title: Allopurinol hypersensitivity in a patient with coexistent systemic lupus erythematosus and tophaceous gout.
abstract: A patient with coexistent Klinefelter's syndrome, systemic lupus erythematosus (SLE) and chronic tophaceous gouty arthritis developed allopurinol hypersensitivity. The drug was reinstituted by a schedule of gradually increasing doses. Gout should be considered in the differential diagnosis of patients with SLE who present with acute arthritis and/or subcutaneous nodules particularly in those with longstanding stable nephritis who are receiving diuretics for concomitant hypertension.
authors.affiliation: Department of Medicine, Sunnybrook Medical Centre, University of Toronto, ON, Canada.
authors.forename: J
authors.initials: J
authors.lastname: McDonald
authors.forename: A G
authors.initials: AG
authors.lastname: Fam
authors.forename: T
authors.initials: T
authors.lastname: Paton
authors.forename: J
authors.initials: J
authors.lastname: Senn
mesh_terms: D000328:Adult; D000493:Allopurinol / Q000009:adverse effects* / Q000627:therapeutic use; D001175:Arthrography; D004342:Drug Hypersensitivity / Q000150:complications*; D005385:Fingers / Q000000981:diagnostic imaging; D006073:Gout / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D014527:Uric Acid / Q000378:metabolism*
chemical_list: D014527:Uric Acid; D000493:Allopurinol