Effects of pentoxifylline on pulmonary hemodynamics during acute hypoxia in anesthetized dogs.
The effects of pentoxifylline on pulmonary hemodynamics were studied in anesthetized dogs during acute alveolar hypoxia. In Series A, 7 dogs received pentoxifylline orally (18 mg/kg/day) for 11 wk and 7 untreated dogs served as control animals. During anesthesia and controlled ventilation, acute alveolar hypoxia was induced (10 to 13% inspired O2) and pulmonary and systemic hemodynamic and blood rheologic measurements were compared with normoxia. In control dogs, cardiac index did not change during hypoxia, but pulmonary vascular resistance index (PVRI) increased 79%, erythrocyte filterability decreased significantly (p less than 0.05), and relative viscosity of blood corrected for hematocrit did not change. In the pentoxifylline-treated dogs, cardiac index increased 28% and PVRI increased only 20%; in contrast to the control dogs, relative viscosity of blood was decreased by 18% and no significant changes in filterability were observed. The increase in PVRI in relation to the drop in arterial O2 saturation was significantly larger (p less than 0.05) in the control dogs. Pentoxifylline also increased P50 by 2.8 mm Hg (p less than 0.05). In Series B, hemodynamic measurements were made during variations in blood flow (induced by restricting venous return) in 3 treated (26 mg/kg/day for 3 wk) and 3 control dogs. In these experiments, pulmonary artery pressure was significantly lower at comparable flows during both normoxia and hypoxia. In both studies, the hemodynamic effects of the drug on the systemic circulation were less than on the pulmonary circulation.(ABSTRACT TRUNCATED AT 250 WORDS)
Chick
T W
TW
Section of Pulmonary Medicine, Veterans Administration Medical Center, Albuquerque, NM 87108.
Scotto
P
P
Icenogle
M V
MV
Sikes
C W
CW
Doyle
M P
MP
Riedel
C E
CE
Wood
S C
SC
Loeppky
J A
JA
D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D004907:Erythrocyte Deformability / Q000187:drug effects; D005260:Female; D006400:Hematocrit; D006439:Hemodynamics / Q000187:drug effects*; D000860:Hypoxia / Q000097:blood / Q000503:physiopathology*; D008297:Male; D010100:Oxygen / Q000097:blood; D010431:Pentoxifylline / Q000494:pharmacology*; D011652:Pulmonary Circulation / Q000187:drug effects*; D013805:Theobromine / Q000031:analogs & derivatives*; D014655:Vascular Resistance / Q000187:drug effects
D013805:Theobromine; D010100:Oxygen; D010431:Pentoxifylline