title: Fast atom bombardment mass spectrometry of some anthracycline and bisanthracycline derivatives.
abstract: Fast atom bombardment (FAB) mass spectra of daunomycin, four of its derivatives, seven bisanthracyclines and three mixed-functional daunomycin-acridine derivatives are reported. These anthracyclines all exhibited their expected [MH]+ ions and peaks corresponding to the fragmentations which are characteristic of the anthracycline moiety, and in addition the spectra showed enhanced [MH + n]+ (n = 1-4) ions which were attributed to reductive processes occurring in the liquid matrix under FAB conditions. Daunomycin was also observed to form a dimeric cluster ion [M2H]+ together with associated reduced ions under FAB conditions. We have found that FAB mass spectrometry is an ideal method for the qualitative analysis of large, non-volatile derivatives of anthracyclines.
authors.affiliation: Department of Chemistry, La Trobe University, Bundoora, Victoria, Australia.
authors.forename: C J
authors.initials: CJ
authors.lastname: Chandler
authors.forename: R T
authors.initials: RT
authors.lastname: Brownlee
authors.forename: R J
authors.initials: RJ
authors.lastname: Hook
authors.forename: D R
authors.initials: DR
authors.lastname: Phillips
authors.forename: J A
authors.initials: JA
authors.lastname: Reiss
authors.forename: J A
authors.initials: JA
authors.lastname: Edgar
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000032:analysis*; D003630:Daunorubicin / Q000032:analysis; D004317:Doxorubicin / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D013058:Mass Spectrometry
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; D003630:Daunorubicin