In vivo exposure to ozone causes increased in vitro responses of small airways.
We examined the effects of in vivo exposure to 3 ppm ozone on in vitro reactivity of large and small airways from dogs. No effects in large airways were detected. However, small airways exposed to O3 had larger responses to receptor-mediated stimuli and similar responses to KCl plus phorbol ester. These results suggest that small airways are more vulnerable to O3 inhalation than are large airways and that receptor-mediated pathways reflect that sensitivity. Another possible explanation is that O3 exposure prevents the epithelium from playing its normal dampening role in responses to contractile agonists.
Beckett
W S
WS
Division of Environmental Physiology, School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Black
C
C
Turner
C
C
Spannhake
E W
EW
Menkes
H A
HA
D000818:Animals; D001980:Bronchi / Q000187:drug effects* / Q000502:physiology; D002217:Carbachol / Q000494:pharmacology; D004285:Dogs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D010126:Ozone / Q000494:pharmacology*; D010703:Phorbol Esters / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology
D010703:Phorbol Esters; C008874:phorbol-12,13-diacetate; D011189:Potassium Chloride; D010126:Ozone; D006632:Histamine; D002217:Carbachol