[Intensified aggressivity of dominant male mice after the intraventricular administration of 6-hydroxydopamine].
Aggressiveness of dominant male mice of different genotypes was studied after administration of 6-OHDA into the brain lateral ventriculus. Administration of neurotoxine led to lowering of noradrenaline and dopamine level in the brain in the average by 40%. Besides, the aggressiveness of the animals rose and the latency of the first attack shortened, while their rank did not change. Administration of the solvent in analogous conditions influenced neither the rank of the animal nor its aggressiveness. Conclusion is made that catecholamines take part in regulation of aggressiveness of dominant male mice.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000032:analysis; D006892:Hydroxydopamines / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains; D009638:Norepinephrine / Q000032:analysis; D016627:Oxidopamine; D012701:Serotonin / Q000032:analysis; D012930:Social Dominance
D006892:Hydroxydopamines; D012701:Serotonin; D016627:Oxidopamine; D004298:Dopamine; D009638:Norepinephrine
Povyshenie agressivnosti dominantnykh samtsov mysheĭ posle vnutrizheludochkovogo vvedeniia 6-gidroksidofamina.