Three consecutive primary malignancies in one patient during childhood.
Patients with a primary immunodeficiency syndrome have an increased risk of developing a malignancy. Lymphoreticular malignancies are the most common malignancies in these patients. Patients with ataxia telangiectasia (AT) also appear to be at a high risk for the development of nonlymphoid tumors--in particular, carcinomas of the gastrointestinal tract and central nervous system tumors. We describe a child with an immunodeficiency and slight neurological manifestations. During childhood she developed three consecutive primary malignancies.
Groot-Loonen
J J
JJ
Department of Pediatric Oncology, Emma Kinderziekenhuis, Amsterdam, The Netherlands.
Slater
R
R
Taminiau
J
J
Voûte
P A
PA
D000230:Adenocarcinoma / Q000276:immunology; D001254:Astrocytoma / Q000276:immunology; D001932:Brain Neoplasms / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000276:immunology; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D012811:Sigmoid Neoplasms / Q000276:immunology