[Morphometric studies of the visual system of the rat following elimination of noradrenergic afferent pathways with 6-hydroxydopamine].
The cell density and the cell size were investigated in the dorsal lateral geniculate body (d lgn) and in the visual cortex (V.C.) of 6-hydroxydopamine (6-OHDA) treated rats and compared with control-rats. Following i. p. administration of 6-OHDA at the first postnatal day no catecholaminergic fibres were present in the d lgn and V.C. on 21st postnatal day. The results of the morphometric investigations have shown an increased cell size and cell density in the medial and caudal part of the d lgn. In the visual cortex cell size is decreased in nearly all laminae. The cell density in the V.C. increased in the laminae II, IV, VIb and c and decreased in the lamina VIa. The possible trophic or regulatory influences of the noradrenergic system on cell size and cell density is discussed.
D000818:Animals; D002452:Cell Count / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D005829:Geniculate Bodies / Q000166:cytology* / Q000187:drug effects; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D008856:Microscopy, Fluorescence; D009638:Norepinephrine / Q000502:physiology*; D016627:Oxidopamine; D051381:Rats; D014793:Visual Cortex / Q000166:cytology* / Q000187:drug effects; D014795:Visual Pathways / Q000166:cytology / Q000187:drug effects
D006892:Hydroxydopamines; D016627:Oxidopamine; D009638:Norepinephrine
Morphometrische Untersuchungen im visuellen System der Ratte nach Ausschaltung noradrenerger Afferenzen mit 6-Hydroxydopamin.