Enhancement of hematoporphyrin derivative uptake in vitro and in vivo by tumor cells in the presence of lanthanum.
Hematoporphyrin derivative is currently used as a photochemotherapeutic agent in the treatment of neoplasms. The uptake of hematoporphyrin derivative was determined in vitro and as a function of time with Ehrlich ascites cells in the presence of lanthanum and in vivo with VFM1, tumor-bearing mice pretreated by intratumoral injection of LaCl3. Our results indicate that the treatment with lanthanum increases the uptake of hematoporphyrin derivative by tumor cells.
Crone-Escanye
M C
MC
Anghileri
L J
LJ
Robert
J
J
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D004347:Drug Interactions; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000378:metabolism*; D066298:In Vitro Techniques; D007811:Lanthanum / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008665:Metalloporphyrins; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D015609:Organotechnetium Compounds; D011838:Radiation-Sensitizing Agents / Q000378:metabolism*; D012208:Rhabdomyosarcoma / Q000378:metabolism*; D013667:Technetium
D006415:Hematoporphyrins; D008665:Metalloporphyrins; D015609:Organotechnetium Compounds; D011838:Radiation-Sensitizing Agents; C040432:technetium Tc 99m hematoporphyrin derivative; C028521:lanthanum chloride; D017324:Hematoporphyrin Derivative; D007811:Lanthanum; D013667:Technetium