Effect of PSK, a protein-bound polysaccharide from Coriolus versicolor, on drug-metabolizing enzymes in sarcoma-180 bearing and normal mice.
The effects of PSK and Propionibacterium acnes (anaerobic Corynebacterium) on hepatic drug-metabolizing enzymes were studied using sarcoma-180 bearing and non-tumor bearing mice. PSK had no influence on aminopyrine N-demethylase and aniline hydroxylase activities, cytochrome P-450 concentration in hepatic microsomes, and the reductase activity of cytochrome c in normal mice. The content of cytochrome P-450 was not significantly reduced in S-180 bearing mice. On the other hand, P. acnes administration significantly decreased the amount of cytochromes P-450 and b5 and aminopyrine N-demethylase activity. When FT-207 (Tegafur) was administered orally to S-180 bearing mice combined with the immunoadjuvants, only P. acnes significantly reduced the 5-FU levels in the serum and some organs.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D005260:Female; D005472:Fluorouracil / Q000493:pharmacokinetics; D008099:Liver / Q000201:enzymology; D051379:Mice; D008813:Mice, Inbred ICR; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011425:Propionibacterium acnes / Q000276:immunology; D011509:Proteoglycans / Q000494:pharmacology*; D012510:Sarcoma 180 / Q000201:enzymology*; D005641:Tegafur / Q000378:metabolism
D000276:Adjuvants, Immunologic; D000903:Antibiotics, Antineoplastic; D004364:Pharmaceutical Preparations; D011509:Proteoglycans; D005641:Tegafur; C010770:polysaccharide-K; D005472:Fluorouracil