Adoptive transfer of transplantation tolerance in the H-2 compatible mouse system CBA/C3H. Transfer of lymphocyte subpopulations into irradiated and non-irradiated mice.
Transfer of neonatally induced tolerance in the H-2 compatible CBA/C3H strain combination is possible with different efficiency by injection of adherent and non-adherent spleen cells, unseparated spleen cells and lymph node cells from C3H-tolerant CBA mice into sublethal irradiated CBA mice. The most efficient cell populations are adherent spleen cells and lymph node cells. Successful transfer of transplantation tolerance is not possible to non-irradiated mice. The adherent fraction of spleen cells and lymph node cells contains a suppressor cell population responsible for transplantation tolerance against non-H-2 antigens. The induced transplantation tolerance is not due to a chimaeric state of C3H-tolerant CBA mice.
Siegl
E
E
Brock
J
J
Schulze
H A
HA
D000818:Animals; D002448:Cell Adhesion; D006085:Graft Survival; D006183:H-2 Antigens; D006648:Histocompatibility; D007108:Immune Tolerance; D007116:Immunization, Passive; D008198:Lymph Nodes / Q000166:cytology; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000145:classification; D051379:Mice; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D011828:Radiation Chimera; D013154:Spleen / Q000166:cytology
D006183:H-2 Antigens