Displacement of cell-surface associated calcium inhibits phagocytosis and Ca-ATPase activity in amoeba.
Displacement of calcium from the cell surface region was observed in cells treated with either chlorpromazine or reserpine with chlorotetracycline being used as a calcium-fluorescent probe. The drugs also significantly inhibit the intensity of phagocytosis and Ca-ATPase activity. The possible role of Ca associated with the cell surface region in regulation of both phagocytosis and Ca-ATPase was discussed.
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D000656:Amoeba / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000502:physiology*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002746:Chlorpromazine / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology
D012110:Reserpine; D000252:Calcium-Transporting ATPases; D002118:Calcium; D002746:Chlorpromazine