title: Effect of occlusal (mechanical) stimulus on bone remodelling in rat mandibular condyle.
abstract: Mechanical load influences the remodelling of skeletal tissues. In the mandibular condyle, occlusal alterations and the consequent mechanical stimulus induce changes in chondrocytes and cartilage mineralization. In the present study we quantified in the mandibular condyle the effect of occlusal interference on remodelling of the subchondral bone. Computerized histomorphometry after 5-21-day exposure to the influence of a unilateral occlusal splint revealed an increased rate of trabecular remodelling, consisting of enhancement in osteoblast and osteoclast numbers and activities. The bone formation parameters reached their high values on Days 5 or 9 and remained stable thereafter. Bone resorption showed a gradual increase throughout the experimental period. These results further characterize the temporomandibular joint reaction to occlusal alterations. It is suggested that the present increase in bone turnover together with the known enhancement in chondrogenesis are part of a process of functional adaptation in response to mechanical stimulus.
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000473:pathology / Q000503:physiopathology; D002356:Cartilage / Q000473:pathology / Q000503:physiopathology*; D003769:Dental Occlusion, Traumatic / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008335:Mandibular Condyle / Q000473:pathology / Q000503:physiopathology*; D010012:Osteogenesis; D051381:Rats; D011919:Rats, Inbred Strains; D013314:Stress, Mechanical; D013997:Time Factors