title: Protease inhibition increases the analgesic potency of peptide E.
abstract: Peptide E (PE), an opioid peptide from adrenal medulla, is known to possess very low analgesic potency when injected intracerebroventricularly in mice. The present study showed that PE analgesia was increased by co-injection with protease inhibitors (bacitracin and bestatin).
authors.forename: M
authors.initials: M
authors.lastname: Westphal
authors.forename: R G
authors.initials: RG
authors.lastname: Hammonds
authors.forename: C H
authors.initials: CH
authors.lastname: Li
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001414:Bacitracin / Q000494:pharmacology; D004357:Drug Synergism; D004723:Endorphins / Q000037:antagonists & inhibitors*; D004745:Enkephalins; D007276:Injections, Intraventricular; D007930:Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D051379:Mice; D010455:Peptides / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000494:pharmacology*; D001615:beta-Endorphin
chemical_list: D000700:Analgesics; D004723:Endorphins; D004745:Enkephalins; D010455:Peptides; D011480:Protease Inhibitors; D001414:Bacitracin; D001615:beta-Endorphin; C039933:peptide E (adrenal medulla); D007930:Leucine; C012211:ubenimex