title: Reduced alpha-2-antiplasmin levels in the nephrotic syndrome.
abstract: Venous and arterial thromboembolism frequently complicate the nephrotic syndrome. Increased platelet aggregation, high levels of fibrinogen and other procoagulants, and depressed levels of antithrombin III and plasminogen are commonly cited as reasons. Less attention has been paid to changes in the hemostatic system which might protect against thrombosis. We found a high frequency of reduced alpha 2-antiplasmin levels in 40 patients with nephrotic syndrome, correlating with serum albumin and with antithrombin III levels. Since alpha 2-antiplasmin is a major determinant of the sensitivity of fibrin thrombi to lysis, and since reduced levels would be expected to promote fibrinolysis, we conclude that in many patients with nephrotic syndrome depressed antiplasmin levels may help reduce the risk of thrombosis posed by diminished antithrombin III levels.
authors.forename: R B
authors.initials: RB
authors.lastname: Francis
authors.forename: R M
authors.initials: RM
authors.lastname: Sandler
authors.forename: D
authors.initials: D
authors.lastname: Levitan
authors.forename: E I
authors.initials: EI
authors.lastname: Feinstein
authors.forename: S G
authors.initials: SG
authors.lastname: Massry
authors.forename: D I
authors.initials: DI
authors.lastname: Feinstein
mesh_terms: D000990:Antithrombin III / Q000032:analysis; D006487:Hemostasis; D006801:Humans; D009404:Nephrotic Syndrome / Q000097:blood* / Q000150:complications; D010958:Plasminogen / Q000032:analysis; D010978:Platelet Factor 4 / Q000032:analysis; D012709:Serum Albumin / Q000032:analysis; D013923:Thromboembolism / Q000209:etiology; D000979:alpha-2-Antiplasmin / Q000032:analysis*; D001620:beta-Thromboglobulin / Q000032:analysis
chemical_list: D012709:Serum Albumin; D000979:alpha-2-Antiplasmin; D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; D000990:Antithrombin III; D010958:Plasminogen