title: [Intrarectal clonazepam in children. Plasma and CSF levels].
abstract: Eleven children with seizures were treated with clonazepam by rectal route. Thirty minutes after the administration, the plasma (8 to 28 ng/ml) and CSF (0.9 to 2.26 ng/ml) levels were satisfactory and correlated with a good clinical result. Since the tolerance of the drug was excellent, clonazepam appears to be as useful as diazepam in the management of childhood seizures.
authors.affiliation: Service de pédiatrie, néonatologie, Centre Hospitalier de Tarbes, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Netter
authors.forename: M
authors.initials: M
authors.lastname: Fornaris
authors.forename: G
authors.initials: G
authors.lastname: Bildstein
authors.forename: R
authors.initials: R
authors.lastname: Chateauneuf
authors.forename: J P
authors.initials: JP
authors.lastname: Cano
authors.forename: M
authors.initials: M
authors.lastname: Petrus
mesh_terms: D000285:Administration, Rectal; D002648:Child; D002675:Child, Preschool; D002998:Clonazepam / Q000008:administration & dosage* / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012640:Seizures / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy*
chemical_list: D002998:Clonazepam
vernacular_title: Clonazépam intrarectal chez l'enfant. Taux plasmatique et dans le LCR.