[Effectiveness of the combined therapy of pulmonary mycobacterial infections depending on the species classification of the causative agent].
The purpose of the study was to define the effect of specific tubercle bacillus on a course of pulmonary tuberculosis and the role of atypical mycobacteria in the development of "nontuberculous mycobacterioses". A total of 1896 mycobacterial cultures isolated from 1285 patients were identified. Mycobacterial cultures from 86 patients were identified as M. bovis; mycobacteria of the "atypical" group from 12 patients were agents of nontuberculous mycobacterioses. Cultures in 7 patients were identified as M. avium. in 2 patients as M. xenopi, and in 3 as M. fortuitum. Therapeutic results showed an unfavorable course of tuberculosis caused by M. bovis (disintegration cavity closing in 40.7% only and bacillus elimination in 52.3% of the cases). A tendency to a torpid course and progression of nontuberculous mycobacterioses was noted. The best results were obtained with the use of a rapid method of i.v. injection of isoniazid and with the use of rifampicin.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009161:Mycobacterium / Q000145:classification*; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy / Q000382:microbiology; D009163:Mycobacterium bovis / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification; D009170:Nontuberculous Mycobacteria / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology
D000995:Antitubercular Agents
Effektivnost' kompleksnoĭ terapii mikobakteriozov legkikh v zavisimosti ot vidovoĭ prinadlezhnosti vozbuditelia.