Isolation and structure of a pseudopeptide gamma-L-glutamyl-L-aspartic acid from Datura stramonium that impairs learning retention in mice.
Datura stramonium contains a compound that impairs learning retention in mice. It has been purified to homogeneity and its structure has been established as that of a gamma-L-glutamyl-L-aspartate. The biological activity of this pseudodipeptide has been found to be identical with that of the corresponding synthetic one. It has also been compared to those of various synthetic di- and tripeptides containing L- and/or D-enantiomers of the constitutive amino acids. The results show that the activity is associated with a peptidic structure containing only one type of enantiomer.
Schmitz-Bourgeois
M
M
Laboratoire de Psychophysiologie, Strasbourg, France.
Amiri
I
I
Reinbolt
J
J
Boulanger
Y
Y
Ungerer
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D013286:Datura stramonium / Q000032:analysis*; D004151:Dipeptides / Q000302:isolation & purification* / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D051379:Mice; D010946:Plants, Medicinal; D010947:Plants, Toxic
D004151:Dipeptides; C021030:gamma-glutamylaspartic acid