[Quantitative evaluation of the cytoarchitectonic reorganization of the locus coeruleus in the brain stem under the influence of 6-hydroxydopamine].
It has been demonstrated the reorganization of structure of locus coeruleus in the animals treated intracisternally with 300 micrograms of 6-hydroxydopamine (6-OHDA) which selectively causes the lesion in catecholaminergic system using the method of quantitative estimation of the degree of uniformity and isotropy of structures. After administration of specific neurotoxin in early stages chromatolytic changes were observed in neurons which were not yet destructive but contractive for long. After injection of 6-OHDA in 36 days in the cytoarchitectonic structure were observed marked changes in uniformity and isotropy of neuron distribution within some groups in locus coeruleus versus controls.
D000818:Animals; D002946:Cisterna Magna; D006892:Hydroxydopamines / Q000633:toxicity*; D007267:Injections; D008125:Locus Coeruleus / Q000166:cytology / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D009562:Nissl Bodies / Q000187:drug effects / Q000648:ultrastructure; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D006892:Hydroxydopamines; D016627:Oxidopamine
Kolichestvennaia otsenka tsitoarkhitektonicheskoĭ reorganizatsii golubnogo piatna stvola mozga pod vliianiem 6-oksidofamina.