title: Adrenal renin: a possible local hormonal regulator of aldosterone production.
abstract: The complete renin-angiotensin system is present in the adrenal cortex: prorenin, renin, angiotensinogen, angiotensin I and II, and converting enzyme. Most of the renin found is probably synthesized there since the renin concentration increases after nephrectomy, and the mRNA for renin is present. The renin-angiotensin system has the highest activity in the zona glomerulosa cells, the site of aldosterone formation. A low-sodium diet or a high-potassium diet, or nephrectomy markedly increases the adrenal renin concentration in the zona glomerulosa cells without any effect on the fasciculata-medullary cells. There is a close correlation between adrenal renin and aldosterone production. The adrenal renin angiotensin system may be a local regulator of aldosterone production.
authors.affiliation: Department of Internal Medicine and Pathology, Medical College of Ohio, Toledo 436991.
authors.forename: P J
authors.initials: PJ
authors.lastname: Mulrow
authors.forename: E
authors.initials: E
authors.lastname: Kusano
authors.forename: K
authors.initials: K
authors.lastname: Baba
authors.forename: D
authors.initials: D
authors.lastname: Shier
authors.forename: Y
authors.initials: Y
authors.lastname: Doi
authors.forename: R
authors.initials: R
authors.lastname: Franco-Saenz
authors.forename: G
authors.initials: G
authors.lastname: Stoner
authors.forename: J
authors.initials: J
authors.lastname: Rapp
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism / Q000502:physiology*; D000450:Aldosterone / Q000096:biosynthesis*; D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000502:physiology*
chemical_list: D000450:Aldosterone; D012083:Renin