Superparamagnetic particles as an MRI contrast agent for the gastrointestinal tract.
Non-biodegradable superparamagnetic particles containing magnetite were evaluated as a potential contrast agent for the gastrointestinal tract. The particles were administered to pigs perorally either suspended in water or mixed with food. The gastrointestinal tract structures were excellently depicted through a lowered signal intensity of their content in both T1 and T2 weighted images. Relatively large volumes with low particle concentration seemed to give a good contrast agent distribution, especially when the administration was extended over a period of time. Problems with artefacts and blurring in the images caused by a too high local concentration of the contrast agent should also be minimized by using low particle concentrations.
Lönnemark
M
M
Department of Diagnostic Radiology, Akademiska Sjukhuset, University of Uppsala, Sweden.
Hemmingsson
A
A
Carlsten
J
J
Ericsson
A
A
Holtz
E
E
Klaveness
J
J
D000818:Animals; D003287:Contrast Media; D004064:Digestive System / Q000033:anatomy & histology*; D052203:Ferrosoferric Oxide; D007501:Iron; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D010087:Oxides; D013552:Swine
D003287:Contrast Media; D010087:Oxides; D007501:Iron; D052203:Ferrosoferric Oxide