[Effect high-altitude conditions on the antitumor activity of cyclophosphane and its action on lymphoid tissue cells].
High-altitude hypoxia inhibits the Walker carcinosarcoma growth in rats and enhances the efficacy of antitumour treatment with cyclophosphane. Under mountain conditions the cyclophosphane toxicity effect on the lymphoid tissue decreased. As a response to cyclophosphane administration the depletion of the lymphocyte amount in the peripheral blood and cell populations in the thymus, spleen, lymph nodes of animals was less expressed at high altitude (3200 m) than at low one (760 m). In clinical research it was shown that high-altitude hypoxia may be used as a therapeutic factor in the management of cytostatic lymphocytopenias in cancer patients.
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D000531:Altitude; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D003520:Cyclophosphamide / Q000627:therapeutic use* / Q000633:toxicity; D004317:Doxorubicin / Q000008:administration & dosage; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007707:Kyrgyzstan; D008214:Lymphocytes / Q000187:drug effects*; D008231:Lymphopenia / Q000628:therapy; D009368:Neoplasm Transplantation; D051381:Rats; D013997:Time Factors; D014747:Vinblastine / Q000008:administration & dosage
D014747:Vinblastine; D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil
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