N-methyl-N-nitrosourea-induced malformations of the temporomandibular joint in rats.
N-methyl-N-nitrosourea given to pregnant rats intraperitoneally produced hypoplasia of the midface, brachygnathia and a wide variety of hypoplasias of the temporomandibular joint in the offspring. The following deformities were also identified: twinning of the condylar process and ankylosis of the joint.
D000014:Abnormalities, Drug-Induced / Q000209:etiology* / Q000473:pathology; D000818:Animals; D000844:Ankylosis / Q000139:chemically induced; D005260:Female; D008335:Mandibular Condyle / Q000002:abnormalities / Q000473:pathology; D008770:Methylnitrosourea; D051381:Rats; D011919:Rats, Inbred Strains; D013704:Temporomandibular Joint / Q000002:abnormalities* / Q000473:pathology; D013705:Temporomandibular Joint Disorders / Q000139:chemically induced*
D008770:Methylnitrosourea