[Effects of long-term high doses of sex steroid hormones on human endometrial adenocarcinoma transplanted into nude mice].
To clarify the minute reactions of endometrial adenocarcinoma to sex steroid hormones, especially gestagen, an in vivo model (AD-30) transplanted into nude mice was established. The AD-30, well differentiated papillo-tubular type, was given 500 micrograms/kg/day of estradiol benzoate (E2) for 50 days or 0.1-100mg/kg/day of medroxyprogesterone acetate (MPA) for 120 days. Thereafter sequential histopathological changes, tumor growth curve and volume doubling time (VDT) were investigated as compared to the castrated control group. Histopathological changes: Following E2 administration, the cells increased in number and were packed in the tubular glands, and following a large dose of MPA, while secretory producing fluid was accumulated in the lumen, cells were shrunk, damaged and finally necrosed, but almost un affected cells were also observed. Tumor growth curve and VDT: E2 somewhat lifted the curve and shortened the VDT to 184 hr (control: 250 hr), while MPA produced various curves, some were diminished, some suppressed and others equal to the control group-with additional secretory fluid. Also MPA elongated the VDT to 412 hr.
Matsui
Y
Y
Sawada
M
M
Okudaira
Y
Y
D000231:Adenocarcinoma, Papillary / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008525:Medroxyprogesterone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D017258:Medroxyprogesterone Acetate; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology
D004958:Estradiol; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone