[Prevention of postoperative anaerobic bacterial infections in abdominal surgery with metronidazole suppositories].
Metronidazole is widely used for the prevention and treatment of post-operative anaerobic infections. In this study, the prophylactic effectiveness of metronidazole suppositories was tested in patients undergoing abdominal surgery. The suppositories had previously been tested in healthy subjects for drug absorption and tolerance. Patients were divided into three treatment groups: one group received the drug intravenously, another as suppositories and the third one by both routes. Clinical effectiveness was evaluated and plasma metronidazole levels were measured. On the basis of the results obtained, we suggest that a 1 g suppository should be administered 8-hourly over the 20 hours preceding surgery, then 12-hourly if preparation of the digestive tract can be inserted between two administrations. In emergency surgery, 1 suppository must be given at least 1 hour before induction, the 12-hourly, and a 500 mg intravenous infusion at the time of induction.
Bardeau
A
A
Pelletier
A
A
Lefevre
P
P
Farinotti
R
R
Dauphin
A
A
Desmonts
J M
JM
D000005:Abdomen / Q000601:surgery*; D000328:Adult; D000368:Aged; D001421:Bacteria, Anaerobic; D001424:Bacterial Infections / Q000517:prevention & control*; D004630:Emergencies; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D008875:Middle Aged; D010477:Perfusion; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D013488:Suppositories
D013488:Suppositories; D008795:Metronidazole
Prophylaxie des infections postopératoires à germes anaérobies en chirurgie abdominale par les suppositoires de métronidazole.