In vivo modulation of murine collagen induced arthritis.
The effects of in vivo modulation of murine collagen induced arthritis with monoclonal anti-CD4 antibodies, monoclonal anti-Ia antibodies, and gamma interferon are reviewed. We detail the mechanism of action of monoclonal anti-CD4 antibody on humoral and cell mediated immune responses and discuss the implications for designing therapeutic strategies. To further explore the induction of collagen induced arthritis, a syngeneic cell transfer system using collagen primed T lymphocytes is described. This cell transfer system provides an opportunity to study the role of CD4 positive T lymphocytes in arthritis induction during a short, defined time period.
Ranges
G E
GE
Department of Medicine, University of Vermont College of Medicine, Burlington 05405.
Fortin
S
S
Barger
M T
MT
Sriram
S
S
Cooper
S M
SM
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000276:immunology* / Q000628:therapy; D003094:Collagen / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007167:Immunotherapy; D007371:Interferon-gamma / Q000276:immunology; D051379:Mice
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000949:Histocompatibility Antigens Class II; D007371:Interferon-gamma; D003094:Collagen