title: Isolation and structure of a pseudopeptide gamma-L-glutamyl-L-aspartic acid from Datura stramonium that impairs learning retention in mice.
abstract: Datura stramonium contains a compound that impairs learning retention in mice. It has been purified to homogeneity and its structure has been established as that of a gamma-L-glutamyl-L-aspartate. The biological activity of this pseudodipeptide has been found to be identical with that of the corresponding synthetic one. It has also been compared to those of various synthetic di- and tripeptides containing L- and/or D-enantiomers of the constitutive amino acids. The results show that the activity is associated with a peptidic structure containing only one type of enantiomer.
authors.affiliation: Laboratoire de Psychophysiologie, Strasbourg, France.
authors.forename: M
authors.initials: M
authors.lastname: Schmitz-Bourgeois
authors.forename: I
authors.initials: I
authors.lastname: Amiri
authors.forename: J
authors.initials: J
authors.lastname: Reinbolt
authors.forename: Y
authors.initials: Y
authors.lastname: Boulanger
authors.forename: A
authors.initials: A
authors.lastname: Ungerer
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D013286:Datura stramonium / Q000032:analysis*; D004151:Dipeptides / Q000302:isolation & purification* / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D051379:Mice; D010946:Plants, Medicinal; D010947:Plants, Toxic
chemical_list: D004151:Dipeptides; C021030:gamma-glutamylaspartic acid