Effects of dietary xenobiotics on the metabolism of copper, alpha-tocopherol and cholesterol in rats.
The effects of dietary addition of some xenobiotics on tissue levels of copper and alpha-tocopherol in rats were studied with special reference to serum cholesterol. The chemicals added here were 0.05% polychlorinated biphenyls (PCB), 0.3% caffeine, 0.05% 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 0.3% flavone, 0.3% chloretone, 0.3% 2-tert-butyl-4-methoxyphenol (BHA), 0.15% sodium phenobarbital, 0.15% phenytoin, 0.2% sodium pentobarbital, and 0.15% phenylbutazone. Of these chemicals, dietary PCB, caffeine, DDT, flavone, chloretone, BHA and phenytoin raised the level of copper in liver, kidney, or serum. Serum alpha-tocopherol and cholesterol also increased with the additive or synergistic effects on these metabolisms. Moreover, these combined addition of dietary 0.02% PCB with 0.2% BHA seemed to cause additive or synergistic effects on these metabolism. Moreover, these chemicals raised serum ceruloplasmin activity. In general, serum copper, ceruloplasmin activity and alpha-tocopherol were correlated with serum cholesterol in these dietary manipulations.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D002570:Ceruloplasmin / Q000378:metabolism; D002724:Chlorobutanol / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood*; D003300:Copper / Q000097:blood / Q000378:metabolism*; D003634:DDT / Q000494:pharmacology; D004032:Diet; D047309:Flavones; D005419:Flavonoids / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010672:Phenytoin / Q000494:pharmacology; D011078:Polychlorinated Biphenyls / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000097:blood / Q000378:metabolism*
D047309:Flavones; D005419:Flavonoids; D004364:Pharmaceutical Preparations; D014810:Vitamin E; D002083:Butylated Hydroxyanisole; D002110:Caffeine; D010672:Phenytoin; D003300:Copper; D002784:Cholesterol; D003634:DDT; D011078:Polychlorinated Biphenyls; D002570:Ceruloplasmin; D002724:Chlorobutanol; C043562:flavone