Intravenous nitroglycerin as a means of improving ischemic tissue hemodynamics and survival.
The effects of intravenous nitroglycerin infusion on experimental skin flap survival and fluorescein dye kinetics were studied in animals. Perfusion fluorometry was utilized to examine changes in flap hemodynamics and viability. An improvement in skin flap survival was found in the nitroglycerin-infused animals, whether the nitroglycerin was initiated 30 minutes before or 30 minutes after flap elevation. Dye elimination in the flap appeared to be significantly improved with the drug therapy, indicating an improvement in flap blood flow with nitroglycerin.
Gatti
J E
JE
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia 19104.
Brousseau
D A
DA
Silverman
D G
DG
LaRossa
D
D
D000818:Animals; D005470:Fluorometry; D006085:Graft Survival / Q000187:drug effects*; D007262:Infusions, Intravenous; D007511:Ischemia / Q000503:physiopathology*; D005996:Nitroglycerin / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000098:blood supply*; D013524:Surgical Flaps / Q000502:physiology*
D005996:Nitroglycerin