Genetic relationships of Mlsa among polymorphic loci on distal mouse chromosome 1.
The segregation of Mlsa with respect to genes localized distally on mouse chromosome 1 was examined in two sets of recombinant inbred (RI) strains. In order to localize Mlsa, a linkage map based on analysis of both interspecific backcross mice and multiple sets of RI strains was utilized: (centromere) - Ren-1,2 - 10 centimorgans (cM) - At-3 - 8cM-Apo-A2/Ly-17 - 2cM - Spna-1 - 4cM - Akp-1 - (telomere). The Mlsa allele was mapped to a region that extended just centromeric of Ly-17 (one crossover in 40 RI strains) to just telomeric of Spna-1 (no crossover in 40 RI strains). The identification of multiple polymorphic loci in the region of Mlsa should allow precise gene localization and assist in efforts to clone this gene.
Seldin
M F
MF
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
Abe
R
R
Steinberg
A D
AD
Hodes
R J
RJ
Morse
H C
HC
D000483:Alleles; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D015139:Blotting, Southern; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D008040:Genetic Linkage; D051379:Mice; D016747:Minor Lymphocyte Stimulatory Antigens; D011110:Polymorphism, Genetic
D000954:Antigens, Surface; D016747:Minor Lymphocyte Stimulatory Antigens