title: Rapid ventricular filling in left ventricular hypertrophy: II. Pathologic hypertrophy.
abstract: To define the extent of left ventricular ejection and filling abnormalities in patients with mild hypertension, a non-imaging nuclear probe was used to generate high resolution time-activity curves in 25 patients with an average systolic blood pressure of 154 +/- 20 mm Hg and diastolic pressure of 98 +/- 8 mm Hg. The hypertensive patients did not meet electrocardiographic criteria for left ventricular hypertrophy, and none had evidence of ischemic or other cardiac disease. Compared with 25 age-matched normal subjects who had average systolic and diastolic pressures of 123 +/- 10 and 79 +/- 8 mm Hg, respectively, the hypertensive patients had a significantly lower ejection rate (2.00 +/- 0.20 versus 2.34 +/- 0.36 end-diastolic counts/s for the control group, p less than 0.05) and ejection fraction (58 +/- 4.9 versus 62 +/- 4.4) (p less than 0.05). The hypertensive patients had a markedly lower average rapid left ventricular filling rate (1.87 +/- 0.32 versus 2.69 +/- 0.41 counts/s for the control group, p less than 0.001). Although there was a modest inverse relation between echocardiographic left ventricular mass index and filling rate in the hypertensive patients (r = -0.59, p less than 0.01), 4 of 12 hypertensive patients with normal left ventricular mass index had a depressed filling rate. All of the hypertensive patients with increased left ventricular mass index had an abnormal left ventricular filling rate (less than 1.89 end-diastolic counts/s).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.forename: V E
authors.initials: VE
authors.lastname: Smith
authors.forename: P
authors.initials: P
authors.lastname: Schulman
authors.forename: M K
authors.initials: MK
authors.lastname: Karimeddini
authors.forename: W B
authors.initials: WB
authors.lastname: White
authors.forename: M K
authors.initials: MK
authors.lastname: Meeran
authors.forename: A M
authors.initials: AM
authors.lastname: Katz
mesh_terms: D000328:Adult; D001794:Blood Pressure; D006332:Cardiomegaly / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D004452:Echocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013318:Stroke Volume; D013997:Time Factors