title: [Participation of endogenous opioid peptides in the pathogenesis of motion sickness].
abstract: Investigations were performed with 19 healthy male volunteers to specify a possible role of endogenous opioid peptides in the pathogenesis of motion sickness. For this purpose the test subjects were administered naloxone, a specific antagonist of opiates and opioids, before rotation and during rotation in a BU-4 armchair at a rate of 30 rpm. In addition, the content of beta-endorphin in blood plasma was measured. It was discovered that naloxone exerts both prophylactic and therapeutic effects as regards the simulated motion sickness. In this respect it was more efficacious than the reference drug scopolamine. After rotation there was a significant increase in the beta-endorphin content in the blood plasma of the test subjects. It is assumed that endogenous opioid peptides (in particular beta-endorphin) may be directly involved in the genesis of vestibulo-vegetative disorders in motion sickness.
authors.forename: V V
authors.initials: VV
authors.lastname: Iasnetsov
authors.forename: O P
authors.initials: OP
authors.lastname: Vakulina
authors.forename: V V
authors.initials: VV
authors.lastname: Sabaev
authors.forename: A V
authors.initials: AV
authors.lastname: Mokrousova
authors.forename: S K
authors.initials: SK
authors.lastname: Karsanova
mesh_terms: D000054:Acceleration; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003312:Coriolis Force; D004723:Endorphins / Q000097:blood / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009041:Motion Sickness / Q000209:etiology* / Q000503:physiopathology; D009270:Naloxone / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects; D012399:Rotation; D012601:Scopolamine / Q000494:pharmacology; D013997:Time Factors; D001615:beta-Endorphin
chemical_list: D004723:Endorphins; D009270:Naloxone; D001615:beta-Endorphin; D012601:Scopolamine
vernacular_title: Ob uchastii éndogennykh opioidnykh peptidov v patogeneze bolezni dvizheniia.