[Spinal mechanism of the antispastic action of TRH in patients with amyotrophic lateral sclerosis].
Effects of high-dose TRH on the vibratory inhibition of soleus H-reflex have been studied in 9 patients with amyotrophic lateral sclerosis. In 6 of the 9, TRH induced a significant increase in vibratory inhibition. This suggests that the TRH-induced reduction of spasticity might be due to an increase in presynaptic inhibition acting on Ia fibres.
Morin
C
C
Laboratoire de Neurophysiologie Clinique, Hôpital de la Salpêtrière, Paris.
Pierrot-Deseilligny
E
E
D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy* / Q000503:physiopathology; D006181:H-Reflex / Q000187:drug effects*; D006801:Humans; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000503:physiopathology; D012023:Reflex, Monosynaptic / Q000187:drug effects*; D013116:Spinal Cord / Q000503:physiopathology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology / Q000627:therapeutic use*
D013973:Thyrotropin-Releasing Hormone
Mécanisme spinal de l'action antispastique de la TRH chez les malades atteints de sclerose latérale amyotrophique.