[The role of ADP-ribosylation processes in the repair of cytogenetic damage in mammalian cells].
Nicotinamide (NA) was shown to increase the yield of chromosome aberrations in irradiated Chinese hamster cells. The effect was observed with all doses used (1-4 Gy) and in all phases of the cell cycle; it was maximum as cells transferred from S to G1 phase. The modification of radiation-induced aberrations was more pronounced in the chromatid deletions and in exchanges. The combined action of NA and caffeine showed a synergism. It is assumed that NA inhibits reparation in a different way than caffeine does.
Aptikaeva
G F
GF
Ganassi
E E
EE
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002453:Cell Cycle; D002460:Cell Line; D002869:Chromosome Aberrations / Q000187:drug effects* / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000166:cytology / Q000648:ultrastructure; D009536:Niacinamide / Q000494:pharmacology*; D009702:Nucleoside Diphosphate Sugars / Q000037:antagonists & inhibitors*; D011064:Poly Adenosine Diphosphate Ribose / Q000037:antagonists & inhibitors*; D011836:Radiation Tolerance
D009702:Nucleoside Diphosphate Sugars; D009536:Niacinamide; D011064:Poly Adenosine Diphosphate Ribose; D002110:Caffeine
Ob uchastii protsessov ADF-ribozilirovaniia v reparatsii tsitogeneticheskogo povrezhdeniia kletok mlekopitaiushchikh.