[Indices of sympathetic neurocyte transcription and the survival indices of fractionally and partially chemically sympathectomized rats against a background of atsefen use].
Transcription in sympathetic neurocytes of ageing (22 months) normally developing rats, partially sympathectomized by guanethidine, was studied with autoradiography. Beginning with the age of 12 months some experimental animals were given daily dose of 1 mg/ml of geroprotector, atsefen (centrophenoxine), in water solution. The time-course of death rate in animals aged 12-30 months was studied as well. A positive dose-dependent relationship between some ageing symptoms of sympathetic neurocytes of sympathectomized animals and their maximum life span was shown. Geroprotector atsefen were found to inhibit some ageing processes in sympathetic nerve cells, their maximum life span increasing simultaneously.
D000375:Aging / Q000187:drug effects*; D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006016:Glycolates / Q000494:pharmacology*; D006145:Guanethidine; D008136:Longevity / Q000187:drug effects*; D002504:Meclofenoxate / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013563:Sympathectomy, Chemical; D013997:Time Factors; D014158:Transcription, Genetic / Q000187:drug effects*
D006016:Glycolates; D002504:Meclofenoxate; D006145:Guanethidine
Issledovanie pokazateleĭ transkriptsii simpaticheskikh nevrotsitov i pokazateleĭ vyzhivaniia u drobno chastichno khimicheski desimpatizirovannykh krys na fone primeneniia atsefena.