title: Immunologic aspects of German shepherd dog pyoderma (GSP).
abstract: In 21 dogs with clinical features of German Shepherd dog Pyoderma (GSP) parameters of the specific and aspecific immune system have been examined. Chemotaxis and killing capacities of neutrophilic leucocytes were undisturbed, whereas in skin biopsies no specific immunoglobulin or complement deposits were found with immunofluorescence. With double immunodiffusion, antibodies against Gram-positive bacteria were found. In a laser nephelometric assay significantly elevated levels of IgG, IgGab, IgGd, IgM and bacterial components, associated and non-associated with circulating immune complexes, were detected. However, no relation was found with the disease state. It is concluded that dogs with GSP are immunologically normal reactors. A bacterial hypersensitivity reaction is hypothesized as a possible initiating factor in the pathogenesis of GSP.
authors.affiliation: Department of Dermatology, State University of Utrecht, The Netherlands.
authors.forename: M A
authors.initials: MA
authors.lastname: Wisselink
authors.forename: W E
authors.initials: WE
authors.lastname: Bernadina
authors.forename: A
authors.initials: A
authors.lastname: Willemse
authors.forename: A
authors.initials: A
authors.lastname: Noordzij
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000378:metabolism; D000942:Antigens, Bacterial / Q000032:analysis; D003165:Complement System Proteins / Q000378:metabolism; D004283:Dog Diseases / Q000209:etiology / Q000276:immunology*; D004285:Dogs; D005260:Female; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D006098:Granulocytes / Q000276:immunology; D007136:Immunoglobulins / Q000378:metabolism; D007428:Intradermal Tests; D008297:Male; D011711:Pyoderma / Q000209:etiology / Q000276:immunology / Q000662:veterinary*
chemical_list: D000907:Antibodies, Bacterial; D000936:Antigen-Antibody Complex; D000942:Antigens, Bacterial; D007136:Immunoglobulins; D003165:Complement System Proteins