Effects of enfenamic acid and its zinc salt on wound-healing.
Dose-matched comparison between zinc-salt of enfenamic acid and the parent compound was carried out in experimentally wounded male albino rats bearing either sutured incision, dead-space or excision wounds. Result showed that enfenamic-acid significantly decreased breaking-strength of incision wounds and this effects was totally reversed by zinc present in enfenamic acid-zinc salt. Both the parent compound and the salt had significant granulation suppressant effect in dead-space wounds. In excision wounds epithelization was enhanced by enfenamic acid only. The wound contraction was not affected by either test compound.
Rao
C M
CM
Department of Pharmacology, Kasturba Medical College, Manipal.
Kumar
A
A
Kulkarni
D R
DR
D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*; D015032:Zinc; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D062367:ortho-Aminobenzoates; C019126:enfenamic acid; D015032:Zinc