Codon preference reflects mistranslational constraints: a proposal.
Following the observation of lysine for arginine misincorporation at the poor choice codon arg-AGA, a comparison of codon usage patterns for highly expressed mRNA's in E. coli provides a basis for the proposal that the major codon preference is subject to mistranslational constraints. In addition, the codons are utilized, as well as arranged, to provide a hydropathically conservative amino acid as the most probable replacement resulting from a mistranslational event.
D001120:Arginine; D001482:Base Composition; D003062:Codon; D004926:Escherichia coli / Q000235:genetics; D008239:Lysine; D014176:Protein Biosynthesis; D012333:RNA, Messenger
D003062:Codon; D012333:RNA, Messenger; D001120:Arginine; D008239:Lysine