A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice.
Transgenic mice carrying an immunoglobulin enhancer-driven c-myc oncogene develop rapid-onset pre-B cell lymphomas. The incidence of these malignancies is greatly reduced when an additional transgene encoding the membrane-bound form (but not the secreted form) of human Ig mu is bred into the susceptible strain. This suppressive effect correlates with a subtle alteration in B-cell development induced by the immunoglobulin transgene.
D000011:Abelson murine leukemia virus; D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D004742:Enhancer Elements, Genetic; D005803:Genes, Immunoglobulin; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006801:Humans; D007148:Immunoglobulin mu-Chains / Q000235:genetics; D008223:Lymphoma / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000378:metabolism
D007148:Immunoglobulin mu-Chains; D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger