An enhancer factor defect in a mutant Burkitt lymphoma cell line.
RJ 2.2.5 is an immunoselected mutant of the Burkitt lymphoma line Raji. It fails to display MHC class II antigens at the cell surface due to a transcriptional defect. We have identified the function of a regulatory factor that is defective in RJ 2.2.5 cells; this factor is absolutely required for the activity of an MHC class II gene enhancer.
D004268:DNA-Binding Proteins / Q000502:physiology*; D004742:Enhancer Elements, Genetic; D005802:Genes, MHC Class II; D006681:HLA-D Antigens / Q000235:genetics*; D006801:Humans; D012045:Regulatory Sequences, Nucleic Acid; D014407:Tumor Cells, Cultured
D004268:DNA-Binding Proteins; D006681:HLA-D Antigens