MAO activity, serotonin metabolism and aggregation of platelets from migraine patients. A preliminary study.
Platelets of migraine patients showed abnormal behavior such as hyperaggregability and reduced monoamine oxidase activity (MAO). We measured the MAO activity, serotonin (5-HT) content and release, adenosine diphosphate (ADP)-induced aggregation, and the prostacyclin (PGI2) antiaggregatory effect using the same sample of platelets from migraine patients to find out if these characteristics are intercorrelated. A significant correlation between MAO activity and sensitivity to PGI2 was found.
Kovács
K
K
Dept. of Neurology, Semmelweis University of Medicine, Budapest, Hungary.
Tóthfalusi
L
L
Hermán
F
F
Magyar
K
K
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism*; D002746:Chlorpromazine / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000097:blood* / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism*; D010974:Platelet Aggregation; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D000244:Adenosine Diphosphate; D011464:Epoprostenol; D008995:Monoamine Oxidase; D002746:Chlorpromazine