[Transmission of the human immunodeficiency virus by a dry heat-treated Factor VIII concentrate?].
Short presentation of the common procedures to avoid transmission of human-immunodeficiency-virus (HIV) by hemoderivates especially clotting-factor-preparations. The stepwise seroconversion (ELISA, IFT, Western-blot) of HIV is shown in a 7 5/12 ys old boy with hemophilia A after administration of a dry-heated factor VIII-preparation. Seven similar observations were reported in the literature. On the other hand HIV-seroconversion could not be observed during treatment with wet-heated factor VIII-preparations. In consequence only wet-heated factor VIII-preparations and factor IX-preparations respectively should be administered to hemophiliacs without HIV-antibodies. By this precaution transmission of non-A, non-B-hepatitis may be avoided simultaneously.
D000163:Acquired Immunodeficiency Syndrome / Q000635:transmission*; D002648:Child; D003890:Desiccation; D005169:Factor VIII / Q000009:adverse effects* / Q000627:therapeutic use; D006467:Hemophilia A / Q000628:therapy*; D006358:Hot Temperature; D006801:Humans; D008297:Male
D005169:Factor VIII
Ubertragung von Human-Immunodeficiency-Virus (HIV) durch trocken-hitzebehandelte Faktor-VIII-Gerinnungspräparate?