Aberrant production of leukotriene C4 by macrophages from autoimmune-prone mice.
Eicosanoids have been implicated in the pathogenesis of autoimmune diseases. In this study, peritoneal macrophages from autoimmune-prone mice were examined for their capacity to produce proinflammatory 5-lipoxygenase metabolites. The results indicate that enhanced production of leukotriene C4 is a common feature of murine autoimmunity and suggest further that aberrations in 5-lipoxygenase activity may play a role in the development of lupus.
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D002478:Cells, Cultured; D008084:Lipoxygenase / Q000378:metabolism; D008264:Macrophages / Q000201:enzymology / Q000276:immunology*; D051379:Mice; D008817:Mice, Mutant Strains; D013189:SRS-A / Q000096:biosynthesis*
D013189:SRS-A; D008084:Lipoxygenase