title: Water proton NMR relaxation mechanisms in lung tissue.
abstract: The NMR relaxation times T'2, T2, and T1 were measured in isolated rat lungs as functions of external magnetic field B0, temperature, and lung inflation. The observed linear dependence on B0 of the tissue-induced free induction decay rate (T'2)-1 provides independent confirmation of the air/water interface model of the lung. Furthermore, measurements of the Larmor frequency dependence of T1 are consistent with a spin-lattice relaxation rate of the form 1/T1 = A omega -1/2 + B as expected for the case in which the relaxation arises from water-biopolymer cross-relaxation, which should be proportional to the surface area of the lung. This prediction was verified by observations of an approximately linear dependence of 1/T1 on transpulmonary pressure and thus on the lung surface area.
authors.affiliation: J. Stefan Institute, E. Kardelj University of Ljubljana, Yugoslavia.
authors.forename: M
authors.initials: M
authors.lastname: Kveder
authors.forename: I
authors.initials: I
authors.lastname: Zupancic
authors.forename: G
authors.initials: G
authors.lastname: Lahajnar
authors.forename: R
authors.initials: R
authors.lastname: Blinc
authors.forename: D
authors.initials: D
authors.lastname: Suput
authors.forename: D C
authors.initials: DC
authors.lastname: Ailion
authors.forename: K
authors.initials: K
authors.lastname: Ganesan
authors.forename: C
authors.initials: C
authors.lastname: Goodrich
mesh_terms: D000818:Animals; D001834:Body Water / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D011312:Pressure; D051381:Rats; D011919:Rats, Inbred Strains; D013696:Temperature