Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro.
The effects of several benzodiazepines (diazepam, clonazepam, Ro 15-1788 and Ro 5-4864) on cell proliferation of 2 human gliomas were estimated in vitro by means of [3H]-thymidine uptake assay. It was found that all tested benzodiazepines suppressed [3H]-thymidine incorporation into the DNA of glioma cells, the effects being stronger in case of peripheral-type benzodiazepine receptor ligands. The results indicated that benzodiazepines might exert an antiproliferative action on glioma tumour cells growth.
D001254:Astrocytoma; D001569:Benzodiazepines / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002998:Clonazepam / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D005260:Female; D005442:Flumazenil / Q000494:pharmacology; D005910:Glioma; D006801:Humans; D008297:Male; D008875:Middle Aged; D013936:Thymidine; D014407:Tumor Cells, Cultured / Q000166:cytology* / Q000187:drug effects
D001570:Benzodiazepinones; D001569:Benzodiazepines; C028513:4'-chlorodiazepam; D005442:Flumazenil; D002998:Clonazepam; D003975:Diazepam; D013936:Thymidine