Polymorphism of Fc receptor on murine B cells is Igh-linked.
Analysis of mouse IgG binding to Fc receptors on mouse B cells indicates that the IgG1, IgG2a, and IgGb subclasses bind to the same receptor. No differences in affinity were detected among subclass or between mouse strains. This same receptor bound rat IgG with an affinity that differed between mouse strains. This polymorphism in affinity for rat IgG maps to chromosome 12 distal to the Igh locus.
Baum
C M
CM
McKearn
J P
JP
Riblet
R
R
Davie
J M
JM
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002874:Chromosome Mapping; D005796:Genes; D008040:Genetic Linkage; D007074:Immunoglobulin G / Q000378:metabolism; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D011110:Polymorphism, Genetic; D011961:Receptors, Fc / Q000235:genetics* / Q000378:metabolism; D017452:Receptors, IgG; D011995:Recombination, Genetic
D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D011961:Receptors, Fc; D017452:Receptors, IgG