[Effectiveness of immunizing donors with adsorbed tetanus anatoxin in relation to their genetic markers].
Blood groups, including rhesus grouping, have been determined in 218 donors and HLA of loci A, B, C in 121 donors immunized with adsorbed tetanus toxoid (40 binding units). The presence of HLA Aw 32, B 8; HLA Bw 16, haplotypes A3 Bw 16 and A1, blank antigens of locus C is linked with the production of, respectively, high or low (less than or equal to 16 I.U./ml) antibody titers. The effectiveness of immunization is influenced by agglutinogen B, which is confirmed by its associations (in a complex with HLA Bw 16 or Bw 35) with low immune response.
D000017:ABO Blood-Group System / Q000235:genetics / Q000276:immunology; D000327:Adsorption; D000907:Antibodies, Bacterial / Q000032:analysis; D001782:Blood Donors; D003017:Clostridium tetani / Q000276:immunology; D005819:Genetic Markers; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D007114:Immunization; D012204:Rh-Hr Blood-Group System / Q000235:genetics / Q000276:immunology; D012727:Sex Characteristics; D013745:Tetanus Toxoid / Q000276:immunology*
D000017:ABO Blood-Group System; D000907:Antibodies, Bacterial; D005819:Genetic Markers; D006680:HLA Antigens; D012204:Rh-Hr Blood-Group System; D013745:Tetanus Toxoid
Effektivnost' immunizatsii donorov adsorbirovannym stolbniachnym anatoksinom v zavisimosti ot nekotorykh geneticheskikh markerov.