title: Rolipram versus imipramine in inpatients with major, "minor" or atypical depressive disorder: a double-blind double-dummy study aimed at testing a novel therapeutic approach.
abstract: Unlike conventional antidepressants, rolipram stimulates both the presynaptic as well as the postsynaptic component of monoaminergic transmission. Several double-blind comparative trials are on the way to assess the clinical efficacy and safety of this novel compound. The present study was a randomized double-blind double-dummy comparison with imipramine in inpatients with major, "minor" and atypical depressions (DSM III). Results show no relevant differences between rolipram and imipramine regarding efficacy and safety.
authors.affiliation: Psychiatric Hospital Bisceglie, University of Bari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bertolino
authors.forename: D
authors.initials: D
authors.lastname: Crippa
authors.forename: S
authors.initials: S
authors.lastname: di Dio
authors.forename: K
authors.initials: K
authors.lastname: Fichte
authors.forename: G
authors.initials: G
authors.lastname: Musmeci
authors.forename: V
authors.initials: V
authors.lastname: Porro
authors.forename: V
authors.initials: V
authors.lastname: Rapisarda
authors.forename: M
authors.initials: M
authors.lastname: Sastre-y-Hernández
authors.forename: M
authors.initials: M
authors.lastname: Schratzer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006760:Hospitalization; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011760:Pyrrolidinones / Q000627:therapeutic use*; D020889:Rolipram
chemical_list: D000928:Antidepressive Agents; D011760:Pyrrolidinones; D020889:Rolipram; D007099:Imipramine