Facilitation of cancer-associated anorexia by cholecystokinin.
Cholecystokinin octapeptide (CCK-8, 5 micrograms/kg) was injected i.p. into male Sprague-Dawley rats bearing the Walker 256-carcinosarcoma, or into non-tumour bearing controls, on a 20-h food deprivation schedule. Food and water intake and body weight maintenance were monitored for 15 days after tumour implantation and compared to that of tumour-bearing animals not injected with CCK-8. Food intake was significantly reduced for the duration of the two 4-day periods of CCK-8 injection, indicating that behavioural tolerance to this peptide did not occur. The severity of anorexia and body weight loss in tumour-bearing animals was significantly greater than that observed in non-tumour bearing controls, for the first 13 days of observation. These results indicate that endogenous peptides, such as CCK, may function in tumour-bearing animals to enhance the anorexia and wasting which typifies the anorexia cachexia syndrome.
Willis
G L
GL
Monash University, Department of Psychological Medicine, Prince Henry's Hospital, Melbourne, Vic., Australia.
Sleeman
M
M
Smith
G C
GC
D000818:Animals; D000855:Anorexia / Q000209:etiology*; D001835:Body Weight / Q000187:drug effects; D002100:Cachexia / Q000209:etiology; D002279:Carcinoma 256, Walker / Q000150:complications* / Q000503:physiopathology; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D001068:Feeding and Eating Disorders / Q000209:etiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000187:drug effects / Q000502:physiology; D012844:Sincalide / Q000494:pharmacology*
D012844:Sincalide