title: Fleroxacin in single dose oral therapy of uncomplicated lower urinary tract infection.
abstract: A randomized comparative study was performed in twenty women with acute uncomplicated lower urinary tract infection (UTI). They received a single oral dose of either fleroxacin 600 mg or amoxycillin 3 g. Pathogens were Escherichia coli (17), Proteus mirabilis (2) and Staphylococcus aureus (1). A complete clinical and microbiological cure was observed in all patients of both groups. One patient in the fleroxacin group had gastric irritation. A single oral dose of fleroxacin may be suitable for the treatment of lower UTI even when it is due to organisms resistant to amoxycillin and other traditional oral antimicrobials.
authors.affiliation: First Department of Medicine, General Hospital, Athens, Greece.
authors.forename: J
authors.initials: J
authors.lastname: Kosmidis
authors.forename: P
authors.initials: P
authors.lastname: Gargalianos
authors.forename: G
authors.initials: G
authors.lastname: Adamis
authors.forename: D
authors.initials: D
authors.lastname: Petropoulou
authors.forename: D
authors.initials: D
authors.lastname: Makris
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D016576:Fleroxacin; D006801:Humans; D008875:Middle Aged; D011513:Proteus mirabilis / Q000187:drug effects; D011897:Random Allocation; D013211:Staphylococcus aureus / Q000187:drug effects; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D000658:Amoxicillin; D016576:Fleroxacin