title: Formation of DNA adduct 8-hydroxy-2'-deoxyguanosine induced by man-made mineral fibres.
abstract: Two man-made mineral fibres, rockwool and glasswool, were found to mediate hydroxylation of deoxyguanosine and calf thymus DNA to form the DNA adduct 8-hydroxy-2'-deoxyguanosine. The modification of the nucleoside is probably mediated by hydroxyl radicals and may play a role in fibre-induced carcinogenesis.
authors.affiliation: Department of Occupational Medicine, Faculty of Health Sciences, Linköping, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Leanderson
authors.forename: P
authors.initials: P
authors.lastname: Söderkvist
authors.forename: C
authors.initials: C
authors.lastname: Tagesson
authors.forename: O
authors.initials: O
authors.lastname: Axelson
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA / Q000378:metabolism*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000378:metabolism; D005898:Glass / Q000633:toxicity*; D008903:Minerals / Q000633:toxicity*; D010084:Oxidation-Reduction
chemical_list: D008903:Minerals; C009753:fiberglass; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D003849:Deoxyguanosine