title: Intracavernous self-injection for impotence: a long-term therapeutic option? Experience in 78 patients.
abstract: A total of 78 patients 17 to 84 years old reported their experience via questionnaire with the papaverine-phentolamine injection technique for impotence. The mean number of injections used was 30.7. Penile induration occurred in 13 patients (16 per cent) and it was generally of limited extent. A higher incidence of induration was observed in those with vasculogenic impotence. Prolonged erection was reported by 23 per cent of the patients, 8 per cent of whom experienced erection for more than 12 hours. Priapism occurred exclusively in diabetic patients and patients with a neurological etiology of impotence. A total of 22 per cent of the patients reported moderate to severe pain with injection, 35 per cent indicated decreased quality of erection with time in response to the vasoactive agents and 28 per cent believed this therapy to be unsatisfactory. Among those who discontinued the injections 5 cited variability of erectile response (duration or quality) as the reason for discontinuation. A decrease in the effectiveness of the injections with time may be anticipated among some patients. For patients who face a penile implant without other options penile self-injection with vasoactive drugs is a reasonable alternative in that complications do not prevent successful prosthetic implantation.
authors.affiliation: Department of Surgery, University of Wisconsin Clinical Sciences Center, Madison.
authors.forename: F M
authors.initials: FM
authors.lastname: Girdley
authors.forename: R C
authors.initials: RC
authors.lastname: Bruskewitz
authors.forename: J
authors.initials: J
authors.lastname: Feyzi
authors.forename: P H
authors.initials: PH
authors.lastname: Graversen
authors.forename: T C
authors.initials: TC
authors.lastname: Gasser
mesh_terms: D003258:Consumer Behavior; D004338:Drug Combinations; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D010208:Papaverine / Q000008:administration & dosage* / Q000627:therapeutic use; D010410:Penile Erection / Q000187:drug effects*; D010411:Penile Induration / Q000139:chemically induced; D010646:Phentolamine / Q000008:administration & dosage* / Q000627:therapeutic use; D011317:Priapism / Q000139:chemically induced; D012646:Self Administration; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D010208:Papaverine; D010646:Phentolamine