["Diabetic" proliferative retinopathy and nodular glomerulosclerosis without diabetes mellitus].
A 65-year-old woman of normal weight, hospitalized because of pleuritis, was found to have chronic renal failure (creatinine clearance 20 ml/min). Renal biopsy (light and electron-microscopy) revealed nodular glomerulosclerosis (Kimmerstiel-Wilson disease), described as a diabetes-specific renal change. Fundoscopy discovered bilateral proliferative retinopathy as seen in diabetes. But oral and intravenous glucose tolerance tests were normal, excluding a manifest diabetic metabolic disorder. No other cause of the glomerulosclerosis (such as amyloidosis or multiple myeloma) was found. The patient had been overweight for a time when younger, reversed by dieting. It is suggested that the "diabetic" changes in the kidneys and eyes without diabetes could be the result of a transitory disorder of glucose tolerance during the period of obesity.
Biesenbach
G
G
II. Medizinische Abteilung, Allgemeinen Krankenhauses Linz.
Hommer
K
K
Stadler
G
G
Kramar
R
R
Syré
G
G
Zazgornik
J
J
D000368:Aged; D003920:Diabetes Mellitus / Q000175:diagnosis*; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000209:etiology*; D003930:Diabetic Retinopathy / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology*; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D013997:Time Factors
D005947:Glucose
"Diabetische" proliferative Retinopathie und noduläre Glomerulosklerose ohne Diabetes mellitus.