Metabolism of medroxyprogesterone acetate and hepatic drug metabolism activity.
The effect of microsomal enzyme activity on the hepatic metabolism of medroxyprogesterone acetate (MPA), measured in vitro, and the MPA concentrations in liver and plasma were investigated in rats with intact and injured livers before and after MPA therapy. The amount of total MPA metabolites and the activity of drug-metabolizing enzyme system changed in a parallel manner in the livers. The ratio of liver/plasma concentration of MPA was decreased in the liver injury. The hepatic metabolism of MPA is accelerated during MPA treatment in rat.
Rautio
A
A
Saarni
H U
HU
Arranto
A J
AJ
Stengård
J H
JH
Kärki
N T
NT
Sotaniemi
E A
EA
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D004128:Dimethylnitrosamine / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000378:metabolism; D017258:Medroxyprogesterone Acetate; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats
D000970:Antineoplastic Agents; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone; D004128:Dimethylnitrosamine