Surgical treatment for osteosarcoma.
Fifty-three patients who had a high-grade osteosarcoma had either a limb-salvage resection or an amputation. They all received adjuvant therapy that consisted of administration of Adriamycin (doxorubicin) and whole-lung irradiation. At the time of follow-up, the surgical margin was assessed by examination of the surgical specimen. Each patient was followed for at least three years or until death. The data suggested that a wide surgical margin is adequate to control a primary osteosarcoma. When a wide surgical margin can be used and a functional limb can be salvaged, an amputation probably is not required.
Springfield
D S
DS
Department of Orthopaedics, University of Florida, Gainesville 32610.
Schmidt
R
R
Graham-Pole
J
J
Marcus
R B
RB
Spanier
S S
SS
Enneking
W F
WF
D000293:Adolescent; D000328:Adult; D000671:Amputation, Surgical; D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D001932:Brain Neoplasms / Q000556:secondary; D002648:Child; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012516:Osteosarcoma / Q000473:pathology / Q000556:secondary / Q000601:surgery*
D004317:Doxorubicin