Aluminium accumulation and immunosuppressive effect in recipients of kidney transplants.
Aluminium that has accumulated in the body is thought to have a generalised cytotoxic effect. A prospective study of aluminium accumulation in bone-that is, subclinical aluminium toxicity--was carried out in 94 recipients of kidney allografts, who were followed up for three years. Subclinical aluminium toxicity was found in 66 patients. A significantly smaller proportion of patients with aluminium accumulation experienced a rejection episode: 30 (58%) nu 12 (86%) who received grafts from cadavers and 4 (29%) nu 10 (71%) who received grafts from living donors. On multivariate analysis only the source of the kidney and aluminium accumulation were found to influence the rejection rate. These findings suggest that aluminium accumulation has an immunosuppressive effect.
Nordal
K P
KP
Department of Medicine, Rikshospitalet, Oslo, Norway.
Dahl
E
E
Albrechtsen
D
D
Halse
J
J
Leivestad
T
T
Tretli
S
S
Flatmark
A
A
D000328:Adult; D000535:Aluminum / Q000378:metabolism* / Q000506:poisoning; D001842:Bone and Bones / Q000378:metabolism*; D002102:Cadaver; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D011446:Prospective Studies; D014019:Tissue Donors
D000535:Aluminum