Fibrinogen and albumin synthesis are regulated at the transcriptional level during the acute phase response.
During acute inflammation or after administration of monocytic products, an enhanced transcription of the fibrinogen polypeptide genes and a reduced transcription of the albumin gene were observed. The changes in the fibrinogen polypeptide transcriptional rate were found to precede the change in albumin gene transcription. These findings indicate that the altered synthesis of fibrinogen and albumin during inflammation are regulated at the transcriptional level and are most probably mediated by monocytic products (including interleukin-1).
Moshage
H J
HJ
Department of Medicine, St. Radboud University Hospital, Nijmegen, The Netherlands.
Kleter
B E
BE
van Pelt
J F
JF
Roelofs
H M
HM
Kleuskens
J A
JA
Yap
S H
SH
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D005340:Fibrinogen / Q000096:biosynthesis / Q000235:genetics*; D005786:Gene Expression Regulation / Q000187:drug effects; D005796:Genes / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000096:biosynthesis / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects; D014425:Turpentine / Q000633:toxicity
D012709:Serum Albumin; D005340:Fibrinogen; D014425:Turpentine