The effect of sodium-2-mercaptoethane-sulphonate, N-acetylcysteine and cysteine on the uptake of cytosine arabinoside by normal and neoplastic thymus cells of mice.
The effect of some sulfhydryl compounds on the uptake of cytosine arabinoside (Ara-C) by normal and neoplastically transformed mouse thymus cells was studied. Sodium 2-mercaptoethanesulphonate (Mesna) was found to greatly inhibit (in 80%) the uptake of Ara-C by normal cells. Two other SH-compounds (cysteine and N-acetyl-cysteine) displayed no such effect. None of the three compounds reduced the uptake of Ara-C by neoplastic thymus cells. The possible pharmacological implications of these findings are discussed.
Jastrzebski
Z
Z
Department of Pharmacology, Institute of Drug Research and Control, Warsaw.
Danysz
A
A
Czyzewska-Szafran
H
H
Czarnomska
A
A
D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D003545:Cysteine / Q000494:pharmacology*; D003561:Cytarabine / Q000493:pharmacokinetics*; D005260:Female; D008297:Male; D008623:Mercaptoethanol / Q000031:analogs & derivatives*; D015080:Mesna / Q000494:pharmacology*; D051379:Mice; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism*; D013953:Thymus Neoplasms / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D003561:Cytarabine; D008623:Mercaptoethanol; D003545:Cysteine; D015080:Mesna; D000111:Acetylcysteine