Microbial spectrum of blood and body cultures in febrile episodes of children under chemotherapy for treatment of malignant diseases.
One hundred thirty-five febrile episodes in 111 children with malignancies were reviewed. In 50 of 125 episodes blood cultures were positive; gram-positive bacteremia was detected in 40 episodes and gram-negative bacteremia in 10 episodes. The predominant gram-positive bacteria were coagulase-negative staphylococci, the predominant gram-negative bacteria were Escherichia coli. The possible role of coagulase-negative staphylococci in causing septicemia in immunocompromised hosts is discussed with conclusions that influence designing a primary antibiotic regimen to treat febrile episodes in leukopenic children.
Göbel
V
V
Universitäts-Kinderklinik Düsseldorf, Abteilung für Hämatologie und Onkologie, F.R.G.
Jürgens
H
H
Thomas
L
L
Schwamborn
D
D
Rosin
H
H
Göbel
U
U
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001419:Bacteria / Q000302:isolation & purification*; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D001769:Blood / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D004755:Enterobacteriaceae / Q000302:isolation & purification; D005334:Fever / Q000150:complications / Q000382:microbiology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D007223:Infant; D009369:Neoplasms / Q000150:complications* / Q000382:microbiology; D018805:Sepsis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000302:isolation & purification
D000900:Anti-Bacterial Agents