Whole-body autoradiography of tumor-bearing hamsters with a new tumor imaging agent, indium-111-labeled porphyrin.
We have synthesized a new tumor imaging agent, 111In-labeled porphyrin (111In-ATN-2). In order to image transplantable pancreatic carcinoma in Syrian golden hamsters, we investigated the biodistribution of 111In-ATN-2 72 hr after injecting the agent by means of whole-body autoradiography. The efficacy of the agent was compared with that of 67Ga citrate. The images with 111In-ATN-2 were found to be clearer than those with 67Ga citrate. Tumor-to-tissue radiodistribution ratios of the former were higher than those of the latter. Thus, 111In-ATN-2 seems to be more useful for tumor diagnosis.
D000818:Animals; D001345:Autoradiography; D006224:Cricetinae; D005710:Gallium Radioisotopes; D007205:Indium Radioisotopes; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging*; D011166:Porphyrins; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D005710:Gallium Radioisotopes; D007205:Indium Radioisotopes; D011166:Porphyrins; C057315:ATN-2