Recurrence of antigen-induced otitis media by thiol compound.
Reduced glutathione (GSH), a potential factor in the chronicity of human otitis media, was tested to determine its potency in the recurrence of antigen-induced otitis media in chinchillas sensitized with human serum albumin (HSA). GSH instillation into the healing middle ear bulla reproduced a level of otitis media similar to the original antigen-induced otitis media with cellular involvement occurring earlier, according to cytologic analyses. This study indicates that GSH is probably a factor in recurrent antigen-induced otitis media, controlling the balance between thiol proteases and thiol protease inhibitors during middle ear inflammation.
Hamaguchi
Y
Y
Department of Otolaryngology, University of Minnesota, School of Medicine, Minneapolis.
Juhn
S K
SK
Sakakura
Y
Y
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002682:Chinchilla; D005978:Glutathione / Q000276:immunology*; D007700:Kinetics; D010034:Otitis Media with Effusion / Q000276:immunology* / Q000378:metabolism; D012008:Recurrence; D012709:Serum Albumin / Q000276:immunology / Q000378:metabolism
D001798:Blood Proteins; D012709:Serum Albumin; D005978:Glutathione