[AIDS encephalopathy in childhood or the late sequela of central nervous system leukemia?].
This case report is about an eleven year old boy with new developed symptoms of a cellular immundeficiency and a positive HIV-serology 33 months after a CNS-leukemia relapse. After 18 weeks a progredient neurological symptomatology is beginning with motor, cognitive and behavioral disturbances and a brain atrophy in the CT-scan. These cerebral manifestations are explainable as an encephalopathy both through HIV and after CNS-leukemia. A SSPE has been excluded. CT, EEG, Evoked Potentials do not show differential diagnostic pathognomonic findings regarding both diseases. The CSF findings hint at a persistent virus infection compatibel with the postulated slow virus pathogenesis of the AIDS-Encephalopathy. We conclude, that in this case an etiological diagnoses is only possible through histological brain examination and through demonstration of HIV or HIV-antigen in brain tissue respectively. AZT, which is reported to be effective against the cerebral AIDS-manifestations could not be applicated because of the existing pancytopenia.
Brunhuber
W
W
Kinderabteilung Landeskrankenhaus Steyr.
Emhofer
J
J
Ploier
R
R
D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology*; D001284:Atrophy; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology*; D002648:Child; D003937:Diagnosis, Differential; D004660:Encephalitis / Q000473:pathology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology*; D008297:Male; D019965:Neurocognitive Disorders / Q000473:pathology*; D009894:Opportunistic Infections / Q000473:pathology
AIDS-Enzephalopathie im Kindesalter oder Spätfolge einer ZNS-Leukämie?