Two kinds of nigrostriatal asymmetry: relationship to dopaminergic drug sensitivity and 6-hydroxydopamine lesion effects in Long-Evans rats.
Recent work in this laboratory has provided evidence for a two-population model of normal rotational behavior: some rats circle predominantly away from the side containing the striatum with the greater dopamine levels and some rats circle predominantly towards the side containing the striatum with the greater dopamine levels. The two populations also respond differently to 6-hydroxydopamine lesions of the substantia nigra ipsilateral to the preferred direction of circling. The present study replicated these findings in another strain of rats and showed further that the two populations could be distinguished behaviorally by their relative responses to indirectly acting (D-amphetamine, cocaine) and directly acting (apomorphine, pergolide) dopamine agonists. The results suggest that the two populations differ with respect to the balance between pre- and postsynaptic elements within the striatum.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000662:Amphetamines / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000187:drug effects / Q000502:physiology; D006719:Homovanillic Acid / Q000378:metabolism; D006892:Hydroxydopamines; D008297:Male; D016627:Oxidopamine; D010479:Pergolide / Q000494:pharmacology; D051381:Rats; D013045:Species Specificity; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*
D000662:Amphetamines; D006892:Hydroxydopamines; D015102:3,4-Dihydroxyphenylacetic Acid; D010479:Pergolide; D016627:Oxidopamine; D001058:Apomorphine; D004298:Dopamine; D006719:Homovanillic Acid