[Hormonal regulation of expression of the oncogene v-src in mouse fibroblasts NIH 3T3].
NIH 3T3 cells were transfected by plasmid containing v-src under control of hormone-regulated LTR MMTV (pMLsrc10). This plasmid caused the foci of morphologically transformed cells. The transformed cells induced rapidly growing tumours in nude mice. In the presence of dexamethasone the efficiency of NIH 3T3 cell transformation increased ten times, while tumourigenicity remained unchanged.
Kolobkov
S L
SL
Komissarova
E V
EV
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000473:pathology; D003907:Dexamethasone / Q000494:pharmacology; D005786:Gene Expression Regulation; D051379:Mice; D009368:Neoplasm Transplantation; D009857:Oncogenes; D010957:Plasmids; D011401:Promoter Regions, Genetic; D011965:Receptors, Glucocorticoid / Q000235:genetics* / Q000502:physiology; D014162:Transfection
D011965:Receptors, Glucocorticoid; D003907:Dexamethasone
Gormonal'naia reguliatsiia ékspressii onkogena v-src v myshinykh fibroblastakh NIH 3T3.