[Risks of premedication with benzodiazepines exemplified by a case of asphyxia caused by flunitrazepam].
Oral premedication with benzodiazepines is well established in clinical anaesthesia. Appreciation of the specific pharmacodynamic profile of available drugs suggest individual prescription for certain groups of patients. We report a case of severe respiratory depression following oral premedication with flunitrazepam 1 mg in a patient with intracranial neoplasma. With respect to this complication and a review of the literature we suggest administration of short acting benzodiazepines with pronounced anxiolytic and moderate sedative properties (lormetazepam type) for neurosurgical patients.
Schäfer
M
M
Klinik für Anästhesiologie der Johannes Gutenberg-Universität Mainz.
Jantzen
J P
JP
Wallenfang
T
T
D001237:Asphyxia / Q000139:chemically induced*; D001932:Brain Neoplasms / Q000150:complications / Q000601:surgery*; D005445:Flunitrazepam / Q000009:adverse effects*; D005625:Frontal Lobe / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000601:surgery; D011229:Preanesthetic Medication / Q000009:adverse effects*; D012131:Respiratory Insufficiency / Q000139:chemically induced; D012307:Risk Factors
D005445:Flunitrazepam
Risiken der Prämedikation mit Benzodiazepinen am Beispiel einer Asphyxie nach Flunitrazepam.