title: Specific treatment of advanced schistosomiasis liver disease in man: favourable results.
abstract: One hundred eighty-four patients with hepatosplenic schistosomiasis mansoni from the northeast of Brazil were studied. All were treated with a single dose of Oxamniquine or Praziquantel, and were observed over 6 to 12 months. Special attention was given to the evolution of severe hepatopathy. Favourable results were obtained, particularly with the compensated hepatosplenic form. Hepatic function showed great improvement. Hepatomegaly and splenomegaly were significantly reduced in size, to a greater or lesser extent, in the great majority of patients. The implications of the results obtained are considered below.
authors.affiliation: Departamento de Medicina Clínica, Universidade Federal de Pernambuco, Recife PE, Brasil.
authors.forename: A
authors.initials: A
authors.lastname: Coutinho
authors.forename: A L
authors.initials: AL
authors.lastname: Domingues
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004341:Drug Evaluation; D005260:Female; D006521:Hepatitis, Chronic / Q000150:complications; D006529:Hepatomegaly / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D009600:Nitroquinolines / Q000627:therapeutic use*; D010073:Oxamniquine / Q000627:therapeutic use*; D011223:Praziquantel / Q000627:therapeutic use*; D012480:Salmonella Infections / Q000150:complications; D012555:Schistosomiasis mansoni / Q000150:complications / Q000188:drug therapy*; D013163:Splenomegaly / Q000188:drug therapy / Q000209:etiology
chemical_list: D009600:Nitroquinolines; D010073:Oxamniquine; D011223:Praziquantel