A relationship between prolactin levels and dexamethasone suppression test results in major depressive disorder.
Fifteen patients with a major depressive disorder and 20 control subjects have completed a 1 mg Dexamethasone Suppression Test (DST) and on a separate day have had their prolactin and cortisol levels measured at 16.00 h. Among the depressed patients there was a significant positive correlation between the DST cortisol and the prolactin level, with abnormally elevated prolactin levels occurring in those depressed patients with very high DST cortisol (greater than 400 nmol/l) levels.
Joyce
P R
PR
Donald
R A
RA
Livesey
J H
JH
D000328:Adult; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis*; D003907:Dexamethasone; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D011388:Prolactin / Q000097:blood*
D003907:Dexamethasone; D011388:Prolactin; D006854:Hydrocortisone