title: The 43 kDa inhibitor of human skin and other epithelia.
abstract: We have used immunohistochemical and quantitative immunochemical techniques to study the tissue distribution of the 43 kDa papain inhibiting protein, originally isolated from psoriatic scale. High amounts of the inhibitor were found in the epidermis only in several skin diseases where the epidermal cell proliferation was increased (psoriasis, various eczemas). The inhibitor was also found in the basal cells of the bronchial epithelium and in the squamous epithelia of mouth and oesophagus, and the Hassal's corpuscles of the thymus. Sera of patients suffering from several skin diseases did not contain the inhibitor, but antibodies against it were found in the sera of two patients suffering from leg ulceration. The inhibitor was immunologically unrelated to filaggrin, involucrin, or keratins.
mesh_terms: D004591:Electrophoresis, Polyacrylamide Gel; D004848:Epithelium / Q000032:analysis*; D000091344:Filaggrin Proteins; D006801:Humans; D005779:Immunodiffusion; D007124:Immunoenzyme Techniques; D008970:Molecular Weight; D010206:Papain / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000302:isolation & purification*; D012867:Skin / Q000032:analysis*
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D011480:Protease Inhibitors; D010206:Papain