Interconnection of demyelination processes and inflammation in the dynamics of experimental allergic encephalomyelitis.
Using a new method for the simultaneous demonstration of myelin breakdown products and cell elements in the demyelinated nervous tissue, a number of previously unknown regularities were revealed concerning interconnection between demyelination processes and inflammation in the dynamics of experimental allergic encephalomyelitis (EAE). Alterations in osmophilia and in size of myelin breakdown products in the demyelination foci are demonstrated to be the most essential in the EAE pathomorphology, a certain type of cellular reaction corresponding to each stage of periaxonal changes. A close relationship was found between demyelination processes and inflammation which determines the structure of the demyelination foci at various stages of the disease.
Khizhnyak
M G
MG
Institute for Experimental Medicine, USSR Academy of Medical Sciences, Leningrad.
Zhitnukhin
Y L
YL
Konovalov
G V
GV
Semenov
S P
SP
D000818:Animals; D001921:Brain / Q000473:pathology; D003711:Demyelinating Diseases / Q000473:pathology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000473:pathology*; D006168:Guinea Pigs; D006651:Histocytochemistry; D009186:Myelin Sheath / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology