Suppression of release of microfilariae in vitro from Setaria cervi (Nematoda: Filariodeae) by chlorpromazine.
Chlorpromazine (CPZ) caused suppression in release of microfilariae in vitro from Setaria cervi at 10(-5) M concentration. The inhibitory effect of CPZ was further stimulated by Ca2+ (2 mM), whereas addition of EGTA (2 mM) resulted in partial reversal. Addition of dopamine (1 mM) along with CPZ (10(-5) M) caused similar inhibition as was observed in the presence of CPZ (10(-5) M) alone. CPZ did not effect in vitro oxygen uptake by worm homogenates up to 0.5 mM concentration. The results indicate the Ca2+/calmodulin-dependent anthelmintic action of CPZ on S. cervi.
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D002147:Calmodulin / Q000037:antagonists & inhibitors / Q000502:physiology; D002746:Chlorpromazine / Q000494:pharmacology*; D004533:Egtazic Acid / Q000494:pharmacology; D005260:Female; D005370:Filarioidea / Q000187:drug effects* / Q000378:metabolism; D008842:Microfilariae / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects
D000871:Anthelmintics; D002147:Calmodulin; D011954:Receptors, Dopamine; D004533:Egtazic Acid; D002118:Calcium; D002746:Chlorpromazine