[Acute fatal hepatorenal failure during treatment with mithramycin].
A case of fatal hepato-renal failure occurring during mithramycin treatment is reported. A 64 year-old female patient was admitted to hospital in a state of acute renal failure. She also presented with hypercalcaemia and bilateral pulmonary metastases. She had been operated on 10 years previously of a parathyroid cancer. Despite treatment with mithramycin (total dose 8.25 mg) and haemodialysis, the hypercalcaemia returned; it was then decided to remove the secretory lung metastases (parathormone 420 micrograms X ml-1). 48 hours before surgery, the patient was again given 1.25 mg mithramycin. Immediately after surgery, she developed hepatic failure with massive cell destruction and anuria. The patient died 48 h after the operation. The hepatic and renal complications of mithramycin are discussed.
Hémon
Y
Y
Martin
C
C
Auffray
J P
JP
Bonneru
J J
JJ
Brunet
C
C
Farisse
J
J
D058186:Acute Kidney Injury / Q000139:chemically induced*; D002118:Calcium / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy / Q000209:etiology; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000150:complications; D008926:Plicamycin / Q000009:adverse effects* / Q000627:therapeutic use
D003404:Creatinine; D008926:Plicamycin; D002118:Calcium
Insuffisance hépato-rénale aiguë mortelle au cours d'un traitement par la mithramycine.