title: Immunohistochemical analysis of cells in mucosal lesions of oral lichen planus.
abstract: We immunohistochemically analyzed the immunological background of the pathogenesis of oral lichen planus (OLP). Abundant lymphocytes infiltrated OLP mucosal lesions, particularly in satellite cell necrosis (SCN) regions, and cytotoxic/suppressor T lymphocytes were predominant in seven of 10 OLP cases. Some carried IL-2 receptors, particularly in SCN. Keratinocytes of the mucosal lesions expressed both HLA-ABC and HLA-DR antigens. This suggests that activated cytotoxic/suppressor T lymphocytes may play a major role in cytotoxicity to keratinocytes as effector cells in OLP. OKM1-, OKM5+, HLA-DR+ and IL-1+ cells, vascular endothelial cells and clusters of spindle-shaped or oval cells, which had the same surface characteristics as a monocyte macrophage subset, were abundant and, together with migrating lymphocytes, might play a role in the immune response in mucosal lesions of OLP.
authors.affiliation: Department of Oral Surgery, Nagoya University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: I
authors.initials: I
authors.lastname: Tohnai
authors.forename: T
authors.initials: T
authors.lastname: Kaneda
authors.forename: H
authors.initials: H
authors.lastname: Nagura
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D005260:Female; D005882:Gingival Diseases / Q000473:pathology; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007963:Leukocytes, Mononuclear / Q000473:pathology; D008010:Lichen Planus / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology; D014060:Tongue Diseases / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens