title: Comparative in vitro activity of imipenem against gram-positive and gram-negative aerobic bacteria from clinical isolates.
abstract: Imipenem is a member of a new class of beta-lactam antibiotics, carbapenems, with a very broad antibacterial spectrum. In this work we evaluated the in vitro activity of imipenem against a variety of bacterial strains isolated from clinical specimens as well as the activity of other beta-lactam antibiotics. The results obtained with 501 bacterial strains show that imipenem is active on both gram-negative and gram-positive microorganisms isolated from different infections. The in vitro inhibitory activity is greater than that of aztreonam, cefotaxime, ceftriaxone, piperacillin, amikacin, and netilmicin, against the majority of strains tested.
authors.affiliation: Institute of Medical Microbiology, University of Perugia Medical School, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Bastianini
authors.forename: T
authors.initials: T
authors.lastname: Sposini
authors.forename: A
authors.initials: A
authors.lastname: Bartoli
authors.forename: P
authors.initials: P
authors.lastname: Marconi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001424:Bacterial Infections / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D015378:Imipenem; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D015378:Imipenem