title: Corneal endothelial polymegathism after the extended wear of rigid gas-permeable contact lenses.
abstract: To determine if there are any corneal endothelial cell size and shape changes in subjects wearing rigid gas-permeable contact lenses for cosmetic extended wear, six unadapted lens wearers were fitted using four different lens materials. Each subject wore one lens extended-wear and the other daily-wear for 3 months. Before lens wear and after 3 months, noncontact endothelial photographs were taken. Cell tracings were analyzed by a digitizing computer. This study showed significant endothelial polymegathism, an increase in maximum cell area to minimum cell area, and a significant decrease in percent frequency of hexagonal cells in the extended-wear eyes. There existed in these subjects a significant correlation between changes in cell size (polymegathism) and cell shape (pleomorphism).
authors.affiliation: Bausch & Lomb, Inc., Rochester, New York.
authors.forename: G N
authors.initials: GN
authors.lastname: Orsborn
authors.forename: J P
authors.initials: JP
authors.lastname: Schoessler
mesh_terms: D000328:Adult; D003262:Contact Lenses, Extended-Wear / Q000009:adverse effects*; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male