Elimination of UV-resistance inducing effect of R46 R factor by 5-fluorouracil.
R-factor curing capacity of 5-fluorouracil (5-FU) was studied. Well detectable increase in UV-resistance was found in E. coli K12 AB1157 strain and its recB-, recC-, recF- mutants harbouring R46 R-factor. After treatment with 5-FU, these strains lost not only the antibiotic resistance coded for R46 R-factor but their UV-radioresistance, as well.
D004307:Dose-Response Relationship, Radiation; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D005472:Fluorouracil / Q000494:pharmacology*; D009154:Mutation; D011815:R Factors / Q000187:drug effects / Q000528:radiation effects*; D014466:Ultraviolet Rays
D005472:Fluorouracil