Transfer of phospholipids by a protein fraction obtained from canine pulmonary lavage.
Surfactant phospholipid exists in multicompartment pools within the subphase of the lung. Movement among these pools and back into type II alveolar cells may be catalyzed by a phospholipid transfer protein resident in the subphase. We demonstrate here that a protein fraction obtained from canine lung lavage catalyzes the intermembrane transfer of all the major surfactant phospholipids. The protein is probably not derived from serum and is unrelated to surfactant proteins that have already been described.
Lumb
R H
RH
Cardiovascular Research Institute, University of California, San Francisco.
Benson
B J
BJ
Clements
J A
JA
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis*; D002850:Chromatography, Gel; D004285:Dogs; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D011663:Pulmonary Surfactants / Q000378:metabolism
D010743:Phospholipids; D011663:Pulmonary Surfactants