title: Gallium citrate, a new sensitizer of cells to hyperthermia.
abstract: The killing effects of heat were studied on cultured mammalian cells (L5178Y) pre-incubated with gallium (Ga) citrate, which is a popular tumor-imaging diagnostic agent. The cells showed higher sensitivity to heat when they were pre-incubated with Ga-citrate. The pre-incubated cells showed decreased ATP levels, and this may be responsible for the heat-sensitizing effect.
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005710:Gallium Radioisotopes / Q000494:pharmacology*; D006358:Hot Temperature; D051379:Mice; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D005710:Gallium Radioisotopes