Post-antibiotic effect induced by ofloxacin in both gram-positive and gram-negative bacteria.
We estimated the relationship of Post Antibiotic Effect (PAE) induced by ofloxacin in both gram-positive and gram-negative bacteria, with the Percent Growth Rate Average (PGRA) considered on an increase of 1 log (CFUs/ml). The results showed a good correlation between parameters (0.84, p less than 0.001), and enabled us to find out that the drug-induced effect persisted after the period of time considered in the standard procedure. Where the values of PAE are much greater, the growth curve rates were faster after the apparent termination of the phenomenon.
Reina
S
S
Institute of Microbiology, University of Genoa, Italy.
Cavallero
A
A
Debbia
E
E
D002470:Cell Survival / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology*
D010078:Oxazines; D015242:Ofloxacin