[Functional interaction between the tumor necrosis factor and interleukin 2 during induction of lymphokine activated killer cytotoxic activity].
TNF has a differential effect on the induction of LAK activity which is dependent on the IL-2 concentrations used for LGL stimulation. TNF was found to synergize with low concentrations of IL-2 which are normally ineffective in inducing LAK activity. When IL-2 was used at concentrations optimal for LAK generation, TNF did not further enhance the differentiation of LGL into LAK effectors. When anti-TNF was included in the 51Cr-release assay, no effect on the cytolytic activity was observed. We also demonstrate that IL-2 induced an increase of specific TNF binding to LGL.
D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology* / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D013268:Stimulation, Chemical; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology* / Q000494:pharmacology
D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha
Interaction fonctionnelle entre le TNF et l'IL-2 au cours de l'induction de l'activité cytotoxique LAK.