title: Bio-electric conductivity potentials in experimental skin grafts.
abstract: Prior investigations have established that changes in bio-electric potentials accompany the processes of wound creation and healing. In order to investigate these changes in an experimental full-thickness skin graft model, grafts were harvested from the dorsa of eight albino rabbits. Changes in potential were recorded over a period of 32 days, using silver-silver chloride electrodes and a recording polygraph. The potential measured across the skin graft became increasingly more electropositive until, between days 1 and 2, the potential abruptly reversed polarity. This negative potential lasted until day 4, when the conductivity again became positive, with a slow return to baseline measurements by day 32. Although these observations may indicate a bio-electric counterpart to the cellular events of wound healing, more study is needed.
authors.affiliation: Department of Ophthalmology, University of Wisconsin Medical School, Madison.
authors.forename: R C
authors.initials: RC
authors.lastname: Angrist
authors.forename: R S
authors.initials: RS
authors.lastname: Gonnering
authors.forename: R K
authors.initials: RK
authors.lastname: Dortzbach
authors.forename: K
authors.initials: K
authors.lastname: Crawford
mesh_terms: D000818:Animals; D003217:Conductometry; D004594:Electrophysiology; D008839:Microelectrodes; D011817:Rabbits; D016038:Skin Transplantation; D014945:Wound Healing / Q000502:physiology*