title: What causes uptake of technetium-99m methylene diphosphonate by tumors? A case where the tumor appeared to secrete a hypercalcemia-causing substance.
abstract: A patient exhibited an unusual constellation of findings: His extraosseous lymphoma sequestered [99mTc]MDP, a bone-seeking agent, while at the same time it appeared to produce a factor that caused hypercalcemia. The dispersed lymphoma cells took up more [99mTc]MDP in vitro than did cultured lymphoblasts suggesting that the in vivo sequestration may have been, at least in part, an active intracellular process.
authors.forename: C K
authors.initials: CK
authors.lastname: Stone
authors.forename: J C
authors.initials: JC
authors.lastname: Sisson
mesh_terms: D002478:Cells, Cultured; D004164:Diphosphonates; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D008214:Lymphocytes / Q000378:metabolism; D008223:Lymphoma / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013667:Technetium; D013669:Technetium Tc 99m Medronate; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D004164:Diphosphonates; D013671:Technetium Tc 99m Sulfur Colloid; D013667:Technetium; D013669:Technetium Tc 99m Medronate