[Comparative study of 3 positive controls for routine prick tests in children: 48/80, 1 mg histamine and 5 mg histamine].
We compared, among 153 children 2 to 14 years old, responses to some positive control solutions for prick tests made with a Stallerpoint. We obtained the following values: -6% - 48/80:4.46 +/- 1.88 mm -1 mg/ml Histamine:3.49 +/- 1.67 mm -5 mg/ml Histamine:5.13 +/- 1.78 mm. 1 mg/ml histamine gives too many null responses (12/153) to represent a valuable positive control. 5 mg/ml histamine, on the other hand, gives some very strong reactions which may induce an underestimation of responses to allergen tests. Compound 48/80 seems to remain the best positive control for prick test exploration of immediate allergy in children. An alternative might be an intermediate solution of histamine 2.5 mg/ml.
Lelong
M
M
Service de Pédiatrie, Centre Hospitalier, Lens.
Thibaudon
M
M
Polaert
J
J
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006632:Histamine / Q000592:standards; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis; D007202:Indicators and Reagents / Q000592:standards; D012015:Reference Standards; D012882:Skin Tests / Q000379:methods / Q000592:standards; D012996:Solutions / Q000592:standards; D003189:p-Methoxy-N-methylphenethylamine / Q000592:standards
D007202:Indicators and Reagents; D012996:Solutions; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine
Etude comparative chez l'enfant de trois témoins positifs pour la pratique des prick tests: 48/80, histamine 1 mg et histamine 5 mg.