A factor from endothelium facilitates activation of plasminogen by tissue plasminogen activator.
A component extracted from endothelium and partially purified has been found to have a capacity to enhance the rate of plasminogen activation by tissue-type plasminogen activator. The mechanism of action of this cofactor differs from that of others, such as fibrin.
D000818:Animals; D004730:Endothelium, Vascular / Q000502:physiology*; D010960:Plasminogen Activators / Q000494:pharmacology*; D013552:Swine; D010959:Tissue Plasminogen Activator / Q000494:pharmacology*
D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator