Pancreatic perivascular lipid droplets--observations on adverse effects in the rat.
A standardized method for the isolation of so-called pancreatis perivascular lipid droplets (PPD) together with cells scattered on their surface is described. After implantation of PPD into the diabetic rat, a long term increase in glycaemia was found. After prior damage to PPD by the actions of enzymes a shortening of the post implantation survival period or even death of recipients within hours was observed. Possibility of participation of PPD in toxic effects observed during pancreatitis is discussed.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000473:pathology; D016381:Islets of Langerhans Transplantation; D050356:Lipid Metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D007328:Insulin