title: Effects of renal artery pressure on interstitial pressure and Na excretion during renal vasodilation.
abstract: Renal vasodilation has a marked effect on the pressure-natriuresis relationship. The purpose of this study was to determine the role of renal interstitial hydrostatic pressure (RIHP) in mediating the effect of renal perfusion pressure (RPP) on urinary sodium excretion rate (UNaV) in control and vasodilated kidneys. The effects of RPP on UNaV and RIHP were determined in dogs under control conditions and during renal vasodilation with acetylcholine (Ach, 2.0 micrograms.kg-1.min-1) or secretin (SEC, 0.025 micrograms.kg-1.min-1). Decreases in RPP in control kidneys from 130 to 60 mmHg decreased UNaV from 2.9 +/- 0.1 to 0.6 +/- 0.3 microeq/min and fractional excretion of Na (FENa) from 0.15 +/- 0.08 to 0.06 +/- 0.04%. These changes were associated with significant reductions in RIHP (8.9 +/- 0.6 to 5.6 +/- 1.2 mmHg). In Ach-vasodilated kidneys, reductions in RPP from 130 to 60 mmHg decreased UNaV from 149.8 +/- 52.4 to 0.2 +/- 0.1 microeq/min and FENa from 3.42 +/- 1.18 to 0.012 +/- 0.01%. RIHP decreased from 17.8 +/- 3.4 to 8.4 +/- 1.3 mmHg, despite autoregulation of RBF. Renal vasodilation with SEC, which did not affect RIHP, had only a small effect on the relationship between RPP and UNaV. These data suggest that RIHP may be playing an important role in mediating the effect of RPP on UNaV.
authors.affiliation: Department of Physiology, Eastern Virginia Medical School, Norfolk 23501.
authors.forename: J P
authors.initials: JP
authors.lastname: Granger
authors.forename: J W
authors.initials: JW
authors.lastname: Scott
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D005110:Extracellular Space / Q000502:physiology*; D005260:Female; D005919:Glomerular Filtration Rate; D006706:Homeostasis; D006874:Hydrostatic Pressure; D007700:Kinetics; D008297:Male; D009318:Natriuresis; D012077:Renal Artery / Q000502:physiology*; D012079:Renal Circulation; D012633:Secretin / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects
chemical_list: D012633:Secretin; D000109:Acetylcholine