[Activation of phagocytosis by preparations of human alpha and gamma interferons].
Preparations of human alpha- and gamma-interferon differing by the method of production and purification had different capacity of activating phagocytosis of blood polymorphonuclear leukocytes from patients with dermatoses. Native preparations of alpha- and gamma-interferon had the highest phagocytosis-activating potency. A high level of this activity was also demonstrated with human leukocyte interferon II for injections purified by highly specific methods. A concentrated preparation of human leukocyte interferon for injections with a specific activity above 1 million IU/1 mg of protein and recombinant alpha 2-interferon (reaferon) exhibited minimal phagocytosis activating effect.
D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D007371:Interferon-gamma / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects*; D011994:Recombinant Proteins / Q000494:pharmacology; D013268:Stimulation, Chemical
D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D007371:Interferon-gamma
Aktivatsiia fagotsitoza preparatami chelovecheskogo al'fa- i gamma-interferona.