[Variability of sensitivity of lymphocytes from healthy donors to antiproliferative effect of dexamethasone and HLA antigens].
A positive correlation between the level of lymphocyte PHA-stimulation and the degree of stimulation inhibition by dexamethasone has been established. Using regression analysis methods, healthy volunteers were divided into three groups: sensitive, intermediate and resistant. The frequency of HLA-B7, B12 and DR2 antigens was increased in the latter group.
Kalashnikova
E A
EA
Pukhal'skiĭ
L A
LA
Pevnitskiĭ
L A
LA
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology*; D014644:Genetic Variation; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology
D006680:HLA Antigens; D010835:Phytohemagglutinins; D003907:Dexamethasone
Variabel'nost' chuvstvitel'nosti limfotsitov zdorovykh donorov k antiproliferativnomu deĭstviiu deksametazona i antigeny sistemy HLA.