Bifunctional roles of catecholamines in the development of amygdala kindling demonstrated by continuous intra-amygdala infusion of 6-hydroxydopamine.
Details of seizure stage progression in amygdala kindling were studied in the cat under local denervation of catecholamine input to the amygdala. A chemitrode was used for both electrical stimulation and continuous infusion of 6-hydroxydopamine. The extent of denervation was confirmed by fluorescence histochemistry. The result has indicated that catecholamine afferents to the amygdala exert biphasic roles in normal kindling: inhibitory in the early local and late generalized seizure stages, whereas facilitatory in the intermediate stage.
D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D016627:Oxidopamine
D006892:Hydroxydopamines; D016627:Oxidopamine