Relations between GABAergic and enkephalinergic systems: effects of sodium valproate on rat brain enkephalins.
The acute effects of a Gaba-mimetic drug, Sodium Valproate, are studied on brain enkephalin contents in rat brain. Valproate administered at both 300 and 600 mg/kg doses induces an increase of enkephalin levels in striatum, hypothalamus, brain stem and cortex. No effect is seen in the hypophysis.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004745:Enkephalins / Q000378:metabolism*; D008297:Male; D008959:Models, Neurological; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D014635:Valproic Acid / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D004745:Enkephalins; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid