Successful renal transplantation with cadaveric donor kidneys of extremely prolonged cold ischaemic time.
At 3, 6 and 12 months, there was no difference in renal function and survival between a group of renal transplant recipients who received cadaveric donor kidneys of extremely prolonged cold ischaemic time (group median 60 h; range 35-82 h), compared to a group who received cadaveric donor kidneys of shorter cold ischaemic time (group median 20 h; range 6-44 h). The prolonged cold ischaemic time group had a higher incidence of primary non-function, but the duration of primary non-function was not different between the two groups. The prolonged cold ischaemic time group had significantly fewer episodes of rejection. Despite the increased incidence of primary non-function, this study shows that it is safe to use low-dose cyclosporin A in kidney grafts with an extremely prolonged cold ischaemic time.
D000293:Adolescent; D000328:Adult; D002102:Cadaver; D003524:Cyclosporins / Q000627:therapeutic use; D005615:Freezing; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D006982:Hypertonic Solutions / Q000627:therapeutic use; D016030:Kidney Transplantation; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods*; D013997:Time Factors
C024102:Collins' solution; D003524:Cyclosporins; D006982:Hypertonic Solutions