On the role of transferrin in 67Ga uptake by tumor cells.
In vitro uptake of 67Ga-citrate and 59Fe-citrate by DS sarcoma cells in the presence of tumor-bearing animal blood plasma showed a dramatic inhibition of both 67Ga and 59Fe uptakes: about 1/10 of 67Ga and 1/50 of the 59Fe are taken up by the cells. Subcellular fractionation appears to indicate no specific binding to cell structures, and the difference of binding seems to be related to the transferrin chelation and transmembrane transport differences.
Anghileri
L J
LJ
Nuclear Medicine Service, Medical Faculty, University of Nancy, France.
Thouvenot
P
P
Brunotte
F
F
Robert
J
J
D000818:Animals; D002951:Citrates / Q000493:pharmacokinetics*; D019343:Citric Acid; D003470:Culture Media; D066298:In Vitro Techniques; D007504:Iron Radioisotopes / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000097:blood / Q000378:metabolism*; D014168:Transferrin / Q000502:physiology*
D002951:Citrates; D003470:Culture Media; D007504:Iron Radioisotopes; D014168:Transferrin; D019343:Citric Acid