Urinary beta-1-galactosyl-0-hydroxylysine (GH) as a marker of collagen turnover of bone.
beta-1-galactosyl-0-hydroxylysine (GH) was measured in the urine of 59 women and 48 men, aged 30-79 years, by High Performance Liquid Chromatography (HPLC) of the dansylated derivative. Vertebral mineral density, measured by quantitative computed tomography (QCT), and urinary GH were inversely correlated (r = -0.74; P less than 0.001). High rate of bone mineral loss is associated with a high urinary GH excretion. Measurement of GH in urine provides a simple and noninvasive method for the evaluation of the extent of bone resorption in large groups of subjects and appears to be more specific than urinary hydroxyproline excretion.
D000375:Aging / Q000652:urine; D001842:Bone and Bones / Q000378:metabolism*; D002940:Circadian Rhythm; D003094:Collagen / Q000032:analysis / Q000378:metabolism*; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D006901:Hydroxylysine / Q000031:analogs & derivatives* / Q000502:physiology / Q000652:urine; D008297:Male; D008593:Menopause / Q000652:urine; D008903:Minerals / Q000032:analysis; D012016:Reference Values; D012727:Sex Characteristics
D008903:Minerals; D006901:Hydroxylysine; C007817:galactosylhydroxylysine; D003094:Collagen; D003404:Creatinine