Combined linkage and segregation analysis using regressive models.
Regressive models for segregation analysis have been extended to include multivariate data and linked marker loci. The new models have been applied to data from two pedigrees segregating a gene for cardiovascular disease.
Bonney
G E
GE
Division of Biostatistics, Howard University Cancer Center, Washington, DC.
Lathrop
G M
GM
Lalouel
J M
JM
D001055:Apolipoproteins B / Q000097:blood / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006937:Hypercholesterolemia / Q000235:genetics; D006995:Hypobetalipoproteinemias / Q000235:genetics; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D010641:Phenotype; D011973:Receptors, LDL / Q000235:genetics
D001055:Apolipoproteins B; D005819:Genetic Markers; D011973:Receptors, LDL