Eicosanoids and myocardial ischaemia.
The available data clearly suggest large alterations in myocardial eicosanoid generation during myocardial ischaemia and demonstrate important actions of eicosanoids on myocardial function during ischaemic conditions. These actions include direct effects on the injured myocardium as well as influences on other target cells, such as platelets and leukocytes. Selective modifications of eicosanoid generation, for example by providing exogenous PGI2 or by inhibiting oxygen toxicity are most challenging approaches for the design of new and potentially valuable cardioprotective agents. Antagonism of thromboxane formation and/or action might be of some value in ischaemia but appears to be less important for reperfusion injury. Leukotrienes and other noncyclic fatty acid peroxidation products are another group of potentially deleterious agents and there is a definite need for more selective inhibitors of leukotriene formation and/or action to establish their role in ischaemia.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D004734:Energy Metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism* / Q000494:pharmacology; D007962:Leukocytes / Q000378:metabolism; D008084:Lipoxygenase / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism
D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D016718:Arachidonic Acid; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D010100:Oxygen