Mitomycin C-induced meiotic crossing-over on the interstitial segments in the Chinese hamster heterozygous for a reciprocal translocation.
Using Chinese hamsters heterozygous for T(2;10)3Idr and T(1;3)8Idr reciprocal translocations, the authors studied mitomycin C (MMC)-induced crossing-over on the interstitial segments. Marker chromosomes with unequal-length chromatids resulting from crossing-over were clearly detectable, and the frequencies of such marker chromosomes were constant among individual males which were heterozygous for the same reciprocal translocation. The frequency of MMC-induced crossing-over on the interstitial segments increased roughly with increase in dose. These findings, therefore, indicated that marker chromosomes with unequal-length chromatids in translocation heterozygotes may be a useful indicator for detection of the cytogenetic effects of environmental mutagens on germ cells.
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Department of Genetics, Aichi Prefectural Colony for the Mentally and Physically Handicapped, Kasugai.
Kong
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D000818:Animals; D006224:Cricetinae; D003412:Cricetulus / Q000235:genetics; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005819:Genetic Markers; D006579:Heterozygote; D008297:Male; D008540:Meiosis / Q000187:drug effects*; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage / Q000633:toxicity*; D009153:Mutagens; D014178:Translocation, Genetic
D005819:Genetic Markers; D008937:Mitomycins; D009153:Mutagens; D016685:Mitomycin