2,5-Hexanedione-induced accumulations of neurofilament-immunoreactive material throughout the rat autonomic nervous system.
In rats intoxicated with 2,5-hexanedione, nerve fibres supplying virtually all visceral organs showed large numbers of densely immunoreactive accumulations of neurofilament-like material, of fusiform, elongated, smoothly tapering morphology. In the gut, round to oval, morphologically different lesions were also present, and abnormal neurofilament-immunoreactive accumulations were revealed in oesophageal terminal end-plates. An extensive damage to autonomic nerve fibres, which are largely non-myelinated, was thus revealed in 2,5-hexanedione intoxication. The observed diversity in lesion morphology may suggest heterogeneity in cytoskeletal and/or associated proteins among autonomic neurons.
D000818:Animals; D001341:Autonomic Nervous System / Q000276:immunology* / Q000473:pathology; D004947:Esophagus / Q000294:innervation; D006588:Hexanones / Q000494:pharmacology* / Q000506:poisoning; D007120:Immunochemistry; D007381:Intermediate Filament Proteins / Q000276:immunology*; D007422:Intestines / Q000294:innervation; D007659:Ketones / Q000494:pharmacology*; D008297:Male; D009412:Nerve Fibers / Q000276:immunology / Q000473:pathology; D016900:Neurofilament Proteins; D051381:Rats; D011919:Rats, Inbred Strains; D014781:Viscera / Q000294:innervation
D006588:Hexanones; D007381:Intermediate Filament Proteins; D007659:Ketones; D016900:Neurofilament Proteins; C011269:2,5-hexanedione