title: Skin penetration of CoQ10 in the rat.
abstract: Skin penetration of coenzyme Q10 (CoQ10) was investigated after topical treatment in the rat. The drug was suspended in olive oil and administered at two different concentrations. Coenzyme levels were found to be directly related to the concentrations employed and the contact time. CoQ10 topical treatment might therefore be proposed as a good pharmacological tool in dermatology and cosmetology.
authors.affiliation: Institute of Pharmacology, School of Medicine, University of Pisa, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Giovannini
authors.forename: A A
authors.initials: AA
authors.lastname: Bertelli
authors.forename: V
authors.initials: V
authors.lastname: Scalori
authors.forename: L
authors.initials: L
authors.lastname: Dell'Osso
authors.forename: M G
authors.initials: MG
authors.lastname: Alessandrì
authors.forename: M
authors.initials: M
authors.lastname: Mian
mesh_terms: D000042:Absorption; D000287:Administration, Topical; D000818:Animals; D003067:Coenzymes; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000378:metabolism*; D013997:Time Factors; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10