Changes of plasma fibronectin concentration and phagocytic activity in immunosuppressed patients during selective decontamination.
Plasma fibronectin and phagocytic activity play important roles in combating infections. The question is discussed, whether both defense systems are also of importance in immunosuppressed patients. Further, the behaviour of plasma fibronectin determined by laser nephelometry, and phagocytic activity determined by chemiluminescence is demonstrated in patients with leukaemia under the conditions of selective decontamination of the intestinal tract. The following results are shown: Plasma fibronectin concentration decreases 10 to 14 days before onset of the first clinical signs of an infection. Plasma fibronectin level changes appear earlier than that of C-reactive protein (Crp). Therefore, it is suitable as a parameter for assessment of the course of an infection. Decreased plasma fibronectin levels occurring over longer periods have to be regarded as unfavourable prognostic criterion. The phagocytic activity of immunosuppressed patients selectively decontaminated is significantly below that of healthy adults. A clear assignment of phagocytic activity to the clinical picture, the number of granulocytes and plasma fibronectin level is not possible at present. Additional studies are necessary. Both plasma fibronectin level and phagocytic activity do not appear to be influenced by selective decontamination of the intestinal tract.
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000032:analysis; D004198:Disease Susceptibility; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D017053:Infection Control; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D010587:Phagocytosis / Q000187:drug effects
D000900:Anti-Bacterial Agents; D005353:Fibronectins; D002097:C-Reactive Protein