[Comparative clinico-morphological research on measles and mumps infections in an experiment on guinea pigs].
The pathological process typical of measles and mumps infections was reproduced clinically and morphologically in 250 experimental guinea pigs infected into the anterior eye chamber with different strains of measles and mumps viruses. The intraocular inoculation of measles virus induced in guinea pigs the signs of iridocyclitis and follicular conjunctivitis, whereas inoculation of mumps virus induced dacryoadenitis as well as iridocyclitis and follicular conjunctivitis. The severity of the reproduced process and its dynamics correlated with the pathogenicity of measles and mumps virus strains used in the experiment. The specificity of pathological changes observed in the eye structures was verified virologically by the isolation of virus from the eye membranes and the presence of virus-neutralizing antibodies in the blood sera of the animals.
Rozina
E E
EE
khudaverdian
O E
OE
Shteĭnberg
L Sh
LSh
D000818:Animals; D004195:Disease Models, Animal; D005123:Eye / Q000382:microbiology / Q000473:pathology; D006168:Guinea Pigs; D007639:Keratoconjunctivitis, Infectious / Q000382:microbiology / Q000473:pathology; D008457:Measles / Q000382:microbiology / Q000473:pathology*; D008459:Measles virus / Q000302:isolation & purification / Q000472:pathogenicity; D009107:Mumps / Q000382:microbiology / Q000473:pathology*; D009109:Mumps virus / Q000302:isolation & purification / Q000472:pathogenicity; D013997:Time Factors; D014606:Uveitis, Anterior / Q000382:microbiology / Q000473:pathology
Sravnitel'nye kliniko-morfologicheskie issledovaniia korevoĭ i parotitnoĭ infektsiĭ v éksperimente na morskikh svinkakh.