Pharmacokinetics and tissue kinetics of 1 gm cefotetan prophylaxis in abdominal or vaginal hysterectomy.
Plasma and tissue levels of cefotetan after a single-gram intravenous preoperative dose were measured. Levels were high in some tissues (parametrium, fascia) but quite low in others (subcutaneous fat). The implications as to the prophylactic effectiveness of this drug are addressed.
Orr
J W
JW
Department of Gynecology and Obstetrics, Watson Clinic, Lakeland, FL.
Sisson
P F
PF
Barrett
J M
JM
Ellington
J R
JR
Jennings
R H
RH
Taylor
D L
DL
D000328:Adult; D015313:Cefotetan; D002513:Cephamycins / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D007044:Hysterectomy; D007045:Hysterectomy, Vaginal; D008875:Middle Aged
D002513:Cephamycins; D015313:Cefotetan