title: Blood clearance of 99mTc-phytate for evaluation of hepatic dysfunction in dogs.
abstract: Organ distribution pattern, and blood clearance were examined by giving 99mTc-phytate (99mTc-P) to the normal dogs. At the same time, the relation between the severity of hepatic function and blood clearance of 99mTc-P was studied by using the dogs with acute hepatic dysfunction experimentally induced by carbon tetrachloride (CCl4) administration. Furthermore, a comparative discussion on blood clearance test of 99mTc-P was made with serum transaminase test. It appeared appropriate to administer 99mTc-P at the dose of 100 micrograms/kg in order to obtain an effective blood clearance curve. A major part of 99mTc-P intravenously administered was taken up into the liver, while the remainder of small amount into the spleen, kidneys, lung, and so on. Little was recognized in the thyroid. The disappearance rate of 99mTc-P from blood decreased with the increase in dose of CCl4 and with the passage of time after the CCl4 administration. The blood clearance test of 99mTc-P in dogs showed a sensitive reaction for the acute hepatic dysfunction induced by CCl4 equally to the serum transaminase test.
authors.affiliation: Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Shibata
authors.forename: M
authors.initials: M
authors.lastname: Kohno
authors.forename: T
authors.initials: T
authors.lastname: Hisano
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D008107:Liver Diseases / Q000662:veterinary*; D008111:Liver Function Tests / Q000379:methods*; D008657:Metabolic Clearance Rate; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D015609:Organotechnetium Compounds; D010833:Phytic Acid / Q000493:pharmacokinetics; D013667:Technetium / Q000097:blood; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; C026177:technetium phytate; D013667:Technetium; D010833:Phytic Acid; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase