title: [Comparison of 2 modes of treatment of diabetic ketoacidosis in children].
abstract: In two groups of children with diabetic ketoacidosis, the effects of intramuscular insulin injections associated with intensive rehydration and alkalisation were compared with low-dose continuous intravenous infusion associated with well-controlled fluid and electrolyte therapy. Although correction of ketoacidosis was as effective with both methods, the second appeared to offer several advantages: 1. More progressive normalization of metabolic parameters; 2. Reduced risks of hypoglycemia and hypokaliemia; 3. Easier control of the decrease in plasma glucose levels; 4. Better correction of hyponatremia; 5. More gradual increase in pH values. These results confirmed that low-dose continuous insulin infusion with proper monitoring of fluid and electrolyte replacement was a safe, simple and effective treatment of diabetic ketoacidosis in children.
mesh_terms: D000137:Acid-Base Imbalance / Q000628:therapy; D000293:Adolescent; D001639:Bicarbonates / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D016883:Diabetic Ketoacidosis / Q000628:therapy*; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007273:Injections, Intramuscular; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D013997:Time Factors
chemical_list: D001639:Bicarbonates; D007328:Insulin
vernacular_title: Comparaison de deux modes de traitement de l'acidocétose diabétique de l'enfant.