The effects of kaolin on the lung.
We studied the prevalence of ventilatory impairment, chest symptoms, and radiographic abnormality in a selected sample of more than 2,000 kaolin workers from east central Georgia. The presence of ventilatory impairment was related to the presence of complicated pneumoconiosis, employment in clay calcining, and cigarette smoking. In those working with calcined clay, there was an increased prevalence of abnormality of the FEV1, but not the FVC, when compared to both wet and dry processors and which could not be explained by either cigarette smoking or the presence of pneumoconiosis. The magnitude of abnormality in the calcined clay workers was, however, unlikely to lead to disabling impairment. In workers with more than 3-yr tenure, there were 90 subjects with simple pneumoconiosis and 18 with complicated pneumoconiosis, yielding an adjusted prevalence of 3.2% and 0.63%, respectively, in the sample examined. Dry processing was associated with a greater risk of developing pneumoconiosis than wet processing.
Morgan
W K
WK
Department of Medicine, University of Western Ontario, London, Canada.
Donner
A
A
Higgins
I T
IT
Pearson
M G
MG
Rawlings
W
W
D000328:Adult; D004391:Dust / Q000009:adverse effects; D005541:Forced Expiratory Volume; D006801:Humans; D007616:Kaolin / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D011009:Pneumoconiosis / Q000139:chemically induced / Q000503:physiopathology; D013902:Radiography, Thoracic; D012140:Respiratory Tract Diseases / Q000139:chemically induced / Q000503:physiopathology; D014797:Vital Capacity
D004391:Dust; D007616:Kaolin