Intraocular penetration of cytosine arabinoside following intravenous administration in primates.
Cytosine arabinoside was administered intravenously to three monkeys. Blood, aqueous, and vitreous specimens were collected after 30 minutes, 1 hour, 2 hours, and 3 hours. Intraocular and intravenous drug concentrations were comparable at all time points, at levels likely to be effective against human tumors. This study suggests that therapeutic intraocular concentrations of cytosine arabinoside are attained following intravenous administration in primates.
Smiddy
W E
WE
Ocular Oncology Service, Wilmer Ophthalmological Institute, Baltimore, Maryland.
Graham
M L
ML
Cheo
D L
DL
Schachat
A P
AP
D000818:Animals; D003561:Cytarabine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005123:Eye / Q000187:drug effects* / Q000378:metabolism; D007275:Injections, Intravenous; D008252:Macaca fascicularis
D003561:Cytarabine