[Synthesis and pharmacologic study of several spirohydantoins: relation to conformation].
Using two routes starting from cyclanones, it has been possible to prepare two series of spirohydantoins substituted or not on the hydantoin nucleus nitrogen. These compounds exhibited low toxicity on pig lens aldose reductase (except for two compounds). A discussion is given on the steric and geometric requirements for effective enzyme inhibiting activity.
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006827:Hydantoins / Q000138:chemical synthesis* / Q000494:pharmacology; D007908:Lens, Crystalline / Q000201:enzymology*; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*; D013552:Swine
D006827:Hydantoins; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase
Synthèse et approche pharmacologique de quelques spirohydantoines: relation avec la conformation.