Differential control of proto-oncogene c-myc and c-fos expression in lymphocytes and fibroblasts.
In lymphocytes stimulated with the mitogen phytohaemagglutinin, an inhibitor of the enzyme ADP-ribosyltransferase (ADPRT) completely blocks the proliferative response and the increase in expression of the proto-oncogene c-myc without affecting c-fos significantly. Conversely, in fibroblasts the serum-induced growth is not affected by the ADPRT inhibitor, and both oncogenes are dramatically super-induced. Hence there are differences between lymphocyte and fibroblast early responses to mitogenic stimulation and also between regulation of c-fos and c-myc gene expression.
D001549:Benzamides / Q000494:pharmacology; D002478:Cells, Cultured; D004587:Electrophoresis, Agar Gel; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000378:metabolism*; D009857:Oncogenes; D010835:Phytohemagglutinins / Q000494:pharmacology; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger / Q000032:analysis
D001549:Benzamides; C000715470:MAS1 protein, human; D010835:Phytohemagglutinins; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger; C025159:3-methoxybenzamide