Inhibition of mouse liver alcohol dehydrogenase by methyl N-butyl ketone.
Methyl N-butyl ketone (MNBK) inhibited the activity of mouse liver alcohol dehydrogenase (LADH) in vitro. Ethanol elimination was reduced in MNBK-treated mice as compared to controls. Ethanol-induced induced loss of righting reflex was significantly prolonged in mice pretreated with MNBK.
Sharkawi
M
M
Elfassy
B
B
D000426:Alcohol Dehydrogenase; D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002849:Chromatography, Gas; D000431:Ethanol / Q000097:blood / Q000378:metabolism; D066298:In Vitro Techniques; D007659:Ketones / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008742:Methyl n-Butyl Ketone / Q000494:pharmacology*; D051379:Mice; D013997:Time Factors
D007659:Ketones; D000431:Ethanol; D008742:Methyl n-Butyl Ketone; D000429:Alcohol Oxidoreductases; D000426:Alcohol Dehydrogenase