title: [Urinary excretion of 3-methylhistidine. Value and application to the study of protein catabolism].
abstract: The urinary excretion of 3-methylhistidine (3 MH) is considered an easy and reliable method to quantify muscle protein catabolism in man. The 3 MH/creatinine (Cr) ratio is thought to be a good index of fractional degradation of muscle fibre protein. In the present article, the stress is placed on the limitations of 3 MH assays an- on their clinical applications. In thyroid diseases and in malnutrition (anorexia nervosa), the 3 MH/Cr ratio differentiates clearly marasmic malnutrition without increase in protein catabolism from hypercatabolic states, such as hyperthyroidism, with excessive protein degradation. 3 MH measurements therefore appear to be useful to determine the contribution of protein catabolism to lean mass reduction.
authors.forename: J L
authors.initials: JL
authors.lastname: Richard
authors.forename: M
authors.initials: M
authors.lastname: Rodier
authors.forename: J
authors.initials: J
authors.lastname: Bringer
authors.forename: G
authors.initials: G
authors.lastname: Cavalie
authors.forename: M
authors.initials: M
authors.lastname: Claustres
authors.forename: H
authors.initials: H
authors.lastname: Bellet
authors.forename: J
authors.initials: J
authors.lastname: Mirouze
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000856:Anorexia Nervosa / Q000652:urine*; D002648:Child; D003404:Creatinine / Q000652:urine; D003920:Diabetes Mellitus / Q000652:urine*; D005260:Female; D006639:Histidine / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008762:Methylhistidines / Q000652:urine*; D008875:Middle Aged; D009124:Muscle Proteins / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism; D051381:Rats; D013959:Thyroid Diseases / Q000652:urine*
chemical_list: D008762:Methylhistidines; D009124:Muscle Proteins; D006639:Histidine; D003404:Creatinine
vernacular_title: L'excrétion urinaire de 3-méthylhistidine. Intérêt et application dans l'étude du catabolisme protidique.