title: Siderophore production by the pathogenic yeast, Candida albicans.
abstract: Biochemical assays were used to determine that some strains of Candida albicans were capable of simultaneous secretion of both the hydroxamate and phenolate-type siderophores when grown in a deferrated medium at 37 degrees C. All isolants of C. albicans released hydroxamate-type siderophores into the culture medium; whereas, approximately 40% of the strains simultaneously secreted phenolate-type siderophores. The presence of phenolate and hydroxamate-type siderophores in the culture medium was further confirmed by assaying the culture media with type specific siderophore-dependent bacterial auxotrophs. This is the first report showing production of both classes of siderophores by a pathogenic yeast.
authors.forename: A
authors.initials: A
authors.lastname: Ismail
authors.forename: G W
authors.initials: GW
authors.lastname: Bedell
authors.forename: D M
authors.initials: DM
authors.lastname: Lupan
mesh_terms: D001173:Arthrobacter / Q000187:drug effects; D001681:Biological Assay; D002176:Candida albicans / Q000378:metabolism*; D006877:Hydroxamic Acids / Q000032:analysis; D062385:Hydroxybenzoates / Q000032:analysis; D007502:Iron Chelating Agents / Q000096:biosynthesis*; D010618:Phenanthrolines / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000187:drug effects; D017262:Siderophores; D013053:Spectrophotometry
chemical_list: D006877:Hydroxamic Acids; D062385:Hydroxybenzoates; D007502:Iron Chelating Agents; D010618:Phenanthrolines; D017262:Siderophores; C017616:phenolic acid; C025205:1,10-phenanthroline