Anti-inflammatory activity of benzopyrones that are inhibitors of cyclo- and lipo-oxygenase.
The anti-inflammatory activity of three benzo-pyrones with prevalent lipooxigenase-inhibitory activity was studied using the Croton oil ear test in mice, in comparison with nordihydroguaieretic acid (NDGA) and indomethacin. Kaempferol, quercetin and NDGA possess a strong and prolonged anti-inflammatory effect, whereas the action of indomethacin appears relevant, but not long-lasting. In contrast the anti-inflammatory activity of esculetin is rather weak, but persistent.
Della Loggia
R
R
Institute of Pharmacology and Pharmacognosy, University of Trieste, Italy.
Ragazzi
E
E
Tubaro
A
A
Fassina
G
G
Vertua
R
R
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003436:Croton Oil / Q000633:toxicity; D016861:Cyclooxygenase Inhibitors; D004487:Edema / Q000188:drug therapy; D005419:Flavonoids / Q000627:therapeutic use*; D006098:Granulocytes / Q000187:drug effects; D007213:Indomethacin / Q000627:therapeutic use; D044949:Kaempferols; D016859:Lipoxygenase Inhibitors; D008297:Male; D009637:Masoprocol / Q000627:therapeutic use; D051379:Mice; D008815:Mice, Inbred Strains; D011794:Quercetin / Q000627:therapeutic use*; D014468:Umbelliferones / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D005419:Flavonoids; D044949:Kaempferols; D016859:Lipoxygenase Inhibitors; D014468:Umbelliferones; C006552:kaempferol; D009637:Masoprocol; D003436:Croton Oil; D011794:Quercetin; C007628:esculetin; D007213:Indomethacin