Lymphocyte activation by B. subtilis spores.
The in vitro effect of Bacillus Subtilis spores (BSs) on lymphocyte activation was investigated by analyzing the kinetics of expression of the activation antigens MLR3, MLR4 and HLA-DR in cultures of peripheral mononuclear cells. It was found that BSs over a wide range of concentrations are capable of inducing an increased expression of these three markers and that at high BSs concentration the effect is both quantitatively and qualitatively similar to that induced by the mitogens PHA and ConA. These results suggest that T cells may be involved in the response to Bss.
D001412:Bacillus subtilis / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007700:Kinetics; D008213:Lymphocyte Activation; D013171:Spores, Bacterial / Q000276:immunology
D006684:HLA-DR Antigens