Contact allergy to aziridine paint hardener.
A painter experienced an extensive dermatitis when exposed to a paint primer (undercoating) used to protect wood siding. The primer was an acrylic emulsion with a polyfunctional aziridine added as a self-curing cross-linker or hardener. The polyfunctional aziridine cross-linker was made by reacting propyleneimine with a polyfunctional acrylate, trimethylolpropane triacrylate (TMPTA). Our patient reacted to the cross-linker and also reacted to TMPTA, which is present in excess in the cross-linker. He also cross-reacted to pentaerythritol triacrylate (PETA). Both TMPTA and PETA can be used in the production of aziridine hardeners and both are well known as sensitizers in radiation-dried acrylic printing inks and coatings.
Cofield
B G
BG
Storrs
F J
FJ
Strawn
C B
CB
D000179:Acrylates / Q000009:adverse effects; D001388:Aziridines / Q000009:adverse effects*; D001389:Azirines / Q000009:adverse effects*; D055598:Chemical Phenomena; D002621:Chemistry; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010150:Paint / Q000009:adverse effects*; D010328:Patch Tests; D011409:Propylene Glycols
D000179:Acrylates; D001388:Aziridines; D001389:Azirines; D011409:Propylene Glycols; C027993:trimethylolpropane triacrylate; C033132:aziridine; C027992:pentaerythrityl triacrylate