[NK activity in C57BL/Ka mice during the development of radiation-induced lymphomas].
Treatment of C57BL/Ka mice with a split dose wholebody irradiation (four weekly irradiations of 1,75 Gy) induces the development of thymic lymphomas. NK activity of spleen cells has been determined at several intervals after leukemogenic treatment. Two days after irradiations. NK activity is normal and decreases strongly after one week. This period of decline persists during about one month. Then, NK activity restores and reaches control values. Lymphomas appear in spite of NK activity restoration. The diminution of NK activity during the preleukemic period could favour preleukemic cells apparition.
Noël
A
A
Schaaf-Lafontaine
N
N
Defresne
M P
MP
Boniver
J
J
D000818:Animals; D005260:Female; D007694:Killer Cells, Natural / Q000276:immunology / Q000528:radiation effects*; D008223:Lymphoma / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009381:Neoplasms, Radiation-Induced / Q000276:immunology*; D011289:Preleukemia / Q000473:pathology; D013953:Thymus Neoplasms / Q000276:immunology*; D013997:Time Factors
Activité NK chez la souris C57BL/Ka au cours du développement des lymphomes radio-induits.