Thrazarine, a new antitumor antibiotic. II. Physico-chemical properties and structure determination.
A new antitumor antibiotic thrazarine was soluble in water and positive to anisaldehyde-sulfuric acid and ninhydrin color reactions. The absolute structure of thrazarine was determined to be O-[3R)-2-diazo-3-hydroxybutyryl)-L-serine by acid hydrolysis, spectroscopic analysis and X-ray crystallographic analysis. Structurally, thrazarine was a new member of azaserine group antibiotics.
D000903:Antibiotics, Antineoplastic; D055598:Chemical Phenomena; D002621:Chemistry; D006885:Hydroxybutyrates; D012694:Serine / Q000031:analogs & derivatives; D014961:X-Ray Diffraction
D000903:Antibiotics, Antineoplastic; D006885:Hydroxybutyrates; C058022:thrazarine; D012694:Serine