Acquired immunodeficiency syndrome transmitted by transplanted kidney: clinical course during maintenance haemodialysis.
We describe the clinical course of a 39-year-old man who developed AIDS during maintenance haemodialysis. The infection had been transmitted by cadaveric kidney transplantation from a donor with a history of i.v. drug abuse. Fever, splenomegaly, hypergammaglobulinaemia and thrombocytopenia were the first signs, and appeared when haemodialysis was resumed 26 months after transplantation. Twenty-eight months later the patient developed a cerebral abscess due to toxoplasma infection. A striking improvement was obtained with cotrimoxazole, but the treatment had to be stopped because of severe leukopenia. The patient died due to relapse of the cerebral abscess. End-stage renal failure does not seem to have modified the clinical course of AIDS in our patient.
Imbasciati
E
E
Servizio di Nefrologia, Ospedale di Sondrio, Italy.
De Cristofaro
V
V
Samà
F
F
Pagliari
B
B
Baretta
A
A
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology / Q000635:transmission*; D000328:Adult; D001922:Brain Abscess / Q000209:etiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery / Q000628:therapy; D016030:Kidney Transplantation; D008297:Male; D006435:Renal Dialysis; D014123:Toxoplasmosis / Q000209:etiology