title: Cell cycle-related expression of surface antigens on myelomonocytic leukemia cells.
abstract: We investigated the relationship between the expression of surface antigens and the cell cycle phase in leukemic cells from cell lines and one patient using two-color flow cytometry, in order to determine the reason for the uneven expression of some markers which frequently leads to equivocal results as to leukemic phenotyping. As a result, it was demonstrated that monocyte-related differentiation markers, including I2, My4, Mo1 and Mo2, on monocytoid leukemic cells are preferentially expressed at the G0/G1 phase. Consequently, it is expected that the positivities for such markers vary with the proliferation status of the leukemic cells.
authors.affiliation: Department of Pediatrics, Tokyo Medical and Dental University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takase
authors.forename: H
authors.initials: H
authors.lastname: Okawa
authors.forename: K
authors.initials: K
authors.lastname: Minato
authors.forename: J
authors.initials: J
authors.lastname: Yata
mesh_terms: D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D001853:Bone Marrow / Q000473:pathology; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D002460:Cell Line; D006801:Humans; D007399:Interphase; D015479:Leukemia, Myelomonocytic, Acute / Q000097:blood / Q000276:immunology* / Q000473:pathology; D010641:Phenotype
chemical_list: D015214:Antigens, Differentiation, Myelomonocytic; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D014408:Biomarkers, Tumor