Coronary hemodynamics during left and right coronary arteriography with an ionic and nonionic contrast medium.
The direct effects of ionic amidotrizoate (iodine content 370 mg/ml, osmolality 2.1 osmol/kg) and nonionic iopamidol (iodine content 370/ml, osmolality 0.8 osmol/kg) on the coronary circulation were intraindividually compared in 10 patients suffering from coronary heart disease. In accordance with a double-blind, crossover protocol, both contrast media were injected into the left and right coronary arteries (8 ml and 5 ml per injection, respectively). Injections of both dyes into the left coronary artery caused a similar decrease in heart rate. The prolongation in the QT interval was significantly greater after amidotrizoate (p less than 0.05). Systolic (p less than 0.01) and diastolic (p less than 0.05) aortic pressures decreased to a greater extent following amidotrizoate injection. Each contrast agent produced a similar increase in coronary sinus flow, but iopamidol resulted in a smaller decrease in coronary vascular resistance (p less than 0.05). After right coronary artery injections, both contrast media caused bradycardia and prolongation of the QT interval, a decrease in systolic and diastolic aortic pressure, a rise in coronary sinus flow, and a lowering of coronary vascular resistance. Though most changes were more pronounced following amidotrizoate injection, the differences in the ionic and the nonionic agent were not statistically significant. Thus, after selective coronary arteriography, both contrast media caused a transient drop in coronary vascular resistance and a rise in coronary sinus flow despite a decrease in aortic pressure. The effects of amidotrizoate were more marked, which might be attributed to the higher osmolality of this ionic contrast medium. Coronary hemodynamics, however, usually returned to baseline values within 1 minute.(ABSTRACT TRUNCATED AT 250 WORDS)
Schräder
R
R
Department of Internal Medicine, Medical School, Johann Wolfgang Goethe-University, Frankfurt am Main, Federal Republic of Germany.
Sievert
H
H
Frey
G
G
Schmidt
T
T
Kaltenbach
M
M
Kober
G
G
D000792:Angiography; D001794:Blood Pressure / Q000187:drug effects; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000000981:diagnostic imaging; D003331:Coronary Vessels / Q000503:physiopathology; D003973:Diatrizoate; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007479:Iopamidol; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D014655:Vascular Resistance / Q000187:drug effects
D003973:Diatrizoate; D007479:Iopamidol