Correcting for the bias caused by drop-outs in hypertension trials.
A major source of bias in hypertension trials can arise from patients who are withdrawn during the course of the trial because of inadequate blood pressure control. We develop a mechanism which allows for such withdrawals while preserving the potential to make an unbiased comparison of the treatment effects. The approach is illustrated using data from a large multicentre trial of two anti-hypertensive agents in patients with mild to moderate essential hypertension.
Murray
G D
GD
University Department of Surgery, Western Infirmary, Glasgow, Scotland.
Findlay
J G
JG
D002986:Clinical Trials as Topic / Q000379:methods*; D003627:Data Interpretation, Statistical; D004311:Double-Blind Method; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007650:Ketanserin / Q000627:therapeutic use; D008790:Metoprolol / Q000627:therapeutic use; D010352:Patient Dropouts; D011897:Random Allocation
D007650:Ketanserin; D008790:Metoprolol