title: The carpal tunnel syndrome in hypertensive patients treated with beta-blockers.
abstract: We report the development of the carpal tunnel syndrome in 3 hypertensive men (aged 46-58) treated with beta-blockers (propranolol in two patients and metoprolol in the 3rd) for 8-11 years. Known causes of carpal tunnel syndrome were excluded in each case. Withdrawal of the beta-blocker was followed by complete resolution of symptoms and signs after a period of 8-10 weeks. No evidence of recurrence could be detected during follow-up of 7-18 months. The possible mechanisms of drug-induced carpal tunnel syndrome are briefly discussed.
mesh_terms: D000328:Adult; D002349:Carpal Tunnel Syndrome / Q000139:chemically induced*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D011433:Propranolol