Antigen induces chronic idiotype suppression.
Hapten coupled to isologous gamma globulin can substitute for anti-idiotypic antibody in the induction of neonatal chronic idiotype suppression. The immunologically suppressed animals fail to express an idiotypically defined subset of anti-hapten antibodies in later life and harbor regulatory T cells that prevent the expression of this same antibody subset by B cells. Suppression ceases after several months, but memory of suppression persists and can be recalled by small doses of hapten-carrier conjugate. These data show that an antigen present in a mouse at birth is able to generate a T-cell-dependent suppressive mechanism that controls expression of antigen-specific antibodies through the recognition of antibody idiotypes. The idiotypic network is thus involved in the control of tolerance and the available antibody repertoire.
Tokuhisa
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Rajewsky
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D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D000888:Antibodies, Anti-Idiotypic; D000941:Antigens / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D007108:Immune Tolerance; D007130:Immunoglobulin Idiotypes / Q000235:genetics*; D007156:Immunologic Memory; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D007130:Immunoglobulin Idiotypes