Partial duplication of chromosome 1q preceding the development of an L3 lymphoblastic leukemia with t(8;14), secondary to treatment for Hodgkin's disease.
We report on a case of secondary lymphoblastic leukemia L3 in a patient treated with chemo- radiotherapy for a previous Hodgkin's disease. The typical chromosome translocation t(8;14) was found in association with a translocation t(9;19) and a marker chromosome 1, dup(1q). The same marker chromosome had been detected in a few cells of peripheral blood 2 years before the onset of the acute leukemia and may represent a proliferation-associated change, responsible for the initiation of the process of leukemogenesis.
Zollino
M
M
Istituto di Genetica Umana, Facoltà di Medicina A. Gemelli, Roma, Italy.
Genuardi
M
M
De Santis
R
R
Leone
G
G
Marra
R
R
Mancini
R
R
Mango
G
G
Neri
G
G
D000328:Adult; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002898:Chromosomes, Human, Pair 8; D006689:Hodgkin Disease / Q000150:complications / Q000628:therapy*; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000209:etiology / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic