Suppression of HIV p24 antigen and induction of HIV anti-p24 antibody by alpha interferon in patients with chronic hepatitis B.
Five HIV p24 antigen (p24Ag)-positive patients received alpha interferon during trials of therapy for hepatitis B. Four of these showed marked falls in p24Ag during treatment. One of the two patients who became p24Ag-negative [corrected] developed anti-p24 antibodies (anti-p24). Five out of nine p24Ag-negative HIV-antibody-positive patients showed a rise in anti-p24 titres during interferon therapy, whereas only two out of six untreated controls showed a similar rise. This study provides evidence that alpha interferon has anti-HIV activity in vivo.
Brook
M G
MG
Department of Infectious Diseases, Royal Free Hospital, London, UK.
Gor
D
D
Forster
S M
SM
Harris
W
W
Jeffries
D J
DJ
Thomas
H C
HC
D000328:Adult; D002986:Clinical Trials as Topic; D015483:HIV Antibodies / Q000096:biosynthesis*; D015488:HIV Antigens / Q000032:analysis; D016655:HIV Core Protein p24; D006679:HIV Seropositivity / Q000150:complications / Q000628:therapy*; D006509:Hepatitis B / Q000150:complications / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008875:Middle Aged; D011897:Random Allocation; D012191:Retroviridae Proteins / Q000276:immunology
D015483:HIV Antibodies; D015488:HIV Antigens; D016655:HIV Core Protein p24; D007370:Interferon Type I; D012191:Retroviridae Proteins