[Testicular follicle-stimulating hormone receptors and effectiveness of human menopausal gonadotropin-human chorionic gonadotropin treatment in idiopathic male infertility].
To investigate the relationship between testicular follicle stimulating hormone (FSH) receptors and the effectiveness of human menopausal gonadotropin (hMG-hCG) treatment in idiopathic male infertility, 48 infertile men were examined. Most of the 14 patients without detectable testicular high affinity FSH receptors did not show any increase in sperm count after the hMG-hCG treatment, whereas 23 of the 34 patients with FSH receptors responded to the treatment. In patients with FSH receptors, patients with a middle or high Johnsen's score count responded more than those with a low score count did. From the above results, it seems that both the presence or absence of testicular FSH receptors and the histological appearance of spermatogenesis predict responsiveness to hMG-hCG treatment in infertile men.
Namiki
M
M
Department of Urology, Osaka University Medical School.
Nakamura
M
M
Okuyama
A
A
Sonoda
T
T
Doi
Y
Y
Matsui
T
T
Fujisue
H
H
Takeyama
M
M
Fujioka
H
H
Hayashi
T
T
D000328:Adult; D001665:Binding Sites; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy*; D008297:Male; D008596:Menotropins / Q000627:therapeutic use*; D008875:Middle Aged; D011962:Receptors, FSH / Q000187:drug effects* / Q000502:physiology; D013091:Spermatogenesis; D013737:Testis / Q000032:analysis
D006063:Chorionic Gonadotropin; D011962:Receptors, FSH; D008596:Menotropins