Transfer of granulomatous inflammation with nonviable preparations of schistosome granulomas in naive mice.
Hepatic granulomas of euthymic (nu/+) mice infected with Schistosoma mansoni were freeze-dried or freeze-thawed 3 times and transplanted subcutaneously into naive nu/+ and athymic (nu/nu) mice. The grafted sites, studied histologically, showed formation of organized granulomas in nu/+ mice similar to donor granulomas as observed after grafting of freshly isolated granulomas. On the other hand, in nu/nu mice, the nonviable transplants elicited small and disorganized granulomas, like hepatic granulomas in nu/nu mice with schistosomiasis, but different from fresh nu/+ transplants in nu/nu skin. The findings indicate viable cells are not required for transfer of granulomatous reactions, but T cells are needed for full expression.
D000818:Animals; D006099:Granuloma / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D007116:Immunization, Passive; D007249:Inflammation / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000469:parasitology* / Q000473:pathology; D012867:Skin / Q000276:immunology / Q000469:parasitology / Q000473:pathology