Direct demonstration of production of transforming growth factor activity by embryonic chick tissue.
The presence of transforming growth factor activity in early chick embryos was directly demonstrated by the ability of limb and tail buds to induce anchorage independent division in NRK 49 f cells. Colony number increased with limb bud number and developmental stage. Medium conditioned by tail buds contained some stimulating effect, and strongly promoted the action of other transforming growth factors.
McLachlan
J C
JC
Department of Biology and Preclinical Medicine, University of St. Andrews, Scotland.
Macintyre
J
J
Hume
D D
DD
Smith
J
J
D000818:Animals; D002642:Chick Embryo; D046508:Culture Techniques; D005121:Extremities / Q000196:embryology / Q000378:metabolism; D010452:Peptide Biosynthesis; D013623:Tail / Q000196:embryology / Q000378:metabolism; D013997:Time Factors; D015291:Transforming Growth Factors
D015291:Transforming Growth Factors