[Mutagenic activity of the pesticide hexachlorobutadiene].
Pesticide hexachlorobutadiene (HCBD) has been studied for its mutagenic activity in two test systems: in vivo and in vitro. The above pesticide manifested a mutagenic activity in the bone marrow cells under peroral and inhalation effect. No clastogenic action in the human peripheral lymphocyte culture was observed. Results of this study and data available in literature permit concluding that HCBD is an indirect mutagen.
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D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002070:Butadienes / Q000494:pharmacology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005659:Fungicides, Industrial / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D051379:Mice; D009153:Mutagens / Q000494:pharmacology*
D002070:Butadienes; D005659:Fungicides, Industrial; D009153:Mutagens; C001335:hexachlorobutadiene
O mutagennoĭ aktivnosti pestitsida geksakhlorbutadiena.