Reduced virulence in ciprofloxacin-resistant variants of Pseudomonas aeruginosa strains.
Pseudomonas aeruginosa strains resistant to ciprofloxacin were obtained from parental strains by serial transfer through subinhibitory concentrations of the drug. They showed reduced virulence for mice, and also increased sensitivity to aminoglycosides.
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000235:genetics / Q000472:pathogenicity*; D013045:Species Specificity; D014774:Virulence
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin