Clinical investigation of olfactory and auditory function in type I pseudohypoparathyroidism: participation of adenylate cyclase system.
Olfactory and auditory function was examined in five patients with type I pseudohypoparathyroidism; in two patients the activity of stimulatory guanine nucleotide-binding protein was examined and found to have low values. The olfactory tests were performed by T & T olfactometer and intravenous injection of thiamine propyl disulphide. The four patients receiving olfactory test showed a disturbance in recognization of the odorants. All five patients had normal hearing at frequencies with the normal range. An adenylate cyclase system is thought to play an important role in olfactory transduction, whereas cochlear function may be unaffected by this system in the normal state.
Ikeda
K
K
Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.
Sakurada
T
T
Sasaki
Y
Y
Takasaka
T
T
Furukawa
Y
Y
D000262:Adenylyl Cyclases / Q000502:physiology*; D001299:Audiometry; D001301:Audiometry, Pure-Tone; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008297:Male; D011547:Pseudohypoparathyroidism / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology*; D012903:Smell
D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases