Effects of desogestrel, levonorgestrel and lynestrenol on serum sex hormone binding globulin, cortisol binding globulin, ceruloplasmin and HDL-cholesterol.
The effects of 0.125 mg daily doses of the new progestagen, desogestrel, 0.125 mg of levonorgestrel or 5 mg of lynestrenol on serum sex hormone binding globulin (SHBG), cortisol binding globulin (CBG), ceruloplasmin and HDL-cholesterol were studied in 30 healthy female volunteers to compare the possible androgenic and oestrogenic effects of these contraceptive steroids in vivo. All the progestagens in the applied dosages decreased SHBG and HDL-cholesterol concentrations, suggesting some androgenicity. Lynestrenol increased ceruloplasmin and CBG concentrations, indicating weak oestrogenic effects of the steroid. During desogestrel treatments, CBG and ceruloplasmin concentrations remained unchanged. After 30 days treatment with levonorgestrel there was a slight decrease (P less than 0.05) in ceruloplasmin concentrations. Thirty days after finishing the progestagen treatments serum protein concentrations were normal. In conclusion, at the doses used and under the present test conditions the progestagens studied had a weak androgen-like effect and lynestrenol also showed weak oestrogenic activity, as determined by their effects on serum proteins.
Ruokonen
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Käär
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D000293:Adolescent; D000328:Adult; D002352:Carrier Proteins / Q000097:blood*; D002570:Ceruloplasmin / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood*; D002986:Clinical Trials as Topic; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D017135:Desogestrel; D005260:Female; D006801:Humans; D016912:Levonorgestrel; D008234:Lynestrenol / Q000494:pharmacology*; D009644:Norgestrel / Q000494:pharmacology*; D009652:Norpregnenes / Q000494:pharmacology*; D011897:Random Allocation; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*
D002352:Carrier Proteins; D008076:Cholesterol, HDL; D003277:Contraceptives, Oral, Combined; D009652:Norpregnenes; D012738:Sex Hormone-Binding Globulin; C027091:cortisol binding globulin; D009644:Norgestrel; D016912:Levonorgestrel; D017135:Desogestrel; D002570:Ceruloplasmin; D008234:Lynestrenol