title: [Psychotropic properties of nootropic substances with a cholinergic action component in single and long-term use].
abstract: Long-term administration of centrophenoxine and cleregil was found to exert on rats the antiamnestic and anxiogenic-like effects, to increase emotional reactivity and aggressiveness, to reduce motor activity and readiness to contact. The withdrawal of centrophenoxine and especially cleregil was followed by still greater enhancement of emotional reactivity and the appearance of spontaneous aggressiveness.
mesh_terms: D000374:Aggression / Q000187:drug effects; D000647:Amnesia / Q000188:drug therapy; D000818:Animals; D003642:Deanol; D004338:Drug Combinations / Q000008:administration & dosage / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004644:Emotions / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D005971:Glutamates / Q000008:administration & dosage / Q000494:pharmacology*; D006016:Glycolates / Q000494:pharmacology*; D008297:Male; D002504:Meclofenoxate / Q000008:administration & dosage / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D005971:Glutamates; D006016:Glycolates; D011619:Psychotropic Drugs; D003642:Deanol; C043253:deanol aceglutamate; D002504:Meclofenoxate
vernacular_title: Psikhotropnye svoĭstva nootropnykh veshchestv s kholinergicheskim komponentom deĭstviia pri odnokratnom i dlitel'nom primenenii.