Induction of ornithine decarboxylase activity by 1-oleoyl-2-acetyl-glycerol in isolated mouse epidermal cells.
1-Oleoyl-2-acetyl-glycerol induced a rise in ornithine decarboxylase activity in isolated epidermal cells in a concentration-dependent manner. The time course of the induction of ornithine decarboxylase by 1-oleoyl-2-acetyl-glycerol was similar to that by 12-O-tetradecanoylphorbol-13-acetate. A23187 did not enhance the enzyme induction caused by 1-oleoyl-2-acetyl-glycerol. Palmitoyl-DL-carnitine prevented the induction of the enzyme either by 1-oleoyl-2-acetyl-glycerol or 12-O-tetradecanoyl-phorbol-13-acetate. These results suggest that the activation of protein kinase C is an initial and essential event in the process of ornithine decarboxylase induction caused by 12-O-tetradecanoyl-phorbol-13-acetate.
Sasakawa
N
N
Ishii
K
K
Yamamoto
S
S
Kato
R
R
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004075:Diglycerides / Q000494:pharmacology*; D004790:Enzyme Induction; D004817:Epidermis / Q000187:drug effects / Q000201:enzymology*; D005260:Female; D005989:Glycerides / Q000494:pharmacology*; D051379:Mice; D019301:Oleic Acid; D009829:Oleic Acids / Q000494:pharmacology; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011247:Pregnancy; D011493:Protein Kinase C; D011494:Protein Kinases / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013997:Time Factors
D004075:Diglycerides; D005989:Glycerides; D009829:Oleic Acids; D019301:Oleic Acid; D000001:Calcimycin; C038237:1-oleoyl-2-acetylglycerol; D011494:Protein Kinases; D011493:Protein Kinase C; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate