[Induction of sarcomas by a nontumorigenic type of foreign body and glutaraldehyde].
Nontumorigenic form of cellophane has been implanted subcutaneously into rats, and simultaneously an injection of 0.5 ml 2.5% buffered glutaraldehyde has been given at the site of implantation. Glutaraldehyde injections at the same site were repeated at 4 consecutive days. This treatment induced sarcomas in 21 out of 33 rats (63.6%). Mean latency period of tumor development was 15.7 months. Tumours were diagnosed as polymorphocellular, undifferentiated sarcomas, fibrosarcomas.
D000447:Aldehydes / Q000633:toxicity*; D000818:Animals; D003094:Collagen; D005547:Foreign Bodies / Q000150:complications*; D005549:Foreign-Body Reaction / Q000473:pathology; D005976:Glutaral / Q000633:toxicity*; D008297:Male; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D013499:Surface Properties
D000447:Aldehydes; D003094:Collagen; D005976:Glutaral
Induktsiia sarkom neblastomogennoĭ formoĭ inorodnogo tela i glutaral'degidom.