title: [Therapeutic action of oral mesoglycan in the pharmacologic treatment of the varicose syndrome and its complications].
abstract: The comparative therapeutic efficacy of mesoglycan and a capillary protective drug derived from rutin was evaluated in a clinical study conducted on a group of patients with varicose syndrome and/or its complications. The clinical assessment of the results obtained was followed by a series of investigations aimed at identifying the action mechanism of the drugs under study. In the experimental model adopted, mesoglycan was found to be well tolerated and effective both in absolute terms and in comparison with the drug used for comparison. Apart from the clinical efficacy of mesoglycan, it was also shown to increase transcutaneous O2 perfusion and blood flow as evidenced by filtrability. On the basis of these results it is suggested that the clinical action and tolerability of mesoglycan make it a valuable aid in the arduous task of treating varicose syndrome and its complications.
authors.forename: V
authors.initials: V
authors.lastname: Petruzzellis
authors.forename: A
authors.initials: A
authors.lastname: Velon
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003490:Cyanosis / Q000209:etiology; D004341:Drug Evaluation; D004487:Edema / Q000209:etiology; D004890:Erythema / Q000209:etiology; D005260:Female; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D010292:Paresthesia / Q000209:etiology; D013577:Syndrome; D014648:Varicose Veins / Q000188:drug therapy*
chemical_list: D006025:Glycosaminoglycans; C040617:mesoglycan
vernacular_title: Sull'attività terapeutica del mesoglicano, somministrato per os, nel trattamento farmacologico della sindrome varicosa e delle sue complicanze.