[Usefulness of the evaluation of plasma levels of primidone and phenobarbital].
We tested 187 blood samples to measure Primidone and Phenobarbital plasma levels. 63 were on monotherapy, whereas 124 on polytherapy. We founded a good relationship between PRI dosage and PB plasma levels. However, from our data, we can't find any correlation between PRI dosage and PRI level. Looking at correlations of polytherapy, BDZ and DPA do not change PRI and PB levels, whereas CBZ and DPH increase PB and decrease PRI, probably by inducing the biotransformation of the drug. In conclusion, we suggest the usefulness to measure together PRI and PB levels in order to obtain the best evaluation.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001569:Benzodiazepines / Q000008:administration & dosage; D002220:Carbamazepine / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D010634:Phenobarbital / Q000097:blood*; D010672:Phenytoin / Q000008:administration & dosage; D011324:Primidone / Q000097:blood*; D014635:Valproic Acid / Q000008:administration & dosage
D001569:Benzodiazepines; D011324:Primidone; D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin; D010634:Phenobarbital
Utilità della valutazione dei livelli plasmatici di primidone e fenobarbitale.