[Cellular effects of electric shock. Definitions, physical principles, cellular electrophysiology and morphological analysis of the shocked areas].
In this experimental study the electrophysiological changes induced by electric discharges such as used clinically in some arrhythmias refractory to the usual treatments were investigated. With energies comprised between 2 and 80 joules profound modifications of the electrophysiological properties of muscle cells and conduction were observed. These modifications included loss of resting potential, inactivation of the fast sodium flux, increase in refractory periods of conduction and disorders of conduction through the shocked areas with, at most, complete block sometimes reversible when low-energy currents were used. With the same amounts of energy these effects were maximal when the current traversed tissues positioned between the electrodes and decreased in all other cases. Usually, with currents of 10 joules or more all electric activity ceased in a radius of about one centimetre around the shocked area.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000628:therapy; D004553:Electric Conductivity; D004554:Electric Countershock; D004556:Electric Injuries / Q000503:physiopathology; D004594:Electrophysiology; D006327:Heart Block / Q000503:physiopathology; D006329:Heart Conduction System / Q000502:physiology*; D006335:Heart Injuries / Q000503:physiopathology; D006801:Humans; D008564:Membrane Potentials; D009206:Myocardium / Q000473:pathology; D011690:Purkinje Fibers / Q000473:pathology / Q000502:physiology*
Effets cellulaires des chocs électriques. Définitions, principes physiques, électrophysiologie cellulaire et analyse morphologique des zones choquées.