title: A multicenter study of the in vitro antianaerobic activity of cefotetan compared with other antimicrobial agents.
abstract: The in vitro antianaerobic activity of cefotetan was compared with that of chloramphenicol, clindamycin, cefoxitin, and penicillin in a multicenter study. Both agar dilution and broth microdilution testing procedures, as described by the National Committee for Clinical Laboratory Standards (NCCLS), were employed; a total of 1,377 strains were examined. Results were interpreted using the U.S. Food and Drug Administration- and NCCLS-recommended criteria. This study indicates that Bacteroides fragilis, Clostridium difficile, and most other clinically significant anaerobic bacteria are susceptible to cefotetan.
authors.affiliation: Department of Pathology and Laboratory Medicine, Sinai Samaritan Medical Center, Milwaukee, Wisconsin 53201-0342.
authors.forename: R J
authors.initials: RJ
authors.lastname: Zabransky
authors.forename: D G
authors.initials: DG
authors.lastname: Bobey
authors.forename: W
authors.initials: W
authors.lastname: Sheikh
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001439:Bacteroides / Q000187:drug effects; D015313:Cefotetan; D002440:Cefoxitin / Q000494:pharmacology; D002513:Cephamycins / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D003013:Clostridium / Q000187:drug effects; D007755:Laboratories, Hospital; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002513:Cephamycins; D010406:Penicillins; D002981:Clindamycin; D015313:Cefotetan; D002701:Chloramphenicol; D002440:Cefoxitin