A potent dopamine-releasing factor is present in high concentrations in the rat adrenal gland.
The present study shows that a novel, protease-sensitive factor present in a partially purified preparation from the rat adrenal gland selectively stimulates the release of dopamine from the rat striatal tissue superfused in vitro in a dose-dependent manner. Biological activity is also found to be present in much lower concentrations in the neocortex, striatum and cerebellum but absent in liver or spleen. This putative dopamine releasing factor is probably a glycoprotein, resistent to boiling, partially inactivated by trypsin and completely inactivated by the non-specific protease pronase E.
Chang
G D
GD
Department of Physiology and Biophysics, University of Illinois, Urbana 61801.
Ramirez
V D
VD
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000311:Adrenal Glands / Q000378:metabolism*; D000313:Adrenal Medulla / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006023:Glycoproteins / Q000378:metabolism* / Q000494:pharmacology; D066298:In Vitro Techniques; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008970:Molecular Weight; D051381:Rats
D002395:Catecholamines; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; C058043:dopamine-releasing factor, rat; D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine