Schistosomiasis mansoni: immunodiagnosis aspects and search for an immunological marker related to therapeutic efficacy.
The recent findings on immunodiagnosis of schistosomiasis mansoni have shown that purified Schistosoma mansoni antigens do not provide maximum positivity. Therefore, the authors suggest the use of semi-purified antigens for diagnostic purposes. So far, no serological marker for cured patients as shown by negative stool examination was found. However, a tendency of IgG antibody titre decrease was observed, when egg antigen was used.
Kanamura
H Y
HY
Instituto de Medicina Tropical de São Paulo, Brasil.
Hoshino-Shimizu
S
S
Lima
D M
DM
Abrantes
C P
CP
da Silva
L C
LC
D000909:Antibodies, Helminth / Q000032:analysis*; D000947:Antigens, Helminth / Q000276:immunology / Q000302:isolation & purification; D015415:Biomarkers / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D010063:Ovum / Q000276:immunology; D011233:Precipitin Tests; D011237:Predictive Value of Tests; D012555:Schistosomiasis mansoni / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D012556:Schistosomicides / Q000627:therapeutic use
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D015415:Biomarkers; D007074:Immunoglobulin G; D012556:Schistosomicides