title: Combined linkage and segregation analysis using regressive models.
abstract: Regressive models for segregation analysis have been extended to include multivariate data and linked marker loci. The new models have been applied to data from two pedigrees segregating a gene for cardiovascular disease.
authors.affiliation: Division of Biostatistics, Howard University Cancer Center, Washington, DC.
authors.forename: G E
authors.initials: GE
authors.lastname: Bonney
authors.forename: G M
authors.initials: GM
authors.lastname: Lathrop
authors.forename: J M
authors.initials: JM
authors.lastname: Lalouel
mesh_terms: D001055:Apolipoproteins B / Q000097:blood / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006937:Hypercholesterolemia / Q000235:genetics; D006995:Hypobetalipoproteinemias / Q000235:genetics; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D010641:Phenotype; D011973:Receptors, LDL / Q000235:genetics
chemical_list: D001055:Apolipoproteins B; D005819:Genetic Markers; D011973:Receptors, LDL