Alginate production by the mucoid Pseudomonas aeruginosa associated with cystic fibrosis.
Pseudomonas aeruginosa is an important human pathogen. Mucoid, alginate producing strains are specifically selected in the lungs of patients with cystic fibrosis. Advances in our understanding of the biochemistry, genetics and molecular biology of alginate synthesis in these organisms is discussed.
Gill
J F
JF
Department of Microbiology and Immunology, University of Illinois Health Sciences Center, Chicago 60612.
Deretic
V
V
Chakrabarty
A M
AM
D000464:Alginates / Q000378:metabolism*; D003550:Cystic Fibrosis / Q000150:complications / Q000382:microbiology*; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006801:Humans; D011014:Pneumonia / Q000150:complications / Q000382:microbiology; D011552:Pseudomonas Infections / Q000150:complications / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000378:metabolism*
D000464:Alginates; D006603:Hexuronic Acids; D020723:Glucuronic Acid