title: Cardiovascular risk factors and age of onset of obesity in severely obese patients.
abstract: Aim of this study was to evaluate whether the age of onset of obesity might affect the prevalence of CV risk factors in severely obese patients. Five hundred forty-five (385 F aged 42.3 +/- 7.1 yrs, BMI 47.3 +/- 5.1 w/h2 and 160 M of 39.0 +/- 1.1 yrs and BMI of 41.8 +/- 5.3 w/h2) severely obese patients hospitalized in the Metabolic Unit between 1972 and 1985 were subdivided in four classes according to the age of onset of obesity. Severely obese women with maturity onset obesity (i.e. onset greater than or equal to 20 yrs) (MOO) had higher (p less than or equal to .01) serum glucose (118 vs 103 mg/dl) and triglyceride (167 vs 126 mg/dl) than those with early onset obesity (EOO) (i.e. onset less than or equal to 3 yrs) with the same age, BMI and smoking habits. Similar trend was also found in men. In males arterial blood pressure was found to be higher (p less than or equal to .01) in EOO than in MOO (SBP = 152 vs 133 mmHg and DBP = 92 vs 83 mmHg). Similar trend was found in females. In conclusion age of onset of obesity may, at least in part, affect the prevalence of cardiovascular risk factors in severe obesity.
authors.affiliation: Istituto di Medicina Interna e Malattie Dismetaboliche, Università degli Studi di Napoli, Italia.
authors.forename: R
authors.initials: R
authors.lastname: Borrelli
authors.forename: F
authors.initials: F
authors.lastname: Contaldo
authors.forename: L A
authors.initials: LA
authors.lastname: Reed
authors.forename: C
authors.initials: C
authors.lastname: Isernia
authors.forename: G
authors.initials: G
authors.lastname: Di Biase
authors.forename: M
authors.initials: M
authors.lastname: Mancini
mesh_terms: D000328:Adult; D000367:Age Factors; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology*; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology; D006953:Hyperlipoproteinemia Type IV / Q000209:etiology; D006973:Hypertension / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D012307:Risk Factors