Concurrent lupus anticoagulants and prothrombin deficiency due to phenytoin use.
A man with lupus anticoagulant and a prothrombin deficiency was studied before and after cessation of treatment with phenytoin. Multiple abnormal laboratory values of the following partially or completely resolved after the patient's therapy was discontinued: tissue thromboplastin inhibition ratio, prothrombin time, activated partial thromboplastin time, anticardiolipin antibodies, and quantitative measures and abnormal pattern on crossed immunoelectrophoresis of prothrombin. This patient represented an example of a concurrent drug-induced prothrombin deficiency and a lupus anticoagulant.
D000328:Adult; D001778:Blood Coagulation Disorders / Q000139:chemically induced*; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology*; D001780:Blood Coagulation Tests; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D007020:Hypoprothrombinemias / Q000139:chemically induced*; D007123:Immunoelectrophoresis, Two-Dimensional; D016682:Lupus Coagulation Inhibitor; D008297:Male; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D011516:Prothrombin / Q000032:analysis
D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor; D010672:Phenytoin; D011516:Prothrombin