Platinum group metal sensitivity: reactivity to platinum group metal salts in platinum halide salt-sensitive workers.
The ability of closely related platinum group metal salts (PGMS) to cross-react with the principal sensitising agent ammonium hexachloroplatinate IV was investigated in refinery workers. Selected subjects were screened by skin prick test, specific RAST, RAST inhibition, and primate PCA tests. These showed--but only in platinum-sensitive subjects--a low prevalence of skin and RAST sensitivity to the other PGMS and limited evidence of hapten specific cross-reactivity.
D000818:Animals; D002712:Chlorides / Q000276:immunology; D003429:Cross Reactions; D004342:Drug Hypersensitivity; D000882:Haplorhini; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis*; D008669:Metallurgy; D009784:Occupational Diseases / Q000139:chemically induced / Q000175:diagnosis*; D010165:Palladium / Q000276:immunology; D010984:Platinum / Q000009:adverse effects* / Q000276:immunology; D017671:Platinum Compounds; D011852:Radioallergosorbent Test; D012238:Rhodium / Q000276:immunology; D012492:Salts; D012882:Skin Tests
D002712:Chlorides; D017671:Platinum Compounds; D012492:Salts; C018453:ammonium hexachloroplatinate; D010984:Platinum; D010165:Palladium; D012238:Rhodium