Competitive mechanisms of basic peptides inducing transganglionic degenerative atrophy.
In addition to the classical microtubule inhibitors (antimitotic agents), transganglionic degenerative atrophy of central terminals of primary sensory neurons can be induced also by means of applying to a peripheral nerve basic polypeptides (Polymyxin B and Colimycin) and two basic derivatives of glutamic acid that do not exert any microtubule inhibition. This effect is independent of other pharmacological effects (histamine liberation, Ca2+ -binding, etc.) of the applied compounds, and probably it is based on a competitive reaction with nerve growth factor.
Tajti
J
J
Department of Anatomy, Szent-Györgyi Albert Medical University, Szeged, Hungary.
Penke
B
B
Kovács
K
K
Csillik
B
B
D000818:Animals; D001284:Atrophy; D003091:Colistin / Q000633:toxicity; D005260:Female; D005971:Glutamates / Q000633:toxicity; D006632:Histamine / Q000633:toxicity; D008297:Male; D009410:Nerve Degeneration; D009475:Neurons, Afferent / Q000187:drug effects / Q000473:pathology; D010455:Peptides / Q000633:toxicity*; D011112:Polymyxin B / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000187:drug effects / Q000473:pathology*; D013116:Spinal Cord / Q000187:drug effects / Q000473:pathology*
D005971:Glutamates; D010455:Peptides; D006632:Histamine; D011112:Polymyxin B; D003091:Colistin