Analgetic contribution of sufentanil during halothane anesthesia: a mechanism involving serotonin.
Catecholamine and serotonin concentrations in the cord, medulla, and hypothalamus were measured in rats after saline, after sufentanil sufficient to reduce the minimum alveolar concentration (MAC) of halothane by 30% or less, or after sufentanil sufficient to reduce the MAC of halothane by 80% or more. In the cord, high doses of sufentanil resulted in a 13.4% reduction (P less than 0.05) in serotonin concentration compared to saline control and a 17.4% reduction (P less than 0.05) in serotonin concentration compared to low dosages of sufentanil. A 12.8% reduction (P less than 0.05) in medullary serotonin also was observed with high sufentanil compared to low sufentanil. Epinephrine decreased significantly in the hypothalamus at the high sufentanil dose. No other significant differences were found in catecholamine content. The experimental results support the hypothesis that sufentanil may contribute to an analgetic component of general anesthesia by modulating nociception via the release of 5-HT.
Althaus
J S
JS
Miller
E D
ED
Moscicki
J C
JC
Hecker
B R
BR
DiFazio
C A
CA
D000700:Analgesics; D000769:Anesthesia, Inhalation; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D002490:Central Nervous System / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D006221:Halothane; D007031:Hypothalamus / Q000187:drug effects; D008526:Medulla Oblongata / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013116:Spinal Cord / Q000187:drug effects; D017409:Sufentanil
D000700:Analgesics; D002395:Catecholamines; D012701:Serotonin; D017409:Sufentanil; D005283:Fentanyl; D006221:Halothane; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine