[A model of Parkinson's disease: effect of L-dopa therapy on movement parameters and electromyographic activity in monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)].
A primate model of Parkinson's disease was obtained by i. v. administration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). A behavioural, a mechanographic and an electromyographic (EMG) study were carried out during the execution of a rapid elbow movement, in two normal monkeys and, after the MPTP administration, before and after a L-DOPA therapy. Disturbances in behavior, movement parameters and EMG activity observed in MPTP-treated monkeys mimic those reported in Parkinsonian patients. Treatment with L-DOPA was effective in greatly correcting these disturbances. These results lend weight to the assumption that use of MPTP in primate provides a good model to study Parkinson's disease.
Doudet
D
D
Gross
C
C
Lebrun-Grandié
P
P
Bioulac
B
B
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002230:Carbidopa / Q000627:therapeutic use; D004195:Disease Models, Animal; D004338:Drug Combinations / Q000627:therapeutic use; D004576:Electromyography; D007980:Levodopa / Q000627:therapeutic use*; D008253:Macaca mulatta; D009069:Movement Disorders / Q000188:drug therapy; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D011725:Pyridines
D004338:Drug Combinations; D011725:Pyridines; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D002230:Carbidopa
Un modèle de maladie de Parkinson: effet d'une thérapie à la L-dopa sur les paramètres du mouvement et l'activité électromyographique chez le singe traité par le 1-méthyl-4-phényl-1, 2, 3, 6-tétrahydropyridine (MPTP).