Prospective study of childhood acute lymphocytic leukemia: hematologic, immunologic, and cytogenetic correlations.
We studied the karyotype in 81 consecutively diagnosed children with acute lymphocytic leukemia (ALL) treated at one institution on a randomized treatment protocol. In 75 patients (93%), a morphological cytogenetic result was obtained, and 57 (65%) were successfully G-banded. Of the 75 patients, 46 (61%) showed abnormal chromosomes, mainly hyperdiploidy and pseudodiploidy, and 29 had no detectable abnormality. Our findings confirmed that the karyotype has prognostic significance. Duration of complete remission was 93% at 42 months for patients with high hyperdiploidy (greater than 50). For patients with an apparently normal karyotype, it was 58%; and for patients with structural abnormalities it was 15%. The significance of these findings was confirmed by multivariate analysis, which showed age and karyotype to be the most important determinants of duration of remission.
Michael
P M
PM
University of Melbourne Department of Medicine, St. Vincent's Hospital, Australia.
Garson
O M
OM
Ekert
H
H
Tauro
G
G
Rennie
G C
GC
Pilkington
G R
GR
D002648:Child; D002869:Chromosome Aberrations / Q000453:epidemiology*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002877:Chromosomes, Human / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000276:immunology / Q000401:mortality; D008297:Male; D010641:Phenotype; D011003:Ploidies; D011379:Prognosis; D011446:Prospective Studies; D012074:Remission Induction