An evaluation of pelvic tissue concentrations after oral administration of enoxacin.
Twenty-seven patients received a single dose or three divided doses of enoxacin before total abdominal hysterectomy. Enoxacin levels were measured in biopsies from myometrium, fallopian tube and cervix as well as serum taken at the same time. The results showed good penetration of enoxacin into all three tissues.
Bates
S A
SA
Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, University of London, Hammersmith Hospital, UK.
Elder
M G
MG
D000284:Administration, Oral; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002584:Cervix Uteri / Q000378:metabolism*; D004334:Drug Administration Schedule; D015365:Enoxacin; D005187:Fallopian Tubes / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009215:Myometrium / Q000378:metabolism*; D009287:Naphthyridines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D000890:Anti-Infective Agents; D009287:Naphthyridines; D015365:Enoxacin