Bone and soft connective tissue response to porous acrylic implants. A histokinetic study.
The ingrowth kinetics of soft and hard tissues near pre-polymerized and in-situ-polymerized large pore, in-situ-polymerized small pore and solid acrylic implants were investigated. Empty cavities served as controls. Aqueous sodium carboxymethyl cellulose (CMC) gel was dispersed in bone cement to create interconnected porosity. After periods of insertion from 2 days up to 26 weeks in frontal and parietal bones in pigs, tissue blocks containing implants were embedded in JB4 and studied by light microscopy. After the disappearance of the CMC-gel, at first only cells invaded the large pore implants but necrotized when at some distance from the implant surface. Later, when blood vessels grew into the pores, accompanying vital fibrous connective tissue was observed. Finally, all pores were filled with connective tissue. Surrounding bone was first resorbed, starting at day 7, creating a soft tissue interface. A zone of bone deposition, starting deep in the remaining bone at day 2, moved towards the implant, thereby bridging the soft tissue interface. At 6 weeks bone grew into the pores, thus anchoring the implant. Continuing deposition of bone around the implant provided a so-called lamina dura effect with all implants. Qualitatively similar tissue kinetics were observed around solid and pre-polymerized large pore implants, evidently in the case of solid implants without tissue ingrowth. Into the small pore implants only superficial soft or hard tissue ingrowth was seen because of the too small interconnections.
van Mullem
P J
PJ
Dept. of Oral Histology, Dental School, University of Nijmegen, The Netherlands.
de Wijn
J R
JR
D000818:Animals; D001672:Biocompatible Materials; D001843:Bone Cements / Q000494:pharmacology*; D001862:Bone Resorption / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects*; D002266:Carboxymethylcellulose Sodium; D003238:Connective Tissue / Q000187:drug effects*; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000494:pharmacology*; D011102:Polyhydroxyethyl Methacrylate / Q000494:pharmacology*; D011108:Polymers; D011109:Polymethacrylic Acids / Q000494:pharmacology*; D019736:Prostheses and Implants; D013552:Swine
D001672:Biocompatible Materials; D001843:Bone Cements; D008768:Methylmethacrylates; D011108:Polymers; D011109:Polymethacrylic Acids; D020366:Methylmethacrylate; D011102:Polyhydroxyethyl Methacrylate; D002266:Carboxymethylcellulose Sodium