Correlation among plasma osteocalcin, growth hormone, and somatomedin C in acromegaly.
Plasma osteocalcin (BGP), growth hormone (GH), and somatomedin C(SmC) were measured in 12 patients with acromegaly [7 clinically active (aA), 5 cured (cA)] and 9 control subjects (C). Basal plasma values for the three parameters were higher in aA than in C and in cA. No significant difference was found between cA and C. A significant linear correlation between BGP and GH and between BGP and SmC was obtained. These results suggest an effect of GH on BGP synthesis, possibly mediated by SmC, although a direct effect of GH on bone cannot be excluded.
de la Piedra
C
C
Unidad Metabólica, Fundación Jimenez Díaz, Madrid, Spain.
Larrañaga
J
J
Castro
N
N
Horcajada
C
C
Rapado
A
A
Herrera Pombo
J L
JL
Carbó
E
E
D000172:Acromegaly / Q000097:blood* / Q000473:pathology; D002135:Calcium-Binding Proteins / Q000097:blood*; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin; D013002:Somatomedins / Q000097:blood*
D002135:Calcium-Binding Proteins; D013002:Somatomedins; D015675:Osteocalcin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone