Chalone-like inhibition of DNA synthesis in helminths.
Chalone-like inhibitory activity was found in extracts from tissues of Taenia crassiceps cysticercus and tissues of adult Ascaris suum. The inhibitory effects were partially species nonspecific: The extracts from T. crassiceps larvae inhibit both T. crassiceps and Mesocestoides corti larvae DNA synthesis. Extracts from A. suum, however, inhibit only T. crassiceps. Besides them, the inhibitory factor from mouse brain inhibits both T. crassiceps and M. corti DNA synthesis. When the inhibitory factor from A. suum was applied 4 times during 24-hr culture (at 6-hr intervals), the inhibitory effect was decreased.
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D000818:Animals; D001200:Ascaris / Q000032:analysis; D001923:Brain Chemistry; D002589:Cestoda / Q000187:drug effects* / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D003864:Depression, Chemical; D006131:Growth Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D013621:Taenia / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D014020:Tissue Extracts
D006131:Growth Inhibitors; D014020:Tissue Extracts; D004247:DNA