title: c-fos proto-oncogene expression in human NK/LGL cells: expression is not constitutive and is associated with functional activation.
abstract: Unlike mature myeloid and monocytic cells and cell lines committed to terminal myelomonocytic differentiation, highly purified preparations of human natural killer cells/large granular lymphocytes (NK/LGL) did not spontaneously express the c-fos proto-oncogene. Transient expression of c-fos in NK/LGL was associated with functional activation with IL-2, IFN-gamma, LPS and PMA, which increased their cytotoxic activity, lymphokine secretion and in vitro chemotaxis. These results, together with the finding that T-cell receptor genes are in germ-line configuration in the vast majority of peripheral blood NK/LGL, are compatible with the hypothesis that these cells represent a separate hematopoietic lineage.
mesh_terms: D002772:Cholera Toxin / Q000494:pharmacology; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000276:immunology / Q000648:ultrastructure*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D007376:Interleukin-2; D008070:Lipopolysaccharides; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D007371:Interferon-gamma; D002772:Cholera Toxin; D013755:Tetradecanoylphorbol Acetate