Evaluation of the Ca 1 monoclonal antibody in distinguishing oral squamous cell carcinoma from non-malignant or premalignant oral lesions.
The Ca antigen has been reported to be present on the surface of malignant but not, with few exceptions, non-malignant cells. We investigated the potential usefulness of the monoclonal Ca 1 antibody in differentiating oral squamous cell carcinoma from non-malignant or premalignant oral neoplasms. Paraffin-embedded sections from 33 biopsy specimens of 12 hyperplastic and 21 neoplastic oral lesions were examined by immunohistochemical staining. Seven of the 33 specimens showed positive staining for Ca antigen. Fifteen of 21 specimens of oral squamous cell carcinoma were negative for Ca antigen, and one case of focal keratosis was positive. The results indicate that the use of the Ca 1 antibody to distinguish oral squamous cell carcinoma from non-malignant or premalignant oral lesions is highly unreliable.
D000906:Antibodies / Q000032:analysis*; D000912:Antibodies, Neoplasm / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D009059:Mouth Diseases / Q000175:diagnosis / Q000276:immunology*; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000276:immunology*; D011230:Precancerous Conditions / Q000175:diagnosis / Q000276:immunology*
D000906:Antibodies; D000912:Antibodies, Neoplasm; C038104:Ca1 antibody