[Effect of diets of various levels of linoleic acid on prostanoid biosynthesis and arterial blood pressure in rats].
The authors studied the influence of diets with 0 cal % (diet 1), 9 cal % (diet 2, control) and 16 cal %, according to linoleic acid, on the arterial blood pressure (ABP) and exogenous biosynthesis of prostacyclin (PGI2), PGF2 and PGE2 from 14C-arachidonic acid in isolated aortal rings and thromboxane (TxA2), PGF2 alpha, PGE2 in the suspension of washed platelets. It was established that diet 1 used during 4.5 months led to a rise in the ABP and decreased biosynthesis of all the prostanoids studied, as compared to the control. Linoleic acid excess (diet 3) induced a more pronounced elevation of the ABP and reduction of PGI2 synthesis in the aorta and TxA2 in the washed platelets, as compared to the control.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004041:Dietary Fats / Q000008:administration & dosage*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage*; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011921:Rats, Inbred WKY
D001095:Arachidonic Acids; D004041:Dietary Fats; D008041:Linoleic Acids; D011453:Prostaglandins; D016718:Arachidonic Acid; D019787:Linoleic Acid
Vliianie diet s razlichnym soderzhaniem linolevoĭ kisloty na biosintez prostanoidov i arterial'noe davlenie u krys]