title: Lymphocyte subsets in patients with compositae oleoresin dermatitis and increased UVA sensitivity during treatment with azathioprine.
abstract: Four patients with severe contact dermatitis resulting from compositae oleoresin were found to have increased sensitivity to ultraviolet light. All showed a clear reduction of Leu-3a-positive lymphocytes (T helper/inducer cells) and cells expressing the Ia phenotype in their blood. The numbers of T suppressor/cytotoxic (Leu 2a) lymphocytes, monocytes and B lymphocytes were within the normal range. Treatment with azathioprine (150 mg daily) improved the eczema. The number of Leu-3a-positive lymphocytes normalized during therapy, but the number of Ia-positive cells did not.
authors.forename: O
authors.initials: O
authors.lastname: Baadsgaard
authors.forename: C
authors.initials: C
authors.lastname: Geisler
authors.forename: T
authors.initials: T
authors.lastname: Plesner
authors.forename: K
authors.initials: K
authors.lastname: Thestrup-Pedersen
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal; D001379:Azathioprine / Q000627:therapeutic use*; D003877:Dermatitis, Contact / Q000097:blood* / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000209:etiology / Q000276:immunology*; D010936:Plant Extracts / Q000009:adverse effects*; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D000911:Antibodies, Monoclonal; D010936:Plant Extracts; C018620:oleoresins; D001379:Azathioprine