Adrenoceptor function in female genital tract.
The function of adrenoceptors in the female genital tract was tested estimating the uptake of 3H-noradrenaline (3H-NA) in vitro in oviductal, uterine arterial and myometrial tissue samples obtained from 74 women. The highest 3H-NA value, 64 +/- 5 ng/g, was in the oviduct (p less than 0.001 vs. uterine artery and myometrium). The uterine isthmus showed some higher uptake capacity for 3H-NA than did the uterine fundus: 24 +/- 2 vs. 20 +/- 1 ng/g, respectively (p less than 0.05). No difference was found between the 3H-NA values for the proliferative and the secretory phase in tissues examined. High concentrations of oestradiol and progesterone effectively inhibited the 3H-NA uptake (p less than 0.05-0.001). Inhibition was greatest in the oviduct and lowest in the uterine fundus and weaker at the lower concentrations of oestradiol and progesterone.
Saarikoski
S
S
Department of Obstetrics and Gynaecology, University Central Hospital of Kuopio, Finland.
D000328:Adult; D001158:Arteries / Q000378:metabolism; D003042:Cocaine / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D005187:Fallopian Tubes / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009215:Myometrium / Q000187:drug effects / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000378:metabolism*; D014599:Uterus / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism
D011941:Receptors, Adrenergic; D011374:Progesterone; D004958:Estradiol; D003042:Cocaine; D009638:Norepinephrine