Lactoferrin and C-reactive protein in response to cytostatic drugs with emphasis on methotrexate.
In this study plasma concentrations of lactoferrin (LF) and C-reactive protein (CRP) are examined in 9 children with different kinds of cancer but without any intercurrent infections. New, sensitive enzyme-linked immunosorbent assay for LF and CRP are described. The samples are drawn before, during, and after the cytotoxic drugs are given. The cytotoxic courses include cis-platinum, vincristine, adriamycin, cytarabine, and methotrexate (6 g/m2/24 h and 33.6 g/m2/24 h). During the infusion of methotrexate 33.6 g/m2 the concentrations of LF are increased, only a small increase of CRP is observed, and for the other groups there is no changes of both parameters.
Gutteberg
T J
TJ
Department of Pediatrics, University Hospital of Tromsø, Norway.
Slørdal
L
L
Kolmannskog
S
S
D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007781:Lactoferrin / Q000032:analysis*; D008727:Methotrexate / Q000494:pharmacology*; D009369:Neoplasms / Q000097:blood* / Q000188:drug therapy; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*
D000970:Antineoplastic Agents; D015415:Biomarkers; D002097:C-Reactive Protein; D007781:Lactoferrin; D008727:Methotrexate