[Experimental and clinical studies on degradable starch microspheres (DSM) in the treatment of hepatic neoplasms].
To evaluate the effect of hepatic arterial chemotherapy combined with DSM, experimental and clinical studies were performed. Experimental study: Hemodynamic and histological changes induced by intra-arterial administration of DSM were investigated in the kidneys of rabbits. The degree of blockade of arterial blood flow was correlated with the dosage of DSM, and estimated by the angiographic change. Histological changes also depended on the dosage of DSM. Although administration of less than 6 mg DSM induced little or no histological changes, more than 15 mg of DSM induced extensive necrosis of renal tubules. Clinical study: The hepatic arterial chemotherapy combined with DSM was performed in 63 patients (hepatomas in 45 and metastatic tumors in 18). Fourteen patients (30%) showed partial or complete response. Patients with a higher degree of blockade of arterial blood flow tended to have a better response. Analysis of CT images suggested that DSM not only enhance the chemotherapeutic agents but also the ischemic effect. In conclusion, degree of blockade of arterial blood flow is controlled by the change in DSM dosage, and DSM administration combined with chemotherapeutic agents may have the potential to improve the therapeutic effect.
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage; D004621:Embolization, Therapeutic / Q000379:methods; D006439:Hemodynamics; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D011817:Rabbits; D012074:Remission Induction; D012077:Renal Artery; D012079:Renal Circulation; D013213:Starch / Q000008:administration & dosage* / Q000494:pharmacology
D008937:Mitomycins; D016685:Mitomycin; D004317:Doxorubicin; D013213:Starch