title: Lymphotoxin-induced growth stimulation of diploid human fibroblasts in the presence and absence of gamma interferon.
abstract: In the present study we investigated the effect of lymphotoxin (LT) on the growth of human diploid fibroblasts, in the presence and absence of gamma interferon (IFN-gamma). Recombinant LT (rLT) had a growth stimulatory effect on diploid human FS-4 fibroblasts. This growth-stimulatory effect was reduced in the presence of recombinant IFN-gamma (rIFN-gamma). LT thus has a similar effect on diploid fibroblasts as tumour necrosis factor (TNF).
mesh_terms: D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008233:Lymphotoxin-alpha / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D008233:Lymphotoxin-alpha; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma