title: [Role of the mono(ADP)ribosylation of proteins in cellular regulation].
abstract: In addition to its well established role as a cofactor in redox reactions, NAD+ serves also as a substrate for a ubiquitous group of enzymes called ADP-ribosyltransferases. These enzymes are found in the cytosol and in the nucleus of eukaryotic cells, they are involved as components of pathogenic bacterial toxins, and as part of a mechanism for inactivating host cell protein biosynthetic machinery in bacteriophage-infected cells. An overview of mono(ADP)ribosylation reactions is provided.
mesh_terms: D036002:ADP Ribose Transferases; D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001419:Bacteria / Q000201:enzymology; D001427:Bacterial Toxins / Q000378:metabolism; D002477:Cells / Q000201:enzymology*; D010430:Pentosyltransferases / Q000378:metabolism; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D001427:Bacterial Toxins; D011506:Proteins; D000246:Adenosine Diphosphate Ribose; D036002:ADP Ribose Transferases; D010430:Pentosyltransferases
vernacular_title: Rol' mono(ADF)ribozilirovaniia belkov v reguliatsii aktivnosti kletok.