title: [Extraosseous calcification in juvenile dermatomyositis. The ineffectiveness of EHDP].
abstract: A now 20-year-old man was first diagnosed as having dermatomyositis when aged 12 years. At that time he had muscular weakness and heart failure followed a year later by heterotopic calcifications. For over seven years he was treated with corticoids, at times also with azathioprine or methotrexate. Nonetheless the calcifications progressed. Because of the extensive calcifications, predominantly of the extremities, he is severely disabled and has been confined to a wheel-chair. For one year he was treated with EHDP (1-hydroxyethylidenediphosphonate), up to 16 mg/dl per day. In addition he received prednisolone (10 mg/d) and azathioprine (100 mg/d). But radiologically there has been further slight progression of the calcifications, indicating that EHDP has been ineffective in this patient.
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D002908:Chronic Disease; D003882:Dermatomyositis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D012968:Etidronic Acid / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011859:Radiography; D013997:Time Factors
chemical_list: D012968:Etidronic Acid
vernacular_title: Extraossäre Calcifikationen bei juveniler Dermatomyositis. Unwirksamkeit von EHDP.