[The clinical usefulness of the measurement of serum sialyl SSEA-1 antigen levels in patients with gynecologic diseases: as respects the comparative effectiveness of sialyl SSEA-1 and CA125].
Increased concentrations of serum Sialyl SSEA-1 antigen, which belongs to type 2 chain carbohydrate antigens and is defined by a new monoclonal antibody FH-6, were observed in 47.2% of patients with ovarian cancer. The Sialyl SSEA-1 test may not be of use in detecting ovarian cancer in the early stages, because the positivity gradually increased with the clinical stages. However, the measurement of the Sialyl SSEA-1 concentrations was a useful tool to use in making a prognosis. The sialyl SSEA-1 and CA125 combination test was not useful in increasing sensitivity because of overlapping of the positivity. Increases in both serum Sialyl SSEA-1 and CA125 indicated the presence of malignancies associated with ovarian tumors in pregnant women. On the other hand, the Sialyl SSEA-1 test showed significantly low false positivity for non-neoplastic diseases except endometriosis.
Kobayashi
H
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Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine.
D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor / Q000097:blood*; D004715:Endometriosis / Q000175:diagnosis; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis*
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor