title: Silicone lymphadenopathy in a long distance runner: complication of a silastic prosthesis.
abstract: A 33-year-old male runner, who had undergone a Swanson silastic prosthetic implant for degenerative joint disease of the first metatarsal head and proximal phalanx of the right great toe, presented with unilateral inguinal lymphadenopathy. Biopsy revealed confluent, non-caseating granulomas containing silastic material. Silicone lymphadenopathy is unusual and most frequently presents as axillary adenopathy in patients with rheumatoid arthritis as a sequelae of prosthetic surgery. This case is clinically distinctive for its site of presentation in a healthy athlete and is histologically remarkable for the marked granulomatous response to the silastic elastomers.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
authors.forename: L A
authors.initials: LA
authors.lastname: Rogers
authors.forename: J A
authors.initials: JA
authors.lastname: Longtine
authors.forename: M B
authors.initials: MB
authors.lastname: Garnick
authors.forename: G S
authors.initials: GS
authors.lastname: Pinkus
mesh_terms: D000328:Adult; D006099:Granuloma / Q000139:chemically induced / Q000473:pathology; D006119:Groin; D006801:Humans; D007595:Joint Prosthesis; D008206:Lymphatic Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D012420:Running; D012826:Silicone Elastomers / Q000009:adverse effects*; D014033:Toe Joint
chemical_list: D012826:Silicone Elastomers