Efficacy of low doses of praziquantel for Schistosoma mansoni and S. haematobium.
The shortage of available information on the impact of low doses of praziquantel was remedied by a trial of 0, 10, 20, 30 and 40 mg kg-1 against double infections of Schistosoma haematobium and S. mansoni in a rural area of Zimbabwe. No significant differences were found in egg reduction between 20-40 mg kg-1 for S. haematobium and between 30-40 mg kg-1 for S. mansoni. It is suggested that morbidity control can be achieved with lower dosages of praziquantel than currently recommended.
D000293:Adolescent; D000818:Animals; D002648:Child; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010270:Parasite Egg Count; D011223:Praziquantel / Q000008:administration & dosage*; D012548:Schistosoma haematobium / Q000187:drug effects*; D012550:Schistosoma mansoni / Q000187:drug effects*; D012553:Schistosomiasis haematobia / Q000188:drug therapy / Q000469:parasitology; D012555:Schistosomiasis mansoni / Q000188:drug therapy / Q000469:parasitology; D013997:Time Factors; D015030:Zimbabwe
D011223:Praziquantel