Interaction of iron-adriamycin complexes with ceruloplasmin and apotransferrin.
1. The present kinetic study suggests that the Fe(II)-adriamycin complex acts as substrate for ceruloplasmin, which oxidizes the complex to the ferric form (Km = 21.7 microM). 2. Apotransferrin readily removes iron from Fe(III)-adriamycin. 3. However, adriamycin, at low concentration, is able to take up some iron from a 20% iron-saturated transferrin solution; a reaction which may take place in vivo.
Løvstad
R A
RA
Institute of Medical Biochemistry, University of Oslo Sognsvannsveien, Norway.
D001059:Apoproteins / Q000378:metabolism*; D002570:Ceruloplasmin / Q000378:metabolism*; D004317:Doxorubicin / Q000378:metabolism*; D005296:Ferrous Compounds / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism*
D001059:Apoproteins; D005296:Ferrous Compounds; D014168:Transferrin; C028284:apotransferrin; D004317:Doxorubicin; D002570:Ceruloplasmin