Regulation of immune response by preadministration of cells briefly pulsed with antigen in vitro. III. Functional change of antigen presenting cells.
An intravenous administration of syngeneic spleen cells (SPCs) caused the reduction of antigen presenting activity of splenic adherent cells (SACs). The antigen presenting activity of SACs was reduced 10 days after the intravenous injection of 5 X 10(7) antigen pulsed or antigen nonpulsed SPCs. In contrast, when mice were immunized 5 days after the intravenous injection of SPCs, antigen presenting activity was reduced in the mice injected with antigen pulsed SPCs, and not in the mice injected with antigen nonpulsed SPCs. This reduction was recovered by the administration of cyclophosphamide 3 days before the injection of antigen pulsed SPCs, suggesting that suppressor T cells played an important role in the reduction of antigen presenting activity.
Hara
M
M
Yokomuro
K
K
Mabuchi
A
A
Kimura
Y
Y
D000818:Animals; D000917:Antibody Formation; D000938:Antigen-Presenting Cells / Q000276:immunology*; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D006433:Hemocyanins / Q000008:administration & dosage*; D007114:Immunization; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D013154:Spleen / Q000166:cytology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects
D003520:Cyclophosphamide; D006433:Hemocyanins