A test hierarchy for anti-bronchoconstrictory lipoxygenase inhibitors: in vitro and in vivo experimental tests.
A test hierarchy for potential antiasthmatic lipoxygenase inhibitors was developed which includes besides molecular and cellular test systems, the arachidonic acid-(AA)-induced contraction of lung strips and ovalbumin-induced bronchoconstriction of sensitized guinea pigs. Nordihydroguaiaretic acid, butylated hydroxyanisole, benoxaprofen, BW 755C, salicylhydroxamic acid, FLM 5011 and other substances inhibit to a different extent the AA-induced contraction of lung strips and show anti-bronchoconstrictory activities in the ovalbumin-sensitized guinea pig.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D001249:Asthma / Q000188:drug therapy; D001985:Bronchial Provocation Tests; D006168:Guinea Pigs; D016859:Lipoxygenase Inhibitors; D008168:Lung / Q000187:drug effects; D008297:Male
D001095:Arachidonic Acids; D016859:Lipoxygenase Inhibitors