Multidirectional interactions in an Mls-disparate response.
The murine T cell clone E11, isolated from a primary H-2k-histocompatible, one-way mixed lymphocyte culture of B10.BR anti-C3H/Tif spleen cells, has been used to analyse multidirectional interactions in Mls-disparate responses. Several events can be observed. There is proliferation of T cells upon stimulation by macrophages or B cells of Mls-disparate stimulator cells. In addition, one finds induction of differentiation of B cells of stimulator strains. E11 T cells inhibit spreading and differentiation of macrophages of stimulator strains and also prevent the production of a T cell growth-supporting mediator by Mls-disparate spleen cells. All these phenomena can be explained by Mlsa,d,e-specific induction of gamma-interferon (gamma-IFN) production in the responder B10.BR (Mlsb) E11 T cells. It is suggested that gamma-IFN, as a regulator of feedback mechanisms, plays an essential role in Mls-disparate cell interactions.
Goldbach
J
J
Institut für Immunologie, Universität Münster, FRG.
Kirchner
H
H
Kölsch
E
E
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D002450:Cell Communication; D002999:Clone Cells / Q000276:immunology; D007371:Interferon-gamma / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D016747:Minor Lymphocyte Stimulatory Antigens; D013601:T-Lymphocytes / Q000276:immunology / Q000528:radiation effects
D000954:Antigens, Surface; D016747:Minor Lymphocyte Stimulatory Antigens; D007371:Interferon-gamma