[Action of gutimine on the redox status of flavin and pyridine nucleotides in intact neurons].
Redox-reactions of flavine (FN) and pyridine (PN) nucleotides of the cell to guthimine were studied by the method of fluorescent microscopy without using any stains. The comparison was made of the kinetics of fluorescence intensity of FN and PN of the Retzius intact neuron under the action of guthimine, oxaloacetate, nembutal and succinate. It is suggested that guthimine may activate the switching of oxidative metabolism of the cell over to a more energitically profitable way.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005415:Flavins / Q000378:metabolism*; D006164:Guanylthiourea / Q000494:pharmacology*; D066298:In Vitro Techniques; D007865:Leeches; D008856:Microscopy, Fluorescence; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009711:Nucleotides / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D011725:Pyridines / Q000378:metabolism*; D013890:Thiourea / Q000031:analogs & derivatives*
D005415:Flavins; D009711:Nucleotides; D011725:Pyridines; D013890:Thiourea; D006164:Guanylthiourea
Deĭstvie gutimina na redoks-sostoianie flavinovykh i piridinovykh nukleotidov intaktnykh neĭronov.