Differential recognition of Leishmania aethiopica antigens by lymphocytes from patients with local and diffuse cutaneous leishmaniasis. Evidence for antigen-induced immune suppression.
Data are presented to suggest that differential Ag expression by parasites derived from diffuse (DCL) vs local (LCL) cutaneous leishmaniasis patients may be responsible for the Ag-specific anergy seen in DCL patients. The evidence suggests that promastigotes derived from DCL patients express epitopes which preferentially stimulate suppressor activities in DCL patients. These determinants appear to be expressed less, if at all by promastigotes derived from LCL patients. The Ag-specific suppression or nonresponsiveness which dominates the immune response in DCL patients during an active infection can be abrogated by drug treatment or removal of live DCL parasites, which suggests that Ag-induced regulatory cells, probably of T cell lineage, are most likely responsible for the nonresponsiveness seen in untreated DCL patients. Thus the mechanisms of immune regulation operating in this disease differ from that of lepromatous leprosy where the specific unresponsiveness (anergy) is irreversible even after successful treatment.
Akuffo
H O
HO
Armauer Hansen Research Institute, Addis Ababa, Ethiopia.
Fehniger
T E
TE
Britton
S
S
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007891:Leishmania / Q000254:growth & development / Q000276:immunology*; D007896:Leishmaniasis / Q000276:immunology* / Q000469:parasitology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D013997:Time Factors
D000953:Antigens, Protozoan