title: Tissue damage markers in experimental Chagas' disease.
abstract: Malondialdehydemia (MDA), measurements of heart and liver tissue damage (TDU), plasma activity of heart alpha-hydroxybutyrate dehydrogenase (LDH1) and liver lactate dehydrogenase (LDH5) were determined in non-infected mice and in mice infected with 10(5) T. cruzi, Y strain, bloodstream trypomastigotes. All the parameters measured were increased (P less than 0.01) in infected mice 8 days after intraperitoneal inoculation. The results indicate that plasma MDA levels can serve as a useful indicator of the systemic tissue injury found in Chagas' disease.
authors.affiliation: Departamento de Protozoologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil.
authors.forename: P E
authors.initials: PE
authors.lastname: Palhares
authors.forename: P
authors.initials: P
authors.lastname: Fontana Júnior
authors.forename: G M
authors.initials: GM
authors.lastname: Schaffer
authors.forename: N S
authors.initials: NS
authors.lastname: Marcondes
authors.forename: M
authors.initials: M
authors.lastname: Vergara
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D014355:Chagas Disease / Q000097:blood*; D006884:Hydroxybutyrate Dehydrogenase / Q000097:blood; D007527:Isoenzymes / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000201:enzymology*; D008297:Male; D008314:Malonates / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood*; D051379:Mice; D009206:Myocardium / Q000201:enzymology*
chemical_list: D007527:Isoenzymes; D008314:Malonates; D008315:Malondialdehyde; C035749:2-hydroxybutyrate dehydrogenase; D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase