Prediction of steady-state oxygen consumption during norepinephrine infusions in humans.
A method for predicting maximal oxygen consumption during norepinephrine infusion is described. Using the initial response and enzyme kinetics, predicted values of maximal oxygen consumption were compared with observed values and a coefficient of variation of 1.4% was obtained. This method is of use in situations where it may not be possible to achieve steady-state conditions, especially with high doses of norepinephrine, and it permits comparison of maximal oxygen consumption between groups.
Sheela
M L
ML
Department of Physiology, St John's Medical College, Bangalore, India.
Kurpad
A V
AV
Kulkarni
R N
RN
Shetty
P S
PS
D000328:Adult; D001833:Body Temperature Regulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008954:Models, Biological; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*
D009638:Norepinephrine