[The significance of a positive reaction to anti-serotonin (5-HT) in certain hypothalamic neurons of the rat during the perinatal period].
In this study, two regions containing 5-HT immunopositive neurons were observed in the hypothalamus of fetal (18th fetal day) and neonatal rats (9th postnatal day) after pretreatment with the monoamine oxidase inhibitor, pargyline, and the amino acid precursor of the 5-HT synthesis, l-tryptophan. They were localized in the anterolateral hypothalamus and the dorso-medial hypothalamic nucleus. Immunostaining was completely blocked by the preliminary injection of fluoxetine, a specific uptake inhibitor of the serotoninergic neurons. Thus, the 5-HT immunostaining of hypothalamic neurons reported in this study is accounted for by the specific uptake of the 5-HT from the environment rather than by its synthesis from l-tryptophan.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D005333:Fetus / Q000378:metabolism*; D005473:Fluoxetine / Q000494:pharmacology; D007031:Hypothalamus / Q000032:analysis* / Q000187:drug effects / Q000196:embryology; D007150:Immunohistochemistry; D008996:Monoamine Oxidase Inhibitors; D009474:Neurons / Q000032:analysis*; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis*; D014364:Tryptophan / Q000494:pharmacology
D008996:Monoamine Oxidase Inhibitors; D005473:Fluoxetine; D012701:Serotonin; D014364:Tryptophan; D010293:Pargyline
Sur la signification de la réation positive à l'anti-sérotonine (5-HT) de certains neurones hypothalamiques du rat dans la période périnatale.