Karyotypic evidence for the leukemic involvement of the erythroblasts in erythroleukemia.
With the use of a monoclonal anti-glycophorin A antibody and flow cytometric cell sorting, an erythroleukemic bone marrow sample was separated in highly purified erythroblast and myeloblast fractions. Similar karyotypic anomalies were found in both cell populations as in the unseparated bone marrow. This study confirms that acute nonlymphocytic leukemia can originate at the level of a multipotential hemopoietic stem cell.
Berneman
Z N
ZN
Laboratory of Hematology, University of Antwerp, Belgium.
van Bockstaele
D R
DR
Van den Bergh
M
M
Van Roy
B
B
Roete
L
L
De Bock
R
R
Korthout
M
M
Peetermans
M E
ME
Dumon
J
J
D000911:Antibodies, Monoclonal; D001854:Bone Marrow Cells; D002469:Cell Separation; D004900:Erythroblasts / Q000032:analysis*; D005434:Flow Cytometry; D006021:Glycophorins / Q000032:analysis; D006801:Humans; D007621:Karyotyping; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D000911:Antibodies, Monoclonal; D006021:Glycophorins