An aberrant subclass pattern of HIV-specific immunoglobulin G in sera from haemophiliacs.
The immunoglobulin (lg) G subclass response against HIV was investigated in sera from 13 haemophiliacs and 21 non-haemophiliacs. Monoclonal antibodies specific for the human lgG subclasses were used in an enzyme immunoblot assay, which was evaluated densitometrically. Seven of the haemophiliacs had detectable lgG4 antibodies to p24, a pattern which was found in only one of the sera from the non-haemophiliacs (P = 0.0022). This observation could partly be explained by a longer duration of the HIV infection in the subjects with lgG4 antibodies to HIV. No connection was found between frequency of administration of blood products and presence of HIV-specific lgG4.
D000911:Antibodies, Monoclonal; D005260:Female; D006678:HIV / Q000276:immunology; D015483:HIV Antibodies / Q000032:analysis*; D006467:Hemophilia A / Q000276:immunology*; D002836:Hemophilia B / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000145:classification*; D007132:Immunoglobulin Isotypes / Q000032:analysis*; D008206:Lymphatic Diseases / Q000276:immunology; D008297:Male
D000911:Antibodies, Monoclonal; D015483:HIV Antibodies; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes