Role of eicosanoids in inflammatory reactions of rats.
Nonsteroidal antiinflammatory agents of several subgroups, regarding eicosanoid-producing enzyme inhibition, have been tested in vitro and in vivo. There was no overt correlation between cyclooxygenase and/or lipoxygenase inhibition in vitro and antiinflammatory effects. It is possible that eicosanoids do not play a key role as inflammatory mediators, i.e. that the course of the life-protecting inflammatory reaction is ensured by an ensemble of mediators, cellular events and further mechanisms of the whole living organism.
Hirschelmann
R
R
Wissenschaftsbereich Pharmakologie, Martin-Luther-Universität Halle-Wittenberg, DDR.
Zarnack
S
S
Funke
T
T
Schmidt
K
K
Bekemeier
H
H
Giessler
A J
AJ
Ulbricht
H
H
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D016861:Cyclooxygenase Inhibitors; D004487:Edema / Q000188:drug therapy; D005260:Female; D007249:Inflammation / Q000188:drug therapy*; D016859:Lipoxygenase Inhibitors; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors