Fluorodeoxyuridine-induced sex differences in baseline sister-chromatid exchanges in C57BL/6 mice and Chinese hamsters.
The baseline sister-chromatid exchanges (SCEs) and the percentage of first (M1), second (M2) and third or higher metaphase (M3+) chromosomes were analysed in bone-marrow cells of male and female C57BL/6 mice and Chinese hamsters following serial intraperitoneal injections of 40 micrograms/g body weight (b.w.) of 5-bromo-2'-deoxyuridine (BrdUrd) and 2 micrograms/g b.w. of 5-fluorodeoxyuridine (FdUrd) or 40 micrograms/g b.w. of BrdUrd and 10 micrograms/g b.w. of deoxycytidine (dC). Female animals receiving BrdUrd/FdUrd showed significantly higher (P less than 0.01) baseline SCEs compared to the other groups. No sex difference in the baseline SCEs was found in animals treated with BrdUrd/dC. The distribution patterns of M1, M2 and M3+ metaphases in BrdUrd/FdUrd-treated animals differ significantly from those in BrdUrd/dC-treated animals.
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D000818:Animals; D001973:Bromodeoxyuridine; D006224:Cricetinae; D003412:Cricetulus / Q000235:genetics; D003841:Deoxycytidine / Q000494:pharmacology; D005260:Female; D005467:Floxuridine / Q000494:pharmacology*; D008297:Male; D008677:Metaphase; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics; D012737:Sex Factors; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D005467:Floxuridine; D003841:Deoxycytidine; D001973:Bromodeoxyuridine