Susceptibility of Schistosoma mansoni prevalent in Saudi Arabia to oxamniquine in experimentally infected mice.
The therapeutic efficiency of oxamniquine against the local strain of Schistosoma mansoni was investigated in experimentally infected mice. The drug was administered orally using a human-equivalent dose of 20 mg kg-1 day-1 for 3 consecutive days (total dose of 60 mg kg-1). Oxamniquine proved to be very effective as indicated by hepatic shift, oogram changes, complete elimination of adult worms and eradication of faecal eggs.
D000284:Administration, Oral; D000818:Animals; D005243:Feces / Q000469:parasitology; D005260:Female; D008099:Liver / Q000469:parasitology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009600:Nitroquinolines / Q000627:therapeutic use*; D010073:Oxamniquine / Q000008:administration & dosage / Q000627:therapeutic use*; D010270:Parasite Egg Count; D012529:Saudi Arabia; D012550:Schistosoma mansoni / Q000187:drug effects; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000469:parasitology
D009600:Nitroquinolines; D010073:Oxamniquine