Effects of isosorbide dinitrate on thromboxane A2 synthesis in carbon dioxide exposed platelets.
Isosorbide dinitrate (Nitorol R, 100 nmol/l) blocked an increase in thromboxane B2 concentration in human platelet-rich plasma caused by exposure to high CO2 tension, in the presence of arachidonic acid. Thromboxane B2 concentrations obtained at 1 or 2 mmol/l or arachidonic acid were not influenced by isosorbide dinitrate at low CO2 tension. Inhibitory action of isosorbide dinitrate on the thromboxane A2 synthesis appears to have a close relation to the site of CO2 action.
Ishikawa
N
N
Department of Pharmacology, Nagoya University School of Medicine, Japan.
Kainuma
M
M
Taki
K
K
Ichimura
I
I
D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002245:Carbon Dioxide / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007548:Isosorbide Dinitrate / Q000494:pharmacology*; D013928:Thromboxane A2 / Q000096:biosynthesis*
D002245:Carbon Dioxide; D013928:Thromboxane A2; D007548:Isosorbide Dinitrate