[Effect of nutritional insufficiency on cell proliferation in the matrix zones of the cerebellar anlage in mice].
The work has been performed on 62 CBA mice. In the ventricular zone and in the external granular layer of the cerebellar anlage of embryos (13-17 days of the intrauterine development) mitotic index, labelled nuclei index, part of labelled mitoses have been counted. Parameters of the mitotic cycle of the matrix cells have been calculated by means of the graphic method. The proliferative pool value has been calculated. At malnutrition the cerebellar anlage structure retards in its maturation from the norm. For the matrix zones of the cerebellar anlage, higher indices of the proliferative activity are specific. At the same time, duration of the mitotic cycle of the matrix cells increases by 15-17%. It is possible, that retardation of histogenesis of the mouse cerebellar anlage, when developing under conditions of alimentary insufficiency depends on decreased rate of cell proliferation, as a result of prolonged mitotic cycle of the matrix cells.
D000818:Animals; D002455:Cell Division; D002531:Cerebellum / Q000196:embryology*; D005260:Female; D005865:Gestational Age; D051379:Mice; D008808:Mice, Inbred CBA; D008940:Mitotic Index; D010922:Placenta Diseases / Q000196:embryology*; D010927:Placental Insufficiency / Q000196:embryology*; D011247:Pregnancy; D011502:Protein-Energy Malnutrition / Q000196:embryology*
Vliianie alimentarnoĭ nedostatochnosti na proliferatsiiu kletok matriksnykh zon zachatka mozzhechka mysheĭ.