Adrenal renin: a possible local hormonal regulator of aldosterone production.
The complete renin-angiotensin system is present in the adrenal cortex: prorenin, renin, angiotensinogen, angiotensin I and II, and converting enzyme. Most of the renin found is probably synthesized there since the renin concentration increases after nephrectomy, and the mRNA for renin is present. The renin-angiotensin system has the highest activity in the zona glomerulosa cells, the site of aldosterone formation. A low-sodium diet or a high-potassium diet, or nephrectomy markedly increases the adrenal renin concentration in the zona glomerulosa cells without any effect on the fasciculata-medullary cells. There is a close correlation between adrenal renin and aldosterone production. The adrenal renin angiotensin system may be a local regulator of aldosterone production.
Mulrow
P J
PJ
Department of Internal Medicine and Pathology, Medical College of Ohio, Toledo 436991.
Kusano
E
E
Baba
K
K
Shier
D
D
Doi
Y
Y
Franco-Saenz
R
R
Stoner
G
G
Rapp
J
J
D000311:Adrenal Glands / Q000378:metabolism / Q000502:physiology*; D000450:Aldosterone / Q000096:biosynthesis*; D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000502:physiology*
D000450:Aldosterone; D012083:Renin