(+)-Naloxone: antagonism of pentobarbital-induced narcosis.
Intracerebroventricular injection of (+)-naloxone shortened pentobarbital-induced sleeping times in rats. It does not appear that opiate receptors regulate the duration of narcosis.
D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D007276:Injections, Intraventricular; D008297:Male; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D010424:Pentobarbital / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects*
D009270:Naloxone; D010424:Pentobarbital