Vaginal abnormalities in ovariectomized BALB/cCrgl mice after neonatal exposure to different doses of diethylstilbestrol.
Newborn BALB/cCrgl female mice received five daily injections of various doses of diethylstilbestrol (DES), 0.0001-10 micrograms. Mice were killed at 6 days of age or at 4 months after ovariectomy at 40-42 days. Subepithelial nodules of polygonal cells in the upper (Mullerian) vagina during early postnatal life were associated with the later occurrence of ovary-independent persistent stratification with or without cornification in mice treated neonatally with 0.1-10 micrograms DES and thus are a possible predictor of this phenomenon. The thresholds for the induction of ovary-independent epithelial pegs, downgrowths and adenosis (glandular formations) were 0.1 microgram and 0.5 microgram DES/day, respectively.
Iguchi
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Department of Zoology, University of California, Berkeley 94720.
Ostrander
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PL
Mills
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Bern
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HA
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D004054:Diethylstilbestrol / Q000008:administration & dosage / Q000633:toxicity*; D004848:Epithelium / Q000473:pathology; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010052:Ovariectomy; D014621:Vagina / Q000187:drug effects* / Q000254:growth & development / Q000473:pathology
D004054:Diethylstilbestrol