Effect of iodinated contrast media on the phagocytic activity of human leukocytes. A new toxicity test.
The effect of radiographic contrast media on zymosan-induced phagocytic activity of human blood samples was studied with an automatic luminometer. At iodine concentration of 0.2% biliary contrast media almost totally inhibited leukocyte phagocytosis. The effects of iohexol and iopamidol were nearly identical, eg, negligible inhibition at 0.05% and about 65% inhibition at 1%. Metrizamide, iodixanol, and iopentol cause no or little inhibition at concentrations 0.05% and 0.2% and about 50% inhibition at the concentration of 1% iodine. Among ionic contrast media, sodium salts inhibited leukocyte phagocytosis in vitro less than methylglucamine salts. Because the chemiluminometric method is rapid and easily reproducible even in large series, it may be useful in toxicity surveys of potential contrast media.
Halkola
H
H
Department of Diagnostic Radiology, University Central Hospital, Turku, Finland.
Kormano
M
M
D003287:Contrast Media / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects*; D008163:Luminescent Measurements; D010587:Phagocytosis / Q000187:drug effects*
D003287:Contrast Media