Studies on zoapatle. VIII: Novel cytotoxic sesquiterpene lactones from Montanoa tomentosa ssp. microcephala.
Investigation of the leaves of Montanoa tomentosa Cerv. ssp. microcephala (Sch.-Bip.) Funk (Compositae) resulted in the isolation of three novel guaianolide sesquiterpenes, montacephalin (1), tomencephalin (2), and 5-hydroxytomencephalin (3), which were shown to be cytotoxic (P-388). The structures of these sesquiterpenes were elucidated through analysis of their spectroscopic characteristics, and complete proton and carbon-13 assignments were made for the new compounds. Also isolated were the known terpenes, beta-amyrin, beta-amyrin acetate, stigmasterol, stigmasterol-3 beta-D-glucoside, (-)-kaur-16-en-19-oic acid, and monoginoic acid.
Topcu
G
G
Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612.
Cordell
G A
GA
Farnsworth
N R
NR
Fong
H H
HH
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D007941:Leukemia P388 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000032:analysis*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology
D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D012717:Sesquiterpenes; C057283:montacephalin; C057284:tomencephalin; C057285:5-hydroxytomacephalin