title: Identification of another member of the transforming growth factor type beta gene family.
abstract: We report here the complete amino acid sequence of another member of the type beta transforming growth factor gene family, deduced from the nucleotide sequence of three overlapping cDNA clones. The C-terminal 112 amino acids share approximately 80% sequence identity with type beta 1 and beta 2 transforming growth factors, with many of the remaining differences being conservative substitutions. By analogy to type beta 1 and type beta 2 transforming growth factors, we predict the protein to be synthesized as a 412 amino acid precursor that undergoes proteolytic cleavage to produce the mature polypeptide.
authors.affiliation: Oncogene Science, Inc., Manhasset, NY 11030.
authors.forename: P
authors.initials: P
authors.lastname: ten Dijke
authors.forename: P
authors.initials: P
authors.lastname: Hansen
authors.forename: K K
authors.initials: KK
authors.lastname: Iwata
authors.forename: C
authors.initials: C
authors.lastname: Pieler
authors.forename: J G
authors.initials: JG
authors.lastname: Foulkes
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D009363:Neoplasm Proteins / Q000235:genetics; D010455:Peptides / Q000235:genetics*; D012208:Rhabdomyosarcoma / Q000235:genetics / Q000473:pathology; D012689:Sequence Homology, Nucleic Acid; D015291:Transforming Growth Factors; D014407:Tumor Cells, Cultured
chemical_list: D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D010455:Peptides; D015291:Transforming Growth Factors; D004247:DNA