Casein kinase 2 activity increases in the prereplicative phase of liver regeneration.
Cytosolic casein kinase activity increased up to 2-fold in the first 6 h after partial hepatectomy and then decreased to control values. This increase was due mainly to casein kinase 2, which reached maximal values at 6-8 h of liver regeneration. In contrast, casein kinase 1 showed a smaller increase at 4 h and then started to decrease reaching values of about 70% of control at 16 h. The increase in total casein kinase 2 was accompanied with an activation of the enzyme, as determined by the low/high beta-casein activity ratio assay. Administration of an acute dose of glucagon to control rats also increased the activity ratio but failed to cause any rise in total casein kinase 2 activity.
Pérez
M
M
Departament de Bioquimica i Biologia Molecular, Facultat de Ciències, Universitat Autònoma de Barcelona, Spain.
Grande
J
J
Itarte
E
E
D000818:Animals; D047388:Casein Kinases; D004789:Enzyme Activation / Q000187:drug effects; D005934:Glucagon / Q000494:pharmacology; D006498:Hepatectomy; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008115:Liver Regeneration; D008297:Male; D011494:Protein Kinases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D005934:Glucagon; D011494:Protein Kinases; D047388:Casein Kinases