Effect of hydroxyurea on the concanavalin-A proliferative response of Trypanosoma cruzi infected mice.
Mice infected with Trypanosoma cruzi develop immunosuppression with a deficient production of interleukin-2 (IL-2). In this situation the deficient concanavalin A (Con A) T-cell response is not corrected by addition of exogenous IL-2. Here we show that elimination of cycling cells by treatment of infected mice with hydroxyurea (HU) fully restored the ability of spleen cells to respond to IL-2. Further, capacity for IL-2 production was restored to HU treated infected mice, but not as completely as the response to IL-2.
D000818:Animals; D014355:Chagas Disease / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006918:Hydroxyurea / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D007376:Interleukin-2; D003208:Concanavalin A; D006918:Hydroxyurea