Activity of porphobilinogen deaminase in peripheral blood mononuclear cells of patients with metastatic cancer.
Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral mononuclear cells of 60% of patients with epithelial tumors and metastatic spread, but only in 14% of patients with tumor and no evidence of metastases. The combination of both high lactic dehydrogenase and high PBGD afforded a sensitivity of 40%, but a specificity of 96% in diagnosing metastatic spread.
Leibovici
L
L
Department of Internal Medicine B, Beilinson Medical Center, Petah Tiqva, Israel.
Schoenfeld
N
N
Yehoshua
H A
HA
Mamet
R
R
Rakowsky
E
E
Shindel
A
A
Atsmon
A
A
D000328:Adult; D000368:Aged; D000642:Ammonia-Lyases / Q000097:blood*; D001943:Breast Neoplasms / Q000201:enzymology; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000201:enzymology; D006801:Humans; D011163:Hydroxymethylbilane Synthase / Q000097:blood*; D007963:Leukocytes, Mononuclear / Q000201:enzymology*; D008175:Lung Neoplasms / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000201:enzymology*; D010051:Ovarian Neoplasms / Q000201:enzymology
D011163:Hydroxymethylbilane Synthase; D000642:Ammonia-Lyases