title: Cranial computerized tomography and cerebrospinal fluid procoagulant activity in childhood acute lymphoblastic leukemia.
abstract: Thirty-three children with acute lymphoblastic leukemia (ALL) were studied using serial cranial computerized tomography (CCT) and cerebrospinal fluid procoagulant activity (PCA) for 5 years from the time of diagnosis. PCA was also studied in control children without neurological disease and in those with a variety of neurological disorders. Temporary elevation in the CSF PCA was observed during the phase of prophylactic central nervous system treatment in ALL and there was a late rise at 2-3 years off treatment. PCA also rose in the CSF following CNS disturbance in neurologically abnormal children, which suggests that the elevation observed in ALL is not specific to myelin disturbance.
authors.affiliation: Department of Child Life and Health, University of Edinburgh, Scotland.
authors.forename: A E
authors.initials: AE
authors.lastname: O'Hare
authors.forename: O B
authors.initials: OB
authors.lastname: Eden
authors.forename: R M
authors.initials: RM
authors.lastname: Simpson
authors.forename: A
authors.initials: A
authors.lastname: Donaldson
authors.forename: C P
authors.initials: CP
authors.lastname: Sainsbury
mesh_terms: D001780:Blood Coagulation Tests; D001921:Brain / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000134:cerebrospinal fluid* / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed