title: Lack of effect of tenoxicam on glibornuride kinetics and response.
abstract: The pharmacokinetics of glibornuride (25 mg i.v.) and the accompanying insulin and glucose responses were characterized in eight human subjects in the presence and absence of steady-state tenoxicam (20 mg p.o./day for 2 weeks). Tenoxicam affected neither the pharmacokinetic parameters of glibornuride (systemic clearance, volume of distribution and biological half-life) nor the responses of plasma insulin and blood glucose to glibornuride. The single i.v. dose of glibornuride had no detectable effect on the kinetics of tenoxicam.
authors.forename: K
authors.initials: K
authors.lastname: Stoeckel
authors.forename: V
authors.initials: V
authors.lastname: Trueb
authors.forename: U C
authors.initials: UC
authors.lastname: Dubach
authors.forename: R C
authors.initials: RC
authors.lastname: Heintz
authors.forename: V
authors.initials: V
authors.lastname: Ascalone
authors.forename: I
authors.initials: I
authors.lastname: Forgo
authors.forename: U
authors.initials: U
authors.lastname: Hennes
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007700:Kinetics; D008297:Male; D010894:Piroxicam / Q000031:analogs & derivatives*; D013453:Sulfonylurea Compounds / Q000097:blood / Q000378:metabolism*; D013843:Thiazines / Q000378:metabolism*; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D001786:Blood Glucose; D007328:Insulin; D013453:Sulfonylurea Compounds; D013843:Thiazines; D010894:Piroxicam; C032801:tenoxicam