Smoking, gastric secretion and inhibition by cimetidine.
The pharmacologic response to cimetidine was studied in 8 patients with duodenal ulcers in remission whilst smoking and during abstinence. No significant difference was found in overnight intra-gastric acidity, acid or pepsin output. These data do not support the hypothesis that pharmacologic response to H2 receptor antagonists is impaired in smokers.
Deakin
M
M
Department of Gastroenterology, Royal Naval Hospital, Haslar, Gosport, England.
Ramage
J K
JK
Williams
J G
JG
D000328:Adult; D002927:Cimetidine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000009:adverse effects*
D002927:Cimetidine