Generation of T cell growth factor (TCGF)- dependent splenic lymphoid cell line with cell-mediated immunosuppressive reactivity against syngeneic murine tumor.
Splenic T cells obtained from tumor-bearing mice could be cultured with T cell growth factor (TCGF) for over 12 months. The TCGF-dependent lymphoid cell line strongly inhibited cell-mediated anti-tumor immunity directed against syngeneic tumor. However, the suppression was non-specific for the given tumor. The cell line expanded with TCGF expressed a phenotypic characterization of T cells defined by monoclonal anti-Thy-1.2 antibody.
Koyama
S
S
Yoshioka
T
T
Sakita
T
T
Fujimoto
S
S
D000818:Animals; D002460:Cell Line; D005354:Fibrosarcoma / Q000276:immunology*; D007108:Immune Tolerance; D007376:Interleukin-2 / Q000502:physiology*; D051379:Mice; D008805:Mice, Inbred A; D013154:Spleen / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D007376:Interleukin-2