title: Extracts of brewer's yeast contain GABA which enhances activation of glycogen synthetase by insulin in isolated rat hepatocytes.
abstract: Extracts of brewer's yeast have been fractionated, and the effects of fractions on the incorporation of 14C-labelled precursors into glycogen by hepatocytes have been studied. Purification of fractions which enhanced response to insulin resulted in the isolation of gamma-aminobutyric acid (GABA) which stimulated glycogen synthetase activity in the presence but not in the absence of suboptimal insulin concentrations.
authors.affiliation: Department of Biochemistry, University of Tasmania, Hobart.
authors.forename: E S
authors.initials: ES
authors.lastname: Holdsworth
authors.forename: E
authors.initials: E
authors.lastname: Neville
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005591:Chemical Fractionation; D004789:Enzyme Activation; D005215:Fasting; D005943:Gluconeogenesis; D006006:Glycogen Synthase / Q000378:metabolism*; D007328:Insulin / Q000502:physiology*; D008099:Liver / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000032:analysis*; D012588:Scintillation Counting; D012995:Solubility; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D007328:Insulin; D005680:gamma-Aminobutyric Acid; D006006:Glycogen Synthase