title: Clinical management of severe sickle cell disease.
abstract: Patients affected by sickle cell disease encounter varied and often severe clinical problems directly related to their condition and are at greater risk than the general population from particular infections, thrombosis and certain surgical pathologies. The current clinical management policies for the severe acute problems arising in these patients, and measures undertaken to prevent these where possible, are discussed.
mesh_terms: D000755:Anemia, Sickle Cell / Q000628:therapy*; D001803:Blood Transfusion; D001842:Bone and Bones / Q000098:blood supply; D003681:Dehydration / Q000150:complications / Q000628:therapy; D005078:Exchange Transfusion, Whole Blood; D006801:Humans; D010146:Pain / Q000188:drug therapy; D012189:Retrospective Studies; D012805:Sickle Cell Trait / Q000503:physiopathology / Q000628:therapy*; D014652:Vascular Diseases / Q000150:complications / Q000628:therapy