[Pyrimidine nucleotide triphosphate control of the phosphorylation of cytidine in the rat heart].
The phosphorylation of 5 microM cytidine by the isolated perfused rat heart was increased by 50 and 120% respectively, when the myocardial UTP content was increased by 30%, 1 hr. after the treatment of animals with isoprenaline (5 mg/kg; s.c.) and by 50%, 6 hrs. after the treatment of animals with galactosamine (430 mg/kg; i.p.). On the other hand, this rate of synthesis of cytidylic nucleotides from cytidine was not decreased when the intracellular UTP and cytidylic nucleotide levels were increased through 130 and 90% respectively (12 hrs. after isoprenaline treatment).
D000818:Animals; D003562:Cytidine / Q000378:metabolism; D003597:Cytosine Nucleotides / Q000096:biosynthesis*; D005260:Female; D005688:Galactosamine / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains; D014500:Uracil Nucleotides / Q000378:metabolism*; D014544:Uridine Triphosphate / Q000378:metabolism*
D003597:Cytosine Nucleotides; D014500:Uracil Nucleotides; D003562:Cytidine; D005688:Galactosamine; D007545:Isoproterenol; D014544:Uridine Triphosphate
Contrôle par les nucléotides pyrimidiques triphosphates de la phosphorylation de la cytidine dans le coeur de rat.