Is waning of a 5-hydroxytryptamine (5-HT)-mediated syndrome due to 5-HT2 receptor down-regulation?
The 5-hydroxytryptamine (5-HT) uptake inhibitor, paroxetine (11.6 mg/kg i.p.), given to rats pretreated with the monoamine oxidase inhibitor, phenelzine, 18 h (46.8 mg/kg i.p.) and 90 min (11.7 mg/kg i.p.) before, evoked a 5-HT-dependent syndrome which included wet-dog shakes (WDS). The frequency of WDS declined over the ensuing 3 h, at which time cortical 5-HT2 receptors showed a significant (30%) decrease in number. A second injection of paroxetine given at this time did not evoke a significant increase in the number of WDS, suggesting that spinal 5HT2 receptors might also have been down-regulated at the same time.
Koshikawa
N
N
Smokcum
R W
RW
Stephenson
J D
JD
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D007650:Ketanserin; D008297:Male; D009207:Myoclonus / Q000139:chemically induced / Q000503:physiopathology*; D017374:Paroxetine; D010624:Phenelzine; D010880:Piperidines / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000378:metabolism / Q000502:physiology*; D012701:Serotonin / Q000502:physiology*; D013577:Syndrome; D013997:Time Factors; D014316:Tritium
D010880:Piperidines; D011985:Receptors, Serotonin; D014316:Tritium; D012701:Serotonin; D017374:Paroxetine; D007650:Ketanserin; D010624:Phenelzine