title: Hypersensitivity reactions to amsacrine.
abstract: Five cases of hypersensitivity reactions to amsacrine are reported. These five cases are compared to the three cases previously published. Sixty-two reports on the clinical use of amsacrine in a variety of solid tumors and hematological malignancy were reviewed. Nine cases of hypersensitivity were described in the 2095 patients reported in these clinical trials. The approximate incidence of hypersensitivity to amsacrine is 0.4%.
authors.forename: D J
authors.initials: DJ
authors.lastname: Perry
authors.forename: R B
authors.initials: RB
authors.lastname: Weiss
authors.forename: D F
authors.initials: DF
authors.lastname: Hoth
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000609:Aminoacridines / Q000009:adverse effects*; D000677:Amsacrine; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008545:Melanoma / Q000188:drug therapy; D008875:Middle Aged; D012512:Sarcoma, Ewing / Q000188:drug therapy
chemical_list: D000609:Aminoacridines; D000970:Antineoplastic Agents; D000677:Amsacrine