title: Massive macroglossia, amyloidosis and myeloma.
abstract: A 74 year old man with light-chain myeloma developed amyloidosis with macroglossia after 10 years of therapy with alkylating agents. Over a 2-year period his tongue enlarged to persistently protrude from his mouth, inhibit his speech, interfere with normal swallowing and eventually threaten his airway. As a life-saving procedure the tumorous anterior two-thirds of the tongue was resected, with excellent primary healing. Within two weeks the patient's speech became comprehensible and his ability to eat returned to normal. Although rare in amyloidosis, massive macroglossia may occur and surgical correction is easily achieved.
authors.affiliation: Department of Haematology, University of Cape Town, South Africa.
authors.forename: P
authors.initials: P
authors.lastname: Jacobs
authors.forename: S
authors.initials: S
authors.lastname: Sellars
authors.forename: H S
authors.initials: HS
authors.lastname: King
mesh_terms: D000686:Amyloidosis / Q000150:complications*; D000818:Animals; D002642:Chick Embryo; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis; D008260:Macroglossia / Q000209:etiology*; D008297:Male; D009101:Multiple Myeloma / Q000150:complications*; D009194:Myeloma Proteins / Q000032:analysis
chemical_list: D007147:Immunoglobulin Light Chains; D009194:Myeloma Proteins