[Medical changes in preformed host arteries involved in a tumor--a morphometric study of gastric, colonic, and pancreatic carcinomas in man].
We found that the performed host arteries left in the tissue of a cancer are subject to marked atrophy and the loss of medial smooth muscles, at least in the gastric, colonic, and pancreatic carcinomas that we have studied in man. Morphometry of the arterial wall tissue in surgical and autopsy material from 30 patients has revealed that the volume ratio of muscle cells dwindles toward and into a tumor from its exterior. This was considered to be responsible for causing characteristic behavior evidence in a cancer such as the abnormal profiles of arteries found on angiography or in their poor response to vasoactive drugs. These medial changes were most remarkable in scirrhous tumors.
Yaegashi
H
H
Dept. of Pathology, Tohoku Univ.
Takahashi
T
T
D000230:Adenocarcinoma / Q000098:blood supply* / Q000473:pathology; D001158:Arteries / Q000473:pathology; D003110:Colonic Neoplasms / Q000098:blood supply* / Q000473:pathology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000098:blood supply* / Q000473:pathology; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000473:pathology