title: [Effect of 5,7-dihydroxytryptamine on pain sensitivity and analgesic activity of morphine].
abstract: Electron microscopy of rats ultrathin sections from dorsal and central raphe nucleus and spinal cord after 5,7-dihydroxytryptamine intracisternal microinjection (200 micrograms) has revealed neurones and axonal terminals distruction, which associated with tail-flick hypoalgesia and blood pressure nociceptive reactions diminished. In this condition the morphine (2 mg/kg) analgesia and drug depressive effect on pain hemodynamic manifestations increase significantly.
authors.forename: Iu D
authors.initials: IuD
authors.lastname: Ignatov
authors.forename: V A
authors.initials: VA
authors.lastname: Otellin
authors.forename: A A
authors.initials: AA
authors.lastname: Zaĭtsev
authors.forename: R P
authors.initials: RP
authors.lastname: Kucherenko
authors.forename: N V
authors.initials: NV
authors.lastname: Petriaevskaia
mesh_terms: D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000473:pathology; D004102:Dihydroxytryptamines / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects / Q000473:pathology
chemical_list: D004102:Dihydroxytryptamines; D015116:5,7-Dihydroxytryptamine; D009020:Morphine
vernacular_title: Vliianie 5,7-digidroksitriptamina na bolevuiu chuvstvitel'nost' i boleutoliaiushchee deĭstvie morfina.