Humoral immunity in disseminated Aspergillus terreus infection in the dog.
Aspects of humoral immunity were studied in 17 dogs with disseminated aspergillosis (16 cases Aspergillus terreus, 1 case Aspergillus flavipes). All dogs had markedly raised serum IgG levels by single radial immunodiffusion (range 1500-6000 mg dl-1). Despite this, serum antibody to A. terreus was demonstrated in only 7/16 cases by agar gel diffusion, 9/16 cases by counter immunoelectrophoresis, 10/16 by ELISA and 11/16 by an indirect immunofluorescence assay. Serum antibody was also detected in 2/5 clinically normal relatives of 2 cases, indicating previous exposure or subclinical infection.
D000818:Animals; D000908:Antibodies, Fungal / Q000096:biosynthesis*; D000946:Antigens, Fungal / Q000276:immunology; D001228:Aspergillosis / Q000276:immunology / Q000662:veterinary*; D001230:Aspergillus / Q000276:immunology*; D003378:Counterimmunoelectrophoresis; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000096:biosynthesis; D007136:Immunoglobulins / Q000096:biosynthesis*
D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D007074:Immunoglobulin G; D007136:Immunoglobulins