Comparison of anti-inflammatory compounds in the carrageenan induced paw edema model and the reversed passive Arthus model utilizing the same animal.
In order to better define antiinflammatory activity in new agents, a test was devised utilizing both carrageenan induced paw edema and the reversed passive Arthus reaction in the same animal. The model of carrageenan induced rat paw edema is a standard laboratory assay used to predict classical "aspirin-like" antiinflammatory molecules. The reversed passive cutaneous Arthus reaction involves precipitating antigen-antibody complexes, complement and infiltrating polymorphonuclear leukocytes (PMN's) and can be used to identify agents that affect one or more of these factors specifically. Antiinflammatory compounds were given orally one hour prior to the administration of carrageenan and goat anti-rat serum. Comparisons were made between several non-steroidal compounds and the steroid hydrocortisone. All of the compounds tested gave good carrageenan activity, but only hydrocortisone produced significant Arthus lesion inhibition in this assay.
Reiter
M J
MJ
Schwartzmiller
D H
DH
Swingle
K F
KF
Moore
G G
GG
Goldlust
M B
MB
Heghinian
K
K
DeVore
D P
DP
Choy
B
B
Weppner
W A
WA
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001183:Arthus Reaction; D002351:Carrageenan; D004195:Disease Models, Animal; D004487:Edema / Q000209:etiology; D006854:Hydrocortisone / Q000494:pharmacology; D051381:Rats
D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D006854:Hydrocortisone