Effects of indomethacin and diclofenac on cerebral blood flow in hypercapnic conscious rats.
Cerebral blood flow (CBF) was measured in conscious rats treated with indomethacin, diclofenac or the vehicle for indomethacin during hypercapnia of three different degrees. Similar values were found for CBF in rats treated with diclofenac or vehicle and there was a direct correlation between CBF and the arterial blood carbon dioxide values. In contrast, indomethacin completely blocked the increase of CBF during hypercapnia. These results suggest strongly that prostaglandins are not involved in the hypercapnia-induced cerebral vasodilatation.
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004008:Diclofenac / Q000494:pharmacology*; D006935:Hypercapnia / Q000503:physiopathology*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002245:Carbon Dioxide; D004008:Diclofenac; D007213:Indomethacin