Kainic acid induced damage to the striatum increases DT diaphorase activity.
A significant increase in the striatal specific activity of DT diaphorase is demonstrable from one to six weeks after intrastriatal injection of kainic acid (KA). At six weeks, there is a significant dose-response relation (ANOVA, F(2,18) = 25.8, p less than 0.001); 1, 3 and 5 nmoles produce 12.3, 39.6 and 118% increases, respectively. Loss of acetylcholinesterase activity (AChE), used as an indicator of neuronal damage, is positively correlated with the enhanced DT diaphorase activity (r = 0.823, p less than 0.01).
D000110:Acetylcholinesterase / Q000032:analysis; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D016660:NAD(P)H Dehydrogenase (Quinone); D011808:Quinone Reductases / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D016660:NAD(P)H Dehydrogenase (Quinone); D011808:Quinone Reductases; D000110:Acetylcholinesterase; D007608:Kainic Acid