Total parental nutrition using conventional and medium chain triglycerides: effect on liver function tests, complement, and nitrogen balance.
Conventional long chain triglyceride (LCT) was compared with a new emulsion containing 50% medium chain triglyceride (5% MCT/5% LCT) in a randomized cross-over trial of 10 days duration. Plasma concentrations of albumin, prealbumin, the complement components C3 and C4, and prothrombin times measured daily at 8 am, before lipid infusion, showed no progressive change during the 10 days of the trial, nor in each separate 5-day period when LCT or MCT/LCT was infused. Aspartate transaminase and alkaline phosphatase activities were similar over the two periods. There was a significant increase (compared with preinfusion levels) in C3 and C4 levels after 5 hr of either lipid infusion. Nitrogen balance was improved, and plasma bilirubin levels were lower on the regimen containing MCT/LCT.
D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000097:blood; D003176:Complement C3 / Q000032:analysis*; D003181:Complement C4 / Q000032:analysis*; D004338:Drug Combinations / Q000494:pharmacology; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005990:Glycerol / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009584:Nitrogen / Q000378:metabolism*; D010289:Parenteral Nutrition, Total / Q000379:methods*; D010743:Phospholipids / Q000494:pharmacology; D011446:Prospective Studies; D013024:Soybean Oil / Q000494:pharmacology; D014280:Triglycerides / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*
D003176:Complement C3; D003181:Complement C4; D004338:Drug Combinations; D005217:Fat Emulsions, Intravenous; D010743:Phospholipids; D014280:Triglycerides; C046535:Lipofundin S; D013024:Soybean Oil; D009584:Nitrogen; D005990:Glycerol; D001663:Bilirubin