Modulation of prostacyclin synthetase by cicletanine and drugs which affect ion transport.
Cicletanine, a drug which affects membrane ion transport, induces a marked increase of the liberation of PGI2 as demonstrated by the increase of the stable metabolites in the plasma following intravenous administration of arachidonic acid. Furthermore, the inhibiting effect of tranylcypromine on prostacyclin synthetase is completely removed by this pharmacon. These observations are suggestive that this drug presents a scope for treatment of thrombotic disorders as well as hypertension.
Deby
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Lab. of Applied Biochemistry U.E.L. Liege, Belgium.
Bourgain
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Andries
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Braquet
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D000818:Animals; D000959:Antihypertensive Agents; D001693:Biological Transport, Active / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors; D004232:Diuretics / Q000494:pharmacology*; D011464:Epoprostenol / Q000097:blood; D007477:Ions; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011725:Pyridines; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013927:Thrombosis / Q000188:drug therapy; D014191:Tranylcypromine / Q000037:antagonists & inhibitors / Q000494:pharmacology
D000959:Antihypertensive Agents; D016861:Cyclooxygenase Inhibitors; D004232:Diuretics; D007477:Ions; D011725:Pyridines; D014191:Tranylcypromine; C038068:cicletanine; D011464:Epoprostenol; D011451:Prostaglandin-Endoperoxide Synthases