Comparative morphological study of age related mitochondrial changes of the lymphocytes and skeletal muscle cells.
The age dependent electron microscopic changes of the mitochondria in a mitotic cell (lymphocyte) were compared with those of a postmitotic cell (skeletal muscle cell) in humans and in CBA/Ca mice. Two types of age related changes could be observed in the mitochondria of lymphocytes and skeletal muscle cells: (i) degenerative changes; (ii) giant mitochondria. The frequency of the mitochondrial changes increased with age and were more frequent in the skeletal muscle cells than in the lymphocytes.
D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology*; D000818:Animals; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008854:Microscopy, Electron; D008875:Middle Aged; D008928:Mitochondria / Q000473:pathology* / Q000648:ultrastructure; D008931:Mitochondria, Muscle / Q000473:pathology* / Q000648:ultrastructure