Changes of secretory ameloblasts in mini-pig fetuses exposed to ethanol in vivo.
After addition of ethanol to the ordinary fodder of pregnant mini-pigs, ultrastructural changes were found in secretory ameloblasts from tooth germs of their mid-term fetuses. Compared with controls, many mitochondria showed abnormal shape and size, and some exhibited deposition of paracrystalline material in the matrix. An abnormal deposition of stippled material intercellularly was also observed. These changes were interpreted as signs of an abnormal secretory function.
Matthiessen
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ME
Anatomy Department A, Panum Institute, University of Copenhagen, Denmark.
Rømert
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P
D000565:Ameloblasts / Q000187:drug effects* / Q000648:ultrastructure; D000566:Amelogenesis / Q000187:drug effects; D000818:Animals; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects* / Q000648:ultrastructure; D013552:Swine; D013556:Swine, Miniature; D014083:Tooth Germ / Q000196:embryology* / Q000648:ultrastructure
D000431:Ethanol