title: L-phenylalanine mustard-dianhydrogalactitol and hyponatremia.
abstract: The incidence of hyponatremia in 34 patients following administration of high-dose L-phenylalanine mustard (L-PAM) and dianhydrogalactitol (DAG) was determined. Two consecutive daily levels of 133 mEq/l or less were observed in 12 patients. These episodes coincided with the advent of diarrhea about 10-12 days after drug administration. The hyponatremia was not due to the syndrome of inappropriate antidiuretic hormone secretion.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
authors.forename: L
authors.initials: L
authors.lastname: Helson
authors.forename: M D
authors.initials: MD
authors.lastname: Sadof
authors.forename: G
authors.initials: G
authors.lastname: Wernovsky
authors.forename: S
authors.initials: S
authors.lastname: Gulati
mesh_terms: D003937:Diagnosis, Differential; D003961:Dianhydrogalactitol / Q000009:adverse effects*; D003967:Diarrhea / Q000139:chemically induced / Q000150:complications*; D006801:Humans; D007010:Hyponatremia / Q000175:diagnosis / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D008558:Melphalan / Q000009:adverse effects*; D009423:Nervous System Neoplasms / Q000150:complications / Q000188:drug therapy; D009447:Neuroblastoma / Q000150:complications / Q000188:drug therapy; D011446:Prospective Studies
chemical_list: D003961:Dianhydrogalactitol; D008558:Melphalan