Inhibition of affective aggression and dominance in rats after thyrotropin-releasing hormone (TRH) microinjection into the nucleus accumbens.
The effect of 10 micrograms TRH injected bilaterally into the nucleus accumbens septi on two models of affective aggression and on dominance in a water-competition task was investigated in pairs of male Wistar rats. TRH significantly suppressed affective shock-induced and apomorphine-induced fighting. It also decreased dominance when administered to dominant rats while no effect was noted upon injection into subordinate animals. The peptide influenced neither water consumption in thirsty rats nor the pain threshold in a hot plate test.
D000339:Affect; D000374:Aggression / Q000187:drug effects*; D000818:Animals; D008297:Male; D008845:Microinjections; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D010146:Pain / Q000503:physiopathology; D011187:Posture; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000502:physiology*; D012930:Social Dominance; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone