title: [Synergistic activity of isepamicin and beta-lactam antibiotics against Pseudomonas aeruginosa in vitro and in vivo].
abstract: Synergistic activities of isepamicin (ISP) and a beta-lactam antibiotic such as piperacillin (PIPC) or cefotaxime (CTX) against Pseudomonas aeruginosa were demonstrated in vitro and in vivo. In vitro synergistic activity was observed when ISP was used together PIPC or CTX. The synergy observed in vitro was reproduced in vivo against experimental mouse infections, and a ISP-PIPC or a ISP-CTX combination showed significantly greater protective effects than individual antibiotics by themselves.
authors.affiliation: Research Laboratories, Toyo Jozo Co., Ltd.
authors.forename: Y
authors.initials: Y
authors.lastname: Shiritani
authors.forename: S
authors.initials: S
authors.lastname: Yamaji
authors.forename: A
authors.initials: A
authors.lastname: Aoki
authors.forename: M
authors.initials: M
authors.lastname: Saigusa
authors.forename: S
authors.initials: S
authors.lastname: Yokoiyama
authors.forename: S
authors.initials: S
authors.lastname: Gato
authors.forename: A
authors.initials: A
authors.lastname: Tsuji
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002439:Cefotaxime / Q000008:administration & dosage / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology / Q000627:therapeutic use; D005839:Gentamicins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010538:Peritonitis / Q000188:drug therapy; D010878:Piperacillin / Q000008:administration & dosage / Q000494:pharmacology; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development; D012141:Respiratory Tract Infections / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; C016927:isepamicin; D002439:Cefotaxime; D010878:Piperacillin