Inhibition of muscular amino acid release by lipid infusion in man.
Amino acid balances of healthy postabsorptive volunteers were investigated with the forearm technique under the influence of an intravenous infusion of triglyceride emulsions (LCT; MCT/LCT) [corrected]. A decrease of the basal muscular release of most of the amino acids, respectively an increase of pre-existent uptake rates [corrected]. In parallel, arterial concentrations of these amino acids declined. With constant insulin levels and substantially unchanged blood glucose levels, this inhibition of muscular proteolysis and/or stimulation of proteosynthesis is most probably due to the increased level of free fatty acids.
D000596:Amino Acids / Q000097:blood / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D000596:Amino Acids; D001786:Blood Glucose; D005217:Fat Emulsions, Intravenous; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides