Decrease of bleeding time by a peptide fraction from bovine factor VIII in laboratory animals.
A peptide fraction of low molecular weight prepared from bovine Factor VIII by enzymatic hydrolysis (Vueffe) reduces bleeding time in laboratory animals. In this study the haemostatic action in mice, rats and rabbits was investigated using different experimental conditions. This action was observed in animals with either normal or experimentally prolonged bleeding time, thus suggesting better efficacy in pathological situations. The evidence obtained following different routes of administration confirmed the activity of the compound. The efficacy was present at very low doses in all animal species without interfering either with platelets or with blood coagulation.
Gervasi
G B
GB
Baldacci Research Laboratories, Pisa, Italy.
Bartoli
C
C
Carpita
G
G
Baldacci
M
M
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001760:Bleeding Time; D001777:Blood Coagulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005169:Factor VIII / Q000032:analysis*; D006493:Heparin / Q000494:pharmacology; D051379:Mice; D010446:Peptide Fragments / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats
D010446:Peptide Fragments; D005169:Factor VIII; D006493:Heparin; D001241:Aspirin