[Phenotype of thymocyte populations in C57BL/Ka mice during the development of radiation-induced lymphomas].
In C57BL/Ka mice, irradiated with 4 weekly X-ray doses of 1,75 Gy, the phenotype of thymocyte populations was analyzed with monoclonal antibodies, lectins and flow cytometry. Four successive phases were defined: a) early after irradiation, a depletion of radiosensitive cortical thymocytes with a relative enrichment for radioresistant medullary type cells; b) a regeneration phase, during which thymocytes express the cortical immature phenotype; c) a third period, with a relative increase of a population with medullary phenotype; d) a late phase, during which thymocytes with the same phenotype as lymphoma cells accumulate.
Rongy
A M
AM
Greimers
R
R
Defresne
M P
MP
Boniver
J
J
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D037102:Lectins / Q000276:immunology; D008223:Lymphoma / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D010641:Phenotype; D011289:Preleukemia / Q000473:pathology; D013601:T-Lymphocytes / Q000528:radiation effects; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology*; D013953:Thymus Neoplasms / Q000473:pathology*; D013997:Time Factors
D000911:Antibodies, Monoclonal; D037102:Lectins
Phénotype des populations thymocytaires chez la souris C57BL/Ka au cours du développement des lymphomes radio-induits.