Hepatitis D virus and human immunodeficiency virus antibodies in parenteral drug abusers who are hepatitis B surface antigen positive.
We studied unselected, hepatitis B surface antigen (HBsAg)-positive parenteral drug abusers for antibody to hepatitis D virus (anti-HD) and antibody to human immunodeficiency virus (HIV). The prevalences of anti-HD and antibody to HIV were 67% and 58%, respectively, and there was no association between positivity for these two markers. In a logistic regression model, anti-HD was associated with older age (P = .001), longer duration of drug abuse (P = .045), and the presence of liver disease (P = .002). Antibody to HIV was associated with a younger age (P = .003) and increased serum globulin levels (P less than .001). In patients infected with HIV, the severity of hepatic dysfunction remained correlated with anti-HD. In anti-HD-positive patients, most indices of hepatic dysfunction were similar whether or not antibody to HIV was present, but serum aspartate aminotransferase levels were significantly higher in patients with both anti-HD and antibody to HIV. (124 +/- 16 vs. 74 +/- 11, P less than .05).
Novick
D M
DM
Department of Medicine, Beth Israel Medical Center, New York, New York 10003.
Farci
P
P
Croxson
T S
TS
Taylor
M B
MB
Schneebaum
C W
CW
Lai
M E
ME
Bach
N
N
Senie
R T
RT
Gelb
A M
AM
Kreek
M J
MJ
D000386:AIDS-Related Complex / Q000150:complications; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000032:analysis*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015483:HIV Antibodies / Q000032:analysis*; D006509:Hepatitis B / Q000150:complications*; D006514:Hepatitis B Surface Antigens; D006515:Hepatitis B virus / Q000235:genetics; D003699:Hepatitis D / Q000150:complications; D003698:Hepatitis Delta Virus / Q000276:immunology*; D006801:Humans; D008297:Male; D009519:New York City; D012044:Regression Analysis; D019966:Substance-Related Disorders / Q000150:complications*
D000914:Antibodies, Viral; D004279:DNA, Viral; D015483:HIV Antibodies; D006514:Hepatitis B Surface Antigens