title: Immunogenicity of a five-microgram dose of hepatitis B vaccine.
abstract: The immunogenicity of a 5-micrograms dose of vaccine (H-B-Vax, MSD) was evaluated in 50 young adults (17-19 years). Results were compared to our previous studies using similarly prepared vaccines using 20 micrograms and 10 micrograms per dose with the same trial protocol in a comparable population. Seroconversion rates for the 5-micrograms doses of vaccine were 80% after the first dose and 98% after the second dose. The remaining participants did not develop anti-HBs in the course of the trial. These results are not significantly different from those observed in the 10-micrograms and 20-micrograms studies. The increase of anti-HBs titers was slower for the 5-micrograms group. High geometric mean titers were observed after booster vaccination, but lower for the 5 micrograms (3,591 mIU/ml) than for 10 micrograms (9,277 mIU/ml) and 20 micrograms (12,975 mIU/ml) doses. It is concluded that 5-micrograms dose of the vaccine is effectively immunogenic for young adults.
authors.forename: G
authors.initials: G
authors.lastname: Papaevangelou
authors.forename: A
authors.initials: A
authors.lastname: Roumeliotou-Karayannis
authors.forename: C
authors.initials: C
authors.lastname: Vissoulis
authors.forename: S C
authors.initials: SC
authors.lastname: Richardson
authors.forename: S
authors.initials: S
authors.lastname: Krugman
mesh_terms: D000293:Adolescent; D000328:Adult; D006510:Hepatitis B Antibodies / Q000096:biosynthesis*; D017325:Hepatitis B Vaccines; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D013997:Time Factors; D014611:Vaccination; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D014761:Viral Hepatitis Vaccines