Effect of cefotetan in clindamycin-induced enterocolitis in hamsters.
In hamsters the administration of clindamycin provokes a fatal diarrhea and death in 1-2 days. This study was performed in order to assess the possible protective effect of three cephalosporins in clindamycin-induced enterocolitis in these laboratory animals. The efficacy of cefotetan was compared with that of cefoxitin and latamoxef: the hamsters were treated twice daily for 5 days with clindamycin (10 mg/kg) by oral route, and cefotetan, cefoxitin and latamoxef (100 mg/kg) were given subcutaneously. All animals developed "wet-tail syndrome", but cefotetan and latamoxef were able to protect a large percentage of hamsters from death and to prolong the survival time.
Dubini
F
F
Istituto di Microbiologia Medica, Università degli Studi di Milano, Italy.
D000818:Animals; D015313:Cefotetan / Q000627:therapeutic use*; D002440:Cefoxitin / Q000627:therapeutic use; D002981:Clindamycin / Q000633:toxicity*; D006224:Cricetinae; D004760:Enterocolitis / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008647:Mesocricetus
D002981:Clindamycin; D015313:Cefotetan; D002440:Cefoxitin