title: Plasmapheresis, a treatment modality for necrobiotic xanthogranuloma.
abstract: A case of necrobiotic xanthogranuloma treated with plasmapheresis is reported. This entity is characterized by multiple inflammatory, ulcerative nodules and atrophic plaques with a xanthomatous quality that develop in conjunction with a paraproteinemia. Successful healing of ulcerated lesions and lowering of the paraproteinemia was achieved by plasmapheresis in our patient with necrobiotic xanthogranuloma when cytotoxic therapy failed.
mesh_terms: D005260:Female; D006099:Granuloma / Q000150:complications / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D008875:Middle Aged; D009336:Necrosis; D010265:Paraproteinemias / Q000150:complications / Q000276:immunology / Q000628:therapy; D010956:Plasmapheresis; D014973:Xanthomatosis / Q000150:complications / Q000276:immunology / Q000628:therapy*
chemical_list: D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains