Heparin inhibits infectivity of human immunodeficiency virus in vitro.
The infectivity of human immunodeficiency virus (HIV) was inhibited by heparin, though de-N-sulfated heparin and heparin pretreated with protamine sulfate were hardly inhibitory. There was a correlation between the anticoagulant activities and anti-HIV activities of heparin-related compounds.
D002478:Cells, Cultured; D006678:HIV / Q000187:drug effects* / Q000472:pathogenicity; D006493:Heparin / Q000494:pharmacology*; D011479:Protamines / Q000494:pharmacology
D011479:Protamines; D006493:Heparin