The effect of granulocyte factor (GF) on the production of interleukins and Tac antigen expression.
In the course of adherence granulocytes secrete the granulocyte factor (GF) which modifies lymphocyte functions in vitro. GF augments the interleukins production and diminishes mitogen induced Tac antigen expression in vitro, which may result in diminished IL-2 utilization. Consequently, such cells probably do not absorb IL-2 and do not exert their "inhibitory" potency measured in two step culture. The presented data show a relative deficit in interleukin generation in RA patients and have suggested the role of granulocytes in immunoregulation presumably in the course of diseases accompanied by inflammatory processes.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D007378:Interleukins / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology; D009000:Monocytes / Q000276:immunology; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2
D007375:Interleukin-1; D007376:Interleukin-2; D007378:Interleukins; D008934:Mitogens; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2