HLA-DR1 is a low responsiveness antigen in human kidney transplant recipients.
1. HLA-DR1 recipient phenotype showed increased overall and yearly graft survival. 2. Regraft and living-related HLA-DR1 recipients were found to have better graft survival. 3. Increased graft survival associated with the HLA-DR1 recipient phenotype was found in both CsA-and non-CsA-treated recipients. 4. Increased graft survival in HLA-DR1 recipient phenotypes was found within all matching groups. 5. HLA-DR1 phenotype was associated with low immunoresponsiveness. 6. HLA-DR1 donor kidneys when mismatched in the recipient were found to have lower graft survival.
Cicciarelli
J
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D003524:Cyclosporins / Q000627:therapeutic use; D005260:Female; D006085:Graft Survival; D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology* / Q000706:statistics & numerical data; D008297:Male; D010641:Phenotype
D003524:Cyclosporins; D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen