Synthesis and antibacterial activity of 6-difluoromethoxy-7-piperazinyl-3-quinolinecarboxylic acid derivatives.
A series of novel 3-quinolinecarboxylic acid derivatives has been prepared and their antibacterial activity evaluated. These derivatives were characterized by a difluoromethoxy group attached to the 6-position and substituted piperazinyl groups attached to the 7-position.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004926:Escherichia coli / Q000187:drug effects; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D015363:Quinolones
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D011804:Quinolines; D015363:Quinolones; C056839:6-difluoromethoxy-7-piperazinyl-3-quinolonecarboxylic acid