Dopamine synthesis in rat striatum: mobilization of tyrosine from non-dopaminergic cells.
Unilateral nigrostriatal lesions in rats that almost totally depleted striatal dopamine had no effect on striatal levels of dopamine's precursor, tyrosine, nor on those of leucine. Since prolonged electrical stimulation of the slices markedly depletes them of tyrosine (1,2) we conclude that tyrosine can be mobilized from non-dopaminergic striatal cells to augment dopamine release.
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000096:biosynthesis*; D004558:Electric Stimulation; D006892:Hydroxydopamines / Q000494:pharmacology; D007930:Leucine / Q000378:metabolism; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology; D014443:Tyrosine / Q000378:metabolism*
D006892:Hydroxydopamines; D014443:Tyrosine; D016627:Oxidopamine; D007930:Leucine; D004298:Dopamine