title: Carotid sinus baroreceptor control of splanchnic resistance and capacity.
abstract: The contribution of the splanchnic vascular bed in the carotid sinus baroreceptor reflex control of vascular resistance and capacity was studied in nine pentobarbital-anesthetized dogs. The splanchnic circulation was vascularly isolated in an unopened abdomen and perfused at constant flow and venous pressure. Decreasing carotid sinus pressure from 200 to 50 mmHg resulted in a 72% increase in splanchnic vascular resistance and a decrease in splanchnic blood volume of 4.7 ml/kg. Changes in splanchnic inflow from 0 to 70 ml.min-1.kg-1 resulted in linear changes in splanchnic arterial pressure. Increasing carotid sinus pressure significantly decreased the slope (P less than 0.005) and intercept (P less than 0.025) of the splanchnic pressure-flow relationship. It is concluded that in the dog, the splanchnic vascular bed contributes a major portion of blood volume mobilized by the carotid sinus reflex.
authors.affiliation: Department of Surgery, University of Maryland at Baltimore 21201.
authors.forename: M J
authors.initials: MJ
authors.lastname: Brunner
authors.forename: A S
authors.initials: AS
authors.lastname: Greene
authors.forename: A E
authors.initials: AE
authors.lastname: Frankle
authors.forename: A A
authors.initials: AA
authors.lastname: Shoukas
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D002346:Carotid Sinus / Q000502:physiology*; D004285:Dogs; D008297:Male; D011311:Pressoreceptors / Q000502:physiology*; D013152:Splanchnic Circulation; D014655:Vascular Resistance