[Hepatic involvement in the acquired immunodeficiency syndrome. Study of 20 cases].
Liver biopsies were systematically performed in 20 patients with evidence of an acquired immunodeficiency syndrome (18 with opportunistic infections, 9 with Kaposi's sarcoma). Hepatitis, related to hepatitis-B virus in 3 cases and to cytomegalovirus in 3 cases, was present in 6 of them. All patients had at least one of the three following lesions: non-specific portal inflammatory infiltration (6 cases), granulomatous lesions (12 cases), vascular abnormalities (12 cases). Among hepatic granulomatous lesions: 3 were due to acid-fast bacilli and 1 to Cryptococcus. Sinusoidal abnormality included proliferation of Küpffer cells (9 cases), sinusoidal dilatation (2 cases), peliosis (4 cases) and Kaposi's sarcoma (1 case). A relationship between these abnormalities cannot be excluded.
Devars du Mayne
J F
JF
Marche
C
C
Penalba
C
C
Vittecoq
D
D
Saimot
G
G
Cerf
M
M
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000473:pathology; D000328:Adult; D001424:Bacterial Infections / Q000382:microbiology; D005260:Female; D006505:Hepatitis / Q000382:microbiology; D006518:Hepatitis Viruses / Q000302:isolation & purification; D006525:Hepatitis, Viral, Human / Q000209:etiology; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000382:microbiology / Q000473:pathology*; D008107:Liver Diseases / Q000209:etiology* / Q000473:pathology; D008297:Male; D009181:Mycoses / Q000382:microbiology
Atteintes hépatiques au cours du syndrome d'immunodépression acquise. Etude de 20 cas.