title: Regression of oral hairy leukoplakia during zidovudine therapy.
abstract: We describe two patients with human immunodeficiency virus infection and oral hairy leukoplakia whose tongue lesions resolved on oral zidovudine therapy. During therapy, each patient had a measurable reduction in human immunodeficiency virus antigen corresponding with clinical regression of oral lesions. The clinical course suggests that zidovudine may have contributed to the resolution of these lesions either indirectly through immunologic improvement or through an antiviral effect.
authors.affiliation: Department of Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612.
authors.forename: H A
authors.initials: HA
authors.lastname: Kessler
authors.forename: C A
authors.initials: CA
authors.lastname: Benson
authors.forename: P
authors.initials: P
authors.lastname: Urbanski
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D006801:Humans; D007972:Leukoplakia, Oral / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014062:Tongue Neoplasms / Q000150:complications / Q000188:drug therapy*; D014064:Tongue, Hairy / Q000150:complications / Q000188:drug therapy; D015215:Zidovudine / Q000627:therapeutic use*
chemical_list: D015215:Zidovudine