title: [Reaction of poly(ADP)-ribosylation of histone H1 in the presence of P1,P4-bis(5'-adenosyl)tetraphosphate and its phosphonate analogs].
abstract: Effects of P1,P4-bis(5'-adenosyl)tetraphosphate and its phosphonate analogs on the ADP-ribosylation of H1 catalyzed by bovine testis ADP-ribose polymerase was investigated. Analogs App[CH(COCH3)]ppA and Ap[CH2]pppA as well as Ap4A inhibited poly(ADP)-ribosylation of histone H1 and at the same time accepted the ADP-ribosyl moiety of NAD. It was shown that inhibition of ADP-ribosylation of histone H1 is due to the competition of nucleotides with histone H1 for accepting ADP-ribosyl moiety of NAD on the one hand, and alteration of acceptor properties of the histone H1 on the other.
authors.forename: L V
authors.initials: LV
authors.lastname: Karabashian
authors.forename: D L
authors.initials: DL
authors.lastname: Arutiunian
authors.forename: N B
authors.initials: NB
authors.lastname: Tarusova
authors.forename: T V
authors.initials: TV
authors.lastname: Tyrtysh
mesh_terms: D000818:Animals; D002417:Cattle; D015226:Dinucleoside Phosphates / Q000494:pharmacology*; D006657:Histones / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D009702:Nucleoside Diphosphate Sugars / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*
chemical_list: D015226:Dinucleoside Phosphates; D006657:Histones; D009702:Nucleoside Diphosphate Sugars; D009943:Organophosphorus Compounds; D011064:Poly Adenosine Diphosphate Ribose; C020733:diadenosine tetraphosphate; D011065:Poly(ADP-ribose) Polymerases
vernacular_title: Izuchenie reaktsii poli(ADP)-ribozilirovaniia gistona H1 v prisutstvii P1,P4-bis(5'-adenozil)tetrafosfata i ego fosfonatnykh analogov.