Rapid evolution in the immunochemical findings of a gamma heavy chain disease.
We noted the following major immunochemical changes in the final course of a gamma heavy-chain disease associated with a myelomonocytic leukemia: an important oligoclonal increase of IgG1/kappa, during sepsis development, whereas the lambda molecules decreased and IgG2 and IgG3 completely disappeared in a one-month interval. Initial concentrations of IgG4 were stable during that period, and gamma 1 heavy chains were slightly increased. This is a very unusual observation of the successive immunochemical events terminating a gamma heavy-chain disease.
D000368:Aged; D004586:Electrophoresis; D005260:Female; D006362:Heavy Chain Disease / Q000150:complications / Q000276:immunology*; D006801:Humans; D007122:Immunoelectrophoresis; D007074:Immunoglobulin G / Q000032:analysis / Q000652:urine; D007142:Immunoglobulin gamma-Chains / Q000032:analysis / Q000652:urine; D007145:Immunoglobulin kappa-Chains / Q000032:analysis / Q000652:urine; D007146:Immunoglobulin lambda-Chains / Q000032:analysis / Q000652:urine; D007159:Immunologic Tests; D007951:Leukemia, Myeloid / Q000150:complications / Q000276:immunology*
D007074:Immunoglobulin G; D007142:Immunoglobulin gamma-Chains; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains