[Epidemiologic characteristics of 21 peranesthetic anaphylactoid accidents observed in a population of 12,855 surgically treated patients].
A study of anaphylactoid reactions (AR) observed between September 1982 and September 1983 was carried out in the surgical departments of a French regional hospital. The patients who had presented clinical symptoms suggesting an AR (bronchospasm, collapse, tachycardia, with or without skin rash) during a general anaesthesia were included in this study. A precise history of previous anaesthesias and allergy was taken; allergological testing was carried out six to eight weeks after the AR. It included intradermal skin tests (ST) and a human basophil degranulation test (HBDT) with the suspected drugs. Out of 12,855 patients operated on under general anaesthesia in the hospital, 21 AR were seen during the year under study, in 18 women and 3 men, of median age 27 years (extreme values: 11 and 62). The median number of previous anaesthesias was 2 (extreme values: 0--in 4 cases- and 22). Cardiocirculatory abnormalities were the most frequent clinical symptoms of the AR: they consisted of decreased arterial pressure in 13 cases, with 8 cases of vascular collapse. Respiratory symptoms were less frequent but severe bronchospasm was observed in 5 cases. Skin rashes were seen simultaneously in 13 out of the 21 observations. A history of allergy was found in 11 patients. Total IgE serum concentration averaged 134 kU X 1(-1) (extreme values: 32-378). Results of histamine-sensitivity skin tests were not significantly different from those observed in a control group. Calcemia and magnesemia were in the normal range. One to four drugs were tested in each patient: 41 tests combining ST and HBDT were carried out.(ABSTRACT TRUNCATED AT 250 WORDS)
Vuitton
D
D
Neidhardt-Audion
M
M
Girardin
P
P
Racadot
E
E
Geissmann
C
C
Laurent
R
R
Barale
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000530:Alfaxalone Alfadolone Mixture / Q000009:adverse effects; D000707:Anaphylaxis / Q000139:chemically induced / Q000453:epidemiology* / Q000276:immunology; D000758:Anesthesia / Q000009:adverse effects*; D001491:Basophils / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects; D012306:Risk; D012737:Sex Factors; D012882:Skin Tests; D013390:Succinylcholine / Q000009:adverse effects; D013874:Thiopental / Q000009:adverse effects
D003473:Neuromuscular Nondepolarizing Agents; D000530:Alfaxalone Alfadolone Mixture; D013390:Succinylcholine; D013874:Thiopental
Caractéristiques épidémiologiques de 21 accidents anaphylactoïdes peranesthésiques observés dans une population de 12 855 sujets opérés.