title: Methodologies for interpretation of short-term test results which may allow reduction in the use of animals in carcinogenicity testing.
abstract: Assessment of the risk to humans posed by chemical substances currently relies primarily on experimental exposure of animals in lifetime feeding studies. Short-term tests for genotoxicity are much less costly and use fewer or no animals, but have not replaced the long-term animal bioassay because their results do not coincide completely. We have developed methodologies for interpretation of short-term tests which improve the usefulness of their results, and may allow them to replace the long-term animal bioassay in some circumstances.
mesh_terms: D000826:Animal Testing Alternatives; D000818:Animals; D015197:Carcinogenicity Tests / Q000379:methods*; D003362:Cost-Benefit Analysis; D003627:Data Interpretation, Statistical; D011237:Predictive Value of Tests; D013045:Species Specificity; D013997:Time Factors