Immunoglobulin-producing cells in secretory immune system in patients with selective IgA deficiency.
This study evaluated the class distribution and J chain-positivity of immunoglobulin-producing cells (Ig-PCs) in gastrointestinal mucosa and salivary glands of Japanese patients with selective IgA deficiency. The proportional patterns of gland-associated Ig-PCs showed an increase in not only IgM cells but also IgG cells, most of which were J chain-positive. This may represent a maturation arrest at B cell differentiation, rather than a compensatory phenomenon. No patients showed an increase of IgD cells in salivary glands. This behavior of IgD cells in Japanese patients may reflect associated diseases or ethnic difference in B cell differentiation.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000921:Antibody-Producing Cells / Q000276:immunology*; D004406:Dysgammaglobulinemia / Q000276:immunology*; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis / Q000172:deficiency* / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D007144:Immunoglobulin J-Chains / Q000032:analysis / Q000276:immunology*; D007075:Immunoglobulin M / Q000032:analysis / Q000276:immunology; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012469:Salivary Glands / Q000276:immunology
D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007144:Immunoglobulin J-Chains; D007075:Immunoglobulin M