[Treatment of amyotrophic lateral sclerosis with TRH].
In view of earlier reports in the literature it was tried to use TRH (thyrotropin releasing hormone) in cases of amyotrophic lateral sclerosis. TRH was given during 3 weeks once daily intravenously in drip infusions in a 0.4 mg dose. For objectivization of the results the muscle power was assessed using a five-grade scale of Lovette. TRH effect on EMG was analysed also. It was found that in only 3 out of 14 patients with moderately progressed disease no improvement was achieved, while in 11 cases the improvement was from 10 to 20%. However, the improvement was transient, and TRH treatment failed to stop the progression of the disease.
Klimek
A
A
Klinika Neurologii AM w Lodzi.
Szulc-Kuberska
J
J
Czernielewska-Rutkowska
I
I
Głuszcz-Zielińska
A
A
D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D005260:Female; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009129:Muscle Tonus / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000627:therapeutic use*
D006728:Hormones; D013973:Thyrotropin-Releasing Hormone
Leczenie stwardnienia zanikowegò bocznego przy pomocy TRH.