Streptozotocin diabetes in juvenile pigs. Evaluation of an experimental model.
Spontaneous diabetes in the domestic pig, an animal suitable for metabolic and endocrine studies and for experimental surgery, is extremely rare. In this study we have compared the diabetogenic response of various doses of streptozotocin in comparison to surgically induced diabetes. Streptozotocin in a low dose, 35 mg/kg body weight did not influence glucose metabolism while an intermediate dose, 85 mg/kg, resulted in a transient diabetic reaction. Streptozotocin, 100-150 mg/kg body weight, caused a complete and permanent diabetes. Animals made diabetic by means of pancreatectomy did not survive more than 10 days due to their poor general condition and diabetes. Streptozotocin induced diabetic animals survived with insulin treatment up to seven months. The results show that juvenile pigs made diabetic with 100-150 mg/kg body weight of streptozotocin may be useful in experimental work on glucose-, insulin- and C-peptide-metabolism in a large animal. Therefore it is potentially useful in pancreatic transplantation research.
Gäbel
H
H
Bitter-Suermann
H
H
Henriksson
C
C
Säve-Söderbergh
J
J
Lundholm
K
K
Brynger
H
H
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000209:etiology* / Q000503:physiopathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D007515:Islets of Langerhans / Q000187:drug effects; D008297:Male; D013311:Streptozocin / Q000633:toxicity
D013311:Streptozocin