Subacute and chronic bone infections: diagnosis using In-111, Ga-67 and Tc-99m MDP bone scintigraphy, and radiography.
The usefulness of indium-111 white blood cell scintigraphy in the diagnosis of subacute or chronic bone infection was examined in 21 orthopedic patients. In-111 WBC imaging was compared with gallium-67 and technetium-99m methylene diphosphonate skeletal scintigraphy and bone radiography, all studies being performed within 1 week. In-111 WBC scintigraphy showed no definite advantage over Ga-67 scintigraphy in the identification of chronic bone infection. The two tests had the same sensitivity (80%) and similar specificity (In-111 WBC 75%, Ga-67 83%; difference not significant). Bone radiography had a sensitivity of 60% and a specificity of 67%. A negative Tc-99m MDP bone scintigram ruled out infection (sensitivity 100%), but because of low specificity (25%), final evaluation required performance of Ga-67 or In-111 WBC scintigraphy.
Al-Sheikh
W
W
Sfakianakis
G N
GN
Mnaymneh
W
W
Hourani
M
M
Heal
A
A
Duncan
R C
RC
Burnett
A
A
Ashkar
F S
FS
Serafini
A N
AN
D000328:Adult; D000368:Aged; D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D002908:Chronic Disease; D004164:Diphosphonates; D005710:Gallium Radioisotopes; D006801:Humans; D007204:Indium; D007239:Infections / Q000000981:diagnostic imaging*; D007962:Leukocytes; D008875:Middle Aged; D011859:Radiography; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013667:Technetium; D013669:Technetium Tc 99m Medronate
D004164:Diphosphonates; D005710:Gallium Radioisotopes; D011868:Radioisotopes; D007204:Indium; D013667:Technetium; D013669:Technetium Tc 99m Medronate