title: Definition of response and remission in children over one year of age with advanced neuroblastoma: proposition for a scoring system.
abstract: A two-step evaluation system is proposed to analyze the results of therapy for stage IV neuroblastoma in children over 1 year of age. Since most protocols consist of first-line chemotherapy followed by surgery and often high-dose chemotherapy with bone marrow rescue, "response" should assess the effect of chemotherapy alone and "remission" indicate the status after an attempt to remove the primary tumor. A scoring system is proposed for both steps. The comparability of different studies depends on the use of such common criteria to define patient groups and treatment results.
authors.affiliation: Centre Leon Berard, Lyon, France.
authors.forename: T
authors.initials: T
authors.lastname: Philip
authors.forename: L
authors.initials: L
authors.lastname: Helson
authors.forename: J L
authors.initials: JL
authors.lastname: Bernard
authors.forename: J M
authors.initials: JM
authors.lastname: Zucker
authors.forename: B
authors.initials: B
authors.lastname: Kremens
authors.forename: M
authors.initials: M
authors.lastname: Favrot
authors.forename: O
authors.initials: O
authors.lastname: Hartmann
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D012074:Remission Induction