Quantitation of cardiac messenger RNA in heart-muscle biopsies.
A method has been developed that allows the direct quantitation of cardiac messenger RNA in heart-muscle biopsies. This provides a new tool to directly assess changes in cardiac gene expression in cardiac biopsies. Using this method, we have analyzed changes in cardiac gene expression during induction and regression of triiodothyronine-induced heart hypertrophy, during development of heart atrophy secondary to starvation and protein depletion, in adriamycin cardiomyopathy, and in patients with mitral-valve diseases.
Zähringer
J
J
Pritzl
N
N
Stäb
G
G
Kreuzer
E
E
D000818:Animals; D001284:Atrophy; D001706:Biopsy; D006332:Cardiomegaly / Q000473:pathology; D009202:Cardiomyopathies / Q000473:pathology; D006331:Heart Diseases / Q000473:pathology*; D006801:Humans; D008297:Male; D008944:Mitral Valve Insufficiency / Q000473:pathology; D008946:Mitral Valve Stenosis / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D010210:Papillary Muscles / Q000473:pathology; D011061:Poly A / Q000378:metabolism; D011072:Poly U / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D012333:RNA, Messenger; D011061:Poly A; D011072:Poly U