Deregulation and overexpression of c-fos proto-oncogene in rat renal cell-lines and primary tumors induced by dimethylnitrosamine.
Rat renal mesenchymal tumors induced by the chemical carcinogen N-dimethylnitrosamine (DMN) and cell-lines derived from kidneys of rats after DMN treatment were found to express abnormal steady state levels of c-fos RNA. This overexpression was not found to arise by gene amplification or rearrangement, but the c-fos gene appeared to be deregulated resulting in increased transcription. The consistent nature of this observation suggests a function for c-fos gene overexpression in tumorigenesis of the rat kidney by DMN.
Shore
S K
SK
Fels Research Institute, Philadelphia, Pennsylvania.
Hard
G C
GC
Magee
P N
PN
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D004128:Dimethylnitrosamine; D005786:Gene Expression Regulation; D007668:Kidney / Q000201:enzymology; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016760:Proto-Oncogene Proteins c-fos; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000235:genetics / Q000302:isolation & purification; D051381:Rats; D014158:Transcription, Genetic
D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D011505:Protein-Tyrosine Kinases; D004128:Dimethylnitrosamine