title: [Study on the screening of thyroidal dysfunction in adult].
abstract: For the purpose of screening of thyroidal dysfunction in adult, we have collected blood of 15,905 (male 11,559, female 4,346) adult normal workers and school students on filter papers at the time of the annual health examination. Both TSH and total T4 were measured by radioimmunoassay. Either TSH or total T4 or both showed abnormal values in 148 cases. For these subjects, serum TSH, total T4 and T3, free T4, TBG, antimicrosomal and antithyroglobulin antibody were estimated. From these results, diagnosis was made as follows: 6 hyperthyroidism, 12 primary hypothyroidism (including 3 subclinical hypothyroidism who showed elevated TSH and normal free T4 values) and 29 TBG abnormality (increase: 8, decrease or deficiency: 21). The incidence by this study was: hyperthyroidism 0.038% (1/2650), primary hypothyroidism 0.075% (1/1330), TBG increase or deficiency 0.132% (1/760). Sex ratio of thyroidal dysfunction were higher in female than male. In hyperthyroidism, ratio of male to female was 1:2.66, and in hypothyroidism, it was 1:133. Most of these patients were not diagnosed before this screening. The fact that the incidence of hypothyroidism was higher than hyperthyroidism in this population was apparent in this study. TBG abnormality was noted more in male than female. This report is important to show the incidence of thyroidal abnormalities and the necessity of the screening test of thyroid in adult.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000453:epidemiology; D007037:Hypothyroidism / Q000453:epidemiology; D007564:Japan; D008297:Male; D008403:Mass Screening / Q000379:methods*; D012737:Sex Factors; D013959:Thyroid Diseases / Q000453:epidemiology* / Q000378:metabolism; D013960:Thyroid Function Tests; D013975:Thyroxine-Binding Proteins / Q000378:metabolism
chemical_list: D013975:Thyroxine-Binding Proteins