Juvenile myoclonic epilepsy (JME) may be linked to the BF and HLA loci on human chromosome 6.
Although certain forms of epilepsy have long been suspected to be inherited, heterogeneity has made it difficult to find the genes responsible for any subtypes. We found that families ascertained through patients with juvenile myoclonic epilepsy show linkage with the BF and HLA loci on human chromosome 6. There is some evidence that the locus may be outside the HLA complex and no evidence as yet of an association with any allele of the HLA complex.
Greenberg
D A
DA
Comprehensive Epilepsy Program, VA Medical Center West Los Angeles 90073.
Delgado-Escueta
A V
AV
Widelitz
H
H
Sparkes
R S
RS
Treiman
L
L
Maldonado
H M
HM
Park
M S
MS
Terasaki
P I
PI
D000293:Adolescent; D000328:Adult; D002648:Child; D002896:Chromosomes, Human, Pair 6; D011415:Complement Factor B / Q000235:genetics*; D004792:Enzyme Precursors / Q000235:genetics*; D004831:Epilepsies, Myoclonic / Q000235:genetics* / Q000276:immunology; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers / Q000032:analysis; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree
D004792:Enzyme Precursors; D005819:Genetic Markers; D006680:HLA Antigens; D011415:Complement Factor B