A biokinetic model for Rb in humans.
Although whole-body retention of Rb in humans has been characterized reasonably well, current biokinetic models for Rb do not provide detailed or accurate descriptions of the time-dependent distribution of this element within the body. In this paper we construct a physiologically descriptive biokinetic model that closely tracks the movement of Rb from the time of intake until virtually all of the ingested or injected quantity has been removed from the body. The selection process for model parameter values is described for a reference adult male, but we demonstrate how the model may be applied to non-reference humans, including young children. It is shown that the model accurately predicts long-term retention of Rb in both sexes and in different age groups and depicts changes with time in the internal distribution of Rb with sufficient accuracy to be suitable for dosimetric estimates even for the short-lived isotope 82Rb (T 1/2 = 75 s).
Leggett
R W
RW
Health and Safety Research Division, Oak Ridge National Laboratory, TN 37831.
Williams
L R
LR
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D012413:Rubidium / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D012413:Rubidium