title: Production of interferon gamma by lymphocytes exposed to antibody-coated spermatozoa: a mechanism for sperm antibody production in females.
abstract: The ability of sperm to induce lymphocytes from female donors to produce interferon gamma (IFN) was measured. Of nine samples where immunoglobulin was bound to ejaculated motile sperm, five (55.6%) induced IFN production. In contrast, only 1 of 35 (2.9%) sperm samples lacking bound immunoglobulins induced IFN (P less than 0.005). Incubation of donor sperm with sperm antibody containing sera from nine male patients led, in seven cases (77.8%), to acquisition by sperm of the ability to induce IFN. Lymphocytes from eight of eight females tested all responded to sperm with bound antibodies. IFN induction of Ia antigen expression on macrophage may be required for recognition of processed sperm antigens by the female's T helper cells.
mesh_terms: D000906:Antibodies / Q000276:immunology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007371:Interferon-gamma / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008297:Male; D013094:Spermatozoa / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000906:Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007371:Interferon-gamma