Age-related changes of heat shock protein gene transcription in human peripheral blood mononuclear cells.
In this study, we show the age-related retardation of heat shock 70 kD protein (hsp 70) gene transcription in peripheral blood mononuclear cells (PBMC). The amount of maximum transcription of the hsp 70 gene is decreased in PBMC from aged subjects, compared with PBMC from young control subjects. It might mean that the ability for homeostasis against heat shock stress decreases in PBMC from aged subjects. Our observation might be at least correlative and consistent with the age-related change of a possible essential function in PBMC.
Deguchi
Y
Y
Third Department of Internal Medicine, Osaka University School of Medicine, Japan.
Negoro
S
S
Kishimoto
S
S
D000199:Actins / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002467:Cell Nucleus / Q000502:physiology; D005786:Gene Expression Regulation; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000502:physiology*; D014158:Transcription, Genetic
D000199:Actins; D006360:Heat-Shock Proteins