Effect of inherent urine output on the response of male rats to 7.5% dietary sodium saccharin.
Young male rats were preselected as high urine (57 g/kg body weight) or low urine (35 g/kg) voiders and were fed a diet containing 7.5% sodium saccharin (NaS) for 10 wk. Urine output was found to be a stable characteristic and high urine output was associated with increased water and feed consumption and increased weight gain. Rats responded in a very similar fashion to 7.5% dietary NaS regardless of their inherent urine output. NaS ingestion was associated with increases in water consumption, caecal mass and urine volume. Among rats that had ingested 7.5% dietary NaS for 10 wk there was a high incidence (12/20) of bladder epithelial hyperplasia. The results are discussed with regard to the concept that increased urine output is an important factor in NaS-induced bladder tumours.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002432:Cecum / Q000033:anatomy & histology; D004032:Diet; D004231:Diuresis / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004848:Epithelium / Q000473:pathology; D006965:Hyperplasia / Q000139:chemically induced; D007200:Indican / Q000652:urine; D008297:Male; D009929:Organ Size; D009994:Osmolar Concentration; D010179:Pancreas / Q000033:anatomy & histology; D051381:Rats; D012439:Saccharin / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D001743:Urinary Bladder / Q000473:pathology; D014556:Urine
D012439:Saccharin; D007200:Indican