title: Screening for cystic fibrosis among newborns in Norway by measurement of serum/plasma trypsin-like immunoreactivity. Results of a 2 1/2-year pilot project.
abstract: A pilot project for neonatal screening for cystic fibrosis (CF) by measuring trypsin-like immunoreactivity (TLI) in liquid serum or plasma samples was carried out in Norway from May 1982 to December 1984. A total of 72,320 newborns was screened. Twelve infants were recalled for sweat testing; 11 were confirmed to have CF. One infant had normal sweat sodium and chloride levels and no clinical symptoms. The incidence of CF in this study was 1:6574, and the recall rate for second blood samples was 0.6%. No false-negative cases have yet been reported. The level of TLI was affected by the use of heparin in plasma preparation, being reduced by about 20% as compared to serum levels.
authors.affiliation: Dept. of Paediatric Research, Rikshospitalet, Oslo, Norway.
authors.forename: P D
authors.initials: PD
authors.lastname: Edminson
authors.forename: H
authors.initials: H
authors.lastname: Michalsen
authors.forename: O
authors.initials: O
authors.lastname: Aagenaes
authors.forename: S O
authors.initials: SO
authors.lastname: Lie
mesh_terms: D003550:Cystic Fibrosis / Q000097:blood / Q000517:prevention & control*; D006801:Humans; D007231:Infant, Newborn; D008403:Mass Screening / Q000379:methods*; D009664:Norway; D010865:Pilot Projects; D011863:Radioimmunoassay; D014357:Trypsin / Q000097:blood*
chemical_list: D014357:Trypsin