[Effect of 5,7-dihydroxytryptamine on pain sensitivity and analgesic activity of morphine].
Electron microscopy of rats ultrathin sections from dorsal and central raphe nucleus and spinal cord after 5,7-dihydroxytryptamine intracisternal microinjection (200 micrograms) has revealed neurones and axonal terminals distruction, which associated with tail-flick hypoalgesia and blood pressure nociceptive reactions diminished. In this condition the morphine (2 mg/kg) analgesia and drug depressive effect on pain hemodynamic manifestations increase significantly.
Ignatov
Iu D
IuD
Otellin
V A
VA
Zaĭtsev
A A
AA
Kucherenko
R P
RP
Petriaevskaia
N V
NV
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000473:pathology; D004102:Dihydroxytryptamines / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects / Q000473:pathology
D004102:Dihydroxytryptamines; D015116:5,7-Dihydroxytryptamine; D009020:Morphine
Vliianie 5,7-digidroksitriptamina na bolevuiu chuvstvitel'nost' i boleutoliaiushchee deĭstvie morfina.