Chemoattractant lymphokines specific for the helper/inducer T-lymphocyte subset.
The cellular content of T-lymphocyte-rich inflammatory sites is dependent in part on the in situ elaboration of chemoattractant factors. We have previously described three T-lymphocyte-specific chemoattractant lymphokines; a chemokinetic factor, lymphocyte chemoattractant factor (LCF, MW 56,000), and two distinct lymphocyte migration inhibitory factors (LyMIF75K, MW 75,000; and LyMIF35K, MW 35,000). These factors are produced by human T cells in response to antigen, concanavalin A, or histamine stimulation. In this communication, we report that LCF and LyMIF35K are produced by OKT8+ (suppressor/cytotoxic) and OKT4+ (helper/inducer) lymphocytes, respectively, and are selectively chemoattractant for the OKT4+ lymphocyte subset. LyMIF75K is produced by OKT4+ cells and inhibits both OKT4+ and OKT8+ lymphocyte migration. Production of LCF and LyMIF35K by infiltrating lymphocyte subsets may be one mechanism whereby unactivated helper/inducer T lymphocytes are selectively recruited to sites of inflammation.
Berman
J S
JS
Cruikshank
W W
WW
Center
D M
DM
Theodore
A C
AC
Beer
D J
DJ
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000032:analysis; D019744:Chemokines, C; D002634:Chemotaxis, Leukocyte; D006801:Humans; D007961:Leukocyte Migration-Inhibitory Factors / Q000276:immunology*; D008222:Lymphokines / Q000276:immunology*; D012795:Sialoglycoproteins / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D019744:Chemokines, C; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines; D012795:Sialoglycoproteins; C092390:XCL1 protein, human; C018997:lymphotactin