Influence of some inhibitors and activators of fibrinolysis on transcapillary transport of macromolecules.
The RISA transcapillary transport in the posterior paw was followed up under the influence of some substances inhibiting and activating fibrinolysis (Trasylol, EACA and Streptokinase and Salyrgan, respectively) in 11 dogs under narcosis with chloralose and the cannulation of the lymphatics in the popliteal space. It was found that EACA inhibits the transcapillary RISA transport and streptokinase activates it. Trasylol and Salyrgan produced no changes, the slope of the vanishing curve of the tracer being identical with that of the controls.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D004285:Dogs; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D008196:Lymph / Q000378:metabolism; D008297:Male; D012711:Serum Albumin, Radio-Iodinated / Q000097:blood / Q000493:pharmacokinetics*
D005343:Fibrinolytic Agents; D012711:Serum Albumin, Radio-Iodinated