title: The relationship between the structures of four beta-lactamases obtained from Bacillus cereus.
abstract: Bacillus cereus has proved to be one of the most interesting microorganisms in the study of beta-lactamases. It secrets these enzymes very efficiently and, frequently, in multiple forms. Three different forms are produced by strain 569/H; mutant 5/B of the same microorganism is constitutive for the secretion of beta-lactamases I and II. The present study, based on secondary structure prediction by two independent methods, states the relationship among the structures of beta-lactamases I, II and III produced by B. cereus 569/H and beta-lactamase I from the strain 5/B of this microorganism. A strong similarity is also established for the enzyme type III of B. cereus and the enzyme type I produced by B. licheniformis which could have an evolutionary explanation. A structural analysis of the leader peptide regions of these enzymes by the method of Mohana and Argos is also reported.
authors.affiliation: Depto. de Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Chile.
authors.forename: H
authors.initials: H
authors.lastname: Cid
authors.forename: O
authors.initials: O
authors.lastname: Carrillo
authors.forename: M
authors.initials: M
authors.lastname: Bunster
authors.forename: J
authors.initials: J
authors.lastname: Martínez
authors.forename: V
authors.initials: V
authors.lastname: Vargas
mesh_terms: D001409:Bacillus cereus / Q000201:enzymology*; D015394:Molecular Structure; D011487:Protein Conformation; D001618:beta-Lactamases / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001618:beta-Lactamases