title: Genotoxic effects of fluoride: a controversial issue.
abstract: Fluoride is an element which is widely distributed in our environment. Its cariostatic efficacy has been well documented, and numerous studies indicate that at a concentration of 1 ppm in water, fluoride is beneficial for caries prevention and does not appear to exacerbate any diseases. Currently, more than half the American population is consuming naturally or artificially fluoridated water and efforts are being made to increase this proportion significantly. In addition, the multiple use of fluoride for dental caries prevention is clearly increasing. It is a common practice to use fluoride in a variety of delivery systems, including dentifrices, mouthrinses, pediatric supplements, and professional or self-applied topical solutions or gels as well as dental restorative materials. These dental products may contain fluoride in concentrations as high as 12,300 ppm. Increasing exposure of the population to fluoride has raised questions about the safety of this measure and has established the need for objective reappraisal. In particular, interest has developed regarding the genotoxic effects of fluoride. Unfortunately, there is, at present, only a limited amount of information available concerning the potential genotoxic effects of fluoride, and the results that have been published are contradictory and often very confusing. A review of the literature clearly indicates the importance of, and necessity for, clarifying the conflicts and controversies regarding this important issue.
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000187:drug effects*; D004249:DNA Damage; D004331:Drosophila melanogaster / Q000187:drug effects; D005459:Fluorides / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens; D012475:Salmonella / Q000187:drug effects
chemical_list: D009153:Mutagens; D005459:Fluorides