Cartilage keratan sulphate: changes in chain length with ageing.
Keratan sulphate from sheep nasal cartilage of five different ages was isolated by a combination of methods. The mean length of the chains progressively increased with ageing, as assessed by the molar ratio of glucosamine to galactosamine or galactosaminitol. The mean length ranges from eight monosaccharides for the younger to seventeen monosaccharides for the older animals. The results suggest that the increase in keratan sulphate content of cartilage may be due to the increase in the length and not in the number of chains.
Theocharis
D A
DA
Kalpaxis
D L
DL
Tsiganos
C P
CP
D000375:Aging; D000818:Animals; D002356:Cartilage / Q000032:analysis*; D002850:Chromatography, Gel; D005688:Galactosamine / Q000031:analogs & derivatives / Q000032:analysis; D005944:Glucosamine / Q000032:analysis; D006025:Glycosaminoglycans / Q000032:analysis*; D007632:Keratan Sulfate / Q000032:analysis*; D012756:Sheep; D013329:Structure-Activity Relationship
D006025:Glycosaminoglycans; D005688:Galactosamine; D007632:Keratan Sulfate; D005944:Glucosamine