title: Comparison of nalbuphine and fentanyl in combination with diazepam for outpatient oral surgery.
abstract: Nalbuphine and fentanyl were compared as analgesic components of intravenous conscious sedation with diazepam in a double-blind, prospective trial of 50 patients undergoing elective oral surgery. Subjects were evaluated for intensity of pain, pain relief, sedation, anxiety, recall, and vital signs at systematic observation points intraoperatively and postoperatively. At the conclusion of surgery, 88% who received nalbuphine and 87% treated with fentanyl indicated complete pain relief. One observed adverse reaction was attributed to the combination of fentanyl and the sedative component diazepam. No statistically significant differences were observed between nalbuphine and fentanyl treatments.
authors.affiliation: Division of Oral and Maxillofacial Surgery, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: E A
authors.initials: EA
authors.lastname: Dolan
authors.forename: W J
authors.initials: WJ
authors.lastname: Murray
authors.forename: A R
authors.initials: AR
authors.lastname: Immediata
authors.forename: N
authors.initials: N
authors.lastname: Gleason
mesh_terms: D000328:Adult; D000766:Anesthesia, Dental; D003975:Diazepam / Q000008:administration & dosage*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005069:Evaluation Studies as Topic; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009019:Morphinans / Q000008:administration & dosage*; D009266:Nalbuphine / Q000008:administration & dosage*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D011229:Preanesthetic Medication; D011446:Prospective Studies
chemical_list: D009019:Morphinans; D009266:Nalbuphine; D003975:Diazepam; D005283:Fentanyl