Stimulated lymphoid cells of B lineage, but not plasma or myeloid cells, can express E receptor.
After culture with 20-30% autologous or allogeneic T cells and PHA, at least a proportion of the pathological cells from a variety of B-cell proliferations (common acute lymphoblastic leukaemia, prolymphocytic leukaemia, non-Hodgkin's lymphoma with blood involvement by mature lymphoid (cleaved and non-cleaved) cells) expressed true endogenous sheep erythrocyte (E) receptors. In contrast, plasma cells and a variety of myeloid cells failed to express E receptors after similar in vitro stimulation. These data, taken in conjunction with previous findings with B cells from normals and patients with hairy-cell and chronic lymphocytic leukaemia, suggest that B cells earlier than plasma cells can express E receptors after appropriate stimulation. The findings provide an in vitro counterpart of the leukaemic proliferations expressing both E receptor and surface immunoglobulin described from various laboratories, and further question the lineage specificity of the E receptor.
Mills
K H
KH
Cawley
J C
JC
D000818:Animals; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D004912:Erythrocytes / Q000276:immunology*; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000276:immunology*; D007945:Leukemia, Lymphoid / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000276:immunology; D008223:Lymphoma / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D009101:Multiple Myeloma / Q000276:immunology; D015260:Neprilysin; D010950:Plasma Cells / Q000276:immunology*; D011971:Receptors, Immunologic / Q000276:immunology*; D012397:Rosette Formation; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D011971:Receptors, Immunologic; D015260:Neprilysin