Renal function and blood pressure in patients treated with cyclosporin A for uveitis.
Renal function has been evaluated in 21 patients treated with cyclosporin A (CyA) for 9 months for idiopathic uveitis. Serum creatinine, which was 82 mumol.l-1 before treatment, was significantly elevated after 1 month (111 mumol.l-1). After 9 months of treatment, and despite a decrease in CyA dosage, the mean plasma creatinine remained elevated at 132 mumol.l-1. Hypertension developed in 6 patients, five of them being concomitantly treated with corticosteroids. In 8 patients serum creatinine 3 months after CyA had been stopped had decreased from 148 to 93 mumol.l-1. Two of those patients remained hypertensive 3 months after CyA treatment had ceased. In patients with idiopathic uveitis CyA induces a reversible increase in serum creatinine. However the reversibility of such a biochemical marker does not preclude a histopathological lesion. Chronic renal damage may be responsible for the persistence of hypertension after cessation of CyA treatment.
Deray
G
G
Department of Nephrology, Hôpital Pitié-Salpétrière, Paris, France.
Le Hoang
P
P
Cacoub
P
P
Aupetit
B
B
Mertani
A
A
Martinez
F
F
Rottembourg
J
J
D000328:Adult; D001327:Autoimmune Diseases / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D013997:Time Factors; D014605:Uveitis / Q000188:drug therapy*
D003524:Cyclosporins; D003404:Creatinine; D011188:Potassium