Age-related changes in the response of hepatic succinic dehydrogenase activity to thyroxine and thiourea in lizards.
Intraperitoneal injection of thyroxine (T4; 1 microgram/g body weight on alternate days, seven doses) to male garden lizards of three different age groups caused a stimulation of hepatic succinic dehydrogenase activity, the degree of response being higher in the old (63%) than in middle-aged (39%) and young (31%). Percent inhibition of enzyme activity following thiourea treatment (0.05 mg/g body weight on alternate days, three doses) was higher in middle-aged lizards (24%) than in young (10%) and old (12%) ones.
D000367:Age Factors; D000818:Animals; D066298:In Vitro Techniques; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008116:Lizards / Q000378:metabolism*; D008297:Male; D013385:Succinate Dehydrogenase / Q000032:analysis / Q000378:metabolism*; D013890:Thiourea / Q000494:pharmacology*; D013974:Thyroxine / Q000494:pharmacology*
D013385:Succinate Dehydrogenase; D013890:Thiourea; D013974:Thyroxine