Acute monoblastic leukemia as a second malignancy following chemotherapy for osteogenic sarcoma: a case report.
A patient with well-differentiated monoblastic leukemia (ANLL FAB-M5b) is described in whom acute leukemia was diagnosed 25 months after having completed postoperative adjuvant chemotherapy for osteogenic sarcoma of the femur. All analyzed metaphases showed 48xy, dup 1(q12), +3, +9.
Orazi
A
A
Divisione di Anatomia Patologica e Citologia, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy.
Sozzi
G
G
Delia
D
D
Morandi
F
F
Rottoli
L
L
Cattoretti
G
G
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001853:Bone Marrow / Q000473:pathology; D001859:Bone Neoplasms / Q000188:drug therapy*; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000139:chemically induced* / Q000235:genetics; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000209:etiology* / Q000235:genetics; D012516:Osteosarcoma / Q000188:drug therapy*