Enhanced fibrinolysis caused by tissue plasminogen activator release in hemodialysis.
The effect of hemodialysis on components of the fibrinolytic system was measured in 22 patients. Plasma levels of t-PA antigen, t-PA activity, u-PA antigen and plasminogen activator inhibitor were determined by means of immunological and functional assays. During hemodialysis, 11 patients exhibited an increase in t-PA antigen within the first hour to about three times the starting values (P less than 0.05), followed by a decrease to about double of the initial values until the end of the treatment. Eleven patients showed a continuous increase up to 200% of the starting values until the end of hemodialysis. u-PA levels did not change significantly during the time of investigation (P greater than 0.5).
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005342:Fibrinolysis; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D015849:Plasminogen Inactivators; D006435:Renal Dialysis / Q000009:adverse effects*; D010959:Tissue Plasminogen Activator / Q000097:blood / Q000378:metabolism*; D014511:Uremia / Q000097:blood / Q000628:therapy; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood
D006023:Glycoproteins; D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator