Rectal absorption of flecainide acetate.
The rectal absorption of flecainide from an aqueous solution, a fatty suppository and a polyethyleneglycol suppository was studied in one patient with supraventricular tachycardia (Wolff-Parkinson-White syndrome) refractory for oral anti-arrhythmic treatment. Rectal absorption was found to be fast (t1/2abs = 1 h) and complete when flecainide was administered as a solution (relative bioavailability 100%). Flecainide was poorly absorbed from a fatty suppository. The polyethyleneglycol suppository gave absorption with a relative bioavailability of 80% and t1/2 abs = 1.2 h.
Lie-A-Huen
L
L
Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands.
Kingma
J H
JH
D000328:Adult; D001682:Biological Availability; D005424:Flecainide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D012007:Rectum / Q000378:metabolism*; D013050:Spectrometry, Fluorescence; D013270:Stomach / Q000601:surgery; D013488:Suppositories
D013488:Suppositories; D005424:Flecainide