title: Rapid ventricular filling in left ventricular hypertrophy: I. Physiologic hypertrophy.
abstract: The effects of endurance training on the diastolic properties of the left ventricle were examined by comparing left ventricular filling rates in 11 male distance runners and 12 age-matched nonathletic control subjects selected to have nearly similar heart rates at rest. Maximal oxygen consumption was 69 +/- 11 ml/kg-min for the athletes and 48 +/- 8 ml/kg X min for the control subjects (p less than 0.001). Left ventricular end-diastolic dimension, posterior wall thickness and mass were determined by echocardiography, and average left ventricular filling rate was determined with a nonimaging scintillation probe. Electrocardiographic voltage was significantly greater in the athlete group than in the control group (sums of the voltages of the S wave in lead V1 and the R wave in lead V5 were 40 +/- 10 and 26 +/- 7 mV, respectively) (p less than 0.001), whereas ejection fraction was similar in the two groups. Despite a modest degree of left ventricular hypertrophy in the athlete group compared with the control group (left ventricular mass index 127 +/- 30 and 82 +/- 13 g/m2, respectively) (p less than 0.001), the average left ventricular filling rate was similar in the two groups (2.53 +/- 0.34 versus 2.38 +/- 0.29 end-diastolic counts/s, p = NS). There was no trend for the athletes with a higher left ventricular mass to exhibit a slower filling rate. These findings demonstrate that unlike pathologic hypertrophy associated with chronic hemodynamic over-loading, physiologic left ventricular hypertrophy is not accompanied by slowed left ventricular diastolic filling.
authors.forename: C B
authors.initials: CB
authors.lastname: Granger
authors.forename: M K
authors.initials: MK
authors.lastname: Karimeddini
authors.forename: V E
authors.initials: VE
authors.lastname: Smith
authors.forename: H R
authors.initials: HR
authors.lastname: Shapiro
authors.forename: A M
authors.initials: AM
authors.lastname: Katz
authors.forename: A L
authors.initials: AL
authors.lastname: Riba
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D006332:Cardiomegaly / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D004452:Echocardiography; D004562:Electrocardiography; D005080:Exercise Test; D006801:Humans; D008297:Male; D010807:Physical Endurance; D011877:Radionuclide Imaging; D012420:Running; D013318:Stroke Volume; D013997:Time Factors