title: Nontoxic concentration of amphotericin B for intravitreal use--evaluated by in vitro ERG.
abstract: Amphotericin B (AMPH)-induced changes of the electroretinogram (ERG) were studied in the in vitro eye-cup of the albino rabbit. The a-wave, b-wave, oscillatory potentials and c-wave were not changed by 1 microM AMPH, and these all were slightly suppressed by 5 microM AMPH. These changes were mostly reversible. The b-wave and oscillatory potentials were greatly suppressed by 50 microM AMPH. These changes were only partially reversible 75 minutes after re-perfusion without AMPH.
authors.affiliation: Department of Ophthalmology Kanazawa University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kawasaki
authors.forename: J
authors.initials: J
authors.lastname: Ohnogi
authors.forename: Y
authors.initials: Y
authors.lastname: Okayama
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D004596:Electroretinography; D066298:In Vitro Techniques; D007267:Injections; D009994:Osmolar Concentration; D010477:Perfusion; D011817:Rabbits; D012160:Retina / Q000187:drug effects*; D014822:Vitreous Body
chemical_list: D000666:Amphotericin B