Potentiation of beta-endorphin effects by cholecystokinin antiserum in rats.
Intracerebroventricular administration of a C-terminal cholecystokinin (CCK) antiserum potentiated the analgesic and cataleptic effects of beta-endorphin. The results are opposite to those observed after injection of CCK-8. It was suggested that CCK-8 may play a physiological role antagonizing the action of beta-endorphin.
Itoh
S
S
Katsuura
G
G
Yoshikawa
K
K
Rehfeld
J F
JF
D000698:Analgesia; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology; D002766:Cholecystokinin / Q000276:immunology*; D004338:Drug Combinations; D004357:Drug Synergism; D004723:Endorphins / Q000494:pharmacology*; D006801:Humans; D007106:Immune Sera / Q000276:immunology* / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin
D004338:Drug Combinations; D004723:Endorphins; D007106:Immune Sera; D001615:beta-Endorphin; D002766:Cholecystokinin