[Comparative bactericidal kinetics of ciprofloxacin, ofloxacin and pefloxacin alone and in combination against strains of group D Streptococcus].
Killing curves method was used to study bactericidal activity of the three quinolones, alone and in combination with penicillin, amoxicillin, fosfomycin, netilmicin, vancomycin against six isolates of enterococci. Alone, ofloxacin showed the most initial bactericidal effect but ciprofloxacin was the most frequently bactericidal without any regrowth in 24 hours. The combinations with beta-lactams and netilmicin were sometimes synergistic in 24 hours; fosfomycin increased initial bactericidal effect.
D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D004357:Drug Synergism; D013293:Enterococcus faecalis / Q000187:drug effects*; D005578:Fosfomycin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009428:Netilmicin / Q000494:pharmacology; D009643:Norfloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology*; D015366:Pefloxacin; D010400:Penicillin G / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010078:Oxazines; D015366:Pefloxacin; D005578:Fosfomycin; D009428:Netilmicin; D002939:Ciprofloxacin; D014640:Vancomycin; D000658:Amoxicillin; D015242:Ofloxacin; D009643:Norfloxacin; D010400:Penicillin G
Cinétiques de bactéricidie comparées de la ciprofloxacine, de l'ofloxacine et de la péfloxacine seules et en association sur des souches de streptocoques du groupe D.