[Changes in the activity of the oxidative and hydrolytic enzymes of the animal cerebral cortex in the early periods after gamma irradiation and the use of meksamine and the synthetic analog of prostaglandin F2 alpha-estrofan].
In experiments with (CBA x C57B1/6)F1 mice it was shown that LDH activity moderately increased 5 min after exposure of the head to 200 Gy gamma radiation. After 60 min, there was a 24.4 per cent decrease in alkaline phosphatase activity and a 24.3 per cent increase in SDG activity. Injected prior to irradiation meksamine precluded the postirradiation increase in SDH and alleviated the postirradiation decrease in alkaline phosphatase.
Lyshov
V F
VF
Vasin
M V
MV
Chernov
Iu N
IuN
D008735:5-Methoxytryptamine / Q000494:pharmacology*; D000469:Alkaline Phosphatase / Q000528:radiation effects; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects*; D015237:Dinoprost; D005720:Gamma Rays; D006867:Hydrolases / Q000528:radiation effects*; D007770:L-Lactate Dehydrogenase / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010088:Oxidoreductases / Q000528:radiation effects*; D011460:Prostaglandins F / Q000494:pharmacology*; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013385:Succinate Dehydrogenase / Q000528:radiation effects; D013997:Time Factors; D014363:Tryptamines / Q000494:pharmacology*
D011460:Prostaglandins F; D011461:Prostaglandins F, Synthetic; D011837:Radiation-Protective Agents; D014363:Tryptamines; D008735:5-Methoxytryptamine; D015237:Dinoprost; D010088:Oxidoreductases; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D006867:Hydrolases; D000469:Alkaline Phosphatase
Izmenenie aktivnosti okislitel'nykh i gidroliticheskikh fermentov korygolovnogo mozga zhivotnykh v rannie sroki posle gamma-oblucheniia v usloviiakh primeneniia meksamina i sinteticheskogo analoga prostaglandina F2 al'fa-éstrofana.