Skin graft rejection caused by the maternally transmitted antigen Mta.
Mta is a medial histocompatibility antigen of the mouse. It does not stimulate a primary mixed lymphocyte response and stimulates only a very weak secondary response. Primary skin grafts are rejected with a mean survival time of 59 days by Mta- NZB recipients, and 39 days by recipients of the C57BL/6 background. Rejection is accelerated in recipients primed against Mta with a skin graft or cells, especially when these differ by multiple minor histocompatibility antigens. Mta is determined by a maternally transmitted, extrachromosomal genetic element, so backcross mice reject skin from their inbred, homozygous paternal strain. Mta, therefore, constitutes a new exception to the classic laws of transplantation.
Chan
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Fischer Lindahl
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D000818:Animals; D006084:Graft Rejection; D006649:Histocompatibility Antigens / Q000235:genetics; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*; D012867:Skin / Q000276:immunology; D016038:Skin Transplantation
D006649:Histocompatibility Antigens