Thyroxine-binding globulin deficiency re-examined.
Seven sera, previously categorised as completely deficient in thyroxine-binding globulin (TBG) by an immunoelectrophoretic technique, were re-examined with a sensitive ELISA method. Only one of the sera was confirmed completely deficient by ELISA. The remaining six contained 0.08-0.19 mg/l. The protein was immunologically identical with 'normal' TBG, could bind to thyroxine and had the correct mobility in reverse-flow electrophoresis. Complete TBG deficiency may therefore be rare.
D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007122:Immunoelectrophoresis; D008297:Male; D013974:Thyroxine / Q000494:pharmacology; D013975:Thyroxine-Binding Proteins / Q000172:deficiency*
D013975:Thyroxine-Binding Proteins; D013974:Thyroxine