title: [Clinical experience with ofloxacin in the treatment of chronic respiratory tract disease aggravated by acute infection].
abstract: We studied the clinical usefulness of ofloxacin (OFLX) in 13 patients with chronic respiratory tract diseases aggravated by acute infections with identified causative bacteria. 1. Overall clinical efficacies were: highly effective 5, effective 6, slightly effective 2, and ineffective none, showing an efficacy rate of 84.6%. 2. In 6 patients with fever of over 37 degrees C, time lengths in days for symptoms to have been alleviated due to OFLX treatment were; 1 day: 4 cases, 3 days: 1 case and 5 days: 1 case (2.0 days on average). 3. As to bacterial transitions, in 9 of 10 patients Haemophilus influenzae was eliminated and in 1 patient it was substituted by Pseudomonas aeruginosa. In 3 patients Branhamella catarrhalis was eliminated and in 1 patient, the number of P. aeruginosa was reduced. OFLX is expected to have a potent bacteriological effect on H. influenzae and B. catarrhalis. 4. As to side effects, 1 of the 13 patients (7.7%) complained of discomfort in the epigastrium. This discomfort disappeared when a gastric mucosa protective agent was administered. There was no abnormality in laboratory test values. Judging from the above results, we consider OFLX a useful drug for the treatment of patients with chronic respiratory tract diseases aggravated by acute infections.
authors.affiliation: Department of Chest Medicine, School of Medicine, Chiba University.
authors.forename: N
authors.initials: N
authors.lastname: Muraki
authors.forename: R M
authors.initials: RM
authors.lastname: Chen
authors.forename: I
authors.initials: I
authors.lastname: Kakusaka
authors.forename: T
authors.initials: T
authors.lastname: Kuriyama
authors.forename: H
authors.initials: H
authors.lastname: Kanno
authors.forename: N
authors.initials: N
authors.lastname: Kikuchi
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: F
authors.initials: F
authors.lastname: Yamagishi
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006193:Haemophilus influenzae / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D015242:Ofloxacin