[Acute promyelocytic leukemia with central nervous system leukemia--a report of two cases].
Two cases of promyelocytic leukemia (APL) with central nervous system leukemia (CNS-L) are reported. The first case displayed some symptoms similar to meningitis at onset, and the second case, during induction therapy suddenly developed left hemiplegia and was found to have CNS-L. There have been only a few case reports of APL associated with CNS-L and each has said that APL was rarely accompanied by CNS-L. Yet, of the reports registered with the Joint Committee for Hematologic neoplasm in Japan, the incidence of APL with CNS-L is not much lower than any of the other types of acute non-lymphocytic leukemia that can accompany a CNS-L. There fore, we feel that CNS-L should not be overlooked as an important prognostic consideration in APL cases.
Kobayashi
Y
Y
1st Dept. of Internal Medicine, Kyoto Prefectural Uni of Med.
Takahashi
S
S
Mizuno
T
T
Ozawa
M
M
Horiuchi
H
H
Maruo
M
M
Kondo
M
M
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002493:Central Nervous System Diseases / Q000473:pathology*; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000473:pathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness