Oxidation of some seleno-diamines by pig kidney diamine oxidase.
The enzymatic deamination of Se-lanthionamine (Se-L), Se-homolanthionamine (Se-HL) and Se-homocystamine (Se-HC) catalyzed by pig kidney diamine oxidase (PKAO) has been studied to collect information about the possible metabolic reactions of selenocompounds in comparison with the sulfur ones. The results indicate that: Se-L, Se-HL and Se-HC are substrates for PKAO. The first product of Se-L, Se-HL and Se-HC oxidative deamination, in analogy with other thio and seleno diamines, may be the cyclized aminoaldehyde. The final product of Se-L, Se-HL and Se-HC degradation are ammonia, elemental selenium and C2 or C3 compounds.
D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism*; D000588:Amines / Q000378:metabolism; D000818:Animals; D007668:Kidney / Q000201:enzymology*; D010084:Oxidation-Reduction; D012643:Selenium / Q000378:metabolism*; D013379:Substrate Specificity; D013552:Swine
D000588:Amines; D006631:Amine Oxidase (Copper-Containing); D012643:Selenium