Fibrinolytic activity in medium from tissue culture of paranasal mucous membrane.
It is known that a remarkable fibrinolytic activity of plasminogen activator (PA) can be seen in extracts of wet tissue and acetone powder preparation of paranasal mucous membrane evidencing chronic sinusitis. However, the origin of the PA in extract of paranasal mucous membrane has not yet been clarified up to the present time. In this experiment, using a tissue culture of paranasal mucous membrane, it was observed that two species of cells, epithelial cells and fibrocytes, proliferated in the implanted tissue. PA was isolated from the conditioned medium on the fifth day after culture. From these results, it appears that the PA may be released from epithelial cells and/or fibroblasts.
D046508:Culture Techniques; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D005342:Fibrinolysis; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D009092:Mucous Membrane / Q000166:cytology / Q000378:metabolism; D010256:Paranasal Sinuses / Q000166:cytology / Q000378:metabolism*; D010959:Tissue Plasminogen Activator / Q000378:metabolism*
D010959:Tissue Plasminogen Activator