title: Diet-induced thermogenesis in cafeteria-fed rats: a myth?
abstract: Oxygen consumption (VO2), carbon dioxide production (VCO2), and respiratory quotient were measured in rats given a high-fat cafeteria diet of the type that is said to promote diet-induced thermogenesis. No significant difference in the measurements as compared with controls was found at room temperature, at 5 degrees C, or in animals exposed to cold for several weeks. The result was the same whether open- or closed-circuit methods were used. The stimulatory effect of norepinephrine on the VO2 was identical in each dietary group. These results cast doubt on the alleged identity of diet-induced and nonshivering thermogenesis and may reflect the change in body composition of the animals rather than a primary response to dietary variation.
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D002245:Carbon Dioxide / Q000096:biosynthesis; D003080:Cold Temperature; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D009638:Norepinephrine / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects
chemical_list: D004041:Dietary Fats; D002245:Carbon Dioxide; D009638:Norepinephrine