Assessment of the pathogenicity of bacterial species isolated from acute dentoalveolar abscesses.
The pathogenicity of 20 strains belonging to nine bacterial species isolated from acute dentoalveolar abscesses was assessed individually and in two species combinations by subcutaneous inoculation of mice. Infections were produced by all the bacteria although variations were seen both in the type of lesion produced and the subsequent recovery of viable bacteria. Anaerobic gram-negative bacilli were recovered more often (p less than 0.05) at high concentrations (10(6)-10(9) cfu/ml) and produced a localised abscess with peripheral necrosis more frequently (p less than 0.001) than either Streptococcus milleri or anaerobic gram-positive cocci. Lesions induced by a combination of bacteria comprising anaerobic gram-negative bacillus and any other species yielded both strains at high concentration more often (p less than 0.001) than a combination comprising anaerobic gram-positive cocci and S. milleri. It is concluded that anaerobic gram-negative bacilli are major pathogens in acute dentoalveolar abscesses.
Lewis
M A
MA
Department of Oral Medicine and Pathology, Glasgow Dental Hospital and School.
MacFarlane
T W
TW
McGowan
D A
DA
MacDonald
D G
DG
D000208:Acute Disease; D000818:Animals; D001419:Bacteria / Q000472:pathogenicity*; D001439:Bacteroides / Q000472:pathogenicity; D005673:Fusobacterium / Q000472:pathogenicity; D006801:Humans; D008297:Male; D051379:Mice; D010460:Peptococcus / Q000472:pathogenicity; D010482:Periapical Abscess / Q000382:microbiology*; D013291:Streptococcus / Q000472:pathogenicity