Comparison of sublingual lorazepam with intramuscular diazepam as sedatives during oral surgery.
Sublingual lorazepam (2 to 3 mg) was compared with intramuscular diazepam (0.25 mg/kg) and placebo for sedation during oral surgery under local anesthesia. Sixty patients were randomly allocated into three groups in this double-blind, parallel study. The results from this trial show that sublingually administered lorazepam provided good sedation and anxiolysis. More side-effects, such as giddiness, dizziness, and ptosis, as well as profound and prolonged psychomotor impairment, were, however, found in the lorazepam group than in those patients who had received intramuscular diazepam (0.25 mg/kg) or placebo.
van der Bijl
P
P
Department of Oral Medicine and Periodontics, Faculty of Dentistry, University of Stellenbosch, Tygerberg, South Africa.
Roelofse
J A
JA
Joubert
J J
JJ
D000286:Administration, Sublingual; D000293:Adolescent; D000328:Adult; D003975:Diazepam / Q000008:administration & dosage* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008140:Lorazepam / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D011229:Preanesthetic Medication; D011897:Random Allocation; D013223:Statistics as Topic; D013607:Tablets; D014081:Tooth Extraction
D013607:Tablets; D008140:Lorazepam; D003975:Diazepam