Changes in amine oxidase in plasma of rats treated with hepatotoxins.
When allyl formate (AF) was administered to rats, the marked elevation of B-form MAO activity in plasma was found with beta-PEA as a substrate. In contrast, in the case of carbon tetrachloride (CCl4), A-form MAO activity elevated predominantly. The deaminations of 5-HT and beta-PEA in these plasma treated with AF or CCl4 were not inhibited completely by a high concentration of MAO inhibitor, deprenyl or clorgyline. These results indicate that there may be two or more distinct amine oxidases released from the liver and other organs in response to CCl4 or AF.
Obata
T
T
Department of Pharmacology, Medical College of Oita, Japan.
Egashira
T
T
Yamanaka
Y
Y
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D005260:Female; D005561:Formates / Q000633:toxicity*; D005563:Formic Acid Esters / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood* / Q000378:metabolism; D010627:Phenethylamines; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin; D013379:Substrate Specificity
D005561:Formates; D005563:Formic Acid Esters; D010627:Phenethylamines; C029261:phenethylamine; D012701:Serotonin; C034499:allyl formate; D002251:Carbon Tetrachloride; D008995:Monoamine Oxidase