Effects of ketoprofen and other drugs on release of prostaglandins from uterus of rabbits in perinatal period.
The effects of oral administration of ketoprofen, naproxen, flurbiprofen (1.0 mg/kg), indomethacin (1.0 and 3.0 mg/kg), and acetylsalicylic acid (100 mg/kg) on release of prostaglandin F2 alpha (PGF2 alpha) and prostaglandin E (PGE) from isolated pregnant rabbit uterus were studied comparatively. Ketoprofen, indomethacin, flurbiprofen, naproxen and acetylsalicylic acid reduced the release of PGF2 alpha and PGE from the isolated rabbit uterus. The inhibitory effect was most profound with flurbiprofen, followed, in order, by naproxen, ketoprofen, indomethacin and acetylsalicylic acid. A comparative study with intramuscular ketoprofen (0.1, 1.0 and 3.0 mg/kg) was also carried out. The inhibitory effect of ketoprofen on uterine PGF2 alpha and PGE release with intramuscular route was about 10 times more profound than that with oral route.
Ueno
K
K
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Masumura
H
H
Kawamoto
H
H
Kitagawa
H
H
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D015237:Dinoprost; D005260:Female; D066298:In Vitro Techniques; D007660:Ketoprofen / Q000494:pharmacology*; D010666:Phenylpropionates / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism*; D011460:Prostaglandins F / Q000378:metabolism*; D011817:Rabbits; D011863:Radioimmunoassay; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates; D011458:Prostaglandins E; D011460:Prostaglandins F; D007660:Ketoprofen; D015237:Dinoprost