title: A laser Raman spectroscopic study of the interaction of the methylmercury cation with AMP, ADP and ATP.
abstract: The interaction of the CH3Hg+ cation with adenosine 5'-monophosphate, adenosine 5'-diphosphate, and adenosine 5'-triphosphate has been studied in aqueous solution at neutral pH by laser Raman spectroscopy. Metal binding is shown to occur preferentially at the N-1 ring position of adenine, with some indication of coordination to the N-7 site and substitution of a proton on the exocyclic NH2 group of the nucleic base. Binding of the cation to phosphate groups also occurs extensively, with both the -PO2-3 and -PO-2 groups. The equilibrium constants for the binding to the phosphate groups and for N-1 coordination are approx. 70 and 600 M-1, respectively.
authors.affiliation: Département de Chimie et CRAM, Université Laval, Québec, Canada.
authors.forename: H A
authors.initials: HA
authors.lastname: Tajmir-Riahi
authors.forename: M
authors.initials: M
authors.lastname: Langlais
authors.forename: R
authors.initials: R
authors.lastname: Savoie
mesh_terms: D000244:Adenosine Diphosphate; D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate; D006863:Hydrogen-Ion Concentration; D007834:Lasers; D008767:Methylmercury Compounds; D008954:Models, Biological; D012996:Solutions; D013059:Spectrum Analysis, Raman / Q000379:methods
chemical_list: D008767:Methylmercury Compounds; D012996:Solutions; C030957:methylmercury II; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate