title: Direct demonstration of production of transforming growth factor activity by embryonic chick tissue.
abstract: The presence of transforming growth factor activity in early chick embryos was directly demonstrated by the ability of limb and tail buds to induce anchorage independent division in NRK 49 f cells. Colony number increased with limb bud number and developmental stage. Medium conditioned by tail buds contained some stimulating effect, and strongly promoted the action of other transforming growth factors.
authors.affiliation: Department of Biology and Preclinical Medicine, University of St. Andrews, Scotland.
authors.forename: J C
authors.initials: JC
authors.lastname: McLachlan
authors.forename: J
authors.initials: J
authors.lastname: Macintyre
authors.forename: D D
authors.initials: DD
authors.lastname: Hume
authors.forename: J
authors.initials: J
authors.lastname: Smith
mesh_terms: D000818:Animals; D002642:Chick Embryo; D046508:Culture Techniques; D005121:Extremities / Q000196:embryology / Q000378:metabolism; D010452:Peptide Biosynthesis; D013623:Tail / Q000196:embryology / Q000378:metabolism; D013997:Time Factors; D015291:Transforming Growth Factors
chemical_list: D015291:Transforming Growth Factors