Discordant interleukin 2 production in monozygotic twins concordant for systemic lupus erythematosus.
We present data from monozygotic twins concordant for SLE. IL-2 production by peripheral blood mononuclear cells from the patients, when they were discordant for SLE activity, were measured employing cellular mixing experiments. Macrophages from active SLE had a suppressive effect on IL-2 production. Furthermore, SLE T cells appeared to have a defect in IL-2 production irrespective of disease activity. These defects might play an important role in the disordered immunoregulation in SLE.
Sato
K
K
Division of Clinical Immunology, Tokyo Women's Medical College, Japan.
Miyasaka
N
N
Yamaoka
K
K
Yamada
T
T
Nishido
T
T
Okuda
M
M
Nishioka
K
K
D000328:Adult; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D014430:Twins, Monozygotic
D007376:Interleukin-2; D015850:Interleukin-6