C3, Gm, and Pi polymorphisms in rheumatoid arthritis.
This paper reviews the associations between RA and three non-MHS genetic markers: C3, Gm, and Pi. There is no evidence to suggest that genes linked to C3 predispose to RA. However, there is evidence to suggest that genes on chromosome 14, linked to both Gm and Pi, do influence susceptibility to RA and further studies of this chromosome are indicated.
D001172:Arthritis, Rheumatoid / Q000235:genetics*; D003176:Complement C3 / Q000235:genetics*; D004198:Disease Susceptibility; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D000515:alpha 1-Antitrypsin / Q000235:genetics*; D019896:alpha 1-Antitrypsin Deficiency
D003176:Complement C3; D005819:Genetic Markers; D007129:Immunoglobulin Gm Allotypes; D007143:Immunoglobulin Heavy Chains; D000515:alpha 1-Antitrypsin