Mouse ovarian tumor cells: an experimental model for progestin-mediated radiotherapy.
Mouse ovarian tumor (MOT) cells have been grown in C3HeB/FeJ mice as an ascites and as a subcutaneous tumor and in cell culture as a suspension. These cells contain saturable, high-affinity, specific progesterone receptors. Estrogen receptors were not detectable in these cells. MOT cells can be used as both an in vivo and an in vitro model for progestin-mediated radiotherapy.
Blumenthal
R D
RD
Department of Radiotherapy, Mount Sinai School of Medicine, New York.
McLaughlin
W H
WH
Jordan
J J
JJ
Cryan
E V
EV
Bloomer
W D
WD
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D010051:Ovarian Neoplasms / Q000032:analysis / Q000473:pathology / Q000532:radiotherapy*; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis*; D014407:Tumor Cells, Cultured
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone