title: Karyotypic evidence for the leukemic involvement of the erythroblasts in erythroleukemia.
abstract: With the use of a monoclonal anti-glycophorin A antibody and flow cytometric cell sorting, an erythroleukemic bone marrow sample was separated in highly purified erythroblast and myeloblast fractions. Similar karyotypic anomalies were found in both cell populations as in the unseparated bone marrow. This study confirms that acute nonlymphocytic leukemia can originate at the level of a multipotential hemopoietic stem cell.
authors.affiliation: Laboratory of Hematology, University of Antwerp, Belgium.
authors.forename: Z N
authors.initials: ZN
authors.lastname: Berneman
authors.forename: D R
authors.initials: DR
authors.lastname: van Bockstaele
authors.forename: M
authors.initials: M
authors.lastname: Van den Bergh
authors.forename: B
authors.initials: B
authors.lastname: Van Roy
authors.forename: L
authors.initials: L
authors.lastname: Roete
authors.forename: R
authors.initials: R
authors.lastname: De Bock
authors.forename: M
authors.initials: M
authors.lastname: Korthout
authors.forename: M E
authors.initials: ME
authors.lastname: Peetermans
authors.forename: J
authors.initials: J
authors.lastname: Dumon
mesh_terms: D000911:Antibodies, Monoclonal; D001854:Bone Marrow Cells; D002469:Cell Separation; D004900:Erythroblasts / Q000032:analysis*; D005434:Flow Cytometry; D006021:Glycophorins / Q000032:analysis; D006801:Humans; D007621:Karyotyping; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D000911:Antibodies, Monoclonal; D006021:Glycophorins