[A case of recurrent epipharyngeal cancer showing complete disappearance following suppository administration of tegafur (Sunfural rectal capsules)].
A 55-year-old woman was diagnosed as having epipharyngeal cancer, characterized by T2N1M0 and poorly differentiated squamous cell carcinoma. She was treated by radiotherapy (primary site: 65 Gy, neck: 75 Gy) and the tumor completely disappeared. However, 4 months later, the tumor recurred in the epipharynx. Tegafur in the form of a suppository (Sunfural Rectal Capsules, 750 mg) was given once a day. During the course of epipharyngoscopic follow-up the tumor almost totally disappeared at a dose of 10,250 mg (15 days). Biopsy failed to reveal any cancer cells and computed tomography showed no tumor masses in the epipharynx. At present, 6 months have already passed since the start of Tegafur administration, there is no recurrence of the cancer, and the chemotherapy is being continued at our outpatient clinic. By the standard for the efficacy of cancer chemotherapy proposed by Koyama and Saito, this case corresponds to a state of complete response.
D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D010610:Pharyngeal Neoplasms / Q000188:drug therapy*; D012074:Remission Induction; D013488:Suppositories; D005641:Tegafur / Q000008:administration & dosage*
D013488:Suppositories; D005641:Tegafur