Biosynthesis of anthracyclinones.
Recent biosynthetic studies confirmed that anthraquinones are involved as intermediates in the pathway to anthracyclines. The present knowledge in this field has been reviewed. Furthermore, a new generalized order of biosynthetic intermediates from the hypothetical polyketide to aklavinone and related anthracyclinones has been proposed involving tricyclic precursors and 7-hydroxy-naphthacenequinones, which also have been found in mutants of anthracycline-producing strains.
Eckardt
K
K
Akademie der Wissenschaften der DDR, Zentralinstitut für Mikrobiologie und experimentelle Therapie, Jena.
Wagner
C
C
D000880:Anthraquinones / Q000378:metabolism; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D009279:Naphthacenes / Q000096:biosynthesis / Q000378:metabolism; D013302:Streptomyces / Q000378:metabolism
D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; C027832:aklavinone