A possible physiological function of pancreatic pro-colipase activation peptide in appetite regulation.
Pancreatic pro-colipase activation peptide, a pentapeptide with the sequence VPDPR was found to significantly suppress food intake of 20 h fasted Sprague-Dawley rats in a dose-dependent way. A rat treated with pro-colipase-enriched pellets for 26 days showed decreased daily food intake and retarded growth, which were restored during a following period of regular feeding. Genetically obese Zucker rats (fa/fa) were found to contain a reduced content of pancreatic pro-colipase (60% reduction), whereas the pancreatic lipase content was normal. A physiological function of pancreatic pro-colipase activation peptide as an endogenous satiety signal is suggested.
Erlanson-Albertsson
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Department of Medical and Physiological Chemistry, University of Lund, Sweden.
Larsson
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A
D000818:Animals; D001069:Appetite Regulation; D003089:Colipases / Q000378:metabolism*; D004792:Enzyme Precursors / Q000378:metabolism; D005260:Female; D009842:Oligopeptides / Q000502:physiology*; D010179:Pancreas / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014362:Trypsinogen / Q000378:metabolism
D003089:Colipases; D004792:Enzyme Precursors; D009842:Oligopeptides; D011498:Protein Precursors; D011506:Proteins; C037107:procolipase; D014362:Trypsinogen; C022443:proelastase; D010196:Pancreatic Elastase