title: Spectinomycin modification. III. Spectinomycin analogs with C-3'-branched chain sugars.
abstract: A variety of C-3'-branched chain analogs of spectinomycin has been synthesized via the intermediacy of spectinomycin derived diazoketones. In vitro antibacterial assay of these compounds has underscored the importance of hydrogen bonding functional groups in this region of the molecule. The most potent of these analogs had activity greater than or equal to the parent.
authors.forename: R C
authors.initials: RC
authors.lastname: Thomas
authors.forename: E L
authors.initials: EL
authors.lastname: Fritzen
mesh_terms: D002241:Carbohydrates; D055598:Chemical Phenomena; D002621:Chemistry; D006860:Hydrogen Bonding; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D000198:Spectinomycin / Q000031:analogs & derivatives; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D002241:Carbohydrates; D000198:Spectinomycin