Malignant angioendotheliomatosis. An angiotropic lymphoma?
A 61-year-old women developed progressive neurologic deficits and died with pneumonia and septicemia. An autopsy demonstrated the characteristic intravascular and focal perivascular infiltrate of malignant angioendotheliomatosis (MAE) throughout the body but concentrated in the central nervous system and skin. Ultrastructurally, the neoplastic cells lacked evidence of endothelial differentiation. Immunohistochemical studies showed focal staining for Factor VIII-related antigen, probably on a nonspecific basis, negative staining for Ulex europaeus I lectin (an endothelial cell marker), and intense staining for leukocyte common antigen. The authors' observations provide evidence that at least some examples of MAE are unusual, angiotropic lymphoid neoplasms.
Wrotnowski
U
U
Mills
S E
SE
Cooper
P H
PH
D000941:Antigens / Q000276:immunology; D001344:Autopsy; D001932:Brain Neoplasms / Q000473:pathology; D005169:Factor VIII / Q000276:immunology; D005260:Female; D006390:Hemangioendothelioma / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D006649:Histocompatibility Antigens / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D037102:Lectins / Q000032:analysis; D017493:Leukocyte Common Antigens; D008223:Lymphoma / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D008875:Middle Aged; D037121:Plant Lectins; D012878:Skin Neoplasms / Q000473:pathology; D013120:Spinal Cord Neoplasms / Q000473:pathology; D014841:von Willebrand Factor
D000941:Antigens; D006649:Histocompatibility Antigens; D037102:Lectins; D037121:Plant Lectins; C036850:Ulex europaeus lectins; D014841:von Willebrand Factor; D005169:Factor VIII; D017493:Leukocyte Common Antigens