Decreased suppressor cell activity after surgery.
The effect of surgery on suppressor cell (SC) activity assessed in a ConA assay and concentration of OKT8+ cells in peripheral blood were studied in 16 patients with stage 0 cancer of uterus. An evident decrease in the number of freshly obtained OKT8+ and cultured for 20 hr with ConA OKT8+ cells and subsequently a drop in whole blood suppressor activity were found in the immediate postoperative period. The recovery of SC activity but not of OKT8+ cell level was observed on day 5. A nonsignificant decrease in E-RFC suppressor activity compared with that of whole blood SC suggests that function of T-suppressors has not been affected. The non-T cells did not produce any suppressive effect. These results indicate that the postoperative drop in the blood SC activity is due to the temporary depletion and not to the depressed function of SC.
Grzelak
I
I
Olszewski
W L
WL
Engeset
A
A
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D003208:Concanavalin A; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008875:Middle Aged; D013514:Surgical Procedures, Operative; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014594:Uterine Neoplasms / Q000601:surgery
D000911:Antibodies, Monoclonal; D003208:Concanavalin A