[Tracheal instillation of arachidonic acid as an asthma model in guinea pigs--preliminary results of the effect of inhibitors of arachidonic acid metabolism].
An in-vivo asthma model in guinea pig by tracheal instillation of sodium-arachidonate in artificially ventilated animals was introduced. The introduced model seems to be sufficient for testing inhibitors of arachidonate metabolism for antiasthmatic activity.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors* / Q000378:metabolism; D001241:Aspirin / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy*; D016861:Cyclooxygenase Inhibitors; D004195:Disease Models, Animal; D006168:Guinea Pigs; D016859:Lipoxygenase Inhibitors
D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D016718:Arachidonic Acid; D001241:Aspirin
Tracheale Instillation von Arachidonsäure als Asthmamodell am Meerschweinchen--erste Ergebnisse zum Einfluss von Hemmstoffen des Arachidonsäuremetabolismus.