Hyponatremia and renal sodium wasting in patients receiving cisplatinum.
Three children with malignant solid tumors developed hyponatremia with renal sodium wasting associated with other signs of tubular dysfunction, such as hypokalemia or hypomagnesemia, a few days after cis-diammine dichloroplatinum (CDDP) administration. The normalization of serum electrolyte disturbances was obtained with increased parenteral intakes in fluids and electrolytes, and renal sodium wasting stopped by itself a few days later.
Vassal
G
G
Institut Gustave Roussy, Villejuif, France.
Rubie
H
H
Kalifa
C
C
Hartmann
O
O
Lemerle
J
J
D000293:Adolescent; D001859:Bone Neoplasms / Q000150:complications / Q000188:drug therapy; D002648:Child; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced* / Q000175:diagnosis; D007085:Ilium; D007177:Inappropriate ADH Syndrome / Q000175:diagnosis; D007223:Infant; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009447:Neuroblastoma / Q000150:complications / Q000188:drug therapy; D012512:Sarcoma, Ewing / Q000150:complications / Q000188:drug therapy; D012964:Sodium / Q000378:metabolism; D013899:Thoracic Neoplasms / Q000150:complications / Q000188:drug therapy
D012964:Sodium; D002945:Cisplatin