Levels of cofactors for lipoprotein lipase and lecithin-cholesterol acyltransferase in plasma patients with severe thermal injury.
Transient hypertriglyceridemia occurs in patients with severe thermal injury, and some patients have a low clearance of exogenous triglyceride (TG) from plasma. This suggests an impaired lipolysis. In the current study, we measured the levels of apolipoproteins required for clearance of endogenous and/or exogenous TG. Twenty-five thermal injury patients (18 men and 7 women) having an average of 52% +/- 6% (SE) total burn surface area were followed for a period of nine weeks. The levels of plasma lipids and apolipoproteins C-II, C-III, E, and A-I were measured after a 12-hour "fast," ie, prior to the parenteral administration of fat emulsion. The levels of plasma cholesterol and apolipoproteins C-II, C-III, and A-I were low. Plasma TG levels, however, were not abnormally elevated, while apo E levels were within normal range. The results indicate that thermally injured patients have reduced levels of apoproteins necessary for TG metabolism. This condition may predispose to intolerance of exogenous TG.
D000328:Adult; D016632:Apolipoprotein A-I; D053304:Apolipoprotein C-II; D053305:Apolipoprotein C-III; D001053:Apolipoproteins / Q000097:blood*; D001054:Apolipoproteins A / Q000097:blood; D001056:Apolipoproteins C / Q000097:blood; D001057:Apolipoproteins E / Q000097:blood; D002056:Burns / Q000097:blood* / Q000628:therapy; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008066:Lipolysis; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008297:Male; D010288:Parenteral Nutrition; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood*
D016632:Apolipoprotein A-I; D053304:Apolipoprotein C-II; D053305:Apolipoprotein C-III; D001053:Apolipoproteins; D001054:Apolipoproteins A; D001056:Apolipoproteins C; D001057:Apolipoproteins E; D005217:Fat Emulsions, Intravenous; D014280:Triglycerides; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D008071:Lipoprotein Lipase