title: Immunocytochemical studies of the vascular endothelial cells in human Peyer's patches and solitary lymphoid follicles.
abstract: The present immunohistochemical study of human Peyer's patches and solitary lymphoid follicles have revealed that the PCV in these thymus-dependent areas has a specialized endothelium to which T and B lymphocytes generated in these follicles selectively adhere and then penetrate. The PCV endothelium shares antigens with a peripheral monocyte or macrophage subset which is HLA-DR+, OK-M5+ and OK-M1-. The presence of such antigens could be responsible for regulation of the lymphocyte passage through the venules, and for lymphocyte maturation, activation and proliferation during the migration. A possible route used by the lymphocytes traversing the PCV endothelium is discussed.
mesh_terms: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis; D002465:Cell Movement; D004730:Endothelium, Vascular / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007082:Ileum / Q000166:cytology; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008854:Microscopy, Electron; D009000:Monocytes / Q000276:immunology; D010581:Peyer's Patches / Q000166:cytology / Q000276:immunology*; D011971:Receptors, Immunologic / Q000032:analysis; D015375:Receptors, Interleukin-2
chemical_list: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D006684:HLA-DR Antigens; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2