title: Plasma and synovial fluid meclofenamic acid concentrations in patients with rheumatoid arthritis of the knee.
abstract: We have measured plasma and synovial fluid concentrations of meclofenamic acid at 2, 4, 8, and 12 h during steady-state administration (100 mg three times daily for 4-7 days). Paired plasma and synovial samples were obtained pre-treatment and at one of the above times in twelve patients with a diagnosis of rheumatoid arthritis. In addition, the extent of protein binding of meclofenamic acid was assessed in vitro in the pre-treatment plasma and synovial fluid specimens. Peak total concentrations of 1.73 and 0.86 micrograms.ml-1 were observed in plasma (at 2 h) and synovial fluid (at 4 h) respectively. The extent of protein binding was 99.7 and 99.6% (not significantly different) in plasma and synovial fluid respectively. The results of this study are compared to those from similar reported studies of other nonsteroidal anti-inflamatory compounds.
authors.affiliation: Parke-Davis Pharmaceutical Research Division, Warner-Lambert Co., Ann Arbor, MI.
authors.forename: J R
authors.initials: JR
authors.lastname: Koup
authors.forename: D
authors.initials: D
authors.lastname: Thomas
authors.forename: E
authors.initials: E
authors.lastname: Tucker
authors.forename: A
authors.initials: A
authors.lastname: Black
authors.forename: M
authors.initials: M
authors.lastname: Ruderman
authors.forename: J A
authors.initials: JA
authors.lastname: Dixon
authors.forename: A
authors.initials: A
authors.lastname: Kinkel
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D007719:Knee Joint; D008297:Male; D008469:Meclofenamic Acid / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D008875:Middle Aged; D011485:Protein Binding; D013582:Synovial Fluid / Q000032:analysis*; D062367:ortho-Aminobenzoates / Q000032:analysis*
chemical_list: D062367:ortho-Aminobenzoates; D008469:Meclofenamic Acid