[Age characteristics of the hypoglycemic effect of glibenclamide].
A comparative study of glibenclamide (G) effect on glucose and IRI levels in rats aged 4 to 5 and 24 to 28 mos. following 18 h starvation was performed. One hour after administration of G at a dose of up to 1 mg/kg of body mass glycemia did not change but in 3 and 5 h it decreased more markedly in old rats. The elevation of a G dose up to 5 mg/kg of body mass raised the hypoglycemic effect in young animals causing no changes in old rats. Glibenclamide at a dose of 1 mg/kg of body mass did not change the IRI level in the young rats' blood and increased it in the old rats 2-3 h after administration. A dose of 5 mg determined a higher IRI level in the young rats' blood and decreased this effect in the old animals.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005905:Glyburide / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D005905:Glyburide
Vozrastnye osobennosti gipoglikemicheskogo éffekta glibenklamida.