title: Studies on mikamycin B lactonase. V. Metabolic control in mikamycin B fermentation.
abstract: In mikamycin B fermentation, some procedures were examined to remove the participation of mikamycin B lactonase, which reduces mikamycin B titers. Addition of enzyme inhibitors and control of pH resulted in the elimination of the enzyme activity, and in the stimulation of antibiotic production.
mesh_terms: D002265:Carboxylic Ester Hydrolases / Q000502:physiology; D003300:Copper / Q000494:pharmacology; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D013302:Streptomyces / Q000378:metabolism*; D014769:Virginiamycin / Q000096:biosynthesis*
chemical_list: D014769:Virginiamycin; D003300:Copper; D002265:Carboxylic Ester Hydrolases; C021800:mikamycin B lactonase