The application of antibiotic bonding to the treatment of established vascular prosthetic infection.
We used surfactant-mediated antibiotic bonding to treat established vascular prosthetic infections in an animal model. The infrarenal aorta of dogs was replaced with a polytef (PTFE) graft locally contaminated with Staphylococcus aureus. Infected grafts were then replaced with control polytef or polytef bonded with benzylkonium chloride and penicillin G tagged with radioactive carbon, or polytef bonded with tridodecylmethylammonium chloride and penicillin G tagged with radioactive carbon. Both types of antibiotic-bonded grafts had significantly fewer infections than control grafts did. The labeled penicillin G remained bound to both groups of antibiotic-bonded grafts for at least three weeks. In a second group of studies, surfactant-treated polytef adsorbed parenterally administered labeled penicillin G in highly significant concentrations compared with control grafts. These studies suggest the possibility that human vascular prosthetic infection may be treated with an antibiotic-bonded graft.
Greco
R S
RS
Trooskin
S Z
SZ
Donetz
A P
AP
Harvey
R A
RA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001011:Aorta / Q000601:surgery; D001807:Blood Vessel Prosthesis; D004285:Dogs; D005260:Female; D010400:Penicillin G / Q000008:administration & dosage / Q000627:therapeutic use; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D013203:Staphylococcal Infections / Q000188:drug therapy; D013501:Surface-Active Agents; D013530:Surgical Wound Infection / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D011093:Polyethylene Terephthalates; D013501:Surface-Active Agents; D011138:Polytetrafluoroethylene; D010400:Penicillin G