title: Structural properties of the covalent (+)-anti-BPDE-poly(dG-dC)(dG-dC) complex.
abstract: The structure of the covalent (+)-anti-BPDE-poly(dG-dC) complex can be represented by two preferred orientations of the pyrene moiety; one at about 20 degrees relative to the helix axis and one at about 70 degrees, populated as 4:1. A rapid mobility of the BPDE may allow an exchange between the two orientations. The poly(dG-dC) structure becomes more flexible by (+)-anti-BPDE modification, seen as a shortened persistence length. This complex may be significant as a model for DNA interaction with covalently binding polyaromatic carcinogens.
mesh_terms: D015123:7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; D004101:Dihydroxydihydrobenzopyrenes; D011089:Polydeoxyribonucleotides; D013057:Spectrum Analysis
chemical_list: D004101:Dihydroxydihydrobenzopyrenes; D011089:Polydeoxyribonucleotides; C019530:poly(dC-dG); D015123:7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide