title: [Treatment of refractory status convulsivus with chlormethiazole].
abstract: A 5 years old girl with status epilepticus refractory to treatment with Diphenylhydantoin at a dose of 30 mg/kg/day and Thiopental in continuous IV perfusion at a dose of 4 mg/kg/h is presented. Control of status was achieved by continuous IV perfusion of Chlormethiazole at a dose of 10 mg/kg/h which also caused respiratory depression. Seizure activity reappeared after IV perfusion of Chlormethiazole was retired, and could be controlled only with Sodium Valproate. Mechanisms of action of Chlormethiazole and its effectiveness in treatment of refractory status epilepticus are revised.
authors.affiliation: Unidad de Cuidados Intensivos Pediátricos, Hospital Infantil La Paz, Madrid.
authors.forename: M J
authors.initials: MJ
authors.lastname: García García
authors.forename: J
authors.initials: J
authors.lastname: López-Herce Cid
authors.forename: A
authors.initials: A
authors.lastname: Martínez Bermejo
authors.forename: L
authors.initials: L
authors.lastname: Perdikidi Olivieri
authors.forename: F
authors.initials: F
authors.lastname: Rubio de la Iglesia
authors.forename: J
authors.initials: J
authors.lastname: Hernández González
mesh_terms: D002675:Child, Preschool; D002719:Chlormethiazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D012120:Respiration Disorders / Q000209:etiology; D013226:Status Epilepticus / Q000188:drug therapy*; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D002719:Chlormethiazole; D014635:Valproic Acid
vernacular_title: Tratamiento del status convulsivo refractario con clormetiazol.