Induction of continuous I-A expression by murine peritoneal macrophages: lack of correlation with T cell responses of Bcgr and Bcgs mice.
The induction of continuous I-A expression by L3T4 and Lyt2 lymphocyte subpopulations from Bcgr and Bcgs mice was compared. We found that the induction of continuous I-A expression was independent of the Bcg genotype of the T cells. T cells from congenic Bcgs BALB/c mice and C.D2Bcgr mice could not induce continuous I-A expression in vitro and were deficient in their ability to produce IFN-gamma in vitro. In contrast, T cells from other strains of Bcgr and Bcgs mice could induce continuous I-A expression. Both recombinant IL-2 and IL-4 acted synergistically with low levels of IFN-gamma to induce continuous I-A expression by macrophages from Bcgr mice.
D000818:Animals; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000096:biosynthesis / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009163:Mycobacterium bovis / Q000276:immunology*; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D007376:Interleukin-2; D007371:Interferon-gamma