title: Effect of lipid peroxidation on heart mitochondria oxygen consuming and calcium transporting capacities.
abstract: The incubation of rabbit heart mitochondria in the presence of ferrous ions induced lipid peroxidation which was accompanied by a reduction of mitochondrial respiratory capacity and Ca++ transport. The effects were more evident, when pyruvate was employed as respiratory substrate, and were partially prevented by catalase, while superoxide dismutase was ineffective.
authors.affiliation: Universitá degli Studi di Brescia, Cattedra di Cardiologia e di Chimica, Brescia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Ceconi
authors.forename: S
authors.initials: S
authors.lastname: Curello
authors.forename: A
authors.initials: A
authors.lastname: Albertini
authors.forename: R
authors.initials: R
authors.lastname: Ferrari
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002374:Catalase / Q000494:pharmacology; D005296:Ferrous Compounds / Q000494:pharmacology; D005609:Free Radicals; D015227:Lipid Peroxidation; D008929:Mitochondria, Heart / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D011773:Pyruvates / Q000494:pharmacology; D011817:Rabbits; D013482:Superoxide Dismutase / Q000494:pharmacology
chemical_list: D005296:Ferrous Compounds; D005609:Free Radicals; D011773:Pyruvates; D002374:Catalase; D013482:Superoxide Dismutase; D002118:Calcium