Action of cyclooxygenase (COX) and lipoxygenase (LOX) inhibitors as well as of oxygen free radical scavengers (OFRS) in the inflammation-induced vasodepression.
Vasoprotective activity of COX inhibitors (diclofenac, piroxicam, indomethacin, aspirin) and of LOX inhibitors (nordihydroguaiaretic acid, propyl gallate, oxphaman) or of both (BW 755c) as well as of OFRS (mannitol, ethanol, thiourea, vitamin E) was investigated ex vivo in the isolated perfused hindlegs of the animals after in vivo u.v.-irradiation and antigen-provocation in mice and rats, respectively. The results show that vasodepression is mainly prevented by OFRS, antioxidants/LOX inhibitors and aspirin, but not by other COX inhibitors.
Kuhn
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C
Dept. of Pharmacology, Martin Luther University, GDR, Halle.
Bekemeier
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H
Hirschelmann
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R
Giessler
A J
AJ
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D016861:Cyclooxygenase Inhibitors; D004487:Edema / Q000188:drug therapy*; D004890:Erythema / Q000188:drug therapy*; D005260:Female; D005609:Free Radicals; D006614:Hindlimb / Q000098:blood supply; D066298:In Vitro Techniques; D007249:Inflammation / Q000503:physiopathology*; D016859:Lipoxygenase Inhibitors; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011832:Radiation Injuries / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000528:radiation effects; D014655:Vascular Resistance / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D005609:Free Radicals; D016859:Lipoxygenase Inhibitors