Ontogeny of mitogen responsive lymphocytes in the bovine fetus.
Bovine fetal lymphocytes were examined for their ability to respond to the mitogens phytohemagglutinin (PHA), Concanavalin A (ConA) and pokeweed mitogen (PWM) in the lymphocyte blastogenesis test (LBT). PHA-, Con A- and PWM-responsive lymphocytes appeared simultaneously at 75-80 days of gestation. The response increased with age of the fetus until, by 120 days of gestation, the response to PHA, Con A and PWM of many fetuses was in the range of values obtained with lymphocytes from normal adult cattle.
Jensen
J
J
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
Rubino
M
M
Yang
W C
WC
Cooley
A J
AJ
Schultz
R D
RD
D000818:Animals; D002417:Cattle / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology; D005333:Fetus / Q000276:immunology*; D005865:Gestational Age; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology
D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D003208:Concanavalin A