c-fos proto-oncogene expression in human NK/LGL cells: expression is not constitutive and is associated with functional activation.
Unlike mature myeloid and monocytic cells and cell lines committed to terminal myelomonocytic differentiation, highly purified preparations of human natural killer cells/large granular lymphocytes (NK/LGL) did not spontaneously express the c-fos proto-oncogene. Transient expression of c-fos in NK/LGL was associated with functional activation with IL-2, IFN-gamma, LPS and PMA, which increased their cytotoxic activity, lymphokine secretion and in vitro chemotaxis. These results, together with the finding that T-cell receptor genes are in germ-line configuration in the vast majority of peripheral blood NK/LGL, are compatible with the hypothesis that these cells represent a separate hematopoietic lineage.
D002772:Cholera Toxin / Q000494:pharmacology; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000276:immunology / Q000648:ultrastructure*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D007376:Interleukin-2; D008070:Lipopolysaccharides; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D007371:Interferon-gamma; D002772:Cholera Toxin; D013755:Tetradecanoylphorbol Acetate