The endogenous tripeptide Tyr-Gly-Gly as an extracellular metabolite of enkephalins in rat brain: origin and metabolism.
The tripeptide Tyr-Gly-Gly (YGG) was established as an endogenous constituent in rat brain. Its origin from enkephalin neurons is suggested by its regional distribution paralleling that of (Met5)-enkephalin (YGGFM), its decrease following kainate-induced ablation of the striato-pallidal neurons and its enhanced formation following depolarization of pallidal slices. Enkephalinase (EC 3.4.24.11) is selectively responsible for endogenous YGG formation in vitro and in vivo.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004745:Enkephalins / Q000378:metabolism*; D005917:Globus Pallidus / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009842:Oligopeptides / Q000302:isolation & purification / Q000378:metabolism*; D009928:Organ Specificity; D011699:Putamen / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D004745:Enkephalins; D009842:Oligopeptides; C044757:tyrosyl-glycyl-glycine