A cytophotometric and karyometric study of the cardiac muscle cells of young rats exposed to intermittent high altitude hypoxia.
Thirty-day-old rats were exposed to intermittent high altitude in barochamber (7000 m, 4 h per day, 4 exposures) and number of mono- and binucleated myocytes as well as DNA content per nucleus were determined in the right ventricular myocardium. The data indicate enhancement of mitotic division of mono- and binuclear diploid cells in hypoxic animals. Simultaneously, an increase in mononuclear and binuclear tetraploid cells occurred; the latter is probably due to DNA synthesis not followed by mitosis of some binuclear diploid cells.
Arefyeva
A M
AM
Mares
V
V
Ostádal
B
B
Brodsky
W Y
WY
D000531:Altitude; D000818:Animals; D002455:Cell Division; D002467:Cell Nucleus / Q000378:metabolism / Q000648:ultrastructure*; D004247:DNA / Q000378:metabolism; D000860:Hypoxia / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008722:Methods; D009132:Muscles / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D011003:Ploidies; D051381:Rats; D011919:Rats, Inbred Strains
D004247:DNA