[Effect of verapamil, cromoglycate and dimedrol on the survivability of mice in endotoxic shock].
The trial has been performed on blocking the potentiation of the lethal action of Sh. Sonnei endotoxin isolated using the agents possessing antiaggregation and antimediator properties--verapamil, cromoglycate and diphenhydramine. It was shown that LD50 of endotoxin increased 2-2.5-fold, provided there were 3 drug injection 1, 4 and 9 hours after endotoxin administration. The survival of mice at 100% level of mortality was also increased 2-2.5-fold. With endotoxin administered together with the first drug injection, the drugs were ineffective. In case endotoxin was administered 3 times at a 4-hour interval prophylactic and therapeutic effects of the drugs and their combinations have been observed.
D000818:Animals; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000627:therapeutic use*; D004155:Diphenhydramine / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004731:Endotoxins / Q000008:administration & dosage / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D012764:Shigella sonnei; D012772:Shock, Septic / Q000188:drug therapy* / Q000401:mortality; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage / Q000627:therapeutic use*
D004731:Endotoxins; D004155:Diphenhydramine; D014700:Verapamil; D004205:Cromolyn Sodium
Vliianie verapamila, khromoglikata i dimedrola na vyzhivaemost' mysheĭ pri éndotoksicheskom shoke.