CSF beta-endorphin and beta-lipotropin in Alzheimer's disease and multi-infarct dementia.
We measured CSF levels of the opioid peptides beta-endorphin and beta-lipotropin in patients with Alzheimer's disease, multi-infarct dementia and controls. In both dementia groups, the mean concentration of beta-endorphin was significantly lower than in controls. The mean beta-lipotropin levels did not differ significantly in the two groups. The low CSF beta-endorphin level may relate generally to dementia.
Sulkava
R
R
Erkinjuntti
T
T
Laatikainen
T
T
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D003704:Dementia / Q000134:cerebrospinal fluid*; D004723:Endorphins / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D001615:beta-Endorphin; D008083:beta-Lipotropin / Q000134:cerebrospinal fluid*
D004723:Endorphins; D001615:beta-Endorphin; D008083:beta-Lipotropin