Changes in serum lipids in patients with condylomata acuminata treated with interferon alfa-n1 (Wellferon).
Nine men with refractory condylomata acuminata were treated with intramuscular interferon alfa-n1 and the effect on their serum lipid levels was noted. Comparison of lipid panels before and after interferon revealed that all nine patients had an increase (median 62 mg/dl, p = 0.004) in their triglyceride level and a decrease (median 21 mg/dl, p = 0.004) in high-density lipoprotein cholesterol levels. Total cholesterol levels tended to decrease but the change was not statistically significant. This effect on serum lipids should be considered when interferon alfa-n1 is used in the treatment of genital warts.
Olsen
E A
EA
Duke University Medical Center, Department of Medicine, Durham, NC 27710.
Lichtenstein
G R
GR
Wilkinson
W E
WE
D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003218:Condylomata Acuminata / Q000628:therapy*; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D014280:Triglycerides / Q000097:blood*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D007370:Interferon Type I; D014280:Triglycerides; D002784:Cholesterol