The effect of cyclosporin A on the course of Paragonimus miyazakii infection in rats.
The effect of the immunomodulatory fungal metabolite cyclosporin A (CyA) on the course of Paragonimus miyazakii infection in rats was studied. Administration of CyA 15 to 19 days post-infection resulted in a significantly lower recovery rate of worms and cyst formation in the host's lungs than in controls. Administration of CyA -1 to +3 days post-infection enhanced the growth and maturation of P. miyazakii, expressed as weight of worms and the number of worms with eggs in uteri with respect to control values. This study shows that administration of CyA to rats affects the host-parasite relationship, depending on the time of administration of the drug.
Hashiguchi
Y
Y
Department of Parasitology, Kochi Medical School, Japan.
Okamura
Y
Y
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004334:Drug Administration Schedule; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D010237:Paragonimiasis / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
D003524:Cyclosporins; D007166:Immunosuppressive Agents