Left ventricular relaxation and filling pattern in diabetic heart muscle disease: an echocardiographic study.
In order to study left ventricular function digitized M-mode-echocardiograms were analyzed. 34 patients with insulin-dependent diabetes mellitus (mean age 37.8 years, mean diabetes history 21.5 years) were compared with 35 healthy individuals (mean age 40.9 years). Only patients with negative exercise-ECG, normal 2-D-echocardiogram and normal systemic arterial blood pressure were enclosed. In diabetics the time-constant Te of free wall endocardial retraction was significantly prolonged (76.8 +/- 21.2 ms versus 64.0 +/- 7.9 ms in normals, p less than 0.005), the dimension change during early diastole (dD DS-ERF) was significantly reduced (54.5 +/- 13.1% versus 69.8 +/- 9% in normals, p less than 0.001) and the dimension change during atrial contraction phase (dD ACP) was significantly enlarged (23.4 +/- 14.4% versus 14.3 +/- 6.4% in normals, p less than 0.001). These data suggest that impaired left ventricular diastolic function can be found in patients with long standing insulin-dependent diabetes mellitus.
Park
J W
JW
Städtisches Krankenhaus und Diabetes-Forschungsinstitut München-Schwabing.
Ziegler
A G
AG
Janka
H U
HU
Doering
W
W
Mehnert
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D002302:Cardiac Output; D009202:Cardiomyopathies / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D004452:Echocardiography / Q000295:instrumentation; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008838:Microcomputers; D008875:Middle Aged; D009200:Myocardial Contraction