title: [Randomized double-blind placebo-controlled study of drugs with anti-ulcer action and their use in associated pathology].
abstract: The effect of lithium preparations (lithium carbonate, lithium oxybutyrate), calcium channel blocking agents (verapamil, nifedipine), beta 2-adrenoagonist (salbutamol), cromolyn sodium and cimetidine on clinical efficacy and frequency of ulcer cicatrization was assessed in 201 patients (33 women, 168 men) with endoscopically verified stomach ulcer (52 patients) and duodenal ulcer (166 patients) during treatment for 4 weeks as compared to placebo and standard antiulcerative therapy (cholinolytics, antacids and reparents). All the tested drugs (excluding cromolyn sodium) significantly increased as compared to placebo the frequency of ulcer cicatrization (p less than 0.001 in the use of lithium preparations and cimetidine; p less than 0.01 in the use of salbutamol and verapamil; p less than 0.05 in the use of nifedipine). The effect of lithium preparations and cimetidine exceeded that of standard antiulcerative multimodality therapy.
mesh_terms: D000328:Adult; D000420:Albuterol / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004205:Cromolyn Sodium / Q000627:therapeutic use; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006885:Hydroxybutyrates / Q000627:therapeutic use; D008094:Lithium / Q000627:therapeutic use; D016651:Lithium Carbonate; D008297:Male; D009942:Organometallic Compounds / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000150:complications / Q000188:drug therapy*; D011897:Random Allocation
chemical_list: D000897:Anti-Ulcer Agents; D002121:Calcium Channel Blockers; D006885:Hydroxybutyrates; D009942:Organometallic Compounds; D016651:Lithium Carbonate; C022826:lithium hydroxybutyrate; D008094:Lithium; D004205:Cromolyn Sodium; D000420:Albuterol
vernacular_title: Randomizirovannoe dvoĭnoe slepoe platsebo-kontroliruemoe ispytanie lekarstvennykh preparatov s protivoiazvennoĭ aktivnost'iu i ikh promenenie pri sochetannoĭ patologii.