[Effect of exogenous ribose-5-phosphate on the ATP level in a cardiomyocyte culture during "metabolic ischemia" and anoxia].
Addition of ribose-5-phosphate into the incubation medium of primary culture of cardiomyocytes was shown to prevent a decrease in the ATP content under conditions of "metabolic ischemia" and anoxia. Possible mechanisms of ribose-5-phosphate participation in maintaining of the energetic status of myocardial cell in pathological conditions are discussed.
Golubev
M A
MA
Nikulin
I R
IR
Stvolinskaya
N S
NS
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D003327:Coronary Disease / Q000378:metabolism*; D005985:Glyceraldehyde / Q000494:pharmacology; D007773:Lactates / Q000378:metabolism; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D010100:Oxygen / Q000494:pharmacology*; D010427:Pentose Phosphate Pathway; D010428:Pentosephosphates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012267:Ribosemonophosphates / Q000494:pharmacology*
D007773:Lactates; D010428:Pentosephosphates; D012267:Ribosemonophosphates; D005985:Glyceraldehyde; C031626:ribose-5-phosphate; D000255:Adenosine Triphosphate; D010100:Oxygen
Vliianie ékzogennogo ribozo-5-fosfata na uroven' ATF v kul'ture kardiomiotsitov v usloviiakh "metabolicheskoĭ ishemii" i anoksii.