[Excitatory effect of subthalamo-nigral and subthalamo-pallidal efferent pathways in the rat].
Microinjections of the GABA antagonist, bicuculline, where shown to selectively activate subthalamic neurons in the rat. Stimulation of subthalamic efferent pathways increased the neuronal discharge in the pallidal complex and pars reticulata of the substantia nigra. Most nigral dopaminergic neurons displayed a slight decrease in firing rate. According to these results, which are more coherent than those obtained through electrical stimulation, the subthalamic nucleus may be considered a source of tonic activation of the two output structures of the basal ganglia viz, pars reticulata of the substantia nigra and entopeduncular nucleus.
Robledo
P
P
Laboratoire de Pharmacologie, Faculté des Sciences pharmaceutiques et biologiques, Université René-Descartes, Paris.
Vezole
I
I
Feger
J
J
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D004525:Efferent Pathways / Q000187:drug effects; D005917:Globus Pallidus / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013378:Substantia Nigra / Q000187:drug effects*; D013787:Thalamic Nuclei / Q000187:drug effects* / Q000502:physiology
D001640:Bicuculline
Mise en évidence d'un effet excitateur des efférences subthalamo-nigrales et subthalamo-pallidales chez le rat.