Hemofiltration clearance of flecainide in a patient with acute renal failure.
Flecainide, a new antiarrhythmic drug, has been shown not no be removed to a significant extent by hemodialysis or peritoneal dialysis, in spite of a high renal clearance. Its systemic and hemofiltrate clearances, measured in a patient under continuous hemofiltration, were 402 and 19.7 ml/min respectively. The clearance ratio of less than 5% makes the contribution of hemofiltration to the elimination of flecainide clinically negligible.
D058186:Acute Kidney Injury / Q000628:therapy*; D005424:Flecainide / Q000008:administration & dosage / Q000493:pharmacokinetics; D006440:Hemofiltration; D006801:Humans; D008297:Male; D008875:Middle Aged
D005424:Flecainide