Production of passive cutaneous anaphylaxis (PCA) and reversed PCA by rat IgE antibody in the mouse.
Although IgE antibody is generally characterized as a homocytotropic antibody, it has been well known for some time that mouse IgE antibody causes potent sensitization of rat skin for PCA. The present study clearly shows the reciprocal cross-sensitization of mouse skin with rat IgE molecules. PCA and RPCA were produced by rat IgE antibody in an inbred mouse strain. DS/Shi, though not in C3H/HeShi, C57BL/6JShi and BALB/cCrj strains. Sensitization of DS/Shi mouse skin for PCA with rat IgE antibody was comparable in sensitivity with that of rat skin, but lasted only for a short term in comparison with the long persistence in rat skin.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000941:Antigens / Q000276:immunology; D044482:Benzeneacetamides; D002850:Chromatography, Gel; D005260:Female; D007106:Immune Sera / Q000276:immunology; D005779:Immunodiffusion; D007073:Immunoglobulin E / Q000276:immunology* / Q000302:isolation & purification; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D010323:Passive Cutaneous Anaphylaxis; D010400:Penicillin G / Q000031:analogs & derivatives / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D012710:Serum Albumin, Bovine; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D000941:Antigens; D044482:Benzeneacetamides; D007106:Immune Sera; C015026:benzylpenicilloyl G; D012710:Serum Albumin, Bovine; D007073:Immunoglobulin E; D010400:Penicillin G