Temperature-dependent expression of the chromosomal beta-lactamase gene in a strain of Pseudomonas aeruginosa.
A strain of Pseudomonas aeruginosa (3-Post) was resistant to cefsulodin and ceftazidime at 37 degrees C but sensitive at 20 degrees C. Resistance was mediated by chromosomally-encoded beta lactamase which was synthesised at a high level during growth above 30 degrees C but at a low, inducible level during growth below 27 degrees C.
D002441:Cefsulodin / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology; D002511:Cephalosporins / Q000378:metabolism; D002876:Chromosomes, Bacterial / Q000502:physiology; D004352:Drug Resistance, Microbial; D005786:Gene Expression Regulation; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D013696:Temperature; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
D002511:Cephalosporins; C025163:cephalosporin C; D002442:Ceftazidime; D001618:beta-Lactamases; D002441:Cefsulodin