Long-term antibiotic therapy for acne vulgaris: effects on the bowel flora of patients and their relatives.
We have studied the effects of long-term tetracycline and erythromycin administration on the fecal flora of patients and their relatives. Tetracycline administration selects for multiply antibiotic-resistant organisms in both patients and relatives. Erythromycin exerts no such selection pressure. The mechanisms by which this may occur are discussed.
Adams
S J
SJ
Cunliffe
W J
WJ
Cooke
E M
EM
D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000627:therapeutic use*; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008297:Male; D013752:Tetracycline / Q000627:therapeutic use*; D013997:Time Factors
D004917:Erythromycin; D013752:Tetracycline