title: [T lymphocyte activation induced in vivo by the first injection of OKT3 monoclonal antibodies].
abstract: One of the major side effects induced by the in vivo administration of the murine monoclonal antibody OKT3 is a spontaneously reversible clinical syndrome associating in variable proportions depending on the patient: fever, chills, headaches, diarrhea and seldomly meningismus. Sera from 3 renal allograft recipients treated with OKT3 were studied and showed that a massive although transient release of some cytokines namely, Tumor Necrosis Factor alpha, Interleukin 2 and Interferon gamma is observed following the first OKT3 injection.
authors.affiliation: Hôpital Necker, Paris.
authors.forename: L
authors.initials: L
authors.lastname: Chatenoud
authors.forename: C
authors.initials: C
authors.lastname: Ferran
authors.forename: A
authors.initials: A
authors.lastname: Reuter
authors.forename: C
authors.initials: C
authors.lastname: Legendre
authors.forename: Y
authors.initials: Y
authors.lastname: Gevaert
authors.forename: H
authors.initials: H
authors.lastname: Kreis
authors.forename: P
authors.initials: P
authors.lastname: Franchimont
authors.forename: J F
authors.initials: JF
authors.lastname: Bach
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D016030:Kidney Transplantation; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma
vernacular_title: Activation lymphocytaire T induite in vivo par la première injection de l'anticorps monoclonal OKT3.