[Cardiac transplantation at the University Hospital Center of Nantes. 2 years' experience].
Between March, 1985 and April, 1987, 25 orthotopic heart transplantations were performed in 20 men and 5 women aged from 17 to 58 years (mean 42 years) on account of cardiomyopathy (n = 15), ischaemic heart disease (n = 6) or miscellaneous lesions (n = 4). The immunosuppressive treatment consisted of antilymphocyte serum and corticosteroids during 10 days; cyclosporine was introduced on the 7th day and continued thereafter in association with low-dose corticosteroid therapy. Endomyocardial biopsies were performed. Acute rejection, responsible for 2 deaths (one on the 10th day, the other in the 10th week), usually occurred within the first 3 months. Infections were frequent and often serious, resulting in one death in the 7th week. One out of patients had to be treated for arterial hypertension, and 3 patients presented with renal impairment (blood creatinine over 200 mumoles/l). The actuarial survival rate at 2 years is 84 p. 100. More than one-half of the patients have resumed social and occupational activities.
Petit
T
T
Service de cardiologie, hôpital Laënnec, Nantes.
Train
M
M
Treilhaud
M
M
de Lajartre
A Y
AY
Michaud
J L
JL
Despins
P
P
Duveau
D
D
Portier
D
D
Godin
J F
JF
Petitier
H
H
D000206:Actuarial Analysis; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D009202:Cardiomyopathies / Q000628:therapy; D002985:Clinical Protocols; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006086:Graft vs Host Disease; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications
D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents
Transplantation cardiaque au CHU de Nantes. Deux ans d'expérience.