Concanavalin-A-activated lymphocytes suppress immune responses in vitro but are helper cells in vivo.
In vitro concanavalin A (Con A)-activated spleen cells suppressed the primary in vitro immune response of syngeneic spleen cells to sheep erythrocytes (SRBC) but enhanced the in vivo anti-SRBC responses when transferred to syngeneic untreated mice. Con-A-activated spleen cells injected into nude mice enabled these mice to respond to SRBC.
Möller
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D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D013154:Spleen / Q000166:cytology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D003208:Concanavalin A