title: Thialysine- and selenalysine-resistance in a E. coli mutant.
abstract: A thialysine-resistant mutant of E. coli strain KL16 also shows a lower sensitivity to selenalysine, the lysine analog containing selenium. No difference between the mutant and the parental strain has been shown regarding the affinities of the transport systems and the lysyl-tRNA synthetase for selenalysine, thialysine and lysine as well as the inhibitory effects of these three aminoacids on the activity of the lysine biosynthetic pathway. A marked difference between the two strains has been evidenced in the AK III repression: in the mutant the repression by selenalysine, thialysine and lysine is much lower than in the parental strain.
authors.affiliation: Centro per lo stuido degli Acidi Nucleici-Roma, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Busiello
authors.forename: C
authors.initials: C
authors.lastname: Cini
authors.forename: R
authors.initials: R
authors.lastname: Coccia
authors.forename: A
authors.initials: A
authors.lastname: Di Girolamo
authors.forename: M
authors.initials: M
authors.lastname: Di Girolamo
mesh_terms: D001222:Aspartate Kinase / Q000096:biosynthesis; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004794:Enzyme Repression; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D007700:Kinetics; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008250:Lysine-tRNA Ligase / Q000378:metabolism; D009154:Mutation; D016566:Organoselenium Compounds; D012643:Selenium / Q000494:pharmacology*
chemical_list: D016566:Organoselenium Compounds; C000204:S-2-aminoethyl cysteine; C011351:selenalysine; D001222:Aspartate Kinase; D008250:Lysine-tRNA Ligase; D012643:Selenium; D008239:Lysine; D003545:Cysteine