title: The synthesis of peptides in enteroendocrine cells developing in explanted presumptive endoderm.
abstract: Peptide immunoreactivity was studied in grafts of endoderm from chick or quail embryos (19 hours, corresponding to stage 4- to 5 according to Hamburger and Hamilton) in the coelom of a 48 hour host embryo. The presence of gastrin, glucagon, cholecystokinin, VIP, substance P, somatostatin, bombesin, motilin, secretin, pancreatic polypeptide, neurotensin and insulin was demonstrated. The nature of the peptide(s) generally matched the regional differentiation of the enteric epithelium and the underlying mesodermal components. The findings are compatible with the concept of heterogeneity of the endoderm due to migration of epiblast derived cells.
authors.affiliation: Department of Anatomy and Embryology, University of Limburg, Maastricht, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Drukker
authors.forename: E A
authors.initials: EA
authors.lastname: Terwindt-Rouwenhorst
authors.forename: E L
authors.initials: EL
authors.lastname: Wiertz-Hoessels
mesh_terms: D000818:Animals; D002642:Chick Embryo; D004702:Endocrine Glands / Q000196:embryology* / Q000378:metabolism; D004707:Endoderm / Q000378:metabolism / Q000637:transplantation*; D007150:Immunohistochemistry; D009479:Neuropeptides / Q000378:metabolism*; D011784:Quail
chemical_list: D009479:Neuropeptides