[Effect of autoimmune destruction and rejection on the function of transplanted islands of Langerhans in spontaneous diabetes in the BB rat].
In animals and human identical twin transplants the autoimmunity of naturally occurring diabetes may destroy transplanted islets, even if rejection is avoided. We studied the influence of transplant site (liver vs. kidney capsule) and pretransplant treatment (culture) on autoimmune damage and rejection of transplanted islets of Langerhans in BB-rats which spontaneously developed diabetes. Freshly isolated and in the liver transplanted islets were destroyed rapidly (on the base of autoimmune destruction, rejection or both). In contrary, the renal subcapsule shows to be immunologically privileged with long survival of transplants. Culture pretreatment of MHC-incompatible Lewis islets resulted in long survival of transplants, which was not true in case of MHC-compatible WF islets: immunological disparity of donor and recipient tissue might be most successful in preventing autoimmune damage and rejection.
D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000276:immunology*; D006084:Graft Rejection; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000276:immunology; D016381:Islets of Langerhans Transplantation; D008285:Major Histocompatibility Complex; D051381:Rats; D011913:Rats, Inbred BB; D011919:Rats, Inbred Strains
D001323:Autoantibodies; D001786:Blood Glucose; D007328:Insulin
Einfluss von Autoimmunzerstörung und Abstossung auf die Funktion transplantierter Langerhansscher Inseln im spontanen Diabetes der BB-Ratte.