Stimulated esophageal groove closure in adult goats.
In healthy adult goats, closure of the esophageal groove was induced by thirst, IV administered vasopressin, and intracarotid administration of hypertonic NaCl solutions. The efficiency of stimulation was tested directly by visual inspection of the course taken by orally administered solutions through a ruminal or abomasal fistula, palpation of the lips of the esophageal groove through a ruminal fistula, and indirectly by following the glucose dynamics in the blood after oral administration of glucose solution. Esophageal groove closure was observed during drinking after a 48-hour period of water deprivation. Intracarotid administration of 1.5 ml of a saturated solution or 10.5 ml of a 1.5% solution of NaCl also stimulated groove closure; however, groove closure stimulated by administration of vasopressin is the most satisfactory procedure for passing compounds of therapeutic importance directly from the cardiac orifice to the abomasum.
Mikhail
M
M
Department of Physiology and Therapeutic Pharmacodynamics, Ecole Nationale Vétérinarie d'Alfort, Maisuns-Alfort, France.
Brugère
H
H
Le Bars
H
H
Colvin
H W
HW
D000018:Abomasum / Q000502:physiology; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004947:Esophagus / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006041:Goats / Q000502:physiology*; D008297:Male; D012044:Regression Analysis; D012965:Sodium Chloride / Q000494:pharmacology; D013894:Thirst / Q000502:physiology*; D014667:Vasopressins / Q000494:pharmacology; D014868:Water Deprivation
D001786:Blood Glucose; D014667:Vasopressins; D012965:Sodium Chloride; D005947:Glucose