title: [A valproic acid-diazepam combination as an alternative to neuroleptic treatment].
abstract: Thirty years after their introduction neuroleptics experience a high rate of failure and intolerance in long-standing serious cases. The contra-indications are concentrated in hospital services due to their associated organic pathology. The clinician is often at a loss in these cases. Benzodiazepines on their own are often insufficient, but well tolerated. Sodium Valproate, aside from its anti-comitial activity, has already proven to be active in the treatment and the prevention of manic episode. Pharmaco-kinetic and pharmaco-dynamic arguments favour a synergic action for Sodium Valproate and Diazepam. This association has been prescribed in fourteen cases of failure, intolerance or contra-indication of neuroleptics in chronic psychotics. Tolerance has been perfect and eight good stable results have been obtained. This association merits study and test in the conditions described.
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000188:drug therapy; D003975:Diazepam / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000188:drug therapy*; D012559:Schizophrenia / Q000188:drug therapy; D014635:Valproic Acid / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D014635:Valproic Acid; D003975:Diazepam
vernacular_title: L'association acide valproïque-Diazepam (1) comme alternative au traitement neuroleptique.