Penetration of nadolol into aqueous humour after a single oral dose.
Nadolol 20 mg was administered orally as a single-blind, single dose to nine patients about to undergo cataract extraction. Intraocular pressures fell by a mean of 24% 3 h after administration. During the operation, aqueous humour and serum samples were taken for measurement of nadolol concentrations. Aqueous nadolol concentrations ranged from 3.8 to 13.4 ng ml-1, and correlated with the serum drug concentrations (r = 0.84). The fall in intraocular pressure did not correlate with either the aqueous humour or plasma concentrations of nadolol.
Tiong
T H
TH
Warrington District Hospital.
Hung
S O
SO
Perelman
M S
MS
D000284:Administration, Oral; D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009248:Nadolol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011674:Pulse / Q000187:drug effects
D009248:Nadolol