title: Immune responses to Mycoplasma bovis vaccination and experimental infection in the bovine mammary gland.
abstract: This study characterized the immune responses in four vaccinated and four control cows in response to vaccination and experimental intramammary inoculation with Mycoplasma bovis. Specific antibody responses occurred in serum and milk in response to vaccination and experimental infection. Lymphocytes from peripheral blood, but not from the mammary gland of vaccinated cows had increased responsiveness to mitogens. No lymphocytes tested were responsive to M. bovis antigen. Both vaccination and experimental infection resulted in skin test reactivity. These results imply that vaccination results in immune responses which may alter the course of experimental M. bovis mastitis, but may contribute to cellular inflammation.
authors.affiliation: Department of Clinical Pathology, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: J T
authors.initials: JT
authors.lastname: Boothby
authors.forename: C E
authors.initials: CE
authors.lastname: Schore
authors.forename: D E
authors.initials: DE
authors.lastname: Jasper
authors.forename: B I
authors.initials: BI
authors.lastname: Osburn
authors.forename: C B
authors.initials: CB
authors.lastname: Thomas
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D001428:Bacterial Vaccines / Q000276:immunology*; D002417:Cattle; D005260:Female; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008321:Mammary Glands, Animal / Q000276:immunology; D008414:Mastitis, Bovine / Q000276:immunology*; D008892:Milk / Q000276:immunology; D009174:Mycoplasma / Q000276:immunology*; D009175:Mycoplasma Infections / Q000276:immunology / Q000662:veterinary*; D012882:Skin Tests / Q000662:veterinary; D014611:Vaccination / Q000662:veterinary
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines