Prevention of autoantibody formation and prolonged survival in New Zealand black/New Zealand white F1 mice fed dehydroisoandrosterone.
Dehydroisoandrosterone, administered orally to New Zealand Black/New Zealand White F1 hybrid mice, prevented the formation of antibodies to double-stranded DNA and prolonged survival in this murine model of lupus erythematosus.
Lucas
J A
JA
Ahmed
S A
SA
Casey
M L
ML
MacDonald
P C
PC
D000818:Animals; D000974:Antibodies, Antinuclear / Q000096:biosynthesis; D000917:Antibody Formation / Q000187:drug effects; D001323:Autoantibodies / Q000096:biosynthesis*; D004247:DNA / Q000276:immunology; D003687:Dehydroepiandrosterone / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D003687:Dehydroepiandrosterone; D004247:DNA