Inhibition of human gingival carcinoma cell growth by prostaglandins.
The inhibitory effects of various prostaglandins (PGA2, PGD2 and PGE2) on the growth of human gingival carcinoma cell line Ca 9-22 and human cervical carcinoma cell line HeLa were studied in vitro. 1. PGA2 and PGD2 significantly depressed Ca 9-22 cell proliferation in dose and time related fashion. 2. The inhibitory rate by PGs for Ca 9-22 cells exceeded than HeLa-cells. 3. IC50 value of PGD2 on growth of Ca 9-22 was calculated to be 4 micrograms/ml.
Suzuki
K
K
Department of Head and Neck Surgery, Nihon University School of Dentistry, Chiba, Japan.
Kobayashi
N
N
Moriya
Y
Y
Abiko
Y
Y
Suzuki
H
H
D002455:Cell Division / Q000187:drug effects; D015232:Dinoprostone; D005887:Gingival Neoplasms / Q000473:pathology*; D006367:HeLa Cells; D006801:Humans; D015230:Prostaglandin D2; D011453:Prostaglandins / Q000494:pharmacology*; D011454:Prostaglandins A / Q000494:pharmacology; D011457:Prostaglandins D / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000473:pathology
D011453:Prostaglandins; D011454:Prostaglandins A; D011457:Prostaglandins D; D011458:Prostaglandins E; C100008:prostaglandin A2; D015232:Dinoprostone; D015230:Prostaglandin D2