title: Antitussive properties of levodropropizine.
abstract: The antitussive activity of levodropropizine (S(-)-3-(4-phenyl-piperazin-1-yl)-propane-1,2-diol, DF 526), was evaluated in anaesthetized guinea-pigs and rabbits and in unanaesthetized guinea-pigs. Levodropropizine was shown to have good antitussive activity. Intravenously, it was 1/10 to 1/20 as active as codeine and comparable to dropropizine, from which it is derived, on mechanically and electrically induced coughing in rabbits and guinea-pigs. After oral administration to the guinea-pig the antitussive activity of levodropropizine was comparable with those of both dropropizine and codeine against coughing induced by irritant aerosols.
authors.affiliation: Research & Development Laboratories, Dompé Farmaceutici S.p.A., Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Malandrino
authors.forename: G
authors.initials: G
authors.lastname: Melillo
authors.forename: A
authors.initials: A
authors.lastname: Bestetti
authors.forename: M
authors.initials: M
authors.lastname: Borsa
authors.forename: P
authors.initials: P
authors.lastname: Giuliani
authors.forename: G C
authors.initials: GC
authors.lastname: Tonon
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000996:Antitussive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003061:Codeine / Q000008:administration & dosage / Q000627:therapeutic use; D003371:Cough / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D006168:Guinea Pigs; D007275:Injections, Intravenous; D008297:Male; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use; D011409:Propylene Glycols / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits
chemical_list: D000996:Antitussive Agents; D010879:Piperazines; D011409:Propylene Glycols; C013341:zipeprol; C035916:dipropizine; D003061:Codeine