[Preventive and therapeutic action of sera to the Re mutant of Salmonella minnesota in experimental generalized meningococcal infection].
The preparations of the blood plasma of humans and the sera of animals immunized with enterobacterial vaccine proved to have elevated titers of antibodies to deep determinants of the core of the gram-negative bacterial endotoxin molecule (to glycolipid of chemotype Re) and protected animals from infection with live cultures or serogroup A, B, or C meningococcal endotoxins. Sera from nonimmunized animals and normal donor blood plasma showed no protective activity. In experiments carried out on different models immune plasma possessed both a pronounced protective activity and a curative effect. The efficacy of protection depended not on the serogroup of the infective agent, but on the virulence of the strain used in the experiment, being statistically significant in all cases.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004731:Endotoxins / Q000276:immunology; D006801:Humans; D007106:Immune Sera / Q000302:isolation & purification*; D007114:Immunization; D007116:Immunization, Passive; D008585:Meningitis, Meningococcal / Q000517:prevention & control* / Q000628:therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D009345:Neisseria meningitidis / Q000276:immunology; D011817:Rabbits; D012475:Salmonella / Q000276:immunology*
D004731:Endotoxins; D007106:Immune Sera
Preventivnoe i lechenoe deĭstvie syvorotok k Re-mutantu Salmonella minnesota pri éksperimental'noĭ generalizovannoĭ meningokokkovoĭ infektsii.