Chromium chloride induces chromosomal aberrations in human lymphocytes via indirect action.
The aim of this study was to examine the possible clastogenic effects of trivalent chromium chloride (CrCl3) as the results in the literature are non-conclusive. Under the conditions used in this study Cr(III) induces chromosomal aberrations in phytohemagglutinin(PHA)-stimulated human lymphocytes. This activity, however, is suppressed by the antioxidants superoxide dismutase (SOD) (scavenger of O-.2), the SOD-like agents, catalase and mannitol (specific scavenger of OH.). The possibility that oxygen free radicals could evolve through stimulation of the arachidonic acid cascade is suggested using suitable inhibitors.
D015117:5,8,11,14-Eicosatetraynoic Acid / Q000494:pharmacology; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000502:physiology; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D002712:Chlorides; D002857:Chromium / Q000633:toxicity*; D017608:Chromium Compounds; D002869:Chromosome Aberrations; D005609:Free Radicals; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects; D009637:Masoprocol / Q000494:pharmacology; D010100:Oxygen
D001095:Arachidonic Acids; D002712:Chlorides; D017608:Chromium Compounds; D005609:Free Radicals; D002857:Chromium; D015117:5,8,11,14-Eicosatetraynoic Acid; D016718:Arachidonic Acid; D009637:Masoprocol; C017133:chromous chloride; D010100:Oxygen; D007213:Indomethacin