[Pre- and post-operative adjuvant chemotherapy of colorectal cancer. Part 1. Drug concentration in tissues following UFT administration].
The concentration of Tegafur, 5-FU and Uracil in tumor and normal tissue were measured in 47 colorectal cancer patients who had been administered UFT (400/mg) for seven days before operation. The concentration of Tegafur, 5-FU and Uracil in tumor was higher than in normal tissue (p less than 0.01), and the concentration of 5-FU was correlative to the concentration of Tegafur and Uracil in both tissues. The Dukes group and histological type were not related to the concentration of Tegafur, 5-FU and Uracil in either tissue. The uptake of each drug was good and high in tumor tissue.
D000971:Antineoplastic Combined Chemotherapy Protocols; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D005472:Fluorouracil / Q000493:pharmacokinetics*; D006801:Humans; D011184:Postoperative Period; D005641:Tegafur / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014498:Uracil / Q000008:administration & dosage / Q000493:pharmacokinetics*
D005641:Tegafur; D014498:Uracil; D005472:Fluorouracil