title: Three consecutive primary malignancies in one patient during childhood.
abstract: Patients with a primary immunodeficiency syndrome have an increased risk of developing a malignancy. Lymphoreticular malignancies are the most common malignancies in these patients. Patients with ataxia telangiectasia (AT) also appear to be at a high risk for the development of nonlymphoid tumors--in particular, carcinomas of the gastrointestinal tract and central nervous system tumors. We describe a child with an immunodeficiency and slight neurological manifestations. During childhood she developed three consecutive primary malignancies.
authors.affiliation: Department of Pediatric Oncology, Emma Kinderziekenhuis, Amsterdam, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Groot-Loonen
authors.forename: R
authors.initials: R
authors.lastname: Slater
authors.forename: J
authors.initials: J
authors.lastname: Taminiau
authors.forename: P A
authors.initials: PA
authors.lastname: Voûte
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology; D001254:Astrocytoma / Q000276:immunology; D001932:Brain Neoplasms / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000276:immunology; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D012811:Sigmoid Neoplasms / Q000276:immunology