title: Cutaneous reactions to nonsteroidal anti-inflammatory drugs. A review.
abstract: The nonsteroidal anti-inflammatory drugs are one of the most commonly prescribed classes of drugs used in medical practice. This review discusses the diverse cutaneous reactions associated with nonsteroidal anti-inflammatory drugs. Adverse cutaneous reactions occur most frequently with benoxaprofen, piroxicam, sulindac, meclofenamate sodium, zomepirac sodium, and phenylbutazone. The most serious adverse cutaneous reactions, Stevens-Johnson syndrome and toxic epidermal necrolysis, appear to be most often associated with sulindac and phenylbutazone. Tolmetin and zomepirac sodium, two structurally similar pyrrole derivatives, have been associated with a disproportionate number of cases of anaphylactoid reactions. Among the currently marketed nonsteroidal anti-inflammatory drugs, piroxicam appears to have the highest rate of phototoxic reactions. This phototoxic eruption is most often vesiculobullous.
authors.forename: M
authors.initials: M
authors.lastname: Bigby
authors.forename: R
authors.initials: R
authors.lastname: Stern
mesh_terms: D000085:Acetates / Q000009:adverse effects; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects; D007213:Indomethacin / Q000009:adverse effects; D010894:Piroxicam; D011422:Propionates / Q000009:adverse effects; D011537:Pruritus / Q000139:chemically induced; D011720:Pyrazoles / Q000009:adverse effects; D047069:Pyrazolones; D012459:Salicylates / Q000009:adverse effects; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced*; D013262:Stevens-Johnson Syndrome / Q000209:etiology; D013843:Thiazines / Q000009:adverse effects; D062367:ortho-Aminobenzoates / Q000009:adverse effects
chemical_list: D000085:Acetates; D000893:Anti-Inflammatory Agents; D011422:Propionates; D011720:Pyrazoles; D047069:Pyrazolones; D012459:Salicylates; D013843:Thiazines; D062367:ortho-Aminobenzoates; D010894:Piroxicam; C038362:pyrazolone; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin