Penetration of fleroxacin into maxillary sinus mucosa and palatine tonsil.
Ten patients undergoing tonsillectomy or operation on the maxillary-antrum were given 200 mg fleroxacin orally 1-2 h before surgery. The concentration of fleroxacin in maxillary sinus mucosa (mean 2.61 mg/kg) was similar to that in serum samples collected simultaneously (mean 2.46 mg/l); and similar results were obtained with tonsillar tissue (mean 3.27 mg/kg; simultaneous serum samples, mean 2.84 mg/l).
Baba
S
S
Department of Otorhinolaryngology, Nagoya City University Medical School, Japan.
Mori
Y
Y
Maruo
T
T
D000890:Anti-Infective Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D016576:Fleroxacin; D006801:Humans; D008443:Maxillary Sinus / Q000378:metabolism*; D009092:Mucous Membrane / Q000378:metabolism; D014066:Palatine Tonsil / Q000378:metabolism*; D011292:Premedication; D014068:Tonsillectomy
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D016576:Fleroxacin