title: Relative lack of systemic effects of mometasone furoate on Langerhans cells of mice after topical administration as compared with other glucocorticosteroids.
abstract: The effects of topically applied mometasone furoate were compared with those of other glucocorticosteroids, in particular fluocinolone acetonide, in assays of murine epidermal Ia+ Langerhans cell density. No evidence of systemic effects, as determined by a decline in the density of Ia+ LC in distant sites, was detected after local topical applications (5 times a week) of mometasone furoate 0.001% for periods of up to 3 weeks. Other steroids, even in such very low concentrations, and mometasone furoate in higher concentrations, produced systemic effects on Ia+ LC when used for longer than 5 d. The recovery time of Ia+ Langerhans cells is significantly shorter after application of mometasone furoate than after fluocinolone acetonide. However, with both compounds, recovery occurred more rapidly after 3 weeks than after a 1- or 2-week interval of compound administration.
authors.affiliation: Department of Dermatology, New York University School of Medicine, New York.
authors.forename: D V
authors.initials: DV
authors.lastname: Belsito
authors.forename: R L
authors.initials: RL
authors.lastname: Baer
authors.forename: J M
authors.initials: JM
authors.lastname: Schultz
authors.forename: G J
authors.initials: GJ
authors.lastname: Thorbecke
mesh_terms: D000287:Administration, Topical; D000818:Animals; D004423:Ear / Q000187:drug effects / Q000473:pathology; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000494:pharmacology*; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007801:Langerhans Cells / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D000068656:Mometasone Furoate; D011244:Pregnadienediols / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D005938:Glucocorticoids; D000949:Histocompatibility Antigens Class II; D011244:Pregnadienediols; D000068656:Mometasone Furoate