title: Prenatal diagnosis of hematologic diseases, 1986 update.
abstract: Prenatal diagnosis has been performed in more than 11,000 fetuses at risk for hematologic diseases. This paper summarizes the data from 30 centers from 1974 to 1985: 70% had fetal blood taken for hemoglobinopathies, of which 93% were for thalassemia and 7% for sickle disorders; 13% had DNA analyses for hemoglobinopathies, 54% for thalassemia and 46% for sickle disorders; 17% were investigated for other hematologic diseases using fetal blood, while 0.1% of the cases were studied for other diseases by DNA techniques. Error rates for all types of studies were under 1%, and fetal losses below 4%. Approximately 95% of families received safe, accurate information.
mesh_terms: D002824:Chorionic Villi / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000032:analysis; D005260:Female; D005312:Fetal Blood; D005333:Fetus / Q000032:analysis; D006402:Hematologic Diseases / Q000175:diagnosis*; D006403:Hematologic Tests; D006405:Hematology / Q000379:methods / Q000639:trends; D006453:Hemoglobinopathies / Q000175:diagnosis; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods / Q000639:trends
chemical_list: D004247:DNA