Histomorphometric analysis of epithelial changes in chemically induced oral mucosal carcinogenesis in rats.
Quantitative analysis of rat palatal mucosa after the carcinogen 4- nitroquinoline-1-oxide had been applied to the epithelium for varying periods of time showed that there was a significant increase in epithelial thickness, due largely to an increase in thickness of the basal compartment. This alteration was measurable before epithelial dysplasia could be recognised.
Rich
A M
AM
Department of Dental Medicine and Surgery, University of Melbourne, Australia.
Reade
P C
PC
D015112:4-Nitroquinoline-1-oxide; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology; D002452:Cell Count; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects* / Q000473:pathology; D009062:Mouth Neoplasms / Q000139:chemically induced* / Q000473:pathology; D009600:Nitroquinolines; D010159:Palate; D051381:Rats; D011919:Rats, Inbred Strains
D009600:Nitroquinolines; D015112:4-Nitroquinoline-1-oxide