title: Chronic pancreatitis, HLA and autoimmunity.
abstract: HLA-A and B antigens were studied in 88 Caucasoids with chronic pancreatitis resident in the Manchester area. In the subgroup of 52 patients with alcohol-related chronic pancreatitis HLA-B21 was significantly increased in frequency compared with 344 local controls (Pc = 0.0128). In the non-alcoholic sub-group of 36 patients, the incidence of HLA-A1 was significantly higher than in controls (Pc = 0.0021); whilst HLA-B8 was present in 38.8% of patients and 27.9% of controls. When these data are amalgamated with data from Lyon (France), the antigen HLA-A1 is significantly associated with non-alcoholic chronic pancreatitis.
authors.affiliation: University Department of Gastroenterology, Manchester Royal Infirmary, U.K.
authors.forename: R J
authors.initials: RJ
authors.lastname: Anderson
authors.forename: P A
authors.initials: PA
authors.lastname: Dyer
authors.forename: D
authors.initials: D
authors.lastname: Donnai
authors.forename: P T
authors.initials: PT
authors.lastname: Klouda
authors.forename: R
authors.initials: R
authors.lastname: Jennison
authors.forename: J M
authors.initials: JM
authors.lastname: Braganza
mesh_terms: D000437:Alcoholism / Q000150:complications; D001327:Autoimmune Diseases / Q000150:complications*; D002137:Calculi / Q000150:complications; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000150:complications / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens