An evaluation of two-dimensional electrophoresis for detection of human serum proteins in acute myocardial infarction.
High resolution two-dimensional electrophoresis indicates that serum proteins previously only detected in patients with acute myocardial infarction (AMI) (Gomo et al., Electrophoresis 1983, 4, 298-302) are also present in the serum protein patterns of other patients (AMI negative or demonstrating acute phase response) and are faintly detected even in controls. Thus, these proteins are not specific to AMI and are probably acute phase reactants. However, they do demonstrate a characteristic time course response in sequential samples from AMI patients.
Marshall
T
T
Biology Department, University of Ulster, Coleraine, Northern Ireland.
Williams
J
J
Williams
K M
KM
D000210:Acute-Phase Reaction / Q000097:blood; D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000302:isolation & purification*; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009203:Myocardial Infarction / Q000097:blood*
D001798:Blood Proteins