title: Toxicity of nickel and silver to Nostoc muscorum: interaction with ascorbic acid, glutathione, and sulfur-containing amino acids.
abstract: Exposure of Nostoc muscorum to different concentrations of Ni and Ag brought about reduction in growth, carbon fixation, heterocyst production, and nitrogenase activity and increase in the loss of ions (K+, Na+). In an attempt to ameliorate the toxicity of test metals by ascorbic acid, glutathione, and sulfur-containing amino acids (L-cysteine and L-methionine), it was found that the level of protection by ascorbic acid and glutathione was more for Ag than Ni. However, metal-induced inhibition of growth and carbon fixation was equally ameliorated by methionine. But the level of protection by cysteine was quite different, i.e., 27% for Ni and 22% for Ag. Protection of metal toxicity in N. muscorum by amino acids lends further support to self-detoxifying ability of cyanobacteria because they are known to synthesize all essential amino acids.
mesh_terms: D000603:Amino Acids, Sulfur / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D002245:Carbon Dioxide / Q000378:metabolism; D056890:Eukaryota / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D005978:Glutathione / Q000494:pharmacology; D009532:Nickel / Q000633:toxicity*; D009591:Nitrogenase / Q000378:metabolism; D012834:Silver / Q000633:toxicity*; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D000603:Amino Acids, Sulfur; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D002245:Carbon Dioxide; D012834:Silver; D009532:Nickel; D009591:Nitrogenase; D005978:Glutathione; D001205:Ascorbic Acid