title: Observations on the implications of pathology induced by experimental schistosomiasis in baboons in evaluating the development of resistance to challenge infection.
abstract: Liver samples from 10 Schistosoma mansoni-infected baboons all yielded eggs but neither their egg counts nor duration of infection (less than 226 weeks) correlated with the slightly elevated liver collagen levels or minimal histological fibrosis observed. Approximately 10% of inert 9 and 15 micron diameter microspheres injected into the mesenteric veins of 2 baboons with acute, challenge S. mansoni infection reached their lungs (mainly 9 micron microspheres). Lung egg recoveries over 1000 were significantly less common among 175 baboons exposed once to S. mansoni infections than among 56 baboons exposed more than once. Among 221 S. mansoni-and S. haematobium-infected baboons, female worm, total tissue egg and lung egg recoveries were significantly correlated with each other but not with liver or (where available) spleen weights. Liver and spleen weights were strongly correlated with total body weight. Baboons did not develop significant liver fibrosis, even after prolonged schistosome infections. However, some liver 'leakiness' developed during acute primary and challenge infections, allowing small inert particles and eggs to pass to the lungs, but this 'leakiness' was not associated with resistance to challenge. In contrast to mice, such resistance in baboons cannot, therefore, be explained simply in terms of pathological changes due to previous infections.
mesh_terms: D000818:Animals; D001835:Body Weight; D005260:Female; D007110:Immunity, Active; D008099:Liver / Q000469:parasitology* / Q000473:pathology; D008103:Liver Cirrhosis / Q000209:etiology; D008863:Microspheres; D009929:Organ Size; D010215:Papio / Q000469:parasitology*; D010270:Parasite Egg Count; D012189:Retrospective Studies; D012553:Schistosomiasis haematobia / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000469:parasitology / Q000473:pathology*; D013154:Spleen / Q000473:pathology