Intravitreal liposome-encapsulated trifluorothymidine in a rabbit model.
Two groups of albino rabbits received an intravitreal injection of liposome-encapsulated trifluorothymidine. One group underwent a clearance study using high-performance liquid chromatography. The results of this study demonstrated a prolonged vitreal drug level within the range of ID50 for many strains of herpesvirus and human cytomegalovirus (CMV) at 28 days after injection. The eyes of another group were evaluated with preoperative and postoperative indirect ophthalmoscopy, electroretinography, and histologic examination. No retinal toxicity was found.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004596:Electroretinography; D008081:Liposomes / Q000008:administration & dosage*; D011817:Rabbits; D013936:Thymidine / Q000031:analogs & derivatives*; D013997:Time Factors; D014271:Trifluridine / Q000493:pharmacokinetics*; D014822:Vitreous Body / Q000378:metabolism* / Q000473:pathology
D008081:Liposomes; D014271:Trifluridine; D013936:Thymidine