title: Fortified antibiotic ointment in bacterial keratitis.
abstract: We conducted experiments to determine the effectiveness of fortified antibiotic ointment in the treatment of Pseudomonas keratitis in rabbits. We evaluated gentamicin ointment (3, 10, 20, and 40 mg/g), gentamicin solution (3 and 10 mg/ml), and placebo, each given every 30 minutes. We also examined the effectiveness of fortified ointment given in extended treatment intervals. In short-term trials, commercial-strength gentamicin solution (3 mg/ml) was therapeutically superior (P less than .001) to commercial-strength gentamicin ointment (3 mg/g) in reducing corneal bacterial colony counts. No significant difference in antimicrobial effect was noted between fortified gentamicin ointment and fortified gentamicin solution at 30-minute treatment intervals. Fortified gentamicin ointment reduced colony counts even at extended treatment intervals of up to four hours in a severe keratitis model.
mesh_terms: D000818:Animals; D005839:Gentamicins / Q000008:administration & dosage*; D007634:Keratitis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D009824:Ointments; D011552:Pseudomonas Infections; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D011817:Rabbits; D012996:Solutions
chemical_list: D005839:Gentamicins; D009824:Ointments; D012996:Solutions