Effects of islet transplantation on the recipient endocrine pancreas.
Streptozotocin diabetic rats were treated with a syngeneic splenic islet transplantation. 17 weeks later the insulin content and the beta-cell mass were investigated in the host pancreas and compared with untreated diabetic or normal rats. The diabetic animals retained 8% of beta-cells, and 2.5% of insulin content as compared with normal controls. Successfully grafted rats are characterized by an increase of beta-cell volume (420%) and insulin content (2350%) in comparison to untreated diabetic rats. However, a detailed individual analysis revealed a marked differentiation between the animals investigated, the cause of which remains to be clarified.
Hahn
H J
HJ
Lucke
S
S
Ziegler
B
B
Besch
W
W
Kauert
C
C
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006943:Hyperglycemia / Q000473:pathology / Q000503:physiopathology*; D007515:Islets of Langerhans / Q000166:cytology; D016381:Islets of Langerhans Transplantation; D051381:Rats; D013311:Streptozocin
D013311:Streptozocin