Spontaneous synaptic potentials in dopamine-denervated neostriatal neurons.
Intracellular spontaneous activity was recorded in neostriatal slices from rats with 6-hydroxydopamine-induced lesion of the left nigrostriatal dopaminergic system. Recordings were made at different times after denervation. Dopaminergic denervation caused the appearance of spontaneous synaptic potentials, which were present even after 8 months. The results suggest a tonic inhibitory influence of the dopaminergic innervation on the synaptic input of neostriatal neurons.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D006892:Hydroxydopamines; D066298:In Vitro Techniques; D009434:Neural Pathways / Q000502:physiology; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D013997:Time Factors; D014403:Tubocurarine / Q000494:pharmacology
D006892:Hydroxydopamines; D016627:Oxidopamine; D004298:Dopamine; D014403:Tubocurarine