Small-diameter vascular prostheses: two designs of PTFE and endothelial cell-seeded and nonseeded Dacron.
Despite numerous advances in biomaterials design and utilization, the perfect artificial small-vessel substitute has yet to be developed. Dacron and expanded polytetrafluoroethylene (PTFE) are two materials potentially appropriate for use as small-vessel prostheses. We report the patencies of endothelial cell-seeded and nonseeded 4 mm I.D. Dacron grafts and two designs of nonseeded 4 mm I.D. PTFE (Gore-Tex and Impra) in the carotid position in dogs. All graft lengths exceeded the calculated maximum critical length for the material being tested. Dacron grafts, both endothelial cell-seeded and nonseeded, achieved higher patencies than both designs of PTFE. Endothelial cell-seeded Dacron grafts achieved the highest patencies. Endothelium was present to a significant extent only on endothelial cell-seeded Dacron grafts. There was little pannus ingrowth or midgraft pseudointima on nonseeded Dacron or on patent PTFE grafts although thrombus-free surface areas of patent PTFE grafts were high. These comparative data support the utility of endothelial cell seeding in achieving high patencies of small-diameter vascular grafts.
Schmidt
S P
SP
Hunter
T J
TJ
Hirko
M
M
Belden
T A
TA
Evancho
M M
MM
Sharp
W V
WV
Donovan
D L
DL
D000818:Animals; D001807:Blood Vessel Prosthesis; D002339:Carotid Arteries / Q000601:surgery*; D004285:Dogs; D004727:Endothelium; D005260:Female; D006083:Graft Occlusion, Vascular; D008297:Male; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D013927:Thrombosis
D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene