Acute leukemia characterized by trisomy 8 in Down's syndrome.
Of the myeloproliferative disorders which develop in Down's syndrome, acute leukemia associated with trisomy 8 has distinct characteristics. It is non-lymphoblastic in type and has a preleukemia phase in which thrombocytopenia is a prominent feature. One case occurring in a 20 mth-old girl is reported and 3 other similar cases reviewed. Acquired trisomy 8 in Down's syndrome is linked to leukemogenesis and confers non-lymphoblastic differentiation.
Broomhead
A F
AF
Kwan
Y L
YL
Zell
N A
NA
Lam-Po-Tang
P R
PR
O'Gorman Hughes
D
D
D002906:Chromosomes, Human, 6-12 and X; D004314:Down Syndrome / Q000150:complications* / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007938:Leukemia / Q000150:complications* / Q000235:genetics; D014314:Trisomy