Effect of 5-hydroxytryptophan on H-reflex recovery curves in normal subjects and patients with affective disorders.
The effect of the serotonin precursor DL-5-hydroxytryptophan (5-HTP) on the Hoffmann reflex recovery curve (HRRC) was studied in normal subjects and patients with affective illness. 5-HTP significantly decreased the HRRC in normal controls and in depressed and manic patients receiving treatment with lithium or antidepressants. 5-HTP increased the HRRC in unmedicated depressed and manic patients. These results provide further evidence for a serotonergic abnormality in the affective disorders.
D006916:5-Hydroxytryptophan / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D001143:Arousal / Q000187:drug effects; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D001921:Brain / Q000187:drug effects; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006181:H-Reflex / Q000187:drug effects*; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000523:psychology; D011930:Reaction Time / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012023:Reflex, Monosynaptic / Q000187:drug effects*
D000928:Antidepressive Agents; D011985:Receptors, Serotonin; D016651:Lithium Carbonate; D008094:Lithium; D006916:5-Hydroxytryptophan