Immunogenicity of liposomes and iscoms containing the major outer membrane protein of Neisseria gonorrhoeae: influence of protein content and liposomal bilayer composition.
The influences of Neisseria gonorrhoeae protein IB content and bilayer composition of liposomes and protein content of iscoms on immunogenicity were investigated. Changes in the protein content of liposomes did not influence the immunoglobulin G response, whereas the response was lowered when the amount of protein in iscoms was increased. Bilayer composition only influenced the primary immunoglobulin G response; immunological memory was not affected.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000008:administration & dosage / Q000276:immunology*; D003102:Colloids; D008051:Lipid Bilayers / Q000276:immunology*; D008081:Liposomes / Q000008:administration & dosage / Q000276:immunology*; D051379:Mice; D008823:Micelles; D009344:Neisseria gonorrhoeae / Q000276:immunology*; D013329:Structure-Activity Relationship
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D003102:Colloids; D008051:Lipid Bilayers; D008081:Liposomes; D008823:Micelles