Anomeric specificity of D-glucose metabolism in human erythrocytes.
The metabolism of D-[5-3H]glucose and D-[U-14C]glucose displays anomeric specificity in human erythrocytes. At close-to-physiological hexose concentrations, pure beta-D-[5-3H]glucose is metabolized at a higher rate than the corresponding pure alpha-anomer in most, but not all, subjects. This situation represents a mirror image of that found in rat erythrocytes. The anomeric preference is modulated by the extracellular concentration of D-glucose and may differ for distinct metabolic variables. The anomeric specificity of D-glucose metabolism remains operative, whether at low or normal temperature, even in erythrocytes exposed to equilibrated D-glucose.
D001786:Blood Glucose / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D066298:In Vitro Techniques; D010084:Oxidation-Reduction; D013696:Temperature
D001786:Blood Glucose; D002245:Carbon Dioxide; D006861:Hydrogen Peroxide