title: [Causes and therapy of organ failure: mediators, their role and therapeutic implications as exemplified by the infected patient].
abstract: Mediators from the coagulation system, the complement system, the kallikrein-kinin system and the arachidonic acid metabolism are made responsible for the pathogenesis of organ failure (ARDS) following sepsis. Products from these systems influence, directly or indirectly, vascular tone and permeability, especially in the pulmonary circulation. Besides these mediators, toxic oxygen species and proteases released from activated granulocytes and macrophages injure endothelial cells and provoke vascular leakage.
mesh_terms: D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001779:Blood Coagulation Factors / Q000502:physiology; D003167:Complement Activation; D006801:Humans; D009102:Multiple Organ Failure / Q000503:physiopathology*; D009104:Multiple Trauma / Q000503:physiopathology*; D012772:Shock, Septic / Q000503:physiopathology*
chemical_list: D001095:Arachidonic Acids; D001779:Blood Coagulation Factors; D016718:Arachidonic Acid
vernacular_title: Ursachen und Therapie von Organversagen: Mediatoren, ihr Stellenwert und therapeutische Implikationen am Beispiel des septischen Patienten.