Living donor kidney transplants.
1. Whites showed an increase in graft survival in the 2-haplotype matched transplant recipients compared to black recipients at 1-, 2-, and 3-years posttransplant. The difference was not found in the Asian population. Comparing 1-versus 2-haplotype matched transplants showed an increasing statistical significance at yearly intervals, indicating that there was increased HLA chromosome matching effect at 2 and 3 years. Additionally, 2-haplotype matched transplant regrafts showed similar results to first grafts; however, 1-haplotype matched regrafts did poorly relative to 1-haplotype matched first grafts. 2. Living nonrelated transplants and 0-haplotype matched transplants did well initially at 1-year graft survival but there was a decrease in graft survival in these transplant groups at 2 and 3 years. 3. Sensitized patients who received transplants from their mother or father showed an increase in transplant survival in the former and decreased transplant survival in the latter. This may be associated with the exposure in utero of the recipient to the noninherited maternal antigens, thus allowing the better graft survival with the mother as the donor. 4. Cyclosporine showed little effect on graft survival with the exception of a statistically significant difference only in 1-year graft survival for 1-HLA haplotype matched transplant recipients. However, an inverse effect was noted for mother-to-child transplants where CsA treatment showed statistically significant poorer transplant survival a 1 and 2 years. 5. In 1-haplotype matched transplants, neither random transfusion nor donor-specific transfusion exerted much effect.(ABSTRACT TRUNCATED AT 250 WORDS)
Cicciarelli
J
J
D000206:Actuarial Analysis; D001803:Blood Transfusion; D003928:Diabetic Nephropathies / Q000601:surgery; D005190:Family; D005260:Female; D006085:Graft Survival; D006680:HLA Antigens / Q000276:immunology; D006239:Haplotypes; D006648:Histocompatibility; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D010290:Parents; D044469:Racial Groups; D012307:Risk Factors; D014019:Tissue Donors
D006680:HLA Antigens; D007518:Isoantibodies