title: Alpha-thalassaemia and the malaria hypothesis.
abstract: Recent population genetic studies of the distribution of alpha+-thalassaemia in Melanesia using DNA analysis have provided strong support for the hypothesis that high frequencies of this genetic disorder are the result of natural selection by malaria.
mesh_terms: D000367:Age Factors; D000818:Animals; D001927:Brain Diseases / Q000150:complications; D004912:Erythrocytes / Q000469:parasitology; D005838:Genotype; D005914:Globins / Q000235:genetics; D006801:Humans; D008288:Malaria / Q000150:complications / Q000453:epidemiology / Q000235:genetics* / Q000469:parasitology / Q000503:physiopathology; D008542:Melanesia; D008957:Models, Genetic; D010961:Plasmodium / Q000302:isolation & purification; D012641:Selection, Genetic; D013789:Thalassemia / Q000097:blood / Q000150:complications / Q000453:epidemiology*
chemical_list: D005914:Globins