In vitro interaction between cefotetan and aminoglycosides on Staphylococcus aureus and coagulase negative staphylococci, both methicillin-susceptible and -resistant.
The authors have evaluated the behavior of the interaction between cefotetan, a new cephalosporin with long acting resistance to the action of beta-lactamases, and gentamicin, amikacin and netilmicin against methicillin-susceptible and -resistant staphylococci. In 65.8% of the cases, drug combinations showed synergic effects. Results were subdivided for susceptibility or resistance to the drugs used in combination. In general, when both drugs were tested against methicillin-susceptible strains the results showed synergism.
Stefani
S
S
Institute of Microbiology, University of Catania, Italy.
Debbia
E
E
Schito
G C
GC
Nicoletti
G
G
D000583:Amikacin / Q000494:pharmacology; D000617:Aminoglycosides / Q000494:pharmacology*; D015313:Cefotetan / Q000494:pharmacology*; D003030:Coagulase / Q000032:analysis; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D005839:Gentamicins / Q000494:pharmacology; D008712:Methicillin / Q000494:pharmacology; D009428:Netilmicin / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*
D000617:Aminoglycosides; D003030:Coagulase; D005839:Gentamicins; D015313:Cefotetan; D009428:Netilmicin; D000583:Amikacin; D008712:Methicillin