title: Spleen cell populations in normal and tumor-bearing hamsters.
abstract: Spleen cell subpopulations from normal and tumor-bearing hamsters (TBH) were quantified using Petri dishes coated with specific antibodies, and by flow cytometric immunofluorescence analysis. The relative numbers of T cells (Thy + cells) decreased, by both methods, as a function of tumor growth, while the number of B cells (bearing surface Ig) increased. Cells without T or B markers (null cells) were more numerous in the spleen of TBH and a large number of them expressed the receptor for the Fc fragment of IgG. Splenic cells were also sorted according to their light-scattering properties, and electron microscopic analysis was performed on the sorted fractions. It showed the presence of secreting plasmocytes and activated macrophages in the spleen of TBH.
authors.forename: G
authors.initials: G
authors.lastname: Merdrignac
authors.forename: H
authors.initials: H
authors.lastname: Haddada
authors.forename: C
authors.initials: C
authors.lastname: De Vaux Saint Cyr
authors.forename: B
authors.initials: B
authors.lastname: Genetet
mesh_terms: D000818:Animals; D002452:Cell Count; D006224:Cricetinae; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology*; D011961:Receptors, Fc; D017452:Receptors, IgG; D013154:Spleen / Q000166:cytology* / Q000276:immunology
chemical_list: D011961:Receptors, Fc; D017452:Receptors, IgG