Cyclization of nucleotide analogues as an obstacle to polymerization.
Cyclization of activated nucleotide analogues by intramolecular phosphodiester-bond formation is likely to compete very effectively with template-directed condensation except in the cases of ribo- and arabinonucleotides. This could have excluded derivatives of most sugars from growing polyribonucleotide chains and thus reduced chain-termination in prebiotic polynucleotide synthesis.
Hill
A R
AR
Salk Institute for Biological Studies, San Diego, California 92138.
Nord
L D
LD
Orgel
L E
LE
Robins
R K
RK
D002625:Chemistry, Organic; D009711:Nucleotides; D055601:Organic Chemistry Phenomena; D011131:Polyribonucleotides / Q000138:chemical synthesis*; D013698:Templates, Genetic
D009711:Nucleotides; D011131:Polyribonucleotides