Kinetics and action of N-methylthiotetrazole in volunteers and patients. Population-based clinical comparisons of antibiotics with and without this moiety.
Normal volunteers and patients were studied to determine the relative importance of NMTT and patient risk factors in the production of hypoprothrombinemia. The normal volunteers demonstrated in vivo NMTT production, but the order of magnitude (cefoperazone, moxalactam, and cefotetan in descending order) was different from the usual order of clinical risk. In patients, there was not a NMTT-concentration-versus-effect relationship. Patients who were vitamin K deficient were more sensitive to lower NMTT concentrations than those with normal vitamin K status. In surveillance studies, NMTT-containing antibiotics were nor more frequently associated with hypoprothrombinemia or bleeding than antibiotics that lack this moiety.
Schentag
J J
JJ
State University of New York, School of Pharmacy, Buffalo.
Welage
L S
LS
Williams
J S
JS
Wilton
J H
JH
Adelman
M H
MH
Rigan
D
D
Grasela
T H
TH
D001393:Azoles / Q000493:pharmacokinetics* / Q000494:pharmacology*; D002438:Cefoperazone / Q000494:pharmacology*; D015313:Cefotetan; D002511:Cephalosporins / Q000494:pharmacology; D002513:Cephamycins / Q000494:pharmacology*; D006801:Humans; D007020:Hypoprothrombinemias / Q000139:chemically induced*; D009070:Moxalactam / Q000494:pharmacology*; D011159:Population Surveillance; D012307:Risk Factors; D013777:Tetrazoles / Q000493:pharmacokinetics* / Q000494:pharmacology* / Q000633:toxicity
D001393:Azoles; D002511:Cephalosporins; D002513:Cephamycins; D013777:Tetrazoles; C038625:1-N-methyl-5-thiotetrazole; D015313:Cefotetan; D002438:Cefoperazone; D009070:Moxalactam