Family data support a dominant major gene for Tourette syndrome.
A dominant major gene was supported by analyses of 50 large extended Tourette syndrome (TS) pedigrees and by a subset of families defined by proband's clinical response to the neuroleptic drug haloperidol. Relatives were defined as affected if they ever had tics or TS. Assuming a nearly even sex ratio for TS and related symptoms resulted in the best fit of the genetic model to observed rates in families.
Price
R A
RA
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia.
Pauls
D L
DL
Kruger
S D
SD
Caine
E D
ED
D002874:Chromosome Mapping; D005799:Genes, Dominant; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D010375:Pedigree; D005879:Tourette Syndrome / Q000188:drug therapy / Q000235:genetics*
D006220:Haloperidol