title: Cardiorespiratory and sedative effects of a combination of acepromazine, xylazine and methadone in the horse.
abstract: Cardiorespiratory and sedative effects of a combination of acepromazine, xylazine and methadone were studied in the horse. Acepromazine and xylazine produced cardiovascular effects whereas methadone mainly affected respiratory rate. Decreases in heart rate, arterial blood pressure and respiratory rate were seen. Sedation was superior to that of acepromazine, xylazine or a combination of these. No serious side effects were seen.
authors.affiliation: Department of Clinical Radiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Nilsfors
authors.forename: C
authors.initials: C
authors.lastname: Kvart
authors.forename: P
authors.initials: P
authors.lastname: Kallings
authors.forename: J
authors.initials: J
authors.lastname: Carlsten
authors.forename: U
authors.initials: U
authors.lastname: Bondesson
mesh_terms: D000075:Acepromazine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006736:Horses / Q000502:physiology*; D007275:Injections, Intravenous; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*; D013843:Thiazines / Q000494:pharmacology*; D014991:Xylazine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D013843:Thiazines; D014991:Xylazine; D000075:Acepromazine; D008691:Methadone