title: Reversal of depressed miduterine arterial flow during hyperthermia-induced respiratory alkalosis.
abstract: The influence of ambient and arterial PCO2 on miduterine arterial flow of pregnant sheep acutely exposed to hot environments was investigated. Five mixed-breed ewes between 120 and 130 days of gestation were subjected to hot environments (increasing from thermoneutral 23 to 40 degrees C), and arterial blood pH, PCO2, and PO2 were determined at 5-min intervals. Respiratory rate, heart rate, rectal temperature, blood pressure, and miduterine arterial flow were continuously monitored prior to and during elevation of ambient air temperature. When miduterine arterial flow had decreased to 50% of thermoneutral control levels, ambient air CO2 was increased to 2.5%. Elevated ambient inspired CO2 caused a reversal in arterial pH and PCO2 to near thermoneutral levels. Miduterine arterial flow increased to 77% of the control levels following the elevated ambient PCO2 period. Respiratory rate also decreased when ambient CO2 was increased but remained 136% greater than the thermoneutral control level. All other parameters remained near their heat stress (40 degrees C) level during the elevation of ambient CO2. These data indicate that heat-stress-induced depression of miduterine arterial flow is vasoactively regulated, and cause-effect related to both arterial pH and PCO2, and thermoregulatory shunting of blood to heat-dissipating surfaces.
mesh_terms: D000472:Alkalosis, Respiratory / Q000503:physiopathology*; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood / Q000494:pharmacology; D005260:Female; D006358:Hot Temperature; D011247:Pregnancy; D012039:Regional Blood Flow; D012119:Respiration; D012756:Sheep; D014599:Uterus / Q000098:blood supply*; D014655:Vascular Resistance
chemical_list: D002245:Carbon Dioxide