title: Natural resistance against lymphoma grafts conveyed by H-2Dd transgene to C57BL mice.
abstract: The H-2Dd transgenic strain D8 on C57BL background was more resistant to subcutaneous challenge of RBL-5 lymphoma cells than B6 controls. The direct role of the H-2Dd antigen was investigated by the use of (D8 x B6)F1 crosses and (D8 B6) x B6 backcrosses. The latter showed cosegregation with regard to Dd antigen expression and lymphoma resistance, both of which were inherited in a pattern consistent with control by a single dominant gene. The rejection potential in (D8 x B6)F1 mice appeared as strong as that seen in crosses between B6 and MHC congenic mice (on B10 background) carrying H-2Dd. The lymphoma resistance could be abrogated by treatment with anti-asialo GM1 antiserum or anti-NK 1.1 mAb, indicating a role for NK cells.
authors.affiliation: Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Höglund
authors.forename: H G
authors.initials: HG
authors.lastname: Ljunggren
authors.forename: C
authors.initials: C
authors.lastname: Ohlén
authors.forename: L
authors.initials: L
authors.lastname: Ahrlund-Richter
authors.forename: G
authors.initials: G
authors.lastname: Scangos
authors.forename: C
authors.initials: C
authors.lastname: Bieberich
authors.forename: G
authors.initials: G
authors.lastname: Jay
authors.forename: G
authors.initials: G
authors.lastname: Klein
authors.forename: K
authors.initials: K
authors.lastname: Kärre
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006183:H-2 Antigens / Q000235:genetics*; D064532:Histocompatibility Antigen H-2D; D007694:Killer Cells, Natural / Q000276:immunology; D008223:Lymphoma / Q000276:immunology*; D008285:Major Histocompatibility Complex; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009368:Neoplasm Transplantation
chemical_list: D006183:H-2 Antigens; D064532:Histocompatibility Antigen H-2D