[Evaluation of erythrocyte survival by the determination of glycosylated hemoglobin. Clinical value].
In normoglycaemic subjects the haemoglobin glycosylation rate primarily depends on duration of erythrocyte life. Measurements of glycosylated haemoglobin therefore can be used to evaluate erythrocyte life. Indeed, glycosylated haemoglobin is significantly reduced (p less than 0.001) in patients with autoimmune haemolytic anaemia or Minkowski-Chauffard syndrome as compared with patients with non-haemolytic anaemia. In addition, there is a strong correlation (r = 0.92) in non-diabetic subjects between the level of glycosylated haemoglobin and the percentage of daily haemolysis, as determined by a method using 51 Cr-labelled antologous red cells.
Rigal
D
D
Monestier
M
M
Baboin-Jaubert
M
M
Chabaud-Sassoulas
D
D
Marseglia
G L
GL
Ville
D
D
Meyer
F
F
Jouvenceaux
A
A
D000740:Anemia / Q000097:blood*; D000743:Anemia, Hemolytic / Q000097:blood*; D002860:Chromium Radioisotopes; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000000981:diagnostic imaging; D006442:Glycated Hemoglobin / Q000032:analysis*; D006461:Hemolysis; D006801:Humans; D011877:Radionuclide Imaging
D002860:Chromium Radioisotopes; D006442:Glycated Hemoglobin
Appréciation de la durée de vie des globules rouges par le dosage de l'hémoglobine glycosylée. Intérêt clinique.