title: Competitive mechanisms of basic peptides inducing transganglionic degenerative atrophy.
abstract: In addition to the classical microtubule inhibitors (antimitotic agents), transganglionic degenerative atrophy of central terminals of primary sensory neurons can be induced also by means of applying to a peripheral nerve basic polypeptides (Polymyxin B and Colimycin) and two basic derivatives of glutamic acid that do not exert any microtubule inhibition. This effect is independent of other pharmacological effects (histamine liberation, Ca2+ -binding, etc.) of the applied compounds, and probably it is based on a competitive reaction with nerve growth factor.
authors.affiliation: Department of Anatomy, Szent-Györgyi Albert Medical University, Szeged, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Tajti
authors.forename: B
authors.initials: B
authors.lastname: Penke
authors.forename: K
authors.initials: K
authors.lastname: Kovács
authors.forename: B
authors.initials: B
authors.lastname: Csillik
mesh_terms: D000818:Animals; D001284:Atrophy; D003091:Colistin / Q000633:toxicity; D005260:Female; D005971:Glutamates / Q000633:toxicity; D006632:Histamine / Q000633:toxicity; D008297:Male; D009410:Nerve Degeneration; D009475:Neurons, Afferent / Q000187:drug effects / Q000473:pathology; D010455:Peptides / Q000633:toxicity*; D011112:Polymyxin B / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000187:drug effects / Q000473:pathology*; D013116:Spinal Cord / Q000187:drug effects / Q000473:pathology*
chemical_list: D005971:Glutamates; D010455:Peptides; D006632:Histamine; D011112:Polymyxin B; D003091:Colistin