Studies on WF-3681, a novel aldose reductase inhibitor. II. Structure determination and synthesis.
The structure of WF-3681, a novel aldose reductase inhibitor produced by Chaetomella raphigera Swift No. 3681, was deduced to be 1 on the basis of its spectroscopic and chemical evidences and confirmed by a total synthesis starting from (E)-5-phenyl-4-pentenol.
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D055598:Chemical Phenomena; D002621:Chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis; D005663:Furans / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D005663:Furans; C054351:WF 3681; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase