Mood response to methylphenidate and the Dexamethasone Suppression Test as predictors of treatment response to zimelidine and lithium in major depression.
Sixteen patients with a major depressive disorder underwent a Dexamethasone Suppression Test, and 15 of these patients were given intravenous methylphenidate and their mood response recorded. There was no association between the Dexamethasone Suppression Test and mood response to methylphenidate. Neither of these markers predicted clinical antidepressant response with zimelidine, although among zimelidine nonresponders, a clinical improvement upon the addition of lithium was predicted by a positive mood response to methylphenidate.
Joyce
P R
PR
D000293:Adolescent; D000328:Adult; D000339:Affect / Q000187:drug effects; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D003907:Dexamethasone; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008094:Lithium / Q000627:therapeutic use*; D016651:Lithium Carbonate; D008297:Male; D008774:Methylphenidate; D008875:Middle Aged; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D015031:Zimeldine / Q000627:therapeutic use*
D008774:Methylphenidate; D016651:Lithium Carbonate; D015031:Zimeldine; D003907:Dexamethasone; D008094:Lithium; D006854:Hydrocortisone