[Postpartum definitive hypothyroidism. 7 cases].
Seven cases of hypothyroidism developed within 6 months of delivery are reported. Radioimmunoassays regularly showed very low thyroxin levels and high thyroid-stimulating hormone levels, thus confirming that the thyroid deficiency was of peripheral origin. A significant rise in antimicrosomal or antithyroglobulin antibodies was noted in 5 cases. One patient had HLA-B8 and 4 had HLA-DR3, which was not significantly different from the prevalence in the regional population. In contrast with the transient post-partum hypothyroidism reported mainly in Japan, the condition proved to be permanent in 6 patients followed up for more than two years. The increased frequency of HLA-DR3 and 5 recently described in thyroiditis with transient post-partum thyrotoxicosis was not found in our series. It would appear that pregnancy, which is a period of immune incompetence, may disclose a latent lymphocytic thyroiditis.
Houdent
C
C
Pellenc
P
P
Carrara Balacheff
O
O
Kuhn
J M
JM
Leclerc
P
P
Cavelier
B
B
Wolf
L M
LM
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000175:diagnosis; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology* / Q000276:immunology; D008861:Microsomes / Q000276:immunology; D011247:Pregnancy; D011644:Puerperal Disorders / Q000209:etiology* / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology; D013966:Thyroiditis / Q000175:diagnosis; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis; D013972:Thyrotropin / Q000097:blood; D013997:Time Factors
D001323:Autoantibodies; D006680:HLA Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D013972:Thyrotropin; D013954:Thyroglobulin
Hypothyroïdie définitive du post-partum. Sept observations.