Transforming growth factor-beta-like activity in tumors of the central nervous system.
Transforming growth factor type beta (TGF-beta) is a ubiquitous peptide with wide-ranging regulatory functions. This paper reports the initial isolation of TGF-beta activity from human glial and mesenchymally derived tumors and a human glial tumor cell line. While its physiological function at the molecular level is not yet defined, it is believed that this peptide plays a central role in the control of growth and transformation, with the exact role it plays being a function of the entire set of growth factors present in a given cell.
Clark
W C
WC
Department of Neurosurgery, University of Tennessee, Memphis.
Bressler
J
J
D000818:Animals; D001254:Astrocytoma / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D005910:Glioma / Q000378:metabolism; D006801:Humans; D008577:Meningeal Neoplasms / Q000378:metabolism*; D008579:Meningioma / Q000378:metabolism; D008970:Molecular Weight; D010455:Peptides / Q000378:metabolism*; D015291:Transforming Growth Factors; D014407:Tumor Cells, Cultured
D010455:Peptides; D015291:Transforming Growth Factors