title: [Diabetes insipidus in chronic myeloid leukemia. Remission of hypophyseal infiltration during busulfan treatment].
abstract: In a 53-year-old male who presented with diabetes insipidus as the first symptom of chronic myelocytic leukemia, computed tomography of the sella showed infiltration of the posterior pituitary gland. Busulfan treatment was given for one month and the infiltration had disappeared ten weeks after initiation of therapy. At the same time the severity of the diabetes insipidus diminished for a period of three months. Diabetes insipidus is a rare complication of chronic myelocytic leukemia: only 8 similar cases have been reported in the last 75 years.
authors.affiliation: Departement für Innere Medizin, Medizinische Poliklinik, Universitätsspital Zürich.
authors.forename: P
authors.initials: P
authors.lastname: Eichhorn
authors.forename: K
authors.initials: K
authors.lastname: Rhyner
authors.forename: D
authors.initials: D
authors.lastname: Haller
authors.forename: R
authors.initials: R
authors.lastname: Hämmerli
authors.forename: R
authors.initials: R
authors.lastname: Steuli
authors.forename: J
authors.initials: J
authors.lastname: Furrer
mesh_terms: D002066:Busulfan / Q000627:therapeutic use*; D003919:Diabetes Insipidus / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D012658:Sella Turcica / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D002066:Busulfan
vernacular_title: Diabetes insipidus bei chronischer myeloischer Leukämie. Rückbildung der hypophysären Infiltration unter Busulfan.