title: [Clinical application of microfibrillar collagen hemostat (Avitene) in neurosurgical field].
abstract: Microfibrillar collagen hemostat (Avitene) is a new absorbable hemostatic agent, of which mechanisms are adhesion to the bleeding site and platelet aggregation. Histopathological examinations revealed that Avitene was biocompatible with cerebral cortex in an animal experiments. Our previous studies indicated that Avitene is very effective and safe to use as a topical hemostatic agent during craniotomy in an experimental animal. Avitene was used as a topical hemostatic agent during craniotomy in 36 patients with intracranial organic lesions. Its effectiveness of hemostasis was revealed in 95%. This agent was especially useful to prevent oozing during craniotomy. Side effect of this agent was not reported in this study. Therefore, Avitene is very effective and safe to use as a topical hemostatic agent in the neurosurgical field.
authors.affiliation: Department of Neurosurgery, Jikei University School of Medicine.
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: H
authors.initials: H
authors.lastname: Sakai
authors.forename: S
authors.initials: S
authors.lastname: Yasue
authors.forename: I
authors.initials: I
authors.lastname: Nagayama
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: N
authors.initials: N
authors.lastname: Basugi
authors.forename: K
authors.initials: K
authors.lastname: Kim
authors.forename: K
authors.initials: K
authors.lastname: Kitamura
authors.forename: M
authors.initials: M
authors.lastname: Yoshimasu
mesh_terms: D001921:Brain / Q000601:surgery*; D001932:Brain Neoplasms / Q000601:surgery; D002561:Cerebrovascular Disorders / Q000601:surgery; D003094:Collagen / Q000627:therapeutic use*; D003399:Craniotomy; D004388:Dura Mater / Q000601:surgery; D005260:Female; D006490:Hemostatics; D006801:Humans; D008297:Male
chemical_list: D006490:Hemostatics; D003094:Collagen