[Hypophosphoremia during mechanical ventilation for chronic obstructive bronchopathies].
Hypophosphoremia may interfere with respiratory function in chronic obstructive pulmonary diseases (COPD) through different mechanisms: muscular exhaustion and weakness. Accordingly, the frequency and magnitude of hypophosphoremia was studied in 36 consecutive patients with acute respiratory failure and mechanical ventilation. Initial phosphoremia was normal (1,32 +/- 0,12 mmol/l) but often and rapidly decreased in all patients after mechanical ventilation had been started (0,54 +/- 0,14 mmol/l after 24 h). After this, phosphoremia remained low, slowly increasing with continued enteral nutrition (2000 Kcal, 276 g of glucides, 33 mmol/l of phosphorus). Four patients had severe hypophosphoremia after 24 h of mechanical ventilation (less than 0,30 mmol/l). Phosphoremia returned to a normal level 36 h after extubation. Hypophosphoremia was closely linked to pH improvement (r = + 0,67, P less than 0,001) and was paralleled by a drop in phosphaturia, suggesting intra-cellular penetration of phosphorus.
Squara
P
P
Bleichner
G
G
Aubier
M
M
Parent
A
A
Sollet
J P
JP
Murciano
D
D
D000138:Acidosis / Q000097:blood; D000368:Aged; D000437:Alcoholism / Q000097:blood; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007676:Kidney Failure, Chronic / Q000097:blood; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000097:blood*; D012121:Respiration, Artificial / Q000009:adverse effects*; D012189:Retrospective Studies; D013997:Time Factors
D010758:Phosphorus
Hypophosphorémie au cours de la ventilation mécanique des bronchopathies chroniques obstructives.