Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity.
Antigen-independent cell lines were derived from mouse helper T-cell clones by culture in autologous supernatant obtained after stimulation with concanavalin A. A factor, termed P40, supporting the growth of these lines was purified and characterized as a basic 32- to 39-kDa single-chain glycoprotein functionally distinct from previously identified T-cell growth factors and apparently unrelated structurally to any known protein. Of a number of cell lines, only helper T cells responded to P40, and this response was not mediated by either interleukin 2 or interleukin 4.
D000595:Amino Acid Sequence; D000818:Animals; D006023:Glycoproteins / Q000032:analysis*; D007376:Interleukin-2 / Q000494:pharmacology; D015847:Interleukin-4; D016906:Interleukin-9; D007378:Interleukins / Q000032:analysis* / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D008970:Molecular Weight; D013601:T-Lymphocytes / Q000187:drug effects*
D006023:Glycoproteins; D007376:Interleukin-2; D016906:Interleukin-9; D007378:Interleukins; D015847:Interleukin-4