Adverse reaction of acetaminophen as an alternative analgesic in A.A.S. Triad.
The syndrome of A.A.S. Triad consisting of an intolerance to analgesics such as aspirin, bronchial asthma and nasal polyps, is every day more frequent. During the last years, the use of acetaminophen as an analgesic-antipyretic alternative in patients with A.A.S. Triad has been imperative. However, there are already publications that show reversible bronchial obstruction symptoms similar to the ones produced by A.A.S., though of less intensity. A study was performed in 32 patients diagnosed of A.A.S. Triad by our allergy specialized office with a challenge test of acetaminophen and placebo. Basal spiromentry, physical examination and control of medication before the test, were noted. Of the 32 patients studied, six of them showed a positive provocation test. We maintain the need to perform a provocation test with acetaminophen at the hospital under medical observation before the medication is used by the patient. In terms of practical medicine, this study with acetaminophen as medications of common use in A.A.S. Triad underlies the importance of more caution in prescribing analgesic drugs to patients sensitive to aspirin and A.I.N.E.
Barles
P G
PG
Department of Allergy, University Hospital of Zaragoza, Spain.
Duce García
F
F
Portillo Olmo
J R
JR
Pérez Aznar
J
J
Escuer Alarma
J L
JL
D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D000402:Airway Obstruction / Q000139:chemically induced; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001241:Aspirin / Q000009:adverse effects; D001249:Asthma / Q000139:chemically induced*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000139:chemically induced*
D001095:Arachidonic Acids; D016718:Arachidonic Acid; D000082:Acetaminophen; D001241:Aspirin