The liver peptides after chronic administration of ethanol in rats.
The liver peptide fractions labelled with 3H-arginine after chronic administration of ethanol to rats have been analysed by gel filtration chromatography and tlc. Specific 3H-arginine radioactivity in the liver peptide fraction calculated per micrograms of alpha-amino nitrogen was significantly decreased by alcohol. The amount of peptide spots obtained by tlc in the ethanol-treated group was reduced in comparison with the control group. The findings suggest a change in the protein metabolism in hepatic dysfunction in rats receiving ethanol over a prolonged period.
Farbiszewski
R
R
Department of Inorganic and Analytical Chemistry, Medical Academy, Bialystok, Poland.
Gabryel
H
H
D000437:Alcoholism / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001120:Arginine / Q000378:metabolism; D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D008099:Liver / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D010455:Peptides / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D010455:Peptides; D011506:Proteins; D001120:Arginine