No cytogenetic effects of quinolone treatment in humans.
Cytogenetic effects of ciprofloxacin (500 to 2,000 mg daily) and ofloxacin (200 mg daily) were studied in lymphocytes from 31 patients treated for 1 to 10 weeks. Blood samples for cytogenetic analysis were taken before the start of treatment from all patients, after 1 week from 25 patients, and after 2, 4, 6, and 10 weeks from six patients. No chromosome-damaging effect could be demonstrated in any treatment group. The mean aberration yields for each cytogenetic parameter studied and the total number of aberrations were all normal at each sampling occasion.
Mitelman
F
F
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Kolnig
A M
AM
Strömbeck
B
B
Norrby
R
R
Kromann-Andersen
B
B
Sommer
P
P
Wadstein
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000009:adverse effects; D002869:Chromosome Aberrations; D002939:Ciprofloxacin / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin; D010078:Oxazines / Q000009:adverse effects; D011804:Quinolines / Q000009:adverse effects*
D000890:Anti-Infective Agents; D010078:Oxazines; D011804:Quinolines; D002939:Ciprofloxacin; D015242:Ofloxacin