title: "In vivo" kinetics of eosinophils and mast cells in experimental murine schistosomiasis.
abstract: During the schistosomiasis infection there is a "dance of the cells", varying from site to site and related to the time of infection. 1--Eosinophil levels exhibit a bimodal pattern, with the first peak related to the egg deposition and maturation and increased Kupfferian hyperplasia; the second peak precedes the death of some adult worms; 2--The peritoneal eosinophilic levels are inversely proportional to the blood eosinophilic levels; 3--Eosinopoiesis in the bone marrow begins at day 40, reaching the highest levels at day 50 and coincides with hepatic eosinophilic and neutrophilic metaplasia; 4--Peritoneal mast cell levels present a bimodal pattern similar to the blood eosinophils, and inverse to the peritoneal eosinophils. They also show a cyclic behaviour within the hepatic and intestinal granulomas. Integral analysis of the events related to the eosinophils in the blood, bone marrow, peritoneal cavity and hepatic and intestinal granulomas allows the detection of two important eosinophilic phases: the first is due to mobilization and redistribution of the marginal pool and the second originates from eosinophilic production in the bone marrow and liver. The productive phase is characterized by an increase in the number of eosinophils and monocyte/macrophages, and a decrease in neutrophils and stabilization of megakariocytes and erithroid lineages.
authors.affiliation: Instituto Oswaldo Cruz, Departamento de Patologia, Rio de Janeiro, Brasil.
authors.forename: H L
authors.initials: HL
authors.lastname: Lenzi
authors.forename: A C
authors.initials: AC
authors.lastname: Sobral
authors.forename: J A
authors.initials: JA
authors.lastname: Lenzi
mesh_terms: D000818:Animals; D002452:Cell Count; D002455:Cell Division; D004802:Eosinophilia / Q000209:etiology / Q000473:pathology; D004804:Eosinophils / Q000473:pathology*; D005260:Female; D006099:Granuloma / Q000473:pathology; D008297:Male; D008407:Mast Cells / Q000473:pathology*; D051379:Mice; D012555:Schistosomiasis mansoni / Q000150:complications / Q000473:pathology*