title: Effects of increased pulmonary vascular tone on gas exchange in canine oleic acid pulmonary edema.
abstract: Pulmonary gas exchange was investigated before and after an increase in pulmonary vascular tone induced by administration of acetylsalicylic acid (ASA), indomethacin, or almitrine in 32 pentobarbital-anesthetized and ventilated (fraction of inspired O2 0.4) dogs with oleic acid lung injury. Pulmonary vascular tone was evaluated by five-point pulmonary arterial pressure (PAP)/cardiac index (Q) plots and intrapulmonary shunt was measured using a SF6 infusion. PAP/Q plots were rectilinear in all experimental conditions. In control dogs (n = 8), oleic acid (0.09 ml/kg iv) increased PAP over the range of Q studied (1-5 l.min-1.m-2). At the same Q, arterial PO2 fell from 186 +/- 11 to 65 +/- 8 (SE) Torr and intrapulmonary shunt rose from 5 +/- 1 to 50 +/- 6% 90 min after oleic acid injection. These changes remained stable during the generation of two consecutive PAP/Q plots. ASA (1 g iv, n = 8), indomethacin (2 mg/kg iv, n = 8), and almitrine (8 micrograms.kg-1.min-1 iv, n = 8) produced a further increase in PAP at each level of Q. ASA and indomethacin, respectively, increased arterial PO2 from 61 +/- 4 to 70 +/- 3 Torr (P less than 0.05) and from 70 +/- 6 to 86 +/- 6 Torr (P less than 0.05) and decreased intrapulmonary shunt from 61 +/- 5 to 44 +/- 4% (P less than 0.05) and from 44 +/- 5 to 29 +/- 4% (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Respiratory Research Unit, Erasme University Hospital, Brussels, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Leeman
authors.forename: P
authors.initials: P
authors.lastname: Lejeune
authors.forename: R
authors.initials: R
authors.lastname: Hallemans
authors.forename: C
authors.initials: C
authors.lastname: Mélot
authors.forename: R
authors.initials: R
authors.lastname: Naeije
mesh_terms: D015765:Almitrine; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D001784:Blood Gas Analysis; D001794:Blood Pressure; D002302:Cardiac Output; D004285:Dogs; D007213:Indomethacin / Q000494:pharmacology; D008168:Lung / Q000098:blood supply* / Q000187:drug effects / Q000503:physiopathology; D019301:Oleic Acid; D009829:Oleic Acids; D010100:Oxygen / Q000097:blood; D010879:Piperazines / Q000494:pharmacology; D011654:Pulmonary Edema / Q000139:chemically induced / Q000503:physiopathology*; D011659:Pulmonary Gas Exchange; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D009829:Oleic Acids; D010879:Piperazines; D019301:Oleic Acid; D015765:Almitrine; D001241:Aspirin; D010100:Oxygen; D007213:Indomethacin