Pharmacokinetics of gold sodium thiomalate in rabbits.
Male, New Zealand white rabbits (3.5-4.3 kg) received a single 2-mg/kg dose of gold sodium thiomalate (Myochrysine) via intramuscular (N = 4) and intravenous (N = 3) routes. Blood samples were drawn from the marginal ear vein for a period of 5-10 days. The concentration of gold in whole blood was determined using graphite furnace atomic absorption spectrophotometry. The blood concentration-time profiles obtained following both routes of administration were best described by a two-compartment open model with first-order absorption for the intramuscular route. Gold was absorbed rapidly with a mean (harmonic) absorption half-life of 9.0 min, with a peak concentration of 6.0 +/- 1.0 micrograms/ml (N = 4). Blood concentrations declined in a biphasic manner; the mean alpha half-lives were 0.738 and 1.78 hr for the iv and im routes, respectively. The corresponding terminal (beta) half-lives were 54.1 and 63.0 hr. The estimated volume of the central compartment (70 to 93 ml/kg) agreed closely with the rabbit blood volume. The mean (+/- SD) extent of the dose absorbed following intramuscular injection was 68.9 +/- 12.4%.
Melethil
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S
School of Pharmacy and Medicine, University of Missouri, Kansas City 64108-2792.
Schoepp
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D
D000818:Animals; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits
D006052:Gold Sodium Thiomalate