In vitro activity of enoxacin compared with norfloxacin and amikacin.
The in vitro activity of enoxacin was tested against 1000 clinical isolates of gram-positive and gram-negative microorganisms and compared with that of norfloxacin and amikacin. The MIC90 of enoxacin was 1 mg/l for Enterobacteriaceae, 2.6 mg/l for Pseudomonas aeruginosa and 6.2 mg/l or Staphylococcus aureus. The inoculum effect was minimal. The MICs and MBCs for Pseudomonas aeruginosa strains were significantly affected by the addition of calcium and magnesium ions. Synergy was occasionally observed between enoxacin and the antibiotics tested; antagonism was rare.
van der Auwera
P
P
de Moor
G
G
Lacroix
G
G
Mambour
A
A
Rossion
N
N
Schuyteneer
F
F
D000583:Amikacin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002118:Calcium / Q000494:pharmacology; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D015365:Enoxacin; D004755:Enterobacteriaceae / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D007612:Kanamycin / Q000031:analogs & derivatives*; D008274:Magnesium / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D009287:Naphthyridines / Q000494:pharmacology*; D009643:Norfloxacin; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D009287:Naphthyridines; D015365:Enoxacin; D009268:Nalidixic Acid; D007612:Kanamycin; D000583:Amikacin; D008274:Magnesium; D009643:Norfloxacin; D002118:Calcium