Low TRH-TSH responses in human essential hypertension.
Thirty female and male essential hypertensive patients and eighteen normotensive controls were submitted to the TRH-TSH conventional test (200 ug intravenously, bolus injection of TRH). Supramaximal doses of 400 and 600 ug were repeated with a week interval to each subject. Hypertensives showed a significant lower response to both conventional and supramaximal TRH doses. Hypothalamic-pituitary-thyroid axis abnormalities, secondary to TRH-receptor alterations, could account for this result.
D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000187:drug effects; D012737:Sex Factors; D013972:Thyrotropin / Q000096:biosynthesis* / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin