Perinatal complications and reduced size of brain limbic structures in familial schizophrenia.
Both genetic and nongenetic risk factors for schizophrenia have been described. Specifically, perinatal complications have been suggested as a factor in the later development of schizophrenia. These appear to be increased among schizophrenic patients with a clear genetic vulnerability for illness. While reduced brain tissue localized to the temporal lobe is also present in these individuals, it is unknown whether brain structural differences are a consequence of perinatal insults to the developing brain. Initial analyses on magnetic resonance imaging scans from siblings with schizophrenia are presented in an attempt to examine this issue.
DeLisi
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Dept. of Psychiatry, SUNY, Stony Brook 11794.
Dauphinais
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Gershon
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D000328:Adult; D000679:Amygdala / Q000473:pathology; D001925:Brain Damage, Chronic / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000473:pathology*; D008032:Limbic System / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D007744:Obstetric Labor Complications / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology*; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology; D012565:Schizophrenic Psychology