Potentiation of beta-endorphin effects by proglumide in rats.
The effects of proglumide, a cholecystokinin (CCK) receptor antagonist, on the analgesia and catalepsy induced by beta-endorphin were investigated in rats. Proglumide itself produced a slight analgesia but no catalepsy. Combined intracerebroventricular administration of beta-endorphin and proglumide produced marked potentiation of the analgesic and cataleptic effects of beta-endorphin. The results suggest that endogenous CCK may have an antagonistic effect on the actions of beta-endorphin in the brain.
Katsuura
G
G
Itoh
S
S
D000698:Analgesia; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004723:Endorphins / Q000494:pharmacology*; D005973:Glutamine / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D011377:Proglumide / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012844:Sincalide / Q000037:antagonists & inhibitors; D001615:beta-Endorphin
D004723:Endorphins; D005973:Glutamine; D001615:beta-Endorphin; D011377:Proglumide; D012844:Sincalide