Low-renin hypertension of childhood.
Measurement of plasma renin activity (PRA) and aldosterone with a knowledge of dietary sodium balance is critical to the diagnostic evaluation of childhood hypertension. Disturbances of steroid production, regulation, metabolism and sensitivity have been implicated in the pathogenesis of low-renin hypertension in childhood. Prompt initiation of treatment is essential because the hemodynamic changes caused by long-standing hypertension may become irreversible. The clinical features and hormonal findings of the most important adrenocortical disorders associated with low-renin hypertension in childhood are summarized.
DiMartino-Nardi
J
J
Department of Pediatrics, New York Hospital-Cornell Medical Center, NY 10021.
New
M I
MI
D000293:Adolescent; D000450:Aldosterone / Q000097:blood; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D007223:Infant; D012083:Renin / Q000097:blood*
D000450:Aldosterone; D012083:Renin