Elevations in thyroid-stimulating hormone in normal subjects after receiving short-term lithium carbonate.
Nine normal, healthy male subjects had significantly elevated thyroid-stimulating hormone (TSH) concentrations while receiving oral lithium carbonate for two weeks. The mean minimum lithium serum concentration was 0.765 mEq/L. The TSH concentrations after 15 days on lithium were significantly correlated to the TSH concentration at baseline. No correlation was found between mean minimum lithium steady-state concentration and TSH concentration after 15 days on lithium. Further research is necessary to determine if a high baseline TSH concentration or an early rise in TSH will predict those patients who will eventually develop hypothyroidism after long-term lithium therapy.
D000328:Adult; D006801:Humans; D008094:Lithium / Q000009:adverse effects*; D016651:Lithium Carbonate; D008297:Male; D013972:Thyrotropin / Q000097:blood*; D013997:Time Factors
D016651:Lithium Carbonate; D013972:Thyrotropin; D008094:Lithium