title: [Radiobiological bases of time and dose distribution in radiotherapy].
abstract: After the very rapid perception in the beginning of this century, that a fractionated radiotherapy is favourable on the ground of intracellular recovery, it has lasted for a long time until conceptions have been indicated for the timing of dose distribution. The used formalisms have been based on clinical empiricism. More recent concepts have shown that dose effect relations can be described by a linear-quadratic function of dose not only for cell killing but also for tumour control and radiation effects in tissues. This concept has been discussed. Some examples of fractionated irradiation have been described for which the linear-quadratic dose model gives good results and these can be described by the alpha-/beta-ratio. However, it has been demonstrated that besides intracellular recovery the repopulation of cells has a considerable significance which is considered only to a small degree by the linear-quadratic model. These factors which are very different in individual cases have to be considered in the future.
mesh_terms: D000818:Animals; D002455:Cell Division / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007399:Interphase / Q000528:radiation effects; D007583:Jejunum / Q000528:radiation effects; D007668:Kidney / Q000528:radiation effects; D008168:Lung / Q000528:radiation effects; D008297:Male; D008545:Melanoma / Q000532:radiotherapy; D051379:Mice; D008954:Models, Biological; D011817:Rabbits; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D051381:Rats; D012004:Rectal Neoplasms / Q000532:radiotherapy; D012867:Skin / Q000528:radiation effects; D013116:Spinal Cord / Q000528:radiation effects; D013552:Swine; D013737:Testis / Q000528:radiation effects; D013997:Time Factors
vernacular_title: Einige strahlenbiologische Grundlagen der Zeit- und Dosisverteilung in der Strahlentherapie.