Interferon in chronic active hepatitis B. Preliminary results.
Twenty patients with documented chronic active hepatitis B were randomized in equal numbers to either an alpha-2b interferon treatment group or a control group with no treatment. Patients in the first group received 5 IU interferon three times weekly by subcutaneous injection for 16 weeks. All 20 patients were HBeAg positive at the beginning. All 10 patients in the interferon-treated group lost their initial e antigen while only 2 patients in the control group turned HBeAg negative. Six patients in the treated group acquired HBe antibodies in comparison with two patients only in the untreated group. Other markers of suppression of viral replication as well as a 24-month follow-up are ongoing at the moment for final assessment of the value of interferon therapy in chronic active hepatitis B.
Waked
I
I
Department of Medicine and Clinical Pathology, Ain-Shams University, Cairo, Egypt.
Amin
M
M
Abd-el Fattah
S A
SA
Osman
L
L
Sabbour
M
M
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D005260:Female; D006509:Hepatitis B / Q000628:therapy*; D006513:Hepatitis B e Antigens / Q000032:analysis*; D006521:Hepatitis, Chronic / Q000628:therapy*; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation
D006513:Hepatitis B e Antigens; D007370:Interferon Type I