title: Thermal dose-response of magnetic-induction thermoradiotherapy.
abstract: Sixty-three patients with advanced cancer underwent greater than or equal to 5,000 cGy combined with Concentric Coil magnetic-induction localized hyperthermia. Tumor regression (CR + PR) was compared to thermal dose received, incorporating the premise that hyperthermia response is a function of time as well as temperature. A computer program was developed (after Sapareto and Dewey [2]) which stored minimum tumor temperatures recorded spatially and temporally during treatment and correlated response with T43 (equivalent minutes at 43 degrees C during the first treatment) and CT43 (cumulative T43, computed by multiplying T43 by the actual number of identical subsequent treatments received during the course of therapy). Those who responded--N = 46 (73%)--had significantly higher median thermal doses than those who did not respond. Comparison of T43 and CT43 thermal dose values between responders and nonresponders was significantly different at p values of 0.05 and 0.04, respectively. The data indicate that magnetic-induction hyperthermia and high-dose XRT was an effective treatment combination in advanced disease and that tumor response improved as thermal dose increased.
authors.affiliation: Jonsson Comprehensive Cancer Center, University of California, Los Angeles.
authors.forename: F K
authors.initials: FK
authors.lastname: Storm
authors.forename: R M
authors.initials: RM
authors.lastname: Elashoff
authors.forename: H W
authors.initials: HW
authors.lastname: Baker
authors.forename: E F
authors.initials: EF
authors.lastname: Scanlon
authors.forename: B
authors.initials: B
authors.lastname: Drury
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: D
authors.initials: D
authors.lastname: Roe
authors.forename: D L
authors.initials: DL
authors.lastname: Morton
mesh_terms: D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008280:Magnetics; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D011379:Prognosis; D011879:Radiotherapy Dosage