title: Characterization of enkephalin degradation in rat plasma.
abstract: Approximately 80% of the hydrolysis of [leu]enkephalin in rat plasma can be attributed to bestatin-sensitive aminopeptidase activity, and an additional 5% is due to angiotensin converting enzyme. Thiorphan-sensitive enkephalinase hydrolysis of [leu]enkephalin could not be detected in plasma. On the other hand, 2-d-ala-l-[leu]enkephalin is metabolized approximately 35% by an unidentified bestatin-sensitive enzyme and approximately 15% by thiorphan-sensitive enkephalinase in rat plasma, while captopril-sensitive angiotensin converting enzyme is without measurable activity against this substrate.
mesh_terms: D000626:Aminopeptidases / Q000097:blood*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002216:Captopril / Q000494:pharmacology; D004743:Enkephalin, Leucine / Q000097:blood; D004745:Enkephalins / Q000097:blood*; D007700:Kinetics; D007930:Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D015244:Thiorphan; D008625:Tiopronin / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D004745:Enkephalins; D004743:Enkephalin, Leucine; D002216:Captopril; D015244:Thiorphan; D008625:Tiopronin; D000626:Aminopeptidases; D007930:Leucine; C012211:ubenimex