Cytotoxic activity of leukotoxin, a neutrophil-derived fatty acid epoxide, on cultured human cells.
Leukotoxin (LX: 9,10-epoxy-12-octadecenoate) which was previously found to be biosynthesized by neutrophils, exhibited a dominant cytotoxic activity toward human tumor cells as well as toward normal cells. At the concentration of 50-100 micrograms LX/ml cell culture medium, LX completely blocked the growth of the cells of several transformed cell lines (HeLa, Hep-2, MG-63, Chang liver, Wish, FL-Amnion) as well as the normal (Flow 2000 and Flow 13000). From the results, a part of inhibition of tumor growth by neutrophils can be attributed to LX.
D003602:Cytotoxicity, Immunologic; D006801:Humans; D008041:Linoleic Acids / Q000494:pharmacology*; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D014118:Toxins, Biological / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000276:immunology
D008041:Linoleic Acids; D008937:Mitomycins; D014118:Toxins, Biological; D016685:Mitomycin; C051208:9,10-epoxy-12-octadecenoic acid