title: [Comparative in vitro antistaphylococcal effect of norfloxacin and pefloxacin on 312 hospital strains].
abstract: Antistaphylococcal activity of two new quinolones, norfloxacin and pefloxacin, was studied. Minimal inhibitory concentrations (MICs) were determined by the agar dilution technique for 312 staphylococcal strains, all of which were resistant to nalidixic acid. 50% and 90% MICs were respectively 1 and 4 micrograms/ml for norfloxacin and 0.5 and 1 micrograms/ml for pefloxacin. Activities of these two new quinolones proved similar on Staphylococcus aureus and non-coagulase-producing staphylococci, regardless of their response to methicillin. Cross resistance between the two drugs was demonstrated.
authors.forename: E
authors.initials: E
authors.lastname: Ronco
authors.forename: J
authors.initials: J
authors.lastname: Pilliot
mesh_terms: D003030:Coagulase / Q000378:metabolism; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D009643:Norfloxacin; D015366:Pefloxacin; D010403:Penicillin Resistance; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D003030:Coagulase; D015366:Pefloxacin; D009268:Nalidixic Acid; D009643:Norfloxacin; D008712:Methicillin
vernacular_title: Activité antistaphylococcique comparée in vitro de la norfloxacine et de la péfloxacine sur 312 souches hospitaliéres.