title: The effects of guanine and cytosine variation on dinucleotide frequency and amino acid composition in the human genome.
abstract: One hundred twelve human DNA sequences were analyzed with respect to dinucleotide frequency and amino acid composition. The variation in guanine and cytosine (G + C) content revealed: (1) at 2-3 and 3-1 doublet positions CG discrimination is attenuated at high G + C, but TA disfavor is enhanced, and (2) several amino acids are subject to G + C change. These findings have been reported in part for collections of sequences from various species. The present study confirms that in a single organism--the human--the G + C effects do exist. Aspects of the argument that connects G + C with protein thermal stability are also discussed.
authors.affiliation: Department of Physics, Faculty of Science, University of Tokyo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Hanai
authors.forename: A
authors.initials: A
authors.lastname: Wada
mesh_terms: D000818:Animals; D003062:Codon; D003596:Cytosine; D005796:Genes; D014644:Genetic Variation; D006147:Guanine; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical
chemical_list: D003062:Codon; D006147:Guanine; D003596:Cytosine