Famotidine effects on theophylline pharmacokinetics in subjects affected by COPD. Comparison with cimetidine and placebo.
The effect of a new H2-antagonist, famotidine, on theophylline pharmacokinetics was compared with placebo and cimetidine in 26 patients affected by COPD. Cimetidine, placebo, and famotidine were administered, four days each drug at random, to all the subjects. Results suggest that famotidine, contrary to cimetidine, does not influence theophylline metabolism in man.
Verdiani
P
P
Divisione di Pneumologia, Ospedale G.A. Pizzetti, Grosseto, Italy.
Di Carlo
S
S
Baronti
A
A
D000368:Aged; D002927:Cimetidine / Q000494:pharmacology* / Q000627:therapeutic use; D015738:Famotidine; D005260:Female; D006207:Half-Life; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged; D013806:Theophylline / Q000493:pharmacokinetics* / Q000627:therapeutic use; D013844:Thiazoles / Q000494:pharmacology* / Q000627:therapeutic use
D013844:Thiazoles; D015738:Famotidine; D002927:Cimetidine; D013806:Theophylline