Curing of 60Co gamma-resistance inducing effect of R46 R-factor by 5-fluorouracil.
The 60Co gamma-resistance inducing effect of R46 factor, and its elimination by 5-fluorouracil were studied. R46 increased the survival of the wild-type strain and its rec- mutants. After treatment with 5-fluorouracil (1 g/liter) the clones lost not only antibiotic resistance, but the 60Co gamma-radioresistance as well, encoded by R46 R-factor.
D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D005472:Fluorouracil / Q000494:pharmacology*; D005720:Gamma Rays; D011815:R Factors; D011836:Radiation Tolerance
D005472:Fluorouracil