title: Microbial transformation of precocene II: oxidative reactions by Streptomyces griseus.
abstract: Various species of "Streptomyces," "Aspergillus," "Rhodotorula," "Brevilegnia," "Syncephalastrum," and "Stysanus" were found to transform precocene II to three major metabolites. These major biotransformation products were isolated from a preparative-scale incubation of precocene II with Streptomyces griseus and were conclusively identified as (-)cis- and (+)trans-precocene II-3,4-dihydrodiols and (+)-3-chromenol. 18O2 incorporation studies indicated the involvement of a monooxygenase enzyme system in precocene II transformation by S. griseus. A mechanism is proposed for the formation of (+)-3-chromenol.
mesh_terms: D001578:Benzopyrans / Q000378:metabolism*; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D008401:Gas Chromatography-Mass Spectrometry; D007306:Insecticides / Q000378:metabolism*; D010084:Oxidation-Reduction; D010944:Plants; D013305:Streptomyces griseus / Q000378:metabolism*
chemical_list: D001578:Benzopyrans; D007306:Insecticides; C014163:precocene II