title: Treatment of neonatal necrotizing tracheobronchitis with extracorporeal membrane oxygenation and bronchoscopy.
abstract: Necrotizing tracheobronchitis has recently been described as a complication of mechanical ventilation of newborns with respiratory failure. Despite the use of bronchoscopy, 45% of the reported patients to date have died. In this study, we report the use of extracorporeal membrane oxygenation (ECMO) to stabilize two patients with necrotizing tracheobronchitis. While supported by bypass, both patients underwent prolonged bronchoscopies with removal of extensive amounts of tracheal debris. ECMO provided efficient oxygenation in the face of near total airway occlusion, and permitted far more extensive bronchoscopic debridement and lavage than would have been possible if the lungs were required for oxygenation. In addition, ECMO provided a period of lung "rest" during which ventilator settings were reduced, thus minimizing further barotrauma and allowing for lung and airway healing. Both patients recovered without significant respiratory sequelae. ECMO and bronchoscopy are effective forms of therapy for patients with life-threatening necrotizing tracheobronchitis when conventional modalities of treatment have failed.
authors.affiliation: Department of Pediatrics, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.
authors.forename: E J
authors.initials: EJ
authors.lastname: Michael
authors.forename: D
authors.initials: D
authors.lastname: Zwillenberg
authors.forename: A
authors.initials: A
authors.lastname: Furnari
authors.forename: L
authors.initials: L
authors.lastname: Sheppard
authors.forename: H J
authors.initials: HJ
authors.lastname: Desai
authors.forename: P J
authors.initials: PJ
authors.lastname: Wolfson
authors.forename: N B
authors.initials: NB
authors.lastname: Robinson
authors.forename: M
authors.initials: M
authors.lastname: Kornhauser
authors.forename: S
authors.initials: S
authors.lastname: Mobley
authors.forename: P A
authors.initials: PA
authors.lastname: Branca
mesh_terms: D001991:Bronchitis / Q000473:pathology / Q000628:therapy*; D001999:Bronchoscopy; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009336:Necrosis; D014136:Tracheitis / Q000473:pathology / Q000628:therapy*