Inhibition of interferon-gamma may suppress allograft reactivity by T lymphocytes in vitro and in vivo.
The addition to mixed-leukocyte reactions of monoclonal antibodies to interferon-gamma abrogated alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity was not confined to in vitro models, since daily injection of the antibodies into CBA/J mice blocked the usual rejection of allogenic tumor cells.
Landolfo
S
S
Cofano
F
F
Giovarelli
M
M
Prat
M
M
Cavallo
G
G
Forni
G
G
D000818:Animals; D000911:Antibodies, Monoclonal; D003602:Cytotoxicity, Immunologic; D006084:Graft Rejection; D007371:Interferon-gamma / Q000502:physiology*; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D009368:Neoplasm Transplantation; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
D000911:Antibodies, Monoclonal; D007371:Interferon-gamma