Phenobarbital-induced Tourette-like symptoms.
A 7-year-old child with spastic cerebral palsy and a seizure disorder developed Tourette-like symptoms during therapy with phenobarbital. These symptoms occurred while phenobarbital blood levels were in the therapeutic range. Known causes of movement disorders were eliminated after evaluation. On repeat challenge with phenobarbital, the symptoms recurred. Phenobarbital should be added to the list of drugs that cause Tourette-like symptoms.
Sandyk
R
R
Department of Internal Medicine (Neurology), University of Arizona Health Sciences Center, Tucson 85724.
D002547:Cerebral Palsy / Q000150:complications*; D002648:Child; D004832:Epilepsy, Absence / Q000188:drug therapy*; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects* / Q000627:therapeutic use; D005879:Tourette Syndrome / Q000139:chemically induced*
D010634:Phenobarbital