title: Potential prodrugs of phenelzine: N2-acetylphenelzine and N2-ethoxycarbonylphenelzine.
abstract: This report describes experiments conducted to determine whether simple monoacylated analogues of phenelzine might act as prodrug sources of phenelzine in vivo. The data suggest that hydrolysis to phenelzine may vary between analogues and that not all analogues retain the pharmacological properties of phenelzine.
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
authors.forename: T J
authors.initials: TJ
authors.lastname: Danielson
authors.forename: R T
authors.initials: RT
authors.lastname: Coutts
authors.forename: G B
authors.initials: GB
authors.lastname: Baker
authors.forename: M C
authors.initials: MC
authors.lastname: Chan
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008996:Monoamine Oxidase Inhibitors; D009043:Motor Activity / Q000187:drug effects; D010624:Phenelzine / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D011355:Prodrugs
chemical_list: D008996:Monoamine Oxidase Inhibitors; D011355:Prodrugs; C043198:N-acetylphenelzine; C057281:N(2)-ethoxycarbonylphenelzine; D010624:Phenelzine