The pharmacologic induction of prolactin release in the medial preoptic/suprachiasmatic nuclei-lesioned, estrogen-treated ovariectomized rat.
It has been shown that lesions of the medial preoptic/suprachiasmatic nuclei (MPO/SCN) abolish the estrogen-induced afternoon prolactin (PRL) surge. Recent studies using both dopamine antagonist and thyrotropin-releasing hormone (TRH) successfully induced an increase in plasma PRL in various animal models. The same drug approach was used in this study in the MPO/SCN lesioned rat to determine whether these areas participated in the induced PRL release. It is concluded that a significant PRL release can be induced by DA antagonism, or TRH stimulation preceded by DA antagonism in the MPO/SCN lesioned, estrogen-treated ovariectomized rat.
D000818:Animals; D002940:Circadian Rhythm; D004294:Domperidone / Q000008:administration & dosage / Q000494:pharmacology*; D018492:Dopamine Antagonists; D004357:Drug Synergism; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D010052:Ovariectomy; D011301:Preoptic Area / Q000502:physiology*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013493:Suprachiasmatic Nucleus / Q000502:physiology*; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*
D018492:Dopamine Antagonists; D004967:Estrogens; D004294:Domperidone; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin