title: Biologic and instrumentation issues in MR contrast agent research.
abstract: The interaction between magnetic resonance (MR) detectors and MR contrast agents as "dyes" or indicators is important. Indicator-dilution methods can be adapted to dynamic studies with available contrast agents, but the change in MR intensity must quantitatively reflect change in MR contrast agent concentration. Although spatial and temporal resolution may conflict in determining the MRI parameters, examples show that imaging of physiologic function in vivo is feasible. Cost effectiveness also should be studied early.
mesh_terms: D003287:Contrast Media; D003362:Cost-Benefit Analysis; D006801:Humans; D007201:Indicator Dilution Techniques; D008279:Magnetic Resonance Imaging / Q000295:instrumentation
chemical_list: D003287:Contrast Media