title: Combined effect of xylitol, NaF and ZnCl2 on growth and metabolism of Streptococcus sobrinus OMZ 176.
abstract: Xylitol, NaF and ZnCl2 in combination inhibited the growth of S. Sobrinus OMZ 176 when added to Brain Heart Infusion broth. Thin-layer chromatography, followed by autoradiography of cell extracts, was used to study the inhibiting mechanism. Glucose uptake was reduced, the glycolysis inhibited at the glucose 6-phosphate- and fructose- 1.6-diphosphate level and the accumulation of xylitol metabolites was increased. These effects in combination probably accounted for the inhibition of growth.
authors.affiliation: Dental Faculty, University of Oslo, Norway.
authors.forename: A A
authors.initials: AA
authors.lastname: Scheie
authors.forename: S
authors.initials: S
authors.lastname: Assev
authors.forename: G
authors.initials: G
authors.lastname: Rölla
mesh_terms: D001692:Biological Transport; D002470:Cell Survival; D002712:Chlorides / Q000008:administration & dosage*; D004357:Drug Synergism; D005636:Fructosephosphates / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D005958:Glucosephosphates / Q000378:metabolism; D012969:Sodium Fluoride / Q000008:administration & dosage*; D013291:Streptococcus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D014993:Xylitol / Q000008:administration & dosage*; D015032:Zinc / Q000008:administration & dosage*; D017967:Zinc Compounds
chemical_list: D002712:Chlorides; D005636:Fructosephosphates; D005958:Glucosephosphates; D017967:Zinc Compounds; C016837:zinc chloride; D012969:Sodium Fluoride; D005947:Glucose; D015032:Zinc; D014993:Xylitol