How immunoglobulin V kappa genes rearrange.
Recombination at the immunoglobulin kappa light chain locus creates a complete variable region gene and its reciprocal product. The results presented here show that reciprocal products may be substrates for secondary recombination and that at least one V kappa group rearranges by inversion.
D000595:Amino Acid Sequence; D000818:Animals; D000916:Antibody Diversity; D001483:Base Sequence; D005803:Genes, Immunoglobulin; D007144:Immunoglobulin J-Chains / Q000235:genetics; D007134:Immunoglobulin Switch Region / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D051379:Mice; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010954:Plasmacytoma / Q000473:pathology; D011995:Recombination, Genetic; D014407:Tumor Cells, Cultured
D007144:Immunoglobulin J-Chains; D007135:Immunoglobulin Variable Region; D007145:Immunoglobulin kappa-Chains