Sézary's syndrome: a case with blood T-lymphocytes of helper phenotype, elevated IgE levels and circulating immune complexes.
A patient with Sézary's syndrome is described. Surface marker analysis of her peripheral blood lymphocytes exhibit a phenotype characteristic of mature helper T cells (OKT3+, OKT4+, OKT8-, OKT6-). Serological studies revealed a polyclonal hyperimmunoglobulinemia with large amounts of IgE and IgA and circulating immune complexes that activate the complementary system via alternative pathway. The patient's cells showed a helper activity on normal B cell differentiation after a 7-day co-culture with pokeweed mitogen. The relevance of this helper phenotype and the function on in vivo polyclonal B cell activation is discussed.
Spinozzi
F
F
Cernetti
C
C
Gerli
R
R
Bertotto
A
A
Rambotti
P
P
D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis*; D001402:B-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007959:Lymphocyte Culture Test, Mixed; D012751:Sezary Syndrome / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000936:Antigen-Antibody Complex; D007073:Immunoglobulin E