[Establishment of a transformed line of arterial smooth muscle cells].
Biology of the vascular cells is widely studied by means of cell culture techniques. In the present work the description of a transformed cell line of arterial smooth muscle cells is presented. The cell line, named V8, has been established from cells of adult rat aortic media. The cells presented proliferation characteristics in vitro, in soft agar, and in vivo in nude mice demonstrating a tumorigenic ability. This cell line provides an interesting model for the study of growth regulation of arterial smooth muscle cells specially in the areas of hypertension and atherosclerosis.
D000818:Animals; D001011:Aorta; D001161:Arteriosclerosis / Q000473:pathology; D002455:Cell Division; D002461:Cell Line, Transformed; D004730:Endothelium, Vascular / Q000166:cytology; D004847:Epithelial Cells; D051379:Mice; D008819:Mice, Nude; D008854:Microscopy, Electron; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D009368:Neoplasm Transplantation; D051381:Rats
Etablissement d'une lignée transformée de cellules musculaires lisses artérielles.