[Salivary 17-hydroxyprogesterone concentration in monitoring of the treatment of congenital adrenal hyperplasia].
The salivary concentration of 17-hydroxyprogesterone (17-OHP) was determined in 11 patients (aged 6 months to 13 years) with congenital adrenogenital syndrome (AGS) due to C21-hydroxylase deficiency and six healthy controls, in order to assess its value in monitoring treatment of AGS. Salivary 17-OHP was measured by a specific radioimmunoassay after extraction with dichloromethane. Only 100 microliters of saliva was needed for the assay. There was a good correlation (r = 0.93; P less than 0.01) between 17-OHP concentrations in paired saliva and serum samples from the patients and the control subjects. There was a wide scatter in salivary 17-OHP levels in the range between 164 ng/l (1.7 ng/ml in serum) of satisfactorily or overtreated patients and 15,500 ng/l (247 ng/l in serum) of undertreated patients. Levels in normal children were between 200 and 300 ng/l. It is concluded that treatment of congenital AGS (21-hydroxylase deficiency) can be carefully monitored in children with the noninvasive, frequently repeatable measurement of salivary 17-OHP.
Arisaka
O
O
Abteilung für Pädiatrie, Juntendo Medizinische Universitätsklinik, Tokio, Japan.
Shimura
N
N
Nakayama
Y
Y
Arisaka
M
M
Yabuta
K
K
D019326:17-alpha-Hydroxyprogesterone; D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005438:Fludrocortisone / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D006908:Hydroxyprogesterones / Q000032:analysis* / Q000097:blood; D007223:Infant; D008297:Male; D008991:Monitoring, Physiologic; D011863:Radioimmunoassay; D012463:Saliva / Q000032:analysis*
D006908:Hydroxyprogesterones; D019326:17-alpha-Hydroxyprogesterone; D005438:Fludrocortisone; D006854:Hydrocortisone
Speichel-17-Hydroxyprogesteron-Konzentration zur Therapieüberwachung bei angeborener Nebennierenhyperplasie.