Coronary sinus norepinephrine concentrations during ventricular tachycardia induced by left stellate ganglion stimulation in dogs.
Coronary sinus catecholamine overflow was measured in open-chest dogs, anesthetized with sodium thiopental and alpha-chloralose, during left sympathetic stimulation. Uniform ventricular tachycardias were induced in 9 out of 16 dogs during either left stellate ganglion or left ventrolateral cardiac nerve stimulations. Significant increases in norepinephrine (8.1 ng/mL, plasma) and epinephrine (0.19 ng/mL, plasma) overflows were obtained after 30 and 90 s of stimulation, respectively. Maximum norepinephrine overflow was significantly higher in dogs with ventricular tachycardia than in those without it (16.0 vs. 7.4 ng/mL, p less than 0.05). This suggests that the induction of ventricular tachycardia in the normal myocardium is related to the amount of local secretion of norepinephrine during nerve stimulation.
Nadeau
R
R
Centre de recherche, Hôpital du Sacré-Coeur de Montréal, Québec, Canada.
Lamontagne
D
D
Cardinal
R
R
de Champlain
J
J
Armour
J A
JA
D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D004566:Electrodes; D004837:Epinephrine / Q000097:blood; D005260:Female; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D012850:Sinus of Valsalva / Q000378:metabolism*; D013233:Stellate Ganglion / Q000502:physiology*; D013610:Tachycardia / Q000097:blood*
D009638:Norepinephrine; D004837:Epinephrine