title: A double-blind comparison of ibuprofen, placebo and ibuprofen with meptazinol in soft tissue rheumatism.
abstract: The administration of ibuprofen potentiates and prolongs the analgesic effect of meptazinol when the two drugs are given simultaneously to mice. A double-blind three-way crossover study of placebo, ibuprofen (1600 mg/day) and ibuprofen (1600 mg/day) plus meptazinol (400 mg/day) was carried out in 45 patients with soft tissue rheumatism to see if the same potentiation could be demonstrated in man. Treatment order was randomized and each regimen was given for 2 weeks preceded by 1 week on paracetamol alone. Assessments were made, on entry and after each treatment period, of pain parameters using visual analogue or verbal rating scales. Patients' overall impression and final preference showed both active treatments to be better than placebo and demonstrated a slight preference for the combination.
authors.affiliation: Clinical Pharmacology Unit (Rheumatism Research), Royal Bath Hospital, Harrogate, England.
authors.forename: P
authors.initials: P
authors.lastname: Le Gallez
authors.forename: F B
authors.initials: FB
authors.lastname: Reeve
authors.forename: M A
authors.initials: MA
authors.lastname: Crawley
authors.forename: H A
authors.initials: HA
authors.lastname: Bird
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001381:Azepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005356:Fibromyalgia / Q000188:drug therapy*; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008621:Meptazinol / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D011897:Random Allocation
chemical_list: D001381:Azepines; D008621:Meptazinol; D007052:Ibuprofen