Inhibition of mushroom tyrosinase by 3-amino-L-tyrosine: molecular probing of the active site of the enzyme.
We report the ability of 3-amino-L-tyrosine to act as a fully reversible competitive inhibitor of mushroom tyrosinase. The inhibition is linked to the ortho-aminophenol structure, and a copper bridging mechanism in the active site is proposed.
D001487:Basidiomycota / Q000201:enzymology*; D001665:Binding Sites; D001667:Binding, Competitive; D004156:Catechol Oxidase / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000494:pharmacology
C019253:3-aminotyrosine; D014443:Tyrosine; D004156:Catechol Oxidase; D014442:Monophenol Monooxygenase