title: [Clinical efficacy of a Minidiab preparation (glipizide) in an acute experiment].
abstract: The hypoglycemic action of Minidiab (Glipizide) and maninil (Glibenclamide) were studied in an acute experiment. 10 patients with type 2 diabetes mellitus (6 men and 4 women, mean age 49.1 years, were examined. The blood sugar level and the insulinemia were followed up after a 10 mg morning dose of each drug. The hypoglycemic action of both drugs is identical but is reached in different ways. Minidiab has a faster, shorter but stronger insulinotropic action. Maninil exerts a better peripheral effect.
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy; D004341:Drug Evaluation; D005260:Female; D005913:Glipizide / Q000627:therapeutic use*; D005905:Glyburide / Q000627:therapeutic use; D006801:Humans; D007330:Insulin Antibodies / Q000032:analysis; D008297:Male; D008875:Middle Aged; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007330:Insulin Antibodies; D013453:Sulfonylurea Compounds; D005905:Glyburide; D005913:Glipizide
vernacular_title: Prouchvane na klinichnata efektivnost na preparata Minidiab (glipizide) v ostŭr opit.