In vitro interaction between the penem FCE 22101 and ceftazidime.
FCE 22101, a penem antimicrobial agent, was found to resist hydrolysis by bacterial beta-lactamases and to have a strong affinity for Type Ia enzymes. Like imipenem, FCE 22101 was shown to be capable of inducing resistance to a wide range of beta-lactam antibiotics. FCE 22101 antagonized the in vitro activity of ceftazidime against enteric bacilli that commonly produce inducible enzymes. This penem should not be combined with other beta-lactams for chemotherapeutic purposes.
Barry
A L
AL
Clinical Microbiology Institute, Tualatin, Oregon 97062.
Jones
R N
RN
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems; D002442:Ceftazidime / Q000494:pharmacology*; D004347:Drug Interactions; D004790:Enzyme Induction; D006868:Hydrolysis; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D002442:Ceftazidime; C040033:ritipenem; D001618:beta-Lactamases