[Prevention of post-resuscitation impairment of energy metabolism in the myocardium using sodium gamma-hydroxybutyrate, ionol and gutimine].
Long-term impairments of energy metabolisms in myocardium were found in rats after clinical death caused by acute hemorrhage. Bioenergetics of myocardium tended to normalize within a month after resuscitation. Severity of postresuscitation period correlated with the level of deteriorations observed in energy metabolism. Preadministration of gamma-aminobutyric acid, ionol and gutimine decreased these impairments as well as the postresuscitation lethality. Considering the final results of resuscitation the efficiency of the drugs studied might be arranged in a following order: gamma-aminobutyric acid, ionol, gutimine.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D004734:Energy Metabolism / Q000187:drug effects; D006164:Guanylthiourea / Q000627:therapeutic use*; D006331:Heart Diseases / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011379:Prognosis; D051381:Rats; D012151:Resuscitation / Q000009:adverse effects*; D012978:Sodium Oxybate / Q000627:therapeutic use*; D013890:Thiourea / Q000031:analogs & derivatives*
D000975:Antioxidants; D006885:Hydroxybutyrates; D002084:Butylated Hydroxytoluene; D012978:Sodium Oxybate; D013890:Thiourea; D006164:Guanylthiourea
Preduprezhdenie postreanimatsionnykh narusheniĭ énergeticheskogo obmena miokarda gamma-oksibutiratom natriia, ionolom i gutiminom.