title: [Requirements of nutrients which participate in erythropoiesis].
abstract: Proteins, some minerals and vitamins, play important roles in erythropoiesis and the survival of the red blood cell. This article deals specifically with the physiological requirements and recommended intakes of iron, folate and vitamin B12. A comparison of the physiologic iron requirements according to age and sex, and the amount of iron which is actually absorbed from the diets consumed by the lower socioeconomic strata of the Venezuelan population; indicates that these diets do not satisfy the requirements at all ages. Such disparity is most marked in children below three years of age, in adolescents and in women during their reproductive age. Failure to do so leads to varying degrees of iron deficiency. This low bioavailability of the Venezuelan diet is also observed in other Latin American diets consumed by the same low socioeconomic strata, which explains the high prevalence of iron-deficiency anemia in the vulnerable groups. The low intake of fruits and vegetables by the lower socioeconomic strata of the Latin American population prevents these sectors from consuming an adequate intake of folate, failing to fulfill the daily recommended intake (3.3 - 3.6 micrograms/kg body weight). This situation is aggravated in pregnant and lactating women who require an additional intake of 300 micrograms and 100 micrograms, respectively. Prevalence of folate deficiency in the first stage may be in the order of 30% in some regions. In the second stage of deficiency, characterized by megaloblastic changes in the bone marrow and an erythrocyte folate concentration of less than 50 micrograms/lt, it could be as high as 40% in pregnant women. Nutritional vitamin B12 deficiency does not constitute a health problem in Latin America. Various surveys in the lower socioeconomic strata have reported normal or higher than normal serum B12 concentrations, compared to well-nourished populations.
authors.affiliation: Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.
authors.forename: M
authors.initials: M
authors.lastname: Layrisse
authors.forename: C
authors.initials: C
authors.lastname: Martínez-Torres
authors.forename: H
authors.initials: H
authors.lastname: Méndez-Castellano
authors.forename: P
authors.initials: P
authors.lastname: Taylor
authors.forename: M
authors.initials: M
authors.lastname: Fossi
authors.forename: M
authors.initials: M
authors.lastname: López de Blanco
authors.forename: M
authors.initials: M
authors.lastname: Landaeta-Jiménez
authors.forename: W G
authors.initials: WG
authors.lastname: Jaffé
authors.forename: I
authors.initials: I
authors.lastname: Leets
authors.forename: E
authors.initials: E
authors.lastname: Tropper
mesh_terms: D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000453:epidemiology / Q000209:etiology*; D001682:Biological Availability; D002648:Child; D002675:Child, Preschool; D003300:Copper / Q000172:deficiency; D003430:Cross-Sectional Studies; D004032:Diet; D004920:Erythropoiesis; D005260:Female; D005494:Folic Acid Deficiency / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007501:Iron / Q000493:pharmacokinetics; D000090463:Iron Deficiencies; D008297:Male; D009748:Nutrition Disorders / Q000150:complications; D009751:Nutritional Requirements; D011247:Pregnancy; D014687:Venezuela / Q000453:epidemiology; D014802:Vitamin A Deficiency / Q000150:complications; D014806:Vitamin B 12 Deficiency / Q000150:complications / Q000453:epidemiology
chemical_list: D003300:Copper; D007501:Iron
vernacular_title: Requerimientos de nutrientes que participan en la eritropoyesis.