title: Pseudomonas aeruginosa and the airways disease of cystic fibrosis.
abstract: The gram-negative organism Pseudomonas aeruginosa plays a major role in the morbidity and mortality of patients with cystic fibrosis (CF). Inherent properties of this organism, together with alterations in the CF airway, lead to colonization of the CF patient and, ultimately, contribute to the destructive lung lesion of CF. Innovative antibiotic therapies for the CF patient are discussed, including new potent oral and parenteral pseudomonicidal antibiotics, the re-emergence of nebulized delivery systems, and the validation of home intravenous therapy.
authors.affiliation: University of Iowa College of Medicine, Iowa City.
authors.forename: J S
authors.initials: JS
authors.lastname: Hata
authors.forename: R B
authors.initials: RB
authors.lastname: Fick
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001991:Bronchitis / Q000150:complications / Q000188:drug therapy*; D003550:Cystic Fibrosis / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D011552:Pseudomonas Infections / Q000150:complications / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents