title: Measurement of parathyrin in blood from thyroid veins: two radioimmunoassays compared in patients with primary hyperparathyroidism.
abstract: We measured parathyrin (PTH) in peripheral venous blood samples and in thyroid veins (both homolateral and contralateral to the lesion) in 13 patients with surgically confirmed parathyroid adenomas. Two different RIAs were used, one specific to the mid-region of the molecule (44-68, M-PTH), the other specific to the carboxy-terminal region (65-84, C-PTH). With the M-PTH assay we established a statistically significant multiple correlation (P less than 0.05) between the PTH concentrations in blood from the peripheral and thyroid veins; no significant correlation was found when we used the C-PTH assay. Our results confirm the superiority of the M-PTH RIA over the C-PTH RIA for study of hormonal secretion in primary hyperparathyroidism.
authors.affiliation: Department of Medicine, (Endocrinology Division), University Hospital, Granada, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Muñoz-Torres
authors.forename: J
authors.initials: J
authors.lastname: Diaz
authors.forename: F
authors.initials: F
authors.lastname: Escobar-Jimenez
authors.forename: G
authors.initials: G
authors.lastname: Gonzalez-Calvin
authors.forename: C
authors.initials: C
authors.lastname: Vara
authors.forename: M E
authors.initials: ME
authors.lastname: Ruiz Requena
authors.forename: R
authors.initials: R
authors.lastname: Vara
authors.forename: I
authors.initials: I
authors.lastname: Morales
mesh_terms: D000328:Adult; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood*; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D011863:Radioimmunoassay; D013961:Thyroid Gland / Q000098:blood supply*; D014680:Veins
chemical_list: D010281:Parathyroid Hormone