Immunological alterations in a case of Papillon-Lefèvre syndrome with recurrent cutaneous infections.
An immunological study was performed in a 16-year-old boy affected with Papillon-Lefèvre syndrome (PLS) and recurrent staphylococcal cutaneous infections. A defect of neutrophil intracellular killing of Staphylococcus aureus and a decreased lymphocyte proliferative response to phytohaemagglutinin were detected. The possible role of these alterations in promoting recurrent infections in PLS is discussed.
Borroni
G
G
Pagani
A
A
Carcaterra
A
A
Pericoli
R
R
Gabba
P
P
Marconi
M
M
D000293:Adolescent; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000276:immunology*; D008297:Male; D009504:Neutrophils / Q000276:immunology; D010214:Papillon-Lefevre Disease / Q000276:immunology*; D012008:Recurrence; D012874:Skin Diseases, Infectious / Q000276:immunology*; D013203:Staphylococcal Infections / Q000276:immunology