title: Double-stimulation with LH-RH in primary amenorrhea caused by chronic internal hydrocephylus: a case study.
abstract: A 19-year-old female patient with primary amenorrhea and pubertas tarda due to chronic internal hydrocephalus presented with normal hormonal findings except for low estradiol and a prepubertal type of reaction in the double-stimulation test with LH-RH. After successful operative treatment with a Spitz-Holter high-pressure valve, the intracranial decompression was promptly followed by pubertal development, she began to menstruate, and the LH-RH double-stimulation test showed an adult pattern of response. The results of the test support the view that a partial deficiency in the secretion of LH-RH is the cause of hypogonadism in such a case.
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000097:blood*; D002557:Cerebrospinal Fluid Shunts; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D006849:Hydrocephalus / Q000097:blood* / Q000601:surgery; D007427:Intracranial Pressure; D007986:Luteinizing Hormone / Q000097:blood; D011628:Puberty, Delayed / Q000097:blood*
chemical_list: D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone