title: Locally advanced adenocarcinoma of the breast without distant metastasis treated with multimodal therapies.
abstract: Locally advanced breast cancer has been treated with a variety of primary treatments with or without adjuvant therapies. This study combines radiation, chemotherapy, and surgery as a multimodal program for Stage III breast cancer. Radiation was started on day 1: 4600 rad were administered to the breast and 4500 rad were administered to the axilla and supraclavicular areas. Chemotherapy was started on day 1 with weekly intravenous injections of 5-fluorouracil (5FU) (300 mg/m2), methotrexate (15 mg/m2), vincristine (0.625 mg/m2), oral cytoxan (60 mg/m2), and prednisone (30 mg/m2 for two weeks, then 20 mg/m2 for two weeks, then 10 mg/m2 for two weeks). The 5FU, methotrexate, and cytoxan were given for 10 months postsurgery. This combination of modalities produced a complete remission in all 13 patients with Stage III breast cancer after two months of therapy. The median disease-free period was two years. The median survival was 44 months. This approach to the management of Stage III breast cancer is worthy of further investigation.
authors.affiliation: Oncology Service, Providence Hospital, Southfield, Michigan 48075.
authors.forename: C B
authors.initials: CB
authors.lastname: Vaughn
authors.forename: J
authors.initials: J
authors.lastname: Chapman
authors.forename: S S
authors.initials: SS
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Young
authors.forename: D
authors.initials: D
authors.lastname: Amores
authors.forename: B
authors.initials: B
authors.lastname: Chinn
authors.forename: H
authors.initials: H
authors.lastname: Duffin
authors.forename: G
authors.initials: G
authors.lastname: Groshko
authors.forename: E
authors.initials: E
authors.lastname: Maniscalco
authors.forename: A
authors.initials: A
authors.lastname: McGinnity
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D002985:Clinical Protocols; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D009367:Neoplasm Staging; D010865:Pilot Projects; D011882:Radiotherapy, High-Energy