Growth hormone-albumin conjugates. Reduced renal toxicity and altered plasma clearance.
The effective therapeutic use of many small peptides such as growth hormone has been limited by their small molecular masses and rapid clearance by the kidneys. Moreover, various degrees of nephrotoxicity have been reported for small proteins which are readily filtered at the level of the glomerulus. We have attempted to circumvent this drawback by conjugating growth hormone (somatotropin) to serum albumin in an effort to alter the peptide's pharmacokinetics while retaining its biological activity.
Poznansky
M J
MJ
Department of Physiology, University of Alberta, Edmonton, Canada.
Halford
J
J
Taylor
D
D
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001806:Blood Urea Nitrogen; D013006:Growth Hormone / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012709:Serum Albumin / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000633:toxicity; D013552:Swine; D014018:Tissue Distribution
D012709:Serum Albumin; D013006:Growth Hormone