title: Kidney function in adults born with unilateral renal agenesis or nephrectomized in childhood.
abstract: We have evaluated the long-term prognosis in an unselected group of adult patients either uni-nephrectomized in childhood because of hydronephrosis or born with unilateral renal agenesis. Thirty-six patients aged 7-47 years were followed for 7-40 years. In 23 control subjects aged 20-47 years the glomerular filtration rate (GFR) and the p-aminohippuric acid clearance (CPAH) did not change significantly with age. In patients with a single kidney the size of that kidney was larger and GFR and CPAH were higher than single kidney values in control subjects. However, in patients with a single kidney since childhood the GFR and the CPAH declined slowly but significantly during the follow-up period. Significant microalbuminuria occurred in 47% of the patients with a single kidney and was more frequent with a longer follow-up period. No patient had renal insufficiency or a marked increase in arterial blood pressure. We conclude that in patients with a single kidney since childhood the long-term prognosis is good, but the late decrease in GFR and increase in albumin excretion may indicate a moderate risk for premature renal damage.
authors.affiliation: Department of Radiology, St. Göran's Children's Hospital, Karolinska Institute, Stockholm, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Wikstad
authors.forename: G
authors.initials: G
authors.lastname: Celsi
authors.forename: L
authors.initials: L
authors.lastname: Larsson
authors.forename: P
authors.initials: P
authors.lastname: Herin
authors.forename: A
authors.initials: A
authors.lastname: Aperia
mesh_terms: D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006869:Hydronephrosis / Q000503:physiopathology / Q000601:surgery; D007668:Kidney / Q000002:abnormalities* / Q000502:physiology; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects; D011379:Prognosis; D013997:Time Factors; D010130:p-Aminohippuric Acid / Q000493:pharmacokinetics
chemical_list: D010130:p-Aminohippuric Acid