title: Retinol transfer across and between phospholipid bilayer membranes.
abstract: The transfer of retinol across and between bilayer membranes was studied in vitro using unilamellar liposomes and erythrocytes. Transmembrane movement of retinol in phospholipid bilayer membranes was a spontaneous and rapid process with a halflife of less than 30 s. Retinol transfer between liposomes and between liposomes and erythrocytes was also a spontaneous and rapid process with a halflife of less than 10 min. The results suggest that retinol transport in the cell might not need the participation of specific transfer proteins.
authors.affiliation: Department of Clinical Chemistry, Malmö General Hospital, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Fex
authors.forename: G
authors.initials: G
authors.lastname: Johannesson
mesh_terms: D000426:Alcohol Dehydrogenase / Q000378:metabolism; D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D006207:Half-Life; D008051:Lipid Bilayers / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism; D010539:Permeability; D010743:Phospholipids; D013552:Swine; D014801:Vitamin A / Q000493:pharmacokinetics*
chemical_list: D008051:Lipid Bilayers; D008081:Liposomes; D010743:Phospholipids; D014801:Vitamin A; D000426:Alcohol Dehydrogenase