Amygdala kindling and c-fos protein(s).
c-fos protein was visualized immunohistochemically in the brains of rats after partial amygdala seizures and generalized amygdala-kindled seizures and in seizure-free amygdala-kindled rats. Four hours following partial amygdala seizures there was a massive induction of c-fos protein in the ipsilateral piriform cortex, entorhinal cortex, and amygdala. Following generalized amygdala-kindled seizures there was a massive bilateral induction of c-fos in the entire cerebral cortex, amygdala, piriform and entorhinal cortices, hippocampus, and dentate gyrus. However, there did not appear to be any change in the basal levels of c-fos in the brains of amygdala-kindled rats that had been seizure free for 7 days. These results show that kindled seizures induce c-fos in neurons, but that the permanence of kindling is not related to altered basal c-fos levels.
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000378:metabolism; D004569:Electroencephalography; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology; D007696:Kindling, Neurologic; D008297:Male; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D014018:Tissue Distribution
D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos