title: Pathogenesis of limb and facial malformations induced by pyrimethamine in the rat.
abstract: The temporal sequence of morphological events resulting in limb and face malformations was studied in pyrimethamine (PY) treated female rats, 30 mg/kg of PY in a 10 ml/kg suspension of 0.9% NaCl were administered i.p. on days 12, 13 and 14 of gestation. Controls received only 0.9% NaCl solution. The females were killed at different stages of gestation (between 14 and 21 days). Early PY treated embryos showed mainly haematomas in the extremities and the mandibulo-maxillary areas. During the course of gestation, fewer haematomas and more malformations were observed. At term, malformations were observed in the same localisations where haematomas were previously seen.
authors.affiliation: Laboratory of Physiopathology of Development, University Pierre et Marie Curie, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Horvath
authors.forename: A M
authors.initials: AM
authors.lastname: Tangapregassom
authors.forename: M J
authors.initials: MJ
authors.lastname: Tangapregassom
authors.forename: M
authors.initials: M
authors.lastname: Trecul
authors.forename: M
authors.initials: M
authors.lastname: Boucher-Ehrensperger
authors.forename: A
authors.initials: A
authors.lastname: Compagnon
authors.forename: C
authors.initials: C
authors.lastname: Petter
mesh_terms: D000818:Animals; D005145:Face / Q000002:abnormalities*; D005147:Facial Bones / Q000002:abnormalities*; D005260:Female; D006406:Hematoma / Q000139:chemically induced / Q000196:embryology; D017880:Limb Deformities, Congenital; D011247:Pregnancy; D011739:Pyrimethamine / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013723:Teratogens
chemical_list: D013723:Teratogens; D011739:Pyrimethamine