Interleukin-2 production and effect of thymosin fraction 5 on interleukin-2 production in rheumatoid arthritis.
Interleukin-2 (IL-2) production and effects of thymosin fraction 5 (F5) on IL-2 production by peripheral blood mononuclear cells from patients with active rheumatoid arthritis (RA) were studied. Three patients with RA had elevated IL-2 production which was which was suppressed by F5. IL-2 production by peripheral blood mononuclear cells from 17 other patients with RA was similar to controls and was not affected by F5. Our results are consistent with hyperproduction of IL-2 by some patients with RA which is suppressed by F5.
D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000628:therapy; D006051:Aurothioglucose / Q000627:therapeutic use; D002478:Cells, Cultured; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007376:Interleukin-2 / Q000096:biosynthesis*; D009000:Monocytes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013947:Thymosin / Q000008:administration & dosage / Q000031:analogs & derivatives
D007376:Interleukin-2; C033782:thymosin fraction 5; D006051:Aurothioglucose; D013947:Thymosin