Rearrangement and transcription of the beta-chain genes of the T-cell antigen receptor in different types of murine lymphocytes.
Rearrangements of T-cell receptor beta-chain genes are usually found on both chromosomal homologues, occurring by both deletional and non-deletional mechanisms. Two constant-region (C beta) genes have been identified previously and at least one is transcribed in every helper or cytotoxic T cell tested, but the choice of C beta gene expression is not correlated with the specialized functions of these T lymphocytes. By contrast, four of five suppressor T-cell hybridomas examined have deleted all known joining (J beta) gene segments and C beta genes and therefore may have antigen receptors encoded by different T-cell receptor gene families.
Kronenberg
M
M
Goverman
J
J
Haars
R
R
Malissen
M
M
Kraig
E
E
Phillips
L
L
Delovitch
T
T
Suciu-Foca
N
N
Hood
L
L
D000818:Animals; D002872:Chromosome Deletion; D005796:Genes; D008223:Lymphoma / Q000503:physiopathology; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D011995:Recombination, Genetic; D013601:T-Lymphocytes / Q000502:physiology*; D013602:T-Lymphocytes, Cytotoxic / Q000502:physiology; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology; D014158:Transcription, Genetic
D011948:Receptors, Antigen, T-Cell