[Effect of glucocorticoids on the Ca2+ concentration in the cytoplasm of thymocytes].
Using the fluorescent dye, quin-2, it was shown that the addition of cortisol, dexamethasone (10(-5)-10(-4) M) to the suspension of rat thymocytes results in 1.5-3-fold increase of free Ca2+ concentration in the cytoplasm (intracellular Ca2+). The hormone-stimulated increase of intracellular Ca2+ fails to occur if extracellular Ca2+ concentration is sharply reduced by using calcium-free buffer.
Dukhanin
A S
AS
D000634:Aminoquinolines; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003593:Cytoplasm / Q000187:drug effects* / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects* / Q000378:metabolism
D000634:Aminoquinolines; D005938:Glucocorticoids; D003907:Dexamethasone; C035739:Quin2; D002118:Calcium; D006854:Hydrocortisone
Vliianie gliukokortikoidov na kontsentratsiiu Ca2+ v tsitoplazme timotsitov.