title: Ontogenesis and regulation of steroid sulfatase activity in Leydig cells and seminiferous tubules in the Long-Evans rat.
abstract: Steroid sulfatase (STS) activity was studied in Long-Evans rat testis. The affinity of the enzyme was shown to increase during postnatal development and to be always higher in purified Leydig cells than in seminiferous tubules. STS activity appeared to be higher in the seminiferous tubules at the earlier stages. In vivo injection of 100 IU hCG resulted in a decrease in the affinity and an increase in the activity of the enzyme expressed in Leydig cells with no such modification in seminiferous tubules. This suggests that STS could play a regulatory role in testosterone production by Leydig cells.
authors.affiliation: INSERM U. 166, Groupe de Recherches sur l'Endocrinologie de la Reproduction, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Bedin
authors.forename: T
authors.initials: T
authors.lastname: Fournier
authors.forename: N
authors.initials: N
authors.lastname: Mouhadjer
authors.forename: G
authors.initials: G
authors.lastname: Pointis
mesh_terms: D000375:Aging; D000818:Animals; D007700:Kinetics; D007985:Leydig Cells / Q000201:enzymology*; D008297:Male; D051381:Rats; D012671:Seminiferous Tubules / Q000201:enzymology / Q000254:growth & development*; D043266:Steryl-Sulfatase; D013429:Sulfatases / Q000378:metabolism*; D013737:Testis / Q000254:growth & development*
chemical_list: D013429:Sulfatases; D043266:Steryl-Sulfatase