title: Ontogeny of mitogen responsive lymphocytes in the bovine fetus.
abstract: Bovine fetal lymphocytes were examined for their ability to respond to the mitogens phytohemagglutinin (PHA), Concanavalin A (ConA) and pokeweed mitogen (PWM) in the lymphocyte blastogenesis test (LBT). PHA-, Con A- and PWM-responsive lymphocytes appeared simultaneously at 75-80 days of gestation. The response increased with age of the fetus until, by 120 days of gestation, the response to PHA, Con A and PWM of many fetuses was in the range of values obtained with lymphocytes from normal adult cattle.
authors.affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
authors.forename: J
authors.initials: J
authors.lastname: Jensen
authors.forename: M
authors.initials: M
authors.lastname: Rubino
authors.forename: W C
authors.initials: WC
authors.lastname: Yang
authors.forename: A J
authors.initials: AJ
authors.lastname: Cooley
authors.forename: R D
authors.initials: RD
authors.lastname: Schultz
mesh_terms: D000818:Animals; D002417:Cattle / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology; D005333:Fetus / Q000276:immunology*; D005865:Gestational Age; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology
chemical_list: D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D003208:Concanavalin A