Primary localized amyloidosis of the bladder with a monoclonal plasma cell infiltrate.
A case of primary tumour-like amyloidosis of the urinary bladder is described. The plasma cell infiltrate around the amyloid deposition revealed monoclonality by both immunoperoxidase and immunofluorescence methods and the amyloid gave a staining reaction consistent with AL type. A local tissue based immunocyte dyscrasia appears to be responsible for the tumour-like amyloid deposition.
D000328:Adult; D000686:Amyloidosis / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism; D007145:Immunoglobulin kappa-Chains; D007150:Immunohistochemistry; D008297:Male; D010950:Plasma Cells / Q000276:immunology / Q000473:pathology*; D001745:Urinary Bladder Diseases / Q000276:immunology / Q000473:pathology*
D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains