title: Existence of two distinct processes of chromosomal evolution in near-diploid colorectal tumors.
abstract: The comparison of all the karyotypes established in each of 18 near-diploid colorectal tumors made it possible to reconstruct a clonal evolution and to distinguish between early and late chromosomal aberrations. Because no abnormalities were observed in all tumors, and as even the most frequent changes, i.e., monosomy 17p and monosomy 18, may be present in mosaic, no chromosomal change can be regarded as a common primary event in the carcinogenetic process. However, the repeated occurrence of several changes favors the hypothesis of two karyotypic evolutionary processes. In most tumors, monosomy 17p and 18 were found, and the karyotypic evolution involved mainly several additional monosomies due to unbalanced rearrangements or losses that affect, by order of decreasing frequency, chromosomes 1p, 4, 14, 5q, 6q, 2p, and 11q, as well as gains of chromosomes 20, 8q, 13, 17q, and X. In this group of tumors, the mean number of chromosomes remains close to 46. In the other tumors, either only a monosomy 17p or a monosomy 18 was found and the karyotypic evolution involved essentially trisomies, resulting from gains with, by order of decreasing frequency, a preferential involvement of chromosomes 7, 8q, 13, 17q, 20, X, 2p, 5, and 16, the only additional recurrent deletion affecting chromosome 1p. In these tumors, the mean chromosome number is close to 51. Ten out of 11 polyploid sidelines emerged from monosomic-type tumors.
authors.affiliation: Department of Biology, Institut Curie, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Muleris
authors.forename: R J
authors.initials: RJ
authors.lastname: Salmon
authors.forename: B
authors.initials: B
authors.lastname: Dutrillaux
mesh_terms: D002869:Chromosome Aberrations; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology; D004171:Diploidy; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D012004:Rectal Neoplasms / Q000235:genetics* / Q000473:pathology; D013997:Time Factors
chemical_list: D005819:Genetic Markers