Promethazine, scopolamine and cinnarizine: comparative time course of psychological performance effects.
Single oral doses of promethazine (12.5 mg, 25 mg), scopolamine (0.6 mg), and cinnarizine (30 mg), were compared in a double-blind, placebo controlled trial. Twelve normal volunteers undertook a battery of psychological performance tests and a feeling state questionnaire, before drug administration, and at 2-h intervals after. Promethazine and cinnarizine significantly impaired psychomotor performance, information processing and feelings of alertness. With promethazine these reductions were maximal 3-4 h post-drug, with performance returning near to baseline 8-9 h post-drug. With cinnarizine these impairments were maximal 5-6 h post-drug, and performance remained depressed 8-9 h post-drug. Scopolamine significantly reduced feelings of alertness, and memory task performance; the overall performance effects were most evident 1-4 h post-drug.
D000293:Adolescent; D000328:Adult; D002936:Cinnarizine / Q000009:adverse effects / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects; D004644:Emotions / Q000187:drug effects; D005425:Flicker Fusion / Q000187:drug effects; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D011398:Promethazine / Q000009:adverse effects / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects*; D012601:Scopolamine / Q000009:adverse effects / Q000494:pharmacology*
D002936:Cinnarizine; D012601:Scopolamine; D011398:Promethazine