Testicular toxicity induced by single dosing of di- and mono-(2-ethylhexyl) phthalate in the rat.
The testicular toxicity of di-(2-ethylhexyl) phthalate (DEHP), a widely used plasticizer, and of its major metabolite, mono-(2-ethylhexyl) phthalate (MEHP), was assessed after a single dose in rats. Treatment with a single dose of 2.8 g/kg DEHP or 0.8 g/kg MEHP was sufficient to induce testicular atrophy as observed 7 days after dosing. Such a treatment had no effect on plasma FSH levels, and had varying effects on testicular zinc concentrations. After a single dose of 0.8 g/kg MEHP the testicular toxicity was age-dependent, in that only prepubertal rats were susceptible.
D000818:Animals; D004051:Diethylhexyl Phthalate / Q000633:toxicity; D005640:Follicle Stimulating Hormone / Q000097:blood; D008297:Male; D010795:Phthalic Acids / Q000633:toxicity*; D010968:Plasticizers / Q000633:toxicity*; D051381:Rats; D013737:Testis / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors; D015032:Zinc / Q000378:metabolism
D010795:Phthalic Acids; D010968:Plasticizers; D005640:Follicle Stimulating Hormone; D004051:Diethylhexyl Phthalate; D015032:Zinc