title: Modification by alfentanil of the haemodynamic response to tracheal intubation in elderly patients. A dose-response study.
abstract: Fifty-five elderly patients undergoing elective ophthalmological surgery were randomly allocated to four groups. Following the induction of anaesthesia with thiopentone (given over 2 min) and the administration of atracurium 0.6 mg kg-1, patients received alfentanil 400, 600, 800 or 1000 micrograms. Intubation of the trachea was performed 90 s later. Heart rate was monitored continuously and systolic arterial pressure was measured at 1-min intervals for 3 min before induction, and both variables were monitored until 10 min had elapsed after tracheal intubation. In each of the groups there was a significant decrease in systolic arterial pressure and a significant increase in heart rate on induction of anaesthesia. In those patients who received either 400 or 600 micrograms of alfentanil, arterial pressure increased immediately after tracheal intubation, whereas in those receiving alfentanil 800 or 1000 micrograms, arterial pressure decreased immediately after tracheal intubation, and when measured 10 min after intubation. It is suggested that alfentanil 600 micrograms (10 micrograms kg-1) constitutes the optimal dose with which to obtund the haemodynamic response to tracheal intubation in elderly patients, and to minimize cardiovascular depression after tracheal intubation.
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage / Q000494:pharmacology*; D000368:Aged; D015760:Alfentanil; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005283:Fentanyl / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007442:Intubation, Intratracheal; D011446:Prospective Studies
chemical_list: D000759:Adjuvants, Anesthesia; D015760:Alfentanil; D005283:Fentanyl