[Pharmacological analysis of morphofunctional changes in the adrenergic structures of the pancreas as affected by lesions of the endocrine and exocrine pancreas].
The adrenergic section of the vegetative pancreatic innervation has been examined, using morphological, histochemical and biochemical methods, during neurogenic injury, acute experimental pancreatitis and alloxan diabetes. It has been established that the development of those etiologically different processes was accompanied by catecholamine level reduction in the adrenergic structures of the pancreas which can be prevented by ganglioblockers. It is concluded that sympathetic nervous system participates in etiopathogenesis of a number of pancreatic diseases and that it is possible to prevent and treat them with sympathotropic agents.
D000320:Adrenergic Fibers / Q000503:physiopathology*; D000818:Animals; D001285:Atropine / Q000627:therapeutic use; D004295:Dihydroxyphenylalanine / Q000627:therapeutic use; D006584:Hexamethonium Compounds / Q000627:therapeutic use; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D010179:Pancreas / Q000294:innervation*; D010182:Pancreatic Diseases / Q000503:physiopathology* / Q000517:prevention & control; D010643:Phenoxybenzamine / Q000627:therapeutic use; D010725:Phosphocreatine / Q000378:metabolism; D011433:Propranolol / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats
D006584:Hexamethonium Compounds; D010725:Phosphocreatine; D010643:Phenoxybenzamine; D004295:Dihydroxyphenylalanine; D001285:Atropine; D011433:Propranolol; C021628:benzohexonium; D009638:Norepinephrine
Farmakologicheskiĭ analiz morfofunktsional'nykh izmeneniĭ adrenergicheskikh struktur podzheludochnoĭ zhelezy pri porazhenii ee éndo- i ékzokrinnogo otdela.