Radiolabeled red cell viability. II. 99mTc and 111In for measuring the viability of heterologous red cells in vivo.
The authors developed a double in vivo crossmatch method using 2 to 3 ml of potential donor blood labeled with either 400 microCi of 99mTc or 30 microCi of 111In-oxine. Data are presented for 19 crossmatches on nine patients, using one blood specimen labeled with 99mTc or two specimens, one labeled with 99mTc and the other with 111In. Normal values are given for standardization purposes. This method appears to have advantages over earlier in vivo crossmatch techniques using 51Cr-labeled RBCs. These advantages include the rapidity with which the in vivo crossmatch may be repeated, the ready availability of 99mTc and 111In-oxine, and the lower radiation absorbed doses with the shorter-lived radionuclides.
D002470:Cell Survival; D004912:Erythrocytes / Q000502:physiology*; D006801:Humans; D007204:Indium; D015125:Oxyquinoline; D011868:Radioisotopes; D013667:Technetium
D011868:Radioisotopes; D007204:Indium; D015125:Oxyquinoline; D013667:Technetium