title: Surgical treatment of severe periodontitis in a haemophilic patient with inhibitors to factor VIII. Report of a case.
abstract: This report describes the surgical treatment of advanced periodontitis in a haemophilic patient with inhibitors to Factor VIII. The treatment was performed after substitution therapy with Factor VIII-concentrate, supported by local and systemic antifibrinolytic treatment with tranexamic acid. No complications developed postoperatively, and after 9 months, the patient did not show recurrence of periodontal disease. Although the present case shows, that even severe periodontitis can be treated surgically in haemophilic patients with inhibitors to Factor VIII, this should not be done unless it is absolutely necessary. The treatment of periodontal disease in such patients should be instituted as early as possible in order to prevent the need for extensive surgery or dental extractions.
mesh_terms: D000906:Antibodies / Q000032:analysis*; D005169:Factor VIII / Q000276:immunology*; D006467:Hemophilia A / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000097:blood / Q000601:surgery*; D013524:Surgical Flaps
chemical_list: D000906:Antibodies; D005169:Factor VIII