UVB-induced melanocyte proliferation and 5-S-cysteinyldopa excretion in dysplastic nevus syndrome.
This is the first in vivo study of the effects of UV on the epidermal melanocytes in dysplastic nevus syndrome (DNS). Eleven DNS patients and 22 healthy subjects were given total body UVB irradiation 8 times during 17 days and the melanocyte population was estimated in biopsies from shielded and irradiated skin. There was a doubling of the melanocyte counts in irradiated skin and a less pronounced but significant increase in the shielded skin area. The urinary excretion of 5-S-cysteinyldopa (5-S-CD) was measured before, during and after the irradiation period. The 5-S-CD excretion reached a maximum after 2 weeks of irradiation and returned towards the basal value after the irradiation period. We were not able to document any abnormal melanocytic UV response in DNS patients before, during or after the irradiation.
Stierner
U
U
Department of Oncology, University of Gothenburg, Sweden.
Augustsson
A
A
Rosdahl
I
I
Kågedal
B
B
Suurküla
M
M
D000328:Adult; D000368:Aged; D002452:Cell Count; D002455:Cell Division / Q000528:radiation effects; D002851:Chromatography, High Pressure Liquid; D003548:Cysteinyldopa / Q000032:analysis / Q000652:urine*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D004416:Dysplastic Nevus Syndrome / Q000473:pathology / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000473:pathology / Q000528:radiation effects*; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D014466:Ultraviolet Rays
D003548:Cysteinyldopa; D004295:Dihydroxyphenylalanine