Heterogeneity of HLA-DR2: definition of two subtypes by serological and cellular techniques.
We have used the serological and cellular (PLT) techniques to investigate the heterogeneity of HLA-DR2. The serologic studies demonstrate that DR2 can be subdivided into two specificities based on the patterns of reactivity with the Ninth Workshop serum, 9w555. These two DR2 subtypes were also recognized by cellular assay utilizing PLTs generated between HLA-DR2, DQ-identical, DP-identical or incompatible individuals. The data, therefore, suggest the existence of two alleles of DR2, DR2.1 (long) and DR2.2 (short).
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D'Souza
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Butler
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D015802:HLA-DR2 Antigen; D000949:Histocompatibility Antigens Class II / Q000145:classification* / Q000235:genetics / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology
D015802:HLA-DR2 Antigen; D000949:Histocompatibility Antigens Class II