title: The mycobacterial cell-wall as target for antimycobacterial drugs. I--Synthesis and activity of some diphenylalkylanalogues of mycolic acids.
abstract: Mycolic acids are 2-alkyl-3-hydroxyfatty acids and are essential parts of the peptidoglycan of mycobacteria. Potential antimetabolites were prepared by substituting a longchain alkylgroup by a diphenylmethylfunction. 3-Oxo esters and 3-hydroxy esters and acids were prepared. The 3-oxo esters showed a slight activity against M. tuberculosis and some atypical mycobacteria.
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002473:Cell Wall / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects / Q000648:ultrastructure*; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009171:Mycolic Acids / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D009171:Mycolic Acids