title: A prospective, randomized, clinical trial of heparin therapy for postoperative intraocular fibrin.
abstract: The authors undertook a study to investigate the ability of systemic or heparin supplementation of the vitrectomy infusion solution to prevent formation of postoperative intraocular fibrin membranes. A total of 73 eyes were randomized; 26 served as the control group, 23 received 10,000 IU of intravenous bolus of heparin, and 12 eyes each underwent the vitrectomy with an infusion solution containing 10 or 5 IU/cc of heparin. Intraoperative bleeding, postoperative bleeding, and postoperative fibrin formation were graded. A 10-IU/cc heparin infusion resulted in a statistically significant reduction in postoperative fibrin formation (P = 0.04) but increased intraoperative bleeding (P = 0.02). A trend toward reduced postoperative fibrin formation was noted in the intravenous heparin and 5 IU/cc infusion groups.
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, School of Medicine, FL 33101.
authors.forename: R N
authors.initials: RN
authors.lastname: Johnson
authors.forename: G
authors.initials: G
authors.lastname: Blankenship
mesh_terms: D005337:Fibrin / Q000378:metabolism*; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D007431:Intraoperative Complications / Q000209:etiology; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D011897:Random Allocation; D013927:Thrombosis / Q000517:prevention & control; D014821:Vitrectomy / Q000009:adverse effects*; D014823:Vitreous Hemorrhage / Q000209:etiology
chemical_list: D005337:Fibrin; D006493:Heparin