title: Valproate in the treatment of rapid-cycling bipolar disorder.
abstract: Six consecutive patients with rapid-cycling bipolar disorder, refractory or only minimally responsive to treatment with lithium salts and neuroleptics, including five also refractory to carbamazepine, all demonstrated a moderate or marked response to the anticonvulsant valproate. These observations suggest that valproate may represent a promising treatment alternative in this often treatment-resistant form of bipolar disorder.
authors.affiliation: Epidemiology Laboratory, McLean Hospital, Belmont, Massachusetts 02178.
authors.forename: S L
authors.initials: SL
authors.lastname: McElroy
authors.forename: P E
authors.initials: PE
authors.lastname: Keck
authors.forename: H G
authors.initials: HG
authors.lastname: Pope
authors.forename: J I
authors.initials: JI
authors.lastname: Hudson
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012569:Schizotypal Personality Disorder / Q000188:drug therapy; D014635:Valproic Acid / Q000627:therapeutic use*
chemical_list: D014635:Valproic Acid