Minimum anesthetic dose and cardiopulmonary dose response for halothane in chickens.
The minimum anesthetic dose (MAD) and the cardiopulmonary dose-response for halothane were determined in male chickens. The MAD for halothane was 0.85 +/- 0.09% (mean +/- SD), with a range of 0.75% to 0.98%. There was a significant (P less than 0.002) positive correlation between increasing concentrations of halothane and PaCO2, and significant negative correlations of halothane concentration with respiratory rate (P less than 0.04), arterial blood pH (P less than 0.008), and mean arterial blood pressure P less than 0.008). A significant correlation was not found between halothane concentration and heart rate or arterial blood bicarbonate concentration. It was concluded that the MAD for halothane in chickens is similar to values for minimum alveolar concentrations of halothane in mammalian species, and that there is substantial dose-dependent depression of cardiopulmonary function in chickens.
D000768:Anesthesia, General / Q000662:veterinary*; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001784:Blood Gas Analysis / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects*; D002245:Carbon Dioxide / Q000097:blood; D002645:Chickens / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006221:Halothane / Q000008:administration & dosage* / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008297:Male; D012119:Respiration / Q000187:drug effects*
D001639:Bicarbonates; D002245:Carbon Dioxide; D006221:Halothane