title: The effect of cochleostomy on the development of endolymphatic hydrops--morphologic changes in the rabbit cochlea.
abstract: The present study was designed to examine the effects of cochleostomy on the development of endolymphatic hydrops in the rabbit. Fistulization of the cochlear partition and simultaneous obstruction of the endolymphatic duct was performed in one group of animals (n = 13). Rabbits in two other groups underwent either cochleostomy (n = 6) or endolymphatic duct obstruction (n = 6) alone. Animals were terminated at 1-, 4-, and 6-week intervals and the cochleas were examined with the light microscope to document the presence or absence of hydrops, or were evaluated with the scanning electron microscope to assess sensory-cell damage. Hydrops was observed in 67% of the animals in the combined duct-obstruction/cochleostomy group, in 100% of the duct-obstruction alone group, and in 0% of the cochleostomy alone group. Widespread sensory-cell degeneration was observed with the scanning electron microscope in the combined and the cochleostomy alone groups.
mesh_terms: D000818:Animals; D003051:Cochlea / Q000601:surgery*; D004487:Edema / Q000503:physiopathology*; D004710:Endolymph / Q000502:physiology*; D004711:Endolymphatic Duct / Q000503:physiopathology; D006198:Hair Cells, Auditory / Q000648:ultrastructure; D007761:Labyrinthine Fluids / Q000502:physiology*; D008855:Microscopy, Electron, Scanning; D009925:Organ of Corti / Q000648:ultrastructure; D011817:Rabbits