The estimation of midazolam, a water-soluble benzodiazepine by gas liquid chromatography.
A simple, reliable and reproducible method for the estimation of midazolam in plasma samples is described. This involves extraction with benzene and estimation by gas-liquid chromatography using diazepam as the internal standard. Reproducibility was good and the extraction from plasma was 94% efficient.
Howard
P J
PJ
McClean
E
E
Dundee
J W
JW
D001569:Benzodiazepines / Q000097:blood*; D002138:Calibration; D002849:Chromatography, Gas; D003975:Diazepam / Q000097:blood; D004355:Drug Stability; D006801:Humans; D006993:Hypnotics and Sedatives / Q000097:blood*; D008874:Midazolam
D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; D003975:Diazepam; D008874:Midazolam