Synthesis and antineoplastic evaluation of 1,4-bis(aminoalkanamido)-9,10-anthracenediones.
The effect of the replacement of amino groups, attached to the anthraquinone ring in [(aminoalkyl)amino]-anthraquinones, by an amido function on DNA binding, cytotoxicity, and antileukemic activity has been studied. The corresponding 1,4-bis(aminoalkanamido)-9,10-anthracenediones have been synthesized and examined. It has been concluded that such modification does not exclude the DNA binding and cytotoxicity of mentioned compounds but decreases or abolishes the in vivo antileukemic activity.
Martelli
S
S
Department of Chemical Sciences, University of Camerino, Italy.
Dzieduszycka
M
M
Stefanska
B
B
Bontemps-Gracz
M
M
Borowski
E
E
D000818:Animals; D000880:Anthraquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000378:metabolism; D007939:Leukemia L1210 / Q000473:pathology; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000880:Anthraquinones; D000970:Antineoplastic Agents; D004247:DNA