Paraproteinemia in a case of mixed-cellularity Hodgkin's disease.
A man with histologically unequivocal mixed-cellularity Hodgkin's disease, stage IVB, developed an IgG lambda paraproteinemia with bone marrow plasmocytosis but without any other evidence of multiple myeloma. This unusual finding is discussed in the context of recent data suggesting a B-cell origin for some cases of Hodgkin's disease as well as in relation to the evidence of immunoregulatory disturbances in this entity.
D001402:B-Lymphocytes / Q000502:physiology; D006689:Hodgkin Disease / Q000150:complications* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007146:Immunoglobulin lambda-Chains / Q000032:analysis*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications*
D007074:Immunoglobulin G; D007146:Immunoglobulin lambda-Chains