Tissue damage markers in experimental Chagas' disease.
Malondialdehydemia (MDA), measurements of heart and liver tissue damage (TDU), plasma activity of heart alpha-hydroxybutyrate dehydrogenase (LDH1) and liver lactate dehydrogenase (LDH5) were determined in non-infected mice and in mice infected with 10(5) T. cruzi, Y strain, bloodstream trypomastigotes. All the parameters measured were increased (P less than 0.01) in infected mice 8 days after intraperitoneal inoculation. The results indicate that plasma MDA levels can serve as a useful indicator of the systemic tissue injury found in Chagas' disease.
Palhares
P E
PE
Departamento de Protozoologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil.
Fontana Júnior
P
P
Schaffer
G M
GM
Marcondes
N S
NS
Vergara
M
M
D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D014355:Chagas Disease / Q000097:blood*; D006884:Hydroxybutyrate Dehydrogenase / Q000097:blood; D007527:Isoenzymes / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000201:enzymology*; D008297:Male; D008314:Malonates / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood*; D051379:Mice; D009206:Myocardium / Q000201:enzymology*
D007527:Isoenzymes; D008314:Malonates; D008315:Malondialdehyde; C035749:2-hydroxybutyrate dehydrogenase; D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase