Improved gas chromatographic-mass spectrometric assay for haloperidol utilizing ammonia chemical ionization and selected-ion monitoring.
An improved method for the analysis of haloperidol in human serum, utilizing gas chromatography-ammonia chemical ionization mass spectrometry is described. A tetradeutero analogue of haloperidol is utilized as the internal standard, while a second drug, thioridazine, is added as a priming compound. The characteristic high sensitivity and selectivity of selected-ion monitoring combined with the added accuracy provided by incorporation of a labeled internal standard provide a reliable method for the quantitation of low levels of haloperidol.
Szczepanik-van Leeuwen
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D000641:Ammonia; D055598:Chemical Phenomena; D002621:Chemistry; D008401:Gas Chromatography-Mass Spectrometry; D006220:Haloperidol / Q000097:blood*; D006801:Humans; D006816:Huntington Disease / Q000097:blood; D012015:Reference Standards; D013881:Thioridazine / Q000097:blood
D000641:Ammonia; D006220:Haloperidol; D013881:Thioridazine