Prevention of pulmonary complications by 6-methylprednisolone in major abdominal surgery.
Methylprednisolone sodium succinate (MPSS) was compared in a randomized, double blind study to placebo in the prevention of respiratory complications in patients submitted to abdominal (vascular, pancreatic or hepatic) surgery. Two out of 42 (4.8%) patients treated with MPSS and 9 patients out of 40 (22.5%) who received placebo experienced a pulmonary complication (p less than 0.05) The results indicate that methylprednisolone could prevent the onset of respiratory complications in patients undergoing major abdominal surgery.
Zotti
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GC
Istituto di Chirurgia Generale I e Trapianti d'Organo II Facoltà di Medicina e Chirurgia, Università di Napoli.
Salzano de Luna
F
F
Caiazza
A
A
Santaniello
W
W
Micheletti
G
G
Bruno
A
A
Casadei
C L
CL
D000005:Abdomen / Q000601:surgery*; D001639:Bicarbonates / Q000097:blood; D002245:Carbon Dioxide / Q000097:blood; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000031:analogs & derivatives*; D008776:Methylprednisolone Hemisuccinate / Q000627:therapeutic use*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011183:Postoperative Complications / Q000517:prevention & control*; D011897:Random Allocation; D012140:Respiratory Tract Diseases / Q000097:blood / Q000209:etiology / Q000517:prevention & control*
D001639:Bicarbonates; D002245:Carbon Dioxide; D008776:Methylprednisolone Hemisuccinate; D010100:Oxygen; D008775:Methylprednisolone