[Contribution of human menopausal gonadotropins purified as to their FSH content in anovulatory sterility presenting a difficult treatment problem].
A preparation of HMG purified to contain only FSH (FSH 75 IU/LH less than 1 IU) was used in 26 patients who had anovulatory sterility because of sclero-polycystic ovaries. It was a selected population in that all the patients had proved to be resistant to Clomiphene Citrate and at risk with HMG therapy. Purified urinary FSH was used and monitored as classical HMG treatment. 44 treatment cycles resulted in 33 ovulatory cycles (75%) and 6 pregnancies (13.6% per cycle). The number of cases of hyperstimulation (13.6%) was low when it is compared to situations at risk when HCG was administered in 2/3 of the treatment cycles. The results obtained in a population with a bad prognosis can be considered to be very encouraging and gives purified urinary FSH a specific place in our therapeutic armamentarium.
D000328:Adult; D000858:Anovulation / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D008596:Menotropins / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000150:complications
D008596:Menotropins; D005640:Follicle Stimulating Hormone
L'apport des gonadotrophines de ménopause humaine purifiées en FSH dans les stérilités anovulatoires de traitement difficile.