Effect of diuretics on ketamine and sulfanilate elimination in cats.
Rate constants of elimination were used to evaluate potential effects of diuretic agents on the elimination of ketamine from the blood of cats. Furosemide, mannitol, and aminophylline did not significantly alter the ketamine elimination rate constants, although the diuretics had a tendency to prolong elimination. This tendency of furosemide was further substantiated by observing the effect of furosemide on glomerular filtration. The rate of sulfanilate elimination, used as an indicator of glomerular filtration, was significantly decreased in the cats that were administered furosemide. Possible mechanisms for the influence of furosemide on the renal excretion of ketamine are discussed.
D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D001557:Benzenesulfonates / Q000493:pharmacokinetics*; D002415:Cats / Q000378:metabolism*; D004232:Diuretics / Q000494:pharmacology*; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D006207:Half-Life; D007649:Ketamine / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D013425:Sulfanilic Acids / Q000493:pharmacokinetics* / Q000494:pharmacology
D001557:Benzenesulfonates; D004232:Diuretics; D013425:Sulfanilic Acids; D000628:Aminophylline; D008353:Mannitol; C100016:4-sulfanilic acid; D007649:Ketamine; D005665:Furosemide