[Effect of intrabladder instillation of various anticancer agents on carcinogenesis in rat bladder].
After administration of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) to 6-week-old, female F344 rats, various anticancer agents and immunotherapeutic agents were injected into the bladder and their effects were investigated. Injection of adriamycin and mitomycin C (MMC) into the bladder a total of 12 times, 4 weeks after administration of BBN markedly promoted carcinogenesis of the bladder. Injection of bleomycin, cis-dichlorodiamine platinum (CDDP) and picibanil into the bladder a total of 12 times, 4 weeks after administration of BBN did not promote carcinogenesis and CDDP exhibited a tendency to inhibit carcinogenesis. Injection of MMC, CA (cytarabine) and MMC + CA into the bladder a total of 12 times, 4 weeks after administration of BBN indicated that CA has the potential to inhibit the bladder carcinogenesis-promoting effect of MMC. Injection of CDDP and MMC into the bladder a total of 12 times, 20 weeks after administration of BBN inhibited proliferation of bladder carcinoma. Additionally, administration each of CDDP and MMC alone exhibited a carcinogenic effect on the bladder. The above-described results show that considerable care should be taken and that long-term observation of course is required with the use of anticancer agents such as ADM and MMC.
Okamura
T
T
Department of Urology, Medical School, Nagoya City University.
D000283:Administration, Intravesical; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002085:Butylhydroxybutylnitrosamine; D004317:Doxorubicin / Q000009:adverse effects; D005260:Female; D006965:Hyperplasia; D016685:Mitomycin; D008937:Mitomycins / Q000009:adverse effects; D051381:Rats; D011916:Rats, Inbred F344; D001743:Urinary Bladder / Q000187:drug effects / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
D000970:Antineoplastic Agents; D008937:Mitomycins; D002085:Butylhydroxybutylnitrosamine; D016685:Mitomycin; D004317:Doxorubicin