Trypanosoma cruzi: histochemical characterization of parasitized skeletal muscle fibers.
C57B1/6 mice were infected with Brasil strain Trypanosoma cruzi trypomastigotes. The leg muscles of the mice were serial-sectioned with a cryostat, and individual fibers were classified histochemically as type I or type II on the basis of succinic dehydrogenase or adenosine triphosphatase activity. Although markedly more type II fibers were present in the leg muscles, the percentage of infected type I fibers was nearly five-fold higher than type II. This is the first demonstration of a preferential in vivo distribution of T. cruzi in muscle fibers based upon muscle type.
Teixeira
M L
ML
Dvorak
J A
JA
D000251:Adenosine Triphosphatases / Q000032:analysis; D000818:Animals; D002417:Cattle; D014355:Chagas Disease / Q000469:parasitology; D005260:Female; D006651:Histocytochemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009132:Muscles / Q000201:enzymology / Q000469:parasitology*; D013385:Succinate Dehydrogenase / Q000032:analysis; D014349:Trypanosoma cruzi / Q000166:cytology / Q000254:growth & development*
D013385:Succinate Dehydrogenase; D000251:Adenosine Triphosphatases