title: [Changes in the larynx of rats induced by chemical carcinogens].
abstract: Carcinogenesis of the larynx induced by local application of 0.5% DMBA acetone solution or 1% methylnitrosourea acetone solution twice a week for 5-6 months was studied in 40 rats. The rats were killed by means of ether inhalation 7-12 months later. The carcinogens have induced epithelial hyperplasia, squamous cell metaplasia, acanthosis, dyskeratosis and hyperkeratosis, Epithelial downgrowths and papillomas have developed in 60-80% of animals. DMBA proved to be a stronger carcinogenic agent.
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D007822:Laryngeal Neoplasms / Q000139:chemically induced / Q000473:pathology; D007830:Larynx / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008770:Methylnitrosourea; D009603:Nitroso Compounds / Q000633:toxicity*; D011083:Polycyclic Compounds / Q000633:toxicity*; D051381:Rats; D013997:Time Factors
chemical_list: D009603:Nitroso Compounds; D011083:Polycyclic Compounds; D015127:9,10-Dimethyl-1,2-benzanthracene; D008770:Methylnitrosourea
vernacular_title: Izmeneniia v gortani krys, vyzvannye khimicheskimi kantserogenami.