IgM binding to sialosyllactosaminylparagloboside in a patient with polyradiculoneuropathy due to Mycoplasma pneumoniae infection.
IgM in serum without paraprotein in a patient with polyradiculoneuropathy due to a Mycoplasma pneumoniae infection reacted specifically with a ganglioside, sialosyllactosaminylparagroboside (SLPG), in a human peripheral nerve on a thin-layer chromatogram plate by an immunostaining technique. This finding suggests the possibility that anti-SLPG antibody in the patient's serum may play a role in the pathogenesis of neuropathy.
D005260:Female; D005732:Gangliosides / Q000378:metabolism; D005915:Globosides / Q000378:metabolism*; D006028:Glycosphingolipids / Q000378:metabolism*; D006801:Humans; D007148:Immunoglobulin mu-Chains / Q000097:blood*; D008875:Middle Aged; D011019:Pneumonia, Mycoplasma / Q000150:complications*; D011129:Polyradiculoneuropathy / Q000209:etiology / Q000276:immunology* / Q000382:microbiology
D005732:Gangliosides; D005915:Globosides; D006028:Glycosphingolipids; D007148:Immunoglobulin mu-Chains; C051587:sialosyllactosaminylparagloboside