High-dose intravenous gamma-immunoglobulin infusion in the treatment of thrombotic thrombocytopenic purpura.
Thrombotic thrombocytopenic purpura has been treated with plasmapheresis, exchange transfusion, splenectomy, antiplatelet compounds, glucocorticoids, and vincristine sulfate infusion. We describe a patient with thrombotic thrombocytopenic purpura who has failed on treatment with plasmapheresis, antiplatelet compounds, glucocorticoids, and vincristine, was successfully treated with high-dose gamma-immunoglobulin infusion, and has been maintained in prolonged remission without further immunoglobulin infusion for more than 14 months at the time of this report.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000008:administration & dosage*; D007142:Immunoglobulin gamma-Chains / Q000008:administration & dosage* / Q000627:therapeutic use; D007262:Infusions, Intravenous; D011697:Purpura, Thrombotic Thrombocytopenic / Q000188:drug therapy* / Q000473:pathology; D012074:Remission Induction
D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains