Inhibition of HIV replication by amino-sugar derivatives.
The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and deoxynojirimycin have recently been shown to have potential anti-HIV activity [(1987) Proc. Natl. Acad. Sci. USA 84, 8120-8124; (1987) Nature 330, 74-77; (1987) Lancet i, 1025-1026]. They are thought to act by inhibiting alpha-glucosidase I, an enzyme involved in the processing of N-linked oligosaccharides on glycoproteins. We report here the relative efficacy of a spectrum of amino-sugar derivatives as inhibition of HIV cytopathicity. Several alpha-glucosidase inhibitors and alpha-fucosidase inhibitors were found to be active at concentrations which were non-cytotoxic.
Fleet
G W
GW
Dyson Perrins Laboratory, Department of Organic Chemistry, University of Oxford, England.
Karpas
A
A
Dwek
R A
RA
Fellows
L E
LE
Tyms
A S
AS
Petursson
S
S
Namgoong
S K
SK
Ramsden
N G
NG
Smith
P W
PW
Son
J C
JC
D000606:Amino Sugars / Q000494:pharmacology*; D002460:Cell Line; D004261:DNA Replication / Q000187:drug effects; D006678:HIV / Q000187:drug effects*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics; D015498:HIV-2 / Q000187:drug effects / Q000235:genetics; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
D000606:Amino Sugars