Elastic properties of the excised lungs of NZB/W mice and their correlation with histopathologic changes.
Lung volume and the pressure-volume (PV) relationships of the lung were determined in excised lungs of an animal model of human systemic lupus erythematosus, which develops in NZB/W mice, and correlated with histopathologic changes. In young, 4-month-old NZB/W mice, and in nonautoimmune BALB/c mice at any age, there were minimal histologic changes or alterations in lung function. The NZB/W mice developed histologic changes with aging. Perivascular, peribronchial, and interstitial changes developed and were associated with a significant reduction in total lung capacity as well as changes in the pressure-volume characteristics of the lung, which are compatible with a restrictive process.
D000367:Age Factors; D000818:Animals; D004548:Elasticity; D066298:In Vitro Techniques; D008168:Lung / Q000473:pathology / Q000503:physiopathology*; D008171:Lung Diseases / Q000473:pathology / Q000503:physiopathology*; D008176:Lung Volume Measurements; D008180:Lupus Erythematosus, Systemic / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008814:Mice, Inbred NZB; D012119:Respiration