title: Histidine analogues as potential novel antirheumatic agents.
abstract: The relative avidity of novel analogues of histidine for copper chelation, and the ability of such chelates to catalyse the dismutation of the superoxide radical have been assessed using a new in vitro test. The test, designed to detect potential novel antirheumatic agents, was based on a putative mode of action for D-penicillamine. Within the series of histidine analogues, relationships between structure and activity were determined, isohistidine (alpha-amino-2-imidazolepropionic acid) and some of its simple derivatives being particularly active.
authors.affiliation: Roche Products Limited, Welwyn Garden City, Hertfordshire, UK.
authors.forename: N A
authors.initials: NA
authors.lastname: Roberts
authors.forename: B P
authors.initials: BP
authors.lastname: Tong
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002614:Chelating Agents; D003300:Copper / Q000032:analysis; D004492:Edetic Acid / Q000494:pharmacology; D006639:Histidine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D010396:Penicillamine / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002614:Chelating Agents; D006639:Histidine; D003300:Copper; D004492:Edetic Acid; D013482:Superoxide Dismutase; D010396:Penicillamine