Cholinergic urticaria, passive transfer experiments from human to monkey.
Passive transfer experiments in cholinergic urticaria were carried out from 16 patients to a Macaca cymnologous monkey. Intravenous Evans blue dye was used to demonstrate vascular permeability. The animal was challenged after 24 h first by heating the serum-injected dorsal skin to 45 degrees C and secondly by superinjection of acetylcholine into serum-injected sites, and a control site. Local heat proved insufficient to evoke a response. Seven of 16 serum-injected sites showed positive reaction to acetylcholine, control injection of acetylcholine did not. These experiments suggest the presence of a serum factor in cholinergic urticaria which, with acetylcholine, causes increased vascular permeability.
Murphy
G M
GM
St John's Hospital for Diseases of the Skin, London, UK.
Greaves
M W
MW
Zollman
P E
PE
Winkelmann
R K
RK
D000109:Acetylcholine / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D000818:Animals; D002799:Cholinergic Fibers / Q000503:physiopathology*; D005260:Female; D000882:Haplorhini; D006801:Humans; D007116:Immunization, Passive; D007271:Injections, Intradermal; D007428:Intradermal Tests; D008297:Male; D008875:Middle Aged; D014581:Urticaria / Q000139:chemically induced*
D000109:Acetylcholine