title: Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.
abstract: Complementary DNA clones encoding a glucose transporter-like protein have been isolated from a human fetal skeletal muscle cDNA library. The 496-amino acid fetal muscle glucose transporter-like protein has 64.4 and 51.6% identity with the previously described human erythrocyte/HepG2 and liver glucose transporter sequences, respectively. RNA blotting studies indicate that transcripts encoding this glucose transporter-like protein are present in most tissues, although their relative abundance varies. The gene encoding this protein has been localized to human chromosome 12p13.3. The identification and characterization of a third human glucose transporter-related protein suggests that there is a family of proteins having similar sequences and structures which are involved in nutrient transport by mammalian cells.
authors.affiliation: Howard Hughes Medical Institute, Department of Biochemistry, University of Chicago, Illinois 60637.
authors.forename: T
authors.initials: T
authors.lastname: Kayano
authors.forename: H
authors.initials: H
authors.lastname: Fukumoto
authors.forename: R L
authors.initials: RL
authors.lastname: Eddy
authors.forename: Y S
authors.initials: YS
authors.lastname: Fan
authors.forename: M G
authors.initials: MG
authors.lastname: Byers
authors.forename: T B
authors.initials: TB
authors.lastname: Shows
authors.forename: G I
authors.initials: GI
authors.lastname: Bell
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002871:Chromosome Banding; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis; D006801:Humans; D008969:Molecular Sequence Data; D009004:Monosaccharide Transport Proteins / Q000032:analysis / Q000235:genetics*; D009132:Muscles / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis
chemical_list: D009004:Monosaccharide Transport Proteins; D012333:RNA, Messenger; D004247:DNA