title: Uptake of acetylated LDL by peritoneal macrophages obtained from normal and Watanabe heritable hyperlipidemic rabbits, an animal model for familial hypercholesterolemia.
abstract: Acetylated low-density lipoprotein (acetyl-LDL) stimulated the incorporation of [14C]oleate into cholesteryl [14C]oleate in peritoneal macrophages from both normal and Watanabe heritable hyperlipidemic (WHHL) rabbits. A degradation study showed that macrophages from WHHL rabbits degraded the same amount of 125I-labeled acetyl-LDL as macrophages from normal rabbits. These findings indicate that macrophages of WHHL rabbits have functional acetyl-LDL receptors.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: T
authors.initials: T
authors.lastname: Kita
authors.forename: N
authors.initials: N
authors.lastname: Kume
authors.forename: Y
authors.initials: Y
authors.lastname: Nagano
authors.forename: C
authors.initials: C
authors.lastname: Kawai
mesh_terms: D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D015815:Cell Adhesion Molecules; D002478:Cells, Cultured; D002788:Cholesterol Esters / Q000096:biosynthesis; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000235:genetics* / Q000378:metabolism; D006938:Hyperlipoproteinemia Type II; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D011817:Rabbits; D011973:Receptors, LDL / Q000378:metabolism; D051116:Receptors, Scavenger
chemical_list: D015815:Cell Adhesion Molecules; D002788:Cholesterol Esters; D008077:Lipoproteins, LDL; D011973:Receptors, LDL; D051116:Receptors, Scavenger; C032629:acetyl-LDL; C014409:cholesteryl oleate