Association between Km1 immunoglobulin allotype and pulmonary tuberculosis in Indonesians.
Allotypes were determined in 121 cases of smear-positive pulmonary tuberculosis and 33 healthy controls from Indonesia. It was found that the occurrence of Km1 was significantly lower in patients than in controls (p = 0.011), and that phenotypes lacking G1m (17) and G3m(21) as well as Km1 occurred much more frequently among patients than controls (p = 0.0025). Some evidence for an allotypic influence on the antibody response to mycobacterial antigens was found. A lack of G1m(17) or G3m(21) was associated with increased antibody levels in the IgG2 subclass in control subjects and a lack of Km1 with decreased antibody levels in the IgG4 subclass in patients.
Gibson
J
J
Cardiothoracic Institute, London, UK.
Grange
J
J
Beck
J S
JS
Kardjito
T
T
D000907:Antibodies, Bacterial / Q000032:analysis; D005260:Female; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000032:analysis*; D007129:Immunoglobulin Gm Allotypes / Q000032:analysis; D007214:Indonesia; D008297:Male; D009169:Mycobacterium tuberculosis / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
D000907:Antibodies, Bacterial; D007126:Immunoglobulin Allotypes; D007129:Immunoglobulin Gm Allotypes