[Transplantation of the superior cervical ganglion into the brain--a new experimental therapy of Parkinson disease].
To supplement catecholamine deficit in the brain with Parkinson disease, we have aimed to transplant the superior cervical ganglion (SCG), which contains norepinephrine and dopamine, into the brain. 1. Transplantation of SCG into rat cerebral cortex SCG was transplanted into the same rat's parietal cortex. Three weeks after the transplantation, catecholamine histofluorescence revealed many transplanted catecholamine cells in the cortex. However, no fibers extended from the transplanted tissue to the cerebral cortex. Some catecholamine fibers extended to the cerebral cortex where 6-OHDA (a specific neurotoxin to the catecholamine neuron) had been pretreated. 2. Transplantation of SCG into the caudate nucleus of MPTP-induced Parkinson monkey For animal model of Parkinson disease, MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine) was administered to 5 monkeys. Tow weeks after MPTP administration, dopamine terminals disappeared in the caudate nucleus. After transplantation of SCG in the same animal, many transplanted SCG cells extended their axons to the caudate nucleus. The present results showed that transplanted SCG cells were well survived in the brain. Under a special circumstance such as shortage of catecholamine in the brain, transplanted SCG cells extended their axons into the brain. It is suggested that the transplantation of SCG can be a new therapy for Parkinson disease.
D000818:Animals; D001921:Brain / Q000601:surgery*; D002395:Catecholamines / Q000378:metabolism; D002421:Caudate Nucleus / Q000601:surgery; D002540:Cerebral Cortex / Q000601:surgery; D005728:Ganglia, Sympathetic / Q000378:metabolism / Q000637:transplantation*; D000882:Haplorhini; D009412:Nerve Fibers / Q000378:metabolism; D010300:Parkinson Disease / Q000378:metabolism / Q000628:therapy*; D051381:Rats; D011919:Rats, Inbred Strains
D002395:Catecholamines