[Chemical modification of ristomycin A with bifunctional reagents].
Various bifunctional reagents by the free NH2 group of ristomycinic acid of ristomycin A were used for selective chemical modification of the antibiotic. The bifunctional reagents were the following: di-N-hydroxysuccinimide ether of suberic acid and 4,4'-difluoro-3,3'-dinitrodiphenylsulfone. Bis-N,N'-derivatives of ristomycin A were prepared using these reagents. The derivatives inhibited the growth of Bac. subtilis but the concentrations required for the inhibition were 2-4 times higher than those of ristomycin A. It was noted that the MIC of the bis-N,N'-derivatives depended on the length and flexibility of the "binding foot". The MIC of the bis-N,N'-derivative prepared with using suberic acid was 2 times higher than that of the derivative prepared with the use of 4,4'-difluoro-3,3'-dinitrodiphenylsulfone.
Trifonova
Zh P
ZhP
Sturman
N V
NV
Katrukha
G S
GS
Fedorova
G B
GB
D001412:Bacillus subtilis / Q000187:drug effects; D002210:Caprylates; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003998:Dicarboxylic Acids / Q000494:pharmacology; D004139:Dinitrofluorobenzene / Q000031:analogs & derivatives / Q000494:pharmacology; D004347:Drug Interactions; D007202:Indicators and Reagents / Q000494:pharmacology; D012310:Ristocetin / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013388:Succinimides / Q000494:pharmacology
D002210:Caprylates; D003998:Dicarboxylic Acids; D007202:Indicators and Reagents; D013388:Succinimides; D012310:Ristocetin; C013936:difluorodinitrobenzene sulfone; C016719:ristocetin A; C046781:N-hydroxysuccinimide suberic acid ester; C005738:suberic acid; D004139:Dinitrofluorobenzene
Khimicheskaia modifikatsiia ristomitsina A bifunktsional'nymi reagentami.