title: Arteriography and histopathology in experimentally produced atherosclerosis in rhesus and fascicularis monkeys.
abstract: In order to attempt to characterize atheromatous plaque dynamics, and to develop standardized techniques of observation of this behavior, 91 arteriographies were performed on 47 subhuman primates (40 Rhesus and 7 Fascicularis) over a 10-year experimental project. Histopathologic examination was performed at biopsy on the majority of animals and at autopsy on all animals. Selected representative arteriograms and histopathologic cross-sections are presented as well as detailed analyses of the various animals' response to atherogenic regimen. Arteriographic stenosis was site specific for 4 sites virtually exclusively: right internal carotid, inferior mesenteric, lumbar, and presacral arteries. There was no distinction within each grade of stenosis (on a 1-4 grade scale) for all arteriograms, and precision reproducibility of arteriographic technique was achieved without regard to age, size, weight, or type of animal. The consistency and exclusivity of arteriographic 4-site pattern of stenosis, together with non-correlation between it and the histopathologic or surgical observations, suggests that the stenosis observed by all of these methods may be partially or completely a function of artefact attributable to technique. At the very minimum, arteriographic and histopathologic methods are demonstrably dissociative and, therefore, the findings of these 2 cannot be compared in grading atherosclerotic plaque advancement or regression.
authors.affiliation: Department of Radiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
authors.forename: E M
authors.initials: EM
authors.lastname: Bellon
authors.forename: J D
authors.initials: JD
authors.lastname: Reid
mesh_terms: D000792:Angiography / Q000379:methods; D000818:Animals; D001011:Aorta / Q000473:pathology; D001013:Aorta, Thoracic / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology*; D001916:Brachial Artery / Q000473:pathology; D002339:Carotid Arteries / Q000473:pathology; D002406:Catheterization, Peripheral; D002784:Cholesterol / Q000097:blood; D005263:Femoral Artery / Q000473:pathology; D008252:Macaca fascicularis; D008253:Macaca mulatta; D013997:Time Factors
chemical_list: D002784:Cholesterol