The mosaic of colour-specific photoreceptors in the mammalian retina as defined by immunocytochemistry.
A monoclonal antibody (OS-2) produced earlier to chicken visual pigments was found to recognize a small fraction of cones in mammalian species. Recently, these cones were shown to be blue-sensitive by the method of selective photic damage. After exposing rabbits to intense blue light, characteristic morphological changes were found in cones stained by OS-2. Another monoclonal antibody (COS-1), in turn, labelled all the intact cones which remained unstained by OS-2. The complementarity of OS-2 positive and COS-1 positive cones was demonstrated in several mammalian species, including monkey and man.
Szél
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A
1st Laboratory of Electron Microscopy, Semmelweis University Medical School, Budapest, Hungary.
Röhlich
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P
D000818:Animals; D000911:Antibodies, Monoclonal; D002417:Cattle; D004285:Dogs; D005260:Female; D000882:Haplorhini; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010786:Photoreceptor Cells / Q000032:analysis*; D011817:Rabbits; D012168:Retinal Pigments / Q000032:analysis*; D012377:Rodentia; D013552:Swine
D000911:Antibodies, Monoclonal; D012168:Retinal Pigments