Effect of suxamethonium given during recovery from atracurium.
Suxamethonium was given in varying doses when twitch response had returned to 50% of control following the administration of atracurium in anaesthetized patients. Small doses of suxamethonium produced antagonism, enhancement of the block, or a combination showing a biphasic response. A dose of 3 mg kg-1 was needed to produce consistently 100% block of the twitch. The subsequent recovery rate for T1 was as fast as that seen normally after suxamethonium and was not enhanced by neostigmine.
Scott
R P
RP
Shackleton Department of Anaesthetics, University Hospital, Southampton.
Norman
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001279:Atracurium / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009388:Neostigmine / Q000494:pharmacology; D013390:Succinylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D001279:Atracurium; D009388:Neostigmine; D013390:Succinylcholine