title: Biosynthesis of anthracyclinones.
abstract: Recent biosynthetic studies confirmed that anthraquinones are involved as intermediates in the pathway to anthracyclines. The present knowledge in this field has been reviewed. Furthermore, a new generalized order of biosynthetic intermediates from the hypothetical polyketide to aklavinone and related anthracyclinones has been proposed involving tricyclic precursors and 7-hydroxy-naphthacenequinones, which also have been found in mutants of anthracycline-producing strains.
authors.affiliation: Akademie der Wissenschaften der DDR, Zentralinstitut für Mikrobiologie und experimentelle Therapie, Jena.
authors.forename: K
authors.initials: K
authors.lastname: Eckardt
authors.forename: C
authors.initials: C
authors.lastname: Wagner
mesh_terms: D000880:Anthraquinones / Q000378:metabolism; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D009279:Naphthacenes / Q000096:biosynthesis / Q000378:metabolism; D013302:Streptomyces / Q000378:metabolism
chemical_list: D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; C027832:aklavinone