title: Combined bone marrow and gallium imaging. Differentiation of osteomyelitis and infarction in sickle hemoglobinopathy.
abstract: The clinical records and scintigrams of patients with sickle hemoglobinopathy who underwent combined Tc-99m bone marrow imaging and Ga-67 imaging to differentiate osteomyelitis from bony infarction were reviewed. Of 18 paired examinations in 15 patients, osteomyelitis was diagnosed correctly in six cases; in all six, gallium uptake at the symptomatic site was incongruently increased relative to the bone marrow activity. Of the 12 episodes of infarction, 11 showed congruent activity on both Tc-99m and Ga-67 images. The remaining study was interpreted incorrectly as osteomyelitis due to incongruent Tc-99m and Ga-67 uptake. The use of sequential Tc-99m bone marrow and Ga-67 imaging is an effective means of distinguishing osteomyelitis from bony infarction in patients with sickle hemoglobinopathy.
authors.affiliation: Department of Radiology, University of Chicago Medical Center, Illinois 60637.
authors.forename: C E
authors.initials: CE
authors.lastname: Kahn
authors.forename: J W
authors.initials: JW
authors.lastname: Ryan
authors.forename: M K
authors.initials: MK
authors.lastname: Hatfield
authors.forename: W B
authors.initials: WB
authors.lastname: Martin
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000000981:diagnostic imaging*; D001853:Bone Marrow / Q000000981:diagnostic imaging*; D001842:Bone and Bones / Q000098:blood supply*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005710:Gallium Radioisotopes; D006801:Humans; D007223:Infant; D007238:Infarction / Q000000981:diagnostic imaging*; D010019:Osteomyelitis / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D005710:Gallium Radioisotopes; D013668:Technetium Tc 99m Aggregated Albumin; D013671:Technetium Tc 99m Sulfur Colloid