Effects of superselective arterial embolization and chemoembolization on energy charge and total blood flow of the rat liver.
The superselective transcatheter arterial embolization (TAE) and chemoembolization (TAC) of the periphery of the left and median lobes of the rat liver were performed using 1.5 mg of gelatin sponge dissolved in saline solution and mitomycin (MMC) at a dose of 1.6 mg/kg b.wt. The energy charge (EC) of the embolized and chemoembolized lobes decreased after the embolization but was restored 3 h later. The total hepatic blood flow (THBF) was reduced to about one half and required 1 week to be restored to the preembolization levels in both groups. Microscopic centrilobular necrosis and vacuolization were found. The addition of MMC did not produce marked untoward effects. Thus, the normal liver is able to restore its energy pool despite a reduction in the THBF after superselective arterial embolization, and this recovery is not altered even by the use of a high dose of MMC.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D001783:Blood Flow Velocity; D004621:Embolization, Therapeutic; D004734:Energy Metabolism; D006499:Hepatic Artery; D008099:Liver / Q000378:metabolism*; D008102:Liver Circulation; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000227:Adenine Nucleotides; D008937:Mitomycins; D016685:Mitomycin