Blood coagulation studies in guineapigs (Cavia porcellus).
Blood coagulation studies were performed on 45 healthy, adult guinea pigs. Additionally thrombelastograms of 30 animals were recorded. Guineapigs revealed short partial thromboplastin times and euglobulin lysis times, but long prothrombin times and thrombin times. Fibrinogen values were within the range of human normal values. Biphasic ADP-induced aggregation of platelets, as occurs in man, was found in 29% of the animals. Short r (reaction time until the beginning of clot formation) and k times (time from the beginning of clot formation until an amplitude of 20 mm) of their thrombelastograms indicate, that whole blood clotting is enhanced in guineapigs. Higher maximum amplitudes in this species suggest a stronger clot stability than in man.
Kaspareit
J
J
Institut für Pathologie, Abteilung Versuchstierpathologie, Tiermedizinische Hochschule Hannover, FRG.
Messow
C
C
Edel
J
J
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001777:Blood Coagulation; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D006168:Guinea Pigs / Q000097:blood*; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D010974:Platelet Aggregation / Q000187:drug effects; D011517:Prothrombin Time; D012016:Reference Values; D012712:Serum Globulins / Q000378:metabolism; D013916:Thrombelastography; D013918:Thrombin Time
D012712:Serum Globulins; D000244:Adenosine Diphosphate; D005340:Fibrinogen