Disposition of ifosfamide in patients receiving ifosfamide infusion therapy for the treatment of cervical carcinoma.
The disposition of ifosfamide was investigated in nine patients receiving a total of 23 72-h infusions. There was no linear relationship between steady-state plasma concentrations and either vomiting or CNS toxicity. The steady-state plasma concentrations were reproducible within patients, but there was a wide variation between patients. The progress of the disease did not affect the disposition of ifosfamide.
Pearcey
R
R
University Department of Radiotherapy, Cookridge Hospital, Leeds, UK.
Calvert
R
R
Mehta
A
A
D005260:Female; D006207:Half-Life; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*; D014839:Vomiting / Q000139:chemically induced
D007069:Ifosfamide