[Lithium-induced lesions in the rat retina--potentiation by light].
The treatment of manic-depressive patients with lithium salts is a widespread procedure. Ocular side effects of this therapy comprise changes in electrophysiological and psychophysical parameters. Photochemical damage to the human and animal retina is a widely recognized and investigated phenomenon. The present paper describes lithium-induced changes in the albino rat retina on a morphological and biochemical level that are significantly enhanced by acute light exposure in an intensity-dependent manner. Preliminary biochemical data reveal an increase in phosphatidylinositol metabolites. As a clinical consequence of the study the authors advocate careful ophthalmological examination of chronically lithium-treated patients, especially those suffering from retinal degeneration or who are exposed to light of higher than normal intensity.
D000818:Animals; D001669:Biochemical Phenomena; D001671:Biochemistry; D008027:Light / Q000009:adverse effects*; D008094:Lithium / Q000009:adverse effects* / Q000378:metabolism; D016651:Lithium Carbonate; D010716:Phosphatidylinositols / Q000032:analysis; D010743:Phospholipids / Q000378:metabolism; D010786:Photoreceptor Cells / Q000032:analysis; D051381:Rats; D012160:Retina / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
D010716:Phosphatidylinositols; D010743:Phospholipids; D016651:Lithium Carbonate; D008094:Lithium
Lithium-Schäden in der Ratten-Netzhaut--Verstärkung durch Licht.