title: Thyroid function in children after cytostatic treatment for acute leukemia.
abstract: Sixty-one children were examined for thyroid dysfunction as an adverse late effect after cessation of antileukemic treatment. The aim of the study was to contribute to clarifying which types of therapy can cause this endocrine disorder. Our treatment protocols do not include cranial irradiation as CNS prophylaxis, but we give relatively intensive intrathecal methotrexate treatment. The results indicate that this cytostatic regimen alone does not cause thyroid dysfunction as an adverse late effect.
authors.affiliation: Department of Pediatrics, University Hospital, Trondheim, Norway.
authors.forename: R
authors.initials: R
authors.lastname: Nygaard
authors.forename: K S
authors.initials: KS
authors.lastname: Bjerve
authors.forename: S
authors.initials: S
authors.lastname: Kolmannskog
authors.forename: P J
authors.initials: PJ
authors.lastname: Moe
authors.forename: F
authors.initials: F
authors.lastname: Wesenberg
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D013959:Thyroid Diseases / Q000139:chemically induced*
chemical_list: D008727:Methotrexate