[Cytometric study of the effects of destruxin E on leukemic cells in mice].
The activity of destruxin E, a cryptogamic toxin isolated from the hyphomycete Metarhizium anisopliae, was studied on mouse leukemia cells (L 1210 and P 388) in culture. Besides a cytotoxic effect, a cytostatic effect (increase of diploïd cells proportion) was observed with all doses for P 388 (from 10 micrograms/ml to 0.001 microgram/ml) and to a concentration of 0.1 microgram/ml for L 1210. At the lower doses, the effect on cellular DNA content appears distinctly.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004273:DNA, Neoplasm / Q000032:analysis; D005434:Flow Cytometry; D007939:Leukemia L1210 / Q000473:pathology*; D007941:Leukemia P388 / Q000473:pathology*; D007942:Leukemia, Experimental / Q000473:pathology*; D051379:Mice; D008811:Mice, Inbred DBA; D009183:Mycotoxins / Q000494:pharmacology*
D004273:DNA, Neoplasm; D009183:Mycotoxins
Etude cytométrique des effets de la destruxine E sur des cellules leucémiques de souris.