title: Further evidence of a silent plasminogen (PLG) allele in two paternity cases.
abstract: Routine paternity testing has yielded two different cases of an apparent inverse homozygosity in the plasminogen (PLG) system. In one case, the child presented the phenotype PLG A and his putative father the type PLG B. The alleged father could not be excluded from the paternity in 25 additional blood group marker systems (biostatistical probability of paternity W greater than 99.75%). In the other case an incompatibility was found in a mother- child pair. Analysis of PLG was carried out by isoelectric focusing on neuraminidase-treated sera. In both cases the immunologic and functional detection showed weaker banding pattern of the affected PLG types. The assumption of a silent allele in the PLG system was confirmed by quantitative investigations. The allele frequency of PLG*Q0 in the South German population was estimated to be 0.0013. In the same sample the variant PLG A3 has been shown to be polymorphic.
authors.affiliation: Institut für Anthropologie und Humangenetik der Universität München, Federal Republic of Germany.
authors.forename: S
authors.initials: S
authors.lastname: Weidinger
authors.forename: W
authors.initials: W
authors.lastname: Patutschnick
authors.forename: F
authors.initials: F
authors.lastname: Schwarzfischer
mesh_terms: D000483:Alleles; D002648:Child; D005787:Gene Frequency; D005860:Germany, West; D006801:Humans; D008297:Male; D010334:Paternity; D010375:Pedigree; D010641:Phenotype; D010958:Plasminogen / Q000235:genetics*
chemical_list: D010958:Plasminogen