[Cholinergic effects of nootropics].
With respect to the enhancing effect of nootropics on learning and memory, the influence of some of these drugs on the high affinity choline uptake has been investigated. Meclofenoxate competes with choline uptake in vitro because of its similar side chain; other nootropics are without in vitro effects. A single dose of pramiracetam enhances the choline uptake in cortex and hippocampus. Application of meclofenoxate decreases the uptake of choline. Other nootropics lack acute effects. Possible increases of uptake after repeated dosage disappear within 24 h.
Funk
K F
KF
Institut für Pharmakologie und Toxikologie, Medizinische Akademie Carl Gustav Carus, Dresden, DDR.
Schmidt
J
J
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002491:Central Nervous System Agents / Q000494:pharmacology*; D002794:Choline / Q000378:metabolism*; D005260:Female; D007858:Learning / Q000187:drug effects*; D002504:Meclofenoxate / Q000494:pharmacology; D008568:Memory / Q000187:drug effects*; D010889:Piracetam / Q000494:pharmacology; D011746:Pyrithioxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D002491:Central Nervous System Agents; D011746:Pyrithioxin; D002504:Meclofenoxate; D002794:Choline; D010889:Piracetam
Zur cholinergen Wirkung von Nootropika.