Effects of protein, mucin, and human tears on adherence of Pseudomonas aeruginosa to hydrophilic contact lenses.
Pseudomonas aeruginosa isolated from a corneal ulcer was examined for its ability to adhere to hydrophilic contact lenses with adsorbed organic films. Generally, adherence was enhanced by mucin, lactoferrin, lysozyme, immunoglobulin A, bovine serum albumin, and a mixture of these macromolecules. The water content of the lenses also influenced bacterial adherence and protein adsorption. Adherence to lenses coated with human tear films was more complex; both enhanced and inhibited adherence were observed on lenses obtained from different individuals.
D001422:Bacterial Adhesion / Q000187:drug effects; D003263:Contact Lenses, Hydrophilic; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000378:metabolism; D007781:Lactoferrin / Q000494:pharmacology; D046911:Macromolecular Substances; D009077:Mucins / Q000494:pharmacology*; D009113:Muramidase / Q000494:pharmacology; D011506:Proteins / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000502:physiology*; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013666:Tears / Q000502:physiology*
D007071:Immunoglobulin A, Secretory; D046911:Macromolecular Substances; D009077:Mucins; D011506:Proteins; D012710:Serum Albumin, Bovine; D009113:Muramidase; D007781:Lactoferrin