Scrotal and abdominal skin necrosis complicating intravenous vasopressin therapy for bleeding esophageal varices.
Two patients with severe liver disease developed scrotal necrosis after intravenous vasopressin infusion for bleeding esophageal varices. One of these patients also developed anterior abdominal wall skin necrosis. Although ischemic complications secondary to vasopressin are probably not totally avoidable, attention to hypovolemia, concomitantly administered pressor drugs, patient position, and points of local pressure may decrease the likelihood of these previously unreported complications.
Gogel
H K
HK
Sherman
R W
RW
Becker
L E
LE
D000009:Abdominal Muscles / Q000473:pathology; D004932:Esophageal and Gastric Varices / Q000188:drug therapy*; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012611:Scrotum / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D014667:Vasopressins / Q000009:adverse effects*
D014667:Vasopressins