Intestinal permeability to [51Cr]EDTA in children with Crohn's disease and celiac disease.
[51Cr]EDTA was used as a probe molecule to assess intestinal permeability in 7 healthy control adults, 11 control children, 17 children with Crohn's disease, and 6 children with untreated celiac disease. After subjects fasted overnight, 75 kBq/kg (= 2 microCi/kg) 51Cr-labeled EDTA was given by mouth; 24-h urinary excretion of [51 Cr]EDTA was measured and expressed as a percentage of the total oral dose. Mean and SD were as follows: control adults 1.47 +/- 0.62, control children 1.59 +/- 0.55, and patients with Crohn's disease or celiac disease 5.35 +/- 1.94. The difference between control children and patients was statistically significant (p less than 0.001). These results show that intestinal permeability to [51Cr]EDTA is increased among children with active or inactive Crohn's disease affecting small bowel only or small bowel and colon, and with untreated celiac disease. The [51Cr]EDTA permeability test could facilitate the decision to perform more extensive investigations in children suspected of small bowel disease who have atypical or poor clinical and biological symptomatology.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002446:Celiac Disease / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D002860:Chromium Radioisotopes / Q000378:metabolism*; D003424:Crohn Disease / Q000652:urine*; D004492:Edetic Acid / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D010539:Permeability
D002860:Chromium Radioisotopes; D004492:Edetic Acid