[Dynamics of endogenous bacterial nitrite formation in the stomach. 2. Follow-up observations with standardized secretion from the porcine stomach].
The bacterial nitrite synthesis in gastric juice from porcine stomach mucin and the decrease of nitrite after adding acid, which has often been described in literature-results of an examination with a standardizable biomodel. A decrease of nitrite concentration was only seen after adding a small volume acid of high concentration. Simulating the acid secretion by a large volume of low concentrated acid mixed with pepsin-solution (artificial gastric secrete, DAB 8) a considerable increase of nitrite concentration can be observed. An explanation can be the structure of stomach mucous gel can be solubilized in water and thus the ions are liberized inside of the stomach mucin. In the discussion of the endogenous synthesis of cancerogenic N-Nitroso-compounds it must be considered if this phenomena also can be observed in human secretes.
D000818:Animals; D001419:Bacteria / Q000254:growth & development / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006851:Hydrochloric Acid / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008954:Models, Biological; D009566:Nitrates / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism*; D010434:Pepsin A / Q000494:pharmacology; D013270:Stomach / Q000382:microbiology; D013552:Swine
D009566:Nitrates; D009573:Nitrites; D010434:Pepsin A; D006851:Hydrochloric Acid
Dynamik der endogenen bakteriellen Nitritbildung im Magen. 2. Mitteilung: Verlaufsbeobachtung mit standardisiertem Sekret des Schweinemagens.