title: Effect of isotretinoin on eccrine gland function.
abstract: Sweat secretion rate, stimulated by iontophoresis of pilocarpine, was measured before and during treatment with isotretinoin in 20 patients. Sweat secretion was increased during treatment in 15 patients (75%), but the mean increase of 15% was not statistically significant (P = 0.085, paired t-test; 95% confidence limits-0.2% to +30%) and no patients had a clinically apparent alteration of sweating. We conclude that there is no important change in stimulated sweating associated with isotretinoin therapy.
authors.affiliation: Department of Dermatology, Royal Victoria Infirmary, Newcastle-upon-Tyne, U.K.
authors.forename: J L
authors.initials: JL
authors.lastname: Rees
authors.forename: N H
authors.initials: NH
authors.lastname: Cox
mesh_terms: D000293:Adolescent; D000328:Adult; D004439:Eccrine Glands / Q000187:drug effects*; D005260:Female; D006801:Humans; D015474:Isotretinoin; D008297:Male; D013545:Sweat Glands / Q000187:drug effects*; D013546:Sweating / Q000187:drug effects; D014212:Tretinoin / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D014212:Tretinoin; D015474:Isotretinoin