title: [Lysine acetyl salicylate. Clinical contribution and preliminary data].
abstract: In the general study of antipyretic products for children prone to febrile convulsions, the authors describe the results obtained administering, the rectal route, three different doses of lysine acetylsalicylate (20-30-40 mg/kg/b.w.) to 53 children with fever. The lower dose was often inadequate in these patients, who need a quick reduction of body temperature below 38 degrees C. The two higher doses were useful both in clinical and in statistical terms, without relevant differences between groups. A statistically significant inverse correlation between blood levels of salicylates and temperature was also shown. No undesirable side effects were observed. The authors conclude that ASL, by rectal route, has to be considered a drug of choice for this indication.
mesh_terms: D000285:Administration, Rectal; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000627:therapeutic use; D001241:Aspirin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001831:Body Temperature; D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008239:Lysine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate
vernacular_title: L'acetilsalicilato di lisina per via rettale. Contributo clinico e dati preliminary.