title: In vitro evaluation of josamycin, spiramycin, and erythromycin against Rickettsia rickettsii and R. conorii.
abstract: The antimicrobial activities of josamycin, erythromycin, and spiramycin against Rickettsia conorii and R. rickettsii were evaluated in two tests: a dye-uptake assay and a plaque assay. The MIC of josamycin was 1 microgram/ml for both species; the MICs of erythromycin and spiramycin were 4 to 8 and 16 to 32 micrograms/ml, respectively, for both species. Only josamycin may be of clinical use in treating spotted fever rickettsiosis. It may be useful in treating pregnant women and young children.
mesh_terms: D000818:Animals; D004917:Erythromycin / Q000494:pharmacology*; D007933:Leucomycins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D012281:Rickettsia / Q000187:drug effects*; D012284:Rickettsia rickettsii / Q000187:drug effects*; D014709:Vero Cells
chemical_list: D007933:Leucomycins; D004917:Erythromycin