HIV-2 antisera cross-neutralize HIV-1.
The neutralization properties of three independent HIV-2 isolates were examined in comparison with four diverse HIV-1 strains. Human sera containing antibodies specific to HIV-2 can cross-neutralize HIV-1. By contrast, HIV-1 sera are group-specific and have no neutralizing effect on HIV-2. Therefore, HIV-2 antigens may be important components for the development of broadly cross-protective AIDS vaccines.
D000914:Antibodies, Viral / Q000502:physiology*; D000918:Antibody Specificity; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D009500:Neutralization Tests / Q000379:methods; D011233:Precipitin Tests
D000914:Antibodies, Viral; D015483:HIV Antibodies; D007106:Immune Sera