Altered body temperature of rabbits after central injection of beta-endorphin and other peptides.
After injection of 5 micrograms into a lateral cerebral ventricle, 6 of 12 peptides induced mean changes of 0.3 degree C or more in rectal temperature of rabbits. When beta-endorphin was studied further with 1.25-5 micrograms in 10, 23 and 30 degrees C environments, it induced dose-related hypothermia in the cold, hyperthermia in the heat and progressively smaller increases in body temperature with increasing doses at 23 degrees C.
Glyn-Ballinger
J R
JR
Clark
W G
WG
Lipton
J M
JM
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D004723:Endorphins / Q000494:pharmacology*; D007032:Hypothalamus, Anterior / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D011301:Preoptic Area / Q000187:drug effects; D011817:Rabbits; D001615:beta-Endorphin
D004723:Endorphins; D009419:Nerve Tissue Proteins; D001615:beta-Endorphin