title: Recombination between HLA-A and C and between HLA-B and complement locus C4 in the same individual.
abstract: In a French family with 2 parents and 5 children a crossing over was found in the HLA region on both of the parental haplotypes of one of the children. The following markers were studied: HLA-A, B, C,DR, DQ(MB), DP(SB), complement allotypes C4 and Bf and glyoxalase I polymorphism. In the third child, the paternal haplotype had a recombination between HLA-A and HLA-C and the maternal haplotype a recombination between HLA-B and complement locus C4. Mixed lymphocyte cultures confirmed the serological findings and non-HLA markers (blood groups and immunoglobulin allotypes) showed no evidence of extrapaternity. The family also demonstrates a probable duplication of the C4B1 gene in one of the paternal haplotypes.
authors.forename: M
authors.initials: M
authors.lastname: Thomsen
authors.forename: A
authors.initials: A
authors.lastname: Cambon-Thomsen
authors.forename: M
authors.initials: M
authors.lastname: Abbal
authors.forename: M
authors.initials: M
authors.lastname: Calot
authors.forename: J
authors.initials: J
authors.lastname: Arnaud
authors.forename: E
authors.initials: E
authors.lastname: Ohayon
mesh_terms: D003181:Complement C4 / Q000235:genetics*; D003434:Crossing Over, Genetic; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic
chemical_list: D003181:Complement C4; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens