title: Skeletal muscle ventricles as a potential right heart assist or substitute.
abstract: Skeletal muscle ventricles (SMV) were constructed from canine latissimus dorsi muscle and chronically stimulated to pump fluid within a totally implantable mock circulation device. They were stimulated to contract at either 95/min (N = 7) or 54/min (N = 4). The preload was chronically maintained at 20 mmHg. After 1 month of continuous pumping the SMV were capable of generating a stroke work of 0.134 X 10(6) ergs and power output of 0.021 watts, representing 61% and 42% of the stroke work and power output of the native canine right ventricle, respectively.
authors.affiliation: Harrison Department of Surgical Research, Philadelphia, Pennsylvania.
authors.forename: W A
authors.initials: WA
authors.lastname: Anderson
authors.forename: J S
authors.initials: JS
authors.lastname: Andersen
authors.forename: C R
authors.initials: CR
authors.lastname: Bridges
authors.forename: R L
authors.initials: RL
authors.lastname: Hammond
authors.forename: F
authors.initials: F
authors.lastname: DiMeo
authors.forename: E E
authors.initials: EE
authors.lastname: Frisch
authors.forename: S
authors.initials: S
authors.lastname: Salmons
authors.forename: L W
authors.initials: LW
authors.lastname: Stephenson
mesh_terms: D000818:Animals; D001243:Assisted Circulation; D002302:Cardiac Output; D003326:Coronary Circulation; D004285:Dogs; D004868:Equipment Failure; D006353:Heart-Assist Devices; D009132:Muscles / Q000637:transplantation*; D011183:Postoperative Complications / Q000209:etiology; D013318:Stroke Volume