The IL-2 receptor beta chain (p70): role in mediating signals for LAK, NK, and proliferative activities.
Interleukin-2 (IL-2) induces cytolytic activity and proliferation of human blood lymphocytes. Yet, prior to activation, these cells do not express IL-2 receptors recognized by monoclonal antibodies to the Tac antigen. A novel glycoprotein (IL-2R beta), identified on several lymphocytoid cell lines, has the ability to bind IL-2 alone and to associate with Tac antigen (IL-2R alpha) to form high-affinity IL-2 receptors. It is now reported that IL-2R beta is expressed on both circulating T lymphocytes and large granular lymphocytes in quantities approximately proportional to their responsiveness to IL-2. Studies of the responses of these cells to IL-2 suggest that IL-2R beta mediates the initial phase of induction of lymphokine activated killer (LAK), natural killer (NK), and proliferative activities. Subsequently, IL-2R alpha is induced and functional high-affinity IL-2 receptors are expressed.
D000911:Antibodies, Monoclonal; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000145:classification; D008222:Lymphokines / Q000502:physiology*; D046911:Macromolecular Substances; D011971:Receptors, Immunologic / Q000502:physiology*; D015375:Receptors, Interleukin-2; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D008222:Lymphokines; D046911:Macromolecular Substances; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2