[One point determination of oral caffeine clearance in patients with liver diseases].
Caffeine clearance has been determined in 117 volunteers and patients (including 27 patients with liver cirrhosis) after oral application of 366.1 mg caffeine according to conventional pharmacokinetic methods (Cl = D/AUC). The resulting clearance values can be estimated with adequate accuracy from the plasma concentration at 12h for a concentration range of 2.0 to 6.5 mg/l according to Cl max = Doses/C 12h x t 12h x e and for concentrations higher than 6.5 mg/l according to Cl = Vd x (1n (D/Vd) - 1n C 12h/t 12h Vd is estimated from body weight as Vd = 0.42 x BW. "One - point" - estimation does not provide reliable data for plasma concentrations below 2.0 mg/l.
Richter
E
E
Med. Univ.-Klinik Würzburg.
Brachtel
D
D
Hofstetter
G
G
Joeres
R
R
Klinker
H
H
Junggeburth
J
J
Epping
J
J
Zilly
W
W
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002110:Caffeine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006509:Hepatitis B / Q000097:blood; D006526:Hepatitis C / Q000097:blood; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood*; D008111:Liver Function Tests; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged
D002110:Caffeine
Einpunktbestimmung der oralen Koffeinclearance bei Patienten mit Lebererkrankungen.