title: Heterochromatic variants and their association with neoplasias: IV. Colon adenomas and carcinomas.
abstract: C-band polymorphisms in peripheral blood lymphocytes of 62 patients (33 with colon adenomas and 29 with colon carcinomas) were studied. A significant difference in the frequency of heterochromatic variants in chromosomes #1 in both colon adenoma (56%) and carcinoma (67%) with respect to controls (18%) was observed (p less than 0.001). The heterochromatic variants preferentially involved in both pathologies were inv(1), 1qh-, and inv(9), compared with controls. No differences were found between colon adenomas and carcinomas. We suggest that 1qh- and inv(1) variants are important heterochromatic changes in neoplasia.
authors.affiliation: Centro Austral de Investigaciones Cientificas (CADIC), Tierra del Fuego, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Labal de Vinuesa
authors.forename: M
authors.initials: M
authors.lastname: Mudry de Pargament
authors.forename: I
authors.initials: I
authors.lastname: Slavutsky
authors.forename: R
authors.initials: R
authors.lastname: Meiss
authors.forename: N
authors.initials: N
authors.lastname: Chopita
authors.forename: I
authors.initials: I
authors.lastname: Larripa
mesh_terms: D000236:Adenoma / Q000235:genetics*; D002277:Carcinoma / Q000235:genetics*; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D002899:Chromosomes, Human, Pair 9; D003110:Colonic Neoplasms / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers