Radioimmunoassay artifact associated with circulating anti-rabbit antibodies.
A 30 year old woman presenting with infertility was found to have elevated serum immunoreactive prolactin, TSH and total T3. These findings were eventually attributed to assay artifact when she was shown to have anti-rabbit antibodies in her serum. The possibility of laboratory artifact should be considered in clinical practice when abnormal immunoassay results are unsupported by clinical or radiographic data.
Jeffcoate
W J
WJ
City Hospital, Nottingham, UK.
Selby
C
C
Powell
R J
RJ
D000328:Adult; D000818:Animals; D000906:Antibodies / Q000032:analysis*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000276:immunology*; D011388:Prolactin / Q000276:immunology; D011817:Rabbits; D011863:Radioimmunoassay; D013972:Thyrotropin / Q000276:immunology; D014284:Triiodothyronine / Q000276:immunology
D000906:Antibodies; D014284:Triiodothyronine; D011388:Prolactin; D013972:Thyrotropin