Glidobactins A, B and C, new antitumor antibiotics. I. Production, isolation, chemical properties and biological activity.
New antitumor antibiotic glidobactins A, B and C were isolated from the cultured broth of a gliding bacterium, Polyangium brachysporum sp. nov. No. K481-B101. They are novel molecules carrying the common cyclic tripeptide nucleus substituted with different alpha, beta, gamma, delta-unsaturated fatty acids. Glidobactins exhibit broad inhibitory activity against fungi and yeasts, and prolong the life span of mice inoculated with P388 leukemia cells.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005658:Fungi / Q000187:drug effects; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D008239:Lysine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D009231:Myxococcales / Q000378:metabolism; D010456:Peptides, Cyclic; D013055:Spectrophotometry, Infrared
D000903:Antibiotics, Antineoplastic; D010456:Peptides, Cyclic; C057878:glidobactin A; C057879:glidobactin B; C057880:glidobactin C; D008239:Lysine