Induction of an allergic reaction to alcohol metabolites by immunization.
Acetaldehyde, a product of alcohol metabolism, is known to bind covalently to plasma and red cell proteins, yielding stable adducts which have recently shown are recognized as foreign by the immune system. The present study demonstrates that immunization of mice with protein-acetaldehyde adducts in aluminum hydroxide gel results in the production of reaginic antibodies that recognize the adducts and trigger an allergic-anaphylactic reaction. These findings may lead to new approaches in the treatment of excessive alcohol consumption in humans.
Israel
Y
Y
Departments of Pharmacology, University of Toronto, Ontario, Canada.
MacDonald
A
A
Waks
T
T
Niemelä
O
O
D000079:Acetaldehyde / Q000009:adverse effects* / Q000097:blood / Q000276:immunology; D000437:Alcoholism / Q000628:therapy; D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors; D000818:Animals; D003484:Cyanamide / Q000494:pharmacology; D004221:Disulfiram / Q000494:pharmacology; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D007114:Immunization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats
D003484:Cyanamide; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde; D004221:Disulfiram