title: Steroid and steroid regulating hormones in human male castrates.
abstract: Testosterone, dihydrotestosterone, androstenedione, dehydroepiandrosterone and its sulphate, 11 beta-hydroxyandrostenedione, 17 alpha-hydroxyprogesterone, cortisol, LH, FSH and sex hormone binding globulin (SHBG) were determined in 16 otherwise healthy male castrates, orchidectomized for the forensic reasons. Their hormone levels were compared with those, obtained in normal males of the same age category. There were found in the castrates decreased levels of testosterone, dihydrotestosterone, dehydroepiandrosterone sulphate and androstenedione, unaltered concentrations of cortisol and dehydroepiandrosterone, whereas the levels of 11 beta-hydroxyandrostenedione, 17 alpha-hydroxyprogesterone, both gonadotrophins and SHBG were increased. The results point to the importance of the selective increase of the incretory activity of the adrenal cortex in situations, when the gonadal function is impaired or missing.
authors.affiliation: Research Institute of Endocrinology, Charles University, School of Medicine, Prague, Czechoslovakia.
authors.forename: R
authors.initials: R
authors.lastname: Hampl
authors.forename: J
authors.initials: J
authors.lastname: Zvĕrina
authors.forename: J
authors.initials: J
authors.lastname: Sulcová
authors.forename: L
authors.initials: L
authors.lastname: Stárka
mesh_terms: D000302:Adrenal Cortex / Q000502:physiology*; D000328:Adult; D000728:Androgens / Q000097:blood* / Q000502:physiology; D015415:Biomarkers; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000097:blood / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D012463:Saliva / Q000378:metabolism; D012738:Sex Hormone-Binding Globulin / Q000097:blood; D013739:Testosterone / Q000097:blood / Q000378:metabolism / Q000502:physiology
chemical_list: D000728:Androgens; D015415:Biomarkers; D006062:Gonadotropins; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D006854:Hydrocortisone