[Pharmacokinetic aspects of anticonvulsant therapy with benzonal].
Major pharmacokinetic parameters of the Soviet anticonvulsive drug benzobarbital used with different regimens of administration (single and prolonged) are described. The authors have studied the interrelationship between benzobarbital and carbamazepine when these drugs are used in combination and drawn a conclusion as to their weak pharmacokinetic synergism. On the basis of the established pharmacokinetic parameters a number of practical inferences pertaining to the mode of benzobarbital administration have been made.
Okudzhava
V M
VM
Chanvetadze
B G
BG
Antadze
Z I
ZI
Chkhenkeli
S I
SI
Rukhadze
M D
MD
D000927:Anticonvulsants / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001463:Barbiturates / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001923:Brain Chemistry; D002220:Carbamazepine / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use; D002849:Chromatography, Gas; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D012463:Saliva / Q000032:analysis; D013997:Time Factors
D000927:Anticonvulsants; D001463:Barbiturates; D002220:Carbamazepine; C002915:benzobarbital
Nekotorye farmakokineticheskie aspekty protivosudorozhnoĭ terapii benzonalom.