Aminoglycoside and nephrotoxicity.
The effect of three aminoglycosides--gentamicin, netilmicin and amikacin--on renal acid excretion was studied in male rats treated with doses equivalent to those clinically used. The amikacin and netilmicin groups showed no important changes in the values of glomerular filtration rate (GFR), effective renal plasma flow (ERPF) and U/P inulin ratio during normal and acidotic conditions. The gentamicin group, however, showed a clear tendency to decreases in these functional parameters even in normal conditions, a finding that reinforces the concept that gentamicin is more nephrotoxic than other aminoglycosides. During normal conditions net acid excretion (BH) did not change with any of the three tested drugs. However, after an acute acid load BH markedly fell regardless of the antibiotic used. The capacity to elevate the urine-blood pCO2 was preserved after an alcaline overload, suggesting that the distal tubule was not significantly affected by aminoglycoside treatment. These data suggest that the clinical use of aminoglycosides during metabolic acidosis deserves close attention due to the possible deleterious effect that can emerge as the result of an inappropriate retention of acid loads.
Silva
V L
VL
Departamento de Fisiologia, Escola Paulista de Medicina, São Paulo, Brasil.
Gil
F Z
FZ
Nascimento
G
G
Cavanal
M F
MF
D000583:Amikacin / Q000633:toxicity*; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D002245:Carbon Dioxide / Q000097:blood; D005839:Gentamicins / Q000633:toxicity*; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000187:drug effects*; D009428:Netilmicin / Q000633:toxicity*; D051381:Rats
D001639:Bicarbonates; D005839:Gentamicins; D002245:Carbon Dioxide; D009428:Netilmicin; D000583:Amikacin