Cross-linking of membrane IgM on B CLL cells.
We report here the study of early events following surface Ig cross-linking such as Ca2+ mobilization and IP3 generation, in chronic lymphocytic leukemia (CLL) B cells. Those leukemic populations were previously shown to be frozen at different stages of activation with unique requirements for proliferation. The study reported here disclosed 3 patterns of response in terms of Ca2+ mobilization and proliferation. These results are interpreted in terms of differential anti-mu signalling on B cells at different stages of activation.
Grillot-Courvalin
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Laboratory of Immunochemistry and Immunopathology, INSERM U108, Paris, France.
Hivroz
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Brouet
J C
JC
D000888:Antibodies, Anti-Idiotypic / Q000502:physiology; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D003432:Cross-Linking Reagents; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology / Q000378:metabolism* / Q000502:physiology; D007148:Immunoglobulin mu-Chains / Q000276:immunology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology / Q000378:metabolism*; D008213:Lymphocyte Activation; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*
D000888:Antibodies, Anti-Idiotypic; D003432:Cross-Linking Reagents; D007075:Immunoglobulin M; D007148:Immunoglobulin mu-Chains; D011947:Receptors, Antigen, B-Cell; C044203:anti-IgM