Effect of ovarian steroids on migration of uterine lumenal neutrophils and on chemokinetic factors in uterine secretions from mares.
Incubation of blood neutrophils with uterine flushings collected from ovariectomised mares treated with oestradiol, stimulated migration under agarose, whereas flushings from mares treated with progesterone or oily vehicle, inhibited migration. After intra-uterine infusion of bacteria, however, flushings from oestradiol-treated and vehicle-treated mares inhibited migration, whereas progesterone treatment stimulated migration. Migration of uterine-derived neutrophils under agarose was less than that of blood neutrophils and was not influenced by treatment with ovarian steroids. Uterine susceptibility to infection in progesterone-treated mares was not, therefore, correlated with the migratory activities of uterine neutrophils or the chemokinetic properties of uterine secretions in vitro.
Watson
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ED
Department of Veterinary Medicine, University of Bristol, Langford.
D000818:Animals; D002464:Cell Migration Inhibition; D002630:Chemotactic Factors / Q000502:physiology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006734:Horse Diseases / Q000382:microbiology / Q000503:physiopathology; D006736:Horses / Q000502:physiology*; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D011374:Progesterone / Q000494:pharmacology*; D013290:Streptococcal Infections / Q000503:physiopathology / Q000662:veterinary; D014591:Uterine Diseases / Q000382:microbiology / Q000503:physiopathology / Q000662:veterinary; D014599:Uterus / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism
D002630:Chemotactic Factors; D011374:Progesterone; D004958:Estradiol