The effects of repeated administration of fluprazine on target biting and intruder-evoked attacks.
The effects of repeated administration of fluprazine, an "aggression"-reducing drug, were evaluated in mice using the target biting and resident-intruder paradigms. Under baseline conditions there was a high target biting rate immediately after the delivery of a 2.0 mA tail shock, an intermediate target biting rate during a 2-min intershock interval, and a low target biting rate during a 15-s tone stimulus which signaled the shock. During the 10-min resident intruder test sessions, resident males attacked bulbectomized intruders an average of six times with an average latency to the first attack of 258 s. In the prechronic dose-response curve determination, fluprazine caused a dose-dependent decrease in postshock and intershock interval target biting behavior, increased the latency to the first attack, and decreased the number of attacks in the intruder-evoked aggression paradigm. During the chronic administration of the ED50 dose of fluprazine, intershock interval target biting gradually increased to a level equal to those subjects receiving chronic saline. Moreover, a shift (to the right) in the during-chronic fluprazine dose-response curve for postshock and intershock interval target biting, was observed. Likewise, during the chronic administration of the ED50 dose of fluprazine, resident number of attacks gradually increased to a level equal to those subjects receiving chronic saline. However, no shift in the during-chronic dose-response curve was observed in subjects tested in this paradigm.
Carelli
R M
RM
Department of Psychology, Rutgers, State University, New Brunswick, NJ 08903.
Wagner
G C
GC
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D008297:Male; D051379:Mice; D010879:Piperazines / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D013997:Time Factors
D010879:Piperazines; D011619:Psychotropic Drugs; C035521:fluprazine