Modulation of T-cell subsets in asthmatic children by THF, a thymic hormone.
Induction of theophylline-sensitive T-suppressor cells with THF, a thymic hormone, resulted in elevation of the low levels of these lymphocytes in non-treated asthmatic children. Evaluation, however, by monoclonal OKT8 antibodies did not show changes in the levels of the OKT8+ cells after THF incubation. In the treated asthmatic children, normal levels of theophylline-sensitive T-suppressor cells as well as OKT8+ cells were found. These normal levels were not changed with THF after in vitro incubation.
Shohat
B
B
Volovitz
B
B
Varsano
I
I
Trainin
N
N
D000293:Adolescent; D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006087:Graft vs Host Reaction / Q000187:drug effects; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D051381:Rats; D013601:T-Lymphocytes / Q000145:classification / Q000187:drug effects*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects; D013806:Theophylline / Q000494:pharmacology; D013947:Thymosin / Q000494:pharmacology*
D013947:Thymosin; D013806:Theophylline