Age-related reference values for free amino acids in first morning urine specimens.
We determined age-related reference values for urinary free amino acids (in mmol/mol creatinine) in first morning urine specimens from 360 control subjects who were divided into nine age groups: birth to 1 month, 1-6 months, 6-12 months, 1-2 years, 2-4 years, 4-7 years, 7-10 years, 10-13 years, and older than 13 years. Except for taurine and 3-methylhistidine, the concentration of all the amino acids decreased with increasing age. The use of these results to detect aminoacidopathies and tubulopathies is discussed.
Parvy
P R
PR
Laboratoire de Biochimie Médicale B, Hôpital Necker-Enfants Malades, Paris, France.
Bardet
J I
JI
Rabier
D M
DM
Kamoun
P P
PP
D000293:Adolescent; D000367:Age Factors; D000596:Amino Acids / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008762:Methylhistidines / Q000652:urine; D012016:Reference Values; D013654:Taurine / Q000652:urine
D000596:Amino Acids; D008762:Methylhistidines; D013654:Taurine; C028118:3-methylhistidine