title: [Outcome more than 10 years later of mechanical mitral valve prostheses in children].
abstract: Between 1966 and 1975, fifty-one children aged from 8 to 15 years underwent mitral valve replacement for mitral valve disease of rheumatismal origin. The mechanical prosthesis was a Starr Edwards 6120 N degrees 2 valve in 48 of the children. Late mortality was 20 p. 100; death was due to valve thrombosis in 3 cases, aortic valve regurgitation in 2 cases and left ventricular dysfunction in 2 cases; it was of unknown origin in 3 cases. Four patients were lost sight of, and 36 have survived up to now with a mean follow-up period of 13 years. The life of these 36 patients has been marked by three types of complication. The first complication was thromboembolic accidents which occurred in 10 patients, were virtually always isolated and regressed completely. The incidence of these accidents was highest in patients treated with antivitamin K irregularly. In 23 patients who did not receive antivitamin K the incidence was only 2.27 thromboembolic accidents per 100 patient-years. The second complication, which affected only 4 patients, was functional stenosis of the prosthesis; it developed very late and was always due to periannular fibrosis either isolated or associated with remodelling of the mitral valve left in situ. The third complication was the development, with or without patent rheumatismal activity, of a lesion of the aortic orifice which required reoperation in 5 cases.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D000925:Anticoagulants / Q000627:therapeutic use; D002648:Child; D003251:Constriction, Pathologic; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000601:surgery; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008943:Mitral Valve; D011247:Pregnancy; D011788:Quality of Life; D012086:Reoperation; D013923:Thromboembolism / Q000209:etiology
chemical_list: D000925:Anticoagulants
vernacular_title: Evolution au-delà de 10 ans des prothèses valvulaires mécaniques en position mitrale chez l'enfant.