Amygdaloid catecholaminergic mechanisms involved in suppressive effects of electroconvulsive shock on duration of immobility in rats forced to swim.
Chronic but not acute treatment with electroconvulsive shock (ECS) significantly reduced the duration of immobility in rats forced to swim. The immobility-reducing effect of chronic treatment with ECS was strongly antagonized by 6-hydroxydopamine but not by 5,7-dihydroxytryptamine given into the medial amygdaloid nucleus. These results indicate that ECS, like the tricyclic antidepressants, reduces the duration of immobility in rats forced to swim and that catecholaminergic mechanisms in the medial amygdaloid nucleus are involved in the suppressive effect of ECS on the duration of immobility, as are the tricyclic antidepressants.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism / Q000502:physiology*; D004597:Electroshock; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming
D002395:Catecholamines; D006892:Hydroxydopamines; D015116:5,7-Dihydroxytryptamine; D016627:Oxidopamine