The relative bioavailability of levonorgestrel and ethinylestradiol when administered in tablet and capsule form.
The relative bioavailability of levonorgestrel (LNG) and ethinylestradiol (EE2) administered as a conventional tablet (150/30) or capsule has been assessed in a randomized two-period crossover study in 9 healthy volunteer women. Serum concentrations were monitored for 24h post-dosing. There was no significant difference in any of the pharmacokinetic parameters determined for either steroid. Hence the relative bioavailability is similar after tablet and capsule formulations.
D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D002214:Capsules; D002986:Clinical Trials as Topic; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004997:Ethinyl Estradiol / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D016912:Levonorgestrel; D009644:Norgestrel / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011897:Random Allocation; D013607:Tablets
D002214:Capsules; D003277:Contraceptives, Oral, Combined; D013607:Tablets; D009644:Norgestrel; D004997:Ethinyl Estradiol; D016912:Levonorgestrel