In vitro activity of sulphamethoxazole/trimethoprim and sulfadoxine/pyrimethamine against Chlamydia trachomatis SA2f in McCoy cell culture.
Chequerboard titrations of sulphamethoxazole/trimethoprim and sulfadoxine/pyrimethamine were performed against Chlamydia trachomatis (strain SA2f) using McCoy cell monolayers in vials. The experiments were continued for ten passages each. The mean fractional inhibitory concentration index for each combination was calculated. Results demonstrated synergistic activity between sulphamethoxazole and trimethoprim, and between sulfadoxine and pyrimethamine.
D002460:Cell Line; D002692:Chlamydia trachomatis / Q000187:drug effects*; D003470:Culture Media; D004338:Drug Combinations / Q000494:pharmacology; D006801:Humans; D011739:Pyrimethamine / Q000494:pharmacology*; D013413:Sulfadoxine / Q000494:pharmacology*; D013420:Sulfamethoxazole / Q000494:pharmacology*; D013424:Sulfanilamides / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D003470:Culture Media; D004338:Drug Combinations; D013424:Sulfanilamides; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D013413:Sulfadoxine; D014295:Trimethoprim; D013420:Sulfamethoxazole; D011739:Pyrimethamine