Overlap of granulomatous vasculitis and sarcoidosis: presentation with uveitis, eosinophilia, leg ulcers, sinusitis, and past foot drop.
A 24-year-old black woman with a history of pulmonary and hepatic sarcoidosis followed by foot drop presented with uveitis, eosinophilia, leg ulcers, and sinus opacification. Biopsy of the leg ulcer and review of the past lung biopsy revealed numerous epithelioid noncaseating granulomas and granulomatous vasculitis. Although her clinical presentation raised the possibility of Wegener's granulomatosis, the many discrete granulomas and lack of necrosis on her biopsies were more in favor of sarcoidosis. Although granulomatous vasculitis has been reported as part of necrotizing sarcoid granulomatosis, our patient was unique in the extent and type of her extrapulmonary symptomatology.
Petri
M
M
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205.
Barr
E
E
Cho
K
K
Farmer
E
E
D000328:Adult; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000175:diagnosis; D005260:Female; D006099:Granuloma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007866:Leg; D007871:Leg Ulcer / Q000175:diagnosis*; D010243:Paralysis / Q000175:diagnosis; D012507:Sarcoidosis / Q000175:diagnosis* / Q000473:pathology; D012852:Sinusitis / Q000175:diagnosis; D014605:Uveitis / Q000175:diagnosis*; D014652:Vascular Diseases / Q000175:diagnosis*; D014657:Vasculitis / Q000175:diagnosis* / Q000473:pathology