title: Different sensitivities to agonist of muscarinic acetylcholine receptor subtypes.
abstract: Muscarinic acetylcholine receptor (mAChR) III expressed in Xenopus oocytes, like mAChR I, mediates activation of a Ca2+-dependent Cl- current, whereas mAChR IV, like mAChR II, principally induces activation of Na+ and K+ currents in a Ca2+-independent manner. mAChR III has a sensitivity to agonist of about one order of magnitude higher than that of mAChR I in mediating the Ca2+-dependent current response in Xenopus oocytes and in stimulating phosphoinositide hydrolysis in NG108-15 neuroblastoma-glioma hybrid cells. The agonist-binding affinity of mAChR III is also about one order of magnitude higher than that of mAChR I.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000502:physiology; D002217:Carbachol / Q000494:pharmacology; D004274:DNA, Recombinant; D004305:Dose-Response Relationship, Drug; D004533:Egtazic Acid / Q000494:pharmacology; D004553:Electric Conductivity; D007295:Inositol Phosphates / Q000378:metabolism; D008564:Membrane Potentials; D008845:Microinjections; D009865:Oocytes; D011813:Quinuclidinyl Benzilate / Q000494:pharmacology; D051381:Rats; D011976:Receptors, Muscarinic / Q000145:classification / Q000502:physiology*; D013552:Swine; D014982:Xenopus laevis
chemical_list: D004274:DNA, Recombinant; D007295:Inositol Phosphates; D011976:Receptors, Muscarinic; D004533:Egtazic Acid; D011813:Quinuclidinyl Benzilate; D002217:Carbachol; D000109:Acetylcholine; D002118:Calcium