A preliminary study on the mechanism of neonatal allotransplantation tolerance. Participation of suppressor cells in the mediation of neonatal allotransplantation tolerance.
Using a method from Billingham, an animal model of the neonatal allotransplantation tolerance of SWI to C57BL inbred mice was established and the mechanism of neonatal tolerance established by us was preliminarily studied. Our experiment indicates that the clonal deletion theory is not the unique explanation for the neonatal tolerance and a peripheral active inhibitory mechanism including suppressor cells may participate in mediating and maintaining the neonatal tolerance. The suppressor cells in the neonatal tolerance are radioresistant, but rather sensitive to mitomycin C treatment. These results suggest that suppressor cell population may be nonhomogenous. Further studies about this problem are needed.
Jiang
H
H
Shi
M Y
MY
Yao
L R
LR
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D006789:Host vs Graft Reaction; D007108:Immune Tolerance; D051379:Mice; D008810:Mice, Inbred C57BL; D016038:Skin Transplantation; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014181:Transplantation Immunology; D014184:Transplantation, Homologous