Definition of response and remission in children over one year of age with advanced neuroblastoma: proposition for a scoring system.
A two-step evaluation system is proposed to analyze the results of therapy for stage IV neuroblastoma in children over 1 year of age. Since most protocols consist of first-line chemotherapy followed by surgery and often high-dose chemotherapy with bone marrow rescue, "response" should assess the effect of chemotherapy alone and "remission" indicate the status after an attempt to remove the primary tumor. A scoring system is proposed for both steps. The comparability of different studies depends on the use of such common criteria to define patient groups and treatment results.
Philip
T
T
Centre Leon Berard, Lyon, France.
Helson
L
L
Bernard
J L
JL
Zucker
J M
JM
Kremens
B
B
Favrot
M
M
Hartmann
O
O
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D012074:Remission Induction