Relationship between serum dehydroepiandrosterone sulphate and urinary 17-ketosteroid values.
To assess the validity of serum dehydroepiandrosterone sulphate (DS) radioimmunoassay instead of urinary total 17-ketosteroid (17-KS) or individual metabolite (dehydroepiandrosterone + etiocholanolone + androsterone; D + E + A) determination to control adrenal androgen function, a comparative study has been performed. Mathematical analysis of simultaneous estimates revealed significant correlation when normal or above normal 17-KS or D + E + A excretion relative to serum DS were considered. Poor correlation was observed when below normal metabolite excretion and serum DS were related. Furthermore, there was a significant correlation between estimates of 17-KS (or D + E + A) and those of serum unconjugated D also determined by radioimmunoassay. The serum DS radioimmunoassay appeared to be a reliable tool to assess adrenal androgen function, at least in patients exhibiting normal or high 17-ketosteroid values.
Fehér
T
T
Poteczin
E
E
Bodrogi
L
L
D015068:17-Ketosteroids / Q000652:urine*; D000293:Adolescent; D000311:Adrenal Glands / Q000502:physiology; D000328:Adult; D000368:Aged; D000728:Androgens / Q000502:physiology; D000738:Androsterone / Q000652:urine; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood / Q000652:urine; D019314:Dehydroepiandrosterone Sulfate; D005043:Etiocholanolone / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D015068:17-Ketosteroids; D000728:Androgens; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D005043:Etiocholanolone; D000738:Androsterone