title: Postradiation multicentric osteosarcoma.
abstract: The oncogenic effects of radiation are well-established. Osteosarcomas and fibrosarcomas are the two most common histologic types of secondary sarcoma. In this article a case of postradiation osteosarcoma is presented in which four discrete foci of sarcomatous transformation have occurred in the tibia and fibula after irradiation for a rhabdomyosarcoma of the calf 8 years earlier. A review of the literature reveals no similar case. Although synchronous, multifocal osteosarcoma without prior radiation has been described, this case differs in clinical, radiographic, and pathologic features; it best fits the description of postradiation multicentric osteosarcoma.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston 02114.
authors.forename: C
authors.initials: C
authors.lastname: Tillotson
authors.forename: A
authors.initials: A
authors.lastname: Rosenberg
authors.forename: M
authors.initials: M
authors.lastname: Gebhardt
authors.forename: D I
authors.initials: DI
authors.lastname: Rosenthal
mesh_terms: D001859:Bone Neoplasms / Q000209:etiology* / Q000473:pathology / Q000532:radiotherapy; D002648:Child; D005260:Female; D005360:Fibula; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D012516:Osteosarcoma / Q000209:etiology* / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects*; D012208:Rhabdomyosarcoma / Q000532:radiotherapy; D013977:Tibia