Effects of a synthetic human atrial natriuretic polypeptide on regional blood flow in rats.
The effects of alpha-hANP on systemic hemodynamics and regional blood flow were examined in conscious WKY and SHR. An intravenous infusion of alpha-hANP (3 micrograms/kg per min) resulted in a rapid and marked fall of blood pressure and of total peripheral resistance but with no change in cardiac output in both strains. alpha-hANP decreased vascular resistance in most organs and there was a redistribution of renal blood flow. Thus, the acute hypotensive effect of alpha-hANP is probably related to a vasodilator action.
Fujioka
S
S
Tamaki
T
T
Fukui
K
K
Okahara
T
T
Abe
Y
Y
D000818:Animals; D009320:Atrial Natriuretic Factor; D004232:Diuretics / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009124:Muscle Proteins / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012039:Regional Blood Flow / Q000187:drug effects; D012079:Renal Circulation / Q000187:drug effects
D004232:Diuretics; D009124:Muscle Proteins; D009320:Atrial Natriuretic Factor