Lipid metabolism in rat models of causes of hyperinsulinaemia in insulin treated man.
Experience with rat models of potential causes of hyperinsulinaemia in insulin-treated diabetic man are compared. Peripheral insulin delivery from transplanted islets failed to disturb lipid metabolism, probably because no disturbance of glucose tolerance, glucose metabolism, or peripheral insulin levels was detectable. Overtreatment of normal rats with insulin induced abnormalities of VLDL-triglyceride production and clearance, and of skeletal muscle lipoprotein lipase. Periods of overinsulinisation are common in diabetic patients intensively treated with insulin, and may give rise to abnormalities of lipid metabolism.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000627:therapeutic use; D016381:Islets of Langerhans Transplantation; D050356:Lipid Metabolism; D008071:Lipoprotein Lipase / Q000378:metabolism; D008079:Lipoproteins, VLDL / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D007328:Insulin; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol; D008071:Lipoprotein Lipase