Chemotherapy of human non-Hodgkin lymphoma (NHL) xenografts.
Three human NHL (B-cell type) were established successfully as serially transplantable xenografts in artificially immunesuppressed CBA mice. All of them preserved the phenotypic characteristics of the original tumour even after several passages. The transplanted tumours were highly sensitive to cyclophosphamide and methotrexate, reflecting the results obtained in clinical practice, and relatively sensitive to dianhydrogalactitol.
D000818:Animals; D001402:B-Lymphocytes; D003520:Cyclophosphamide / Q000627:therapeutic use; D004247:DNA / Q000032:analysis; D003961:Dianhydrogalactitol / Q000627:therapeutic use; D006801:Humans; D007124:Immunoenzyme Techniques; D007621:Karyotyping; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000473:pathology; D008727:Methotrexate / Q000627:therapeutic use; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous
D003961:Dianhydrogalactitol; D003520:Cyclophosphamide; D004247:DNA; D008727:Methotrexate