Ataxia telangiectasia and acinic cell carcinoma of the parotid gland.
An increased incidence of malignancies occurs in ataxia telangiectasia. These are most frequently hematopoietic in children and epithelial in adults. Both cellular immunodeficiency and chromosome damage have been implicated in their etiology. There has been only one report of a salivary malignancy, a parotid mucoepidermoid carcinoma. We describe a second salivary malignancy, a metastasizing acinic cell carcinoma of the parotid gland, that developed in a 33-yr-old woman with ataxia telangiectasia. The marked chromosomal abnormalities that were present may have been involved in the pathogenesis of her tumor.
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Department of Surgery, Rhode Island Hospital, Providence 02902.
Coleman
G
G
Ree
J H
JH
Abuelo
D N
DN
Crowley
J P
JP
D000328:Adult; D001260:Ataxia Telangiectasia / Q000150:complications* / Q000235:genetics / Q000276:immunology; D002277:Carcinoma / Q000209:etiology*; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D010307:Parotid Neoplasms / Q000209:etiology*