title: Plasma concentrations of factor VIII after administration of DDAVP to conscious dogs.
abstract: The effect of the vasopressin analogue DDAVP on Factor VIII in plasma has been extensively studied in humans. To examine the effect of new and potentially better analogues a suitable animal model has to be established. In the present study trained Beagle dogs were injected with DDAVP and the time course of the Factor VIII response was monitored by a modification of the chromogenic substrate assay for Factor VIII. In most of the dogs DDAVP caused a biphasic increase of plasma concentrations of Factor VIII with an initial smaller increment within 10 min after the injection followed by a larger secondary rise after approximately 45 min. The average increase in Factor VIII was smaller than found in humans after comparable doses of DDAVP, and a few dogs responded very poorly. Despite these qualitative and quantitative differences it is concluded that trained dogs may serve as a useful model for testing the ability of other analogues than DDAVP to increase Factor VIII.
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D005169:Factor VIII / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D013045:Species Specificity
chemical_list: D005169:Factor VIII; D003894:Deamino Arginine Vasopressin