title: Extended latency of the cortical component of the somatosensory-evoked potential accompanying moderate increases in cerebral blood flow during systemic hypoxia in cats.
abstract: In 24 adult cats, the somatosensory-evoked potential (SEP) and cerebral blood flow (CBF) were measured under paralyzed, anesthetized conditions during exposure to two different ventilatory regimens. Group I cats (ventilated from 20 to 2% oxygen) responded with a significant increase in white matter blood flow from 25.0 +/- 7.8 to 43.8 +/- 10.5 ml/100 g/min recorded at 7% O2. Gray matter blood flows in these animals increased but not to significant levels above the control blood flow measured at 20%. No significant changes in blood flow were observed in group II animals ventilated over the range of 25-3% oxygen as gray matter rose slightly (but not significantly) with hypoxia and white matter flows remained at levels of 25-30 ml/100 g/min. The latency of the cortical component of the SEP was related to the degree of hypoxia. For both groups, significant extensions in the latency to the occurrence of the cortical component of the SEP (normalized to the % of control SEP) occurred in each case (P less than 0.05). An inverse, linear relationship existed between the latency to the appearance of cortical component (ms) and the percentage oxygen concentration of the ventilatory mixture. No significant changes in thalamocortical conduction times were found, which indicates that hypoxia may have generalized effects on the synaptic pathways supporting the conduction of the SEP. The variation in blood flow and the latency of the cortical component observed between groups I and II may reflect the oxygen concentration used at the beginning of the experiment (25 vs 20%) and the gradations between them vs 3 and 2%.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002415:Cats; D002540:Cerebral Cortex / Q000502:physiology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D005073:Evoked Potentials, Somatosensory; D005260:Female; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D010100:Oxygen / Q000097:blood; D012039:Regional Blood Flow
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen