Use of a pharmacokinetic model to characterize the thyrotropin (TSH) and prolactin (PRL) response to thyrotropin-releasing hormone (THR) in man.
On the basis of a pharmacokinetic model using the data of a TRH test and without the use of radio-isotope tracers, a simple procedure of estimation of PRL and TSH TRH-stimulated release and elimination half-lives is presented. TRH tests were performed in 33 healthy subjects and their data were used to calculate the kinetic parameters of each subject. Elimination half-lives of TSH and PRL were found to be respectively (mean +/- SD in min) 63 +/- 7.4 and 35 +/- 2.8. Release half-lives were 8.2 +/- 1.3 for TSH and 5 +/- 0.4 for PRL. The usefulness of the procedure in the evaluation of drug effects on pituitary secretion in man and the comparison with the literature data are discussed.
D000328:Adult; D000368:Aged; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011388:Prolactin / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone / Q000493:pharmacokinetics / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D013972:Thyrotropin