[Prognostic significance of the onset of infection in newborn infants].
Between September 86 and May 87 we reviewed the case histories of 25 newborns (gestational age: 33-41 weeks, birth weight: 1280-3600 g) with septicaemia proved by positive blood cultures. Two groups are formed: Group A: onset of sepsis within the first 48 hours of life (10 newborns), group B: onset of sepsis after 48 hours of life (15 newborns). No differences in gestational age and birth weight were found between the groups. Amnionitis was found in 8 mothers (80%) of group A, however, we found only 2 (13%) mothers with amnionitis in group B. All patients in group A had signs of the respiratory distress syndrome and their clinical condition was poor. Only the CRP was helpful in the laboratory diagnosis of septicaemia. In group B sepsis was diagnosed in 11 (73%) patients by means of a raised CRP and an increased immature neutrophil count. Only 4 patients of this group showed clinical deterioration. The following bacteria were cultured: Group A: E. coli 4, b-streptococci 3, Klebsiella 3. Group B: Staph, aureus 8, Strept. faecalis 5, Pseudomonas 2. In group A 3 patients died and 3 patients developed meningitis with neurological sequelae. In group B non of the patients died, but 2 patients developed osteomyelitis.
Salzer
H R
HR
Universitäts-Kinderklinik, Wien.
Genger
H
H
Weninger
M
M
Pollak
A
A
D001419:Bacteria / Q000302:isolation & purification; D002821:Chorioamnionitis / Q000382:microbiology; D003428:Cross Infection / Q000382:microbiology* / Q000401:mortality; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000382:microbiology* / Q000401:mortality; D011247:Pregnancy; D011379:Prognosis; D018805:Sepsis / Q000382:microbiology* / Q000401:mortality
Prognostische Bedeutung des Beginnes einer Sepsis beim Neugeborenen.