Morphine metabolism in mouse brain.
Morphine UDP-glucuronyltransferase activity was demonstrated in the brain of mice from recombinant inbred strains of the BXD series. The formation rate of morphine-3-glucuronide was about 4 fold higher in the progenitor DBA as compared to the C57BL strain.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002851:Chromatography, High Pressure Liquid; D003433:Crosses, Genetic; D005965:Glucuronates / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D008861:Microsomes / Q000201:enzymology*; D009020:Morphine / Q000378:metabolism*; D011995:Recombination, Genetic
D005965:Glucuronates; D009020:Morphine; D014453:Glucuronosyltransferase