Nonrandom chromosomal abnormalities in malignant pleural mesothelioma.
Cytogenetic studies were performed on tumor cells from specimens of 30 consecutive patients with malignant pleural mesothelioma. Metaphases for chromosomal G-banding analyses were obtained from 27 of these patients. Clonal abnormalities were detected in 19 patients. Karyotype findings were complex and heterogeneous: aneuploidy, polyploidy, structural abnormalities, and several subclones were seen. The most frequent chromosomal abnormalities were polysomy or partial polysomy 7, monosomy or partial monosomy 22, and rearrangements involving breakpoints at 1p11-22.
Tiainen
M
M
Department of Medical Genetics, University of Helsinki, Finland.
Tammilehto
L
L
Mattson
K
K
Knuutila
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D008654:Mesothelioma / Q000235:genetics*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000235:genetics*
D005819:Genetic Markers