title: Inhibition of HIV replication by amino-sugar derivatives.
abstract: The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and deoxynojirimycin have recently been shown to have potential anti-HIV activity [(1987) Proc. Natl. Acad. Sci. USA 84, 8120-8124; (1987) Nature 330, 74-77; (1987) Lancet i, 1025-1026]. They are thought to act by inhibiting alpha-glucosidase I, an enzyme involved in the processing of N-linked oligosaccharides on glycoproteins. We report here the relative efficacy of a spectrum of amino-sugar derivatives as inhibition of HIV cytopathicity. Several alpha-glucosidase inhibitors and alpha-fucosidase inhibitors were found to be active at concentrations which were non-cytotoxic.
authors.affiliation: Dyson Perrins Laboratory, Department of Organic Chemistry, University of Oxford, England.
authors.forename: G W
authors.initials: GW
authors.lastname: Fleet
authors.forename: A
authors.initials: A
authors.lastname: Karpas
authors.forename: R A
authors.initials: RA
authors.lastname: Dwek
authors.forename: L E
authors.initials: LE
authors.lastname: Fellows
authors.forename: A S
authors.initials: AS
authors.lastname: Tyms
authors.forename: S
authors.initials: S
authors.lastname: Petursson
authors.forename: S K
authors.initials: SK
authors.lastname: Namgoong
authors.forename: N G
authors.initials: NG
authors.lastname: Ramsden
authors.forename: P W
authors.initials: PW
authors.lastname: Smith
authors.forename: J C
authors.initials: JC
authors.lastname: Son
mesh_terms: D000606:Amino Sugars / Q000494:pharmacology*; D002460:Cell Line; D004261:DNA Replication / Q000187:drug effects; D006678:HIV / Q000187:drug effects*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics; D015498:HIV-2 / Q000187:drug effects / Q000235:genetics; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000606:Amino Sugars