title: Long-term results in childhood rhabdomyosarcoma: a retrospective study in Italy.
abstract: This paper reviews a series of 70 consecutive children with rhabdomyosarcoma (RMS) diagnosed during 1971-1978 and treated in five Italian institutions. Thirteen were classified as group I, 12 as group II, 37 as group III, and 8 as group IV according to the Intergroup RMS Study staging system. Survival was influenced by tumor extension at diagnosis, primary site, and response to therapy. The 5-year-survival rate was 92% for group I patients, 67% for group II, 44% for group III, and 0% for group IV. Thirty-four children had all therapy stopped after 12-32 months of complete remission, 7 had late recurrences, and 3 died from disease. Musculoskeletal sequelae were diagnosed in 11 children, short stature in 3, corneal opacity in 2, and cardiac failure in 1.
authors.affiliation: Dipartimento di Pediatria, Universitä di Padova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Carli
authors.forename: B
authors.initials: B
authors.lastname: De Bernardi
authors.forename: M
authors.initials: M
authors.lastname: Castello
authors.forename: E
authors.initials: E
authors.lastname: Madon
authors.forename: G
authors.initials: G
authors.lastname: Paolucci
authors.forename: L
authors.initials: L
authors.lastname: Zanesco
authors.forename: G
authors.initials: G
authors.lastname: Pastore
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D008297:Male; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000401:mortality* / Q000628:therapy; D015996:Survival Rate