[Severe quantitative bone marrow insufficiency: results of treatment with high-dose antilymphocyte serum].
Nineteen patients with severe aplastic anaemia were treated with 21 courses of horse antithymocyte globulins (ATG). Changes in haematological parameters were correlated with ATG dosage. One of the 11 patients who received less than 100 mg/kg is still alive after more than 12 months. One of the 10 patients who received more than 100 mg/kg died of infection; in the remaining 9 patients, treatment resulted in increase or even return to normal of haemoglobin, polymorphonuclear and platelet levels. None of these 9 patients relapsed during a median follow-up of 16 months (range: 7 to 35 months). Immediate drug tolerance and serum sickness were unrelated to ATG dosage. These results confirm the therapeutic effectiveness of antithymocytic globulins in severe aplastic anaemia; they also suggest that 150 mg/kg doses are required to obtain satisfactory and long-lasting results.
Coiffier
B
B
Vuvan
H
H
Sebban
C
C
Fière
D
D
Ffrench
M
M
Guyotat
D
D
Trillet
V
V
Bryon
P A
PA
Viala
J J
JJ
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000188:drug therapy*; D000818:Animals; D000961:Antilymphocyte Serum / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001772:Blood Cell Count; D005260:Female; D006736:Horses; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors
D000961:Antilymphocyte Serum
Insuffisances médullaires quantitatives sévères: résultats du traitement par sérum antilymphocytaire à fortes doses.