title: [Interaction of amino acyl-tRNA-synthetases from the rabbit liver with RNA and polyanions].
abstract: The interaction of aminoacyl-tRNA synthetase with RNA and polyanions was studied. The inhibition of the enzymes by polyU, polyI and heparin was demonstrated. It was found that this interaction is of limited specificity and is typical of single-stranded RNAs which possess no orderly secondary structure as well as of other polyanions possessing similar polyelectrolytic properties. Data from kinetic analysis and lysyl-tRNA synthetase modification by pyridoxal phosphate are suggestive of participation of the tRNA binding site in the enzyme interaction with polyanions.
authors.forename: A D
authors.initials: AD
authors.lastname: Vol'fson
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Motorin
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Tsygankov
authors.forename: A F
authors.initials: AF
authors.lastname: Orlovskiĭ
authors.forename: K L
authors.initials: KL
authors.lastname: Gladilin
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001126:Arginine-tRNA Ligase / Q000037:antagonists & inhibitors / Q000378:metabolism; D006493:Heparin / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008250:Lysine-tRNA Ligase / Q000037:antagonists & inhibitors / Q000378:metabolism; D011069:Poly I / Q000494:pharmacology; D011072:Poly U / Q000494:pharmacology; D000071228:Polyelectrolytes; D011108:Polymers / Q000378:metabolism*; D012343:RNA, Transfer / Q000378:metabolism*; D011817:Rabbits; D014637:Valine-tRNA Ligase / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000604:Amino Acyl-tRNA Synthetases; D001126:Arginine-tRNA Ligase; D006493:Heparin; D008250:Lysine-tRNA Ligase; D011069:Poly I; D011072:Poly U; D000071228:Polyelectrolytes; D011108:Polymers; D012343:RNA, Transfer; D014637:Valine-tRNA Ligase
vernacular_title: Vzaimodeĭstvie aminoatil-tRNK-sintetaz iz pecheni krolika s RNK i polianionami.