Calcium absorption from a new calcium delivery system (CCM).
Absorption of calcium from a highly soluble form of calcium, a mixed calcium citrate-malate salt (CCM), was tested against calcium carbonate and milk in both rats and humans. The rat method estimated absorption from the 6-day retention of an oral tracer, and the human method employed the standard double-isotope procedure. CCM was given both as a dry powder and in an orange juice beverage. In two experiments in rats calcium from CCM was absorbed at least as well as, if not better than from calcium carbonate or milk. In two separate experiments in humans, calcium from CCM was absorbed significantly better than from calcium carbonate or milk. We conclude that CCM exhibits excellent bioavailability and that this formulation is a useful addition to the forms of calcium now available either for direct supplementation or for food fortification.
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D000818:Animals; D001682:Biological Availability; D002118:Calcium / Q000493:pharmacokinetics*; D002119:Calcium Carbonate / Q000008:administration & dosage*; D002132:Calcium Radioisotopes / Q000378:metabolism; D002951:Citrates / Q000008:administration & dosage*; D019343:Citric Acid; D005260:Female; D006801:Humans; D008293:Malates / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002132:Calcium Radioisotopes; D002951:Citrates; D008293:Malates; D019343:Citric Acid; C030298:malic acid; D002119:Calcium Carbonate; D002118:Calcium