title: Susceptibility of Pseudomonas pseudomallei to new beta-lactam and aminoglycoside antibiotics.
abstract: Pseudomonas pseudomallei is resistant to many antimicrobial agents. We determined the susceptibility to twelve beta-lactams and six aminoglycosides of twelve isolates of P. pseudomallei. Imipenem (MIC range 0.5-1.0 mg/l; MIC90 1.0 mg/l), ceftazidime (MIC range 1-8 mg/l; MIC90 8.0 mg/l), amoxycillin/clavulanate (MIC range 4-8 mg/l; MIC90 8.0 mg/l), piperacillin (MIC range 4-16 mg/l; MIC90 8.0 mg/l), and carumonam (MIC range 4-16 mg/l; MIC90 8.0 mg/l) were the most active. Aminoglycosides were relatively inactive, for example, gentamicin (MIC range 16-64 mg/l; MIC90 64 mg/l), netilmicin (MIC range 16-128 mg/l; MIC90 128 mg/l) and amikacin (MIC range 32-64 mg/l; MIC90 64 mg/l).
authors.affiliation: Department of Clinical Tropical Medicine, London School of Hygiene and Tropical Medicine, UK.
authors.forename: D W
authors.initials: DW
authors.lastname: McEniry
authors.forename: S H
authors.initials: SH
authors.lastname: Gillespie
authors.forename: D
authors.initials: D
authors.lastname: Felmingham
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D015378:Imipenem; D008554:Melioidosis / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D011549:Pseudomonas / Q000187:drug effects*; D013845:Thienamycins / Q000494:pharmacology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D013845:Thienamycins; D015378:Imipenem