[Studies of clinical efficacy of ofloxacin against male urethritis caused by Chlamydia trachomatis].
A multi-institutional clinical study was performed on the efficacy of Ofloxacin against chlamydial urethritis in males between January and June, 1987. Chlamydia trachomatis was detected in 68 (38.2%) among 178 patients with male urethritis by the antichlamydial FITC monoclonal antibody technic (Micro Trak). Neisseria gonorrhoeae was isolated in 51 patients (28.7%) and C. trachomatis was also detected in 8 of them. Ofloxacin was administered at a dosage of 600 mg divided into 3 doses for 14 days. One hundred and forty-eight patients including 53 with chlamydial urethritis were evaluable for clinical efficacy. C. trachomatis did not disappear in 6 patients (13.6%) and 2 (8.3%) after the therapy for 7 and 14 days, respectively. After 7 days of therapy, both the pathogen and urethral excretions had disappeared from 79.6% of the patients with chlamydial urethritis, and from 84.8% of those with gonorrheal urethritis; and after 14 days of therapy they had disappeared from 94.1 and 90.9% of the patients, respectively.
D000328:Adult; D000368:Aged; D002690:Chlamydia Infections / Q000188:drug therapy* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000187:drug effects / Q000302:isolation & purification; D004341:Drug Evaluation; D006069:Gonorrhea / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000302:isolation & purification; D015242:Ofloxacin; D010078:Oxazines / Q000008:administration & dosage / Q000627:therapeutic use*; D014526:Urethritis / Q000188:drug therapy* / Q000382:microbiology
D010078:Oxazines; D015242:Ofloxacin