title: Gemfibrozil in the treatment of resistant familial hypercholesterolaemia and type III hyperlipoproteinaemia.
abstract: The efficacy of gemfibrozil in the treatment of resistant familial hypercholesterolaemia and type III hyperlipoproteinaemia was evaluated in 26 individuals over a mean period of 16 months. In the untreated state both disorders are associated with a high frequency of coronary heart disease. In the former, gemfibrozil with a bile acid sequestrant reduced plasma cholesterol by 32%, an incremental decrease of 17% compared with sequestrant therapy alone. In type III, plasma cholesterol was reduced by 40% and plasma triglyceride by 70%, while high-density lipoprotein cholesterol increased by 45%. In none of the patients studied did clinical or biochemical side effects occur.
authors.affiliation: Division of Chemical Pathology and Metabolic Disorders, United Medical School, St Thomas' Hospital, London.
authors.forename: R
authors.initials: R
authors.lastname: Houlston
authors.forename: J
authors.initials: J
authors.lastname: Quiney
authors.forename: G F
authors.initials: GF
authors.lastname: Watts
authors.forename: B
authors.initials: B
authors.lastname: Lewis
mesh_terms: D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D002792:Cholestyramine Resin / Q000627:therapeutic use; D003084:Colestipol / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D015248:Gemfibrozil; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000188:drug therapy*; D006952:Hyperlipoproteinemia Type III / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D010421:Pentanoic Acids / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood; D014631:Valerates / Q000627:therapeutic use*
chemical_list: D008076:Cholesterol, HDL; D000960:Hypolipidemic Agents; D010421:Pentanoic Acids; D014280:Triglycerides; D014631:Valerates; D002792:Cholestyramine Resin; D002784:Cholesterol; D003084:Colestipol; D015248:Gemfibrozil