A candidate gene family for the mouse t complex responder (Tcr) locus responsible for haploid effects on sperm function.
The mouse t complex responder (Tcr) locus plays a central haploid-specific role in the transmission ratio distortion phenotype expressed during germ cell differentiation in t-carrying males. The accumulated data map Tcr to a region of less than 500 kb. Over 400 kb of this region has been cloned and consists entirely of sequences associated with a clustered family of large cross-hybridizing elements of 30 kb to 70 kb in size. We have characterized a gene family within this region that is expressed uniquely in male germ cells with a complex pattern of RNA processing. Antibodies produced against a product of the putative open reading frame recognize a testes-specific polypeptide. Genetic data support the hypothesis that this polypeptide(s) functions to effect the Tcr phenotype.
Schimenti
J
J
Department of Molecular Biology, Princeton University, New Jersey 08544.
Cebra-Thomas
J A
JA
Decker
C L
CL
Islam
S D
SD
Pilder
S H
SH
Silver
L M
LM
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D006238:Haploidy; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D010641:Phenotype; D013094:Spermatozoa / Q000502:physiology* / Q000648:ultrastructure