IgM antitrophoblast antibodies in a patient with a pregnancy-associated lupuslike disorder, vasculitis, and recurrent intrauterine fetal demise.
We describe herein circulating IgM antitrophoblast antibodies in a patient with recurrent pregnancy-associated vasculitis and intrauterine fetal demise. The patient also exhibited a lupus anticoagulant. Direct and indirect immunofluorescence studies were carried out with the patient's placenta, normal placentas, the patient's serum, and normal serum controls. The antitrophoblast antibodies may have contributed further to the risk of intrauterine death, already known to be associated with lupus anticoagulants. More information about the frequency of such antibodies is desirable and could be obtained in similar cases by the methods discussed.
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology; D003176:Complement C3 / Q000032:analysis; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D016682:Lupus Coagulation Inhibitor; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology* / Q000473:pathology; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology* / Q000473:pathology; D011249:Pregnancy Complications, Cardiovascular / Q000473:pathology; D012008:Recurrence; D012867:Skin / Q000098:blood supply / Q000473:pathology; D014327:Trophoblasts / Q000276:immunology*; D014657:Vasculitis / Q000150:complications / Q000276:immunology* / Q000473:pathology
D001323:Autoantibodies; D001779:Blood Coagulation Factors; D003176:Complement C3; D007075:Immunoglobulin M; D016682:Lupus Coagulation Inhibitor