[Effect of intravenous administration of fat emulsion to depancreatized dogs].
Sixteen mongrel dogs were depancreatized and controlled with intravenous hyperalimentation that included fat emulsion (Intralipid) for four weeks. Plasma lipids, fat tolerance test, PHLA, and presence of fatty liver were investigated. Dogs were divided into three groups (A, B, and C) for the purpose of studying the effect of fat emulsion. Groups A(n = 6) and B(n = 5) were given fat emulsion 1g/kg/day and 2g/kg/day respectively. Group C(n = 5) was not given fat emulsion. Group B had increased plasma total cholesterol and phospholipid. Group A had a slight increase of TG only. Group C had decreased plasma total cholesterol and phospholipid, and became hypoglycemic sometimes. The ability to clear fat emulsion expressed as (K2) decreased significantly after the 14th day in group B only. LPL, determined by the PHLA test in groups B and C only, did not change significantly. It seemed that fat emulsion was utilized in part as FFA and ketone bodies. Infusion of fat emulsion did not lead to fatty liver when insulin was administered continuously. For the depancreatized condition, it appeared that fat emulsion could be useful when blood sugar was controlled with insulin.
Tsubakimoto
R
R
Second Department of Surgery, Kinki University School of Medicine, Osaka, Japan.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004285:Dogs; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D005234:Fatty Liver / Q000209:etiology; D007262:Infusions, Intravenous; D007328:Insulin / Q000494:pharmacology; D010180:Pancreatectomy; D010289:Parenteral Nutrition, Total; D010743:Phospholipids / Q000097:blood; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D005217:Fat Emulsions, Intravenous; D007328:Insulin; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol