L-dihydroxyphenylalanine-induced asymmetric changes in striatal uric acid peak: determination by in vivo electrochemical detection in rats with unilateral nigrostriatal lesions.
Rats were unilaterally lesioned with 6-hydroxydopamine to destroy the nigrostriatal pathway. Following injection with 25 mg/kg L-dopa, circling behavior away from the lesioned side was monitored. Concurrently, in vivo electrochemical detection was used to compare changes in striatal extracellular levels of ascorbic acid (Peak 1) and uric acid (Peak 2) on the lesioned and unlesioned sides. Peak 1 changes did not differ, but Peak 2 changed asymmetrically on the two sides. The difference in the changes in Peak 2 was highly correlated with the circling behavior, with the greater increase on the lesioned side.
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D001522:Behavior, Animal / Q000187:drug effects; D002421:Caudate Nucleus / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004295:Dihydroxyphenylalanine / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D007839:Functional Laterality; D008297:Male; D051381:Rats; D014527:Uric Acid / Q000378:metabolism*
D014527:Uric Acid; D004295:Dihydroxyphenylalanine; D001205:Ascorbic Acid; D004298:Dopamine