Three Japanese families with members carrying C7 silent allele (C7*Q0). Possibility for an association between C7*Q0 and C6*B.
Three Japanese families with members carrying C7 silent allele(s) (C7*Q0) are presented. C6 types in the family members were also examined, and it was found that C7*Q0 was transmitted from a parent to offsprings as a haplotype, C7*Q0-C6*B. In another study of C6 types in sera from 3 volunteer blood donors with homozygous C7 deficiencies, the C6 phenotypes were found to be C6 B (homozygote). It seems remarkable that C7*Q0 can be associated with C6*B.
Nishimukai
H
H
Department of Legal Medicine, School of Medicine, Ehime University, Japan.
Kitamura
H
H
Takeuchi
Y
Y
Shinomiya
T
T
Tamaki
Y
Y
D000483:Alleles; D003183:Complement C6 / Q000172:deficiency / Q000235:genetics*; D003184:Complement C7 / Q000172:deficiency / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006239:Haplotypes; D006801:Humans; D007564:Japan; D008297:Male; D010375:Pedigree; D010641:Phenotype
D003183:Complement C6; D003184:Complement C7