Potentiation of tyramine pressor responses in conscious rats by reversible inhibitors of monoamine oxidase.
Intraperitoneal injection of cimoxatone, moclobemide, amiflamine CGP 11305 A (all 5 mg/kg) increased pressor responses to intravenous tyramine (100 micrograms) in conscious, freely moving rats. Area under mean arterial pressure curve increased by 7.01, 4.28, 5.3 and 3.46 fold respectively. Clorgyline (2 mg/kg) increased area under pressor response curve by 10.4 fold. Tyramine responses returned to normal 24 hours after reversible inhibitors but were still potentiated 24 hours after clorgyline.
Finberg
J P
JP
Rappaport Family Institute of Medical Research, Technion, Haifa, Israel.
Youdim
M B
MB
D000818:Animals; D001549:Benzamides / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects*; D003010:Clorgyline / Q000633:toxicity; D004357:Drug Synergism; D008297:Male; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage / Q000633:toxicity*; D010080:Oxazoles / Q000633:toxicity; D023303:Oxazolidinones; D010627:Phenethylamines / Q000633:toxicity; D010880:Piperidines / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D014439:Tyramine / Q000008:administration & dosage / Q000633:toxicity*
D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D010080:Oxazoles; D023303:Oxazolidinones; D010627:Phenethylamines; D010880:Piperidines; C038213:brofaromine; D003010:Clorgyline; C031466:amiflamine; D020912:Moclobemide; C026234:cimoxatone; D014439:Tyramine