title: Isolation of T-cell tropic HTLV-III-like retrovirus from macaques.
abstract: The isolation of a T-cell tropic retrovirus from three immunodeficient macaques and one macaque with lymphoma is described. The morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of acquired immune deficiency syndrome in humans (HTLV-III or LAV). This virus is referred to as simian T-lymphotropic virus type III (STLV-III) of macaques. The existence of a cytopathic, T-cell tropic virus resembling HTLV-III in monkeys may facilitate study of disease induction and vaccine development in an animal model.
authors.forename: M D
authors.initials: MD
authors.lastname: Daniel
authors.forename: N L
authors.initials: NL
authors.lastname: Letvin
authors.forename: N W
authors.initials: NW
authors.lastname: King
authors.forename: M
authors.initials: M
authors.lastname: Kannagi
authors.forename: P K
authors.initials: PK
authors.lastname: Sehgal
authors.forename: R D
authors.initials: RD
authors.lastname: Hunt
authors.forename: P J
authors.initials: PJ
authors.lastname: Kanki
authors.forename: M
authors.initials: M
authors.lastname: Essex
authors.forename: R C
authors.initials: RC
authors.lastname: Desrosiers
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000662:veterinary*; D000818:Animals; D008223:Lymphoma / Q000382:microbiology / Q000662:veterinary; D008251:Macaca / Q000382:microbiology*; D008253:Macaca mulatta / Q000382:microbiology*; D008992:Monkey Diseases / Q000382:microbiology*; D012190:Retroviridae / Q000302:isolation & purification*; D013601:T-Lymphocytes / Q000382:microbiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000382:microbiology; D014779:Virus Replication