Dose-response, meal-stimulated gastric antisecretory study of prostaglandin E1 analog, misoprostol, in man.
In a randomized, double-blind, crossover trial, the effects of 50-, 100-, and 200-micrograms doses of misoprostol on meal-stimulated gastric acid secretion were compared with placebo in 16 healthy male subjects. Compared with placebo, the 100- and 200-microgram doses produced significant reductions in acid output for 2 and 3 hr, respectively, following the test meal (P = 0.05). Misoprostol did not influence either the fasting or postprandial serum gastrin levels as compared with placebo. No adverse experiences were reported by any of the subjects. One subject experienced a transient rise in SGPT as compared with baseline, which may have been due to ethanol intake. This study provides a scientific rationale on which to base additional trials of misoprostol in patients with disease related to gastric acid production.
D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004341:Drug Evaluation; D005502:Food; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male; D016595:Misoprostol; D011897:Random Allocation
D000897:Anti-Ulcer Agents; D005755:Gastrins; D016595:Misoprostol; D000527:Alprostadil