title: High susceptibility of an analbuminemic congenic strain of rats with an F344 genetic background to induced bladder cancer and its possible mechanism.
abstract: The susceptibility of an analbuminemic congenic strain of rats (F344-alb) originating from the F344 strain to N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was examined. F344-alb rats were found to be highly susceptible to induction of urinary bladder cancers. The incidences of bladder cancers in F344-alb and F344 rats were 94% (15/16) and 31% (5/16) in males and 100% (16/16) and 19% (3/16) in females. The bladder weights of these rats, including tumors, were 307 +/- 294 mg, 123 +/- 26 mg, 183 +/- 80 mg and 93 +/- 11 mg, respectively. Administration of 0.05%, 0.1% and 0.3% BBN in the drinking water for 2 weeks resulted in greater increases in the bladder content of N-butyl-N-(3-carboxypropyl)nitrosamine in F344-alb rats than in F344 rats. This increase was prevented by the presence of rat albumin.
mesh_terms: D000818:Animals; D002085:Butylhydroxybutylnitrosamine / Q000378:metabolism; D002463:Cell Membrane Permeability; D004198:Disease Susceptibility; D005260:Female; D007074:Immunoglobulin G / Q000502:physiology; D008297:Male; D009602:Nitrosamines / Q000032:analysis; D051381:Rats; D011916:Rats, Inbred F344; D012709:Serum Albumin / Q000502:physiology; D013045:Species Specificity; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
chemical_list: D007074:Immunoglobulin G; D009602:Nitrosamines; D012709:Serum Albumin; D002085:Butylhydroxybutylnitrosamine; C006853:butyl(3-carboxypropyl)nitrosamine