title: Inhibition of mouse liver alcohol dehydrogenase by methyl N-butyl ketone.
abstract: Methyl N-butyl ketone (MNBK) inhibited the activity of mouse liver alcohol dehydrogenase (LADH) in vitro. Ethanol elimination was reduced in MNBK-treated mice as compared to controls. Ethanol-induced induced loss of righting reflex was significantly prolonged in mice pretreated with MNBK.
authors.forename: M
authors.initials: M
authors.lastname: Sharkawi
authors.forename: B
authors.initials: B
authors.lastname: Elfassy
mesh_terms: D000426:Alcohol Dehydrogenase; D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002849:Chromatography, Gas; D000431:Ethanol / Q000097:blood / Q000378:metabolism; D066298:In Vitro Techniques; D007659:Ketones / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008742:Methyl n-Butyl Ketone / Q000494:pharmacology*; D051379:Mice; D013997:Time Factors
chemical_list: D007659:Ketones; D000431:Ethanol; D008742:Methyl n-Butyl Ketone; D000429:Alcohol Oxidoreductases; D000426:Alcohol Dehydrogenase