F-19 MR imaging of glucose metabolism in the rabbit.
Noninvasive metabolic magnetic resonance (MR) imaging reflecting glucose metabolism in the aldose-reductase-sorbitol (ARS) pathway was performed in the rabbit head; after administration of the fluorinated glucose analogue 3-fluoro-3-deoxy-D-glucose (3FD-glucose), fluorine-19 images were generated. Images of 3FD-glucose showed significant 3FD-glucose uptake by adipose tissue, indicating its buffering effects in case of excess loads of glucose. Images of 3-fluoro-3-deoxy-D-sorbitol (3FD-sorbitol) demonstrated the spatial distribution of aldose reductase activities and significant sorbitol accumulation in the lens. Images of 3-fluoro-3-deoxy-D-fructose (3FD-fructose) showed preferential uptake of fructose by muscle tissue. The extremely low toxicity of 3FD-glucose indicates promise for its clinical application in metabolic imaging.
D000449:Aldehyde Reductase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D003837:Deoxy Sugars; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005461:Fluorine; D005947:Glucose / Q000378:metabolism*; D006257:Head / Q000033:anatomy & histology; D007908:Lens, Crystalline / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D009132:Muscles / Q000378:metabolism; D011817:Rabbits; D013012:Sorbitol / Q000378:metabolism
D003837:Deoxy Sugars; C007253:3-deoxy-3-fluoro-D-glucose; D005461:Fluorine; D013012:Sorbitol; D003847:Deoxyglucose; D000449:Aldehyde Reductase; D005947:Glucose