[Effects of keto-analogs of essential amino acids with or without associated protein restriction on the phospho-calcium metabolism of hemodialysed patients: a randomized prospective crossover study].
The short term effects of a low (RP: 0.4 g/kg/day) and a normal (RN: 1 g/kg/day) protein diet supplemented by calcium salts of keto-analogs (CA) (200 mg/kg/day) were observed in a crossover study of phosphocalcic metabolism in 15 chronic dialysed patients during 15 days using a crossover device. CA were well tolerated but CA.RP was accompanied by a caloric diminution of 12% (p = 0.001) and albumin reduction of 5% (p = 0.004). Blood urea nitrogen was reduced by 32% (p = 0.001) with CA.RP. Blood creatinine was not modified by CA.RP or CA. RN. Blood phosphorus (P) and parathormone (PTH) levels were respectively reduced by 29% (p = 0.001) and 27% (p = 0.008) with CA.RP; and by 15% (p = 0.03) and 18% (p = 0.006) with CA.RN. Calcemia was raised about 9% (p = 0.002) by both sets of treatment. There was no significant difference between the two treatments. Thus CA can reduce P and PTH without need for a restricted protein diet which may be accompanied by complications on long term utilisation.
Mahmoud
M D
MD
Service de Néphrologie-Médecine Interne, C.H. Cholet.
Bouché
V
V
Collin
P
P
D000596:Amino Acids / Q000494:pharmacology / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism*; D004044:Dietary Proteins / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007651:Keto Acids / Q000494:pharmacology / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000178:diet therapy / Q000188:drug therapy* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000378:metabolism*; D011446:Prospective Studies; D011897:Random Allocation; D006435:Renal Dialysis
D000596:Amino Acids; D004044:Dietary Proteins; D007651:Keto Acids; D010758:Phosphorus; D002118:Calcium
Effets des céto-analogues des acides aminés essentiels avec ou sans restriction protidique associée sur le métabolisme phospho-calcique des patients hémodialysés: étude prospective randomisée en essai croisé.