title: Plasmodium vivax malaria in the common marmoset, Callithrix jacchus: adaptation and host response to infection.
abstract: Infection with Plasmodium vivax was established in splenectomized Callithrix jacchus marmosets by inoculation of parasitized blood from Aotus trivirgatus carrying the Vietnam Palo-Alto line of P. vivax. Subsequent blood passage through intact marmosets resulted in higher peak parasitaemias (about 1% of red cells infected) and the loss of stainable Schüffner's dots in infected cells. Primary infections with the adapted line were patent for 74 days or more, and induced both a substantial antibody response, as determined by indirect fluorescence, and some lymphocytosis, but no marked anaemia. Marmosets which had recovered from their primary infection (or in which it was drug-cured) suffered abbreviated patency with low-grade parasitaemia on re-infection.
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D002144:Callithrix / Q000469:parasitology*; D002143:Callitrichinae / Q000469:parasitology*; D004195:Disease Models, Animal; D005260:Female; D005455:Fluorescent Antibody Technique; D007074:Immunoglobulin G / Q000032:analysis; D007958:Leukocyte Count; D008288:Malaria / Q000276:immunology / Q000662:veterinary*; D008297:Male; D010966:Plasmodium vivax; D013156:Splenectomy
chemical_list: D000913:Antibodies, Protozoan; D007074:Immunoglobulin G