title: Small-diameter vascular prostheses: two designs of PTFE and endothelial cell-seeded and nonseeded Dacron.
abstract: Despite numerous advances in biomaterials design and utilization, the perfect artificial small-vessel substitute has yet to be developed. Dacron and expanded polytetrafluoroethylene (PTFE) are two materials potentially appropriate for use as small-vessel prostheses. We report the patencies of endothelial cell-seeded and nonseeded 4 mm I.D. Dacron grafts and two designs of nonseeded 4 mm I.D. PTFE (Gore-Tex and Impra) in the carotid position in dogs. All graft lengths exceeded the calculated maximum critical length for the material being tested. Dacron grafts, both endothelial cell-seeded and nonseeded, achieved higher patencies than both designs of PTFE. Endothelial cell-seeded Dacron grafts achieved the highest patencies. Endothelium was present to a significant extent only on endothelial cell-seeded Dacron grafts. There was little pannus ingrowth or midgraft pseudointima on nonseeded Dacron or on patent PTFE grafts although thrombus-free surface areas of patent PTFE grafts were high. These comparative data support the utility of endothelial cell seeding in achieving high patencies of small-diameter vascular grafts.
authors.forename: S P
authors.initials: SP
authors.lastname: Schmidt
authors.forename: T J
authors.initials: TJ
authors.lastname: Hunter
authors.forename: M
authors.initials: M
authors.lastname: Hirko
authors.forename: T A
authors.initials: TA
authors.lastname: Belden
authors.forename: M M
authors.initials: MM
authors.lastname: Evancho
authors.forename: W V
authors.initials: WV
authors.lastname: Sharp
authors.forename: D L
authors.initials: DL
authors.lastname: Donovan
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis; D002339:Carotid Arteries / Q000601:surgery*; D004285:Dogs; D004727:Endothelium; D005260:Female; D006083:Graft Occlusion, Vascular; D008297:Male; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D013927:Thrombosis
chemical_list: D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene