Antiinflammatory effect of a lipoxygenase inhibitor (FLM 5011) in severe active myocarditis.
FLM 5011 belongs to a group of chemical compounds with isolated lipoxygenase products in human polymorphonuclear leukocytes and alveolar macrophages. FLM 5011 has been shown to be protective against arachidonic acid-induced bronchoconstriction in vitro and in vivo. No severe side-effects were found in extensive tests on acute and subchronic toxicity in animals. In preliminary investigations on patients with severe active myocarditis impressive clinical and histological improvements after administration of FLM 5011 have been obtained, suggesting an antiinflammatory effect of the substance. A follow-up of more than 13 months compared with conventional immunosuppressive therapy indicates potential therapeutic value of this compound on the inflamed myocardium.
Geissler
W
W
Klinik für Innere Medizin, Humboldt-Universität, Berlin.
Förster
A
A
Schewe
T
T
Rapoport
S M
SM
Slapke
J
J
Meyer
R
R
Romaniuk
P
P
Reisinger
I
I
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001379:Azathioprine / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004008:Diclofenac / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007165:Immunosuppression Therapy; D007167:Immunotherapy; D007850:Lauric Acids; D008084:Lipoxygenase / Q000627:therapeutic use; D016859:Lipoxygenase Inhibitors; D008297:Male; D009205:Myocarditis / Q000188:drug therapy* / Q000628:therapy; D010091:Oximes; D011239:Prednisolone / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007850:Lauric Acids; D016859:Lipoxygenase Inhibitors; D010091:Oximes; C059535:FLM 5011; D004008:Diclofenac; D011239:Prednisolone; D008084:Lipoxygenase; D001379:Azathioprine