Doxycycline in combination chemotherapy of a rat leukemia.
Inhibition of mitochondrial protein synthesis by doxycycline (DC), a tetracycline analogue, has significant antitumor effects in several tumor systems. In the present study, the effects of continuous DC treatment combined with intermittent administration of Adriamycin or 1-beta-D-arabinofuranosyl cytosine on the growth of a rat leukemia were investigated. The presence of DC retards tumor relapse after 1-beta-D-arabinofuranosyl cytosine or Adriamycin treatment significantly. DC may therefore be of value in several modalities of antitumor treatment.
Van den Bogert
C
C
Laboratory of Physiological Chemistry, State University Groningen, The Netherlands.
Dontje
B H
BH
Kroon
A M
AM
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004318:Doxycycline / Q000008:administration & dosage*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D051381:Rats
D003561:Cytarabine; D004317:Doxorubicin; D004318:Doxycycline