[Effect of isosorbide dinitrate on the lower esophageal sphincter pressure in patients with Chagas' disease].
The effect of 5 mg of sublingual isosorbide dinitrate on the lower esophageal sphincter pressure of 28 chagasic patients with esophageal involvement, was studied by continuous perfusion manometry. The pressure was measured at 5 minute intervals for 60 minutes after drug administration. Isosorbide dinitrate reduced sphincter pressure from 5 to 60 minutes (p less than 0.01). Only two patients hadn't sphincter pressure reduced lower than 50% of initial value at 20 minutes after drug administration. These results indicate that isosorbide dinitrate may be useful to reduce lower esophageal sphincter pressure in chagasic megaesophagus.
Dantas
R O
RO
Departamento de Clinica Médica, Faculdade de Medicina, Universidade de São Paulo, Ribeirão Preto.
Rezende Filho
J
J
de Oliveira
R B
RB
de Godoy
R A
RA
D000328:Adult; D000368:Aged; D014355:Chagas Disease / Q000503:physiopathology*; D004943:Esophagogastric Junction / Q000187:drug effects*; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000494:pharmacology*; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011312:Pressure
D007548:Isosorbide Dinitrate
Efeito do dinitrato de isosorbitol na pressão do esfíncter inferior do esôfago de pacientes com doença de Chagas.