Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin papillomas and carcinomas by dehydroepiandrosterone and 3-beta-methylandrost-5-en-17-one in mice.
Topical application of the adrenal steroid, dehydroepiandrosterone, or the synthetic steroid, 3-beta-methylandrost-5-en-17-one, which unlike dehydroepiandrosterone is not demonstrably uterotrophic, inhibits 7,12-dimethylbenz(a)anthracene-induced skin papillomas and carcinomas in the CD-1 mouse.
Pashko
L L
LL
Hard
G C
GC
Rovito
R J
RJ
Williams
J R
JR
Sobel
E L
EL
Schwartz
A G
AG
D015127:9,10-Dimethyl-1,2-benzanthracene; D000287:Administration, Topical; D000736:Androstenes / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents; D003687:Dehydroepiandrosterone / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy*
D000736:Androstenes; D000970:Antineoplastic Agents; D003687:Dehydroepiandrosterone; D015127:9,10-Dimethyl-1,2-benzanthracene; C040993:3-methylandrost-5-en-17-one