title: Brain neocortex immunomodulation in rats.
abstract: The influence of the cerebral neocortex on the immune system was studied in groups of male Wistar rats after lesioning the right or the left fronto-parietal cortex. In left-lesioned rats, mitogenesis of T-lymphocytes induced either by phytohemagglutinin or Urtica Dioca Agglutinin was depressed by about 25-40% as compared to controls. In contrast, T-cell mitogenesis in animals with right lesions, was enhanced by about 20-45% as compared to controls and by about 90% as compared to that observed in left-lesioned animals. Cortical lesions of either side were shown not to modify antibody synthesis and plasma levels of ACTH, or prolactin. These results, quite similar to those that we have previously observed in female mice, suggest that lateralization in brain cortex immunomodulatory functions may exist in both sexes and in several species of mammals.
authors.affiliation: I.N.S.E.R.M. U. 259, Université de Bordeaux II, France.
authors.forename: P
authors.initials: P
authors.lastname: Barnéoud
authors.forename: P J
authors.initials: PJ
authors.lastname: Neveu
authors.forename: S
authors.initials: S
authors.lastname: Vitiello
authors.forename: P
authors.initials: P
authors.lastname: Mormède
authors.forename: M
authors.initials: M
authors.lastname: Le Moal
mesh_terms: D000818:Animals; D001921:Brain / Q000276:immunology*; D007143:Immunoglobulin Heavy Chains / Q000378:metabolism*; D007142:Immunoglobulin gamma-Chains / Q000378:metabolism*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000166:cytology / Q000502:physiology*; D008297:Male; D015213:Neuroimmunomodulation; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains