[Effect of opioids on granulocyte adherence].
The influence of clinically relevant concentrations of fentanyl, alfentanil, morphine, pethidine, and buprenorphine on polymorphonuclear neutrophilic granulocyte (PMN) adherence was investigated in vitro by using nylon fibre columns. Since none of the drugs produced any significant (p less than 0.05) change of adherence, no evidence of opioid mediated increased risk of postoperative bacterial infection could be found.
Krumholz
W
W
Abteilung für Anaesthesiologie und operative Intensivmedizin, Justus-Liebig-Universität Giessen.
Weber
C
C
Käbisch
S
S
Hempelmann
G
G
D000328:Adult; D015760:Alfentanil; D002047:Buprenorphine / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005283:Fentanyl / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D008297:Male; D008614:Meperidine / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D009294:Narcotics / Q000633:toxicity*; D009504:Neutrophils / Q000187:drug effects*
D009294:Narcotics; D015760:Alfentanil; D002047:Buprenorphine; D009020:Morphine; D008614:Meperidine; D005283:Fentanyl
Der Einfluss von Opioiden auf die Granulozytenadhärenz.