title: HLA and altered sex ratios in juvenile rheumatoid arthritis sibships.
abstract: Analysis of sex ratio in 301 siblings of 150 patients with early-onset pauciarticular juvenile rheumatoid arthritis revealed a male-to-female ratio of 1:2.00 in sibships with an HLA-B44+ proband, compared with a ratio of 1:1.05 in other sibships (G2 = 6.07, df = 1, p = 0.014). The siblings had a sex ratio of 1:0.8, when the HLA-B44 antigen was present in either parent but not transmitted to the proband. The capacity to distort the sex ratio was limited therefore to disease-associated HLA-B44 haplotypes.
authors.affiliation: Division of Rheumatology, Children's Hospital Medical Center, Cincinnati, OH 45229-2899.
authors.forename: C
authors.initials: C
authors.lastname: Van Kerckhove
authors.forename: K
authors.initials: K
authors.lastname: Balakrishnan
authors.forename: J E
authors.initials: JE
authors.lastname: Levinson
authors.forename: M G
authors.initials: MG
authors.lastname: Larson
authors.forename: D N
authors.initials: DN
authors.lastname: Glass
mesh_terms: D000293:Adolescent; D000328:Adult; D001171:Arthritis, Juvenile / Q000235:genetics / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics; D059948:HLA-B44 Antigen; D006239:Haplotypes; D006801:Humans; D007223:Infant; D008297:Male; D012744:Sex Ratio
chemical_list: D006680:HLA Antigens; D015235:HLA-B Antigens; D059948:HLA-B44 Antigen