title: Effect of fluoridated sucrose on rat caries.
abstract: The present study was designed to test the effect of frequent pulses of low fluoride levels on rat caries when supplied in a standardized cariogenic rat diet containing 67% sucrose (MIT-200). The test diets were variants of Diet MIT-200 in which the sucrose component had been fluoridated with NaF solution resulting in total concentrations of 0 (control), 2, 3, 5, 10, or 20 ppm fluoride in the final diets. Rats received one of the test lots 17 times daily in a programmed feeding machine beginning at age 22 days, and were inoculated with Streptococcus mutans at age 23, 24, and 25 days. After 5 weeks, the rats were sacrificed and their mandibular molars scored for number and severity of sulcal, buccolingual, and proximal caries. Frequent daily pulses of as little as 2 ppm fluoride in dietary sucrose were effective in significantly (p less than 0.01) reducing buccolingual rat caries.
authors.affiliation: Eastman Dental Center, Rochester, N.Y.
authors.forename: S A
authors.initials: SA
authors.lastname: Mundorff
authors.forename: D
authors.initials: D
authors.lastname: Glowinsky
authors.forename: C J
authors.initials: CJ
authors.lastname: Griffin
authors.forename: J H
authors.initials: JH
authors.lastname: Stein
authors.forename: L M
authors.initials: LM
authors.lastname: Gwinner
mesh_terms: D000818:Animals; D001835:Body Weight; D003731:Dental Caries / Q000378:metabolism / Q000382:microbiology / Q000517:prevention & control*; D003773:Dental Plaque / Q000382:microbiology; D004037:Diet, Cariogenic; D005459:Fluorides / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012463:Saliva / Q000382:microbiology; D013295:Streptococcus mutans / Q000187:drug effects / Q000302:isolation & purification; D013395:Sucrose / Q000494:pharmacology*
chemical_list: D013395:Sucrose; D005459:Fluorides