Mutagenicity of saccharin in a human cell strain.
The mutagenicity of saccharin was investigated by the phenotypic changes of the sensitivity to ouabain lethality in human RSa cells with high susceptibility to UV mutagenicity. At concentrations ranging from 10.0 to 22.5 mg/ml, saccharin induced a dose-dependent increase in the number of mutations to ouabain resistance. This is the first report, to our knowledge, of saccharin having mutagenic activity in human cells.
Suzuki
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H
Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Suzuki
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N
D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009154:Mutation / Q000187:drug effects* / Q000528:radiation effects; D010042:Ouabain / Q000633:toxicity; D012439:Saccharin / Q000633:toxicity*; D014466:Ultraviolet Rays
D010042:Ouabain; D012439:Saccharin