Uptake of acetylated LDL by peritoneal macrophages obtained from normal and Watanabe heritable hyperlipidemic rabbits, an animal model for familial hypercholesterolemia.
Acetylated low-density lipoprotein (acetyl-LDL) stimulated the incorporation of [14C]oleate into cholesteryl [14C]oleate in peritoneal macrophages from both normal and Watanabe heritable hyperlipidemic (WHHL) rabbits. A degradation study showed that macrophages from WHHL rabbits degraded the same amount of 125I-labeled acetyl-LDL as macrophages from normal rabbits. These findings indicate that macrophages of WHHL rabbits have functional acetyl-LDL receptors.
Ishii
K
K
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
Kita
T
T
Kume
N
N
Nagano
Y
Y
Kawai
C
C
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D015815:Cell Adhesion Molecules; D002478:Cells, Cultured; D002788:Cholesterol Esters / Q000096:biosynthesis; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000235:genetics* / Q000378:metabolism; D006938:Hyperlipoproteinemia Type II; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D011817:Rabbits; D011973:Receptors, LDL / Q000378:metabolism; D051116:Receptors, Scavenger
D015815:Cell Adhesion Molecules; D002788:Cholesterol Esters; D008077:Lipoproteins, LDL; D011973:Receptors, LDL; D051116:Receptors, Scavenger; C032629:acetyl-LDL; C014409:cholesteryl oleate