[Protective activity of preparations of blood plasma from donors with a high titer of natural antibodies to Re-glycolipid of gram-negative bacteria].
The screening of the preparations of blood plasma obtained from 1,608 donors made it possible to establish the presence of high titers of natural antibodies to Re-glycolipid in 3% of the donors. Donor plasma containing antibodies to Re-glycolipid in a titer of 1:128 ensured a high level of protection for mice in experimental fecal peritonitis. The treatment of 10 patients having commonly occurring forms of peritonitis, caused by Gram-negative bacteria, with the use of such plasma yielded a positive clinical effect. The presence of correlation between the titers of antibodies to Re-glycolipid in blood plasma preparations and the content of high-density lipoproteids, expressed in per cent, was noted.
Rudik
A A
AA
Kropacheva
E I
EI
Apollonin
A V
AV
Sevast'ianova
E K
EK
Likhoded
V G
VG
D000293:Adolescent; D000328:Adult; D000818:Animals; D000906:Antibodies / Q000302:isolation & purification*; D001782:Blood Donors; D005260:Female; D006017:Glycolipids / Q000276:immunology*; D006090:Gram-Negative Bacteria / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D010949:Plasma / Q000276:immunology*; D014774:Virulence
D000906:Antibodies; D006017:Glycolipids; C055264:Re-glycolipid
Protektivnaia aktivnost' preparatov plazmy krovi donorov s vysokim titrom estestvennykh antitel k Re-glikolipidu gramotritsatel'nykh bakteriĭ.