Chloropolysporins A, B and C, novel glycopeptide antibiotics from Faenia interjecta sp. nov. IV. Partially deglycosylated derivatives.
Chloropolysporins A, B and C, new members of the glycopeptide antibiotic family, were enzymatically and chemically converted to their partially deglycosylated derivatives. The alpha- and beta-avoparcins were also deglycosylated by the same method. The conversions were achieved by treatments with rhamnosidase (Naringinase) and alpha-mannosidase, and by mild acid hydrolysis.
D000900:Anti-Bacterial Agents / Q000032:analysis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006020:Glycopeptides / Q000032:analysis / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000378:metabolism; D006031:Glycosylation; D008361:Mannosidases / Q000378:metabolism; D008848:Micromonosporaceae / Q000032:analysis*; D009097:Multienzyme Complexes / Q000378:metabolism; D043323:alpha-Mannosidase; D001617:beta-Glucosidase / Q000378:metabolism
D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D009097:Multienzyme Complexes; C053528:chloropolysporin B; C053529:chloropolysporin C; C053527:chloropolysporin A; D006026:Glycoside Hydrolases; D008361:Mannosidases; C039827:naringinase; D001617:beta-Glucosidase; D043323:alpha-Mannosidase; C016249:avoparcin