title: Use of "average of normals" quality control procedure in the detection and resolution of assay discrepancies.
abstract: Improved computer technology and imperatives for cost control have made the use of "average of normals" (AVON) procedure an attractive alternative to the more expensive standard quality control programs for clinical laboratory assay monitoring. The authors report the use of a version of the AVON procedure to resolve assay discrepancies with CO2 determination that the traditional quality control program appeared incapable of detecting. Their study suggests that the mean of patients within the reference interval (RI) is a sensitive indicator of accuracy, whereas the percentage of patients within RI is a good indicator of random imprecision.
mesh_terms: D002245:Carbon Dioxide / Q000097:blood; D002624:Chemistry, Clinical / Q000379:methods*; D009716:Numerical Analysis, Computer-Assisted; D011786:Quality Control; D013223:Statistics as Topic
chemical_list: D002245:Carbon Dioxide