title: Mutagenicity studies on terbacil, an uracil-analogue pesticide.
abstract: The possible mutagenic effect of the uracil analogue pesticide Terbacil was examined on Drosophila melanogaster and in mammalian cell culture. Terbacil did not prove to be mutagenic in the sex-linked recessive lethal mutation test, and it did not cause an increase in sister chromatid exchange in CHO cells. It cannot be considered a chromosome-mutagenic compound. Considering the procaryote studies known from the literature, it is assumed that Terbacil does not represent a genotoxic hazard for the persons involved either in its production or its use.
mesh_terms: D000818:Animals; D002460:Cell Line; D004331:Drosophila melanogaster / Q000235:genetics; D006540:Herbicides / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens; D012854:Sister Chromatid Exchange / Q000187:drug effects; D014498:Uracil / Q000031:analogs & derivatives* / Q000633:toxicity
chemical_list: D006540:Herbicides; D009153:Mutagens; D014498:Uracil; C011362:terbacil