title: Treatment of essential hypertension: changes in blood pressure, echocardiography and electrocardiography on three therapeutic regimes.
abstract: Forty-three patients with essential hypertension were randomly allocated to one of the following treatment regimes; - atenolol, atenolol and hydralazine or methyl dopa. Blood pressure fell into the normal range at 3 months and was similar in all 3 groups. Blood pressure remained controlled over the period of study. M-mode echocardiography was assessed initially, at 3, 6 and 12 months. All groups showed a fall in the measured indices towards the normal range with a significant reduction in left ventricular wall thickness at 3 months in the methyl dopa group and left ventricular mass in the atenolol group alone of 6 months. In conclusion, no one treatment regime appeared to have sustained advantages over another and none of the groups showed any deterioration on echocardiographic criteria during the study.
authors.forename: G I
authors.initials: GI
authors.lastname: Russell
authors.forename: J E
authors.initials: JE
authors.lastname: Pohl
authors.forename: J
authors.initials: J
authors.lastname: Baldwin
authors.forename: R F
authors.initials: RF
authors.lastname: Bing
authors.forename: A M
authors.initials: AM
authors.lastname: Heagerty
authors.forename: H
authors.initials: H
authors.lastname: Thurston
authors.forename: J D
authors.initials: JD
authors.lastname: Swales
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D006332:Cardiomegaly / Q000503:physiopathology; D004334:Drug Administration Schedule; D004452:Echocardiography; D004562:Electrocardiography; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008875:Middle Aged; D011897:Random Allocation; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D014665:Vasodilator Agents