title: 15-Hydroxycyproterone acetate and cyproterone acetate levels in plasma and urine.
abstract: 15 beta-Hydroxycyproterone acetate (15HOCPA) and cyproterone acetate (CPA) have been quantitated in human plasma and urine by a selective high-performance liquid chromatographic assay. The levels of 15HOCPA in plasma are generally twice those of its precursor CPA, although both compounds appear to have similar clearance rates. Approximately 6% of the dose is excreted into the urine, predominantly (greater than 90%) as the free form of 15HOCPA and CPA.
authors.forename: R G
authors.initials: RG
authors.lastname: Frith
authors.forename: G
authors.initials: G
authors.lastname: Phillipou
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000652:urine; D017373:Cyproterone Acetate / Q000031:analogs & derivatives; D005260:Female; D005965:Glucuronates / Q000032:analysis; D006801:Humans; D011863:Radioimmunoassay
chemical_list: D005965:Glucuronates; C045999:15-hydroxycyproterone acetate; D017373:Cyproterone Acetate; D003534:Cyproterone