The status of sulphated isomers of glycosaminoglycans in fluorosed human teeth.
Fluorosed human teeth have lower concentrations of glycosaminoglycan (GAG) disaccharides and an increased dermatan sulphate content. Teeth from subjects with a high fluoride intake have a higher ratio of 4-sulphated to 6-sulphated GAGs. Increased dermatan sulphate may be an important factor in the clinical manifestations of fluorosis.
Susheela
A K
AK
Department of Anatomy, All India Institute of Medical Sciences, New Delhi.
Sharma
K
K
Rajan
B P
BP
Gnanasundaram
N
N
D000293:Adolescent; D000328:Adult; D002648:Child; D002809:Chondroitin Sulfates / Q000032:analysis; D003871:Dermatan Sulfate / Q000032:analysis; D009050:Fluorosis, Dental / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000032:analysis*; D006801:Humans; D007536:Isomerism
D006025:Glycosaminoglycans; D003871:Dermatan Sulfate; D002809:Chondroitin Sulfates