Fetal death associated with a t(1;14) in three generations.
Fetal death is a common phenomenon; parental chromosome study may uncover the cause of the problem and contribute to the management of the couple involved. Discovery of a translocation provides a firm basis for genetic counseling, detection of carriers, and prenatal diagnosis. We have studied a young couple with a history of 4 consecutive spontaneous abortions before cytogenetic study demonstrated the father to carry a t(1;14). The translocation was found in 2 other adults, a liveborn child, and a fetus, in a total of 3 generations.
D000026:Abortion, Habitual / Q000235:genetics; D000328:Adult; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D005260:Female; D005313:Fetal Death / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D014178:Translocation, Genetic