[Antibiotic levels in blood serum and mandibular bone in rats with and without phenylbutazone administration].
Antibiotics' level was estimated in mandible and serum of wistar albino rats with and without co-administration of phenylbutazone, 5 groups of animals were used. The animals of group A were injected with 1 g/kg ampicillin and these of group B 1g/kg ampicillin and 100 mg/kg phenylbutazone im. To the animals of group C cephapirin was given 1 g/kg and these of group D 1g/kg cephapirin with 100 mg/kg phenylbutazone. The animals of group E were injected only with phenylbutazone. All the drugs, were given at a single dose. The level of antibiotics was estimated in serum and in mandible with the method of minimal inhibitory concentration (MIC). An increase of the levels of antibiotics (ampicillin, cephapirin) was observed in those groups (B, D) to the animals of which phenylbutazone was given (together with antibiotics), compared with the groups (A, C) which had received antibiotics alone.
Teseromati
C
C
Papadopoulos
J
J
Storaiti
E
E
Tralil
H
H
D000667:Ampicillin / Q000008:administration & dosage* / Q000032:analysis / Q000097:blood; D000818:Animals; D002514:Cephapirin / Q000008:administration & dosage* / Q000032:analysis / Q000097:blood; D004338:Drug Combinations; D008334:Mandible / Q000737:chemistry*; D010653:Phenylbutazone / Q000008:administration & dosage* / Q000032:analysis / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
D004338:Drug Combinations; D000667:Ampicillin; D002514:Cephapirin; D010653:Phenylbutazone
Epipeda antibiotikon ston oro tou aimatos kai sto ostoun tes kato gnathou epimyon me kai choris chroegese phainylboutazones.