title: Lipid droplet accumulation in the heart during fasting.
abstract: Lipid droplet accumulation (LDA) in the myocardium in the different regions of the mouse heart was studied after varying periods of starvation. LDA appeared as early as 6 h and remained even after 72 h of starvation. Higher grades of LDA were seen in the left atrium and right ventricle. Females showed a higher degree of infiltration than males. The possible causes for the distribution of lipid droplets are discussed and it is suggested that in long-term starvation reduced oxidation of fatty acids due to mitochondrial inhibition may be a factor in the production of LDA.
mesh_terms: D000818:Animals; D005215:Fasting; D005260:Female; D050356:Lipid Metabolism; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D012737:Sex Factors