[Effect of combinations of immunomodulators on phagocytosis].
The effect of levamisole, prodigiozan and lithium carbonate combinations on antimicrobial activity of blood neutrophils and peritoneal macrophages was studied on mice. The combinations were used in single doses. An increase in stimulation of phagocytosis with respect to staphylococci was observed after the use of prodigiozan in combination with lithium carbonate. Levamisole and lithium carbonate were antagonistic with respect to macrophagal phagocytosis. No advantage of the combined use of prodigiozan and levamisole to their use alone was shown.
Medvedev
Iu A
IuA
Alekhin
E K
EK
Riabchinskaia
L A
LA
Iarmukhamedova
A G
AG
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004336:Drug Antagonism; D004359:Drug Therapy, Combination; D007978:Levamisole / Q000008:administration & dosage / Q000494:pharmacology; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology; D016651:Lithium Carbonate; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects*; D011354:Prodigiozan / Q000008:administration & dosage / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects
D000276:Adjuvants, Immunologic; D007978:Levamisole; D016651:Lithium Carbonate; D011354:Prodigiozan; D008094:Lithium
Vliianie kombinatiĭ immunomoduliatorov na fagotsitoz.