Fixed drug eruption.
We presented 21 patients with fixed drug eruptions. All of them had positive provocation tests, showing the usefulness of this test for diagnosis. The lesions appeared on the skin or mucous membranes within 20 min. to 10 hours, after an oral provocation test with a sub-therapeutic dose. In those cases where we performed the basophil degranulation test, they were all negative. The drug more frequently implicated was cotrimoxazole (71%). In one patient the eruption was produced by oral neomycin.
Gómez
B
B
Sastre
J
J
Azofra
J
J
Sastre
A
A
D000284:Administration, Oral; D001241:Aspirin / Q000009:adverse effects*; D001491:Basophils / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D003594:Cytoplasmic Granules; D004338:Drug Combinations / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D009355:Neomycin / Q000009:adverse effects*; D010118:Oxytetracycline / Q000009:adverse effects*; D010328:Patch Tests; D011720:Pyrazoles / Q000009:adverse effects*; D047069:Pyrazolones; D013420:Sulfamethoxazole / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D004338:Drug Combinations; D011720:Pyrazoles; D047069:Pyrazolones; C038362:pyrazolone; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D009355:Neomycin; D013420:Sulfamethoxazole; D001241:Aspirin; D010118:Oxytetracycline