title: Duodenogastric reflux in Chagas' disease.
abstract: Increased duodenogastric reflux has been recognized as a cause of gastric mucosa damage. The frequent finding of bile-stained gastric juice and a suggested higher frequency of lesions of the gastric mucosa in patients with Chagas' disease, which is characterized by a marked reduction of myenteric neurons, suggest that impairment of intrinsic innervation of the gut might be associated with increased duodenogastric reflux. Duodenogastric bile reflux was quantified after intravenous injection of 99mtechnetium-HIDA, in 18 patients with chronic Chagas' disease, 12 controls, and 7 patients with Billroth II gastrectomy. All but one of the chagasic patients were submitted to upper digestive tract endoscopy. High reflux values (greater than or equal to 10%) were detected both in chagasic patients and in the controls, but the values for both groups were significantly lower (P less than 0.01) than those obtained for Billroth II patients (median: 55.79%; range: 12.58-87.22%). Reflux values tended to be higher in the Chagas' disease group (median: 8.20%; range: 0.0-29.40%) than in the control group (median: 3.20%; range: 0.0-30.64%), with no statistical difference between the two groups (P greater than 0.10). Chronic gastritis was detected by endoscopy in 12 chagasic patients, benign gastric ulcer in 2 patients, and a pool of bile in the stomach in 11 patients. However, neither the occurrence of gastric lesions nor the finding of bile-stained gastric juice was associated with high reflux values after [99mTc]HIDA injection. This study suggests that lesions of the intramural nervous system of the gut in Chagas' disease do not appear to be associated with abnormally increased duodenogastric reflux.
mesh_terms: D000328:Adult; D001646:Bile / Q000032:analysis; D014355:Chagas Disease / Q000150:complications*; D004383:Duodenogastric Reflux / Q000150:complications*; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects; D005750:Gastric Juice / Q000032:analysis; D005773:Gastroscopy; D006801:Humans; D007098:Imino Acids; D008297:Male; D008875:Middle Aged; D013272:Stomach Diseases / Q000209:etiology; D013667:Technetium
chemical_list: D007098:Imino Acids; D013667:Technetium; C049470:lidofenin