[Mitotic activity of rat bone marrow cells during injury].
The mitotic regimen analysis in rat bone marrow cells was conducted 1, 3, 7, 14, 21 and 35 days after shock trauma. A sharp impairment of myelocyte reproductive function was registered against an increase in the mitotic index. It confirms a universal character of normal mitosis impairment in strong stresses, which was earlier established for epithelial tissues. Cell division disturbances in the bone marrow may be considered an pathogenic factor of a number of pathological processes occurring in the blood system in traumatic disease (anemia, immunodepression). A complex of drugs (sodium oxybutyrate, sodium oxiferriscarbon, Laevamizolum) is offered for the correction of proliferative processes in the bone marrow. This complex has no significant influence on mitotic index and causes relative reduction of pathological mitosis level, ensuring its earlier normalization.
Red'kin
Iu V
IuV
Miroshnik
O A
OA
D015083:2,3-Diketogulonic Acid / Q000494:pharmacology; D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D004338:Drug Combinations / Q000494:pharmacology; D005290:Ferric Compounds / Q000494:pharmacology; D007978:Levamisole / Q000494:pharmacology; D008297:Male; D008938:Mitosis / Q000187:drug effects; D008940:Mitotic Index / Q000187:drug effects; D051381:Rats; D012774:Shock, Traumatic / Q000188:drug therapy / Q000473:pathology*; D012978:Sodium Oxybate / Q000494:pharmacology
D004338:Drug Combinations; D005290:Ferric Compounds; D007978:Levamisole; D015083:2,3-Diketogulonic Acid; C008747:oxyferriscorbone; D000496:Alloxan; D012978:Sodium Oxybate
Mitoticheskiĭ rezhim kletok kostnogo mozga krys v dinamike travmaticheskoĭ bolezni.