title: The Daedalus effect: changes in ethical questions relating to hepatitis B virus.
abstract: The Daedalus myth is a metaphor for aspects of the scientific process. When a problem is solved it often raises others, and when these in turn are solved they generate additional questions. Although perfect solutions may not be possible, major improvements can be made in many cases. Research on the hepatitis B virus is an example. The ability to detect carriers of hepatitis B virus contributed to the control of post-transfusion hepatitis but raised social and ethical problems inherent to the identification of carriers in the community. Partial solutions to this problem resulted from the ability to distinguish infectious from noninfectious carriers by the use of the hepatitis B antigen (HBeAg) test and the development of an effective vaccine against hepatitis B virus. These solutions will undoubtedly lead to other problems and their solutions, which will in turn lead to other ethical and medical questions.
authors.forename: B S
authors.initials: BS
authors.lastname: Blumberg
authors.forename: R C
authors.initials: RC
authors.lastname: Fox
mesh_terms: D001675:Bioethics; D001782:Blood Donors; D002353:Carrier State / Q000175:diagnosis*; D004641:Emigration and Immigration; D006509:Hepatitis B / Q000175:diagnosis* / Q000517:prevention & control / Q000635:transmission; D017325:Hepatitis B Vaccines; D006801:Humans; D008403:Mass Screening; D009229:Mythology; D010559:Personnel Management; D010564:Personnel, Hospital; D011287:Prejudice; D011340:Problem Solving; D012106:Research; D012962:Sociology, Medical; D014611:Vaccination; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage
chemical_list: D017325:Hepatitis B Vaccines; D014761:Viral Hepatitis Vaccines