Behçet's disease: clinical and immunological response to immunosuppressive therapy. A case report.
A patient with Behçet's disease had recurrent bilateral uveitis with retinal exudates and visual deterioration while under intermittent corticosteroid treatment. His peripheral blood lymphocytes showed the following abnormalities: low percentage of T cells; low T cell suppressor activity; high spontaneous B cell proliferation; and high response to phytohemagglutinin. Prostaglandin-producing adherent cells were found to have suppressive activity. Chlorambucil induced a clinical and immunological remission.
Rimon
D
D
Lahat
N
N
Nir
E
E
Cohen
L
L
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D001528:Behcet Syndrome / Q000188:drug therapy / Q000276:immunology*; D002699:Chlorambucil / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D013601:T-Lymphocytes; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D007166:Immunosuppressive Agents; D002699:Chlorambucil