[Mechanisms of DNA repair disorders in human cells. Genome instability in lymphocytes of patients with myopathy related to DNA repair disorders].
Increased level of cytogenetic damages was observed in lymphocytes of 10 patients with muscular dystrophy (Duchenne, Erba, Landuzi--Degerin). Analysis of DNA repair synthesis revealed inhibition of this process in lymphocytes of 10 patients observed. On the other hand, decreased reactivation of vaccinia virus and increased level of virus mutagenesis induced by 4-nitroquinoline-1-oxide and bleomycin was noted in the experiments with lymphocytes of 3 patients observed.
Chekova
V V
VV
Plotnikova
N N
NN
L'vova
G N
GN
Valikova
T A
TA
Il'inskikh
N N
NN
D015112:4-Nitroquinoline-1-oxide / Q000633:toxicity; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair; D005796:Genes; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism* / Q000382:microbiology; D009136:Muscular Dystrophies / Q000235:genetics*; D009153:Mutagens; D014616:Vaccinia virus / Q000235:genetics; D014775:Virus Activation / Q000187:drug effects
D009153:Mutagens; D015112:4-Nitroquinoline-1-oxide; D004247:DNA
Mekhanizmy narusheniĭ reparatsii DNK v kletkakh cheloveka. Nestabil'nost' genoma v limfotsitakh bol'nykh miopatiiami, sviazannaia s narusheniem reparatsii DNK.