title: Screening of the influence of flavonoids on lipoxygenase and cyclooxygenase activity, as well as on nonenzymic lipid oxidation.
abstract: Thirty nine flavonoids, isolated from plants, were tested in respect of their influence on soybean lipoxygenase activity, cyclooxygenase activity and inhibition of ascorbic acid-stimulated malonaldehyde formation in liver lipids. Almost all of the tested compounds were antioxidants and stimulated cyclooxygenase when arachidonic acid was used as a substrate at a concentration of 100 microM. Eleven flavonoids were inhibitors of soybean lipoxygenase. A good correlation between the chemical structure and the tested activity was observed. The most active compounds in all tests were luteolin, 6-hydroxyluteolin, nepetin, quercetagetin, patuletin and myricetin.
authors.affiliation: Department of Pharmacology, Copernicus Academy of Medicine, Kraków, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Robak
authors.forename: F
authors.initials: F
authors.lastname: Shridi
authors.forename: M
authors.initials: M
authors.lastname: Wolbís
authors.forename: M
authors.initials: M
authors.lastname: Królikowska
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001091:Arachidonate Lipoxygenases / Q000037:antagonists & inhibitors*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D016861:Cyclooxygenase Inhibitors; D005419:Flavonoids / Q000494:pharmacology*; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D016859:Lipoxygenase Inhibitors; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats
chemical_list: D000975:Antioxidants; D016861:Cyclooxygenase Inhibitors; D005419:Flavonoids; D016859:Lipoxygenase Inhibitors; D001091:Arachidonate Lipoxygenases