Xylose absorption in Down's syndrome.
A standard xylose absorption test was carried out in 14 people with Down's syndrome (DS) and in 14 age-matched mentally deficient controls; a further 30 people with DS were similarly investigated. Mentally deficient people as a group were found to have impaired xylose absorption, the matched DS subjects having a significantly reduced xylose absorption (P less than 0.001) when compared to the mentally deficient controls. Ninety percent of the DS subjects had a xylose excretion below the normal range. At present it is not possible to identify the cause of the malabsorption but it is highly likely that the malabsorption plays a role in a number of the vitamin and mineral deficiencies found in people with DS.
Williams
C A
CA
Quinn
H
H
Wright
E C
EC
Sylvester
P E
PE
Gosling
P J
PJ
Dickerson
J W
JW
D000328:Adult; D004314:Down Syndrome / Q000378:metabolism*; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000378:metabolism*; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D014994:Xylose / Q000378:metabolism*
D014994:Xylose