Fecapentaene causes sister-chromatid exchanges in human lymphocytes.
Fecapentaenes are potent mutagenic compounds found in human feces that are considered as potential colon carcinogens. It is demonstrated that a synthetic racemic all-trans fecapentaene-12 (fec-12) causes a strong dose-dependent increase in the frequency of sister-chromatid exchanges (SCE) in human lymphocytes exposed at different stages of the cell cycle. The SCE-inducing capacity is consistent with published results on the DNA-damaging activity of fec-12 such as formation of DNA single-strand breaks and interstrand cross-links.
Bauchinger
M
M
Institut für Strahlenbiologie, GSF, Munich, F.R.G.
Bartha
R
R
Schmid
E
E
Pfaendler
H R
HR
D002453:Cell Cycle; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D011090:Polyenes / Q000008:administration & dosage / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D011090:Polyenes; C037357:1-(1-glycero)dodeca-1,3,5,7,9-pentaene