[Effect of eicosanoids on the accumulation of cholesterol and the proliferation of subendothelial cells in the human aorta].
The effect of prostacyclin and stable thromboxane analog A2 on endothelial culture of human aorta was studied. It was shown that prostacyclin inhibited accumulation of cholesterol in the cells and their proliferation, while thromboxane exhibited an opposite effect. Calcium antagonists potentiated effects of prostacyclin and inhibited them in respect to thromboxane. Screening of a number of synthetic agents affecting arachidonic acid metabolism was carried out. It was found that lipoxygenase inhibitors suppress cholesterol accumulation and proliferation in cells presumably due to enhancement of prostacyclin synthesis and inhibition of leukotriene formation. The balance between various eicosanoids is supposed to be an important factor of atherogenesis regulation, while antiatherogenic effect of calcium antagonists is somehow associated with the impact of eicosanoids on atherogenesis regulation.
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000328:Adult; D001011:Aorta / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects*; D002784:Cholesterol / Q000096:biosynthesis*; D011464:Epoprostenol / Q000494:pharmacology* / Q000031:analogs & derivatives; D006801:Humans; D066298:In Vitro Techniques; D016859:Lipoxygenase Inhibitors; D008297:Male; D008875:Middle Aged; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D016859:Lipoxygenase Inhibitors; D011450:Prostaglandin Endoperoxides, Synthetic; C026678:carboprostacyclin; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D002784:Cholesterol; D011464:Epoprostenol
Vliianie éĭkozanoidov na nakoplenie kholesterina i proliferatsiiu subéndotelial'nykh kletok aorty cheloveka.