title: Pectin delays gastric emptying and increases satiety in obese subjects.
abstract: As pectin delays gastric emptying in normal subjects and satiety may be linked to the rate of gastric emptying, we designed this study to evaluate, in a group of obese subjects, the effect of adding pectin to a meal on gastric emptying, sensation of satiety, and postprandial plasma cholecystokinin and pancreatic polypeptide levels. We studied gastric emptying of solids in 9 adult obese subjects on 2 separate days in a randomized fashion. On day 1, 15 g of pectin was added to the meal, and on day 2 15 g of methylcellulose was added and served as control. Satiety was evaluated by an analogue rating scale. Pectin significantly delayed gastric emptying time [t1/2 = 116 +/- 23 min vs. 71 +/- 17 min observed with methylcellulose (p less than 0.001)]. Pectin also significantly increased subjects' sensation of satiety [98 +/- 7 vs. 74 +/- 17 (p less than 0.001)]. Postprandial release of cholecystokinin and pancreatic polypeptide was not modified by pectin. As pectin induces satiety and delays gastric emptying in obese patients, it may be a useful adjuvant in the treatment of disorders of overeating.
authors.affiliation: Department of Medicine, Los Angeles County-University of Southern California Medical Center.
authors.forename: C
authors.initials: C
authors.lastname: Di Lorenzo
authors.forename: C M
authors.initials: CM
authors.lastname: Williams
authors.forename: F
authors.initials: F
authors.lastname: Hajnal
authors.forename: J E
authors.initials: JE
authors.lastname: Valenzuela
mesh_terms: D000328:Adult; D002766:Cholecystokinin / Q000097:blood; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D008747:Methylcellulose / Q000494:pharmacology; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000503:physiopathology*; D010191:Pancreatic Polypeptide / Q000097:blood; D010368:Pectins / Q000494:pharmacology*; D011897:Random Allocation; D012527:Satiation / Q000187:drug effects*
chemical_list: D010191:Pancreatic Polypeptide; D010368:Pectins; D008747:Methylcellulose; D002766:Cholecystokinin