Diabetes mellitus as a hypercoagulable state: its relationship with fibrin fragments and vascular damage.
Haemostatic variables were assessed in 43 patients, 28 insulin-dependent and 15 non insulin-dependent. Maximum aggregation by low concentrations of adenosine diphosphate (ADP) or arachidonic acid and elevated plasma concentrations of TxB2, Factor VIII, vWF:Ag, RCoF and fibronectin (Fnct) indicated a hypercoagulable state. The manifestation of vasculopathy was associated with elevated concentrations of RCoF, Fnct, Hbalc, cholesterol and triglycerides, while impaired fibrinolysis was demonstrated by decreased t-PA levels and the absence of crosslinked fibrin degradation products (XL-FDP).
D000293:Adolescent; D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D003925:Diabetic Angiopathies / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D005353:Fibronectins / Q000097:blood; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D013929:Thromboxane B2 / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000097:blood
D005338:Fibrin Fibrinogen Degradation Products; D005353:Fibronectins; D013929:Thromboxane B2; D010959:Tissue Plasminogen Activator