Inhibition of conjugal transfer by new quinolinic compounds.
We found that nalidixic acid is a good inhibitor of conjugal transfer of R-plasmids and that related compounds show the same properties. We investigated recently synthetized quinolinic molecules. The inhibition was not due to bacterial activity of the compounds against donors, recipients or R transconjugants; in fact, the drug concentrations were twice or four times lower than the M.I.C. values. The new molecules showed a marked inhibitory effect in various R-mating experiments.
Oliva
B
B
Selan
L
L
Ravagnan
G
G
Renzini
G
G
D042462:4-Quinolones; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D003227:Conjugation, Genetic / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D009268:Nalidixic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D009643:Norfloxacin; D011804:Quinolines / Q000494:pharmacology*; D015363:Quinolones
D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D011804:Quinolines; D015363:Quinolones; D009268:Nalidixic Acid; C021083:rosoxacin; D002939:Ciprofloxacin; D009643:Norfloxacin