The use of warfarin in pregnancy complicated by circulating lupus anticoagulant; a technique for monitoring.
A case is described in which a pregnancy, preceded by two mid-trimester fetal losses, was complicated by deep-vein thrombosis due to the presence of circulating lupus anticoagulant. Warfarin was used as anticoagulant therapy concurrently with high-dose prednisolone. It is suggested that warfarin may have advantages over heparin in managing pregnancies in women with circulating lupus anticoagulant. A technique is described which allowed the monitoring of levels of lupus anticoagulant in the circulation while warfarin is being administered.h3.
Campbell
J M
JM
Department of Obstetrics & Gynaecology, Huddersfield Royal Infirmary, Leeds, U.K.
Tate
G
G
Scott
J S
JS
D000328:Adult; D001778:Blood Coagulation Disorders / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D001779:Blood Coagulation Factors / Q000276:immunology* / Q000378:metabolism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D008991:Monitoring, Physiologic; D011239:Prednisolone / Q000627:therapeutic use; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000188:drug therapy*; D013924:Thrombophlebitis / Q000209:etiology; D014859:Warfarin / Q000627:therapeutic use*
D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor; D014859:Warfarin; D011239:Prednisolone