Histochemical changes in the digestive tract in irradiated rats.
Wistar rats (110-125 g) were irradiated with a single dose of 500 R. Histochemical studies were done concerning the glycoproteins (GP) of sublingual glands, gastric, small intestine and colon mucosa, and some intestinal enzymes: acid and alkaline phosphatase (ACP, ALP) leucineaminopeptidase (LAP), Mg-dependent ATP-ase, NADH-diaphorase, lactic dehydrogenase (LDH). After irradiation all these reactions were diminished, with a maximal effect between 3-5 days. This impairment is in accord with the maximal lethality in this interval after such a degree of irradiation that produced the gastrointestinal syndrome. Cocarboxylase, a radioprotector, improved these changes regarding the structures of the small intestine and also the GP of sublingual glands, stomach, small intestine and colon, demonstrating there its efficiency.
D000818:Animals; D003106:Colon / Q000528:radiation effects; D004064:Digestive System / Q000032:analysis / Q000201:enzymology / Q000528:radiation effects*; D005753:Gastric Mucosa / Q000528:radiation effects; D006023:Glycoproteins / Q000032:analysis*; D006651:Histocytochemistry; D006867:Hydrolases / Q000032:analysis*; D007421:Intestine, Small / Q000528:radiation effects; D008297:Male; D010088:Oxidoreductases / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013361:Sublingual Gland / Q000528:radiation effects
D006023:Glycoproteins; D010088:Oxidoreductases; D006867:Hydrolases