Myo-inositol transport through the blood-brain barrier.
The unidirectional transport of [3H]myo-inositol across cerebral capillaries, the anatomical locus of the blood-brain barrier, was measured using an in situ rat brain perfusion technique. Myo-inositol was transported across the blood-brain barrier by a low capacity, saturable system with a one-half saturation concentration of approximately 0.1 mM. The permeability surface-area product was 6.2 x 10(-5) S-1 with a myo-inositol concentration of 0.02 mM in the perfusate. The myo-inositol stereoisomer scyllo-inositol but not (+)-chiro-inositol (both 1 mM) inhibited myo-inositol transfer through the blood-brain barrier. These observations provide evidence that myo-inositol is transferred through the blood-brain barrier by simple diffusion and a stereospecific, saturable transport system.
Spector
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Department of Internal Medicine, University of Iowa, College of Medicine, Iowa City 52242.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D007294:Inositol / Q000493:pharmacokinetics*; D051381:Rats; D013237:Stereoisomerism
C009217:scyllitol; D007294:Inositol