Age and nature of operation influence the pharmacokinetics of midazolam.
The pharmacokinetics of midazolam were studied in surgical patients given 0.3 mg kg-1 i.v. for either the induction of anaesthesia, or postoperative sedation following cardiopulmonary bypass. The short elimination half-life of midazolam (2.4 h in patients less than 50 yr undergoing minor surgery) was significantly, although not markedly, prolonged with age (4.1 h in patients greater than 50 yr undergoing minor procedures) and by the nature of the operation (3.8 h after major operative procedures). These changes were the result of alterations in clearance and volume of distribution with age, and in volume of distribution with nature of operation.
Harper
K W
KW
Collier
P S
PS
Dundee
J W
JW
Elliott
P
P
Halliday
N J
NJ
Lowry
K G
KG
D000328:Adult; D000367:Age Factors; D000368:Aged; D000777:Anesthetics / Q000097:blood*; D001569:Benzodiazepines / Q000097:blood*; D002315:Cardiopulmonary Bypass; D005260:Female; D006207:Half-Life; D006801:Humans; D006993:Hypnotics and Sedatives / Q000097:blood*; D007700:Kinetics; D008297:Male; D008874:Midazolam; D008875:Middle Aged; D013514:Surgical Procedures, Operative
D000777:Anesthetics; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; D008874:Midazolam