title: Partial cross-reactivity by suppressor cells induced during different experimental autoimmune diseases.
abstract: Following injection of rat red cells, mice develop anti-red cell autoantibodies and subsequently suppressor T cells specific for these. Likewise, following recovery from non-lethal malaria, they develop suppressor T cells which suppress the anti-lymphocyte autoantibodies induced by lethal malaria parasites. Neither type of suppressor cell affected non-autoantibody components of the response, nor a response to sheep red cells. However, there was variable but significant cross-suppression of the respective autoantibody responses by both types of suppressor cell. Possible reasons for this unexpected cross-reaction are discussed.
authors.forename: J H
authors.initials: JH
authors.lastname: Playfair
authors.forename: J B
authors.initials: JB
authors.lastname: De Souza
authors.forename: P R
authors.initials: PR
authors.lastname: Hutchings
authors.forename: A
authors.initials: A
authors.lastname: Cooke
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D003429:Cross Reactions; D004912:Erythrocytes / Q000276:immunology; D008288:Malaria / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D010961:Plasmodium / Q000276:immunology; D010962:Plasmodium berghei / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D001323:Autoantibodies