title: Development of acidosis in human beings during closed-chest and open-chest CPR.
abstract: We studied the development of acidosis, as measured by blood gases, in a convenience sample of 16 patients undergoing five minutes of closed-chest CPR (CC-CPR) followed by five minutes of open-chest CPR (OC-CPR). To eliminate the influence of variable pCO2 on serum pH, all blood gas values were adjusted to a pCO2 of 40 mm Hg. Adjusted pH fell a mean of 0.09 U (SEM +/- 0.03, P = .02) with five minutes of CC-CPR and then 0.05 U (SEM +/- 0.02, P = .05) with five minutes of OC-CPR. The decline in adjusted pH during CC-CPR was statistically comparable to the decline that occurred during OC-CPR. The development of acidosis as measured by blood gases does not appear to be significantly different for patients undergoing five minutes of CC-CPR versus five minutes of OC-CPR when OC-CPR follows CC-CPR.
mesh_terms: D000138:Acidosis / Q000097:blood* / Q000209:etiology; D000328:Adult; D000368:Aged; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D006323:Heart Arrest / Q000150:complications / Q000628:therapy; D006336:Heart Massage / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D013908:Thoracotomy; D013997:Time Factors
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen