title: Modulation of arachidonic acid metabolism in experimental arthritis induced by Salmonella enteritidis. I. Effect of ibuprofen and flurbiprofen on experimental arthritis induced by Salmonella enteritidis.
abstract: Oral administration of two nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, can suppress the Salmonella-induced arthritis in rats. The joint swelling index of arthritic paws showed suppression of arthritis in animals treated with the drugs, this effect being greater with flurbiprofen. Measurement of 5 eicosanoids in femoral vein plasma showed increase of arachidonic acid products in Salmonella-treated rats. Inhibition of joint inflammation resulting from treatment with ibuprofen and flurbiprofen is reflected by a decrease in concentration of all 5 eicosanoids which were found in the order: PGE2 greater than TXB2 greater than 6-keto-PGF1 alpha greater than PGF1 greater than PGF2 alpha. These studies indicate that flurbiprofen is a more powerful anti-inflammatory agent than ibuprofen. However, since the joint disease was not completely cured, optimal intervention is quite likely to require modulation of the lipoxygenase pathway.
mesh_terms: D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D001170:Arthritis, Infectious / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D005480:Flurbiprofen / Q000627:therapeutic use*; D007052:Ibuprofen / Q000627:therapeutic use*; D008297:Male; D011422:Propionates / Q000627:therapeutic use*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012480:Salmonella Infections / Q000150:complications / Q000378:metabolism*; D012477:Salmonella enteritidis
chemical_list: D001095:Arachidonic Acids; D011422:Propionates; D016718:Arachidonic Acid; D005480:Flurbiprofen; D011451:Prostaglandin-Endoperoxide Synthases; D007052:Ibuprofen