Synthesis of 7 beta-[(Z)-2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4- carboxylic acid (ceftizoxime), a new semisynthetic cephalosporin antibiotic. I. An improved method for the preparation of 7-amino-3-methylene- and 7-amino-3-hydroxycepham-4-carboxylic acid.
Kobayashi
M
M
Kato
M
M
Ueda
I
I
D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D015296:Ceftizoxime; D055598:Chemical Phenomena; D002621:Chemistry; D007769:Lactams; D008968:Molecular Conformation; D047090:beta-Lactams / Q000138:chemical synthesis*
C057018:7-amino-3-methylenecepham-4-carboxylic acid; D007769:Lactams; D047090:beta-Lactams; C057017:7-amino-3-hydroxycepham-4-carboxylic acid; D015296:Ceftizoxime; D002439:Cefotaxime