title: [Oligoasthenoteratozoospermia in valproic acid therapy].
abstract: We report on 2 cases of oligoasthenoteratozoospermia due to therapy with valproic acid, which had been given on account of mal grand epilepsy in both cases. On first examination of the patients, the daily dose of valproic acid amounted to more than 1000 mg. After reduction to 150 mg daily, the sperm parameters returned to normal. One patient succeeded in pregnancy after 5 years of childless marriage.
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy*; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced; D008297:Male; D009845:Oligospermia / Q000139:chemically induced*; D013076:Sperm Count / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014635:Valproic Acid
vernacular_title: Oligoasthenoteratozoospermie unter Valproinsäuretherapie.