title: Characterization of immune effector cells present in early murine decidua.
abstract: It has been suggested that murine decidual cells act as an important immunoregulatory population localized to the pregnant uterus. We have examined early murine decidua to determine if immune effector cells occur in the decidual environment in proximity to the conceptus. High levels of natural killer (NK) cell activity were found consistently in decidual cell suspensions with peak activity occurring on Day 6.5 of gestation. NK activity declined as pregnancy proceeded and was not significant by Day 12.5 of gestation. Decidual cell suspensions did not appear to contain significant numbers of functional B or T effector cells. No antipaternal T-cell response could be demonstrated even in the decidua of immune mice. Lack of T-cell responses was attributed to the absence of T cells from decidua rather than to their inactivation because precursors of cytotoxic T lymphocytes (pCTL) could not be detected in decidual cell suspensions. Furthermore, the levels of pCTL detectable in spleen cell suspensions could not be reduced by mixing spleen cells with 7.5-day decidual cells. These results suggest that B cells and T cells may not occur in early decidua while NK cells are present and regulated independently.
authors.forename: P
authors.initials: P
authors.lastname: Gambel
authors.forename: B A
authors.initials: BA
authors.lastname: Croy
authors.forename: W D
authors.initials: WD
authors.lastname: Moore
authors.forename: R D
authors.initials: RD
authors.lastname: Hunziker
authors.forename: T G
authors.initials: TG
authors.lastname: Wegmann
authors.forename: J
authors.initials: J
authors.lastname: Rossant
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003656:Decidua / Q000166:cytology* / Q000276:immunology; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology; D007121:Immunocompetence; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology; D013997:Time Factors