[The effect of cyclo-oxygenase and lipoxygenase inhibitors on anaphylactic vasodepression ex vivo in mice and rats].
Cyclooxygenase inhibitors (diclofenac, indomethacin, piroxicam) does not or only hardly inhibit anaphylactic vasodepression, except acetylsalicylic acid which could act as an oxygen free radical scavenger. However, the dual blocker BW 755 c strongly improves vasodepression. Pure lipoxygenase inhibitors (nordihydroguajaretic acid, oxphaman) only moderately improve vasodepression, the leukotriene antagonist FPL 55,712 is hardly effective. Obviously, endogenous prostaglandins do not and leukotrienes do take little part in the pathogenesis of anaphylactic vasodepression in the mouse and rat.
Bekemeier
H
H
Wissenschaftsbereich Pharmakologie, Martin-Luther-Universität Halle-Wittenberg.
Hänsel
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F
Sänze
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JU
D000707:Anaphylaxis / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors; D005260:Female; D016859:Lipoxygenase Inhibitors; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors
Einfluss von Cyclooxygenase- und Lipoxygenase-Inhibitoren auf die anaphylaktische Vasodepression ex vivo an Maus und Ratte.