title: The effect of lumbar sympathectomy on postsynaptic vascular smooth muscle response in the lower limb in dogs.
abstract: The intent of this experiment was to study the postsynaptic vasoactive response to tolazoline hydrochloride and sodium-meglumine diatrizoate (Renografin-76) after a unilateral lumbar sympathectomy in a dog model. Both lower extremities were examined using the video dilution technique before and 1-2 weeks after unilateral lumbar sympathectomy (SE). Results showed (1) resting blood flow in the femoral artery as a percentage of cardiac output did not change after sympathectomy (mean and SD before and after SE: 7.0% +/- 2.3 and 6.0% +/- 2.9 respectively n = 13); (2) the reactive hyperemia in the femoral artery caused by sodium-meglumine diatrizoate (Renografin-76) was unchanged after sympathectomy; (3) the vasodilator effect of tolazoline hydrochloride decreased significantly after sympathectomy (p less than 0.05).
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D003287:Contrast Media / Q000494:pharmacology*; D003973:Diatrizoate / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000494:pharmacology*; D004285:Dogs; D004338:Drug Combinations / Q000494:pharmacology; D006614:Hindlimb / Q000098:blood supply; D008161:Lumbosacral Region; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D012039:Regional Blood Flow; D013562:Sympathectomy; D014043:Tolazoline / Q000494:pharmacology*; D014666:Vasomotor System / Q000187:drug effects*
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; C027278:urovision; D014043:Tolazoline