title: Species variation in gastric toxicity following chronic administration of ciprofibrate to rat, mouse, and marmoset.
abstract: Comparative oral toxicity studies with ciprofibrate have been undertaken in the mouse, rat, and marmoset for up to 26 weeks. Chronic administration of ciprofibrate (20 mg/kg/day) produced a prolonged, modest, but statistically significant hypergastrinemia in the rat. Morphological changes in the rat stomach included increased eosinophilia and hypertrophy of oxyntic cells after 2 or more weeks treatment and hyperplasia of the neuroendocrine (NE) cells after 8 weeks treatment. In contrast, only a transient hypergastrinemia was induced, but not sustained in the mouse at the same dose level over an 8-week time period. No morphological changes were detected in the stomach of this species. In the marmoset treatment, up to 80 mg/kg/day for 26 weeks failed to induce hypergastrinemia and no significant alterations in gastric NE cells were detected.
mesh_terms: D000818:Animals; D002143:Callitrichinae; D002994:Clofibrate / Q000031:analogs & derivatives*; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D058607:Fibric Acids; D005755:Gastrins / Q000097:blood; D008297:Male; D051379:Mice; D051381:Rats; D011916:Rats, Inbred F344; D013045:Species Specificity; D013270:Stomach / Q000187:drug effects* / Q000473:pathology
chemical_list: D058607:Fibric Acids; D005755:Gastrins; D002995:Clofibric Acid; C019304:ciprofibrate; D002994:Clofibrate