Absence of feedback inhibition of prolactin secretion by the prostate.
Previous observations in rodents and man have suggested the existence of feedback inhibition of pituitary prolactin secretion by the prostate. Thyrotrophin releasing hormone (TRH) tests performed in males before and after prostatectomy demonstrated no difference in prolactin or thyrotrophin (TSH) secretion. These data do not support the hypothesis of a prostate-pituitary feedback loop in the control of prolactin secretion. The results also imply that prostatic TRH acts in a paracrine manner.
Morrish
D W
DW
Department of Medicine, University of Alberta, Edmonton, Canada.
Crockford
P M
PM
D000368:Aged; D000369:Aged, 80 and over; D005246:Feedback; D006801:Humans; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*; D011467:Prostate / Q000502:physiology*; D011468:Prostatectomy; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000502:physiology
D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D013972:Thyrotropin