title: In-vitro activity of fleroxacin against urinary tract and genital tract pathogens.
abstract: The activity of fleroxacin was compared to those of nalidixic acid, ampicillin, trimethoprim-sulphamethoxazole, tetracycline and penicillin against a total of 452 strains isolated from urinary tract and genital tract infections. These included strains resistant to gentamicin, methicillin-resistant Staphylococcus aureus and beta-lactamase producing strains. MICs were determined by a standard agar dilution procedure using Mueller-Hinton agar. Fleroxacin inhibited 90% of Escherichia coli, Klebsiella pneumoniae, Proteus spp., and Enterobacter spp. at less than or equal to 1 mg/l. All the gentamicin-resistant Enterobacteriaceae strains were highly susceptible to fleroxacin (MIC90 less than or equal to 0.5 mg/l). Against Pseudomonas, fleroxacin was the most active agent tested (MIC90 2 mg/l). All nalidixic acid-resistant strains were susceptible to fleroxacin (MIC90 less than or equal to 1 mg/l). The activity of fleroxacin was similar against methicillin-resistant and methicillin-susceptible strains of Staph. aureus (MIC90 less than or equal to 0.5 mg/l). Against Neisseria gonorrhoeae, fleroxacin (MIC90 0.12 mg/l) was as active as penicillin and tetracycline. However against N. gonorrhoeae strains producing beta-lactamase, fleroxacin (MIC90 0.5 mg/l) was at least twice as active as tetracycline. Fleroxacin is a potent quinolone with in-vitro activity against a variety of resistant bacterial species.
authors.affiliation: Centre Hospitalier Hôtel-Dieu de Sherbrooke, Québec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Dubois
authors.forename: V
authors.initials: V
authors.lastname: Fontaine
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D016576:Fleroxacin; D005831:Genital Diseases, Female / Q000188:drug therapy; D005832:Genital Diseases, Male / Q000188:drug therapy; D008297:Male; D009268:Nalidixic Acid / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D013754:Tetracyclines / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D010406:Penicillins; D013754:Tetracyclines; D009268:Nalidixic Acid; D002939:Ciprofloxacin; D000667:Ampicillin; D014295:Trimethoprim; D016576:Fleroxacin