Platelet aggregation is inhibited by long chain acyl-CoA.
Oleoyl coenzyme A and other acyl-CoA derivatives inhibited ADP or thrombin-induced aggregation of platelets. Arachidonic acid-induced aggregation was also inhibited, but not the slower aggregation caused by 1-oleoyl-2-acetylglycerol or tetradecanoyl-phorbol-13-acetate. Coenzyme A and free fatty acids had little or no effect, and transfer of labeled oleate from oleoyl Co-A to other lipid classes was not detected. Because acyl Co-A compounds have recently been shown to modulate protein kinase C activity, acyl Co-A may provide a useful tool for investigating activation sequences in platelets and other membranes.
D000214:Acyl Coenzyme A / Q000494:pharmacology*; D000244:Adenosine Diphosphate / Q000494:pharmacology; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D003065:Coenzyme A / Q000494:pharmacology; D004075:Diglycerides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013917:Thrombin / Q000494:pharmacology
D000214:Acyl Coenzyme A; D001095:Arachidonic Acids; D004075:Diglycerides; D010975:Platelet Aggregation Inhibitors; C017585:oleoyl-coenzyme A; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate; C038237:1-oleoyl-2-acetylglycerol; D013917:Thrombin; D013755:Tetradecanoylphorbol Acetate; D003065:Coenzyme A