[Hemodynamic and respiratory effects of the perfusion of low-dose endotoxin in intact heparinized dogs].
In the anesthetized dog, a low dose perfusion of endotoxin (50 ng X kg-1 X min-1) produces hemodynamic and metabolic perturbations generally similar to those clinically found in man during the hemodynamic phase of septic shock. These modifications are observed after about 30 minutes following the beginning of the perfusion. They constitute: 1) an arterial vasodilatation responsible for a hypotension without a significant modification of the cardiac output; 2) a drop in the left ventricular filling pressure; 3) a progressive metabolic acidosis; 4) a moderate arterial hypoxia that is independent of an alveolar hypoventilation. To these perturbations is added the contemporary development of a leucopenia associated with a thrombopenia. This mode of endotoxin administration seems to us to constitute a satisfactory experimental model for studying the circulatory injuries due to hyperdynamic septic shock.
D'Orio
V
V
Hay
F
F
Fossion
A
A
Juchmes
J
J
Ferir
A
A
Marcelle
R
R
Limet
R
R
D000818:Animals; D004285:Dogs; D004731:Endotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology; D010477:Perfusion; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors
D004731:Endotoxins; D006493:Heparin
Effets hémodynamiques et respiratoires de la perfusion de faibles doses d'endotoxine chez le chien intact hépariné.