title: Comparison of the efficacy of "Trisdine" and kanamycin-colistin bladder instillations in reducing bacteriuria during intermittent catheterisation of patients with acute spinal cord trauma.
abstract: An open, prospective, randomised, comparative study of "Trisdine" and kanamycin-colistin bladder instillations in reducing significant bacteriuria during intermittent urethral catheterisation was conducted. Trisdine is an aqueous solution of chlorhexidine gluconate 0.01% with added ethylenediaminetetra-acetic acid disodium salt and TRIS buffer at final concentrations of 1.34 mMoles and 0.01 Molar respectively. All patients (15 males and 3 females) admitted with acute spinal cord trauma and bladder involvement requiring intermittent catheterisation for more than 5 days during a 12-month period were studied. There was no significant difference in the mean incidence of significant bacteriuria during intermittent catheterisation in the 7 males who had kanamycin-colistin bladder instillations compared with the 8 males who had Trisdine instillations. A comparison could not be made in the females because there were only 3 patients. Because Trisdine is more stable at ambient temperatures, is less likely to select antibiotic-resistant bacteria and is less expensive, it is concluded that Trisdine is preferable to kanamycin-colistin solution for bladder instillations during intermittent catheterisation.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000627:therapeutic use*; D001437:Bacteriuria / Q000209:etiology / Q000517:prevention & control*; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003091:Colistin / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D004492:Edetic Acid / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007612:Kanamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011897:Random Allocation; D013119:Spinal Cord Injuries / Q000628:therapy*; D014325:Tromethamine / Q000627:therapeutic use*; D014546:Urinary Catheterization / Q000009:adverse effects*
chemical_list: D000892:Anti-Infective Agents, Urinary; D004338:Drug Combinations; D014325:Tromethamine; C056968:Trisdine; D007612:Kanamycin; D004492:Edetic Acid; D002710:Chlorhexidine; D003091:Colistin