title: Effects of experimental defects of the articular disc of the temporomandibular joint in rats.
abstract: Triangular defects were made in different locations of the disc in rat temporomandibular joints. After 3 months the following effects were observed. Central defects had become rounded without gross changes in the mandibular head. Peripheral defects were enlarged towards the centre, occasionally accompanied by condylar hyperplasia. Microscopically the cartilagenous covering of the mandibular head in all operated cases was characterized by thickening, dispersion of cells normally closely packed in the intermediate zone, and the constant appearance of a tear parallel to the surface.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Leiden, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Lekkas
authors.forename: G L
authors.initials: GL
authors.lastname: Honee
authors.forename: A
authors.initials: A
authors.lastname: van den Hooff
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000293:injuries* / Q000473:pathology; D005260:Female; D006965:Hyperplasia; D008297:Male; D008335:Mandibular Condyle / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013704:Temporomandibular Joint / Q000293:injuries* / Q000473:pathology