title: Pharmacological characterization of the physostigmine stimulus in rats.
abstract: Rats were trained to discriminate 0.10 mg/kg SC physostigmine from saline in a two-lever food-reinforced task. There was generalization to the acetylcholine esterase inhibitor THA as well as to the muscarinic receptor agonists arecoline, oxotremorine and RS 86, but not to neostigmine or nicotine. The physostigmine cue was blocked by SC scopolamine hydrobromide and by ICV pirenzepine, but not by scopolamine methylbromide or by mecamylamine. These antagonism studies suggest that the discriminative cue elicited by physostigmine might be mainly mediated by central M1 receptors.
authors.affiliation: Sanofi Recherche, rue du Professeur J.-Blayac, Montpellier, France.
authors.forename: M
authors.initials: M
authors.lastname: Jung
authors.forename: A
authors.initials: A
authors.lastname: Perio
authors.forename: P
authors.initials: P
authors.lastname: Worms
authors.forename: P
authors.initials: P
authors.lastname: Soubrie
mesh_terms: D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004192:Discrimination, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005795:Generalization, Stimulus / Q000187:drug effects; D008297:Male; D009538:Nicotine / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D012055:Reinforcement Schedule
chemical_list: D002800:Cholinesterase Inhibitors; D010277:Parasympathomimetics; D009538:Nicotine; D010830:Physostigmine