Effect of Nocardia rubra cell wall skeleton and/or cyclophosphamide on leukemogenesis induced by N-ethyl-N-nitrosourea in Donryu rats.
The effect of Nocardia rubra cell wall skeleton (N-CWS) and/or cyclophosphamide (CP) on chemical carcinogenesis was examined in female Donryu rats exposed to N-ethyl-N-nitrosourea (ENU) in the drinking water for 6 weeks. Five administrations of N-CWS following ENU treatment caused a slight prolongation of the average survival of rats but did not reduce the incidence of leukemia. CP given on two occasions after ENU treatment caused a moderate prolongation of average survival period and a moderate reduction of the incidence of leukemia, but significant differences from ENU-treated control group values were not observed after statistical analysis. Combined treatment with N-CWS and CP after ENU treatment caused prolongation of the average survival period of rats and a statistically significant reduction in the incidence of leukemia. The present experiment indicates that combined treatment with N-CWS and CP effectively reduces induction of leukemia by ENU in rats, although other types of tumors were not affected.
Ogiu
T
T
Furuta
K
K
Matsuoka
C
C
Maekawa
A
A
Azuma
I
I
D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology; D017358:Cell Wall Skeleton; D003520:Cyclophosphamide / Q000494:pharmacology*; D004067:Digestive System Neoplasms / Q000139:chemically induced; D005038:Ethylnitrosourea; D005260:Female; D007942:Leukemia, Experimental / Q000139:chemically induced* / Q000517:prevention & control; D009088:Mucoproteins / Q000494:pharmacology*; D009171:Mycolic Acids / Q000494:pharmacology*; D009607:Nitrosourea Compounds; D009615:Nocardia; D051381:Rats; D011919:Rats, Inbred Strains
D001500:BCG Vaccine; D017358:Cell Wall Skeleton; D009088:Mucoproteins; D009171:Mycolic Acids; D009607:Nitrosourea Compounds; D003520:Cyclophosphamide; D005038:Ethylnitrosourea