Striatal topography of D-2 receptors correlates with indexes of cholinergic neuron localization.
The topography of dopamine D-2 receptor sites determined from autoradiographs of the rat striatum was compared with previously published values for choline acetyltransferase activity and high-affinity choline uptake within subregions of the striatum. The density of D-2 sites in the caudate-putamen correlates strikingly with these indexes of cholinergic neuron distribution.
Joyce
J N
JN
Marshall
J F
JF
D000818:Animals; D001345:Autoradiography; D002794:Choline / Q000378:metabolism; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002799:Cholinergic Fibers / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D009714:Nucleus Accumbens / Q000378:metabolism; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism*; D017448:Receptors, Dopamine D2; D013134:Spiperone / Q000378:metabolism
D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D013134:Spiperone; D002795:Choline O-Acetyltransferase; D002794:Choline; D004298:Dopamine