[Dynamics of postnatal histogenesis of the thyroid in normal rats and after sympathectomy].
The changes of the thyroid gland and neurocytes of the cranial sympathetic ganglia were followed in rats of different ages after guanethidine injections with the use of radioimmunological assay, electron microscopy and morphometry. The injection of 15 mg of the drug per kg of body weight within the first two weeks after birth caused the death of over 80% of the cells in the sympathetic ganglion. In the sympathectomized 15-day- and 1-month-old rats the functional activity of the thyroid gland was markedly reduced. Later on, intrathyroid hormonogenesis somewhat increases due, apparently, to partial recovery of the organ adrenergic innervation and increase in the production of thyrotropic hypophysial hormone and calcitonin.
Riashchikov
S N
SN
Glumova
V A
VA
Markov
V N
VN
Bazhenov
A N
AN
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D006145:Guanethidine; D007455:Iodine / Q000378:metabolism; D007457:Iodine Radioisotopes; D008297:Male; D009024:Morphogenesis; D051381:Rats; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000502:physiology*; D013961:Thyroid Gland / Q000254:growth & development* / Q000378:metabolism / Q000648:ultrastructure; D013963:Thyroid Hormones / Q000096:biosynthesis / Q000097:blood; D013997:Time Factors
D007457:Iodine Radioisotopes; D013963:Thyroid Hormones; D007455:Iodine; D006145:Guanethidine
Dinamika postnatal'nogo gistogeneza shchitovidnoĭ zhelezy krys v norme i pri desimpatizatsii.