Effect of pharmacological agents on the activity of the circular and longitudinal smooth muscle layers of human fallopian tube ampullar segments.
The in vitro determination of the effects of some pharmacological agents on the outer diameter and axial tension of human Fallopian tube ampullar segments showed that some drugs may act on the circular and longitudinal smooth muscle layers relatively separately. PGF2 alpha elicited an excitatory response in both muscle layers while norepinephrine and isoproterenol decreased the activity. Oxytocin and indomethacin had relatively limited effects on the spontaneous motility of the ampullar segments. The calcium antagonist verapamil inhibited the spontaneous periodic activity.
László
A
A
Second Department of Obstetrics and Gynecology, Semmelweis University Medical School, Budapest, Hungary.
Nádasy
G L
GL
Monos
E
E
Zsolnai
B
B
D000328:Adult; D015237:Dinoprost; D005187:Fallopian Tubes / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D010121:Oxytocin / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D011460:Prostaglandins F; D010121:Oxytocin; D015237:Dinoprost; D014700:Verapamil; D007545:Isoproterenol; D009638:Norepinephrine; D007213:Indomethacin