[Treatment of oligospermic patients with varicocele].
The management of oligospermic patients with varicocele was reviewed. Varicocelectomy was performed in 46 oligospermic patients with varicocele (group 1) and kallikrein treatment was followed for those who failed to improve the semen quality after varicocelectomy (group 2). Twenty oligospermic patients with varicocele were given kallikrein for over 6 months as an initial treatment (group 3). A significant increase in total motile sperm count was noted in 34.8% of the patients in group 1, 22.7% in group 2, and 30.0% in group 3 respectively. Conception rate which was calculated after excluding couples, in which the partner received either artificial insemination by husband or any gynecological treatment, was 20.8% in group 1, 15.4% in group 2, 25.0% in group 3 respectively. No significant changes in hormonal data was observed after either treatment, but semen quality was not improved in patients who showed high serum level of luteinizing hormone (LH) or follicle stimulating hormone (FSH). Kallikrein is useful for oligospermic patients with varicocele as an initial treatment and for those in whom semen quality was not improved after varicocelectomy. Varicocelectomy and/or kallikrein treatment can be recommended mainly for those who show normal serum level of LH and FSH.
Shinoda
M
M
Department of Urology, School of Medicine, Fujita Gakuen Health University.
Naide
Y
Y
Tazaki
H
H
D005306:Fertilization; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007610:Kallikreins / Q000627:therapeutic use; D008026:Ligation; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009845:Oligospermia / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D013076:Sperm Count; D013081:Sperm Motility; D014646:Varicocele / Q000097:blood / Q000150:complications* / Q000601:surgery
D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D007610:Kallikreins