title: Coincidence of gonadal dysgenesis and hyperprolactinemia.
abstract: It is reported about 4 female patients aged from 3 to 31 years (average age 18 years) with gonadal dysgenesis and hyperprolactinemia. Beside one all these females were not treated with synthetic sexual steroids. In 3 of the 4 patients both hyperprolactinemic and hypergonadotropic serum levels were observed. In one case the gonadotropic serum levels were normal. A stimulation test with GnRH-TRH or arginine-GnRH-TRH, respectively, was performed. In patients with gonadal dysgenesis a change on the area of hypothalamo-hypophyseal axis is supposed to cause the hyperprolactinemia.
authors.affiliation: Department of Gynaecology and Obstetrics, Wilhelm-Pieck-University of Rostock, GDR.
authors.forename: K
authors.initials: K
authors.lastname: Rudolf
authors.forename: S
authors.initials: S
authors.lastname: Kunkel
mesh_terms: D000293:Adolescent; D000328:Adult; D001120:Arginine; D002648:Child; D002675:Child, Preschool; D004958:Estradiol / Q000097:blood; D005260:Female; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000150:complications*; D010908:Pituitary Hormones, Anterior / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D014424:Turner Syndrome / Q000097:blood / Q000150:complications*
chemical_list: D010908:Pituitary Hormones, Anterior; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D013973:Thyrotropin-Releasing Hormone; D001120:Arginine