Platelet serotonin transport after a single ECT.
Platelet 5-HT uptake was examined in six depressed patients before and after a single electroconvulsive treatment and compared with six age- and sex-matched controls. The depressed patients had a significantly (P less than 0.05) lower Vmax of platelet 5-HT uptake prior to ECT (22.9 +/- 7.6 pm/2 x 10 platelets) than did control subjects (37.5 +/- 9.1 SEM). After a single ECT treatment, the Vmax significantly (P less than 0.05) increased to levels (34.6 +/- 10.1)no longer significantly different from control. The results are compared with recent data from depressed patients indicating that low baseline levels of platelet imipramine binding increase after ECT treatment.
D000328:Adult; D000368:Aged; D001692:Biological Transport; D001792:Blood Platelets / Q000378:metabolism*; D003866:Depressive Disorder / Q000097:blood / Q000628:therapy; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000493:pharmacokinetics*
D012701:Serotonin