Transgenic mouse carrying a foreign gene on its Y-chromosome.
In an experiment in which a human A gamma/beta-globin construct gene was introduced into the germ line of mice by microinjection, we obtained a transgenic male mouse carrying the construct gene on its Y-chromosome. This mouse carried 13 copies of a 8.9 kb construct gene as a head-to-tail tandem array, and showed a low level of transcription of the human A gamma- and beta-globin gene in the erythroid tissues. This transgenic mouse can be a useful tool in studies of embryology and developmental genetics because it carries a specific DNA marker on only its Y-chromosome.
Tojo
H
H
Institute for Laboratory Animal Science, Toyama Medical & Pharmaceutical University, Japan.
Fukumaki
Y
Y
Ogita
Z
Z
D000818:Animals; D005796:Genes; D005819:Genetic Markers; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics*; D014998:Y Chromosome
D005819:Genetic Markers