title: [Influence of different types of experimental obesity on resistance of the mouse to infection by Salmonella typhimurium and Klebsiella pneumoniae].
abstract: Resistance to infections inducing two types of immune response, humoral and cell-mediated, has been measured in mice after Salmonella typhimurium and Klebsiella pneumoniae inoculation; the animals exhibited different kinds of obesity: genetic, ob/ob and db/db mutants, induced by fat diet or gold thioglucose (aurothioglucose) injection (determining obesity of central origin). Klebsiella infection was aggravated in all types of obesity. Salmonella infection was aggravated in genetically diabetic and dietary-obese mice. The two kinds of genetically obese mice show an important functional decrease in splenic lymphocytes. In contrast, aurothioglucose-obese mice were more resistant than controls.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D006051:Aurothioglucose; D003920:Diabetes Mellitus / Q000276:immunology; D003921:Diabetes Mellitus, Experimental / Q000276:immunology; D004041:Dietary Fats; D005260:Female; D007111:Immunity, Cellular; D007710:Klebsiella Infections / Q000276:immunology*; D007711:Klebsiella pneumoniae; D051379:Mice; D008817:Mice, Mutant Strains; D008820:Mice, Obese; D009765:Obesity / Q000209:etiology / Q000276:immunology*; D012481:Salmonella Infections, Animal / Q000276:immunology*; D012486:Salmonella typhimurium
chemical_list: D004041:Dietary Fats; D006051:Aurothioglucose
vernacular_title: Influence de divers types d'obésité expérimentale sur la résistance de la souris à l'infection par Salmonella typhimurium et Klebsiella pneumoniae.