Heritable rare fragile sites in patients with leukemia and other hematologic disorders.
Fragile site studies were performed on a total of 126 patients with leukemia and other hematologic disorders including myelodysplastic syndrome (MDS) and polycythemia vera (PV). Compared with an incidence (6.0%) of heritable rare fragile sites in the healthy population, the frequency was not higher in the patient group (3.2%), as a whole. However, two cases of fra(17)(p12) in MDS appeared fourfold larger than expected for this group of patients. In one case, a homozygous carrier of fra(17)(p12) in PV was also very rarely expected from its population incidence. These findings suggested a possible role of rare fragile sites, at least in the etiology of these preleukemic or myeloproliferative disorders.
Murata
M
M
Division of Epidemiology, Chiba Cancer Center Research Institute, Japan.
Takahashi
E
E
Minamihisamatsu
M
M
Ishihara
T
T
Wong
P
P
Bessho
M
M
Hirashima
K
K
Hori
T
T
D000328:Adult; D000368:Aged; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002886:Chromosomes, Human, Pair 17; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D010375:Pedigree; D011087:Polycythemia Vera / Q000235:genetics*; D011289:Preleukemia / Q000235:genetics
D005819:Genetic Markers