The metabolism and pharmacokinetics of fleroxacin in healthy subjects.
A 400 mg dose of fleroxacin was administered orally to six healthy male volunteers. Concentrations of fleroxacin and the N-demethyl and N-oxide metabolites were determined in serum and urine by HPLC. The serum metabolite levels were negligible. The N-oxide metabolite was measured in the serum of five subjects but did not exceed 4% of the corresponding fleroxacin level. N-demethyl fleroxacin was not detected (less than 0.1 mg/l). The urinary recovery of fleroxacin was 49.5% over 72 h; the N-demethyl and N-oxide metabolites accounted for 6.9% and 5.7%, respectively, of the administered dose.
Griggs
D J
DJ
Department of Microbiology, Dudley Road Hospital, Birmingham, UK.
Wise
R
R
Kirkpatrick
B
B
Ashby
J P
JP
D000890:Anti-Infective Agents / Q000378:metabolism* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics; D016576:Fleroxacin; D006801:Humans; D008297:Male
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D016576:Fleroxacin