Voluntary exercise, food intake, and plasma metabolites in streptozotocin-diabetic Syrian hamsters.
Diabetes mellitus was induced in Syrian hamsters by treatment with streptozotocin. The efficacy of and survival from this treatment are compared across several drug regimens, and in exercising versus sedentary hamsters. Stable diabetes, with plasma glucose levels typically below 400 mg/dl, is accompanied by a decrease of approximately 50% in voluntary wheel running in a 14L:10D cycle. Wheel running in diabetics is, however, almost completely abolished in continuous light. The diabetic hamsters are hyperphagic on chow, eating about 60% more than controls, exclusively by increasing the size of individual meals. Their intake is normalized on a high fat diet. The high fat diet greatly exacerbates the extant ketonemia in diabetics, and produces hypertriglyceridemia. Exercise has no apparent effect on plasma metabolic fuels of diabetic hamsters.
Rowland
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N
Caputo
F A
FA
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D006224:Cricetinae; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004041:Dietary Fats / Q000008:administration & dosage; D005247:Feeding Behavior / Q000502:physiology*; D007659:Ketones / Q000097:blood; D008027:Light; D008297:Male; D008647:Mesocricetus; D009043:Motor Activity / Q000502:physiology*; D013311:Streptozocin; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D004041:Dietary Fats; D007659:Ketones; D014280:Triglycerides; D013311:Streptozocin