title: The role of microtubule polarity in the movement of kinesin and kinetochores.
abstract: Microtubules are important for organizing and directing many types of intracellular motility. Recently progress has been made in the analysis of two types of motility at the molecular level: the movement of axonal vesicles driven by kinesin, and the movement of chromosomes driven by the kinetochore. Both require ATP for movement in vitro. Kinesin-driven movement is unidirectional, towards the microtubule plus end, while movement of the kinetochore is bidirectional. These similarities and differences are discussed and incorporated into a new model for the kinetochore-microtubule interface.
mesh_terms: D000818:Animals; D002503:Centromere / Q000502:physiology* / Q000648:ultrastructure; D002875:Chromosomes / Q000502:physiology*; D016547:Kinesins; D008868:Microtubule Proteins / Q000502:physiology*; D008870:Microtubules / Q000502:physiology* / Q000648:ultrastructure; D008954:Models, Biological; D009068:Movement; D009419:Nerve Tissue Proteins / Q000502:physiology*
chemical_list: D008868:Microtubule Proteins; D009419:Nerve Tissue Proteins; D016547:Kinesins