title: Mathematical and biostatistical methods for designing and analyzing complex chemical interactions.
abstract: In this presentation, statistical methods for designing and analyzing experiments evaluating a mixture of drugs/chemicals are discussed. These methods are promising in that they are not limited by the number of interacting agents in the combination. Several examples are given and a discussion of the results follows.
mesh_terms: D006585:Altretamine / Q000633:toxicity; D000818:Animals; D002945:Cisplatin / Q000633:toxicity; D064420:Drug-Related Side Effects and Adverse Reactions; D005472:Fluorouracil / Q000633:toxicity; D051379:Mice; D008815:Mice, Inbred Strains; D008956:Models, Chemical; D011929:Razoxane; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013223:Statistics as Topic
chemical_list: D011929:Razoxane; D002945:Cisplatin; D006585:Altretamine; D005472:Fluorouracil