[In vitro activity of 3 fluoroquinolones on Branhamella catarrhalis].
The in vitro antibacterial activities of three fluoroquinolones (pefloxacin, ofloxacin, ciprofloxacin) against 90 clinical isolates of Branhamella catarrhalis were assessed by determination of minimum inhibitory concentrations (MICs). 73.5% of the strains were producing penicillinase. The MICS90 were as follow: ciprofloxacin = 0.2 mg/l. The MIC50 and the MIC90 were similar. There was no correlation of MICs with beta-lactam resistance. Lung parenchyma and bronchial mucus diffusion of these three fluoroquinolones allowed their utilisation in Branhamella catarrhalis bronchopulmonary infections.
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001424:Bacterial Infections / Q000188:drug therapy; D002939:Ciprofloxacin / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects* / Q000302:isolation & purification; D015242:Ofloxacin / Q000494:pharmacology; D015366:Pefloxacin / Q000494:pharmacology; D012141:Respiratory Tract Infections / Q000188:drug therapy
D000890:Anti-Infective Agents; D015366:Pefloxacin; D002939:Ciprofloxacin; D015242:Ofloxacin
Etude in vitro de trois fluoroquinolones sur Branhamella catarrhalis.