Role in vivo for gamma interferon in control of pneumonia caused by Chlamydia trachomatis in mice.
In a model of pneumonia caused by murine Chlamydia trachomatis, depletion experiments with monoclonal antibody to gamma interferon (IFN-gamma) made mice more susceptible. Repletion experiments giving exogenous recombinant murine IFN-gamma were not consistently protective. IFN-gamma may be necessary but not sufficient in host defense against the organism.
D000818:Animals; D002478:Cells, Cultured; D002690:Chlamydia Infections / Q000503:physiopathology*; D002692:Chlamydia trachomatis / Q000254:growth & development; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000502:physiology* / Q000627:therapeutic use; D051379:Mice; D011014:Pneumonia / Q000382:microbiology / Q000503:physiopathology*
D007371:Interferon-gamma