title: A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells.
abstract: Zinc fingers are DNA-binding domains present in several eukaryotic regulatory proteins. We have identified a mouse gene, Krox-20, encoding a protein with three zinc fingers and whose expression is activated during G0/G1 transition in cultured cells. Serum stimulation of quiescent cells leads to rapid and transient accumulation of Krox-20 mRNA, with kinetics similar to those of the c-fos proto-oncogene. The induction does not require de-novo protein synthesis. In the mouse, Krox-20 is expressed at low levels in tissues which contain rapidly dividing cells. These properties suggest that Krox-20 encodes a transcription control factor, possibly involved in the modulation of cell proliferation.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D051767:Early Growth Response Protein 2; D005786:Gene Expression Regulation; D005796:Genes; D007399:Interphase; D008667:Metalloproteins / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D014157:Transcription Factors / Q000235:genetics*; D015032:Zinc
chemical_list: D004268:DNA-Binding Proteins; D051767:Early Growth Response Protein 2; C497327:Egr2 protein, mouse; D008667:Metalloproteins; D014157:Transcription Factors; D004247:DNA; D015032:Zinc