Epithelioid hemangioendothelioma of the liver: report of two cases.
This report describes two patients with hepatic epithelioid hemangioendothelioma: a 33-year-old woman and a 28-year-old man. The first case presented with a palpable abdominal mass and has survived without treatment for 6 years since diagnosis, with ascites but a good general condition. The other patient presented with abdominal pain and cholestasis. He had a rapid course and death occurred 6 months after the onset of symptoms. Histologically the tumors consisted of a proliferation of neoplastic cells with an angiogenic tendency embedded in a myxohyaline stroma. Positivity for the factor VIII-related antigen, for UEA-I and for vimentin and negativity for keratin of the neoplastic cells in the immunohistochemical investigation permitted identification of their endothelial origin. In both cases, the initial diagnosis was erroneous.
D000328:Adult; D000941:Antigens / Q000032:analysis; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D005260:Female; D006390:Hemangioendothelioma / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D037102:Lectins; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism; D008297:Male; D037121:Plant Lectins; D014746:Vimentin / Q000378:metabolism; D014841:von Willebrand Factor
D000941:Antigens; D037102:Lectins; D037121:Plant Lectins; C036850:Ulex europaeus lectins; D014746:Vimentin; D014841:von Willebrand Factor; D005169:Factor VIII