Effect of an aldose reductase inhibitor, AL-1576, on the development of UV-B and X-ray cataract.
The effect of an aldose reductase inhibitor, AL-1576, on the development of UV-B and X-ray-induced cataract was studied with 100 female Brown-Norway rats. Histological studies were made with 32 eyes. A new histological procedure enabled detailed information on UV or X-ray-induced impairment on the lens, as well as on the potential efficiency of anticataract drugs. No definite effect of the aldose reductase inhibitor, AL-1576, on the development of UV or X-ray-induced cataract could be found. It may be concluded that AL-1576 cannot prevent damage caused by irradiation, like that of other oxidative influences. Disadvantageous effects of AL-1576 on the lens could be excluded.
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002386:Cataract / Q000209:etiology* / Q000473:pathology; D005260:Female; D005449:Fluorenes / Q000494:pharmacology*; D006827:Hydantoins / Q000494:pharmacology*; D007908:Lens, Crystalline / Q000473:pathology / Q000528:radiation effects; D011833:Radiation Injuries, Experimental; D051381:Rats; D011919:Rats, Inbred Strains; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*; D014466:Ultraviolet Rays
D005449:Fluorenes; D006827:Hydantoins; C052241:imirestat; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase