title: Kinetic characterization of dopamine as a suicide substrate of tyrosinase.
abstract: A kinetic study of the inactivation of frog epidermis tyrosinase by a suicide substrate dopamine hydrochloride is described. The kinetic parameters and constants which characterize this reaction have been determined and the effects of pH and the stoichiometric inhibition by chloride have been considered.
authors.affiliation: Departmento de Bioquimica, Facultad de Medicina, Universidad de Murcia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Tudela
authors.forename: F
authors.initials: F
authors.lastname: Garcia-Canovas
authors.forename: R
authors.initials: R
authors.lastname: Varón
authors.forename: M
authors.initials: M
authors.lastname: Jimenez
authors.forename: F
authors.initials: F
authors.lastname: Garcia-Carmona
authors.forename: J A
authors.initials: JA
authors.lastname: Lozano
mesh_terms: D000818:Animals; D004156:Catechol Oxidase / Q000037:antagonists & inhibitors*; D004298:Dopamine / Q000378:metabolism / Q000494:pharmacology*; D004817:Epidermis / Q000201:enzymology; D007700:Kinetics; D008433:Mathematics; D008962:Models, Theoretical; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D011898:Ranidae
chemical_list: D004156:Catechol Oxidase; D014442:Monophenol Monooxygenase; D004298:Dopamine