title: Nonamyloidotic monoclonal immunoglobulin deposits lack amyloid P component.
abstract: Deposits in tissues from 13 patients with amyloid, 8 with monoclonal light chain or light and heavy chain deposition disease, and 2 with both amyloid and nonamyloidotic light chain deposits of the same isotype were examined in parallel for the presence of amyloid P component by immunofluorescence and/or immunoperoxidase methods. Amyloid P component was detected in the amyloid but not the nonamyloid deposits, even in the 2 individuals in whom both types of deposits were present, indicating a specific relationship between the amyloid P component and the amyloid fibrils.
authors.affiliation: Department of Pathology, New York University School of Medicine, New York.
authors.forename: G
authors.initials: G
authors.lastname: Gallo
authors.forename: M
authors.initials: M
authors.lastname: Picken
authors.forename: B
authors.initials: B
authors.lastname: Frangione
authors.forename: J
authors.initials: J
authors.lastname: Buxbaum
mesh_terms: D000686:Amyloidosis / Q000276:immunology*; D003106:Colon / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006362:Heavy Chain Disease / Q000276:immunology*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007124:Immunoenzyme Techniques; D007137:Immunoglobulin alpha-Chains / Q000032:analysis; D007142:Immunoglobulin gamma-Chains / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D007668:Kidney / Q000276:immunology; D000683:Serum Amyloid P-Component / Q000032:analysis*
chemical_list: D007137:Immunoglobulin alpha-Chains; D007142:Immunoglobulin gamma-Chains; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D000683:Serum Amyloid P-Component