title: Preparation of anesthesia machines for patients susceptible to malignant hyperthermia.
abstract: Malignant hyperthermia is a potentially lethal syndrome that can be triggered by inhaled anesthetics. Thus, it may be appropriate to utilize equipment that minimizes exposure of susceptible patients to inhaled anesthetics. The rate of release of anesthetic stored in anesthesia delivery systems is unknown. To determine residual anesthetic concentrations, the washout rates of halothane and isoflurane were compared, and the effects of a 1-l/min and a 10-l/min fresh gas flow were evaluated. Halothane concentrations were also measured in samples taken from the fresh gas outlet and the Y-piece of the circle system during four separate studies in which various components of the anesthesia system were replaced. In each study an Ohio Modulus anesthesia machine equipped with an Air-Shields ventilator was exposed to 2% halothane for 18 h. Anesthetic concentrations were determined by a gas chromatograph having a sensitivity of 0.1 ppm. Isoflurane washed out 3-4 times faster than halothane. Residual halothane concentration was approximately equal to tenfold greater when the fresh gas flow was 1 l/min rather than 10 l/min: 194 versus 19 ppm after 1 h of washout. Using a 10-l/min fresh gas flow, halothane concentrations in samples obtained from the Y-piece were similar with original or fresh soda lime but were more than tenfold lower after the fresh gas outlet hose and circle system were replaced (approximately equal to 50 ppm vs. approximately equal to 5 ppm after 5 min of washout).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesia, University of California, San Francisco 94143-0648.
authors.forename: J J
authors.initials: JJ
authors.lastname: Beebe
authors.forename: D I
authors.initials: DI
authors.lastname: Sessler
mesh_terms: D000769:Anesthesia, Inhalation / Q000295:instrumentation; D000776:Anesthesiology / Q000295:instrumentation*; D002849:Chromatography, Gas; D004198:Disease Susceptibility; D004866:Equipment Contamination / Q000517:prevention & control; D005069:Evaluation Studies as Topic; D006221:Halothane / Q000032:analysis; D006801:Humans; D007530:Isoflurane / Q000032:analysis; D008305:Malignant Hyperthermia / Q000517:prevention & control*; D013997:Time Factors; D012122:Ventilators, Mechanical
chemical_list: D007530:Isoflurane; D006221:Halothane