[Effect of the intracisternal administration of the neurotoxins 6-hydroxydopamine and 5,7-dihydroxytryptamine on the formation of the passive avoidance reaction and the biogenic amine level in the brain of rats].
In Wistar rats, intracisternal administration of 6-hydroxydopamine caused a 3.0-3.5-fold decrease in noradrenaline and dopamine levels whereas 5,7-dihydroxytryptamine led to a 2.5-fold reduction of the serotonin content in the hypothalamus. The degeneration of serotoninergic neurons produced by 5,7-dihydroxytryptamine did not affect passive avoidance response while the lesion of catecholaminergic neurons with 6-hydroxydopamine disturbed it. Participation of the brain monoaminergic system in the mechanisms of conditioning is discussed.
D015116:5,7-Dihydroxytryptamine / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001679:Biogenic Amines / Q000032:analysis*; D001923:Brain Chemistry / Q000187:drug effects*; D002946:Cisterna Magna; D003214:Conditioning, Classical / Q000187:drug effects; D004102:Dihydroxytryptamines / Q000008:administration & dosage*; D006892:Hydroxydopamines / Q000008:administration & dosage* / Q000494:pharmacology; D007031:Hypothalamus / Q000032:analysis / Q000187:drug effects; D007267:Injections; D008297:Male; D009498:Neurotoxins; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains
D001679:Biogenic Amines; D004102:Dihydroxytryptamines; D006892:Hydroxydopamines; D009498:Neurotoxins; D015116:5,7-Dihydroxytryptamine; D016627:Oxidopamine
Vliianie vnutritsisternal'nogo vvedeniia neĭrotoksinov 6-oksidofamina i 5,7-dioksitriptamina na formirovanie reaktsii passivnogo izbeganiia i uroven' biogennykh aminov v mozge krys.