Inhibition of pregnancy before and after implantation in rats with monoclonal antibody against progesterone.
A monoclonal antibody against progesterone completely blocked pregnancy when rats were injected intraperitoneally at 0.53 mumol/kg/day on days 1 and 2, or on day 11 of a first pregnancy. The antibody was equally effective when injected again during a second pregnancy. There was no evidence for anti-idiotypic antibody production even when the injection of a heterologous (mouse) antibody was repeated in a second pregnancy.
Phillips
A
A
Ortho Research Laboratories, Ortho Pharmaceutical Corporation, Raritan, New Jersey 08869.
Hahn
D W
DW
McGuire
J
J
Wang
M W
MW
Heap
R B
RB
Rider
V
V
Taussig
M J
MJ
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D010064:Embryo Implantation; D005260:Female; D007130:Immunoglobulin Idiotypes / Q000032:analysis; D007274:Injections, Intraperitoneal; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood*; D011374:Progesterone / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000911:Antibodies, Monoclonal; D007130:Immunoglobulin Idiotypes; D011374:Progesterone