Preventive treatment of rabbit coccidiosis with alpha-difluoromethylornithine.
The effect of alpha-difluoromethylornithine (DFMO) administered in drinking water (0.2 and 0.5%) against liver and intestinal coccidioses in experimentally infected rabbits was studied. Zootechnical and clinical parameters were used to assess the efficacy of the compound. In both coccidioses the lower dose did not show any important effect. The higher dosage (0.5%) however, reduced the lesions induced by coccidia to an important extent. The animals infected and treated with 0.5% DFMO showed similar weight gain, food intake and relative liver weight figures to the non-infected controls. Serum transaminase levels in the rabbits infected with Eimeria stiedai and treated with 0.5% DFMO were close to those of the non-infected animals. Infected rabbits treated with this dosage also showed reductions (over 80%) in faecal oocyst output.
San Martín-Núñez
B V
BV
Departamento de Farmacología y Toxicología, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain.
Ordóñez-Escudero
D
D
Alunda
J M
JM
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D003048:Coccidiosis / Q000517:prevention & control / Q000662:veterinary*; D004435:Eating; D000518:Eflornithine / Q000627:therapeutic use*; D005243:Feces / Q000469:parasitology; D007411:Intestinal Diseases, Parasitic / Q000517:prevention & control / Q000662:veterinary*; D008099:Liver / Q000473:pathology; D008109:Liver Diseases, Parasitic / Q000517:prevention & control / Q000662:veterinary*; D008297:Male; D009929:Organ Size; D011817:Rabbits / Q000469:parasitology*; D015430:Weight Gain
D001219:Aspartate Aminotransferases; D000518:Eflornithine