Action of lead(II) and aluminium (III) ions on iron-stimulated lipid peroxidation in liposomes, erythrocytes and rat liver microsomal fractions.
Lead (Pb2+) ions accelerate the lipid peroxidation observed when Fe2+ ions are added to phospholipid liposomes at pH 5.5 or pH 7.4, although Pb2+ ions alone do not induce any peroxidation. Similarly, aluminium (Al3+) ions increase Fe2+-dependent liposomal peroxidation at pH 5.5. Both Pb2+ and Al3+ accelerate the peroxidation of erythrocytes induced by high concentrations of H2O2 in the presence of azide, and they also increase the peroxidation that occurs when Fe2+ or Fe2+-ADP is added to rat liver microsomes at pH 7.4. It is proposed that increased lipid peroxidation may contribute to the toxic actions of Pb2+ in humans.
Quinlan
G J
GJ
National Institute for Biological Standards and Control, London, U.K.
Halliwell
B
B
Moorhouse
C P
CP
Gutteridge
J M
JM
D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D002412:Cations; D004912:Erythrocytes / Q000378:metabolism*; D005296:Ferrous Compounds; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007854:Lead / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats
D002412:Cations; D005296:Ferrous Compounds; D008054:Lipid Peroxides; D008081:Liposomes; D007854:Lead; D000535:Aluminum