Hematological effects of lithium potentiation of carbamazepine in patients with affective illness.
Hematological indices were measured in 8 patients with bipolar disorder during carbamazepine and carbamazepine-lithium combination treatment. Carbamazepine treatment was associated with limited reductions in white blood cell indices. Combined lithium-carbamazepine treatment reversed the reductions in total white cell and neutrophil counts. The clinical and theoretical implications of these findings are discussed.
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy*; D001772:Blood Cell Count; D002220:Carbamazepine / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006452:Hemoglobinometry; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged
D016651:Lithium Carbonate; D002220:Carbamazepine; D008094:Lithium