Secondary structure of human plasma fibronectin: conformational change induced by calf alveolar heparan sulfates.
The quantitative analysis of circular dichroic spectra of native human plasma fibronectin according to the method of Provencher and Glöckner [Provencher, S. W., & Glöckner, J. (1981) Biochemistry 20, 33-37] indicated the presence of beta-sheet (79%), beta-turn (21%), but no alpha-helix or random coil in the secondary structure. The calf alveolar heparan sulfates induced a change in the conformation of fibronectin: the magnitude of the change depended on the molecular properties of the particular heparan sulfate preparations.
Osterlund
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E
Eronen
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Osterlund
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K
Vuento
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M
D000818:Animals; D002417:Cattle; D002846:Chromatography, Affinity; D002942:Circular Dichroism; D005353:Fibronectins / Q000097:blood*; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006497:Heparan Sulfate / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D011487:Protein Conformation; D011650:Pulmonary Alveoli; D013056:Spectrophotometry, Ultraviolet
D005353:Fibronectins; D006025:Glycosaminoglycans; D006497:Heparan Sulfate