[Function of the membrane lipids of the heart sarcoplasmic network in izadrin myocarditis studied by using a pyrene probe].
The fluorescent hydrophobic pyrene probe was employed to study the viscosity of membrane lipids of rat heart sarcoplasmic reticulum in isoproterenol myocarditis. During pyrene incorporation into the reticulum obtained from the affected myocardium, the increase in the microviscosity occurred at lower temperatures and more rapidly both in "bound" and "free" membrane lipids as compared with normal. The increase of the viscosity of the reticulum membranes in isoproterenol myocarditis was accompanied by a lowering of the activity of Ca, Mg-ATPase of the sarcoplasmic reticulum coupled with an elevation of the content of lipid peroxidation products.
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D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D005456:Fluorescent Dyes; D007545:Isoproterenol; D008315:Malondialdehyde / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D009205:Myocarditis / Q000139:chemically induced / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D011721:Pyrenes; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*; D014783:Viscosity
D005456:Fluorescent Dyes; D008563:Membrane Lipids; D011721:Pyrenes; D008315:Malondialdehyde; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D007545:Isoproterenol
Issledovanie sostoianiia lipidov membran i sarekoplazmaticheskoĭ setiserdtsa pri izadrinovom miokardite s pomoshch'iu pirenovogo zonda.