A porcine model for the study of liver regeneration.
A technique of 65% partial hepatectomy in the pig is described. Thymidine kinase activity and mitotic index were used as indices of liver regeneration. Thymidine kinase activity increased from a baseline value of 1526 +/- 256 to a maximum of 23992 +/- 4966 dpm/mg protein on the third day after partial hepatectomy. The mitotic index also increased from 0-13.3 +/- 1.66 on the third postoperative day. The indices of regeneration remained unchanged after sham operation.
Kahn
D
D
Department of Surgery, University of Cape Town Observatory, South Africa.
Hickman
R
R
Terblanche
J
J
D000818:Animals; D005260:Female; D006498:Hepatectomy; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D008940:Mitotic Index; D008954:Models, Biological; D013552:Swine; D013937:Thymidine Kinase / Q000378:metabolism
D013937:Thymidine Kinase