title: Non-adenomatous inappropriate TSH hypersecretion and euthyroidism requires no treatment.
abstract: The syndrome of inappropriate TSH secretion is described in a euthyroid girl and her father. Based on nuclear T3 binding studies in fibroblasts, generalized tissue resistance was associated with a lower binding affinity for T3 in nuclear extracts suggestive of a structurally abnormal receptor for T3. Early recognition of the syndrome and observation of the short-term response to thyroid medication prevented unnecessary trials of antithyroid medication and later radical ablative thyroid treatment.
mesh_terms: D002675:Child, Preschool; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D006042:Goiter / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010901:Pituitary Function Tests; D013577:Syndrome; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone; D014284:Triiodothyronine / Q000031:analogs & derivatives / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D013963:Thyroid Hormones; D014284:Triiodothyronine; C010642:3,3',5-triiodothyroacetic acid; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin