title: Comparison of prosthetic materials for abdominal wall reconstruction in the presence of contamination and infection.
abstract: Abdominal wall defects resulting from trauma, invasive infection, or hernia present a difficult problem for the surgeon. In order to study the problems associated with the prosthetic materials used for abdominal wall reconstruction, an animal model was used to simulate abdominal wall defects in the presence of peritonitis and invasive infection. One hundred guinea pigs were repaired with either polytetrafluorethylene (PTFE) or polypropylene mesh (PPM). Our experiments included intra-operative contamination with Staphylococcus aureus. We found significantly fewer organisms (p less than 0.05) adherent to the PTFE than to the PPM when antibiotics were administered after surgery, as well as when no antibiotics were given. In the presence of peritonitis, we found no real difference in numbers of intraperitoneal bacteria present whether PTFE or PPM was used. In all instances, the PTFE patches produced fewer adhesions and were more easily removed. From these experiments, it appears that PTFE may be associated with fewer problems than PPM in the presence of contamination and infection.
authors.forename: G L
authors.initials: GL
authors.lastname: Brown
authors.forename: J D
authors.initials: JD
authors.lastname: Richardson
authors.forename: M A
authors.initials: MA
authors.lastname: Malangoni
authors.forename: G R
authors.initials: GR
authors.lastname: Tobin
authors.forename: D
authors.initials: D
authors.lastname: Ackerman
authors.forename: H C
authors.initials: HC
authors.lastname: Polk
mesh_terms: D000009:Abdominal Muscles / Q000601:surgery*; D000818:Animals; D001424:Bacterial Infections / Q000150:complications; D005260:Female; D006168:Guinea Pigs; D010538:Peritonitis / Q000150:complications*; D010969:Plastics; D011126:Polypropylenes; D011138:Polytetrafluoroethylene; D013203:Staphylococcal Infections / Q000150:complications; D013526:Surgical Mesh; D013530:Surgical Wound Infection / Q000150:complications*; D000267:Tissue Adhesions / Q000209:etiology
chemical_list: D010969:Plastics; D011126:Polypropylenes; D011138:Polytetrafluoroethylene