title: Substances released during tetanic stimulation of rabbit neocortex induce neurite growth in PC-12 cells and long-term potentiation in guinea pig hippocampus.
abstract: Samples collected from rabbit neocortical surface during a tetanic stimulation of the neocortex induced neurite growth in PC-12 cells in culture and synaptic long-term potentiation (LTP) in guinea pig hippocampal slices. If these samples were preheated and cooled, or if they were collected in the absence of a tetanic stimulation of the rabbit neocrotex, they did not induce neurite growth in PC-12 cells or LTP in the guinea pig hippocampus. These results suggest that neurite-inducing factors are released during tetanic stimulations and that these substances are involved in LTP.
authors.affiliation: Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
authors.forename: B R
authors.initials: BR
authors.lastname: Sastry
authors.forename: S S
authors.initials: SS
authors.lastname: Chirwa
authors.forename: P B
authors.initials: PB
authors.lastname: May
authors.forename: H
authors.initials: H
authors.lastname: Maretić
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000378:metabolism* / Q000502:physiology; D004558:Electric Stimulation; D005071:Evoked Potentials; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D009414:Nerve Growth Factors; D010455:Peptides / Q000378:metabolism* / Q000494:pharmacology; D010673:Pheochromocytoma; D011817:Rabbits; D051381:Rats; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000502:physiology*
chemical_list: D009414:Nerve Growth Factors; D010455:Peptides; C047805:neurite-inducing factor