Lipopolysaccharide tolerance inhibits eye inflammation. II. Preliminary studies on the mechanism.
The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. Compared with a control group, a passive Arthus reaction in tolerant rabbits was characterized by a sharp decline in the expected increase in vascular permeability and slightly reduced leukocyte extravasation. Aqueous humor withdrawal (paracentesis) and intravitreal injection of prostaglandin E2 were also examined in lipopolysaccharide (LPS)-tolerant rabbits; in both circumstances, ocular protein exudation was decreased. These studies suggest that the prostaglandin system is particularly affected in the ocular responses of LPS-tolerant rabbits, and raise the possibility that other phenomena described in LPS tolerance may have a similar basis.
Howes
E L
EL
Rosenbaum
J T
JT
D000818:Animals; D000917:Antibody Formation; D001082:Aqueous Humor; D001183:Arthus Reaction / Q000276:immunology / Q000473:pathology; D002199:Capillary Permeability; D015232:Dinoprostone; D004361:Drug Tolerance; D005123:Eye / Q000098:blood supply; D008070:Lipopolysaccharides / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011817:Rabbits; D012486:Salmonella typhimurium; D014606:Uveitis, Anterior / Q000209:etiology / Q000276:immunology / Q000473:pathology*
D008070:Lipopolysaccharides; D011458:Prostaglandins E; D015232:Dinoprostone