The gene encoding the large human neurofilament subunit (NF-H) maps to the q121-q131 region on human chromosome 22.
Using a rat cDNA probe encoding for the C-terminal extension of the large neurofilament subunit (NF-H), we have assigned, by in situ hybridization, the human NF-H gene to the q121-q131 region of chromosome 22. This localization may have implications in neurological diseases such as meningioma where a recessive locus involved in oncogenesis is located within this region.
Mattei
M G
MG
U-242 INSERM, Hôpital d'Enfants de la Timone, Marseille, France.
Dautigny
A
A
Pham-Dinh
D
D
Passage
E
E
Mattei
J F
JF
Jollès
P
P
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics*; D007621:Karyotyping; D016900:Neurofilament Proteins; D051381:Rats
D015342:DNA Probes; D007381:Intermediate Filament Proteins; D016900:Neurofilament Proteins; C051774:neurofilament protein H; D004247:DNA