[Interaction of prostaglandins with low-density lipoproteins in human blood].
Interaction of prostaglandins (PG) with human plasma low density lipoproteins (LDL) was studied, using fluorescent spectroscopy and photoreactive labeling. It was demonstrated that PGE1 at low concentrations (less than 10(-9) M) induces specific lipid rearrangements on the surface of LDL globules. It was assumed that these rearrangements are brought about by the interaction of PG with apolipoprotein B to form short-living complexes. A possible mechanism and biological significance of the observed phenomenon are discussed.
Martynova
M A
MA
Manevich
E M
EM
Vodovozova
E L
EL
Muzia
G I
GI
Bezuglov
V V
VV
D000527:Alprostadil / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D015232:Dinoprostone / Q000097:blood; D005456:Fluorescent Dyes; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D011453:Prostaglandins / Q000097:blood*; D011460:Prostaglandins F / Q000097:blood; D013050:Spectrometry, Fluorescence
D001055:Apolipoproteins B; D005456:Fluorescent Dyes; D008077:Lipoproteins, LDL; D011453:Prostaglandins; D011460:Prostaglandins F; D000527:Alprostadil; D015232:Dinoprostone; C100006:prostaglandin F1
Vzaimodeĭstvie prostaglandinov s lipoproteinami nizkoĭ plotnosti krovi cheloveka.