[Characterization of the leukemic cell population in a patient with T-ALL at disease beginning and in recurrence: parallel changes in phenotypic and functional behavior].
The phenotypic and functional characteristics of the leukemic cells from one patient with a suppressor T-ALL were studied. At the time of diagnosis a high proportion of OKT8 positive (suppressor/cytotoxic) cells were identified which mediated strong suppressor activity to the differentiation of allogenic B-cells. A complete remission of 12 months duration was achieved by chemotherapy. In the relapse the marker analysis showed a dramatic decrease of the OKT8 positive cell fraction. Functionally the suppressor activity was completely lost indicating a close correlation between phenotype and functional activity also in a leukemic cell population.
Sieber
G
G
Ludwig
W D
WD
Rühl
H
H
D000328:Adult; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology*; D007958:Leukocyte Count; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal
Charakterisierung der leukämischen Zellpopulation bei einem Patienten mit T-ALL im Krankheitsbeginn und im Rezidiv: Parallele Veränderungen im phänotypischen und funktionellen Verhalten.