title: [Hormonal properties of new 17 alpha-hydroxyprogesterone derivatives].
abstract: The paper is devoted to an experimental study of the hormonal properties of two new derivatives of 17 alpha-oxyprogesterone--mepregenol monoacetate and mepregenol diacetate--for their possible use as minipills. Both compounds showed a high progestational activity which was much higher than that of progesterone and the activity of alpha-norgestrel in peroral administration. The above compounds made no inhibitory effect on hypophyseal gonadotropic function; on the contrary, they stimulated follitropine secretion. Besides, different dose-related influence of the steroids on a progesterone level was revealed: the use of small doses resulted in enhanced secretion and larger doses brought about the suppression of secretion. Thus, the new compounds of the progesterone series--mepregenol monoacetate and mepregenol diacetate--appear promising compounds for monohormonal contraception and for the management of conditions with lowered function of the corpus luteum.
mesh_terms: D019326:17-alpha-Hydroxyprogesterone; D000818:Animals; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006908:Hydroxyprogesterones / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood; D011244:Pregnadienediols / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood; D011817:Rabbits; D011863:Radioimmunoassay; D051381:Rats
chemical_list: D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D006908:Hydroxyprogesterones; D011244:Pregnadienediols; C027475:mepregenol diacetate; D011374:Progesterone; D019326:17-alpha-Hydroxyprogesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
vernacular_title: Gormonal'nye svoĭstva novykh proizvodnykh 17 al'fa-oksiprogesterona.