A comparison of the pharmacokinetics of 14C-labelled APD and 99mTc-labelled APD in the mouse.
The disposition of 14C-labelled and 99mTc-labelled APD has been investigated in the Balb/c mouse following a single ip injection containing APD (total dose 5 mg/kg) labelled partly with carbon-14 and partly with technetium-99m. The plasma clearance of carbon-14 was twice that for technetium-99m and the accumulation of carbon-14 in bone was twice as great as that of technetium-99m. All other tissues assayed (liver, lung, kidney and muscle) contained higher concentrations of technetium-99m than carbon-14. There was a particularly marked accumulation of technetium-99m in the liver. We conclude that pharmacokinetic studies of diphosphonates cannot be conducted reliably with 99mTc-labelled compounds.
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects; D002250:Carbon Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004164:Diphosphonates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007267:Injections; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009132:Muscles / Q000187:drug effects; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds; D000077268:Pamidronate
D002250:Carbon Radioisotopes; D004164:Diphosphonates; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; C039598:technetium Tc 99m 3-amino-1-hydroxypropane-1,1-diphosphonate; D000077268:Pamidronate