title: [Metabolism of prostaglandins and their precursors in inhalational acetaldehyde poisoning].
abstract: Rats were kept for 10 days (8 hours per day) in a chamber where acetaldehyde vapour concentration was 2.5-3.0 g/m3. The animal liver levels of prostaglandins E2 and F2 alpha decreased, the activities of linoleoyl CoA desaturase and PG synthetases reduced. The content of arachidonic acid in the total lipid fraction increased. The decrease of PG synthesis under chronic alcoholic intoxication is supposed to be implemented through two mechanisms, one of which is acetaldehyde-mediated.
mesh_terms: D000079:Acetaldehyde / Q000378:metabolism / Q000506:poisoning*; D000437:Alcoholism / Q000378:metabolism; D000818:Animals; D004781:Environmental Exposure; D044943:Fatty Acid Desaturases / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D050602:Linoleoyl-CoA Desaturase; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats
chemical_list: D005227:Fatty Acids; D011453:Prostaglandins; D044943:Fatty Acid Desaturases; D050602:Linoleoyl-CoA Desaturase; D011451:Prostaglandin-Endoperoxide Synthases; D000079:Acetaldehyde
vernacular_title: Obmen prostaglandinov i ikh predshestvennikov pri ingaliatsionnoĭ intoksikatsii atsetal'degidom.