Modification of arachidonic metabolism by flavonoids.
The pharmacological effects of many plants depend on their flavonoid constituents. This review is concerned with the influence of flavonoids on arachidonic metabolism as the possible mechanism of action of such natural products. Special attention has been paid to structure-activity relationships since this knowledge may allow the synthesis of more potent and selective analogs with therapeutic applications.
D000818:Animals; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D005343:Fibrinolytic Agents; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy; D016859:Lipoxygenase Inhibitors; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D001095:Arachidonic Acids; D005343:Fibrinolytic Agents; D005419:Flavonoids; D016859:Lipoxygenase Inhibitors; D016718:Arachidonic Acid; D011451:Prostaglandin-Endoperoxide Synthases