title: [Biological activity of surfagon--a synthetic luliberin agonist].
abstract: The biological activity of surfagon (D-Ala6-desGly10-Pro9-ethylamide), a synthetic LH-RH agonist, is dozens of times higher than that of LH-RH in the test of rat hypophyseal stimulation of gonadotropin secretion in vivo and in vitro and in the ovulation induction test. A dose of surfagon required for the stimulation of LH secretion was considerably lower than that for the stimulation of FSH secretion. It may permit the use of surfagon in clinical practice for selective stimulation of secretion either of LH or total gonadotropins--LH and FSH.
authors.forename: O G
authors.initials: OG
authors.lastname: Krivosheev
authors.forename: N A
authors.initials: NA
authors.lastname: Nabatchikova
authors.forename: G I
authors.initials: GI
authors.lastname: Pozdniakova
authors.forename: E A
authors.initials: EA
authors.lastname: Siutkin
authors.forename: V A
authors.initials: VA
authors.lastname: Vinogradov
mesh_terms: D000818:Animals; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism; D008297:Male; D010060:Ovulation / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D007987:Gonadotropin-Releasing Hormone; C010661:surfagon; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
vernacular_title: Biologicheskaia aktivnost' surfagona--sinteticheskogo agonista liuliberina.