title: Collagen in colorectal cancer in relation to clinicopathologic stage and histologic grade.
abstract: Interstitial collagen is a major constituent of the tumor matrix. The quantity of this protein may influence the prognosis. The collagen content of 54 colorectal tumors, measured as the hydroxyproline concentration in relation to clinicopathologic stage and histologic grade, was investigated and no support for either a negative or positive influence on the prognosis.
authors.affiliation: Department of General Surgery, University Hospital, Nijmegen, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Wobbes
authors.forename: T
authors.initials: T
authors.lastname: Hendriks
authors.forename: H H
authors.initials: HH
authors.lastname: de Boer
mesh_terms: D000230:Adenocarcinoma / Q000032:analysis / Q000473:pathology*; D003094:Collagen / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000032:analysis / Q000473:pathology*; D006801:Humans; D006909:Hydroxyproline / Q000032:analysis; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D003094:Collagen; D006909:Hydroxyproline