Inhibitory effects of fungi on aggregation of rabbit platelets and rat polymorphonuclear leucocytes in vitro.
Fungi of six families, encompassing 28 species, have been screened for their inhibitory effects on adenosine-5'-diphosphate (ADP), acetyl-glyceryl-phosphorylcholine (PAF) or collagen-induced rabbit platelet aggregation. Some fungi have also been studied for their ability to inhibit neutrophil aggregation induced by calcium ionophore A 23187. The results suggest that fungi may be a potential source of inhibitors of platelet and neutrophil aggregation.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002449:Cell Aggregation / Q000187:drug effects; D003094:Collagen / Q000494:pharmacology; D003956:Dialysis; D005612:Freeze Drying; D005658:Fungi / Q000032:analysis / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009504:Neutrophils / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits
D000001:Calcimycin; D000244:Adenosine Diphosphate; D003094:Collagen