Translocation 5;21 and interstitial deletion of chromosome 7 in a case of chronic myelomonocytic leukemia.
We report a case of chronic myelomonocytic leukemia with a translocation involving chromosome 5 and 21, namely, t(5;21)(q35.3;q22.1), and an interstitial deletion of the long arm of chromosome 7. High-resolution analysis at the 900-band stage has shown that the lesion in chromosome 7 is an interstitial deletion involving loss of the segments q22-q35 of the long arm of chromosome 7 and retaining the telomere.
Sherrington
P D
PD
Department of Haematological Medicine, University of Cambridge, England.
Nacheva
E
E
Fischer
P
P
Rees
J K
JK
Hoyle
C
C
Dyer
M
M
Harper
P
P
Knight
C
C
Hayhoe
F G
FG
D000368:Aged; D000369:Aged, 80 and over; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002891:Chromosomes, Human, Pair 21; D002895:Chromosomes, Human, Pair 5; D002897:Chromosomes, Human, Pair 7; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic
D005819:Genetic Markers