[Interaction in vitro of nicotinamide and diethylnicotinamid (cordiamine) with enzymes of the liver microsomal hydoxylating system in the rat].
Addition of nicotinamide and diethylnicotinamide (cordiamine) to rat liver microsomes leads to the formation of an enzyme-substrate Type II complex with cytochrome P-450. Diethylnicotinamide exceeded nicotinamide approximately 2-fold as regards the degree of the affinity to the enzyme. The ability of nicotinamide and diethylnicotinamide to interact with cytochrome P-450 underlies their antagonism with respect to in-vitro metabolism of the substrates of both Type I (amidopyrine) and Type II (aniline) as well as with respect to the competition with CO for the common center of binding on the enzyme.
Bushma
M I
MI
Lukienko
P I
PI
D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions; D004579:Electron Transport / Q000187:drug effects; D005260:Female; D006900:Hydroxylation; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D009536:Niacinamide / Q000494:pharmacology*; D009552:Nikethamide / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats
D000814:Aniline Compounds; D000632:Aminopyrine; D009536:Niacinamide; D009552:Nikethamide; D003577:Cytochrome P-450 Enzyme System; D009247:NADH, NADPH Oxidoreductases; C023650:aniline
Vzaimodeĭstvie in vitro nikotinamida i diétilnikotinamida (kordiamina) s fermentami gidroksiliruiushcheĭ sistemy mikrosom pecheni krys.