Comparative activity of cefotetan against plasmid-encoded aminoglycoside-resistant enterobacteria strains.
304 strains of R-plasmid harbouring enterobacteria resistant to aminoglycosides were studied for their susceptibilities to a range of antibiotics, including cefotetan. Cefotetan and latamoxef were the most active of the four cephamycins tested and all were stable to the beta-lactamases produced by these strains. No new beta-lactamases (SHV-2, CTX-1, TEM-4, CAZ-1) were found in these strains capable of hydrolysing third generation cephalosporins. The activity of cefotetan against these multi-resistant, beta-lactamase producing strains may be of clinical value.
Gomez-Lus
R
R
Department of Microbiology, University Hospital, Zaragoza, Spain.
Otal
I
I
Gomez-Lus
M L
ML
Sarraseca
C
C
Castillo
J
J
Gil
J
J
Rubio
M C
MC
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015313:Cefotetan / Q000494:pharmacology*; D002513:Cephamycins / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009070:Moxalactam / Q000494:pharmacology; D011815:R Factors
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002513:Cephamycins; D015313:Cefotetan; D009070:Moxalactam