Axotomy induces MHC class I antigen expression on rat nerve cells.
Immunomorphological staining demonstrates that class I major histocompatibility complex (MHC)-coded antigen expression can be selectively induced on otherwise class I-negative rat nerve cells by peripheral axotomy. Induction of class I as well as class II antigen expression was simultaneously seen on non-neural cells in the immediate vicinity of the injured nerve cells. As nerve regeneration after axotomy includes growth of new nerve cell processes and formation of new nerve cell contacts, the present findings raise the question of a role for MHC-coded molecules in cell-cell interactions during nerve cell growth.
Maehlen
J
J
Department of Pathology (Neuropathology), Huddinge Hospital, Karolinska Institute, Stockholm, Sweden.
Schröder
H D
HD
Klareskog
L
L
Olsson
T
T
Kristensson
K
K
D000818:Animals; D000911:Antibodies, Monoclonal; D001933:Brain Stem / Q000276:immunology / Q000502:physiology; D005154:Facial Nerve; D005786:Gene Expression Regulation; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D009046:Motor Neurons / Q000276:immunology* / Q000502:physiology; D009416:Nerve Regeneration; D010525:Peripheral Nerves / Q000276:immunology* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve; D013116:Spinal Cord / Q000276:immunology / Q000502:physiology
D000911:Antibodies, Monoclonal; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II