title: Effects of DCPD/APF application and prolonged exposure to fluoride on caries-like lesion formation in vitro.
abstract: The ability of a topical fluoride regimen consisting of a 4-min application of a saturated dicalcium phosphate dihydrate (DCPD) solution followed by a 4-min application of 1.23% acidulated phosphate fluoride (APF) to inhibit caries-like lesion formation in sound enamel was compared to that of a 4-min application of APF. Following the applications, specimens were washed for 24 h in an inorganic wash solution or for 28 days in a wash solution containing 1 ppm fluoride. The mean overall lesion depth for specimens treated with APF and washed for 28 days was significantly greater than that for the group treated with DCPD/APF and washed for 28 days, and for the group treated with APF and washed for 24 h (p less than 0.05). For those specimens washed for 24 h, the mean width of the surface zone was greater (p less than 0.05) for the DCPD/APF group compared to the APF group.
mesh_terms: D000149:Acidulated Phosphate Fluoride / Q000494:pharmacology / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000494:pharmacology / Q000627:therapeutic use*; D003731:Dental Caries / Q000517:prevention & control*; D003743:Dental Enamel / Q000187:drug effects*; D003747:Dental Enamel Solubility / Q000187:drug effects; D005460:Fluorides, Topical / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D012969:Sodium Fluoride / Q000031:analogs & derivatives*
chemical_list: D002130:Calcium Phosphates; D005460:Fluorides, Topical; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D000149:Acidulated Phosphate Fluoride; C485838:calcium phosphate, monobasic, anhydrous; D012969:Sodium Fluoride; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous