Ir gene for bovine insulin in the rat maps to RT1.B beta.
The genetic control of the immune response to bovine insulin (BI) in the rat was investigated. As a result of experiments utilizing two intra-MHC recombinant rats and of blocking experiments with monoclonal antibodies against MHC class II antigens, an immune response gene for BI in the rat could be mapped to the RT1.B beta locus.
D000818:Animals; D002417:Cattle; D005802:Genes, MHC Class II; D005819:Genetic Markers; D006649:Histocompatibility Antigens / Q000235:genetics* / Q000276:immunology; D007328:Insulin / Q000235:genetics* / Q000276:immunology; D008213:Lymphocyte Activation; D051381:Rats; D011919:Rats, Inbred Strains
D005819:Genetic Markers; D006649:Histocompatibility Antigens; D007328:Insulin; C038353:histocompatibility antigens RT, rat