The Emory mouse cataract: the effects on cataractogenesis of alpha-tocopherol, penicillamine, triethylenetetramine, and mercaptopropionylglycine.
The Emory mouse develops a late-onset hereditary cataract bearing some resemblances to human senile cataract. It was used as a model system for testing the effects of several drugs expected to have anticataractogenic potential. A low level of added dietary alpha-tocopherol had only a marginal effect. Penicillamine increased lens soluble protein, a good index of lens viability. Triethylenetetramine was too toxic to permit satisfactory treatment. Mercaptopropionylglycine produced several positive effects including a retardation of cataract at 6 months of age; parameters which increased under drug treatment were lens weight, soluble protein content and protein sulfhydryl, but not glutathione. There was no effect on the total calcium concentration.
Kuck
J F
JF
Department of Ophthalmology, Emory University, Atlanta, Georgia.
Kuck
K D
KD
D000818:Animals; D002386:Cataract / Q000178:diet therapy / Q000188:drug therapy*; D005029:Ethylenediamines / Q000627:therapeutic use*; D051379:Mice; D008815:Mice, Inbred Strains; D010396:Penicillamine / Q000627:therapeutic use*; D008625:Tiopronin / Q000627:therapeutic use*; D014266:Trientine / Q000627:therapeutic use*; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*
D005029:Ethylenediamines; D014810:Vitamin E; D008625:Tiopronin; D010396:Penicillamine; D014266:Trientine