Quantification and analysis of the glycosaminoglycans in human odontogenic cyst linings.
Glycosaminoglycans (GAG) were extracted from the connective tissue of 15 dental cysts, 2 dentigerous cysts and 7 keratocysts, and separated electrophoretically and chromatographically. Hyaluronic acid (dental, 2.38; dentigerous, 3.98; keratocyst, 3.19 micrograms uronic acid/mg lyophilized tissue) was the major GAG detected, with lesser amounts of heparin (dental, 1.70; dentigerous, 1.95; keratocyst, 1.80 micrograms uronic acid/mg lyophilized tissue) and chrondroitin-4-sulphate (dental, 1.33; dentigerous, 2.85; keratocyst, 1.37 micrograms uronic acid/mg lyophilized tissue). It is suggested that enzymic release of these GAGs allows their diffusion into the luminal fluid where they may contribute to expansile cyst growth.
Smith
G
G
Department of Oral Pathology, University of Birmingham, Dental School, England, U.K.
Smith
A J
AJ
Browne
R M
RM
D002809:Chondroitin Sulfates / Q000032:analysis; D003238:Connective Tissue / Q000032:analysis; D003803:Dentigerous Cyst / Q000032:analysis; D006025:Glycosaminoglycans / Q000032:analysis*; D006493:Heparin / Q000032:analysis; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis; D009807:Odontogenic Cysts / Q000032:analysis*; D011842:Radicular Cyst / Q000032:analysis
D006025:Glycosaminoglycans; D006820:Hyaluronic Acid; D006493:Heparin; D002809:Chondroitin Sulfates