Effects of fenfluramine, m-chlorophenylpiperazine, and other serotonin-related agonists and antagonists on penile erections in nonhuman primates.
Fenfluramine, m-chlorophenylpiperazine (m-CPP), 1-phenylpiperazine, and the buspirone metabolite, 1-(2-pyrimidyl)piperazine given intravenously to adult rhesus monkeys regularly elicited penile erections. In contrast, serotonin (5-HT) agonists with 5-HT1A site specificity (8-OH-DPAT, buspirone) as well as trazodone, ritanserin, and metergoline were no different from saline in producing penile erections. Fenfluramine's effects were blocked by the 5-HT2 antagonists, ritanserin and metergoline, while m-CPP's effects were not blocked by the peripheral 5-HT antagonist, xylamidine, indicating that tumescence can be elicited by serotonergic agents which act at non-5-HT1A sites in the central nervous system.
Szele
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Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892.
Murphy
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DL
Garrick
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NA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005277:Fenfluramine / Q000494:pharmacology*; D008251:Macaca / Q000502:physiology*; D008253:Macaca mulatta / Q000502:physiology*; D008297:Male; D010410:Penile Erection / Q000187:drug effects*; D010879:Piperazines / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*
D010879:Piperazines; D011985:Receptors, Serotonin; D005277:Fenfluramine; C015068:1-(3-chlorophenyl)piperazine