title: Treatment of gram-negative folliculitis with isotretinoin: positive clinical and microbiologic response.
abstract: Thirty-two patients with gram-negative folliculitis were treated with 0.47 to 1.0 mg/kg/day of isotretinoin. Serial microbiologic evaluations demonstrated rapid clearing of the face and nasal mucosa of gram-negative rods. The clinical response was rapid, complete, and induced prolonged remissions. Twenty-six of thirty-two patients developed Staphylococcus aureus nasal carriage by the end of the 20-week treatment course. Isotretinoin has decided advantages over previously reported therapies for gram-negative folliculitis.
authors.forename: W D
authors.initials: WD
authors.lastname: James
authors.forename: J J
authors.initials: JJ
authors.lastname: Leyden
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D001424:Bacterial Infections / Q000188:drug therapy*; D005499:Folliculitis / Q000188:drug therapy* / Q000209:etiology; D006090:Gram-Negative Bacteria; D006801:Humans; D007536:Isomerism; D015474:Isotretinoin; D014212:Tretinoin / Q000627:therapeutic use*
chemical_list: D014212:Tretinoin; D015474:Isotretinoin