[Comparative study of preparations of sodium and magnesium valproate (VPA) in treatment of patients with epileptic seizures].
A double blind cross over trial of Sodium Valproate (Na VPA) vs Magnesium Valproate (Mg VPA) was performed in 122 patients affected by focal or generalized epilepsies. Only modest differences resulted from the comparison between the two drugs: retention was 8% superior in patients treated with Mg VPA, the number of critic episodes and the quantification of interictal events was significantly lower in patients affected by focal epilepsy treated with Mg VPA. The incidence of side effects was the same for the two drugs.
Onofrj
M
M
Clinica Neurologica, Università Statale G. D'Annunzio, Chieti.
Colangelo
U
U
Malatesta
G
G
Di Giovanni
M
M
D000293:Adolescent; D000328:Adult; D002648:Child; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004341:Drug Evaluation; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D011897:Random Allocation; D014635:Valproic Acid / Q000627:therapeutic use*
D014635:Valproic Acid
Studio comparativo di preparazioni di valproato (VPA) di sodio e di magnesio nel trattamento di pazienti affetti da crisi epilettiche.