[Lipoprotein metabolism in patients with disordered thyroid gland function before and following therapy].
Clinical manifest hypothyreosis leads to changes of plasma lipoproteins, which are characterized by elevated LDL levels, an increase of the relation LDL cholesterol/HDL cholesterol, an elevation of the quotient cholesterol/triglycerides within the VLDL and an increase of the relation HDL2/HDL3. Both these changes and the diminished activities of post-heparin lipase of hepatic and extrahepatic origin are reversible after substitution therapy. On the contrary, patients with hyperthyreosis M. Basedow show low lipoprotein levels, high activities of post-heparin lipase and an elevation of the relation of the apolipoproteins apo C II/apo C III within the VLDL fraction.
Rassoul
F
F
Institut für Klinische Chemie, Karl-Marx-Universität, Leipzig.
Richter
V
V
Kuhlmann
E
E
Heberling
H J
HJ
Homann
M
M
Zuck
U
U
Rotzsch
W
W
Lohmann
D
D
D000328:Adult; D002784:Cholesterol / Q000097:blood; D005260:Female; D006111:Graves Disease / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000188:drug therapy; D008074:Lipoproteins / Q000097:blood*; D008875:Middle Aged; D013960:Thyroid Function Tests; D014280:Triglycerides / Q000097:blood
D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol
Lipoproteinstoffwechsel bei Patienten mit gestörter Schilddrüsenfunktion vor und nach Therapie.