Periarthritis associated with basic calcium phosphate crystal deposition and low levels of serum alkaline phosphatase--report of three cases from one family.
Three siblings, 2 women and one man, from an Iranian-Jewish family with low serum levels of alkaline phosphatase (liver fraction) and symptomatic calcific periarthritis of multiple joints are described. Both parents and 2 additional siblings had normal serum alkaline phosphatase levels and no joint symptoms. The disease in the proposita, a 49-year-old woman, showed 3 unusual features: (1) no rise in acute phase serum proteins despite severe attacks of periarthritis; (2) refractoriness to treatment; (3) pure octacalcium phosphate found in a deposit obtained by biopsy.
Caspi
D
D
Department of Rheumatology, Tel Aviv Medical Center, Ichilov Hospital, Israel.
Rosenbach
T O
TO
Yaron
M
M
McCarty
D J
DJ
Graff
E
E
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood*; D001175:Arthrography; D002130:Calcium Phosphates / Q000378:metabolism*; D003460:Crystallization; D005260:Female; D006225:Hand / Q000000981:diagnostic imaging; D006801:Humans; D007492:Iran / Q000208:ethnology; D007557:Israel; D007585:Jews; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010489:Periarthritis / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*
D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; D000469:Alkaline Phosphatase; C485829:calcium phosphate, dibasic, anhydrous