Comparison of antiepileptic action of valproate and ethosuximide in adult and immature rats.
The antiepileptic action of ethosuximide and valproate was studied in immature rats in the pentetrazole (PTZ) model. Valproate antagonized the effect of PTZ in rats of all ages, while ethosuximide was effective only in rats of 25 or more days of age: in 18 day old rats it modified the PTZ seizure pattern and was ineffective in younger animals or only slightly affected the PTZ seizure pattern. Similarly, the ECoG studies have shown that valproate antagonizes PTZ action at all ages, while ethosuximide only in mature rats.
Mares
P
P
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
Velisék
L
L
D000818:Animals; D004569:Electroencephalography; D005013:Ethosuximide / Q000627:therapeutic use*; D010433:Pentylenetetrazole; D051381:Rats; D012640:Seizures / Q000188:drug therapy* / Q000503:physiopathology; D014635:Valproic Acid / Q000627:therapeutic use*
D005013:Ethosuximide; D014635:Valproic Acid; D010433:Pentylenetetrazole