Chromosomal translocations and gene rearrangements in non-Hodgkin lymphomas.
Unlike other types of malignancy, non-Hodgkin lymphomas have a specific reciprocal chromosomal translocation as a genomic hallmark in most patients. Among the more prevalent B-cell lymphomas, 65% of patients show a 14q + chromosome with rearrangement of the heavy-chain immunoglobulin genes at band 14q32.3, whereas the less common T-cell lymphomas typically have a selective rearrangement of the alpha T-cell receptor genes involving band 14q11.2. The presence of additional recurrent chromosomal defects in several subgroups of lymphomas is associated with tumor phenotype, evolution, and response to therapy.
D002883:Chromosomes, Human, Pair 14; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D009857:Oncogenes; D014178:Translocation, Genetic
D007143:Immunoglobulin Heavy Chains