Receptor adaptive responsiveness in disease models: 6-OHDA lesioned and spontaneously hypertensive rats.
We have examined the adaptive modifications of brain monoamine receptors in response to pathophysiological processes in animal disease models: 6-OHDA lesioned and spontaneously hypertensive rats (SHR). The two models share a similar increase in D-1 receptor densities, while noradrenergic receptors are affected in different way: alpha-1 and beta are supersensitive in 6-OHDA lesioned rats and only alpha-2 are increased in SHR. S-1 receptors too are up-regulated in SHR. We must notice that though receptor hypersensitivity in the 6-OHDA model is linked to massive decreases in neurotransmitter levels, this mechanism seems not to exist in the SHR model.
D000818:Animals; D001923:Brain Chemistry; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D006892:Hydroxydopamines / Q000633:toxicity; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism
D006892:Hydroxydopamines; D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D012701:Serotonin; D016627:Oxidopamine; D004298:Dopamine; D009638:Norepinephrine