[Structural changes in the neuropil of the frontal cortex in schizophrenia].
Samples of the prefrontal cortex neuropile autopsied from schizophrenic patients were subjected to electron microscopy. Dystrophic changes were found in the dendrites: pronounced swelling with microtubuli reduced in number or totally absent and mitochondria swollen. Synaptic changes were generally of a functional nature but presynaptic endings were found degenerating with a dense type. Myelinated fibers of various diameters showed pathologic changes. These findings are seen as a structural background for integrative and informative processes deterioration in the prefrontal cortex of schizophrenic patients.
Uranova
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D000328:Adult; D000368:Aged; D001369:Axons / Q000648:ultrastructure; D003712:Dendrites / Q000648:ultrastructure; D005625:Frontal Lobe / Q000648:ultrastructure*; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure; D009457:Neuroglia / Q000648:ultrastructure*; D009474:Neurons / Q000648:ultrastructure*; D012559:Schizophrenia / Q000473:pathology*; D012563:Schizophrenia, Paranoid / Q000473:pathology; D013569:Synapses / Q000648:ultrastructure
Strukturnye izmeneniia neĭropilia lobnoĭ kory pri shizofrenii.