Dopaminergic D-1 receptors: essential role in morphine-induced hypermotility.
Administration of morphine HCl (20 mg/kg SC) to male C57Bl/6 mice evoked hypermotility. Pretreatment with low doses of the specific D-1 antagonist SCH 23390 (0.006, 0.012, 0.025 mg/kg SC) dose-dependently inhibited morphine-evoked hypermotility. The results suggest that dopamine is the essential mediator of opiate hypermotility and indicate that D-1 receptors play an important role in this effect.
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006948:Hyperkinesis / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009020:Morphine / Q000494:pharmacology*; D011954:Receptors, Dopamine / Q000502:physiology*
D001552:Benzazepines; D011954:Receptors, Dopamine; D009020:Morphine