Potential roles of fibronectin in cutaneous wound repair.
Fibronectin has many potential roles in wound repair, including chemotactic factor activity for monocytes, fibroblasts, and endothelial cells; opsonin activity and opsonin promoter activity for microorganism and tissue debris; substratum for cell migration and localization; and a scaffold for building extracellular matrix. Although fibronectin has been reported to have intrinsic growth-promoting ability, coisolation of authentic growth factors with fibronectin raises doubts about this observation. Whether the addition of exogenous fibronectin to wounds can augment healing is a question for future studies.
D000210:Acute-Phase Reaction / Q000503:physiopathology; D002455:Cell Division; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology; D005353:Fibronectins / Q000627:therapeutic use*; D006801:Humans; D010587:Phagocytosis / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000503:physiopathology
D005353:Fibronectins