[Status of carnitine in clinical nutrition. An explanatory trial].
During total parenteral alimentation of rats it could be demonstrated that carnitine supplementation in small (10 mg/kg B.W./day) and high (100 mg/kg B.W./day) amounts leads to an increased and only slightly elevated ketogenesis. The lower ketogenicity when carnitine is supplemented in high amounts is explained as a substrate withdrawal as a consequence of an outward transport of long-chain fatty acids in the form of carnitine conjugates from the mitochondrial matrix space. This reaction leads at the same time to an increased availability of mitochondrial CoA.
D000818:Animals; D002331:Carnitine / Q000008:administration & dosage* / Q000378:metabolism; D002333:Carnitine Acyltransferases / Q000378:metabolism; D003065:Coenzyme A / Q000378:metabolism; D004734:Energy Metabolism; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage* / Q000378:metabolism; D008930:Mitochondria, Liver / Q000201:enzymology; D010289:Parenteral Nutrition, Total; D051381:Rats; D014280:Triglycerides / Q000008:administration & dosage
D005217:Fat Emulsions, Intravenous; D014280:Triglycerides; D002333:Carnitine Acyltransferases; D002331:Carnitine; D003065:Coenzyme A
Die Stellung von Carnitin in der klinischen Ernährung. Ein Erklärungsversuch.