Alterations in diastolic ventricular interdependence due to myocardial infarction.
The pressure and volume in one ventricle can directly influence the pressure and volume in the other ventricle. Since this mechanical coupling depends on the anatomical structure of the heart, we postulated that disease states which alter regional ventricular compliance will alter the mechanical coupling between the ventricles. We examined this hypothesis in six dogs, each with a prior myocardial infarction involving solely the left ventricular free wall. The animals were sacrificed, the hearts removed and placed in cool cardioplegic solution. Balloons were inserted into each ventricle and the left and right pressure (dPl,dPr) and volume (dVl,dVr) changes (or transfer) caused by change to the pressure and volume of the other ventricle were recorded. In five additional experiments, acute changes in compliance were induced by injecting glutaraldehyde into the left ventricular free wall. The results of these experiments were compared to four control experiments. As compared to the control experiments, the transfer functions dPl/dPr, dPl/dVr, dPr/dVl, and dVr/dVl increased significantly (p less than 0.05) in the infarct and glutaraldehyde groups, while the transfer functions dVl/dPr, dVl/dVr, dPr/dPl and dVr/dPl were unaltered in the infarct and glutaraldehyde groups. The results of these studies show significant selective alteration in the mechanical coupling between the ventricles following left ventricular free wall infarction.
Santamore
W P
WP
Section on Cardiology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Papa
L
L
D000818:Animals; D001696:Biomechanical Phenomena; D001794:Blood Pressure; D003187:Compliance; D003971:Diastole; D004285:Dogs; D005976:Glutaral / Q000494:pharmacology; D006321:Heart / Q000503:physiopathology*; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D009203:Myocardial Infarction / Q000503:physiopathology*
D005976:Glutaral