title: Enhanced endothelialization of Dacron grafts by external vein wrapping.
abstract: The efficacy of external vein wrapping of vascular grafts in promoting the development of a luminal endothelial surface was assessed in 12 dogs who underwent thoracoabdominal bypasses with 26-29 cm X 6-mm i.d. double-velour knitted Dacron grafts. In group I (n = 6) 6-cm segments of the grafts were wrapped with autologous jugular vein with its endothelial surface applied against the outside of the graft. In group II (n = 6) the wrap procedure was performed using abdominal wall fascia. The degree and character of graft incorporation was quantitated in all prostheses at 28 days postimplantation. Group I vein wrap prostheses demonstrated uniform endothelial surface coverage in the vein wrap area (means = 88%) that was significantly greater (P less than 0.04) than coverage in adjacent unwrapped segments (means = 48%). Group II fascial wrap grafts demonstrated variable endothelial coverage in the wrapped area (means = 48%) that was consistently less than in adjacent unwrapped portions (means = 62%), and significantly less than vein wrap sections of group I animals (P less than 0.04). No significant differences existed in endothelial coverage of unwrapped regions of group I and II grafts. This investigation documented that wrapping knitted Dacron grafts with vein enhanced endothelialization of their luminal surface.
authors.forename: L M
authors.initials: LM
authors.lastname: Graham
authors.forename: K A
authors.initials: KA
authors.lastname: Harrell
authors.forename: R L
authors.initials: RL
authors.lastname: Sell
authors.forename: J W
authors.initials: JW
authors.lastname: Crudup
authors.forename: W E
authors.initials: WE
authors.lastname: Burkel
authors.forename: J C
authors.initials: JC
authors.lastname: Stanley
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D001013:Aorta, Thoracic / Q000601:surgery; D001807:Blood Vessel Prosthesis; D004285:Dogs; D004727:Endothelium / Q000166:cytology / Q000502:physiology / Q000648:ultrastructure; D006083:Graft Occlusion, Vascular; D008855:Microscopy, Electron, Scanning; D011093:Polyethylene Terephthalates; D013927:Thrombosis / Q000517:prevention & control; D014680:Veins / Q000502:physiology*
chemical_list: D011093:Polyethylene Terephthalates