Novel antifungal antibiotics octacosamicins A and B. I. Taxonomy, fermentation and isolation, physico-chemical properties and biological activities.
Two antifungal antibiotics octacosamicins A and B were isolated from the culture broth of a strain of actinomycetes, which was identified as a strain of Amycolatopsis. These antibiotics were isolated by resin adsorption and purified by column chromatography and preparative HPLC. Both antibiotics were found to be new substances from their physico-chemical properties. They showed broad antifungal spectra.
Dobashi
K
K
Institute of Microbial Chemistry, Tokyo, Japan.
Matsuda
N
N
Hamada
M
M
Naganawa
H
H
Takita
T
T
Takeuchi
T
T
D000192:Actinomycetales / Q000145:classification* / Q000378:metabolism; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D006146:Guanidines
D000935:Antifungal Agents; D006146:Guanidines; C058021:octacosamicin B; C058020:octacosamicin A