[Effect of drugs on granulocyte motility].
The in-vitro influence of drugs on the chemokinesis and chemotaxis of neutrophils was investigated in order to prevent additional drug-induced motility impairment of cells in cases of already existing host defense disorders and for an eventual specific treatment of motility defects. Granulocyte motility is unimpaired by penicillin, ampicillin, carbenicillin, streptomycin, nystatin, and cyclophosphamide. The chemokinesis and chemotaxis of neutrophils are inhibited by erythromycin, oxytetracycline, doxycycline, chloramphenicol, hydrocortisone, g-strophanthin, digoxin, and digitoxin and in higher concentrations also by sulfonamides, gentamycin, prednisolone, methylprednisolone, dexamethasone, and phenylbutazone. Chemotaxis is selectively or rather more inhibited than chemokinesis by amphotericin B, griseofulvin, vinblastine++, trifluoperazine, and promethazine. Granulocyte motility is, however, stimulated by ascorbic acid, potassium thiocyanate, levamisole, lithium, and metofenazate.
Schmidt
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Morenz
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D000871:Anthelmintics / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D002301:Cardiac Glycosides / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003520:Cyclophosphamide / Q000494:pharmacology; D006801:Humans; D010640:Phenothiazines / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology; D014747:Vinblastine / Q000494:pharmacology
D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D002301:Cardiac Glycosides; D010640:Phenothiazines; D013449:Sulfonamides; C008520:metofenazate; D014747:Vinblastine; D003520:Cyclophosphamide
Einfluss von Arzneimitteln auf die Granulozytenmotilität.