Prognostic indicators in centroblastic-centrocytic lymphoma.
The prognostic importance of ploidy and proliferative index (%S + G2) assessed by flow cytometry, mitotic and centroblast counts, and histological growth pattern were evaluated in biopsy specimens taken before treatment from 60 cases of centroblastic-centrocytic non-Hodgkin's lymphoma. Cases with a high proliferative index (greater than or equal to 18%) or DNA aneuploidy showed significantly poorer survival than those with a low proliferative index (less than 18%). A high mitotic count was also associated with a poor prognosis. On multiple regression analysis the flow cytometric assessments and mitotic counts were significant predictors of survival. Assessments of proliferative activity clearly have prognostic potential in centroblastic-centrocytic lymphoma and may permit more accurate characterisation of individual tumours.
Griffin
N R
NR
Department of Pathology, University of Leeds.
Howard
M R
MR
Quirke
P
P
O'Brien
C J
CJ
Child
J A
JA
Bird
C C
CC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008938:Mitosis; D011379:Prognosis; D013997:Time Factors
D004273:DNA, Neoplasm