[Expression of surface markers of lymphocytes and their relation to suppressor function in lymphogranulomatosis].
The patients with Hodgkins disease possessed an increased number of the T gamma-cells, a decreased number of T mu cells and higher endogenic suppressor activity as compared with healthy donors. Subpopulation of ferritin-carrying lymphocytes was found only in patients, whereas in donors these cells were not revealed at all. It was shown that ferritin receptors expressed only on T gamma-cells. For determination of the functional role of T-cell subpopulation before and after Con-A stimulation were studied. The suppression activity correlated with the T gamma-cell levels.
Tabagari
D Z
DZ
Chernovskaia
E M
EM
Kadagidze
Z G
ZG
D000328:Adult; D002462:Cell Membrane / Q000276:immunology; D002648:Child; D003208:Concanavalin A / Q000494:pharmacology; D003470:Culture Media; D005293:Ferritins / Q000097:blood* / Q000276:immunology; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology / Q000648:ultrastructure; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*
D003470:Culture Media; D003208:Concanavalin A; D005293:Ferritins
Ekspressiia poverkhnostnykh markerov limfotsitov i ikh sviaz' s supressornoĭ funktsieĭ pri limfogranulematoze.