title: Family data support a dominant major gene for Tourette syndrome.
abstract: A dominant major gene was supported by analyses of 50 large extended Tourette syndrome (TS) pedigrees and by a subset of families defined by proband's clinical response to the neuroleptic drug haloperidol. Relatives were defined as affected if they ever had tics or TS. Assuming a nearly even sex ratio for TS and related symptoms resulted in the best fit of the genetic model to observed rates in families.
authors.affiliation: Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: R A
authors.initials: RA
authors.lastname: Price
authors.forename: D L
authors.initials: DL
authors.lastname: Pauls
authors.forename: S D
authors.initials: SD
authors.lastname: Kruger
authors.forename: E D
authors.initials: ED
authors.lastname: Caine
mesh_terms: D002874:Chromosome Mapping; D005799:Genes, Dominant; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D010375:Pedigree; D005879:Tourette Syndrome / Q000188:drug therapy / Q000235:genetics*
chemical_list: D006220:Haloperidol