title: Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.
abstract: Interleukin-6 (IL-6/BSF-2/IFN beta 2) is a multifunctional cytokine that regulates the growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. A complementary DNA encoding the human IL-6 receptor (IL-6-R) has now been isolated. The IL-6-R consists of 468 amino acids, including a signal peptide of approximately 19 amino acids and a domain of approximately 90 amino acids that is similar to a domain in the immunoglobulin (Ig) superfamily. The cytoplasmic domain of approximately 82 amino acids lacks a tyrosine/kinase domain, unlike other growth factor receptors.
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005796:Genes; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D008969:Molecular Sequence Data; D011971:Receptors, Immunologic / Q000235:genetics; D019947:Receptors, Interleukin-6; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
chemical_list: D007145:Immunoglobulin kappa-Chains; D011971:Receptors, Immunologic; D019947:Receptors, Interleukin-6; D004247:DNA