Immunoelectron microscopical localization of immunoglobulins, secretory component and J chain in the human minor salivary glands.
Localization of IgA, secretory component (SC) and J chain was investigated immunocytochemically in minor salivary glands of the lip and palate to define the mechanism involved in the transport of immunoglobulin A (sIgA) into the saliva from the minor salivary glands. SC synthesis was detected in mucous acinar cells and ductal epithelial cells. Free SC is secreted into the saliva through secretory granules in the mucous acinar cells. Dimeric IgA containing J chain is translocated through these cells as sIgA by a SC-mediated transport mechanism involving cytoplasmic vesicles.
Sumi
Y
Y
Department of Oral Surgery, Nagoya University, Japan.
Nagura
H
H
Kaneda
T
T
Oka
T
T
D002462:Cell Membrane / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004847:Epithelial Cells; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007128:Immunoglobulin Fragments / Q000032:analysis; D007144:Immunoglobulin J-Chains / Q000032:analysis; D007150:Immunohistochemistry; D008046:Lip; D008854:Microscopy, Electron; D015388:Organelles / Q000648:ultrastructure; D010159:Palate; D012469:Salivary Glands / Q000166:cytology*; D012470:Salivary Glands, Minor / Q000166:cytology*; D012635:Secretory Component / Q000032:analysis
D007071:Immunoglobulin A, Secretory; D007128:Immunoglobulin Fragments; D007144:Immunoglobulin J-Chains; D012635:Secretory Component