title: Inhibition by antiepileptics of carbachol but not lithium- or 5-methoxytryptamine-induced wet dog shakes in rats.
abstract: The influence of antiepileptic drugs on the wet dog shakes (WDS) induced by intracerebroventricular injections of carbachol (30 micrograms icv) was investigated in rats. Diphenylhydantoin (DPH, 8 and 4 mg/kg), diazepam (0.4, 0.2 and 0.1 mg/kg), phenobarbital (12.5, 6.25 and 3.12 mg/kg), sodium valproate (Depakine, 200, 100 and 50 mg/kg) and trimethadione (200, 100 and 50 mg/kg) given ip inhibited the WDS in a dose-dependent manner. These drugs at the same doses did not change the intensity of shaking behavior induced by lithium chloride or 5-hydroxytryptamine. As the antiepileptic drugs tested in these experiments did not have anticholinergic activity and at used doses were not able to prevent electrical convulsions or pentetrazol-induced seizures, it appears that carbachol-induced WDS could be connected with convulsive activity and could be the initial stage of seizures.
authors.affiliation: Department of Pharmacology, Medical Academy, Lublin, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Sieklucka-Dziuba
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
mesh_terms: D008735:5-Methoxytryptamine / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002217:Carbachol / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D003975:Diazepam / Q000494:pharmacology; D007276:Injections, Intraventricular; D008094:Lithium / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D008297:Male; D010672:Phenytoin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin; D012702:Serotonin Antagonists; D013997:Time Factors; D014293:Trimethadione / Q000494:pharmacology; D014635:Valproic Acid / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D012702:Serotonin Antagonists; D012701:Serotonin; D008735:5-Methoxytryptamine; D014635:Valproic Acid; D010672:Phenytoin; D002217:Carbachol; D008094:Lithium; D003975:Diazepam; D014293:Trimethadione