[Nucleolytic action of chondroitinase ABC on the lumbar disc of the rabbit].
Nucleolysis using chondroitinase ABC was studied using the rabbit's intervertebral lumbar disc. The purpose was to find a possible alternative to chymopapain which is commonly used in the management of sciatica due to disc herniation. The injection of 1 U of the enzyme into the nucleus pulposus gave significant histological and biochemical changes in all twelve discs studied.
D000818:Animals; D002808:Chondroitin Lyases / Q000378:metabolism*; D002810:Chondroitinases and Chondroitin Lyases / Q000378:metabolism*; D002917:Chymopapain / Q000378:metabolism; D007404:Intervertebral Disc Chemolysis; D008159:Lumbar Vertebrae / Q000378:metabolism* / Q000648:ultrastructure; D011509:Proteoglycans / Q000378:metabolism; D011817:Rabbits
D011509:Proteoglycans; D002917:Chymopapain; D002808:Chondroitin Lyases; D002810:Chondroitinases and Chondroitin Lyases
Etude de l'action nucléolytique de la chondroïtinase ABC sur le disque lombaire du lapin.