title: Late onset of Huntington's disease.
abstract: Twenty-five patients with late-onset Huntington's disease were studied; motor impairment appeared at age 50 years or later. The average age at onset of chorea was 57.5 years, with an average age at diagnosis of 63.1 years. Approximately 25% of persons affected by Huntington's disease exhibit late onset. A preponderance of maternal transmission was noted in late-onset Huntington's disease. The clinical features resembled those of mid-life onset Huntington's disease but progressed more slowly. Neuropathological evaluation of two cases reveal less severe neuronal atrophy than for mid-life onset disease.
authors.forename: R H
authors.initials: RH
authors.lastname: Myers
authors.forename: D S
authors.initials: DS
authors.lastname: Sax
authors.forename: M
authors.initials: M
authors.lastname: Schoenfeld
authors.forename: E D
authors.initials: ED
authors.lastname: Bird
authors.forename: P A
authors.initials: PA
authors.lastname: Wolf
authors.forename: J P
authors.initials: JP
authors.lastname: Vonsattel
authors.forename: R F
authors.initials: RF
authors.lastname: White
authors.forename: J B
authors.initials: JB
authors.lastname: Martin
mesh_terms: D000367:Age Factors; D000368:Aged; D001284:Atrophy; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D008297:Male; D008875:Middle Aged