Ifosfamide/mesna related encephalopathy: a case report with a possible role of phenobarbital in enhancing neurotoxicity.
A case of reversible encephalopathy after one dose of ifosfamide/mesna in an epileptic 15-year-old girl is reported. No other pathology could be responsible for the symptoms. An epilepsy or a toxicity induced by vincristine were discussed. Nevertheless, the possible role of phenobarbital, known to induce hepatic microsomal activity, seems the more probable mechanism.
D000293:Adolescent; D001927:Brain Diseases / Q000139:chemically induced*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects*; D008623:Mercaptoethanol / Q000031:analogs & derivatives*; D015080:Mesna / Q000009:adverse effects*; D010634:Phenobarbital / Q000378:metabolism / Q000627:therapeutic use
D008623:Mercaptoethanol; D015080:Mesna; D007069:Ifosfamide; D010634:Phenobarbital