[Tegafur and 5-FU concentrations in cancerous and normal tissues in nude mice after oral administration of UFT].
Tegafur and 5-fluorouracil (5-FU) concentrations in blood, tumor, kidney and liver tissues of nude mice implanted with human urogenital carcinoma were determined after oral administration of UFT. The results were as follows: The concentration of tegafur in serum and other tissues rose quickly reading to the peak levels by 15 minutes after administration of UFT, then decreasing gradually. The concentration of 5-FU in serum, liver and kidney showed similar changes, but concentration of tumor tissues were maintained high until 2 hours after administration. These results suggest that coadministration of uracil with tegafur increase the antitumor activity of tegafur.
D000818:Animals; D004338:Drug Combinations; D005260:Female; D005472:Fluorouracil / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D005641:Tegafur / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution; D014183:Transplantation, Heterologous; D014498:Uracil / Q000008:administration & dosage; D014571:Urologic Neoplasms / Q000378:metabolism*
D004338:Drug Combinations; D005641:Tegafur; D014498:Uracil; D005472:Fluorouracil