Valproate in the treatment of rapid-cycling bipolar disorder.
Six consecutive patients with rapid-cycling bipolar disorder, refractory or only minimally responsive to treatment with lithium salts and neuroleptics, including five also refractory to carbamazepine, all demonstrated a moderate or marked response to the anticonvulsant valproate. These observations suggest that valproate may represent a promising treatment alternative in this often treatment-resistant form of bipolar disorder.
McElroy
S L
SL
Epidemiology Laboratory, McLean Hospital, Belmont, Massachusetts 02178.
Keck
P E
PE
Pope
H G
HG
Hudson
J I
JI
D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012569:Schizotypal Personality Disorder / Q000188:drug therapy; D014635:Valproic Acid / Q000627:therapeutic use*
D014635:Valproic Acid