Effect of low-dose exogenous secretin on pentagastrin- and meal-stimulated gastric acid secretion in humans.
Intravenous infusion of secretin in a dose of 0.05 CU/kg/hr inhibited pentagastrin-stimulated (100 ng/kg/hr) acid secretion by 42% (P less than 0.05) abd meal-stimulated (10% peptone, pH 5.5) acid secretion by 33% (P less than 0.05) in 10 healthy subjects. Median serum gastrin concentration during peptone stimulation was reduced by 24% (P less than 0.05) during secretin infusion. Median plasma secretin concentrations were 6.0 and 5.2 pmol/liter, respectively. Since these secretin concentrations are of the same magnitude as those seen after duodenal acidification, it is concluded that secretin may participate in the physiological inhibition of gastric acid secretion.
Christiansen
J
J
Department of Surgery D, Glostrup Hospital, University of Copenhagen, Denmark.
Hansen
B
B
Hilsted
L
L
Schaffalitzky de Muckadell
O B
OB
D000328:Adult; D004435:Eating; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D010418:Pentagastrin / Q000037:antagonists & inhibitors*; D010461:Peptones / Q000378:metabolism; D012633:Secretin / Q000097:blood / Q000494:pharmacology*
D010461:Peptones; D012633:Secretin; D010418:Pentagastrin