[Reduced sensitivity of the heart ventricle of obese Zucker rats to isoprenaline].
In heart of genetically obese (fa/fa) 12-week-old Zucker rats, ventricle contractility (4 mM KCl medium), amplitude and duration of slow action potentials (14 mM KCl medium) were less increased by isoprenaline than in heart of non obese (Fa/fa) rats. This difference could be related to a lower reactivity of beta-adrenoceptors in obese rat heart.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D007545:Isoproterenol / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D009765:Obesity / Q000503:physiopathology*; D051381:Rats; D011922:Rats, Mutant Strains; D011924:Rats, Zucker; D016276:Ventricular Function
D007545:Isoproterenol
Sensibilité réduite du ventricule cardiaque de rat Zucker obèse en réponse à l'isoprénaline.