title: Mitochondrial myopathy in rats fed with a diet containing beta-guanidine propionic acid, an inhibitor of creatine entry in muscle cells.
abstract: In rats with phosphoryl-creatine depletion (fed a standard Randoin-Causeret diet containing 1% beta-guanidine propionic acid) abnormal mitochondria were observed in slow skeletal muscles, often containing paracrystalline inclusions very like those induced by ischaemia or mitochondrial poisons and in human mitochondrial myopathy.
authors.affiliation: Istituto di Patologia Generale, II Cattedra, Pisa, Italy.
authors.forename: Z
authors.initials: Z
authors.lastname: Gori
authors.forename: V
authors.initials: V
authors.lastname: De Tata
authors.forename: M
authors.initials: M
authors.lastname: Pollera
authors.forename: E
authors.initials: E
authors.lastname: Bergamini
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003401:Creatine / Q000378:metabolism; D006146:Guanidines / Q000633:toxicity*; D008297:Male; D008854:Microscopy, Electron; D008931:Mitochondria, Muscle / Q000187:drug effects* / Q000648:ultrastructure; D009132:Muscles / Q000378:metabolism / Q000648:ultrastructure; D009135:Muscular Diseases / Q000139:chemically induced; D010725:Phosphocreatine / Q000378:metabolism; D011422:Propionates / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D006146:Guanidines; D011422:Propionates; D010725:Phosphocreatine; D003401:Creatine; C005775:guanidinopropionic acid