Cytogenetic effects of acrylamide in the bone marrow of mice.
A single i.p. injection of 100 mg/kg acrylamide monomer elevated the frequency of chromosome aberrations and micronucleated polychromatic erythrocytes in the bone marrow of male ICR mice. A positive relationship between frequency of micronuclei and dose of acrylamide was obtained in the dose range of 2 x 25, 2 x 50 and 2 x 100 mg/kg.
Cihák
R
R
Research Institute for Organic Syntheses, Department of Toxicology, Pardubice-Rosice, Czechoslovakia.
Vontorková
M
M
D020106:Acrylamide; D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D004913:Erythrocytes, Abnormal; D008297:Male; D051379:Mice; D015162:Micronucleus Tests
D000178:Acrylamides; D020106:Acrylamide