Concentrations of androgens and C19-steroid sulphates in abdominal skin of healthy women and men.
Protein-binding assay and radioimmunoassay were used to determine the concentrations of free androgens and C19-steroid sulphates in suprapubic abdominal skin slices obtained from healthy women and men during appendectomy. It was found that the abdominal skin of the women contained DHA in the highest concentration, followed in decreasing order by And., delta 4-dione, delta 5-diol, Test. and DHT. The sequence was the same for the men, except that delta 4-dione preceded And. There was no significant difference in the concentrations of free androgens in abdominal skin of women and men; only the concentration of delta 4-dione was somewhat higher in the skin obtained from males (P less than 0.05). Of the C19-steroid sulphates, And.-S was found in the highest concentration in abdominal skin of females, followed in decreasing order by DHA-S, delta 5-diol-S and Test.-S. The corresponding decreasing sequence for the men was DHA-S, And.-S, delta 5-diol-S and Test.-S. The concentration of DHA-S was significantly higher (P less than 0.001) in men than in women; in the case of delta 5-diol-S, only a slight degree of significance could be observed (P less than 0.05).
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D000328:Adult; D000728:Androgens / Q000032:analysis*; D000735:Androstenedione / Q000032:analysis; D000738:Androsterone / Q000032:analysis; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000032:analysis; D019314:Dehydroepiandrosterone Sulfate; D013196:Dihydrotestosterone / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D012867:Skin / Q000032:analysis*; D013739:Testosterone / Q000031:analogs & derivatives / Q000032:analysis
D000728:Androgens; D013196:Dihydrotestosterone; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; C028627:testosterone-17-sulfate; D000738:Androsterone