title: Susceptibility of Schistosoma mansoni prevalent in Saudi Arabia to oxamniquine in experimentally infected mice.
abstract: The therapeutic efficiency of oxamniquine against the local strain of Schistosoma mansoni was investigated in experimentally infected mice. The drug was administered orally using a human-equivalent dose of 20 mg kg-1 day-1 for 3 consecutive days (total dose of 60 mg kg-1). Oxamniquine proved to be very effective as indicated by hepatic shift, oogram changes, complete elimination of adult worms and eradication of faecal eggs.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005243:Feces / Q000469:parasitology; D005260:Female; D008099:Liver / Q000469:parasitology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009600:Nitroquinolines / Q000627:therapeutic use*; D010073:Oxamniquine / Q000008:administration & dosage / Q000627:therapeutic use*; D010270:Parasite Egg Count; D012529:Saudi Arabia; D012550:Schistosoma mansoni / Q000187:drug effects; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000469:parasitology
chemical_list: D009600:Nitroquinolines; D010073:Oxamniquine