title: Fecapentaene causes sister-chromatid exchanges in human lymphocytes.
abstract: Fecapentaenes are potent mutagenic compounds found in human feces that are considered as potential colon carcinogens. It is demonstrated that a synthetic racemic all-trans fecapentaene-12 (fec-12) causes a strong dose-dependent increase in the frequency of sister-chromatid exchanges (SCE) in human lymphocytes exposed at different stages of the cell cycle. The SCE-inducing capacity is consistent with published results on the DNA-damaging activity of fec-12 such as formation of DNA single-strand breaks and interstrand cross-links.
authors.affiliation: Institut für Strahlenbiologie, GSF, Munich, F.R.G.
authors.forename: M
authors.initials: M
authors.lastname: Bauchinger
authors.forename: R
authors.initials: R
authors.lastname: Bartha
authors.forename: E
authors.initials: E
authors.lastname: Schmid
authors.forename: H R
authors.initials: HR
authors.lastname: Pfaendler
mesh_terms: D002453:Cell Cycle; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D011090:Polyenes / Q000008:administration & dosage / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
chemical_list: D011090:Polyenes; C037357:1-(1-glycero)dodeca-1,3,5,7,9-pentaene