title: Active and passive transport of sodium and potassium ions in erythrocytes of severely malnourished Jamaican children.
abstract: Erythrocytes of normal and malnourished children, both marasmic and oedematous (kwashiorkor), were equilibrated in standard incubation medium and their ion transport via the Na/K pump and the pathways of passive permeation were measured as unidirectional fluxes of 86Rb (as a congener of K) and 22Na. Cells of children with kwashiorkor exhibited a 65 per cent higher ouabain-sensitive K(Rb) influx ('pump rate') than those of normal or marasmic children. When allowance was made for cytoplasmic Na concentration, the pump rate was slower in younger (12 months and under) normal children than in older children. Judged by the same criterion, cells of older marasmic children also had slower steady-state pump activity. The passive permeation of K through the residual 'leak' pathway (ie, ouabain-and-bumetanide-insensitive influx) and Na permeation (ouabain-and-bumetanide-insensitive Na efflux) were greater in malnourished children than in normal children by a factor of two or more. During treatment for malnutrition, both Na-pump activity and ouabain binding increased rapidly in marasmic children. Passive permeation did not return to normal levels in malnourished children during the period of hospitalization.
mesh_terms: D000367:Age Factors; D001692:Biological Transport; D001693:Biological Transport, Active; D002463:Cell Membrane Permeability; D002675:Child, Preschool; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007563:Jamaica; D007732:Kwashiorkor / Q000097:blood* / Q000175:diagnosis / Q000178:diet therapy; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000097:blood*; D011502:Protein-Energy Malnutrition / Q000097:blood* / Q000175:diagnosis / Q000178:diet therapy; D012964:Sodium / Q000097:blood*
chemical_list: D010042:Ouabain; D012964:Sodium; D011188:Potassium