title: The effects of calcitonin on idiopathic nephrolithiasis. Evidence of bone involvement in fasting hypercalciuria.
abstract: This study was performed to evaluate the antihypercalciuric effect of calcitonin (CT), a potent inhibitor of bone osteoclastic activity, on idiopathic hypercalciuria (IH). Forty-two stone formers were studied: 18 suffered from fasting hypercalciuria (FH), 12 from nonfasting hypercalciuria (NFH) and 12 were normocalciuric stone formers (NSF). All patients received CT, 25 U/day sc for a period of 15 days. CT caused a statistically significant drop in urine calcium, phosphorus and hydroxyproline (OH-proline) excretion in FH patients and a concomitant increase in serum PTH levels. In this group the percentage variation (D%) of urine calcium decrease was linearly correlated with D% decrease in urine OH-proline. These results support the hypothesis that pathological bone reabsorption might be involved in the genesis of FH.
authors.affiliation: Istituto di Clinica Medica I, University of Perugia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Filipponi
authors.forename: C
authors.initials: C
authors.lastname: Mannarelli
authors.forename: G
authors.initials: G
authors.lastname: Gubbiotti
authors.forename: A
authors.initials: A
authors.lastname: Blass
authors.forename: I
authors.initials: I
authors.lastname: Moretti
authors.forename: S
authors.initials: S
authors.lastname: Tini
authors.forename: N
authors.initials: N
authors.lastname: Giuseppetti
authors.forename: S
authors.initials: S
authors.lastname: Ballanti
authors.forename: P
authors.initials: P
authors.lastname: Morucci
mesh_terms: D002116:Calcitonin / Q000627:therapeutic use*; D002118:Calcium / Q000652:urine*; D005215:Fasting; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D007669:Kidney Calculi / Q000097:blood / Q000188:drug therapy / Q000652:urine*; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000652:urine
chemical_list: D010281:Parathyroid Hormone; D010758:Phosphorus; D002116:Calcitonin; D006909:Hydroxyproline; D002118:Calcium