In vivo leukocyte chemotaxis during the development of acute experimental Trypanosoma cruzi infection.
Five and 15 days after T. cruzi infection, staphylococcal protein A was injected into a connective tissue air pouch of mice and the migration of polymorphonuclear leukocytes into the area was monitored. The PMN leukocyte response of 15-day infected mice was lower than that of uninfected mice (P less than 0.001): The 15-day infected mice also showed a lower PMN leukocyte response when compared to 5-day infected mice (P less than 0.001). These data suggest that the chemotaxis defect developed gradually during the acute phase of infection.
Abath
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FG
Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Recife, Brasil.
Montenegro
S M
SM
Carvalho
A B
AB
D000818:Animals; D014355:Chagas Disease / Q000276:immunology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000502:physiology; D013205:Staphylococcal Protein A / Q000494:pharmacology
D013205:Staphylococcal Protein A