Bile acid binding and hypocholesterolemic activity of a new anion exchange resin from 2-methylimidazol and epichlorohydrin.
A new anion exchange resin with an imidazolium salt on a epoxide polymer skeleton was synthesized. This white powder material was odorless and tasteless. The in vitro sodium cholate binding of this resin was much more potent than that of cholestyramine. The hypocholesterolemic activity of this resin in cholesterol-fed rabbits proved to be 4.3 times more potent than that of cholestyramine. These results suggest that effective reduction of plasma cholesterol may be achieved with lower doses of this resin.
Toda
H
H
Central Research Laboratory, Mitsubishi Yuka Company, Ltd., Ibaraki, Japan.
Kihara
K
K
Hashimoto
M
M
Mizogami
S
S
D000818:Animals; D000924:Anticholesteremic Agents; D001647:Bile Acids and Salts / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002728:Chlorohydrins / Q000032:analysis*; D004811:Epichlorohydrin / Q000032:analysis* / Q000494:pharmacology; D007093:Imidazoles / Q000032:analysis* / Q000494:pharmacology; D007474:Ion Exchange; D007475:Ion Exchange Resins / Q000032:analysis / Q000494:pharmacology*; D008297:Male; D011817:Rabbits
D000924:Anticholesteremic Agents; D001647:Bile Acids and Salts; D002728:Chlorohydrins; D007093:Imidazoles; D007475:Ion Exchange Resins; D004811:Epichlorohydrin; C032655:2-methylimidazole