Controversy in the management of optic pathway gliomas. 29 patients treated with radiation therapy at Baylor College of Medicine from 1967 through 1987.
The optic gliomas of 29 patients, including 14 with von Recklinghausen neurofibromatosis (NF-1), were subjected to X-ray therapy. The data indicate a projected 20-year survival rate of 92% for all 29 patients. Moreover, among the NF-1 patients, 86% were stabilized or improved, while among non-NF-1 patients, only 47% stabilized or were improved. Thus, these data suggest that there are differences in the biophysiological behavior of optic nerve gliomas in patients with NF-1, and, as well, that there is a salutary response to radiation treatment as measured by improvement or stabilization of vision, with and without radiologic evidence of concomitant tumor regression.
Easley
J D
JD
Department of Radiation Oncology, Baylor College of Medicine, Houston, Tex.
Scharf
L
L
Chou
J L
JL
Riccardi
V M
VM
D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000150:complications / Q000532:radiotherapy*; D002648:Child; D002675:Child, Preschool; D003390:Cranial Nerve Neoplasms / Q000150:complications / Q000532:radiotherapy*; D005260:Female; D005910:Glioma / Q000150:complications / Q000532:radiotherapy*; D006801:Humans; D007223:Infant; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications*; D009901:Optic Nerve Diseases / Q000150:complications / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies