Phenothiazine-induced systemic lupus erythematosus with superior vena cava syndrome: case report and review of the literature.
Phenothiazine-induced lupus with circulating anticoagulant (CAC) has been reported infrequently, and is rarely associated with significant symptoms. We describe a patient who we suspect had perphenazine-induced lupus erythematosus with CAC. She had recurrent episodes of venous thrombosis and ultimately developed superior vena cava syndrome. The relationships among phenothiazine-induced lupus, CAC, and thrombosis are discussed.
D000328:Adult; D000856:Anorexia Nervosa / Q000188:drug therapy; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology; D002318:Cardiovascular Diseases / Q000139:chemically induced; D003863:Depression / Q000188:drug therapy; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000139:chemically induced*; D010640:Phenothiazines / Q000009:adverse effects* / Q000627:therapeutic use; D013577:Syndrome; D014683:Vena Cava, Superior
D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor; D010640:Phenothiazines; C031637:phenothiazine