[Dynamics of endogenous bacterial nitrite formation in the stomach. 3. Dependence of nitrate and nitrite concentration on secretion volume].
The nitrate and nitrite concentration of 96 fasting gastric juice samples of young healthy volunteers were analysed. Two different methods have been used to take the gastric juice: 54 secrete samples were taken directly from the stomach, 42 secrete samples were taken after instillation of 500 ml sterile nitrite and nitrate free NaCl solution ("gastric-washing"). It could be shown that the expected high dilution of nitrite and nitrate concentration after gastric washing does not occur. A possible explanation might be that the solubilisation we could formerly observe in a biological pattern leads to a release of ions. This fact is very important for the question of endogen synthesis of cancerogenic N-nitroso compounds, because high nitrite and nitrate concentrations are subjects of interests as precursors of these compounds.
D001419:Bacteria / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009566:Nitrates / Q000032:analysis / Q000378:metabolism*; D009573:Nitrites / Q000032:analysis / Q000378:metabolism*; D013270:Stomach / Q000382:microbiology
D009566:Nitrates; D009573:Nitrites
Dynamik der endogenen bakteriellen Nitritbildung im Magen. 3. Mitteilung: Abhängigkeit der Nitrat- und Nitritkonzentration vom Sekretvolumen.