title: In vitro analysis of T-cell-mediated immunity to intact eggs in murine experimental Schistosoma japonicum infection.
abstract: To characterize the mechanisms of induction and regulation of the cell population involved in granuloma formation around eggs of Schistosoma japonicum, we utilized a simple method of in vitro experiments. Lyt1+2-T cells were essential for in vitro responses to the intact S. japonicum eggs, which were assumed to be comparable to in vivo granulomatous responses. T-cell responses seemed to be macrophage-dependent, and responding T cells produced IL-2-like activities in the culture supernatant. Sera taken from chronically infected mice acted as regulatory factors to these T-cell responses as was the case in in vivo granuloma formation. The method used here was simple and highly informative for the studies on pathogenesis of schistosomiasis japonica.
mesh_terms: D000818:Animals; D006099:Granuloma / Q000209:etiology / Q000276:immunology; D007111:Immunity, Cellular; D008222:Lymphokines / Q000096:biosynthesis; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010063:Ovum / Q000276:immunology; D012549:Schistosoma japonicum / Q000276:immunology*; D012554:Schistosomiasis japonica / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D013997:Time Factors
chemical_list: D008222:Lymphokines