title: The effect of gonadotrophin releasing hormone analogue on height prognosis in growth hormone deficiency and normal puberty.
abstract: We have treated seven pubertal children, five (three female, two male) with growth hormone deficiency and two (one female, one male) with constitutional short stature with intranasal (D-Serine6) gonadotrophin releasing hormone (GnRH) analogue (Buserelin) for a mean of 0.84 years (range, 0.5-1.3). Treatment was successful in arresting pubertal development but there was no improvement in final height prognosis.
authors.affiliation: Department of Growth and Development, Institute of Child Health, London, United Kingdom.
authors.forename: R
authors.initials: R
authors.lastname: Stanhope
authors.forename: C G
authors.initials: CG
authors.lastname: Brook
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D001827:Body Height / Q000187:drug effects; D002064:Buserelin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006128:Growth / Q000187:drug effects; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D008297:Male; D011379:Prognosis; D011627:Puberty / Q000187:drug effects*; D012741:Sexual Maturation / Q000187:drug effects
chemical_list: D013006:Growth Hormone; D002064:Buserelin