Acute promyelocytic leukemia presenting as sudden blindness and sinus vein thrombosis.
An 11-year-old boy was hospitalized with sudden blindness and sagittal sinus vein thrombosis, which were the presenting signs of acute promyelocytic leukemia (APL). The association of disseminated intravascular clotting (DIC) with APL is well-known, and DIC usually affects the smaller blood vessels. The obliteration of a large blood vessel, as in our case, is an uncommon manifestation of DIC. This presentation of acute childhood leukemia is unusual and, to the best of our knowledge, has not been previously reported.
Hazani
A
A
Department of Hematology, Rambam Medical Center, Haifa, Israel.
Weidenfeld
Y
Y
Tatarsky
I
I
Bental
E
E
D001766:Blindness / Q000097:blood / Q000175:diagnosis*; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000175:diagnosis*; D008297:Male; D013924:Thrombophlebitis / Q000097:blood / Q000175:diagnosis*