Immunosuppression of collagen-induced arthritis in mice with an anti-IL-2 receptor antibody.
The use of an anti-IL-2R antibody, 7D4, was investigated in vivo in the suppression of collagen-induced arthritis in mice. 7D4 was shown to reduce the incidence of arthritis in a group of mice immunized with type II collagen as compared with a group similarly immunized with collagen and treated with a control isotype matched anti-Forsmann antibody. 7D4 was also shown to reduce the severity of arthritis in the treated mice as compared to the mice in the group treated with the control antibody. Anti-IL-2R antibodies may be useful in the treatment of autoimmune diseases by selectively suppressing activated T cells.
D000818:Animals; D000910:Antibodies, Heterophile / Q000096:biosynthesis; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D001323:Autoantibodies / Q000096:biosynthesis; D003094:Collagen / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000209:etiology; D007075:Immunoglobulin M / Q000096:biosynthesis; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007376:Interleukin-2 / Q000378:metabolism*; D051379:Mice; D008811:Mice, Inbred DBA; D051381:Rats; D011971:Receptors, Immunologic / Q000276:immunology*; D015375:Receptors, Interleukin-2
D000910:Antibodies, Heterophile; D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D003094:Collagen