title: Fragile sites and neuroblastoma: fragile site at 1p13.1 and other points on lymphocyte chromosomes from patients and family members.
abstract: Fragile sites on lymphocyte chromosomes of 20 patients with neuroblastoma of different clinical stages and histologic differentiation were studied. A hitherto unknown break in the band p13.1 of chromosome #1 was found in a frequency of 3%-15% in nine cases. The same phenomenon was observed in three members of a neuroblastoma family. In another instance, this fragile site was also seen in the mother of a patient. Fragile sites were expressed when cells were cultured in folate-deprived medium and could be slightly enhanced in frequency by aphidicolin. Additional aphidicolin induced possible fragile sites hitherto unknown or not yet accepted by the HGM 8 were detected.
authors.affiliation: Kinderpoliklinik, University of Giessen, West Germany.
authors.forename: B
authors.initials: B
authors.lastname: Rudolph
authors.forename: J
authors.initials: J
authors.lastname: Harbott
authors.forename: F
authors.initials: F
authors.lastname: Lampert
mesh_terms: D002675:Child, Preschool; D002871:Chromosome Banding; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002878:Chromosomes, Human, Pair 1; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D009447:Neuroblastoma / Q000235:genetics*; D010375:Pedigree
chemical_list: D005819:Genetic Markers