Effects of dietary linoleic acid enrichment on induction of immune complex nephritis in mice.
In pharmacologic doses E series prostaglandins attenuate the development of immune complex nephritis. We studied the effect of the dietary prostaglandin precursor linoleic acid on murine apoferritin-induced immune complex glomerulonephritis. High, normal, or low linoleic acid diets were fed to mice for 4 weeks prior to and during the intraperitoneal apoferritin administration. A high linoleic acid diet feeding was associated with less proteinuria, less renal histologic damage, and prevented a rise in serum creatinine. We conclude that linoleic acid has a protective effect on the development of murine apoferritin-induced immune complex nephritis.
Kher
V
V
Barcelli
U
U
Weiss
M
M
Pollak
V E
VE
D000818:Animals; D001052:Apoferritins; D004032:Diet; D005921:Glomerulonephritis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D007105:Immune Complex Diseases / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D007678:Kidney Glomerulus / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D011458:Prostaglandins E / Q000378:metabolism; D011507:Proteinuria / Q000517:prevention & control
D008041:Linoleic Acids; D011458:Prostaglandins E; D001052:Apoferritins; D019787:Linoleic Acid