Therapeutic efficacy of teicoplanin in experimental enterococcal endocarditis.
The antimicrobial activities of teicoplanin and ampicillin, alone and in combination with gentamicin, were compared in experimental Streptococcus faecalis endocarditis. Bacterial titers in vegetations of rabbits treated with teicoplanin were significantly lower than those of untreated controls (P less than 0.01) and were equivalent to titers in ampicillin-treated animals. Gentamicin increased the activities of both drugs to a comparable degree.
Sullam
P M
PM
Täuber
M G
MG
Hackbarth
C J
CJ
Sande
M A
MA
D000667:Ampicillin / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D013293:Enterococcus faecalis / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology; D006020:Glycopeptides / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D013290:Streptococcal Infections / Q000188:drug therapy*; D017334:Teicoplanin; D013997:Time Factors
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D006020:Glycopeptides; D017334:Teicoplanin; D000667:Ampicillin