P2-purinergic receptors in vascular endothelial cells: from concept to reality.
ATP exerts at least 2 actions on arterial endothelial cells: it stimulates the release of endothelium-derived relaxing factor, a still unidentified vasodilator, and of prostacyclin, a potent inhibitor of platelet aggregation. A study of agonist specificity indicates that these responses are mediated by P2-purinergic receptors. We have now demonstrated that in these cells, the P2-receptors are coupled to a phospholipase C hydrolysing phosphatidylinositol-bisphosphate and that this coupling involves a pertussis toxin-sensitive GTP-binding regulatory protein.
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D001688:Biological Products / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D011464:Epoprostenol / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate; D007295:Inositol Phosphates / Q000378:metabolism; D008954:Models, Biological; D009569:Nitric Oxide; D037342:Pertussis Toxin; D011983:Receptors, Purinergic / Q000187:drug effects* / Q000502:physiology; D012636:Secretory Rate / Q000187:drug effects; D010738:Type C Phospholipases / Q000378:metabolism; D010566:Virulence Factors, Bordetella / Q000494:pharmacology
D001688:Biological Products; D007295:Inositol Phosphates; D011983:Receptors, Purinergic; D010566:Virulence Factors, Bordetella; D009569:Nitric Oxide; D015544:Inositol 1,4,5-Trisphosphate; D000255:Adenosine Triphosphate; D011464:Epoprostenol; D037342:Pertussis Toxin; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins