Pharmacokinetics of human recombinant interferon-alpha I after i.v. infusion and im injection in African green monkeys.
The pharmacokinetics of recombinant human interferon-alpha I (rHuIFN-alphaI) were studied following a single 3 X 10(6) U/kg dose administered as a 30-min intravenous (iv) infusion and as an intramuscular (im) injection to four African green monkeys using a crossover design. Concentrations of rHuIFN-alpha I in serum were determined by bioassay. Serum rHuIFN-alpha I concentrations declined rapidly following an iv infusion. The elimination half-life ranged from 1.7 to 2.0 h. The volume of distribution at steady state and the total body clearance ranged from 0.42 to 2.4 L/kg and 28 to 233 ml/min, respectively. A protracted absorption profile was seen following im injection, with a highly variable bioavailability ranging from 16 to 680%, compared with the iv infusion. The overall disposition of rHuIFN-alpha I is comparable to that of rHuIFN-alpha A and other IFNs in monkeys.
Wills
R J
RJ
Hoffmann-La Roche Inc., Nutley, NJ 07110.
Soike
K F
KF
D000818:Animals; D002522:Chlorocebus aethiops; D006801:Humans; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D007370:Interferon Type I / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D011994:Recombinant Proteins
D007370:Interferon Type I; D011994:Recombinant Proteins