Relationship between 7,12-dimethyl- and 7,8,12-trimethylbenz[a]anthracene DNA adduct formation in hematopoietic organs and leukemogenic effects.
The leukemogens 7,12-dimethylbenz[a]anthracene (DMBA) and 7,8,12-trimethylbenz[a]anthracene (TMBA) bind covalently in vivo to DNA of Long-Evans rats in the hematopoietic organs, spleen and bone marrow, and in the liver, a non-target organ. Both TMBA and DMBA depleted bone marrow cells and both agents bound persistently to the DNA of bone marrow and of liver, and less to that of spleen. The three main DMBA:deoxyribonucleoside adducts in spleen, bone marrow and liver were the same as those found previously in the liver (Dipple et al. (1983) Cancer Res., 43, 4132). There were no organ-specific or age-dependent differences in the relative amounts of adducts formed. There appears to be no direct correlation between the susceptibility of an organ to carcinogenesis and the nature and relative amount of the specific adducts formed, at least for the three organs studied here.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D005260:Female; D006413:Hematopoietic System / Q000378:metabolism*; D007942:Leukemia, Experimental / Q000139:chemically induced; D008099:Liver / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000378:metabolism
C029538:7,8,12-trimethylbenz(a)anthracene; D015127:9,10-Dimethyl-1,2-benzanthracene; D004247:DNA