The effect of renal failure and haemodialysis on the concentration of free apolipoprotein A-1 in serum and the implications for the catabolism of high-density lipoproteins.
Free apolipoprotein A-1 (free A-1) was measured by quantitative crossed immunoelectrophoresis in 43 patients with severe chronic renal failure. The free A-1 concentrations in these patients were higher than in 28 healthy subjects irrespective of whether they where receiving haemodialysis or conservative treatment. A close correlation was found between serum concentration of free A-1 and creatinine in patients with varying degrees of chronic renal failure (r = 0.717, p less than 0.001). In three patients who received renal transplants serial measurements of free A-1 showed a decrease to normal levels within two days post-operatively. These findings suggest a relationship between the serum concentration of free A-1 and glomerular filtration. In conjunction with the report implicating the kidney as the major site of catabolism of Apo A-1 in the rat, these results suggest a similar role for the kidney in man. No evidence has been found linking free A-1 with hypertriglyceridaemia in patients with renal failure as has been suggested previously.
D000293:Adolescent; D000328:Adult; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000097:blood*; D008076:Cholesterol, HDL / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D007668:Kidney / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014280:Triglycerides / Q000378:metabolism
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D014280:Triglycerides; D003404:Creatinine