Action of forskolin on non-electrolyte permeability across the urinary bladder of Bufo bufo as compared to that of various hormones.
1. Forskolin, an activator of adenyl-cyclase in a receptor-independent manner, mimics the ADH effect on the urea and thiourea permeabilities across the toad bladder. 2. However, differently from ADH, forskolin increases the erythritol permeability across the tissue and this effect is not reproduced by two substances increasing the urea permeability (8-BrcAMP and isoprenaline). Most probably this effect of forskolin does not involve the cAMP generating system.
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D000818:Animals; D002023:Bufo bufo; D002463:Cell Membrane Permeability / Q000187:drug effects; D005576:Colforsin / Q000494:pharmacology*; D004896:Erythritol / Q000378:metabolism; D006728:Hormones / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D014508:Urea / Q000378:metabolism; D001743:Urinary Bladder / Q000378:metabolism*
D006728:Hormones; D005576:Colforsin; D015124:8-Bromo Cyclic Adenosine Monophosphate; D014508:Urea; D007545:Isoproterenol; D004896:Erythritol