title: [Effect of calcium-regulating hormones on the secretory activity of basophils of the thyroid and parathyroid glands].
abstract: The purpose of the study was to compare the secretory activity of thyroid and parathyroid mast cell populations during a rise of the level of calcium regulating hormones in the body. 65 rats were divided into 5 equal groups. The animals were given single intraperitoneal injections of the following agents: the 1st group--parathyroid hormone, 5 units per 100 g of body mass; the 2nd group--trilon B, 0.5 ml of 5% solution; the 3rd group--calcitonin, 1.5 units per 100 g of body mass; the 4th group--calcium gluconate, 0.7 ml of 10% solution; the 5th group--distilled water, 0.7 ml; after that the animals were killed with a 12 min. interval. The index of mast cell degranulation was calculated in the thyroid and parathyroid. The administration of PTH and trilon B caused a significant increase in parathyroid mast cell degranulation 36-120 min. after injection whereas secretory activity of thyroid tissue basophils did not change. Mast cell populations of both glands reacted in a similar way to the administration of calcitonin and calcium gluconate expressed in significant enhancement of degranulation 24-84 min. after injection. The results obtained indicated an important role of thyroid and parathyroid tissue basophils in the implementation of inter- and intraorganic regulatory interactions.
mesh_terms: D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D004492:Edetic Acid / Q000494:pharmacology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology*; D010280:Parathyroid Glands / Q000166:cytology / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical; D013961:Thyroid Gland / Q000166:cytology / Q000378:metabolism*
chemical_list: D010281:Parathyroid Hormone; D002116:Calcitonin; D004492:Edetic Acid; D002118:Calcium
vernacular_title: Vliianie kal'tsiĭreguliruiushchikh gormonov na sekretornuiu aktivnost' tkanevykh bazofilov shchitovidnoĭ i okoloshchitovidnykh zhelez.