Dissolution of antisecretory and cytoprotective action of PGE2 in rats.
Oral administration of 60% ethanol in 150 mM HCl (HCl.ethanol) to rats produced gastric mucosal lesions within 1 hr. PGE2 given s.c. at 0.1 to 3 mg/kg 0.5 hr before HCl.ethanol significantly prevented the lesion formation. The protection afforded with 3 mg/kg of PGE2 persisted for 6 or 12 hr after administration. PGE2 given s.c. at 3 mg/kg significantly inhibited gastric secretion in pylorus-ligated and intact rats, but the action disappeared 6 hr later.
Wang
J Y
JY
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan.
Takeuchi
K
K
Okabe
S
S
D000818:Animals; D000897:Anti-Ulcer Agents; D015232:Dinoprostone; D000431:Ethanol / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology*; D011708:Pylorus / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D000897:Anti-Ulcer Agents; D011458:Prostaglandins E; D000431:Ethanol; D015232:Dinoprostone