The effect of chronic met-enk on various dopamine systems in the rat.
Morphine and enkephalins act preferentially via different receptors, mu and delta, respectively. Chronic administration of morphine or methionine enkephalin results in development of physical dependence. Data from our laboratory suggests that there are some differences in the effect of these two opioids with regards to certain neurochemical systems.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000502:physiology*; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D009021:Morphine Dependence / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*; D013239:Stereotyped Behavior / Q000187:drug effects; D019966:Substance-Related Disorders / Q000503:physiopathology*
D011954:Receptors, Dopamine; D004744:Enkephalin, Methionine; D001058:Apomorphine; D004298:Dopamine