Macrophages isolated from liver granulomas of murine Schistosoma mansoni synthesize predominantly TxA2 during the acute and chronic phases of infection.
Macrophages isolated from liver granulomas of mice infected with Schistosoma mansoni for 8 or 20 wk synthesize predominantly thromboxane A2 with smaller amounts of the PGE2 and PGI2. There is no physiologic production of leukotrienes, as determined by RIA and HPLC. Thromboxane A2 is the predominant arachidonic acid metabolite whether the cells are stimulated by a phagocytic stimuli such as zymosan or the exogenous substrates arachidonic acid and PGH2. These data indicate that the predominant arachidonate enzymatic activity in these cells is thromboxane synthase.
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D000208:Acute Disease; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D002908:Chronic Disease; D006099:Granuloma / Q000503:physiopathology; D006893:Hydroxyeicosatetraenoic Acids / Q000378:metabolism; D008107:Liver Diseases / Q000503:physiopathology; D008262:Macrophage Activation; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D011450:Prostaglandin Endoperoxides, Synthetic / Q000378:metabolism; D044262:Prostaglandin H2; D011463:Prostaglandins H / Q000378:metabolism; D013189:SRS-A / Q000096:biosynthesis; D012555:Schistosomiasis mansoni / Q000503:physiopathology*; D013928:Thromboxane A2 / Q000096:biosynthesis*; D013930:Thromboxane-A Synthase / Q000378:metabolism
D001095:Arachidonic Acids; D006893:Hydroxyeicosatetraenoic Acids; D011450:Prostaglandin Endoperoxides, Synthetic; D011463:Prostaglandins H; D013189:SRS-A; D016718:Arachidonic Acid; D044262:Prostaglandin H2; D013928:Thromboxane A2; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D013930:Thromboxane-A Synthase