Testing the hypothesis that crypt cell hyperplasia inhibits lactase expression by mouse jejunal enterocytes.
Lactase activity and crypt cell proliferation both increased significantly in mouse jejunal villi in the presence of the intestinal parasite Nematospiroides dubius. Comparisons are made between this result and others showing lactase activity to decline whenever crypt cell proliferation is increased.
Smith
M W
MW
Department of Cell Biology, AFRC Institute of Animal Physiology, Babraham, Cambridge.
Lloyd
S
S
James
P S
PS
D000818:Animals; D005696:Galactosidases / Q000037:antagonists & inhibitors*; D006801:Humans; D006965:Hyperplasia; D007583:Jejunum / Q000201:enzymology / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009349:Nematode Infections / Q000201:enzymology / Q000473:pathology*; D009351:Nematospiroides dubius; D051381:Rats; D012016:Reference Values; D001616:beta-Galactosidase / Q000037:antagonists & inhibitors*
D005696:Galactosidases; D001616:beta-Galactosidase