Effects of a single oral dose of dinitrochlorobenzene on T lymphocyte distribution and migration in the gut.
In the present study the effects of a large oral dose of the contact allergen dinitrochlorobenzene (DNCB) on the distribution of T-cell subsets in the small intestines and the emigration pattern of lymphocytes from Peyer's patches were investigated. Apart from the inflammatory effects, DNCB administration resulted in an influx on the T-helper cells in the villi. Precise quantification of T lymphocytes showed a decrease in Peyer's patches and an increase in mesenteric lymph node cell suspensions. However, no differences could be found in the emigration rate of T-cell subsets from Peyer's patches into mesenteric lymph nodes, suggesting that the increase of T cells in mesenteric lymph nodes results from T-helper cells directly immigrating from the villi.
Jeurissen
S H
SH
Schmidt
E D
ED
Sminia
T
T
Kraal
G
G
D000485:Allergens / Q000008:administration & dosage*; D000818:Animals; D002465:Cell Movement; D004137:Dinitrochlorobenzene / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology; D007421:Intestine, Small / Q000166:cytology / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D008297:Male; D009578:Nitrobenzenes / Q000276:immunology*; D010581:Peyer's Patches / Q000166:cytology / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000145:classification / Q000166:cytology / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology
D000485:Allergens; D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes