title: The presence of cyclosporine in body tissues and fluids during pregnancy.
abstract: A term pregnancy, labor, and delivery is reported in a cyclosporine- and prednisone-treated female cadaveric renal allograft recipient. A male child, small for gestational age at 2370 g, was born at 38 weeks of gestation with neither congenital anomalies nor nephrotoxicity or hepatotoxicity. Cyclosporine (CSA) concentrations as determined by a radioimmunoassay are reported in maternal and fetal tissues. CSA is present in the fetal circulation during gestation at similar concentrations to those in the mother. Fetal serum at birth displayed 25% suppression of a third-party mixed lymphocyte culture (MLC) compared with control incubations. CSA was present in maternal breast milk; therefore, breastfeeding of children by CSA-treated mothers should be avoided.
authors.forename: S M
authors.initials: SM
authors.lastname: Flechner
authors.forename: A R
authors.initials: AR
authors.lastname: Katz
authors.forename: A J
authors.initials: AJ
authors.lastname: Rogers
authors.forename: C
authors.initials: C
authors.lastname: Van Buren
authors.forename: B D
authors.initials: BD
authors.lastname: Kahan
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D003524:Cyclosporins / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D016030:Kidney Transplantation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D008895:Milk, Human / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism; D007690:Polycystic Kidney Diseases / Q000601:surgery; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000276:immunology
chemical_list: D003524:Cyclosporins