Fenfluramine and amphetamine suppress dietary intake without affecting learned preferences for protein or carbohydrate cues.
The effects of pharmacological modulation of monoamine transmitter activity on genuine nutrient selection were assessed: that is, drug-induced changes in nutrient-specific dietary choice behaviour were measured, using rats that had learned to select an odour cueing protein content or carbohydrate content of the diet. Anorexigenic doses of DL-fenfluramine-HCl (1.25 or 2.5 mg/kg) and D-amphetamine2 SO4 (0.5 or 1.0 mg/kg) did not affect the selection of protein-paired or carbohydrate-paired odours by trained rats. This weighs against the claim that 5-hydroxytryptamine or catecholamine transmitters are involved in the selection of macronutrients, as distinct from selection between diets in response to sensory differences functionally unrelated to nutrient composition.
Gibson
E L
EL
Department of Psychology, University of Birmingham, U.K.
Booth
D A
DA
D000818:Animals; D003463:Cues; D003913:Dextroamphetamine / Q000494:pharmacology*; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005277:Fenfluramine / Q000494:pharmacology*; D005518:Food Preferences / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012903:Smell / Q000187:drug effects
D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D005277:Fenfluramine; D003913:Dextroamphetamine