Use of hyperthermia and radiotherapy in treatment of a large mast cell sarcoma in a dog.
A large infiltrating mast cell sarcoma in a dog, which had been refractory before surgical excision, was controlled 2 months after completion of a combined radiotherapy and hyperthermia regimen. Treatment resulted in rapid tumor necrosis and resultant ulceration of adjacent skin. Ulceration was transient, resolving concurrently with tumor control. Radiation was administered as 3.5-Gy fractions 3 times/week, resulting in a total dose of 45.5 Gy in 13 treatments. Hyperthermia (44 C for 30 minutes) was given 4 to 5 hours after radiotherapy, once a week during the first 3 weeks of treatment.
Legorreta
R A
RA
Division of Radiation Oncology, College of Medicine, University of Cincinnati Hospital, OH 45267-0757.
Denman
D L
DL
Kelley
M C
MC
Lewis
G C
GC
D000818:Animals; D003131:Combined Modality Therapy; D004283:Dog Diseases / Q000532:radiotherapy / Q000628:therapy*; D004285:Dogs; D005121:Extremities; D005260:Female; D006979:Hyperthermia, Induced / Q000662:veterinary*; D012515:Mast-Cell Sarcoma / Q000532:radiotherapy / Q000628:therapy / Q000662:veterinary*; D012878:Skin Neoplasms / Q000532:radiotherapy / Q000628:therapy / Q000662:veterinary*