title: The effect of mismatching and sharing of HLA-A, -B, and -DR antigens on kidney graft survival in Eurotransplant 1982 to 1988.
abstract: 1. Cyclosporine significantly improved kidney graft survival by 10-15%. 2. Matching for HLA-DR, HLA-B + DR and HLA-A + B + DR improved kidney graft survival significantly in non-CsA-treated patients. 3. Matching for the HLA-A, -B, and -DR loci, apart and in combination, significantly improved kidney graft survival in CsA-treated patients. 4. The best kidney graft survival was observed in HLA-A + B + DR identical combinations treated with CsA (76% at 5 yrs).
authors.affiliation: Eurotransplant Foundation, University of Leiden, The Netherlands.
authors.forename: G G
authors.initials: GG
authors.lastname: Persijn
authors.forename: J
authors.initials: J
authors.lastname: D'Amaro
authors.forename: P
authors.initials: P
authors.lastname: De Lange
authors.forename: G M
authors.initials: GM
authors.lastname: Schreuder
authors.forename: J
authors.initials: J
authors.lastname: Thorogood
authors.forename: F
authors.initials: F
authors.lastname: Zantvoort
authors.forename: J J
authors.initials: JJ
authors.lastname: Van Rood
mesh_terms: D003524:Cyclosporins / Q000627:therapeutic use; D005060:Europe / Q000453:epidemiology; D006085:Graft Survival; D006680:HLA Antigens / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D016030:Kidney Transplantation / Q000276:immunology* / Q000401:mortality / Q000706:statistics & numerical data; D015993:Life Tables; D010043:Outcome and Process Assessment, Health Care; D016019:Survival Analysis; D015996:Survival Rate
chemical_list: D003524:Cyclosporins; D006680:HLA Antigens