title: A mechanism for the potentiation of the cytotoxic effects of antimetabolites drugs (FT-207, 5FU) by hyperthermia.
abstract: This study demonstrates that the cytotoxicity of FT-207 was potentiated with elevated temperatures. This result leads us to the hypothesis that the heat-produced superoxide radicals could metabolize and degradate FT-207 to 5FU at membrane or cytoplasm.
authors.affiliation: First Department of Surgery, Okayama University Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Iwagaki
authors.forename: S
authors.initials: S
authors.lastname: Fuchimoto
authors.forename: S
authors.initials: S
authors.lastname: Shiiki
authors.forename: M
authors.initials: M
authors.lastname: Miyake
authors.forename: K
authors.initials: K
authors.lastname: Orita
mesh_terms: D002460:Cell Line / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms / Q000201:enzymology / Q000473:pathology*; D003131:Combined Modality Therapy; D003600:Cytosol / Q000201:enzymology; D005472:Fluorouracil / Q000494:pharmacology*; D006358:Hot Temperature; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects; D013385:Succinate Dehydrogenase / Q000032:analysis; D005641:Tegafur / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014410:Tumor Stem Cell Assay
chemical_list: D005641:Tegafur; D013385:Succinate Dehydrogenase; D005472:Fluorouracil