In vitro activity of temafloxacin, a new difluoro quinolone antimicrobial agent.
Temafloxacin, a new difluoro quinolone, inhibited the majority of Enterobacteriaceae at less than or equal to 1 microgram/ml. It was 4-8-fold less active than ciprofloxacin and 2-fold less active than ofloxacin. Cefotaxime and imipenem-resistant isolates such as Enterobacter cloacae, Citrobacter freundii, Pseudomonas aeruginosa, and Acinetobacter spp. were inhibited. Temafloxacin inhibited Neisseria, Branhamella, and Haemophilus species at less than 0.25 microgram/ml. Methicillin-susceptible and methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis and Clostridium spp. were inhibited at concentrations less or equal to that of ciprofloxacin and ofloxacin.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002439:Cefotaxime / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D002939:Ciprofloxacin / Q000494:pharmacology; D003470:Culture Media; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects; D024841:Fluoroquinolones; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D015378:Imipenem; D008274:Magnesium / Q000494:pharmacology; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology; D011549:Pseudomonas / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology*; D015363:Quinolones; D013845:Thienamycins / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D003470:Culture Media; D024841:Fluoroquinolones; D010078:Oxazines; D011804:Quinolines; D015363:Quinolones; D013845:Thienamycins; C054745:temafloxacin; D002939:Ciprofloxacin; D015378:Imipenem; D015242:Ofloxacin; D008274:Magnesium; D002439:Cefotaxime