Histiocytosis X Langerhans cells react with antiinterleukin-2 receptor monoclonal antibody.
Immunohistochemical study of 7 cases of histiocytosis X (HX) and of histologically normal skin shows that HX Langerhans cells react with Bl.49.9 monoclonal antibody which recognizes the Interleukin-2 receptor, whereas normal skin Langerhans cells do not. This reactivity suggest activation of HX Langerhans cells.
D000911:Antibodies, Monoclonal / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006646:Histiocytosis, Langerhans-Cell / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007376:Interleukin-2; D007801:Langerhans Cells / Q000276:immunology*; D011971:Receptors, Immunologic / Q000032:analysis*; D015375:Receptors, Interleukin-2; D012867:Skin
D000911:Antibodies, Monoclonal; D007376:Interleukin-2; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2