title: [Idiopathic form of late hemorrhagic disease caused by a deficiency of vitamin K. A presentation of 3 cases].
abstract: Three one month old infants with idiopathic late haemorrhagic disease due to vitamin K deficiency are reported. Patients had been exclusively breast fed and had not received vitamin K at birth. Initial symptomatology was typical in the three cases. Two of them had an intracranial haemorrhage with exitus in one of them. Coagulation study showed non measurable levels of PT and PTT and a significant reduction in vitamin K dependent factors. Coagulopathy was corrected with parenteral administration of vitamin K and fresh plasma. Pathogenic factors of this entity are reviewed and present day recommendations to prevent occurrence of this problem are discussed.
authors.affiliation: Departamento de Pediatría, Hospital Nacional M. de Valdecilla, Facultad de Medicina, Santander.
authors.forename: M J
authors.initials: MJ
authors.lastname: Lozano
authors.forename: M
authors.initials: M
authors.lastname: García Fuentes
authors.forename: L
authors.initials: L
authors.lastname: Alvarez Granda
authors.forename: J
authors.initials: J
authors.lastname: Alonso
authors.forename: J
authors.initials: J
authors.lastname: Figols
authors.forename: E
authors.initials: E
authors.lastname: Bureo
mesh_terms: D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D014812:Vitamin K / Q000627:therapeutic use; D014813:Vitamin K Deficiency / Q000150:complications / Q000188:drug therapy; D006475:Vitamin K Deficiency Bleeding / Q000188:drug therapy / Q000209:etiology*
chemical_list: D014812:Vitamin K
vernacular_title: Forma idiopática de la enfermedad hemorrágica tardía por déficit de vitamina K. Presentación de tres casos.