title: [Clinical, electrophysiologic and endocrine effects of the perfusion of high doses of TRH in amyotrophic lateral sclerosis].
abstract: Eight patients with amyotrophic lateral sclerosis received 500 mg TRH by IV infusion, at a progressive rate during 3 hours. Only 3 patients noted subjective improvement of strength. Clinical muscular testing and H response study failed to show any change. Moreover modifications of the prolactin, growth hormone, TSH and T3 serum levels raise a question concerning the tolerance with long term utilization of TRH.
authors.affiliation: Service de Neurologie, Hôpital Sainte-Anne, Paris.
authors.forename: B
authors.initials: B
authors.lastname: Gueguen
authors.forename: J
authors.initials: J
authors.lastname: Puymirat
authors.forename: D
authors.initials: D
authors.lastname: Grouselle
authors.forename: M L
authors.initials: ML
authors.lastname: Piketty
authors.forename: J P
authors.initials: JP
authors.lastname: Bleton
authors.forename: M C
authors.initials: MC
authors.lastname: Bourdel
authors.forename: P
authors.initials: P
authors.lastname: Rondot
mesh_terms: D000110:Acetylcholinesterase / Q000134:cerebrospinal fluid; D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007262:Infusions, Intravenous; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D011388:Prolactin / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D000110:Acetylcholinesterase; D013974:Thyroxine
vernacular_title: Effets cliniques, électrophysiologiques et endocriniens de la TRH en perfusion à doses élevées dans la sclérose latérale amyotrophique.