Effect of total parenteral nutrition on lipase activity in the stomach of very low birth weight infants.
Lipase activity was quantitated in gastric aspirates of 7 premature infants (gestational age 24-29 weeks) during periods of total parenteral nutrition (TPN), mixed parenteral nutrition and gavage feeding or exclusive gavage feeding. The infants were studied from birth until the establishment of exclusive gastric gavage feeding. Lipase activity in gastric aspirates (quantitated by the hydrolysis of 3H-triolein at pH 4.2 and expressed in nmol 3H-oleic acid released/min/ml gastric aspirate) did not differ significantly as a function of mode of feeding: 570 +/- 235 during TPN, 260 +/- 145 during mixed parenteral nutrition and gavage feeding, and 374 +/- 149 during exclusive gastric gavage feeding. The data suggest that, contrary to the intestine and pancreas, the digestive function of the stomach is not impaired during TPN in the very preterm infant.
D006801:Humans; D007230:Infant, Low Birth Weight / Q000378:metabolism*; D007231:Infant, Newborn; D008049:Lipase / Q000378:metabolism*; D010289:Parenteral Nutrition, Total; D013270:Stomach / Q000201:enzymology*
D008049:Lipase