Lung and cervical lymph-node metastasis after cortisone enhancement in hamster cheek-pouch carcinogenesis.
The administration of hydrocortisone after excision of DMBA-induced tumours in hamster cheek pouch produced cervical lymph-node metastases in 9 out of 13 animals (69 per cent), and resulted in lung metastasis in 1 animal. In the control group, which received no cortisone but had tumours cut from the pouch, 4 out of 9 animals had cervical lymph-node metastases (44 per cent).
Kage
T
T
Department of Oral & Maxillofacial Surgery I, Matsumoto Dental College, Nagano, Japan.
Mogi
M
M
Katsumata
Y
Y
Yamada
T
T
Chino
T
T
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology*; D002610:Cheek; D006224:Cricetinae; D004195:Disease Models, Animal; D006258:Head and Neck Neoplasms / Q000556:secondary*; D006854:Hydrocortisone / Q000633:toxicity*; D008175:Lung Neoplasms / Q000556:secondary*; D008207:Lymphatic Metastasis / Q000473:pathology*; D008647:Mesocricetus; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000473:pathology*
D015127:9,10-Dimethyl-1,2-benzanthracene; D006854:Hydrocortisone