Decreased expression of the stress protein HSP70 is an early event in murine erythroleukemic cell differentiation.
Two-dimensional protein gels were used to systematically assess changes in gene expression in Friend erythroleukemia cells after exposure to inducers of differentiation. A rapid decrease in expression of the stress protein HSP70 was observed after exposure to inducers. The kinetics of this change suggest that it may be related to the cellular events that regulate the onset of differentiation.
Hensold
J O
JO
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
Housman
D E
DE
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005622:Friend murine leukemia virus; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D007700:Kinetics; D004915:Leukemia, Erythroblastic, Acute / Q000378:metabolism / Q000473:pathology*; D007942:Leukemia, Experimental / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
D006360:Heat-Shock Proteins; D004121:Dimethyl Sulfoxide