The effect of weight loss, operation and parenteral nutrition on fat clearance in patients with colorectal cancer.
1. Fractional fat clearance rate (K2) in 21 patients with colorectal cancer was studied using the intravenous fat tolerance test. 2. K2 showed a negative correlation with weight change (r = -0.736, P less than 0.001) with the tumour in situ. 3. Fourteen patients were retested 12 weeks after curative resection of their tumours. Eight of the fourteen patients had raised K2 values pre-operatively; in all these the K2 values were reduced post-operatively (pre-operative median 3.94%/min, range 2.63-7.20%/min, post-operative median 2.31%/min, range 1.57-5.36%/min, P less than 0.01 by Wilcoxon's signed rank test). A high pre-operative K2 value was associated with a large reduction in K2 post-operatively (r = -0.844, P less than 0.001). 4. Seven patients with relatively high K2 values received a pre-operative course of intravenous nutrition after which K2 values were significantly reduced (pre-feeding median 7.20%/min, range 4.72-12.12%/min, post-feeding median 4.44%/min, range 2.17-6.83%/min, P less than 0.05).
D000368:Aged; D001835:Body Weight; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D008055:Lipids / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010288:Parenteral Nutrition; D012004:Rectal Neoplasms / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery
D008055:Lipids