title: Hyperlipidemia in pediatric patients undergoing peritoneal dialysis.
abstract: We evaluated serial measurements of serum lipid levels in 68 patients aged 12.6 +/- 4.7 years undergoing treatment with continuous ambulatory peritoneal dialysis/continuous cycling peritoneal dialysis (CAPD/CCPD). Fasting mean levels of triglycerides (TG) and cholesterol (C) were elevated above the 95th percentile of published normal values by 102% and 19%, respectively, at the start of dialysis. Except for a short-term decrease in TG levels at 6 and 9 months, no significant change in mean lipid levels was observed during a follow-up period of 2 years. At initiation of dialysis, elevated TG and C levels were present in 90% and 69% of the patients, respectively. The prevalence of hyperlipidemia (HL) varied between 63% and 88% (TG) and 61% and 93% (C), respectively, during the follow-up period. TG and C levels were not correlated with caloric intake (evaluated in 17 patients), serum albumin levels, treatment modality (CAPD or CCPD), a history of the nephrotic syndrome, or previous treatment with hemodialysis or transplantation. However, a significant inverse correlation was observed between age and serum lipids at the initiation of dialysis treatment and after 1 year (TG: r = -0.40; C: r = -0.44). Our data indicate a high prevalence of HL but no significant change of serum lipid levels during 2 years of treatment with CAPD/CCPD.
authors.affiliation: Department of Pediatrics, UCLA School of Medicine 90024.
authors.forename: U
authors.initials: U
authors.lastname: Querfeld
authors.forename: I B
authors.initials: IB
authors.lastname: Salusky
authors.forename: P
authors.initials: P
authors.lastname: Nelson
authors.forename: J
authors.initials: J
authors.lastname: Foley
authors.forename: R N
authors.initials: RN
authors.lastname: Fine
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D002149:Energy Intake; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000628:therapy; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects* / Q000379:methods; D012709:Serum Albumin / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D012709:Serum Albumin; D014280:Triglycerides; D002784:Cholesterol