A complex translocation at the murine kappa light-chain locus.
We have previously reported that a segment of DNA from a murine plasmacytoma comprises DNA from three chromosomes, the immunoglobulin kappa light-chain locus on chromosome 6, the S mu locus on chromosome 12, and a region on chromosome 15. We now report that the reciprocal product contains DNA from only the kappa locus and chromosome 15 and not from S mu. We conclude that a complex series of events, including both a transposition of DNA and a translocation between chromosomes, generated these imperfect reciprocal products.
D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D005803:Genes, Immunoglobulin; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D051379:Mice; D010954:Plasmacytoma / Q000276:immunology; D014178:Translocation, Genetic
D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains