title: Therapy of uncomplicated gonorrhea due to antibiotic-resistant Neisseria gonorrhoeae.
abstract: Antibiotics available to treat uncomplicated anogenital infections due to beta-lactamase-producing Neisseria gonorrhoeae include spectinomycin, ceftriaxone, and clavulanic acid added to aqueous procaine penicillin G or amoxicillin. Important variables in deciding which antibiotic regimen to use include effectiveness against urethral, cervical, pharyngeal, and rectal infections; cost; eradication of coexisting incubating syphilis; adverse effects; efficacy against strains of N. gonorrhoeae with chromosomally mediated resistance to antimicrobial agents; ease of administration; patient acceptance; and the potential for inducing resistance to antimicrobial agents in pathogens other than those causing sexually transmitted diseases. This review outlines the advantages and disadvantages of the various regimens.
authors.affiliation: Division of Sexually Transmitted Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
authors.forename: S J
authors.initials: SJ
authors.lastname: Kraus
authors.forename: G H
authors.initials: GH
authors.lastname: Reynolds
authors.forename: R T
authors.initials: RT
authors.lastname: Rolfs
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy* / Q000191:economics; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents