Prostaglandin synthesis in dental cysts.
The synthesis of prostaglandins by dental squamous cell cysts was studied. Radiothinlayer-chromatography (RTLC) showed C14-labelled arachidonic acid to be converted into the prostaglandins PGE2, 6-oxo-PGF1 alpha, PGF2 alpha and PDG2. In addition, hydroxyfatty acid synthesis in excess of total prostaglandin production was observed. The substances mentioned are thought to be causally involved in the osteolytic activity of dental cysts.
Matejka
M
M
Porteder
H
H
Ulrich
W
W
Watzek
G
G
Sinzinger
H
H
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000328:Adult; D000368:Aged; D003803:Dentigerous Cyst / Q000378:metabolism*; D015237:Dinoprost; D015232:Dinoprostone; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015230:Prostaglandin D2; D011453:Prostaglandins / Q000096:biosynthesis*; D011457:Prostaglandins D / Q000096:biosynthesis; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis
D011453:Prostaglandins; D011457:Prostaglandins D; D011458:Prostaglandins E; D011460:Prostaglandins F; D015121:6-Ketoprostaglandin F1 alpha; D015237:Dinoprost; D015232:Dinoprostone; D015230:Prostaglandin D2