Survival in complicated diphenhydramine overdose.
This report describes the first case of an adult to survive all the major complications of diphenhydramine hydrochloride overdose, including hyperpyrexia, status epilepticus, coma, and cardiac arrhythmias. Physostigmine appeared to be of benefit in reversing these abnormalities in combination with other therapies.
Rinder
C S
CS
Department of Anesthesiology, Maine Medical Center, Portland 04102.
D'Amato
S L
SL
Rinder
H M
HM
Cox
P M
PM
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D003128:Coma / Q000139:chemically induced / Q000188:drug therapy; D004155:Diphenhydramine / Q000506:poisoning*; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D004366:Nonprescription Drugs / Q000506:poisoning*; D010830:Physostigmine / Q000627:therapeutic use; D013226:Status Epilepticus / Q000139:chemically induced / Q000188:drug therapy
D004366:Nonprescription Drugs; D004155:Diphenhydramine; D010830:Physostigmine