title: Myocardial contractility and performance capacity after magnesium infusions in young healthy persons: a double-blind, placebo-controlled, cross-over study.
abstract: To evaluate the effect of intravenous magnesium (Mg) treatment on the inotropic state of the heart and maximal work capacity, 9 healthy volunteers were entered in a double-blind, placebo-controlled, cross-over study. Separated by an interval of three weeks, the volunteers were tested twice, each time randomly allocated to receive either an intravenous injection of 10 mmol magnesium chloride dissolved in 100 ml isotonic sodium chloride or placebo of isotonic sodium chloride only. Before and after each infusion myocardial inotropism was evaluated by echocardiography. Mitral-septal distance (MSA) was used as a measure for ejection fraction. On each test day an ergometer bicycle exercise test was performed, and maximal work capacity was calculated. Magnesium treatment reduced the MSA (from 4.2 to 2.9 mm, p = 0.07), while no difference was found after placebo treatment. Likewise, a tendency toward increasing fractional shortening after magnesium treatment was detected, although this difference was not statistically significant (p = 0.1). No difference in maximal work capacity between the magnesium and placebo periods was found. Serum magnesium concentrations and placebo periods was found. Serum magnesium concentrations rose significantly after the infusions (from 0.82 to 1.38 mmol/l, p less than 0.001). It is concluded that intravenous magnesium does not exert a negative inotropic effect on the myocardium as previously stated. On the contrary, we found a tendency toward a positive inotropic effect. However, the observed differences are of borderline statistical significance and a more extended study, employing invasive measurements of cardiac inotropism appears to be necessary.
authors.affiliation: Department of Cardiology, Copenhagen County Hospital, Denmark.
authors.forename: H S
authors.initials: HS
authors.lastname: Rasmussen
authors.forename: R
authors.initials: R
authors.lastname: Videbaek
authors.forename: T
authors.initials: T
authors.lastname: Melchior
authors.forename: P
authors.initials: P
authors.lastname: Aurup
authors.forename: C
authors.initials: C
authors.lastname: Cintin
authors.forename: N T
authors.initials: NT
authors.lastname: Pedersen
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D008274:Magnesium / Q000494:pharmacology*; D015636:Magnesium Chloride; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D011897:Random Allocation; D013268:Stimulation, Chemical; D013318:Stroke Volume
chemical_list: D015636:Magnesium Chloride; D008274:Magnesium