Effect of terfenadine and ranitidine on histamine and suxamethonium wheals.
The effects of the H-1 receptor blocker terfenadine and the H-2 receptor blocker ranitidine have been experimentally tested in wheals induced with histamine and suxamethonium chloride. Ranitidine alone in the standard and a four-fold higher dose did not notably reduce the size of the wheal and flare as compared to placebo. As expected, both parameters were markedly reduced by the H-1 antihistamine terfenadine in full and half-dosage. A combination of the two drugs both in "standard" and modified dosage resulted in the greatest reduction in the wheal and flare. Histamine and suxamethonium-induced wheals reacted in a similar manner to the antihistamines.
D000293:Adolescent; D000328:Adult; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006632:Histamine; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D011899:Ranitidine / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects; D013390:Succinylcholine; D016593:Terfenadine; D014581:Urticaria / Q000188:drug therapy*
D001559:Benzhydryl Compounds; D016593:Terfenadine; D006632:Histamine; D011899:Ranitidine; D013390:Succinylcholine