Comparative studies of fleroxacin and ofloxacin in experimental pyelonephritis.
Two quinolones, fleroxacin and ofloxacin were used as oral treatment in a model of experimental pyelonephritis in rats. The infecting strains were Escherichia coli, Klebsiella oxytoca and Pseudomonas aeruginosa. Compared to untreated control rats, the rats treated with the quinolones showed a great reduction in bacterial counts in kidney tissue and urine. At lower dosages, fleroxacin had a greater bacterial killing effect than ofloxacin.
Ritzerfeld
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Institute of Medical Microbiology WWU, Muenster, West Germany.
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D016576:Fleroxacin; D006207:Half-Life; D007709:Klebsiella / Q000187:drug effects; D015242:Ofloxacin / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011704:Pyelonephritis / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D015242:Ofloxacin; D016576:Fleroxacin