title: Effects of long-lasting antiepileptic therapy on brainstem auditory evoked potentials.
abstract: The brainstem auditory evoked potentials of 84 epileptic patients in chronic monotherapy with carbamazepine (n = 36), phenobarbital (n = 19), Na-valproate (n = 20) or progabide (n = 9) were studied. The mean values of I-III and I-V interpeak latencies (IPLs) were respectively 2.16 +/- 0.11 and 4.03 +/- 0.17 in the control group, 2.31 +/- 0.09 and 4.17 +/- 0.16 in the valproic group, 2.30 +/- 0.17 and 4.19 +/- 0.20 in the carbamazepine group, 2.17 +/- 0.16 and 4.10 +/- 0.18 in the phenobarbital group and 2.16 +/- 0.11 and 4.12 +/- 0.17 in the progabide group. The prolongation of I-III and I-V IPLs was statistically significant only for the valproic acid and carbamazepine groups. Neither duration of the epilepsy and treatment and frequency of seizures nor the serum drug levels were correlated with I-V IPL values.
authors.affiliation: Scientific Institute H.S. Raffaele, Neurologic Department, University of Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Medaglini
authors.forename: M
authors.initials: M
authors.lastname: Filippi
authors.forename: S
authors.initials: S
authors.lastname: Smirne
authors.forename: L
authors.initials: L
authors.lastname: Ferini-Strambi
authors.forename: M C
authors.initials: MC
authors.lastname: Giusti
authors.forename: A
authors.initials: A
authors.lastname: Poggi
authors.forename: G
authors.initials: G
authors.lastname: Comi
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001933:Brain Stem / Q000187:drug effects*; D002220:Carbamazepine / Q000009:adverse effects; D002648:Child; D004828:Epilepsies, Partial / Q000188:drug therapy*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000009:adverse effects; D011930:Reaction Time / Q000187:drug effects; D014635:Valproic Acid / Q000009:adverse effects; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; C017985:progabide; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D010634:Phenobarbital