Effect of flunarizine on experimentally induced facial nerve injury.
The effect of flunarizine, a calcium antagonist, on experimentally induced facial nerve injury in guinea pigs was studied electron microscopically. In flunarizine-untreated animals, intra-axonal accumulation of cell organelles and degradation of myelin sheaths were observed. In flunarizine-treated animals, these changes were not observed, but a knob-like protrusion of myelin sheaths and a structure resembling the myelin sheath in Schwann cell cytoplasm was occasionally observed.
Takimoto
I
I
Department of Otorhinolaryngology, Aoichi Medical University, Japan.
Fujibayashi
K
K
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D005154:Facial Nerve / Q000098:blood supply* / Q000648:ultrastructure; D005158:Facial Paralysis / Q000188:drug therapy* / Q000473:pathology; D005444:Flunarizine / Q000627:therapeutic use*; D006168:Guinea Pigs; D007511:Ischemia / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000648:ultrastructure
D005444:Flunarizine