[Studies on the metabolic fate of 14C-rokitamycin. Absorption, distribution, metabolism and excretion in infant rats].
14C-Rokitamycin (RKM) at the dose of 200 mg/kg was administered orally to fasted infant rats to study the absorption, distribution, metabolism and excretion in infant animals. The mean blood level of 14C-RKM reached its peak of 20.25 micrograms/ml in 30 minutes. The mean area under the curve was 93.23 micrograms.hr/ml. In vivo plasma protein binding rates of 14C-RKM were about 30% in both infant and adult rats. 14C-RKM was distributed at high concentrations into liver, kidney, lung, spleen, pancreas, bone marrow, submaxillary gland and some other tissues. Major metabolites detected in plasma, urine and bile were 10"-OH-RKM, leucomycin A7, leucomycin V and 14-OH-leucomycin V. In excretion studies, about 97% of the administered radioactivity was recovered in urine and feces within 144 hours. After intraduodenal administration to rats with cannulated bile ducts, 7.42% and 25.66% of the radioactivity were excreted within 24 hours in the urine and bile, respectively.
Sakai
A
A
Department of Pharmaceutics, Kyoto College of Pharmacy.
Iwasaki
M
M
Suzuki
T
T
Morishita
M
M
Muranishi
S
S
D000042:Absorption; D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D001646:Bile / Q000378:metabolism; D007933:Leucomycins / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D008297:Male; D015644:Miocamycin / Q000031:analogs & derivatives*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D007933:Leucomycins; D015644:Miocamycin; C033383:rokitamycin