Keratoderma hereditaria mutilans (Vohwinkel's syndrome): a trial of isotretinoin.
An 8-year-old girl with the classic findings of keratoderma hereditaria mutilans (Vohwinkel's syndrome) was seen. Treatment with isotretinoin was instituted to decrease the hyperkeratosis and to prevent further autoamputation. After a 12-week course at 2 mg per kg per day, the patient had only minimal decrease in the amount of hyperkeratosis. Because of the well-known long-term risks of systematic retinoids and her suboptimal improvement, therapy was discontinued.
Goldfarb
M T
MT
Woo
T Y
TY
Rasmussen
J E
JE
D002648:Child; D005260:Female; D006801:Humans; D015474:Isotretinoin; D007645:Keratoderma, Palmoplantar / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000473:pathology; D014212:Tretinoin / Q000627:therapeutic use*
D014212:Tretinoin; D015474:Isotretinoin