title: Isotypy of serum monoclonal immunoglobulins in human immunodeficiency virus-infected adults.
abstract: The classes, subclasses and light chain types of 78 serum monoclonal immunoglobulins (MoIg) from adult patients affected with various clinical forms of human immunodeficiency virus (HIV) infection were studied by a sensitive Western blot technique. The incidence of MoIg-containing sera was 26% in a systematic study. Most of these sera contained several (up to eight) detectable MoIg. These MoIg were IgG (91%) and IgM (9%) with a predominance of light chains of the lambda type (kappa:lambda ratio 0.6). The subclass distribution of monoclonal IgG was strikingly different from that observed in myeloma; much less IgG1 and much more IgG3 and IgG4.
authors.affiliation: Laboratory of Immunology and Immunopathology (CNRS UA 1172), Poitiers University Hospital, France.
authors.forename: S
authors.initials: S
authors.lastname: Briault
authors.forename: M
authors.initials: M
authors.lastname: Courtois-Capella
authors.forename: F
authors.initials: F
authors.lastname: Duarte
authors.forename: P
authors.initials: P
authors.lastname: Aucouturier
authors.forename: J L
authors.initials: JL
authors.lastname: Preud'Homme
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D015153:Blotting, Western; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007132:Immunoglobulin Isotypes / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D009101:Multiple Myeloma / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains