Sister chromatid exchanges induced by sarcolysine in human lymphocytes in vitro.
The effect of three concentrations of sarcolysine (0.5 micrograms/ml, 1 microgram/ml and 2 micrograms/ml) on the sister chromatid exchanges (SCE) was investigated in human lymphocytes in vitro. A dose related increase in SCEs frequencies was observed after sarcolysine administration and also a delayed development of cell cycle has been induced by the two last concentrations. The variation range of SCEs per cell was dose-dependent and it was considered to represent the acquired genetic instability induced by the drug.
Moraru
I
I
Georgian
L
L
Roman
I C
IC
Drăghicescu
T
T
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects*; D008558:Melphalan / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D008558:Melphalan