Potentiation of motoneurone excitability by combined administration of 5-HT agonist and TRH analogue.
Motoneurone field potentials have been recorded from the lumbar region of the spinal cord, to antidromic stimulation of a ventral root, in rats anaesthetised with urethane. Injection of the thyrotropin releasing hormone (TRH) analogue RX77368 (1mg/kg) plus the 5-hydroxytryptamine (5-HT) receptor agonist 5-methoxy-N, N-dimethyl-tryptamine (5MeODMT 0.4mg/kg) resulted in a potentiation of the increase in amplitude and duration of response, compared to when the drugs were given singly. These results are discussed in the context of possible interactions between 5-HT and TRH systems.
Clarke
K A
KA
Parker
A J
AJ
Stirk
G C
GC
D000818:Animals; D000870:Anterior Horn Cells / Q000187:drug effects*; D004357:Drug Synergism; D005260:Female; D010134:Fenclonine / Q000008:administration & dosage; D007650:Ketanserin; D008732:Methoxydimethyltryptamines / Q000008:administration & dosage* / Q000494:pharmacology; D008784:Methysergide / Q000008:administration & dosage; D009046:Motor Neurons / Q000187:drug effects*; D010880:Piperidines / Q000008:administration & dosage; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D012701:Serotonin / Q000031:analogs & derivatives*; D013268:Stimulation, Chemical; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D008732:Methoxydimethyltryptamines; D010880:Piperidines; D012701:Serotonin; D013973:Thyrotropin-Releasing Hormone; C027979:L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide; D007650:Ketanserin; D010134:Fenclonine; D011761:Pyrrolidonecarboxylic Acid; D008784:Methysergide