Ethanol and chlordiazepoxide cross-dependence.
Cross-dependence between ethanol and chlordiazepoxide (CDP) was demonstrated by a bidirectional experiment involving induction of ethanol dependence in mice by a liquid diet method followed by substitution of ethanol with CDP. The administration of CDP diets fully suppressed ethanol withdrawal signs. After a period (14-24 days) of CDP administration the mice showed spontaneous CDP withdrawal signs following the termination of CDP diet. Similar signs, but much more short-lived, can also be precipitated by injection of the benzodiazepine receptor antagonist, RO-15-788.
D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D002707:Chlordiazepoxide; D005442:Flumazenil / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology; D019966:Substance-Related Disorders / Q000503:physiopathology*
D005442:Flumazenil; D002707:Chlordiazepoxide