An alternative pharmacological approach to the detection of anti-androgenic drugs for acne therapy.
Both testosterone and dihydrotestosterone may be able to stimulate sebaceous glands, and the glandular function may continue under direct testosterone control in the presence of 5 alpha-reductase blockade. Antagonism of sebaceous gland hypertrophy, induced by exogenous testosterone or dihydrotestosterone, has been studied in the hairless hamster using established and experimental drugs applied topically. The results support the proposition that testosterone plays a direct role in mediating sebaceous gland response. This suggests possibilities for the design of sebum inhibitory drugs with minimal systemic anti-androgenic side effects.
Clanachan
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I
Devitt
H
H
Foreman
M I
MI
Picton
W
W
D000152:Acne Vulgaris / Q000188:drug therapy*; D000726:Androgen Antagonists / Q000627:therapeutic use*; D000818:Animals; D006224:Cricetinae; D013196:Dihydrotestosterone / Q000037:antagonists & inhibitors; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005260:Female; D006984:Hypertrophy / Q000517:prevention & control; D012627:Sebaceous Glands / Q000473:pathology; D013739:Testosterone / Q000037:antagonists & inhibitors; D013997:Time Factors
D000726:Androgen Antagonists; D013196:Dihydrotestosterone; D013739:Testosterone