A calcium-dependent rather than a G-protein mechanism is involved in the inward current evoked by muscarinic receptor stimulation in dialysed single smooth muscle cells of small intestine.
A role of internal calcium was found in the inward current response of single, dispersed, smooth muscle cells to muscarinic receptor activation but no obligatory role for guanine nucleotide binding proteins, in contrast to their obligatory role in muscarinic responses in heart and other tissues.
Lim
S P
SP
Department of Pharmacology, St George's Hospital Medical School, London.
Bolton
T B
TB
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002217:Carbachol / Q000494:pharmacology; D003956:Dialysis; D004533:Egtazic Acid / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D019204:GTP-Binding Proteins / Q000502:physiology*; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000031:analogs & derivatives*; D006160:Guanosine Triphosphate / Q000031:analogs & derivatives / Q000494:pharmacology; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D007478:Iontophoresis; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*; D013873:Thionucleotides / Q000494:pharmacology
D011976:Receptors, Muscarinic; D013873:Thionucleotides; C034883:guanosine 5'-O-(2-thiotriphosphate); D016244:Guanosine 5'-O-(3-Thiotriphosphate); D004533:Egtazic Acid; D006160:Guanosine Triphosphate; D002217:Carbachol; D019204:GTP-Binding Proteins; D002118:Calcium