Malignant angioendotheliomatosis--a true lymphoma: a case of intravascular malignant lymphomatosis studied by southern blot hybridization analysis.
Malignant angioendotheliomatosis is a rare, systemic, usually fatal disease characterized by a massive proliferation of large, bizarre-looking mononuclear cells within small and medium-sized blood vessels. The histogenesis of the neoplastic cells has been the subject of long-standing controversy since the disease's initial description. Early investigators concluded that the entity represented a neoplasm of endothelial cells, but recently others have suggested that it is of lymphoid origin. We studied a case of malignant angioendotheliomatosis by Southern blot hybridization analysis which showed clonal rearrangements of the immunoglobulin heavy-chain gene strongly suggesting a B-lymphocyte origin. Our results provide additional evidence that malignant angioendotheliomatosis is an intravascular malignant lymphomatosis.
D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology; D001808:Blood Vessels / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis*; D005803:Genes, Immunoglobulin; D006390:Hemangioendothelioma / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D008297:Male; D009693:Nucleic Acid Hybridization; D014652:Vascular Diseases / Q000473:pathology*
D004273:DNA, Neoplasm; D007143:Immunoglobulin Heavy Chains