Colocalization of GHRF and NPY immunoreactivities in neurons of the infundibular area of the human brain.
The distributions of somatocrinin (GHRF) and neuropeptide Y (NPY) immunoreactivities were compared in the infundibular area of the human hypothalamus. About 40% of the arcuate GHRF-stained perikarya were found to costain for NPY, while in the peripheral neurovascular zone of the median eminence the two stainings appeared dissociated. Therefore, it is concluded that a wide population of hypothalamic neurons producing a GHRF-related peptide does not project to the pituitary portal plexus and is thus not involved in the direct neurohemal control of the pituitary somatotropic secretion.
D000328:Adult; D000368:Aged; D001111:Arcuate Nucleus of Hypothalamus / Q000737:chemistry*; D001923:Brain Chemistry; D005260:Female; D013007:Growth Hormone-Releasing Hormone / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000737:chemistry*; D009478:Neuropeptide Y / Q000032:analysis*
D009478:Neuropeptide Y; D013007:Growth Hormone-Releasing Hormone