[Effect of glucuronic acid on the carcinogenic action of urethane, dibutylnitrosamine and 7,12-dimethyl[A]anthracene].
C57W and SHR mice were given intraperitoneal injections of 100 or 300 mg/kg body weight glucuronic acid (in isotonic NaCl solution) 15-30 minutes prior to treatment with urethan, dibutylnitrosamine or 7,12-dimethyl-1,2-benzanthracene. This resulted in a lower carcinogenic effect on the lung and the incidence of lung adenoma was half that registered in the animals who had received a carcinogen only.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors; D000818:Animals; D002273:Carcinogens / Q000037:antagonists & inhibitors*; D005965:Glucuronates / Q000627:therapeutic use*; D020723:Glucuronic Acid; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000517:prevention & control; D051379:Mice; D009602:Nitrosamines / Q000037:antagonists & inhibitors; D014520:Urethane / Q000037:antagonists & inhibitors
D002273:Carcinogens; D005965:Glucuronates; D009602:Nitrosamines; D014520:Urethane; D015127:9,10-Dimethyl-1,2-benzanthracene; D020723:Glucuronic Acid; C012279:dibutylnitrosamine
Vliianie gliukuronovoĭ kisloty na kantserogennoe deĭstvie uretana, dibutilnitrozamina i 7,12-dimetilbenz[A]antratsena.