[Study of the metabolism of cerebral noradrenaline in depressed patients by the assay of plasma dihydroxyphenylethylene glycol].
Dihydroxy-phenyl-ethylene-glycol (DOPEG or DHPG), a deaminated catabolite of noradrenaline formed after presynaptic re-uptake, is a good marker of metabolic activity in noradrenergic pathways. Plasma levels of free, conjugated and total DOPEG were measured by a radioenzymatic method in 45 patients with major depression selected according to the DSM 3 criteria and in 45 matched controls. A significant decrease in man DOPEG levels was observed in all depressive patients. A dexamethasone suppression test performed in these patients showed no difference in DOPEG levels between responders and non-responders, thus failing to support the hypothesis that subjects with low noradrenergic drive escape suppression. There was no correlation between plasma DOPEG levels and urinary excretion of methoxy-hydroxy-phenylglycol (MOPEG), another marker of noradrenaline metabolic activity. Thirty-one patients were treated with a specific monoaminergic antidepressant: maprotiline or indalpine; contrary to urinary MOPEG levels, plasma DOPEG levels had no predictive value concerning the response to this category of antidepressants. The various possible reasons for the fall in DOPEG observed in depressive patients are discussed.
Loo
H
H
Scatton
B
B
Poirier
M F
MF
Benkelfat
C
C
Dennis
T
T
Vanelle
J M
JM
Garreau
M
M
Sechter
D
D
D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism*; D003866:Depressive Disorder / Q000097:blood*; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D006018:Glycols / Q000097:blood*; D006801:Humans; D008297:Male; D008376:Maprotiline / Q000627:therapeutic use; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives / Q000097:blood* / Q000652:urine; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism*; D010880:Piperidines / Q000627:therapeutic use
D000928:Antidepressive Agents; D006018:Glycols; D010880:Piperidines; D008376:Maprotiline; D008734:Methoxyhydroxyphenylglycol; D003907:Dexamethasone; C010117:3,4-dihydroxyphenylglycol; C018181:indalpine; D009638:Norepinephrine
Etude du métabolisme de la noradrénaline cérébrale chez les déprimés par le dosage du dihydroxy-phényl-éthylène-glycol plasmatique.