[Primary cardiomyopathies and disorders of myocardial energy metabolism: causes or consequences?].
In this review paper, the authors summarize the studies which support the theory that a defect in production of energy by the myocardial cells is a determinant factor in the genesis and/or aggravation of dilated cardiomyopathy. Points that are common to this metabolic theory and to the other pathogenetic mechanisms usually described (notably viral or toxic mechanisms) are presented.
Duboc
D
D
Service des maladies cardio-vasculaires, Hôpital Cochin, Paris.
Toussaint
M
M
Guerin
F
F
Degeorges
M
M
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects; D009202:Cardiomyopathies / Q000209:etiology*; D002310:Cardiomyopathy, Alcoholic / Q000378:metabolism; D002311:Cardiomyopathy, Dilated / Q000378:metabolism; D002331:Carnitine / Q000172:deficiency; D006224:Cricetinae; D004734:Energy Metabolism; D006801:Humans; D008929:Mitochondria, Heart / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D012907:Smoking / Q000009:adverse effects
D000903:Antibiotics, Antineoplastic; D002331:Carnitine
Myocardiopathies primitives et troubles du métabolisme énergétique myocardique: causes ou conséquences?