title: Clinical and laboratory assessments of camphorated monochlorophenol in endodontic therapy.
abstract: The purpose of this study was to evaluate the effect of camphorated monochlorophenol (CMCP) on bacterial status of root canals of nonvital teeth during treatments. The presence of bacteria in 15 single-rooted teeth with periapical lesions was studied throughout a whole period of treatment. Patients were randomly divided into three groups. In group 1, a control group, the intracanal medication was omitted. The teeth were enlarged under aseptic conditions in combination with the use of 3% H2O2 and 5.25% NaOCl as irrigants. In group 2, after chemomechanical preparation, the root canals were dressed with 2 microliter of 40% CMCP. The medicament was replaced on days 3 and 7. In group 3, root canals were treated in a manner similar to those in group 2, except that the medicament was renewed on days 1 and 7. The loss of CMCP was determined in groups 2 and 3. The results showed that chemomechanical preparation could reduce bacteria in root canals to an uncultivable number. Approximately 62.5% of the original concentration of CMCP was lost after placement in root canals for 1 day. Intracanal dressing with CMCP between appointments induced a rapid decrease in number of bacteria in root canals within the first 1 to 3 days. However, compared to chemomechanical preparation, the antimicrobial effect of CMCP was not clinically impressive because negative cultures also could be observed despite the absence of intracanal medications.
authors.affiliation: Department of Physiology and Biochemistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Koontongkaew
authors.forename: R
authors.initials: R
authors.lastname: Silapichit
authors.forename: B
authors.initials: B
authors.lastname: Thaweboon
mesh_terms: D000891:Anti-Infective Agents, Local / Q000032:analysis / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D002164:Camphor / Q000032:analysis / Q000627:therapeutic use*; D002733:Chlorophenols / Q000032:analysis / Q000627:therapeutic use*; D003786:Dental Pulp Cavity / Q000382:microbiology*; D004202:Disinfectants / Q000032:analysis / Q000627:therapeutic use*; D004338:Drug Combinations / Q000032:analysis / Q000627:therapeutic use; D006801:Humans; D010209:Paper; D012388:Root Canal Irrigants / Q000032:analysis / Q000627:therapeutic use*; D012390:Root Canal Therapy
chemical_list: D000891:Anti-Infective Agents, Local; D002733:Chlorophenols; D004202:Disinfectants; D004338:Drug Combinations; D012388:Root Canal Irrigants; D002164:Camphor; C029804:camphorated parachlorophenol