title: Atriopeptins: renal-specific vasodilators in conscious dogs.
abstract: Conscious dogs were instrumented to study the effects of atriopeptins (I, II, III) on renal, iliac, mesenteric, and coronary blood flow. Intravenous injection of atriopeptins II and III caused a dose-related increase in renal blood flow, whereas atriopeptin I had no effect. Atriopeptins II and III at 5 micrograms/kg increased renal blood flow 27 +/- 5.0% from 252 +/- 29 ml/min and 18 +/- 2.9% from 238 +/- 32 ml/min and reduced renal vascular resistance 24 +/- 3.2% from 0.431 +/- 0.048 mmHg X ml-1 X min and 15.1 +/- 1.2% from 0.443 +/- 0.023 mmHg X ml-1 X min, respectively. Atriopeptin I, II, or III exerted no significant effect on systemic arterial pressure, heart rate, coronary, mesenteric, or iliac blood flows. Doses of nitroglycerin (25 micrograms/kg) that increased renal blood flow (28 +/- 5.0%) to a degree comparable to atriopeptins II and III also caused increases in coronary, iliac, and mesenteric blood flows and produced falls in systemic blood pressure and a reflex tachycardia. Thus in the conscious dog, atriopeptins II and III are potent selective renal vasodilators that do not exhibit systemic hemodynamic effects in contrast to nitroglycerin, a nonselective vasodilator. Cleavage at the carboxy terminal end of these peptides to yield atriopeptin I abolishes the renal vasodilator action entirely.
authors.forename: T H
authors.initials: TH
authors.lastname: Hintze
authors.forename: M G
authors.initials: MG
authors.lastname: Currie
authors.forename: P
authors.initials: P
authors.lastname: Needleman
mesh_terms: D000758:Anesthesia; D000818:Animals; D009320:Atrial Natriuretic Factor; D003243:Consciousness; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D007085:Ilium / Q000098:blood supply; D008643:Mesentery / Q000098:blood supply; D009124:Muscle Proteins / Q000494:pharmacology*; D005996:Nitroglycerin / Q000494:pharmacology; D010424:Pentobarbital; D012079:Renal Circulation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D009124:Muscle Proteins; D014665:Vasodilator Agents; D009320:Atrial Natriuretic Factor; D005996:Nitroglycerin; D010424:Pentobarbital