Saccharin exposure increases the potency and aversive property of naloxone in drug-naive rats.
In naive rats previously given saccharin (0.1%) as the only drinking fluid for 14 days, naloxone produced a conditioned taste aversion at a dose (0.09 mg/kg, SC) that had little or no effect in normal controls. The magnitude of this effect of the saccharin increased between 2 and 7 days after cessation of the treatment. Under these experimental conditions, evidence of an interaction between the saccharin exposure and a naloxone response was also seen with rectal temperature measurements. Therefore, in rats having no history of morphine, previous consumption of saccharin may potentiate various actions of naloxone including its aversive property.
Walker
M J
MJ
Addiction Research Foundation of Ontario, Toronto, Canada.
Leavitt
B
B
Mucha
R F
RF
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D004357:Drug Synergism; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012439:Saccharin / Q000494:pharmacology*
D009270:Naloxone; D012439:Saccharin