Spinal cord transections in fetal rats. Open intrauterine surgery with low mortality.
Open myelotomies were performed in rat fetuses in stages E15-E19 with a microsurgical technique. To prevent oligohydramnios, considered to be one of the main causes of death associated with fetal surgery, amniotic fluid loss was reduced as much as possible. With this technique a reduction of the mortality rate to 38% was reached in 75 consecutive fetuses.
De Beer
F C
FC
Department of Neurosurgery, Leiden University Hospital, The Netherlands.
Thomeer
R T
RT
Lakke
E
E
De Vries
J
J
Voogd
J
J
D000818:Animals; D002818:Cordotomy / Q000379:methods* / Q000401:mortality; D005260:Female; D005333:Fetus / Q000601:surgery*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000196:embryology* / Q000601:surgery