title: Bilateral upper extremity ischemia after administration of dihydroergotamine-heparin for prophylaxis of deep venous thrombosis.
abstract: Prolonged arterial spasm as a complication of ergot-containing medications has been reported since antiquity. This article describes our experience with a patient who had severe bilateral arterial spasm in the upper extremities 6 days after the initiation of a regimen of dihydroergotamine and heparin for prophylaxis against deep venous thrombosis. The spasm was refractory to oral calcium channel blocking agents and direct intraarterial infusion of tolazoline (Priscoline). However, intraarterial nitroglycerin produced a prompt and dramatic improvement in symptoms and in physical and arteriographic findings. This experience suggests that intraarterial nitroglycerin may be an appropriate first choice for ergot-induced arterial spasm.
mesh_terms: D001132:Arm / Q000098:blood supply*; D001916:Brachial Artery / Q000187:drug effects*; D004087:Dihydroergotamine / Q000009:adverse effects* / Q000627:therapeutic use; D004338:Drug Combinations / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006495:Heparin, Low-Molecular-Weight; D006801:Humans; D007511:Ischemia / Q000209:etiology*; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use; D013035:Spasm / Q000139:chemically induced; D013924:Thrombophlebitis / Q000517:prevention & control*; D014652:Vascular Diseases / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D004338:Drug Combinations; D006495:Heparin, Low-Molecular-Weight; C031388:heparin-dihydergot; D004087:Dihydroergotamine; D006493:Heparin; D005996:Nitroglycerin