[Pericardial effusion during the therapy of Crohn's disease with 5-aminosalicylic acid].
A 22-year-old woman with Crohn's disease was treated with 5-aminosalicylic acid (Claversal), four times 500 mg daily, because of increased inflammatory activity. Retrosternal pain set in after two weeks; in another two weeks a moderately enlarged heart was noted on the chest X-ray and pericardial effusion diagnosed echocardiographically. After stopping the medication the pericardial effusion resolved without further treatment. Immunoserology failed to demonstrate autoantibodies, but a repeat lymphocyte stimulation test was positive. There is a possible causal relationship between 5-aminosalicylic acid medication and the pericardial effusion, although the pathogenetic mechanisms is not known.
Weber
P
P
Abteilung I und II, Universität Tübingen.
Becker
E W
EW
Jenss
H
H
D000328:Adult; D000636:Aminosalicylic Acids / Q000009:adverse effects*; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D019804:Mesalamine; D010490:Pericardial Effusion / Q000139:chemically induced* / Q000175:diagnosis; D013997:Time Factors
D000636:Aminosalicylic Acids; D019804:Mesalamine
Perikarderguss während der Therapie eines Morbus Crohn mit 5-Aminosalicylsäure.