[Studies on induction mechanism of ossification of the posterior longitudinal ligament of the spine--especially on the cultured cells from the human spinal ligament].
To determine the mechanism of ossification of the posterior longitudinal ligament (OPLL) of the spine using cultured cells derived from the human spinal ligament, the ossification group and the non-ossification group were compared morphologically and biochemically. The results are as follows: 1) There is a difference in the characteristics of the two groups. The non-ossification group consists chiefly of fibroblast-like cells, while the ossification group consists chiefly of osteogenic un-differentiated mesenchymal cells. 2) In the ossification group, the posterior longitudinal ligament is composed of high osteogenic potential cells, with a resulting general tendency of systemic ossification. This systemic ligamentous ossification factor is a primary cause of OPLL. When localized anatomical stress and/or abnormalities of hormone and bone metabolism stimulate this ligament which is in a high osteogenic activity, this may result in initial ossification which may develop into the pathological OPLL.
Ishida
Y
Y
Department of Orthopedic Surgery, Yamaguchi University School of Medicine, Japan.
D000328:Adult; D001842:Bone and Bones / Q000378:metabolism; D002454:Cell Differentiation; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008022:Ligaments / Q000166:cytology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000209:etiology / Q000473:pathology*; D010006:Osteoblasts / Q000166:cytology; D010281:Parathyroid Hormone / Q000378:metabolism; D013131:Spine
D010281:Parathyroid Hormone