Laminin: molecular organization and biological function.
Laminin, the most abundant glycoprotein molecule found in basement membrane, has multiple functions in eukaryotic tissues. It serves to attach epithelial cells to basement membrane, aids development and migration of specific cell types in growth and maturation, and has been implicated in tumor metastasis and some types of infection. Current concepts of the molecular organization and myriad functions of the laminin molecule are reviewed.
Campbell
J H
JH
Department of Oral Biology, SUNY, Buffalo 14214.
Terranova
V P
VP
D000818:Animals; D001422:Bacterial Adhesion; D001695:Biology; D014408:Biomarkers, Tumor; D002468:Cell Physiological Phenomena; D007797:Laminin / Q000502:physiology* / Q000627:therapeutic use; D011487:Protein Conformation; D014945:Wound Healing
D014408:Biomarkers, Tumor; D007797:Laminin