title: PaO2 increases with coughing in patients with chronic lung disease.
abstract: We considered if the cyanosis frequently observed during a cough attack in patients with chronic lung disease was due to worsening hypoxemia. To investigate the effects of cough on PaO2, we measured arterial blood gases before and after a voluntary coughing period of 45 sec, in 11 patients with Interstitial Lung Disease (ILD) and 14 patients with Chronic Obstructive Lung Disease (COPD). All patients significantly increased (p less than 0.05) their PaO2 (COPD: from 49 +/- 2 to 60 +/- 2 mmHg; ILD from 44 +/- 2 to 51 +/- 3 mmHg, mean +/- SD) and decreased their PaCO2. We conclude that stable patients with COPD and ILD increase their PaO2 with coughing most likely due to hyperventilation. The cyanosis observed could be due to peripheral circulatory effects of coughing.
authors.affiliation: Cardiopulmonary Service, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico.
authors.forename: W
authors.initials: W
authors.lastname: Martinez
authors.forename: J
authors.initials: J
authors.lastname: Sandoval
authors.forename: R
authors.initials: R
authors.lastname: Perez-Padilla
authors.forename: R
authors.initials: R
authors.lastname: Maxwell
authors.forename: M
authors.initials: M
authors.lastname: Seoane
authors.forename: E
authors.initials: E
authors.lastname: Lupi-Herrera
mesh_terms: D000328:Adult; D000368:Aged; D002245:Carbon Dioxide / Q000097:blood; D003371:Cough / Q000097:blood*; D003490:Cyanosis / Q000209:etiology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008173:Lung Diseases, Obstructive / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D011658:Pulmonary Fibrosis / Q000097:blood*
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen