Lymphotoxin-induced growth stimulation of diploid human fibroblasts in the presence and absence of gamma interferon.
In the present study we investigated the effect of lymphotoxin (LT) on the growth of human diploid fibroblasts, in the presence and absence of gamma interferon (IFN-gamma). Recombinant LT (rLT) had a growth stimulatory effect on diploid human FS-4 fibroblasts. This growth-stimulatory effect was reduced in the presence of recombinant IFN-gamma (rIFN-gamma). LT thus has a similar effect on diploid fibroblasts as tumour necrosis factor (TNF).
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008233:Lymphotoxin-alpha / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D008233:Lymphotoxin-alpha; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma