title: Chronobiology of lithium--studies on healthy, middle-aged women.
abstract: 3 women aged 37, 44 and 53 years were examined in a long term study (4-5 months) with and without lithium carbonate medication. The subjective condition and complaints of the subjects were recorded. The body temperature was measured each night with a rectal probe and the data analysed using TIMESDIA-program. During the lithium medication, deterioration in the subjects well-being, and somatic disturbances can occur. At the same time variations in the circadian course of the body temperature were demonstrated. In addition to the 24-hour period, longer and shorter periods appear. Based on a chronobiological model a possible dissociation of the oscillator controlling body temperature is suggested.
mesh_terms: D000328:Adult; D001831:Body Temperature / Q000187:drug effects*; D002909:Chronobiology Phenomena; D005260:Female; D006801:Humans; D008094:Lithium / Q000009:adverse effects / Q000494:pharmacology*; D016651:Lithium Carbonate; D008875:Middle Aged; D008954:Models, Biological
chemical_list: D016651:Lithium Carbonate; D008094:Lithium