Effects of zinc and EDTA on tissue cadmium in various smooth muscles in rabbit and guinea-pig.
1. The effects of zinc (Zn2+) and ethylenediaminetetra-acetic acid (EDTA) on tissue cadmium (Cd2+) were investigated in the smooth muscles of rabbit trachea, taenia coli, aorta and guinea-pig taenia coli. 2. After an Cd uptake in high-K2+ solution, samples were rinsed with cold high-K2+, cold Zn2+ or cold EDTA solution without Cd2+ and the results were quantitatively different from each other. 3. Concentration-response curves were obtained with each treatment of cold solution. 4. It is suggested that tissue Cd2+ can be divided into 3 fractions in the surface membrane and there is another fraction in cellular space.
Ueda
F
F
Department of Veterinary Public Health, Nippon Veterinary and Zootechnical College, Tokyo, Japan.
Nagata
M
M
Nagata
T
T
Shimazaki
Y
Y
D000818:Animals; D002104:Cadmium / Q000378:metabolism*; D003106:Colon / Q000187:drug effects / Q000378:metabolism; D004492:Edetic Acid / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D011817:Rabbits; D015032:Zinc / Q000378:metabolism / Q000494:pharmacology*
D002104:Cadmium; D004492:Edetic Acid; D015032:Zinc