title: Ciprofloxacin disk susceptibility tests: interpretive zone size standards for 5-microgram disks.
abstract: Evaluations of 5-microgram ciprofloxacin disk diffusion susceptibility tests were performed independently by seven different investigators. The results of the separate tests were combined to increase the number of resistant strains in the challenge set of microorganisms. Based on data with 2,652 isolates, the following interpretive breakpoints are tentatively proposed for use in ongoing clinical trials of ciprofloxacin: less than or equal to 15 mm, resistant (MIC greater than 2.0 micrograms/ml); 16 to 20 mm, intermediate (1.0 less than MIC less than or equal to 2.0 micrograms/ml); and greater than or equal to 21 mm, susceptible (MIC less than or equal to 1.0 micrograms/ml). Disk tests with Streptococcus spp. and with Pseudomonas maltophilia were not reliable; other microorganisms were accurately categorized by the disk diffusion test.
authors.forename: A L
authors.initials: AL
authors.lastname: Barry
authors.forename: R J
authors.initials: RJ
authors.lastname: Fass
authors.forename: J P
authors.initials: JP
authors.lastname: Anhalt
authors.forename: H C
authors.initials: HC
authors.lastname: Neu
authors.forename: C
authors.initials: C
authors.lastname: Thornsberry
authors.forename: R C
authors.initials: RC
authors.lastname: Tilton
authors.forename: B G
authors.initials: BG
authors.lastname: Painter
authors.forename: J A
authors.initials: JA
authors.lastname: Washington
mesh_terms: D000150:Acinetobacter / Q000187:drug effects; D002939:Ciprofloxacin; D004755:Enterobacteriaceae / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests / Q000592:standards*; D011549:Pseudomonas / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
chemical_list: D011804:Quinolines; D002939:Ciprofloxacin