Haemolytic uraemic syndrome and pseudomembranous colitis.
Two cases of haemolytic uraemic syndrome (HUS) associated with pseudomembranous colitis (PMC) are described. The toxin of Clostridium difficile was detected post mortem in the stool of one patient and the other patient showed a good therapeutic response to oral vancomycin, an antibiotic with established efficacy in the management of PMC. When associated with HUS, PMC is probably an independent specific disease that, in common with many other infections, may activate HUS.
Rooney
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Department of Pathology, Bristol Royal Infirmary, UK.
Variend
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Taitz
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LS
D001426:Bacterial Proteins; D001427:Bacterial Toxins / Q000302:isolation & purification*; D002648:Child; D003013:Clostridium / Q000472:pathogenicity; D003015:Clostridium Infections / Q000150:complications; D004761:Enterocolitis, Pseudomembranous / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007223:Infant
D001426:Bacterial Proteins; D001427:Bacterial Toxins; C031815:toxB protein, Clostridium difficile