Spontaneous tumors in aging (C57BL/6N x C3H/HeN)F1 (B6C3F1) mice.
Spontaneous tumors in untreated (C57BL/6N x C3H/HeN)F1 (B6C3F1) mice used as controls in carcinogenicity tests were recorded. In both sexes, the development of spontaneous tumors was age-related. In 244 male mice, the most common tumors were hyperplastic nodules of the liver, hepatocellular carcinomas, malignant lymphomas/leukemias, lung adenomas, and adenocarcinomas. In 246 female mice, the most common tumors were malignant lymphomas/leukemias, pituitary adenomas, neoplastic nodules of the liver, hepatocellular carcinomas, and lung adenomas. Hepatocellular carcinomas metastasized in 20.3% of the animals with these tumors. Few other tumors except malignant lymphomas and leukemias metastasized. Various tumors of other organs and/or tissues were found at low incidences.
Tamano
S
S
First Department of Pathology, Nagoya City University Medical School, Japan.
Hagiwara
A
A
Shibata
M A
MA
Kurata
Y
Y
Fukushima
S
S
Ito
N
N
D000367:Age Factors; D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009369:Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000662:veterinary*; D012376:Rodent Diseases / Q000453:epidemiology* / Q000401:mortality; D012737:Sex Factors