[Thrombolytic properties of the heparin-tissue plasminogen activator complex and its effect on the fibrinolytic and coagulating systems of the blood in animals].
A complex heparin-tissue activator of plasminogen maintain its thrombolytic properties due to the presence of the activator. Studies of thrombolytic properties of the complex in vitro and of its effect in vivo on animal blood fibrinolytic and coagulation systems after intravenous administration confirmed this contention. After intravenous administration into animals the complex caused only slight effect on the system of fibrinolysis and inhibited moderately the coagulating activity of blood. This combination of heparin and tissue activator of plasminogen appears to be important in treatment of thromboses.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D005342:Fibrinolysis / Q000187:drug effects*; D005343:Fibrinolytic Agents; D006493:Heparin / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D013552:Swine; D010959:Tissue Plasminogen Activator / Q000494:pharmacology*
D005343:Fibrinolytic Agents; D006493:Heparin; D010959:Tissue Plasminogen Activator
Tromboliticheskie svoĭstva kompleksa geparin-tkanevyĭ aktivator plazminogena i ego vliianie na fibrinoliticheskuiu i svertyvaiushchuiu sistemy krovi zhivotnykh.