title: [Fundamental and clinical study on cefuzonam in the field of obstetrics and gynecology].
abstract: Cefuzonam (L-105, CZON), a new beta-lactam antibiotic, was studied for its transfer into intrapelvic tissues and for clinical efficacy in the treatment of obstetrical and gynecological infection. 1. Following an intravenous 1 hour drip infusion of 1 g, the transferred CZON into uterine tissues reached and was maintained at effective concentrations which were defined as levels exceeding MICs against clinical isolates frequently obtained from patients in the field of obstetrics and gynecology. The peak concentration of CZON in the pelvic dead space exudate was estimated to be 20 micrograms/ml at 0.5-1 hour after infusion. 2. Subjects studied were 5 patients with the following infections: pyometra (3 cases), puerperal intrauterine infection (1 case), vaginal cuff infection (1 case). Clinical efficacies were good in 4 cases and poor in 1 case. No notable side effects or abnormal laboratory test results were noted.
authors.affiliation: Department of Obstetrics and Gynecology, Fukuyama National Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Hirabayashi
authors.forename: E
authors.initials: E
authors.lastname: Okada
mesh_terms: D000290:Adnexa Uteri / Q000378:metabolism*; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy* / Q000378:metabolism; D015296:Ceftizoxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D014591:Uterine Diseases / Q000188:drug therapy* / Q000378:metabolism; D014599:Uterus / Q000378:metabolism*
chemical_list: C049934:cefuzonam; D015296:Ceftizoxime