Pericentric inversion of chromosome 19 in three families.
Pericentric inversion of chromosome 19 has been found in several members of three unrelated families from a restricted geographical region. In one of the families, an additional pericentric inversion of chromosome 9 was observed. Reproductive problems, multiple abortions in two families and a neonatal death in the third, were present. A review of previously described cases is included, and the genetic risk connected with this type of rearrangement is also discussed.
D'Alessandro
E
E
Dipartimento di Medicina Interna e Sanità Pubblica, Università dell'Aquila, Italy.
De Matteis Vaccarella
C
C
Lo Re
M L
ML
Cappa
F
F
D'Alfonso
A
A
Discepoli
S
S
Della Penna
M R
MR
Del Porto
G
G
D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D002871:Chromosome Banding; D007446:Chromosome Inversion; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D011247:Pregnancy; D012307:Risk Factors