title: Adherence of specific yogurt micro-organisms to human peripheral blood lymphocytes.
abstract: Yogurt lactic-acid-bacteria (LAB) consisting of Lactobacillus bulgaricus and Streptococcus thermophilus were evaluated for their capacity to bind to human peripheral blood lymphocytes (PBL). These micro-organisms adhere to human T lymphocytes, and bind to B lymphocytes, in high and low frequencies, respectively. In addition, a quantitative analysis of LAB binding to PBL was carried out using the same parameters previously applied to a Salmonella model. The effect of yogurt LAB on the natural anti-bacterial activity exerted by PBL was examined. Lymphocyte pretreatment with bacteria did not affect such functions. These findings are discussed in the light of the well known ability of yogurt LAB to modulate the immune response.
authors.affiliation: Clinica Malattie Infettive, Policlinico Umberto I. Università La Sapienza, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: De Simone
authors.forename: P P
authors.initials: PP
authors.lastname: Grassi
authors.forename: B
authors.initials: B
authors.lastname: Bianchi-Salvadori
authors.forename: G
authors.initials: G
authors.lastname: Miragliotta
authors.forename: R
authors.initials: R
authors.lastname: Vesely
authors.forename: E
authors.initials: E
authors.lastname: Jirillo
mesh_terms: D001402:B-Lymphocytes / Q000382:microbiology; D001422:Bacterial Adhesion; D001770:Blood Bactericidal Activity; D003611:Dairy Products; D006801:Humans; D007779:Lactobacillus acidophilus / Q000502:physiology; D007780:Lacticaseibacillus casei / Q000502:physiology; D008214:Lymphocytes / Q000145:classification / Q000276:immunology / Q000382:microbiology*; D012485:Salmonella typhi / Q000276:immunology; D013291:Streptococcus / Q000502:physiology; D013601:T-Lymphocytes / Q000145:classification / Q000382:microbiology; D015014:Yogurt