Genetics of two human monocyte antigens.
HMA-1 and HMA-2 are two serologically defined alloantigens that are present on human monocytes and granulocytes. Previous panel studies suggested that these two antigens comprise a diallelic system. We therefore performed segregation studies on 10 randomly chosen families and on 22 nucleus families belonging to one large pedigree. All individuals were either positive for HMA-1, HMA-2, or both. Segregation of HMA-1 showed autosomal inheritance with complete penetrance. The cytotoxicity negative, absorption positive (CYNAP) phenomenon sometimes occurred for HMA-2, and because absorptions for HMA-2 could not be performed on all cells, linkage studies were only performed for HMA-1. No linkage of HMA-1 with HLA, immunoglobulin allotypes, granulocyte antigens, or any of the erythrocyte blood groups tested was observed.
Jager
M J
MJ
Department of Immunohaematology and Blood Bank, University Hospital, Leiden, The Netherlands.
Claas
F H
FH
Schot
J D
JD
Gratama
J W
JW
de Lange
G
G
van Rood
J J
JJ
D000483:Alleles; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D007519:Isoantigens / Q000235:genetics*; D008297:Male; D009000:Monocytes / Q000276:immunology*; D010375:Pedigree
D007519:Isoantigens