title: Prognostic indicators in centroblastic-centrocytic lymphoma.
abstract: The prognostic importance of ploidy and proliferative index (%S + G2) assessed by flow cytometry, mitotic and centroblast counts, and histological growth pattern were evaluated in biopsy specimens taken before treatment from 60 cases of centroblastic-centrocytic non-Hodgkin's lymphoma. Cases with a high proliferative index (greater than or equal to 18%) or DNA aneuploidy showed significantly poorer survival than those with a low proliferative index (less than 18%). A high mitotic count was also associated with a poor prognosis. On multiple regression analysis the flow cytometric assessments and mitotic counts were significant predictors of survival. Assessments of proliferative activity clearly have prognostic potential in centroblastic-centrocytic lymphoma and may permit more accurate characterisation of individual tumours.
authors.affiliation: Department of Pathology, University of Leeds.
authors.forename: N R
authors.initials: NR
authors.lastname: Griffin
authors.forename: M R
authors.initials: MR
authors.lastname: Howard
authors.forename: P
authors.initials: P
authors.lastname: Quirke
authors.forename: C J
authors.initials: CJ
authors.lastname: O'Brien
authors.forename: J A
authors.initials: JA
authors.lastname: Child
authors.forename: C C
authors.initials: CC
authors.lastname: Bird
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008938:Mitosis; D011379:Prognosis; D013997:Time Factors
chemical_list: D004273:DNA, Neoplasm