[Urinary excretion of 3-methylhistidine. Value and application to the study of protein catabolism].
The urinary excretion of 3-methylhistidine (3 MH) is considered an easy and reliable method to quantify muscle protein catabolism in man. The 3 MH/creatinine (Cr) ratio is thought to be a good index of fractional degradation of muscle fibre protein. In the present article, the stress is placed on the limitations of 3 MH assays an- on their clinical applications. In thyroid diseases and in malnutrition (anorexia nervosa), the 3 MH/Cr ratio differentiates clearly marasmic malnutrition without increase in protein catabolism from hypercatabolic states, such as hyperthyroidism, with excessive protein degradation. 3 MH measurements therefore appear to be useful to determine the contribution of protein catabolism to lean mass reduction.
Richard
J L
JL
Rodier
M
M
Bringer
J
J
Cavalie
G
G
Claustres
M
M
Bellet
H
H
Mirouze
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000856:Anorexia Nervosa / Q000652:urine*; D002648:Child; D003404:Creatinine / Q000652:urine; D003920:Diabetes Mellitus / Q000652:urine*; D005260:Female; D006639:Histidine / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008762:Methylhistidines / Q000652:urine*; D008875:Middle Aged; D009124:Muscle Proteins / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism; D051381:Rats; D013959:Thyroid Diseases / Q000652:urine*
D008762:Methylhistidines; D009124:Muscle Proteins; D006639:Histidine; D003404:Creatinine
L'excrétion urinaire de 3-méthylhistidine. Intérêt et application dans l'étude du catabolisme protidique.