title: Percutaneous transluminal coronary angioplasty for the treatment of variant angina.
abstract: Among 268 patients undergoing percutaneous transluminal coronary angioplasty between February 1980 and January 1983, a total of 21 patients had variant angina, documented before angioplasty in 14 and after angioplasty in 7. Before angioplasty, all 21 patients had rest angina and 17 also had effort angina; single vessel coronary artery disease with 60 to 95% stenosis was present in all patients and the left anterior descending coronary artery was involved in all but 3 patients. Coronary angioplasty was successful in 19 patients (90%). Eight of the 19 patients remained symptom-free without coronary restenosis after successful angioplasty; in the other 11 patients, angina reappeared within 4 months, usually in association with restenosis. Of the nine patients with coronary restenosis, six had repeat angioplasty (five successful procedures and one failure), two received medical therapy and one underwent coronary bypass surgery. Patients in whom calcium channel antagonists were discontinued immediately after angioplasty had an exceedingly high coronary restenosis rate (8 [80%] of 10 successful attempts), but when calcium antagonists were continued for an average of 6 +/- 4 months after angioplasty, the restenosis rate was low (3 [21%] of 14 successful attempts). After a mean (+/- SD) follow-up period of 33 +/- 13 months, 1 patient had died and the 20 others (95%) were symptom-free; among these 20, 15 patients (75%) had been taking no antianginal drugs for more than 1 year, 2 still received calcium channel antagonists and 3 had had coronary bypass surgery. Repeat coronary arteriography performed 14 +/- 7 months after angioplasty in the 17 patients without angioplasty-related infarction or surgery showed 50% or less coronary stenosis in 13 patients.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.forename: T
authors.initials: T
authors.lastname: Corcos
authors.forename: P R
authors.initials: PR
authors.lastname: David
authors.forename: M G
authors.initials: MG
authors.lastname: Bourassa
authors.forename: P G
authors.initials: PG
authors.lastname: Val
authors.forename: J
authors.initials: J
authors.lastname: Robert
authors.forename: L A
authors.initials: LA
authors.lastname: Mata
authors.forename: D D
authors.initials: DD
authors.lastname: Waters
mesh_terms: D000328:Adult; D000368:Aged; D000788:Angina Pectoris, Variant / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D000800:Angioplasty, Balloon; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003251:Constriction, Pathologic; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000209:etiology; D003331:Coronary Vessels / Q000473:pathology / Q000503:physiopathology; D004562:Electrocardiography; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence
chemical_list: D002121:Calcium Channel Blockers