Presence of antibody to A- and B-transferases in minor incompatible bone marrow transplant.
The contribution of the bone marrow to plasma A- or B-transferase activities has been studied in patients who underwent incompatible bone marrow transplantation (BMT). As deduced from major incompatibility (group O recipient/A donor), the contribution of the marrow to these plasma activities was c. 5-10% of the total activity. In cases of minor incompatible transplants (A recipient/O donor), normal plasma activity was present in two patients, while no activity was found in a further two in whom a potent antitransferase was detected. The antibody inhibited both A- and B-transferase activities to a high titre. The patients in whom this antibody arose exhibited severe graft-versus-host disease.
Barbolla
L
L
Clínica Puerta de Hierro, Universidad Autónoma de Madrid, Spain.
Mojena
M
M
Boscá
L
L
D000017:ABO Blood-Group System / Q000276:immunology; D000906:Antibodies / Q000032:analysis*; D001787:Blood Group Incompatibility / Q000201:enzymology / Q000276:immunology*; D016026:Bone Marrow Transplantation; D005700:Galactosyltransferases / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D017350:N-Acetylgalactosaminyltransferases; D013997:Time Factors
D000017:ABO Blood-Group System; D000906:Antibodies; D005700:Galactosyltransferases; D017350:N-Acetylgalactosaminyltransferases; C003742:UDPgalactosamine-galactose acetylgalactosaminyltransferase; C023155:blood-group-substance alpha-D-galactosyltransferase