Stimulation of neutrophil respiratory burst and lysosomal enzyme release by human interferon-gamma.
Highly purified human interferon-gamma (IFN-gamma) induced a respiratory burst and lysosomal enzyme release in human neutrophils. The lymphokine augmented the respiratory burst induced by phorbol myristate acetate (PMA), or N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP), and increased the release of specific granule enzymes induced by opsonized zymosan. Viability and locomotion of neutrophils were unaffected by IFN-gamma.
D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D007371:Interferon-gamma / Q000494:pharmacology*; D008247:Lysosomes / Q000201:enzymology; D009504:Neutrophils / Q000201:enzymology / Q000378:metabolism*
D007371:Interferon-gamma; D006861:Hydrogen Peroxide