A rapid decline in external Ca2+ induces Ca2+ mobilization in bovine adrenal glomerulosa cells.
Bovine adrenal glomerulosa cells perifused with M 199 containing 1 mM Ca2+ showed a transient increase in 45Ca2+ when the external Ca2+ was decreased. The efflux observed in the presence of 100 nM angiotensin II was similar to that observed when the external Ca2+ was changed from 1 mM to 50 microM. This efflux is the result of the transient activation of the PIP2 hydrolysis with the subsequent production of inositol-trisphosphate.
Foster
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Departamento de Fisiología y Biofísica, Facultad de Medicina, Universidad de Chile, Santiago.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes / Q000378:metabolism*; D002417:Cattle; D004533:Egtazic Acid / Q000378:metabolism*; D015544:Inositol 1,4,5-Trisphosphate / Q000096:biosynthesis*; D051381:Rats; D015384:Zona Glomerulosa / Q000166:cytology / Q000378:metabolism*
D002132:Calcium Radioisotopes; D004533:Egtazic Acid; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium