Bone marrow response to single small doses of irradiation: implications for stem cell functional organization.
The data collected in 107 experiments over 23 months have been pooled to indicate the responses of cellularity, stem cell (CFU-S) number, and CFU-S proliferation rate (CFU-S in S-phase) during early recovery of the bone marrow from 1.5 and 2.6 Gy irradiation. The bone marrow differentials and numbers of granulocyte-macrophage progenitors (CFC-GM) were determined after irradiation with 1.5 Gy. The CFU-S proliferation rate was examined also in mice irradiated with 3.5-5.0 Gy. The data are discussed in the light of various hypotheses about the functional organization of the CFU-S population. It is proposed that the control of the CFU-S production rate is primary rather than the control of CFU-S numbers.
Necas
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Department of Pathophysiology, Faculty of General Medicine, Charles University, Prague, Czechoslovakia.
Znojil
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V
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D001854:Bone Marrow Cells; D002452:Cell Count; D002453:Cell Cycle; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006098:Granulocytes / Q000166:cytology*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D008264:Macrophages / Q000166:cytology*; D008297:Male; D051379:Mice; D013997:Time Factors