Blood-membrane interactions during haemodialysis with cellulose and synthetic membranes.
Haemodialysis is associated with transient leucopenia, hypoxia and activation of the patient's complement system, mediated by blood-membrane contact. Changes in white blood cell counts, blood gases (PaO2 and PaCO2), carbon monoxide diffusing capacity (DLCO) and complement activation (C3d and C3a) were measured pre-treatment and during dialysis. The degree of complement activation, leucopenia and changes in DLCO were influenced by membrane type; these changes were most marked for cellulosic membranes and were much reduced for synthetic membranes. A significant relationship between the degree of leucopenia and the magnitude of change in DLCO during dialysis was demonstrated.
D000180:Acrylic Resins; D001672:Biocompatible Materials; D001769:Blood; D002245:Carbon Dioxide / Q000097:blood; D002248:Carbon Monoxide / Q000097:blood; D002482:Cellulose / Q000031:analogs & derivatives; D003167:Complement Activation; D003176:Complement C3 / Q000378:metabolism; D015933:Complement C3d; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D007700:Kinetics; D007970:Leukopenia / Q000209:etiology; D008567:Membranes, Artificial; D010100:Oxygen / Q000097:blood; D011108:Polymers; D006435:Renal Dialysis / Q000009:adverse effects*; D013450:Sulfones
D000180:Acrylic Resins; D001672:Biocompatible Materials; D003176:Complement C3; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C054645:Hemophan; D002245:Carbon Dioxide; C010504:polyacrylonitrile; C017662:polysulfone P 1700; C049723:polycarbonate-polyether copolymer; D002248:Carbon Monoxide; D015933:Complement C3d; D002482:Cellulose; C009865:cuprammonium cellulose; D010100:Oxygen