title: Experimental transmission of a goat strain of Sarcoptes scabiei to desert sheep and its treatment with ivermectin.
abstract: Desert sheep were experimentally infected with a goat strain of Sarcoptes scabiei, proving that this mite is not completely host specific. More severe lesions were produced on sheep when the mites were applied to lacerated than when applied to scarified or non-scarified areas. Lesions were more pronounced on moistened areas than dry areas and lesions produced on dry scarified areas resembled those produced on non-scarified moistened ones. Skin scrapings from the experimental lesions in the sheep contained numerous mites of all stages, proving the goat mites had become well established and were reproducing actively in the experimental lesions. Severe histopathological changes were observed in skin sections, comprising mainly thick crust formation, mites beneath the keratin and severe degenerative and necrotic changes. Treatment of sheep with ivermectin at a dose rate of 200 micrograms kg-1 body weight produced rapid and excellent cure.
mesh_terms: D000818:Animals; D006041:Goats / Q000469:parasitology*; D007559:Ivermectin / Q000627:therapeutic use*; D008297:Male; D012520:Sarcoptes scabiei / Q000254:growth & development; D012532:Scabies / Q000188:drug therapy / Q000635:transmission / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy / Q000635:transmission*; D012867:Skin / Q000469:parasitology / Q000473:pathology
chemical_list: D007559:Ivermectin