title: Differentiation of the glomerular filtration barrier in the rat fetus: possible role of collagen.
abstract: Successive steps leading to the development of glomerular ultrafiltration properties were explored in rat fetuses. The appearance of the lamina densa of the glomerular basement membrane (GBM) concurrently with a sharp rise in collagen biosynthesis suggest a prominent role for these events in restricting permeability to plasma proteins. Sieving functions of the glomerular barrier are shown to depend on macromolecular architecture of the GBM, negative-fixed charges of the laminae rarae representing only one factor in maintaining the structure required for selective permeability.
authors.forename: H
authors.initials: H
authors.lastname: Bakala
authors.forename: A
authors.initials: A
authors.lastname: Geloso-Meyer
authors.forename: M
authors.initials: M
authors.lastname: Cheignon
authors.forename: J
authors.initials: J
authors.lastname: Schaeverbeke
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D002196:Capillaries / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D004563:Electrochemistry; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D007678:Kidney Glomerulus / Q000098:blood supply / Q000378:metabolism* / Q000648:ultrastructure; D008854:Microscopy, Electron; D010539:Permeability; D011247:Pregnancy; D051381:Rats
chemical_list: D003094:Collagen