The subrenal capsule: an alternative site for the maintenance of normal and preneoplastic urothelium.
Implantation of normal bladder mucosa beneath the kidney capsule of a syngeneic animal, results in a heterotopic bladder lined by a one to three cell layer of urothelium. This cystic structure can be maintained for greater than 90 days and displays many of the differentiation characteristics of a normal bladder, both at the light and electron microscopy level. Preneoplastic urothelial cells behave in a similar manner recreating a heterotopic bladder lined by urothelium displaying aberrant differentiation and surface morphology. All tumorigenic cell lines tested in this model produced solid tumor growth within a few weeks. The subrenal capsule represents an alternative site for the reconstitution of urothelial material at different stages of neoplastic progression.
Joyce
A D
AD
New England Deaconess Hospital, Department of Surgery, Harvard Medical School, Boston, Massachusetts.
Bulovas
K M
KM
Summerhayes
I C
IC
D000818:Animals; D002460:Cell Line; D004847:Epithelial Cells; D051379:Mice; D008854:Microscopy, Electron; D009092:Mucous Membrane / Q000637:transplantation; D013370:Subrenal Capsule Assay; D001743:Urinary Bladder / Q000166:cytology