title: Spontaneous activity of type II but not type I striatal neurons is correlated with recovery of behavioral function after dopamine-depleting brain lesions.
abstract: The relation between the spontaneous firing of Type I striatal neurons and recovery of behavioral function after near-total dopamine depletions of the rat striatum was investigated. The results demonstrate that the activity of Type I neurons remains elevated in recovered animals, which contrasts with our previous finding that the firing rates of Type II striatal neurons return to normal levels in association with behavioral recovery.
authors.affiliation: Department of Behavioral Neuroscience, University of Pittsburgh, PA 15260.
authors.forename: E S
authors.initials: ES
authors.lastname: Nisenbaum
authors.forename: E M
authors.initials: EM
authors.lastname: Stricker
authors.forename: M J
authors.initials: MJ
authors.lastname: Zigmond
authors.forename: T W
authors.initials: TW
authors.lastname: Berger
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D018492:Dopamine Antagonists; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
chemical_list: D018492:Dopamine Antagonists; D006892:Hydroxydopamines; D016627:Oxidopamine; D004298:Dopamine