[Comparative analysis of the levels of anti-prostaglandin F2 alpha antibodies in the normal state and in cardiovascular diseases].
The ELISA test was performed on sera of normal donors and patients with myocardial infarction (MI) and essential hypertension (EH) to detect autoantibodies against prostaglandin F2 alpha (a-PGF2 alpha). The a-PGF2 alpha level was much higher after immune complexes dissociation. Baseline a-PGF2 alpha was elevated in EH patients with a sudden rise in blood pressure, and in MI patients without hypertension and unstable angina. MI patients with bradyarrhythmias also had elevated a-PGF2 alpha levels. Baseline a-PGF2 alpha was rather low in the sera of donors, chronic EH patients with hypertension and unstable angina, suggesting that a-PGF2 alpha has a physiological role to play.
Korochkin
I M
IM
Verbitskaia
I A
IA
Elkonin
A B
AB
Krupnik
V E
VE
Polevaia
O Iu
OIu
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D015237:Dinoprost; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D006973:Hypertension / Q000276:immunology*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000276:immunology*; D011460:Prostaglandins F / Q000276:immunology*; D012016:Reference Values
D001323:Autoantibodies; D011460:Prostaglandins F; D015237:Dinoprost
Sravnitel'nyĭ analiz soderzhaniia autoantitel protiv prostaglandina F2 alpha v norme i pri serdechno-sosudistykh zabolevaniiakh.