Age-related changes in the recovery of noradrenaline content in sympathetic fibres after reserpine treatment.
The aim of the present study was to evaluate noradrenaline recovery times in sympathetic fibres after reserpine administration by using fluorescence histochemical techniques. The spleen, the kidney, and the large intestine were examined 24 h to 15 d after reserpine treatment, in both young and aged male Sprague-Dawley rats, in order to establish not only the possible differences in recovery times of the various organs, but also if senescence can influence these times. The complete restoration of the noradrenaline content took place sooner in younger rats than in aged ones, and, within the same age-group, the recovery was quicker in the spleen and needed longer times in the large intestine, particularly in aged rats.
Paparelli
A
A
Istituto di Anatomia Umana Normale, Facoltà di Medicina e Chirurgia, Università di Pisa, Italy.
Soldani
P
P
Breschi
M C
MC
Ricciardi
M P
MP
Pellegrini
A
A
D000375:Aging; D000818:Animals; D005455:Fluorescent Antibody Technique; D007420:Intestine, Large / Q000294:innervation; D007668:Kidney / Q000294:innervation; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012110:Reserpine / Q000494:pharmacology*; D013154:Spleen / Q000294:innervation; D013564:Sympathetic Nervous System / Q000166:cytology / Q000187:drug effects / Q000254:growth & development*
D012110:Reserpine; D009638:Norepinephrine