Prolonged survival time of sarcoma 180-bearing mice treated with lipid microspheres-entrapped antitumor marine coral prostanoids.
Antitumor marine coral prostanoids (clavulone II and chlorovulone I) were entrapped into lipid microspheres of 0.2 micron diameter to make lipo-drugs. Daily treatment with lipo-chlorovulone I (1.6 mg/kg/day, i.p.) and lipo-clavulone II (12.5 mg/kg/day, i.p.) on days 1 through 5 markedly prolonged the survival time (135% ILS and 73% ILS, respectively) of mice inoculated with sarcoma 180 as compared with that of a corresponding dose of respective free chlorovulone I and clavulone II. These results suggest that lipid microspheres may be used as drug delivery carriers for antitumor coral prostanoids in vivo.
Honda
A
A
Department of Biochemistry, Tokyo College of Pharmacy, Japan.
Mori
Y
Y
Yamada
Y
Y
Nakaike
S
S
Hayashi
H
H
Otomo
S
S
D000818:Animals; D004337:Drug Carriers; D008055:Lipids; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008863:Microspheres; D011454:Prostaglandins A / Q000008:administration & dosage*; D012510:Sarcoma 180 / Q000188:drug therapy*
D004337:Drug Carriers; D008055:Lipids; D011454:Prostaglandins A; C057742:chlorovulone I; C057741:clavulone II