title: Erythrocyte membrane abnormalities in patients with amyotrophic chorea with acanthocytosis. Part 1. Spin labeling studies and lipid analyses.
abstract: Low fluidity was observed in the erythrocyte membranes of familial chorea-acanthocytosis by spin labeling with 12NS. The high content of the saturated fatty acids support the finding of low fluidity. Other lipid contents (cholesterol and phospholipids) and the cholesterol/phospholipid ratio were within normal ranges. The sharp decrease in the parameter, (h0/h-1)1/2, suggests phase separation deep inside the patients' erythrocyte membrane matrix. This distortion of the membrane matrix may be caused by membrane components other than the lipid components.
authors.forename: M
authors.initials: M
authors.lastname: Oshima
authors.forename: Y
authors.initials: Y
authors.lastname: Osawa
authors.forename: K
authors.initials: K
authors.lastname: Asano
authors.forename: T
authors.initials: T
authors.lastname: Saito
mesh_terms: D000050:Acanthocytes / Q000502:physiology*; D002819:Chorea / Q000097:blood / Q000235:genetics*; D004910:Erythrocyte Membrane / Q000032:analysis / Q000502:physiology*; D004913:Erythrocytes, Abnormal / Q000502:physiology*; D006801:Humans; D006816:Huntington Disease / Q000097:blood; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000032:analysis*; D009133:Muscular Atrophy / Q000097:blood / Q000235:genetics*; D013577:Syndrome
chemical_list: D008563:Membrane Lipids