Activated T lymphocytes in patients with multiple sclerosis in clinical remission.
Activation state and proliferation of lymphocytes of 6 patients with definite multiple sclerosis in clinical remission were studied. Lymphocytes carrying MHC class II coded Ia antigen, glycoprotein gp 40/80 and interleukin-2 receptor were significantly higher in patients with MS in remission than in normal healthy controls. The entrance of T cells into the G1 and S phase of the cell cycle was studied using [3H]thymidine autoradiography in combination with immunocytochemistry (cell markers). The proportion of T cells in the S phase of the cell cycle in the peripheral blood was similar in the MS patient and in the control group.
D001345:Autoradiography; D002455:Cell Division; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008213:Lymphocyte Activation; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology* / Q000503:physiopathology; D011971:Receptors, Immunologic / Q000032:analysis; D015375:Receptors, Interleukin-2; D012075:Remission, Spontaneous; D013601:T-Lymphocytes / Q000032:analysis* / Q000166:cytology; D013936:Thymidine
D000949:Histocompatibility Antigens Class II; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D013936:Thymidine