title: The effects of quaternary ammonium chloride (alpha C12 DME AHCl) on enamel hardness and mineral loss under intra oral cariogenicity test conditions.
abstract: The effects of a quaternary ammonium compound; 2-hydroxy-ethyl-2-hydroxydodecyl-dimethyl-ammonium chloride (alpha C12 DMEAHCl) on enamel hardness and mineral loss in enamel slabs were studied under intra-oral cariogenicity test conditions. The quaternary ammonium compound without fluoride reduced enamel softening as well as the mineral loss from enamel significantly up to a depth of 100 microns from the surface. Moreover the Ca/P molar ratio of the treated enamel was comparable to untreated enamel controls. These findings suggest that the quaternary ammonium compound itself inhibits mainly demineralisation rather than remineralization under intra-oral cariogenicity test conditions.
authors.affiliation: Department of Prosthetic Dentistry, Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: E J
authors.initials: EJ
authors.lastname: van Croonenburg
authors.forename: J H
authors.initials: JH
authors.lastname: Wöltgens
authors.forename: H
authors.initials: H
authors.lastname: van der Laan
authors.forename: E
authors.initials: E
authors.lastname: Schepens
mesh_terms: D000818:Animals; D002118:Calcium / Q000032:analysis; D002417:Cattle; D003731:Dental Caries / Q000378:metabolism* / Q000503:physiopathology; D003743:Dental Enamel / Q000187:drug effects*; D003747:Dental Enamel Solubility / Q000187:drug effects*; D006244:Hardness; D006801:Humans; D008903:Minerals / Q000378:metabolism; D010758:Phosphorus / Q000032:analysis; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*
chemical_list: D008903:Minerals; D000644:Quaternary Ammonium Compounds; D010758:Phosphorus; C056743:2-hydroxyethyl-2-hydroxydodecyldimethylammonium; D002118:Calcium