[The effect of alpha-liponic acid, vitamin B or gangliosides on the regeneration of traumatically damaged peripheral nerves in the rat. A comparative, morphometric study].
The sciatic nerve of male rats was crushed in accordance with a standardized method. To investigate the positive influence of different substances on nerve regeneration, the rats received daily injections of alpha-liponic acid, vitamin B or gangliosides. After 11 days the sciatic nerves were removed and the area distal to the crush site was analyzed histomorphometrically. Compared with the control group, there was only a slight increase in the number of regenerating fibres and their diameters following treatment with alpha-liponic acid or vitamin B. However, in the ganglioside-treated rats the differences, indicative of accelerated regeneration, were statistically significant.
D000818:Animals; D005732:Gangliosides / Q000494:pharmacology*; D008297:Male; D009409:Nerve Crush; D009416:Nerve Regeneration / Q000187:drug effects*; D010525:Peripheral Nerves / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D008063:Thioctic Acid / Q000494:pharmacology*; D014803:Vitamin B Complex / Q000494:pharmacology*
D005732:Gangliosides; D014803:Vitamin B Complex; D008063:Thioctic Acid
Einfluss von alpha-Liponsäure, Vitamin B oder Gangliosiden auf die Regeneration traumatisch geschädigter, peripherer Nerven der Ratte. Eine vergleichende, morphometrische Studie.