5q- syndrome terminating in acute myeloid leukemia. Karyotype evolution and immunologic characterization of blast cells.
We report a case of 5q- syndrome that progressed to acute nonlymphocytic leukemia after 9 years of clinically and morphologically stable disease. The transition from the chronic to the leukemic phase was characterized by the appearance of an additional cytogenetic anomaly [inv(2)] in the cell carrying the 5q-, together with the expansion of a clone showing an apparently normal karyotype.
Donti
E
E
1st Institute of Internal Medicine, School of Medicine, Perugia University, Italy.
Tabilio
A
A
Donti
G V
GV
Mecucci
C
C
Carotti
A
A
Grignani
F
F
Martelli
M F
MF
D000753:Anemia, Refractory / Q000150:complications / Q000235:genetics* / Q000473:pathology; D000911:Antibodies, Monoclonal; D001752:Blast Crisis / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013577:Syndrome
D000911:Antibodies, Monoclonal