Hepatitis A virus and non-A, non-B virus superinfections in HBsAg chronic carriers.
Clinical course, morphologic changes, immunohistochemical localization of HBV-associated markers (HBsAg, HBcAg), and serum HBV-DNA production are described in 2 chronic HBsAg carriers superinfected with HAV and hepatitis non-A, non-B virus. Our data suggest that the superinfections do not cause more severe disease and do not influence the clinical course of the HBsAg chronic carriers. Our observations indicate that a careful diagnosis of hepatocytolysis is necessary in HBV chronic infection, in order to discriminate causes that are able to induce severe damage in underlying disease.
Sansonno
D E
DE
Laboratory of Liver Immunopathology, Istituto di Ricovero e Cura a Carattere Scientifico, Castellana Grotte, Bari, Italy.
Fiore
G
G
Pietropaolo
F
F
Avellis
D
D
Napoli
N
N
Manghisi
O G
OG
D000328:Adult; D002353:Carrier State / Q000473:pathology*; D004279:DNA, Viral / Q000032:analysis; D006506:Hepatitis A / Q000473:pathology*; D006509:Hepatitis B / Q000473:pathology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006526:Hepatitis C / Q000473:pathology*; D006521:Hepatitis, Chronic / Q000473:pathology*; D006525:Hepatitis, Viral, Human / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008099:Liver / Q000473:pathology; D008297:Male; D015163:Superinfection / Q000473:pathology*
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens