title: Effects of treatment for isolated systolic hypertension on cognitive status and depression in the elderly.
abstract: The Systolic Hypertension in the Elderly Program (SHEP) was designed as a feasibility study and in part dealt with the effects of the treatment of isolated systolic hypertension on cognitive status and depression. Subjects were 60 years of age or older with a systolic blood pressure of 160 mmHg or greater and diastolic of less than 90 mmHg; free of several specified illnesses or chronic conditions. These volunteers were randomly assigned to treatment (n = 443) and placebo (n = 108) groups. The behavioral assessments at baseline and 1 year later were the SHORT-CARE instrument for depression, cognitive impairment, and disability and other tests of cognitive status (Digit Symbol Substitution and the Trail Making tests). Although the treatment regime was highly successful in controlling the hypertension, it did not have a significant impact on changes in cognitive function or level of depression; a behavioral benefit was not evident but the results are consistent with the view that an effective treatment regime for isolated systolic hypertension in the elderly can be behaviorally safe.
authors.affiliation: Columbia University Center for Geriatrics, New York, NY 10032.
authors.forename: B J
authors.initials: BJ
authors.lastname: Gurland
authors.forename: J
authors.initials: J
authors.lastname: Teresi
authors.forename: W M
authors.initials: WM
authors.lastname: Smith
authors.forename: D
authors.initials: D
authors.lastname: Black
authors.forename: G
authors.initials: G
authors.lastname: Hughes
authors.forename: S
authors.initials: S
authors.lastname: Edlavitch
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D003863:Depression / Q000517:prevention & control; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D013599:Systole
chemical_list: D000959:Antihypertensive Agents