title: Cellular immune functions in patients with primary hyperparathyroidism: effects of histamine and cimetidine.
abstract: The possibility of a link between parathyroid hyperfunction and cellular immune functions was studied in primary hyperparathyroid (1 degree HP) patients. The effect of cimetidine on lymphocyte functions in 1 degree HP patients and control subjects was also investigated. Histamine-induced suppressor activity of lymphocytes from 1 degree HP patients was significantly greater than that of controls. Cimetidine addition to both normal and 1 degree HP lymphocyte cultures abolished histamine-induced suppression. In vivo administration of cimetidine, while ineffective towards normal lymphocytes, depressed phytohemagglutinin stimulation of 1 degree HP lymphocytes, indicating possible immunological damage caused by this drug, which is frequently used in the treatment of patients with 1 degree HP.
authors.forename: N
authors.initials: N
authors.lastname: Lahat
authors.forename: B
authors.initials: B
authors.lastname: Glaser
authors.forename: E
authors.initials: E
authors.lastname: Nir
authors.forename: M
authors.initials: M
authors.lastname: Rotem
authors.forename: M
authors.initials: M
authors.lastname: Sheinfeld
authors.forename: Z
authors.initials: Z
authors.lastname: Kraiem
mesh_terms: D002927:Cimetidine / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D006961:Hyperparathyroidism / Q000276:immunology*; D007111:Immunity, Cellular / Q000187:drug effects; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects
chemical_list: D010835:Phytohemagglutinins; D003208:Concanavalin A; D002927:Cimetidine; D006632:Histamine