The role of combined surgery and radiotherapy in the management of stage I and II carcinoma of the cervix.
The results are presented of 100 patients with stage I B, II A or II B carcinoma of the cervix treated by combined surgery and radiotherapy. The actuarial five year survival rates for FIGO stage I B (74 patients) was 85%, for selected stage II A (8 patients) 100%, and for selected early stage II B (18 patients) 72%. Within FIGO stage I B the five year survival for patients with negative nodes was 93% and for those with positive nodes 36%. The radiotherapy complication rate for patients treated with pre-operative radiotherapy followed by Wertheim's hysterectomy was 5%. However, when additional post-operative radiotherapy was given, the complication rate was 60%. It is concluded that pre-operative intracavitary radiotherapy followed by Wertheim's hysterectomy is suitable treatment for early-stage disease with negative nodes, but is unsatisfactory treatment for poor risk patients requiring additional post-operative radiotherapy, as their survival rate is poor and the complication rate is high.
D000206:Actuarial Analysis; D001918:Brachytherapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D011882:Radiotherapy, High-Energy; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000628:therapy*