title: Subacute and chronic bone infections: diagnosis using In-111, Ga-67 and Tc-99m MDP bone scintigraphy, and radiography.
abstract: The usefulness of indium-111 white blood cell scintigraphy in the diagnosis of subacute or chronic bone infection was examined in 21 orthopedic patients. In-111 WBC imaging was compared with gallium-67 and technetium-99m methylene diphosphonate skeletal scintigraphy and bone radiography, all studies being performed within 1 week. In-111 WBC scintigraphy showed no definite advantage over Ga-67 scintigraphy in the identification of chronic bone infection. The two tests had the same sensitivity (80%) and similar specificity (In-111 WBC 75%, Ga-67 83%; difference not significant). Bone radiography had a sensitivity of 60% and a specificity of 67%. A negative Tc-99m MDP bone scintigram ruled out infection (sensitivity 100%), but because of low specificity (25%), final evaluation required performance of Ga-67 or In-111 WBC scintigraphy.
authors.forename: W
authors.initials: W
authors.lastname: Al-Sheikh
authors.forename: G N
authors.initials: GN
authors.lastname: Sfakianakis
authors.forename: W
authors.initials: W
authors.lastname: Mnaymneh
authors.forename: M
authors.initials: M
authors.lastname: Hourani
authors.forename: A
authors.initials: A
authors.lastname: Heal
authors.forename: R C
authors.initials: RC
authors.lastname: Duncan
authors.forename: A
authors.initials: A
authors.lastname: Burnett
authors.forename: F S
authors.initials: FS
authors.lastname: Ashkar
authors.forename: A N
authors.initials: AN
authors.lastname: Serafini
mesh_terms: D000328:Adult; D000368:Aged; D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D002908:Chronic Disease; D004164:Diphosphonates; D005710:Gallium Radioisotopes; D006801:Humans; D007204:Indium; D007239:Infections / Q000000981:diagnostic imaging*; D007962:Leukocytes; D008875:Middle Aged; D011859:Radiography; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013667:Technetium; D013669:Technetium Tc 99m Medronate
chemical_list: D004164:Diphosphonates; D005710:Gallium Radioisotopes; D011868:Radioisotopes; D007204:Indium; D013667:Technetium; D013669:Technetium Tc 99m Medronate