Regional differences of vascular sensitivities in canine long posterior ciliary arteries.
Information is needed with regard to the vascular reactivities of ophthalmic and ciliary arteries in order to provide rational medical treatment of ocular disease by systemic administration of drugs. In the present study, vascular reactions of isolated proximal and distal portions of dog long posterior ciliary arteries (LPCAs) to norepinephrine (NE), prostaglandin F2 alpha (PGF2 alpha) and KCl were examined using the arterial-perfusion method, in the presence and absence of 2 kinds of antagonists, bunazosin (a selective alpha-1 adrenoceptor antagonist) and diltiazem (a calcium antagonist). In the present study, the proximal LPCA is defined as the region of LPCA on the optic nerve, and the distal one the region along the sclera except the anterior uvea. Each drug was injected by a microinjector into the endothelial side of an artery through a cannulated rubber tubing. Responses were recorded as changes in perfusion pressure. Results were as follows: 1) Three agents produced temporal vasoconstrictions, and the rank order of potency for inducing a vasoconstriction was NE greater than PGF2 alpha greater than KCl in each portion. 2) In these two regions of LPCAs, the maximum increase in perfusion pressure and the threshold dose for KCl were almost the same. 3) The maximum increase in perfusion pressure by PGF2 alpha was the same in these regions, but the threshold dose on proximal vessels was significantly larger than that on distal ones, indicating that the distal LPCAs were more sensitive to PGF2 alpha than the proximal ones. 4) The threshold dose for NE in the distal LPCAs was significantly greater than that in the proximal ones.(ABSTRACT TRUNCATED AT 250 WORDS)
Ohkubo
H
H
Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan.
Chiba
S
S
D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000502:physiology; D002924:Ciliary Body / Q000098:blood supply*; D004110:Diltiazem / Q000494:pharmacology; D015237:Dinoprost; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D014661:Vasoconstriction
D011460:Prostaglandins F; D011189:Potassium Chloride; D015237:Dinoprost; D004110:Diltiazem; D009638:Norepinephrine