The genotoxicity of a variety of aniline derivatives in a DNA repair test with primary cultured rat hepatocytes.
The genotoxicity of a variety of aniline derivatives was examined by a DNA repair test with rat hepatocytes. Out of 37 aniline derivatives, 6 chemicals, i.e., 2,4,6-trimethylaniline (mesidine), 2,4-xylidine, 3,5-diaminobenzoic acid, 3,4-diaminochlorobenzene, 2-chloro-4-methylaniline and 4-chloro-N-methylaniline, elicited positive DNA repair responses. The results are in agreement with the bacterial mutagenicities with or without norharman of these compounds. Positive compounds of unknown carcinogenicity in the present assay, i.e., 3,5-diaminobenzoic acid, 2-chloro-4-methylaniline and 4-chloro-N-methylaniline are suspected of being potentially carcinogenic.
Yoshimi
N
N
Department of Pathology, Gifu University School of Medicine, Japan.
Sugie
S
S
Iwata
H
H
Niwa
K
K
Mori
H
H
Hashida
C
C
Shimizu
H
H
D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D004260:DNA Repair / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D051381:Rats; D013329:Structure-Activity Relationship
D000814:Aniline Compounds; D009153:Mutagens