[Characteristics of the conditioned reaction of passive avoidance in rats after destruction of the terminal dopaminergic fields in the amygdaloid complex].
Character of conditioned reaction of passive avoidance was analyzed in Wistar line male rats after neurochemical destruction of terminal dopaminergic fields of the amygdalar complex. 6-hydroxydopamine was bilaterally administered to the central nucleus of the amygdalar complex after preliminary treating with desmethylimipramine for selective destruction of dopaminergic terminals. Lowering of dopamine level in the amygdalar complex led to a weakening of reproduction and to prolongation of spontaneous extinction of conditioned reaction. Features of conditioned reaction are highly similar to the effect of latent inhibition connected with attention deficit. It is suggested that activity of terminal fields of the amygdalar complex is one of the mechanisms providing for attention and intensifying selection of information in learning.
D000679:Amygdala / Q000032:analysis / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D002395:Catecholamines / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D006892:Hydroxydopamines / Q000633:toxicity; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*
D002395:Catecholamines; D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D016627:Oxidopamine
Osobennosti uslovnoĭ reaktsii passivnogo izbeganiia u krys posle razrusheniia terminal'nykh dofaminergicheskikh poleĭ v mindalevidnom komplekse.