Stimulation of DNA synthesis but not of peroxisomal beta-oxidation by nafenopin in primary cultures of marmoset hepatocytes.
The effects of the peroxisome proliferator nafenopin upon primary cultures of marmoset hepatocytes have been investigated and compared to those on cultured rat hepatocytes. Nafenopin did not induce peroxisomal beta-oxidation or peroxisome proliferation but did induce replicative DNA synthesis. These findings demonstrate that peroxisome proliferation and mitogenicity are two independent properties of nafenopin and question the widely held view that primates are generally insensitive to the effects of peroxisome proliferators.
Bieri
F
F
Central Toxicology Unit, Ciba-Geigy Limited, Basel, Switzerland.
Stäubli
W
W
Waechter
F
F
Muakkassah-Kelly
S
S
Bentley
P
P
D000818:Animals; D002143:Callitrichinae / Q000378:metabolism*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D008099:Liver / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008830:Microbodies / Q000187:drug effects / Q000378:metabolism*; D009255:Nafenopin / Q000494:pharmacology* / Q000633:toxicity; D010084:Oxidation-Reduction / Q000187:drug effects; D011422:Propionates / Q000494:pharmacology*
D011422:Propionates; D009255:Nafenopin; D004247:DNA