title: Cyclization of nucleotide analogues as an obstacle to polymerization.
abstract: Cyclization of activated nucleotide analogues by intramolecular phosphodiester-bond formation is likely to compete very effectively with template-directed condensation except in the cases of ribo- and arabinonucleotides. This could have excluded derivatives of most sugars from growing polyribonucleotide chains and thus reduced chain-termination in prebiotic polynucleotide synthesis.
authors.affiliation: Salk Institute for Biological Studies, San Diego, California 92138.
authors.forename: A R
authors.initials: AR
authors.lastname: Hill
authors.forename: L D
authors.initials: LD
authors.lastname: Nord
authors.forename: L E
authors.initials: LE
authors.lastname: Orgel
authors.forename: R K
authors.initials: RK
authors.lastname: Robins
mesh_terms: D002625:Chemistry, Organic; D009711:Nucleotides; D055601:Organic Chemistry Phenomena; D011131:Polyribonucleotides / Q000138:chemical synthesis*; D013698:Templates, Genetic
chemical_list: D009711:Nucleotides; D011131:Polyribonucleotides