Haemophilia A in German shepherd dogs.
Haemophilia A was diagnosed in 14 male German shepherd dogs. Factor VIII: coagulant (FVIII:C) activities ranged from 1.13% of a normal canine plasma pool. von Willebrand's factor antigen values were normal or increased in all 9 of these dogs which were tested. Twelve of these dogs had a common maternal grandsire. Five dogs had exhibited no tendency to bleed (when tested between 2 to 23 months of age). They were tested because of pedigree links with clinically affected animals. Common clinical signs in the latter dogs included: bleeding from the mouth, subcutaneous and intramuscular haematomas and lameness. Since these dogs usually had a mild to moderate deficiency of FVIII:C, they may survive to adulthood without exhibiting clinical signs severe enough to necessitate veterinary attention.
D000818:Animals; D000941:Antigens / Q000032:analysis; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D004285:Dogs; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006467:Hemophilia A / Q000097:blood / Q000175:diagnosis / Q000235:genetics / Q000662:veterinary*; D008297:Male; D010314:Partial Thromboplastin Time / Q000662:veterinary; D010375:Pedigree; D011517:Prothrombin Time / Q000662:veterinary; D014841:von Willebrand Factor / Q000276:immunology
D000941:Antigens; D014841:von Willebrand Factor; D005169:Factor VIII