[Biological effects of particle radiation].
Conventional radiations such as photons, gamma rays or electrons show several physical or biological disadvantages to bring tumors to cure, therefore, more and more attentions is being paid to new modality such as fast neurons, protons, negative pions and heavy ions, which are expected to overcome some of the defects of the conventional radiations. Except for fast neutrons, these particle radiations show excellent physical dose localization in tissue, moreover, in terms of biological effects, they demonstrate several features compared to conventional radiations, namely low oxygen enhancement ratio, high value of relative biological effectiveness, smaller cellular recovery, larger therapeutic gain factor and less cell cycle dependency in radiation sensitivity. In present paper the biological effects of particle radiations are shown comparing to the effect of conventional radiations.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects*; D006224:Cricetinae; D004307:Dose-Response Relationship, Radiation; D006168:Guinea Pigs; D009374:Neoplasms, Experimental / Q000473:pathology / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D012867:Skin / Q000528:radiation effects; D014407:Tumor Cells, Cultured / Q000528:radiation effects