title: The effects of Norplant-2 rods on clinical chemistry in Singaporean acceptors after 1 year of use: haemostatic changes.
abstract: A longitudinal study of coagulation parameters was carried out on 100 Singapore acceptors using the levonorgestrel subdermal implants Norplant-2 rods for contraceptive purposes. At the end of 1 year of use, results from this on-going study indicates that these acceptors have an enhanced potential for hypercoagulation with a significant shortening of their prothrombin time and activated partial thromboplastin time. They also have an increased predisposition to thrombosis as evidenced by significant increases in platelet count and aggregability. A number of other parameters achieved statistically significant differences by the end of one year but since the results were within the normal accepted range, they were therefore unlikely to be of much clinical importance.
authors.affiliation: Department of Obstetrics and Gynaecology, National University of Singapore.
authors.forename: K
authors.initials: K
authors.lastname: Singh
authors.forename: O A
authors.initials: OA
authors.lastname: Viegas
authors.forename: S
authors.initials: S
authors.lastname: Koh
authors.forename: P
authors.initials: P
authors.lastname: Singh
authors.forename: S S
authors.initials: SS
authors.lastname: Ratnam
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D016912:Levonorgestrel; D008137:Longitudinal Studies; D009644:Norgestrel / Q000494:pharmacology*; D010314:Partial Thromboplastin Time; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D011517:Prothrombin Time; D012846:Singapore
chemical_list: D009644:Norgestrel; D016912:Levonorgestrel