title: Dimeric opioid antagonists.
abstract: Symmetrical and unsymmetrical dimeric pentapeptide opioid antagonists have been prepared and studied on the mouse vas deferens preparation. The findings do not support the hypothesis that such agents bind to dimeric delta-opioid receptors.
mesh_terms: D000818:Animals; D004723:Endorphins / Q000037:antagonists & inhibitors; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009292:Narcotic Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013816:Thermodynamics; D014649:Vas Deferens / Q000187:drug effects / Q000502:physiology
chemical_list: D004723:Endorphins; D009292:Narcotic Antagonists