Contact dermatitis to Alstroemeria.
A study was carried out on 50 workers in a floriculture centre to evaluate the incidence of contact dermatitis to Alstroemeria. 3 subjects gave positive reactions to aqueous and ethanolic extracts of cut flowers, stems and leaves. By column chromatography, the allergen was isolated and its chemical structure identified as 6-tuliposide A by proton magnetic resonance and carbon-13 magnetic resonance. Only 6-tuliposide A was isolated from cut flowers, and this gave positive reactions when patch tested at 0.01%; a-methylene-gamma-butyrolactone at 10(-5) (v/v) was positive in the same 3 subjects. Other lactones (gamma-methylene-gamma-butyrolactone, alantolactone, isoalantolactone) were negative at all concentrations used.
Santucci
B
B
Picardo
M
M
Iavarone
C
C
Trogolo
C
C
D000328:Adult; D000485:Allergens / Q000302:isolation & purification / Q000633:toxicity*; D002855:Chromatography, Thin Layer; D009783:Dermatitis, Occupational / Q000139:chemically induced*; D005260:Female; D006027:Glycosides / Q000302:isolation & purification / Q000633:toxicity*; D006801:Humans; D006885:Hydroxybutyrates / Q000633:toxicity*; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000633:toxicity*; D010944:Plants; D012882:Skin Tests; D012978:Sodium Oxybate / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000633:toxicity*
D000485:Allergens; D006027:Glycosides; D006885:Hydroxybutyrates; D010936:Plant Extracts; C046169:6-tuliposide A; D012978:Sodium Oxybate