[Aldehyde dehydrogenase activity in the barrier brain structures].
The histochemical method was used to study the aldehyde dehydrogenase (EC 1.2.1.3.; ALDH) activity in capillaries and glial structures of different regions in the rat central nervous system (CNS). The occurrence of three metabolic barriers for aldehydes on systemic level in the CNS has been shown. They are: the barrier between blood and the nervous tissue (represented by capillary endothelium and surrounding astrocytes ALDH), that between blood and cerebrospinal fluid (ALDH in ependymocytes of vascular plexus), and that between cerebrospinal fluid and nervous tissue (ALDH of ependymocytes covering brain cavities). On the single microregions level a similar barrier is between interstitial fluid and neurons (ALDH of satellite oligodendrocytes).
Zimatkin
S M
SM
Ostrovskiĭ
Iu M
IuM
D000444:Aldehyde Dehydrogenase / Q000378:metabolism*; D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D051381:Rats; D014018:Tissue Distribution
D000447:Aldehydes; D000444:Aldehyde Dehydrogenase
Aktivnost' al'degiddegidrogenazy v bar'ernykh strukturakh mozga.