title: Controlled release of diphosphonates from synthetic polymers to inhibit calcification.
abstract: Calcification is the most frequent cause of the failure of bioprosthetic heart valves fabricated from glutaraldehyde pretreated porcine aortic valves or bovine pericardium. Formulation and evaluation of controlled-release drug delivery system to inhibit bioprosthetic heart valve calcification is reviewed.
authors.affiliation: Department of Pharmacy, School of Pharmacy, Hebrew University of Jerusalem, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Golomb
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D002114:Calcinosis / Q000517:prevention & control*; D004164:Diphosphonates; D012968:Etidronic Acid; D006350:Heart Valve Prosthesis; D008297:Male; D008422:Materials Testing / Q000379:methods*; D011474:Prosthesis Design; D011475:Prosthesis Failure; D051381:Rats; D011919:Rats, Inbred Strains; D013499:Surface Properties
chemical_list: D004164:Diphosphonates; D012968:Etidronic Acid