title: Coexistence of TRH with other neuroactive substances in the rat central nervous system.
abstract: Colocalization of thyrotropin-releasing hormone-like immunoreactivity with other neuroactive substances was examined immunohistochemically in colchicine-treated rat brains using double-staining or elution-restaining methods. Thyrotropin-releasing hormone-like immunoreactivity was shown to be located in the same neurons as: 1. enkephalin-, gamma-amino butyric acid- and tyrosine hydroxylase-, but not somatostatin-like immunoreactivity in the glomerular layer of the olfactory bulb 2. oxytocin- and cholecystokinin-, but not vasopressin-like immunoreactivity in the supraoptic nucleus 3. cholecystokinin-like immunoreactivity in posterior pituitary 4. enkephalin-like immunoreactivity in the perifornical area of the hypothalamus and 5. neuropeptide Y- and neurotensin-like immunoreactivity in the periaqueductal central grey. These findings provide further examples of coexistence of thyrotropin-releasing hormone with classical neurotransmitters and/or peptides in the rat central nervous system.
authors.affiliation: Department of Histology, Karolinska Institute, Stockholm, Sweden.
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuruo
authors.forename: S
authors.initials: S
authors.lastname: Ceccatelli
authors.forename: M J
authors.initials: MJ
authors.lastname: Villar
authors.forename: T
authors.initials: T
authors.lastname: Hökfelt
authors.forename: T J
authors.initials: TJ
authors.lastname: Visser
authors.forename: L
authors.initials: L
authors.lastname: Terenius
authors.forename: M
authors.initials: M
authors.lastname: Goldstein
authors.forename: J C
authors.initials: JC
authors.lastname: Brown
authors.forename: A
authors.initials: A
authors.lastname: Buchan
authors.forename: J
authors.initials: J
authors.lastname: Walsh
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009479:Neuropeptides / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism*
chemical_list: D009479:Neuropeptides; D013973:Thyrotropin-Releasing Hormone