Sleep-promoting effect following intracerebroventricular injection of a phosphorylated analogue of delta sleep-inducing peptide (DSIP-P) in rats.
The effect of phosphorylated delta sleep-inducing peptide (DSIP-P) on sleep of rats was studied. DSIP-P (20 or 200 pmol/kg) was injected into the third cerebroventricle of male rats immediately before the onset of the dark period of a 12:12 h light-dark cycle. DSIP-P resulted in increases of slow-wave sleep (SWS) (17.3%, P less than 0.01) and paradoxical sleep (PS) (32.3%, P less than 0.05) during the subsequent dark period without shortening sleep latency in the dose of 200 pmol/kg. The SWS-promoting effect was carried over to the next light period. These changes returned to control levels on the second day. These results indicate that DSIP-P is a long-lasting sleep-promoting substance in rats.
Nakagaki
K
K
Department of Psychology, Tokyo Metropolitan Institute for Neurosciences, Fuchu City, Japan.
Ebihara
S
S
Usui
S
S
Honda
Y
Y
Takahashi
Y
Y
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D003701:Delta Sleep-Inducing Peptide / Q000008:administration & dosage*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects
D003701:Delta Sleep-Inducing Peptide