Differential effects of hypothalamic catecholamine depletion on the release of arginine vasopressin and CRF-41 into hypothalamo-hypophyseal portal blood.
The effects of 6-hydroxydopamine lesions of the ventral noradrenergic bundle (VNAB) and of intracerebroventricular 6-hydroxydopamine on hypothalamo-hypophyseal portal blood (HPB) concentrations of arginine vasopressin (AVP), corticotrophin releasing factor (CRF-41), and noradrenaline have been investigated. VNAB lesions and intracerebroventricular 6-hydroxydopamine caused a reduction of HPB CRF-41 concentration, while AVP remained unchanged. HPB noradrenaline concentration was reduced in animals treated with lateral ventricular 6-hydroxydopamine, but was unchanged in VNAB lesioned animals. Our results suggest differential effects of noradrenaline on the release of AVP and CRF-41 into HPB.
D000320:Adrenergic Fibers / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood*; D003346:Corticotropin-Releasing Hormone / Q000097:blood*; D006892:Hydroxydopamines; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D007031:Hypothalamus / Q000098:blood supply / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000097:blood; D016627:Oxidopamine; D011168:Portal System / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D006892:Hydroxydopamines; D001127:Arginine Vasopressin; D016627:Oxidopamine; D003346:Corticotropin-Releasing Hormone; D009638:Norepinephrine