title: Mutagenicity testing of the pyrethroid insecticide cypermethrin in Drosophila.
abstract: The pyrethroid insecticide cypermethrin was tested for the induction of genetic damage in male germ cells of Drosophila melanogaster. Sex-linked recessive lethals, sex-chromosome loss and non-disjunction were studied following different routes of administration: adult feeding, injection and larval feeding. Our results show that, after adult injection and larval ingestion, cypermethrin induces a small but significant increase in the frequency of sex-linked recessive lethal mutations. However, no significant increases were observed in the frequency of sex chromosome loss or non-disjunction after exposure of male flies to cypermethrin at concentrations up to 20 p.p.m.
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects; D005260:Female; D005804:Genes, Lethal / Q000187:drug effects; D005808:Genes, Recessive / Q000187:drug effects; D007305:Insecticide Resistance; D008297:Male; D009153:Mutagens; D009630:Nondisjunction, Genetic; D011722:Pyrethrins / Q000633:toxicity*; D012730:Sex Chromosomes / Q000187:drug effects
chemical_list: D009153:Mutagens; D011722:Pyrethrins; C017160:cypermethrin