Effects of pentobarbital and progesterone on random ratio responding in male and female rats.
Intact male and ovariectomized female rats were trained to lever press under a random ratio (RR) schedule of food reinforcement. Effects of different doses of pentobarbital (1-16 mg/kg) and progesterone (10-80 mg/kg) on response output were studied. Low doses of pentobarbital increased responding, high doses decreased responding. Sex differences were observed in the rate-decreasing effects of high doses of pentobarbital. Progesterone increased the response rate of ovariectomized females, but did not affect responding in intact males.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D005260:Female; D008297:Male; D010053:Ovary / Q000502:physiology; D010424:Pentobarbital / Q000494:pharmacology*; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012055:Reinforcement Schedule; D012737:Sex Factors
D011374:Progesterone; D010424:Pentobarbital