Selective immunodeficiency with defect in interferon-gamma induction in two sibs with recurrent infections.
Phytohaemagglutinin induces interferon-gamma synthesis in lymphocyte cultures from healthy individuals. We report two sibs with recurrent infections, selective IgA deficiency, and reduced blast transformation index under PHA-stimulation, without interferon-gamma response.
D000293:Adolescent; D001752:Blast Crisis; D005260:Female; D006801:Humans; D017098:IgA Deficiency; D007153:Immunologic Deficiency Syndromes / Q000097:blood / Q000150:complications / Q000235:genetics*; D007239:Infections / Q000209:etiology*; D007371:Interferon-gamma / Q000096:biosynthesis*; D008214:Lymphocytes / Q000378:metabolism; D008297:Male
D007371:Interferon-gamma