Protein redistribution diet restores motor function in patients with dopa-resistant "off" periods.
Sixteen parkinsonians with acquired drug-resistant "off" periods without dyskinesia were placed on a diet in which virtually all protein was concentrated in the evening meal. Restoration of sensitivity to levodopa resulted in 88%. Ten patients (62%) have continued to comply with the diet for 7 months (mean). Two patients were studied in detail. Immobility correlated with elevated plasma levels of large neutral amino acids (LNAA), normality with low LNAA.
D000596:Amino Acids / Q000097:blood; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000627:therapeutic use; D004295:Dihydroxyphenylalanine / Q000627:therapeutic use*; D004351:Drug Resistance; D005500:Follow-Up Studies; D006801:Humans; D009043:Motor Activity / Q000187:drug effects*; D009994:Osmolar Concentration; D010300:Parkinson Disease / Q000097:blood / Q000178:diet therapy* / Q000188:drug therapy / Q000503:physiopathology
D000596:Amino Acids; D004044:Dietary Proteins; D004295:Dihydroxyphenylalanine