Human aflatoxin B1 metabolism: an investigation of the importance of aflatoxin Q1 as a metabolite of hepatic post-mitochondrial fraction.
The metabolism of aflatoxin B1 by the post-mitochondrial fraction of human autopsy or biopsy liver and monkey necropsy liver was investigated. Aflatoxin Q1, a hydroxy metabolite of B1, was produced by 18 of 22 human liver samples and by 5 of 7 species of non-human primates investigated. Human specimens from both sexes, ages 20-80 years, with a variety of hepatic histological and historical influences produced this metabolite. Aflatoxin Q1 was of variable quantitative importance. Yields seldom exceeded 10% of initial B1. However, based upon its persistent formation in vitro, these studies identify the need to clarify the role of Q1 in aflatoxin epidemiology.
D000328:Adult; D016604:Aflatoxin B1; D000348:Aflatoxins / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011323:Primates / Q000378:metabolism; D013045:Species Specificity; D013347:Subcellular Fractions / Q000378:metabolism
D000348:Aflatoxins; C033759:aflatoxin Q1; D016604:Aflatoxin B1