[Effect of peripheral vasodilators on the oxygen system of the body and central hemodynamics in patients with acute myocardial infarction].
The effect of nitroglycerin and sodium nitroprusside on arterial and venous blood gases and acid-base state as well as central hemodynamic parameters were assessed in myocardial infarction patients using a micro-Astrup and a rheoplethysmograph. Blood oxygen flow and oxygen uptake were estimated. Nitroglycerin and sodium nitroprusside, administered to myocardial infarction patients showing no signs of heart failure, caused a significant reduction in arterial blood partial oxygen pressure (pO2), which, however, did not lead to a reduction of oxygen flow and tissue oxygen provision. In myocardial infarction patients with heart failure, nitroglycerin and sodium nitroprusside had a favorable effect on systemic oxygen regimen and central hemodynamics.
Nazarov
A M
AM
Pimenova
N N
NN
D000328:Adult; D000368:Aged; D005260:Female; D005292:Ferricyanides / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D005996:Nitroglycerin / Q000627:therapeutic use*; D009599:Nitroprusside / Q000627:therapeutic use*; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000032:analysis
D005292:Ferricyanides; D010108:Oxyhemoglobins; D009599:Nitroprusside; D005996:Nitroglycerin; D010100:Oxygen
Deĭstvie perifericneskikn vazodilatatorov na kislorodnyĭ rezhim organizma i tsentral'nuiu gemodinamiku u bol'nykn ostrym infarktom miokarda.