title: Somatic recombination and mutation assays in Drosophila: a comparison of the response of two different strains to four mutagens.
abstract: To compare the responses of 2 different strains used in somatic mutation assays of Drosophila, 4 chemical mutagens - methyl methanesulfonate, ethyl nitrosourea, adriamycin and daunomycin - were tested under standardized conditions in parallel experiments. Positive results were obtained for all 4 chemicals in both strains but there was a marked difference in the yield of somatic mutations between the 2 strains.
mesh_terms: D000818:Animals; D003630:Daunorubicin / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics*; D005038:Ethylnitrosourea / Q000494:pharmacology; D005127:Eye Color; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D009030:Mosaicism; D009152:Mutagenicity Tests / Q000592:standards*; D009153:Mutagens / Q000494:pharmacology*; D011995:Recombination, Genetic / Q000187:drug effects*; D013045:Species Specificity
chemical_list: D009153:Mutagens; D004317:Doxorubicin; D008741:Methyl Methanesulfonate; D005038:Ethylnitrosourea; D003630:Daunorubicin