[Decrease in the immunoreactivity of protein 7B2 in vasopressinergic cells in the supraoptic nucleus and in fibers of the neurohypophysis, in Brattleboro rats].
Immunoreactivity to the secretory protein 7B2 (IR-7B2) colocalizes with both AVP and Om in separate groups of neurons in the supraoptic nucleus. In mutant Brattleboro rats, which have aberrant AVP, which results in diabetes insipidus, 7B2 appears to be markedly decreased in vasopressinergic neurons and absent in their corresponding neurohypophyseal terminals. In contrast, no dramatic differences could be observed in oxytonergic somatas and fibers.
D000818:Animals; D008297:Male; D009412:Nerve Fibers / Q000276:immunology; D009419:Nerve Tissue Proteins; D051859:Neuroendocrine Secretory Protein 7B2; D009474:Neurons / Q000032:analysis* / Q000276:immunology; D010121:Oxytocin / Q000276:immunology; D010904:Pituitary Gland, Posterior / Q000032:analysis* / Q000276:immunology; D010907:Pituitary Hormones / Q000032:analysis* / Q000276:immunology; D051381:Rats; D011910:Rats, Brattleboro; D013495:Supraoptic Nucleus / Q000032:analysis* / Q000276:immunology; D014667:Vasopressins / Q000276:immunology
D009419:Nerve Tissue Proteins; D051859:Neuroendocrine Secretory Protein 7B2; D010907:Pituitary Hormones; C497680:Scg5 protein, rat; D014667:Vasopressins; D010121:Oxytocin
Diminution de l'immunoréactivité de la protéine "7B2" dans les cellules vasopressinergiques du noyau supraoptique et dans les fibres de la neurohypophyse, chez les rats Brattleboro.