Triiodothyronine potentiation of the antidepressant effect of phenelzine.
Two patients with depression that was refractory to tricyclic antidepressant therapy alone and in combination with lithium or triiodothyronine (T3) were treated with the monoamine oxidase inhibitor phenelzine. In both cases, the addition of T3 potentiated the antidepressant response to phenelzine. These observations suggest that thyroid hormone potentiation may not be specific to one class of antidepressant drugs.
Joffe
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Department of Psychiatry, St. Michael's Hospital, Toronto, Ontario, Canada.
D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010624:Phenelzine / Q000494:pharmacology / Q000627:therapeutic use*; D014284:Triiodothyronine / Q000494:pharmacology* / Q000627:therapeutic use
D014284:Triiodothyronine; D010624:Phenelzine