title: Carbon dioxide laser effect on platelet function and surface ultrastructure in vitro.
abstract: Platelet aggregation may be an important factor in the feasibility of transcatheter laser angioplasty. The in vitro effects of increasing doses of CO2 laser irradiation on platelet number, function, and surface ultrastructure were examined. Results indicated a progressive dose-response reduction of both platelet number and function following laser irradiation. By scanning electron microscopy the irradiated platelets showed dose-related changes in pseudopods as well as progressive damage of the cell membrane.
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000502:physiology / Q000528:radiation effects* / Q000648:ultrastructure; D002245:Carbon Dioxide; D002462:Cell Membrane / Q000528:radiation effects / Q000648:ultrastructure; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007834:Lasers; D008855:Microscopy, Electron, Scanning; D010974:Platelet Aggregation / Q000528:radiation effects; D010976:Platelet Count / Q000528:radiation effects
chemical_list: D002245:Carbon Dioxide