[Regions of human genome-containing analogs of oncogenes and retroviral genes. II. A new class of retrovirus-like elements].
Earlier we have found that recombinant phage lambda gp5 contains the sequences homologous to v-mos oncogene and retroviruses. After the nucleotide sequence determination we have found the region with homology to U5 part of retroviral LTR. Adjacent to this region are sequences complementary to 3'-end of tRNAMet. Numerous transcripts reacting with subcloned U5 probe from gp5 are present in polyadenylated RNA fraction from human cells. The humane genome contains several copies of these region, with two of them residing in gp5 locus. On the basis of these data we deduced the presence in the human genome of a new class of retroviral-like elements, existing probably as part of new human endogeneous retrovirus (HuEV).
Chumakov
I M
IM
Zabarovskiĭ
E R
ER
Prasolov
V S
VS
Mett
V L
VL
Kiselev
L L
LL
D010582:Bacteriophage lambda / Q000235:genetics; D002874:Chromosome Mapping; D005814:Genes, Viral; D006023:Glycoproteins / Q000235:genetics; D006367:HeLa Cells; D006801:Humans; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D012091:Repetitive Sequences, Nucleic Acid; D012190:Retroviridae / Q000235:genetics*; D013045:Species Specificity
D006023:Glycoproteins
Uchastki genoma cheloveka, soderzhashchie analogi onkogenov i genov retrovirusov. II. Novyĭ klass retrovirusopodobnykh élementov.