High frequency of Mlsa-reactivity among Ab-restricted, H-Y-specific T cell clones.
A high frequency (80%) of Ab-restricted, H-Y-specific T cell clones, but not of Ab-restricted LDH-B-specific T cell clones, was found to be Mlsa-reactive. This reactivity could be inhibited by class II (A and E)-specific antibodies, and required an E-positive stimulator cell. The proliferation was also blocked by T cell receptor-specific and by CD4-specific antibodies. Possible interpretations of these findings are discussed.
Frangoulis
B
B
Max-Planck-Institut für Biologie, Tübingen, FRG.
Klein
J
J
D000818:Animals; D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology*; D002999:Clone Cells / Q000276:immunology; D006182:H-Y Antigen / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D016747:Minor Lymphocyte Stimulatory Antigens; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D006182:H-Y Antigen; D000949:Histocompatibility Antigens Class II; D016747:Minor Lymphocyte Stimulatory Antigens; D011948:Receptors, Antigen, T-Cell