title: In vitro activities of ofloxacin and four other new quinoline-carboxylic acids against Chlamydia trachomatis.
abstract: The in vitro activities of five new quinoline-carboxylic acids against 2 reference strains and 45 clinical isolates of Chlamydia trachomatis of genital origin were compared with the activities of minocycline and doxycycline. Ofloxacin was the third most active agent (after the two tetracyclines), followed by ciprofloxacin, NY-198, and AM-833.
authors.affiliation: Department of Microbiology, Saga Medical School, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Nagayama
authors.forename: T
authors.initials: T
authors.lastname: Nakao
authors.forename: H
authors.initials: H
authors.lastname: Taen
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000254:growth & development; D002939:Ciprofloxacin / Q000031:analogs & derivatives / Q000494:pharmacology; D004318:Doxycycline / Q000494:pharmacology; D016576:Fleroxacin; D024841:Fluoroquinolones; D008911:Minocycline / Q000494:pharmacology; D009643:Norfloxacin / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology*; D015363:Quinolones
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D002939:Ciprofloxacin; D015242:Ofloxacin; D008911:Minocycline; C053091:lomefloxacin; D009643:Norfloxacin; D004318:Doxycycline; D016576:Fleroxacin