title: Comparison of meclofenamate sodium and hydrocortisone for controlling the postsurgical inflammatory response in rats.
abstract: The effectiveness of meclofenamate sodium and hydrocortisone in alleviation of local postsurgical swelling and leukocytic infiltration was compared at two postsurgical intervals in 60 male Sprague-Dawley rats. Both drugs were effective at 24 hours after surgery. Ten doses of 2 mg meclofenamate sodium administered over a 5-day period were more effective in reducing leukocytic infiltration than six doses of 2 mg hydrocortisone administered over the same period. Neither the hydrocortisone nor the meclofenamate sodium at the dosage used adversely affected osteoid formation.
authors.affiliation: Indian University Medical Center, School of Dentistry, Indianapolis.
authors.forename: H L
authors.initials: HL
authors.lastname: Shieh
authors.forename: C E
authors.initials: CE
authors.lastname: Hutton
authors.forename: A H
authors.initials: AH
authors.lastname: Kafrawy
authors.forename: R H
authors.initials: RH
authors.lastname: Potter
mesh_terms: D000818:Animals; D006854:Hydrocortisone / Q000008:administration & dosage* / Q000627:therapeutic use; D007249:Inflammation / Q000517:prevention & control*; D008297:Male; D008469:Meclofenamic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D014945:Wound Healing / Q000187:drug effects*; D062367:ortho-Aminobenzoates / Q000008:administration & dosage*
chemical_list: D062367:ortho-Aminobenzoates; D008469:Meclofenamic Acid; D006854:Hydrocortisone