[Effect of benzodiazepine receptor blockade on memory processes in the mouse].
The results of study testify to a stimulating effect of benzodiazepine receptors blocators RO15-1788 and RO15-3505 on reproduction of conditioned reaction of passive avoidance in mice disturbed as a result of various procedures-"psychogenic" and cycloheximide amnesia, extinction and forgetting. A considerable antiamnesic effect of the drugs on cycloheximide amnesia models is noted, in comparison with the "psychogenic" one. RO15-3505 is more effective in the processes of extraction of memory traces under amnesia. The obtained results testify to an important contribution of benzodiazepine-GABA-ergic brain systems in inhibitory regulation of the processes of stored memory traces reproduction.
D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001570:Benzodiazepinones / Q000627:therapeutic use*; D003214:Conditioning, Classical / Q000187:drug effects; D003513:Cycloheximide / Q000037:antagonists & inhibitors; D004195:Disease Models, Animal; D005108:Extinction, Psychological / Q000187:drug effects; D005442:Flumazenil / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D001570:Benzodiazepinones; D005442:Flumazenil; C040725:Ro 15-3505; D003513:Cycloheximide
Vliianie blokady benzodiazepinovykh retseptorov na protsessy pamiati u mysheĭ.