[Determination of the oxidation rate of medium-chain triglycerides in newborn infants with the 13C trioctanoin breath test].
Up to the present time medium chain triglycerides (MCT) have been applied solely for the enteral nutrition of newborn infants. Results of the oxidative utilization of parenterally applicated MCT have not yet been published. We therefore investigated the MCT oxidation with the 13C trioctanoin breath test in neonates. The patients received parenterally 10 mg/kg MCT (1-13C3 trioctanoin) enriched with the stable isotope 13C and emulsified with MCT/LCT 10%. The expired 13CO2 resulting from fat oxidation was determined by a ratio-mass-spectrometer. The 13C content of exhaled air represents the rate of fatty acid oxidation. Within the test period the fatty acid oxidation showed a clear dependency on the simultaneous carbohydrate supply. The oxidation rates of MCT were about twice als high as those of long chain triglycerides (LCT). On account of their high energetic level, MCT-containing emulsions are, in principle, also suitable for the parenteral nutrition of newborn infants.
D001944:Breath Tests / Q000379:methods*; D002210:Caprylates; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010084:Oxidation-Reduction; D010288:Parenteral Nutrition; D012127:Respiratory Distress Syndrome, Newborn / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism*
D002210:Caprylates; D014280:Triglycerides; C003637:tricaprylin
Bestimmung der Oxydationsrate mittelkettiger Triglyceride bei Neugeborenen mit dem 13C-Trioctanoin-Atemtest.