[Fertilization in vitro with frozen donor sperm after ovocyte stimulation with an LH-RH analog, HMG, and HCG using a short-term protocol].
Frozen cryoprotected donor sperm can be used for IVF.ET. Short administration of Gn.RH analogue with HMG and HCG (Decapeptyl) are used in 39 cycles. Seven clinical pregnancies were obtained, including one which resulted from the transfer of frozen embryos. One spontaneous abortion occurred after 7 weeks amenorrhea. Pregnancy rates are 17.9% per induction cycle, 24.1% per oocyte recovery and 26.9% per embryo transfer. Cumulative pregnancy rate for one year (3 attempts at donor sperm IVF.ET) is 44.7%, but 69.9% if we consider patients who have previously benefited from 12 to 24 AID cycles. The AID success rate is 66% for the 12 months of the first year, 42.3% in the second year and 24.2% in the third year of treatment. These data make it possible to use donor sperm with IVF.ET if tubal disease is associated with severe male factors and if the women fail to conceive after 12, 18 or 24 AID cycles, depending on their age and the existence of hormonal, cervical, tubal or pelvic associated factors.
Sagot
P
P
Département Gynécologie-Obstétrique et Biologie de la Reproduction, C.H.U. de Nantes.
Barrière
P
P
Lopes
P
P
Anger
P
P
Dantal
F
F
Charbonnel
B
B
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005615:Freezing; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008596:Menotropins / Q000008:administration & dosage*; D009865:Oocytes / Q000187:drug effects*; D010060:Ovulation / Q000187:drug effects*; D013074:Sperm Banks; D013094:Spermatozoa; D013480:Superovulation / Q000187:drug effects*; D014021:Tissue Preservation
D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins
Fécondation in vitro avec sperme congelé de donneur après stimulation ovocytaire par analogue Gn-RH, HMG, HCG selon le protocole court.