title: Phosphorylase-mediated mobilization of the amino group of adenine in Bacillus cereus.
abstract: Mobilization of the ribose moiety of purine nucleosides as well as of the amino group of adenine may be realized in Bacillus cereus by the concerted action of three enzymes: adenosine phosphorylase, adenosine deaminase, and purine nucleoside phosphorylase. In this pathway, ribose-1-phosphate and inorganic phosphate act catalytically, being continuously regenerated by purine nucleoside phosphorylase and adenosine phosphorylase, respectively. As a result of such a metabolic pathway, adenine is quantitatively converted into hypoxanthine, thus overcoming the lack of adenase in B. cereus.
mesh_terms: D000225:Adenine / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000378:metabolism*; D001409:Bacillus cereus / Q000378:metabolism*; D007288:Inosine / Q000378:metabolism; D009700:Nucleoside Deaminases / Q000378:metabolism*; D011683:Purine-Nucleoside Phosphorylase / Q000378:metabolism; D012267:Ribosemonophosphates / Q000378:metabolism
chemical_list: D012267:Ribosemonophosphates; C031154:ribose 1-phosphate; D007288:Inosine; C019603:adenosine phosphorylase; D011683:Purine-Nucleoside Phosphorylase; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase; D000225:Adenine