[Effect of the enzyme preparation longolytin on fibrinolysis in animals].
It has been established that fibrinolytically active enzyme longolytine isolated from the culture fluid of the saprophyte fungus Arthrobotrys longa at intravenous injection favours the prolonged increase of the plasma fibrinolytic properties as well as activation of endogenic plasminogen. Maximum values of fibrinolytic activity have been marked in 5 and 30 min after enzyme intravenous injection. The plasminogen activity is high in 120 min. The fibrinolysis indexes--fibrinolytic activity of the euglobulin fraction and amount of plasminogen activator--in 3,5 and 5 times higher than in vitro at intravenous injection. The activation of coagulation system does not occur.
Serebriakova
T N
TN
Andreenko
G V
GV
Tsymanovich
S G
SG
Maksimova
R A
RA
Sharkova
T S
TS
D000818:Animals; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D005341:Fibrinolysin / Q000032:analysis; D005342:Fibrinolysis / Q000187:drug effects*; D008297:Male; D010447:Peptide Hydrolases / Q000494:pharmacology*; D010958:Plasminogen / Q000032:analysis; D010960:Plasminogen Activators / Q000097:blood; D051381:Rats; D012712:Serum Globulins / Q000032:analysis; D013997:Time Factors; D000979:alpha-2-Antiplasmin / Q000032:analysis
D005338:Fibrin Fibrinogen Degradation Products; D012712:Serum Globulins; D000979:alpha-2-Antiplasmin; D005340:Fibrinogen; D010958:Plasminogen; D010447:Peptide Hydrolases; C037962:longolytin; D010960:Plasminogen Activators; D005341:Fibrinolysin
Vliianie fermentnogo preparata longolitina na fibrinoliz u zhivotnykh.