New antibiotics 4181-A and B from Streptomyces griseus; taxonomy, fermentation, isolation and characterization.
The new antibiotics 4181-A and B were isolated from the fermentation broth of Streptomyces griseus, a soil isolate. Their molecular formulae were determined as C29H21NO9 and C28H19NO9, respectively. The UV, IR and NMR spectra suggest that they possess a quinone moiety in their structures. They were found to have antibacterial, antifungal and antitumor activity.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D011809:Quinones / Q000302:isolation & purification; D013305:Streptomyces griseus / Q000145:classification* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D011809:Quinones; C055841:antibiotic 4181-B; C055839:antibiotic 4181-A