Pigmentation of the jawbones and teeth secondary to minocycline hydrochloride therapy.
Oral pigmentation due to minocycline hydrochloride (Minocin) therapy is an unusual and infrequently reported side effect of the drug. This report describes a patient on long-term minocycline therapy who presented with gingival pigmentation. Upon surgical exploration, the gingiva was noted to be normal in color, but the underlying bone was deeply pigmented. Via fluorescent microscopy, minocycline deposition within the alveolar bone was demonstrated.
Cale
A E
AE
Department of Dentistry, Booth Memorial Medical Center, Flushing, NY 11355.
Freedman
P D
PD
Lumerman
H
H
D000328:Adult; D000539:Alveolar Process / Q000187:drug effects* / Q000473:pathology; D005882:Gingival Diseases / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008911:Minocycline / Q000009:adverse effects*; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000473:pathology; D013754:Tetracyclines / Q000009:adverse effects*
D013754:Tetracyclines; D008911:Minocycline