title: Transcriptional regulation of the proC gene of Salmonella typhimurium.
abstract: We found that the expression of beta-galactosidase in Salmonella typhimurium strains carrying proC-lacZ fusions was neither repressed by excess proline nor derepressed by proline limitation. Except for a three- to fourfold decrease in the beta-galactosidase specific activity under conditions causing a severely reduced growth rate, the expression of the proC-lacZ fusions was nearly invariant under a variety of culture conditions. Thus, the proC gene is unlike most other amino acid biosynthetic genes in that its expression is nearly constitutive.
mesh_terms: D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D005798:Genes, Bacterial; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics*; D011392:Proline / Q000096:biosynthesis*; D011762:Pyrroline Carboxylate Reductases / Q000235:genetics*; D012486:Salmonella typhimurium / Q000201:enzymology / Q000235:genetics*; D014158:Transcription, Genetic; D001616:beta-Galactosidase / Q000096:biosynthesis
chemical_list: D011392:Proline; D000587:Oxidoreductases Acting on CH-NH Group Donors; D011762:Pyrroline Carboxylate Reductases; D001616:beta-Galactosidase