Treatment of experimental intravitreal fibrin with tissue plasminogen activator.
We produced experimental intravitreal fibrin clots in rabbits that had previous gas compression of the vitreous or intact vitreous. Twenty-four hours after production of fibrin, the eyes were injected with 25 micrograms of tissue plasminogen activator or physiologic irrigation solution. In the gas compression group (n = 11), all tissue plasminogen activator-treated eyes cleared within six hours of injection; complete clearing was not seen until six days in the physiologic irrigation solution-treated eyes (n = 9). A similar response was seen in the intact vitreous group. No evidence of toxicity was observed as measured by slit-lamp biomicroscopy, intraocular pressure, corneal thickness, electroretinography, or histopathologic examination.
D000818:Animals; D003315:Cornea / Q000033:anatomy & histology; D004596:Electroretinography; D005337:Fibrin / Q000378:metabolism*; D007429:Intraocular Pressure / Q000187:drug effects; D011817:Rabbits; D010959:Tissue Plasminogen Activator / Q000494:pharmacology*; D014822:Vitreous Body / Q000378:metabolism*
D005337:Fibrin; D010959:Tissue Plasminogen Activator