title: [Clinical and therapeutic aspects of maxillofacial lesions of Paget's disease].
abstract: Histopathology of mandibular swellings in two women aged 68 and 73 years respectively provided a diagnosis of Paget's disease. The complementary biological tests (phosphorus-calcium metabolism, alkaline phosphatase, hydroxyprolinuria) performed showed the increase in bone metabolism, while imaging techniques (conventional radiography, scintigraphy, CT scan) demonstrated numerous subclinical bony foci. Treatment of the facial deformity, if desirable esthetically or functionally necessary (alveolitis, osteitis) can only be surgical. If there is biological bone hypermetabolism, medical (diphosphonate, calcitonin) can be discussed with the rheumatologists. Evolutive risks are represented by rare sarcomatous transformations, osteomyelitis on Paget and monstrous deformities of the face, as in one of the patients reported who had refused all treatment over 37 years.
authors.affiliation: Service Stomatologie et Chirurgie maxillo-faciale, Hôpital Bellevue, Saint-Etienne.
authors.forename: P
authors.initials: P
authors.lastname: Seguin
authors.forename: J L
authors.initials: JL
authors.lastname: Béziat
authors.forename: R
authors.initials: R
authors.lastname: Achard
authors.forename: B
authors.initials: B
authors.lastname: Momège
mesh_terms: D000368:Aged; D005147:Facial Bones / Q000473:pathology*; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D010001:Osteitis Deformans / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery
vernacular_title: Aspects cliniques et thérapeutiques des atteintes maxillo-faciales de la maladie de Paget.