title: The influence of pharmacological manipulation of serotonin on serum growth hormone and luteinizing hormone levels in young turkeys (Meleagris gallopavo).
abstract: Serum growth hormone (GH) and luteinizing hormone (LH) levels were determined by homologous radioimmunoassay in 8 to 10-week-old domestic white turkeys treated by intraperitoneal injection of agents that alter serotonergic activity. The serotonin, 5-hydroxytryptamine (5-HT) precursor, 5-hydroxytryptophan (5-HTP), at doses of 80 and 150 mg/kg, produced a dose-related elevation in serum GH (P = .09) and no change in serum LH (P = .30). Administration of fluoxetine (10 mg/kg), a 5-HT reuptake blocker, produced no change in serum GH or LH. When fluoxetine injection preceded the administration of a nonstimulatory dose of 5-HTP, an elevation in GH was observed, but again no change in LH level was evident. Stimulation of postsynaptic 5-HT receptors with quipazine (.5 to 10.0 mg/kg) resulted in a similar elevation in GH; persistence of the effect was dose dependent. Quipazine administration had no influence on serum LH levels. Administration of methysergide (10 or 25 mg/kg), a 5-HT antagonist, induced no change in either serum GH or LH levels. Serotonergic input appears to stimulate GH release and has no apparent influence on LH release in young turkeys.
authors.forename: S C
authors.initials: SC
authors.lastname: Fehrer
authors.forename: J L
authors.initials: JL
authors.lastname: Silsby
authors.forename: W H
authors.initials: WH
authors.lastname: Burke
authors.forename: M E
authors.initials: ME
authors.lastname: el Halawani
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology; D013006:Growth Hormone / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D011814:Quipazine / Q000031:analogs & derivatives / Q000494:pharmacology; D011863:Radioimmunoassay / Q000662:veterinary; D012701:Serotonin / Q000502:physiology; D014422:Turkeys / Q000097:blood*
chemical_list: D005473:Fluoxetine; D012701:Serotonin; D011814:Quipazine; D007986:Luteinizing Hormone; D013006:Growth Hormone; D006916:5-Hydroxytryptophan; D008784:Methysergide