Complex cytogenetic changes in Ph-negative chronic myelogenous leukemia.
A Ph-negative chronic myelogenous leukemia (CML) with t(3;7)(q21;q32), t(4;9)(q21;q34), and del(8)(q22) is reported. This case is rather unusual for Ph-negative CML in being associated with complex chromosome changes. The patient was diagnosed as in the accelerated phase of CML. It will be important to study this malignant disorder in detail cytogenetically and molecularly in order to ascertain its nature and place among the myeloproliferative disorders.
Wang
T Y
TY
Department of Genetics and Endocrinology, Roswell Park Memorial Institute, Buffalo, New York.
Raza
A
A
Fan
Y S
YS
Sait
S N
SN
Kirschner
J
J
Sandberg
A A
AA
D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic