Effects of administration of N-nitrosodialkylamines and N-nitrodiethylamine on hepatic UDP-glucuronosyltransferase activity in Wistar rats.
N-Nitrosodiethylamine (NEN) and N-nitrodiethylamine (NEA) are carcinogens and in vitro activators of hepatic UDP-glucuronosyltransferase (GT) toward 2-aminophenol (AP) and 4-nitrophenol (NP). In this communication, they were intraperitoneally administered to male Wistar rats for 7 days and GT activities were determined towards AP, NP, phenolphthalein (PH) and testosterone (TS). Administration of 30 or 20 mg/kg dose of NEN caused marked decrease of liver and body weights, and did not affect hepatic GT activities. Injection of 10 mg/kg dose of NEN did not diminish liver and body weights, and increased the maximally activated GT activities toward AP and NP. In contrast, 30 mg/kg dose of NEA, did not affect either liver and body weights or GT activities. N-Nitrosodimethylamine (NMN), which is a carcinogen and a weak in vitro AP GT activator, was more toxic than NEN, and 3.6 mg/kg dose of NMN appears to induce GT toward NP and AP. Administration of 46.5 mg/kg N-nitrosodibutylamine (NBN), which is a carcinogen but not a GT activator, did not affect GT activities or liver body weights.
D000627:Aminophenols / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004048:Diethylamines / Q000008:administration & dosage / Q000494:pharmacology*; D004052:Diethylnitrosamine / Q000008:administration & dosage / Q000494:pharmacology*; D004128:Dimethylnitrosamine / Q000008:administration & dosage / Q000494:pharmacology*; D014453:Glucuronosyltransferase / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009596:Nitrophenols / Q000378:metabolism; D009602:Nitrosamines / Q000008:administration & dosage / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000627:Aminophenols; D004048:Diethylamines; D009596:Nitrophenols; D009602:Nitrosamines; C027667:2-aminophenol; D004052:Diethylnitrosamine; C012279:dibutylnitrosamine; C031406:N-nitrodiethylamine; D014453:Glucuronosyltransferase; D004128:Dimethylnitrosamine; C024836:4-nitrophenol