Suppressor factor from a permanent T cell line inhibits allotransplantation reactions in vivo.
A permanent T cell line producing an antigen-non-specific suppressor factor was established. This factor inhibits the proliferation of lymphoid cells in vitro and, when injected in vivo, it suppresses the allotransplantation reaction. The line established may represent one of the cell populations playing an active role in the induction and maintenance of immunological tolerance.
Hasek
M
M
Holán
V
V
Vancatová
A
A
D000818:Animals; D002460:Cell Line; D007108:Immune Tolerance; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008810:Mice, Inbred C57BL / Q000276:immunology; D012513:Sarcoma, Experimental / Q000276:immunology; D016038:Skin Transplantation; D013491:Suppressor Factors, Immunologic; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism*; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D008222:Lymphokines; D013491:Suppressor Factors, Immunologic