Comparison of the effects of carbamazepine and oxcarbazepine on peripheral nerve conduction.
Twenty-five epileptic outpatients were studied to assess possible effects of the first 6 months of treatment with carbamazepine or oxcarbazepine using serial peripheral nerve conduction measurements. Carbamazepine caused a small slowing effect on the motor conduction of the median nerve after 4 weeks of treatment, and the effect was correlated with the fasting serum concentration of the drug. Slowed motor conduction value of the median nerve was also observed after 6 months of treatment with carbamazepine. Oxcarbazepine did not cause any statistically significant slowing of nerve conduction.
Danner
R
R
Department of Clinical Neurophysiology, University of Kuopio, Finland.
Partanen
J
J
Keränen
T
T
Reinikainen
K
K
Hallikainen
E
E
Riekkinen
P
P
D000293:Adolescent; D000328:Adult; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004311:Double-Blind Method; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects*; D000078330:Oxcarbazepine; D010525:Peripheral Nerves / Q000187:drug effects / Q000503:physiopathology*
D002220:Carbamazepine; D000078330:Oxcarbazepine