title: Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.
abstract: 3,5-Dimethylbenzo[1,2-c:5,4-c']dipyrazoles, optionally substituted in the 1-, 7-, and 8-positions, were synthesized from resorcinols. These compounds display affinity for adenosine A1 (rat brain) and A2 (human platelet) receptors. In addition, these compounds reverse contractions of guinea pig tracheal cylindrical segments induced by potassium chloride, histamine, acetylcholine, and 5-hydroxytryptamine, as well as reverse bronchospasm induced by aerosolized histamine in the conscious guinea pig.
authors.affiliation: Merrell Dow Research Institute, Cincinnati, Ohio 45215.
authors.forename: N P
authors.initials: NP
authors.lastname: Peet
authors.forename: G A
authors.initials: GA
authors.lastname: Dickerson
authors.forename: A H
authors.initials: AH
authors.lastname: Abdallah
authors.forename: J W
authors.initials: JW
authors.lastname: Daly
authors.forename: D
authors.initials: D
authors.lastname: Ukena
mesh_terms: D000241:Adenosine / Q000037:antagonists & inhibitors*; D000818:Animals; D001980:Bronchi / Q000187:drug effects; D006168:Guinea Pigs; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011983:Receptors, Purinergic / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D011720:Pyrazoles; D011983:Receptors, Purinergic; D000241:Adenosine