The role of interleukin 2 (IL 2) in the proliferation of Theileria annulata-infected bovine lymphocytes.
The role of interleukin 2 (IL 2) in the proliferation of Theileria annulata-infected lymphoblastoid cells was studied. It was found that these cells neither require nor produce IL 2. This was based on the following findings: (a) The growth of T. annulata-infected cells was not enhanced by addition of IL 2 to the culture medium. (b) IL 2-dependent Con A-stimulated bovine peripheral blood lymphocytes (Con A-blasts) no longer required IL 2 after being infected with sporozoites of T. annulata. (c) The supernatants of T. annulata-infected cells did not support growth of IL 2-dependent Con A-blasts.
D000818:Animals; D016782:Apicomplexa / Q000502:physiology*; D002417:Cattle; D003208:Concanavalin A; D007376:Interleukin-2 / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology / Q000469:parasitology*; D013801:Theileriasis / Q000469:parasitology
D007376:Interleukin-2; D003208:Concanavalin A