title: Dissociated response of plasma albumin and transferrin to protein-calorie restriction in squirrel monkeys (Saimiri sciureus).
abstract: The responses of albumin and transferrin to selective nutritional interventions were assessed in 31 infant monkeys. Diets were restricted in protein, calories, or both from age 2 to 8 wk (study A) or protein alone from age 4 to 24 wk (study B)--in both cases to prevent growth. Transferrin levels in study A were significantly lower than control in all three restricted groups whereas albumin levels were decreased only in both low-protein groups. In study B albumin and transferrin concentrations were significantly decreased during the first 12 wk of intervention. A sharp recovery in the transferrin concentrations, however, was observed when a minimal increase in protein intake was allowed in the latter portion of the study. It appears that the response of albumin is linked to amino acid availability whereas the response of transferrin is influenced by variables such as acute dietary manipulation and rate of growth, among others. The value of these indices as single predictors of nutritional status is questioned.
mesh_terms: D000367:Age Factors; D000818:Animals; D001835:Body Weight; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D005260:Female; D006400:Hematocrit; D008297:Male; D011502:Protein-Energy Malnutrition / Q000097:blood*; D012453:Saimiri; D012709:Serum Albumin / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism*
chemical_list: D004044:Dietary Proteins; D012709:Serum Albumin; D014168:Transferrin