title: Prevention of progression of Parkinson's disease with antioxidative therapy.
abstract: 1. Oxidative mechanisms in dopaminergic neurons may contribute to cell death and the progression of Parkinson's Disease. 2. The free radical auto-toxicity concept has scientific evidence to support it. 3. Clinical trials are underway to assess the protective effect of augmenting the free radical scavenging system with vitamin E and inhibiting catecholamine oxidation with deprenyl.
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D006801:Humans; D010300:Parkinson Disease / Q000188:drug therapy*; D012642:Selegiline / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D012642:Selegiline