title: Cocaine-associated myocardial infarction. A word of caution about thrombolytic therapy.
abstract: The recent approval of tissue plasminogen activator (tPA) by the Food and Drug Administration has opened a new era in the management of acute coronary occlusions. Absolute contraindications are well established. A case of intracranial bleeding as a complication of thrombolytic therapy in an intravenous substance abuser is presented. This may represent a relative contraindication to thrombolytic therapy.
authors.affiliation: Department of Internal Medicine, Ben Taub General Hospital, Houston.
authors.forename: H S
authors.initials: HS
authors.lastname: Bush
mesh_terms: D000328:Adult; D002543:Cerebral Hemorrhage / Q000139:chemically induced; D003042:Cocaine; D005343:Fibrinolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000209:etiology; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D005343:Fibrinolytic Agents; D003042:Cocaine