The use of antiserotonergic agents for the treatment of acute hemorrhagic shock of cats.
In cats anesthetized with pentobarbitone sodium the effect of two types of antiserotonergic agents on cardiovascular recuperation after acute hemorrhage was examined. Methysergide, a competitive inhibitor for 5-HT receptors and p-chlorophenylalanine (PCPA), an inhibitor of tryptophan-5-hydroxylase, improved blood pressure recovery after bleeding. After extensive hemorrhage (40 ml/kg blood), treatment with methysergide improved survival. It is proposed that serotonin participates in the depressor response and survival of acute hypovolemic hypotension.
Elam
R
R
Bergmann
F
F
Feuerstein
G
G
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002415:Cats; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000503:physiopathology
D012702:Serotonin Antagonists; D010134:Fenclonine; D008784:Methysergide