T cell-derived blast crisis in chronic myelocytic leukemia.
We describe herein the occurrence of a T cell-derived blast crisis of chronic myelocytic leukemia which presented as a typical T cell leukemia on clinical (thymic mass and high white blood cells) and immunological grounds (T6+ T4+ T8+), with rearranged T cell receptor genes and germ line immunoglobulin genes. A Philadelphia chromosome was detected in all blast cell mitoses. The significance of T cell involvement during the chronic and acute phases of chronic myelocytic leukemia is discussed.
D000328:Adult; D000943:Antigens, Differentiation / Q000032:analysis; D001752:Blast Crisis / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D005260:Female; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007951:Leukemia, Myeloid / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D010677:Philadelphia Chromosome; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes / Q000473:pathology*
D000943:Antigens, Differentiation; D007143:Immunoglobulin Heavy Chains; D011948:Receptors, Antigen, T-Cell