title: Cerebral blood flow and metabolism during controlled hypotension with sodium-nitroprusside and general anaesthesia for total hip replacement a.m. Charnley.
abstract: Cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) were studied during hypotension induced with sodium nitroprusside (SNP) in 10 patients undergoing total hip replacement a.m. Charnley. Cerebral blood flow was measured using an injection of xenon-133 into an arm vein. The decay curve was detected by five scintillation counters placed over each hemisphere and analysed with the Novo 10a cerebrograph. Blood samples were drawn from the radial artery and the jugular venous bulb to calculate the CMRO2. In the group as a whole, there were significant decreases in mean arterial pressure and in cerebrovascular resistance. There were no significant changes, in either CBF or CMRO2 in the group as a whole, but there were substantial individual differences. In conclusion, the use of SNP-induced hypotension for extracranial surgery should be used only in patients monitored closely.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D005292:Ferricyanides; D006339:Heart Rate / Q000187:drug effects; D006622:Hip Prosthesis; D006801:Humans; D007023:Hypotension, Controlled; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside; D011229:Preanesthetic Medication; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D005292:Ferricyanides; D002245:Carbon Dioxide; D009599:Nitroprusside