title: The carry-over effect on the bowel habit in elderly long-term patients of long-term bulk-forming products containing stimulant laxative.
abstract: This study was undertaken to investigate the possible carry-over effect on elderly long-term patients of bulk-forming products containing stimulant type laxatives. Thirty-six patients received magnesium hydroxide daily for a mean period of 10 months prior to the study, and 23 patients received bulk laxatives containing cassiae senna daily for a mean period of 13 months prior to the study. The pre-study laxatives were randomly changed either to magnesium hydroxide or to bulk laxatives. In the patient group receiving a bulk-forming product containing stimulant type laxative long-term prior to the study, the need for additional stimulant laxatives during the pure bulk laxative (3.0 vs. 3.8/4 weeks, NS) or magnesium hydroxide treatment (2.6 vs. 2.7/4 weeks, NS) was not more frequent and the frequency of defaecation was not lower than in the patients (during bulk laxative 11.2 vs. 9.3/4 weeks, NS and during magnesium hydroxide 12.0 vs. 13.7/4 weeks, NS) who received long-term magnesium hydroxide treatment prior to the study. Thus, our data indicated no carry-over effect after the use of bulk-forming laxatives containing senna for 13 months in elderly long-term patients.
mesh_terms: D000368:Aged; D002400:Cathartics / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008134:Long-Term Care; D008274:Magnesium / Q000008:administration & dosage*; D008276:Magnesium Hydroxide / Q000008:administration & dosage*; D011897:Random Allocation; D012676:Senna Extract / Q000008:administration & dosage
chemical_list: D002400:Cathartics; D012676:Senna Extract; D008274:Magnesium; D008276:Magnesium Hydroxide