Effect of interferon gamma on expression of HLA-class II molecules on blood-derived dendritic cells.
T4 cells recognize antigen together with HLA class II molecules in the membrane of antigen-presenting cells (APC). The magnitude of the induced T cell response is in part dependent upon the quantitative expression of HLA-class II molecules in the cell membrane of the APC. We report here that recombinant interferon gamma (IFN-gamma) may enhance the expression of HLA class II molecules on the surface membrane of blood-derived dendritic cells by 30-90%.
D003713:Dendritic Cells / Q000276:immunology*; D006681:HLA-D Antigens / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000494:pharmacology*; D007700:Kinetics
D006681:HLA-D Antigens; D007371:Interferon-gamma