Comparison of the thrombogenicity of four types of knitted Dacron arterial graft in an artificial circulation.
The thrombogenicity of four types of knitted Dacron arterial graft was compared by measuring the effect of each prosthetic graft on human platelet function in an artificial circulation. The grafts examined were plain knitted (Meadox 'Cooley'), knitted double velour (Meadox 'Microvel'), filamentous external velour (U.S.C.I. 'Sauvage Filamentous') and a plain knitted graft with a pyrolytic carbon coating (Meadox 'Carboknit'). Platelet count, adhesion and percentage aggregation were all decreased during perfusion. The greatest changes in these parameters were produced by the filamentous velour graft and the least by the carbon coated graft. Electron microscopy demonstrated significantly more platelets adherent to the filamentous graft (rho less than 0.01) with changes in platelet morphology indicating activation. These results suggest that the filamentous graft is more thrombogenic than the other grafts.
Deacon
P
P
Crow
M J
MJ
Rajah
S M
SM
Kester
R C
RC
D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D006801:Humans; D066298:In Vitro Techniques; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D010976:Platelet Count; D011093:Polyethylene Terephthalates / Q000009:adverse effects*; D013927:Thrombosis / Q000209:etiology*
D011093:Polyethylene Terephthalates