Changes in plasminogen activator activity and plasmin inhibition in the pig during experimental hypovolaemia.
A markedly decreased plasminogen activator activity (PAA) was seen in lung, heart and kidney after experimental hypovolemia in the pig. In 2 of 12 cases, an increased PAA was found in liver and spleen. In skeletal muscle, skin, sciatic nerve and in 10 of 12 cases in liver and spleen PAA was unchanged. A slightly increased plasmin inhibition was noted only in the lung. These changes in tissue PAA were reflected by an increase in the PAA of euglobulin fractions concomitant with a decrease in antiplasmin activity in the blood samples obtained during the bleeding experiments.
Smokovitis
A
A
Wagner
M
M
Starlinger
M
M
Opitz
A
A
Binder
B R
BR
D000818:Animals; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D005342:Fibrinolysis; D007668:Kidney / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010960:Plasminogen Activators / Q000378:metabolism*; D012769:Shock / Q000378:metabolism*; D013552:Swine; D014018:Tissue Distribution
D010960:Plasminogen Activators; D005341:Fibrinolysin