13-cis-Retinoic acid and tetracycline versus 13-cis-retinoic acid alone in the treatment of nodulocystic acne.
A comparative clinical study on therapy of nodulocystic acne with 13-cis-retinoic acid was performed in 32 patients. 20 patients were treated with a dose of 1 mg/kg body weight daily, and 12 with a combined therapy: 0.25 mg/kg/day 13-cis-retinoic acid and 0.5 g of tetracycline daily. In both groups the therapy was carried out for 16 weeks. The effect of the combined therapy within 4 months was favourable in 75% of the cases versus 100% in the group treated with larger doses of 13-cis-retinoic acid. Thus, the time needed for clearing was longer in some patients (up to 6 months). However, the incidence of side effects was considerably lower in the group of combined therapy. In acne fulminans 13-cis-retinoic acid alone is not effective and should be combined with corticosteroids.
Langner
A
A
Wolska
H
H
Fraczykowska
M
M
Jablonska
S
S
Majewski
S
S
D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015474:Isotretinoin; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D013752:Tetracycline / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors; D014212:Tretinoin / Q000008:administration & dosage* / Q000009:adverse effects
D014212:Tretinoin; D015474:Isotretinoin; D013752:Tetracycline; D011241:Prednisone