title: Analysis of worm burdens in experimental schistosomiasis.
abstract: The techniques of generalized linear modelling were applied to worm burdens of 2268 mice artificially infected with Schistosoma mansoni and treated with oxamniquine and/or praziquantel. Models which maximized the Poisson likelihood were shown to be superior to those assuming either a log Normal or negative binomial error structure. Use of the models to calculate and compare ED values of 8 strains of S. mansoni, detect abnormal dose response and synergism and to pool data from several experiments is illustrated.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D008297:Male; D051379:Mice; D008954:Models, Biological; D009600:Nitroquinolines / Q000627:therapeutic use*; D010073:Oxamniquine / Q000494:pharmacology / Q000627:therapeutic use*; D011223:Praziquantel / Q000494:pharmacology / Q000627:therapeutic use*; D011336:Probability; D012550:Schistosoma mansoni / Q000187:drug effects / Q000254:growth & development*; D012555:Schistosomiasis mansoni / Q000188:drug therapy / Q000469:parasitology*; D012984:Software
chemical_list: D009600:Nitroquinolines; D010073:Oxamniquine; D011223:Praziquantel