title: Submitochondrial localization of rat liver beta-alanine-oxoglutarate aminotransferase.
abstract: beta-Alanine-oxoglutarate aminotransferase from rat liver was mainly distributed in the mitochondrial fraction, while beta-ureidopropionase, the last one of uracil-metabolizing enzymes to beta-alanine, was predominantly distributed in the cytosolic fraction. When rat liver mitochondria were separated into submitochondrial fractions, beta-alanine-oxoglutarate aminotransferase was localized in the mitochondrial matrix. beta-Alanine was transported into mitochondria with time and the influx of beta-alanine into the matrix was 0.47 nmol/mg of mitochondrial protein at 2 min after incubation.
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000032:analysis*; D000581:Amidohydrolases / Q000032:analysis; D000818:Animals; D008099:Liver / Q000201:enzymology / Q000648:ultrastructure*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013367:Submitochondrial Particles / Q000201:enzymology*; D015091:beta-Alanine / Q000378:metabolism
chemical_list: D015091:beta-Alanine; D000612:4-Aminobutyrate Transaminase; D000581:Amidohydrolases; C021590:beta-ureidopropionase