G-proteins in the signal-transduction pathways of Dictyostelium discoideum.
The functional interaction of surface cAMP receptors with effector enzymes via G-proteins was investigated in Dictyostelium discoideum. Several experimental conditions were used to investigate signal transduction, such as reduced temperatures, use of down-regulated cells and of mutants. The results are presented as a model describing the complex interaction between multiple forms of the surface cAMP receptor and different G-proteins that are responsible for the generation of the second messengers, cAMP, cGMP, InsP3 and Ca2+.
Snaar-Jagalska
B E
BE
Cell Biology and Genetics Unit, Zoological Laboratory, Leiden, The Netherlands.
Kesbeke
F
F
Van Haastert
P J
PJ
D004023:Dictyostelium / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology*; D015398:Signal Transduction
D019204:GTP-Binding Proteins