title: [Mathematical modeling of the dynamics of the intensity of the mutation process. II. Dynamic evaluation of the frequencies of hereditary pathology].
abstract: Mathematical models were devised to evaluate the dynamics of hereditary pathology frequencies, based on registration of spontaneous abortions, congenital malformations and Down disease in the city of Angarsk during 12 years. The models provide an opportunity to detect the fact of the presence or absence of temporary tendencies. The average frequency of spontaneous abortions and units of hereditary pathology have not been changed for 12 years, the frequency of Down disease being decreased, while congenital malformations seem to change with certain periodicity. In cases of insufficient sample sizes, the prolongation of observation for a period of several years does not facilitate the task of construction of models which could adequately describe multifactor-conditioned processes.
authors.forename: N P
authors.initials: NP
authors.lastname: Bochkov
authors.forename: V G
authors.initials: VG
authors.lastname: Vedenkov
authors.forename: I K
authors.initials: IK
authors.lastname: Volkov
authors.forename: V R
authors.initials: VR
authors.lastname: Dvortsov
authors.forename: R E
authors.initials: RE
authors.lastname: Onishchenko
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000235:genetics; D000013:Congenital Abnormalities / Q000453:epidemiology / Q000235:genetics; D004314:Down Syndrome / Q000453:epidemiology / Q000235:genetics; D005260:Female; D030342:Genetic Diseases, Inborn / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic; D009154:Mutation; D011247:Pregnancy; D012800:Siberia; D014505:Urban Population
vernacular_title: Matematicheskoe modelirovanie dinamiki intensivnosti mutatsionnogo protsessa. Soobshchenie II. Otsenka dinamiki chastot nasledstvennoĭ patologii.