title: [Interaction of liposomes with vascular endothelial cells].
abstract: Confluent monolayers (3 days old) of cultured calf aortic endothelial cells (line BKEz-7) were incubated for 30, 60 or 120 min with liposomes (reverse-phase evaporation vesicles) in order to investigate by electron microscopy whether and how they interact. This study demonstrates such interactions on a large scale. Electron micrographs show different ways by which liposomes interact with vascular endothelial cells. The observed mechanisms are adsorption, fusion, endocytosis and a transcellular passage of intact liposomes.
authors.affiliation: Akademie der Wissenschaften der DDR, Institut für Wirkstofforschung, Berlin-Friedrichsfelde.
authors.forename: J
authors.initials: J
authors.lastname: Zipper
authors.forename: D
authors.initials: D
authors.lastname: Sarrach
authors.forename: W
authors.initials: W
authors.lastname: Halle
mesh_terms: D000327:Adsorption; D000818:Animals; D002417:Cattle; D004705:Endocytosis; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000648:ultrastructure; D008081:Liposomes / Q000378:metabolism*; D008854:Microscopy, Electron
chemical_list: D008081:Liposomes
vernacular_title: Wechselwirkung von Liposomen mit Gefässendothelzellen.