Cellular immune functions in patients with primary hyperparathyroidism: effects of histamine and cimetidine.
The possibility of a link between parathyroid hyperfunction and cellular immune functions was studied in primary hyperparathyroid (1 degree HP) patients. The effect of cimetidine on lymphocyte functions in 1 degree HP patients and control subjects was also investigated. Histamine-induced suppressor activity of lymphocytes from 1 degree HP patients was significantly greater than that of controls. Cimetidine addition to both normal and 1 degree HP lymphocyte cultures abolished histamine-induced suppression. In vivo administration of cimetidine, while ineffective towards normal lymphocytes, depressed phytohemagglutinin stimulation of 1 degree HP lymphocytes, indicating possible immunological damage caused by this drug, which is frequently used in the treatment of patients with 1 degree HP.
Lahat
N
N
Glaser
B
B
Nir
E
E
Rotem
M
M
Sheinfeld
M
M
Kraiem
Z
Z
D002927:Cimetidine / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D006961:Hyperparathyroidism / Q000276:immunology*; D007111:Immunity, Cellular / Q000187:drug effects; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects
D010835:Phytohemagglutinins; D003208:Concanavalin A; D002927:Cimetidine; D006632:Histamine