T helper and T suppressor cells are restricted by the A and E molecules, respectively, in the F antigen system.
The role of the A and E molecules as restriction elements was examined in the F antigen system. In the mouse the only responder haplotype known to date is k, and blocking studies with a monoclonal antibody show that in vitro T-cell proliferation is restricted by the Ak molecule. The (CBA X DBA/2)F1 hybrid, which is a responder X nonresponder cross, is itself a nonresponder in terms of F-specific antibody production. Up to 10 days after priming, (CBA X DBA/2)F1 T cells exhibited an F-specific proliferative response, but this diminished rapidly at later times. This diminution could be blocked with an E-specific monoclonal antibody, suggesting that suppression is restricted by the E molecule.
Oliveira
D B
DB
Blackwell
N
N
Virchis
A E
AE
Axelrod
R A
RA
D000818:Animals; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D007108:Immune Tolerance; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000949:Histocompatibility Antigens Class II