title: Urinary and renal papillary solutes during cyclooxygenase inhibition with ibuprofen.
abstract: We investigated the mechanisms by which prostaglandin synthetase (cyclooxygenase) inhibitors cause antidiuresis and antinatriuresis in anesthetized dogs. Cyclooxygenase inhibition with ibuprofen caused an increased total solute (Na+, K+, and urea) concentration in the renal papilla. Xenon 133 washout studies revealed no change in medullary blood flow. Ibuprofen induced a 147% increase in papillary Na+ concentration, while increasing urea and K+ only 98% and 35%, respectively, suggesting that a Na+ reabsorption mechanism rather than decreased papillary blood flow was responsible for a majority of the increased papillary solute concentration. A decrease in the excretion of Na+, but not of K+ or urea, in treated dogs further implies increased Na+ reabsorption. Thus, it appears that cyclooxygenase inhibition increases papillary solute concentration primarily by increasing Na+ transport into the papilla.
mesh_terms: D000818:Animals; D001692:Biological Transport; D016861:Cyclooxygenase Inhibitors; D004285:Dogs; D004573:Electrolytes / Q000652:urine; D007052:Ibuprofen / Q000494:pharmacology*; D007679:Kidney Medulla / Q000098:blood supply / Q000378:metabolism*; D011188:Potassium / Q000097:blood / Q000378:metabolism; D012039:Regional Blood Flow; D012964:Sodium / Q000097:blood / Q000378:metabolism; D014508:Urea / Q000097:blood / Q000378:metabolism; D014980:Xenon Radioisotopes
chemical_list: D016861:Cyclooxygenase Inhibitors; D004573:Electrolytes; D014980:Xenon Radioisotopes; D014508:Urea; D012964:Sodium; D011188:Potassium; D007052:Ibuprofen