Effects of D-5-hydroxytryptophan and D-DOPA on binding at serotonin and dopamine receptors.
Binding of the D-amino acids D-5-hydroxytryptophan (D-5-HTP) and D-dihydroxyphenylalanine (D-DOPA) to high affinity sites for serotonin (5-HT) and dopamine (DA) was studied in bovine striatum. D-5-HT bound to the 5-HT site with affinity in the micromolar range, but showed no appreciable binding at the DA site. D-DOPA showed little binding to either 5-HT or DA receptors.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D002417:Cattle; D002928:Cinanserin / Q000378:metabolism; D004295:Dihydroxyphenylalanine / Q000494:pharmacology*; D006220:Haloperidol / Q000378:metabolism; D066298:In Vitro Techniques; D008784:Methysergide / Q000378:metabolism; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*
D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D004295:Dihydroxyphenylalanine; D006916:5-Hydroxytryptophan; D006220:Haloperidol; D002928:Cinanserin; D008784:Methysergide