[Correlation of skin tests and the production of gamma-interferon in leprosy patients].
The responsiveness of 25 leprosy patients to an in vitro correlate of cell-mediated immunity to M. leprae antigen, (the production of Y-IFN by peripheral blood mononuclear cells) was compared to their response to skin tests routinely used to evaluate cell-mediated immunity to a number of antigens including M. leprae. The results indicate that among the polar lepromatous patients (LL) there was a clear correlation between low responses in the in vitro assay (Y-IFN production), negative skin test to the specific antigen (Mitsuda reaction) and low responses to skin tests to a related antigen (PPD). There was no correlation in the other clinical groups with skin tests to other unrelated antigens.
D000942:Antigens, Bacterial / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D007918:Leprosy / Q000276:immunology* / Q000378:metabolism; D009166:Mycobacterium leprae / Q000276:immunology*; D012882:Skin Tests
D000942:Antigens, Bacterial; D007371:Interferon-gamma
Correlação entre testes cutâneos e produção de Y-IFN en pacientes com hanseníase.