Effects of dimethyl sulphoxide on the synthesis of plasma proteins in the human hepatoma HepG2. Induction of an acute-phase-like reaction.
Effects of dimethyl sulphoxide (Me2SO) on the synthesis of plasma proteins by the human hepatoma cell line HepG2 were examined. Me2SO treatment resulted in decreased synthesis of albumin and alpha-fetoprotein, and in increased synthesis of haptoglobin. Plasma-protein profiles induced by Me2SO treatment were very similar to those seen in acute-phase reactions.
D000210:Acute-Phase Reaction / Q000139:chemically induced / Q000378:metabolism*; D000418:Albumins / Q000096:biosynthesis; D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis*; D002460:Cell Line; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
D000418:Albumins; D001798:Blood Proteins; D004121:Dimethyl Sulfoxide