Listeria monocytogenes specific T-cell lines and clones.
Evidence is summarized to suggest that both CD4 and CD8 T cells and both helper and cytolytic T cell functions are involved in protective immunity to infection with the intracellular bacterium, Listeria monocytogenes. This suggestion is based on the following findings obtained with T cell lines and clones from L. monocytogenes infected mice: L3T4+ (CD4) T cells produce multiple lymphokines after antigen stimulation in vitro; Lyt2+ (CD8) T cells lyse L. monocytogenes primed macrophages; L3T4+ (CD4) T cells also lyse L. monocytogenes primed macrophages provided the latter express Ia-molecules; Lyt2+ (CD8) T cells secret Interferon-gamma provided that exogenous Interleukin-2 is supplied. Furthermore, both L3T4+ (CD4) and Lyt2+ (CD8) T cell lines can confer a certain degree of adoptive protection upon naive recipient mice.
D000818:Animals; D002460:Cell Line; D002999:Clone Cells; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000096:biosynthesis; D008089:Listeria monocytogenes / Q000276:immunology*; D008088:Listeriosis / Q000276:immunology*; D008222:Lymphokines / Q000096:biosynthesis; D051379:Mice; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000378:metabolism
D008222:Lymphokines; D007371:Interferon-gamma