title: Locus affecting regulation of the colicin I receptor by iron.
abstract: Using a strain containing a cir-lac operon fusion and a selective medium, we isolated a regulatory mutant of the colicin I receptor, which we have designated cirR. Cells carrying the cirR mutation were defective in the transcriptional regulation of cir by iron, but synthesis of other iron-regulated proteins was unaffected. cirR was found to be cis dominant. This is in contrast to previously described mutations in iron regulation which are pleiomorphic and trans dominant. Temperature regulation of colicin I receptor production was unaffected by cirR.
authors.forename: P L
authors.initials: PL
authors.lastname: Worsham
authors.forename: J
authors.initials: J
authors.lastname: Konisky
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis; D004758:Enterobactin / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics*; D029968:Escherichia coli Proteins; D007501:Iron / Q000494:pharmacology*; D007763:Lac Operon; D008565:Membrane Proteins / Q000096:biosynthesis; D009154:Mutation; D009876:Operon; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic / Q000187:drug effects / Q000235:genetics*; D013696:Temperature; D014158:Transcription, Genetic; D014161:Transduction, Genetic
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; C028593:colicin receptor, E coli; D004758:Enterobactin; D007501:Iron