[Method of efficacious immunization against syngeneic murine sarcoma].
C57BL mice are immunized by subcutaneous injection of the T2 syngeneic tumour (MCA fibrosarcoma), followed a week later by surgical removal of the tumour. Such mice can be made hyper-immune by challenging them with mitomycin C-treated T2 cells and they do not develop a tumour after a subsequent inoculum of live T2 cells. Lymph nodes near the site of tumour inoculation are removed after 2 weeks and histological studies show an increase in the number of macrophages and mast cells but not of Lyt-2+ lymphocytes.
Schaaf-Lafontaine
N
N
Maquet
P
P
De Graef-Lovens
D
D
Courtoy
R
R
Firket
H
H
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D005354:Fibrosarcoma / Q000276:immunology*; D006084:Graft Rejection; D007114:Immunization / Q000379:methods*; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology*; D008264:Macrophages / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology
D000951:Antigens, Neoplasm
Mise au point d'une procédure d'immunisation efficace contre un sarcome murin syngénique.