Mechanisms of pathogenicity in mycobacteria.
The purpose of this article is to review current knowledge about the mechanisms of pathogenicity of mycobacteria. The following aspects of the problem are discussed: chemically-defined compounds implicated in the mechanisms of pathogenicity; location in the cell wall of these compounds and their biological activities; mechanisms of intracellular survival of pathogenic mycobacteria as compared to intracellular killing of non-pathogenic mycobacteria; and pathogenesis of mycobacterial infection. The future prospects in the elucidation of the mechanisms of pathogenicity and their possible application for a better control of mycobacterial diseases are briefly discussed.
Rastogi
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Unité de la Tuberculose et des Mycobactéries, Institut Pasteur, Paris, France.
David
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HL
D000818:Animals; D002462:Cell Membrane / Q000032:analysis; D003311:Cord Factors / Q000032:analysis / Q000633:toxicity; D006017:Glycolipids / Q000032:analysis / Q000633:toxicity; D006801:Humans; D008055:Lipids / Q000032:analysis / Q000633:toxicity; D009161:Mycobacterium / Q000472:pathogenicity* / Q000648:ultrastructure; D009164:Mycobacterium Infections / Q000382:microbiology; D010586:Phagocytes / Q000276:immunology; D014774:Virulence
D003311:Cord Factors; D006017:Glycolipids; D008055:Lipids; C015518:sulfolipids