Antagonism by lisuride and 8-OH-DPAT of 5-HTP-induced prolongation of the performance of male rat sexual behavior.
Both lisuride and 8-OH-DPAT dose dependently antagonized the 5-HTP-induced inhibition of male rat sexual behavior. The increase in the number of intromissions and/or the ejaculation latency produced by 5-HTP, 25 mg/kg i.p. (-60 min) in combination with the peripheral 5-HTP decarboxylase inhibitor benserazide, 25 mg/kg i.p. (-90 min), were antagonized by lisuride, 0.05-0.1 mg/kg i.p. (-15 min) and by 8-OH-DPAT, 0.025-0.05 mg/kg i.p. (-15 min). Thus, in this model lisuride and 8-OH-DPAT behave as 5-HT antagonists.
Ahlenius
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S
Larsson
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K
D006916:5-Hydroxytryptophan / Q000037:antagonists & inhibitors*; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D004873:Ergolines / Q000494:pharmacology*; D008090:Lisuride / Q000494:pharmacology*; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D004873:Ergolines; D009281:Naphthalenes; D013764:Tetrahydronaphthalenes; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D006916:5-Hydroxytryptophan; D008090:Lisuride