Immunoregulatory functions of neoplastic lymphoid cells and their humoral products.
The immunologic functions of neoplastic lymphoid cells from 57 cases of lymphocytic leukemia or malignant lymphoma were examined in vitro where cells from 16 cases demonstrated regulatory functions in immunoglobulin production: 4 with helper activity, 8 with suppressor activity, 1 with presuppressor activity, and 3 with helper-inducer activity. The neoplastic lymphoid cells with such functions did not necessarily form E-rosettes, but because of the presence of human T-cell antigens, most of them appeared to be of the T-cell lineage. These regulatory functions were proven to be mediated by the humoral factor, at least in some of the cases tested. Neoplastic lymphoid cells from all 6 cases with Fc receptors showed antibody-dependent cell-mediated cytotoxicity, but lacked natural killer activity. These studies should provide further insight into the origin of the neoplastic cells.
Okawa
H
H
Inada
M
M
Suzuki
M
M
Yata
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000920:Antibody-Dependent Cell Cytotoxicity; D002469:Cell Separation; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002850:Chromatography, Gel; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology; D007945:Leukemia, Lymphoid / Q000276:immunology*; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000145:classification / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D011947:Receptors, Antigen, B-Cell