The structures of new antifungal antibiotics, benanomicins A and B.
Structures of new antifungal antibiotics, benanomicins A and B were determined to be N-[[5-[6-deoxy-3-O-(beta-D-xylopyranosyl)-beta-D-galactopyranosyloxy+  ++ ]-5, 6-dihydro-1,6,9,14-tetrahydroxy-11-methoxy-3-methyl-8,13-dioxobenzo++  + [a]naphthacen-2-yl]carbonyl]-D-alanine and N-[[5-[4-amino-4,6-dideoxy-3-O-(beta-D-xylopyranosyl)-beta-D- galactopyranosyloxy]-5,6-dihydro-1,6,9,14-tetrahydroxy-11-methoxy- 3-methyl-8,13-dioxobenzo[a]naphthacen-2-yl]carbonyl]-D-al ani ne, respectively, by spectral analyses and chemical degradation studies.
Gomi
S
S
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
Sezaki
M
M
Kondo
S
S
Hara
T
T
Naganawa
H
H
Takeuchi
T
T
D000107:Acetylation; D000143:Acids; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000032:analysis*; D000935:Antifungal Agents / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013302:Streptomyces / Q000032:analysis; D000095643:Pradimicins and Benanomicins
D000143:Acids; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; C056805:benanomicin A; D000095643:Pradimicins and Benanomicins; C056806:benanomicin B