title: The short arm of chromosome 6 is nonrandomly rearranged in secondary myelodysplastic syndromes.
abstract: Eight patients with a myelodysplastic syndrome showed a structural rearrangement of the short arm of chromosome #6 involving the distal segment 6p22----6pter. In four cases the myelodysplastic disorder appeared after treatment with chemo- and/or radiotherapy. Cytogenetically, the 6p anomaly was consistently associated with abnormalities of chromosome #5 and/or #7 in seven of eight cases. We believe we identified a new site on 6p that is nonrandomly involved in iatrogenically and possibly also environmentally induced malignant hematologic disorders.
authors.affiliation: Center for Human Genetics, University of Leuven, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Mecucci
authors.forename: J L
authors.initials: JL
authors.lastname: Michaux
authors.forename: A
authors.initials: A
authors.lastname: Louwagie
authors.forename: M
authors.initials: M
authors.lastname: Boogaerts
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002896:Chromosomes, Human, Pair 6; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000209:etiology / Q000235:genetics*
chemical_list: D005819:Genetic Markers