Bone marrow transplantation from an unrelated donor for Fanconi's anaemia: two unusual complications.
An eight-year-old boy with Fanconi's anaemia received a bone marrow transplantation from an unrelated donor. Sustained engraftment was achieved, but he developed major complications including acute grade III graft-versus-host disease, autoimmune haemolytic anaemia with positive Coombs' test and free antibodies against Rhesus group, and a virus-associated haemophagocytic syndrome; this latter complication was successfully treated with acyclovir. Sixteen months after transplantation he has full haematopoietic reconstitution, but with persisting mild autoimmune haemolysis.
D000741:Anemia, Aplastic / Q000628:therapy*; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications; D016026:Bone Marrow Transplantation; D005199:Fanconi Anemia / Q000628:therapy*; D006086:Graft vs Host Disease / Q000150:complications; D008297:Male; D010587:Phagocytosis; D012204:Rh-Hr Blood-Group System; D014777:Virus Diseases / Q000150:complications
D012204:Rh-Hr Blood-Group System