[Pathomorphological criteria of anti-atherosclerotic effect of plant saponins in an experiment].
6-month hypercholesterol diet made it possible to obtain an adequate model of atherosclerosis in inbred rats. The model was characterized by lipoidosis and fibrous plaques which occupied half of the area of the aorta and coronary arteries, as well as secondary fibrosis of other organs. During atherogenesis changes in endothelial and myocyte cells appear, accumulation of acid glycosaminoglycans takes place, lipoidosis and elastofibrosis progress up to collagenization and hyalinosis of the arterial wall. Fibro-myocyte plaques are transformed into fibro-atheromatous plaques. Upon drug therapy with vegetative saponins and furastonolic glycosides fibrous lesions did not regress, but delipidization and translocation of glycosaminoglycans were observed in 30% of the area of the affected arteries, and elastofibrosis and changes in endothelial and myocyte cells were decreased. Long-term therapy with vegetative drugs produced a regression of the experimental atherosclerosis.
Ryff
I M
IM
Krepkova
L V
LV
Arzamastseva
E V
EV
Rudzhianskaĭte
A F
AF
Puchkova
V A
VA
D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology* / Q000517:prevention & control; D001835:Body Weight / Q000187:drug effects; D004036:Diet, Atherogenic; D004562:Electrocardiography; D008297:Male; D051381:Rats; D012503:Saponins / Q000494:pharmacology* / Q000627:therapeutic use
D012503:Saponins
Patomorfologicheskie kriterii antiateroskleroticheskogo deĭstviia saponinov rastitel'nogo proiskhozhdeniia v éksperimente.