title: Effects of atomic bomb radiation on the differentiation of B lymphocytes and on the function of concanavalin A-induced suppressor T lymphocytes.
abstract: The differentiation of peripheral blood B lymphocytes into immunoglobulin-producing cells (Ig-PC) by pokeweed mitogen (PWM) and the function of concanavalin A (Con A)-induced suppressor T lymphocytes were examined to elucidate the late effects of atomic bomb radiation. A total of 140 individuals, 70 with an exposure dose of 100 rad or more and an equal number with an exposure dose of 0 rad matched by sex and age, were selected from the Nagasaki Adult Health Study (AHS) sample. Both the differentiation of peripheral blood B lymphocytes into Ig-PC by PWM and the function of Con A-induced suppressor T lymphocytes tended to be more depressed in the exposed group than in the control group, but a statistically significant difference could not be observed between the two groups. The function of Con A-induced suppressor T lymphocytes tended to decrease with age, but a statistical significance was detected only for percentage suppression against IgM-PC.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: S
authors.initials: S
authors.lastname: Neriishi
authors.forename: T
authors.initials: T
authors.lastname: Ishimaru
authors.forename: N
authors.initials: N
authors.lastname: Shimba
authors.forename: H B
authors.initials: HB
authors.lastname: Hamilton
authors.forename: Y
authors.initials: Y
authors.lastname: Ohgushi
authors.forename: M
authors.initials: M
authors.lastname: Koyanagi
authors.forename: M
authors.initials: M
authors.lastname: Ichimaru
mesh_terms: D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000187:drug effects / Q000528:radiation effects*; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D009689:Nuclear Warfare; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000528:radiation effects*; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
chemical_list: D011043:Pokeweed Mitogens; D003208:Concanavalin A