title: The influence of age on the onset of anaesthesia with midazolam.
abstract: There was a considerable individual variation in response to a standard induction dose of 0.3 mg/kg midazolam in unpremedicated patients. This is shown by variations in time to onset of sleep and the fact that about one quarter of subjects did not lose consciousness in 3 minutes. In 166 fit patients a good negative correlation was demonstrated between the age of the patients and time to loss of consciousness. Patients over 50 years differed from younger patients in a greater reliability of effect and significantly shorter induction time. In elderly patients midazolam is a more reliable induction agent than in the young.
authors.forename: J W
authors.initials: JW
authors.lastname: Dundee
authors.forename: N J
authors.initials: NJ
authors.lastname: Halliday
authors.forename: P G
authors.initials: PG
authors.lastname: Loughran
authors.forename: K W
authors.initials: KW
authors.lastname: Harper
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000771:Anesthesia, Intravenous; D000777:Anesthetics; D001569:Benzodiazepines; D006801:Humans; D008874:Midazolam; D008875:Middle Aged; D013997:Time Factors
chemical_list: D000777:Anesthetics; D001569:Benzodiazepines; D008874:Midazolam