T-cell function in B-lymphocyte-deprived mice.
Previous work has identified selective defect(s) in T cells in mice deprived of B lymphocytes by the chronic administration of anti-IgM antibody. Experiments described in the present communication revealed that anti-IgM-treated mice do not possess T cells with surface Ia and FcR, and, unlike T cells from normal animals, they also fail to bind these molecules in vitro. Functional assays disclosed that an anti-suppressor pathway which relies on Ia+ donor and acceptor T cells is interrupted in these mice at both levels. These observations may provide an insight to explain the selective failure of some T cells when B lymphocytes have been deleted.
Gordon
J
J
Paraskevas
F
F
Lee
S T
ST
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008211:Lymphocyte Cooperation; D008222:Lymphokines / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000949:Histocompatibility Antigens Class II; D007075:Immunoglobulin M; D008222:Lymphokines; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors