The use of ceftriaxone in ambulatory patients.
Twenty ambulatory patients, living in kibbutzim (communal villages, which have a permanent medical staff) were treated with ceftriaxone 1 g daily I.M. for ten days. These patients suffered from moderate to severe infections which were not life-threatening. Twelve had urinary tract infections (UTI), 3 of which were positive blood cultures. Four patients had soft tissue infections (one with a Group A beta-hemolytic Streptococcus bacteremia). Three patients had respiratory infections, and one elderly patient had Salmonella typhimurium gastroenteritis. All the patients in this series were clinically cured. Three patients with a UTI experienced reinfection. The woman with S. typhimurium gastroenteritis had persistent positive fecal cultures, but was asymptomatic. These 4 patients did not require further antibiotic therapy. The only side effect observed was mild diarrhea in one patient. Two other ambulatory patients with typhoid fever were treated with ceftriaxone 2 g daily I.V. for 10 days with excellent results. Our work showed that ceftriaxone 1 g daily can be a safe and inexpensive antimicrobial choice to shorten or prevent hospitalization.
Raz
R
R
Infectious Disease Unit, Central Emek Hospital, Israel.
Kennes
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care; D001424:Bacterial Infections / Q000188:drug therapy*; D002443:Ceftriaxone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D002443:Ceftriaxone