title: [Clinical study of cefuzonam in the field of obstetrics and gynecology].
abstract: Cefuzonam (CZON, L-105) was used clinically for the treatment of obstetrical and gynecological infections at a dosage of 1 g once or twice daily by intravenous drip infusion. The results obtained are summarized as follows. 1. Clinical effects of CZON were analyzed in 10 patients, including 5 patients with intrapelvic infections, 3 with intrauterine infections, and 1 each with adnexitis and an external genital infection. Excellent responses were observed in 1 patient (11.1%), good responses in 7 (77.8%), poor responses in 1 (11.1%), and one remaining case was unevaluable. The efficacy ratio was 88.9%. 2. Upon the treatment, eradications of causative bacteria were observed in all 4 cases tested. Staphylococcus sp. (2 strains), Staphylococcus epidermidis (1 strain), Klebsiella oxytoca (1 strain) and Pseudomonas putida (1 strain) were all eradicated by the CZON treatment. 3. The safety of the drug was analyzed in the 10 patients and rash occurred in 1 patient as a side effect. 4. One patient showed eosinophilia after the CZON treatment. It appeared that CZON would be useful for the treatment of obstetrical and gynecological infections.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Hiroshima University.
authors.forename: H
authors.initials: H
authors.lastname: Naito
authors.forename: S
authors.initials: S
authors.lastname: Yamanaka
authors.forename: T
authors.initials: T
authors.lastname: Masaoka
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: T
authors.initials: T
authors.lastname: Urabe
authors.forename: A
authors.initials: A
authors.lastname: Fujiwara
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy*; D015296:Ceftizoxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy*; D014591:Uterine Diseases / Q000188:drug therapy*
chemical_list: C049934:cefuzonam; D015296:Ceftizoxime