Inactivation of HIV in plasma derivatives by beta-propiolactone and UV irradiation.
The inactivation of HIV in human plasma and plasma derivatives by combined treatment with beta-propiolactone and UV-irradiation was investigated. beta-propiolactone inactivated greater than or equal to 3.5 log10 and UV greater than or equal to 2.8 log10 HIV in plasma and beta-propiolactone greater than or equal to 3.5 log10 in cryoprecipitate and UV irradiation greater than or equal to 4.5 log10 in factor VIII concentrate.
D004340:Drug Contamination; D005169:Factor VIII; D005340:Fibrinogen; D005353:Fibronectins; D006678:HIV / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D006801:Humans; D010949:Plasma / Q000382:microbiology*; D011420:Propiolactone / Q000494:pharmacology; D014466:Ultraviolet Rays
D005353:Fibronectins; C026912:cryoprecipitate coagulum; D011420:Propiolactone; D005169:Factor VIII; D005340:Fibrinogen