Antiepileptic drugs reduce serum uric acid.
Uric acid examination in 554 epileptic out-patients under long-term anticonvulsant medication revealed significantly lower serum concentrations compared to a group of normal controls. In patients taking enzyme-inducing drugs, uric acid levels were found to be lower than in those under valproate sodium. In addition, uric acid concentrations showed a negative correlation with duration of therapy in epileptic males. At this time, we can only speculate on the mechanism involved in the reduction of uric acid by enzyme-inducing anticonvulsants as well as on the possible implication of this finding in the treatment of hyperuricemia.
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000627:therapeutic use*; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood*; D014635:Valproic Acid / Q000627:therapeutic use*
D000927:Anticonvulsants; D014527:Uric Acid; D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin