Bio-electric conductivity potentials in experimental skin grafts.
Prior investigations have established that changes in bio-electric potentials accompany the processes of wound creation and healing. In order to investigate these changes in an experimental full-thickness skin graft model, grafts were harvested from the dorsa of eight albino rabbits. Changes in potential were recorded over a period of 32 days, using silver-silver chloride electrodes and a recording polygraph. The potential measured across the skin graft became increasingly more electropositive until, between days 1 and 2, the potential abruptly reversed polarity. This negative potential lasted until day 4, when the conductivity again became positive, with a slow return to baseline measurements by day 32. Although these observations may indicate a bio-electric counterpart to the cellular events of wound healing, more study is needed.
Angrist
R C
RC
Department of Ophthalmology, University of Wisconsin Medical School, Madison.
Gonnering
R S
RS
Dortzbach
R K
RK
Crawford
K
K
D000818:Animals; D003217:Conductometry; D004594:Electrophysiology; D008839:Microelectrodes; D011817:Rabbits; D016038:Skin Transplantation; D014945:Wound Healing / Q000502:physiology*