Seminal pepsinogen C is not identical with, but is very similar to gastric pepsinogen C.
Human seminal pepsinogen C has been purified and compared with gastric pepsinogen C. The two zymogens cannot be distinguished by amino acid compositions and sequences of the first 28 N-terminal amino acid residues are identical. Apparent immunological identity is observed with polyclonal antisera. Monoclonal antibodies toward seminal pepsinogen C have been produced. One is able to recognize a non-carbohydrate antigenic determinant only present in seminal pepsinogen C.
Szecsi
P B
PB
Department of Clinical Chemistry, Hvidovre Hospital, Denmark.
Koch
C
C
Foltmann
B
B
D000596:Amino Acids / Q000032:analysis; D000911:Antibodies, Monoclonal; D002848:Chromatography, DEAE-Cellulose; D002850:Chromatography, Gel; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology*; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D010435:Pepsinogens / Q000276:immunology / Q000302:isolation & purification*; D012661:Semen / Q000201:enzymology*
D000596:Amino Acids; D000911:Antibodies, Monoclonal; D010435:Pepsinogens