Protective factors in posterior urethral valves.
Patients with posterior urethral valves may present with or contract renal insufficiency. High intravesical pressure that is transmitted to the upper urinary tract in utero is a likely contributing cause. We have identified 3 anatomical associations with posterior urethral valves that provide a pressure "pop-off" mechanism resulting in preservation of better renal function: 1) the syndrome of posterior urethral valves, unilateral vesicoureteral reflux and renal dysplasia; 2) large congenital type bladder diverticula and 3) urinary extravasation with or without urinary ascites. Followup of 71 boys with posterior urethral valves was sufficient to permit long-term analysis. Serum creatinine was used as an index of renal function and prognosis. Of the 71 boys 20 (28 per cent) had 1 of the 3 protective mechanisms. Only 1 child (5 per cent) had a serum creatinine greater than 1.0 mg. per cent. Of the remaining 51 boys without a "pop-off" mechanism 20 (39 per cent) had serum creatinine greater than 1.0 mg. per cent and 7 had already progressed to renal dialysis and/or transplantation. The difference in serum creatinine was statistically significant (p less than 0.01). Thus, the syndrome of posterior urethral valves, unilateral vesicoureteral reflux and renal dysplasia; large congenital bladder diverticula and urinary extravasation can serve as a "pop-off" mechanism to buffer high pressures in the urinary tract and to lead to the preservation of better renal function in boys with posterior urethral valves.
D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D004240:Diverticulum / Q000151:congenital*; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000209:etiology*; D008297:Male; D011379:Prognosis; D013577:Syndrome; D013997:Time Factors; D014521:Urethra / Q000002:abnormalities*; D001745:Urinary Bladder Diseases / Q000151:congenital*; D014556:Urine; D014718:Vesico-Ureteral Reflux / Q000150:complications*
D003404:Creatinine