Study of platelet-associated-immunoglobulins in lymphoproliferative disorders.
In the development of thrombocytopenia in patients with lymphoproliferative disorders immunological factors may play the decisive role. Platelet-associated immunoglobulins were investigated by anti-human IgG and anti-human IgM-coated polyacrylamide beads ("Immunobeads") with light microscopy. Among the 65 patients studied 19 had thrombocytopenia and four of them had an increased number of platelet-immunobead rosettes. In four cases from the group of patients with normal platelet count this phenomenon was also demonstrated. The platelet-associated immunoglobulin was IgG except of one case in which it was IgM. Studying of platelet-associated immunoglobulins might have significance first of all in the choice of the most adequate therapy.
Pecze
K
K
Telek
B
B
Kiss
A
A
Rak
K
K
D001792:Blood Platelets / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D008232:Lymphoproliferative Disorders / Q000276:immunology*; D010976:Platelet Count; D012397:Rosette Formation; D013921:Thrombocytopenia / Q000276:immunology
D007075:Immunoglobulin M; D007136:Immunoglobulins