The side effect profile and safety of fluoxetine.
The side effect profile and safety of fluoxetine are reviewed. Side effects reported more frequently with fluoxetine than with tricyclic antidepressants are nausea, nervousness, and insomnia. Anticholinergic side effects are reported less often with fluoxetine. Analysis of adverse experiences leading to discontinuations suggests that this drug has very few serious side effects. There is no evidence that fluoxetine produces a flu-like syndrome or neuropathy similar to that seen with zimelidine. It does not appear to cause phospholipidosis in humans. Fluoxetine appears to have no epileptogenic potential except at extremely high doses. It is usually well tolerated in overdoses.
Wernicke
J F
JF
D000328:Adult; D017109:Akathisia, Drug-Induced; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000506:poisoning / Q000633:toxicity; D002318:Cardiovascular Diseases / Q000139:chemically induced; D002986:Clinical Trials as Topic; D003875:Drug Eruptions / Q000209:etiology; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects* / Q000506:poisoning / Q000633:toxicity; D006801:Humans; D007251:Influenza, Human / Q000139:chemically induced; D008064:Lipidoses / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D009422:Nervous System Diseases / Q000139:chemically induced; D010352:Patient Dropouts; D010743:Phospholipids; D010919:Placebos; D011437:Propylamines / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000209:etiology; D012640:Seizures / Q000139:chemically induced; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced; D013406:Suicide, Attempted; D014786:Vision Disorders / Q000139:chemically induced; D015031:Zimeldine / Q000009:adverse effects / Q000633:toxicity
D000929:Antidepressive Agents, Tricyclic; D010743:Phospholipids; D010919:Placebos; D011437:Propylamines; D005473:Fluoxetine; D015031:Zimeldine