Isolation of Neisseria meningitidis strains with increase of penicillin minimal inhibitory concentrations.
We report the isolation and characterization of ten strains showing an increase in the minimal inhibitory concentrations to penicillin (MICs greater than 0.1 microgram/ml), and describe the epidemiological, clinical and microbiological features. The susceptibility of 3432 meningococcal strains isolated from patients in the recent epidemic wave (1978-86) in Spain, to several antimicrobial agents used in the treatment and chemoprophylaxis of meningococcal infection has been tested. Most were resistant to sulphadiazine but sensitive to other antibiotics. The possible existence of a new pattern of behaviour of meningococcal to penicillin is discussed.
D000368:Aged; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008585:Meningitis, Meningococcal / Q000382:microbiology*; D008589:Meningococcal Infections / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D009345:Neisseria meningitidis / Q000187:drug effects* / Q000302:isolation & purification; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D013030:Spain; D013411:Sulfadiazine / Q000494:pharmacology*
D010406:Penicillins; D013411:Sulfadiazine