Application of the unilateral 6-hydroxydopamine rat model of rotational behavior to the study of conditioned drug effects.
In rats with unilateral 6-hydroxydopamine lesions of the substantia nigra apomorphine reliably induces a response of contralateral rotation. The present study shows that this response can readily be conditioned to a test environment which the rats are briefly exposed to during the onset of the apomorphine-induced rotation. This conditioned response can be repeatedly conditioned, extinguished, and differentially conditioned, thereby providing a useful behavioral model for the study of the conditioning of drug-induced movements.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000502:physiology*; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D008959:Models, Neurological; D009043:Motor Activity / Q000502:physiology*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D012399:Rotation; D013239:Stereotyped Behavior / Q000187:drug effects; D013378:Substantia Nigra / Q000187:drug effects*
D006892:Hydroxydopamines; D016627:Oxidopamine; D001058:Apomorphine