Intravital-microscopic observations on the intravascular behavior of blood cell components during dietary-induced hyperlipidemia in the male rabbit.
In normal male rabbits loaded dietary cholesterol, intravital-microscopy revealed a marked acceleration of intravascular adhesiveness of white blood cells and aggregability of red blood cells and a swarming of lipid-laden macrophages in connective tissue space concurrently with a systemic hyperlipidemia and anemia. Possible roles of the microcirculatory changes in the atherogenesis were discussed.
Asano
M
M
Department of Physiological Hygiene, Institute of Public Health, Tokyo, Japan.
Ohkubo
C
C
Hirokawa
A
A
Sasaki
A
A
Tochihara
Y
Y
Chiba
Y
Y
D000818:Animals; D001773:Blood Cells / Q000473:pathology / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary; D006949:Hyperlipidemias / Q000097:blood* / Q000209:etiology; D008055:Lipids / Q000097:blood; D008297:Male; D008833:Microcirculation; D003668:Pressure Ulcer / Q000097:blood / Q000209:etiology; D011817:Rabbits
D002791:Cholesterol, Dietary; D008055:Lipids; D002784:Cholesterol