Characterization of chloride uptake in Drosophila Kc cells.
Drosophila Kc cells use at least two mechanisms for chloride uptake. These transport systems can be distinguished by their kinetic properties and by their differential sensitivity to various drugs. One transport system predominates at [Cl-]o below 30 mM and is greater than fivefold more sensitive to disulfonic stilbenes than the second system. At [Cl-]o above 30 mM, the predominant uptake mechanism is inhibited by vanadate and nitrate.
Sherwood
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Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854.
John-Alder
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Sanders
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D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D002712:Chlorides / Q000493:pharmacokinetics*; D004330:Drosophila / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000494:pharmacology; D005665:Furosemide / Q000494:pharmacology; D009566:Nitrates / Q000494:pharmacology; D013997:Time Factors; D014638:Vanadates / Q000494:pharmacology
D002712:Chlorides; D005230:Fatty Acids, Nonesterified; D009566:Nitrates; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; D014638:Vanadates; D005665:Furosemide; D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid