Effect of human gamma interferon on yellow fever virus infection.
We studied yellow fever virus infection in two species of monkey: Saimiri sciureus (squirrel monkeys) and Macaca mulatta (rhesus monkeys). Human gamma interferon was administered intravenously in five equal doses, one was given 24 hr before infection followed by four doses 24 hr apart. Interferon reduced the levels and duration of viremia and the severity of hepatitis in squirrel monkeys. Interferon prolonged survival time and delayed the appearance of viremia and hepatitis in infected rhesus monkeys, but it did not change overall mortality.
Arroyo
J I
JI
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut.
Apperson
S A
SA
Cropp
C B
CB
Marafino
B J
BJ
Monath
T P
TP
Tesh
R B
RB
Shope
R E
RE
Garcia-Blanco
M A
MA
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007275:Injections, Intravenous; D007371:Interferon-gamma / Q000008:administration & dosage / Q000627:therapeutic use*; D008253:Macaca mulatta; D011897:Random Allocation; D012453:Saimiri; D014766:Viremia / Q000628:therapy*; D015004:Yellow Fever / Q000628:therapy*
D007371:Interferon-gamma; D000410:Alanine Transaminase