title: Fungal pneumonias masquerading as thromboses during induction therapy of acute lymphoblastic leukemia.
abstract: Fatal fungal pneumonias developed in two children with ALL during remission induction. Pulmonary and central nervous system signs suggested the L-asparaginase-induced multiple-thromboses syndrome in both children. Fungal infection should be considered-whenever pneumonia develops in a neutropenic child already receiving broad-spectrum antibiotics or when multiple thromboses occur.
authors.affiliation: Department of Pediatrics, University of Minnesota, School of Medicine, Minneapolis.
authors.forename: A D
authors.initials: AD
authors.lastname: Pearson
authors.forename: M E
authors.initials: ME
authors.lastname: Nesbit
authors.forename: P J
authors.initials: PJ
authors.lastname: Darbyshire
authors.forename: M G
authors.initials: MG
authors.lastname: Mott
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage / Q000009:adverse effects; D001228:Aspergillosis / Q000175:diagnosis*; D002675:Child, Preschool; D003630:Daunorubicin / Q000008:administration & dosage; D003951:Diagnostic Errors; D004678:Encephalomalacia / Q000209:etiology; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced / Q000175:diagnosis*; D008172:Lung Diseases, Fungal / Q000175:diagnosis*; D008297:Male; D009091:Mucormycosis / Q000175:diagnosis*; D011014:Pneumonia / Q000175:diagnosis*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D011241:Prednisone / Q000008:administration & dosage; D013927:Thrombosis / Q000139:chemically induced / Q000175:diagnosis*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D001215:Asparaginase; D011241:Prednisone; D003630:Daunorubicin