Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8.
Linkage relationships of the gene for peripheral neurofibromatosis (NF) were assessed in a large American Caucasian pedigree using two DNA markers located on chromosome 8. Linkage to the thyroglobulin locus, located at 8q24, was excluded (lod less than or equal to -2.0) to 21 cM. Data obtained for the tissue plasminogen activator locus, located at 8p12, excluded linkage to 4 cM. These results exclude between 20 to 30% of chromosome 8 as a possible map location for the NF gene in this family. Comparison of the two DNA markers excluded their linkage to 0.5 cM.
D002898:Chromosomes, Human, Pair 8; D004247:DNA / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D009456:Neurofibromatosis 1 / Q000235:genetics*; D013954:Thyroglobulin / Q000235:genetics; D010959:Tissue Plasminogen Activator / Q000235:genetics
D005819:Genetic Markers; D004247:DNA; D013954:Thyroglobulin; D010959:Tissue Plasminogen Activator