Effect of isotretinoin on eccrine gland function.
Sweat secretion rate, stimulated by iontophoresis of pilocarpine, was measured before and during treatment with isotretinoin in 20 patients. Sweat secretion was increased during treatment in 15 patients (75%), but the mean increase of 15% was not statistically significant (P = 0.085, paired t-test; 95% confidence limits-0.2% to +30%) and no patients had a clinically apparent alteration of sweating. We conclude that there is no important change in stimulated sweating associated with isotretinoin therapy.
Rees
J L
JL
Department of Dermatology, Royal Victoria Infirmary, Newcastle-upon-Tyne, U.K.
Cox
N H
NH
D000293:Adolescent; D000328:Adult; D004439:Eccrine Glands / Q000187:drug effects*; D005260:Female; D006801:Humans; D015474:Isotretinoin; D008297:Male; D013545:Sweat Glands / Q000187:drug effects*; D013546:Sweating / Q000187:drug effects; D014212:Tretinoin / Q000494:pharmacology* / Q000627:therapeutic use
D014212:Tretinoin; D015474:Isotretinoin