[Effect of alpha- and gamma-tocopherols on the cytochrome P-450 system in the liver of rats with E-avitaminosis. Effectiveness of liposomal forms of gamma-tocopherol].
The effects of low doses of intraperitoneally injected alpha- and gamma-tocopherols dispersed in isotonic solutions of NaCl and of liposomal gamma-tocopherol on endogenous lipid peroxidation and the cytochrome P-450 system of vitamin E-deficient rats were compared. It was found that all tocopherol preparations under study caused a twofold decrease of the lipid Schiff base concentration in the liver in comparison with tocopherol-deficient rats. However, the increase in cytochrome P-450 and b5 levels and the high functional activity of the microsomal oxidation system in the benz(a)pyrene hydroxylation reaction was induced only after liposomal gamma-tocopherol injection. It was concluded that the efficiency of the liposomal form of gamma-tocopherol can be conditioned both by preventing gamma-tocopherol oxidation in lecithin vesicles during its transport and/or by an increased liposomal gamma-tocopherol uptake by the liver from the circulating blood.
Lokshina
E A
EA
Abishev
B Kh
BKh
Sagindykova
S E
SE
Aĭdarkhanov
B B
BB
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004337:Drug Carriers; D015227:Lipid Peroxidation / Q000187:drug effects*; D008081:Liposomes; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000378:metabolism / Q000627:therapeutic use*; D014811:Vitamin E Deficiency / Q000188:drug therapy / Q000201:enzymology*
D004337:Drug Carriers; D008081:Liposomes; D014810:Vitamin E; D003577:Cytochrome P-450 Enzyme System
Vliianie alpha- i gamma-tokoferolov na sistemu tsitokhroma P-450 v pecheni E-avitaminoznykh krys. Effektivnost' liposomal'noĭ formy gamma-tokoferola.