The effects on ventilation of ketorolac in comparison with morphine.
We have compared the effect on ventilation of ketorolac, an injectable non-steroidal analgesic, with that of morphine in a randomized, double-blind, cross-over study, using two doses of ketorolac (10 and 90 mg i.m.) and one of morphine (10 mg i.m.). The effect on ventilation was measured with a CO2 rebreathing technique. As a measure of the effect we studied the increase in PETCO2 (CO2 shift) that caused a respiratory minute volume (RMV) equal to the RMV in the control period at 8 kPa PETCO2. Ketorolac caused insignificant CO2 shifts of about 0.10 kPa, while morphine caused a significant CO2 shift of 0.86 kPa. We conclude that ketorolac in analgesic and supra-analgesic doses has no effect on the ventilatory response to CO2 under circumstances in which significant effects are seen with morphine.
Bravo
L J
LJ
Department of Anesthesiology, University Hospital Leiden, The Netherlands.
Mattie
H
H
Spierdijk
J
J
Bovill
J G
JG
Burm
A G
AG
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002245:Carbon Dioxide; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D020910:Ketorolac; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D011758:Pyrroles / Q000494:pharmacology*; D011897:Random Allocation; D012119:Respiration / Q000187:drug effects*; D014046:Tolmetin / Q000031:analogs & derivatives / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011758:Pyrroles; D002245:Carbon Dioxide; D009020:Morphine; D014046:Tolmetin; D020910:Ketorolac