[Experimental study of the fibrosarcoma (S1509a) widely resected by CO2 laser--local recurrence and anti-tumor immunity].
Sarcoma 1509a cells (1 X 10(6] were inoculated into the right dorsum of A/Jackson mice. Laser or surgical resection was performed on the 8th or 11th day after tumor inoculation. Twenty days later, the same number of S1509a was inoculated into the contralateral side of the primary tumor. The local recurrence rate of the tumor resected by the laser was lower than that with the surgical method. Fewer mice rejected the reinoculated tumor after resection using laser method than after surgical resection. A/Jackson mice, hyperimmuned with S1509a, were inoculated with 3 X 10(6) cells of the S1509a on the 2nd, 5th, 10th and 21st days after laser irradiation. Hyperimmunized mice inoculated with the sarcoma cells on the 2nd day after laser irradiation showed higher acceptability of the tumor than immune mice without irradiation. However, other groups of mice rejected the inoculated sarcoma cells. These results suggest that suppression of tumor specific immunity was induced by laser irradiation.
D000818:Animals; D002245:Carbon Dioxide; D005354:Fibrosarcoma / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D007108:Immune Tolerance / Q000528:radiation effects*; D053685:Laser Therapy; D051379:Mice; D008815:Mice, Inbred Strains; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000276:immunology / Q000473:pathology / Q000601:surgery*
D002245:Carbon Dioxide