title: Chromium chloride induces chromosomal aberrations in human lymphocytes via indirect action.
abstract: The aim of this study was to examine the possible clastogenic effects of trivalent chromium chloride (CrCl3) as the results in the literature are non-conclusive. Under the conditions used in this study Cr(III) induces chromosomal aberrations in phytohemagglutinin(PHA)-stimulated human lymphocytes. This activity, however, is suppressed by the antioxidants superoxide dismutase (SOD) (scavenger of O-.2), the SOD-like agents, catalase and mannitol (specific scavenger of OH.). The possibility that oxygen free radicals could evolve through stimulation of the arachidonic acid cascade is suggested using suitable inhibitors.
mesh_terms: D015117:5,8,11,14-Eicosatetraynoic Acid / Q000494:pharmacology; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000502:physiology; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D002712:Chlorides; D002857:Chromium / Q000633:toxicity*; D017608:Chromium Compounds; D002869:Chromosome Aberrations; D005609:Free Radicals; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects; D009637:Masoprocol / Q000494:pharmacology; D010100:Oxygen
chemical_list: D001095:Arachidonic Acids; D002712:Chlorides; D017608:Chromium Compounds; D005609:Free Radicals; D002857:Chromium; D015117:5,8,11,14-Eicosatetraynoic Acid; D016718:Arachidonic Acid; D009637:Masoprocol; C017133:chromous chloride; D010100:Oxygen; D007213:Indomethacin