title: Relationship between Campylobacter pylori and gastritis in healthy humans after administration of placebo or indomethacin.
abstract: Endoscopic and microscopic appearances of antral and fundic mucosa were correlated with the presence or absence of Campylobacter pylori--and with plasma immunoglobulin G antibodies to that organism--in 23 healthy volunteers, 12 of whom had received indomethacin and 11 of whom had received no medication. Antral C. pylori, found in 9 of 23 biopsy specimens (3 of 11 controls, 6 of 12 indomethacin-treated patients; not significantly different), correlated strongly with histologic evidence of active superficial antral gastritis (p less than 0.005), but not with the endoscopic appearance of the antrum. In contrast to the antrum, fundic C. pylori, found in 14 of 23 biopsy specimens (61%), were frequently associated with histologically and endoscopically normal fundic mucosa. Campylobacter pylori-associated active antral gastritis occurred only in subjects whose fundus harbored this organism. Plasma immunoglobulin G antibody titers to C. pylori were highest in subjects with Campylobacter-associated antral gastritis and lowest in subjects without gastric Campylobacter. These studies suggest that healthy humans may harbor C. pylori in their proximal stomach without apparent ill effects. In some of these individuals, the organism also involves the antrum and is associated with active gastritis.
authors.affiliation: Department of Internal Medicine, Dallas Veterans Administration Medical Center, Texas.
authors.forename: W L
authors.initials: WL
authors.lastname: Peterson
authors.forename: E
authors.initials: E
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Feldman
mesh_terms: D000328:Adult; D002167:Campylobacter / Q000276:immunology / Q000302:isolation & purification*; D005260:Female; D005748:Gastric Fundus / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D005753:Gastric Mucosa / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D005756:Gastritis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D011446:Prospective Studies; D011708:Pylorus / Q000276:immunology / Q000382:microbiology / Q000473:pathology
chemical_list: D007074:Immunoglobulin G; D007213:Indomethacin