Effect of diclofenac sodium (Voltaren) on spermatogenesis of infertile oligospermic patients.
The effect of the prostaglandin synthesis inhibitor diclofenac sodium (Voltaren) on spermatogenesis in infertile oligospermic patients has been studied. Diclofenac sodium was given orally at a daily dose of 100 mg for 30 days. Seminal fluid parameters were evaluated. Group II with high levels of seminal prostaglandin showed a statistically significant increase in the number and motility of spermatozoa (p less than 0.01), whilst no significant variations were observed in patients of group I with normal values of seminal prostaglandin.
Moskovitz
B
B
Department of Urology, Rambam Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Lin
R
R
Nassar
S
S
Levin
D R
DR
D000328:Adult; D004008:Diclofenac / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000188:drug therapy*; D011453:Prostaglandins / Q000032:analysis; D012661:Semen / Q000032:analysis; D013091:Spermatogenesis / Q000187:drug effects*
D011453:Prostaglandins; D004008:Diclofenac