Efficacy of pefloxacin-fosfomycin in experimental endocarditis caused by methicillin-resistant Staphylococcus aureus.
The efficacies of pefloxacin, fosfomycin, and both of these agents in combination against methicillin-resistant Staphylococcus aureus were assessed in a rat endocarditis model. The combination prevented emergence of the fosfomycin and pefloxacin resistance seen in 36 and 4%, respectively, of animals receiving either agent alone and was more effective than either agent in sterilizing cardiac vegetations.
Thauvin
C
C
Department of Bacteriology, Centre Hospitalier Universitaire de Rouen, Institut National de la Santé et de la Recherche Médicale, France.
Lemeland
J F
JF
Humbert
G
G
Fillastre
J P
JP
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D005578:Fosfomycin / Q000627:therapeutic use*; D008297:Male; D008712:Methicillin / Q000494:pharmacology*; D009643:Norfloxacin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015366:Pefloxacin; D010403:Penicillin Resistance; D051381:Rats; D011919:Rats, Inbred Strains; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology
D000890:Anti-Infective Agents; D015366:Pefloxacin; D005578:Fosfomycin; D009643:Norfloxacin; D008712:Methicillin