Glidobactins A, B and C, new antitumor antibiotics. II. Structure elucidation.
The structures of new antitumor antibiotics, glidobactins A (Ia), B (Ib) and C (Ic) were elucidated by a combination of chemical and enzymatic degradations and spectral analyses. They have in common a cyclized tripeptide nucleus composed of L-threonine, 4(S)-amino-2(E)-pentenoic acid and erythro-4-hydroxy-L-lysine, and differ from each other in the unsaturated fatty acid moiety attached to the peptide.
D000596:Amino Acids; D000903:Antibiotics, Antineoplastic; D055598:Chemical Phenomena; D002621:Chemistry; D005227:Fatty Acids; D006868:Hydrolysis; D008239:Lysine / Q000031:analogs & derivatives; D009682:Magnetic Resonance Spectroscopy; D010456:Peptides, Cyclic
D000596:Amino Acids; D000903:Antibiotics, Antineoplastic; D005227:Fatty Acids; D010456:Peptides, Cyclic; C057878:glidobactin A; C057879:glidobactin B; C057880:glidobactin C; D008239:Lysine