[Induction of unstable mutations in Drosophila melanogaster by microinjection of DNA from oncogenic viruses into the embryonic polar plasma. III. Genetic instability in the absence of an intact P-element].
DNA of simian adenovirus Sa7 injected into polar plasma of early Drosophila melanogaster y1snw*; bw; st stock embryos induced one to three unstable visible X-linked mutations in the absence of intact P-element. Numerous mutational events (reversions, new mutations) occur only in four precisely destabilized by the Sa7 DNA loci of X-chromosome and take place during 4-5 generations; in the next generations the level of instability decreased. At the same time, Sa7 DNA induced reversions and new allelic mutations in the snw mutant locus, without exogenous intact P-element.
D000261:Adenoviruses, Simian / Q000235:genetics; D000483:Alleles; D000818:Animals; D004279:DNA, Viral / Q000008:administration & dosage / Q000235:genetics*; D004331:Drosophila melanogaster; D004625:Embryo, Nonmammalian; D005786:Gene Expression Regulation; D009154:Mutation; D009858:Oncogenic Viruses / Q000235:genetics*; D014960:X Chromosome / Q000648:ultrastructure
D004279:DNA, Viral
Induktsiia nestabil'nykh mutatsiĭ u Drosophila melanogaster mikroin''ektsieĭ DNK onkogennykh virusov v poliarnuiu plazmu émbrionov. Soobshchenie III. Geneticheskaia nestabil'nost' v otsutstvie polnotsennogo P-élementa.