title: Do evoked potentials measure depth of anaesthesia?
abstract: Somatosensory evoked potentials have been suggested as a possible neurophysiological in of anaesthetic depth. In order to test the usefulness of this technique of monitoring, 8 patients were monitored during balanced anaesthesia. Following induction with a sleep dose of thiopentone, a neuromuscular blocking agent was used and the patients' lungs ventilated with N2O/O2(F1O2 = 0.3). This was supplemented with halothane or fentanyl. Somatosensory evoked potentials were recorded every 10 minutes during surgery, blood pressure and heart rate being recorded at the end of each evoked potential measurement. Induction of anaesthesia was associated with the reduction in SEP amplitude from 4.2 +/- 1.04 micro volts to 1.6 +/- 0.9 micro volts. There was an increase in latency from 19.2 +/- 1.3 msec to 20.0 +/- 1.3 msec to 20.0 +/- 1.5 msec. Recovery from anaesthesia was accompanied by an increase in SEP amplitude pre-induction values. There were no apparent correlations between the changes in evoked potential measures and changes in heart rate or blood pressure. Consistent change in somatosensory evoked potentials (prolonged latency, decreased amplitude) occurred with both narcotic and volatile anaesthetics. There was a recovery of evoked potentials at the end of anaesthesia. This is a promising technique, worthy of further evaluation.
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710.
authors.forename: P S
authors.initials: PS
authors.lastname: Sebel
authors.forename: P
authors.initials: P
authors.lastname: Glass
authors.forename: W K
authors.initials: WK
authors.lastname: Neville
mesh_terms: D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D005073:Evoked Potentials, Somatosensory; D005260:Female; D005283:Fentanyl; D006221:Halothane; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*
chemical_list: D005283:Fentanyl; D006221:Halothane