Experimental study of vagotomy for prevention of stress ulcer after hepatectomy of cirrhotic livers. Its influence on hepatic regeneration.
We experimentally studied the influence of vagotomy on hepatic regeneration in rats after hepatectomy of cirrhotic livers. In animals that underwent hepatectomy plus vagotomy the reduction in gastric pH was suppressed, but gastric mucosal blood flow was less than that in control animals that received hepatectomy alone. The suppression of 3H-thymidine uptake percentage and thymidine kinase activity after hepatectomy was more marked in animals treated with hepatectomy plus vagotomy than in controls treated with hepatectomy alone. Hepatic DNA level tended to be lower in animals treated with hepatectomy plus vagotomy than in controls. In animals treated with hepatectomy plus vagotomy, the peak level of the mitotic index was lower and the hepatic regeneration rate was evidently suppressed. These results suggest that it is not appropriate to apply vagotomy, during hepatectomy of cirrhotic livers, for the prevention of postoperative stress ulcer because it causes a marked reduction in gastric mucosal blood flow and suppresses hepatic regeneration.
Urakawa
T
T
First Dept. of Surgery, Kobe University School of Medicine, Japan.
Nagahata
Y
Y
Azumi
Y
Y
Hashimoto
Y
Y
Itoh
A
A
Takeda
K
K
Sano
I
I
Saitoh
Y
Y
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000098:blood supply; D006498:Hepatectomy / Q000009:adverse effects*; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis / Q000601:surgery*; D008115:Liver Regeneration; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological; D014628:Vagotomy
D004247:DNA