Action of metal chelators on lipoxygenases, cyclooxygenase and on inflammation-induced vasodepression.
Metal complexing agents could exert antiinflammatory activity by inhibition of oxygen radical production, by inhibition of eicosanoid synthesis and by inhibition of metalloenzymes. We found a moderate antiedema activity of the iron (II)/iron (III)-chelator combination, o-phenanthroline/desferrioxamine, which could refer to an involvement of iron ions in the inflammatory reaction. The newly synthetized complexing agent ethylene-diimino-dibutyric acid caused weak antiedema and antivasodepressor effects which remain to be explained. Altogether, the in vivo effects of the metal chelators were rather weak. In vitro, only desferrioxamine produced a remarkable inhibition of two lipoxygenases.
Hirschelmann
R
R
Wissenschaftsbereich Pharmakologie, Martin-Luther-Universität Halle-Wittenberg, DDR.
Kuhn
C
C
Zarnack
S
S
Funke
T
T
Bekemeier
H
H
Giessler
A J
AJ
Phuoc
L T
LT
Bŏge
A
A
D000818:Animals; D001168:Arthritis / Q000503:physiopathology*; D001169:Arthritis, Experimental / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D002614:Chelating Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004487:Edema / Q000517:prevention & control*; D007249:Inflammation / Q000503:physiopathology / Q000517:prevention & control; D007502:Iron Chelating Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008084:Lipoxygenase / Q000378:metabolism*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D051381:Rats; D014655:Vascular Resistance / Q000187:drug effects
D002614:Chelating Agents; D007502:Iron Chelating Agents; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases