Factors influencing the outcome of successive IVF treatment cycles in attaining a follicular puncture.
An analysis has been made on data from 576 cycles in 300 patients regarding the chances of various superovulation protocols attaining a puncture in successive cycles. The cumulative proportion of patients with at least one successful stimulation increased from 77% at the first attempt, to 98% at the fifth attempt. Of the 576 stimulations, 440 (76%) resulted in a puncture. Age, the number of ovaries and the reaction to superovulation induction contribute to the outcome of a cycle, the chances being lowest for older individuals with one ovary and an inadequate reaction in the first treatment cycle. Changing the treatment protocol did not improve the outcome in subsequent gonadotrophin-induced cycles, even if combined with clomiphene citrate. Reasons for cancellation did not tend to recur, although the incidence of dominance and premature stimulation was significantly higher in patients aged greater than 35 years. Age-dependent chances of success were calculated.
Scholtes
M C
MC
Department of Gynaecology and Obstetrics, Academic Hospital Rotterdam-Dijkzigt, Erasmus University, The Netherlands.
Hop
W C
WC
Alberda
A T
AT
Janssen-Caspers
H A
HA
Leerentveld
R A
RA
van Os
H C
HC
Zeilmaker
G H
GH
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use; D009865:Oocytes / Q000166:cytology; D006080:Ovarian Follicle / Q000502:physiology*; D013480:Superovulation; D014465:Ultrasonics
D006063:Chorionic Gonadotropin; D002996:Clomiphene; D008596:Menotropins