Apomorphine induces latent rotation in lesioned rats, amphetamine does not.
Rats with unilateral 6-hydroxydopamine (6HDA) lesions of one nigrostriatal pathway were used to compare the efficacy of apomorphine (Apo) and (+)-amphetamine (Amph) at inducing latent rotational behavior. Rats treated with Apo rotated contralaterally acutely after drug treatment and subsequently, weeks after drug treatment, exhibited rapid contralateral circling when re-introduced to the rotation environment. Amph treated animals, on the other hand, rotated ipsilaterally acutely after drug treatment and exhibited no latent drug effect.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*
D006892:Hydroxydopamines; D016627:Oxidopamine; D000661:Amphetamine; D001058:Apomorphine