Plasma catecholamines in conscious rabbits after central administration of vasopressin.
Arterial levels of epinephrine (E) were significantly raised for all times sampled, after intracerebroventricular (i.c.v.) injection of arginine vasopressin (AVP) (1 nmol) into conscious rabbits. Venous levels of norepinephrine (NE) were significantly raised within the first 4 min after a similar i.c.v. injection of AVP. The significant increases in arterial E and venous NE correspond in time and therefore could account for changes in heart rate and blood pressure elicited by centrally injected AVP. Therefore, AVP could influence cardiovascular function by increasing the activity of the sympatho-adrenomedullary system.
Martin
S M
SM
Biology Department, Mount Saint Vincent University, Halifax, N.S., Canada.
Malkinson
T J
TJ
Bauce
L G
LG
Veale
W L
WL
Pittman
Q J
QJ
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004837:Epinephrine / Q000097:blood*; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D011817:Rabbits
D001127:Arginine Vasopressin; D009638:Norepinephrine; D004837:Epinephrine