title: Juvenile myoclonic epilepsy (JME) may be linked to the BF and HLA loci on human chromosome 6.
abstract: Although certain forms of epilepsy have long been suspected to be inherited, heterogeneity has made it difficult to find the genes responsible for any subtypes. We found that families ascertained through patients with juvenile myoclonic epilepsy show linkage with the BF and HLA loci on human chromosome 6. There is some evidence that the locus may be outside the HLA complex and no evidence as yet of an association with any allele of the HLA complex.
authors.affiliation: Comprehensive Epilepsy Program, VA Medical Center West Los Angeles 90073.
authors.forename: D A
authors.initials: DA
authors.lastname: Greenberg
authors.forename: A V
authors.initials: AV
authors.lastname: Delgado-Escueta
authors.forename: H
authors.initials: H
authors.lastname: Widelitz
authors.forename: R S
authors.initials: RS
authors.lastname: Sparkes
authors.forename: L
authors.initials: L
authors.lastname: Treiman
authors.forename: H M
authors.initials: HM
authors.lastname: Maldonado
authors.forename: M S
authors.initials: MS
authors.lastname: Park
authors.forename: P I
authors.initials: PI
authors.lastname: Terasaki
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002896:Chromosomes, Human, Pair 6; D011415:Complement Factor B / Q000235:genetics*; D004792:Enzyme Precursors / Q000235:genetics*; D004831:Epilepsies, Myoclonic / Q000235:genetics* / Q000276:immunology; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers / Q000032:analysis; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree
chemical_list: D004792:Enzyme Precursors; D005819:Genetic Markers; D006680:HLA Antigens; D011415:Complement Factor B