Reaction of dendritic melanocytes in vitiligo to the substrates of tyrosine metabolism.
Frozen sections of vitiliginous skin were treated with the substrates involved in melanogenesis and adrenergic activity to study the effect of changing chemical milieu on the biphasic dendritic melanocytes. The substrates used are tyrosine, DOPA, tyrosine + DOPA, dopamine, adrenalin and cupric ions. It was observed that tyrosine when used alone has a weak melanogenic reaction while DOPA and tyrosine + DOPA show a prominent activity. Adrenalin and dopamine inhibit the neural limb and enhance melanogenesis. Cupric ions on the other hand enhance the neural limb and inhibit melanogenesis. These changes are not evident in the non-dendritic melanocytes. Thus the highly dendritic melanocytes are at a lower state of differentiation. These biphasic cells are more sensitive to changes in the chemical milieu.
D003300:Copper / Q000378:metabolism; D019327:Copper Sulfate; D003713:Dendritic Cells / Q000201:enzymology*; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D006801:Humans; D008544:Melanocytes / Q000201:enzymology*; D014442:Monophenol Monooxygenase / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D010084:Oxidation-Reduction; D013379:Substrate Specificity; D014443:Tyrosine / Q000378:metabolism*; D014820:Vitiligo / Q000201:enzymology*
D014443:Tyrosine; D004295:Dihydroxyphenylalanine; D003300:Copper; D014442:Monophenol Monooxygenase; D019327:Copper Sulfate; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine