title: Comparative study of the bronchodilating effects of (-)- and (+)-oxyphenonium bromide.
abstract: 1. Racemic oxyphenonium bromide, its enantiomers and placebo were inhaled by eight adult patients with chronic airflow obstruction, in a four-way double-blind cross-over study. 2. Forced expiratory volume in one second (FEV1) and slow inspiratory vital capacity (VC) were measured during the first 6 h after inhalation. 3. (+)-Oxyphenonium was found to be the active enantiomer (eutomer), providing better bronchodilation than (+/-)-oxyphenonium. 4. The distomer, (-)-oxyphenonium, showed only a slight effect on FEV1 and VC as compared with placebo.
authors.affiliation: Department of Analytical Chemistry and Toxicology, Groningen, The Netherlands.
authors.forename: K G
authors.initials: KG
authors.lastname: Feitsma
authors.forename: D S
authors.initials: DS
authors.lastname: Postma
authors.forename: G H
authors.initials: GH
authors.lastname: Koëter
authors.forename: G D
authors.initials: GD
authors.lastname: Nossent
authors.forename: B F
authors.initials: BF
authors.lastname: Brenth
authors.forename: R A
authors.initials: RA
authors.lastname: de Zeeuw
mesh_terms: D000328:Adult; D001993:Bronchodilator Agents; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010115:Oxyphenonium / Q000494:pharmacology* / Q000627:therapeutic use; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D011897:Random Allocation; D013237:Stereoisomerism; D013997:Time Factors
chemical_list: D001993:Bronchodilator Agents; D000644:Quaternary Ammonium Compounds; D010115:Oxyphenonium