Immunoblastic peripheral T-cell lymphoma confined to bone marrow in an infant presenting with aspergillosis.
A 16-month-old female infant presenting with pancytopenia and fever was found to have pulmonary aspergillosis and large-cell immunoblastic non-Hodgkin's lymphoma of peripheral post-thymic origin isolated to bone marrow. Extensive noninvasive evaluations failed to demonstrate the disease in other extramedullary sites. The malignant cells were large and polymorphous; lacked terminal transferase; expressed surface CD-2, CD-3, CD-8, and HLA-DR antigens, and showed rearrangements of the T-cell-receptor beta-chain gene. To our knowledge, this type of lymphoma in an infant has not been reported before. Furthermore, aspergillosis is a rare presenting feature in patients with lymphoproliferative disease. In our case, it may reflect an underlying immune deficiency associated with the transformation and proliferation of a suppressor T cell.
D001228:Aspergillosis / Q000276:immunology*; D001231:Aspergillus flavus; D001855:Bone Marrow Diseases / Q000235:genetics / Q000473:pathology*; D004273:DNA, Neoplasm; D005260:Female; D006801:Humans; D007223:Infant; D008172:Lung Diseases, Fungal / Q000276:immunology*; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000473:pathology*; D009693:Nucleic Acid Hybridization; D009894:Opportunistic Infections; D011003:Ploidies; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes
D004273:DNA, Neoplasm; D011948:Receptors, Antigen, T-Cell