[Acute primary phase as an indicator of HIV-1 infection. The general symptoms and polymorphic exanthema with mouth mucosal involvement 2 to 6 weeks before seroconversion].
The initial symptoms of an HIV-1 infection were observed in four patients. The following were characteristic for the acute primary phase: (a) initial maculopapular exanthema, especially of the trunk, with occasional transition into a papulovesical appearance; (b) involvement of the oral mucosa, often of aphthous character; and (c) general malaise with fever and lymphadenopathy. The observed cutaneous changes had, on one hand, features of a Coxsackie or mononucleosis exanthema, on the other of secondary syphilis. In three patients seroconversion occurred within 2-6 weeks, the fourth failed to return for follow-up. The listed acute primary symptoms can be used as the earliest indicators of an HIV-1 infection having occurred.
Bratzke
B
B
Universitäts-Hautklinik und Poliklinik, Klinikum Steglitz, Freie Universität Berlin.
Eichhorn
R
R
Höffken
G
G
Bratzke
C
C
Stadler
R
R
Ehlers
G
G
Orfanos
C E
CE
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000473:pathology; D000208:Acute Disease; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D005076:Exanthema / Q000175:diagnosis* / Q000473:pathology; D015483:HIV Antibodies; D006679:HIV Seropositivity / Q000175:diagnosis*; D006716:Homosexuality; D006801:Humans; D008297:Male; D009059:Mouth Diseases / Q000175:diagnosis* / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology; D013997:Time Factors
D000914:Antibodies, Viral; D015483:HIV Antibodies
Akute Primärphase als Indikator der HIV-1-Infektion. Allgemeine Symptomatik und polymorphes Exanthem mit Mundschleimhautbeteiligung 2-6 Wochen vor der Serokonversion.