Efficacy of progesterone antagonist RU486 (mifepristone) for pre-operative cervical dilatation during first trimester abortion.
A randomized double-blind study (RU486 versus placebo) was carried out in order to investigate whether a progesterone antagonist facilitated surgical abortion in the first trimester of pregnancy. The consistency of the cervix changed significantly after RU486 (P less than 0.02). We conclude that this effect may facilitate cervical dilatation, making first trimester abortion under local anaesthesia more comfortable and less dangerous.
Durlot
F
F
Service de Gynécologie Obstétrique, Hôpital Antoine Béclère, Clamart, France.
Dubois
C
C
Brunerie
J
J
Frydman
R
R
D000019:Abortifacient Agents / Q000627:therapeutic use*; D000021:Abortifacient Agents, Steroidal / Q000627:therapeutic use*; D000028:Abortion, Induced / Q000379:methods*; D002584:Cervix Uteri / Q000187:drug effects*; D004107:Dilatation and Curettage / Q000379:methods*; D004311:Double-Blind Method; D004963:Estrenes / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015735:Mifepristone; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011300:Preoperative Care; D011374:Progesterone / Q000037:antagonists & inhibitors*; D011897:Random Allocation
D000019:Abortifacient Agents; D000021:Abortifacient Agents, Steroidal; D004963:Estrenes; D015735:Mifepristone; D011374:Progesterone