Nontoxic concentration of amphotericin B for intravitreal use--evaluated by in vitro ERG.
Amphotericin B (AMPH)-induced changes of the electroretinogram (ERG) were studied in the in vitro eye-cup of the albino rabbit. The a-wave, b-wave, oscillatory potentials and c-wave were not changed by 1 microM AMPH, and these all were slightly suppressed by 5 microM AMPH. These changes were mostly reversible. The b-wave and oscillatory potentials were greatly suppressed by 50 microM AMPH. These changes were only partially reversible 75 minutes after re-perfusion without AMPH.
Kawasaki
K
K
Department of Ophthalmology Kanazawa University School of Medicine, Japan.
Ohnogi
J
J
Okayama
Y
Y
D000666:Amphotericin B / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D004596:Electroretinography; D066298:In Vitro Techniques; D007267:Injections; D009994:Osmolar Concentration; D010477:Perfusion; D011817:Rabbits; D012160:Retina / Q000187:drug effects*; D014822:Vitreous Body
D000666:Amphotericin B