title: L-656,575 (OCP-9-176): a novel oxacephem. In vitro activity against aerobic and anaerobic clinical bacterial isolates.
abstract: L-656,575 (OCP-9-176) is a novel oxacephem superior to ceftazidime in in vitro activity against clinical isolates of Enterobacter species, methicillin-susceptible Staphylococcus aureus and Staphylococcus epidermidis, and multiply-resistant Pseudomonas aeruginosa. Our results suggest that L-656,575 has a high affinity for penicillin binding proteins of Pseudomonas and may bind preferentially to PBP-3 in this organism. L-656,575 is active against beta-lactamase derepressed Enterobacteriaceae and ceftazidime-resistant P. aeruginosa.
authors.affiliation: Department of Basic Microbiology, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065-0900.
authors.forename: B
authors.initials: B
authors.lastname: Weissberger
authors.forename: G K
authors.initials: GK
authors.lastname: Abruzzo
authors.forename: R A
authors.initials: RA
authors.lastname: Fromtling
authors.forename: M E
authors.initials: ME
authors.lastname: Valiant
authors.forename: D L
authors.initials: DL
authors.lastname: Shungu
authors.forename: H H
authors.initials: HH
authors.lastname: Gadebusch
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001420:Bacteria, Aerobic / Q000187:drug effects*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D002511:Cephalosporins; D007769:Lactams; D051379:Mice; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D007769:Lactams; C057304:L 656575