Biliary excretion of phenprocoumon and metabolites.
To evaluate phenprocoumon elimination its possible biliary excretion was evaluated in addition to the known pathway of renal elimination. Bile samples were obtained during diagnostic endoscopy in patients receiving chronic phenprocoumon therapy and were analyzed for phenprocoumon and its metabolites by HPLC and GC-MS. The following substances were detected, mainly in conjugated form: unchanged phenprocoumon and the metabolites 7-hydroxy-, 4'-hydroxy-, and 6-hydroxy-phenprocoumon. The data provide direct evidence of the biliary elimination of unchanged phenprocoumon and its metabolites in humans.
de Vries
J X
JX
Division of Clinical Pharmacology, University of Heidelberg, Federal Republic of Germany.
Raedsch
R
R
Völker
U
U
Walter-Sack
I
I
Weber
E
E
D015110:4-Hydroxycoumarins / Q000032:analysis*; D000368:Aged; D001646:Bile / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005704:Gallbladder / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010644:Phenprocoumon / Q000032:analysis* / Q000378:metabolism / Q000652:urine
D015110:4-Hydroxycoumarins; D010644:Phenprocoumon