title: [Cell-free Pseudomonas vaccine: its immunochemical characteristics and immunogenicity].
abstract: Two variants of cell-free protein vaccine have been prepared from the mixture of 4 P. aeruginosa strains, serovars 02, 06, 07 and 011, and from a single P. aeruginosa strain, serovar 02. The preparation contains proteins with molecular weight ranging from 20,000 to 100,000 and the admixture of lipopolysaccharide in negligible amounts (not exceeding 0.08% of dry weight). The vaccine produces no signs of toxicosis in laboratory animals. The vaccine effectively protects mice challenged with P. aeruginosa of different O-serotypes and stimulates the formation of specific protective antibodies in rabbits.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D001428:Bacterial Vaccines / Q000276:immunology* / Q000302:isolation & purification / Q000633:toxicity; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003429:Cross Reactions; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D007114:Immunization; D007120:Immunochemistry; D007928:Lethal Dose 50; D051379:Mice; D011552:Pseudomonas Infections / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D011817:Rabbits; D051381:Rats
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines
vernacular_title: Beskletochnaia vaktsina psevdomonas: immunokhimicheskaia kharakteristika i immunogennost'.