title: Different effects of norepinephrine and KCl on the cytosolic Ca2+-tension relationship in vascular smooth muscle of rat aorta.
abstract: Norepinephrine and KCl induced a concentration-dependent increase in the cytosolic Ca2+ level [( Ca2+]cyt) measured either by intracellular fura 2-Ca2+ fluorescence or by 45Ca2+ uptake. Muscle contraction in isolated rat aortic strips was also increased although a greater contraction was induced by norepinephrine than by KCl at the same [Ca2+]cyt. This result suggests that the contraction of vascular smooth muscle is regulated by [Ca2+]cyt and also by other factor(s).
authors.affiliation: Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Karaki
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Ozaki
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011189:Potassium Chloride; D002118:Calcium; D009638:Norepinephrine