[Separation of rat serum antisuppressor antibodies eliminating T-suppressors and stimulating their generation in mice in vivo].
Immunization of rats with enriched murine specific T-suppressors (STS) permitted obtaining the antisuppressor serum (ASS) which selectively inactivated in vitro the capacity of the STS to inhibit the proliferation of T-lymphocytes in a mixed lymphocyte culture in response to allo-antigens. Two opposite effects of the ASS in vivo were demonstrated: elimination of T-suppressors (on ASS administration 4 days after immunization) and stimulation of their formation (on ASS administration before immunization or to non-immunized mice). It is assumed that the two opposite effects of the ASS in vivo are caused by two different types of antibodies to unidentified markers of STS to an antigen of differentiated STS and to an antigen expressed on their precursors.
Abronina
I F
IF
Zaĭtseva
M B
MB
Brondz
B D
BD
D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000302:isolation & purification*; D007106:Immune Sera / Q000276:immunology / Q000302:isolation & purification*; D007108:Immune Tolerance; D007114:Immunization / Q000379:methods; D007518:Isoantibodies / Q000276:immunology / Q000302:isolation & purification; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013945:Thymoma / Q000276:immunology; D013953:Thymus Neoplasms / Q000276:immunology
D000906:Antibodies; D007106:Immune Sera; D007518:Isoantibodies; C029805:Lyt antibodies
Razdelenie antisupressornykh antitel syvorotki krysy, éliminiruiushchikh T-supressory i stimuliruiushchikh ikh obrazovanie u mysheĭ in vivo.