[Photodynamic effect of chlorine e6 on erythrocyte membranes].
Photodestruction of erythrocyte membranes sensitized by water soluble chlorophyll derivative chlorine e6 (Chl e6) was studied. It has been determined that light irradiation of erythrocyte ghosts with wave length lambda-660 nm in the presence of Chl e6 caused in protein and lipid components of the membrane deep destructive changes which were expressed in cross-linking of the membrane polypeptides and accumulating in the membrane products of peroxidation of unsaturated fatty acids residues, in phospholipids mainly. It has been shown that these processes were realized only in the presence of molecular oxygen and consequently possess pure photodynamic character.
Kochubeev
G A
GA
Frolov
A A
AA
Kostiuk
V A
VA
Pronskaia
I V
IV
Gurinovich
G P
GP
D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D066298:In Vitro Techniques; D015227:Lipid Peroxidation; D008563:Membrane Lipids / Q000378:metabolism; D010778:Photochemotherapy; D011166:Porphyrins / Q000494:pharmacology*
D008563:Membrane Lipids; D011166:Porphyrins; C006969:chlorin
Fotodinamicheskoe deĭstvie khlorina e6 na membrany éritrotsitov.