Measurements of the effects of percutaneous nitroglycerin on left ventricular performance in patients with coronary artery disease with a cardiac probe.
Left ventricular function was measured after percutaneous nitroglycerin in ten patients with coronary artery disease under double blind random control. The elevation of LVEF after percutaneous nitroglycerin paste (containing 10 mg nitroglycerin) was 8.3% +/- 1.3% (P less than 0.001) at 30 min, 8.5% +/- 1.8% (P less than 0.001) at 60 min, 10.1% +/- 1.8% (P less than 0.001) at 90 min and 8.7% +/- 2.2% (P less than 0.01) at 120 min respectively, but the change of LVEF after nitroglycerin ointment (containing 5 mg nitroglycerin) was not significant. The elevation of ER and RCO after nitroglycerin paste were 0.448 +/- 0.088 (EDV/s) (P less than 0.001), 6.73 +/- 1.47 (EDV/s) (P less than 0.01) at 30 min, 0.376 +/- 0.078 (P less than 0.001), 6.64 +/- 1.36 (P less than 0.001) at 60 min, 0.456 +/- 0.089 (P less than 0.001), 8.02 +/- 2.11 (P less than 0.001) at 90 min and 0.358 +/- 0.076 (P less than 0.01), 6.18 +/- 2.05 (P less than 0.01) respectively. It was demonstrated that percutaneous nitroglycerin paste (10 mg nitroglycerin) can improve the left ventricular function of patients with coronary artery disease.
D000287:Administration, Topical; D000328:Adult; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D004912:Erythrocytes; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage / Q000627:therapeutic use*; D009824:Ointments; D011897:Random Allocation; D013667:Technetium
D009824:Ointments; D013667:Technetium; D005996:Nitroglycerin