Extra-pituitary action of luteinizing hormone releasing hormone on intraocular pressure.
Luteinizing hormone releasing hormone (LHRH) given intraventricularly caused a delayed, significant decrease of intraocular pressure (IOP) in adult female rabbits for a prolonged period, but only elevated plasma gonadotropins for a few hrs. Intravenous injections of LHRH caused a similar elevation of plasma gonadotropins without any effect on IOP. It indicates that LHRH initiates a mechanism in the central nervous system to decrease IOP, which is unrelated to the conventional LHRH-gonadotropin axis.
D000818:Animals; D002552:Cerebral Ventricles / Q000502:physiology; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000097:blood / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000097:blood; D010477:Perfusion; D013997:Time Factors
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone