Impotence: treatment by autoinjection of vasoactive drugs.
One hundred and twenty five men with psychogenic or organic impotence used autoinjection of the penile corpora cavernosa with either papaverine or papaverine and phentolamine for a mean period of 10.5 months (range 1-24 months) to achieve penile erection for sexual intercourse. Prolonged (over four hours) painless erection resulted from 34 of the 3513 self administered injections. This seems to be a highly effective approach to treating impotence irrespective of the aetiology.
D000328:Adult; D000368:Aged; D004338:Drug Combinations; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000008:administration & dosage* / Q000627:therapeutic use; D010410:Penile Erection / Q000187:drug effects; D010646:Phentolamine / Q000008:administration & dosage* / Q000627:therapeutic use; D012646:Self Administration
D004338:Drug Combinations; D010208:Papaverine; D010646:Phentolamine