T-lymphocyte subset changes in recurrent aphthous stomatitis.
Immunocytochemical techniques using monoclonal antibodies directed against T-lymphocyte surface antigens (OKT3, OKT4, and OKT8) were used to investigate changes in the T-cell subpopulations throughout the natural time course of recurrent aphthous stomatitis (RAS). All lesions contained large numbers of OKT3-positive T cells. Preulcerative lesions were characterized by many OKT4-positive inducer/helper cells and few OKT8-positive suppressor/cytotoxic cells (T4:T8 approximately equal to 2:1). The ulcerative lesion contained large numbers of OKT8-positive suppressor/cytotoxic cells and only a very small number of OKT4-positive cells (T4:T8 approximately equal to 1:10). The healing lesion once again became dominated by OKT4-positive cells, with only a small number of OKT8 positive cells present (T4:T8 approximately equal to 10:1). The results support the role of lymphocytotoxicity in the establishment of the RAS lesion and may suggest a local immunoregulatory imbalance. NK cells, Leu-7 positive, were also identified in the preulcerative lesions and very early ulcerative lesions.
Savage
N W
NW
Seymour
G J
GJ
Kruger
B J
BJ
D000911:Antibodies, Monoclonal / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D007958:Leukocyte Count; D010641:Phenotype; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000145:classification* / Q000166:cytology / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal