Sex differences in the inhibition by ATD of testosterone-activated mounting behavior in guinea pigs.
Adult male and female guinea pigs from a genetically heterogeneous stock were gonadectomized and tested for mounting behavior before and during various treatments with testosterone cypionate (TC) alone or in combination with an aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD). ATD was implanted subdermally in Silastic capsules (either 1 or 2 in females; 2 or 3 in males). In females 2 capsules of ATD completely blocked the behavioral effects of TC, and 1 capsule was an effective blocker in 58% of the females. The blocking effect was reversed by injection of diethylstilbestrol. In males, there was no measurable effect of ATD on mounting activity even when 3 capsules were implanted. Moreover, the TC induction of higher components of male sexual behavior (intromission and ejaculation) was also not impaired by ATD. Results are interpreted as indicating that either the process of male sexual differentiation or the male genotype eliminates the requirement for aromatization in androgenic activation of sexual behavior.
Roy
M M
MM
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53715.
Goy
R W
RW
D000733:Androstatrienes / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004343:Drug Implants; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology
D000733:Androstatrienes; D004343:Drug Implants; C011658:androsta-1,4,6-triene-3,17-dione; D013739:Testosterone; C016131:testosterone 17 beta-cypionate