title: The effects of hypertension on the wall of the large intracranial arteries with special reference to the changes of some connective tissue elements.
abstract: The effect of hypertension on the wall of the major cerebral arteries of 62 patients was investigated at the light microscopical level. This series does not include patients with atherosclerosis of the large intracranial arteries. In hypertensive individuals the intracranial arteries showed concentric intimal thickening. Furthermore, the collagenous fibers occurred in the media as early as in the third decade of life in place of reticular fibers. On the basis of literary data and our findings one may suppose that under permanent mechanical influence the arterial smooth muscle cells synthetize predominantly collagenous fibers instead of reticular fibers.
authors.affiliation: Department of Neurology and Psychiatry, University of Debrecen, Medical School, Hungary.
authors.forename: K
authors.initials: K
authors.lastname: Hegedüs
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002536:Cerebral Arteries / Q000473:pathology*; D002543:Cerebral Hemorrhage; D003238:Connective Tissue / Q000473:pathology*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D006973:Hypertension / Q000473:pathology*; D008297:Male; D008875:Middle Aged