Cytotoxic, fungicidal nucleosides from blue green algae belonging to the Scytonemataceae.
Tubercidin, toyocamycin, and the corresponding 5'-alpha-D-glucopyranose derivatives of the nucleosides are frequently responsible for much of the cytotoxicity and antimycotic activity associated with extracts of cultured cyanophytes belonging to the family Scytonemataceae. The 5'-alpha-D-glucopyranoses of tubercidin and toyocamycin, for example, are the major cytotoxic and fungicidal nucleosides in Fijian Plectonema radiosum and Hawaiian Tolypothrix tenuis, respectively.
D000935:Antifungal Agents / Q000302:isolation & purification*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D000458:Cyanobacteria / Q000032:analysis*; D006801:Humans; D006868:Hydrolysis; D009705:Nucleosides / Q000302:isolation & purification*
D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D009705:Nucleosides