Effect of nigrostriatal dopamine depletion on the post-training, memory-improving action of amphetamine.
Systemic, post-training injections of d-amphetamine improve memory in a variety of learning situations. Evidence from self-stimulation and intra-striatal injection studies suggests that this effect may be a result of the amphetamine-promoted release of endogenous dopamine from nigro-striatal neurons. In the present study this hypothesis was supported by the demonstration that destruction of these neurons with intra-nigral injections of 6-hydroxydopamine eliminate the memory-improving effect of systemic, post-training injections of amphetamine.
D000818:Animals; D002421:Caudate Nucleus / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology; D008029:Lighting; D008297:Male; D008568:Memory / Q000187:drug effects*; D009412:Nerve Fibers / Q000187:drug effects*; D016627:Oxidopamine; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects
D006892:Hydroxydopamines; D016627:Oxidopamine; D003913:Dextroamphetamine; D004298:Dopamine