title: Initial experience with 99m Tc-hexamethyl-propylene amine oxime (HM-PAO) single photon emission computed tomography (SPECT) in patients with focal epilepsy.
abstract: Brain single photon emission computed tomography (SPECT) was performed in 16 patients with focal epilepsy, as well as EEG, using 99m Tc-HM-PAO SPECT and a rotating gamma camera system. Pathological Tc-HM-PAO SPECT findings were registered in 75%. CT was positive in 25%. MRI was positive in 76%. The results of Tc-HM-PAO SPECT findings were compared with those of CT and MRI. 61% of the MRI findings correlated with the pathological SPECT findings with respect to the side of the hemisphere, and in 75% of the patients the focal EEG abnormality and the pathological Tc-HM-PAO-SPECT findings were localized in the same hemisphere.
mesh_terms: D000293:Adolescent; D000328:Adult; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed / Q000379:methods*; D014057:Tomography, X-Ray Computed
chemical_list: D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime