Sensitization against the parasite antigen Sj26 is not sufficient for consistent expression of resistance to Schistosoma japonicum in mice.
Mice immunized with purified antigen preparations produced in Escherichia coli and containing the glutathione S-transferase (GST) isoenzyme of Schistosoma japonicum (Sj26) can be partially resistant to infection with this parasite. Maximum resistance was approximately 50% and no protection was obtained in BALB/c mice, known low responders to Sj26. Although only Freund's complete adjuvant has been used, the data obtained indicate that satisfactory levels of resistance to S. japonicum will not be attained by vaccination with Sj26 alone. Other antigens, including the additional GST isoenzyme of S. japonicum Sj28, will probably be required to establish whether Sj26 will be an important component of a defined multivalent vaccine against schistosomiasis japonica.
Mitchell
G F
GF
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Garcia
E G
EG
Davern
K M
KM
Tiu
W U
WU
Smith
D B
DB
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D005260:Female; D005982:Glutathione Transferase / Q000276:immunology; D007527:Isoenzymes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D012554:Schistosomiasis japonica / Q000517:prevention & control*; D014611:Vaccination
D000947:Antigens, Helminth; D007527:Isoenzymes; D005982:Glutathione Transferase