title: Occurrence of transient cavitation in pulsed sawtooth ultrasonic fields.
abstract: Thus far, studies conducted to assess the safety of diagnostic ultrasound have employed sinusoidal sound fields. To evaluate the influence of nonlinearly distorted acoustic fields, this article compares the responses of microbubbles of variable size, exposed to (1) a sinusoidal pulse and (2) a sawtooth pulse. The nonlinear oscillations of a spherical bubble in a viscous compressible liquid stimulated into motion by an ultrasonic pulse are predicted, using a theoretical model for bubble dynamics. The maximum gas pressures inside the bubble when it collapses under the influence of a sinusoid or a sawtooth are deduced. Experimental work on Drosophila larvae exposed to sinusoidal and to sawtooth fields is consistent with the theoretical analysis.
authors.affiliation: Department of Electrical Engineering, University of Rochester, New York 14627.
authors.forename: E J
authors.initials: EJ
authors.lastname: Aymé
authors.forename: E L
authors.initials: EL
authors.lastname: Carstensen
mesh_terms: D000162:Acoustics; D000818:Animals; D004331:Drosophila melanogaster; D005740:Gases; D007814:Larva; D008962:Models, Theoretical; D011312:Pressure; D014463:Ultrasonography / Q000009:adverse effects*
chemical_list: D005740:Gases