Cytogenetic investigation of chemically-induced aneuploidy in mouse spermatocytes.
This paper discusses a test system in which mouse spermatocytes are analyzed for aneuploidy induction after mice are treated with various agents. Included in this report are methods and procedures of the assay, criteria for determination of aneuploidy induction, considerations for dose-response and stage-specific actions of agents that cause aneuploidy, and finally, advantages and disadvantages of this test system.
Liang
J C
JC
Department of Laboratory Medicine, University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston 77030.
Pacchierotti
F
F
D000782:Aneuploidy; D000818:Animals; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D008297:Male; D008677:Metaphase; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D013090:Spermatocytes / Q000648:ultrastructure; D014178:Translocation, Genetic
D009153:Mutagens