Follow-up of the antibody response to measles vaccine in a rural area of Guinea-Bissau.
One hundred and fourty-four children who either were already immune or had been successfully immunized against measles were reexamined after 16 months. All still had circulating Elisa antibodies at a clearly detectable level. Titres were higher in the group of children stated to have had measles prior to the immunization. None of the children had measles after immunization. Boostering by the wild virus may have occurred, whereas no evidence of a booster effect from the vaccine was found. About one third of the children were underweight. Plasmodium falciparum parasitaemia rate, and also its seasonality, varied with the location of the child's homestead. Even children exposed to mesoendemic P. falciparum malaria and moderate malnutrition can be successfully immunized with a conventional live attenuated measles vaccine from 8 months of age, which probably results in a lasting protection.
Smedman
L
L
Department of Paediatrics, Karolinska Institute, Stockholm, Sweden.
Gunnlaugsson
G
G
Norrby
E
E
Silva
M C
MC
Zetterström
R
R
D000914:Antibodies, Viral / Q000096:biosynthesis*; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006169:Guinea-Bissau; D006801:Humans; D007223:Infant; D008288:Malaria / Q000635:transmission; D008297:Male; D008458:Measles Vaccine / Q000276:immunology*; D011502:Protein-Energy Malnutrition / Q000150:complications / Q000453:epidemiology; D012424:Rural Population; D012621:Seasons
D000914:Antibodies, Viral; D008458:Measles Vaccine