Effects of oral contraceptive steroids on aortic collagen, elastin and cholesterol levels in iron-deficient rats.
The effects of oral contraceptive steroids (OCS) and/or Fe deficiency on aortic collagen, elastin and cholesterol levels in female rats were investigated for 12 months. The Fe deficiency did not affect the aortic collagen and cholesterol levels, but it had a tendency to decrease the elastin content. The administration of OCS tended to increase the collagen content, while it did to lower the elastin levels. The combination effects of OCS treatment and the Fe deficiency on the aortic components were in general similar to those of OCS or Fe-deficient anemia alone. The data suggest that chronic treatment with OCS under the Fe deficiency may not greatly alter rat cardiovascular function by modifying the aortic collagen, elastin, and cholesterol contents.
Seyama
Y
Y
Dept. of Clinical Chemistry, Hoshi College of Pharmacy.
Suzuki
K
K
Hirakawa
S
S
Kanke
Y
Y
D000747:Anemia, Hypochromic / Q000378:metabolism*; D000818:Animals; D001011:Aorta / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D004549:Elastin / Q000378:metabolism*; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains
D003278:Contraceptives, Oral, Hormonal; D003094:Collagen; D004549:Elastin; D002784:Cholesterol