Potential inhibitors of platelet aggregation from plant sources, III.
3,4-Dihydroxybenzoic acid (DBA) was isolated from Acanthopanax senticosus as an antiplatelet aggregatory substance. This paper also reports the results of the investigations on the structural activity relationships among the various dihydroxybenzoic acid derivatives against rat platelet aggregations induced by ADP (adenosine 5'-diphosphate), AA (arachidonic acid), or collagen.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003094:Collagen / Q000494:pharmacology; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000032:analysis*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
D001095:Arachidonic Acids; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate; D003094:Collagen