Dopamine depletion protects striatal neurons from ischemia-induced cell death.
Infusion of the dopamine neurotoxin 6-hydroxydopamine, unilaterally into the substantia nigra of rats, resulted in a unilateral depletion of dopamine in the ipsilateral striatum. When these rats were subjected to global forebrain ischemia by the four-vessel occlusion technique, there was a significant protection of the dopamine depleted striatum from the ischemia-induced loss of medium sized neurons seen in the intact striatum. These results imply a role for dopamine in ischemia-induced striatal cell death.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D003714:Denervation; D004298:Dopamine / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology*; D002546:Ischemic Attack, Transient / Q000473:pathology* / Q000517:prevention & control; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects / Q000473:pathology*
D006892:Hydroxydopamines; D016627:Oxidopamine; D004298:Dopamine