title: Purine nucleoside phosphorylase heterogeneity in the mouse as analyzed by isoelectric focusing and specific activity.
abstract: 1. Isoelectric focusing in polyacrylamide gels identified three erythrocytic electrophoretic patterns of purine nucleoside phosphorylase in a survey of 16 mouse strains. 2. Three strain-specific electrophoretic types were also evident in liver, kidney and spleen leukocytes. 3. There are 3-fold differences in purine nucleoside phosphorylase activities between strains for several tissues; C57BL/6J and Mus spretus having the greatest and the least activity, respectively. 4. Within strains there were up to 8-fold tissue-specific differences in activity with the order from greatest to least being: liver, kidney, spleen leukocyte, erythrocyte, heart.
mesh_terms: D000818:Animals; D007525:Isoelectric Focusing; D007700:Kinetics; D051379:Mice; D008810:Mice, Inbred C57BL; D010430:Pentosyltransferases / Q000032:analysis*; D011683:Purine-Nucleoside Phosphorylase / Q000032:analysis*; D012016:Reference Values; D013045:Species Specificity
chemical_list: D010430:Pentosyltransferases; D011683:Purine-Nucleoside Phosphorylase