Regulation of IgM expression by adjuvant activated splenic suppressor T cells.
Adjuvant-activated Lyt-2 positive suppressor T cells (Ts) are able to inhibit the expression of IgM plaque-forming cells (PFC) during a primary in vitro response to sheep red blood cells. Under the same experimental conditions these suppressor T cells do not affect a secondary IgM PFC response against SRBC. Activated Ts cells were also found to suppress the spontaneous IgM secretion of cultured B cells as well as the IgM production of B cells stimulated by lipopolysaccharide or by supernatant from a T-helper-cell clone.
Lowy
I
I
Leclercq
L
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Theze
J
J
D000818:Animals; D000950:Antigens, Ly / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000950:Antigens, Ly; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M