Circadian rhythm of ketone bodies in the blood of fasting rats.
SPF male Wistar rats were kept under standard conditions with a light: dark schedule of 12:12 h. The total ketone body concentration was determined in the blood, and the non-esterified fatty acid level in the serum, of fed rats and of animals which had fasted 24 and 48 h. The amount of ketone bodies in fed rats rose in the second half of the light period and fell with the onset of the dark period. After a 24 h fast, the amount of ketone bodies in the blood rose, but the basic characteristics of the curve and the rhythm remained the same as in fed animals. After a 48 h fast, the mean ketone body concentration was decoupled, a significant phase shift occurred and the rhythm was lost. No relationship between the oscillations of the total ketone body concentration in the blood and the oscillations of the serum non-esterified fatty acid level was found.
Ahlersová
E
E
Ahlers
I
I
Benninghausová
Z
Z
Toropila
M
M
Datelinka
I
I
D000818:Animals; D002940:Circadian Rhythm; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007657:Ketone Bodies / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005230:Fatty Acids, Nonesterified; D007657:Ketone Bodies