title: Renal dysfunction in dogs with pyometra.
abstract: Renal function and pathologic changes in 27 dogs with pyometra were studied. Evaluation included CBC; serum biochemical evaluation; urinalysis; urine and uterine bacteriologic culture; uterine morphologic features; and light, electron, and immunofluorescent microscopic evaluation of renal tissues. Measurements of 24-hour creatinine clearance, protein excretion, Na excretion, and urine volume were made in 12 dogs without azotemia. Of 27 dogs, 26% were azotemic and 89% had a urine sp gr less than 1.035. Glomerular filtration rate was reduced in 75% of 12 dogs without azotemia. None of these 12 dogs was proteinuric. Examination of renal biopsy specimens revealed a high prevalence of mild tubulointerstitial nephritis, but few specific glomerular lesions. Minimal immunofluorescence was detected within the mesangium in 18% of the dogs. Immunofluorescence was not associated with the interstitium or tubules. Urinary tract infection was detected in 22% of the dogs. Escherichia coli and Klebsiella were recovered from the uterus in 59 and 15% of the dogs, respectively. Low urine specific gravity values were obtained from dogs without azotemia and from dogs with uterine cultures considered negative for E coli and other gram-negative bacteria. The reduction in glomerular filtration rate was a functional abnormality not correlated with structural damage in the glomerulus.
authors.affiliation: Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104.
authors.forename: E A
authors.initials: EA
authors.lastname: Stone
authors.forename: M P
authors.initials: MP
authors.lastname: Littman
authors.forename: J L
authors.initials: JL
authors.lastname: Robertson
authors.forename: K C
authors.initials: KC
authors.lastname: Bovée
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D007674:Kidney Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D013492:Suppuration / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary; D014591:Uterine Diseases / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*