title: Promoting effect of nicotinamide on the development of renal tubular cell tumors in rats initiated with diethylnitrosamine.
abstract: Nicotinamide administered in the drinking water of male Fischer 344 rats increased the number of renal tubular cell tumors of rats treated with an i.p. injection of diethylnitrosamine (DEN) (25-mg/kg body weight). The incidence of kidneys with tumors in rats treated with DEN alone was 5%. In rats which received DEN and then were promoted with either 30 or 6.7 mM nicotinamide in their drinking water, the incidence of kidneys with tumors rose to 59 and 28%, respectively. Rats which were on 30 mM nicotinamide but did not receive DEN had no kidney tumors present. These results show that nicotinamide promoted DEN-induced renal tubular cell tumorigenesis.
authors.forename: M R
authors.initials: MR
authors.lastname: Rosenberg
authors.forename: D L
authors.initials: DL
authors.lastname: Novicki
authors.forename: R L
authors.initials: RL
authors.lastname: Jirtle
authors.forename: A
authors.initials: A
authors.lastname: Novotny
authors.forename: G
authors.initials: G
authors.lastname: Michalopoulos
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003043:Cocarcinogenesis; D004052:Diethylnitrosamine; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology; D007684:Kidney Tubules / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D009536:Niacinamide / Q000494:pharmacology*; D009602:Nitrosamines; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D009602:Nitrosamines; D009536:Niacinamide; D004052:Diethylnitrosamine