Effects of three histaminergic compounds on function and oxygen consumption of isolated guinea-pig hearts.
First experiences in man indicate, that even in catecholamine-insensitive congestive cardiomyopathy a considerable improvement of myocardial function can be attained by the H2-receptor agonist impromidine. In an isolated, pressure-volume work performing guinea-pig heart preparation cardiac effects of three histaminergic compounds (Na,5-dimethylhistamine (HC1)2, 5-ethyl-Na-methyl-histamine (HC1)2, Na,Na-dimethyl-histamine (HC1)2) were examined. Influences on function and myocardial oxygen consumption were compared to those obtained by impromidine. Dose-response curves for the histamine derivatives were 1.7-2.5 orders of magnitude right of the impromidine curves. Maximal inotropic stimulation was greater for Na,5-dimethyl-histamine (HC1)2 than for impromidine. All compounds exhibited a high chronotropic effect and, at high concentrations, a net coronary dilating effect.
Permanetter
B
B
Baumann
G
G
Dörner
J
J
Schunack
W
W
Blömer
H
H
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology; D017446:Impromidine; D066298:In Vitro Techniques; D008761:Methylhistamines / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D011968:Receptors, Histamine / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*
D007093:Imidazoles; D008761:Methylhistamines; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D017446:Impromidine