Biochemical aspects on adverse reactions to contrast media. Changes of kininogen levels in dog plasma after intravenous injections of iohexol, iopamidol, and iothalamate.
The adverse reactions to contrast media have been investigated by several authors but the exact mechanisms have not yet been established. To study whether kinin-releasing systems are involved in these adverse reactions, we determined total plasma kininogen levels at intervals up to 30 minutes after the intravenous injections of contrast media in dogs. Injections of iohexol, iopamidol, and iothalamate decreased total plasma kininogen levels. This effect increased with increasing dose of the media and suggests that they activated the kinin-releasing systems in the plasma.
Tanaka
T
T
Department of Radiology, School of Medicine, Juntendo University, Tokyo, Japan.
Katayama
H
H
Shirakata
A
A
Takahasi
H
H
D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D004285:Dogs; D007472:Iohexol / Q000009:adverse effects*; D007479:Iopamidol / Q000009:adverse effects*; D007483:Iothalamic Acid / Q000009:adverse effects*; D007704:Kininogens / Q000097:blood*
D003287:Contrast Media; D007704:Kininogens; D007483:Iothalamic Acid; D007472:Iohexol; D007479:Iopamidol