Progesterone increases glomerular filtration rate, urinary kallikrein excretion and uric acid clearance in normal women.
In pregnancy there is a rise in glomerular filtration rate (GFR), plasma aldosterone levels, uric acid clearance and urinary kallikrein excretion. In toxemia all the above parameters tend to decrease. Progesterone has a diuretic effect which is usually related to aldosterone antagonism. We administered progesterone to normal women and observed that GFR, uric acid clearance and kallikrein excretion increased significantly, GFR from 103.0 +/- 13.7 ml/min to 118.0 +/- 18.0 ml/min (P less than 0.01), uric acid clearance from 9.0 +/- 3.6 ml/min to 14.3 +/- 4.0 ml/min (P less than 0.01), and urinary kallikrein excretion from 165 +/- 156 mU to 432 +/- 220 mU (P less than 0.01). Natriuresis and potassium excretion also increased from 15.9 +/- 6.4 mEq to 33.4 +/- 10.9 mEq (P less than 0.01) and from 7.6 +/- 2.7 mEq to 14.0 +/- 5.4 mEq, (P less than 0.01), respectively, suggesting that in this situation aldosterone antagonism is not relevant to explain the diuretic effects of progesterone.
Atallah
A N
AN
Departamento de Medicina, Escola Paulista de Medicina, São Paulo, Brasil.
Guimarães
J A
JA
Gebara
M
M
Sustovich
D R
DR
Martinez
T R
TR
Camano
L
L
D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D007610:Kallikreins / Q000652:urine*; D007668:Kidney / Q000503:physiopathology; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy / Q000502:physiology*; D011374:Progesterone / Q000494:pharmacology*; D014527:Uric Acid / Q000378:metabolism*
D014527:Uric Acid; D011374:Progesterone; D007610:Kallikreins