Plasma beta-endorphin-like-immunoreactivity levels and hemodynamics in patients with septic shock.
Plasma beta-endorphin-like immunoreactivity (beta-ELIR) levels were measured during hyper and hypodynamic phases of septic shock in patients (n = 36) due to a variety of microorganisms. Plasma beta-ELIR levels were elevated in all groups, but were most marked in patients with hyperdynamic circulation due to gram-positive and gram-negative organisms, followed by hypodynamic circulation due to gram-negative organisms and were least elevated in hypodynamic shock due to gram-positive organisms. There was strong correlation between plasma beta-ELIR levels and cardiac index in patients with a hyperdynamic circulation (gram-negative organisms, rs = 0.79, p less than 0.01; gram-positive, rs = 0.85, p less than 0.01) but little to no correlation in patients with hypodynamic circulation (gram-negative, rs = 0.32, p = NS; gram-positive organisms rs = 0.04, p = NS). These results imply that plasma beta-ELIR levels may be involved in the early phases of septic shock and may contribute to a hyperdynamic circulation, whereas plasma beta-ELIR levels may be normal or may not be related to hypodynamic circulation as seen in later phases of shock.
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D001419:Bacteria / Q000302:isolation & purification; D004723:Endorphins / Q000097:blood* / Q000276:immunology; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology; D012772:Shock, Septic / Q000097:blood* / Q000382:microbiology / Q000503:physiopathology; D001615:beta-Endorphin
D004723:Endorphins; D009270:Naloxone; D001615:beta-Endorphin