Effect of ofloxacin on the pharmacokinetics of a single intravenous theophylline dose.
The effect of ofloxacin taken for 8 days (200 mg twice daily) on the pharmacokinetics of a single intravenous dose of theophylline (4.3 mg/kg over 15 min) was studied in a crossover procedure among seven healthy male volunteers. Theophylline concentrations were measured serially for 10 h by the immunofluorescence polarization technique. No significant effect of ofloxacin was found on theophylline clearance, half-life, or volume of distribution. It is therefore concluded that ofloxacin and theophylline can be safely administered together.
Al-Turk
W A
WA
Faculty of Pharmacy, University of Jordan, Amman.
Shaheen
O M
OM
Othman
S
S
Khalaf
R M
RM
Awidi
A S
AS
D000328:Adult; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology*; D013806:Theophylline / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin; D013806:Theophylline