Alterations in hemostatic parameters during hemodialysis with dialyzers of different membrane composition and flow design. Platelet activation and factor VIII-related von Willebrand factor during hemodialysis.
The effect of dialyzer membrane and design on hemostatic parameters during hemodialysis were evaluated in a prospective controlled study. This study demonstrated that hemodialysis is associated with significant platelet activation and loss, which are influenced by both dialyzer configuration and membrane composition. In addition, use of the cuprophan membrane is associated with greater perturbations of the vascular endothelium, as reflected in changes in factor VIII-related von Willebrand factor and 6-keto-prostaglandin F1 alpha concentrations not seen with the polyacrylonitrile membrane. Of the dialyzers studied, the polyacrylonitrile membrane in a hollow-fiber configuration appears to minimize platelet loss and activation, and to minimize increases in factor VIII-related von Willebrand factor and 6-keto-prostaglandin F1 alpha.
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000180:Acrylic Resins; D000941:Antigens / Q000378:metabolism*; D001792:Blood Platelets / Q000502:physiology*; D002482:Cellulose / Q000031:analogs & derivatives; D004867:Equipment Design; D005169:Factor VIII / Q000276:immunology* / Q000378:metabolism; D006487:Hemostasis; D006801:Humans; D007688:Kidneys, Artificial; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010976:Platelet Count; D011446:Prospective Studies; D011897:Random Allocation; D006435:Renal Dialysis; D014841:von Willebrand Factor / Q000378:metabolism*
D000180:Acrylic Resins; D000941:Antigens; D008567:Membranes, Artificial; D014841:von Willebrand Factor; C010504:polyacrylonitrile; D015121:6-Ketoprostaglandin F1 alpha; D005169:Factor VIII; D002482:Cellulose; C009865:cuprammonium cellulose