[Synergistic action, on the masculinization of female chick embryo gonads, of a graft of embryonic testis and administration of an anti-estrogenic substance (tamoxifen)].
The capability of an embryonic testis graft to induce a male gonadal sex differentiation in genetically female chick embryos was significantly enhanced by the administration of a antiestrogenic drug (tamoxifen). This observation reinforces the view that the experimentally-induced testis differentiation depends chiefly on a inhibition of estrogen influence.
Maraud
R
R
Vergnaud
O
O
Rashedi
M
M
Stoll
R
R
D000818:Animals; D002642:Chick Embryo; D004967:Estrogens / Q000502:physiology*; D005260:Female; D008297:Male; D010053:Ovary / Q000187:drug effects / Q000196:embryology*; D012733:Sex Differentiation / Q000187:drug effects; D013629:Tamoxifen / Q000494:pharmacology*; D013737:Testis / Q000196:embryology / Q000502:physiology* / Q000637:transplantation
D004967:Estrogens; D013629:Tamoxifen
Action synergique, sur la masculinisation des gonades de l'embryon femelle de Poulet, d'une greffe de testicule embryonnaire et de l'administration d'une substance anti-oestrogène (tamoxifène).