title: Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha.
abstract: The nucleotide sequence of human Go alpha was determined from a partial human brain cDNA clone and the sequence of the first two 5' coding exons of a human genomic Go alpha clone. Comparison of this sequence with bovine and rat Go alpha shows greater than 90% homology at the nucleotide and deduced amino acid level. There is 100% identity at the amino acid level for the cholera and pertussis toxin-catalyzed ADP ribosylation sites, the putative guanine nucleotide binding, and the GTP hydrolysis sites.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism; D002417:Cattle; D003001:Cloning, Molecular; D003062:Codon; D004247:DNA / Q000235:genetics; D005091:Exons; D019204:GTP-Binding Proteins / Q000235:genetics*; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats; D013045:Species Specificity
chemical_list: D003062:Codon; D004247:DNA; D019204:GTP-Binding Proteins