title: Progress in T cell biology.
abstract: We outline recent work in our laboratories on thymus progenitors, lineages within the thymus, interactions between regulatory and effector lymphocytes, splitting the CD4 (T4) T cell subset, and Ir and Is genes. We highlight the possibilities for future research opened up by the demonstration that certain marrow-derived cell lines can repopulate thymic lobes in culture, and also the deep insight into the logical structure of the lymph node provided by our ability to make an exact comparison between two-cell-type and three-cell-type immunoregulatory clusters.
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte; D005802:Genes, MHC Class II; D006412:Hematopoietic Stem Cells / Q000166:cytology; D007108:Immune Tolerance; D051379:Mice; D013601:T-Lymphocytes / Q000145:classification / Q000166:cytology / Q000276:immunology
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte