[Induction of hypercholesterolemia in the rabbit with semisynthetic diets. Changes in the composition of high density lipoproteins].
The effects on HDL, cholesterol and apoprotein (apo) AI and E contents in New Zealand rabbits fed on casein or soybean protein were studied. The switch from a commercial diet to the semisynthetic diets produced in only 24 hours a cholesterol enrichment of HDL in both groups, being much greater in the group receiving casein. A parallel increase on cholesterol and proteins in HDL in both dietary treatments was noted after 7 days. Apo AI content increased more in the casein group than in the one fed on soybean protein. Apo E increased 100% in the casein lot, while it did not change or tended to diminish in the soya-group. Results suggest an increase formation of HDL rich in apo E as a metabolic response to hypercholesterolemia due to feeding rabbits casein.
D000818:Animals; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000097:blood; D001057:Apolipoproteins E / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005526:Food, Formulated; D006937:Hypercholesterolemia / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood*; D011817:Rabbits
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D001057:Apolipoproteins E; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL
Inducción de hipercolesterolemia en el conejo por dietas semisintéticas. Cambios en la composición de las lipoproteínas de alta densidad.