title: Cytophilic IgE on human blood and tissue eosinophils.
abstract: Flow microfluorometry (FMF) was used to investigate the presence of cytophilic Ig (IgE or IgG) and the proportion of Fc receptor (Fc epsilon R or Fc gamma R)-bearing eosinophils among eosinophils from 21 hypereosinophilic patients. In 75% of the cases, it was possible to detect cytophilic IgE, significantly associated with serum IgE levels. Moreover, when lung and blood eosinophils were compared, the proportion of occupied Fc epsilon R was significantly increased on lung eosinophils, whereas very few cells had cytophilic IgG. This work provides further evidence that cytophilic IgE is not restricted to cells with high-affinity Fc epsilon R but can also be detected on the cell populations with low-affinity IgE receptors. These findings support the view that eosinophils can act as effector cells in immediate hypersensitivity reactions and in diseases associated with increased IgE production and hypereosinophilia.
authors.forename: M
authors.initials: M
authors.lastname: Capron
authors.forename: J P
authors.initials: JP
authors.lastname: Kusnierz
authors.forename: L
authors.initials: L
authors.lastname: Prin
authors.forename: H L
authors.initials: HL
authors.lastname: Spiegelberg
authors.forename: J
authors.initials: J
authors.lastname: Khalife
authors.forename: A B
authors.initials: AB
authors.lastname: Tonnel
authors.forename: A
authors.initials: A
authors.lastname: Capron
mesh_terms: D004802:Eosinophilia / Q000276:immunology*; D004804:Eosinophils / Q000276:immunology*; D005434:Flow Cytometry; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D011961:Receptors, Fc / Q000276:immunology*; D017455:Receptors, IgE; D014018:Tissue Distribution
chemical_list: D011947:Receptors, Antigen, B-Cell; D011961:Receptors, Fc; D017455:Receptors, IgE; D007073:Immunoglobulin E