Idiotypic-antiidiotypic interactions in man.
Anti-idiotypic (anti-Id) antibodies are directed against antigenic determinants expressed by the antigen-binding region of the immunoglobulin molecules. Their interaction with antigen receptors on immune cells modulates the immune response. In man auto-anti-Id antibodies have been demonstrated. These antibodies not only participate in the regulation of the immune response, but can result in disease as in the case of acquired angioedema with B cell malignancy and possibly in autoimmune diseases. Anti-Id antibodies may be useful tools in cancer immunotherapy and in the production of vaccines.
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D000799:Angioedema / Q000276:immunology; D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000276:immunology; D005260:Female; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007167:Immunotherapy; D007340:Insulinoma / Q000276:immunology; D016030:Kidney Transplantation; D009369:Neoplasms / Q000628:therapy; D011247:Pregnancy
D007130:Immunoglobulin Idiotypes