Fatal acute respiratory failure following vinblastine and mitomycin administration for breast cancer.
We report a case of acute fatal respiratory failure following mitomycin and vinblastine administration in a patient with metastatic breast cancer. This case, the first reported fatal case in a breast cancer patient and also the first fatal case in a nonsmoker, suggests an acute hypersensitivity reaction as the cause of the respiratory distress.
D000208:Acute Disease; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006801:Humans; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D012130:Respiratory Hypersensitivity / Q000139:chemically induced; D012131:Respiratory Insufficiency / Q000139:chemically induced*; D014747:Vinblastine / Q000008:administration & dosage
D008937:Mitomycins; D016685:Mitomycin; D014747:Vinblastine