title: Vestibulo-ocular (VOR) abnormalities at high rotational frequencies in patients with Menière's disease.
abstract: Although visual feedback is required to maintain gaze stability during low-frequency rotations (below 1 Hz) because of suboptimal VOR gain in this frequency range, such behavior is not as evident at higher frequencies. Benson and Hydén et al. noted a steady increase in VOR gain in the higher-frequency range (2 to 5 Hz), where visual feedback has little effect. Similar behavior has also been reported in the monkey models. Eleven patients with diagnoses of Meniere's disease had tests of VOR and VOR cancellations performed with the use of pseudorandom oscillations as high as 5 Hz. The responses at various frequencies were compared with normal data from 17 subjects. The VOR gain in patients exhibited a more rapid rise at high frequencies than that observed in normal subjects. For example, at 3.5 Hz the normal gain was 1.09, whereas patients exhibited a gain of 1.35 (mean of 11 subjects). When the performance during VOR cancellation tasks was compared, Meniere's patients appeared to be less able to perform these tasks; however, when the values were compared by use of a cancellation index that compensates for any difference in VOR gain, this apparent difference disappeared.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000503:physiopathology*; D012027:Reflex, Vestibulo-Ocular; D012399:Rotation