Concentration and localization of carbohydrate antigen 19-9 in tissues of pancreatic cancer.
Carbohydrate antigen (CA) 19-9 concentration in the tissue-extracts of cancerous and noncancerous pancreatic tissues were determined by radioimmunoassay. Pancreatic cancer tissues revealed significantly elevated CA 19-9 concentrations, when compared with chronic pancreatitis, normal adult pancreas, or fetal pancreas tissues. Metastatic liver tumors from pancreatic cancer also showed extremely high CA 19-9 concentrations, and there was no significant correlation between tissue CA 19-9 concentration and serum CA 19-9 level in patients with pancreatic cancer. In addition, positive localization of CA 19-9 was clearly observed in cancer cells of pancreatic cancerous tissues by immunohistochemical study, confirming the remarkable increase of CA 19-9 concentration in tissues of pancreatic cancer, although CA 19-9 was also partially found in non-malignant pancreatic tissues. The results indicated that CA 19-9 would be produced in great quantities by cancer cells in tissues of pancreatic cancer, and thus could be a valuable tumor associated antigen suggesting its clinical use as a tumor marker for cancer of the pancreas.
Nishida
K
K
Shakaihoken Kobe Central Hospital, Japan.
Miyagawa
H
H
Yoshikawa
T
T
Kondo
M
M
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor / Q000032:analysis*; D004067:Digestive System Neoplasms / Q000032:analysis; D005756:Gastritis / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000032:analysis / Q000196:embryology; D008107:Liver Diseases / Q000378:metabolism; D010179:Pancreas / Q000032:analysis / Q000196:embryology; D010190:Pancreatic Neoplasms / Q000032:analysis* / Q000276:immunology; D051381:Rats; D013274:Stomach Neoplasms / Q000032:analysis
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor