title: Age-associated changes in stratum corneum lipids and their relation to dryness.
abstract: Stratum corneum lipids (SCL) were collected on the right and left legs of 50 subjects of varying ages and skin dryness. The level of dryness and composition of the lipid was the same on both sides. While skin dryness continuously increased with age, the composition of SCL showed a constant profile from the 50s. Aging was mostly associated with a decrease in sterol esters and triglycerides. On the legs, the SCL do not seem to primarily govern the increased desquamative process which features xerosis.
authors.affiliation: Laboratoires de Recherche de L'Oréal, Département de Biophysique, Aulnay-Sous-Bois, France.
authors.forename: D
authors.initials: D
authors.lastname: Saint Léger
authors.forename: A M
authors.initials: AM
authors.lastname: François
authors.forename: J L
authors.initials: JL
authors.lastname: Lévêque
authors.forename: T J
authors.initials: TJ
authors.lastname: Stoudemayer
authors.forename: G L
authors.initials: GL
authors.lastname: Grove
authors.forename: A M
authors.initials: AM
authors.lastname: Kligman
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D004817:Epidermis / Q000032:analysis* / Q000378:metabolism; D005260:Female; D006801:Humans; D007866:Leg; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000378:metabolism / Q000473:pathology; D012871:Skin Diseases / Q000378:metabolism / Q000473:pathology*
chemical_list: D008055:Lipids