title: 5q- syndrome terminating in acute myeloid leukemia. Karyotype evolution and immunologic characterization of blast cells.
abstract: We report a case of 5q- syndrome that progressed to acute nonlymphocytic leukemia after 9 years of clinically and morphologically stable disease. The transition from the chronic to the leukemic phase was characterized by the appearance of an additional cytogenetic anomaly [inv(2)] in the cell carrying the 5q-, together with the expansion of a clone showing an apparently normal karyotype.
authors.affiliation: 1st Institute of Internal Medicine, School of Medicine, Perugia University, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Donti
authors.forename: A
authors.initials: A
authors.lastname: Tabilio
authors.forename: G V
authors.initials: GV
authors.lastname: Donti
authors.forename: C
authors.initials: C
authors.lastname: Mecucci
authors.forename: A
authors.initials: A
authors.lastname: Carotti
authors.forename: F
authors.initials: F
authors.lastname: Grignani
authors.forename: M F
authors.initials: MF
authors.lastname: Martelli
mesh_terms: D000753:Anemia, Refractory / Q000150:complications / Q000235:genetics* / Q000473:pathology; D000911:Antibodies, Monoclonal; D001752:Blast Crisis / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013577:Syndrome
chemical_list: D000911:Antibodies, Monoclonal