A new specific chromosomal rearrangement, t(11;20)(p15;q11), in myeloblastic leukemia with maturation.
The translocation t(11;20)(p15;q11) was found as the sole acquired clonal chromosome abnormality in two patients with acute myeloid leukemia. The bone marrow morphology in both cases corresponded to the M2 subtype of the French-American-British (FAB) classification. None of the patients achieved complete remission, and both died less than 6 months after diagnosis. This particular translocation has not previously been reported in acute nonlymphocytic leukemia.
Mitelman
F
F
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Prigogina
E L
EL
Fleischman
E W
EW
Frenkel
M A
MA
Garwicz
S
S
Heim
S
S
Ilyinskaya
G W
GW
Kristoffersson
U
U
Mandahl
N
N
Volkova
M A
MA
D000293:Adolescent; D002880:Chromosomes, Human, Pair 11; D002884:Chromosomes, Human, Pair 15; D002890:Chromosomes, Human, Pair 20; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic