Subpopulations of T-lymphocytes in IgA glomerulonephritis.
Peripheral subpopulations of T-lymphocytes were studied morphologically, cytochemically and with monoclonal antibodies (Leu 1, Leu 2a, Leu 3a) in 27 IgA glomerulonephritis cases and in 15 healthy controls. The number of helper T-lymphocytes was found significantly increased particularly in the active phase of IgA glomerulonephritis, while that of suppressor lymphocytes decreased. Thus helper/suppressor ratio increased significantly. In the inactive phase this ratio was also seen to increase but not in a significant manner. Comparing different methods used it is concluded that all of them proved to be suitable for the demonstration of altered subpopulation ratios.
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D005260:Female; D005922:Glomerulonephritis, IGA / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology* / Q000473:pathology
D000911:Antibodies, Monoclonal