Reduction in morphological sickling of red cells incubated with quinine.
Quinine HCl reduced the formation of reversibly sickled cells in vitro over a concentration range of 0.2-5.0 mM. Quinidine and chloroquine had similar effects. Combinations of quinine and cyanate demonstrated synergistic, antisickling properties in vitro.
Mankad
V N
VN
Department of Pediatrics, University of South Alabama College of Medicine, Mobile 36617.
Moore
R B
RB
D000755:Anemia, Sickle Cell / Q000097:blood* / Q000473:pathology; D002738:Chloroquine / Q000494:pharmacology; D003485:Cyanates / Q000494:pharmacology; D004357:Drug Synergism; D004913:Erythrocytes, Abnormal / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D011803:Quinine / Q000494:pharmacology*
D003485:Cyanates; D002738:Chloroquine; D011803:Quinine