title: Delayed magnetic resonance hepatic imaging with gadolinium-DTPA.
abstract: Magnetic resonance imaging of the liver was performed on 11 rabbits (3-5 kg) before and at 4, 5 and 6 hours after the intravenous administration of 0.3 mM/kg Gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) to determine if hepatocytes exhibit delayed excretion of Gd-DTPA, similar to the delayed hepatic excretion of iodinated contrast agents. Imaging was performed at 0.5 Tesla in the axial plane using a spin echo sequence of TR/TE, 250/20 milliseconds. Precontrast and postcontrast intensity changes for liver and muscle were standardized and compared over time. The average percent of postcontrast enhancement for liver and muscle, respectively was: 30.6 +/- 9.5% and 17.3 +/- 17.0% immediately postcontrast; 9.7 +/- 13.6% and 1.6 +/- 13.8% at 4 hours; 9.6 +/- 7.8% and 4.3 +/- 13.2% at 5 hours; and 11.0 +/- 7.8% and 4.1 +/- 11.7% at 6 hours. We conclude that there is not significant hepatocyte excretion of Gd-DTPA at 4 to 6 hours postcontrast injection in rabbits and that this may not be an advantageous paramagnetic contrast strategy for focal hepatic lesion detection.
authors.affiliation: Emory University School of Medicine, Department of Radiology, Atlanta, Georgia 30322.
authors.forename: R C
authors.initials: RC
authors.lastname: Nelson
authors.forename: M E
authors.initials: ME
authors.lastname: Umpierrez
authors.forename: J L
authors.initials: JL
authors.lastname: Chezmar
authors.forename: M E
authors.initials: ME
authors.lastname: Bernardino
mesh_terms: D000818:Animals; D003287:Contrast Media; D005260:Female; D005682:Gadolinium / Q000378:metabolism; D019786:Gadolinium DTPA; D007089:Image Enhancement; D008099:Liver / Q000033:anatomy & histology* / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009132:Muscles / Q000033:anatomy & histology; D009942:Organometallic Compounds / Q000378:metabolism; D004369:Pentetic Acid / Q000378:metabolism; D011817:Rabbits; D013997:Time Factors
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA