A monoclonal antibody that recognizes a common antigen in myeloid and human T-cell leukemia virus type I-carrying cells.
A novel monoclonal antibody, designated D-213, was generated to human myeloid cell line PL-21. D-213 defined a 47-kD antigen which was specifically expressed in normal and leukemic cells of the myeloid lineage and in T-cell lines carrying human T-cell leukemia virus type I. This antibody was also reactive with adult T-cell leukemia/lymphoma (ATLL) cells in formalin-fixed, paraffin-embedded tissues. D-213 would be useful for making an immunohistochemical diagnosis of ATLL in cases where serological or virological information is not available.
D000818:Animals; D000911:Antibodies, Monoclonal; D001853:Bone Marrow / Q000276:immunology*; D002460:Cell Line; D015486:HTLV-I Antigens / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C
D000911:Antibodies, Monoclonal; D015486:HTLV-I Antigens