DNA ploidy in 1,2-dimethylhydrazine-induced rat tumors.
The DNA content of 1,2-dimethylhydrazine (DMH)-induced intestinal tumors of male Wistar rats was analyzed by using flow cytometry. All adenomas and carcinomas were DNA diploid. S-phase fractions of tumors showed no significant difference from those of normal mucosae. Histological evidence of adenoma-carcinoma sequence was observed in our series. The lack of DNA aneuploidy is one of the principal differences between the DMH model and human colorectal cancers.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D004247:DNA / Q000032:analysis*; D004127:Dimethylhydrazines; D005434:Flow Cytometry; D007414:Intestinal Neoplasms / Q000139:chemically induced*; D008297:Male; D008763:Methylhydrazines; D011003:Ploidies; D051381:Rats; D011919:Rats, Inbred Strains
D004127:Dimethylhydrazines; D008763:Methylhydrazines; D004247:DNA; D019813:1,2-Dimethylhydrazine