Induction of ovulation--past, present and future.
Attempts to induce ovulation have been made since the early 1920s, but the major breakthrough came in the early 1960s with the introduction of clomiphene citrate and the gonadotropins. Additional progress was made in the early 1970s with the introduction of bromocriptine and in the early 1980s with the introduction of pulsatile GnRH. At the present, 'pure' FSH and GnRH agonists are being evaluated as adjuncts to HMG for induction of ovulation. As more insight is gained in the neuroendocrine control of the ovulating cycle, we may soon be able to induce ovulation by direct manipulation of the central nervous system.
Jewelewicz
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Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, N.Y.
Gindoff
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PR
D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D002996:Clomiphene / Q000008:administration & dosage; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008596:Menotropins / Q000008:administration & dosage; D010053:Ovary / Q000601:surgery; D010062:Ovulation Induction / Q000379:methods*; D010906:Pituitary Hormone-Releasing Hormones / Q000008:administration & dosage; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple
D006063:Chorionic Gonadotropin; D005938:Glucocorticoids; D010906:Pituitary Hormone-Releasing Hormones; D002996:Clomiphene; D008596:Menotropins