Modulation of autoimmunity in NZB mice by cyclophosphamide-induced, nonspecific suppressor cells.
A group of NZB mice received six biweekly injections of cyclophosphamide-induced nonspecific suppressor cells, with treatment commencing at 2 mo of age. Mice were evaluated for Coombs and natural thymocytotoxic antibody at 6-wk intervals thereafter, and for anti-DNA autoantibodies, total IgM and IgG levels, and renal histology at selected time points. The administration of suppressor cells resulted in marked and prolonged suppression of both Coombs and natural thymocytotoxic antibody reactivity in the majority of animals while not measurably affecting the levels of anti-DNA autoantibodies, the total IgM and IgG levels, or the life span of the mice.
Greeley
E H
EH
Segre
M
M
Segre
D
D
D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism; D000961:Antilymphocyte Serum / Q000096:biosynthesis; D001323:Autoantibodies / Q000096:biosynthesis*; D003298:Coombs Test; D003520:Cyclophosphamide / Q000494:pharmacology*; D005260:Female; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D008136:Longevity; D051379:Mice; D008814:Mice, Inbred NZB / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000637:transplantation*
D000936:Antigen-Antibody Complex; D000961:Antilymphocyte Serum; D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D003520:Cyclophosphamide