Rat milk stimulates pituitary growth hormone secretion of neonatal pituitaries in vitro.
Aqueous extracts of rat milk stimulated growth hormone (GH) secretion from superfused pituitaries of two-day old rats. The GH stimulatory effect of milk increased with the time elapsed postpartum; growth hormone releasing hormone and thyrotropin releasing hormone seem to be the major milk borne GH releasing factors. These results indicate that milk intake may play a role in maintaining the high plasma GH levels observed in the neonatal period.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D018756:GABA Antagonists; D013006:Growth Hormone / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology; D008892:Milk / Q000502:physiology*; D010121:Oxytocin / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D018756:GABA Antagonists; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D010121:Oxytocin; D010852:Picrotoxin; D013973:Thyrotropin-Releasing Hormone; D005680:gamma-Aminobutyric Acid