Tissue distribution metabolism and excretion of 2,2',4,4',5-pentachlorodiphenyl ether in the rat.
The tissue distribution, metabolism and excretion of 14C-2,2',4,4',5-pentachlorodiphenyl ether (PCDE) were studied in the rat. Radioactivity was distributed in all tissues examined, with the highest concentrations being found in the fat followed by the skin, liver, kidney and muscle. Most of the radioactivity found in the tissues was due to unchanged PCDE. Decay of PCDE in the blood was fitted to a four-compartment pharmacokinetic model, and the last compartment had a half-life of 5.8 days. A total of 55% and 1.3% of an orally administered dose was excreted in feces and urine, respectively, in 7 days. More than 64% of the fecal radioactivity was due to unchanged PCDE, while hydroxylated PCDE accounted for 23%.
Komsta
E
E
Bureau of Chemical Hazards, Environmental Health Directorate, Ottawa, Ontario, Canada.
Chu
I
I
Villeneuve
D C
DC
Benoit
F M
FM
Murdoch
D
D
D000818:Animals; D002250:Carbon Radioisotopes; D055598:Chemical Phenomena; D002621:Chemistry; D004785:Environmental Pollutants / Q000032:analysis* / Q000633:toxicity; D004987:Ethers / Q000493:pharmacokinetics / Q000633:toxicity / Q000652:urine; D005243:Feces / Q000032:analysis; D008297:Male; D013058:Mass Spectrometry; D011078:Polychlorinated Biphenyls / Q000493:pharmacokinetics* / Q000633:toxicity / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D004785:Environmental Pollutants; D004987:Ethers; C058905:2,2',4,4',5-pentachlorodiphenyl ether; D011078:Polychlorinated Biphenyls