Treatment with an LHRH agonist or hCG increases interstitial fluid volume and permeability to Evans blue in the mouse testis.
Treatment of adult mice with 1 microgram of an LHRH-agonist or with 5 i.u. hCG, subcutaneously, resulted in an increase in the permeability to intravenously injected Evans blue into the testicular interstitial space and in the volume of testicular interstitial fluid. These changes are probably related to an increase in vascular permeability but, in contrast to the situation in rats, this was accompanied neither by an accumulation of polymorphonuclear leucocytes in testicular blood vessels nor by the formation of large inter-endothelial cell gaps in postcapillary venules. The mechanisms mediating the gonadotrophin-induced increase in vascular permeability in the mouse testis thus remain unknown.
Bergh
A
A
Department of Pathology, University of Umeå, Sweden.
Damber
J E
JE
D000818:Animals; D002064:Buserelin / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects*; D006063:Chorionic Gonadotropin / Q000493:pharmacokinetics / Q000494:pharmacology*; D005070:Evans Blue; D005110:Extracellular Space / Q000187:drug effects; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000187:drug effects; D013268:Stimulation, Chemical; D013737:Testis / Q000098:blood supply / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone; D005070:Evans Blue; D002064:Buserelin