title: Modulation by neonatal thymectomy of the reproductive axis in male and female rats during development.
abstract: The effects of neonatal thymectomy, at 3 days of age, on parameters of the reproductive axis were examined in male and female Sprague-Dawley rats. Gonadal and accessory sex tissue (male: epididymis, seminal vesicle, and ventral prostate; female: uterus) weights as well as anterior pituitary, spleen, and adrenal weights were determined in the thymectomized and sham-thymectomized animals at 20, 30, 40, 50, 60, and 90 days of age. Plasma gonadotropin concentrations as well as pituitary content of the gonadotropins and prolactin were assessed at each of these time intervals. No significant difference in gonad and accessory sex tissue weights was detected in thymectomized versus sham-operated controls at each of these times. Adrenal weights were increased in thymectomized animals compared with controls at 50 days of age and older in male rats and at 90 days in females. Spleen weights were decreased in the thymectomized males at 50 and 60 days of age. Thymectomy did not affect the spleen weight of females. Plasma concentrations of gonadotropins were unaffected in thymectomized males but were altered in females during the pre- and peripubertal period (Days 20-40). Vaginal opening, however, occurred at the same time in the thymectomized and control females. Pituitary gonadotropin and prolactin content were unaffected by thymectomy of the females, except at 90 days when pituitary luteinizing hormone (LH) content was lower in thymectomized than in control animals. LH and prolactin content were significantly reduced in the males at 60 and 90 days of age. These results demonstrate that there are sexual differences in the effects of thymectomy on parameters of the reproductive axis.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000032:analysis / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000032:analysis / Q000097:blood / Q000502:physiology*; D007986:Luteinizing Hormone / Q000032:analysis / Q000097:blood; D008297:Male; D009929:Organ Size; D011388:Prolactin / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction; D012737:Sex Factors; D013934:Thymectomy
chemical_list: D006065:Gonadotropins, Pituitary; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone