Differential influence of 2'-deoxyguanosine on the induction and expression of suppressor T lymphocytes in vivo.
Subcutaneous (sc) immunization of mice with allogeneic spleen cells can induce delayed-type hypersensitivity (DTH) to histocompatibility antigens. Intravenous immunization with irradiated allogeneic spleen cells, on the other hand, induces suppressor T (Ts) lymphocytes. These Ts cells are capable of suppressing the host-versus-graft (HvG) DTH reactivity which normally arises after sc immunization. Moreover they can suppress the development of antihost DTH effector T cells during graft-versus-host (GvH) reactions. These models for HvG and GvH DTH reactivity were used to study the influence of 2'-deoxyguanosine (dGuo) on the induction, further development, and expression of Ts cells in vivo. It was found that administration of dGuo inhibits the proliferation-dependent induction and further development of Ts cells, but not the suppression mediated by already activated Ts cells.
Bril
H
H
van den Akker
T W
TW
Hussaarts-Odijk
L M
LM
Benner
R
R
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003849:Deoxyguanosine / Q000494:pharmacology*; D005260:Female; D006087:Graft vs Host Reaction / Q000187:drug effects*; D006789:Host vs Graft Reaction / Q000187:drug effects*; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007116:Immunization, Passive; D017710:Lymphocyte Transfusion; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D008811:Mice, Inbred DBA / Q000276:immunology; D011828:Radiation Chimera; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects*
D003849:Deoxyguanosine