Epithelial cutaneous lesions induced in Dunkin-Hartley albino guinea-pigs by means of 7,12-dimethyl-benzanthracene.
We carried out a clinicopathological study of epithelial cutaneous lesions induced in Dunkin-Hartley albino guinea-pigs by means of the topical application of 7,12-dimethyl-benzanracene. By the end of the study we had observed 4451 lesions. Most frequently observed were epithelial hyperplasia and dysplasia (2544 lesions). Neoplasias consisted of 244 carcinomas in situ, and 88 squamous carcinomas. Basal-cell epitheliomas were few. Epidermal cysts were a frequent finding.
Gómez
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S
Department of Pathology, Faculty of Medicine, University of Murcia, Spain.
Vicente
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D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002278:Carcinoma in Situ / Q000139:chemically induced; D002280:Basal Cell Carcinoma / Q000139:chemically induced; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D004195:Disease Models, Animal; D004814:Epidermal Cyst / Q000139:chemically induced; D004848:Epithelium / Q000473:pathology; D006168:Guinea Pigs; D006965:Hyperplasia / Q000139:chemically induced; D008297:Male; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology
D015127:9,10-Dimethyl-1,2-benzanthracene