Controlled release of diphosphonates from synthetic polymers to inhibit calcification.
Calcification is the most frequent cause of the failure of bioprosthetic heart valves fabricated from glutaraldehyde pretreated porcine aortic valves or bovine pericardium. Formulation and evaluation of controlled-release drug delivery system to inhibit bioprosthetic heart valve calcification is reviewed.
Golomb
G
G
Department of Pharmacy, School of Pharmacy, Hebrew University of Jerusalem, Israel.
D000818:Animals; D001705:Bioprosthesis; D002114:Calcinosis / Q000517:prevention & control*; D004164:Diphosphonates; D012968:Etidronic Acid; D006350:Heart Valve Prosthesis; D008297:Male; D008422:Materials Testing / Q000379:methods*; D011474:Prosthesis Design; D011475:Prosthesis Failure; D051381:Rats; D011919:Rats, Inbred Strains; D013499:Surface Properties
D004164:Diphosphonates; D012968:Etidronic Acid