Alterations of cell-surface carbohydrates during differentiation and development.
Expression of many cell-surface carbohydrates is controlled temporally and spatially by developmental programs. This subject is reviewed from 5 viewpoints: structural changes revealed by chemical analysis, cell-surface markers useful for cell identification and separation, core proteins carrying the developmentally regulated carbohydrate chain, glycosyltransferases responsible for the change and the biological meaning of the phenomenon. The differentiation systems covered are mainly early mammalian embryogenesis and the differentiation of blood and nerve cells.
Muramatsu
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Department of Biochemistry, Faculty of Medicine, Kagoshima University, Japan.
D000818:Animals; D015415:Biomarkers; D001773:Blood Cells / Q000166:cytology / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002240:Carbohydrate Sequence; D002454:Cell Differentiation; D002462:Cell Membrane / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000166:cytology / Q000378:metabolism; D004625:Embryo, Nonmammalian; D006023:Glycoproteins / Q000378:metabolism; D008969:Molecular Sequence Data; D009474:Neurons / Q000166:cytology / Q000378:metabolism
D015415:Biomarkers; D006023:Glycoproteins