title: [Infusion treatment with nitrites of patients with acute myocardial infarct and unstable angina pectoris].
abstract: The results of prolonged infusion treatment with Trinitrosan and Isoket of 29 patients with acute myocardial infarction and unstable angina pectoris are reported. The drug action on the anginal syndrome, accompanying cardiac failure, heart rate and arterial tension is analysed. The action on the dynamic of enzyme activity and of the electrocardiograms during the treatment is compared with a control group of healthy persons. The results show full therapeutic efficacy in relation to the anginal syndrome and cardiac failure without any other medication in 1/2 of the patients; a partial antianginal effect is found in 1/4 of the patients treated. The examinations did not show any favourable action of the drugs on the enzymes and ECGs followed up in dynamics. The nitrites in the doses applied show no negative action on the heart rate and arterial tension and no special hemodynamics control is required.
mesh_terms: D000787:Angina Pectoris / Q000188:drug therapy*; D000789:Angina, Unstable / Q000188:drug therapy* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D004341:Drug Evaluation; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007548:Isosorbide Dinitrate / Q000008:administration & dosage*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D005996:Nitroglycerin / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D005996:Nitroglycerin; D007548:Isosorbide Dinitrate
vernacular_title: Infuzionno lechenie s nitriti na bolni s ostŭr miokarden infarkt i nestabilna angina pectoris.