[Preventive effect of fosfomycin on the renal toxicity of cisplatin].
Cisplatin caused toxic effects in adult male rats, such as renal disturbance, decrease of platelet and WBC, increase of RBC, elevation of GPT and GOT activity, decrease of plasma protein and albumin, loss of body weight gain and lethal effect when treated intravenously with 1 mg/kg/day of cisplatin for 12 days. Fosfomycin (FOM) exerted preventive effects on the renal disturbance, the changes in blood cells and plasma protein and the lethal effect induced by cisplatin when treated with a combination of FOM and cisplatin. However, FOM did not prevent the cisplatin-induced effects on GPT and GOT activity and body weight gain. These results suggest that FOM prevents the cisplatin-induced disturbance of renal and hematopoietic function but does not the cisplatin-induced hepatic disturbance.
Kurebe
M
M
Niizato
T
T
Sanda
M
M
Sasaki
H
H
Hayasaka
H
H
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000097:blood; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D002945:Cisplatin / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005578:Fosfomycin / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects*; D007684:Kidney Tubules / Q000187:drug effects; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013047:Specific Pathogen-Free Organisms
D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002945:Cisplatin