[Blocking calcium-dependent potassium in permeability of skeletal muscle fibers in the frog by a sodium-free medium].
In voltage-clamped frog muscle fibres, the total or partial substitution of NaCl by LiCl does not alter the calcium-dependent slow outward potassium current. In contrast, an equimolar substitution of NaCl by choline-Cl (+atropine) or trisCl induces a rapid and reversible blockage of the current.
Nasri-Sebdani
M
M
Laboratoire de Physiologie Générale, U.A. C.N.R.S. n. 290, U.F.R. Sciences, Poitiers.
Cognard
C
C
Potreau
D
D
Raymond
G
G
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002147:Calmodulin / Q000502:physiology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D002794:Choline / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008094:Lithium / Q000494:pharmacology; D009132:Muscles / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D011898:Ranidae; D012964:Sodium / Q000494:pharmacology*
D002147:Calmodulin; D008094:Lithium; D012964:Sodium; D002794:Choline; D011188:Potassium
Blocage de la perméabilité potassique calcium-dépendante de la fibre musculaire squelettique de Grenouille par un milieu sans sodium.