Synthesis of glycosaminoglycans by islets of Langerhans.
Incorporation of (35S)-sulfate into glycosaminoglycans (GAG) of toadfish islets of Langerhans in vitro was examined. (35S)-sulfated GAG were synthesized by a component of the microsomal fraction, and subsequently transferred to the secretion granules, mitochondria and nuclei. The predominant type of GAG synthesized was heparan sulfate, but chondroitin 4- and 6-sulfate and dermatan sulfate were also found.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002809:Chondroitin Sulfates / Q000096:biosynthesis; D003594:Cytoplasmic Granules / Q000378:metabolism; D003871:Dermatan Sulfate / Q000096:biosynthesis; D005399:Fishes / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000096:biosynthesis*; D006497:Heparan Sulfate / Q000096:biosynthesis; D007515:Islets of Langerhans / Q000378:metabolism* / Q000648:ultrastructure; D008861:Microsomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D013431:Sulfates / Q000378:metabolism
D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D006025:Glycosaminoglycans; D006497:Heparan Sulfate; D013431:Sulfates