title: Drug-protein interactions. On the protein-protein interaction induced by levamisole in vitro. A mechanism hypothesis.
abstract: In the present communication, a model is reported in order to explain the aggregation of albumin induced by levamisole in vitro. The hypothesis suggests that the process of polymerization of albumins may include ligand-protein interaction as a biochemical catalysis, and covalent protein-protein interactions by a mechanism of disulfide-sulfhydryl interchange by intramolecular or intermolecular reactions.
authors.affiliation: Unité de Formation et de Recherche de Pharmacie, Université Joseph Fourier Grenoble, Meylan, France.
authors.forename: M
authors.initials: M
authors.lastname: Chicault
authors.forename: C
authors.initials: C
authors.lastname: Luu Duc
authors.forename: A
authors.initials: A
authors.lastname: Boucherle
mesh_terms: D000418:Albumins / Q000378:metabolism*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D007978:Levamisole / Q000494:pharmacology*; D008024:Ligands; D008956:Models, Chemical; D011108:Polymers; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D000418:Albumins; D008024:Ligands; D011108:Polymers; D013438:Sulfhydryl Compounds; D007978:Levamisole