Anticonvulsant effect of denzimol in DBA/2 mice.
The anticonvulsant activity of N-[beta-[4-beta-phenylethyl)phenyl]-beta-hydroxyethyl]-imidazole hydrochloride, denzimol, was studied following intraperitoneal administration in DBA/2 mice (seizures induced by sound). Protection against sound-induced seizures was observed after intraperitoneal administration of denzimol (3-15 mg/kg). The ED50 values for the suppression of tonic, clonic and wild running phases of sound-induced seizures were 1.24, 2.61 and 6.03 mg/kg, respectively. This protective action was significantly reduced by pretreatment with aminophylline (25 mg/kg i.p.), CGS 8216 (1 or 5 mg/kg i.p.) and Ro 15-1788 (2.5 mg/kg i.p). The present experiments suggest an involvement of purinergic and benzodiazepine mechanisms in the anticonvulsant action of denzimol.
D000161:Acoustic Stimulation; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D005442:Flumazenil / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D051379:Mice; D008811:Mice, Inbred DBA; D011720:Pyrazoles / Q000494:pharmacology; D012640:Seizures / Q000517:prevention & control
D000927:Anticonvulsants; D007093:Imidazoles; D011720:Pyrazoles; D000628:Aminophylline; D005442:Flumazenil; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one; C031307:denzimol