[Chromosomal instability related to disordered replication and repair processes of DNA synthesis in the cells of patients with gouty nephropathy].
Lymphocytes of patients with gouty nephropathy were investigated using the criteria of sister chromatid exchanges (SCE) formation, rapidity of generation, virus reactivation, detection of the level of virus mutagenesis and DNA repair and replication synthesis in the experiments with some mutagens. Disorders, according to these criteria, were observed in the cells of all the patients. Cells of patients with gouty nephropathy may be used as a model to study DNA repair and replication mechanisms.
Zasukhina
G D
GD
Sura
V V
VV
Alekhina
N I
NI
Chekova
V V
VV
L'vova
G N
GN
D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D004261:DNA Replication / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D006073:Gout / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics* / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology / Q000528:radiation effects; D009153:Mutagens / Q000494:pharmacology; D009154:Mutation; D012854:Sister Chromatid Exchange / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays; D014616:Vaccinia virus / Q000187:drug effects / Q000254:growth & development / Q000528:radiation effects; D014775:Virus Activation / Q000187:drug effects / Q000528:radiation effects
D009153:Mutagens; D004247:DNA
Khromosomnaia nestabil'nost', sviazannaia s narusheniem protsessov replikatsii i reparatsii sinteza DNK, v kletkakh bol'nykh podagricheskoĭ nefropatieĭ.