title: [Lethal and mutagenic action of incorporated 5-3H-cytosine on extracellular phage lambda].
abstract: A study was made of the lethal and mutagenic effects on extracellular phage gamma of 5-3H-cytosine incorporated into DNA. The efficiencies of inactivation by incorporated 3H were equal for 5-3H-cytosine and [3H-methyl]-thymidine, but the yield of c-mutations for the former was 14 times higher. The lethal and mutagenic effects of incorporated 5-3H-cytosine did not depend on ung mutation of host cells which caused a deficiency in uracil-DNA-glycosylase. The mutagenic effect was not enhanced when SOS-repair system was induced by UV-radiation. The mutagenic effect of 5-3H-cytosine was associated with the modified mispairing bases but not with uracil residues.
authors.forename: L V
authors.initials: LV
authors.lastname: Konevega
authors.forename: V L
authors.initials: VL
authors.lastname: Kalinin
mesh_terms: D010582:Bacteriophage lambda / Q000378:metabolism / Q000528:radiation effects*; D003596:Cytosine / Q000378:metabolism / Q000494:pharmacology*; D045647:DNA Glycosylases; D004260:DNA Repair / Q000528:radiation effects; D004279:DNA, Viral / Q000378:metabolism / Q000528:radiation effects; D009154:Mutation; D009699:N-Glycosyl Hydrolases / Q000528:radiation effects; D014316:Tritium / Q000378:metabolism / Q000494:pharmacology*; D014466:Ultraviolet Rays; D051981:Uracil-DNA Glycosidase
chemical_list: D004279:DNA, Viral; D014316:Tritium; D003596:Cytosine; D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases; D051981:Uracil-DNA Glycosidase
vernacular_title: Letal'noe i mutagennoe deĭstvie inkorporirovannogo 5-3H-tsitozina na vnekletochnyĭ fag lamda.