title: Relationship between gastric emptying and serum concentrations of emepronium in dogs and human volunteers.
abstract: Clinical trials with increased dosages, relative to the standard regimen, of the anticholinergic drug emepronium (Cetiprin Novum) resulted in a clear improvement in micturition- and urodynamic parameters in urinary incontinent patients. In the present study possible effects on the gastric emptying were tested in dogs and in human volunteers. In dogs a wide dose range of emepronium (5-100 mg/kg p.o.) was used to establish a relationship between serum concentration and effect on the gastric emptying. Gastric emptying was slightly decreased after 25 mg/kg (peak conc. of emepronium about 100 micrograms/l) and markedly decreased after 50 mg/kg (500 micrograms/l) and 100 mg/kg (5000 micrograms/l). In the volunteers no effect of emepronium on gastric emptying was observed, either after 200 mg q.i.d. or after 400 mg q.i.d. (about 3 and 6 mg/kg q.i.d.), which resulted in peak serum concentrations of 100-300 micrograms/l).
authors.affiliation: Department of Pharmacology, R&D, KabiVitrum AB, Stockholm, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Hallén
authors.forename: A
authors.initials: A
authors.lastname: Massey
authors.forename: O
authors.initials: O
authors.lastname: Guilbaud
authors.forename: A
authors.initials: A
authors.lastname: Sundwall
mesh_terms: D000328:Adult; D000818:Animals; D004285:Dogs; D004629:Emepronium / Q000097:blood / Q000494:pharmacology*; D000431:Ethanol / Q000097:blood; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*
chemical_list: D000644:Quaternary Ammonium Compounds; D004629:Emepronium; D000431:Ethanol