Dehydroepiandrosterone sulphate loading test and determination of plasma oestetrol concentration in late pregnancy.
Intravenous application of dehydroepiandrosterone sulphate (DHEA-S) was performed in 6 women with normal progress of pregnancy, 3 pregnant women with multiple pregnancy and 4 pregnants with intrauterine death of the foetus (32nd to 38th week). The oestetrol concentrations in blood serum were estimated during 5 h after the injection. In most cases an increase could be observed, but this was inhomogenous. The oestetrol concentration even rises in cases of intrauterine death of the foetus. In 7 cases of uncomplicated pregnancies the DHEA-S loading test was done within 2 to 6 h before delivery. The oestetrol concentration in the cord serum of the newborns was not higher than in controls without DHEA-S application, whereas oestradiol in maternal serum showed the expected rise. We conclude that the determination of oestetrol after DHEA-S loading can not be used for the judgement of the foetal situation.
Schollberg
K
K
Seiler
E
E
Wagner
S
S
D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives*; D019314:Dehydroepiandrosterone Sulfate; D004953:Estetrol / Q000097:blood*; D004964:Estriol / Q000031:analogs & derivatives*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005313:Fetal Death / Q000097:blood; D006801:Humans; D011247:Pregnancy; D011272:Pregnancy, Multiple
D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D004953:Estetrol; D004964:Estriol