Haemolytic uraemic syndrome associated with faecal cytotoxin and verotoxin neutralizing antibodies.
Forty-nine patients with a diagnosis of idiopathic haemolytic uraemic syndrome (HUS) were investigated to determine evidence of infection by verotoxin-producing Escherichia coli (VTEC). Free faecal cytotoxin active on Vero cells (VT) was detected in 15 out of 49 patients (31%). Seroconversion or high titres of VT-neutralizing antibodies were detected in 11 out of 18 patients (61%). The results of the present study suggest an association between HUS and infection by VTEC.
Novillo
A A
AA
Department of Virology and Bacteriology, Instituto Nacional de Microbiología Carlos G. Malbrán, Buenos Aires, Argentina.
Voyer
L E
LE
Cravioto
R
R
Freire
M C
MC
Castaño
G
G
Wainstein
R
R
Binztein
N
N
D000907:Antibodies, Bacterial; D001427:Bacterial Toxins / Q000276:immunology*; D002675:Child, Preschool; D003603:Cytotoxins / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D004927:Escherichia coli Infections / Q000150:complications / Q000276:immunology; D005243:Feces / Q000382:microbiology; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000150:complications / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D009500:Neutralization Tests; D022622:Shiga Toxin 1
D000907:Antibodies, Bacterial; D001427:Bacterial Toxins; D003603:Cytotoxins; D022622:Shiga Toxin 1