title: [Electrophoretic detection of protein p53 in human leukocytes].
abstract: Protein (m.v. 53 kilodalton) with electrophoretic mobility identical to that of protein detected in leukocytes of patients with Down's syndrome and of protein p53 obtained from mouse ascites carcinoma was demonstrated by polyacrylamide gel electrophoresis in healthy donors' leukocytes cultured with PHA and in peripheral blood of patients with chronic myeloleukemia. Appearance of the class p53 proteins in leukocytes of patients may be connected with the presence in their blood of the population of immature or transformed, proliferating or merely DNA-synthesizing leukocytes, particularly those amplifying the gene that codes protein p53.
authors.forename: V D
authors.initials: VD
authors.lastname: Paponov
authors.forename: E G
authors.initials: EG
authors.lastname: Shcheglova
authors.forename: N N
authors.initials: NN
authors.lastname: Iarullin
authors.forename: E G
authors.initials: EG
authors.lastname: Kupsik
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000032:analysis*; D002286:Carcinoma, Ehrlich Tumor / Q000032:analysis; D004314:Down Syndrome / Q000097:blood; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood; D007962:Leukocytes / Q000032:analysis*; D051379:Mice; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000032:analysis / Q000097:blood*; D010750:Phosphoproteins / Q000097:blood*; D012995:Solubility; D013053:Spectrophotometry; D016159:Tumor Suppressor Protein p53
chemical_list: D001798:Blood Proteins; D009363:Neoplasm Proteins; D010750:Phosphoproteins; D016159:Tumor Suppressor Protein p53
vernacular_title: Elektroforeticheskoe vyiavlenie belka p53 v leĭkotsitakh cheloveka.