Intracellular mechanisms of contraction in the hypertensive and normotensive rat aortas.
The roles of intracellular mechanisms of contraction were compared in aortas from genetically hypertensive and normotensive rats by investigating the contractile activities of prostaglandin F2 alpha (PGF2 alpha) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in the absence of extracellular calcium. PGF2 alpha induced a greater amount of tension in aortic strips from hypertensive than normotensive rats. Furthermore, in hypertensive but not normotensive rat aortas, PGF2 alpha- and TPA-induced contractions were additive and were capable of sustaining a near maximum degree of muscle activation. Therefore, the intracellular contractile mechanisms in hypertensive vascular tissue may differ from those in normotensive tissue.
Heaslip
R J
RJ
Division of Immunopharmacology, Wyeth-Ayerst Laboratories, Princeton, NY 08543-8000.
Sickels
B D
BD
D000818:Animals; D001011:Aorta / Q000503:physiopathology; D015237:Dinoprost; D006973:Hypertension / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000502:physiology*; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D011460:Prostaglandins F; D015237:Dinoprost; D013755:Tetradecanoylphorbol Acetate