Fibrous papules. A light microscopic and immunohistochemical study.
Thirty-six cases of fibrous papules of the face and nose were studied by light microscopy and by immunohistochemistry. Positive staining with antibodies to vimentin and negative staining with antibodies to S-100 protein, alpha 1-antichymotrypsin, and factor VIII-RAG of the spindle, stellate, and multinucleated cells observed in the dermis support a fibroblastic line of differentiation. Fibrous papules of the nose and face are a distinctive clinicopathologic entity that most probably represents an inflammatory rather than a neoplastic process, sharing some histologic features of angiofibromas (angiofibrosis) and perifollicular fibromas (perifollicular fibrosis).
Rosen
L B
LB
Department of Pathology, Mount Sinai Medical Center, Miami Beach, FL 33140.
Suster
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000941:Antigens / Q000032:analysis; D005148:Facial Dermatoses / Q000473:pathology*; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D005260:Female; D005355:Fibrosis; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009666:Nose / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis; D000514:alpha 1-Antichymotrypsin / Q000032:analysis; D014841:von Willebrand Factor / Q000032:analysis
D000941:Antigens; D009418:S100 Proteins; D014746:Vimentin; D000514:alpha 1-Antichymotrypsin; D014841:von Willebrand Factor; D005169:Factor VIII