Epithelial HLA-DR expression and lymphocyte subsets in gastric mucosa in type B chronic gastritis.
Lymphocyte subpopulations (B, T4, T8), monocytes/macrophages (LeuM5, KiM5) and HLA-DR antigen expression were studied immunohistochemically in frozen sections from 32 antral and 37 fundal biopsies of type-B chronic gastritis. Aberrant HLA-DR antigen expression in epithelial cells of gastric mucosa was found in all cases closely related to mononuclear infiltrates. Epithelial HLA-DR expression and mononuclear infiltrates were practically absent in foci of intestinal metaplasia. These findings suggest that an immunopathologic mechanism probably plays a role in initiation or perpetuation of type-B chronic gastritis.
D002908:Chronic Disease; D005753:Gastric Mucosa / Q000276:immunology* / Q000473:pathology; D005756:Gastritis / Q000276:immunology* / Q000473:pathology; D006681:HLA-D Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000145:classification / Q000276:immunology / Q000473:pathology
D006681:HLA-D Antigens; D006684:HLA-DR Antigens