title: Active transport of urea by mammalian kidney.
abstract: With the aid of three basic organic compounds, 2-pyrazinoylguanidine, 3-amino-2-pyrazinoylguanidine, and 3,5-diamino-6-fluoro-2-pyrazinoylguanidine, urea was shown to be secreted by the renal tubules of the dog both from the lumen and into the lumen independent of urine flow.
mesh_terms: D000584:Amiloride / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001693:Biological Transport, Active; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D006146:Guanidines / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism*; D008353:Mannitol / Q000494:pharmacology; D011719:Pyrazines / Q000494:pharmacology*; D014508:Urea / Q000378:metabolism*
chemical_list: D006146:Guanidines; D011719:Pyrazines; C056106:3-amino-2-pyrazinoylguanidine; D008353:Mannitol; C056104:2-pyrazinoylguanidine; C056107:3,5-diamino-6-fluoro-2-pyrazinoylguanidine; D000584:Amiloride; D014508:Urea