Effect of alloxan diabetes and adrenalectomy on carrageenin-induced pleurisy in the rat.
1. The effect of alloxan diabetes and adrenalectomy on the acute inflammatory response was investigated in rats using the carrageenin-induced pleurisy model. 2. Diabetic rats had reduced exudate volume (-85%) and inflammatory cell accumulation (-50%), especially polymorphonuclear leucocytes (-60%) in the pleural cavity 24 h after stimulation in relation to control values. Subcutaneous insulin administration 2 h after the inflammatory stimulus restored these parameters to normal levels. In contrast, all three measures of the response were potentiated 1.5 to 4-fold in adrenalectomized animals. 3. Results obtained by other investigators using different experimental models point to a possible pro-inflammatory function of insulin for the vascular component of inflammation. The present data show that insulin also has a significant effect on the cellular component of inflammation, especially the polymorphonuclear one, by increasing its accumulation at the affected site.
D000210:Acute-Phase Reaction / Q000503:physiopathology*; D000315:Adrenalectomy; D000496:Alloxan; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000187:drug effects; D007249:Inflammation / Q000503:physiopathology*; D007328:Insulin / Q000494:pharmacology; D007958:Leukocyte Count; D008297:Male; D010998:Pleurisy / Q000503:physiopathology*; D051381:Rats
D007328:Insulin; D000496:Alloxan; D002351:Carrageenan