The aminopyrine breath test for the evaluation of liver function in alcoholic patients: drug pharmacokinetics and environmental factors.
Drug pharmacokinetics and environmental factors contribute to the selection of an ideal drug substrate for the determination of liver function via the carbon dioxide breath test. An ideal drug should be rapidly absorbed, and have an hepatic extraction ratio between 0.2 and 0.5. Its metabolism should not be induced by ethanol or be affected by cigarette smoking. The relative promise of caffeine and methacetin are compared to aminopyrine.
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Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892.
D000081:Acetamides / Q000493:pharmacokinetics; D000632:Aminopyrine / Q000493:pharmacokinetics; D002110:Caffeine / Q000493:pharmacokinetics; D002245:Carbon Dioxide / Q000032:analysis; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000175:diagnosis*; D008111:Liver Function Tests; D012907:Smoking / Q000503:physiopathology
D000081:Acetamides; D000632:Aminopyrine; C035495:methacetin; D002245:Carbon Dioxide; D002110:Caffeine; D000431:Ethanol