title: [The topography of P300 in neuropsychiatric pharmacotherapy. III. Cognitive P300 fields in an organic psychosyndrome (Wilson's disease) before and during treatment with D-penicillamine].
abstract: Beside senile dementia of Alzheimer's type (SDAT) there are also dementive syndromes due to a disturbance in metabolism. In a case with a disturbance of copper metabolism (Wilson's disease) a similar P300-pattern was found as described in SDAT with signs of a frontal amplitude elevation. Under therapy with d-penicillamine the frontal P300-positivity moved from frontal to parietal structures. Combined with this migration was an amelioration in cognitive function. This single-case study underlines the significance of P300-topography in the evaluation of therapy effects in dementive disorders.
mesh_terms: D000328:Adult; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D004569:Electroencephalography; D006527:Hepatolenticular Degeneration / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use*
chemical_list: D010396:Penicillamine
vernacular_title: Topographie der P300 in der Neuropsychiatrischen Pharmakotherapie. III. Kognitive P300-Felder beim organischen Psychosyndrom (Morbus Wilson) vor und während einer Therapie mit D-Penicillamin.