title: Combined deficiency of coagulation factors II, VII, IX, and X: a case of probable congenital origin.
abstract: Combined deficiency of coagulant activity of the vitamin K-dependent factors was found in a 14-year-old boy suffering from severe hemorrhages. Immunoassays revealed the presence of acarboxyprothrombin. The bleedings could be controlled, but the coagulation defects persisted during more than 2 years' follow-up and could not be corrected by oral or parenteral vitamin K. No intoxication or underlying disease was found. The abnormality was considered a congenital disorder of the carboxylation of prothrombin.
authors.affiliation: Department of Paediatrics, Ostra Sjukhuset, Göteborg, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Ekelund
authors.forename: L
authors.initials: L
authors.lastname: Lindeberg
authors.forename: L
authors.initials: L
authors.lastname: Wranne
mesh_terms: D000293:Adolescent; D001779:Blood Coagulation Factors / Q000096:biosynthesis; D005168:Factor VII Deficiency / Q000150:complications*; D005171:Factor X Deficiency / Q000150:complications*; D005500:Follow-Up Studies; D002836:Hemophilia B / Q000150:complications*; D006474:Hemorrhagic Disorders / Q000209:etiology* / Q000235:genetics; D006801:Humans; D007020:Hypoprothrombinemias / Q000150:complications*; D008297:Male; D011499:Protein Processing, Post-Translational; D011516:Prothrombin / Q000096:biosynthesis; D014812:Vitamin K / Q000502:physiology* / Q000627:therapeutic use
chemical_list: D001779:Blood Coagulation Factors; D014812:Vitamin K; D011516:Prothrombin