[NAAGA and cromoglycate. A comparison in the treatment of seasonal allergic rhinitis].
A multicentre double-blind clinical trial comparing two nasal solutions of naaga (magnesium salt of N-acetyl aspartyl glutamic acid-rhinaaxia) and of disodium cromoglycate (LOMUPREN) has been performed on 91 patients suffering from an acute symptomatic seasonal rhinitis treated for 28 days. Nasal, ocular and bronchial symptoms as well as side effects were recorded by the physician at the control visits and daily by the patient in a diary. Haematological parameters, blood chemistry and serum levels of non specific IgE were also measured. The results show: On the whole, there was no significant difference between groups, neither for the global appreciation of the therapeutic effect as assessed by the physician and the patient, nor for the daily evolution of the symptoms based on the patient's daily notebook. Both treatments were very well tolerated. In a selected population with IgE greater than 150 U/ml, there was a significantly better activity of naaga (p less than 0.05) on the disappearance of the ocular symptoms. The nasal symptoms appeared to improve significantly better in the cromoglycate group (p less than 0.05).
D000293:Adolescent; D002986:Clinical Trials as Topic; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D004151:Dipeptides / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D011897:Random Allocation; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*
D004151:Dipeptides; C027172:isospaglumic acid; D004205:Cromolyn Sodium
NAAGA und Cromoglycat. Ein Vergleich in der Behandlung der saisonalen allergischen Rhinitis.