Polymerized serum albumin beads possessing slow release properties for use in vaccines.
Experimental vaccines have been made by co-polymerizing virus particles and virus subunits into rabbit serum albumin beads. When injected into rabbits these model vaccines induced specific humoral antibody production and mimicked vaccines prepared using Freund's incomplete adjuvant. No adverse reactions occurred in experimental rabbits and no antibodies reacting with polymerized rabbit serum albumin beads were found. Immunostimulation is attributed to a slow release of antigen coinciding with the gradual breakdown of bead structure.
D000818:Animals; D000833:Animals, Suckling / Q000276:immunology; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005976:Glutaral / Q000276:immunology; D007114:Immunization; D007074:Immunoglobulin G / Q000032:analysis; D051379:Mice; D008863:Microspheres; D011108:Polymers; D011817:Rabbits; D011863:Radioimmunoassay; D012709:Serum Albumin / Q000032:analysis / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D007074:Immunoglobulin G; D011108:Polymers; D012709:Serum Albumin; D014764:Viral Proteins; D014765:Viral Vaccines; D005976:Glutaral