title: Microbial spectrum of blood and body cultures in febrile episodes of children under chemotherapy for treatment of malignant diseases.
abstract: One hundred thirty-five febrile episodes in 111 children with malignancies were reviewed. In 50 of 125 episodes blood cultures were positive; gram-positive bacteremia was detected in 40 episodes and gram-negative bacteremia in 10 episodes. The predominant gram-positive bacteria were coagulase-negative staphylococci, the predominant gram-negative bacteria were Escherichia coli. The possible role of coagulase-negative staphylococci in causing septicemia in immunocompromised hosts is discussed with conclusions that influence designing a primary antibiotic regimen to treat febrile episodes in leukopenic children.
authors.affiliation: Universitäts-Kinderklinik Düsseldorf, Abteilung für Hämatologie und Onkologie, F.R.G.
authors.forename: V
authors.initials: V
authors.lastname: Göbel
authors.forename: H
authors.initials: H
authors.lastname: Jürgens
authors.forename: L
authors.initials: L
authors.lastname: Thomas
authors.forename: D
authors.initials: D
authors.lastname: Schwamborn
authors.forename: H
authors.initials: H
authors.lastname: Rosin
authors.forename: U
authors.initials: U
authors.lastname: Göbel
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001419:Bacteria / Q000302:isolation & purification*; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D001769:Blood / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D004755:Enterobacteriaceae / Q000302:isolation & purification; D005334:Fever / Q000150:complications / Q000382:microbiology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D007223:Infant; D009369:Neoplasms / Q000150:complications* / Q000382:microbiology; D018805:Sepsis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents