Modulation of chemical carcinogenesis in rats by alkyl lysophospholipids.
The influence of 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) and 1-hexadecylmercapto-2-methoxymethyl-rac-propyl-3-phosphocholine (TLP, BM41.440) on methylnitrosourea (MNU)-induced rat mammary carcinomas and of ET-18-OCH3 on 7,12-dimethylbenzanthracene (DMBA)-induced leukemias was investigated. Both agents effectively delayed MNU-induced mammary tumor formation at high, cytotoxic dosages but TLP had no influence at low "immunomodulatory" doses. ET-18-OCH3 also significantly protected against leukemia development in DMBA-treated Long-Evans rats.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007942:Leukemia, Experimental / Q000139:chemically induced / Q000188:drug therapy; D008246:Lysophospholipids / Q000627:therapeutic use*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy; D008770:Methylnitrosourea; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000188:drug therapy; D010755:Organophosphates / Q000627:therapeutic use*; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D010742:Phospholipid Ethers / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents; D008246:Lysophospholipids; D010755:Organophosphates; D009943:Organophosphorus Compounds; D010742:Phospholipid Ethers; C026659:edelfosine; D015127:9,10-Dimethyl-1,2-benzanthracene; C043297:ilmofosine; D008770:Methylnitrosourea