title: Hemodynamic effects of alpha-human atrial natriuretic polypeptide (alpha-hANP) in rats.
abstract: alpha-Human atrial natriuretic polypeptide (alpha-hANP) was infused in anesthetized Wistar rats, and its hemodynamic effects were investigated by measuring mean blood pressure (MBP), heart rate, cardiac index (CI), stroke volume index (SVI) and total peripheral resistance index (TPRI). alpha-hANP caused a reduction in MBP (approximately 20%) associated with decreases in CI and SVI but caused no change in TPRI. These results suggested that alpha-hANP may lower blood pressure mainly by decreasing cardiac output.
authors.forename: A
authors.initials: A
authors.lastname: Sasaki
authors.forename: O
authors.initials: O
authors.lastname: Kida
authors.forename: K
authors.initials: K
authors.lastname: Kangawa
authors.forename: H
authors.initials: H
authors.lastname: Matsuo
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009124:Muscle Proteins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013318:Stroke Volume / Q000187:drug effects; D014630:Vagus Nerve / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D009124:Muscle Proteins; D009320:Atrial Natriuretic Factor