title: Effects of enfenamic acid and its zinc salt on wound-healing.
abstract: Dose-matched comparison between zinc-salt of enfenamic acid and the parent compound was carried out in experimentally wounded male albino rats bearing either sutured incision, dead-space or excision wounds. Result showed that enfenamic-acid significantly decreased breaking-strength of incision wounds and this effects was totally reversed by zinc present in enfenamic acid-zinc salt. Both the parent compound and the salt had significant granulation suppressant effect in dead-space wounds. In excision wounds epithelization was enhanced by enfenamic acid only. The wound contraction was not affected by either test compound.
authors.affiliation: Department of Pharmacology, Kasturba Medical College, Manipal.
authors.forename: C M
authors.initials: CM
authors.lastname: Rao
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: D R
authors.initials: DR
authors.lastname: Kulkarni
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*; D015032:Zinc; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
chemical_list: D062367:ortho-Aminobenzoates; C019126:enfenamic acid; D015032:Zinc