Plasmacytoma and gastric amyloidosis associated with nodular pulmonary amyloidosis.
The authors report an association of gastric and pulmonary amyloidosis in a 74 year old woman. The patient had had a gastric plasmacytoma for the last 11 years. On autopsy, the stomach was found to contain intramural deposits of amyloid, and was infiltrated by plasma cells secreting monoclonal IgG lambda light chain. In the lungs, the plasma cells in the vicinity of the amyloid deposits proved to be polytypic, suggesting that these deposits originated from circulating precursor proteins.
D000686:Amyloidosis / Q000150:complications* / Q000473:pathology; D001536:Bence Jones Protein / Q000032:analysis; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D008171:Lung Diseases / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D010954:Plasmacytoma / Q000150:complications* / Q000473:pathology; D013272:Stomach Diseases / Q000150:complications* / Q000473:pathology; D013274:Stomach Neoplasms / Q000150:complications* / Q000473:pathology
D007074:Immunoglobulin G; D007146:Immunoglobulin lambda-Chains; D001536:Bence Jones Protein