Selective activation of striatal output nuclei by organophosphorus intoxication in the rat: EEG and 2-deoxy[3H]glucose metabolic mapping.
Central effects of paraoxon (an organophosphate, inhibitor of acetylcholinesterase) treatment were investigated using 2-deoxyglucose (2-DG) and EEG methods. Six rat brain structures (external globus pallidus, ventral anterior nucleus of thalamus, entopeduncular nucleus, substantia nigra pars reticulata and superior colliculus) presented an increase of 2-DG labelling after acute injection of this toxic compound. The EEG recordings showed hippocampal slow theta rhythm which preceded an increase of cortical rhythm frequency. Rats with 2-DG mapping modifications presented also EEG seizures.
Pellet-Gondret
M H
MH
Laboratoire de Neurophysiologie Ontogénétique, Université Pierre et Marie Curie, Paris, France.
Mailly
P
P
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001931:Brain Mapping / Q000379:methods; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D004569:Electroencephalography; D010261:Paraoxon / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced; D014316:Tritium
D002800:Cholinesterase Inhibitors; D003837:Deoxy Sugars; D014316:Tritium; D003847:Deoxyglucose; D010261:Paraoxon