title: Highly toxinogenic but avirulent Park-Williams 8 strain of Corynebacterium diphtheriae does not produce siderophore.
abstract: The highly toxinogenic Park-Williams 8 strain of Corynebacterium diphtheriae grows slowly in vitro and is avirulent. C. diphtheriae Park-Williams 8 is defective in iron uptake and does not produce the corynebacterial siderophore corynebactin. Addition of partially purified corynebactin stimulated iron uptake and growth of iron-deprived C. diphtheriae Park-Williams 8 cells.
authors.forename: L M
authors.initials: LM
authors.lastname: Russell
authors.forename: R K
authors.initials: RK
authors.lastname: Holmes
mesh_terms: D001693:Biological Transport, Active; D003353:Corynebacterium diphtheriae / Q000254:growth & development / Q000378:metabolism* / Q000472:pathogenicity; D004167:Diphtheria Toxin / Q000096:biosynthesis*; D004758:Enterobactin / Q000031:analogs & derivatives; D007501:Iron / Q000378:metabolism; D007502:Iron Chelating Agents / Q000096:biosynthesis* / Q000494:pharmacology; D017262:Siderophores; D014774:Virulence
chemical_list: D004167:Diphtheria Toxin; D007502:Iron Chelating Agents; D017262:Siderophores; D004758:Enterobactin; C044318:corynebactin; D007501:Iron