Suppression of the chloroquine resistance of Plasmodium berghei by treatment of infected mice with a microsomal monooxygenase inhibitor.
Administration of a combination of chloroquine and the copper-lysine complex, copper(lysine)(2), an inhibitor of microsomal monooxygenases, considerably decreased the parasitaemia level of mice infected with a chloroquine-resistant strain of Plasmodium berghei. When given separately, chloroquine and the complex had no antimalarial effect. Use of a combination of monooxygenase inhibitors and chloroquine therefore appears to be a promising addendum to the chemotherapy of malaria caused by chloroquine-resistant parasites.
D000818:Animals; D002738:Chloroquine / Q000627:therapeutic use*; D003300:Copper / Q000627:therapeutic use*; D065607:Cytochrome P-450 Enzyme Inhibitors; D004351:Drug Resistance; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D008239:Lysine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010962:Plasmodium berghei / Q000201:enzymology
D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; C053976:copper-lysine complex; D003300:Copper; D002738:Chloroquine; D008239:Lysine