title: The Colton blood group locus. A linkage analysis.
abstract: Accumulated family information was compiled in an attempt to verify the chromosomal location of the Colton blood group locus (CO). Two-point linkage analysis of CO and 46 other polymorphic loci excludes CO from 1p36 to 1q23, 3q21 to 3q26, 4q13 to 4q28, 6p24 to 6 cen, and 19p13.2 to 19 cen and from linkage groups bounded by ABO and ORM, PI and IGHG, and HP and GOT2. The dwindling odds of linkage between CO:JK are reinforced (z = -5.28 at theta = 0.20). Close linkage of CO with ACP1 and D2S5 could not be demonstrated. The proposed chromosome 2 location of CO is therefore questioned.
authors.affiliation: Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Zelinski
authors.forename: H
authors.initials: H
authors.lastname: Kaita
authors.forename: M
authors.initials: M
authors.lastname: Lewis
authors.forename: G
authors.initials: G
authors.lastname: Coghlan
authors.forename: S
authors.initials: S
authors.lastname: Philipps
authors.forename: E
authors.initials: E
authors.lastname: Belcher
authors.forename: P J
authors.initials: PJ
authors.lastname: McAlpine
authors.forename: G
authors.initials: G
authors.lastname: Coopland
authors.forename: P
authors.initials: P
authors.lastname: Wong
mesh_terms: D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D005796:Genes; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans
chemical_list: D005819:Genetic Markers