title: The role of genes LAC1 and LAC2 in the biosynthesis of lactose metabolism enzymes by Kluyveromyces lactis.
abstract: By crossing different Kluyveromyces lactis strains, the role of genes LAC1, LAC2 and of gene C were analyzed. These genes are involved in the biosynthesis of enzymes for the metabolism of lactose and galactose. They control the biosynthesis of the lactose and galactose transport, of beta-galactosidase and of the three enzymes of the Leloir pathway. The presence of at least one of the LAC gene is required for the biosynthesis to occur. The gene C seems to code for a negative factor which blocks the expression of the LAC1 and LAC2 genes in the absence of an inducer.
mesh_terms: D001692:Biological Transport; D004790:Enzyme Induction; D005686:Galactokinase / Q000378:metabolism; D005690:Galactose / Q000378:metabolism; D005700:Galactosyltransferases / Q000378:metabolism; D005786:Gene Expression Regulation; D005800:Genes, Fungal; D005990:Glycerol / Q000502:physiology; D007716:Kluyveromyces / Q000235:genetics* / Q000378:metabolism; D007785:Lactose / Q000378:metabolism*; D010641:Phenotype; D019998:Racemases and Epimerases / Q000378:metabolism; D004718:Saccharomycetales / Q000235:genetics*; D001616:beta-Galactosidase / Q000378:metabolism
chemical_list: D005700:Galactosyltransferases; D005686:Galactokinase; D001616:beta-Galactosidase; D019998:Racemases and Epimerases; D007785:Lactose; D005990:Glycerol; D005690:Galactose