Factor VIII-related antigen in canine endothelial neoplasms: an immunohistochemical study.
Canine vascular tumors (47 hemangiomas, 36 hemangiosarcomas) were investigated for the endothelial cell marker factor VIII-related antigen (F VIII RAg). The primary antibody was a commercial rabbit anti-human (r/h) F VIII RAg antiserum. All (100%) hemangiomas and 32 (89%) of 36 hemangiosarcomas stained for F VIII RAg. One hemangiosarcoma (3%) was negative, and three tumors (8%) were equivocal in staining. Rarely, the interpretation of stained immature endothelial cells was difficult. The r/h F VIII RAg antibody was a positive marker of normal, reactive, and neoplastic endothelial cells in the dog.
D000818:Animals; D000941:Antigens / Q000032:analysis*; D004283:Dog Diseases / Q000276:immunology* / Q000473:pathology; D004285:Dogs; D004727:Endothelium / Q000032:analysis / Q000473:pathology; D005169:Factor VIII / Q000032:analysis / Q000276:immunology*; D006338:Heart Neoplasms / Q000032:analysis / Q000473:pathology / Q000662:veterinary; D006391:Hemangioma / Q000032:analysis / Q000473:pathology / Q000662:veterinary*; D006394:Hemangiosarcoma / Q000032:analysis / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000032:analysis / Q000473:pathology / Q000662:veterinary; D008113:Liver Neoplasms / Q000032:analysis / Q000473:pathology / Q000662:veterinary; D012878:Skin Neoplasms / Q000032:analysis / Q000473:pathology / Q000662:veterinary; D013160:Splenic Neoplasms / Q000032:analysis / Q000473:pathology / Q000662:veterinary; D014841:von Willebrand Factor
D000941:Antigens; D014841:von Willebrand Factor; D005169:Factor VIII