Pharmacokinetics of a new oral antibacterial agent, ofloxacin, in dentistry and oral surgery.
The new oral antibacterial agent, ofloxacin, was administered for prophylactic purposes to a group of 12 patients with dental and oral inflammatory processes requiring oral surgery. Drug concentrations in serum, saliva and gingival mucosa were assayed at different times after administration of the drug. Good serum, salivary and gingival mucosal tissue concentrations were achieved.
Bedeschi
G
G
Department of Stomatology and Maxillofacial Surgery, Clinical Hospital of Verona, Italy.
Beltrame
M
M
Baldin
C
C
Confente
G
G
Guerra
L
L
Fostini
R
R
D000328:Adult; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D005260:Female; D005881:Gingiva / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D008297:Male; D009055:Mouth / Q000601:surgery; D009061:Mouth Mucosa / Q000378:metabolism; D015242:Ofloxacin; D010078:Oxazines / Q000493:pharmacokinetics*; D012463:Saliva / Q000378:metabolism
D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin