The response of peripheral blood mononuclear cells of glioma-bearing patients to stimulation with microbial antigen and IL-2: proliferation and IFN-gamma production.
Peripheral blood mononuclear cells (PBMC) of malignant glioma-bearing patients were stimulated in vitro with a glucomannan-protein antigen of Candida albicans (GMP) or Interleukin-2 (IL-2), then assayed for proliferation and production of Interferon gamma. PBMC of healthy, age and sex matched subjects were the controls. PBMC from glioma-bearing patients did not differ, as a whole, from PBMC of healthy donors in IL-2 or GMP-induced proliferation. However, they showed a definitely lesser ability to produce IFN. The results are discussed in the framework of the impairment of immune responses known to affect glioma-bearing patients.
Maleci
A
A
Dipartimento di Scienze Neurologiche, Università di Roma La Sapienza, Italy.
Ausiello
C
C
Gagliardi
F M
FM
Guidetti
B
B
Cassone
A
A
D000946:Antigens, Fungal / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology*; D002455:Cell Division; D005910:Glioma / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000276:immunology / Q000494:pharmacology*; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism / Q000502:physiology
D000946:Antigens, Fungal; D007376:Interleukin-2; D007371:Interferon-gamma