Stress-induced-antinociception and morphine sensitivity in mice following chronic treatment with anabolic/androgenic steroids.
In male mice treated chronically with anabolic/androgenic steroids, morphine produced changes in exploratory behaviour similar to those normally associated with anxiolytic drugs. In addition, steroid treatment attenuated opioid-mediated stress-induced antinociception.
D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D013312:Stress, Physiological / Q000503:physiopathology*
D000728:Androgens; D009020:Morphine