[Participation of tissue basophils of the parathyroid glands in the regulation of the morphofunctional state of the organ].
By means of cytometry estimation of mitotic index and nucleo-cytoplasmic relation of parathyrocytes, parathyroid glands have been studied in 52 white rats and 28 white mice under conditions of intal inhibition (30 mg/kg of body mass twice a day intraperitoneally) of tissue basophils (TB) secretory activity. For stimulation of the glands, repeated injections of trilon B and hemiparathyroidectomy are used. The experiment lasts for 3.5 days. In the rat parathyroid glands, containing a considerable amount of TB, intal does not produce any important effect of quantitative parameters of the organ's structure in intact animals, nevertheless it prevents development of hypertrophy of the parathyrocytes in the stimulated glands, as well as makes weaker the proliferative response of the cells to hemiparathyroidectomy. In mice, their parathyroid glands containing single TB, under conditions of stimulation of the parathyroid function, intal does not produce any inhibitory effect to growth of middle size parathyrocytes. The results obtained demonstrate that the parathyroid TB actively participate in regulation of the organ's morphofunctional state, intensifying the stimulating effect of hypocalcaemia to the parathyroid parenchyma.
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D000818:Animals; D001491:Basophils / Q000187:drug effects / Q000502:physiology*; D004205:Cromolyn Sodium / Q000494:pharmacology; D008297:Male; D051379:Mice; D010280:Parathyroid Glands / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D051381:Rats
D004205:Cromolyn Sodium
Uchastie tkanevykh bazofilov okoloshchitovidnykh zhelez v reguliatsii morfofunktsional'nogo sostoiniia organa.