title: [Detailed monitoring of valproic acid and phenobarbital in the treatment of epilepsy in children].
abstract: 24-hour monitoring of the treatment of three children with refractory epilepsy with valproic acid and phenobarbital was carried out. This made possible a detailed analysis of the variability of valproate level in the serum over 24 hours and no relation was found between the level of the drug and its dose. A rise of phenobarbital level was observed when it was given with valproic acid, and this was associated with a reduction of seizure activity in the EEG. In view of a high variability of the valproate level over 24 hours detailed monitoring refractory cases seems useful and indispensable sometimes.
authors.affiliation: Kliniki Neurologicznej AM w Białymstoku.
authors.forename: W
authors.initials: W
authors.lastname: Sobaniec
authors.forename: E
authors.initials: E
authors.lastname: Jankowicz
authors.forename: K
authors.initials: K
authors.lastname: Czerwińska-Ciechan
mesh_terms: D000293:Adolescent; D002648:Child; D002940:Circadian Rhythm; D004359:Drug Therapy, Combination; D004831:Epilepsies, Myoclonic / Q000188:drug therapy*; D004832:Epilepsy, Absence / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D010634:Phenobarbital / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014635:Valproic Acid / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D014635:Valproic Acid; D010634:Phenobarbital
vernacular_title: Szczegółowe monitorowanie kwasu walproinowego i fenobarbitalu w leczeniu padaczki u dzieci.