Hepatitis B virus proteins eliciting protective immunity.
The immune response to current hepatitis B vaccines appears to be qualitatively different from the response elicited during recovery from natural infection. Such disparate responses can probably be explained by the absence or under-representation of preS- and the nucleoprotein core-specific determinants in the vaccines. The incorporation of these determinants into future vaccines may improve their efficacy.
Neurath
A R
AR
New York Blood Center, New York 100021.
Jameson
B A
BA
Huima
T
T
D006509:Hepatitis B / Q000517:prevention & control; D006511:Hepatitis B Antigens; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D014614:Vaccines, Synthetic / Q000302:isolation & purification; D014761:Viral Hepatitis Vaccines / Q000302:isolation & purification*; D014764:Viral Proteins / Q000276:immunology
D006511:Hepatitis B Antigens; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines; D014764:Viral Proteins