title: [Drug ototoxicity. Medicolegal aspects].
abstract: Drug ototoxicity is a preoccupying iatrogenic complication. Experimental studies over recent years, in particular a pharmacokinetic study of the elimination of aminoglycosides, have enabled the authors to define rules of prescription for parenteral aminoglycosides designed to reduce to a minimum the risk associated with their use. New aminoglycosides such as Netromycin appear to be associated with reduced toxicity. The medico-legal consequences of this complication are still rare, although more precise rules of prescription tend to make the experts more rigorous. The experimental evidence of cochleovestibular toxicity of aminoglycosides applied locally in the presence of a perforated tympanum leaves no room for doubt. The principal factor seems to be the duration of treatment. The prescription of a local aminoglycoside in the presence of a perforated tympanum would only appear to be justified from a legal point of view when absolutely indicated by antibiotic sensitivity tests.
authors.affiliation: Service d'Oto-Rhino-Laryngologie CHI de Montfermeil.
authors.forename: A
authors.initials: A
authors.lastname: Hazan
authors.forename: J P
authors.initials: JP
authors.lastname: Senechaut
authors.forename: B
authors.initials: B
authors.lastname: Cohen
authors.forename: G
authors.initials: G
authors.lastname: Senechal
authors.forename: C
authors.initials: C
authors.lastname: Peytral
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003638:Deafness / Q000139:chemically induced*; D005601:Framycetin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007049:Iatrogenic Disease; D008318:Malpractice
chemical_list: D000900:Anti-Bacterial Agents; D005601:Framycetin
vernacular_title: L'ototoxicité médicamenteuse. Aspects médico-légaux.