title: Experimental infections of the musculoskeletal system: evaluation with MR imaging and Tc-99m MDP and Ga-67 scintigraphy.
abstract: Acute osteomyelitis, soft-tissue infection, or both were experimentally produced in 38 New Zealand white rabbits, and three-phase technetium-99m methylene diphosphonate, gallium-67, and magnetic resonance (MR) images were obtained 7 or 14 days after infection. There was no significant difference between radionuclide studies and MR images in the detection of osteomyelitis, but MR imaging was significantly more sensitive (100% vs. 69%; P less than .01) in the detection of soft-tissue infection. In addition, cellulitis could not be distinguished from soft-tissue abscess on radionuclide studies, whereas MR imaging was 92% accurate in depicting soft-tissue abscesses. Further research is necessary to determine how to relate these findings to true human clinical situations.
authors.affiliation: Department of Radiology, College of Veterinary Medicine, Ohio State University Hospitals, Columbus 43210.
authors.forename: J
authors.initials: J
authors.lastname: Beltran
authors.forename: R B
authors.initials: RB
authors.lastname: McGhee
authors.forename: P B
authors.initials: PB
authors.lastname: Shaffer
authors.forename: J O
authors.initials: JO
authors.lastname: Olsen
authors.forename: W F
authors.initials: WF
authors.lastname: Bennett
authors.forename: T R
authors.initials: TR
authors.lastname: Foster
authors.forename: M S
authors.initials: MS
authors.lastname: McCalla
authors.forename: L A
authors.initials: LA
authors.lastname: Iskra
authors.forename: R L
authors.initials: RL
authors.lastname: Blagg
authors.forename: D S
authors.initials: DS
authors.lastname: Biller
mesh_terms: D000038:Abscess / Q000175:diagnosis*; D000818:Animals; D002481:Cellulitis / Q000175:diagnosis*; D005710:Gallium Radioisotopes; D008279:Magnetic Resonance Imaging; D010019:Osteomyelitis / Q000175:diagnosis*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000175:diagnosis*; D013669:Technetium Tc 99m Medronate; D014057:Tomography, X-Ray Computed
chemical_list: D005710:Gallium Radioisotopes; D013669:Technetium Tc 99m Medronate