title: [Clinical effectiveness and tolerance of auranofin in patients with chronic polyarthritis. Results of a multicenter long-term study].
abstract: In an open multicenter trial, 90 patients with rheumatoid arthritis were treated with a daily dose of 6 mg auranofin. The duration of the treatment was 12 months. A significant improvement in the following parameters was observed: grip strength, number of swollen and painful joints after the 4th month, blood erythrocyte sedimentation rate decreased significantly after the 2nd month. Of the 90 patients, 56 (62.3%) completed the therapy, in 14 (15.5%) it was discontinued because of side effects and in 8 (8.9%) because of inefficacy. 12 patients (13.3%) stated other reasons for discontinuing the therapy (non compliance). The reported side-effects were mostly gastrointestinal, especially diarrhoea and loose stools. The evaluation of results referring to the duration of the disease shows that patients with a duration of less than 2 years reacted better to the improvement with auranofin therapy than patients with a longer sickness history.
authors.affiliation: Rehabilitationszentrum für rheumatische Erkrankungen und Herz-Kreislaufkrankheiten der Pensionsversicherungsanstalt der Arbeiter, Saalfelden.
authors.forename: G
authors.initials: G
authors.lastname: Klein
authors.forename: H
authors.initials: H
authors.lastname: Schwann
authors.forename: B
authors.initials: B
authors.lastname: Mirtl
authors.forename: N
authors.initials: N
authors.lastname: Thumb
authors.forename: F
authors.initials: F
authors.lastname: Mayerhofer
authors.forename: F
authors.initials: F
authors.lastname: Singer
authors.forename: G
authors.initials: G
authors.lastname: Tausch
authors.forename: K
authors.initials: K
authors.lastname: Gaismayer
authors.forename: H
authors.initials: H
authors.lastname: Rieder
authors.forename: A
authors.initials: A
authors.lastname: Hartweger
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001310:Auranofin / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged
chemical_list: D001310:Auranofin
vernacular_title: Klinische Wirksamkeit und Verträglichkeit von Auranofin bei Patienten mit chronischer Polyarthritis. Ergebnisse einer multizentrischen Langzeitstudie.