title: Failure of high-dose intravenous magnesium sulfate to control myoclonic status epilepticus.
abstract: An unsuccessful attempt to terminate myoclonic status epilepticus with elevation of serum magnesium levels is described. During 3 days, serum magnesium was increased from 1.5 mEq/L to 14.2 mEq/L by continuous i.v. infusion of 3-6 g/h of magnesium sulfate. Other anticonvulsants were maintained at nearly constant levels. Cerebrospinal fluid magnesium was 3.5 mEq/L during the infusion. Despite magnesium-related neuromuscular blockade and accompanying cessation of visible myoclonus, the electroencephalogram revealed ongoing blunted sharp-wave activity at the baseline frequency. Transient complications of the infusion included prolongation of the PR interval on the electrocardiogram, hypomotility of the gastrointestinal tract, and peripheral muscle flaccidity, all of which resolved within 24 h of return to normal serum magnesium levels. These results suggest that the therapeutic role of magnesium in myoclonic status epilepticus is limited.
authors.affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
authors.forename: R S
authors.initials: RS
authors.lastname: Fisher
authors.forename: P W
authors.initials: PW
authors.lastname: Kaplan
authors.forename: A
authors.initials: A
authors.lastname: Krumholz
authors.forename: R P
authors.initials: RP
authors.lastname: Lesser
authors.forename: S A
authors.initials: SA
authors.lastname: Rosen
authors.forename: M R
authors.initials: MR
authors.lastname: Wolff
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000097:blood / Q000188:drug therapy; D006801:Humans; D007262:Infusions, Intravenous; D008278:Magnesium Sulfate / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D008297:Male; D013226:Status Epilepticus / Q000097:blood / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants; D008278:Magnesium Sulfate