Combined features of myasthenia gravis and Eaton-Lambert syndrome: anti-ganglioside antibodies in serum.
We studied 2 patients with Eaton-Lambert syndrome showing some features of myasthenia gravis. Among 9 different glycolipid antigens examined, serum titers of IgG antibodies to GT1b, GD1a, and sialylparagloboside were increased. Those antibodies may be involved in the pathogenesis of the presynaptic neuromuscular block that was presumed to be present in these patients.
D001323:Autoantibodies / Q000097:blood*; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007142:Immunoglobulin gamma-Chains; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000276:immunology*; D009468:Neuromuscular Diseases / Q000276:immunology*
D001323:Autoantibodies; D005732:Gangliosides; D007142:Immunoglobulin gamma-Chains