Translocation (2;7)(p13;q36) in a case of acute nonlymphocytic leukemia evolving from a myelodysplastic syndrome.
A case of acute nonlymphocytic leukemia with a new translocation, t(2;7)(p13;q36), as the sole karyotypic abnormality is reported. The patient's leukemia evolved from a cytogenetically normal myelodysplastic syndrome of 4 years' duration. Following treatment the patient entered complete remission with loss of the cytogenetically abnormal clone. Subsequent bone marrow analyses showed recurrence of the myelodysplastic syndrome with a normal karyotype. Although both chromosomes 2 and 7 are known to be involved in nonrandom karyotypic changes in human cancer and leukemia, t(2;7)(p13;q36) has not been reported previously.
Sreekantaiah
C
C
Department of Genetics, Roswell Park Memorial Institute, Buffalo, NY.
Baer
M R
MR
Solé
F
F
Preisler
H D
HD
Sandberg
A A
AA
D000368:Aged; D002871:Chromosome Banding; D002889:Chromosomes, Human, Pair 2; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000235:genetics*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000235:genetics*; D014178:Translocation, Genetic