title: Chromosome studies on 30 Chinese patients with acute nonlymphocytic leukemia in Taiwan.
abstract: Cytogenetic studies were performed on 32 consecutive Chinese patients with de novo acute nonlymphocytic leukemia (ANLL) in Taiwan. Of the 30 patients with adequate specimens, 20(66%) had clonal chromosome abnormalities. Structural rearrangements were detected in 18 of them. Seven (four were children) of the 16 patients with M2 ANLL had t(8;21). All six patients with acute promyelocytic leukemia (APL; M3 subtype) had t(15;17). Two patients with M4 type leukemia and abnormal bone marrow eosinophils had inv(16)(p13q22). Another M4 patient with a mild increase of morphologically normal eosinophils in the bone marrow had an abnormal chromosome #16, t(1;16)(q21;p13) in which 16q22 was not involved. One patient with M5 ANLL had t(9;11). Only two patients had a numerical change as the sole abnormality. None of the patients had loss or deletion of chromosome #5 or loss of chromosome #7, and only one had a deletion of 7q. This study revealed a high incidence of t(8;21), t(15;17), and a low incidence of -5/5q- or -7/7q- in Chinese patients with ANLL.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China.
authors.forename: H F
authors.initials: HF
authors.lastname: Tien
authors.forename: C H
authors.initials: CH
authors.lastname: Wang
authors.forename: F Y
authors.initials: FY
authors.lastname: Lee
authors.forename: S M
authors.initials: SM
authors.lastname: Chuang
authors.forename: Y C
authors.initials: YC
authors.lastname: Chen
authors.forename: D T
authors.initials: DT
authors.lastname: Lin
authors.forename: M C
authors.initials: MC
authors.lastname: Shen
authors.forename: C H
authors.initials: CH
authors.lastname: Liu
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D013624:Taiwan
chemical_list: D005819:Genetic Markers