Fatty acid effects on gluconeogenesis in goat, calf and guinea pig hepatocytes.
1. Regulation of hepatic gluconeogenesis by fatty acid was studied in goat, calf and guinea pig hepatocytes. 2. Fatty acid effects on gluconeogenesis were dependent upon species; fatty acid and gluconeogenic substrate. 3. Oleate and octanoate inhibited gluconeogenesis from propionate in guinea pig hepatocytes and stimulated it in goat hepatocytes. 4. Oleate and octanoate markedly inhibited gluconeogenesis from lactate in guinea pig hepatocytes whereas octanoate, but not oleate, decreased glucose production from lactate in goat hepatocytes. 5. Effects of fatty acids on gluconeogenesis in calf hepatocytes were similar to goat hepatocytes suggesting control of gluconeogenesis is similar among ruminant species but differs from guinea pigs.
Aiello
R J
RJ
Department of Dairy Science, University of Wisconsin, Madison 53706.
Armentano
L E
LE
D000818:Animals; D002210:Caprylates / Q000494:pharmacology; D002417:Cattle; D005227:Fatty Acids / Q000494:pharmacology*; D005260:Female; D005943:Gluconeogenesis / Q000187:drug effects*; D006041:Goats; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000494:pharmacology; D013045:Species Specificity
D002210:Caprylates; D005227:Fatty Acids; D009829:Oleic Acids; D019301:Oleic Acid; C031492:octanoic acid