[Submicroscopic restructurings in the glomerular portion of the rat nephron in streptozotocin diabetes and their possible drug correction].
Experiments on Wistar male rats have shown that in 2 weeks the administration of streptozotocin results in an increase in relative kidney mass by 23%, the development of submicroscopic rearrangements indicating the hypertrophy of the main glomerular components and the acceleration of ultrafiltration. In one month a sharp widening of the lumens of capillaries and intersubosseous spaces, inflammatory symptoms, and signs of primary urine congestion are noted in parallel with hypertrophic changes. The relative kidney mass increases by 73.5% (p less than 0.01). The use of the aldose reductase blocker isodibut prevents, to a great extent, the development of ultrastructural changes in a glomerulus detected one month after administration of streptozotocin, improves ultrafiltration and inhibits a sharp increase in kidney mass, i. e. it prevents disorder of renal excretory function at the initial stages of experimental diabetes.
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000473:pathology*; D004353:Drug Evaluation, Preclinical; D006984:Hypertrophy / Q000188:drug therapy / Q000473:pathology; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007546:Isoquinolines / Q000627:therapeutic use*; D007678:Kidney Glomerulus / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*; D013997:Time Factors
D007004:Hypoglycemic Agents; D007546:Isoquinolines; C053669:isodibut; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase
Submikroskopicheskie perestroĭki v klubochkovom otdele nefrona krys pri streptozototsinovom diabete i vozmozhnost' ikh medikamentoznoĭ korrektsii.