Fibronectin receptor of human macrophages recognizes the sequence Arg-Gly-Asp-Ser.
When cultured human monocytes (MO) were spread on fibronectin (Fn)-coated surfaces, C3 receptors on the MO exhibited markedly enhanced capacity to promote phagocytosis. The activation of C3 receptors by Fn was mediated by a receptor that recognizes a sequence, Arg-Gly-Asp-Ser (RGDS), present in the cell-binding domain of Fn. Soluble, RGDS-containing peptides inhibited the activation of C3 receptors caused by surface-bound Fn, and surface-bound, RGDS-containing peptides themselves caused activation of the C3 receptors of attached MO. Although soluble, RGDS-containing peptides bound to Fn receptors, such monovalent ligation was insufficient to activate C3 receptors.
Wright
S D
SD
Meyer
B C
BC
D000595:Amino Acid Sequence; D005353:Fibronectins / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D016177:Macrophage-1 Antigen; D008264:Macrophages / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D009842:Oligopeptides / Q000378:metabolism* / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects; D011951:Receptors, Complement / Q000378:metabolism; D017469:Receptors, Fibronectin; D011971:Receptors, Immunologic / Q000378:metabolism*
D005353:Fibronectins; D016177:Macrophage-1 Antigen; D009842:Oligopeptides; D011951:Receptors, Complement; D017469:Receptors, Fibronectin; D011971:Receptors, Immunologic