title: Reaction of fibroblasts to various dental casting alloys.
abstract: The cytotoxicity of a series of dental casting alloys in the as-cast and polished condition was determined with cell culture techniques involving phase contrast microscopy to examine cell morphology and the succinic dehydrogenase histochemical reaction to measure any ring of inhibition of Balb/c 3T3 cellular respiration around alloys. Crown and bridge casting alloys and a nickel- and a cobalt-base alloy were biocompatible in the polished condition, but less so in the as-cast condition. The only two exceptions were casting alloys containing 50-60 wt% Cu. Porcelain-fused-to-metal alloys were biocompatible in either the as-cast or polished condition. This direct contact method appeared satisfactory for evaluating biocompatibility of dental casting alloys, especially since these materials are in contact with gingival tissues.
authors.affiliation: School of Dentistry, University of Michigan, Ann Arbor 48109-1078.
authors.forename: R G
authors.initials: RG
authors.lastname: Craig
authors.forename: C T
authors.initials: CT
authors.lastname: Hanks
mesh_terms: D000497:Alloys; D000818:Animals; D002478:Cells, Cultured; D002858:Chromium Alloys / Q000633:toxicity; D003722:Dental Alloys / Q000633:toxicity*; D003734:Dental Casting Investment / Q000633:toxicity*; D005347:Fibroblasts / Q000187:drug effects; D006047:Gold Alloys / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008858:Microscopy, Phase-Contrast; D014025:Titanium / Q000633:toxicity
chemical_list: D000497:Alloys; D002858:Chromium Alloys; D003722:Dental Alloys; D003734:Dental Casting Investment; D006047:Gold Alloys; C031462:titanium alloy (TiAl6V4); D014025:Titanium