Neutrophil phagocytosis in sarcoidosis. Reduced C3b receptor-mediated phagocytosis in active and silent sarcoidosis.
The phagocytic and complement receptor function of polymorphonuclear neutrophils (PMN) from patients with sarcoidosis was studied using a kinetic assay which allows the distinction to be made between Fc receptor-mediated and C3b receptor-mediated particle uptake. The study included one group (A) of patients with active disease (n = 20), and one group (B) with silent or inactive disease who since 10 years had no symptoms or radiological signs of sarcoidosis (n = 11). Abnormal C3b receptor function was observed in both groups but the impairment was most pronounced in the A group. The presence of C3b receptor dysfunction in both groups with a quantitative difference between the groups, is compatible with C3b receptor dysfunction being a primary causal factor of sarcoidosis.
Schmekel
B
B
Håkansson
L
L
Hällgren
R
R
Nou
E
E
Stålenheim
G
G
Venge
P
P
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008170:Lung Compliance; D008171:Lung Diseases / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000097:blood; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D011951:Receptors, Complement / Q000032:analysis*; D017463:Receptors, Complement 3b; D012129:Respiratory Function Tests; D012507:Sarcoidosis / Q000201:enzymology / Q000276:immunology* / Q000503:physiopathology
D007074:Immunoglobulin G; D011951:Receptors, Complement; D017463:Receptors, Complement 3b; D009113:Muramidase