[Experimental study of the antiepileptic activity of fenibut and its combinations with sodium valproate and aminooxyacetic acid].
The antiepileptic activity of GABA-mimetics (phenibut, sodium valproate and aminooxyacetic acid/AOAA/) was studied in experiments on the model of hippocampal penicillin-induced epilepsy in rats. The effects of the drugs were studied in experiments with a mirror epileptogenic focus which forms in the hippocampus contralateral to the penicillin-damaged hippocampus. All the drugs suppressed the activity of the epileptogenic focus after injections in the focus region. At systemic administration of the drugs the antiepileptic activity was found only with sodium valproate and AOAA. Phenibut enhanced the antiepileptic effect of sodium valproate and the toxic effects of AOAA at parenteral administration.
D000085:Acetates / Q000627:therapeutic use*; D000625:Aminooxyacetic Acid / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D010406:Penicillins; D051381:Rats; D014635:Valproic Acid / Q000627:therapeutic use* / Q000633:toxicity; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity
D000085:Acetates; D000927:Anticonvulsants; D010406:Penicillins; D000625:Aminooxyacetic Acid; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; C008842:4-amino-3-phenylbutyric acid
Eksperimental'noe izuchenie protivoépileticheskoĭ aktivnosti fenibuta i ego kombinatsiĭ s val'proatom natriia i aminooksiuksusnoĭ kislotoĭ.