Bone and muscle atrophy with suspension of the rat.
A modification of the Morey tail suspension model was used to determine atrophic responses of rat bone and muscle with 14-90 days unloading of the hindlimbs. Bone uptake of methylene diphosphonate followed a phasic pattern similar to changes in bone formation rate in immobilized dogs and rats. Increased uptake at 60 days (P = 0.01, femur) indicated an increased bone metabolism. Regional densitometry demonstrated a preferential loss of bone mineral in the trabecular mass (P = 0.02) at 30 days and in the cortical shaft by 90 days (P = 0.03). Maximal muscle atrophy occurred within 14-30 days. The gastrocnemius was less severely affected by suspension than by immobilization techniques, whereas the soleus atrophied (by weight) similarly, suggesting that muscle atrophy in the suspension model is distinctly different from immobilization atrophy. One significant response of skeletal muscle to suspension was an altered blood distribution. Muscle blood distribution changes reflect the hypodynamic state of muscle that continues to contract but probably at an altered rate in response to altered functional demands.
LeBlanc
A
A
Marsh
C
C
Evans
H
H
Johnson
P
P
Schneider
V
V
Jhingran
S
S
D000818:Animals; D001284:Atrophy; D001846:Bone Development; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology*; D003720:Densitometry; D004164:Diphosphonates; D006112:Gravitation; D007103:Immobilization; D008903:Minerals / Q000378:metabolism; D009132:Muscles / Q000098:blood supply / Q000378:metabolism; D009133:Muscular Atrophy / Q000209:etiology* / Q000378:metabolism; D051381:Rats; D012039:Regional Blood Flow; D013667:Technetium; D013669:Technetium Tc 99m Medronate; D013997:Time Factors; D014893:Weightlessness / Q000009:adverse effects
D004164:Diphosphonates; D008903:Minerals; D013667:Technetium; D013669:Technetium Tc 99m Medronate