Body core temperature and depression during total sleep deprivation in depressives.
Endogenously depressed patients were subjected to a total sleep deprivation (TSD) schedule of sleep-TSD-sleep-TSD. They were simultaneously treated with the antidepressant drug clomipramine. Self- and observer-rated depression was measured daily. Continuously measured rectal temperature (RT) data were available for the second TSD. It was found that a higher nocturnal minimum RT during this TSD was associated with a positive clinical response.
Elsenga
S
S
Department of Biological Psychiatry, University Psychiatric Clinic, Groningen, The Netherlands.
Van den Hoofdakker
R H
RH
D001833:Body Temperature Regulation / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects; D002997:Clomipramine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012892:Sleep Deprivation
D002997:Clomipramine