title: The metabolism and pharmacokinetics of fleroxacin in healthy subjects.
abstract: A 400 mg dose of fleroxacin was administered orally to six healthy male volunteers. Concentrations of fleroxacin and the N-demethyl and N-oxide metabolites were determined in serum and urine by HPLC. The serum metabolite levels were negligible. The N-oxide metabolite was measured in the serum of five subjects but did not exceed 4% of the corresponding fleroxacin level. N-demethyl fleroxacin was not detected (less than 0.1 mg/l). The urinary recovery of fleroxacin was 49.5% over 72 h; the N-demethyl and N-oxide metabolites accounted for 6.9% and 5.7%, respectively, of the administered dose.
authors.affiliation: Department of Microbiology, Dudley Road Hospital, Birmingham, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Griggs
authors.forename: R
authors.initials: R
authors.lastname: Wise
authors.forename: B
authors.initials: B
authors.lastname: Kirkpatrick
authors.forename: J P
authors.initials: JP
authors.lastname: Ashby
mesh_terms: D000890:Anti-Infective Agents / Q000378:metabolism* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics; D016576:Fleroxacin; D006801:Humans; D008297:Male
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D016576:Fleroxacin