[Effect of folic acid on the activity of monooxygenase system, UDP-glucuronyl- and glutathione-S-transferase in the normal and regenerating rat liver].
After administration into rats of folic acid at a dose of 25 mg/kg within 14 days activities of NADPH-cytochrome P-450 and NADH-cytochrome b5 reductases, content of cytochromes P-450 and b5 as well as the rates of NADPH and NADH oxidation were increased in liver microsomes. The stimulating action of the vitamin was also observed within later periods of liver tissue regeneration during 8 days after partial hepatectomy. Content of cytochrome b5, binding of cytochrome P-450 with aniline, N-demethylation of ethylmorphine as well as activities of UDP-glucuronyl- and glutathione-S-transferases were increased by 23-46% after the treatment as compared with control partially hepatectomized animals. At the period of high mitotic activity of hepatocytes, within 2 days after the operation, the vitamin did not affect the parameters studied.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D005492:Folic Acid / Q000494:pharmacology*; D014453:Glucuronosyltransferase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D006900:Hydroxylation; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D051381:Rats
D003577:Cytochrome P-450 Enzyme System; D005492:Folic Acid; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase
Vliianie folievoĭ kisloty na aktivnost' monooksigenaznoĭ sistemy, UDF-gliukuronil- i glutation-S-transferaz normal'noĭ i regeneriruiushcheĭ pecheni krys.