Osteocalcin and bone morphometric parameters in adults without bone disease.
Serum bone Gla-protein (s-BGP or osteocalcin) and other serum biochemical parameters were measured in 19 subjects (8 women and 11 men, aged 20-82 years) without any bone disease. Each subject simultaneously underwent an iliac crest biopsy; tetracycline double-labeling was performed in 11 subjects, allowing correlations between s-BGP and bone histomorphometric parameters. s-BGP was significantly correlated with static bone parameters: trabecular bone volume (r = 0.74; P less than 0.001), osteoid surfaces (r = 0.69; P less than 0.001), osteoblastic surfaces (r = 0.68; P less than 0.002); dynamic bone formation parameters: total labeled surfaces (r = 0.72; P less than 0.01); and the bone formation rate (r = 0.69; P less than 0.01). We conclude that s-BGP is a valuable marker for evaluating bone formation in healthy adult subjects.
D000328:Adult; D000368:Aged; D001798:Blood Proteins; D001846:Bone Development; D001851:Bone Diseases, Metabolic / Q000503:physiopathology*; D019485:Bone Morphogenetic Proteins; D001842:Bone and Bones / Q000033:anatomy & histology*; D002135:Calcium-Binding Proteins / Q000032:analysis* / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009024:Morphogenesis; D015675:Osteocalcin; D011506:Proteins / Q000032:analysis*
D001798:Blood Proteins; D019485:Bone Morphogenetic Proteins; D002135:Calcium-Binding Proteins; D011506:Proteins; D015675:Osteocalcin