Association between HLA antigens and periodontal disease.
HLA-A, B and DR antigen frequencies were determined in three groups of periodontally diagnosed subjects: 49 patients with rapidly progressive periodontitis, 40 elderly subjects with minimal disease (considered as a resistant group) and 30 young subjects with minimal disease. The relative risk for HLA-A9 (previously reported to be associated with periodontal disease) was 15.5. HLA-A9 was present in 36.7% of the patients and 2.5% of the resistant group. HLA-A10 showed a significantly increased incidence in the resistant group (30.0%) compared to a non-periodontally diagnosed control population (9.0%), and was absent from the patient group. These findings provide additional evidence for the involvement of HLA-A9 in susceptibility to periodontitis, and suggest that A10 may play a role in resistance to the disease.
Amer
A
A
University of Wales College of Medicine, Dental School, Department of Periodontology, Cardiff, U.K.
Singh
G
G
Darke
C
C
Dolby
A E
AE
D000328:Adult; D000367:Age Factors; D010520:Aggressive Periodontitis; D003601:Cytotoxicity Tests, Immunologic; D005787:Gene Frequency; D008040:Genetic Linkage; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D010510:Periodontal Diseases / Q000276:immunology*; D010518:Periodontitis; D012307:Risk Factors
D006680:HLA Antigens; D015234:HLA-A Antigens; C039682:HLA-A10 antigen; C037709:HLA-A9 antigen; D015235:HLA-B Antigens; D006684:HLA-DR Antigens