title: [Electrophoretic analysis of the characteristics of the protein composition of leukocytes from Down's syndrome patients].
abstract: Protein with a molecular mass of 53000 daltons undetectable in healthy persons was identified by electrophoresis in peripheral blood leukocytes of patients with Down's syndrome. The protein was completely extracted with 0.4 N HCl from leukocyte homogenates and was found to be identical, as regards electrophoretic mobility, to protein detected in two patients with chronic myeloblastic leukemia. The causes of discrepancy between theoretically expected and electrophoresis-revealed differences in protein composition of normal and trisomal cells.
authors.forename: V P
authors.initials: VP
authors.lastname: Paponov
authors.forename: P S
authors.initials: PS
authors.lastname: Gromov
authors.forename: L I
authors.initials: LI
authors.lastname: Kovalev
authors.forename: E G
authors.initials: EG
authors.lastname: Shcheglova
authors.forename: D M
authors.initials: DM
authors.lastname: Spitkovskiĭ
mesh_terms: D000293:Adolescent; D000328:Adult; D001797:Blood Protein Electrophoresis / Q000379:methods; D001798:Blood Proteins / Q000032:analysis*; D002648:Child; D004314:Down Syndrome / Q000097:blood*; D006801:Humans; D007962:Leukocytes / Q000032:analysis*; D008970:Molecular Weight; D013053:Spectrophotometry
chemical_list: D001798:Blood Proteins
vernacular_title: Elektroforeticheskiĭ analiz osobennosteĭ belkovogo sostava leĭkotsitov bol'nykh s sindromom Dauna.