Pilot study on the regional treatment of colorectal liver metastases by intermittent arterial ischaemia with degradable starch microspheres and arterial and portal infusion with mitomycin C plus 5-fluorouracil--a clinical trial led by the Gastrointestinal Tumour Cooperative Group E.O.R.T.C.
After interruption of the hepatic artery, the decrease of the arterial flow in the liver is temporary and the tumor periphery remains vascularized by the portal system. A rational approach of therapy for liver metastases seems to be a combined therapy including intermittent ischaemia by distal embolization through the hepatic artery with degradable starch microspheres and locoregional chemotherapy. A pilot study on the regional treatment of colorectal liver metastases by intermittent arterial ischaemia and intra-arterial and portal infusion of mitomycin C and 5-FU has recently been activated by the gastrointestinal tumor group of the European Organization on Research on Treatment of Cancer (EORTC) with the aim to evaluate the feasibility and the therapeutic value of such a clinical trial. Although it is too early to evaluate the results of this therapy, the first data will be commented.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms; D004621:Embolization, Therapeutic / Q000379:methods; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D008113:Liver Neoplasms / Q000098:blood supply / Q000556:secondary / Q000628:therapy*; D008863:Microspheres; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D010865:Pilot Projects; D011169:Portal Vein; D012004:Rectal Neoplasms; D013213:Starch / Q000008:administration & dosage*
D008937:Mitomycins; D016685:Mitomycin; D013213:Starch; D005472:Fluorouracil