Theophylline reverses haloperidol-induced catalepsy in the rat. Possible relevance to the pharmacological treatment of psychosis.
The effect of theophylline (5, 15, or 30 mg/kg sc) on the catalepsy induced by haloperidol in the rat was studied. Theophylline was shown to induce a dose-dependent inhibition of this catalepsy. These data support the hypothesis that the methylxanthines are dopamine agonists and suggest that coffee, tea, and cola drinks should be avoided by patients undergoing neuroleptic treatment.
Casas
M
M
Laboratori de Neuropsicofarmacologia, Fundació d'Investigació de la Santa Creu i Sant Pau, Hospital de S. Pau, (Medical School, U.A.B.), Barcelona, Spain.
Ferre
S
S
Guix
T
T
Jane
F
F
D000818:Animals; D001921:Brain / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D013806:Theophylline / Q000494:pharmacology*
D011954:Receptors, Dopamine; D013806:Theophylline; D006220:Haloperidol