title: [Acute primary phase as an indicator of HIV-1 infection. The general symptoms and polymorphic exanthema with mouth mucosal involvement 2 to 6 weeks before seroconversion].
abstract: The initial symptoms of an HIV-1 infection were observed in four patients. The following were characteristic for the acute primary phase: (a) initial maculopapular exanthema, especially of the trunk, with occasional transition into a papulovesical appearance; (b) involvement of the oral mucosa, often of aphthous character; and (c) general malaise with fever and lymphadenopathy. The observed cutaneous changes had, on one hand, features of a Coxsackie or mononucleosis exanthema, on the other of secondary syphilis. In three patients seroconversion occurred within 2-6 weeks, the fourth failed to return for follow-up. The listed acute primary symptoms can be used as the earliest indicators of an HIV-1 infection having occurred.
authors.affiliation: Universitäts-Hautklinik und Poliklinik, Klinikum Steglitz, Freie Universität Berlin.
authors.forename: B
authors.initials: B
authors.lastname: Bratzke
authors.forename: R
authors.initials: R
authors.lastname: Eichhorn
authors.forename: G
authors.initials: G
authors.lastname: Höffken
authors.forename: C
authors.initials: C
authors.lastname: Bratzke
authors.forename: R
authors.initials: R
authors.lastname: Stadler
authors.forename: G
authors.initials: G
authors.lastname: Ehlers
authors.forename: C E
authors.initials: CE
authors.lastname: Orfanos
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000473:pathology; D000208:Acute Disease; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D005076:Exanthema / Q000175:diagnosis* / Q000473:pathology; D015483:HIV Antibodies; D006679:HIV Seropositivity / Q000175:diagnosis*; D006716:Homosexuality; D006801:Humans; D008297:Male; D009059:Mouth Diseases / Q000175:diagnosis* / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral; D015483:HIV Antibodies
vernacular_title: Akute Primärphase als Indikator der HIV-1-Infektion. Allgemeine Symptomatik und polymorphes Exanthem mit Mundschleimhautbeteiligung 2-6 Wochen vor der Serokonversion.