[Clinico-immunological evaluation of T cells bearing IgG Fc receptors in brain tumor patients].
T cells bearing IgG Fc receptors (Tr cells) were determined in 40 cases of brain tumor using the double rosette method, and compared with the changes of PHA reaction, immunoglobulin (IgG A M), performance status, and mass effect on CT in 20 pre-and post-operative and/or radio-clinico-immunotherapeutic patients. The proportion of control Tr cells was 8-19% in 20 healthy adults. Values of Tr cells over 20% were correlated with a poor grade of performance status, and large mass effects on CT. Post-therapeutic change in the value was well correlated with change in performance status, mass effects, and IgG. Our results suggest a correlation between the value of Tr cells and clinico-radiological findings. Immunological analysis of Tr cells serves as a parameter of tumor expansion or prognosis, and could be of significant importance clinically.
Kawamoto
K
K
Kawakami
K
K
Oka
N
N
Nishimura
T
T
Ouchi
M
M
Okuyama
T
T
Miki
K
K
Kawamura
Y
Y
Matsumura
H
H
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000276:immunology*; D004407:Dysgerminoma / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007141:Immunoglobulin Fc Fragments / Q000032:analysis*; D007128:Immunoglobulin Fragments / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis; D008213:Lymphocyte Activation; D015376:Nimustine; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D010835:Phytohemagglutinins / Q000494:pharmacology; D010844:Picibanil / Q000008:administration & dosage; D017452:Receptors, IgG; D011971:Receptors, Immunologic / Q000032:analysis*; D013601:T-Lymphocytes / Q000276:immunology*
D007070:Immunoglobulin A; D007141:Immunoglobulin Fc Fragments; D007128:Immunoglobulin Fragments; D007075:Immunoglobulin M; D009607:Nitrosourea Compounds; D010835:Phytohemagglutinins; D017452:Receptors, IgG; D011971:Receptors, Immunologic; D015376:Nimustine; D010844:Picibanil