Effect of tryptophan on livers of pregnant and lactating rats and their fetuses and pups.
The effect of the administration of L-tryptophan on hepatic polyribosomes and protein synthesis in pregnant rats and their fetuses and in lactating rats and their pups was investigated. Pregnant rats tube-fed tryptophan 1 hr before killing revealed increased hepatic protein synthesis but essentially unmodified polyribosomal aggregation of maternal livers while no changes were observed in fetal livers in comparison to controls (water-treated). Lactating rats tube-fed tryptophan 1 hr before killing revealed increased polyribosomal aggregation and protein synthesis of the livers in comparison to controls. Pups of these mothers that received tryptophan intraperitoneally 1 hr before killing did not reveal a significant change in the hepatic polyribosomes or protein synthesis.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D000833:Animals, Suckling / Q000378:metabolism; D004750:Enteral Nutrition; D005260:Female; D005333:Fetus / Q000187:drug effects*; D007774:Lactation / Q000187:drug effects*; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D011132:Polyribosomes / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D014364:Tryptophan / Q000008:administration & dosage*
D014364:Tryptophan; D007930:Leucine