title: Stimulation of immunoglobulin-containing cells and isotype-specific antibody response in experimental Mycoplasma hyopneumoniae infection in specific-pathogen-free pigs.
abstract: The development of immunoglobulin-containing cells and antigen-specific plasma cells in retropharyngeal and bronchial lymph nodes, in lung tissue, and in nasal mucous membrane was followed during an experimental infection of pigs with Mycoplasma hyopneumoniae. An enzyme-linked immunosorbent assay was used to follow stimulation of the immunoglobulin isotypes (classes) M, G, and A directed against the infectious agent in tracheobronchial secretions and systemically. A significant increase of antigen-specific plasma cells in lymph nodes and lung tissue as well as antibodies in tracheobronchial secretions was demonstrated 2 weeks after infection. This specific reaction was followed by a marked increase of immunoglobulin-containing cells in lymph nodes and lung tissue. The data are discussed in terms of autoimmune reactions in the pathogenesis of enzootic pneumonia.
authors.forename: M
authors.initials: M
authors.lastname: Suter
authors.forename: M
authors.initials: M
authors.lastname: Kobisch
authors.forename: J
authors.initials: J
authors.lastname: Nicolet
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis*; D000917:Antibody Formation; D002452:Cell Count; D004797:Enzyme-Linked Immunosorbent Assay; D007136:Immunoglobulins / Q000032:analysis*; D009174:Mycoplasma / Q000302:isolation & purification; D009175:Mycoplasma Infections / Q000276:immunology / Q000662:veterinary*; D010950:Plasma Cells / Q000276:immunology; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D007136:Immunoglobulins