title: Progressive myoclonus epilepsy treated with zonisamide.
abstract: Two patients with progressive myoclonus epilepsy of the Unverricht-Lundborg type and with intractable seizures in spite of standard anticonvulsant regimens were treated with zonisamide. After zonisamide therapy was initiated, both had a marked decrease in seizure frequency and significant improvement of functioning. Serum zonisamide concentrations were 43 and 27 micrograms/ml, respectively, with doses of 8.8 and 10.5 mg/kg/d. Both patients also continue to receive valproic acid and a benzodiazepine.
mesh_terms: D000328:Adult; D004831:Epilepsies, Myoclonic / Q000188:drug therapy*; D006801:Humans; D007555:Isoxazoles / Q000627:therapeutic use*; D008297:Male; D010080:Oxazoles / Q000627:therapeutic use*; D000078305:Zonisamide
chemical_list: D007555:Isoxazoles; D010080:Oxazoles; D000078305:Zonisamide