title: Enterococcal superinfection in patients treated with ciprofloxacin.
abstract: Two patients developed serious enterococcal superinfection following therapy with intravenous ciprofloxacin. The strains causing bacteraemia were susceptible to low concentrations of ciprofloxacin when tested at a standard inoculum. However, at an inoculum of 1 X 10(7) cfu/ml they were resistant to high concentrations of ciprofloxacin. Our data suggest that ciprofloxacin should not be used to treat patients with serious enterococcal infection and that patients treated with ciprofloxacin should be monitored carefully for the development of enterococcal superinfection.
mesh_terms: D000328:Adult; D000368:Aged; D002939:Ciprofloxacin / Q000009:adverse effects* / Q000627:therapeutic use; D013293:Enterococcus faecalis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D011552:Pseudomonas Infections / Q000150:complications / Q000188:drug therapy; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology; D013290:Streptococcal Infections / Q000209:etiology* / Q000382:microbiology
chemical_list: D002939:Ciprofloxacin