Epithelial restitution in the large intestine of the rat following insult with bile salts.
In situ loops of large bowel of anaesthetised rats were used to observe epithelial restitution following surface desquamation using solutions of bile salts. The treatment induced complete surface desquamation but no disruption of the basal lamina. There was evidence of, cell migration at 30 min, and a complete surface epithelium two h post treatment. Neither a continuous contact between migrating cells and the basal lamina, nor a complete covering of secreted mucus, appeared necessary for epithelial restitution to occur.
Waller
D A
DA
Department of Human Morphology, Queen's Medical Centre, University of Nottingham, United Kingdom.
Thomas
N W
NW
Self
T J
TJ
D000818:Animals; D001647:Bile Acids and Salts / Q000633:toxicity*; D004848:Epithelium / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D007420:Intestine, Large / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains
D001647:Bile Acids and Salts