Non-A, non-B hepatitis-related hepatocellular carcinoma in a chimpanzee.
Epidemiology has indicated the possible association of non-A, non-B hepatitis (NANBH) with hepatocellular carcinoma (HCC) in man, but there are no means for confirmation. Chimpanzees are recognized models for studying hepatitis B and NANBH, and may become carriers of both. The first case of HCC to be reported in chimpanzees was found after longitudinal study of a hepatitis B-free chimpanzee 7 years after inoculation with human plasma from a patient reported to have chronic NANBH.
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Laboratory for Experimental Medicine and Surgery in Primates (LEMSIP) New York University Medical Center, Tuxedo 10987.
Popper
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Peterson
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Miller
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Lieberman
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HM
D000818:Animals; D004195:Disease Models, Animal; D006526:Hepatitis C / Q000150:complications* / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000150:complications*; D008113:Liver Neoplasms / Q000209:etiology*; D008114:Liver Neoplasms, Experimental / Q000209:etiology*; D008137:Longitudinal Studies; D008854:Microscopy, Electron; D002679:Pan troglodytes