[Study of distraction osteogenesis in an animal body submitted to anticancer chemotherapy].
The authors studied distraction osteogenesis in an animal subjected to prolonged anti-mitotic chemotherapy (Methotrexate and Doxorubicin). This chemotherapy decreased osteogenesis (essentially at the expense of external regeneration) though without inhibiting it totally. Distraction bone consolidation is thus possible in the animal, permitting reconstruction of limb segments by mobilization of an axial fragment in accordance with the Ilizarov technique.
Prevot
J
J
Service de Chirurgie Infantile A, Hôpital d'Enfants, Vandoeuvre-les-Nancy.
Poncelet
T
T
Lemelle
J L
JL
Lascombes
P
P
Blanquart
D
D
Membre
H
H
Olive
D
D
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D001852:Bone Lengthening; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology; D008727:Methotrexate / Q000008:administration & dosage / Q000494:pharmacology; D009984:Orthopedic Fixation Devices; D010012:Osteogenesis / Q000187:drug effects*; D011817:Rabbits; D013997:Time Factors
D000970:Antineoplastic Agents; D004317:Doxorubicin; D008727:Methotrexate
Etude de l'ostéogénèse en distraction sur un organisme animal soumis à une chimiothérapie anti-cancéreuse.