Fetal heart block, anti-SSA and anti-SSB antibodies. Association with intra-uterine growth retardation, fetal death and lupus anticoagulant.
A case of complete fetal heart block associated with intra-uterine growth retardation, SSA- and SSB-antibodies is presented. The fetus died in utero. Autopsy revealed damage to the fetal cardiac conducting system together with severe placental fibrosis and recent infarctions. These findings and a slightly prolonged activated partial thromboplastin time indicated also the presence of the lupus anticoagulant.
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology*; D002114:Calcinosis / Q000150:complications / Q000276:immunology; D005260:Female; D005313:Fetal Death / Q000209:etiology / Q000276:immunology*; D005315:Fetal Diseases / Q000276:immunology; D005317:Fetal Growth Retardation / Q000150:complications / Q000276:immunology*; D006327:Heart Block / Q000150:complications / Q000276:immunology*; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D011247:Pregnancy
D000974:Antibodies, Antinuclear; D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor; C035356:SS-A antibodies; C035357:SS-B antibodies