Caloric supply in parenteral nutrition in the stress phase.
Due to the metabolic alterations following surgery, glucose is not completely oxidized but is converted into glycogen and lipids. Therefore we analysed 2 groups of 15 patients following surgery. They received parenteral nutrition with identical nitrogen (N = 0.28 g/kg/d) and lipid (1.5 g/kg/d) intake, whereby only the composition of carbohydrates was varied. Group I received exclusively glucose = 0.22 g/kg/h, and group II the combination fructose-glucose-xylitol in a proportion of 2:1:1 at the same infusion rate. The study lasted approximately 10 days. We found decreased exogenous insulin requirements and an increase in the NEFA levels with a maximum on the 3rd and 4th day in group II. There were no significant differences in the levels of either albumin, prealbumin or retinol-binding protein, nor were any hepatic or renal alterations related to the xylitol infusion observed. Xylituria was 6.13 +/- 3% of the amount infused. In our opinion, the partial substitution of glucose in group II led to a better utilisation of the infused energy supply, and to less insulin stimulation, which facilitated the mobilization of endogenous energy sources such as fatty acids, although we did not succeed in increasing the protein synthesis.
D000597:Amino Acids, Branched-Chain / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002149:Energy Intake; D004734:Energy Metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005632:Fructose / Q000008:administration & dosage; D005767:Gastrointestinal Diseases / Q000601:surgery; D005950:Glucose Solution, Hypertonic; D006801:Humans; D010289:Parenteral Nutrition, Total; D011183:Postoperative Complications / Q000378:metabolism*; D012177:Retinol-Binding Proteins / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism*; D014993:Xylitol / Q000008:administration & dosage
D000597:Amino Acids, Branched-Chain; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D005950:Glucose Solution, Hypertonic; D012177:Retinol-Binding Proteins; D012709:Serum Albumin; D005632:Fructose; D014993:Xylitol