Histocompatibility antigens in patients with alcoholic liver disease in Scotland and northeastern England: failure to show an association.
A study of HLA-A and B antigens in 248 patients with biopsy diagnosed alcoholic liver disease was conducted to examine for a genetic predisposition to alcohol related liver injury. No statistically significant differences were established for 8 HLA-A and 16 HLA-B antigens between normal healthy controls (n = 342) and patients with alcoholic fatty liver (n = 86), alcoholic hepatitis (n = 63), active alcoholic cirrhosis (n = 64) and inactive alcoholic cirrhosis (n = 35). It is concluded that no HLA-A or B locus genetic susceptibility to alcoholic related injury could be shown.
Mills
P R
PR
Department of Medicine, Royal Infirmary, Glasgow, Scotland.
MacSween
R N
RN
Dick
H M
HM
Hislop
W S
WS
D004739:England; D005235:Fatty Liver, Alcoholic / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006519:Hepatitis, Alcoholic / Q000276:immunology; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000276:immunology; D008108:Liver Diseases, Alcoholic / Q000235:genetics / Q000276:immunology*; D012606:Scotland
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens