Alterations in outer membrane proteins of Pseudomonas aeruginosa associated with selective resistance to quinolones.
Electrophoresis of outer membrane proteins in three ciprofloxacin-resistant strains of Pseudomonas aeruginosa isolated during therapy and their in vitro revertants indicated that diminution or loss of a 31- to 32-kilodalton outer membrane protein correlated with resistance in two of the three isolates. Resistance was unstable and caused no cross-resistance with other antibiotics.
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis*; D002462:Cell Membrane / Q000032:analysis; D002511:Cephalosporins / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D009643:Norfloxacin / Q000494:pharmacology*; D010406:Penicillins / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000032:analysis* / Q000187:drug effects / Q000648:ultrastructure
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D002511:Cephalosporins; D010406:Penicillins; D002939:Ciprofloxacin; D009643:Norfloxacin