Recovery from immunesuppression in mice infected with Schistosoma japonicum by treatment of praziquantel.
To learn the possible alteration of immune response, hemolytic plaque-forming cells (PFC) produced in the spleen of Schistosoma japonicum infected mice treated with Praziquantel and untreated group were counted. There was no significant difference in the immunesuppression percentage between the treated and untreated groups 1 and 3 weeks after treatment. In 5 weeks after treatment, however, the immunesuppression percentage in the treated mice was markedly reduced in comparison with that of the untreated group. Recovery from immunesuppression appears to be associated with elimination or impairment of adult worms.
D000818:Animals; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance / Q000187:drug effects*; D051379:Mice; D010270:Parasite Egg Count; D011223:Praziquantel / Q000627:therapeutic use*; D012549:Schistosoma japonicum / Q000302:isolation & purification; D012554:Schistosomiasis japonica / Q000188:drug therapy* / Q000276:immunology / Q000469:parasitology; D013997:Time Factors
D011223:Praziquantel