
Modification par l'érythromycine et un extrait de Lactobacillus acidophilus de la colonisation de l'intestin et de la translocation de Campylobacter jejuni chez la souris axénique.