Photoradiation therapy of endobronchial lung cancer. Large obstructing tumors, nonobstructing tumors, and early-stage bronchial cancer lesions.
Photoradiation (photodynamic) therapy of endobronchial primary and metastatic lung cancers uniformly results in a complete response--that is, the opening up of totally or partially obstructed bronchi to their walls. The method, employing hematoporphyrin derivative and red laser light from an argon-pumped dye laser, is safe, efficient, and effective. The safety and lack on any complications rest upon the use of light-diffusing cylinder tips, and upon clean-up bronchoscopy to remove tumor debris promptly. The trachea and main and lobar bronchi, as well as segmental and subsegmental bronchi, can be entirely freed of tumor and completely opened up.
Balchum
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Doiron
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D000328:Adult; D000368:Aged; D001999:Bronchoscopy; D002283:Carcinoma, Bronchogenic / Q000188:drug therapy* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000627:therapeutic use*; D006801:Humans; D053685:Laser Therapy; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods; D013997:Time Factors
D006415:Hematoporphyrins; D017324:Hematoporphyrin Derivative