title: Isolation of Neisseria meningitidis strains with increase of penicillin minimal inhibitory concentrations.
abstract: We report the isolation and characterization of ten strains showing an increase in the minimal inhibitory concentrations to penicillin (MICs greater than 0.1 microgram/ml), and describe the epidemiological, clinical and microbiological features. The susceptibility of 3432 meningococcal strains isolated from patients in the recent epidemic wave (1978-86) in Spain, to several antimicrobial agents used in the treatment and chemoprophylaxis of meningococcal infection has been tested. Most were resistant to sulphadiazine but sensitive to other antibiotics. The possible existence of a new pattern of behaviour of meningococcal to penicillin is discussed.
mesh_terms: D000368:Aged; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008585:Meningitis, Meningococcal / Q000382:microbiology*; D008589:Meningococcal Infections / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D009345:Neisseria meningitidis / Q000187:drug effects* / Q000302:isolation & purification; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D013030:Spain; D013411:Sulfadiazine / Q000494:pharmacology*
chemical_list: D010406:Penicillins; D013411:Sulfadiazine