Potential radiopharmaceuticals for the diagnosis of biliary atresia and neonatal hepatitis: EHPG and HBED chelates of 67Ga and 111In.
Radiopharmaceuticals suitable for use in cases where delayed excretion of hepatobiliary tracer can occur, were formulated from indium-111 and gallium-67 and the chelating agents N,N'-ethylene-bis-[o-hydroxy-phenylglycine], (EHPG) and N,N'-bis-[2-hydroxybenzyl] ethylenediamine-N,N'-diacetic acid, (HBED). The hepatobiliary excretion of these 67Ga and 111In chelates was optimised by using chelators which had substituents in the phenolic ring; halogen substituents imparted the most favourable characteristics.
Hunt
F C
FC
Australian Nuclear Science and Technology Organisation, Lucas Heights Research Laboratories, Menai, NSW.
D000818:Animals; D001656:Biliary Atresia / Q000000981:diagnostic imaging*; D002614:Chelating Agents; D004492:Edetic Acid / Q000031:analogs & derivatives*; D005029:Ethylenediamines; D005260:Female; D005710:Gallium Radioisotopes; D006505:Hepatitis / Q000151:congenital* / Q000000981:diagnostic imaging; D006801:Humans; D007205:Indium Radioisotopes; D007231:Infant, Newborn; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011817:Rabbits; D011877:Radionuclide Imaging
D002614:Chelating Agents; D005029:Ethylenediamines; D005710:Gallium Radioisotopes; D007205:Indium Radioisotopes; C011813:ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid); C037740:N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid; D004492:Edetic Acid