Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase.
Biller
S A
SA
Squibb Institute for Medical Research, Princeton, New Jersey 08543-4000.
Forster
C
C
Gordon
E M
EM
Harrity
T
T
Scott
W A
WA
Ciosek
C P
CP
D000818:Animals; D004164:Diphosphonates / Q000494:pharmacology*; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008862:Microsomes, Liver / Q000201:enzymology; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D011106:Polyisoprenyl Phosphates / Q000494:pharmacology*; D051381:Rats; D012717:Sesquiterpenes; D013729:Terpenes / Q000494:pharmacology*
D004164:Diphosphonates; D009943:Organophosphorus Compounds; D011106:Polyisoprenyl Phosphates; D012717:Sesquiterpenes; D013729:Terpenes; C004808:farnesyl pyrophosphate; D010088:Oxidoreductases; D013186:Farnesyl-Diphosphate Farnesyltransferase