Syntheses and complement inhibitory activities of 4-(2-phenyl-1H-indol-3-yl)cyclohexane-1-carboxylic acids.
The syntheses of 4-(2-phenyl-1H-indol-3-yl)cyclohexane-1-carboxylic acids are described. These compounds express potent in vitro inhibition of the human classical complement pathway, and qualitative SAR have been determined. Several of the in vitro active compounds also suppressed the complement dependent reverse passive Arthus reaction (RPAR) in guinea pigs.
Bailey
D M
DM
DeGrazia
G D
GD
Alexander
E J
EJ
Powles
R G
RG
Johnson
R E
RE
Patrick
R A
RA
Heerdt
B G
BG
Fairbain
M E
ME
Pruden
D J
DJ
D000818:Animals; D001183:Arthus Reaction; D003169:Complement Inactivator Proteins / Q000138:chemical synthesis*; D003171:Complement Pathway, Classical / Q000187:drug effects; D003509:Cyclohexanecarboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D006461:Hemolysis; D006801:Humans; D008297:Male; D013237:Stereoisomerism
D003169:Complement Inactivator Proteins; D003509:Cyclohexanecarboxylic Acids