Psychosis, lithium-induced antipsychotic response, and seasonality.
Lithium alone has previously been shown to effect antipsychotic response in approximately one-quarter of mood incongruent psychoses. Such lithium-responsive psychoses and/or the antipsychotic effects of lithium appear to be seasonal, with maximal response rates occurring in the 3-month periods surrounding January and July peaks. Within patients, retrials of lithium in formerly lithium-responsive psychotic patients demonstrate a trend toward greater continued antipsychotic effects of lithium during the periods surrounding January and July (80% response rates) vs. the remaining 6 months of the year (33% response rates).
Garver
D L
DL
University of Cincinnati College of Medicine, OH 45267-0559.
Hutchinson
L J
LJ
D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D016651:Lithium Carbonate; D011379:Prognosis; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000523:psychology; D011897:Random Allocation; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D012621:Seasons
D016651:Lithium Carbonate; D008094:Lithium