Effects of vanillin on sister-chromatid exchanges and chromosome aberrations induced by mitomycin C in cultured Chinese hamster ovary cells.
Effects of vanillin on the induction of sister-chromatid exchanges (SCEs) and structural chromosome aberrations by mitomycin C (MMC) were investigated in cultured Chinese hamster ovary cells. Vanillin induced neither SCEs nor chromosome aberrations by itself. However, an obvious increase in the frequency of SCEs was observed when MMC-treated cells were cultured in the presence of vanillin. The effect of vanillin was S-phase-dependent. On the contrary, the frequency of cells with chromosome aberrations was significantly decreased by the post-treatment with vanillin at G2 phase.
D000818:Animals; D001547:Benzaldehydes / Q000008:administration & dosage*; D002453:Cell Cycle / Q000187:drug effects; D002460:Cell Line; D002869:Chromosome Aberrations; D006224:Cricetinae; D004334:Drug Administration Schedule; D004357:Drug Synergism; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D001547:Benzaldehydes; D008937:Mitomycins; D016685:Mitomycin; C100058:vanillin