title: Increased lipid peroxidation after lipid infusion as measured by breath pentane output.
abstract: We studied the effect of intravenous lipid infusion on lipid peroxidation as measured by breath pentane. Pentane, plasma alpha-tocopherol (alpha-tox) and plasma gamma-tocopherol (gamma-toc), selenium, and Se-dependent glutathione peroxidase (Se-GSHPx) were measured in 10 normal control subjects and in 10 home parenteral nutrition (HPN) patients before and after infusion of 100 mL Nutralipid 10% over 30 min. Before infusion, breath pentane was significantly higher and alpha-toc was significantly lower in the HPN group than in the control subjects. These two measurements were significantly negatively correlated (r = -0.54, p less than 0.05). Pentane, alpha-toc, and Se-GSHPx were significantly increased in both groups after lipid was infused but were still significantly higher in HPN patients than in control subjects. Thus, infusion of a small amount of lipid rich in linoleic acid induced a significant increase in breath pentane, reflective of increased lipid peroxidation.
mesh_terms: D000328:Adult; D001944:Breath Tests; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D010420:Pentanes / Q000032:analysis*; D012643:Selenium / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D005217:Fat Emulsions, Intravenous; D008054:Lipid Peroxides; D010420:Pentanes; D014280:Triglycerides; D014810:Vitamin E; C033353:pentane; D012643:Selenium