Diphenylhydantoin-induced hypersensitivity reaction with interstitial nephritis.
A 10-year-old black girl had an episode of diphenylhydantoin(DPH)-induced exfoliative dermatitis, lymphadenopathy, hepatitis, peripheral eosinophilia, and transient renal failure. The findings of specific lymphocyte sensitization of DPH, a clinically typical delayed hypersensitivity reaction, multinucleated histiocytes in the renal interstitium, and negative renal immunofluorescence studies for immune reactants indicate that the child's renal injury was at least partially cell-mediated.
Matson
J R
JR
Krous
H F
HF
Blackstock
R
R
D001324:Autoantigens / Q000032:analysis; D002648:Child; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000276:immunology / Q000473:pathology*; D005260:Female; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D010672:Phenytoin / Q000009:adverse effects*
D001324:Autoantigens; D010672:Phenytoin