Protection by GABA agonists, gamma-hydroxybutyric acid, and valproic acid against seizures evoked in epileptic chicks by hyperthermia.
With microwave diathermy, febrile seizures were produced in epileptic chicks aged 2-5 days. Drugs that enhance GABAergic activity (i.e., GABA, muscimol, and progabide), as well as valproic acid and gamma-hydroxybutyric acid, produced dose-dependent increases in latency to onset of seizures.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002645:Chickens; D005334:Fever / Q000150:complications; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D006979:Hyperthermia, Induced; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D012978:Sodium Oxybate / Q000627:therapeutic use*; D014635:Valproic Acid / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D006885:Hydroxybutyrates; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D012978:Sodium Oxybate