[Control of growth hormone release by growth hormone-releasing factor and prostaglandin E2 in a system of perfused rat anterior pituitary cells].
Using superfused rat pituitary cells we showed that the growth hormone-releasing factor (GRF) and prostaglandin E2 (PGE2) increased growth hormone (GH) secretion in a similar manner in terms of kinetics and amplitude of responses. Moreover, our data suggest that they stimulate GH secretion mainly by cAMP-dependent mechanisms.
D000818:Animals; D002478:Cells, Cultured; D015232:Dinoprostone; D013006:Growth Hormone / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D008297:Male; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats
D011458:Prostaglandins E; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D015232:Dinoprostone
Contrôle de la libération de la GH par le GRF et la prostaglandine E2 dans un système de périfusion de cellules anté-hypophysaires de rat.