title: Carbamazepine-lithium toxicity in brain-damaged adolescents.
abstract: For several years carbamazepine has been used to treat intractable mania and it is frequently used in combination with lithium. Reports of toxicity have appeared in the past 2 years and some risk factors have been suggested. This paper reports four cases of brain-damaged adolescents treated with carbamazepine and lithium for both seizure and behaviour control who developed this reported neurotoxic phenomenon.
authors.affiliation: Division of Child Psychiatry, Virginia Treatment Center for Children.
authors.forename: D X
authors.initials: DX
authors.lastname: Parmelee
authors.forename: G J
authors.initials: GJ
authors.lastname: O'Shanick
mesh_terms: D000293:Adolescent; D001925:Brain Damage, Chronic / Q000188:drug therapy*; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D016651:Lithium Carbonate; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced*; D019965:Neurocognitive Disorders / Q000188:drug therapy*; D019966:Substance-Related Disorders / Q000209:etiology
chemical_list: D016651:Lithium Carbonate; D002220:Carbamazepine; D008094:Lithium