title: Reduction in morphological sickling of red cells incubated with quinine.
abstract: Quinine HCl reduced the formation of reversibly sickled cells in vitro over a concentration range of 0.2-5.0 mM. Quinidine and chloroquine had similar effects. Combinations of quinine and cyanate demonstrated synergistic, antisickling properties in vitro.
authors.affiliation: Department of Pediatrics, University of South Alabama College of Medicine, Mobile 36617.
authors.forename: V N
authors.initials: VN
authors.lastname: Mankad
authors.forename: R B
authors.initials: RB
authors.lastname: Moore
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood* / Q000473:pathology; D002738:Chloroquine / Q000494:pharmacology; D003485:Cyanates / Q000494:pharmacology; D004357:Drug Synergism; D004913:Erythrocytes, Abnormal / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D011803:Quinine / Q000494:pharmacology*
chemical_list: D003485:Cyanates; D002738:Chloroquine; D011803:Quinine