Protective effect of the new calcium antagonist anipamil against isoprenaline-induced cardionecrosis in rats.
The new calcium antagonist anipamil (1,7-bis-(3-methoxyphenyl)-3-methylaza-7-cyano-nonadecane) exhibited a pronounced protective effect against isoprenaline-induced myocardial necrosis in rats. Anipamil was administered in single doses of 10 or 20 mg/kg daily for 4 days. 30 mg/kg isoprenaline was given by subcutaneous injection on the 3rd and 4th days of the study. The protective effect of anipamil was assessed by histological investigations, and its effect on the activity of the enzymes succinate dehydrogenase, NADH-NBT reductase, acid phosphatase and glucose-6-phosphate dehydrogenase in experimentally-induced myocardial damage was assessed quantitatively by microphotometry. The protective effect of anipamil against isoprenaline-induced myocardial necrosis was definitely dose-dependent: 10 mg/kg anipamil exhibited a partial protective effect, whilst 20 mg/kg anipamil protected the heart completely.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D009202:Cardiomyopathies / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D007545:Isoproterenol / Q000633:toxicity*; D008297:Male; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D009336:Necrosis; D011437:Propylamines / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013385:Succinate Dehydrogenase / Q000378:metabolism
D002121:Calcium Channel Blockers; D011437:Propylamines; C045313:anipamil; D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; C021848:NADPH-tetrazolium reductase; D009251:NADPH-Ferrihemoprotein Reductase; D000135:Acid Phosphatase; D007545:Isoproterenol