Effects of morphine and calcium antagonists on plasma glucose in male rats.
Subcutaneous administration of morphine sulfate (4-16 mg/kg) did not significantly alter the plasma glucose concentration in fasted adult male Fischer-344 rats. All rats treated with calcium channel antagonists, verapamil or diltiazem (10 mg/kg, with or without morphine), showed marked and significant hyperglycemia, persisting at high levels throughout the 2 h experiment.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004347:Drug Interactions; D007700:Kinetics; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D014700:Verapamil / Q000494:pharmacology*
D001786:Blood Glucose; D009020:Morphine; D014700:Verapamil