The therapeutic effects of dietary fatty acid supplementation in the autoimmune disease of the MRL-mp-lpr/lpr mouse.
The effect of dietary fatty acids on the spontaneous autoimmune disease systemic lupus erythematosus of the MRL-mp-lpr/lpr mouse was investigated after onset of disease. Parameters monitored included auto-antibody levels (by ELISA), proteinuria, body weights, clinical appearance and survival. The preliminary study (using five mice per group) showed that dietary restriction improved survival (P less than 0.001) per se, and further that all mice receiving the fish oil diet benefited considerably (P less than 0.005), whilst males on the fish oil/evening primrose oil diet also lived longer than expected (P less than 0.005).
Watson
J
J
Department of Bioscience and Biotechnology, University of Strathclyde, Glasgow, U.K.
Godfrey
D
D
Stimson
W H
WH
Belch
J J
JJ
Sturrock
R D
RD
D000818:Animals; D001327:Autoimmune Diseases / Q000178:diet therapy*; D004247:DNA / Q000276:immunology; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use*; D002149:Energy Intake; D005227:Fatty Acids / Q000627:therapeutic use*; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000178:diet therapy*; D008297:Male; D051379:Mice; D012737:Sex Factors
D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D005395:Fish Oils; D004247:DNA