title: Cholinergic urticaria, passive transfer experiments from human to monkey.
abstract: Passive transfer experiments in cholinergic urticaria were carried out from 16 patients to a Macaca cymnologous monkey. Intravenous Evans blue dye was used to demonstrate vascular permeability. The animal was challenged after 24 h first by heating the serum-injected dorsal skin to 45 degrees C and secondly by superinjection of acetylcholine into serum-injected sites, and a control site. Local heat proved insufficient to evoke a response. Seven of 16 serum-injected sites showed positive reaction to acetylcholine, control injection of acetylcholine did not. These experiments suggest the presence of a serum factor in cholinergic urticaria which, with acetylcholine, causes increased vascular permeability.
authors.affiliation: St John's Hospital for Diseases of the Skin, London, UK.
authors.forename: G M
authors.initials: GM
authors.lastname: Murphy
authors.forename: M W
authors.initials: MW
authors.lastname: Greaves
authors.forename: P E
authors.initials: PE
authors.lastname: Zollman
authors.forename: R K
authors.initials: RK
authors.lastname: Winkelmann
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D000818:Animals; D002799:Cholinergic Fibers / Q000503:physiopathology*; D005260:Female; D000882:Haplorhini; D006801:Humans; D007116:Immunization, Passive; D007271:Injections, Intradermal; D007428:Intradermal Tests; D008297:Male; D008875:Middle Aged; D014581:Urticaria / Q000139:chemically induced*
chemical_list: D000109:Acetylcholine