Induction of experimental allergic sialadenitis in mice.
This article reports that sialadenitis developed in female CRJ:CD-1 mice thymectomized 3 days after birth and later immunized with a homogenate of the submandibular salivary gland emulsified with complete Freund's adjuvant. Significant inflammatory changes did not develop in various control groups, including animals thymectomized at Day 3 but not immunized and animals not thymectomized on the day of birth but immunized. Because a more marked decrease of Lyt 2+ cells was found in mice thymectomized on Day 3 after birth than in neonatally thymectomized mice, thymectomy at 3 days of age is more effective for the induction of sialadenitis, presumably by markedly decreasing a population of suppressor T cells. The lesions observed in mice with sialadenitis were mostly composed of small and medium-sized lymphocytes stained by anti-Thy 1.2 and Lyt 2 antibodies and in later stages by immunoglobulin-containing cells in the periphery of inflammatory lesions.
Hayashi
Y
Y
Sato
M
M
Hirokawa
K
K
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000032:analysis; D000950:Antigens, Ly / Q000032:analysis; D004195:Disease Models, Animal; D005260:Female; D005455:Fluorescent Antibody Technique; D005620:Freund's Adjuvant; D008213:Lymphocyte Activation; D051379:Mice; D012466:Salivary Gland Diseases / Q000209:etiology*; D012793:Sialadenitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D013154:Spleen / Q000166:cytology; D013363:Submandibular Gland / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000473:pathology; D013934:Thymectomy
D000906:Antibodies; D000950:Antigens, Ly; D005620:Freund's Adjuvant