Factors attenuating growth promoting effect of growth hormone therapy for Turner's syndrome.
Nine patients with Turner's syndrome aged 7 to 13 years were treated with recombinant human growth hormone (hGH) at a dose of 0.5 or 1.0 U/kg/w for 1 year. In five of them the growth rate was accelerated from 3.3 +/- 0.6 (SD) to 6.5 +/- 0.5 cm/y (group A), whereas 4 had a reduced rate of growth promotion (3.4 +/- 0.3 to 4.6 +/- 0.4 cm/y) (group B). Analysis of factors affecting growth response to hGH revealed 3 major parameters: (1) age of initiating hGH therapy (A, 9.5 +/- 2.1 vs B, 13.3 +/- 0.4 yrs, P less than 0.01), (2) basal LH (A, 3.2 +/- 2.4 vs, B, 44.9 +/- 17.8 mIU/ml, P less than 0.001) and FSH levels (A, 14.7 +/- 15.4 vs B, 131 +/- 49 mIU/ml; P less than 0.01) and (3) somatomedin-C (SM-C) producing capacity: coefficient of correlation to growth rate, r = 0.80, P less than 0.01). No remarkable changes were observed in the results of glucose tolerance, thyroid state, calcium metabolism and liver function tests. These results indicate that patient's age is the most crucial factor in effective treatment with hGH, and in adolescent girls, gonadal failure with a limited increase in SM-C production attenuates the growth promoting potency of hGH.
Sato
T
T
Department of Pediatrics, School of Medicine, Kanazawa University, Japan.
Miyamori
C
C
Kajiwara
S
S
Miyagawa
K
K
Shimizu
M
M
D000293:Adolescent; D002648:Child; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000097:blood; D006130:Growth Disorders / Q000209:etiology; D013006:Growth Hormone / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D011994:Recombinant Proteins / Q000627:therapeutic use; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014424:Turner Syndrome / Q000188:drug therapy*
D005640:Follicle Stimulating Hormone; D006442:Glycated Hemoglobin; D013006:Growth Hormone; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone; D011994:Recombinant Proteins; D013972:Thyrotropin; D013974:Thyroxine; D014284:Triiodothyronine