title: Effect of certain chelating agents on the antibacterial action of silver nitrate.
abstract: EDTA and EGTA when used in conjunction with AgNO3 enhanced the antibacterial action of the latter significantly, so that strains of Klebsiella pneumoniae and Staphylococcus aureus resistant to 70 micrograms/ml of AgNO3 were observed to became sensitive to 10 micrograms/ml of this compound. The synergistic effect of EDTA appears to be due to a mechanism other than the removal of lipopolysaccharide from outer membrane, as its effect could be observed in even non-LPS containing gram positive S. aureus cells. Penicillamine, another potent chelator had an opposite effect so that it decreased the toxicity of silver ions.
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002614:Chelating Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D004492:Edetic Acid / Q000008:administration & dosage / Q000494:pharmacology; D004533:Egtazic Acid / Q000008:administration & dosage / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000187:drug effects; D010396:Penicillamine / Q000008:administration & dosage / Q000494:pharmacology; D012835:Silver Nitrate / Q000008:administration & dosage / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D002614:Chelating Agents; D004533:Egtazic Acid; D012835:Silver Nitrate; D004492:Edetic Acid; D010396:Penicillamine