Secretion of IgE-specific potentiating factors by human Fc epsilon R+ T cell lines.
In the present study, Fc epsilon R+ and Fc epsilon R- T cells were isolated from patients with the hyper-IgE syndrome and maintained in long-term cultures with interleukin 2. Supernatants from the Fc epsilon R+ but not from the Fc epsilon R- T cell lines enhanced IgE but not IgG synthesis in B cells derived from patients with allergic rhinitis. There was, however, no induction of IgE synthesis in B cells from nonatopic donors. The IgE-potentiating factors bound to IgE-Sepharose but not to IgG-Sepharose. The target B cells for these IgE binding factors appear to be preactivated IgE-bearing B cells.
Leung
D Y
DY
Young
M C
MC
Geha
R S
RS
D001402:B-Lymphocytes / Q000276:immunology; D002460:Cell Line; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis; D008222:Lymphokines / Q000276:immunology*; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc / Q000276:immunology*; D017455:Receptors, IgE; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D007074:Immunoglobulin G; D008222:Lymphokines; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc; D017455:Receptors, IgE; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors; D007073:Immunoglobulin E