Pharmacokinetics of lisuride after subcutaneous infusion.
Six parkinsonian patients received a constant subcutaneous infusion of 60 micrograms lisuride per hour in the abdominal region for 2 hours. Plasma levels of the unchanged drug were measured by radio-immunoassay. During infusion, a steady state plasma level of 0.78 +/- 0.19 ng/ml was achieved. After discontinuation of the infusion, concentrations declined with a half-life of 1.4 +/- 0.4 hour. The total clearance of lisuride was 20 +/- 6 ml/min/kg. Due to the low interpatient variability of plasma levels, a good control of clinical effects is to be expected.
Krause
W
W
Research Laboratories of Schering, Berlin, Federal Republic of Germany.
Nieuweboer
B
B
Ruggieri
S
S
Stocchi
F
F
Suchy
I
I
D000284:Administration, Oral; D001682:Biological Availability; D004873:Ergolines / Q000008:administration & dosage*; D006801:Humans; D007260:Infusion Pumps; D007263:Infusions, Parenteral; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008090:Lisuride / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D010300:Parkinson Disease / Q000097:blood / Q000188:drug therapy; D013997:Time Factors
D004873:Ergolines; D008090:Lisuride