Autologous bone marrow transplantation in acute leukemia.
We evaluated the therapeutic efficacy of autologous bone marrow transplantation (ABMT) in 49 patients with acute leukemia, using ex-vivo-treated marrow with mafosfamide. This report summarizes data collected from 8 italian centers, involving 27 cases with acute lymphoid leukemia (ALL) and 22 cases with acute nonlymphoid leukemia (ANLL). The analysis of the results shows that the disease-free survival of ALL and ANLL are similar (45 and 52%, respectively) and no significant difference can be demonstrated between patients transplanted in CR1 or CR2, although there is a trend in favor of ABMT in CR1.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001853:Bone Marrow / Q000187:drug effects; D016026:Bone Marrow Transplantation; D002648:Child; D003520:Cyclophosphamide / Q000031:analogs & derivatives / Q000494:pharmacology; D005069:Evaluation Studies as Topic; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D011300:Preoperative Care; D014182:Transplantation, Autologous
C048341:mafosfamide; D003520:Cyclophosphamide