title: [Morphologic changes of the small intestine and lymph nodes in alpha-chain disease].
abstract: Literature and original data are reported on a case of alpha-chain disease associated with small intestine lymphoma in a male patient aged 20. The disease manifested clinically with chronic diarrhea, malabsorption, hypoproteinemia, hypocalcemia, cachexia, discretely detected alpha-chain monomer. Morphologically, there was lymphoplasmacyte infiltration of the intestinal mucosal layer; capsule collagenization, clustering immunoblasts among microlymphocytes, a pronounced macrophagal reaction, intercellular crystalloid and lymph masses, follicular pattern disappearance, sites of cellular polymorphism revealed in an axillary lymph node. The latter finding evidenced for developing immunoblastic sarcoma.
mesh_terms: D000328:Adult; D001706:Biopsy; D006801:Humans; D007137:Immunoglobulin alpha-Chains / Q000032:analysis; D007161:Immunoproliferative Small Intestinal Disease / Q000175:diagnosis / Q000473:pathology*; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male
chemical_list: D007137:Immunoglobulin alpha-Chains
vernacular_title: Morfologicheskie izmeneniia tonkoĭ kishki i limfaticheskikh uzlov pri bolezni al'fa-tsepeĭ.