Effects of perivascular nerve stimulation on the flow rate in isolated epicardial coronary arteries of pigs.
The effect of perivascular nerve stimulation on coronary contraction was examined by perfusing the isolated epicardial coronary artery of pigs. Coronary flow decreased in a frequency-dependent manner after electrical stimulation, with a maximum percent flow reduction of 23.8 +/- 1.1% (n = 10) at 20 Hz. The reduction in flow rate was not inhibited by phentolamine nor propranolol but was inhibited by atropine. Neostigmine enhanced the flow reduction induced by nerve stimulation. Acetylcholine reduced the flow rate dose dependently but norepinephrine showed no effect. We conclude that perivascular nerve stimulation of the epicardial coronary artery of pigs causes a modest flow reduction through activation of a cholinergic mechanism.
Furusho
N
N
Department of Pharmacology, Kumamoto University Medical School, Japan.
Araki
H
H
Sakaino
N
N
Nishi
K
K
Miyauchi
Y
Y
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000294:innervation*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D010646:Phentolamine / Q000494:pharmacology; D013552:Swine
D002800:Cholinesterase Inhibitors; D000109:Acetylcholine; D010646:Phentolamine