Effect of lipid peroxidation on heart mitochondria oxygen consuming and calcium transporting capacities.
The incubation of rabbit heart mitochondria in the presence of ferrous ions induced lipid peroxidation which was accompanied by a reduction of mitochondrial respiratory capacity and Ca++ transport. The effects were more evident, when pyruvate was employed as respiratory substrate, and were partially prevented by catalase, while superoxide dismutase was ineffective.
Ceconi
C
C
Universitá degli Studi di Brescia, Cattedra di Cardiologia e di Chimica, Brescia, Italy.
Curello
S
S
Albertini
A
A
Ferrari
R
R
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002374:Catalase / Q000494:pharmacology; D005296:Ferrous Compounds / Q000494:pharmacology; D005609:Free Radicals; D015227:Lipid Peroxidation; D008929:Mitochondria, Heart / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D011773:Pyruvates / Q000494:pharmacology; D011817:Rabbits; D013482:Superoxide Dismutase / Q000494:pharmacology
D005296:Ferrous Compounds; D005609:Free Radicals; D011773:Pyruvates; D002374:Catalase; D013482:Superoxide Dismutase; D002118:Calcium