What energy level is required to avoid nutrient depletion after surgery in oropharyngeal cancer?
The rate of energy expenditure was repeatedly measured by indirect calorimetry both in the basal state (BMR) and in the resting fed state (RMR) in 8 middle-aged male patients operated for oropharyngeal cancer. In the postsurgical phase, two sequential energy levels were administered by nasogastric tube: (1) a 'maintenance' level (days 3-5) at 1.4 X measured presurgery BMR; (2) a 'supramaintenance' level (days 6-9) at 1.7 X measured BMR on day 6. Before surgery the patients had a BMR averaging (23.7 +/- 1.0 kcal/kg.day). After surgery BMR increased to 27.6 +/- 2.7 kcal/kg.day (day 6), then it decreased to 24.4 +/- 1.4 kcal/kg.day (day 10). The difference between RMR and BMR yielded a nutrient-induced thermogenesis averaging 5 +/- 1 and 8.5 +/- 2% (p less than 0.05) on levels 1 and 2, respectively. It is concluded that an energy level corresponding to 1.4 X presurgery BMR is sufficient to maintain energy and substrate equilibrium in nondepleted patients, whereas 1.7 X BMR induces positive protein and fat balances concomitant to a decrease efficiency of energy utilization.
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D002153:Calorimetry, Indirect; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004734:Energy Metabolism; D004750:Enteral Nutrition; D006801:Humans; D008297:Male; D008875:Middle Aged; D009748:Nutrition Disorders / Q000517:prevention & control*; D009959:Oropharyngeal Neoplasms / Q000378:metabolism* / Q000601:surgery / Q000628:therapy; D010610:Pharyngeal Neoplasms / Q000378:metabolism*; D011182:Postoperative Care; D012709:Serum Albumin / Q000378:metabolism
D001798:Blood Proteins; D012709:Serum Albumin; D002784:Cholesterol