Chronic pancreatitis, HLA and autoimmunity.
HLA-A and B antigens were studied in 88 Caucasoids with chronic pancreatitis resident in the Manchester area. In the subgroup of 52 patients with alcohol-related chronic pancreatitis HLA-B21 was significantly increased in frequency compared with 344 local controls (Pc = 0.0128). In the non-alcoholic sub-group of 36 patients, the incidence of HLA-A1 was significantly higher than in controls (Pc = 0.0021); whilst HLA-B8 was present in 38.8% of patients and 27.9% of controls. When these data are amalgamated with data from Lyon (France), the antigen HLA-A1 is significantly associated with non-alcoholic chronic pancreatitis.
Anderson
R J
RJ
University Department of Gastroenterology, Manchester Royal Infirmary, U.K.
Dyer
P A
PA
Donnai
D
D
Klouda
P T
PT
Jennison
R
R
Braganza
J M
JM
D000437:Alcoholism / Q000150:complications; D001327:Autoimmune Diseases / Q000150:complications*; D002137:Calculi / Q000150:complications; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000150:complications / Q000276:immunology*
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens