Proteolytic degradation of insulin and glucagon in rat brain during ontogenesis.
The degradation of insulin and glucagon was investigated in rat brain, kidney, and liver during postnatal ontogenesis. It was found that a maximal activity around 13 d is unique for CNS and differs remarkably from time-course in liver and kidney. It is concluded that this result supports the hypothesis of a growth promoting role of insulin in developing rat brain.
D000375:Aging; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000254:growth & development*; D003600:Cytosol / Q000201:enzymology; D007339:Insulysin / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology / Q000254:growth & development; D008099:Liver / Q000201:enzymology / Q000254:growth & development; D009928:Organ Specificity; D010447:Peptide Hydrolases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D010447:Peptide Hydrolases; D007339:Insulysin