[The heterozygosity for the biochemical and immunological markers of genes and the variability of morphophysiological traits in man].
The relationship between heterozygosity of 9 biochemical and 5 blood group loci and variability of body length and age of menarche were studied in 467 women and 336 men from Moscow population. High and low levels of individual heterozygosity were shown in men to be associated with the maximal values of the coefficient of variation (CV) of body length, while in women strong positive correlation between the CV of body length and individual heterozygosity was demonstrated. The highest level of heterozygosity was revealed in medium-height men and low-height women. Highly heterozygous women were characterized either by early or by late age of menarche; early onset of menarche causes growth retardation. Positive correlation between the CV of body length and heterozygosity in women is due to the accumulation of low-height individuals having early age of menarche. The results are discussed in terms of Lerner's concept of genetic homeostasis. It is concluded that an average level of heterozygosity is optimal for a population.
Dubrova
Iu E
IuE
Altukhov
Iu P
IuP
Kucher
A N
AN
Ikramov
K M
KM
D000328:Adult; D001827:Body Height; D005260:Female; D005796:Genes; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008572:Menarche / Q000235:genetics; D009031:Moscow; D012727:Sex Characteristics; D014505:Urban Population
D005819:Genetic Markers
Geterozigotnost' po biokhimicheskim i immunologicheskim markeram genov i izmenchivost' morfofiziologicheskikh priznakov u cheloveka.