Effect of nitroxazepine on bone marrow cells of mice.
The antidepressant drug, nitroxazepine, was tested in mice for mutagenicity in bone marrow cells by a micronucleus test. The drug was administered orally at a dose of 4.5, 9, and 13.5 mg per mouse. The results show that the drug is found to be mutagenic in mouse bone marrow cells.
Shaheen
S
S
Department of Genetics, Osmania University, Hyderabad, India.
Rao
K P
KP
Rao
M S
MS
D000284:Administration, Oral; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects*; D003989:Dibenzoxazepines / Q000633:toxicity*; D004912:Erythrocytes / Q000187:drug effects; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens
D000929:Antidepressive Agents, Tricyclic; D003989:Dibenzoxazepines; D009153:Mutagens; C100140:sintamil