Polypeptide fraction from bovine factor VIII used in fluorangiography.
We report a new method of fluorangiography employing a polypeptide fraction from bovine factor VIII that has shown remarkable affinity to the endothelial surface of microvessels. Rabbits injected with this compound, labeled with fluorescein isothiocyanate, show a very delayed disappearance time of fluorescence in retinal vessels when compared with those injected with ordinary fluorescein. This allows a good observation of the late time, which is of great diagnostic advantage for several pathological conditions.
D000818:Animals; D002417:Cattle; D005591:Chemical Fractionation; D005169:Factor VIII / Q000032:analysis*; D005451:Fluorescein Angiography / Q000379:methods*; D016650:Fluorescein-5-isothiocyanate; D005452:Fluoresceins; D008297:Male; D010455:Peptides; D011817:Rabbits; D012171:Retinal Vessels / Q000033:anatomy & histology; D013861:Thiocyanates; D013997:Time Factors
D005452:Fluoresceins; D010455:Peptides; D013861:Thiocyanates; D005169:Factor VIII; D016650:Fluorescein-5-isothiocyanate