Individual specific DNA fingerprints from a hypervariable region probe: alpha-globin 3'HVR.
A probe detecting a hypervariable region (HVR) 3' to the alpha globin locus on chromosome 16 has been used to produce DNA fingerprints. Segregation analysis has revealed multiple, randomly dispersed DNA fragments inherited in a Mendelian fashion with minimal allelism and linkage. The fingerprints are highly polymorphic (probability of chance association between random individuals much less than 10(-14]. The probe is, therefore, a powerful discriminating tool: it is envisaged that this probe will have forensic applications, including paternity cases, and will be informative in linkage analysis.
Fowler
S J
SJ
Central Research Establishment, Home Office Forensic Science Service, Aldermaston, Reading, Berks, UK.
Gill
P
P
Werrett
D J
DJ
Higgs
D R
DR
D000483:Alleles; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005914:Globins / Q000235:genetics*; D006801:Humans; D008297:Male; D009710:Nucleotide Mapping
D005819:Genetic Markers; D005914:Globins; D004247:DNA