[Metamizol-caffeine elimination in females with increased serum aminotransferase activities treated with steroidal oral contraceptives].
The elimination of caffeine from the plasma and the excretion of the major metabolites of metamizol (AnalginR) in the urine was studied in 25 women on long-term oral steroid contraceptives. Both tests allowed to draw conclusions about metabolic liver function. A steroid-induced delay of the elimination of caffeine in clinically healthy women with/without serologic elevation of aminotransferase activities was demonstrated. --We regard this as the consequence of an inhibition of the cytochrome P-450-dependent poly-functional oxidases of the P-450MC type, which was produced by oral contraceptives. The differences in the elimination of metamizol were not significant.
Bergmann
M
M
Klinik für Innere Medizin, Institut für Pharmakologie und Toxikologie, Friedrich-Schiller-Universität Jena.
Splinter
F C
FC
Henschel
L
L
Balogh
A
A
Hoffmann
A
A
Klinger
G
G
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D000632:Aminopyrine / Q000031:analogs & derivatives*; D001219:Aspartate Aminotransferases / Q000097:blood*; D002110:Caffeine / Q000493:pharmacokinetics*; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage / Q000009:adverse effects*; D004177:Dipyrone / Q000493:pharmacokinetics*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D008111:Liver Function Tests; D008134:Long-Term Care; D008657:Metabolic Clearance Rate / Q000187:drug effects
D003278:Contraceptives, Oral, Hormonal; D000632:Aminopyrine; D002110:Caffeine; D004177:Dipyrone; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Die Metamizol-Coffein-Elimination bei Frauen mit erhöhten Aminotransferase-Aktivitäten im Serum unter steroidalen oralen Kontrazeptiva.