title: Efficient computations in multilocus linkage analysis.
abstract: This paper describes efficient methods for likelihood calculations and maximum-likelihood estimation in multilocus linkage analysis of reference families and general disease pedigrees, and it documents their performance as implemented in the LINKAGE programs. This information should be of considerable value in determining computing needs for linkage investigations, and in evaluating the merits of alternative algorithms.
authors.affiliation: Howard Hughes Medical Institute, University of Utah, Salt Lake City 84132.
authors.forename: G M
authors.initials: GM
authors.lastname: Lathrop
authors.forename: J M
authors.initials: JM
authors.lastname: Lalouel
mesh_terms: D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D011336:Probability; D011995:Recombination, Genetic
chemical_list: D005819:Genetic Markers