Endorphins contribute to the loss of glucose homeostasis in anaphylactic shock.
Central injection of naloxone attenuated the development of hyperglycemia following induction of non-fatal anaphylaxis in mice, but it failed to reverse the hyperglycemia in this model. In contrast, central TRH both blocked as well as reversed the hyperglycemic response. These results suggest a possible role for central endorphin mechanisms in the hyperglycemic response to anaphylactic shock in mice. Further, they demonstrate a novel action of TRH to block shock-induced hyperglycemia. This antihyperglycemic action of TRH is independent of opiate mechanisms.
D000707:Anaphylaxis; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004723:Endorphins / Q000502:physiology*; D006706:Homeostasis / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology
D001786:Blood Glucose; D004723:Endorphins; D009270:Naloxone; D013973:Thyrotropin-Releasing Hormone