title: Treating cocaine abusing methadone maintenance patients with desipramine.
abstract: Intravenous cocaine use in methadone patients has become a major problem because of both the complications of cocaine use and the potential spread of AIDS. During an eight week open trial we found that desipramine reduced cocaine craving and use in eight cocaine abusing methadone maintenance patients compared to eight patients getting no medication execept methadone.
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000635:transmission; D000328:Adult; D003042:Cocaine; D003891:Desipramine / Q000627:therapeutic use*; D005260:Female; D006556:Heroin Dependence / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D008875:Middle Aged; D019966:Substance-Related Disorders / Q000188:drug therapy*
chemical_list: D003042:Cocaine; D003891:Desipramine; D008691:Methadone