title: Sobemovirus genome appears to encode a serine protease related to cysteine proteases of picornaviruses.
abstract: A putative serine protease was identified among non-structural proteins of southern bean mosaic virus (SBMV) by sequence comparison with cellular and viral proteases. The predicted SBMV protease displayed a significant similarity to cysteine proteases of picornaviruses, providing a possible evolutionary link between the two enzyme classes. It is suggested that SBMV follows the general expression strategy characteristic of other positive-strand RNA viruses containing 5'-terminal covalently linked proteins (VPg), i.e. generation of functional proteins by polyprotein processing.
authors.affiliation: Institute of Poliomyelitis and Viral Encephalitides, USSR Academy of Medical Sciences, Moscow Region.
authors.forename: A E
authors.initials: AE
authors.lastname: Gorbalenya
authors.forename: E V
authors.initials: EV
authors.lastname: Koonin
authors.forename: V M
authors.initials: VM
authors.lastname: Blinov
authors.forename: A P
authors.initials: AP
authors.lastname: Donchenko
mesh_terms: D000595:Amino Acid Sequence; D003546:Cysteine Endopeptidases / Q000378:metabolism; D008969:Molecular Sequence Data; D009029:Mosaic Viruses / Q000201:enzymology* / Q000235:genetics; D010849:Picornaviridae / Q000201:enzymology; D012328:RNA Viruses / Q000201:enzymology* / Q000235:genetics; D012697:Serine Endopeptidases / Q000235:genetics*
chemical_list: D012697:Serine Endopeptidases; D003546:Cysteine Endopeptidases