title: Effect of verapamil on platelet surface ultrastructure and calcium content.
abstract: The effect of verapamil on the surface ultrastructure and calcium content of human platelets was studied by scanning electron microscopy and X-ray microanalysis. The results showed that the drug prevents platelet pseudopodia formation and causes a dose-dependent inhibition of platelet calcium concentration. The significance of these findings in the explanation of the inhibitory effect of verapamil on platelet aggregation is discussed.
mesh_terms: D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D002118:Calcium / Q000037:antagonists & inhibitors*; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D011554:Pseudopodia / Q000187:drug effects / Q000648:ultrastructure; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D014700:Verapamil; D002118:Calcium