Rapid and specific lowering of pituitary FSH beta mRNA levels by inhibin.
Hypothalamo-pituitary disconnected sheep were given gonadotropin releasing hormone pulses every 2 h for 1 week, and the effects of inhibin on mRNA for FSH beta, LH beta, alpha-subunit and prolactin examined. Levels of FSH beta mRNA were reduced to approximately 20% 6 h after administration, and to approximately 10% by 30 h; no change was seen in LH beta, alpha-subunit or prolactin mRNA. These data show that inhibin has a very rapid and specific effect on FSH beta mRNA levels directly at the level of the pituitary gland.
D000818:Animals; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D037201:Follicle Stimulating Hormone, beta Subunit; D006062:Gonadotropins / Q000097:blood; D007265:Inhibins / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000378:metabolism; D009693:Nucleic Acid Hybridization; D010052:Ovariectomy; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D010906:Pituitary Hormone-Releasing Hormones; D011388:Prolactin / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012756:Sheep
D037201:Follicle Stimulating Hormone, beta Subunit; D006062:Gonadotropins; D010906:Pituitary Hormone-Releasing Hormones; D012333:RNA, Messenger; D007265:Inhibins; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone