[Effect of correcting liver function on the development of DMBA-induced mammary gland tumors and the metabolism of sex steroid hormones in rats].
The tumours of mammary glands in Wistar rat females were induced by threefold intravenous administration of 7,12-dimethylbenz (a) anthracene (DMBA). The application of pharmacological preparations contributing to the liver function correction (PCLF) in the process of carcinogenesis and during the surgical treatment of mammary tumours leads to prolongation of the first tumour latent period after DMBA administration and of recurrent tumours after the operation. The lowering of the frequency, multiplicity and the rate of mammary tumours growth were also observed. The use of PCLF exerted a normalizing effect on the level of sex steroid hormones in rats.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000735:Androstenedione / Q000097:blood; D000818:Animals; D004958:Estradiol / Q000097:blood; D004964:Estriol / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000502:physiology*; D008325:Mammary Neoplasms, Experimental / Q000097:blood / Q000139:chemically induced* / Q000601:surgery; D051381:Rats; D013739:Testosterone / Q000097:blood
D012739:Gonadal Steroid Hormones; D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol; D015127:9,10-Dimethyl-1,2-benzanthracene; D004964:Estriol
Vliianie korrektsii funktsii pecheni na razvitie opukholeĭ molochnoĭ zhelezy, indutsirovannykh DMBA, i obmen polovykh steroidnykh gormonov u krys.