Lymphokine effect upon the erythrocyte antibody uptake by human monocytes.
Preincubation of human monocytes with different amounts of human lymphokine at 37 degrees C dose dependently increased the uptake of EA cells at both 37 degrees C and 4 degrees C. Phenylmethanesulphonyl fluoride (PMSF), an inhibitor of serine esterases, inhibited the process. It seemed that the serine esterase and not the gamma interferon component of the lymphokine played the main role in the phenomenon.
D000818:Animals; D000906:Antibodies; D002448:Cell Adhesion; D004912:Erythrocytes / Q000276:immunology*; D004950:Esterases / Q000037:antagonists & inhibitors; D006801:Humans; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000494:pharmacology; D007961:Leukocyte Migration-Inhibitory Factors / Q000494:pharmacology; D008222:Lymphokines / Q000494:pharmacology*; D009000:Monocytes / Q000276:immunology*; D010587:Phagocytosis; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology; D012397:Rosette Formation; D012756:Sheep
D000906:Antibodies; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines; D010664:Phenylmethylsulfonyl Fluoride; D007371:Interferon-gamma; D004950:Esterases; C022635:serine esterase