Mononeuritis multiplex in Waldenström's macroglobulinemia.
We describe a patient with mononeuritis multiplex who had cranial nerve involvement in association with Waldenström's macroglobulinemia. Sural nerve biopsy showed abundant endoneurial granulofibrillary deposits related to microangiopathic changes. These changes were distributed in a multifocal pattern among the fascicles. Immunohistochemistry demonstrated the IgM nature of the deposit located in the endoneurial interstitium.
D001706:Biopsy; D003389:Cranial Nerve Diseases / Q000150:complications / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009443:Neuritis / Q000209:etiology* / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology; D008258:Waldenstrom Macroglobulinemia / Q000150:complications*