In vitro activity of temocillin against Neisseria gonorrhoeae including penicillinase-producing strains.
169 penicillinase-producing strains of Neisseria gonorrhoeae (PPNG) isolated in the United Kingdom were examined for susceptibility to temocillin and spectinomycin. A further 25 PPNG strains and 214 non-penicillinase-producing strains were examined against temocillin, spectinomycin, amoxycillin, cefuroxime and penicillin. Minimum inhibitory temocillin concentrations ranged from 0.36 to 5.0 mg/L with a mode at 1.25 mg/L. The distributions of sensitivities to other agents were in keeping with those previously described.
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D000658:Amoxicillin / Q000494:pharmacology; D002444:Cefuroxime / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006069:Gonorrhea / Q000382:microbiology; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects*; D010405:Penicillinase / Q000378:metabolism; D010406:Penicillins / Q000494:pharmacology*; D000198:Spectinomycin / Q000494:pharmacology
D010406:Penicillins; C031367:temocillin; D000658:Amoxicillin; D000198:Spectinomycin; D010405:Penicillinase; D002444:Cefuroxime