Decreased antibody-dependent cellular cytotoxicity in minimal change nephrotic syndrome.
Secondary IgG response to a tetanus toxoid booster and in vitro measurement of immunoglobulin synthesis, antibody-dependent cellular cytotoxicity (ADCC) and gamma-interferon (IFN-gamma) production were evaluated in 20 healthy controls and in 17 children with minimal change nephrotic syndrome (MCNS), during the acute nephrotic phase and 6 months after remission. Defective responses were observed in all but IFN-gamma production during the acute nephrotic phase; these improved with disease remission. There was a significant correlation between decreases in vitro IgG production and ADCC reaction. These data indicate that defective antibody production is associated with decreased ADCC during the acute nephrotic phase of MCNS.
Lin
C Y
CY
Department of Medical Research, Veterans General Hospital, Taiwan, Republic of China.
D000293:Adolescent; D000920:Antibody-Dependent Cell Cytotoxicity; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D066298:In Vitro Techniques; D007223:Infant; D007371:Interferon-gamma / Q000096:biosynthesis; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009402:Nephrosis, Lipoid / Q000276:immunology*
D007074:Immunoglobulin G; D007371:Interferon-gamma