Inductions of ornithine decarboxylase and DNA synthesis in rat stomach mucosa by formaldehyde.
Administration of formaldehyde at doses of 11 to 110 mg/kg body weight by gastric intubation to male F344 rats induced up to 100-fold increase in ornithine decarboxylase activity with a maximum after 16 hr and up to 49-fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa of the stomach. These results suggest that formaldehyde has tumor-promoting activity in carcinogenesis in the glandular stomach.
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D004790:Enzyme Induction; D005557:Formaldehyde / Q000633:toxicity*; D005753:Gastric Mucosa / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D051381:Rats; D011916:Rats, Inbred F344
D005557:Formaldehyde; D004247:DNA; D009955:Ornithine Decarboxylase