Role of membrane-bound haemoglobin products in oxidative damage in sickle cell membranes.
Even though the development of the membrane abnormalities in sickle cell erythrocytes is due to the presence of a mutant gene product, sickle cell anaemia is in a sense a membrane disease. In particular, the presence of iron-containing breakdown products of haemoglobin in the sickle cell membranes provides a source of continued oxidative damage. An understanding of the primary causes of these membrane abnormalities may be useful in the development of effective therapies.
D000755:Anemia, Sickle Cell / Q000097:blood*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D010084:Oxidation-Reduction; D012016:Reference Values; D012805:Sickle Cell Trait / Q000097:blood*
D006454:Hemoglobins; D008054:Lipid Peroxides; D007501:Iron