Side-effects and patient acceptance of 0.2% versus 0.1% chlorhexidine used as post-operative prophylactic mouthwash.
In a double-blind parallel group study including 30 patients, the side-effects and patient acceptance of chlorhexidine mouthwash 0.2% and 0.1% were studied. Side-effects such as loss of taste, burning sensation of the oral mucosa, subjective dryness of the oral cavity and discoloration of teeth and tongue were encountered. There was no statistically significant difference between the chlorhexidine groups with respect to the frequency of the reported side-effects. However, the taste of chlorhexidine 0.1% was significantly better accepted than chlorhexidine 0.2%. 4 patients discontinued the use of chlorhexidine 0.2% before the end of the trial. The quality of the experienced side-effects was stated by the patients as the reason for the discontinuation of chlorhexidine 0.2%. The present work concludes with the recommendation of chlorhexidine 0.1% compared to chlorhexidine 0.2% as a prophylactic mouthwash after oral surgical interventions.
D000328:Adult; D000368:Aged; D002710:Chlorhexidine / Q000008:administration & dosage / Q000009:adverse effects*; D003258:Consumer Behavior; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000009:adverse effects*; D010045:Outpatients; D011182:Postoperative Care; D013649:Taste / Q000187:drug effects
D009067:Mouthwashes; D002710:Chlorhexidine