Tumor necrosis factor and HIV P24 antigen levels in serum of HIV-infected populations.
Tumor necrosis factor (TNF) and HIV P24 antigen levels were determined in the serum of intravenous drug abusers (IVDAs), homosexuals, and patients with lymphadenopathy or acquired immune deficiency syndrome (AIDS). The mean TNF level in the serum of normal controls was 12 +/- 5 compared to 112 +/- 25 pg/ml in the serum of HIV-seronegative asymptomatic IVDAs. This increase of TNF may be due to the variety of infections that these people are exposed to persistently. The mean TNF level in the serum of HIV-seropositive asymptomatic IVDAs was 112 +/- 79 pg/ml, 31 +/- 24 pg/ml in lymphadenopathy, and 55 +/- 19 pg/ml in patients with AIDS. The mean P24 level in the serum of patients with AIDS was 50 +/- 13 pg/ml compared to 0 pg/ml in HIV-seronegative subjects, while the other HIV-seropositive groups had relatively low levels. The P24 antigen levels may reflect viral load in these patients. SIL-2R and beta2-microglobulin levels were also elevated in patients with HIV infection . The TNF may play a role in the antiviral activity against HIV virus and in the development of full-blown disease after HIV infection.
Reddy
M M
MM
R. A. Cooke Institute of Allergy, St. Luke's-Roosevelt Hospital Center, New York, NY 10019.
Sorrell
S J
SJ
Lange
M
M
Grieco
M H
MH
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000276:immunology; D015483:HIV Antibodies / Q000032:analysis; D016655:HIV Core Protein p24; D006679:HIV Seropositivity; D006716:Homosexuality; D006801:Humans; D008206:Lymphatic Diseases / Q000097:blood / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012191:Retroviridae Proteins / Q000097:blood*; D019966:Substance-Related Disorders / Q000097:blood / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D001613:beta 2-Microglobulin / Q000032:analysis
D015483:HIV Antibodies; D016655:HIV Core Protein p24; D015375:Receptors, Interleukin-2; D012191:Retroviridae Proteins; D014409:Tumor Necrosis Factor-alpha; D001613:beta 2-Microglobulin