Effect of neurotoxic lesions in the mammillary bodies on the distribution of brain histamine.
Unilateral lesions with ibotenic acid in the vicinity of the mammillary bodies where the histamine (HA)-secreting neurons are located induced bilateral reductions in the levels of HA in the posterior hypothalamus (40-60%), anterior hypothalamus (45%), and frontal cortex (30%) as well as in the ipsilateral hippocampus (40%) 7 days after injection. Changes in the concentration of HA in the median eminence and adenohypophysis were not significant, but in the neurohypophysis the content of HA increased by 80%. These results seem to indicate that intrahypothalamic and cortical HA pathways are bilateral in origin while hippocampal HA pathways are predominantly ipsilateral.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005625:Frontal Lobe / Q000378:metabolism; D007839:Functional Laterality / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism; D006632:Histamine / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D007051:Ibotenic Acid; D008297:Male; D008326:Mammillary Bodies / Q000187:drug effects / Q000378:metabolism*; D009434:Neural Pathways / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D007051:Ibotenic Acid; D006632:Histamine