Burst firing induced in midbrain dopamine neurons by stimulation of the medial prefrontal and anterior cingulate cortices.
Extracellular recordings were obtained from mesencephalic dopamine neurons in urethane-anesthetized rats. A population of neurons responded to electrical stimulation of the frontal cortex with bursts of action potentials. These bursts resembled those that occur spontaneously in midbrain dopamine neurons with regard to length, interspike interval and post-burst inhibition. This is the first afferent input known to elicit bursting in dopamine neurons.
Gariano
R F
RF
Department of Neuroscience, School of Medicine, University of California San Diego, La Jolla 92093.
Groves
P M
PM
D000200:Action Potentials; D000818:Animals; D004298:Dopamine / Q000502:physiology*; D004558:Electric Stimulation; D005625:Frontal Lobe / Q000502:physiology*; D006179:Gyrus Cinguli / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D006220:Haloperidol; D004298:Dopamine