A new immunomodulator, FR-900490.
FR-900490 is a new type of immunoactive substance produced by a fungus Discosia sp. F-11809. The colony forming units in culture (cfu-c) in bone marrow cells, which were suppressed by immunosuppressive factor obtained from the serum of sarcoma 180 tumor bearing mouse, was restored to normal level by the addition of FR-900490 in vitro. Furthermore, in mitomycin C (MMC)-treated mice the subsequent administration of FR-900490 caused a significant increase of cfu-c in bone marrow cells depressed by MMC.
D000276:Adjuvants, Immunologic / Q000302:isolation & purification*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification; D001853:Bone Marrow / Q000187:drug effects; D003114:Colony-Forming Units Assay; D005260:Female; D066298:In Vitro Techniques; D051379:Mice; D008813:Mice, Inbred ICR; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D010455:Peptides / Q000302:isolation & purification* / Q000494:pharmacology; D012510:Sarcoma 180 / Q000276:immunology; D013234:Stem Cells / Q000187:drug effects
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D008937:Mitomycins; D010455:Peptides; C057553:FR 900490; D016685:Mitomycin