AIDS: no association with the genetic systems GC (D-binding protein), ORM (orosomucoid = alpha-1-acid glycoprotein), and A2HS (alpha-2-HS-glycoprotein).
In a sample of 97 HIV-1 seropositive persons which comprised 34 patients with AIDS, 30 patients with persistent generalized lymphadenopathy or with AIDS related complex and 33 persons who were without symptoms and called "healthy", three genetic marker systems were examined: 1) GC, the group-specific component of serum which is identical with the vitamin D binding protein (DBP) of serum, 2) ORM, the acute phase protein orosomucoid = alpha-1-acid glycoprotein of serum, and 3) A2HS, the alpha-2-AS glycoprotein of serum. The distribution of the genotypes and of the alleles in the sample of AIDS patients and of HIV-1/positive persons was not different from the distribution in control groups. An association between susceptibility and/or resistance for AIDS and these genetic marker systems was not observed.
Cleve
H
H
Institut für Anthropologie und Humangenetik, Universität München.
Weidinger
S
S
Gürtler
L G
LG
Deinhardt
F
F
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics*; D000483:Alleles; D001798:Blood Proteins / Q000032:analysis* / Q000235:genetics; D004198:Disease Susceptibility; D004797:Enzyme-Linked Immunosorbent Assay; D005819:Genetic Markers; D005838:Genotype; D006679:HIV Seropositivity; D006801:Humans; D009961:Orosomucoid / Q000032:analysis* / Q000235:genetics; D010641:Phenotype; D060749:alpha-2-HS-Glycoprotein
C556354:AHSG protein, human; D001798:Blood Proteins; D005819:Genetic Markers; D009961:Orosomucoid; D060749:alpha-2-HS-Glycoprotein