title: In vitro susceptibility of Mycobacterium tuberculosis to ofloxacin and ciprofloxacin in combination with rifampin and isoniazid.
abstract: The in vitro susceptibility of Mycobacterium tuberculosis to new quinolones, ofloxacin and ciprofloxacin, alone and in combination with rifampin or isoniazid, was studied by the agar dilution method. At a concentration of 1 mg/l or lower of ofloxacin and ciprofloxacin, 90% of the strains were inhibited. A synergistic effect with rifampin and with isoniazid was demonstrated.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D004357:Drug Synergism; D007538:Isoniazid / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010078:Oxazines; D002939:Ciprofloxacin; D015242:Ofloxacin; D007538:Isoniazid; D012293:Rifampin