title: In vitro susceptibility of Alcaligenes denitrificans subsp. xylosoxidans to 24 antimicrobial agents.
abstract: The in vitro susceptibilities of 37 clinical isolates of Alcaligenes denitrificans subsp. xylosoxidans to 24 antimicrobial agents were determined. Imipenem was the only drug with consistent activity (MIC for 90% of isolates, 2 micrograms/ml). Piperacillin, ticarcillin-clavulanic acid, ceftazidime, and co-trimoxazole were active against most strains. All the isolates were resistant to ampicillin, cefazolin, cefuroxime, cefamandole, cefotetan, ceftriaxone, cefotaxime, aztreonam, amdinocillin, and temocillin. Most isolates were resistant to the aminoglycosides tested, including amikacin. Lack of activity was also observed for all new 4-quinolone antimicrobial agents.
authors.affiliation: Department of Clinical Microbiology, Brugmann University Hospital, Brussels, Belgium.
authors.forename: Y
authors.initials: Y
authors.lastname: Glupczynski
authors.forename: W
authors.initials: W
authors.lastname: Hansen
authors.forename: J
authors.initials: J
authors.lastname: Freney
authors.forename: E
authors.initials: E
authors.lastname: Yourassowsky
mesh_terms: D000421:Alcaligenes / Q000187:drug effects*; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D015378:Imipenem; D013845:Thienamycins / Q000494:pharmacology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D013845:Thienamycins; D015378:Imipenem