Assessment of cytogenetic damage in chagasic children treated with benznidazole.
Chromosomal aberrations and induction of micronuclei were analyzed from cultures of peripheral lymphocytes in 2 groups of chagasic children, before and after treatment with benznidazole. The median incidence of micronucleated interphase lymphocytes (20 patients) and chromosomal aberrations (10 patients) increased from control values of 5/1000 and 3% to 11.5/1000 and 6%, respectively, at a significance of P = 0.05.
D002467:Cell Nucleus / Q000187:drug effects; D014355:Chagas Disease / Q000188:drug therapy* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D004249:DNA Damage; D005260:Female; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D008297:Male; D009153:Mutagens / Q000009:adverse effects*; D009593:Nitroimidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000009:adverse effects*
D009153:Mutagens; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C009999:benzonidazole