title: Benadrostin, new inhibitor of poly(ADP-ribose) synthetase, produced by actinomycetes. II. Structure determination.
abstract: Benadrostin, a new inhibitor of poly(ADP-ribose) synthetase, has been isolated from the culture broth of Streptomyces flavovirens MH499-O'F1. The structure of benadrostin was defined as 8-hydroxy-2H-1,3-benzoxazine-2,4-dione by an analysis of spectral properties and chemical studies of benadrostin and its derivatives.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D010078:Oxazines / Q000302:isolation & purification; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D010078:Oxazines; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; C057300:benadrostin