title: Conjunctival biopsy in Sjögren's syndrome: correlations between histological and immunohistochemical features.
abstract: We have examined conjunctival biopsies from nine primary and two secondary cases of Sjögren's syndrome. In all cases histopathological examination revealed metaplasia of the conjunctival epithelium associated with a reduced number of goblet cells and a polymorphic inflammatory cell infiltrate of the stroma. Using monoclonal antibodies with texture analysis of stained preparations we have shown that in all cases the lymphocytic infiltrate was predominantly T-cell but with substantial numbers of IgA and IgG secretory B-cells in three cases. The number of Langerhans cells present was reduced in biopsies showing the most marked degree of epithelial metaplasia.
authors.affiliation: Département d'Hématologie, Chu Pitié-Salpétrière, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Raphael
authors.forename: S
authors.initials: S
authors.lastname: Bellefqih
authors.forename: J C
authors.initials: JC
authors.lastname: Piette
authors.forename: P
authors.initials: P
authors.lastname: Le Hoang
authors.forename: P
authors.initials: P
authors.lastname: Debre
authors.forename: G
authors.initials: G
authors.lastname: Chomette
mesh_terms: D000328:Adult; D000368:Aged; D003228:Conjunctiva / Q000276:immunology / Q000473:pathology*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000473:pathology; D008214:Lymphocytes / Q000145:classification / Q000276:immunology / Q000473:pathology; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000276:immunology / Q000473:pathology*