Blood pressure in resting, anesthetized and noise-exposed guinea pigs.
This study investigated blood pressure in guinea pigs while they were 1) alert and free moving, 2) anesthetized with different anesthetics, and 3) exposed to continuous, 115 dB SPL white noise under anesthesia. The animals were prepared with a carotid artery catheter and permitted to recover for 48 h before blood pressure levels were measured. Mean arterial blood pressure in the resting, unrestrained guinea pig was 64 mmHg (+/- 1.38 S.E.). Ketamine Hydrochloride (Ketamine) significantly decreased, and Fentanyl-Citrate significantly increased, blood pressure. Fentanyl-Droperidol produced no substantial blood pressure change. Guinea pigs anesthetized with Fentanyl-Citrate and Fentanyl-Droperidol demonstrated significant blood pressure increases when exposed to noise, with the Fentanyl-Citrate group showing a greater response. Animals anesthetized with Ketamine Hydrochloride exhibited no significant blood pressure changes when exposed to the noise.
Flynn
A J
AJ
Department of Psychology, Washington State University, Pullman.
Dengerink
H A
HA
Wright
J W
JW
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D004329:Droperidol / Q000494:pharmacology; D004338:Drug Combinations / Q000494:pharmacology; D005283:Fentanyl / Q000494:pharmacology; D006168:Guinea Pigs; D007649:Ketamine / Q000494:pharmacology; D009622:Noise
D000777:Anesthetics; D004338:Drug Combinations; D007649:Ketamine; C001451:Innovar; D004329:Droperidol; D003975:Diazepam; D005283:Fentanyl