title: In vivo and in vitro anti-tumour activity of dimaprit.
abstract: Dimaprit, a histamine H2-receptor agonist, injected daily i.p. to fibrosarcoma-bearing mice, induced a decrease in tumour growth and an increase in survival. Dimaprit, added to tumour cell cultures (10(-4) M), inhibited the incorporation of 3H-thymidine while embryonic cell cultures were unaffected. This particular anti-tumour activity is probably H2-independent as histamine and impromidine have no effect on tumour cell cultures.
authors.forename: A
authors.initials: A
authors.lastname: Fray
authors.forename: C
authors.initials: C
authors.lastname: Burtin
authors.forename: P
authors.initials: P
authors.lastname: Scheinmann
authors.forename: G
authors.initials: G
authors.lastname: Lespinats
authors.forename: P
authors.initials: P
authors.lastname: Canu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D017259:Dimaprit; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000473:pathology; D011968:Receptors, Histamine / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D013890:Thiourea / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D013890:Thiourea; D017259:Dimaprit