Estrogen-like effect of 5-androstene-3 beta,17 beta-diol on the induction of fetal thymidine kinase in the rat uterus.
The action of 5-androstene-3 beta,17 beta-diol (Adiol) on Thymidine Kinase (TK) was studied in the rat uterus. It appeared that Adiol, like 17 beta-estradiol (E2), could induce the synthesis of the fetal isoenzyme of TK. Its effects compared with those of E2, were delayed by 6 h and higher doses were required to reach the same levels of induction. The action of Adiol on TK was exclusively observed in tissues where E2 receptors were present. Moreover, Adiol could stimulate the activity of uterine DNA-polymerase alpha. These observations are additional evidence of the estrogen-like behaviour of Adiol. They suggest that it could participate in proliferative processes of tissues which are dependent on estrogens.
Leroy
B
B
Centre Régional de Recherche en Endocrinologie, Faculté de Médecine-Pharmacie, Rennes, France.
Maquaire
E
E
Samperez
S
S
Jouan
P
P
D015114:Androstenediol / Q000378:metabolism / Q000494:pharmacology*; D000734:Androstenediols / Q000494:pharmacology*; D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D003600:Cytosol / Q000201:enzymology; D004257:DNA Polymerase II / Q000378:metabolism; D003609:Dactinomycin / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007527:Isoenzymes / Q000096:biosynthesis; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011959:Receptors, Estradiol / Q000378:metabolism; D013937:Thymidine Kinase / Q000096:biosynthesis*; D014599:Uterus / Q000033:anatomy & histology / Q000201:enzymology*
D000734:Androstenediols; D007527:Isoenzymes; D011959:Receptors, Estradiol; D003609:Dactinomycin; D004958:Estradiol; D015114:Androstenediol; D003513:Cycloheximide; D013937:Thymidine Kinase; D004257:DNA Polymerase II