title: Effect of ofloxacin on the pharmacokinetics of a single intravenous theophylline dose.
abstract: The effect of ofloxacin taken for 8 days (200 mg twice daily) on the pharmacokinetics of a single intravenous dose of theophylline (4.3 mg/kg over 15 min) was studied in a crossover procedure among seven healthy male volunteers. Theophylline concentrations were measured serially for 10 h by the immunofluorescence polarization technique. No significant effect of ofloxacin was found on theophylline clearance, half-life, or volume of distribution. It is therefore concluded that ofloxacin and theophylline can be safely administered together.
authors.affiliation: Faculty of Pharmacy, University of Jordan, Amman.
authors.forename: W A
authors.initials: WA
authors.lastname: Al-Turk
authors.forename: O M
authors.initials: OM
authors.lastname: Shaheen
authors.forename: S
authors.initials: S
authors.lastname: Othman
authors.forename: R M
authors.initials: RM
authors.lastname: Khalaf
authors.forename: A S
authors.initials: AS
authors.lastname: Awidi
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology*; D013806:Theophylline / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin; D013806:Theophylline