Clonal trisomy 8 is associated with myeloid phenotype rather than the neoplastic transformation in acute leukemia.
Our studies of an acute leukemia with a clonal t(1;11) marker have demonstrated a conversion from pre-B cell to myelomonocytic phenotype associated with the acquisition of trisomy 8. This finding suggests that trisomy 8, a frequent clonal abnormality in acute myeloid leukemias, may be associated with the myeloid phenotype rather than the neoplastic transformation. A permanent myelomonocytic cell line, designated UF-SK1, has been established from leukemic cells with a 47,XX,+8,t(1;11) (p31;q25) karyotype and shown to have myelomonocytic characteristics, including phorbol ester-induced differentiation to macrophages. This new cell line will be a valuable tool in the study of leukemogenesis and lineage commitment.
Cassano
W F
WF
Department of Pediatrics, University of Florida, Gainesville 32610.
Hintz
M S
MS
D000208:Acute Disease; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002898:Chromosomes, Human, Pair 8; D002999:Clone Cells; D005260:Female; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000235:genetics*; D007951:Leukemia, Myeloid / Q000235:genetics / Q000473:pathology*; D009364:Neoplasm Recurrence, Local; D010641:Phenotype; D014178:Translocation, Genetic; D014314:Trisomy