title: [Indices of diphtheria (antitoxic) immunity in the dynamics of the disease and its treatment in adults].
abstract: A total of 1,034 serum samples from 618 persons, including patients with different forms of diphtheria, carriers of the toxigenic forms of Corynebacterium diphtheriae, and angina patients, were studied. Analysis of the incidence of antibodies to C. diphtheriae toxin and their titers revealed that in more than half of all diphtheria patients no antibodies to C. diphtheriae toxin were detected upon admission to hospital. At the same time in 26% of the patients no antibodies were detected during the whole period of the disease; in such patients the toxic and subtoxic forms of diphtheria were registered twice as often as in seropositive patients. In 31% of the patients seronegative by the moment of hospitalization a rapid increase in the titers of antibodies C. diphtheriae toxin was observed in the course of the disease, which was indicative of the secondary character of immune response in patients who had been immunized earlier.
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D002353:Carrier State / Q000276:immunology / Q000382:microbiology; D003131:Combined Modality Therapy; D003353:Corynebacterium diphtheriae / Q000276:immunology / Q000302:isolation & purification; D004165:Diphtheria / Q000276:immunology* / Q000382:microbiology / Q000628:therapy; D004166:Diphtheria Antitoxin / Q000032:analysis*; D004168:Diphtheria Toxoid / Q000276:immunology; D005260:Female; D006801:Humans; D007109:Immunity; D008297:Male; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D004166:Diphtheria Antitoxin; D004168:Diphtheria Toxoid
vernacular_title: Pokazateli difteriĭnogo (antitoksicheskogo) immuniteta v dinamike zabolevaniia i lecheniia u vzroslykh.