title: 24-Hour/4-hour ratio of technetium-99m methylene diphosphonate uptake in patients with bone metastases and degenerative bone changes.
abstract: The uptake of [99mTc]MDP in metastatic lesions of the vertebrae was compared with the uptake in normal vertebrae. The ratio of these lesion-to-nonlesion uptakes at 4 and 24 hr was called the 24-hr/4-hr ratio (TF ratio). A similar ratio was measured for lesions in the spine due to degenerative bone disease. Lesions in vertebrae with degenerative bone disease and treated metastases had a significantly lower TF ratio than lesions in vertebrae with untreated bone metastases. These findings suggest that the TF ratio might be a reliable method for separating metastatic lesions from degenerative changes in the vertebral column, and could be especially useful in cancer patients whose bone scans demonstrate a single lesion in the spine.
authors.forename: O
authors.initials: O
authors.lastname: Israel
authors.forename: D
authors.initials: D
authors.lastname: Front
authors.forename: A
authors.initials: A
authors.lastname: Frenkel
authors.forename: U
authors.initials: U
authors.lastname: Kleinhaus
mesh_terms: D000328:Adult; D000368:Aged; D004164:Diphosphonates; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D013122:Spinal Diseases / Q000000981:diagnostic imaging*; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D013128:Spinal Osteophytosis / Q000000981:diagnostic imaging; D013667:Technetium; D013669:Technetium Tc 99m Medronate; D013997:Time Factors
chemical_list: D004164:Diphosphonates; D013667:Technetium; D013669:Technetium Tc 99m Medronate