Production of parathyroid hormone-related protein in adult T-cell leukemia cells.
Human parathyroid hormone-related protein (PTHrP) mRNA was detected in peripheral leukemic cells obtained from adult T-cell leukemia (ATL) patients as well as in cultured human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines. In contrast, PTHrP mRNA was not detected in other types of leukemic cells. Using radioimmunoassay, immunoreactive PTHrP was also detected in the spent media of HTLV-I-infected T-cell lines. These results suggest that PTHrP plays an important role in developing the hypercalcemia frequently observed in ATL patients.
Honda
S
S
Growth Factor Division, National Cancer Center Research Institute, Tokyo.
Yamaguchi
K
K
Miyake
Y
Y
Hayashi
N
N
Adachi
N
N
Kinoshita
K
K
Ikehara
O
O
Kimura
S
S
Kinoshita
T
T
Shimotohno
K
K
D015490:HTLV-I Infections / Q000378:metabolism; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D015458:Leukemia, T-Cell / Q000150:complications / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D044162:Parathyroid Hormone-Related Protein; D012333:RNA, Messenger / Q000032:analysis; D014407:Tumor Cells, Cultured
D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D012333:RNA, Messenger