Deterioration of male sexual behavior in rats by the new prolactin-secreting tumor 7315b.
The effects of hyperprolactinemia on male copulatory behavior in adult male and female rats were studied. Hyperprolactinemia was induced by the transplantable purely prolactin-secreting tumor 7315b. Male rats were castrated and received testosterone-filled capsules of different sizes which induced normal and subnormal testosterone levels. After sexual training the rats of the experimental groups were inoculated with tumor 7315b. Three weeks after tumor-inoculation high prolactin levels (2000-30000 ng/ml) were found. During this hyperprolactinemia ejaculation latency increased significantly, while the mount frequency and intromission frequency remained unchanged. Only 9 out of 22 rats ejaculated 19 days after inoculation. Moreover, it appeared that the inhibitory effect of the tumor was as strong in the presence of normal (2.33 +/- 0.07 ng/ml) as in the presence of low (0.35 +/- 0.01 ng/ml) testosterone levels. The inhibitory effect of tumor 7315b on copulatory behavior was not influenced by adrenalectomy. In gonadectomized female rats bearing testosterone-filled capsules tumor 7315b induced prolactin levels of about 2000 ng/ml and an almost complete cessation of mounts and intromission patterns 4 weeks after tumor-inoculation. It was concluded that tumor 7315b causes a strong inhibitory effect on male copulatory behavior in male and female rats and that this effect is not influenced by the presence of normal or low testosterone levels or removal of the adrenals, suggesting a direct effect of prolactin on brain functions.
Kooy
A
A
Department of Endocrinology, Growth and Reproduction, Faculty of Medicine, Erasmus University, Rotterdam.
Weber
R F
RF
Ooms
M P
MP
Vreeburg
J T
JT
D000818:Animals; D003307:Copulation / Q000502:physiology; D004542:Ejaculation; D005260:Female; D006729:Hormones, Ectopic / Q000097:blood*; D008297:Male; D009368:Neoplasm Transplantation; D011388:Prolactin / Q000097:blood*; D015175:Prolactinoma / Q000378:metabolism*; D051381:Rats; D011915:Rats, Inbred BUF; D012726:Sexual Behavior, Animal / Q000502:physiology*
D006729:Hormones, Ectopic; D011388:Prolactin