title: High-titer, high-thermal-amplitude cold autoagglutinin not associated with hemolytic anemia.
abstract: An example of an unusual cold autoagglutinin is reported. The antibody was monoclonal IgMKappa able to fix complement, and, in the presence of albumin, had both a high titer (greater than 4,096 at 4 degrees C) and a wide thermal range (4-37 degrees C). The patient was closely followed over a 3-year period with no evidence of hemolysis ever documented, despite a persistently positive direct antiglobulin test and the presence of the cold autoagglutinin. In contrast to previous reports regarding cold-agglutinin disease, this case demonstrates that in vivo hemolysis is not always associated with cold autoagglutinins that in vitro show a high thermal range in the presence of albumin.
mesh_terms: D000373:Agglutinins / Q000032:analysis*; D000743:Anemia, Hemolytic / Q000097:blood*; D003080:Cold Temperature; D003298:Coombs Test; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D008297:Male; D008875:Middle Aged
chemical_list: D000373:Agglutinins; D007145:Immunoglobulin kappa-Chains