Effects of PGF2 alpha on the active Arthus reaction in rat and rabbit tongues.
The effect of the prostaglandin PGF2 alpha on the active Arthus reaction was examined in 20 young male rats and 12 young male rabbits because this local inflammatory reaction caused by immunocomplexes is very similar to a recurrent oral disease on humans called Sutton aphthosis, and because the amount of PGF2 alpha is higher than that of other PGs in the oral mucosa. In our experiments, the PGF2 alpha caused a very rapid and quickly-disappearing Arthus reaction when the sensitisation was pretreated by PGF2 alpha. Moreover the PGF2 alpha caused a very intensive and long-persisting Arthus reaction when the local evocation was prepared by PGF2 alpha pretreatment. The cardinal clinical symptom of the reaction was the marked oedema caused by PGF2 alpha. In the histological picture, the Arthus reaction was more intense after PGF2 alpha pretreatment. The PGF2 alpha is capable of influencing both the intensity and the duration of the Arthus reaction.
Terner
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Jávor
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D000818:Animals; D001183:Arthus Reaction / Q000473:pathology / Q000503:physiopathology*; D015237:Dinoprost; D008297:Male; D011460:Prostaglandins F / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D014059:Tongue / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*
D011460:Prostaglandins F; D015237:Dinoprost