title: In-vitro activity of fleroxacin.
abstract: Fleroxacin is a new synthetic fluorinated quinolone antimicrobial agent. The in-vitro activity of fleroxacin and five comparative quinolones against 541 clinical isolates was studied. Minimum inhibitory concentrations (MIC90) of fleroxacin were less than or equal to 2.0 mg/l for Enterobacteriaceae, less than or equal to 8.0 mg/l for Pseudomonas aeruginosa and 1.0 mg/l for Acinetobacter calcoaceficis and 8 mg/l for streptococci. The activity of fleroxacin was comparable with that of ofloxacin, pefloxacin and norfloxacin, but less than that of ciprofloxacin. All quinolones showed little difference between MIC and minimum bactericidal concentrations (MBCs).
authors.affiliation: Department of Chemotherapy, University of Vienna.
authors.forename: A
authors.initials: A
authors.lastname: Georgopoulos
authors.forename: S
authors.initials: S
authors.lastname: Breyer
authors.forename: M
authors.initials: M
authors.lastname: Georgopoulos
authors.forename: H
authors.initials: H
authors.lastname: Mailer
authors.forename: W
authors.initials: W
authors.lastname: Graninger
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects*; D016576:Fleroxacin; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D016576:Fleroxacin