title: [Immune disorders in hemophiliac patients].
abstract: Hemophiliac patients develop disorders of the immune status as a result of transfusion therapy: a decrease in the number of T-lymphocytes and the ratio T-helpers/T-suppressors resulting from a decrease in the number of T-helpers, enhancement of immunoglobulinogenesis, and an increase in the level of circulating immune complexes. A degree of the above changes depends on a dose and period of the use of antihemophilic drugs. Hemophiliac patients require immunological monitoring, clinical substantiation of doses and a prolonged period of administration of blood preparations.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion; D004306:Dose-Response Relationship, Immunologic; D005169:Factor VIII / Q000008:administration & dosage; D006467:Hemophilia A / Q000150:complications* / Q000276:immunology / Q000628:therapy; D002836:Hemophilia B / Q000150:complications / Q000276:immunology / Q000628:therapy; D006470:Hemorrhage / Q000209:etiology / Q000276:immunology; D006801:Humans; D007154:Immune System Diseases / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D013997:Time Factors
chemical_list: D007136:Immunoglobulins; D005169:Factor VIII
vernacular_title: Immunnye narusheniia u bol'nykh gemofilieĭ.