Translocation t(1;22) in congenital acute megakaryocytic leukemia.
Acquired chromosomal abnormalities have been reported in 80 patients with congenital acute leukemia, the commonest being t(4;11). We report here a case of acute megakaryocytic leukemia with a rare translocation of t(1;22)(p13.3;q13.3). The course of the disease was short, with the patient surviving less than a year after the initial diagnosis.
Sait
S N
SN
Cancer Center, Southwest Biomedical Research Institute, Scottsdale, AZ 85251.
Brecher
M L
ML
Green
D M
DM
Sandberg
A A
AA
D002878:Chromosomes, Human, Pair 1; D002892:Chromosomes, Human, Pair 22; D005819:Genetic Markers; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D007947:Leukemia, Megakaryoblastic, Acute / Q000151:congenital* / Q000235:genetics; D008297:Male; D014178:Translocation, Genetic
D005819:Genetic Markers