Timing of chemotherapy and surgery in a murine osteosarcoma model.
The sequential use of chemotherapy and surgery in the treatment of osteosarcoma developed in an empirical fashion without the benefit of investigations in animal models. The MGH-OGS murine osteosarcoma is a transplantable tumor that resembles the human disease with respect to histology, local invasiveness, metastatic characteristics, tumor ploidy, and its response to chemotherapy. We have used this tumor model to investigate the efficacy of preoperative, perioperative, and postoperative chemotherapy on the development of pulmonary metastases in three different experimental protocols. In each experimental design, perioperative chemotherapy demonstrated a significant advantage in preventing systemic relapse.
Bell
R S
RS
Sarcoma Biology Laboratory, St. Michael's Hospital, Toronto, Ontario, Canada.
Roth
Y F
YF
Gebhardt
M C
MC
Bell
D F
DF
Rosenberg
A E
AE
Mankin
H J
HJ
Suit
H D
HD
D000818:Animals; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000627:therapeutic use; D007430:Intraoperative Care; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary; D051379:Mice; D009368:Neoplasm Transplantation; D012516:Osteosarcoma / Q000188:drug therapy* / Q000601:surgery; D011003:Ploidies
D004317:Doxorubicin