Recurrent seizures following mucosal application of TAC.
A 5-year-old 20-kg boy developed grand mal seizures following application of 2 mL of tetracaine-adrenalin-cocaine to an oral mucosa laceration. Diazepam 6 mg IV followed by 195 mg phenobarbital was required to terminate the seizures. The patient was transferred to a pediatric intensive care unit for further evaluation and treatment. A toxicology screen obtained after transfer was positive only for diazepam and phenobarbital. The child remained lethargic for several hours but otherwise had a normal neurological examination. Brain computed tomography was normal. Anticonvulsant medication was discontinued prior to discharge and the child had no subsequent seizures.
D000278:Administration, Buccal; D000779:Anesthetics, Local / Q000009:adverse effects*; D002675:Child, Preschool; D003042:Cocaine / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced* / Q000188:drug therapy; D004837:Epinephrine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use; D013748:Tetracaine / Q000009:adverse effects*
D000779:Anesthetics, Local; D004338:Drug Combinations; D013748:Tetracaine; C034627:TEC solution; D003042:Cocaine; D004837:Epinephrine; D010634:Phenobarbital