Presence of an inhibitor of glycosyltransferase activity in a patient following an ABO incompatible liver transplant.
The contribution of the liver to plasma ABO glycosyltransferase activity has been studied in a group O individual transplanted with a liver from a group B donor. The B transferase activity present in the post-transplantation plasma was negligible. However, a potent B transferase inhibitor, absent from the pretransplantation plasma, was present after transplantation. The inhibitor was present in the excluded fraction following Sephadex G-25 gel filtration, but was retained by a protein A-Sepharose column, suggesting that it was an IgG antibody. This inhibitor was also effective in reducing A transferase activity.
D000017:ABO Blood-Group System / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000201:enzymology / Q000276:immunology*; D002648:Child; D005700:Galactosyltransferases / Q000037:antagonists & inhibitors*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D017350:N-Acetylgalactosaminyltransferases
D000017:ABO Blood-Group System; D005700:Galactosyltransferases; D017350:N-Acetylgalactosaminyltransferases; C003742:UDPgalactosamine-galactose acetylgalactosaminyltransferase