Monotherapy or polychemotherapy in the treatment of Campylobacter pylori-related gastroduodenal disease.
Three pilot studies were performed to evaluate the efficacy of bismuth subsalicylate (BSS) and nitrofurantoin to eradicate Campylobacter pylori colonization in man. Nitrofurantoin 3 x 100 mg capsules for 10 days did not clear C. pylori in any of 13 patients, and neither did the combination of BSS and nitrofurantoin suspension (0/6 patients). Immediately after high dose BSS therapy 3 x 900 mg for 28 days, 8/17 patients (47%) had negative cultures and rapid urease tests. There was recrudescence in 5 out of 6 patients so far submitted to follow-up investigations, giving a best possible outcome estimate of 18% and a worst possible eradication rate of 6% in this study. Preliminary data indicate that triple therapy may be a more effective option, but doubts remain as to whether the puristic therapeutic goal of complete bacterial eradication can be safely and effectively achieved with presently available drugs.
Börsch
G
G
Department of Medicine, St. Josef-Hospital, Bochum, Federal Republic of Germany.
Mai
U
U
Müller
K M
KM
D000328:Adult; D001706:Biopsy; D001729:Bismuth; D002169:Campylobacter Infections / Q000150:complications* / Q000188:drug therapy; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D004415:Dyspepsia / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009582:Nitrofurantoin / Q000627:therapeutic use*; D009942:Organometallic Compounds / Q000627:therapeutic use*; D010865:Pilot Projects; D011706:Pyloric Antrum / Q000201:enzymology / Q000473:pathology; D012459:Salicylates / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D014510:Urease / Q000032:analysis
D009942:Organometallic Compounds; D012459:Salicylates; C015715:bismuth subsalicylate; D009582:Nitrofurantoin; D014510:Urease; D001729:Bismuth