Effects of indomethacin and etodolac on coronary blood flow and other cardiovascular variables in propranolol-treated dogs.
Indomethacin has been reported to induce coronary vasoconstriction in patients treated with beta-adrenoceptor blockers and nitrates. In the present investigation, the possibility that coronary blood flow was affected by a direct or indirect interaction between nonsteroidal anti-inflammatory drugs and propranolol was studied in the anesthetized dog. During beta-adrenoceptor blockade by propranolol, both indomethacin and etodolac failed to decrease coronary blood flow. When administered alone at doses sufficient to inhibit prostaglandin synthesis, indomethacin and etodolac did not reduce the coronary blood flow. It was concluded that there was no interaction between propranolol and the nonsteroidal anti-inflammatory drugs used. The results also suggested that the role of prostaglandins in the regulation of the coronary circulation remains an open question.
Beaulieu
G
G
D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D017308:Etodolac; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D000085:Acetates; D000893:Anti-Inflammatory Agents; D017308:Etodolac; D011433:Propranolol; D007213:Indomethacin