Histologic changes in the guinea pig gastrointestinal tract following 1 weeks' administration of chlorpromazine, haloperidol or atropine.
A comparison was made between the toxic effects of chronic chlorpromazine, haloperidol or atropine on the guinea pig intestinal tract. Chlorpromazine, administered at a dose of 30 mg/kg/day, IP for 7 days, produced marked pathologic changes in the guinea pig cecum, consisting of inflammation, edema and hemorrhage. None of these effects were noted when haloperidol, 2 or 10 mg/kg/day or atropine 30 mg/kg/day were similarly administered. Similar toxic effects may occur in humans on long-term chlorpromazine or other phenothiazine therapy, thereby accounting for the paralytic ileus observed with these drugs.
D000818:Animals; D001285:Atropine / Q000633:toxicity*; D002746:Chlorpromazine / Q000633:toxicity*; D004064:Digestive System / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D006220:Haloperidol / Q000633:toxicity*; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000473:pathology; D009197:Myenteric Plexus / Q000187:drug effects / Q000473:pathology
D001285:Atropine; D006220:Haloperidol; D002746:Chlorpromazine