title: [Basal and gonadotropin releasing hormone-stimulated gonadotropin secretion in patients with chronic uremia].
abstract: In 11 patients with chronic uremia both the basal and stimulated levels of LH and FSH in serum were determined by RIA. After renal transplantation the investigations were repeated in 2 cases. The basal levels of LH were unphysiologically increased whereas FSH was found in the normal range. The stimulation of LH by GnRH was adequate in 6 patients and in 5 there was no response. As a result of renal transplantation there was a drop of LH in serum. It is supposed that the unphysiological increase of LH in patients with chronic uremia is the cause for the disturbances of the menstrual cycle.
mesh_terms: D000328:Adult; D003404:Creatinine / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D016030:Kidney Transplantation; D007986:Luteinizing Hormone / Q000097:blood*; D008875:Middle Aged; D010906:Pituitary Hormone-Releasing Hormones; D011183:Postoperative Complications / Q000097:blood; D014511:Uremia / Q000097:blood*
chemical_list: D010906:Pituitary Hormone-Releasing Hormones; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003404:Creatinine
vernacular_title: Basale und Gonadotropin-Releasinghormon stimulierte Gonadotropinsekretion bei Patientinnen mit chronischer Urämie.