title: Time and dose dependency of bone-sarcomas in patients injected with radium-224.
abstract: The time course and dose dependency of the incidence of bone-sarcomas among 900 German patients treated with high doses of radium-224 is analysed in terms of a proportional hazards model with a log-normal dependency of time to tumor and a linear-quadratic dose relation. The deduced dose dependency agrees well with a previous analysis in terms of a non-parametric proportional hazards model, and confirms the temporal distribution which has been used in the Radioepidemiological Tables of NIH. However, the linear-quadratic dose-response model gives a risk estimate for low doses which is somewhat less than half that obtained under the assumption of linearity.
authors.affiliation: Gesellschaft für Strahlen- und Umweltforschung (GSF) München, Institut für Strahlenschutz, Neuherberg, Federal Republic of Germany.
authors.forename: D
authors.initials: D
authors.lastname: Chmelevsky
authors.forename: A M
authors.initials: AM
authors.lastname: Kellerer
authors.forename: C E
authors.initials: CE
authors.lastname: Land
authors.forename: C W
authors.initials: CW
authors.lastname: Mays
authors.forename: H
authors.initials: H
authors.lastname: Spiess
mesh_terms: D000328:Adult; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008433:Mathematics; D009381:Neoplasms, Radiation-Induced; D012516:Osteosarcoma / Q000453:epidemiology* / Q000209:etiology; D011883:Radium / Q000009:adverse effects*; D012307:Risk Factors; D013997:Time Factors
chemical_list: D011883:Radium