Antitoxoplasmosis properties of sinefungin in mice.
Sinefungin, an antifungal and antiviral antibiotic, which also has interesting antiparasitic properties, was examined for antitoxoplasma activity. Mice infected with a lethal dose of Toxoplasma gondii trophozoites, when injected daily for 6 days with the antibiotic, starting 2 days after infection, showed significantly increased survival times especially with the highest dose tested (2.5 mg/kg). No overt clinical signs of toxicity due to Sinefungin were observed.
D000241:Adenosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D003049:Coccidiostats / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D014124:Toxoplasmosis, Animal / Q000188:drug therapy*
D003049:Coccidiostats; D000241:Adenosine; C006235:sinefungin