[Effect of calmodulin inhibitors on the contraction and relaxation of the heart muscle].
The calmodulin inhibitor trifluoroperazine (5 microM) diminished the velocity of contraction and relaxation of the guinea-pig papillary muscle by 31 and 53%, respectively. Methophenazine showed approximately the same affinity to both calmodulin and trifluoroperazine and nearly 40-fold less affinity to troponin. Methophenazine (5 microM) did not change the contraction velocity and diminished the relaxation velocity ty 21%. It is suggested that calmodulin participates mainly in the control of myocardial relaxation.
Kapel'ko
V I
VI
Gorina
M S
MS
Men'shikov
M Iu
MIu
Tkachuk
V A
VA
D000205:Actomyosin / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects / Q000201:enzymology; D010640:Phenothiazines / Q000378:metabolism / Q000494:pharmacology; D014268:Trifluoperazine / Q000378:metabolism / Q000494:pharmacology; D014336:Troponin / Q000037:antagonists & inhibitors; D019209:Troponin C
D002147:Calmodulin; D010640:Phenothiazines; D014336:Troponin; D019209:Troponin C; D014268:Trifluoperazine; C008520:metofenazate; D000205:Actomyosin; D000251:Adenosine Triphosphatases
Vliianie ingibitorov kal'modulina na sokrashchenie i rasslablenie serdechnoĭ myshtsy.