Gastric alpha heavy chain disease.
Clinicopathological and immunohistological features of 4 cases of gastric lymphomas with alpha-heavy chain disease (AHCD) are described. Clinically there were no reliable features that could distinguish them from the 'western' types of gastric lymphomas (WGL). Two of the 4 had diffuse mucosal involvement reminiscent of the more common intestinal form of AHCD. Histologically, all 4 were low-grade follicular-centre cell lymphomas with plasmacytic differentiation. The diagnosis of gastric AHCD and its implications are discussed.
D000328:Adult; D003937:Diagnosis, Differential; D005753:Gastric Mucosa / Q000473:pathology; D006362:Heavy Chain Disease / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007137:Immunoglobulin alpha-Chains; D008223:Lymphoma / Q000175:diagnosis / Q000473:pathology; D008297:Male; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000473:pathology*
D007137:Immunoglobulin alpha-Chains