Placental transfer of cefoperazone and sulbactam in the isolated in vitro perfused human placenta.
The transfer of cefoperazone and sulbactam across the human placenta was studied qualitatively and quantitatively with the isolated in vitro bidirectionally perfused human placental lobule. Clearance indexes for both cefoperazone and sulbactam were derived. The absence of active transport and facilitated diffusion were documented, implying simple diffusion as the mechanism of placental transfer for both drugs. Placental tissue levels were also studied.
Fortunato
S J
SJ
Department of Obstetrics and Gynecology, University of Texas Health Sciences Center, Southwestern Medical School, Dallas.
Bawdon
R E
RE
Baum
M
M
D001692:Biological Transport; D002438:Cefoperazone / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D010920:Placenta / Q000378:metabolism*; D013407:Sulbactam / Q000493:pharmacokinetics*
D002438:Cefoperazone; D013407:Sulbactam