Neurofibrillary tangles and the neuronal cytoskeleton.
Antibodies to neurofilaments and the microtubule-associated protein, tau, have been used with anti-paired helical filament (PHF) serum to study Alzheimer neurofibrillary tangles. Tangles and their constituent PHF contain epitopes derived from or cross-reactive with both neurofilaments and tau proteins. These same structures are labelled with anti-PHF antibodies. A component of the anti-PHF serum is against tau proteins. We conclude that PHF are at least in part derived from an abnormal neuronal cytoskeleton.
D000544:Alzheimer Disease / Q000473:pathology*; D000911:Antibodies, Monoclonal; D001923:Brain Chemistry; D003599:Cytoskeleton / Q000032:analysis*; D006801:Humans; D007382:Intermediate Filaments / Q000032:analysis; D008869:Microtubule-Associated Proteins / Q000032:analysis; D009454:Neurofibrils / Q000032:analysis*; D016875:tau Proteins
D000911:Antibodies, Monoclonal; D008869:Microtubule-Associated Proteins; D016875:tau Proteins