[Analysis of a model of the miniature endplate current].
The numerical model of the miniature end-plate current MEPC described earlier was systematically analyzed to obtain an optimal set of parameters. This set permits simulating a number of experimental effects: time course of normal MEPC, cholinesterase inhibition, alpha-bungarotoxin action, potential dependence of MEPC, etc. The time course of the simulated "giant" MEPC fitted the experimental data only partially. A good correspondence between the model and experimental data underlies the conclusion that this model reflects well the relative contribution of several processes to MEPC generation.
Nigmatullin
N R
NR
Snetkov
V A
VA
Nikol'skiĭ
E E
EE
Magazanik
L G
LG
D000818:Animals; D002038:Bungarotoxins / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D008433:Mathematics; D008564:Membrane Potentials / Q000187:drug effects; D008954:Models, Biological; D009045:Motor Endplate / Q000187:drug effects / Q000502:physiology*; D009469:Neuromuscular Junction / Q000502:physiology*
D002038:Bungarotoxins; D002800:Cholinesterase Inhibitors
Analiz modeli miniatiurnogo toka kontsevoĭ plastinki.