title: Genetic complementation of defects in vaccine-induced immunity against Schistosoma mansoni in P- and A-strain inbred mice.
abstract: Inbred P- and A-strain mice are deficient in their capacity to develop resistance to challenge infection in response to vaccination with irradiated cercariae of Schistosoma mansoni and are also defective in their cell-mediated response as assessed by the activity of antigen-elicited macrophages in killing schistosome larvae in vitro. In contrast, vaccinated (P x A)F1 mice displayed high levels of both immunity to challenge and macrophage larvicidal activity, indicating that the P- and A-strain defects in the vaccine-induced response are controlled by distinct genetic loci.
mesh_terms: D000818:Animals; D005816:Genetic Complementation Test; D007111:Immunity, Cellular; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D012555:Schistosomiasis mansoni / Q000235:genetics* / Q000276:immunology; D014611:Vaccination; D014612:Vaccines / Q000276:immunology
chemical_list: D014612:Vaccines