title: Identification and control of paratuberculosis in a large goat herd.
abstract: Mycobacterium paratuberculosis infection was detected in 2 goats in 1974 and in 5 goats in 1975; 5 of which were from a single herd. The magnitude of the subsequent epizootic in the goat herd was not recognized until 1977, when results of bacteriologic culture of fecal and tissue specimens, antibody determinations (agar-gel immuno-diffusion test), and histopathologic studies became available. By 1984, paratuberculosis had been diagnosed in 124 goats. Nearly all the goats were being used in antiserum production and had been given Freund complete adjuvant and human antigens. From 1974 to 1986, herd size varied from 100 to 300. The yearly incidence of paratuberculosis decreased from 13.2% (27 of 204 goats) in 1977 to 0% in 108 goats in 1985. The prevalence was higher in does. In goats that arrived on the farm in 1975 and before, 49 of 121 (40.5%) does developed paratuberculosis vs 41 of 120 (34.2%) wethers. In goats arriving on the farm in 1976 and after, 25 of 274 (8.5%) does and 9 of 216 (4.1%) wethers developed paratuberculosis. The average incubation period was approximately 4 years from arrival on the farm in every year except 1978, regardless of whether the goat was born on the farm or was purchased elsewhere.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Atlantic Antibodies Inc., Windham, ME 04062.
authors.forename: H M
authors.initials: HM
authors.lastname: Gezon
authors.forename: H D
authors.initials: HD
authors.lastname: Bither
authors.forename: H C
authors.initials: HC
authors.lastname: Gibbs
authors.forename: E J
authors.initials: EJ
authors.lastname: Acker
authors.forename: L A
authors.initials: LA
authors.lastname: Hanson
authors.forename: J K
authors.initials: JK
authors.lastname: Thompson
authors.forename: R D
authors.initials: RD
authors.lastname: Jorgenson
mesh_terms: D000818:Animals; D004196:Disease Outbreaks / Q000662:veterinary*; D004977:Ethambutol / Q000627:therapeutic use; D005260:Female; D006041:Goats; D005779:Immunodiffusion; D007538:Isoniazid / Q000627:therapeutic use; D008297:Male; D010283:Paratuberculosis / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control*; D012293:Rifampin / Q000627:therapeutic use; D012737:Sex Factors; D015431:Weight Loss
chemical_list: D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin