[Relation between plasma Ara-C and intracellular Ara-CTP levels by intermediate dose and high dose Ara-C administration in the treatment of AML].
Plasma level of cytosine arabinoside (Ara-C) and intracellular cytosine arabinoside triphosphate (Ara-CTP) in peripheral blood and bone marrow were measured in 8 patients with non treated acute myelogenous leukemia. Ara-C was administered by 1 hr infusion (3 g/m2 and 500 mg/m2) and was followed for 12 hrs. The AUC of Ara-C in plasma following 3 g/m2 infusion were greater than the 500 mg/m2 (p less than 0.05). Intracellular Ara-CTP in peripheral blood following 3 g/m2 and 500 mg/m2 infusions were on the same level, after 1 hr. But AUC of intracellular Ara-CTP following 3 g/m2 infusion was greater than 500 mg/m2. There was a correlation between AUC of Ara-C in the peripheral blood (p less than 0.01). Intracellular Ara-CTP in the bone marrow and peripheral blood showed a similar level. Intracellular Ara-CTP in bone marrow was lower than in peripheral blood, however, there was no correlation between intracellular Ara-CTP in bone marrow and in peripheral blood.
Yoshida
T
T
3rd Dept. of Medicine, Kanazawa University School of Medicine.
Kobayashi
K
K
Nakamura
S
S
Ohtake
S
S
Itoh
K
K
Kanno
M
M
Hirai
J
J
Yasushi
Matsuda
T T
TT
D000328:Adult; D000368:Aged; D001085:Arabinofuranosylcytosine Triphosphate / Q000032:analysis*; D001088:Arabinonucleotides / Q000032:analysis*; D001853:Bone Marrow / Q000378:metabolism*; D001854:Bone Marrow Cells; D003561:Cytarabine / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged
D001088:Arabinonucleotides; D003561:Cytarabine; D001085:Arabinofuranosylcytosine Triphosphate