Grafted noradrenergic neurons suppress seizure development in kindling-induced epilepsy.
Norepinephrine-rich cell suspensions, prepared from the locus coeruleus region of rat fetuses, were grafted bilaterally into the hippocampus of rats made hypersensitive to hippocampal kindling by a neurotoxic lesion of the central catecholamine system. The animals with grafts showed a marked suppression of the onset and progression of kindling-induced epilepsy, and this effect was correlated with the degree of graft-derived noradrenergic innervation of the host hippocampal formation. We conclude that grafted neurons can modulate the excitability of epileptic brain regions.
D000320:Adrenergic Fibers / Q000502:physiology* / Q000637:transplantation; D000818:Animals; D004827:Epilepsy / Q000473:pathology / Q000503:physiopathology*; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology; D006892:Hydroxydopamines / Q000633:toxicity; D007696:Kindling, Neurologic; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D016627:Oxidopamine; D051381:Rats
D006892:Hydroxydopamines; D016627:Oxidopamine; D009638:Norepinephrine