title: Treatment of hypercalcaemia in thyrotoxicosis with aminohydroxypropylidene diphosphonate.
abstract: Two patients had symptomatic hypercalcaemia accompanying thyrotoxicosis, despite initial treatment with volume repletion, beta blockade and antithyroid drugs. They were further managed with intravenous infusions of aminohydroxypropylidene diphosphonate resulting in rapid normalization of the serum calcium, with relief of symptoms. Aminohydroxypropylidene diphosphonate effectively suppressed the increased bone resorption of thyrotoxicosis without any undesirable adverse effects.
authors.affiliation: University Department of Medicine, Royal Infirmary, Glasgow, UK.
authors.forename: T T
authors.initials: TT
authors.lastname: Tan
authors.forename: A A
authors.initials: AA
authors.lastname: Alzaid
authors.forename: N
authors.initials: N
authors.lastname: Sutcliffe
authors.forename: M D
authors.initials: MD
authors.lastname: Gardner
authors.forename: J A
authors.initials: JA
authors.lastname: Thomson
authors.forename: I T
authors.initials: IT
authors.lastname: Boyle
mesh_terms: D000328:Adult; D004164:Diphosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy* / Q000209:etiology; D007262:Infusions, Intravenous; D008297:Male; D000077268:Pamidronate; D013971:Thyrotoxicosis / Q000150:complications*
chemical_list: D004164:Diphosphonates; D000077268:Pamidronate