title: Immunoregulation in human schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms.
abstract: Anti-idiotypic (anti-Id) T cells from schistosomiasis patients or former patients proliferate upon exposure to polyclonal or monoclonal anti-soluble egg antigen (SEA) antibodies. Chloroquine does not inhibit, the response, which is induced by F(ab')2 (but not soluble Fab) fragments of these antibodies. Purified T cells from former patients require macrophages or exogenous IL-1 to respond to anti-SEA Ids and can respond to matrix-bound Fab fragments in the presence of IL-1. These anti-Id T cells recognize the Ids directly. Chronic schistosomiasis patients immunoregulate the production of a non-IL-2 lymphokine that stimulates IL-2 receptor expression on resting T cells. This regulation is reversed upon chemotherapeutic cure.
authors.affiliation: VA Medical Center, Vanderbilt Univ., Nashville, TN.
authors.forename: D G
authors.initials: DG
authors.lastname: Colley
authors.forename: J C
authors.initials: JC
authors.lastname: Parra
authors.forename: M A
authors.initials: MA
authors.lastname: Montesano
authors.forename: M
authors.initials: M
authors.lastname: Lima
authors.forename: E
authors.initials: E
authors.lastname: Nascimento
authors.forename: B L
authors.initials: BL
authors.lastname: Doughty
authors.forename: A
authors.initials: A
authors.lastname: Goes
authors.forename: G
authors.initials: G
authors.lastname: Gazzinelli
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D000947:Antigens, Helminth / Q000276:immunology*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D007375:Interleukin-1 / Q000494:pharmacology; D008222:Lymphokines / Q000276:immunology; D010063:Ovum / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000909:Antibodies, Helminth; D000911:Antibodies, Monoclonal; D000947:Antigens, Helminth; D007140:Immunoglobulin Fab Fragments; D007130:Immunoglobulin Idiotypes; D007375:Interleukin-1; D008222:Lymphokines; D015375:Receptors, Interleukin-2