Collagen degradation by experimentally-induced subcutaneous granulation tissue in the rat.
Granulation tissue provoked by implantation of cellulose sponge or a nylon bag degraded a powder of homologous collagen. This activity was located in a non-filtrable tissue fraction and was associated with the appearance of mononuclear and histiocytic giant cells, following an early polymorphonuclear-cell infiltration. The activity could be manipulated experimentally, indicating that this model can be used in investigations of inflammation-induced collagen degradation.
Asman
B
B
Department of Periodontology, Karolinska Institute, Huddinge University Hospital, Sweden.
Ekberg
O
O
Hjerpe
A
A
D000818:Animals; D003094:Collagen / Q000378:metabolism*; D004195:Disease Models, Animal; D006097:Granulation Tissue / Q000378:metabolism* / Q000473:pathology; D007249:Inflammation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003094:Collagen