Hymenolepis diminuta: lack of sulphate activation and sulphotransferase activity.
There is no evidence that Hymenolepis diminuta can carry out sulphoconjugation reactions. Neither whole worms nor worm extracts were able to sulphate 4-methylumbelliferone. No sulphotransferase activity could be demonstrated in H. diminuta using a variety of substrates, nor was H. diminuta capable of synthesising the sulphate donor 3'-phosphoadenosine-5'-phosphosulphate from ATP and inorganic sulphate. Possible alternative sources of active sulphate in this parasite are discussed.
Raines
P S
PS
Zoology Department, University College of Wales, Aberystwyth, Dyfed, United Kingdom.
Barrett
J
J
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D006160:Guanosine Triphosphate / Q000378:metabolism; D006923:Hymecromone / Q000378:metabolism; D006926:Hymenolepis / Q000201:enzymology / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D010724:Phosphoadenosine Phosphosulfate / Q000096:biosynthesis; D051381:Rats; D013431:Sulfates / Q000378:metabolism*; D013466:Sulfurtransferases / Q000378:metabolism*
D013431:Sulfates; D006923:Hymecromone; D010724:Phosphoadenosine Phosphosulfate; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D013466:Sulfurtransferases