Immediate functional recovery and avoidance of reperfusion injury with surgical revascularization of short-term coronary occlusion.
Functional recovery with surgical revascularization of acutely ischemic myocardium has not been compared with its nonsurgical counterpart in experimental preparations of coronary occlusion. This study compares the functional and metabolic recovery of ischemic (1 hr coronary occlusion) segments revascularized either by restoration of coronary patency (simulating nonsurgical recanalization, e.g., angioplasty) or by surgical revascularization with multidose hypothermic potassium blood cardioplegic solution. Twenty-two anesthetized open-chest dogs were instrumented with Millar micromanometer-tip catheters to measure left ventricular and aortic pressures. Piezoelectric ultrasonic dimension gauges were implanted in the subendocardium supplied by the left anterior descending coronary artery to measure segmental contractile function. In five dogs, only biopsy samples were obtained for control measurements of ATP, creatine phosphate, and tissue water content. In the remaining 17 dogs, the left anterior descending artery and collaterals were ligated for 1 hr. The ligatures were removed in eight dogs and coronary perfusion continued for 2 hr, simulating nonsurgical reperfusion. The remaining nine dogs were placed on cardiopulmonary bypass and the hearts were arrested for 1 hr with multidose (every 20 min) blood cardioplegic solution enhanced with glutamate and aspartate, simulating surgical revascularization (coronary artery bypass grafting). The coronary ligatures were not released until the second cardioplegic infusion, simulating graft placement. One hour of coronary occlusion placed 39.4 +/- 2.5% of the left ventricle at risk, and converted active systolic shortening to persistent paradoxical bulging (25.2 +/- 2.2% to -5.8 +/- 1.2% systolic shortening).(ABSTRACT TRUNCATED AT 250 WORDS)
Vinten-Johansen
J
J
Edgerton
T A
TA
Howe
H R
HR
Gayheart
P A
PA
Mills
S A
SA
Howard
G
G
Cordell
A R
AR
D000255:Adenosine Triphosphate / Q000032:analysis; D000800:Angioplasty, Balloon; D000818:Animals; D009202:Cardiomyopathies / Q000473:pathology; D003327:Coronary Disease / Q000628:therapy*; D003331:Coronary Vessels / Q000293:injuries*; D003597:Cytosine Nucleotides / Q000032:analysis; D004285:Dogs; D006324:Heart Arrest, Induced; D009204:Myocardial Revascularization / Q000009:adverse effects*; D009206:Myocardium / Q000032:analysis; D009336:Necrosis / Q000473:pathology; D010477:Perfusion
D003597:Cytosine Nucleotides; D000255:Adenosine Triphosphate