title: Multilocus analysis of the fragile X syndrome.
abstract: A multilocus analysis of the fragile X (fra(X] syndrome was conducted with 147 families. Two proximal loci, DXS51 and F9, and two distal loci, DXS52 and DXS15, were studied. Overall, the best multipoint distances were found to be DXS51-F9, 6.9%, F9-fra(X), 22.4%; fra(X)-DXS52, 12.7%; DXS52-DXS15, 2.2%. These distances can be used for multipoint mapping of new probes, carrier testing and counseling of fra(X) families. Consistent with several previous studies, the families as a whole showed genetic heterogeneity for linkage between F9 and fra(X).
authors.affiliation: New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314.
authors.forename: W T
authors.initials: WT
authors.lastname: Brown
authors.forename: A
authors.initials: A
authors.lastname: Gross
authors.forename: C
authors.initials: C
authors.lastname: Chan
authors.forename: E C
authors.initials: EC
authors.lastname: Jenkins
authors.forename: J L
authors.initials: JL
authors.lastname: Mandel
authors.forename: I
authors.initials: I
authors.lastname: Oberlé
authors.forename: B
authors.initials: B
authors.lastname: Arveiler
authors.forename: G
authors.initials: G
authors.lastname: Novelli
authors.forename: S
authors.initials: S
authors.lastname: Thibodeau
authors.forename: R
authors.initials: R
authors.lastname: Hagerman
mesh_terms: D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D008297:Male; D010375:Pedigree; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D012984:Software
chemical_list: D005819:Genetic Markers; D004247:DNA