title: [Effect of intrauterine exposure to ethanol on synthesis of various phospholipids in the rat brain during the postnatal period].
abstract: Male rats, whose mothers were given ethanol during pregnancy, were injected inorganic P32 into lateral brain ventricles. Some animals during 1 hour before decapitation were subjected to stress. Phosphatidylethanolamine, phosphatidylcholine and phosphatidylserine were isolated from neocortex and hippocamp. Prenatal alcohol treatment led to 30% inorganic P32 incorporation increase into neocortex phosphatidylcholine. Stress was followed by phosphatidylcholine synthesis level decrease in neocortex by 13% and in hippocamp by 26%. Amplitude of phospholipid synthesis alterations increased after both prenatal alcohol treatment and stress. The results show that prenatal alcohol treatment results in essential disfunction of brain phospholipids synthesis.
authors.forename: V V
authors.initials: VV
authors.lastname: Zhulin
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000378:metabolism; D005333:Fetus / Q000187:drug effects; D010743:Phospholipids / Q000096:biosynthesis*; D011247:Pregnancy; D051381:Rats
chemical_list: D010743:Phospholipids; D000431:Ethanol
vernacular_title: Vliianie vnutriutrobnogo vozdeĭstviia étanola na sintez nekotorykh fosfolipidov mozga krys v postnatal'nom periode.