title: [Cardiac transplantation at the University Hospital Center of Nantes. 2 years' experience].
abstract: Between March, 1985 and April, 1987, 25 orthotopic heart transplantations were performed in 20 men and 5 women aged from 17 to 58 years (mean 42 years) on account of cardiomyopathy (n = 15), ischaemic heart disease (n = 6) or miscellaneous lesions (n = 4). The immunosuppressive treatment consisted of antilymphocyte serum and corticosteroids during 10 days; cyclosporine was introduced on the 7th day and continued thereafter in association with low-dose corticosteroid therapy. Endomyocardial biopsies were performed. Acute rejection, responsible for 2 deaths (one on the 10th day, the other in the 10th week), usually occurred within the first 3 months. Infections were frequent and often serious, resulting in one death in the 7th week. One out of patients had to be treated for arterial hypertension, and 3 patients presented with renal impairment (blood creatinine over 200 mumoles/l). The actuarial survival rate at 2 years is 84 p. 100. More than one-half of the patients have resumed social and occupational activities.
authors.affiliation: Service de cardiologie, hôpital Laënnec, Nantes.
authors.forename: T
authors.initials: T
authors.lastname: Petit
authors.forename: M
authors.initials: M
authors.lastname: Train
authors.forename: M
authors.initials: M
authors.lastname: Treilhaud
authors.forename: A Y
authors.initials: AY
authors.lastname: de Lajartre
authors.forename: J L
authors.initials: JL
authors.lastname: Michaud
authors.forename: P
authors.initials: P
authors.lastname: Despins
authors.forename: D
authors.initials: D
authors.lastname: Duveau
authors.forename: D
authors.initials: D
authors.lastname: Portier
authors.forename: J F
authors.initials: JF
authors.lastname: Godin
authors.forename: H
authors.initials: H
authors.lastname: Petitier
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D009202:Cardiomyopathies / Q000628:therapy; D002985:Clinical Protocols; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006086:Graft vs Host Disease; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents
vernacular_title: Transplantation cardiaque au CHU de Nantes. Deux ans d'expérience.