The Drosophila wing test: a comparison of the sensitivity of different strains.
A range of 5 chemical mutagens were tested in the Drosophila wing test using 2 different strains and carrying out the experiments in parallel under standardised conditions. The mutagens chosen for the study were the 2 alkylating agents MMS and ENU and the anti-cancer drugs methotrexate, cytosine-arabinoside and adriamycin. As a result of the different genetic backgrounds there was a marked variation in the response of the 2 strains to the mutagens.
D000477:Alkylating Agents / Q000494:pharmacology; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics*; D007364:Intercalating Agents / Q000494:pharmacology; D009152:Mutagenicity Tests / Q000592:standards*; D009154:Mutation / Q000187:drug effects*; D011995:Recombination, Genetic / Q000187:drug effects; D013045:Species Specificity
D000477:Alkylating Agents; D000964:Antimetabolites, Antineoplastic; D007364:Intercalating Agents