title: Plasmid-mediated sulfonamide resistance in Neisseria meningitidis.
abstract: An 8.5-megadalton plasmid coding for sulfonamide resistance was found in a clinical isolate of Neisseria meningitidis, as demonstrated by plasmid elimination and transformation experiments. The plasmid complemented a mutation which determines the production of a thermosensitive dihydropteroate synthetase in Escherichia coli, thus suggesting that the mechanism of resistance involved a plasmid-encoded dihydropteroate synthetase.
mesh_terms: D004352:Drug Resistance, Microbial; D009345:Neisseria meningitidis / Q000187:drug effects* / Q000235:genetics; D010957:Plasmids; D013307:Streptomycin / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology*; D013696:Temperature
chemical_list: D013449:Sulfonamides; D013307:Streptomycin