Regrafts.
1. One-year patient survival rates improved markedly year by year for regrafted kidney patients reaching 93% in 1986, as compared with 96% in first grafts. 2. The graft survival rate of regrafts also showed steady improvement, but was not benefited by the introduction of CsA as much as in first grafts. One-year graft survival rate was 63% for regrafts in 1986. 3. The functional graft survival was higher with advancing recipient age in first grafts, but remained essentially constant regardless of age in regrafts. We interpret this to mean that older patients have depressed immunologic capability to reject first grafts, but those immunized patients by rejecting a first graft have undiminished reactivity. 4. A high graft survival rate of 68% at one-year was observed for patients who had been sensitized before their first transplant but lost their antibodies before the second transplant. One-year graft survival of those who were not sensitized before both first and second grafts was 60%. 5. The duration of first grafts significantly influences the outcome of second grafts (p less than 0.00001). The highest graft survival was obtained in recipients who had functioning first grafts for more than 2 years (69% at one year), followed by those for recipients whose grafts had functioned for one to 2 years, 6-12 months, and 3-6 months. Patients who lost their first grafts within 3 months had the lowest graft survival rate (44% at one year). 6. The time interval had an influence on the outcome of second grafts.(ABSTRACT TRUNCATED AT 250 WORDS)
Iwaki
Y
Y
Cho
R Y
RY
Terasaki
P I
PI
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006085:Graft Survival; D006680:HLA Antigens; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology* / Q000401:mortality / Q000706:statistics & numerical data; D008875:Middle Aged; D012086:Reoperation
D006680:HLA Antigens