title: An illustration of dangers of ignoring survival differences in carcinogenic data.
abstract: This paper illustrates the effects of survival differences on the routine analysis of 2-year animal carcinogenesis experiments using quantal response. Not adjusting for decreased survival in the higher dosed groups results in a decrease in the actual significance level for the quantal response trend test, and a corresponding decrease in sensitivity for detecting a true treatment effect. Similar results hold for estimation of carcinogenic risk. Tables of the range of survival differences found in recent National Toxicology Program carcinogenesis studies are presented.
authors.affiliation: Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, NC 27709.
authors.forename: A J
authors.initials: AJ
authors.lastname: Bailer
authors.forename: C J
authors.initials: CJ
authors.lastname: Portier
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000401:mortality*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D002273:Carcinogens