Sister-chromatid exchanges in lymphocytes from patients with Schistosoma hematobium.
Sister-chromatid exchange (SCE) frequencies were studied in peripheral blood lymphocytes from 19 patients (13 males and 6 females) with Schistosoma hematobium, prior to the initiation of chemotherapy. The mean frequency of SCE per metaphase for the patients (both sexes) was 10.4 +/- 4.2 which was significantly higher (P less than 0.01) than the mean SCE (6.4 +/- 1.1) score for 35 healthy controls. A highly significant reduction in lymphocyte division and delay in cell-cycle progression as a result of infection were also noticed. These data indicate that infection with S. hematobium could increase SCEs in the host somatic cells.
D000293:Adolescent; D000328:Adult; D002453:Cell Cycle; D002478:Cells, Cultured; D002648:Child; D004249:DNA Damage; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000502:physiology; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D012553:Schistosomiasis haematobia / Q000235:genetics*; D012854:Sister Chromatid Exchange
D007073:Immunoglobulin E