title: Fate of primary orbital dermis-fat grafts in guinea pigs.
abstract: A year-long study was undertaken to serially evaluate the tissue changes occurring in dermis-fat graft (DFG) after orbital implantation in nine guinea pigs. Methods used to evaluate the DFGs were histology, magnetic resonance imaging, morphometric analysis, and clinical observations. The histology of a 1-year-old failed human dermis-fat graft has been included for completeness. The study reveals that clinically successful DFGs have a fibrous capsule surrounding the DFG. Minimal revascularization was present. The grafts appear to undergo continual histological changes for approximately 9 months before a steady-state condition ensues. Of interest are changes in the deep-orbital fat posterior to the DFG.
authors.affiliation: Department of Opthalmology, Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston.
authors.forename: B R
authors.initials: BR
authors.lastname: Smith
authors.forename: C K
authors.initials: CK
authors.lastname: Beyer-Machule
authors.forename: H M
authors.initials: HM
authors.lastname: Cheng
authors.forename: W C
authors.initials: WC
authors.lastname: Pitts
mesh_terms: D000273:Adipose Tissue / Q000473:pathology / Q000637:transplantation*; D000818:Animals; D015353:Eye Enucleation; D006085:Graft Survival; D006168:Guinea Pigs; D008279:Magnetic Resonance Imaging; D009915:Orbit / Q000601:surgery*