[Influence of gamma irradiation on the chemiluminescence of alveolar macrophages in guinea pigs at rest or activated].
The capacity of Guinea Pig alveolar macrophages to produce oxygenated free radicals after in vitro gamma irradiation was studied. We observed an increase of resting cell chemiluminescence with 3 Gy, then an important decrease from 3 Gy to 30 Gy. Chemiluminescence of zymosan activated macrophages was reduced at 10 Gy and 30 Gy, while activation by IgG anti-MHC antigens was not affected by the same radiation doses. These results could be of great interest for the study pulmonary defense mechanisms after irradiation.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals; D005720:Gamma Rays; D006168:Guinea Pigs; D006649:Histocompatibility Antigens / Q000276:immunology; D007074:Immunoglobulin G / Q000502:physiology; D008163:Luminescent Measurements; D008262:Macrophage Activation / Q000187:drug effects / Q000528:radiation effects*; D008264:Macrophages / Q000502:physiology / Q000528:radiation effects*; D011650:Pulmonary Alveoli / Q000166:cytology*; D015054:Zymosan / Q000494:pharmacology
D005609:Free Radicals; D006649:Histocompatibility Antigens; D007074:Immunoglobulin G; D015054:Zymosan
Etude de l'influence de l'irradiation gamma sur la chimioluminescence de macrophages alvéolaires de cobaye au repos ou activés.