title: Surgical treatment for osteosarcoma.
abstract: Fifty-three patients who had a high-grade osteosarcoma had either a limb-salvage resection or an amputation. They all received adjuvant therapy that consisted of administration of Adriamycin (doxorubicin) and whole-lung irradiation. At the time of follow-up, the surgical margin was assessed by examination of the surgical specimen. Each patient was followed for at least three years or until death. The data suggested that a wide surgical margin is adequate to control a primary osteosarcoma. When a wide surgical margin can be used and a functional limb can be salvaged, an amputation probably is not required.
authors.affiliation: Department of Orthopaedics, University of Florida, Gainesville 32610.
authors.forename: D S
authors.initials: DS
authors.lastname: Springfield
authors.forename: R
authors.initials: R
authors.lastname: Schmidt
authors.forename: J
authors.initials: J
authors.lastname: Graham-Pole
authors.forename: R B
authors.initials: RB
authors.lastname: Marcus
authors.forename: S S
authors.initials: SS
authors.lastname: Spanier
authors.forename: W F
authors.initials: WF
authors.lastname: Enneking
mesh_terms: D000293:Adolescent; D000328:Adult; D000671:Amputation, Surgical; D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D001932:Brain Neoplasms / Q000556:secondary; D002648:Child; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012516:Osteosarcoma / Q000473:pathology / Q000556:secondary / Q000601:surgery*
chemical_list: D004317:Doxorubicin