title: Circadian and circannual rhythms of several enzymes of lysosomal origin in human plasma.
abstract: The circadian and circannual group rhythms in the plasma concentrations of the following lysosomal enzymes were studied in women and men: beta-D-N-acetylglucosaminidase, beta-D-glucuronidase, beta-D-glucosidase, beta-D-galactosidase, alpha-D-galactosidase, alpha-L-fucosidase and alpha-D-mannosidase. The circadian rhythm was detected in all the tested enzymes of women, and only in alpha-D-galactosidase, beta-D-glucosidase, alpha-D-mannosidase and beta-D-N-acetylglucosaminidase of men. A statistically significant difference between genders in the circadian rhythm was exhibited by beta-D-galactosidase, beta-D-glucosidase, beta-D-N-acetylglucosaminidase, beta-D-glucuronidase, alpha-D-galactosidase and alpha-L-fucosidase. A circannual rhythm was detected in all the tested enzymes, with the exception of beta-D-glucuronidase and beta-D-N-acetylglucosaminidase, without any statistically significant difference between genders. The group rhythms of some of the enzymes (alpha-D-galactosidase, beta-D-glucosidase, beta-D-galactosidase) showed similar values of both circadian and circannual acrophases, suggesting that they may be subjected as a group to the same chronobiological coordination. The chronobiological rhythms of lysosomal enzymes were different from those of lactate dehydrogenase and alpha 1-antitrypsin, indicating that these rhythms are not merely reflecting fluctuations of the water content of plasma. No in-phase relationship was observed between the circadian and circannual rhythms of plasma cortisol and those of the tested lysosomal enzymes, excluding a direct chronobiological relationship between this hormone and lysosomal enzymes.
mesh_terms: D000118:Acetylglucosaminidase / Q000097:blood; D000293:Adolescent; D000328:Adult; D002940:Circadian Rhythm; D005260:Female; D005696:Galactosidases / Q000097:blood; D005966:Glucuronidase / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D008361:Mannosidases / Q000097:blood; D010507:Periodicity; D012016:Reference Values; D000515:alpha 1-Antitrypsin / Q000097:blood; D000520:alpha-Glucosidases / Q000097:blood; D005644:alpha-L-Fucosidase / Q000097:blood; D043323:alpha-Mannosidase; D001617:beta-Glucosidase / Q000097:blood
chemical_list: D000515:alpha 1-Antitrypsin; D005696:Galactosidases; D008361:Mannosidases; D000520:alpha-Glucosidases; D001617:beta-Glucosidase; D043323:alpha-Mannosidase; D005966:Glucuronidase; D005644:alpha-L-Fucosidase; D000118:Acetylglucosaminidase; D006854:Hydrocortisone