Rise in plasma trimethyllysine levels in humans after oral lysine load.
Oral administration of 5 g of lysine to healthy male volunteers produced a marked and progressive rise in plasma trimethyllysine (TML) from 3 to 24 h after the lysine load. Urinary TML did not register a similar rise. Plasma and urinary carnitine also increased after the lysine load. A similar rise in TML or carnitine was not seen after a 5 g tryptophan load. This suggests that the effect is specific for lysine and is not a nonspecific consequence of amino acid load.
D000284:Administration, Oral; D000328:Adult; D002331:Carnitine / Q000097:blood / Q000652:urine; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology* / Q000652:urine; D008297:Male; D013997:Time Factors; D014364:Tryptophan / Q000494:pharmacology
C003712:trimethyllysine; D014364:Tryptophan; D008239:Lysine; D002331:Carnitine