First field trial of fox vaccination against rabies using a vaccinia-rabies recombinant virus.
A field trial of fox vaccination against rabies using a vaccinia-rabies recombinant virus was carried out in Belgium on October 24, 1987. Each vaccine capsule contained a suspension of 10(8) TCID50 of the recombinant virus and was introduced into a chicken head. Each chicken head contained 150 mg of tetracycline as a marker of uptake. Two hundred and fifty heads were distributed in an area of 6 km2 situated within a military zone. The bait uptake was monitored for 15 days after the distribution. Sixty-three per cent of the chicken heads were taken by wild animals within that period. The trial was controlled according to the rules defined by the World Health Organisation.
Pastoret
P P
PP
Department of Virology-Immunology, Faculty of Veterinary Medicine, Brussels, Belgium.
Brochier
B
B
Languet
B
B
Thomas
I
I
Paquot
A
A
Bauduin
B
B
Kieny
M P
MP
Lecocq
J P
JP
De Bruyn
J
J
Costy
F
F
D000818:Animals; D001530:Belgium; D005589:Foxes; D006801:Humans; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000008:administration & dosage; D013752:Tetracycline / Q000032:analysis; D013997:Time Factors; D014611:Vaccination / Q000662:veterinary*; D014614:Vaccines, Synthetic / Q000008:administration & dosage; D014616:Vaccinia virus; D014765:Viral Vaccines / Q000008:administration & dosage
D011819:Rabies Vaccines; D014614:Vaccines, Synthetic; D014765:Viral Vaccines; D013752:Tetracycline