Cardiovascular effects of new water-soluble derivatives of forskolin.
A series of 6- and 7-aminoacyl derivatives of 7-deacetylforskolin was prepared to provide water-soluble derivatives of the potent cardioactive diterpenoid forskolin. The compounds were evaluated for positive inotropic and blood pressure lowering properties in pharmacological models. Several derivatives displayed potent positive inotropic activity in guinea pig atria (EC50 = 0.16-3.0 micrograms/mL). In the most active compounds, the amino moiety of the aminoacyl chain corresponded to a cyclic amine, and the acyl moiety to a C2-C4 alkanoyl group. In vivo biological evaluation led to the selection of 6-(piperidinoacetyl)-7-deacetylforskolin hydrochloride (49) as a candidate for clinical development.
Khandelwal
Y
Y
Centre for Basic Research, Hoechst India Limited, Bombay.
Rajeshwari
K
K
Rajagopalan
R
R
Swamy
L
L
Dohadwalla
A N
AN
de Souza
N J
NJ
Rupp
R H
RH
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents; D002319:Cardiovascular System / Q000187:drug effects*; D002415:Cats; D005576:Colforsin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004285:Dogs; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D051379:Mice; D051381:Rats; D011918:Rats, Inbred SHR; D012995:Solubility; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship; D014867:Water
D002317:Cardiovascular Agents; D014867:Water; D005576:Colforsin