Antitumor effects of polysaccharides of human-type Mycobacterium tuberculosis on collagenation in human cancer xenografts.
The most important activity of SSM is stimulation of collagenation from cancer-infiltrated stromal tissue which confines the cancer. In order to elucidate the proliferative responses of collagen in cancer, single and double xenografts were prepared by transplantation of human gastric cancer (HGC), human lung cancer (HLC), and NB41A3 (mouse neuroblastoma) into nude mice. The collagen responses were dependent on the type of cancer cell used, particularly the cell membranes. SSM distinctly stimulated the proliferation of collagen fibers which showed a response to these cancer cells. When examined by CD, stromal collagenation was found to be dependent upon changes in the molecular structure of the cancer cell membrane. One of the glycoproteins, fibronectin, was presumed to be the most important of the substances involved.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002942:Circular Dichroism; D003094:Collagen / Q000378:metabolism*; D005347:Fibroblasts; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D009368:Neoplasm Transplantation; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology*
D000970:Antineoplastic Agents; D011135:Polysaccharides, Bacterial; D003094:Collagen