Expression of the c-fos proto-oncogene in bone, cartilage and tooth forming tissues during mouse development.
The c-fos proto-oncogene is the cellular homologue of v-fos identified as the bone transforming gene of the FBJ and the FBR murine osteosarcoma viruses. We show here, using a sensitive in situ hybridization method, that the c-fos proto-oncogene is expressed in the cartilage, bone and tooth forming tissues during mouse development. This result suggests that the tumors observed after infection by the FBJ viral complex and c-fos overexpression in transgenic mice occur in those tissues in which c-fos is expressed during development.
Caubet
J F
JF
INSERM U 139, C.H.U. Henri Mondor, Creteil, France.
Bernaudin
J F
JF
D000818:Animals; D001842:Bone and Bones / Q000032:analysis / Q000196:embryology*; D002356:Cartilage / Q000032:analysis / Q000166:cytology / Q000196:embryology*; D005786:Gene Expression Regulation; D051379:Mice; D008822:Mice, Transgenic; D009693:Nucleic Acid Hybridization; D009804:Odontoblasts / Q000032:analysis; D010006:Osteoblasts / Q000032:analysis; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger / Q000032:analysis; D014070:Tooth / Q000032:analysis / Q000196:embryology*
D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger