Cyproheptadine stimulated prolactin release in the young turkey (Meleagris gallopavo).
Cyproheptadine (CHD) at doses of .1 to 10.0 mg/kg body weight produced a dose-related elevation in prolactin (PRL) and no change in luteinizing hormone (LH) levels. Cyproheptadine pretreatment failed to depress the quipazine (serotonin agonist)-induced PRL rise. Rather than inhibiting the serotonergic induction of PRL release in the young turkey, CHD exerted a stimulatory influence on PRL release through another mechanism.
Fehrer
S C
SC
Silsby
J L
JL
el Halawani
M E
ME
D000818:Animals; D003533:Cyproheptadine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007274:Injections, Intraperitoneal / Q000662:veterinary; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011388:Prolactin / Q000097:blood*; D011814:Quipazine / Q000031:analogs & derivatives / Q000494:pharmacology; D013268:Stimulation, Chemical; D014422:Turkeys / Q000097:blood*
D003533:Cyproheptadine; D011814:Quipazine; D011388:Prolactin; D007986:Luteinizing Hormone