Successful GnRH treatment in a patient with Kallmann's syndrome, who previously failed HMG/HCG treatment.
A successful GnRH treatment for hypogonadotropic hypogonadism is described. A 40 year old infertile patient due to Kallmann's syndrome, associated with obesity and NIDDM, was treated with HCG (5,000 IU/week) for 8 years. In an attempt to induce spermatogenesis HMG (75 IU/daily) was added for 2 years. During the combined gonadotropin treatment semen analysis indicated an improvement from azoospermia to 2 x 10(6) sperm/ml. Since semen quality remained poor and obviously no pregnancy was achieved, the last regime was replaced by a pulsatile GnRH treatment (5 mcg/90 minutes). Following 6 months sperm count increased up to 15 x 10(6) associated with normal motility and morphology. Patient's wife conceived after the second intrauterine insemination and delivered a full term healthy baby.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D048909:Diabetes Complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007006:Hypogonadism / Q000150:complications / Q000188:drug therapy*; D007248:Infertility, Male / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008596:Menotropins / Q000627:therapeutic use; D009765:Obesity; D010906:Pituitary Hormone-Releasing Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D013076:Sperm Count; D013577:Syndrome; D013739:Testosterone / Q000097:blood
D006063:Chorionic Gonadotropin; D010906:Pituitary Hormone-Releasing Hormones; D013739:Testosterone; D008596:Menotropins