[Psychopathologic prediction of ambulatory doxepin response. A replication trial].
This study tries to replicate findings of a previous outpatient study, which revealed some clinical predictors of doxepine response in depressed patients. 314 depressed outpatients were treated by a total of 262 private practice psychiatrists for 6 weeks with 100 mg doxepine daily. The following findings of the previous study could be confirmed: 74% of the patients were therapy responders (score on the Hamilton Depression Scale after 6 weeks less than or equal to 8); unpredictability of diagnostic subtyping into endogenous and non-endogenous depression (clinically according to ICD-9 and operationally according to the Newcastle Scale); response-predictability of the personality assessment as not being deviant, defined according to the Newcastle Scale (no previous "nervous breakdowns", no previous neurotic symptoms, no severe social maladaptation); response-predictability of an improvement after 2 weeks over the initial Hamilton score of greater than or equal to 30%. The practical relevance of these three findings for outpatient therapy with antidepressive drugs is stressed.
Philipp
M
M
Psychiatrische Klinik, Universität Mainz.
Maier
W
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004316:Doxepin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011358:Product Surveillance, Postmarketing; D011379:Prognosis; D011581:Psychological Tests
D004316:Doxepin
Psychopathologische Prädiktion des ambulanten Doxepin-Response. Ein Replikationsversuch.