Production of auto-anti-idiotype antibody during the normal immune response. XI. Ficoll-induced variations in auto-anti-idiotype production during the response to 2,4,6-trinitrophenyl-Ficoll.
The responses to 2,4,6-trinitrophenyl conjugates of different Ficoll preparations differ with respect to the magnitude of the accompanying auto-anti-idiotype (Id) response in both mice and chickens. Evidence is presented that reduced auto-anti-Id production in the chicken is due to the activation of suppressor activity by some preparations of Ficoll.
Bhogal
B S
BS
Goidl
E A
EA
Jacobson
E B
EB
Gibbons
J J
JJ
Thorbecke
G J
GJ
Siskind
G W
GW
D000818:Animals; D000921:Antibody-Producing Cells / Q000378:metabolism; D001323:Autoantibodies / Q000096:biosynthesis*; D002645:Chickens; D005362:Ficoll / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000276:immunology* / Q000494:pharmacology; D006241:Haptens / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007700:Kinetics; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009578:Nitrobenzenes / Q000276:immunology*; D011134:Polysaccharides / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014301:Trinitrobenzenes / Q000008:administration & dosage / Q000276:immunology* / Q000494:pharmacology
D001323:Autoantibodies; D006241:Haptens; D007130:Immunoglobulin Idiotypes; D007166:Immunosuppressive Agents; D009578:Nitrobenzenes; D011134:Polysaccharides; C020529:TNP-ficoll; D014301:Trinitrobenzenes; D005362:Ficoll