MDL 72832, a selective 5-HT1A receptor ligand, stereospecifically increases food intake.
Effects of the enantiomers of MDL 72832, a novel, potent and selective ligand for 5-HT1A sites, were investigated in a test of platable food consumption in partially pre-satiated male rats. (-)-MDL 72832 significantly increased feeding at 0.03 mg/kg s.c., whereas 1.0 mg/kg (+)-MDL 72832 was required to stimulate food intake. The stereospecificity of the effect provides support for a functional role of 5-HT1A receptors in feeding responses.
Neill
J C
JC
Department of Psychology, University of Birmingham, Birmingham, U.K.
Cooper
S J
SJ
D000818:Animals; D004435:Eating / Q000187:drug effects*; D008297:Male; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D013141:Spiro Compounds / Q000494:pharmacology*; D013237:Stereoisomerism
D011743:Pyrimidines; D011985:Receptors, Serotonin; D013141:Spiro Compounds; C056635:MDL 72832; C043077:ipsapirone; C039979:gepirone