[Evolution from 1976 to 1986 of bacterial prevalence and sensitivity to urinary antibiotics of bacteria isolated from urine cultures at a city microbiology laboratory].
The evolution of the prevalence of the bacterial strains isolated from UTI cases (bacteriuria greater than or equal to 10(5)/ml has been studied over a 11 year-period from 1976 to 1986, in a clinical practice microbiological laboratory from a rural area. E. coli was the overall most frequently isolated species, followed by P. mirabilis (74.4% and 11.2% respectively), by the Klebsiella-Enterobacter group (4.8%), and staphylococci (represented by coagulase negative staphylococci) (4.9%). The relative frequency of the different species has been relatively stable year after year during the considered period. The evolution of the resistance to 4 antibiotics has been studied species by species and year after year for the Gram negative bacilli: a definite evolution towards resistance has been noted for ampicillin until 1985, followed by a decrease in 1986. The same tendency, although less pronounced, has been noted for cotrimoxazole. The frequency of the resistance to nalidixic acid has slightly increased from 1976 to 1986 (1.9% to 6.5%), as well as to pipemidic acid from (0% to 4%). The quinolones stand in 1987 as a good first line treatment of UTI in community, and especially in rural areas, and the role of the clinical practice microbiological laboratory for the epidemiological surveillance has to be stressed.
D000667:Ampicillin / Q000494:pharmacology*; D000668:Ampicillin Resistance; D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification*; D004338:Drug Combinations / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004754:Enterobacter / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007709:Klebsiella / Q000187:drug effects; D009268:Nalidixic Acid / Q000494:pharmacology; D010876:Pipemidic Acid / Q000494:pharmacology; D011513:Proteus mirabilis / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013420:Sulfamethoxazole / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014556:Urine / Q000382:microbiology*
D000892:Anti-Infective Agents, Urinary; D004338:Drug Combinations; D009268:Nalidixic Acid; D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole; D010876:Pipemidic Acid
Evolution de 1976 à 1986 de la prévalence bactérienne et de la sensibilité aux antibiotiques urinaires des bactéries isolées d'urocultures dans un laboratoire de microbiologie de ville.