title: Mebendazole for worming mice: effectiveness and side effects.
abstract: The use of mebendazole-treated diet (60 ppm) effectively controlled Hymenolepis nana and Aspiculuris tetraptera in a large mouse breeding colony. In a 3 generation pilot study using a medicated diet, there was some reduction in litter size and in female growth rate and an overall 2.07% incidence of kinky tails in the offspring. When the whole mouse colony was fed mebendazole-treated diet, a high incidence of kinky tails (maximum 46% of weaned offspring) occurred.
authors.affiliation: Chemical Defence Establishment, Salisbury, Wiltshire, UK.
authors.forename: M
authors.initials: M
authors.lastname: Baskerville
authors.forename: M
authors.initials: M
authors.lastname: Wood
authors.forename: C M
authors.initials: CM
authors.lastname: Newton
mesh_terms: D000014:Abnormalities, Drug-Induced; D000818:Animals; D005260:Female; D006925:Hymenolepiasis / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D008463:Mebendazole / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects; D013623:Tail / Q000002:abnormalities
chemical_list: D008463:Mebendazole