title: In vivo imaging and evaluation of platelet accumulation vs. time at arterial injury site.
abstract: The feasibility of quantitatively imaging platelet deposition over time following angioplasty of the abdominal aorta in a rabbit model, with and without antiplatelet treatment, was investigated. Ten male 3-4 kg rabbits were balloon de-endothelialized and placed on 2% cholesterol diet for eight weeks. Group A was untreated. In Group B, donors and recipients were treated with aspirin (5 mgm/kg) prior to and after angioplasty. Platelets were labelled with indium-111. Labelled platelets were injected just prior to PTA and images of 100,000 counts were obtained immediately and at 30 minutes, 1 hour, and 24 hours. In Group A, increased activity of angioplasty site vs. nonangioplastied aorta was seen immediately. This focal increase became more marked in hypercholesterolemic animals over the 24-hour period. In Group B, both hypercholesterolemic and normocholesterolemic, no focal uptake could be documented on sequential scans. This method and model are promising for in vivo evaluation of platelet-vessel wall interactions, in the setting of angioplasty and antiplatelet therapy.
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: M A
authors.initials: MA
authors.lastname: Bettmann
authors.forename: B
authors.initials: B
authors.lastname: Adelman
authors.forename: D C
authors.initials: DC
authors.lastname: Levin
authors.forename: R
authors.initials: R
authors.lastname: Miller
authors.forename: J
authors.initials: J
authors.lastname: Finkelstein
authors.forename: M
authors.initials: M
authors.lastname: Hunt
mesh_terms: D000800:Angioplasty, Balloon; D000818:Animals; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging* / Q000293:injuries; D001161:Arteriosclerosis / Q000000981:diagnostic imaging; D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000502:physiology; D006937:Hypercholesterolemia / Q000000981:diagnostic imaging; D007204:Indium; D008297:Male; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D011292:Premedication; D011817:Rabbits; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013997:Time Factors; D014945:Wound Healing
chemical_list: D011868:Radioisotopes; D007204:Indium; D001241:Aspirin