[Interaction between radiopharmaceutical and therapeutic agents. The modification of the distribution of 99mTc-methylene diphosphonate by D-penicillamine].
The effect of D-penicillamine on the distribution of 99mTc-MDP was studied in male Wistar rats. There were significant activity decreases after medication in blood, kidney, lung and skeletal muscle. The activity in the skeleton was not influenced by D-penicillamine. After treatment, the liver showed a significant increase of activity. The clearance of activity not bound to the skeleton altogether accelerates after D-penicillamine medication. It is assumed that the change of kinetics is caused by a complex formation of the radiopharmaceutical and D-penicillamine. D-penicillamine possibly displaces methylene diphosphonate from the 99mTc-complex.
Van de Flierdt
E
E
Stumpf
E
E
Bögl
W
W
D000818:Animals; D004164:Diphosphonates / Q000378:metabolism* / Q000494:pharmacology; D004347:Drug Interactions; D008297:Male; D010396:Penicillamine / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium / Q000378:metabolism* / Q000494:pharmacology; D013669:Technetium Tc 99m Medronate; D013997:Time Factors; D014018:Tissue Distribution
D004164:Diphosphonates; D013667:Technetium; D010396:Penicillamine; D013669:Technetium Tc 99m Medronate
Interaktionen zwischen Radiopharmaka und Therapeutika. Beeinflussung der Verteilung des 99mTc-Methylendiphosphonats durch D-Penicillamin.