title: Source origin of a 50-msec latency auditory evoked field component in young schizophrenic men.
abstract: We recorded auditory evoked magnetic fields in response to 128 15-msec duration 1-KHz tone pips from both hemispheres of 6 young schizophrenic men. Auditory evoked potentials were recorded conventionally from a vertex lead. The approximately 50-msec latency component was identified in both the magnetic (M50) and electroencephalographic (EEG) (P50) recordings. Isofield topographical contour maps were used to estimate M50 source location and depth. Magnetic resonance imaging was used to identify the neuroanatomical structure(s) present at the estimated source location. M50 sources appeared to reside in the planum temporale in both left and right hemispheres in all subjects. Normal inter-hemispheric asymmetry (with respect to external bony landmarks) of the M50 source was not found in this patient group. Additionally, left (but not right) hemisphere source anatomy differed in several respects from data previously reported in normals.
authors.affiliation: Department of Psychiatry, University of Colorado Health Sciences Center, Denver 80262.
authors.forename: M
authors.initials: M
authors.lastname: Reite
authors.forename: P
authors.initials: P
authors.lastname: Teale
authors.forename: J
authors.initials: J
authors.lastname: Zimmerman
authors.forename: K
authors.initials: K
authors.lastname: Davis
authors.forename: J
authors.initials: J
authors.lastname: Whalen
authors.forename: J
authors.initials: J
authors.lastname: Edrich
mesh_terms: D000328:Adult; D001303:Auditory Cortex / Q000503:physiopathology; D001306:Auditory Pathways / Q000503:physiopathology; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011930:Reaction Time / Q000502:physiology*; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000503:physiopathology