title: DNA haplotypes and frameworks associated with the beta-globin gene in the Kachari population of Assam (India).
abstract: DNA haplotypes and frameworks associated with the beta-globin gene were determined in a Tibeto-Burman group, the Kachari, from Upper Assam, India, using restriction analysis at eight restriction sites. Of the total of 59 subjects, 26 were homozygous for HBB*A and 33 homozygous for HBB*E. Complete haplotype determination in 33 subjects revealed a conspicuous difference in haplotype distribution between HBB*A- and HBB*E-bearing chromosomes. The Southeast Asian HBB*E-associated haplotype -+- +- (27-2 in the present terminology) predominated on HBB*E chromosomes. The previously established beta-globin-associated frameworks 1, 2 and 3 were evenly distributed among the HBB*A chromosomes, whereas all HBB*E chromosomes had framework 2. These findings favor a common origin of the HBB*E gene in Southeast Asia and Assam.
authors.affiliation: Department of Human Genetics, Medizinische Hochschule Hannover, FRG.
authors.forename: J
authors.initials: J
authors.lastname: Hundrieser
authors.forename: R
authors.initials: R
authors.lastname: Deka
authors.forename: B C
authors.initials: BC
authors.lastname: Gogoi
authors.forename: T
authors.initials: T
authors.lastname: Papp
authors.forename: G
authors.initials: G
authors.lastname: Flatz
mesh_terms: D000328:Adult; D004247:DNA / Q000235:genetics*; D005914:Globins / Q000235:genetics*; D006239:Haplotypes; D006446:Hemoglobin E / Q000235:genetics; D006801:Humans; D007194:India; D005810:Multigene Family; D015183:Restriction Mapping
chemical_list: D005914:Globins; D004247:DNA; D006446:Hemoglobin E