Pure FSH induces ovulation in polycystic ovary syndrome despite rising androgen levels.
Five patients with carefully defined polycystic ovarian disease (PCOS) were treated with pure follicle stimulating hormone (FSH) to induce ovulation. Serum levels of androstenedione and testosterone were measured daily and noted to rise dramatically, reaching a maximum at the time of ovulation. However, despite the rise in androgens, ovulation occurred in each case and three patients conceived. Contrary to the traditional concept, it is concluded that elevated androgen levels in patients with PCOS do not interfere with ovulation induction using pure FSH.
D000728:Androgens / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D005260:Female; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy; D007273:Injections, Intramuscular; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000628:therapy*
D000728:Androgens; D006063:Chorionic Gonadotropin; D005640:Follicle Stimulating Hormone