Blood pressure response to tyramine-enriched meal before and during MAO-inhibition in man: influence of dosage regimen.
In an open study oral tyramine in variable doses was administered to six healthy volunteers under three different conditions: 1) without moclobemide, 2) under moclobemide steady-state conditions (3 X 200 mg moclobemide daily) one hour after moclobemide intake and 3) under moclobemide steady-state conditions simultaneously with moclobemide. It was shown that the amount of tyramine effecting 30-50 mmHg systolic blood pressure increase was roughly doubled when moclobemide was administered together with tyramine instead of one hour before tyramine intake. The time interval between tyramine ingestion and maximal blood pressure increase did not differ significantly between conditions 2) and 3). The conclusion of this study is that moclobemide should always be taken at the end of a meal, which is anyway the usual time for drug intake.
Müller
T
T
Department of Medicine, University Hospital, Zurich, Switzerland.
Gieschke
R
R
Ziegler
W H
WH
D000284:Administration, Oral; D000328:Adult; D001549:Benzamides / Q000008:administration & dosage / Q000009:adverse effects*; D004334:Drug Administration Schedule; D004357:Drug Synergism; D004361:Drug Tolerance; D005502:Food / Q000009:adverse effects; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D014439:Tyramine / Q000008:administration & dosage / Q000009:adverse effects*
D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D020912:Moclobemide; D014439:Tyramine