title: Sodium aurothiomalate does not block interleukin 1 production in rabbits.
abstract: Gold salts may attenuate inflammatory processes by inhibiting interleukin 1 production. It is shown that sodium aurothiomalate does not act as an antipyretic after intravenous injection of two pyrogens into rabbits. Consequently, it cannot suppress interleukin 1 production, a conclusion confirmed by an in vitro lymphocyte activating factor assay. Chronic sodium aurothiomalate treatment, however, did depress the blood leucocyte count significantly.
mesh_terms: D000818:Animals; D005260:Female; D005334:Fever / Q000188:drug therapy*; D006052:Gold Sodium Thiomalate / Q000494:pharmacology* / Q000627:therapeutic use; D007375:Interleukin-1 / Q000096:biosynthesis*; D008297:Male; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits
chemical_list: D007375:Interleukin-1; D006052:Gold Sodium Thiomalate