Effect of intravenous ketanserin on plasma catecholamines and renin activity in normal volunteers.
In a placebo controlled, single blind, randomized cross over study catecholamines (CA) and renin activity (PRA) in plasma were measured in 2 female and 4 male healthy volunteers, at rest in the supine position, following a single intravenous injection of 0.15 mg/kg ketanserin (K) and placebo (P, 10 ml saline). K caused a significant increase in the area under the plasma norepinephrine (NE) time curve (AUCNE) from 13,200 to 18,100 ng X 1(-1) X min for 1 hour after the injection. The area under the plasma epinephrine (E) time curve (AUCE) was also increased but to a lesser extent; it was significantly elevated from 54 to 68 ng X 1(-1) X min for 1 minute after the injection. Dopamine (DA) and PRA did not show any significant response to ketanserin. Following the P injection, none of the four parameters showed any significant change.
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D000328:Adult; D002395:Catecholamines / Q000097:blood*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007650:Ketanserin; D008297:Male; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D012083:Renin / Q000097:blood*; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*
D002395:Catecholamines; D010880:Piperidines; D012702:Serotonin Antagonists; D007650:Ketanserin; D012083:Renin