Arachidonic acid metabolism.
Arachidonic acid metabolites can act as tumor promoters and can affect growth and metastases of tumors in three ways: (a) Prostacyclin inhibits and thromboxane facilitates platelet-tumor cell interactions and, thereby, tumor cell invasiveness; (b) the cytoprotective action of prostaglandins contributes to epithelial cell integrity and influences tissue response to tumor-promoting agents; and (c) lipoxygenase products may act as tumor promoters.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*
D001095:Arachidonic Acids; D011453:Prostaglandins; D016718:Arachidonic Acid