title: Conformational changes in the IgG molecule of lepromatous sera using laser Raman spectroscopy.
abstract: In the present work we report our studies on IgG separated from the serum of lepromatous patients and non-lepromatous leprosy cases using Laser Raman Spectroscopy. Striking spectral changes in LL cases have been observed in the following special regions: (a) the amide I and III, (b) the S-S and C-S stretching (c) the skeletal bending and (d) skeletal stretching regions. These changes indicate a decrease in the amount of beta-structure and a transition towards alpha-helical conformation.
authors.affiliation: Dept. of Physics and Astrophysics, University of Delhi.
authors.forename: R
authors.initials: R
authors.lastname: Kumar
authors.forename: M M
authors.initials: MM
authors.lastname: Bajaj
authors.forename: B
authors.initials: B
authors.lastname: Swaroop
mesh_terms: D004268:DNA-Binding Proteins / Q000097:blood; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007834:Lasers; D015440:Leprosy, Lepromatous / Q000097:blood*; D013058:Mass Spectrometry; D011487:Protein Conformation; D013237:Stereoisomerism
chemical_list: D004268:DNA-Binding Proteins; D007074:Immunoglobulin G