title: Acute leukemia characterized by trisomy 8 in Down's syndrome.
abstract: Of the myeloproliferative disorders which develop in Down's syndrome, acute leukemia associated with trisomy 8 has distinct characteristics. It is non-lymphoblastic in type and has a preleukemia phase in which thrombocytopenia is a prominent feature. One case occurring in a 20 mth-old girl is reported and 3 other similar cases reviewed. Acquired trisomy 8 in Down's syndrome is linked to leukemogenesis and confers non-lymphoblastic differentiation.
authors.forename: A F
authors.initials: AF
authors.lastname: Broomhead
authors.forename: Y L
authors.initials: YL
authors.lastname: Kwan
authors.forename: N A
authors.initials: NA
authors.lastname: Zell
authors.forename: P R
authors.initials: PR
authors.lastname: Lam-Po-Tang
authors.forename: D
authors.initials: D
authors.lastname: O'Gorman Hughes
mesh_terms: D002906:Chromosomes, Human, 6-12 and X; D004314:Down Syndrome / Q000150:complications* / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007938:Leukemia / Q000150:complications* / Q000235:genetics; D014314:Trisomy