[Effects of tissue-type plasminogen activator from a culture of calf kidney cells on hemostasis and fibrinolysis in experimental nephritis].
The plasminogen activator 960 IU/mg protein activity isolated from cultured fluid of the calf kidney cells was introduced to albino rats (180-200 g) with experimental Heynmann nephritis every day during 4 days. Nephritis caused activation of haemostasis and inhibition of fibrinolysis in the blood. There was increased excretion of the fibrin, fibrinogen degradation products in urine as a results of the local fibrin deposition in diseased kidneys. The fibrinolytic activity of the cortical zone of kidney was markedly decreased. The plasminogen activator, infused to experimental animals, resulted in normalization of the altered indexes.
D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D005337:Fibrin / Q000652:urine; D005338:Fibrin Fibrinogen Degradation Products / Q000652:urine; D005342:Fibrinolysis / Q000187:drug effects*; D006487:Hemostasis / Q000187:drug effects*; D007668:Kidney / Q000032:analysis; D008297:Male; D009393:Nephritis / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D051381:Rats; D010959:Tissue Plasminogen Activator / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use
D005338:Fibrin Fibrinogen Degradation Products; D005337:Fibrin; D010959:Tissue Plasminogen Activator
Vliianie aktivatora plazminogena tkanevo tipa iz kul'tury kletok pochki telenka na gemostaz i fibrinoliz pri éksperimental'nom nefrite.