A computer model to study norepinephrine-induced oscillations of contraction in tail arteries of spontaneously hypertensive stroke-prone rats.
The purpose of this study is to develop a computer model of oscillatory contractions in isolated arteries from the tails of spontaneously hypertensive, stroke-prone rats (SHRSP). The computer simulation incorporates biologic data from experiments and mathematic expressions derived from an electric circuit model of the biologic system. The model characterizes the cellular mechanisms which have been proposed to be responsible for the oscillatory activity. Results indicate the ability of the model to provide results which closely match experimentally obtained data.
Avinash
G
G
Department of Electrical Engineering, Southern Illinois University, Carbondale 62901.
Myers
J H
JH
Rawlings
C A
CA
D000818:Animals; D001158:Arteries / Q000502:physiology; D003198:Computer Simulation; D008838:Microcomputers; D008955:Models, Cardiovascular; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D012984:Software; D013623:Tail / Q000098:blood supply
D009638:Norepinephrine