Clinical trial with muzolimine in healthy and hypertensive subjects: new vistas on the drug action.
The mechanism of muzolimine (3-amino-1-[3,4-dichloro-alpha-methyl-benzyl]-2 pyrazolin-5-one) action is still not completely defined. The identified site of action is the Henle loop, similarly to furosemide which acts also by mediating renal prostaglandin synthesis. The aim of the present study was to evaluate the early effects of muzolimine (30 mg per os) on renal function and prostaglandin urinary excretion in healthy controls and hypertensive subjects. Urinary flow reached the peak values by the third hour after the drug and a diuretic effect not directly dependent on glomerular filtration was observed, especially in hypertensive patients. In these cases the diuresis increased also due to a low glomerular filtration rate and tubular phenomena were more evident than in controls: an increasing Na+ tubular excretion and a parallel decreasing % Na+ reabsorption. Blood pressure was not significantly influenced by muzolimine in healthy subjects, while it returned to normal values in the hypertensive group. A cyclooxigenase inhibitor, lysine acetylsalicylate (1 g i.m.) administered 10 minutes after muzolimine, was not able to modify the parameters under consideration. Therefore a mediation by prostaglandins on the diuretic and antihypertensive effects of the drug under study may probably be excluded.
D000368:Aged; D001241:Aspirin / Q000031:analogs & derivatives / Q000627:therapeutic use; D015232:Dinoprostone; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism*; D008239:Lysine / Q000031:analogs & derivatives / Q000627:therapeutic use; D008875:Middle Aged; D009156:Muzolimine / Q000494:pharmacology* / Q000627:therapeutic use; D011458:Prostaglandins E / Q000652:urine; D011720:Pyrazoles / Q000494:pharmacology*
D011458:Prostaglandins E; D011720:Pyrazoles; D009156:Muzolimine; D008239:Lysine; D015232:Dinoprostone; D001241:Aspirin; C010395:acetylsalicylic acid lysinate