Single-dose piperacillin versus cefoxitin combined with 10 percent mannitol bowel preparation as prophylaxis in elective colorectal operations.
A prospective, randomized study was utilized to compare the effectiveness of a single dose of preoperative piperacillin versus triple-dose cefoxitin in prophylaxis for elective colorectal operations. All patients received a simple 1 day mechanical bowel preparation using 10 percent mannitol preparation administered orally. Ninety-four patients were entered into the study. Septic complications occurred in 9 percent of the piperacillin patients and in 12 percent of the cefoxitin patients.
D002400:Cathartics; D002440:Cefoxitin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003106:Colon / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008353:Mannitol / Q000627:therapeutic use*; D008875:Middle Aged; D010878:Piperacillin / Q000627:therapeutic use*; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D012007:Rectum / Q000601:surgery*; D013530:Surgical Wound Infection / Q000517:prevention & control*
D002400:Cathartics; D008353:Mannitol; D002440:Cefoxitin; D010878:Piperacillin