An analgesiometry system for use in rabbits with some preliminary data on the effects of buprenorphine and lofentanil.
A low cost infrared skin heating system has been designed to measure the efficacy of analgesics in rabbits. Following construction of a prototype, it was used to assess the effect of buprenorphine given subcutaneously and per rectum. Buprenorphine administered subcutaneously has a rapid onset of action, but its duration (8-10 h) appears slightly shorter than has been suggested previously; rectal administration appears to prolong its effect. Preliminary data show that lofentanil has a longer duration of action than buprenorphine and it may prove, therefore, to be a valuable long-acting analgesic in the rabbit.
Wootton
R
R
Divisions of Comparative Medicine and Bioengineering, MRC Clinical Research Centre, Harrow, Middlesex, UK.
Cross
G
G
Wood
S
S
West
C D
CD
D000698:Analgesia / Q000662:veterinary*; D000818:Animals; D002047:Buprenorphine / Q000008:administration & dosage; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000031:analogs & derivatives*; D007279:Injections, Subcutaneous; D007700:Kinetics; D008297:Male; D010147:Pain Measurement / Q000295:instrumentation*; D011817:Rabbits; D012007:Rectum
D002047:Buprenorphine; C034846:lofentanil; D005283:Fentanyl