title: Evaluation of tiamulin for treatment of mycoplasmal pneumonia in swine.
abstract: During 3 trials, using affected pigs of various ages, tiamulin was evaluated for treatment of experimentally induced mycoplasmal pneumonia. Pneumonia was induced in respiratory tract disease-free swine by intratracheal inoculation of a lung homogenate containing Mycoplasma hyopneumoniae. Eleven days after inoculation, when more than 20% of pigs were coughing, pigs were allotted to 3 or 4 groups (n = 8 pigs each) and were given regimens of no medication or 60 mg, 120 mg, or 180 mg of tiamulin/L of drinking water for 10 days. Twenty-one days after cessation of medication, pigs were euthanatized and then were necropsied. Results obtained from the 3 trials did not indicate significant difference among treatment groups in severity of macroscopic or microscopic lesions induced by M hyopneumoniae or in detection of M hyopneumoniae by use of immunofluorescent technique. Clinical evaluations, daily gain, and feed efficiency did not differ significantly among treatment groups. In this study, tiamulin administration did not have beneficial effects in swine with mycoplasmal pneumonia.
authors.affiliation: Veterinary Medical Research Institute, Iowa State University, Ames 50011.
authors.forename: R F
authors.initials: RF
authors.lastname: Ross
authors.forename: D F
authors.initials: DF
authors.lastname: Cox
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004224:Diterpenes / Q000008:administration & dosage / Q000627:therapeutic use; D004341:Drug Evaluation / Q000662:veterinary; D005260:Female; D008297:Male; D045729:Pneumonia of Swine, Mycoplasmal / Q000188:drug therapy / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy*; D014881:Water Supply
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; C014224:tiamulin