Simulation of CFU-s kinetics after irradiation.
A simulation model of the CFU-s population is used to interpret data from experimental studies of bone marrow recovery after irradiation. The model includes an original hypothesis that the proliferation rate in the CFU-s population depends on the number of DNA-synthesizing CFU-s. It is assumed that the DNA-synthesizing CFU-s produce a factor in the presence of which CFU-s enter the resting state G0 after mitosis and remain there for prolonged periods of time. The model can adequately reproduce complex CFU-s kinetics observed after severe damage caused by irradiation with a unique set of parameters.
Hauser
F
F
Hybrid Computation Laboratory, Institute for Social Medicine and Organization of Health Services, Prague, Czechoslovakia.
Necas
E
E
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D001854:Bone Marrow Cells; D002455:Cell Division; D003198:Computer Simulation; D004247:DNA / Q000096:biosynthesis; D004307:Dose-Response Relationship, Radiation; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000528:radiation effects*; D007399:Interphase; D007700:Kinetics; D008433:Mathematics; D051379:Mice; D008938:Mitosis
D004247:DNA