title: Comparative in vitro activities of aztreonam, ciprofloxacin, norfloxacin, ofloxacin, HR 810 (a new cephalosporin), RU28965 (a new macrolide), and other agents against enteropathogens.
abstract: The in vitro activity of drugs currently used in the treatment of diarrhea against 595 enteropathogens from worldwide sources was compared with that of six newly developed antibiotics, ciprofloxacin; norfloxacin; ofloxacin; aztreonam; HR810, an expanded-spectrum cephalosporin; and RU28965, a new macrolide. In contrast with ampicillin and chloramphenicol, trimethoprim-sulfamethoxazole showed an excellent activity against all of the enteropathogens tested, except Campylobacter species. Ciprofloxacin had the highest activity, with an overall 90% MIC of less than or equal to 0.097 micrograms/ml, except for Campylobacter species (0.39 micrograms/ml). Unlike other cephalosporins, HR810 showed a satisfactory activity against Campylobacter species (90% MIC of 3.12 micrograms/ml). RU28965 was three times less active than erythromycin against Campylobacter species.
authors.forename: H
authors.initials: H
authors.lastname: Goossens
authors.forename: P
authors.initials: P
authors.lastname: De Mol
authors.forename: H
authors.initials: H
authors.lastname: Coignau
authors.forename: J
authors.initials: J
authors.lastname: Levy
authors.forename: O
authors.initials: O
authors.lastname: Grados
authors.forename: G
authors.initials: G
authors.lastname: Ghysels
authors.forename: H
authors.initials: H
authors.lastname: Innocent
authors.forename: J P
authors.initials: JP
authors.lastname: Butzler
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001398:Aztreonam; D002511:Cephalosporins / Q000494:pharmacology; D002939:Ciprofloxacin; D004755:Enterobacteriaceae / Q000187:drug effects*; D007933:Leucomycins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D009643:Norfloxacin; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D000097572:Cefpirome
chemical_list: D000900:Anti-Bacterial Agents; D001398:Aztreonam; D002511:Cephalosporins; D002939:Ciprofloxacin; D007933:Leucomycins; D009268:Nalidixic Acid; D009643:Norfloxacin; D015242:Ofloxacin; D010078:Oxazines; D011804:Quinolines; D000097572:Cefpirome