Adriamycin, aclacinomycin and thepirubicin intracardiac distribution examined by fluorescence microscopy.
Male Wistar rats received adriamycin, aclacinomycin or thepirubicin at a dose of 4 mg/kg b.w. by slow infusion. Cardiac tissue sections were examined by fluorescence microscopy to evaluate the distribution of the three anthracyclines. The nuclei regularly exhibited a stronger coloring with respect to the cytoplasm for all three drugs. Adriamycin cytoplasm fluoresced intensely, unlike aclacinomycin and thepirubicin. Our results indicate a lower uptake of these last two molecules into cardiac tissue, thus suggesting a different pharmacokinetic profile which might account for their lower cardiotoxicity.
Scalori
V
V
Institute of Pharmacology, University of Pisa, Italy.
Alessandrì
M G
MG
Giovannini
L
L
Bertelli
A A
AA
Mian
M
M
D015250:Aclarubicin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000493:pharmacokinetics*; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D008297:Male; D008856:Microscopy, Fluorescence; D009206:Myocardium / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D000903:Antibiotics, Antineoplastic; C011157:aclacinomycins; D015250:Aclarubicin; D004317:Doxorubicin; C027260:pirarubicin