title: Enhancement of sensitivity of fluorescence line narrowing spectrometry for detection of carcinogen-DNA adducts.
abstract: Fluorescence line narrowing (FLN), is a method by which highly characteristic spectra have been obtained for a large number of polycyclic aromatic hydrocarbon (PAH)-DNA adducts and is well suited for the analysis of exposures to complex mixtures of PHA. The basic method is described and recent improvements discussed which overcome one of the major limitations of the method to its wider application to biological samples, that is its sensitivity.
authors.affiliation: Ames Laboratory, Department of Energy, Iowa State University.
authors.forename: R
authors.initials: R
authors.lastname: Jankowiak
authors.forename: R S
authors.initials: RS
authors.lastname: Cooper
authors.forename: D
authors.initials: D
authors.lastname: Zamzow
authors.forename: G J
authors.initials: GJ
authors.lastname: Small
authors.forename: G
authors.initials: G
authors.lastname: Doskocil
authors.forename: A M
authors.initials: AM
authors.lastname: Jeffrey
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D051379:Mice; D011083:Polycyclic Compounds / Q000378:metabolism; D013050:Spectrometry, Fluorescence
chemical_list: D002273:Carcinogens; D011083:Polycyclic Compounds; D004247:DNA