Induction of IgA-specific suppressor activity in human T-lymphocyte cultures.
Cell-free supernatants of human circulating T-lymphocyte cultures incubated with secretory IgA (S-IgA) specifically suppressed both spontaneous IgA synthesis by B lymphocytes isolated from allergic individuals and pokeweek mitogen-induced IgA secretion by peripheral blood mononuclear cells. Cell-free supernatants of T-cell cultures incubated with IgE had no effect on IgA, IgG, or IgM synthesis. Hence, it is concluded that upon incubation with S-IgA, but not with another Ig class, T lymphocytes release IgA-specific suppressor factors.
Sarfati
M
M
Rubio-Trujillo
M
M
Wong
K
K
Perry
J
J
Sehon
A H
AH
Delespesse
G
G
D000918:Antibody Specificity; D002474:Cell-Free System; D002478:Cells, Cultured; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000276:immunology*; D007071:Immunoglobulin A, Secretory / Q000494:pharmacology; D008214:Lymphocytes / Q000378:metabolism; D011863:Radioimmunoassay; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory