[Cerebrovascular ischemic accident and congenital protein C deficiency in children: apropos of a case].
The authors report the case of a 15-month-old boy with left hemiparesia related to a right sylvian ischemic incident, confirmed by CT scan and carotid angiography. Long-term evolution was favourable with anti-aggregant platelet treatment. A large constitutional protein C deficiency (40%) proved to be the etiology. Protein C is a powerful, physiological, vitamin K-dependent anti-coagulant which neutralizes activated factors V and VIII. Congenital protein C deficiency is responsible for recurrent spontaneous thrombosis affecting the young, mainly in the venous areas, since arterial incidents are less frequent. Protein C assays should be included in the systematic etiologic check-up for thrombotic incidents in children.
Chateil
F
F
Service de pédiatrie, hôpital des Enfants, Bordeaux, France.
Baronnet
R
R
Guérin
V
V
Fontan
D
D
Guillard
J M
JM
D002545:Brain Ischemia / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D007223:Infant; D011486:Protein C / Q000502:physiology; D020151:Protein C Deficiency
D011486:Protein C
Accident vasculaire cérébral ischémique de l'enfant et déficit congénital en protéine C: à propos d'une observation.