title: Pregnancy in women with primary focal and segmental hyalinosis and sclerosis.
abstract: Thirty-one pregnancies and post partum clinical course of 21 women with a diagnosis of primary focal and segmental hyalinosis and sclerosis have been analyzed. Forty-five percent (14) of pregnancies resulted in fetal loss, 39% (12) in premature delivery and 16% (5) in a term infant. Of 17 fetuses for whom birthweight was recorded, 29% (5) were small for gestational age. Maternal renal function deteriorated in 49% (15) of pregnancies, in 13% (4) irreversibly. Three of these patients (15%) subsequently progressed to end-stage renal failure, and one to progressive chronic renal impairment, by the end of follow-up (median 4 years, range 1-25 years). In 74% (23) of pregnancies hypertension was recorded and this frequently developed early (61%) and was severe (45%). Nephrotic range proteinuria developed in 42% (13) of pregnancies. Increased proteinuria was recorded in 22 (17%) pregnancies. It is concluded that pregnancy in women with primary focal and segmental hyalinosis and sclerosis is associated with increased fetal loss and maternal complications.
authors.affiliation: Department of Nephrology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
authors.forename: D K
authors.initials: DK
authors.lastname: Packham
authors.forename: R A
authors.initials: RA
authors.lastname: North
authors.forename: K F
authors.initials: KF
authors.lastname: Fairley
authors.forename: B U
authors.initials: BU
authors.lastname: Ihle
authors.forename: J A
authors.initials: JA
authors.lastname: Whitworth
authors.forename: P
authors.initials: P
authors.lastname: Kincaid-Smith
mesh_terms: D000328:Adult; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005500:Follow-Up Studies; D005921:Glomerulonephritis; D005923:Glomerulosclerosis, Focal Segmental; D006801:Humans; D006973:Hypertension; D007231:Infant, Newborn; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D007676:Kidney Failure, Chronic / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications; D011249:Pregnancy Complications, Cardiovascular; D011256:Pregnancy Outcome; D011507:Proteinuria / Q000209:etiology