Articular ossification after malignant neurolepsis. A case of schizophrenia treated with phenothiazines.
Following administration of phenothiazines for schizophrenia, a 25-year-old patient developed a malignant neuroleptic syndrome followed by bilateral periarticular ossification of the knees, with severely limited motion. Two years later, the patient regained useful motion after bilateral excision of the ossified tissue and intensive physiotherapy. No recurrence of ossification was observed 3 years after operation, and the patient has maintained almost normal motion.
D000328:Adult; D005500:Follow-Up Studies; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008728:Methotrimeprazine / Q000008:administration & dosage / Q000009:adverse effects*; D009068:Movement; D009459:Neuroleptic Malignant Syndrome / Q000150:complications* / Q000209:etiology; D009999:Ossification, Heterotopic / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D012562:Schizophrenia, Disorganized / Q000188:drug therapy*; D013997:Time Factors
D008728:Methotrimeprazine