Regulation of the metR gene of Salmonella typhimurium.
Regulation of the Salmonella typhimurium metR gene was studied by measuring beta-galactosidase levels in Escherichia coli strains lysogenic for a lambda bacteriophage carrying a metR-lacZ fusion. The results indicate that the metR gene is negatively regulated by its own gene product and that this autoregulation involves homocysteine as a corepressor. In addition, the results indicate that the metR gene is negatively regulated by the metJ gene product over a 70- to 80-fold range.
D003001:Cloning, Molecular; D004274:DNA, Recombinant; D005786:Gene Expression Regulation; D005798:Genes, Bacterial; D005809:Genes, Regulator; D006710:Homocysteine / Q000494:pharmacology; D008242:Lysogeny; D008715:Methionine / Q000096:biosynthesis*; D009154:Mutation; D012486:Salmonella typhimurium / Q000201:enzymology / Q000235:genetics*; D014805:Vitamin B 12 / Q000494:pharmacology; D001616:beta-Galactosidase / Q000235:genetics
D004274:DNA, Recombinant; D006710:Homocysteine; D008715:Methionine; D001616:beta-Galactosidase; D014805:Vitamin B 12