title: [Intracellular microelectrode study of the electrophysiological effects of contrast media].
abstract: Intracellular microelectrodes were used to study the electrophysiological effects on action and resting potentials, refractory periods and conduction velocities of four contrast media administered either as 1/100 and 1/1000 solutions or as 20 mg bolus injections. The products studied were Telebrix, which has high osmolality (2100 mOsm/kg) and three other contrast media with lower osmolatity (700 mOsm/kg), including Hexabrix, which contains sodium, and Iopamidol and Iohexol which are sodium-free. The parameters measured were not modified by Hexabrix and Telebrix, whereas Omnipaque and Iopamiron induced varied and significant changes in these parameters, notably in concentrations of 1/100 and as bolus injections. It is suggested that the latter contrast media should be used in non-cardiovascular explorations and in patients without confirmed heart disease.
authors.affiliation: Laboratoire d'électrophysiologie, service de cardiologie, hôpital de la Salpêtrière, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Fillette
authors.forename: G
authors.initials: G
authors.lastname: Nassif
authors.forename: P
authors.initials: P
authors.lastname: Aouate
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000790:Angiocardiography / Q000379:methods; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology*; D004594:Electrophysiology; D006329:Heart Conduction System / Q000187:drug effects*; D007483:Iothalamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D008839:Microelectrodes; D009132:Muscles / Q000187:drug effects*; D011690:Purkinje Fibers / Q000187:drug effects*; D012756:Sheep
chemical_list: D003287:Contrast Media; D007483:Iothalamic Acid; C002587:ioxitalamic acid
vernacular_title: Etude par microélectrodes intracellulaires des effets électrophysiologiques des produits de contraste.