A t (11;21) (13;q22) in Ph-positive chronic myelogenous leukemia.
Reciprocal translocations, in addition to that of the Ph chromosome, though rare, have been reported in chronic myelogenous leukemia (CML). We describe here a case of Ph-positive CML with a new translocation, t (11;21) (q13;q22), and missing Y, which were present both during transformation to the blastic crisis and in the subsequent reversion to the chronic phase. The possible significance of this abnormality is discussed.
Wang
T Y
TY
Department of Genetics and Endocrinology, Roswell Park Memorial Institute, Buffalo, New York.
Raza
A
A
Sait
S N
SN
Stein
A
A
Schumer
J
J
Sandberg
A A
AA
D000368:Aged; D001752:Blast Crisis / Q000235:genetics / Q000473:pathology; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D002891:Chromosomes, Human, Pair 21; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D008297:Male; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic
D005819:Genetic Markers