Relationships between structure and mutagenic activity of environmental chemicals.
This review analyzes relationships between chemical structure and biological activity for several series of compounds. Its focus is on mutagenicity and carcinogenicity and the predictability of these properties on the basis of the chemical structure. Examples are selected from monocyclic aromatic amines, benzidine derivatives, aminoazobenzene derivatives, nitrofurans, aflatoxins, and sterigmatocystins. Results from mutagenicity tests in Salmonella typhimurium are summarized, and their correlation with carcinogenicity is discussed. The review is concluded with generalizations on the usefulness of studies on relationships between chemical structure and mutagenic activity.
D000348:Aflatoxins; D001560:Benzidines; D002273:Carcinogens; D004785:Environmental Pollutants / Q000633:toxicity*; D009153:Mutagens; D009581:Nitrofurans; D013241:Sterigmatocystin; D013329:Structure-Activity Relationship; D004124:p-Dimethylaminoazobenzene
D000348:Aflatoxins; D001560:Benzidines; D002273:Carcinogens; D004785:Environmental Pollutants; D009153:Mutagens; D009581:Nitrofurans; D013241:Sterigmatocystin; D004124:p-Dimethylaminoazobenzene