Effect of prednisolone on the rat bone calcium, phosphorus and magnesium concentration.
Adult male rats were given prednisolone (Urbason solubile = 6-methyl-prednisolone) in doses of 4 mg/100 g body weight for 10, 20 or 30 days and its effect on the calcium, phosphorus and magnesium content of their femurs was studied. At all the given intervals a statistically significant decrease in the magnesium content of the bone was found; the calcium content was significantly reduced only in the first phase of the experiment (at 10 days).
Simecková
A
A
Neradilová
M
M
Reisenauer
R
R
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology*; D010758:Phosphorus / Q000378:metabolism*; D051381:Rats
D010758:Phosphorus; D008274:Magnesium; D002118:Calcium; D008775:Methylprednisolone