title: Ultra-high-frequency jet ventilation in a bronchopleural fistula model.
abstract: High-frequency ventilation techniques have been demonstrated to be useful in decreasing gas loss from bronchopleural fistulas. We performed the present study to evaluate the impact of a new jet ventilator design and ventilatory frequency on hemodynamics, gas exchange, and bronchialstump gas flow in an animal model of bronchopleural fistula. Ten pigs underwent a right-sided thoracotomy and right-sided upper pulmonary lobectomy with cannulation of the upper lobe bronchus for measurement of bronchial fistula flow rate. Animals underwent a random sequence of conventional ventilation (12 to 20 breaths per minute), conventional high-frequency jet ventilation (120 breaths per minute), and ultra-high-frequency jet ventilation (UHFJV; 450 breaths per minute). Hemodynamic measurements were similar in the three ventilatory modes, but oxygenation was best with UHFJV. Bronchial fistula flow was lowest with UHFJV and greatest with conventional ventilation. Ultra-high-frequency jet ventilation demonstrated superior oxygen loading, adequate carbon dioxide elimination, and the least flow through the fistula, suggesting that both ventilator design and frequency are important therapeutic variables in the management of major airway disruption.
mesh_terms: D000818:Animals; D001980:Bronchi / Q000503:physiopathology; D001983:Bronchial Fistula / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D002245:Carbon Dioxide / Q000097:blood; D005402:Fistula / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D006439:Hemodynamics; D006611:High-Frequency Jet Ventilation; D010100:Oxygen / Q000097:blood; D010995:Pleural Diseases / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D012119:Respiration; D013552:Swine
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen