Analogs of tetrahydrofolate directed at folate-dependent purine biosynthetic enzymes. Characteristics of mediated entry and transport-related resistance in L1210 cells for 5,10-dideazatetrahydrofolate and two 10-alkyl derivatives.
Sirotnak
F M
FM
Memorial Sloan-Kettering, Cancer Center, New York, NY 10021.
Otter
G M
GM
Piper
J R
JR
DeGraw
J I
JI
D000478:Alkylation; D000818:Animals; D001692:Biological Transport; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000502:physiology; D004351:Drug Resistance; D007939:Leukemia L1210; D008727:Methotrexate / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013763:Tetrahydrofolates / Q000378:metabolism* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D013763:Tetrahydrofolates; C045894:lometrexol; D008727:Methotrexate