Azidothymidine-induced depression of murine hemopoietic progenitor cells.
The toxicity of the antiviral drug 3'-azido-3'-deoxythymidine was studied in vivo on murine hemopoietic progenitor cells and peripheral blood cells. The drug induced a marked decrease of all tested populations, showing a severe toxicity on hemopoiesis.
Bogliolo
G
G
Istituto Scientifico di Medicina Interna, University of Genoa, Italy.
Lerza
R
R
Mencoboni
M
M
Saviane
A
A
Pannacciulli
I
I
D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D001854:Bone Marrow Cells; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D015215:Zidovudine / Q000494:pharmacology*
D015215:Zidovudine