title: Rapid removal of DFO-chelated aluminum during hemodialysis using polysulfone dialyzers.
abstract: Aluminum (Al) removal following deferoxamine (DFO) therapy in hemodialysis patients was evaluated in a paired-fashion comparing cuprophane (Travenol 12.11) and polysulfone (Fresenius F-80) dialyzers. QB and QD were held constant at 250 and 500 ml/min, respectively. The polysulfone dialyzer increased total plasma Al clearance from 20.0 +/- 2.8 to 80.5 +/- 7.6 ml/min (P less than 0.01), and reduced the t 1/2 of plasma Al during hemodialysis from 538 +/- 113 to 112 +/- 12 min (P less than 0.01). The polysulfone F-80 dialyzer increased Al removal during the first hour of hemodialysis from 518 +/- 191 to 1812 +/- 720 micrograms/hr (P less than 0.01). During a four hour hemodialysis the F-80 dialyzer returned plasma Al levels to pre-DFO values (103 +/- 36 vs. 93 +/- 23, P less than 0.05), suggesting complete removal of the DFO chelated Al complex. In one patient Al removal was evaluated using cuprophane, F-40, F-60 and F-80 dialyzers and the t 1/2 for Al removed decreased from 484.6 to 276.1 and 108 to 99 minutes, respectively. These data show the Fresenius F-80 polysulfone dialyzer effects the rapid removal of DFO-Al complexes. We propose use of the Fresenius F-80 dialyzer in conjunction with reduced DFO doses and i.m. administration of DFO the day prior to dialysis to limit DFO exposure as a method to decrease DFO-related side-effects in hemodialysis patients.
authors.affiliation: Department of Medicine, Veterans Administration Medical Center, Denver, Colorado.
authors.forename: B A
authors.initials: BA
authors.lastname: Molitoris
authors.forename: A C
authors.initials: AC
authors.lastname: Alfrey
authors.forename: P S
authors.initials: PS
authors.lastname: Alfrey
authors.forename: N L
authors.initials: NL
authors.lastname: Miller
mesh_terms: D000535:Aluminum / Q000009:adverse effects / Q000097:blood*; D003676:Deferoxamine / Q000627:therapeutic use*; D006801:Humans; D008567:Membranes, Artificial; D011108:Polymers; D006435:Renal Dialysis; D013450:Sulfones
chemical_list: D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; D000535:Aluminum; D003676:Deferoxamine