title: Intracellular mechanisms of contraction in the hypertensive and normotensive rat aortas.
abstract: The roles of intracellular mechanisms of contraction were compared in aortas from genetically hypertensive and normotensive rats by investigating the contractile activities of prostaglandin F2 alpha (PGF2 alpha) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in the absence of extracellular calcium. PGF2 alpha induced a greater amount of tension in aortic strips from hypertensive than normotensive rats. Furthermore, in hypertensive but not normotensive rat aortas, PGF2 alpha- and TPA-induced contractions were additive and were capable of sustaining a near maximum degree of muscle activation. Therefore, the intracellular contractile mechanisms in hypertensive vascular tissue may differ from those in normotensive tissue.
authors.affiliation: Division of Immunopharmacology, Wyeth-Ayerst Laboratories, Princeton, NY 08543-8000.
authors.forename: R J
authors.initials: RJ
authors.lastname: Heaslip
authors.forename: B D
authors.initials: BD
authors.lastname: Sickels
mesh_terms: D000818:Animals; D001011:Aorta / Q000503:physiopathology; D015237:Dinoprost; D006973:Hypertension / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000502:physiology*; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D011460:Prostaglandins F; D015237:Dinoprost; D013755:Tetradecanoylphorbol Acetate