Acute kindling: interstimulation interval effects and spontaneous interictal or ictal epileptiform discharges.
With regard to "acute kindling" that signifies progressive changes in various epileptiform discharges produced with repeated electrical stimulations in a brief time span in acute experiments, the interstimulation interval effect was examined. Kindling developments produced respectively with 3 and 30-minute interval stimulations to the visual cortex of rabbits were compared with each other. Eventually, in kindling with a longer interstimulation interval, after-discharges induced in every trial of stimulation were often lengthened in duration more prominently than those with the shorter interstimulation interval and, furthermore, occasional slight relapses in the afterdischarge duration occurred more infrequently in the former than in the latter. These results suggest that the interstimulation interval plays an important role in the development of acute kindling, presumably in relation to postictal inhibition. In addition, spontaneous interictal or ictal epileptiform discharges occasionally arising during the 3-minute interstimulation intervals were reported. These spontaneous discharges may suggest a high epileptogenicity in acute kindling.
Jibiki
I
I
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Kubota
T
T
Yamaguchi
N
N
D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology*; D004558:Electric Stimulation; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000503:physiopathology*; D005071:Evoked Potentials; D007696:Kindling, Neurologic; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology; D011817:Rabbits; D014793:Visual Cortex / Q000503:physiopathology