Serum antibodies to brain proteins in a patient with parkinsonism associated with IgM paraproteinemia.
We report a 58 year-old man with various neurological symptoms as parkinsonism, autonomic dysfunction, mental deterioration and lower motor neuron involvement associated with IgM gammopathy whose serum showed antibody activities to human brain proteins. His serum reacted with 156kDa protein from substantia nigra and 130kDa of cerebral cortical grey matter, cerebellar cortex, putamen, thalamus or pallidum by immunoblotting method. The serum of this patient reacted with proteins widely distributed in the central nervous system, and this antibody in his serum might be the cause of his various neurological symptoms.
D001323:Autoantibodies / Q000032:analysis; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000276:immunology; D001921:Brain / Q000276:immunology; D003704:Dementia / Q000150:complications / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications / Q000276:immunology*; D007075:Immunoglobulin M / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009133:Muscular Atrophy / Q000150:complications / Q000276:immunology; D009419:Nerve Tissue Proteins / Q000276:immunology*; D010300:Parkinson Disease / Q000150:complications / Q000276:immunology*
D001323:Autoantibodies; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D009419:Nerve Tissue Proteins