title: Adenosine deaminase and purine phosphorylase activities in lymphocytes and red blood cells of patients with carcinoma of the larynx.
abstract: Lymphocytes from patients with cancer of the larynx have been characterized by the activity of two enzymes involved in purine metabolism--adenosine deaminase and purine nucleoside phosphorylase. It has been shown that purine nucleoside phosphorylase activity was 1.5-fold higher in lymphocytes of patients in comparison with a group of healthy individuals. Adenosine deaminase activity in lymphocytes was elevated three to four-fold. The authors suggest that especially the estimation of adenosine deaminase activity in lymphocytes would be a useful laboratory test in the study of immune responsiveness of patients with cancer of the larynx.
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood*; D000328:Adult; D004796:Clinical Enzyme Tests; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D008214:Lymphocytes / Q000201:enzymology*; D008875:Middle Aged; D009700:Nucleoside Deaminases / Q000097:blood*; D010430:Pentosyltransferases / Q000097:blood*; D011683:Purine-Nucleoside Phosphorylase / Q000097:blood*
chemical_list: D010430:Pentosyltransferases; D011683:Purine-Nucleoside Phosphorylase; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase