[Selective effect of ligands on AT- and GC-pairs of DNA bases].
A method is proposed for investigating the specific influence of ligands on DNA AT- and GC-pairs based on the comparison of the width of transition temperature interval of DNA with a strongly pronounced block-structure and dependence of the control DNA melting temperature on their GC-content. Such a comparison allows to define separately the contribution of nonspecific effects causing a change of the width of transition temperature interval. The method is used for studying the specific influence of beta-alanine and nu-aminobutyric acid on AT- and GC-pairs.
D000818:Animals; D001482:Base Composition / Q000187:drug effects*; D002152:Calorimetry, Differential Scanning; D002417:Cattle; D008024:Ligands / Q000494:pharmacology*; D015091:beta-Alanine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D008024:Ligands; D015091:beta-Alanine; D005680:gamma-Aminobutyric Acid
Izbiratel'noe vliianie ligandov na AT- i GTs-pary osnovaniĭ DNK.