title: [Comparative evaluation of the physical methods for studying the pulmonary surfactant system during exposure to acute hypoxia].
abstract: Physical methods were used in rat experiments to study the effect of acute pressure chamber hypoxia on the pulmonary surfactant in pulmonary extracts of different concentrations, bronchoalveolar washing and extract after washing. The surfactant activity in health and disease depended on the substrate and its concentration. The corrective coefficients for comparison of the surface activity of different substrates were calculated. Acute hypoxia induced a decrease in pulmonary surfactant activity. During deadaptation, the cellular surfactant first returns to normal followed by normalization of the extracellular surfactant.
authors.forename: G V
authors.initials: GV
authors.lastname: Belov
authors.forename: A A
authors.initials: AA
authors.lastname: Arbuzov
authors.forename: V T
authors.initials: VT
authors.lastname: Davydov
mesh_terms: D000208:Acute Disease; D000222:Adaptation, Physiological; D000531:Altitude; D000818:Animals; D001273:Atmosphere Exposure Chambers; D000860:Hypoxia / Q000503:physiopathology*; D007707:Kyrgyzstan; D008722:Methods; D011663:Pulmonary Surfactants / Q000032:analysis*; D051381:Rats; D013997:Time Factors
chemical_list: D011663:Pulmonary Surfactants
vernacular_title: Sravnitel'naia otsenka fizicheskikh metodov issledovaniia surfaktantnoĭ sistemy legkikh pri deĭstvii ostroĭ gipoksii.