Loss of adhesion. A novel and distinct effect of the cytotoxic T lymphocyte-target interaction.
The ability of adherent target cells to remain attached to their substratum is lost as an early consequence of interaction with cytotoxic T lymphocytes. This phenomenon is shown to be a distinct event in the lytic process induced by cytotoxic T lymphocytes and does not occur during lysis by antibody plus complement. Thus loss of adhesion represents a previously unrecognized form of immune damage which may have important implications in both normal and pathologic responses.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002448:Cell Adhesion / Q000187:drug effects; D002450:Cell Communication / Q000187:drug effects; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic / Q000379:methods; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004533:Egtazic Acid / Q000494:pharmacology; D005347:Fibroblasts / Q000276:immunology / Q000502:physiology; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000378:metabolism / Q000502:physiology*
D004533:Egtazic Acid; D002118:Calcium