Dopamine receptor antagonists inhibit the natriuretic response to atrial natriuretic factor (ANF).
The diuretic and natriuretic response of anesthetized rats to low doses of semi-purified atrial extracts or synthetic alpha-hANP was completely blocked by intravenous injection of 50 micrograms of haloperidol or chlorpromazine. Sulpiride or metoclopramide at the same doses did not show this effect. We conclude from these results that dopamine receptors, probably of the D1-type, are involved in the natriuretic effect of the atrial peptides.
Marin-Grez
M
M
Briggs
J P
JP
Schubert
G
G
Schnermann
J
J
D000262:Adenylyl Cyclases / Q000502:physiology; D000818:Animals; D009320:Atrial Natriuretic Factor; D004232:Diuretics / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D009124:Muscle Proteins / Q000494:pharmacology*; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*
D004232:Diuretics; D009124:Muscle Proteins; D011954:Receptors, Dopamine; D009320:Atrial Natriuretic Factor; D000262:Adenylyl Cyclases; D006220:Haloperidol; D004298:Dopamine