C-reactive protein-immunoglobulin complexes in two patients with macroglobulinemia.
Two patients with macroglobulinemia, one with a monoclonal IgA and the other with a monoclonal IgM, are described. In connection with cytostatic treatment and infection both patients got very high CRP-concentrations as measured by laser nephelometry. These seemed to be caused by C-reactive protein immunoglobulin complex formation as determined by immunofixation.
D000911:Antibodies, Monoclonal / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007158:Immunologic Techniques; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D008258:Waldenstrom Macroglobulinemia / Q000097:blood / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D002097:C-Reactive Protein