Mapping of gene encoding mouse placental alkaline phosphatase to chromosome 4.
The gene encoding the mouse placental alkaline phosphatase (ALP; orthophosphoric-monoester phosphohydrolase, alkaline optimum, EC 3.1.3.1) is mapped to chromosome 4, based on Southern blot hybridization of the mouse cDNA with DNAs from mouse-Chinese hamster somatic cell hybrids. This assignment is consistent with the genetic analysis of the Akp-2 locus, which is responsible for the genetic variation of alkaline phosphatase enzyme in placenta as well as in liver, kidney, and bone.
Terao
M
M
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
Pravtcheva
D
D
Ruddle
F H
FH
Mintz
B
B
D000469:Alkaline Phosphatase / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000235:genetics; D005260:Female; D006822:Hybrid Cells; D051379:Mice; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy
D004247:DNA; D000469:Alkaline Phosphatase