Elimination kinetics of circulating antigens and immune complexes. I. A simple multicompartment model for the analysis of blood elimination of intravenously injected antigens and immune complexes.
A multi-compartment model designed to analyse the blood elimination kinetics of intravenously injected radiolabelled antigens in experimental animals is presented. The model was fitted to experimental data on blood radioactivity levels at different times following intravenous injection of radiolabelled antigen. Numerical values were obtained for tissue association, degradation, and urinary recovery of degradation products. The model may prove useful as a test for reticuloendothelial function.
Sundqvist
T
T
Department of Medical Microbiology, University of Linköping, Sweden.
Johansson
A
A
Ljunghusen
O
O
Skogh
T
T
D000818:Animals; D000936:Antigen-Antibody Complex / Q000008:administration & dosage* / Q000378:metabolism; D000941:Antigens / Q000008:administration & dosage* / Q000378:metabolism; D004140:Dinitrophenols / Q000008:administration & dosage / Q000097:blood*; D006241:Haptens / Q000008:administration & dosage / Q000378:metabolism; D006400:Hematocrit; D007275:Injections, Intravenous; D008433:Mathematics; D008657:Metabolic Clearance Rate; D051379:Mice; D008807:Mice, Inbred BALB C; D008954:Models, Biological; D012709:Serum Albumin / Q000008:administration & dosage / Q000097:blood*
D000936:Antigen-Antibody Complex; D000941:Antigens; D004140:Dinitrophenols; D006241:Haptens; D012709:Serum Albumin; C058064:dinitrophenyl-human serum albumin conjugate