Abnormalities in the expression of the leucocyte-common antigen in chronic lymphocytic leukaemia.
The surface glycoproteins of lymphocytes isolated from patients suffering from B cell chronic lymphocytic leukaemia (B-CLL) have been studied by radioactive labelling with impermeable probes and with MoAb. Several features not found in normal B cells have been observed. The abnormalities found in the expression of polypeptides of the leucocyte common (L-C) antigen, identified by appropriate MoAb, have been examined in detail. It has been shown by both biochemical analysis and MoAb binding that this group of polypeptides can, within a panel of B-CLL patients, range from a typical B cell pattern to the pattern resembling that normally found in T cells. The T lymphocyte profile is correlated with a poor prognosis (MVA C rating) and in the one patient where a change in the glycoprotein profile towards that of the T cell was observed, the change coincided with a clinical deterioration. The biological significance of the molecular diversity is discussed.
Smith
S K
SK
Brown
V A
VA
Dewar
A E
AE
Stockdill
G
G
Cohen
B
B
Maddy
A H
AH
D000937:Antigen-Antibody Reactions; D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology*; D004586:Electrophoresis; D006023:Glycoproteins / Q000032:analysis; D006649:Histocompatibility Antigens / Q000276:immunology*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology*; D017493:Leukocyte Common Antigens; D008285:Major Histocompatibility Complex; D008970:Molecular Weight; D011379:Prognosis; D013601:T-Lymphocytes / Q000276:immunology
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D006023:Glycoproteins; D006649:Histocompatibility Antigens; D017493:Leukocyte Common Antigens