Inhibition of virulent Mycobacterium tuberculosis by murine peritoneal macrophages and human alveolar lavage cells: the effects of lymphokines and recombinant gamma interferon.
Both murine peritoneal macrophages and human alveolar lavage cells inhibited growth of M. tuberculosis in a medium containing 10% foetal calf serum. However, whereas addition of recombinant gamma interferon or crude lymphokine reproducibly activated further strong anti-mycobacterial mechanisms in the murine cells, these stimuli had weak and variable effects on human alveolar cells.
D000818:Animals; D003470:Culture Media; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008222:Lymphokines / Q000494:pharmacology*; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000254:growth & development*; D010529:Peritoneal Cavity / Q000166:cytology; D011650:Pulmonary Alveoli / Q000166:cytology
D003470:Culture Media; D008222:Lymphokines; D007371:Interferon-gamma