Long-term suppression of a testosterone-producing ovarian tumour by oestrogen/progestogen therapy.
A 44-year-old lady presenting with hirsutism was found to have a testosterone-secreting Leydig cell tumour of the right ovary. Serum testosterone levels were adequately suppressed for 8 years by combined oestrogen/progestogen preparation (Microgynon 30, Schering, West Sussex). The fall in gonadotrophin and testosterone levels during therapy and their rise after stopping therapy suggests that the tumour was gonadotrophin dependent.
D000328:Adult; D004997:Ethinyl Estradiol / Q000627:therapeutic use*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007984:Leydig Cell Tumor / Q000188:drug therapy* / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D009644:Norgestrel / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism*
D009644:Norgestrel; D013739:Testosterone; D004997:Ethinyl Estradiol; D019304:Ethinyl Estradiol-Norgestrel Combination; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone