title: 1-Methyl-3-phenyl-1,2,4-triazinium-5-olate: a new zwitterion with cytotoxic activity against human cancer cell-lines.
abstract: One of 6 newly synthesized triazinium zwitterions (JR-1--JR-6) was shown to induce 51Cr-release from leukemic (HL60 and CEM) and solid tumor (MM170 and HeLa) cell-lines. Leukemic cells were more sensitive to this compound than solid tumors as demonstrated by dose-response and time-course studies. Other experiments showed that JR-6 (1-methyl-3-phenyl-1,2,4-triazinium-5-olate) significantly suppressed protein, RNA and DNA synthesis at tumoricidal concentrations.
authors.affiliation: Department of Child Health, Mater Children's Hospital, South Brisbane, Australia.
authors.forename: V
authors.initials: V
authors.lastname: Vuddhakul
authors.forename: N W
authors.initials: NW
authors.lastname: Jacobsen
authors.forename: S E
authors.initials: SE
authors.lastname: Rose
authors.forename: B
authors.initials: B
authors.lastname: Ioannoni
authors.forename: W K
authors.initials: WK
authors.lastname: Seow
authors.forename: Y H
authors.initials: YH
authors.lastname: Thong
mesh_terms: D000970:Antineoplastic Agents; D002455:Cell Division; D002460:Cell Line / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007938:Leukemia; D008545:Melanoma; D014227:Triazines / Q000138:chemical synthesis / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D014227:Triazines; C057604:1-methyl-3-phenyl-1,2,4-triazin-5-one