title: Urinary Charcot-Leyden crystals in the hypereosinophilic syndrome with acute renal failure.
abstract: A 48-year-old man with idiopathic hypereosinophilic syndrome (IHS) developed blast crisis along with a fulminant autoimmune hemolytic anemia. Hemoglobinuria and anuric acute renal failure (ARF) ensued. Urinalysis revealed countless Charcot-Leyden crysals (CLC). This is the only known report of Charcot-Leyden crystalluria. The CLC protein (lysophospholipase) should normally undergo glomerular filtration and catabolism by the tubules during reabsorption. Its abundant presence in the urine of our patient may reflect impairment of tubular reabsorption, saturation of the tubular reabsorptive process by excessive CLC load through residual functioning glomeruli, or a combination thereof. The extreme degree of hypereosinophilia suggests a massive load of CLC protein and acute tubular necrosis implies impaired tubular function, so both mechanisms should have been operative. At the autopsy, no eosinophilic infiltrates were present in the kidneys, which points against a local spillage of CLC protein into the tubules.
authors.affiliation: Department of Pathology, Naval Hospital, Bethesda, MD.
authors.forename: P
authors.initials: P
authors.lastname: Hirszel
authors.forename: A W
authors.initials: AW
authors.lastname: Cashell
authors.forename: T V
authors.initials: TV
authors.lastname: Whelan
authors.forename: R
authors.initials: R
authors.lastname: Dolan
authors.forename: A
authors.initials: A
authors.lastname: Yoshihashi
mesh_terms: D058186:Acute Kidney Injury / Q000652:urine*; D000744:Anemia, Hemolytic, Autoimmune / Q000652:urine; D003460:Crystallization; D004802:Eosinophilia / Q000652:urine*; D006023:Glycoproteins / Q000652:urine*; D006801:Humans; D008245:Lysophospholipase; D008297:Male; D008875:Middle Aged; D013577:Syndrome
chemical_list: D006023:Glycoproteins; D008245:Lysophospholipase; C011711:lysolecithin acylhydrolase