title: Non-thiol-activated cytolytic bacterial toxins: current status.
abstract: Among non-thiol-activated cytolytic toxins, staphylococcal alpha-toxin, staphylococcal leucocidin, and pseudomonal leucocidin are characterized by their interaction (with susceptible cell membranes) as a biomembrane response modifier. The transmembrane signalling by the receptor-toxin complex follows the activities of membrane-associated enzymes, which lead to changes in membrane ion-permeability.
authors.affiliation: Department of the Second Microbiology, School of Medicine, Chiba University, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kato
authors.forename: N
authors.initials: N
authors.lastname: Morinaga
authors.forename: R
authors.initials: R
authors.lastname: Muneto
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity*; D002462:Cell Membrane / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects; D006460:Hemolysin Proteins / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity*; D007956:Leukocidins / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity*; D007962:Leukocytes / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000032:analysis; D011817:Rabbits; D013211:Staphylococcus aureus / Q000032:analysis
chemical_list: D001427:Bacterial Toxins; D006460:Hemolysin Proteins; D007956:Leukocidins; C021091:staphylococcal alpha-toxin