The effect of ipriflavone treatment on osteoporosis induced by immobilization.
The purpose of these experiments was to study the effect of Ipriflavone (7 isopropoxy-isoflavone) on the osteoporosis induced by immobilization. The immobilization was produced by plaster cast of the right hind limb in young and old rats. Ipriflavone was administered via a gastric tube in a daily dose of 40 mg/kg body weight for 8 weeks. On the basis of histological and histomorphometric examinations of the tibia, results of Ipriflavone treatment are the following: 1) The decrease in the density and volume of spongy trabecules was less apparent in both meta- and diaphysis; 2) The amount of persisting cartilage core and structural rarefication of trabecules were diminished; 3) In the metaphysis osteoblastic activity was considerably enhanced; 4) Bone resorption and cortical thinning were decreased; 5) Bone remodeling was increased subperiosteally and to small extent also endosteally; 6) The treatment did not prevent the development of osteoporosis but significantly diminished it.
Földes
I
I
Institute of Anatomy, Debrecen University Medical School, Hungary.
Rapcsák
M
M
Szöör
A
A
Gyarmati
J
J
Szilágyi
T
T
D000375:Aging; D000818:Animals; D001846:Bone Development; D001842:Bone and Bones / Q000473:pathology; D005419:Flavonoids / Q000627:therapeutic use*; D007103:Immobilization; D007529:Isoflavones / Q000627:therapeutic use*; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D005419:Flavonoids; D007529:Isoflavones; C018986:ipriflavone