[Use of a cloned alphoid repetitive sequence of human DNA in studying the polymorphism of heterochromatin regions of chromosomes].
Chromosomal location of the cloned fragment pHS05 of alphoid DNA from the collection of human PstI restricts has been studied in 38 individuals by in situ hybridization. Pericentromeric localization of the DNA fraction studied was found in practically all chromosomes of the set. Significant interchromosomal and poorly expressed interindividual differences were detected in a number of the copies of the sequence class investigated. The majority of the label (approx. 27%) was observed over the pericentromeric region of chromosome 3. No relationship was discovered between hybridization results and the pattern of Q-polymorphism.
Kruminia
A R
AR
Kroshkina
V G
VG
Iurov
Iu B
IuB
Aleksandrov
I A
IA
Mitkevich
S P
SP
D000293:Adolescent; D000328:Adult; D002871:Chromosome Banding; D002877:Chromosomes, Human / Q000648:ultrastructure*; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics* / Q000648:ultrastructure; D005260:Female; D005819:Genetic Markers; D006570:Heterochromatin / Q000235:genetics* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D009693:Nucleic Acid Hybridization; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid
D005819:Genetic Markers; D006570:Heterochromatin; D004247:DNA
Ispol'zovanie klonirovannoĭ al'foidnoĭ povtoriaiushcheĭsia posledovatel'nosti DNK cheloveka v izuchenii polimorfizma geterokhromatinovykh raĭonov khromosom.