title: Tumour necrosis factor.
abstract: Tumour necrosis factor was originally thought to kill tumour cells but not normal cells and to be a principal mediator in macrophage-mediated killing of tumour cells. It is now known to have a broad spectrum of additional activity ranging from regulatory effects on normal cells to inhibitory effects on viruses and parasites.
authors.affiliation: Department of Immunology and Medical Microbiology, University of Florida College of Medicine, Gainesville 32610.
authors.forename: G E
authors.initials: GE
authors.lastname: Gifford
authors.forename: D A
authors.initials: DA
authors.lastname: Flick
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D051379:Mice; D009369:Neoplasms / Q000097:blood; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010272:Parasitic Diseases / Q000097:blood; D011817:Rabbits; D011994:Recombinant Proteins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma