title: [Intrafamilial renal transplantation in children after donor blood transfusions].
abstract: This article represents an update of our experience with deliberate donor specific blood transfusions (D.S.T.) prior to living-related renal transplantation in children. Eighteen recipients with a negative cross- match to donor T and B cells entered the D.S.T. protocol without regard to the results of the mixed lymphocyte cultures and third party transfusion. The D.S.T. procedure involves the administration of fresh packed cells on 2 or 3 separate occasions at 4 weeks intervals. The potential recipient's sensitization is closely monitored against donor's isolated T and B lymphocytes and against a random panel. This immunological monitoring is done 10 to 20 days after each D.S.T. and just prior to grafting. A negative T and B cross-match at 37 degrees C is a pre-requisite for transplantation. Sixteen patients have been transplanted. All kidneys are functioning with follow-ups ranging from 6 to 48 months; 10 patients have normal renal function, 2 of them experienced reversible acute rejection and 6 have chronic rejection. The benefits derived from pretransplant D.S.T. in parental renal transplantation appear to be substantial, although the nature of the various immunological mechanisms remains unclear.
authors.forename: C
authors.initials: C
authors.lastname: Kaplan
authors.forename: P
authors.initials: P
authors.lastname: Niaudet
authors.forename: M F
authors.initials: MF
authors.lastname: Gagnadoux
authors.forename: J L
authors.initials: JL
authors.lastname: Bacri
authors.forename: M F
authors.initials: MF
authors.lastname: Reznikoff
authors.forename: J Y
authors.initials: JY
authors.lastname: Muller
authors.forename: M
authors.initials: M
authors.lastname: Broyer
mesh_terms: D000293:Adolescent; D001803:Blood Transfusion / Q000379:methods; D002648:Child; D002675:Child, Preschool; D005190:Family; D006082:Graft Enhancement, Immunologic; D006801:Humans; D016030:Kidney Transplantation; D007959:Lymphocyte Culture Test, Mixed; D011446:Prospective Studies; D013997:Time Factors
vernacular_title: Transplantation rénale intrafamiliale chez l'enfant après transfusions du sang du donneur.