Predicting the carcinogenicity of the aromatic amine derivatives tested in the second UKEMS Collaborative Study.
The carcinogenicity prediction and battery selection (CPBS) procedure was used to analyze the short-term in vitro and in vivo genotoxicity results obtained during the Second UKEMS Collaborative Study. In accordance with preliminary animal bioassay results, CPBS predicted correctly the carcinogenicity of benzidine, 4,4"-diaminoterphenyl and 4-dimethylaminoazobenzene. CPBS predicted the non-carcinogenicity of 4-cyanodimethylaniline, a chemical of as yet unknown carcinogenicity. Moreover, CPBS indicated that for the chemicals included in the UKEMS study, highly predictive as well as cost-effective batteries consisting of three short-term assays could be identified.
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Department of Environmental Health Sciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106.
Rosenkranz
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D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D001560:Benzidines / Q000494:pharmacology*; D002273:Carcinogens; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D013730:Terphenyl Compounds / Q000494:pharmacology*; D004124:p-Dimethylaminoazobenzene / Q000494:pharmacology*
D000814:Aniline Compounds; D001560:Benzidines; D002273:Carcinogens; D009153:Mutagens; D013730:Terphenyl Compounds; C029876:benzidine; C045996:4,4''-diaminoterphenyl; C042318:4-cyano-N,N-dimethylaniline; D004124:p-Dimethylaminoazobenzene