Effect of D,L-alpha-difluoromethyl ornithine on cleft palate induced by the TCDD congener, 3,3',4,4'-tetrachloroazoxybenzene, in the fetuses of mice.
The importance of inhibition of ornithine decarboxylase (ODC) activity in murine embryonic tissues for the teratogenic action of the TCDD congener 3,3',4,4'-tetrachloroazoxybenzene (TCAOB), has been studied. When D,L-alpha-difluoromethyl ornithine (DFMO), an inhibitor of ODC activity, was coadministered with TCAOB, it decreased the frequency of cleft palate compared with TCAOB alone. Fetal death induced by TCAOB was not affected by DFMO treatment. It is suggested that the mechanism of cleft palate induced by TCAOB may involve ODC stimulation. However fetal death induced by the latter compound may involve another mechanism, that may not be related to the mechanism of cleft palate induction.
D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D002722:Chlorobenzenes / Q000633:toxicity*; D002972:Cleft Palate / Q000139:chemically induced*; D000518:Eflornithine / Q000494:pharmacology*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D051379:Mice; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity; D011247:Pregnancy
D001391:Azo Compounds; D002722:Chlorobenzenes; D000072317:Polychlorinated Dibenzodioxins; C013279:3,4,3',4'-tetrachloroazobenzene; D000518:Eflornithine