DNA damage in urinary bladder epithelium of male F344 rats treated with 2-phenyl-1,4-benzoquinone, one of the non-conjugated urinary metabolites of sodium o-phenylphenate.
DNA damage in the urinary bladder epithelium of male F344 rat was tested by alkaline elution assay after an intravesical injection of o-phenylphenol (OPP) or its non-conjugated urinary metabolites. DNA damage, as represented by an increase of the elution rate constant, was induced by the injection of 2-phenyl-1,4-benzoquinone (PBQ) at the concentration of 0.05-0.1%, but was not observed after the injection of either OPP or 2,5-dihydroxyphenyl at 0.05%. Histopathologically, a single intravesical injection of 0.05% or 0.1% PBQ was shown to induce epithelial hyperplasia of the bladder epithelium on day 5 after the treatment.
D000818:Animals; D016227:Benzoquinones; D001713:Biphenyl Compounds / Q000378:metabolism / Q000633:toxicity; D004247:DNA / Q000187:drug effects*; D004249:DNA Damage; D004848:Epithelium / Q000187:drug effects; D006965:Hyperplasia / Q000139:chemically induced; D008297:Male; D011809:Quinones / Q000633:toxicity*; D051381:Rats; D001743:Urinary Bladder / Q000187:drug effects*
D016227:Benzoquinones; D001713:Biphenyl Compounds; D011809:Quinones; C029322:phenylbenzoquinone; D004247:DNA; C004369:2-phenylphenol