Controlled trial of intravesical noxythiolin in the prevention of infection following outflow tract surgery.
A randomised control trial was undertaken in 100 consecutive patients undergoing endoscopic surgery for outflow tract obstruction to assess the efficacy of noxythiolin in preventing post-operative bacteriuria; 1% noxythiolin or sterile water was instilled at the time of catheter removal. The incidence of bacteriuria in the treated group (7/50) was significantly lower than in the control group (19/50). This was statistically significant. This difference was more marked in patients who had been catheterised for retention of urine. There was no difference in the complication rate despite a reduction of infection in the treated group.
D000283:Administration, Intravesical; D000368:Aged; D000369:Aged, 80 and over; D001437:Bacteriuria / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D006801:Humans; D008875:Middle Aged; D009677:Noxythiolin / Q000008:administration & dosage / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D013890:Thiourea / Q000031:analogs & derivatives*; D014524:Urethral Obstruction / Q000601:surgery*; D001748:Urinary Bladder Neck Obstruction / Q000601:surgery*
D009677:Noxythiolin; D013890:Thiourea