Human genes for three complement components that regulate the activation of C3 are tightly linked.
A new cluster of complement component genes, including C4BP, C3bR, and FH, is described. Family segregation data indicate that FH is linked to the genes for C4-bp and C4bR, previously reported to be linked and to maintain linkage disequilibrium. This cluster is not linked to the major histocompatibility complex, which contains the genes for the complement components, C4, C2, and factor B, or to the C3 locus. These data further suggest that the organization of genes for functionally related proteins in clusters may be a rule for the complement system.
Rodriguez de Cordoba
S
S
Lublin
D M
DM
Rubinstein
P
P
Atkinson
J P
JP
D002352:Carrier Proteins / Q000235:genetics; D003167:Complement Activation; D003175:Complement C2 / Q000235:genetics; D003176:Complement C3 / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D003180:Complement C3b Inactivator Proteins / Q000235:genetics; D003181:Complement C4 / Q000235:genetics; D015934:Complement C4a; D015935:Complement C4b; D011415:Complement Factor B / Q000235:genetics; D017242:Complement Factor H; D003169:Complement Inactivator Proteins; D005796:Genes; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006023:Glycoproteins; D006801:Humans; D011951:Receptors, Complement / Q000235:genetics; D017463:Receptors, Complement 3b
C493495:CFH protein, human; D002352:Carrier Proteins; D003175:Complement C2; D003176:Complement C3; D003180:Complement C3b Inactivator Proteins; D003181:Complement C4; D003169:Complement Inactivator Proteins; D006023:Glycoproteins; D011951:Receptors, Complement; D017463:Receptors, Complement 3b; D015934:Complement C4a; D015935:Complement C4b; D017242:Complement Factor H; D011415:Complement Factor B