[Prognostic significance of changes in the levels of histamine and other factors in patients with acute cerebral circulatory disorders].
Histamine (H) levels in the cerebrospinal fluid and blood were studied in 95 patients with acute cerebral circulation impairments (ACCI). The results obtained were collated with a number of clinical and biochemical parameters and with some parameters of the gaseous homeostasis. The author used the spectrofluorometric assay of H and serotonin (S) in the biological fluids and was the first to establish an elevation of H levels in the blood and CSF prior to an aggravation of the patient's status, in cases of a remittent course and in protracted hypertensive crises; she also revealed a heterogeneous nature of changes in the blood concentrations of H and S in patients with ACCI, as well as a direct correlation between C concentrations in the blood and pCO2 and an inverse correlation between H levels in the blood and pCO2 levels. It has been demonstrated that in cases of ACCI both H levels, and the H/S ratio and blood gases assessed in combination have prognostic significance. The results obtained have both theoretical and prognostic significance with regard to ACCI research.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D002245:Carbon Dioxide / Q000097:blood; D002561:Cerebrovascular Disorders / Q000378:metabolism*; D005260:Female; D006632:Histamine / Q000032:analysis*; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011379:Prognosis; D012701:Serotonin / Q000032:analysis; D013997:Time Factors
D002245:Carbon Dioxide; D012701:Serotonin; D006632:Histamine; D010100:Oxygen
Prognosticheskoe znachenie izmeneniĭ urovnia gistamina i nekotorykh drugikh faktorov u bol'nykh s ostrymi narusheniiami mozgovogo krovoobrashcheniia.