Partial cross-reactivity by suppressor cells induced during different experimental autoimmune diseases.
Following injection of rat red cells, mice develop anti-red cell autoantibodies and subsequently suppressor T cells specific for these. Likewise, following recovery from non-lethal malaria, they develop suppressor T cells which suppress the anti-lymphocyte autoantibodies induced by lethal malaria parasites. Neither type of suppressor cell affected non-autoantibody components of the response, nor a response to sheep red cells. However, there was variable but significant cross-suppression of the respective autoantibody responses by both types of suppressor cell. Possible reasons for this unexpected cross-reaction are discussed.
Playfair
J H
JH
De Souza
J B
JB
Hutchings
P R
PR
Cooke
A
A
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D003429:Cross Reactions; D004912:Erythrocytes / Q000276:immunology; D008288:Malaria / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D010961:Plasmodium / Q000276:immunology; D010962:Plasmodium berghei / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D001323:Autoantibodies