Cell growth and division in relation to differentiation of mouse erythroleukemia cells.
Addition of certain inhibitors of RNA or protein synthesis to cells cultured in 20% serum, but not 5% serum, induces the differentiation of mouse erythroleukemia cells. Differentiation also was induced by culture at a low serum concentration (0.1%) to starve cells to quiescence, then inducing division by exposing cells to either of two high-pH regimes.
Daniels
R
R
Department of Biological Sciences, State University of New York, Buffalo 14260.
Gerbracht
T
T
Flickinger
R A
RA
D000409:Alanine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002460:Cell Line; D003513:Cycloheximide / Q000494:pharmacology; D005622:Friend murine leukemia virus; D006863:Hydrogen-Ion Concentration; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology*; D051379:Mice; D009173:Mycophenolic Acid / Q000494:pharmacology; D014176:Protein Biosynthesis; D012335:RNA, Ribosomal / Q000096:biosynthesis
D012335:RNA, Ribosomal; C000082:alanosine; D003513:Cycloheximide; D009173:Mycophenolic Acid; D000409:Alanine