Activity of some naphthoquinones on blood stream forms of Trypanosoma cruzi.
Accidental transmission of Chagas disease to man by blood transfusion is a serious problem in Latin America. This paper describes the testing of several naphthoquinones, some of which were active against blood trypomastigotes in vitro at 4 degrees C and might therefore warrant further study for preventing transmission of Chagas disease by blood transfusion.
D000818:Animals; D001803:Blood Transfusion; D014355:Chagas Disease / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D009285:Naphthoquinones / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014349:Trypanosoma cruzi / Q000187:drug effects*
D009285:Naphthoquinones