Suppression of mitomycin C-induced micronuclei in mouse bone marrow cells by post-treatment with vanillin.
Induction of micronuclei by mitomycin C (MMC) in mouse bone marrow cells was suppressed by post-treatment with vanillin, a component of vanilla essence flavour. Vanillin was given orally to mice 7.5 h after intraperitoneal injection of 2 mg/kg MMC. Post-treatment with vanillin at 500 mg/kg caused about 50% decrease in the frequency of micronucleated polychromatic erythrocytes (MN-PCEs). The effect of vanillin administration on the time-course of formation of MN-PCEs was also investigated. The suppressing effect was not due to a delay in the formation of MN-PCEs by the cytotoxic action of vanillin. Vanillin acts as an anticlastogenic factor in vivo.
D000818:Animals; D001547:Benzaldehydes / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects*; D002467:Cell Nucleus / Q000187:drug effects; D002869:Chromosome Aberrations; D051379:Mice; D008815:Mice, Inbred Strains; D016685:Mitomycin; D008937:Mitomycins / Q000037:antagonists & inhibitors*; D009154:Mutation / Q000187:drug effects*
D001547:Benzaldehydes; D008937:Mitomycins; D016685:Mitomycin; C100058:vanillin