title: Hyperunstable hemoglobin Koriyama anti-Hb Gun Hill insertion of five residues in the beta chain.
abstract: A new hyperunstable hemoglobin was found in a Japanese girl who had very severe, chronic hemolytic anemia. Her parents and siblings were hematologically normal. The abnormal hemoglobin comprised a very small proportion of the total hemoglobin, although it was produced almost at the same rate as normal hemoglobin. Sequencing of an abnormal peptide which was liberated from the beta chain by hydrolysis with a protease from Staphylococcus aureus V8 disclosed the tandem insertion of a five-residue segment which included the proximal histidine at beta 92(F8).
authors.affiliation: Department of Clinical Laboratory Science, Yamaguchi University School of Medicine, Ube, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Kawata
authors.forename: Y
authors.initials: Y
authors.lastname: Ohba
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Miyaji
authors.forename: R
authors.initials: R
authors.lastname: Makita
authors.forename: K
authors.initials: K
authors.lastname: Ohga
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Miwa
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D005260:Female; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D007223:Infant; D008969:Molecular Sequence Data; D009154:Mutation; D010446:Peptide Fragments
chemical_list: D006455:Hemoglobins, Abnormal; D010446:Peptide Fragments; C048651:hemoglobin Gun Hill; C057242:hemoglobin Koriyama