A mechanism for the potentiation of the cytotoxic effects of antimetabolites drugs (FT-207, 5FU) by hyperthermia.
This study demonstrates that the cytotoxicity of FT-207 was potentiated with elevated temperatures. This result leads us to the hypothesis that the heat-produced superoxide radicals could metabolize and degradate FT-207 to 5FU at membrane or cytoplasm.
Iwagaki
H
H
First Department of Surgery, Okayama University Medical School, Japan.
Fuchimoto
S
S
Shiiki
S
S
Miyake
M
M
Orita
K
K
D002460:Cell Line / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms / Q000201:enzymology / Q000473:pathology*; D003131:Combined Modality Therapy; D003600:Cytosol / Q000201:enzymology; D005472:Fluorouracil / Q000494:pharmacology*; D006358:Hot Temperature; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects; D013385:Succinate Dehydrogenase / Q000032:analysis; D005641:Tegafur / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014410:Tumor Stem Cell Assay
D005641:Tegafur; D013385:Succinate Dehydrogenase; D005472:Fluorouracil