L-phenylalanine mustard-dianhydrogalactitol and hyponatremia.
The incidence of hyponatremia in 34 patients following administration of high-dose L-phenylalanine mustard (L-PAM) and dianhydrogalactitol (DAG) was determined. Two consecutive daily levels of 133 mEq/l or less were observed in 12 patients. These episodes coincided with the advent of diarrhea about 10-12 days after drug administration. The hyponatremia was not due to the syndrome of inappropriate antidiuretic hormone secretion.
Helson
L
L
Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Sadof
M D
MD
Wernovsky
G
G
Gulati
S
S
D003937:Diagnosis, Differential; D003961:Dianhydrogalactitol / Q000009:adverse effects*; D003967:Diarrhea / Q000139:chemically induced / Q000150:complications*; D006801:Humans; D007010:Hyponatremia / Q000175:diagnosis / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D008558:Melphalan / Q000009:adverse effects*; D009423:Nervous System Neoplasms / Q000150:complications / Q000188:drug therapy; D009447:Neuroblastoma / Q000150:complications / Q000188:drug therapy; D011446:Prospective Studies
D003961:Dianhydrogalactitol; D008558:Melphalan