Presence of lorazepam in the blood plasma of drug free rats.
Lorazepam has been identified in the blood plasma of non-medicated rats by means of HPLC and gas chromatography combined with mass spectrometry. It was found to be present in about 1 ng per ml blood plasma. This pharmacologically highly active compound is the first dichlorinated benzodiazepine described to occur naturally in a tissue of mammals, not treated with benzodiazepines.
Wildman
J
J
Pharmaceutical Research Department, F. Hoffman-La Roche & Co., Ltd., Basle, Switzerland.
Ranalder
U
U
D000818:Animals; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D008140:Lorazepam / Q000097:blood*; D013058:Mass Spectrometry; D051381:Rats
D008140:Lorazepam