title: [Effect of gamma irradiation on the immunological properties of the brucellar protective antigen].
abstract: It was shown that the splenocytic response to mitogens in guinea pigs was activated 7 days following immunization thereof with a gamma-irradiated brucellar protective agent (gamma-BPA), while nonirradiated BPA inhibited lymphocyte proliferation under the effect of mitogens. gamma-BPA, as compared with BPA, circulated in blood for a longer time, induced a more rapid and prolonged synthesis of antibodies, and provided the development of a more intensive immunity.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000942:Antigens, Bacterial / Q000276:immunology / Q000528:radiation effects*; D002003:Brucella abortus / Q000276:immunology*; D002478:Cells, Cultured; D005260:Female; D005720:Gamma Rays; D006168:Guinea Pigs; D007114:Immunization; D008213:Lymphocyte Activation; D008297:Male; D008934:Mitogens / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D008934:Mitogens
vernacular_title: Vliianie gamma-oblucheniia na immunologicheskie svoĭstva brutselleznogo protektivnogo antigena.