A permissive effect of cyclosporin on the development of isohaemagglutinins of graft origin in ABO-mismatched organ transplantation.
Acquired immunhaemolytic anemia is a rare but potentially hazardous phenomenon in ABO-mismatched allograft recipients. We report on a further patient, in whom severe haemolytic anemia developed due to a highly specific anti-A1 'auto' antibody of IgG class, after receiving an ABO-mismatched kidney graft. The possible role of immunosuppressive medication in the generation and limitation of this immune disease is discussed.
D000017:ABO Blood-Group System / Q000276:immunology; D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology / Q000276:immunology*; D001323:Autoantibodies / Q000096:biosynthesis*; D003520:Cyclophosphamide / Q000276:immunology; D003524:Cyclosporins / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007668:Kidney / Q000276:immunology*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged
D000017:ABO Blood-Group System; D001323:Autoantibodies; D003524:Cyclosporins; D007074:Immunoglobulin G; D003520:Cyclophosphamide