Central glucagon antagonizes morphine- and stress-induced antinociception in the mouse.
Previously, we have demonstrated that glucagon antagonizes morphine-induced antinociception in the rat (Malcolm et al. 1985). In the present studies we have shown that central injection of glucagon antagonizes morphine- and stress-induced antinociception in the mouse. Since stress-induced antinociception is mediated by the activation of endogenous opioid systems, these findings provide the first evidence for glucagon's ability to antagonize endogenous opioid actions.
D000698:Analgesia; D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D005934:Glucagon / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009020:Morphine / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*
D009020:Morphine; D005934:Glucagon