[Cerebral circulation at rest and following CO2 stimulation in patients with unilateral carotid obstruction].
Using the 16-detector 133Xe-NaCl-technique (Novo Cerebrograph) quantitative measurements of regional cerebral blood flow (rCBF) were performed in 14 patients with unilateral carotis obstruction before and during stimulation with 3% CO2 inhalation. In all patients resting studies did not show any significant differences in hemispheric perfusion. In 11 patients the hemispheric blood flow increased significantly (by more than 6%) during CO2 inhalation on the side without carotis obstruction. The following results were found after 3% CO2-stimulation over the hemisphere with the obstructed carotid artery: 1) rCBF increased significantly on both sides (n = 6) indicating the sufficiency of cerebral collateral circulation; 2) a side-to-side significant difference (n = 4) with the lower perfusion on the pathological side, indicating a decreased or suspended reserve capacity; and 3) bilateral loss of cerebrovascular reactivity (n = 4) as indicator of insufficiency of cerebral collateral circulation. Asymmetry in rCBF or missing cerebrovascular reserve are indications for surgical treatment of the carotis obstruction.
Chatzipanagiotou
T
T
NuklearmedizinischeAbteilung, Kantonsspital, Basel, Schweiz.
Müller-Brand
J
J
Radü
E W
EW
Rem
J
J
Fridrich
R
R
D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000494:pharmacology*; D002340:Carotid Artery Diseases / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013268:Stimulation, Chemical
D002245:Carbon Dioxide
Zerebrale Durchblutung in Ruhe und nach CO2-Stimulation bei Patienten mit einseitiger Karotisobstruktion.