Methanol intoxication. Parkinsonism and decreased Met-enkephalin levels due to putaminal necrosis.
Due to methanol intoxication, a 38-year-old male developed permanent parkinsonism with visual impairment. Brain computerized tomography (CT) and magnetic resonance imaging (MRI) revealed cystic resorption of the putamen. An alteration of the central noradrenergic activity and the opioid system can be assumed because of increased dopamine beta-hydroxylase (D beta H) activity and decreased methionine-enkephalin (Met-Enk) levels in the cerebrospinal fluid (CSF).
Verslegers
W
W
Department of Neurology, Algemeen Ziekenhuis Middelheim, Antwerp, Belgium.
Van den Kerchove
M
M
Crols
R
R
De Potter
W
W
Appel
B
B
Lowenthal
A
A
D000328:Adult; D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000139:chemically induced* / Q000000981:diagnostic imaging; D004744:Enkephalin, Methionine / Q000134:cerebrospinal fluid; D006801:Humans; D008297:Male; D000432:Methanol / Q000506:poisoning*; D009336:Necrosis; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D011699:Putamen / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D014786:Vision Disorders / Q000139:chemically induced; D014920:Wine / Q000506:poisoning*
D004744:Enkephalin, Methionine; D000432:Methanol