Nonamyloidotic monoclonal immunoglobulin deposits lack amyloid P component.
Deposits in tissues from 13 patients with amyloid, 8 with monoclonal light chain or light and heavy chain deposition disease, and 2 with both amyloid and nonamyloidotic light chain deposits of the same isotype were examined in parallel for the presence of amyloid P component by immunofluorescence and/or immunoperoxidase methods. Amyloid P component was detected in the amyloid but not the nonamyloid deposits, even in the 2 individuals in whom both types of deposits were present, indicating a specific relationship between the amyloid P component and the amyloid fibrils.
Gallo
G
G
Department of Pathology, New York University School of Medicine, New York.
Picken
M
M
Frangione
B
B
Buxbaum
J
J
D000686:Amyloidosis / Q000276:immunology*; D003106:Colon / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006362:Heavy Chain Disease / Q000276:immunology*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007124:Immunoenzyme Techniques; D007137:Immunoglobulin alpha-Chains / Q000032:analysis; D007142:Immunoglobulin gamma-Chains / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D007668:Kidney / Q000276:immunology; D000683:Serum Amyloid P-Component / Q000032:analysis*
D007137:Immunoglobulin alpha-Chains; D007142:Immunoglobulin gamma-Chains; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D000683:Serum Amyloid P-Component