Response of the wild type and low xanthine dehydrogenase strains of Drosophila melanogaster to adenine resistance selection.
Survival rates of two Drosophila melanogaster strains, the Oregon R Wild Type (WT), and a mutant that was Low Xanthine Dehydrogenase (LXD), grown for six generations in control and in adenine-supplemented media, were determined. Although adenine was toxic to both strains, it was less toxic to the LXD strain. Uric acid levels indicated that WT Drosophila melanogaster was less able to metabolize adenine through the detoxification pathway. Male flies of both strains appeared to be more susceptible to adenine toxicity than were female. The results demonstrate that the adenine resistant strain may possess an enzyme pattern to minimize the toxic effect of adenine.
D000225:Adenine / Q000494:pharmacology*; D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D004351:Drug Resistance; D005260:Female; D007658:Ketone Oxidoreductases / Q000235:genetics*; D008297:Male; D009154:Mutation; D012727:Sex Characteristics; D014527:Uric Acid / Q000378:metabolism; D014968:Xanthine Dehydrogenase / Q000235:genetics*
D014527:Uric Acid; D014968:Xanthine Dehydrogenase; D007658:Ketone Oxidoreductases; D000225:Adenine