Prevention of endotoxaemia in obstructive jaundice--a comparative study of bile salts.
Systemic endotoxaemia is associated with postoperative renal dysfunction in obstructive jaundice, and can be prevented by the pre-operative administration of certain bile salts. In order to find the most effective bile salt for use in this condition, a comparison of the anti-endotoxic activities of different bile salts was performed. Bile salts were incubated in vitro with endotoxin and the resultant endotoxin level was measured with a quantitative limulus assay. The in vivo effects of different oral bile salts on the intestinal absorption of radiolabelled endotoxin from rats with obstructive jaundice were compared. The in vitro and in vivo anti-endotoxic activities of bile salts related to their known detergent activities. Deoxycholic acid and its conjugates were the most effective and should be the bile salts of choice for further clinical evaluation in obstructive jaundice in man.
Pain
J A
JA
Department of Surgery, Royal Surrey County Hospital, Guildford, UK.
Bailey
M E
ME
D000818:Animals; D001647:Bile Acids and Salts / Q000627:therapeutic use*; D002635:Chenodeoxycholic Acid / Q000627:therapeutic use; D002779:Cholestasis / Q000150:complications*; D019826:Cholic Acid; D002793:Cholic Acids / Q000627:therapeutic use; D003840:Deoxycholic Acid / Q000627:therapeutic use; D004731:Endotoxins / Q000037:antagonists & inhibitors / Q000097:blood* / Q000378:metabolism; D004926:Escherichia coli; D006002:Glycodeoxycholic Acid / Q000627:therapeutic use; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013656:Taurocholic Acid / Q000627:therapeutic use; D013657:Taurodeoxycholic Acid / Q000627:therapeutic use; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
D001647:Bile Acids and Salts; D002793:Cholic Acids; D004731:Endotoxins; D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid; D006002:Glycodeoxycholic Acid; D013657:Taurodeoxycholic Acid; D013656:Taurocholic Acid; D014580:Ursodeoxycholic Acid; D019826:Cholic Acid