Effects of minoxidil on blood pressure and cardiac hypertrophy in two-kidney, one-clip hypertensive rats.
Rats made severely hypertensive by renal arterial clipping were treated for 24 days with the arterial vasodilator minoxidil (40, 80, and 120 mg/L drinking water). In all three treated groups of animals, blood pressure initially decreased markedly and to a similar extent. Subsequently partial tolerance developed to the antihypertensive effects of minoxidil. All three doses induced hypertrophy of the right ventricle to a similar degree. In contrast, the hypertension-induced hypertrophy of the left ventricle was further increased in a dose-dependent fashion by minoxidil.
Fenje
P
P
Leenen
F H
FH
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D006332:Cardiomegaly / Q000209:etiology / Q000503:physiopathology*; D004326:Drinking / Q000187:drug effects; D006977:Hypertension, Renal / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008914:Minoxidil / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011743:Pyrimidines; D008914:Minoxidil