title: The activation of T cells with Staphylococcus aureus Cowan 1 (SAC).
abstract: We reported our findings on the activation and functional capacity of human T cells stimulated by Staphylococcus aureus Cowan 1 (SAC). Serial determinations of surface markers on T cells stimulated by SAC showed that OKT4+ T cells remained relatively constant with the decrease of OKT8+ T cells and that Tac antigen was predominantly expressed on OKT4+ T cells. When the mixture of OKT4+-depleted T cells and OKT8+-depleted PBL was stimulated with SAC or PWM, PWM-stimulated OKT4+-depleted T cells suppressed immunoglobulin production by OKT8+-depleted PBL in a dose-dependent fashion, but SAC-stimulated OKT4+-depleted T cells did not show suppressive activity.
authors.forename: A
authors.initials: A
authors.lastname: Ishizaka
authors.forename: Y
authors.initials: Y
authors.lastname: Sakiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Matsumoto
mesh_terms: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D011971:Receptors, Immunologic / Q000276:immunology; D015375:Receptors, Interleukin-2; D013211:Staphylococcus aureus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2