New heritable fragile site on chromosome 8 induced by distamycin A.
A possible new heritable fragile site at band 8q24.1, which is known to be a breakpoint in various cancers and contains the c-myc locus, was found in the lymphocytes from a woman with mastopathy. This fragile site was induced by distamycin A treatment, and expressed as gaps and breaks in 18% of the metaphases examined. The lymphocytes from one of her two sons examined also revealed gaps or breaks at the same site of chromosome 8 in 34% of the metaphases. This fragile 8q24.1 band is considered to be a new heritable fragile site induced by distamycin A.
D000328:Adult; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002898:Chromosomes, Human, Pair 8; D004214:Distamycins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D011519:Proto-Oncogenes; D011758:Pyrroles / Q000494:pharmacology*
D004214:Distamycins; D011758:Pyrroles; C030000:stallimycin