title: Growth and metabolism of mannitol by strains of Saccharomyces cerevisiae.
abstract: Of 40 polyploid strains of Saccharomyces cerevisiae screened for growth on D-mannitol (5%, w/v), half grew well (5-20 mg dry biomass ml-1). Certain of these strains were unable to grow on low concentrations of mannitol (1-2%, w/v) and others, initially unable to grow on mannitol, exhibited long-term adaptation to growth. An NAD+-dependent D-mannitol dehydrogenase (EC 1.1.1.67) was detected in mannitol-grown yeast. Growth was dependent on mitochondrial function and was obligately aerobic. Measurement of products of metabolism and respiratory activity indicated that growth on mannitol allows catabolite derepression.
mesh_terms: D000693:Anaerobiosis; D003470:Culture Media; D008353:Mannitol / Q000378:metabolism*; D010101:Oxygen Consumption; D012441:Saccharomyces cerevisiae / Q000254:growth & development*; D013012:Sorbitol / Q000378:metabolism
chemical_list: D003470:Culture Media; D008353:Mannitol; D013012:Sorbitol