Antimycoplasmal activities of the pseudomonic acids and structure-activity relationships of monic acid A derivatives.
The antimycoplasmal activities of the pseudomonic acids isolated from Pseudomonas fluorescens NCIB 10586 are reported. Structure-activity relationships of a variety of ester, amide and thiol ester derivatives of the nucleus, monic acid A, are described. Enhanced antimycoplasmal activity is reported for a number of monic acid A esters and the most potent derivative, m-nitrobenzyl monate A, is a 100-fold more active against Mycoplasma hyopneumoniae than pseudomonic acid A.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D002626:Chemistry, Pharmaceutical; D004952:Esters / Q000494:pharmacology; D005227:Fatty Acids / Q000494:pharmacology; D016712:Mupirocin; D009174:Mycoplasma / Q000187:drug effects; D011714:Pyrans / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D004952:Esters; D005227:Fatty Acids; D011714:Pyrans; C056341:monic acid A; D016712:Mupirocin