title: Suppression of active cross-bridge motions of isolated thick myofilaments in suspension by phenylmethylsulfonyl fluoride.
abstract: Studies of photoelectron count autocorrelation function of light scattered from suspensions of thick filaments of Limulus telson muscle and scallop striated adductor muscle reveal that Ca2+ can activate cross-bridge motions of these isolated filaments. By treating suspensions of activated filaments with phenylmethylsulfonyl fluoride (PMSF), we can suppress active cross-bridge motions but not affect the Ca2+-dependent ATPase activity.
authors.forename: S F
authors.initials: SF
authors.lastname: Fan
authors.forename: M M
authors.initials: MM
authors.lastname: Dewey
authors.forename: D
authors.initials: D
authors.lastname: Colflesh
authors.forename: B
authors.initials: B
authors.lastname: Gaylinn
authors.forename: R
authors.initials: R
authors.lastname: Greguski
authors.forename: B
authors.initials: B
authors.lastname: Chu
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D003599:Cytoskeleton / Q000187:drug effects*; D006737:Horseshoe Crabs; D008974:Mollusca; D009038:Motion; D009119:Muscle Contraction / Q000187:drug effects*; D009218:Myosins / Q000037:antagonists & inhibitors*; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology*; D013450:Sulfones / Q000494:pharmacology*
chemical_list: D013450:Sulfones; D010664:Phenylmethylsulfonyl Fluoride; D000251:Adenosine Triphosphatases; D009218:Myosins