title: Inhibitory effects of fungi on aggregation of rabbit platelets and rat polymorphonuclear leucocytes in vitro.
abstract: Fungi of six families, encompassing 28 species, have been screened for their inhibitory effects on adenosine-5'-diphosphate (ADP), acetyl-glyceryl-phosphorylcholine (PAF) or collagen-induced rabbit platelet aggregation. Some fungi have also been studied for their ability to inhibit neutrophil aggregation induced by calcium ionophore A 23187. The results suggest that fungi may be a potential source of inhibitors of platelet and neutrophil aggregation.
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002449:Cell Aggregation / Q000187:drug effects; D003094:Collagen / Q000494:pharmacology; D003956:Dialysis; D005612:Freeze Drying; D005658:Fungi / Q000032:analysis / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009504:Neutrophils / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits
chemical_list: D000001:Calcimycin; D000244:Adenosine Diphosphate; D003094:Collagen