title: Insights on the mechanism of balloon valvuloplasty in aortic stenosis.
abstract: An analysis of the mechanisms of action of balloon valvuloplasty in adult aortic stenosis (AS), based on postmortem studies on fresh specimens and on clinical experience with 300 consecutive cases, is reported. When maximally inflated, a 20-mm diameter balloon (occupying a 3.14 cm2 cross-sectional area) significantly enlarges the stenosed valve orifice by 3 mechanisms: stretching of valve tissue, rupturing of commissural fusion and breaking of calcific deposits. These last 2 mechanisms are the most effective, in both tricuspid and bicuspid forms of AS, to render the cusps more flexible and able to open during systole and to close at the time of ventricular diastole. The marked increase in valve area obtained by the dilatation procedure was clearly demonstrated on fresh postmortem specimens and also on postmortem examination of cases that had had balloon valvuloplasty during life. Stretching alone may give only a temporary increase in valve area with an elastic return of the leaflets to their initial stenosing position and may explain, at least in part, the occurrence of restenosis. Inflation of the balloon is well tolerated with no deleterious decrease in blood pressure in two-thirds of the cases because the balloon opens the commissures, allowing blood ejection through these openings. It does not produce calcific emboli, probably because calcium deposits remain imbedded in the leaflets, covered by the endothelium. Finally, it very infrequently produces acute severe aortic regurgitation. Careful choice of balloon size is necessary to obtain on effective opening; most often a 20-mm diameter balloon but sometimes a balloon up to 23 mm is used.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Service de Cardiologie, Centre Hospitalo-Universitaire, Hôpital Charles-Nicolle, Rouen, France.
authors.forename: B
authors.initials: B
authors.lastname: Letac
authors.forename: L I
authors.initials: LI
authors.lastname: Gerber
authors.forename: R
authors.initials: R
authors.lastname: Koning
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000473:pathology / Q000503:physiopathology; D001022:Aortic Valve Insufficiency / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D001794:Blood Pressure; D002114:Calcinosis / Q000473:pathology; D002404:Catheterization / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012421:Rupture