title: The in vitro effects of amine fluorides on plaque bacteria.
abstract: Forty strains of bacteria which may be isolated from subgingival plaque were tested for their in vitro susceptibility to several amine fluorides and a commercial formulation (Elmex gel) containing these compounds. The amine fluorides were active against a wide range of plaque bacteria with gram-positive strains tending to be more sensitive than gram-negatives. The minimum inhibitory concentrations ranged from 45 to 1440 micrograms/ml with approximately half of the strains being inhibited at a concentration of 130 micrograms/ml of amine fluoride. The Elmex gel had a bactericidal effect on all of the strains tested and exhibited a rapid killing action at high dilutions. These in vitro findings suggest that amine fluorides may be useful in the treatment or prophylaxis of plaque-related diseases.
authors.affiliation: Department of Clinical Pathology and Immunology, Institute of Dental Surgery, London, England.
authors.forename: H M
authors.initials: HM
authors.lastname: Kay
authors.forename: M
authors.initials: M
authors.lastname: Wilson
mesh_terms: D000588:Amines / Q000494:pharmacology*; D000605:Amino Alcohols; D001419:Bacteria / Q000187:drug effects*; D002908:Chronic Disease; D003773:Dental Plaque / Q000382:microbiology*; D003959:Diamines; D005459:Fluorides / Q000494:pharmacology*; D006838:Hydrocarbons; D008826:Microbial Sensitivity Tests; D010510:Periodontal Diseases / Q000382:microbiology*
chemical_list: D000588:Amines; D000605:Amino Alcohols; D003959:Diamines; D006838:Hydrocarbons; C036238:amine fluoride 297; C495399:Olaflur; C013553:hexadecylamine; D005459:Fluorides; C008703:oleylamine