title: [Azoles. 18. Sulfonylindazole derivatives].
abstract: The nucleophilic substitution of hydrogen to synthesize the sulphonyl indazole derivatives 9-16 is described. The structures of the substitution products are discussed using H-NMR spectra. Chemical structural proof was given by steric hindrance observed in the process of chorination of 9-16. The compounds 3, 4, 7, 8, 14, and 16 are studied to find an inhibition on phospholipase-A2 and lipoxygenase-I.
authors.affiliation: Lehrstuhl für Organische Chemie der Karol Marcinkowski Medizinischen Akademie, Poznań, VR Polen.
authors.forename: J
authors.initials: J
authors.lastname: Dudzińska-Usarewicz
authors.forename: U
authors.initials: U
authors.lastname: Wrzeciono
authors.forename: A
authors.initials: A
authors.lastname: Frankiewicz
authors.forename: E
authors.initials: E
authors.lastname: Linkowska
authors.forename: T
authors.initials: T
authors.lastname: Köhler
authors.forename: P
authors.initials: P
authors.lastname: Nuhn
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D001393:Azoles / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007191:Indazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors; D009682:Magnetic Resonance Spectroscopy; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D054467:Phospholipases A2; D011720:Pyrazoles / Q000138:chemical synthesis*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001393:Azoles; D007191:Indazoles; D016859:Lipoxygenase Inhibitors; D011720:Pyrazoles; D010741:Phospholipases A; D054467:Phospholipases A2
vernacular_title: Azole. 18. Mitteilung: Sulfonylindazolderivate.