title: Lead intoxication in Sydney Harbour Bridge workers.
abstract: Thirty-eight Sydney Harbour Bridge workers were assessed for possible lead intoxication. Forty-seven per cent were found to have significant lead intoxication as assessed by calcium disodium edetate chelation (Ca EDTA) testing and were subsequently effectively and safely treated with Ca EDTA. The prevalence of neurological, constitutional, gastrointestinal and musculoskeletal symptoms was significantly greater in those with, than those without, lead toxicity. Although blood lead levels and, to a lesser extent, hematological parameters were of some use in diagnosis, they were not sufficiently sensitive and thus should not be used in screening workers at risk of lead intoxication. Ca EDTA testing remains the diagnostic method of choice. Patients exposed to lead dust and fumes, in whom symptoms of lead intoxication are present, should undergo such testing and if a positive result is obtained, then EDTA chelation therapy should be instituted.
mesh_terms: D000328:Adult; D004391:Dust / Q000009:adverse effects; D004492:Edetic Acid / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000473:pathology; D007854:Lead / Q000032:analysis; D007855:Lead Poisoning / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D008669:Metallurgy; D008875:Middle Aged; D009517:New South Wales; D009784:Occupational Diseases / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D010150:Paint / Q000009:adverse effects*; D011166:Porphyrins / Q000378:metabolism; D012008:Recurrence
chemical_list: D004391:Dust; D011166:Porphyrins; D007854:Lead; D004492:Edetic Acid