Histological aspects of Campylobacter pylori colonisation and infection of gastric and duodenal mucosa.
The main features of the histopathology of Campylobacter pylori-associated gastritis are reviewed. The organism is strongly associated with the Type B pattern of chronic gastritis. It colonizes the abnormal antrum and is not usually seen on the normal mucosa. However it fails to colonize the abnormal antrum in the Type A gastritis of pernicious anaemia. When present in the duodenum it is in conjunction with severe duodenitis and gastric metaplasia. Although the organisms are present in over 70% of patients with peptic ulcer disease care must still be taken with identification, as other gastric spiral organisms can be present that are not Campylobacters.
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Department of Pathology, Northwick Park Hospital, Harrow, Middlesex, England.
D002167:Campylobacter / Q000254:growth & development*; D002169:Campylobacter Infections / Q000382:microbiology / Q000473:pathology*; D002908:Chronic Disease; D004378:Duodenal Diseases / Q000382:microbiology / Q000473:pathology*; D004382:Duodenitis / Q000382:microbiology; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000145:classification / Q000209:etiology; D006801:Humans; D008679:Metaplasia; D011706:Pyloric Antrum / Q000382:microbiology; D013272:Stomach Diseases / Q000382:microbiology / Q000473:pathology*