[Use of biological methods in the analysis of the purinergic activity of etimizol].
To analyse etimizol purinergic activity, methods of biological analysis were applied using isolated smooth muscle strips of the guinea-pig caecum and developing embryo cultures of the sea urchin (Strongylocentrotus intermedius). Stimulating etimizol action in 10(-8)-10(-12) M concentration was observed on embryonal development in the sea urchin to be eliminated by co-action of etimizol and P1-purinoceptor antagonist theophylline. The analogous action of the preparations was established using isolated smooth muscle strips of the guinea-pig caecum.
Migas
E A
EA
Zavodskaia
I S
IS
Kachalov
Iu P
IuP
Chernysheva
O N
ON
D000818:Animals; D001681:Biological Assay; D002432:Cecum; D004622:Embryo, Mammalian / Q000187:drug effects; D004625:Embryo, Nonmammalian; D005042:Etimizol / Q000494:pharmacology*; D006168:Guinea Pigs; D007093:Imidazoles / Q000494:pharmacology*; D009130:Muscle, Smooth / Q000187:drug effects*; D011983:Receptors, Purinergic / Q000187:drug effects*; D012617:Sea Urchins / Q000196:embryology; D013806:Theophylline / Q000494:pharmacology
D007093:Imidazoles; D011983:Receptors, Purinergic; D013806:Theophylline; D005042:Etimizol
Ispol'zovanie biologicheskikh metodov dlia analiza purinergicheskoĭ aktivnosti étimizola.