Isoniazid and ethambutol as a cause of optic neuropathy.
A well-recognized complication of ethambutol use is optic neuropathy, but the potential ocular toxicity of isoniazid is often overlooked. A patient developed optic neuropathy while being treated with isoniazid and ethambutol. The optic neuropathy subsided only when both drugs were discontinued, suggesting an additive toxic effect.
D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004357:Drug Synergism; D004977:Ethambutol / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D009898:Optic Disk / Q000473:pathology*; D012607:Scotoma / Q000139:chemically induced*; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy
D004977:Ethambutol; D007538:Isoniazid