title: Meta-iodobenzylguanidine scintigraphy in neuroblastoma--a comparison with conventional X-ray and ultrasound.
abstract: To evaluate the accuracy of meta-iodobenzylguanidine (MIBG) imaging in comparison with bone X-ray and ultrasound, 15 patients with histologically verified neuroblastoma were investigated using 123- or 131MIBG scintigraphy. 123MIBG and 131MIBG are used as the abbreviations for 123-iodine-labeled-MIBG and 131-iodine-labeled-MIBG, respectively. Either 7.4 MBq 131MIBG (n = 4) or 111-185 MBq 123MIBG (n = 11) was applied, and scans were performed 24 and 48 h PI. Anatomical orientation was provided in selected cases by single-photon emission CT or scintigraphy of other organs. X-ray procedures or ultrasound depicted 27 neuroblastoma manifestations (primary tumors and metastatic deposits); 24 of these (89%) were identified by MIBG scintigraphy. Of 42 primary neuroblastomas and metastatic deposits, 27 (64%) were detected by corresponding bone X-ray or ultrasound. The 15 neuroblastoma lesions depicted solely by MIBG scans were mainly (80%) situated in the skeletal system. Because of the pronounced physiological MIBG uptake by liver tissue, detection of intrahepatic or perihepatic tumor involvement is difficult. MIBG scintigraphy is a safe and noninvasive means of locating a wide range of neuroblastoma lesions. Its main diagnostic advantage in comparison with bone X-ray lies in the detection of bone marrow infiltration.
authors.affiliation: Department of Nuclear Medicine, University of Hamburg, F.R.G.
authors.forename: H W
authors.initials: HW
authors.lastname: Müller-Gärtner
authors.forename: R
authors.initials: R
authors.lastname: Erttmann
authors.forename: K
authors.initials: K
authors.lastname: Helmke
mesh_terms: D019797:3-Iodobenzylguanidine; D002648:Child; D005069:Evaluation Studies as Topic; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D009447:Neuroblastoma / Q000000981:diagnostic imaging*; D011859:Radiography; D011877:Radionuclide Imaging; D014463:Ultrasonography
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine