Murine candidiasis: strain dependence of host responses after immunization.
After recovery from acute infection with live Candida albicans, both CBA/H and BALB/c mice show increased resistance to colonization by the organism. However, the 'susceptible' CBA/H mice develop much stronger protective responses than do 'resistant' BALB/c mice. This is manifested particularly as a substantial amelioration of the severity of the lesions in the brain, and a very marked reduction in the number of fungal units therein. Analysis of granulocyte function in normal and immune mice of the two strains tended to exclude this as a basis for the different patterns of susceptibility and resistance.
Ashman
R B
RB
Clinical Immunology Research Unit, Princess Margaret Hospital for Children, Subiaco, WA.
Papadimitriou
J M
JM
D000818:Animals; D001921:Brain / Q000473:pathology; D002177:Candidiasis / Q000276:immunology* / Q000473:pathology; D006098:Granulocytes / Q000276:immunology; D007114:Immunization; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity