Effect of an antiglucocorticoid (RU-38486) on hydrocortisone induction of maltase-glucosamylase, sucrase-isomaltase and trehalase in brush border membranes of suckling rats.
Induction of alpha-glycosidases by hydrocortisone in suckling rats is inhibited by the daily administration of an antiglucocorticoid (RU-38486). Conversely, RU-38486 injected daily in 15-day-old rats for 7 days does not prevent the spontaneous development of alpha-glycosidases.
D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism; D004963:Estrenes / Q000494:pharmacology*; D005260:Female; D005087:Glucan 1,4-alpha-Glucosidase / Q000096:biosynthesis*; D005938:Glucocorticoids / Q000037:antagonists & inhibitors; D005959:Glucosidases / Q000096:biosynthesis*; D006854:Hydrocortisone / Q000494:pharmacology*; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D008297:Male; D008871:Microvilli / Q000201:enzymology; D015735:Mifepristone; D009097:Multienzyme Complexes / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013394:Sucrase-Isomaltase Complex / Q000096:biosynthesis*; D014198:Trehalase / Q000096:biosynthesis*
D004963:Estrenes; D005938:Glucocorticoids; D009097:Multienzyme Complexes; D015735:Mifepristone; D005959:Glucosidases; D013394:Sucrase-Isomaltase Complex; D014198:Trehalase; D005087:Glucan 1,4-alpha-Glucosidase; D006854:Hydrocortisone