Positron emission tomography in movement disorders.
Positron emission tomography provides a method for the quantitation of regional function within the living human brain. Studies of cerebral metabolism and blood flow in patients with Huntington's disease, Parkinson's disease and focal dystonia have revealed functional abnormalities within substructures of the basal ganglia. Recent developments permit assessment of both pre-synaptic and post-synaptic function in dopaminergic pathways. These techniques are now being applied to studies of movement disorders in human subjects.
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D001921:Brain / Q000378:metabolism; D002560:Cerebrovascular Circulation; D003342:Corpus Striatum / Q000378:metabolism; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004421:Dystonia / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism; D007980:Levodopa / Q000627:therapeutic use; D009069:Movement Disorders / Q000000981:diagnostic imaging*; D010101:Oxygen Consumption; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology; D013569:Synapses / Q000378:metabolism; D014055:Tomography, Emission-Computed
C029112:5-fluorodopa; D007980:Levodopa; D004295:Dihydroxyphenylalanine; D005947:Glucose; D004298:Dopamine