Investigations on the early diagnosis of cystinuria in children.
The procedure described confirms that the Ni2+/S2O4(2-) tablet test is a suitable quick cystine screening test for large groups. In 16 (0.67%) of 2,395 one- to three-year-old crèche children significantly enhanced cystine levels of 0.60-0.96 mmol/l were found. The corresponding creatinine values (mmol/l) did not reveal any significant deviations from the normal values. In a preliminary group of 9 children, enhanced lysine levels support the suspicion of the existence of cystinuria without clinical symptoms. This also forms the basis for further necessary family histories as well as for prophylactic measures.
D002675:Child, Preschool; D003124:Colorimetry; D003404:Creatinine / Q000652:urine; D003555:Cystinuria / Q000235:genetics / Q000517:prevention & control*; D006801:Humans; D007202:Indicators and Reagents; D007223:Infant; D008239:Lysine / Q000652:urine; D008403:Mass Screening / Q000379:methods*
D007202:Indicators and Reagents; D003404:Creatinine; D008239:Lysine