Response variability of ethanol-induced locomotor activation in mice.
Mice from a randomly bred strain were divided into two groups according to their locomotor responses to ethanol (0.8-3.0 g/kg): in two thirds of the tested animals ethanol increased locomotor activity (ethanol activated-EA), whereas in the remaining one third it did not (ethanol non-activated-ENA). Both groups did not differ in their locomotor activity after saline administration. Furthermore, EA and ENA mice presented a similar increase in locomotor activity after challenge with 1.0 and 2.0 mg/kg d-amphetamine. Chronic exposure to ethanol increased the ethanol-induced locomotor activation in both EA and ENA groups. The possibility that the lack of responsiveness of ENA mice to ethanol's acute activating effect could be due to a higher sensitivity to the depressant effect of ethanol is discussed.
Masur
J
J
Departamento de Psicobiologia, Escola Paulista de Medicina, São Paulo, Brazil.
dos Santos
H M
HM
D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*
D000431:Ethanol; D003913:Dextroamphetamine