title: Ceftizoxime level in the myocardium (right atrial muscle and mitral papillary muscle) during open heart surgery.
abstract: We determined the level of sodium ceftizoxime (CZX) in the right atrium and mitral papillary muscle of 22 adults and 6 children undergoing open-heart surgery, 60 and 120 minutes after intravenous administration of this drug at the dosages of 2 grams for adults and 1 gram for children. The CZX level in the right atrial muscle after 60 minutes was 37.0 micrograms/g in adults and 51.0 micrograms/g in children. The CZX level in the papillary muscle of the mitral valve, determined at 120 minutes was 16.9 micrograms/g. In the present study, we measured the level of the antibiotic CZX in the myocardial tissue during open-heart surgery. The purpose of this was to determine the quantity in which the antibiotic is taken into the myocardial tissue.
authors.affiliation: Second Department of Surgery, Yamagata University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Washio
authors.forename: H
authors.initials: H
authors.lastname: Eishin
authors.forename: T
authors.initials: T
authors.lastname: Shimanuki
authors.forename: H
authors.initials: H
authors.lastname: Orita
authors.forename: T
authors.initials: T
authors.lastname: Sato
mesh_terms: D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood; D015296:Ceftizoxime; D002648:Child; D002675:Child, Preschool; D006325:Heart Atria / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000032:analysis; D009206:Myocardium / Q000032:analysis*; D010210:Papillary Muscles / Q000032:analysis*; D013997:Time Factors
chemical_list: D015296:Ceftizoxime; D002439:Cefotaxime