Chronic consumption of ethanol increases glucose oxidation in isolated cerebral tissue of rat.
Tolerance to ethanol was induced in male Wistar rats by adding 15% ethanol to the drinking water for 3 and 9 months. The oxidation of [U-14C]glucose was measured in cerebral cortex prisms. 14CO2 production in prisms for ethanol-treated animals was markedly increased when compared to controls. Neither a single injection of a low dose of ethanol nor a comparable concentration of ethanol in vitro had this stimulatory effect.
D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D002245:Carbon Dioxide / Q000096:biosynthesis; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002245:Carbon Dioxide; D000431:Ethanol; D005947:Glucose