Historical communication: Philadelphia-positive chronic myelogenous leukemia followed for 27 years.
The patient we studied was diagnosed as having chronic myelogenous leukemia (CML), possibly radiation-induced, in 1960 at age 9, and a Philadelphia chromosome was first demonstrated in the neoplastic cells in 1961. Her subsequent clinical course has been cyclic, requiring periodic therapy, but there has been no karyotypic progression. A study in 1987 continued to show the typical t(9;22) translocation as the only cytogenetic alteration, and concurrent molecular investigation of the neoplastic cells revealed a breakpoint cluster region rearrangement, also typical of CML. The chromosomal and molecular data provide no obvious explanation for her remarkably prolonged survival.
Nowell
P C
PC
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6082.
Jackson
L
L
Weiss
A
A
Kurzrock
R
R
D001853:Bone Marrow / Q000473:pathology; D002648:Child; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D007953:Leukemia, Radiation-Induced / Q000235:genetics; D010677:Philadelphia Chromosome
D004273:DNA, Neoplasm