Long-term effect on the immune status of defined diets during the early postnatal period in the rat.
Germ-free and conventional infant rats delivered by hysterectomy were reared artificially, using one of two diets--diet LNa (with a high saturated fatty acid content) and diet K 50 (with a high unsaturated fatty acid content). Animals reared for a short time (up to 5 days) after birth on the LNa diet had a low antibody (PFC = plaque-forming lymphocyte) response and low resistance to Yoshida's sarcoma. Rats reared on the K 50 diet had the same response as the suckled controls. The first 5 days after birth were found to be the decisive period for long-term consequences of nutrition.
Stĕpánková
R
R
Sterzl
J
J
Trebichavský
I
I
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000917:Antibody Formation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D012509:Sarcoma / Q000276:immunology / Q000473:pathology; D013997:Time Factors
D004041:Dietary Fats; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated