title: Effects of hydrogen chloride on respiratory response and pulmonary function of the baboon.
abstract: The effects of hydrogen chloride (HCI) inhalation on respiratory response during exposure and on pulmonary function during the 3 mo following exposure were studied in the baboon. Each of 4 groups of three anesthetized animals was exposed in a head-only mode for 15 min to air or one of three HCI concentrations (500, 5000, or 10,000 ppm). The acute respiratory response consisted of a concentration-related increase in frequency and minute volume, with a marked decrease in blood PaO2 at the two highest concentrations. The exposures did not cause significant alterations in any of the pulmonary function parameters measured at 3 d and 3 mo postexposure. Thus, nonhuman primates were able to survive short exposures to high concentrations of HCI without any significant effects on pulmonary function during the 3 mo after exposure. Furthermore, comparison of the response of primates and rodents suggests that the human is much less sensitive to the effects of HCI than the mouse.
mesh_terms: D000818:Animals; D001273:Atmosphere Exposure Chambers; D002245:Carbon Dioxide / Q000097:blood; D006851:Hydrochloric Acid / Q000633:toxicity*; D008168:Lung / Q000187:drug effects*; D008297:Male; D010100:Oxygen / Q000097:blood; D010215:Papio; D013990:Tidal Volume
chemical_list: D002245:Carbon Dioxide; D006851:Hydrochloric Acid; D010100:Oxygen