A novel form of GD1c ganglioside IV3 (NeuAc alpha 2-8 NeuGc)Gg4Cer from murine X-ray induced thymoma.
Four disialoganglioside fractions were isolated from X-ray induced thymoma in C57Bl/6 mice. On the basis of compositional and methylation analyses as well as degradation with specific exoglycosidases a novel form of GD1c ganglioside NeuAc alpha 2-8 NeuGc alpha 2-3 Gal beta 1-3 GalNAc beta 1-4 Gal beta 1-4 GlcCer was identified.
Pacuszka
T
T
Department of Biochemistry, Institute of Hematology, Warszawa, Poland.
Antoniewicz
J
J
D000818:Animals; D002855:Chromatography, Thin Layer; D005732:Gangliosides / Q000302:isolation & purification*; D006026:Glycoside Hydrolases / Q000378:metabolism; D008745:Methylation; D051379:Mice; D015394:Molecular Structure; D009381:Neoplasms, Radiation-Induced / Q000032:analysis*; D009439:Neuraminidase / Q000378:metabolism; D013945:Thymoma / Q000032:analysis* / Q000209:etiology; D013953:Thymus Neoplasms / Q000032:analysis* / Q000209:etiology
D005732:Gangliosides; C059628:(N-acetylneuraminosyl-(2--8)-N-glycolylneuraminic acid)gangliotetraosylceramide; D006026:Glycoside Hydrolases; D009439:Neuraminidase