The effect of oral medroxyprogesterone acetate and methyltestosterone on sexual functioning in a male contraceptive trial.
Twenty-three men who participated in a 15-month clinical trial to assess the potential effectiveness of using a combination of varying doses of medroxyprogesterone acetate (MPA) and methyltestosterone (MT) as a male contraceptive agent, completed a "sexual problem checklist" every two weeks. The study was divided into three phases: pre-treatment (3 months), treatment (6 months), post-treatment (6 months). The questionnaire evaluated changes in various aspects of sexual behaviour and sexual perception and explored whether the treatment influenced any of the parameters considered. The results indicated a small, but significant, decrease in subjective assessment of sexual drive. This was not, however, accompanied by a change in sexual behaviour, in that subjects experienced the same number of erections, ejaculations and frequency of intercourse. It is concluded that the combination of MPA and MT in the doses used may produce a slight decrease in subjective assessment of sexual drive, but no change in actual sexual behaviour.
Doody
K
K
Bain
J
J
D000284:Administration, Oral; D000328:Adult; D002986:Clinical Trials as Topic; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D006801:Humans; D007989:Libido / Q000187:drug effects*; D008297:Male; D008525:Medroxyprogesterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D017258:Medroxyprogesterone Acetate; D008777:Methyltestosterone / Q000008:administration & dosage / Q000494:pharmacology*; D012725:Sexual Behavior / Q000187:drug effects*
D003271:Contraceptive Agents, Female; D004338:Drug Combinations; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone; D008777:Methyltestosterone