Do leukemia patients with chromosome 16 inversion--inv(16)(p13q22)--have a rare fragile site at 16q22?
Chromosomes were examined in the peripheral blood cells from three cases of acute myelomonocytic leukemia (AMMoL) with inv(16)(p13q22) in order to induce the rare fragile site at 16q22 [fra(16)(q22)] with distamycin-A and berenil. No chromosomal gaps, breaks, or reaRrangements at 16q22 were noted in lymphocytes treated from these cases, indicating that AMMoL patients with inv(16)(p13q22) do not always have the rare fragile site FRA16B, FRA(16)(q22). A predisposition to neoplasia in carriers of this fragile site is questionable.
Ohyashiki
K
K
Department of Internal Medicine, Tokyo Medical College, Japan.
Ohyashiki
J H
JH
Toyama
K
K
Ito
H
H
D002871:Chromosome Banding; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D005819:Genetic Markers; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*
D005819:Genetic Markers