Further studies on the intravenously administered fat arteriosclerosis model.
30 rats were divided into 3 experimental groups. These included 8 days of Lipofundin treatment + 8 days recovery period (Group I), 16 days of Lipofundin treatment (Group II), and 16 days of Lipofundin treatment + 8 days recovery period (Group III). After sacrifice semi-thin and ultra-thin sections prepared from the aorta segments were examined light and electron microscopically. In addition to the development of alterations characteristic of the Lipofundin-model, the accumulation of collagen fibres was also observed. After 16 days of Lipofundin treatment the alterations were much more advanced than after 8-day treatment. Subsequent migration of smooth muscle cells through the newly formed internal elastic lamina was apparent and led to thickening of the sclerotic plaque. When the 16-day Lipofundin treatment was followed by a recovery period of 8 days prior to sacrifice, no signs of regression were seen. The alterations were present in unchanged form and the only difference was in the extent of accumulation of collagen fibres.
D000818:Animals; D001011:Aorta / Q000648:ultrastructure*; D001161:Arteriosclerosis / Q000139:chemically induced* / Q000473:pathology; D004195:Disease Models, Animal; D004338:Drug Combinations / Q000008:administration & dosage; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D005990:Glycerol / Q000008:administration & dosage*; D008297:Male; D008854:Microscopy, Electron; D010743:Phospholipids / Q000008:administration & dosage*; D010938:Plant Oils / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D013024:Soybean Oil / Q000008:administration & dosage*
D004338:Drug Combinations; D005217:Fat Emulsions, Intravenous; D010743:Phospholipids; D010938:Plant Oils; C046535:Lipofundin S; D013024:Soybean Oil; D005990:Glycerol