Insulin and acivicin improve host nutrition and prevent tumor growth during total parenteral nutrition.
The effect that a 14-day treatment program of total parenteral nutrition (TPN) combined with the glutamine antimetabolite, acivicin, and anabolic hormone, insulin, has on carcass weight and muscle sparing was investigated in tumor-bearing rats. Although TPN resulted in increased carcass weight gain as compared to chow-fed tumor-bearing rats, no savings in gastrocnemius muscle could be demonstrated. The combination of TPN with daily insulin treatment elicited significant increases in both carcass weight and muscle savings, with no alteration in tumor growth. Although combining acivicin with TPN halted tumor growth and increased carcass weight, the change in carcass weight was less than that observed with the insulin-TPN combination. No muscle savings were observed in the acivicin-TPN-treated rats. Yet when acivicin and insulin were combined with TPN, tumor growth was stopped, carcass weight was gained, and muscle mass was saved. Therefore, these experiments suggest that it is possible to add lean body tissue and stabilize tumor growth in rats that receive TPN through anabolic hormone treatment combined with an inhibitor of tumor metabolism.
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology*; D007555:Isoxazoles / Q000494:pharmacology*; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism; D009132:Muscles / Q000473:pathology; D009929:Organ Size; D010080:Oxazoles / Q000494:pharmacology*; D010289:Parenteral Nutrition, Total; D051381:Rats; D011916:Rats, Inbred F344; D012513:Sarcoma, Experimental / Q000473:pathology*
D000963:Antimetabolites; D007328:Insulin; D007555:Isoxazoles; D009124:Muscle Proteins; D010080:Oxazoles; C006303:acivicin