[Effect of cytosine arabinoside on the cell cycle and level of radiation-induced chromosome anomalies in lymphocytes of mammals].
A treatment by cytosine arabinoside (ara-C), an inhibitor of repair, and by deoxycytidine, which reverse the inhibition activity of ara-C, has been used to study the duration of repair in X-irradiated mammalian lymphocytes. In human the repair requires at least three hours but is already completed within two hours for rabbit lymphocytes. The results appear rather surprising for pig lymphocytes because addition of ara-C to culture medium does not modify apparently the yield of aberrations.
Deknudt
G
G
Kalina
I
I
Léonard
A
A
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects; D002869:Chromosome Aberrations; D003561:Cytarabine / Q000494:pharmacology*; D003841:Deoxycytidine / Q000494:pharmacology; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects* / Q000648:ultrastructure; D011817:Rabbits; D013552:Swine; D013997:Time Factors
D003561:Cytarabine; D003841:Deoxycytidine
Effet du cytosine arabinoside sur le cycle cellulaire et le taux d'anomalies chromosomiques radioinduites dans les lymphocytes des Mammifères.