MPA plasma levels after oral administration in gastrectomized cancer patients during chemotherapy.
Five patients (3 females; 2 males) who underwent gastrectomy for carcinoma were administered adjuvant chemotherapy and high dose medroxyprogesterone acetate (HD-MPA) as supportive therapy. MPA administered p.o. was regularly absorbed; the drug was well tolerated and was almost lacking in toxicity. MPA, thanks to its myeloprotective activity and its anabolic effects, can be used as supportive therapy in the treatment of a wide range of malignancies.
Fornasiero
A
A
Daniele
O
O
Fosser
V
V
Morandi
P
P
Fiorentino
M V
MV
D000230:Adenocarcinoma / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D017258:Medroxyprogesterone Acetate; D008660:Metabolism / Q000187:drug effects; D013274:Stomach Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000601:surgery
D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone