title: Effect of neomycin, carbadox and length of adaptation to calorimeter on performance, fasting metabolism and gastrointestinal tract of young pigs.
abstract: Five sets of littermate gilts (8.2 +/- .19 kg average initial weight) were randomly assigned within litter to a 16% protein corn-soybean meal basal diet (B), B + .308% neomycin, or B + 55 ppm carbadox. Each set was equally-fed individually once daily for 16 d in metabolism cages and 5 d in calorimeters. The average daily feed intake for 21 d was 276 g. Oxygen consumption and CO2 production were measured during an 8- to 24-h postprandial period on d 16, 19, 20 and 21, and during a 32- to 48-h postprandial period after the d 21 feeding. Pigs were killed 50 h postprandially for gastrointestinal tract measurements. Dietary supplementation of antimicrobial agents (neomycin and carbadox) resulted in improvements (P less than .01) in daily gain and efficiency of feed utilization and lower (P less than .05) small intestinal mass in pigs. There was no difference (P greater than .05) in daily gain, feed efficiency or small intestinal mass between pigs fed neomycin- or carbadox-supplemented diets. Whole-animal fasting O2 consumption and CO2 production measured during the 8- to 24-h or 32- to 48-h postprandial period were not affected (P greater than .05) by the supplementation or the source of dietary antimicrobial agents. There were no differences (P greater than .05) in 8- to 24-h fasting O2 and CO2 measurements determined on d 16, 19, 20 and 21, indicating that adaptation to calorimeters was not needed by the pigs.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects*; D002153:Calorimetry, Indirect; D002218:Carbadox / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000378:metabolism; D004064:Digestive System / Q000033:anatomy & histology* / Q000187:drug effects; D005260:Female; D009355:Neomycin / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011810:Quinoxalines / Q000494:pharmacology*; D013552:Swine / Q000254:growth & development*
chemical_list: D011810:Quinoxalines; D002245:Carbon Dioxide; D009355:Neomycin; D002218:Carbadox