Influence of radiographic contrast media on phagocytosis.
To evaluate the influence of radiographic contrast media (CM) on human polymorphonuclear leucocytes (PML), the ability of these cells to ingest latex particles after in vitro exposure to five different radiographic contrast media was investigated. All CM inhibited the phagocytic properties of PML. The inhibition was dose dependent. The inhibitory effect was partly due to hyperosmolality but CM specific inhibition was also evident.
Rasmussen
F
F
Department of Diagnostic Radiology, Odense University Hospital, Denmark.
Georgsen
J
J
Grunnet
N
N
D003287:Contrast Media / Q000494:pharmacology*; D003973:Diatrizoate / Q000494:pharmacology; D006098:Granulocytes / Q000502:physiology*; D006801:Humans; D007472:Iohexol / Q000494:pharmacology; D007479:Iopamidol / Q000494:pharmacology; D007485:Ioxaglic Acid / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects*; D014283:Triiodobenzoic Acids / Q000494:pharmacology
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D007472:Iohexol; C044834:iodixanol; D007479:Iopamidol; D007485:Ioxaglic Acid