title: Suppression of HIV p24 antigen and induction of HIV anti-p24 antibody by alpha interferon in patients with chronic hepatitis B.
abstract: Five HIV p24 antigen (p24Ag)-positive patients received alpha interferon during trials of therapy for hepatitis B. Four of these showed marked falls in p24Ag during treatment. One of the two patients who became p24Ag-negative [corrected] developed anti-p24 antibodies (anti-p24). Five out of nine p24Ag-negative HIV-antibody-positive patients showed a rise in anti-p24 titres during interferon therapy, whereas only two out of six untreated controls showed a similar rise. This study provides evidence that alpha interferon has anti-HIV activity in vivo.
authors.affiliation: Department of Infectious Diseases, Royal Free Hospital, London, UK.
authors.forename: M G
authors.initials: MG
authors.lastname: Brook
authors.forename: D
authors.initials: D
authors.lastname: Gor
authors.forename: S M
authors.initials: SM
authors.lastname: Forster
authors.forename: W
authors.initials: W
authors.lastname: Harris
authors.forename: D J
authors.initials: DJ
authors.lastname: Jeffries
authors.forename: H C
authors.initials: HC
authors.lastname: Thomas
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D015483:HIV Antibodies / Q000096:biosynthesis*; D015488:HIV Antigens / Q000032:analysis; D016655:HIV Core Protein p24; D006679:HIV Seropositivity / Q000150:complications / Q000628:therapy*; D006509:Hepatitis B / Q000150:complications / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008875:Middle Aged; D011897:Random Allocation; D012191:Retroviridae Proteins / Q000276:immunology
chemical_list: D015483:HIV Antibodies; D015488:HIV Antigens; D016655:HIV Core Protein p24; D007370:Interferon Type I; D012191:Retroviridae Proteins