Suppression of generation of concomitant antitumor immunity by passively transferred suppressor T cells from tumor-bearing donors.
Infusion of normal recipient mice with suppressor T cells from donors bearing a progressive Meth A fibrosarcoma results in a diminished capacity of the recipients to generate concomitant and postexcision antitumor immunity. The passive transfer of suppressor cells which prevented the generation of immunity to the Meth A fibrosarcoma did not affect the capacity of the recipients to reject an allogeneic tumor. The data provides direct evidence in support of the hypothesis that suppressor T cells, generated at later stages of growth of Meth A fibrosarcoma, function to down-regulate an already acquired mechanism of concomitant immunity.
Bursuker
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North
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D000818:Animals; D005354:Fibrosarcoma / Q000139:chemically induced / Q000276:immunology*; D007116:Immunization, Passive; D008748:Methylcholanthrene; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D008748:Methylcholanthrene