Effect of ciprofloxacin on subcutaneous abscesses induced with Staphylococcus epidermidis and a foreign body implant in the mouse.
Subcutaneous abscesses were induced in mice with Staphylococcus epidermidis strain G19-85 and a foreign body implant. The MIC of ciprofloxacin for this strain was 0.25 microgram/ml. The ciprofloxacin dosage, 120 mg/kg/day, was divided into three injections, administered to the mice subcutaneously at 8 h intervals. Serum concentration kinetics in normal mice (n = 50) were determined. The peak serum level of ciprofloxacin was 3.18 micrograms/ml at the 15 min sampling time; the trough level was 0.53 micrograms/ml at 8 h. Abscesses were found in 96% (n = 49) of the untreated, infected control mice. Three modes of treatment with ciprofloxacin were tested: (1) four prophylactic injections of ciprofloxacin prior to infection reduced abscess formation to 64% (p less than or equal to 0.0002, n = 50). (2) Eleven therapeutic injections, initiated 4 days after infection, reduced abscess formation to 86% (p less than or equal to 0.17, n = 49). (3) One prophylactic injection prior to surgery and five therapeutic injections after infection reduced abscess formation to 43% (p less than or equal to 0.0001, n = 49). Culture results correlated with the abscess formation rates.
Mayberry-Carson
K J
KJ
Department of Microbiology, Quillen-Dishner College of Medicine, East Tennessee State University, Johnson City 37614-0002.
Tober-Meyer
B
B
Gill
L R
LR
Lambe
D W
DW
Mayberry
W R
WR
D000038:Abscess / Q000188:drug therapy* / Q000517:prevention & control; D000818:Animals; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005547:Foreign Bodies; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D013207:Staphylococcal Skin Infections / Q000188:drug therapy* / Q000517:prevention & control; D013212:Staphylococcus epidermidis
D002939:Ciprofloxacin