Immunomodulatory effects of staphylococcal lipoteichoic acid in early Listeria monocytogenes infection in Balb/c-mice.
Balb/c-mice were intravenously infected with 5 X 10(4) viable cells of Listeria monocytogenes SLCC 4013. Liver, lung and spleen of the animals showed heavy organ colonization 48 h after infection. Pretreatment of experimental animals with staphylococcal lipoteichoic acid (LTA; 2 mg i.p. 7 and 3 days before challenge) significantly reduced the bacterial count in these organs. In vitro, peritoneal macrophages from LTA-treated mice significantly reduced listerial viability as compared to control cells (p less than 0.0025). In vitro, exposure of macrophages from non-treated animals to LTA did not influence their bacterial killing ability.
D000818:Animals; D015169:Colony Count, Microbial; D008070:Lipopolysaccharides / Q000276:immunology*; D008089:Listeria monocytogenes / Q000276:immunology; D008088:Listeriosis / Q000276:immunology*; D008099:Liver / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis; D013154:Spleen / Q000382:microbiology; D013210:Staphylococcus; D013682:Teichoic Acids / Q000276:immunology*
D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid