title: The yeast ADR6 gene encodes homopolymeric amino acid sequences and a potential metal-binding domain.
abstract: The ADR6 gene of Saccharomyces cerevisiae has an open reading frame which could encode a polypeptide of 1314 amino acids. The predicted mRNA encodes a protein with homopolymeric stretches of asparagine and threonine, particularly near its amino terminus and contains additional sequences consisting of polyglutamine repeats. The predicted protein also contains a potential metal binding (Cys)4-type finger near its carboxy-terminus. An ADR6/beta-galactosidase fusion protein was predominantly nuclear in location, consistent with its role as an activator of ADH2 transcription.
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000595:Amino Acid Sequence; D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000235:genetics; D005796:Genes; D005800:Genes, Fungal; D005809:Genes, Regulator; D008667:Metalloproteins / Q000235:genetics; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics*; D014158:Transcription, Genetic; D015032:Zinc / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D008667:Metalloproteins; D012333:RNA, Messenger; D000426:Alcohol Dehydrogenase; D015032:Zinc