[Index of the proliferative activity of a cell culture in assessing the cytotoxicity of antiviral chemical preparations].
The influence of cytotoxicity of a number of antiviral compounds on the cell culture functional activity was studied by evaluating the changes in the kinetic cell growth parameters. Significant differences between the values of cytotoxicity were found with ribamide in cell lines of different origins. The differences in the measured values of cytotoxicity of the four antiviral compounds under study were demonstrated using the proposed proliferation cytotoxicity criterion (PCT).
Lymar'
V T
VT
Pshenichnov
A V
AV
D000212:Acyclovir / Q000633:toxicity; D000818:Animals; D000998:Antiviral Agents / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D012254:Ribavirin / Q000633:toxicity; D012299:Rimantadine / Q000633:toxicity
D000998:Antiviral Agents; D012299:Rimantadine; D012254:Ribavirin; D000212:Acyclovir
Pokazatel' proliferativnoĭ aktivnosti kul'tury kletok v otsenke tsitotoksichnosti protivovirusnykh khimiopreparatov.