Studies of neurocirculatory effects of long-term L-threo-3,4-dihydroxyphenylserine administration in a patient with familial amyloidotic polyneuropathy.
The case is reported of a 57-year-old woman with familial amyloidotic polyneuropathy and concomitant orthostatic hypotension for which L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) was clinically effective. Testing of autonomic function under telemetric intra-arterial pressure monitoring before and during L-threo-DOPS treatment clearly demonstrated the pathophysiology of the sympathetic nervous system and its modification by L-threo-DOPS.
D000686:Amyloidosis / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D001775:Blood Circulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D003243:Consciousness; D015103:Droxidopa / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate; D006801:Humans; D007024:Hypotension, Orthostatic / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D008875:Middle Aged; D009420:Nervous System / Q000187:drug effects* / Q000503:physiopathology; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D012694:Serine / Q000031:analogs & derivatives*
D012694:Serine; D015103:Droxidopa