title: [Changes in isoagglutinin titers after high-voltage therapy with the large-field technic in Hodgkin's disease patients].
abstract: In 48 patients with Hodgkin's disease, the naturally occurring isoagglutinins anti A1, anti A2 and anti B were investigated and their titer determined before commencement of radiotherapy as well as after the end of radiotherapy, and in a proportion of the patients six and twelve months after the end of radiotherapy. Radiotherapy resulted in a highly significant fall in the isoagglutinin titer amounting on average to one titer level compared to the initial value before radiotherapy. After the end of radiotherapy, there was no further fall of the isoagglutinin titers, but a marked reduction of the isoagglutinin titers was still shown six and twelve months later. A long lasting reduction of serum immunoglobulins after radiotherapy in patients with Hodgkin's disease is known from earlier investigations; this applies in particular to IgM. Since the isoagglutinins mainly belong to the IgM fraction, our finding of persistent reduction of isoagglutinin titers after radiotherapy correlates with the known long-lasting reduction of serum IgM concentration.
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology; D000373:Agglutinins / Q000032:analysis* / Q000528:radiation effects; D004912:Erythrocytes / Q000276:immunology; D006689:Hodgkin Disease / Q000276:immunology* / Q000532:radiotherapy; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis / Q000528:radiation effects; D007518:Isoantibodies / Q000032:analysis* / Q000528:radiation effects; D011882:Radiotherapy, High-Energy / Q000379:methods*; D013997:Time Factors
chemical_list: D000017:ABO Blood-Group System; D000373:Agglutinins; D007075:Immunoglobulin M; D007518:Isoantibodies
vernacular_title: Anderungen der Isoagglutinintiter nach Hochvolttherapie mit Grossfeldtechnik bei Patienten mit Morbus Hodgkin.