Reactive hyperemia monitored on rat muscle using perfluorocarbons and 19F NMR.
Perfluorinated blood substitutes can be detected by 19F NMR in vivo in small concentrations. Reactive hyperemia was induced in rat leg by the transient application of a tourniquet, causing a 50% increase in 19F NMR signal. These results show that this method can be used to monitor the kinetics of tissue perfusion.
Authier
B
B
DRF/SPh/RMBM, Centre d'Etudes Nucléaires de Grenoble, France.
D000818:Animals; D005466:Fluorocarbons; D006614:Hindlimb; D006940:Hyperemia / Q000209:etiology / Q000503:physiopathology*; D007511:Ischemia / Q000150:complications; D009682:Magnetic Resonance Spectroscopy; D009132:Muscles / Q000098:blood supply*; D051381:Rats; D012039:Regional Blood Flow
D005466:Fluorocarbons; C008807:perfluorotributylamine