Induction of creatine kinase in immature rat uteri by zearalenone, an estrogenic mycotoxin.
Intraperitoneal administration of alpha-zearalenone (ZEN) to female immature rats induced synthesis of a uterine protein which has been identified as creatine kinase. The induced enzyme was purified to homogeneity by chromatography on DEAE Sephacel and Hydroxyapatite Ultrogel. Guinea pig antiserum against estrogen-induced uterine, rat uterine creatine kinase crossreacted with the ZEN-induced enzyme, indicating that ZEN exhibits an early estrogenic response in a manner analogous to natural estrogens.
Seeger
J I
JI
Kumar
S A
SA
D000818:Animals; D003402:Creatine Kinase / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D008970:Molecular Weight; D012118:Resorcinols / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects / Q000201:enzymology*; D015025:Zearalenone / Q000494:pharmacology*
D004967:Estrogens; D012118:Resorcinols; D015025:Zearalenone; D003402:Creatine Kinase