Donor bone marrow response to immunosuppressive treatment.
An 8-year-old male with idiopathic severe aplastic anemia was successfully treated with allogeneic bone marrow transplantation in June 1980. However, he had a severe aplastic recurrence on the donor marrow after 3 years of sustained and complete engraftment. An alternative immunosuppressive treatment was attempted as a second bone marrow transplantation could not be performed. Consecutive immunosuppressive courses with antithymocyte globulin, antithymocyte globulin plus ciclosporin A and ciclosporin A alone elicited good but transient responses. At present he needs uninterrupted ciclosporin A treatment to maintain normal donor hemopoiesis. An immune-related and persisting pathogeneic mechanism for the aplasia is suspected that responds to diverse and continuous immunosuppression.
D000741:Anemia, Aplastic / Q000188:drug therapy / Q000628:therapy*; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002648:Child; D003524:Cyclosporins / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D012008:Recurrence; D014019:Tissue Donors; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D003524:Cyclosporins; D007166:Immunosuppressive Agents