title: Gallium-67/technetium-99m methylene diphosphonate ratio imaging: early rabbit osteomyelitis and fracture.
abstract: Simultaneous digital acquisition of [67Ga] and [99mTc]MDP images, and subsequent division of the first by the second to produce a parametric ratio image (G/T), is employed to characterize the relative localization of the two radiopharmaceuticals in early rabbit tibia Staphloccocus aureus osteomyelitis and fracture repair. Images obtained during the first 48 hr of each condition show preferential 67Ga accumulation probably reflecting an initial inflammatory response while G/T images at 5-7 days show predominance of the bone-seeking scan agent, which may indicate that the dominant process is osteoblastic repair.
authors.forename: M F
authors.initials: MF
authors.lastname: Hartshorne
authors.forename: G
authors.initials: G
authors.lastname: Graham
authors.forename: J
authors.initials: J
authors.lastname: Lancaster
authors.forename: D
authors.initials: D
authors.lastname: Berger
mesh_terms: D000818:Animals; D004164:Diphosphonates; D005710:Gallium Radioisotopes; D010006:Osteoblasts / Q000502:physiology; D010019:Osteomyelitis / Q000000981:diagnostic imaging* / Q000209:etiology; D011817:Rabbits; D011877:Radionuclide Imaging; D013203:Staphylococcal Infections / Q000000981:diagnostic imaging*; D013667:Technetium; D013669:Technetium Tc 99m Medronate; D013978:Tibial Fractures / Q000000981:diagnostic imaging*; D013997:Time Factors; D014945:Wound Healing
chemical_list: D004164:Diphosphonates; D005710:Gallium Radioisotopes; D013667:Technetium; D013669:Technetium Tc 99m Medronate