title: [Molecular and cellular mechanisms of compensation for respiratory failure in nonspecific lung diseases].
abstract: Some molecular and cellular mechanisms of compensation for respiratory failure (RF) were examined in 90 patients with nonspecific pulmonary diseases. In acute RF, the content of 2,3-DPH in red blood cells was increased. As RF progressed, the compensatory-adaptation reaction became less marked. In chronic RF, the 2,3-DPH content in red blood cells did not differ from the control values. The disease was characterized by cholesterol a and sphingomyelin accumulation, a reduction in red blood cell ATPase activity, and an increase in microviscosity of red blood cell membranes. Decelerated utilization of ATPases in red blood cells is of a role in the genesis of a rise of the 2,3-DPH content in acute RF.
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Landyshev
authors.forename: E A
authors.initials: EA
authors.lastname: Borodin
mesh_terms: D019794:2,3-Diphosphoglycerate; D000222:Adaptation, Physiological; D000251:Adenosine Triphosphatases / Q000097:blood; D001809:Blood Viscosity; D004163:Diphosphoglyceric Acids / Q000097:blood; D004910:Erythrocyte Membrane / Q000502:physiology; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007700:Kinetics; D008055:Lipids / Q000097:blood; D008171:Lung Diseases / Q000150:complications / Q000503:physiopathology*; D008564:Membrane Potentials; D012131:Respiratory Insufficiency / Q000503:physiopathology*
chemical_list: D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D008055:Lipids; D019794:2,3-Diphosphoglycerate; D000251:Adenosine Triphosphatases
vernacular_title: Molekuliarno-kletochnye mekhanizmy kompensatsii dykhatel'noĭ nedostatochnosti pri nespetsificheskikh zabolevaniiakh legkikh.