Decreased locomotor activity produced by repeated, but not single, administration of murine-recombinant interferon-gamma in mice.
A single treatment with murine-recombinant interferon-gamma (murIFN-gamma; 30 micrograms/mouse), whether evaluated immediately after, or four hrs after, intraperitoneal injection, does not alter open field activity levels. On the other hand, repeated murIFN-gamma administration (30 micrograms/mouse/day for 5 days) results in decreased spontaneous locomotor activity and an increase in body weight.
D000818:Animals; D004334:Drug Administration Schedule; D007371:Interferon-gamma / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D007371:Interferon-gamma