The plasma inhibitors of plasminogen activator, studied by a zymographic technique.
A zymographic technique for the detection of inhibitors of plasminogen activators has been applied to the analysis of plasma. Two inhibitors have been demonstrated; one inhibited plasmin with consequent apparent inhibition of urokinase and tissue-type plasminogen activator activity; it was identified as alpha 2-antiplasmin. The second inhibitor, as yet unidentified, had a molecular weight of about 40K. It inhibited urokinase and tissue-type plasminogen activator but had no effect on plasmin.
Booth
N A
NA
Anderson
J A
JA
Bennett
B
B
D001769:Blood; D004591:Electrophoresis, Polyacrylamide Gel; D005341:Fibrinolysin / Q000037:antagonists & inhibitors; D006801:Humans; D008722:Methods; D008970:Molecular Weight; D010960:Plasminogen Activators / Q000037:antagonists & inhibitors*; D015849:Plasminogen Inactivators; D014568:Urokinase-Type Plasminogen Activator / Q000037:antagonists & inhibitors
D015849:Plasminogen Inactivators; D010960:Plasminogen Activators; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator