title: Enhanced pressor sensitivity to oral tyramine challenge following high dose selegiline treatment.
abstract: Blood pressure and heart rate responses to oral tyramine have been measured in healthy volunteers before and after administration of the selective monoamine oxidase B inhibitor selegiline at high dosage (30 mg/day). Treatment brought about a 2 to 4-fold increase in tyramine sensitivity and a concomitant small but significant reduction in plasma 4-hydroxy-3-methoxyphenylglycol concentration, pointing to the emergence of some degree of monoamine oxidase A inhibition. It is suggested that patients treated with selegiline 30 mg/day or more should be placed on a tyramine-free diet.
authors.affiliation: Bernhard Baron Memorial Research Laboratories, Queen Charlotte's Maternity Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Prasad
authors.forename: V
authors.initials: V
authors.lastname: Glover
authors.forename: B L
authors.initials: BL
authors.lastname: Goodwin
authors.forename: M
authors.initials: M
authors.lastname: Sandler
authors.forename: M
authors.initials: M
authors.lastname: Signy
authors.forename: S E
authors.initials: SE
authors.lastname: Smith
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000201:enzymology; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D010627:Phenethylamines / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects; D012642:Selegiline / Q000494:pharmacology*; D014439:Tyramine / Q000494:pharmacology*
chemical_list: D010627:Phenethylamines; D012642:Selegiline; D008734:Methoxyhydroxyphenylglycol; D014439:Tyramine