Simultaneous expression of lymphoid and myeloid phenotypes in acute leukemia arising from myelodysplastic syndrome.
A 57-year-old female developed myelodysplastic syndrome (MDS) that terminated as a biphenotypic leukemia after exposure to chemoradiotherapy. Double staining of blast cells, using monoclonal antibodies specific for myeloid and lymphoid lineage, demonstrated that one-third of the leukemic cells simultaneously expressed the E rosette-associated antigen (OKT11) and myeloid-associated antigen (MY7). This finding suggests the possibility that some cases of MDS are clonal disorders that arise in a pluripotent stem cell that can also differentiate to T cell lineage.
Komatsu
N
N
Department of Medicine, Jichi Medical School, Tochigi-ken, Japan.
Yoshida
M
M
Eguchi
M
M
Akashi
M
M
Sasaki
R
R
Sakamoto
S
S
Miura
Y
Y
D000208:Acute Disease; D001853:Bone Marrow / Q000473:pathology; D003131:Combined Modality Therapy / Q000009:adverse effects; D005260:Female; D006402:Hematologic Diseases / Q000209:etiology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D007951:Leukemia, Myeloid / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000628:therapy; D010641:Phenotype; D010976:Platelet Count