[Azoles. 18. Sulfonylindazole derivatives].
The nucleophilic substitution of hydrogen to synthesize the sulphonyl indazole derivatives 9-16 is described. The structures of the substitution products are discussed using H-NMR spectra. Chemical structural proof was given by steric hindrance observed in the process of chorination of 9-16. The compounds 3, 4, 7, 8, 14, and 16 are studied to find an inhibition on phospholipase-A2 and lipoxygenase-I.
Dudzińska-Usarewicz
J
J
Lehrstuhl für Organische Chemie der Karol Marcinkowski Medizinischen Akademie, Poznań, VR Polen.
Wrzeciono
U
U
Frankiewicz
A
A
Linkowska
E
E
Köhler
T
T
Nuhn
P
P
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D001393:Azoles / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007191:Indazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors; D009682:Magnetic Resonance Spectroscopy; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D054467:Phospholipases A2; D011720:Pyrazoles / Q000138:chemical synthesis*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001393:Azoles; D007191:Indazoles; D016859:Lipoxygenase Inhibitors; D011720:Pyrazoles; D010741:Phospholipases A; D054467:Phospholipases A2
Azole. 18. Mitteilung: Sulfonylindazolderivate.