title: Calcium channel antagonists. Part V: Second-generation agents.
abstract: Second-generation agents include new dihydropyridines, such as amlodipine, felodipine, isradipine, nicardipine, nimodipine, nisoldipine, and nitrendipine. Verapamil-like agents include tiapamil, gallopamil, and anipamil. Among the diphenylalkylamines, bepridil is of special interest. New preparations of existing agents include slow-release formulations of nifedipine, verapamil, and diltiazem. From all these agents will be selected those that are longer-acting and provide higher vascular selectivity.
authors.affiliation: Department of Medicine, University of Cape Town, Medical School, Observatory, Republic of South Africa.
authors.forename: L H
authors.initials: LH
authors.lastname: Opie
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans
chemical_list: D002121:Calcium Channel Blockers