A unique pattern of proto-oncogene abnormalities in ovarian adenocarcinomas.
Twelve cases of ovarian adenocarcinoma were studied for alterations in proto-oncogenes, and a unique pattern of altered ras proto-oncogenes was observed. Amplification of ras-Ki was found in three of seven ovarian tumors and amplification of ras-Ha in one of 12. In contrast, ras-Ha amplification was not found in any of the 334 other tumors and ras-Ki amplification was only seen in breast cancer at a frequency of 3%. Other proto-oncogenes altered in ovarian adenocarcinomas included c-myc and c-erbb-2. Proto-oncogene abnormalities were more frequent in aggressive tumors of high histologic grade.
Zhou
D J
DJ
Department of Medicine, UCLA School of Medicine 90024.
Gonzalez-Cadavid
N
N
Ahuja
H
H
Battifora
H
H
Moore
G E
GE
Cline
M J
MJ
D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D005260:Female; D005784:Gene Amplification; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes