title: [Use of gonadotropin releasing hormone analogs in Marcumar-treated patients for contraception and prevention of life-threatening ovulation hemorrhages].
abstract: Five severe cases of intra-abdominal gynaecological haemorrhage (four haemorrhages from corpora lutea haemorrhagica and one haemorrhage of the endometritis genitalis externa) are described in relation to prolonged marcumar therapy. The problem of contraception in patients under marcumar therapy is highlighted and the possibility is discussed of prevention of ovulation and cardio-vascularly neutral treatment, to achieve contraception as well as avoidance of haemorrhage at ovulation with the Gn-RH analogue Buserelin.
authors.affiliation: Universitäts-Frauenklinik, Freiburg i. Br.
authors.forename: H
authors.initials: H
authors.lastname: Prömpeler
authors.forename: P
authors.initials: P
authors.lastname: Wieacker
authors.forename: H G
authors.initials: HG
authors.lastname: Hillemanns
authors.forename: M
authors.initials: M
authors.lastname: Breckwoldt
mesh_terms: D015110:4-Hydroxycoumarins / Q000009:adverse effects*; D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D002064:Buserelin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008134:Long-Term Care; D010060:Ovulation / Q000187:drug effects*; D010644:Phenprocoumon / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy; D013923:Thromboembolism / Q000517:prevention & control*; D014592:Uterine Hemorrhage / Q000139:chemically induced*
chemical_list: D015110:4-Hydroxycoumarins; D000925:Anticoagulants; D002064:Buserelin; D010644:Phenprocoumon
vernacular_title: Einsatz von Gn-RH-Analoga bei markumarisierten Patientinnen zur Antikonzeption und Prophylaxe von lebensbedrohlichen Ovulationsblutungen.