Osteoarthritis as a remodeling process.
Osteoarthritic remodeling involves intimately related events in 3 compartments of the joint surface: the cartilage, osteochondral junction, and capsular tissues. Despite common wisdom, it is difficult to identify abnormalities confined to the cartilage. This places theoretical constraints on what can be accomplished by antiproteases in the treatment of degenerative joint disease.
D000328:Adult; D000368:Aged; D001862:Bone Resorption / Q000473:pathology; D002358:Cartilage, Articular / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D009999:Ossification, Heterotopic / Q000473:pathology; D010003:Osteoarthritis / Q000209:etiology / Q000473:pathology*