Computed tomography: pathologic correlation in lung disease due to tocainide.
High resolution computed tomography (CT) was used to demonstrate the active lung phase of a patient with tocainide pulmonary toxicity. Gallium uptake in the lungs, an interstitial pneumonitis with alveolar macrophages on transbronchial biopsy, and reversal of process with discontinuation of the drug indicate a pulmonary drug reaction. The high resolution CT scan defined alveolar and interstitial components to the lung abnormality and correlated closely with the pathologic findings. High resolution CT is a useful method for demonstration of fine lung morphology.
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001706:Biopsy; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects / Q000031:analogs & derivatives*; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D016677:Tocainide; D014057:Tomography, X-Ray Computed
D000889:Anti-Arrhythmia Agents; D016677:Tocainide; D008012:Lidocaine