[Gold-induced systemic lupus erythematosus].
After 10 months of treatment with sodiumaureo-thiomalate a 12 year old girl with severe exsudative polyarthritis developed pericarditis and high titers of antinuclear antibodies as well as antibodies to native double-stranded DNA. At that time the cumulative gold dose was 550 mg. After withdrawal of gold medication the clinical symptoms rapidly disappeared and did not recur after a follow-up period of now 5 years. The titers of autoantibodies decreased to normal levels within a year.
Körholz
D
D
Zentrum für Kinderheilkunde, Universität Düsseldorf.
Nürnberger
W
W
Göbel
U
U
Wahn
V
V
D000974:Antibodies, Antinuclear / Q000032:analysis*; D001171:Arthritis, Juvenile / Q000188:drug therapy*; D002648:Child; D005260:Female; D006052:Gold Sodium Thiomalate / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced*
D000974:Antibodies, Antinuclear; D006052:Gold Sodium Thiomalate
Gold-induzierter systemischer Lupus erythematodes.