title: Genotoxicity of Rogor studied in the sex-linked recessive lethal test and wing, eye and female germ-line mosaic assays in Drosophila melanogaster.
abstract: The genotoxic potential of Rogor (dimethoate), an anticholinesterase organophosphate insecticide, has been studied in the sex-linked recessive lethal test and the wing, eye and female germ-line mosaic assays in Drosophila melanogaster. Larvae of different instars carrying suitable recessive genetic markers on their first and third chromosomes were exposed to the LD50 or half of this dose for the entire larval life. The Basc technique was followed for the detection of the induction of sex-linked recessive lethals. The wings and eyes of the adult flies and the eggs laid by the heterozygous females were checked for the induction of mosaicism. It is concluded that Rogor induces sex-linked recessive lethals in immature male germ cells and is recombinogenic and/or mutagenic in both the somatic and the germ-line cells of Drosophila.
mesh_terms: D000818:Animals; D004117:Dimethoate / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics; D005123:Eye; D005804:Genes, Lethal; D005808:Genes, Recessive; D007814:Larva / Q000187:drug effects; D009030:Mosaicism; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D014921:Wings, Animal
chemical_list: D004117:Dimethoate