Evaluation of a two-point method for prediction of lithium maintenance dosage.
A lithium test dose method, based on the two-point method of Perry et al. (1982), was evaluated in 20 patients for the prediction of maintenance dosage of slow-release lithium carbonate tablets. These predictions were compared with the predictions obtained from the dosing chart of Cooper et al. (1973). The two-point method accurately predicted the maintenance dosage within clinically acceptable limits, but dosages predicted from the dosing chart would have yielded much higher serum lithium concentrations.
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008094:Lithium / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D016651:Lithium Carbonate; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D012044:Regression Analysis
D016651:Lithium Carbonate; D008094:Lithium