title: Hyponatremia and renal sodium wasting in patients receiving cisplatinum.
abstract: Three children with malignant solid tumors developed hyponatremia with renal sodium wasting associated with other signs of tubular dysfunction, such as hypokalemia or hypomagnesemia, a few days after cis-diammine dichloroplatinum (CDDP) administration. The normalization of serum electrolyte disturbances was obtained with increased parenteral intakes in fluids and electrolytes, and renal sodium wasting stopped by itself a few days later.
authors.affiliation: Institut Gustave Roussy, Villejuif, France.
authors.forename: G
authors.initials: G
authors.lastname: Vassal
authors.forename: H
authors.initials: H
authors.lastname: Rubie
authors.forename: C
authors.initials: C
authors.lastname: Kalifa
authors.forename: O
authors.initials: O
authors.lastname: Hartmann
authors.forename: J
authors.initials: J
authors.lastname: Lemerle
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000150:complications / Q000188:drug therapy; D002648:Child; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced* / Q000175:diagnosis; D007085:Ilium; D007177:Inappropriate ADH Syndrome / Q000175:diagnosis; D007223:Infant; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009447:Neuroblastoma / Q000150:complications / Q000188:drug therapy; D012512:Sarcoma, Ewing / Q000150:complications / Q000188:drug therapy; D012964:Sodium / Q000378:metabolism; D013899:Thoracic Neoplasms / Q000150:complications / Q000188:drug therapy
chemical_list: D012964:Sodium; D002945:Cisplatin