Melanogenesis in Cryptococcus neoformans.
Melanogenesis in Cryptococcus neoformans begins with the oxidation of dihydroxyphenylalanine by the enzyme phenol oxidase. The succeeding steps are very rapid. Two intermediates, dopachrome and 5,6-dihydroxyindole, have been isolated and characterized by high performance liquid chromatography. A pathway of melanin formation in C. neoformans is proposed, based on the presence of these intermediates.
D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D003454:Cryptococcus / Q000378:metabolism*; D003455:Cryptococcus neoformans / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D008543:Melanins / Q000096:biosynthesis*
D008543:Melanins; D004295:Dihydroxyphenylalanine