Nocturnal asthma: effects of slow-release terbutaline on spirometry and arterial blood-gases.
The effect of terbutaline, in a slow-release preparation, on spirometry and arterial blood-gases, was studied in fourteen patients with nocturnal asthma. The patients were treated with either 15 mg of slow-release terbutaline or placebo given as a single dose at 10 pm for eight days in a double-blind crossover trial. The patients were studied in the hospital for one night at the end of each treatment period. During active treatment the patients had a significantly higher FEV1 and PaO2 compared with placebo. Tolerance to the high single dose was good and none of the patients discontinued treatment because of side-effects. In patients with nocturnal asthma treatment with a high dose of slow-release terbutaline given as a single dose in the evening appears to be effective.
D001249:Asthma / Q000188:drug therapy*; D002245:Carbon Dioxide / Q000097:blood; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D013147:Spirometry; D013726:Terbutaline / Q000008:administration & dosage* / Q000627:therapeutic use
D003692:Delayed-Action Preparations; D002245:Carbon Dioxide; D013726:Terbutaline; D010100:Oxygen