Does PEPCK play a key role in amino acid oxidation?
The major role of phosphoenolpyruvate carboxykinase (PEPCK) in gluconeogenesis is well known. However, studies on amino acid metabolism indicate that this enzyme may also play an important role in complete oxidation of amino acids by several tissues. Here we review evidence to support this proposition, focussing on experiment performed on glutamine metabolism in immune tissues and white adipose tissue.
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Departamento de Fisiologia e Biofísica, Universidade de São Paulo, Brasil.
D000273:Adipose Tissue / Q000201:enzymology*; D000818:Animals; D002262:Carboxy-Lyases / Q000502:physiology*; D005943:Gluconeogenesis; D005973:Glutamine / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008198:Lymph Nodes / Q000201:enzymology; D008264:Macrophages / Q000201:enzymology; D010084:Oxidation-Reduction; D010730:Phosphoenolpyruvate Carboxylase / Q000502:physiology*; D051381:Rats
D005973:Glutamine; D002262:Carboxy-Lyases; D010730:Phosphoenolpyruvate Carboxylase