title: Thyroid function and bipolar affective disorder.
abstract: Thyroid function tests and life course of illness were evaluated in 42 patients with bipolar affective disorder who had received at least 3 months of lithium carbonate treatment. Eight of 42 patients (19%) required thyroid replacement or had evidence of subclinical hypothyroidism associated with lithium treatment. Abnormalities of thyroid function were related to female sex and duration of lithium treatment but not to a rapid-cycling course of illness.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced*; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D013963:Thyroid Hormones; D016651:Lithium Carbonate; D008094:Lithium