A synthetic adjuvant effective in inducing antitumor immunity.
Guinea pigs which were injected repeatedly with a mixture of a 3M KCl extract of line 10 tumor and 6-O-(2-tetradecyl-hexadecanoyl)-muramyl-dipeptide (B30-MDP) rejected a tumor graft of line 10. Such an adjuvant effect of B30-MDP was also demonstrated when X-ray-treated line 10 cells were mixed with B30-MDP dissolved in phosphate-buffered saline and inoculated into the animals.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D008081:Liposomes / Q000008:administration & dosage; D009374:Neoplasms, Experimental / Q000276:immunology*; D014612:Vaccines / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000951:Antigens, Neoplasm; D008081:Liposomes; D014612:Vaccines; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C044706:B 30-muramyl dipeptide