title: Observations on the effects of some antiaggregating drugs on platelet specific protein discharge after a very weak stimulus.
abstract: Platelet adhesion, aggregation, secretion, and survival have been shown to be changed in atherosclerosis disease and thromboembolic phenomena thus further increasing interest on antiaggregating drugs. In this paper we present some evidence that 8-chlorocarbochromen and carbochromen are significantly effective in preventing the discharge of platelet specific proteins from platelets subjects to a very weak stimulus while acetylsalicylic acid and aminophylline are ineffective in this regard.
authors.forename: G
authors.initials: G
authors.lastname: Weber
authors.forename: G
authors.initials: G
authors.lastname: Bianciardi
authors.forename: P
authors.initials: P
authors.lastname: Toti
authors.forename: P
authors.initials: P
authors.lastname: Massari
authors.forename: P
authors.initials: P
authors.lastname: Orlando
mesh_terms: D000628:Aminophylline / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects; D002866:Chromonar / Q000031:analogs & derivatives / Q000494:pharmacology; D003374:Coumarins / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D010978:Platelet Factor 4 / Q000037:antagonists & inhibitors; D010982:Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors; D001620:beta-Thromboglobulin / Q000037:antagonists & inhibitors
chemical_list: D003374:Coumarins; D010982:Platelet-Derived Growth Factor; D001620:beta-Thromboglobulin; D000628:Aminophylline; D010978:Platelet Factor 4; C025945:cloricromen; D002866:Chromonar; D001241:Aspirin