title: A prospective randomized trial of alpha 2B-interferon/gamma-interferon or the combination in advanced metastatic renal cell carcinoma.
abstract: Eighty-nine patients with advanced measurable metastatic renal cell carcinoma were entered into a prospective randomized trial comparing alpha-interferon to gamma-interferon and to the combination. The trial was performed in order to confirm the activity of gamma-interferon and assess the potential clinical synergism. Response rates were 5, 10, and 5%, respectively. The low response rate may have been due to the inability to raise the doses of the interferons to higher levels. Clinical synergy at this dose, route, and schedule of administration in renal cell carcinoma does not exist.
authors.affiliation: University of Michigan, Ann Arbor.
authors.forename: K
authors.initials: K
authors.lastname: Foon
authors.forename: J
authors.initials: J
authors.lastname: Doroshow
authors.forename: E
authors.initials: E
authors.lastname: Bonnem
authors.forename: A
authors.initials: A
authors.lastname: Fefer
authors.forename: S
authors.initials: S
authors.lastname: Graham
authors.forename: B
authors.initials: B
authors.lastname: Grosh
authors.forename: P
authors.initials: P
authors.lastname: Narayan
authors.forename: L
authors.initials: L
authors.lastname: Elias
authors.forename: H
authors.initials: H
authors.lastname: Harvey
authors.forename: R
authors.initials: R
authors.lastname: Schulof
mesh_terms: D002292:Carcinoma, Renal Cell / Q000556:secondary* / Q000628:therapy; D004359:Drug Therapy, Combination; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000627:therapeutic use*; D011994:Recombinant Proteins
chemical_list: D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D007371:Interferon-gamma