The penetration of fleroxacin into intra-abdominal abscesses.
Using a recently developed, low mortality model of an intra-abdominal abscess in the Wistar rat, we have studied the penetration of fleroxacin into the abscess. Maximum serum concentration was 1.83 +/- 0.39 mg l and occurred 1 h after iv injection (20 mg/kg), but even at 4 h after administration the mean serum level was 1.21 +/- 0.27 mg/l. By contrast, levels in pus were 6.27 +/- 0.83 mg/l at 1 h rising steadily to a value of 12.7 +/- 3.69 mg/l at 4 h. The study has confirmed exceptional antibiotic penetration into the abscess, with levels at all time intervals between 0.5 and 8 h after administration in excess of the MIC50 for Escherichia coli, Proteus vulgaris and Clostridium perfringens.
Youngs
D J
DJ
Department of Microbiology, General Hospital, Birmingham, UK.
Tudor
R G
RG
Yoshioka
K
K
Keighley
M R
MR
D000005:Abdomen; D000038:Abscess / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D016576:Fleroxacin; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D016576:Fleroxacin