Bacteriology of odontogenic apical periodontitis and effect of penicillin treatment.
The microbiology and treatment of apical periodontitis was studied in 62 patients, followed-up for 1 year. The clinical treatment and the radiological technique were standardized. One third of the patients received no systemic antibiotics, one third received phenoxymethylpenicillin for 1 week, and one third for 3 months. On the average, 0-2 facultatively anaerobic and 4-6 anaerobic bacteria were isolated from periapical infections. The genera Bacteroides and Fusobacterium in addition to anaerobic gram-positive cocci were found most frequently. Minimum inhibitory concentrations of benzylpenicillin against 269 strains were tested. 12 strains were resistant at the concentration 2.4 micrograms/ml, including 4 strains of Fusobacterium sp. All patients were free of symptoms 1 month after the admission. Only 1 patient failed to show any progress in radiological healing. No differences between the groups in relation to penicillin therapy were found.
D000328:Adult; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification*; D001421:Bacteria, Anaerobic / Q000187:drug effects / Q000302:isolation & purification*; D001424:Bacterial Infections; D005260:Female; D006801:Humans; D008297:Male; D010400:Penicillin G / Q000494:pharmacology; D010404:Penicillin V / Q000627:therapeutic use*; D010485:Periapical Periodontitis / Q000188:drug therapy / Q000382:microbiology*; D013997:Time Factors
D010400:Penicillin G; D010404:Penicillin V