The effect of immunotherapy in hayfever patients on histamine binding capacity of blood serum proteins.
Binding of histamine (histaminopexy) by blood serum proteins of 16 hayfever patients was determined before and after treatment with Pollinex. An increase in histaminopexy by 83% in comparison to pretreatment value was observed and it was well correlated with the clinical status of the patients. Participation of this phenomenon in the mechanism of therapeutic effect of specific immunotherapy is discussed.
D000328:Adult; D000447:Aldehydes / Q000627:therapeutic use*; D000485:Allergens / Q000627:therapeutic use*; D052179:Antigens, Plant / Q000627:therapeutic use; D001798:Blood Proteins / Q000378:metabolism*; D003888:Desensitization, Immunologic; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D005976:Glutaral / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts; D011058:Pollen / Q000627:therapeutic use*; D011968:Receptors, Histamine / Q000032:analysis / Q000187:drug effects*; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood / Q000276:immunology / Q000628:therapy*; D014443:Tyrosine / Q000627:therapeutic use*
D000447:Aldehydes; D000485:Allergens; D052179:Antigens, Plant; D001798:Blood Proteins; D004338:Drug Combinations; D010936:Plant Extracts; D011968:Receptors, Histamine; D014443:Tyrosine; C014155:Parietaria judaica pollen; D005976:Glutaral