[Differentiation of a normal population and of a cohort of patients presenting with a history of idiopathic thromboembolism as identified with fibrinolytic tests].
To identify persons at risk for development of thromboembolic disease, fibrinolytic and blood coagulation parameters of normal controls (n = 40) and patients (n = 40) have been compared. Four fibrinolytic parameters, i.e. fibrinolytic activity at rest (FAr), fibrinolytic response after 10 minutes of venous occlusion (delta FA10'), and resting antigenic levels of the plasmatic inhibitor of the plasminogen activators (PAI-1) and of urokinase (u-PA), showed significant differences between the two study groups. The separate and combined discriminant analysis of FAr and delta FA10' values revealed that individuals with FAr below 0.63 UI/ml or a delta FA10' below 0.98 UI/ml are at risk for development of thromboembolic disease.
D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D001780:Blood Coagulation Tests; D005260:Female; D005342:Fibrinolysis; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000037:antagonists & inhibitors; D015849:Plasminogen Inactivators; D011486:Protein C / Q000097:blood; D012307:Risk Factors; D013923:Thromboembolism / Q000503:physiopathology* / Q000517:prevention & control; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood
D006023:Glycoproteins; D015849:Plasminogen Inactivators; D011486:Protein C; D000990:Antithrombin III; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator
Discrimination d'une population normale et d'un collectif de patients ayant présenté un antécédent thromboembolique idiopathique au moyen des tests fibrinolytiques.