title: Poststreptococcal glomerulonephritis in children: clinicopathological correlations and long-term prognosis.
abstract: Between 1962 and 1970, 36 children with acute biopsy-proven poststreptococcal glomerulonephritis (PSGN) entered a prospective long-term follow-up study. The initial biopsies were scored into four histological grades using criteria based on endocapillary proliferation, leucocyte infiltration, epithelial "hump" and crescent formation; 5 patients had grade-1 (least severe), 14 grade-2, 15 grade-3 and 2 grade-4 biopsies. Two children died from rapidly progressive glomerulonephritis; both had grade-4 biopsies. Early repeat biopsy in 12 patients showed improvement in all but one patient who progressed from grade 2 to type 2 mesangiocapillary glomerulonephritis (MCGN). The initial biopsy grade correlated significantly with heavy proteinuria (chi2 = 9.73, P less than 0.01) but not with hypertension, haematuria or renal functional impairment. Follow-up observations were made after mean periods of 9.5 years (range 5.4-12.4 years; 32 subjects) and 19.0 years (range 14.6-22 years; 30 subjects). None of the survivors had an abnormal plasma creatinine. Only one patient (grade-3 biopsy), a female with a subsequent history of recurrent pyelonephritis, was hypertensive. Isolated microscopic haematuria persisted in 1 grade-2 and 2 grade-3 subjects. One grade-2 subject had proteinuria secondary to MCGN and one grade-3 subject had mild proteinuria and borderline hypertension. Although 20% of subjects had urinary abnormalities, we conclude that the long-term outcome of PSGN in children is excellent.
authors.affiliation: Evelina Children's Department, Guy's Hospital, London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Clark
authors.forename: R H
authors.initials: RH
authors.lastname: White
authors.forename: E F
authors.initials: EF
authors.lastname: Glasgow
authors.forename: C
authors.initials: C
authors.lastname: Chantler
authors.forename: J S
authors.initials: JS
authors.lastname: Cameron
authors.forename: D
authors.initials: D
authors.lastname: Gill
authors.forename: L A
authors.initials: LA
authors.lastname: Comley
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology; D008297:Male; D011379:Prognosis; D013290:Streptococcal Infections / Q000150:complications*; D013997:Time Factors