[Effect of cyclosporin A on blood pressure and renal hemodynamics in insulin dependent diabetes].
In 13 patients with very recent onset insulin-dependent diabetes (IDD) (less than 3 months) we studied arterial pressure and renal hemodynamics before (M0) and after 3 months (M3) of treatment with cyclosporine A (5 mg/kg/d). Glomerular filtration rate (GFR) and effective renal plasma flow (RPF) were measured by inulin and PAH clearance respectively. Results, expressed as mean +/- SD were compared to those obtained in 8 healthy controls (C). At M0, GFR and filtration fraction were 143 +/- 21 ml/mn.1.73 m2 and 0.22 +/- 0.04 respectively and significantly increased as compared to control values. After 3 months of chronic cyclosporine administration, mean arterial pressure (MAP) significantly increased from 84.7 to 91.8 mmHg whereas GFR and FF significantly decreased to 114 +/- 23 ml/mn.1.73 m2 and 0.18 +/- 0.01 respectively. Renal vascular resistance (RVR) showed a trend toward increase from 658 +/- 161 to 728 +/- 225 MPa.s/L.1.73 m2 whereas natriuresis was unchanged. We concluded: 1) Cyclosporine A significantly increased MAP in patients with IDD; 2) Cyclosporine-induced increase in MAP may be in part related to rise in RVR; 3) In spite of the decrease in GFR, cyclosporine did not seem to induce persistent antinatriuretic effect.
D001794:Blood Pressure / Q000187:drug effects*; D003524:Cyclosporins / Q000009:adverse effects / Q000494:pharmacology*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000098:blood supply*; D012079:Renal Circulation / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D003524:Cyclosporins
Effet de la ciclosporine A sur la pression artérielle et l'hémodynamique rénale au cours du diabète insulinodépendant.