title: An external stimulus that mimics Mls locus responses.
abstract: The response to a novel set of T cell mitogens has been analysed and compared to the response to Mls locus differences. These polyclonal T cell activators, staphylococcal enterotoxins A and B, stimulate T cells in a way that requires an antigen-presenting cell bearing class II MHC products and involves the CD4:T cell receptor complex. However, the specificity of MHC recognition by the T cell receptor is lost in this response. Thus, these mitogens produce a response with characteristics similar to that induced by Mls locus differences. These mitogens can be used to analyse the immunobiology of this response, and may help in understanding and identifying the Mls locus product as well.
authors.affiliation: Department of Pathology, Howard Hughes Institute, Yale University School of Medicine, New Haven, CT 06510.
authors.forename: C A
authors.initials: CA
authors.lastname: Janeway
authors.forename: J
authors.initials: J
authors.lastname: Chalupny
authors.forename: P J
authors.initials: PJ
authors.lastname: Conrad
authors.forename: S
authors.initials: S
authors.lastname: Buxser
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D002999:Clone Cells / Q000276:immunology; D004768:Enterotoxins / Q000494:pharmacology; D000949:Histocompatibility Antigens Class II; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D051379:Mice; D016747:Minor Lymphocyte Stimulatory Antigens; D008934:Mitogens; D011948:Receptors, Antigen, T-Cell; D013601:T-Lymphocytes / Q000276:immunology*; D014407:Tumor Cells, Cultured / Q000276:immunology
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D004768:Enterotoxins; D000949:Histocompatibility Antigens Class II; D016747:Minor Lymphocyte Stimulatory Antigens; D008934:Mitogens; D011948:Receptors, Antigen, T-Cell; C026066:enterotoxin A, Staphylococcal; C031818:enterotoxin B, staphylococcal