[Prolongation of survival of allogeneic beta cells using antireceptor serum in rats with alloxan diabetes].
Some experiments were staged to unravel opportunities for prolongation of the period of functioning of allogenic beta-cells in the body of rats with alloxan diabetes using syngeneic antireceptor serum. Wistar rats were recipients, August rats--donors. Antireceptor serum obtained in Wistar rats immunized with syngeneic activated in vivo August rat blood leucocytes, was administered in single doses of 0.5 and 1 ml directly after intrahepatic injection of the islet tissue suspension. The functional indices and results of a histological analysis performed 2.5 mos. after transplantation indicated that a considerable (2.5 mos.) increase in the period of functioning of transplanted cells was noted in animals receiving a lower serum dose.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000276:immunology / Q000628:therapy*; D006085:Graft Survival; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007106:Immune Sera / Q000276:immunology*; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000276:immunology; D016381:Islets of Langerhans Transplantation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011946:Receptors, Antigen / Q000276:immunology*; D014185:Transplantation, Isogeneic
D000949:Histocompatibility Antigens Class II; D007106:Immune Sera; D011946:Receptors, Antigen
Prolongirovanie zhiznedeiatel'nosti allogennykh beta-kletok s pomoshch'iu antiretseptornoĭ syvorotki u krys s alloksanovym diabetom.