title: [Gastroesophageal reflux in asthmatic and chronic bronchitis patients].
abstract: To determine the relationship between gastroesophageal (GE) reflux and pulmonary disease, we studied 21 asthmatics, 30 chronic bronchitics, 6 patients with GE reflux and no pulmonary symptoms, and 10 control subjects; GE reflux was diagnosed by pH monitoring and GE scintiscanning. Frequency of GE reflux in the asthmatics was 57%; in chronic bronchitis it was 56%. Pulmonary function tests did not show any differences between patients with or without reflux. The GE reflux episodes were more numerous but shorter in asthmatics than in chronic bronchitis. Patients with digestive symptoms alone were no different from chronic bronchitis with respect to reflux. The mechanism whereby reflux triggers pulmonary problems was investigated using the following 2 tests: scintiscan for pulmonary aspiration, and esophageal acid infusion (0.1N HCI). Six pulmonary aspirations were detected. Only asthmatics, with or without reflux, showed any significant variations in maximal expiratory flow at 50% and 25% of VC after HCI infusion. Thus, our results show that asthmatics differ from bronchitis patients by the characteristics of their reflux.
authors.forename: A
authors.initials: A
authors.lastname: Ducolone
authors.forename: A
authors.initials: A
authors.lastname: Vandevenne
authors.forename: H
authors.initials: H
authors.lastname: Jouin
authors.forename: J C
authors.initials: JC
authors.lastname: Grob
authors.forename: D
authors.initials: D
authors.lastname: Coumaros
authors.forename: C
authors.initials: C
authors.lastname: Meyer
authors.forename: G
authors.initials: G
authors.lastname: Burghard
authors.forename: G
authors.initials: G
authors.lastname: Methlin
authors.forename: L
authors.initials: L
authors.lastname: Hollender
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications* / Q000503:physiopathology; D001991:Bronchitis / Q000150:complications* / Q000503:physiopathology; D002908:Chronic Disease; D003964:Diaphragm / Q000503:physiopathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D006851:Hydrochloric Acid; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D011015:Pneumonia, Aspiration / Q000209:etiology; D011877:Radionuclide Imaging; D012129:Respiratory Function Tests
chemical_list: D006851:Hydrochloric Acid
vernacular_title: Reflux gastro-oesphagien chez les asthmatiques et les bronchitiques chroniques.