title: Oral manifestations of agranulocytosis associated with methimazole therapy.
abstract: This paper reports a case of agranulocytosis that developed in a patient with hyperthyroidism two months after the administration of methimazole. The patient manifested symptoms of fever, sore throat, profound leukopenia, and oral complications such as generalized gingival necrosis and mucosa ulceration, which subsequently abated upon withdrawal of the drug. Dental practitioners should be aware of the potential of agranulocytosis associated with methimazole therapy. The oral manifestations should be kept in mind.
authors.affiliation: Periodontal Department, School of Dentistry, Kaohsiung Medical College, Taiwan, Republic of China.
authors.forename: G L
authors.initials: GL
authors.lastname: Hou
authors.forename: C C
authors.initials: CC
authors.lastname: Tsai
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced*; D005260:Female; D005892:Gingivitis, Necrotizing Ulcerative / Q000139:chemically induced*; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D008713:Methimazole / Q000009:adverse effects*
chemical_list: D008713:Methimazole