[Effects of an anti-inflammatory agent of benzamide structure, dexamethasone and indomethacin on experimental cerebral edema induced by phospholipase 2 in rats].
Only a few molecules show any efficacy against brain edema. Different methods such as brain copper-wire implantation or arachidonic acid injection are used in the research of active drugs. A new model, involving injection of phospholipase A2, is described. The effect of an anti-inflammatory compound, N-(4,6-dimethyl 2-pyridinyl) benzamide, was evaluated on the three different experimental brain edemas mentioned above; dexamethasone and indomethacin were used as reference drugs. The studied molecule is, like dexamethasone, active on the three brain edema models. It has no direct inhibitory effect on phospholipase A2, cannot block cyclooxygenase activity but does reduce prostaglandin biosynthesis. Other factors, such as dopaminergic and alpha 2-adrenergic agonist activities, could also interfere.
Juge
M
M
Laboratoire de Pharmacodynamie, U.F.R. des Sciences pharmaceutiques, Nantes.
Petit
J Y
JY
Sanchez
R Y
RY
Pineau
A
A
Welin
L
L
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001095:Arachidonic Acids; D001549:Benzamides / Q000627:therapeutic use*; D001929:Brain Edema / Q000139:chemically induced / Q000188:drug therapy*; D003300:Copper; D003907:Dexamethasone / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D010741:Phospholipases A; D054467:Phospholipases A2; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001095:Arachidonic Acids; D001549:Benzamides; D003300:Copper; D003907:Dexamethasone; C058090:N-(4,6-dimethyl-2-pyridinyl)benzamide; D010741:Phospholipases A; D054467:Phospholipases A2; D007213:Indomethacin
Effets d'un anti-inflammatoire à structure benzamide, de la déxaméthasone et de l'indométacine sur l'oedème cérébral expérimental à la phospholipase A2 chez le rat.