[Topography of P300 in psychiatry--II. Cognitive P300 fields in dementia].
The P300 wave undergoes alterations during physiological aging showing lower amplitudes and longer latencies in geriatric controls. By means of topographical display of P300-data it could be shown that the topography with maximal positivity at parietal sites is maintained in aging. In patients, however, suffering from senile dementia of Alzheimer's type signs of a frontal elevation and a parietal decrement of P300 amplitudes could be observed. The findings can be interpreted firstly as an indication that the frontal lobe is less effected. On the other side if a hippocampal dipole is assumed a neuronal lesion could lead to a turn of this dipole with the result of a now frontally located positivity.
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000503:physiopathology; D003072:Cognition Disorders / Q000503:physiopathology*; D003704:Dementia / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory; D006801:Humans; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D012815:Signal Processing, Computer-Assisted
Topographie der P300 in der Psychiatrie--II. Kognitive P300-Felder bei Demenz.