title: A comparative tissue toxicity evaluation of established and newer root canal sealers.
abstract: Grossman's sealer, eucapercha, Endo-Fill, CRCS, Sealapex, Hypocal, and sterile saline solution (0.3 ml of each) were injected into specific dorsal subdermal tissue sites of 12 guinea pigs. The animals were killed after 6 days, 15 days, and 80 days (four per time period). Analysis of tissue response showed that, overall, Sealapex and Endo-Fill had less severe inflammatory reactions than any of the other test materials. Grossman's sealer, CRCS, and Hypocal showed principally severe inflammatory responses at both 6 and 15 days, but mild reactions at 80 days. Overall, eucapercha showed less severe inflammatory responses than Grossman's sealer, CRCS, and Hypocal. Diffuse calcification was induced by the three calcium hydroxide preparations (CRCS, Sealapex, and Hypocal). Eucapercha and Endo-Fill had minute local areas of calcification. Both Grossman's sealer and CRCS did not have overall favorable histologic reactions; however, Grossman's sealer and CRCS have been used successfully clinically. Further clinical studies are needed.
authors.affiliation: Department of Endodontology, Temple University School of Dentistry, Philadelphia, Pa.
authors.forename: C
authors.initials: C
authors.lastname: Yesilsoy
authors.forename: L Z
authors.initials: LZ
authors.lastname: Koren
authors.forename: D R
authors.initials: DR
authors.lastname: Morse
authors.forename: C
authors.initials: C
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D002114:Calcinosis / Q000139:chemically induced; D002126:Calcium Hydroxide / Q000633:toxicity; D004338:Drug Combinations / Q000633:toxicity; D005054:Eugenol / Q000633:toxicity; D006168:Guinea Pigs; D006171:Gutta-Percha / Q000633:toxicity; D006863:Hydrogen-Ion Concentration; D007249:Inflammation; D008297:Male; D008610:Menthol / Q000031:analogs & derivatives / Q000633:toxicity; D012387:Root Canal Filling Materials / Q000633:toxicity*; D012828:Silicones / Q000633:toxicity; D012867:Skin / Q000187:drug effects; D013997:Time Factors; D015035:Zinc Oxide-Eugenol Cement
chemical_list: D004338:Drug Combinations; D012387:Root Canal Filling Materials; D012828:Silicones; D015035:Zinc Oxide-Eugenol Cement; C027897:euchapercha; C045432:Grossman's sealer; D008610:Menthol; D005054:Eugenol; D006171:Gutta-Percha; D002126:Calcium Hydroxide