Identification of urinary 3-ethoxy-4-hydroxybenzoic and 3-ethoxy-4-hydroxymandelic acids after dietary intake of ethyl vanillin.
It has been discovered recently that several patients undergoing urinary organic acid profiling excrete high concentrations of 3-ethoxy-4-hydroxybenzoic acid and traces of 3-ethoxy-4-hydroxymandelic acid. These are believed to be the consequences of feeding the patients with synthetic diets flavoured with 3-ethoxy-4-hydroxybenzaldehyde, a vanilla-like artificial flavouring added to improve patient acceptance and taste. The syntheses, mass spectra and gas chromatographic behaviour of these and related compounds are presented.
Mamer
O A
OA
Montgomery
J A
JA
Deckelbaum
R J
RJ
Granot
E
E
D000328:Adult; D001547:Benzaldehydes / Q000378:metabolism*; D002648:Child; D005260:Female; D005421:Flavoring Agents / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates / Q000138:chemical synthesis / Q000652:urine*; D008297:Male; D008333:Mandelic Acids / Q000138:chemical synthesis / Q000652:urine*
D001547:Benzaldehydes; D005421:Flavoring Agents; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates; D008333:Mandelic Acids; C045943:3-ethoxy-4-hydroxymandelic acid; C045942:3-ethoxy-4-hydroxybenzoic acid; C045941:ethyl vanillin