title: [Oxidation of the indole ring induced by the auto-oxidation of unsaturated lipids. Application to tryptophan residues of high and low density lipoproteins of human serum].
abstract: Tryptophan residues are rapidly destroyed during Cu2+-catalyzed autoperoxidation of human serum lipoproteins. The same phenomenon occurs in the peroxidation of arachidonic acid incorporated into phosphatidylcholine liposomes using tryptophan, tryptamine and serotonin as oxidizable substrates. Replacing arachidonic acid by cholesterol inhibits the indole ring degradation.
mesh_terms: D001095:Arachidonic Acids / Q000378:metabolism; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000097:blood / Q000378:metabolism; D008081:Liposomes / Q000378:metabolism; D010084:Oxidation-Reduction; D010713:Phosphatidylcholines / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism*
chemical_list: D001095:Arachidonic Acids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008081:Liposomes; D010713:Phosphatidylcholines; D014364:Tryptophan
vernacular_title: Oxydation du noyau indole induite par l'auto-oxydation des lipides insaturés. Application aux résidus tryptophane des lipoprotéines de haute et basse densité du sérum humain.