title: Validation of the saline-dilution method for measuring cardiac output by simultaneous measurement with a perivascular electromagnetic flowprobe.
abstract: The validity of measurements of right heart output obtained by the saline-indicator method with a catheter-mounted, tetrapolar resistivity sensor placed in the pulmonary artery was assessed. In ten anesthetized dogs, cardiac output was measured simultaneously by the saline-indicator method, using 5 ml of 3 per cent saline as the indicator, and by a perivascular electromagnetic flowprobe placed around the trunk of the pulmonary artery. Cardiac output was altered over a wide range by increasing the depth of halothane anesthesia and by bolus injections of isoproterenol. Linear regression analysis of cardiac output determined from 455 saline-indicator curves and from simultaneous recordings of the electromagnetic flow signal yielded a slope of 0.973, a Y intercept of -0.0047 1/minute, and a correlation coefficient of 0.965. Hence, this method provides accurate and precise measurement of cardiac output. The saline-indicator method with the catheter-mounted resistivity sensor is simple to use and eliminates or minimizes the disadvantages of other indicator-dilution techniques.
authors.forename: W D
authors.initials: WD
authors.lastname: Voorhees
authors.forename: J D
authors.initials: JD
authors.lastname: Bourland
authors.forename: M L
authors.initials: ML
authors.lastname: Lamp
authors.forename: J C
authors.initials: JC
authors.lastname: Mullikin
authors.forename: L A
authors.initials: LA
authors.lastname: Geddes
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D002302:Cardiac Output; D004285:Dogs; D055590:Electromagnetic Phenomena / Q000295:instrumentation*; D007201:Indicator Dilution Techniques; D011651:Pulmonary Artery / Q000502:physiology; D012212:Rheology; D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride
chemical_list: D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride