title: Template-directed oligomerization of 3-isoadenosine 5'-phosphate.
abstract: Template-directed oligomerization of an activated derivative of 3-isoadenosine 5'-phosphate (piA) on polyuridylic acid [poly(U)] was studied. The reaction of ImpiA is more efficient than the corresponding reaction of ImpA, and produces 3'-5'-linked oligomers while the reaction of ImpA gives only 2'-5'-linked oligomers. The base pairing between piA and poly(U) in this system is probably of the Hoogsteen type (involving the 6-amino group and N7 of 3-isoadenosine) rather than of the Watson-Crick type.
mesh_terms: D000249:Adenosine Monophosphate; D002851:Chromatography, High Pressure Liquid; D007202:Indicators and Reagents; D009843:Oligoribonucleotides; D013698:Templates, Genetic
chemical_list: C018354:(2'-5')oligoisoadenylate; D007202:Indicators and Reagents; D009843:Oligoribonucleotides; C056927:3-isoadenosine 5'-phosphate; D000249:Adenosine Monophosphate