Effects of antisecretory drugs on mucosal erosions induced by intragastric distension in rats: a comparative study.
The antiulcer effects of two classical antisecretory agents, cimetidine and pirenzepine, were compared with those of prostaglandin E2 and carbenoxolone sodium. The acid inhibitory action of drugs was not important in our study since the ulcer model employed consisted of perfusing the stomach continuously, at a high intraluminal pressure (120 mm H2O), with a simulated gastric juice (0.1 M HCl plus 600 mg pepsin/l). Cimetidine and pirenzepine failed to inhibit gastric erosions, whereas prostaglandin E2 and carbenoxolone greatly reduced the severity of the mucosal lesions. Long-term treatment with cimetidine did not prevent gastric damage. These findings indicate that pure antisecretory agents do not directly increase the capacity of the mucosa to resist damage.
Martí-Cabrera
M
M
Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain.
Esplugues
J V
JV
Martí-Bonmati
L
L
Sarria
B
B
Vento
A
A
Martí-Bonmati
E
E
Gil
L
L
Esplugues
J
J
D000818:Animals; D002229:Carbenoxolone / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D015232:Dinoprostone; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010890:Pirenzepine / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000503:physiopathology
D011458:Prostaglandins E; D010890:Pirenzepine; D002927:Cimetidine; D015232:Dinoprostone; D002229:Carbenoxolone