N-(2-hydroxyethyl)phenazinium derivatives of oligonucleotides as effectors of the sequence-specific modification of nucleic acids with reactive oligonucleotide derivatives.
It has been found that mono- and especially diphenazinium derivatives of oligonucleotides complementary to the DNA sequence adjacent to the target sequence of the addressed alkylation of DNA, significantly enhance the extent and specificity of alkylation with p-(N-2-chloroethyl-N-methylamino)benzylamide derivatives of the addressing oligonucleotides, thus playing the role of effector of the sequence-specific (complementary addressed) modification.
Kutyavin
I V
IV
Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk.
Podyminogin
M A
MA
Bazhina YuN
Fedorova
O S
OS
Knorre
D G
DG
Levina
A S
AS
Mamayev
S V
SV
Zarytova
V F
VF
D000478:Alkylation; D001483:Base Sequence; D004277:DNA, Single-Stranded / Q000235:genetics*; D007202:Indicators and Reagents; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes / Q000138:chemical synthesis*; D010619:Phenazines; D013329:Structure-Activity Relationship
D004277:DNA, Single-Stranded; D007202:Indicators and Reagents; D015345:Oligonucleotide Probes; D010619:Phenazines