Intravenous cyclophosphamide and methylprednisolone for the treatment of bronchiolitis obliterans and interstitial fibrosis associated with crysotherapy.
A patient with rheumatoid arthritis receiving intramuscular gold developed severe pulmonary insufficiency. Histopathology revealed both bronchiolitis obliterans and interstitial fibrosis possibly related to gold therapy. The patient was successfully treated with IV cyclophosphamide and prednisone. During the course of therapy, hypogammaglobulinemia without detectable IgM developed.
Fort
J G
JG
Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107.
Scovern
H
H
Abruzzo
J L
JL
D000361:Agammaglobulinemia / Q000139:chemically induced; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001989:Bronchiolitis Obliterans / Q000139:chemically induced / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006046:Gold / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007275:Injections, Intravenous; D008168:Lung / Q000473:pathology; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D013902:Radiography, Thoracic
D007075:Immunoglobulin M; D006046:Gold; D003520:Cyclophosphamide; D008775:Methylprednisolone