title: The use of antiserotonergic agents for the treatment of acute hemorrhagic shock of cats.
abstract: In cats anesthetized with pentobarbitone sodium the effect of two types of antiserotonergic agents on cardiovascular recuperation after acute hemorrhage was examined. Methysergide, a competitive inhibitor for 5-HT receptors and p-chlorophenylalanine (PCPA), an inhibitor of tryptophan-5-hydroxylase, improved blood pressure recovery after bleeding. After extensive hemorrhage (40 ml/kg blood), treatment with methysergide improved survival. It is proposed that serotonin participates in the depressor response and survival of acute hypovolemic hypotension.
authors.forename: R
authors.initials: R
authors.lastname: Elam
authors.forename: F
authors.initials: F
authors.lastname: Bergmann
authors.forename: G
authors.initials: G
authors.lastname: Feuerstein
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002415:Cats; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D012702:Serotonin Antagonists; D010134:Fenclonine; D008784:Methysergide