Cyclosporine in the treatment of red cell aplasia.
A 4-year-old girl was diagnosed to have pure red cell aplasia. For 5 years, she received multiple packed red cell transfusions (average 11/year). Several therapeutic maneuvers were attempted including prednisone, oxymethalone, plasmaphoresis, high dose methyl prednisolone-to no avail. Finally, cyclosporine was administered for 5 months. This increased her reticulocyte count and cured the disease. For the last 2 years she has been in excellent health and has not required any further transfusions. The possible mechanism of action of cyclosporine in this disease is discussed.
D002675:Child, Preschool; D003524:Cyclosporins / Q000627:therapeutic use*; D004906:Erythrocyte Count; D005260:Female; D006801:Humans; D012010:Red-Cell Aplasia, Pure / Q000097:blood / Q000188:drug therapy*; D012156:Reticulocytes / Q000187:drug effects
D003524:Cyclosporins