Influence of an enriched dietary sodium chloride regime during gestation and suckling and post-natally on the ontogeny of hypertension in the rat.
Brattleboro rats without diabetes insipidus were subjected to sodium chloride enrichment (20-fold increase in dietary salt) at various stages of their development. Salt supplementation in the adult rat produced higher systolic blood pressure (SBP), particularly in males (142 +/- 3 versus 110 +/- 3 mmHg in control. The blood pressures of females on salt-supplemented diets during pregnancy decreased from 136 +/- 1 to 121 +/- 2 mmHg, although throughout this period the blood pressures for these rats were greater than for the control pregnant rats. Pregnant females on salt-supplemented diets also showed higher sodium concentrations in the amniotic fluid compared with controls (155 +/- 3.4 versus 134.1 +/- 6.0 mmol/l). Salt supplemented lactating mothers produced milk with similar sodium concentrations to those of the controls, but the urinary sodium concentrations of pups suckling on the former were greater than in the controls. It is concluded that the suckling pups were also salt-enriched. Rats were submitted to salt-enriched regimes in utero, during suckling, post-weaning and post-pubertally, or permutations thereof. Salt supplementation post-weaning led to consistent elevation in arterial blood pressure with males being more susceptible than females. The degree of elevation was increased if the salt-supplement was present during suckling (132 +/- 1 versus 112 +/- 1 mmHg) and was greatest when the salt-supplemented regime was administered both in utero and during the post-weaning period (154 +/- 2 versus 112 +/- 1 mmHg).(ABSTRACT TRUNCATED AT 250 WORDS)
Hazon
N
N
Department of Zoology, University of Sheffield, UK.
Parker
C
C
Leonard
R
R
Henderson
I W
IW
D015070:18-Hydroxydesoxycorticosterone / Q000097:blood; D000450:Aldosterone / Q000097:blood; D000803:Angiotensin I / Q000097:blood; D000818:Animals; D000833:Animals, Suckling; D001794:Blood Pressure / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D005260:Female; D006973:Hypertension / Q000209:etiology*; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011910:Rats, Brattleboro; D012982:Sodium, Dietary / Q000008:administration & dosage / Q000009:adverse effects*; D014886:Weaning
D015070:18-Hydroxydesoxycorticosterone; D012982:Sodium, Dietary; D000450:Aldosterone; D000803:Angiotensin I; D003345:Corticosterone