title: Reproducibility of heart rate changes following adenosine infusion in man.
abstract: The change in heart rate following infusion of adenosine in healthy human subjects was studied on two occasions. Adenosine produced a significant, dose-related increase in heart rate. Tachyphylaxis to this effect of the naturally occurring nucleoside did not occur. There was a tendency for prolonged infusion to cause a greater increase in heart rate, but this did not reach significance.
authors.affiliation: Department of Clinical Pharmacology, Cardiothoracic Institute, Brompton Hospital, London, UK.
authors.forename: B
authors.initials: B
authors.lastname: Clarke
authors.forename: T B
authors.initials: TB
authors.lastname: Conradson
authors.forename: C M
authors.initials: CM
authors.lastname: Dixon
authors.forename: P J
authors.initials: PJ
authors.lastname: Barnes
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D013618:Tachyphylaxis
chemical_list: D000241:Adenosine