Pseudomonas aeruginosa. II. Experimental acellular vaccine of an endotoxin and anatoxin type.
The results are given of quality evaluation of endotoxin and exotoxin antigens isolated from P. aeruginosa strains. The isolates were tested by both in vitro and in vivo methods. The results of an active protection test on white mice formed the basis for the construction of an experimental Pseudomonas vaccine that protects the immunized animals against infection even by heterologous strains of P. aeruginosa.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology* / Q000302:isolation & purification; D001428:Bacterial Vaccines / Q000276:immunology*; D004731:Endotoxins / Q000276:immunology* / Q000302:isolation & purification; D005260:Female; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D011552:Pseudomonas Infections / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D011817:Rabbits; D014121:Toxoids / Q000276:immunology* / Q000302:isolation & purification
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D004731:Endotoxins; D014121:Toxoids