HLA and altered sex ratios in juvenile rheumatoid arthritis sibships.
Analysis of sex ratio in 301 siblings of 150 patients with early-onset pauciarticular juvenile rheumatoid arthritis revealed a male-to-female ratio of 1:2.00 in sibships with an HLA-B44+ proband, compared with a ratio of 1:1.05 in other sibships (G2 = 6.07, df = 1, p = 0.014). The siblings had a sex ratio of 1:0.8, when the HLA-B44 antigen was present in either parent but not transmitted to the proband. The capacity to distort the sex ratio was limited therefore to disease-associated HLA-B44 haplotypes.
Van Kerckhove
C
C
Division of Rheumatology, Children's Hospital Medical Center, Cincinnati, OH 45229-2899.
Balakrishnan
K
K
Levinson
J E
JE
Larson
M G
MG
Glass
D N
DN
D000293:Adolescent; D000328:Adult; D001171:Arthritis, Juvenile / Q000235:genetics / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics; D059948:HLA-B44 Antigen; D006239:Haplotypes; D006801:Humans; D007223:Infant; D008297:Male; D012744:Sex Ratio
D006680:HLA Antigens; D015235:HLA-B Antigens; D059948:HLA-B44 Antigen