Intrathecal synthesis of specific IgG in syphilitic patients with human immunodeficiency virus 1 infection.
Intrathecal synthesis of immunoglobulin G (IgG) specific to Treponema pallidum, ssp. pallidum, or to the human immunodeficiency virus 1 (HIV-1) was investigated in patients with contemporary treponemal and HIV-1 infections. Using a T. pallidum and an HIV-1 IgG enzyme-linked immunosorbent assay, specific antibody units per milligram of total IgG were estimated in serum and cerebrospinal fluid (CSF) of 13 patients infected with both agents. Synthesis of anti-treponemal IgG in the central nervous system (CNS) was shown in three and of anti-HIV-1 IgG in nine patients with neurological disorders. It is concluded that a differentiation of local IgG immune response in the CNS to one or both infectious agents is possible.
Müller
F
F
Hygienisches Institut, Hamburg, Federal Republic of Germany.
Moskophidis
M
M
Schmitz
H
H
D000386:AIDS-Related Complex / Q000150:complications / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid / Q000150:complications / Q000276:immunology*; D000914:Antibodies, Viral / Q000134:cerebrospinal fluid*; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis / Q000134:cerebrospinal fluid*; D013587:Syphilis / Q000134:cerebrospinal fluid / Q000150:complications / Q000276:immunology*
D000914:Antibodies, Viral; D015483:HIV Antibodies; D007074:Immunoglobulin G