[Therapeutic results with tamoxifen in oligospermia. II. Hormonal analysis and semen parameters].
During a five months lasting treatment with tamoxifen (2 X 10 resp. 2 X 20 mg daily) a significant increase of testosterone, LH, FSH, estradiol, free testosterone and SHBG was found. The prolactin levels diminished. In semen analysis the values of pH and fructose decreased within the normal range. The sperm density increased significantly, but we could not ascertain whether a dosage of 2 X 20 mg/die will provide better therapeutic results. Furthermore the hormonal and seminal investigations described in this paper did not allow to predict those patients who would be good responders on tamoxifen therapy. Tamoxifen seems to be effective in normo-, but also in hypo- and hypergonadotropic patients.
D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D005632:Fructose / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009845:Oligospermia / Q000188:drug therapy / Q000378:metabolism*; D011388:Prolactin / Q000097:blood; D012661:Semen / Q000378:metabolism*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013076:Sperm Count; D013629:Tamoxifen / Q000627:therapeutic use*; D013739:Testosterone / Q000097:blood
D012739:Gonadal Steroid Hormones; D012738:Sex Hormone-Binding Globulin; D013629:Tamoxifen; D005632:Fructose; D013739:Testosterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Ergebnisse der Tamoxifen-Therapie bei Oligozoospermie. Teil II: Hormonanalysen und Ejakulatbefunde.