[Preparation and schistosomicidal activity of vinylogues of 1,3-dithio-3-thione].
The synthesis of vinylogues of 1,2-dithiol-3-thione is described. The activity in experimental schistosomiasis (schistosomicidal activity and, for the most interesting ones, on the egg-laying) was tested in mice with Schistosoma mansoni in comparison with oltipraz.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012555:Schistosomiasis mansoni / Q000188:drug therapy; D012556:Schistosomicides / Q000138:chemical synthesis*; D013871:Thiones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D014753:Vinyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use
D012556:Schistosomicides; D013871:Thiones; D014753:Vinyl Compounds
Préparation et activité schistosomicide de vinylogues de dithiole-1,2 thiones-3.