Percutaneous absorption of sulconazole nitrate in humans.
The percutaneous absorption of 1% sulconazole nitrate in a cream formulation containing 3H-labeled drug has been studied in seven human subjects. Two applications of 4.5 g each were made to 450 cm2 of abdominal skin at 0 and 12 h, and the site was washed at 24 h. The application site was subsequently washed at 24-h intervals for 3 consecutive days, and 6.7% of the dose was recovered in the urine and 2.0% in the feces following a 7-d collection period. Radioactivity was detectable in the plasma from 8-96 h, with a peak occurring at 24 h, and could also be recovered in the skin wash up to 96 h after application. Total percutaneous absorption of sulconazole was estimated to be 8.7-11.3% of the applied dose, considerably more than that previously reported for other imidazole drugs.
Franz
T J
TJ
Dermatopharmacology Laboratory, University of Washington, School of Medicine, Seattle 98195.
Lehman
P
P
D000328:Adult; D000818:Animals; D000935:Antifungal Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D005243:Feces / Q000032:analysis; D006801:Humans; D007093:Imidazoles / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D008253:Macaca mulatta; D008297:Male; D012869:Skin Absorption
D000935:Antifungal Agents; D007093:Imidazoles; C033308:sulconazole