A possible role for prostaglandins in the expression of morphine dependence in guinea-pig isolated ileum.
1. The effects of the cyclo-oxygenase inhibitors, indomethacin (1.3 microM) and mefenamic acid (10 microM), were investigated on the naloxone-precipitated withdrawal contracture of the morphine-dependent guinea-pig ileum in vitro. 2. Both indomethacin and mefenamic acid prevented expression of the withdrawal contracture on naloxone challenge. 3. The effects of indomethacin were reversed by the concurrent application of a low dose of prostaglandin E1 (10 nM). 4. It was concluded that prostaglandins probably play a role in the expression of morphine withdrawal in this model.
D000527:Alprostadil / Q000494:pharmacology; D000818:Animals; D016861:Cyclooxygenase Inhibitors; D006168:Guinea Pigs; D007082:Ileum / Q000503:physiopathology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009021:Morphine Dependence / Q000503:physiopathology*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000503:physiopathology*; D009270:Naloxone / Q000494:pharmacology; D011453:Prostaglandins / Q000502:physiology*
D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D009270:Naloxone; D000527:Alprostadil; D007213:Indomethacin