Unique DNA repair properties of a xeroderma pigmentosum revertant.
A group A xeroderma pigmentosum revertant with normal sensitivity was created by chemical mutagenesis. It repaired (6-4) photoproducts normally but not pyrimidine dimers and had near normal levels of repair replication, sister chromatid exchange, and mutagenesis from UV light. The rate of UV-induced mutation in a shuttle vector, however, was as high as the rate in the parental xeroderma pigmentosum cell line.
D015112:4-Nitroquinoline-1-oxide; D002461:Cell Line, Transformed; D004260:DNA Repair; D006801:Humans; D008769:Methylnitronitrosoguanidine; D009154:Mutation / Q000187:drug effects / Q000528:radiation effects; D011740:Pyrimidine Dimers; D012854:Sister Chromatid Exchange; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000235:genetics*
D011740:Pyrimidine Dimers; D008769:Methylnitronitrosoguanidine; D015112:4-Nitroquinoline-1-oxide