Lithium-induced thyroid disorders: a prevalence study.
A group of 116 lithium-treated patients (53 men, 63 women) with predominant diagnoses of affective disorders were systematically examined for the presence of thyroid disorders. Nine (7.8%) patients (2 men, 7 women) were found to suffer from hypothyroidism after a mean of 3.4 years of lithium therapy. An increase in thyroid-stimulating hormone without clinical hypothyroidism was noted in 2 (1.7%) patients (both men). Hyperthyroidism with a full-blown picture of thyrotoxic nodular goiter was noted in 1 woman, and temporary increases in thyroxine and triiodothyronine were noted in another woman. These findings are discussed in light of other studies.
D000368:Aged; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D006042:Goiter / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced / Q000453:epidemiology; D007037:Hypothyroidism / Q000139:chemically induced / Q000453:epidemiology; D008094:Lithium / Q000009:adverse effects*; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged; D011792:Quebec; D013959:Thyroid Diseases / Q000139:chemically induced* / Q000453:epidemiology; D013972:Thyrotropin / Q000097:blood
D016651:Lithium Carbonate; D013972:Thyrotropin; D008094:Lithium