Potential prodrugs of phenelzine: N2-acetylphenelzine and N2-ethoxycarbonylphenelzine.
This report describes experiments conducted to determine whether simple monoacylated analogues of phenelzine might act as prodrug sources of phenelzine in vivo. The data suggest that hydrolysis to phenelzine may vary between analogues and that not all analogues retain the pharmacological properties of phenelzine.
Danielson
T J
TJ
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
Coutts
R T
RT
Baker
G B
GB
Chan
M C
MC
D000818:Animals; D001921:Brain / Q000201:enzymology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008996:Monoamine Oxidase Inhibitors; D009043:Motor Activity / Q000187:drug effects; D010624:Phenelzine / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D011355:Prodrugs
D008996:Monoamine Oxidase Inhibitors; D011355:Prodrugs; C043198:N-acetylphenelzine; C057281:N(2)-ethoxycarbonylphenelzine; D010624:Phenelzine