Fluphenazine decanoate. Its steady-state pharmacologic profile and relationship to tardive dyskinesia.
A sensitive radioimmunoassay was developed to determine the steady-state, fixed-dose pharmacokinetic profile of fluphenazine decanoate in nine outpatients. To see if neuroleptic blood levels measured by this assay correlated with a clinical event, we performed a cross-sectional study of fluphenazine blood levels in 11 patients with and 17 patients without tardive dyskinesia. The results do not support the hypothesis that fluphenazine decanoate serum levels correlate with TD occurrence.
Glazer
W M
WM
Yale University School of Medicine, Department of Psychiatry, New Haven, CT 06519.
D000328:Adult; D004409:Dyskinesia, Drug-Induced / Q000097:blood / Q000378:metabolism*; D005260:Female; D005476:Fluphenazine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D006801:Humans; D008297:Male
C011825:fluphenazine depot; D005476:Fluphenazine