title: Prediction of steady-state oxygen consumption during norepinephrine infusions in humans.
abstract: A method for predicting maximal oxygen consumption during norepinephrine infusion is described. Using the initial response and enzyme kinetics, predicted values of maximal oxygen consumption were compared with observed values and a coefficient of variation of 1.4% was obtained. This method is of use in situations where it may not be possible to achieve steady-state conditions, especially with high doses of norepinephrine, and it permits comparison of maximal oxygen consumption between groups.
authors.affiliation: Department of Physiology, St John's Medical College, Bangalore, India.
authors.forename: M L
authors.initials: ML
authors.lastname: Sheela
authors.forename: A V
authors.initials: AV
authors.lastname: Kurpad
authors.forename: R N
authors.initials: RN
authors.lastname: Kulkarni
authors.forename: P S
authors.initials: PS
authors.lastname: Shetty
mesh_terms: D000328:Adult; D001833:Body Temperature Regulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008954:Models, Biological; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*
chemical_list: D009638:Norepinephrine