Effects of long-chain N-acylethanolamines on lipid peroxidation in cardiac mitochondria.
A long-chain N-acylethanolamine (N-oleoyl-2-aminoethanol) is shown to inhibit the production of thiobarbituric acid-reactive substances in rat heart mitochondria treated with Fe2+ or Fe3+/ADP. The inhibition is concentration-dependent in the range 50-150 microM of the agent and can be nearly complete depending on the type and amount of the free radical-generating system. Structural analogues of N-acylethanolamine are inhibitory as well, but neither oleic acid nor ethanol-amine has measurable effects. N-Oleoyl-2-aminoethanol affects peroxidation of linoleic acid micelles only minimally and has no effect on deoxyribose peroxidation.
Parinandi
N L
NL
Hormel Institute, University of Minnesota, Austin 55912.
Schmid
H H
HH
D000818:Animals; D004983:Ethanolamines / Q000494:pharmacology*; D005609:Free Radicals; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013329:Structure-Activity Relationship
D004983:Ethanolamines; D005609:Free Radicals; D008315:Malondialdehyde