Anterior pituitary involvement in Wegener's granulomatosis.
Wegener's granulomatosis rarely involves the pituitary, and is limited to the posterior gland. A young woman developed sinusitis, otitis media, asymptomatic pulmonary density, blindness, and anterior pituitary hormone deficiency over 7 years. Mucosal biopsies showed only chronic necrotizing inflammation without vasculitis. Since her clinical course suggested an atypical presentation of Wegener's granulomatosis, cyclophosphamide was finally added to corticosteroid therapy. All symptoms but monocular blindness and hypopituitarism remitted.
Lohr
K M
KM
Department of Medicine, Veterans Administration Medical Center, Milwaukee, WI.
Ryan
L M
LM
Toohill
R J
RJ
Anderson
T
T
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001706:Biopsy; D001766:Blindness / Q000209:etiology; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology; D010902:Pituitary Gland / Q000473:pathology*; D012137:Respiratory System / Q000473:pathology
D000305:Adrenal Cortex Hormones; D003520:Cyclophosphamide