Inhibition of in vitro angiogenesis by lymphotoxin and interferon-gamma.
The effects of lymphotoxin (LT) and interferon (IFN)-gamma on the capillary formation was examined using an in vitro angiogenesis model system. Both LT and IFN-gamma inhibited the capillary formation in a dose dependent manner. To elucidate the mode of action, effects of the lymphokines on endothelial and myofibroblastic cells were studied. We found that the lymphokines inhibited not only the growth of endothelial cells but also the production of collagen by myofibroblastic cells. These results suggest that the pleiotropic effects of the lymphokines on different types of cells might result in the inhibition of the capillary formation.
D043925:Angiogenesis Inducing Agents / Q000037:antagonists & inhibitors*; D020533:Angiogenesis Inhibitors; D000818:Animals; D002196:Capillaries / Q000502:physiology; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D003094:Collagen / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D006131:Growth Inhibitors; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008233:Lymphotoxin-alpha / Q000494:pharmacology*; D011506:Proteins / Q000494:pharmacology*; D051381:Rats
D043925:Angiogenesis Inducing Agents; D020533:Angiogenesis Inhibitors; D006131:Growth Inhibitors; D008233:Lymphotoxin-alpha; D011506:Proteins; D007371:Interferon-gamma; D003094:Collagen