Involvement of arachidonate-dependent lipid mediators and platelet-activating factor in experimental murine contact dermatitis.
A 5-lipoxygenase inhibitor (5-LPI) and a platelet-activating factor antagonist (PAF-A) were studied in dinitrofluorobenzene (DNFB)-induced allergic and croton-oil-induced irritant murine contact dermatitis. Both inhibitors, at 1 and 5% concentrations, significantly reduced the ear swelling in allergic dermatitis while irritant dermatitis was far less affected. This suggests that 5-lipoxygenase-dependent mediators and PAF are involved in allergic contact dermatitis and that these mediators play only a minor role in irritant dermatitis.
Csatò
M
M
Department of Dermatology, University of Münster, FRG.
Rosenbach
T
T
Czarnetzki
B M
BM
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000502:physiology*; D002199:Capillary Permeability / Q000187:drug effects; D003436:Croton Oil; D003877:Dermatitis, Contact / Q000473:pathology / Q000503:physiopathology*; D004139:Dinitrofluorobenzene; D004431:Ear, External / Q000473:pathology; D005260:Female; D008055:Lipids / Q000502:physiology*; D016859:Lipoxygenase Inhibitors; D051379:Mice; D008807:Mice, Inbred BALB C; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*
D001095:Arachidonic Acids; D008055:Lipids; D016859:Lipoxygenase Inhibitors; D010972:Platelet Activating Factor; D016718:Arachidonic Acid; D003436:Croton Oil; D004139:Dinitrofluorobenzene