title: 24-hour cyclophosphamide infusion therapy for malignant mesothelioma of the pleura.
abstract: Thirteen patients with malignant mesothelioma of the pleura have been treated with 24-hour cyclophosphamide infusion (2.5 g/m2) therapy. There were no complete responders. Three patients (23%) had a partial response, and a further three patients who did not fulfil the criteria for objective response, had subjective benefit from therapy with increase in performance status. The overall median survival from the onset of therapy was 6 months (range 2-19 months). High dose cyclophosphamide offers no advantage over standard dose therapy.
authors.affiliation: CRC Department of Medical Oncology, Christie Hospital, Manchester.
authors.forename: H
authors.initials: H
authors.lastname: Anderson
authors.forename: P
authors.initials: P
authors.lastname: Hasleton
authors.forename: A B
authors.initials: AB
authors.lastname: Michie
authors.forename: R J
authors.initials: RJ
authors.lastname: Johnson
authors.forename: N
authors.initials: N
authors.lastname: Thatcher
mesh_terms: D000328:Adult; D000368:Aged; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008654:Mesothelioma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011859:Radiography
chemical_list: D003520:Cyclophosphamide