Influence of some ergot alkaloids on the cerebral reduced glutathione.
Dose-related changes of the reduced glutathione were evaluated in forebrains from male Wistar rats aged 10 months after chronic i.p. treatment for two months with the ergot alkaloids dihydroergocristine and dihydroergocriptine. The results indicate that, within a specific dose-range, the concentration of the cerebral reduced glutathione may be modified by exogenous intervention.
Gorini
A
A
Istituto di Farmacologia, Università di Pavia, Italy.
Arnaboldi
R
R
Vercesi
L
L
Dossena
M
M
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004088:Dihydroergotoxine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004876:Ergot Alkaloids / Q000494:pharmacology*; D005978:Glutathione / Q000031:analogs & derivatives* / Q000378:metabolism; D019803:Glutathione Disulfide; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004876:Ergot Alkaloids; D004088:Dihydroergotoxine; D005978:Glutathione; D019803:Glutathione Disulfide