Antigenic variation in parasitic protozoa.
Antigenic variation in the protozoan parasites responsible for malaria and African sleeping sickness is examined. Some of the molecular mechanisms responsible for the generation of new variant antigens are reviewed and the possible problems posed by this process in the development of vaccines against these parasites are discussed.
Langsley
G
G
Department of Immunology, Pasteur Institute, Paris, France.
Roth
C
C
D000818:Animals; D000940:Antigenic Variation; D000953:Antigens, Protozoan; D056890:Eukaryota / Q000276:immunology*; D006801:Humans; D008288:Malaria / Q000469:parasitology; D010961:Plasmodium / Q000254:growth & development / Q000276:immunology; D014345:Trypanosoma / Q000254:growth & development / Q000276:immunology; D014352:Trypanosomiasis / Q000469:parasitology; D014612:Vaccines / Q000302:isolation & purification
D000953:Antigens, Protozoan; D014612:Vaccines