A comparison of the acute effect of single doses of vigabatrin and sodium valproate on photosensitivity in epileptic patients.
The acute effect of oral administration of a single dose of vigabatrin, a new antiepileptic drug which acts by irreversible enzyme-activated inhibition of the brain enzyme, GABA-aminotransferase, on the photoconvulsive response in patients with photosensitive epilepsy, was compared with that of the established antiepileptic drug, sodium valproate. Both drugs significantly suppressed the photoconvulsive response in 3 out of 6 subjects. This result was interpreted as further evidence of vigabatrin's potential value in the future treatment of patients with epilepsy.
D000293:Adolescent; D000328:Adult; D000614:Aminocaproates / Q000627:therapeutic use*; D002648:Child; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008027:Light; D013997:Time Factors; D014635:Valproic Acid / Q000627:therapeutic use*; D020888:Vigabatrin; D014795:Visual Pathways / Q000502:physiology*
D000614:Aminocaproates; D004791:Enzyme Inhibitors; D014635:Valproic Acid; D020888:Vigabatrin