Rate of bactericidal activity for Branhamella catarrhalis of fleroxacin compared with that of amoxycillin-clavulanic acid.
The rate of bactericidal activity of fleroxacin was compared with that of the combination of amoxycillin and clavulanic acid (in the proportion of 4 to 1) on beta-lactamase producing strains of Branhamella catarrhalis. The rate of bactericidal activity of 1 mg/l was as rapid as that of 1 mg/l of amoxycillin-clavulanic acid combination. This rate was not significantly more rapid if the concentrations of fleroxacin were increased to 10 mg/l. In conclusion, the bactericidal activity of fleroxacin is at least as good as that of the combination of amoxycillin and clavulanic acid. Fleroxacin showed a bactericidal effect for B. catarrhalis at concentrations that would be achieved in humans.
Yourassowsky
E
E
Department of Microbiology, Brugmann University Hospital, Brussels, Belgium.
Van der Linden
M P
MP
Lismont
M J
MJ
Crokaert
F
F
Glupczynski
Y
Y
D000658:Amoxicillin / Q000494:pharmacology*; D019980:Amoxicillin-Potassium Clavulanate Combination; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002969:Clavulanic Acids / Q000494:pharmacology*; D003470:Culture Media; D004359:Drug Therapy, Combination / Q000494:pharmacology; D016576:Fleroxacin; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects*
D000890:Anti-Infective Agents; D002969:Clavulanic Acids; D003470:Culture Media; D002939:Ciprofloxacin; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin; D016576:Fleroxacin