Lipoxygenase metabolites as mediators of platelet activating factor-induced increased airways responsiveness to histamine in the guinea-pig.
Inhibitors of platelet activating factor (PAF) and leukotriene synthesis or action are of interest as potential anti-asthmatic drugs. The present study outlines evidence suggesting an interaction between PAF and lipoxygenase products mediating increased airways responsiveness to histamine in vivo.
D000818:Animals; D001249:Asthma / Q000188:drug therapy; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D020024:Leukotriene Antagonists; D015289:Leukotrienes / Q000096:biosynthesis; D008084:Lipoxygenase / Q000378:metabolism*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000502:physiology; D012137:Respiratory System / Q000187:drug effects*
D020024:Leukotriene Antagonists; D015289:Leukotrienes; D010972:Platelet Activating Factor; D006632:Histamine; D008084:Lipoxygenase