Heterochromatic variants and their association with neoplasias: IV. Colon adenomas and carcinomas.
C-band polymorphisms in peripheral blood lymphocytes of 62 patients (33 with colon adenomas and 29 with colon carcinomas) were studied. A significant difference in the frequency of heterochromatic variants in chromosomes #1 in both colon adenoma (56%) and carcinoma (67%) with respect to controls (18%) was observed (p less than 0.001). The heterochromatic variants preferentially involved in both pathologies were inv(1), 1qh-, and inv(9), compared with controls. No differences were found between colon adenomas and carcinomas. We suggest that 1qh- and inv(1) variants are important heterochromatic changes in neoplasia.
Labal de Vinuesa
M
M
Centro Austral de Investigaciones Cientificas (CADIC), Tierra del Fuego, Argentina.
Mudry de Pargament
M
M
Slavutsky
I
I
Meiss
R
R
Chopita
N
N
Larripa
I
I
D000236:Adenoma / Q000235:genetics*; D002277:Carcinoma / Q000235:genetics*; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D002899:Chromosomes, Human, Pair 9; D003110:Colonic Neoplasms / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D011110:Polymorphism, Genetic
D005819:Genetic Markers