Nonsecretory IgD (kappa) multiple myeloma. Report of a case and review of the literature.
The authors have reviewed five cases of the nonsecretory IgD multiple myeloma (MM), including a newly observed case investigated in the authors' laboratory. The salient features of these five cases were summarized to allow a better understanding of this entity. The following clinical points should be noted: (1) All nonsecretory IgD MMs reported had kappa light chains, which are rarely seen in usual IgD MM. (2) All the cases were found in women. (3) The presence of monoclonal B-lymphocytes bearing surface IgD (kappa) in the peripheral blood was demonstrated in three of four patients whose B-cell subpopulation was mentioned. (4) Generally speaking, nonsecretory IgD (kappa) MM showed the combined features of usual IgD MM and nonsecretory MM. It seems likely that IgD (kappa), nonsecretory MM is more than might be expected to occur by chance. The pathogenesis of this entity is discussed in this report.
D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D007072:Immunoglobulin D / Q000032:analysis*; D007138:Immunoglobulin delta-Chains / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000276:immunology* / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology
D007072:Immunoglobulin D; D007138:Immunoglobulin delta-Chains; D007145:Immunoglobulin kappa-Chains