Inversion of chromosome 5 long arm in region of cell growth gene cluster in hematologic disorders.
Inversions of the long (q) arm of chromosome #5 are reported in five cases with hematologic disorders. Inversion of 5q with breakpoints in bands 5q13 and 5q33 was found in two cases with lymphoid malignancy and in two cases of myeloid hematologic malignancy. Because an inversion of 5q with breakpoints in 5q22 and 5q33 was also found in a case with myeloproliferative syndrome, the common denominator in these five cases was band 5q33. An extraordinary cluster of genes affecting cell growth and differentiation is present on 5q and may be altered by the chromosome rearrangement of 5q in hematologic disorders.
Morgan
R
R
Cancer Center, Southwest Biomedical Research Institute, Scottsdale, AZ 85251.
Walter
T A
TA
Decker
H J
HJ
Hecht
F
F
Sandberg
A A
AA
D000328:Adult; D002455:Cell Division; D002648:Child; D002675:Child, Preschool; D002871:Chromosome Banding; D002873:Chromosome Fragility; D007446:Chromosome Inversion; D002895:Chromosomes, Human, Pair 5; D005260:Female; D005819:Genetic Markers; D006402:Hematologic Diseases / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D005810:Multigene Family
D005819:Genetic Markers