[Dynamics of the cerebral blood flow and reactivity of the cerebral vessels after bilateral occlusion of the carotid arteries].
A model of cerebral ischemia was implemented by means of bilateral occlusion of carotid arteries in rabbits. A reduction of the blood flow was observed during first 3 days after the occlusion in the cortex and white matter, followed by a slow restoration up to 80 per cent of initial level. The responses of the blood flow to CO2 were reduced and often inverted during the 1st week, had a phasic character and returned to near normal by the 14th day. The responsiveness of vessels to CO2 and head-down tilt were sharply reduced and inverted during the 1st week and did not return to normal. Simultaneous recording of the blood flow parameters and of the responsiveness of cerebral vessels provides a better insight into the dynamics of postischemic restoration of functional state of various parts of the brain vascular system.
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology; D002245:Carbon Dioxide / Q000494:pharmacology; D002339:Carotid Arteries / Q000502:physiology*; D002536:Cerebral Arteries / Q000187:drug effects / Q000502:physiology*; D002550:Cerebral Veins / Q000187:drug effects / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D008026:Ligation; D011187:Posture; D011817:Rabbits; D013997:Time Factors
D002245:Carbon Dioxide
Dinamika mozgovogo krovotoka i reaktivnosti tserebral'nykh sosudov posle dvukhstoronneĭ okkliuzii sonnykh arteriĭ.