title: Clinical and chemical properties of a novel mucosal bioadhesive agent.
abstract: Through clinical observations and known chemical properties, this series of studies delineates properties of a new bioadhesive agent available commercially (Zilactin). Using a previously published protocol, we determined that the duration of the film formed on mucosa was not altered after exposure to extremes in temperatures encountered in drinking hot and cold liquids. In addition, through dissection of the agent into several component parts, we were able to determine a specific role for each of the acidic ingredients. It is clear that the solubility of hydroxypropyl cellulose (Klucel) is altered by esterification of the polymer by tannic and salicylic acids and that boric acid effectively crosslinks these to form Zilactin's characteristic clinical film. Other fine points of the chemical reactions are detailed. These studies are intended to serve as a foundation for the future manipulation and application of this agent in oral mucosal diseases.
authors.affiliation: Department of Diagnostic Sciences, University of Alabama School of Dentistry, Wilmington.
authors.forename: B
authors.initials: B
authors.lastname: Rodu
authors.forename: C M
authors.initials: CM
authors.lastname: Russell
authors.forename: A J
authors.initials: AJ
authors.lastname: Desmarais
mesh_terms: D000268:Adhesiveness; D000269:Adhesives; D001672:Biocompatible Materials; D001888:Boric Acids; D002482:Cellulose / Q000031:analogs & derivatives*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D047348:Hydrolyzable Tannins; D008422:Materials Testing; D009061:Mouth Mucosa; D014677:Pharmaceutical Vehicles; D012459:Salicylates; D012995:Solubility; D013997:Time Factors
chemical_list: D000269:Adhesives; D001672:Biocompatible Materials; D001888:Boric Acids; D047348:Hydrolyzable Tannins; D014677:Pharmaceutical Vehicles; D012459:Salicylates; D002482:Cellulose; C008079:hydroxypropylcellulose; C032688:boric acid