Analgesic efficacy and tolerability of diflunisal in oral surgery.
A double-blind, completely randomized study was carried out on 169 patients to compare the analgesic efficacy and tolerability of diflunisal with that of Veralgin after surgical removal of impacted third molars. One group received 1000 mg diflunisal (Donobid, MSD) 2 h preoperatively and then 500 mg twice daily for 2.5 days, and the other group Veralgin (aminophenazon. 286 mg, barbital. 114 mg, aethylmorph. hydrochlorid. 20 mg, Orion), a fixed combination widely used in Finland, 1 tablet twice daily beginning 2 h prior to operation. Visual analogue scales were used to estimate pain. Diflunisal was found to be superior in relieving pain in the early postoperative period, the associated frequency of adverse clinical experiences was lower and the final evaluation of analgesic efficacy by both the patients and the investigators, was in its favour. The study confirms that postoperative pain after third molar surgery can be controlled well without the use of mainly centrally acting combination analgesics.
D000328:Adult; D000632:Aminopyrine / Q000008:administration & dosage / Q000627:therapeutic use*; D001462:Barbital / Q000008:administration & dosage / Q000627:therapeutic use*; D001463:Barbiturates / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004061:Diflunisal / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004338:Drug Combinations / Q000008:administration & dosage / Q000627:therapeutic use; D005036:Ethylmorphine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery; D009022:Morphine Derivatives / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011897:Random Allocation; D012459:Salicylates / Q000627:therapeutic use*; D014081:Tooth Extraction / Q000009:adverse effects*
D001463:Barbiturates; D004338:Drug Combinations; D009022:Morphine Derivatives; D012459:Salicylates; D000632:Aminopyrine; C054941:Veralgin; D001462:Barbital; D004061:Diflunisal; D005036:Ethylmorphine