Effect of vitamin E deficiency on neurologic function in patients with cystic fibrosis.
We evaluated neurologic function in 18 patients, ages 5 to 26 years, with cystic fibrosis. Eight were deficient in vitamin E. Sural nerve conduction latency was increased and nerve action potential amplitude decreased in the vitamin E-deficient group in comparison with the vitamin E-sufficient group. Two vitamin E-deficient patients had absent deep tendon reflexes; findings of clinical neurologic examinations were otherwise normal. We recommend early supplementation with vitamin E for patients with cystic fibrosis who have pancreatic insufficiency, to prevent neurologic dysfunction.
Cynamon
H A
HA
Department of Pediatrics, University of Florida, Gainesville 32610.
Milov
D E
DE
Valenstein
E
E
Wagner
M
M
D000200:Action Potentials; D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001647:Bile Acids and Salts / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000503:physiopathology*; D006801:Humans; D009420:Nervous System / Q000503:physiopathology*; D012018:Reflex / Q000502:physiology; D013497:Sural Nerve / Q000503:physiopathology; D014811:Vitamin E Deficiency / Q000503:physiopathology*
D001647:Bile Acids and Salts; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase