Temporal relationships of cholecystokinin release, pancreatobiliary secretion, and gastric emptying of a mixed meal.
The influence of gastric emptying of nutrients on plasma cholecystokinin and pancreatobiliary functions is poorly understood. We therefore temporally related the emptying of fat, protein, and glucose of a mixed meal to release of the gut hormones cholecystokinin, pancreatic polypeptide, and peptide YY and outputs of trypsin, lipase, bilirubin, and bile salts. Five healthy volunteers with a multilumen duodenal tube ingested a mixed meal with phase-specific markers for the aqueous phase, liquid fat, solid fat, and solid protein phases. Duodenal passage was determined by intraduodenal infusion of a second set of phase-specific nonabsorbable markers. Plasma cholecystokinin levels and pancreatobiliary secretions rose to a maximum at 30-60 min and then gradually declined (p less than 0.01) despite continued entry of protein and fat into the duodenum throughout the whole 4-h experimental period. High levels of both pancreatic polypeptide and peptide YY were observed in the last 2 h of the experiment. Release of factors capable of inhibiting cholecystokinin release and subsequently pancreatobiliary secretion may be responsible for the observed time-course.
Fried
M
M
Veterans Administration Medical Center, Los Angeles, California.
Mayer
E A
EA
Jansen
J B
JB
Lamers
C B
CB
Taylor
I L
IL
Bloom
S R
SR
Meyer
J H
JH
D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000032:analysis; D001663:Bilirubin / Q000032:analysis; D002766:Cholecystokinin / Q000097:blood / Q000378:metabolism*; D005502:Food; D005746:Gastric Emptying; D005766:Gastrointestinal Contents / Q000032:analysis; D006801:Humans; D008049:Lipase / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010191:Pancreatic Polypeptide / Q000097:blood / Q000378:metabolism*; D019894:Peptide YY; D010455:Peptides / Q000378:metabolism*; D014357:Trypsin / Q000032:analysis
D001647:Bile Acids and Salts; D010455:Peptides; D019894:Peptide YY; D010191:Pancreatic Polypeptide; D002766:Cholecystokinin; D008049:Lipase; D014357:Trypsin; D001663:Bilirubin