title: The influence of extracellular calcium on the distribution of protein kinase C in non-neoplastic and neoplastic rat liver cells.
abstract: Non-neoplastic T51B rat liver epithelial cells cannot proliferate in Ca2+-deficient medium. This proliferative inhibition in Ca2+-deficient medium is accompanied by a large reduction in the amount of cellular EDTA-extractable Ca2+/phospholipid-dependent protein kinase (protein kinase C) activity. By contrast, tumorigenic epithelial cells from several Morris hepatomas proliferate in Ca2+-deficient medium and either maintain or greatly increase their content of EDTA-extractable protein kinase C.
authors.forename: D
authors.initials: D
authors.lastname: Bossi
authors.forename: J F
authors.initials: JF
authors.lastname: Whitfield
authors.forename: A L
authors.initials: AL
authors.lastname: Boynton
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D002455:Cell Division; D004492:Edetic Acid / Q000494:pharmacology; D005110:Extracellular Space / Q000032:analysis*; D008099:Liver / Q000201:enzymology*; D008114:Liver Neoplasms, Experimental / Q000201:enzymology*; D011493:Protein Kinase C; D011494:Protein Kinases / Q000032:analysis*; D051381:Rats
chemical_list: D004492:Edetic Acid; D011494:Protein Kinases; D011493:Protein Kinase C; D002118:Calcium