The maximum of the histone acetyltransferase activity precedes DNA-synthesis in regenerating rat liver.
A pronounced transitory increase of histone acetyltransferase (EC 2.3.1.48) activity before the onset of DNA replication is shown to occur in regenerating rat liver. This effect is followed by an increase in the H1/H1(0) ratio at the start of DNA synthesis; H1(0) de is replaced by H1. Histone acetylation and H1/H1(0) exchange are discussed as steps in the signal transduction for DNA replication.
Weiss
G
G
Institut für Medizinische Chemie und Biochemie, Universität Innsbruck, Austria.
Puschendorf
B
B
D000085:Acetates / Q000378:metabolism; D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication; D051548:Histone Acetyltransferases; D007700:Kinetics; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D029701:Saccharomyces cerevisiae Proteins; D013997:Time Factors
D000085:Acetates; D029701:Saccharomyces cerevisiae Proteins; D004247:DNA; D000123:Acetyltransferases; D051548:Histone Acetyltransferases