title: Role of eicosanoids in inflammatory reactions of rats.
abstract: Nonsteroidal antiinflammatory agents of several subgroups, regarding eicosanoid-producing enzyme inhibition, have been tested in vitro and in vivo. There was no overt correlation between cyclooxygenase and/or lipoxygenase inhibition in vitro and antiinflammatory effects. It is possible that eicosanoids do not play a key role as inflammatory mediators, i.e. that the course of the life-protecting inflammatory reaction is ensured by an ensemble of mediators, cellular events and further mechanisms of the whole living organism.
authors.affiliation: Wissenschaftsbereich Pharmakologie, Martin-Luther-Universität Halle-Wittenberg, DDR.
authors.forename: R
authors.initials: R
authors.lastname: Hirschelmann
authors.forename: S
authors.initials: S
authors.lastname: Zarnack
authors.forename: T
authors.initials: T
authors.lastname: Funke
authors.forename: K
authors.initials: K
authors.lastname: Schmidt
authors.forename: H
authors.initials: H
authors.lastname: Bekemeier
authors.forename: A J
authors.initials: AJ
authors.lastname: Giessler
authors.forename: H
authors.initials: H
authors.lastname: Ulbricht
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D016861:Cyclooxygenase Inhibitors; D004487:Edema / Q000188:drug therapy; D005260:Female; D007249:Inflammation / Q000188:drug therapy*; D016859:Lipoxygenase Inhibitors; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors