title: [Status of pancreatic organ and pancreatic islet cell transplantation].
abstract: The results of allogeneic clinical islet cell transplantation continue to be rather disappointing. However, results of clinical pancreatic transplantation in Type-I-diabetes are still improving: some centres (incl. the Munich centre) have reported a 1-year-graft survival rate of more than 70%. In 60-65% of successfully transplanted patients a normalisation of glucose tolerance can be achieved. There is accumulating evidence suggesting that successful pancreatic transplantation exerts a curative effect in Type I diabetes mellitus: Long term investigations have shown a subjective and objective improvement of diabetic retinopathy, nephropathy, polyneuropathy and peripheral microangiopathy.
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000601:surgery*; D006801:Humans; D007328:Insulin / Q000097:blood; D016381:Islets of Langerhans Transplantation; D016035:Pancreas Transplantation; D011379:Prognosis
chemical_list: D001786:Blood Glucose; D007328:Insulin
vernacular_title: Stand der Pankreasorgan- und Pankreasinseltransplantation.