Electrocardiogram of rabbits experimentally intoxicated with carbaryl.
Experiments were carried out on 24 rabbits intoxicated intragastrically with carbaryl in single doses of 500, 750, 1000 and 1250 mg/kg. Electrocardiograms (ECGs) were performed in 3 limb leads before and 1, 2, 4, 6h and 1, 2, 4, 6, 14d after intoxication and in a final stage of lethal intoxications--in a continuous manner. It has been found that, depending on the intensification of disease, ECG changes were characterized by the decreased heart rate with stimulations coming from the left ventricle, premature supraventricular stimulations, increased T wave amplitude and its reversion. These changes, except two lethal cases (1250 mg/kg), were compensated but the compensatory heart abilities decreased with increasing carbaryl doses.
Kossakowski
S
S
Research Centre of Veterinary Service, Puławy.
D000818:Animals; D001919:Bradycardia / Q000139:chemically induced; D012721:Carbaryl / Q000008:administration & dosage / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects*; D011817:Rabbits; D013617:Tachycardia, Supraventricular / Q000139:chemically induced
D012721:Carbaryl