The cardiovascular effects of nebulized adenosine in man.
We have studied the cardiovascular effects of inhaled adenosine in healthy subjects. Adenosine at a concentration of 5 mg.ml-1 is absorbed and produces an increase in heart rate of 6-7 beats per min, blood pressure and skin temperature being unaltered. The rise in heart rate is less than that seen with an infusion of a comparable dose and is unlikely to be adequate for therapeutic termination of supraventricular tachycardia. Higher doses are limited by the poor solubility of adenosine. Inhalation as a method of delivering adenosine has possibilities as an alternative route of administration, but some practical problems remain to be overcome.
Coupe
M O
MO
Department of Cardiology, Brompton Hospital, London, UK.
Clarke
B
B
Robson
A
A
Oldershaw
P J
PJ
Barnes
P J
PJ
D000241:Adenosine / Q000008:administration & dosage / Q000494:pharmacology*; D000280:Administration, Inhalation; D001794:Blood Pressure / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D009330:Nebulizers and Vaporizers; D012881:Skin Temperature / Q000187:drug effects*
D000241:Adenosine