Translocations t(15;17) and t(9;14)(q34;q22) in a case of acute promyelocytic leukemia with increased number of basophils.
A patient with a variant form of acute promyelocytic leukemia (M3 variant) associated with an increased number of basophils was found to present a reciprocal translocation, t(9;14)(q34;q22) in addition to t(15;17)(q22;q12). Although several cases of acute nonlymphocytic leukemia with increased bone marrow and peripheral blood basophils have been reported, this is the first case in which both the t(9;14) and basophilia were observed in a patient with M3. Our findings support the hypothesis that 9q34 may be associated with the chromosomal location of genes regulating the production and maturation of basophils.
Gotoh
H
H
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Murakami
S
S
Oku
N
N
Itoh
K
K
Takeda
N
N
Fujita
N
N
Shimazaki
C
C
Nishio
A
A
Haruyama
H
H
Nakagawa
M
M
D000328:Adult; D001491:Basophils / Q000473:pathology*; D002883:Chromosomes, Human, Pair 14; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007621:Karyotyping; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics* / Q000473:pathology; D007958:Leukocyte Count; D008297:Male; D014178:Translocation, Genetic