Inhibition and excitation of neck and shoulder muscles during unilateral electrical stimulation of the rat neostriatum.
Electrical stimulation of the caudate-putamen (Cd-Pt) in anesthetized adult male rats was used to determine the nature and extent of the control exerted by the Cd-Pt over the following neck and shoulder muscles: the trapezius, biventer cervicis, rectus capitis and scalenus dorsalis. Unilateral Cd-Pt stimulation resulted in a pattern of muscle responses marked by immediate inhibition of ipsilateral spontaneous activity and subsequent excitation of contralateral activity. Lesions of the substantia nigra pars reticulata blocked the excitation in 3 of the 4 muscles, while globus pallidus lesions had equivocal results. However, control ablations of the frontoparietal motor cortex, which blocked excitation in all muscles, and kainic acid lesions of the Cd-Pt, which had no effect on excitation, suggested that the excitation of muscle activity can only be attributed to the stimulation of corticofugal fibers passing through this region (i.e. the Cd-Pt). The inhibition of spontaneous activity does appear to be attributable to stimulation of the Cd-Pt.
Kelland
M D
MD
Department of Psychology, Wayne State University, Detroit, MI 48202.
Asdourian
D
D
Kelland
D Z
DZ
D000818:Animals; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology*; D004558:Electric Stimulation; D004576:Electromyography; D005625:Frontal Lobe / Q000502:physiology; D008297:Male; D009044:Motor Cortex / Q000502:physiology; D009132:Muscles / Q000294:innervation*; D009334:Neck Muscles / Q000294:innervation*; D009412:Nerve Fibers / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D010296:Parietal Lobe / Q000502:physiology; D011699:Putamen / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012782:Shoulder / Q000294:innervation*