High-density lipoprotein apolipoprotein AI and AII turnover in moderate and severe proteinuria.
The kinetic parameters of high-density lipoprotein (HDL) and its major apolipoproteins (Apo) AI and Apo AII were studied in 2 patients with moderate and severe proteinuria and 2 normal controls after intravenous injection of autologous 125I-HDL. The fractional catabolic rates (FCR) of HDL estimated by urine/plasma radioactivity ratio, and FCR of Apo AI and Apo AII calculated from the radioactivity decay curves were higher in the patients. These results support the concept that high-density lipoproteinuria and renal parenchymal sequestration of HDL found in the nephrotic syndrome contribute to accelerated HDL catabolism.
Saku
K
K
Department of Internal Medicine, University of Cincinnati Medical Center, Ohio.
Mendoza
S G
SG
Laver
M
M
Hynd
B A
BA
Gartside
P S
PS
Kashyap
M L
ML
D000328:Adult; D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001054:Apolipoproteins A / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008075:Lipoproteins, HDL / Q000097:blood*; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000097:blood* / Q000652:urine; D011507:Proteinuria; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001054:Apolipoproteins A; D007457:Iodine Radioisotopes; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol