title: The influence of monotherapy with oxprenolol and nitrendipine on ambulatory blood pressure in hypertensives.
abstract: We investigated whether beta-blockers or calcium-antagonists might be preferred in baseline antihypertensive therapy. In middle-aged male patients with essential BP readings did not differ between patients on Oxprenolol or on Nitrendipine (average BP: 123 +/- 12/81 +/- 14 vs. 129 +/- 17/80 +/- 10 mmHg), when clinical casual BP was within the normotensive range. Average BP at work was lower than clinical casual BP taken at the same day (125 +/- 14/80 +/- 12 vs. 133 +/- 12/87 +/-13 mmHg). A linear dependency between SBP at work and level of self reported physical activity (F(3,413) = 7.6; p less than or equal to 0.001) and arousal was found (F(3,374) = 5.2; p less than or equal to 0.02). Patients on Oxprenolol consistently had lower SBP at a particular level of physical activity and at lower levels of arousal than patients on Nitrendipine. We conclude that both regimen were equally effective as baseline antihypertensive monotherapy.
authors.forename: R
authors.initials: R
authors.lastname: Schmieder
authors.forename: H
authors.initials: H
authors.lastname: Rüddel
authors.forename: W
authors.initials: W
authors.lastname: Langewitz
authors.forename: J
authors.initials: J
authors.lastname: Neus
authors.forename: O
authors.initials: O
authors.lastname: Wagner
authors.forename: A W
authors.initials: AW
authors.lastname: von Eiff
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination / Q000379:methods; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009568:Nitrendipine; D010096:Oxprenolol / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D010096:Oxprenolol; D009568:Nitrendipine; D009543:Nifedipine