title: Intracellular injection of Ca2+ chelator does not affect spike repolarization of cat spinal motoneurons.
abstract: Both intra- and extracellular injections of tetraethylammonium (TEA) prolonged the spike repolarization of motoneurons in the spinal cord of cats under pentabarbitone anaesthesia, but did not depress the afterhyperpolarization (AHP). Intracellular injections of EGTA and the fast-acting Ca2+ chelator, BAPTA, greatly depressed the AHP, but the spike shape remained unchanged. Extracellular applications of Cd2+ had similar effects. These observations suggest that a Ca2+-dependent K+ outward current is not a major mechanism of spike repolarization in motoneurons.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000502:physiology*; D002415:Cats; D002614:Chelating Agents / Q000494:pharmacology*; D004533:Egtazic Acid / Q000494:pharmacology* / Q000031:analogs & derivatives; D004558:Electric Stimulation; D009046:Motor Neurons / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
chemical_list: D002614:Chelating Agents; D013757:Tetraethylammonium Compounds; D004533:Egtazic Acid; C025603:1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; D002118:Calcium