[Ultrastructural changes in synaptic junctions of the mouse neocortex during rehabilitation after prolonged protein-calorie malnutrition].
The quantitative ultrastructural study of neocortical synaptic junctions has been performed during rehabilitation after protein-caloric deficiency. It has been shown that simple food rehabilitation does not lead to absolute restoration of synaptic junctions. However, food rehabilitation with carnitine restores the ultrastructure of synaptic junctions, with the length of the active zones and the number of spine apparatus cisterns exceeding the control values. Nevertheless, synaptic cleft width and postsynaptic density remain lower than in the control group, both after simple food rehabilitation and food rehabilitation with carnitine.
D000818:Animals; D002331:Carnitine / Q000008:administration & dosage; D002540:Cerebral Cortex / Q000648:ultrastructure*; D004044:Dietary Proteins / Q000008:administration & dosage; D007365:Intercellular Junctions / Q000648:ultrastructure*; D051379:Mice; D008808:Mice, Inbred CBA; D011502:Protein-Energy Malnutrition / Q000473:pathology / Q000534:rehabilitation*; D013569:Synapses / Q000648:ultrastructure*
D004044:Dietary Proteins; D002331:Carnitine
Ultrastrukturnye izmeneniia sinapticheskikh kontaktov neokorteksa mysheĭ v protsesse reabilitatsii posle dlitel'noĭ belkovo-énergeticheskoĭ nedostatochnosti.