Recombinant murine gamma interferon inhibits Chlamydia trachomatis serovar L1 in vivo.
Chlamydia trachomatis serovar L1 injected intravenously in mice resulted in systemic nonlethal infections of the animals. Treatment of mice with recombinant murine gamma interferon resulted in a decrease in the number of infectious C. trachomatis organisms recovered from the lungs, spleens, and livers as well as in a decrease of the inflammatory reaction in those organs when assessed 3 and 5 days after challenge.
D000818:Animals; D002690:Chlamydia Infections / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D002692:Chlamydia trachomatis / Q000254:growth & development*; D005260:Female; D007371:Interferon-gamma / Q000494:pharmacology*; D008099:Liver / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D011994:Recombinant Proteins / Q000494:pharmacology*
D011994:Recombinant Proteins; D007371:Interferon-gamma