Treatment planning study for carcinoma of the esophagus: helium ions versus photons.
Helium ion radiotherapy significantly reduces dose to adjoining critical structures in the treatment of carcinoma of the esophagus when the same treatment plan is compared with megavoltage photon therapy. A five-field 18 MV photon treatment plan, selected to minimize lung dose, is compared with helium ions using the same field configuration. Dose volume histograms show target coverage, as well as dose delivered to critical structures lung, heart, mediastinum, and spinal cord. Although both helium ions and photons deliver approximately the same lung dose for this treatment plan, radiation to the heart and spinal cord from this field arrangement is significantly reduced with the helium ion beam. The concentration of dose at the tumor site, while sparing surrounding normal tissue, is characteristic of charged particle therapy, particularly with light ions, which includes particles with Z from that of protons (Z = 1) through that of neon (Z = 10).
D004938:Esophageal Neoplasms / Q000532:radiotherapy*; D006321:Heart / Q000528:radiation effects; D006371:Helium / Q000627:therapeutic use*; D006801:Humans; D008168:Lung / Q000528:radiation effects; D008482:Mediastinum / Q000528:radiation effects; D010347:Patient Care Planning; D011829:Radiation Dosage; D011836:Radiation Tolerance; D011882:Radiotherapy, High-Energy; D013116:Spinal Cord / Q000528:radiation effects
D006371:Helium