title: Discordant interleukin 2 production in monozygotic twins concordant for systemic lupus erythematosus.
abstract: We present data from monozygotic twins concordant for SLE. IL-2 production by peripheral blood mononuclear cells from the patients, when they were discordant for SLE activity, were measured employing cellular mixing experiments. Macrophages from active SLE had a suppressive effect on IL-2 production. Furthermore, SLE T cells appeared to have a defect in IL-2 production irrespective of disease activity. These defects might play an important role in the disordered immunoregulation in SLE.
authors.affiliation: Division of Clinical Immunology, Tokyo Women's Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: N
authors.initials: N
authors.lastname: Miyasaka
authors.forename: K
authors.initials: K
authors.lastname: Yamaoka
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Nishido
authors.forename: M
authors.initials: M
authors.lastname: Okuda
authors.forename: K
authors.initials: K
authors.lastname: Nishioka
mesh_terms: D000328:Adult; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D014430:Twins, Monozygotic
chemical_list: D007376:Interleukin-2; D015850:Interleukin-6