title: An enhancer factor defect in a mutant Burkitt lymphoma cell line.
abstract: RJ 2.2.5 is an immunoselected mutant of the Burkitt lymphoma line Raji. It fails to display MHC class II antigens at the cell surface due to a transcriptional defect. We have identified the function of a regulatory factor that is defective in RJ 2.2.5 cells; this factor is absolutely required for the activity of an MHC class II gene enhancer.
mesh_terms: D004268:DNA-Binding Proteins / Q000502:physiology*; D004742:Enhancer Elements, Genetic; D005802:Genes, MHC Class II; D006681:HLA-D Antigens / Q000235:genetics*; D006801:Humans; D012045:Regulatory Sequences, Nucleic Acid; D014407:Tumor Cells, Cultured
chemical_list: D004268:DNA-Binding Proteins; D006681:HLA-D Antigens