title: Nuclear medicine studies of aging--V. Uptake of 67Ga and 111In in the femoral vessels.
abstract: Fifty-nine males who had gallium-67-citrate or indium-111-oxine WBC scintigraphy (Ga/In) had the images reviewed to determine if increased activity was present in the femoral vessels and, if so, whether this was age related. The 59 subjects showed an age-associated increasing bilateral uptake (13% of 15 patients younger than 40 years, to 71% of the 7 who were older than 69 years). The combined unilateral and bilateral femoral uptake rose from 27% in those under age 40, to 86% in those over age 69. The group of 59 males included 30 (51%) who had bone scintigraphy with 99mTc-MDP within 3 months of the Ga/In examination. These men showed the expected increase in femoral vessel 99mTc-MDP uptake with age. Femoral vessel activity was more commonly observed with 99mTc-MDP than with Ga/In. Thus both Ga/In and 99mTc-MDP accumulate more frequently in the femoral vessels with advancing age. Ga/In displays this age-related phenomenon to a lesser extent than 99mTc-MDP.
authors.affiliation: Department of Radiology, University of Texas Health Science Center, Dallas.
authors.forename: T R
authors.initials: TR
authors.lastname: Simon
authors.forename: R P
authors.initials: RP
authors.lastname: Spencer
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood / Q000378:metabolism*; D002951:Citrates / Q000493:pharmacokinetics; D019343:Citric Acid; D005269:Femur / Q000098:blood supply* / Q000000981:diagnostic imaging; D006801:Humans; D006912:Hydroxyquinolines; D007205:Indium Radioisotopes; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D015125:Oxyquinoline / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D011877:Radionuclide Imaging
chemical_list: D002951:Citrates; D006912:Hydroxyquinolines; D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C032950:indium oxine; D019343:Citric Acid; D015125:Oxyquinoline