title: Hercon technology for transdermal delivery of drugs.
abstract: The Hercon controlled drug delivery technology is based on a multi-layered laminated polymeric structure, in which a layer of vinyl chloride copolymer or terpolymer containing the drug is sandwiched between two or more layers of polymeric films. The drug is released from the device at a controlled rate by a process of diffusion through the reservoir and one of the outer layers, which can function as a rate controlling membrane. This basic technology has been successfully utilized for the development and commercialization of Nitroglycerin Transdermal System (NTS, Bolar Pharmaceutical Co., Inc). In vitro and in vivo investigations of transdermal delivery of different other drugs from the Hercon polymeric devices have indicated the feasibility of using this system to meet a variety of therapeutic needs.
authors.affiliation: Hercon Laboratories Corporation, South Plainfield, NJ 07080.
authors.forename: K R
authors.initials: KR
authors.lastname: Shah
authors.forename: S
authors.initials: S
authors.lastname: Ng
authors.forename: L
authors.initials: L
authors.lastname: Zeoli
authors.forename: V
authors.initials: V
authors.lastname: Haight
authors.forename: S
authors.initials: S
authors.lastname: Matz
authors.forename: A F
authors.initials: AF
authors.lastname: Kydonieus
mesh_terms: D000279:Administration, Cutaneous / Q000295:instrumentation; D000818:Animals; D001682:Biological Availability; D003000:Clonidine / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D004867:Equipment Design; D004958:Estradiol / Q000008:administration & dosage; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage; D005996:Nitroglycerin / Q000008:administration & dosage / Q000493:pharmacokinetics; D011453:Prostaglandins / Q000008:administration & dosage; D012601:Scopolamine / Q000008:administration & dosage; D013678:Technology, Pharmaceutical
chemical_list: D003692:Delayed-Action Preparations; D011453:Prostaglandins; D004958:Estradiol; D012601:Scopolamine; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate; D003000:Clonidine