title: Childhood cancer in siblings.
abstract: The medical records of 973 previously untreated patients diagnosed between January 1960 and December 31, 1978 with childhood cancer were reviewed. Siblings in 13 families were diagnosed with cancer 9/12 to 15 years after the diagnosis of cancer in the index sibling. Previously unreported association of acute lymphoblastic leukemia with Hodgkin's disease, neuroblastoma with malignant hemangiopericytoma, non-Hodgkin's lymphoma with malignant melanoma, Wilms' tumor with non-Hodgkin's lymphoma, Hodgkin's disease with malignant teratoma of the testis and craniopharyngioma with acute myeloblastic leukemia were identified. Two families appeared to transmit a predisposition to childhood tumors. The data from these families extend previous observations regarding multiple cases of cancer in sibships.
authors.affiliation: Department of Pediatrics, Roswell Park Memorial Institute, Buffalo, New York 14263.
authors.forename: D M
authors.initials: DM
authors.lastname: Green
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005190:Family; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D009518:New York / Q000453:epidemiology; D010375:Pedigree