Fate of primary orbital dermis-fat grafts in guinea pigs.
A year-long study was undertaken to serially evaluate the tissue changes occurring in dermis-fat graft (DFG) after orbital implantation in nine guinea pigs. Methods used to evaluate the DFGs were histology, magnetic resonance imaging, morphometric analysis, and clinical observations. The histology of a 1-year-old failed human dermis-fat graft has been included for completeness. The study reveals that clinically successful DFGs have a fibrous capsule surrounding the DFG. Minimal revascularization was present. The grafts appear to undergo continual histological changes for approximately 9 months before a steady-state condition ensues. Of interest are changes in the deep-orbital fat posterior to the DFG.
Smith
B R
BR
Department of Opthalmology, Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston.
Beyer-Machule
C K
CK
Cheng
H M
HM
Pitts
W C
WC
D000273:Adipose Tissue / Q000473:pathology / Q000637:transplantation*; D000818:Animals; D015353:Eye Enucleation; D006085:Graft Survival; D006168:Guinea Pigs; D008279:Magnetic Resonance Imaging; D009915:Orbit / Q000601:surgery*