title: Age-related change in the multiple unit activity of the rat brain parietal cortex and the effect of centrophenoxine.
abstract: In this study, spontaneous multiple unit activity (MUA, action potentials derived simultaneously from a number of neurons in a given brain region) was recorded through electrodes chronically implanted in the parietal cerebral cortex of the rats of 1, 3, 6, 9, 12, and 26 months of age (cross-sectional study). Electrophysiological recordings were obtained from unrestrained conscious rats using standard techniques. The results indicated that multiple unit activity was decreased with aging (senescence). Maximum firing rate (MUA counts) was found at the age of 3 months. At 6 months of age, the MUA was decreased by about 30%, while during 6 to 12 months of age the activity seemed to remain unchanged. At 26 months of age the firing rate was, however, further decreased (about 40%). Centrophenoxine administration led to an increase in MUA in the rats of 12 and 26 months of age. The results, thus, further showed that centrophenoxine, a nootropic drug known for its antiaging effects in experimental animals as well as in humans, also manifested beneficial effects electrophysiologically. The data presented in this work are new and significant, since although age effects on gross electrophysiological signals (EEG, evoked potentials, etc.) are known, the aging changes in cellular level electrophysiological signals (action potentials) have not been generally studied particularly in conscious animals.
authors.affiliation: Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
authors.forename: D
authors.initials: D
authors.lastname: Roy
authors.forename: R
authors.initials: R
authors.lastname: Singh
mesh_terms: D000375:Aging; D000818:Animals; D004553:Electric Conductivity; D004569:Electroencephalography; D005260:Female; D006016:Glycolates / Q000494:pharmacology*; D002504:Meclofenoxate / Q000494:pharmacology*; D010296:Parietal Lobe / Q000187:drug effects / Q000254:growth & development* / Q000502:physiology; D051381:Rats
chemical_list: D006016:Glycolates; D002504:Meclofenoxate