Synergistic activation of human T cells by interleukin 1 and interleukin 6.
Purified human interleukin 6 (IL 6) was found to stimulate the proliferation of human tonsillar and peripheral rosetting T cells subliminally activated with phytohemagglutinin (PHA). This response seemed independent of IL 2 but highly dependent on the presence of accessory cells. Indeed, when accessory cell-depleted tonsillar T cells were activated with PHA and exposed to IL 6, only minimal proliferations were observed. A similar result was obtained with IL 1. However, a combination of these two cytokines induced strong proliferations, indicating that IL 1 and IL 6 plays a synergistic role in the interactions between accessory cells and T lymphocytes.
D000938:Antigen-Presenting Cells / Q000276:immunology; D004357:Drug Synergism; D006133:Growth Substances; D006801:Humans; D007375:Interleukin-1 / Q000008:administration & dosage*; D015850:Interleukin-6; D007378:Interleukins / Q000008:administration & dosage*; D008213:Lymphocyte Activation / Q000187:drug effects*; D011971:Receptors, Immunologic / Q000502:physiology; D015375:Receptors, Interleukin-2; D013601:T-Lymphocytes / Q000276:immunology*
D006133:Growth Substances; D007375:Interleukin-1; D015850:Interleukin-6; D007378:Interleukins; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2