title: Phase II trial of 4'-epi-doxorubicin in locally advanced or metastatic gastric cancer.
abstract: Patients with locally advanced or metastatic gastric adenocarcinoma received an i.v. bolus of 4'-epi-doxorubicin, 75/mg/m2/cycle, every 21 days. Partial responses were observed in 5 of 23 evaluable patients (21.7%). Treatment was generally well tolerated and toxicity was mild. The response rate to epirubicin appears to be very similar to that reported for doxorubicin. Larger doses of epirubicin could be safely used in future studies, and further evaluation of epirubicin in phase III trials is indicated.
authors.affiliation: Grupo Argentino de Tratamiento de los Tumores Sólidos (GATTS), Buenos Aires, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Cazap
authors.forename: R
authors.initials: R
authors.lastname: Estevez
authors.forename: M
authors.initials: M
authors.lastname: Bruno
authors.forename: D
authors.initials: D
authors.lastname: Levy
authors.forename: C
authors.initials: C
authors.lastname: Algamiz
authors.forename: R
authors.initials: R
authors.lastname: Chacon
authors.forename: C
authors.initials: C
authors.lastname: Badano
authors.forename: A
authors.initials: A
authors.lastname: Romero
authors.forename: G
authors.initials: G
authors.lastname: Desimone
authors.forename: E
authors.initials: E
authors.lastname: Roca
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D015251:Epirubicin; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013237:Stereoisomerism; D013274:Stomach Neoplasms / Q000188:drug therapy*
chemical_list: D015251:Epirubicin; D004317:Doxorubicin