title: Granulocytic sarcoma of the small intestine preceding acute myelomonocytic leukemia with abnormal eosinophils and inv(16).
abstract: We report a case of preleukemic granulocytic sarcoma of the small intestine preceding the development of acute myelomonocytic leukemia with abnormal eosinophils and inversion of chromosome 16, inv(16)(p13q22). A literature review suggests that this is a recurring cytogenetic-clinicopathologic association and carries a favorable prognosis, especially if treated aggressively with antileukemic therapy at the time of diagnosis.
authors.affiliation: Department of Cell and Molecular Biology, Royal Cancer Hospital, Chester Beatty Laboratories, London, England.
authors.forename: S J
authors.initials: SJ
authors.lastname: Russell
authors.forename: F J
authors.initials: FJ
authors.lastname: Giles
authors.forename: D S
authors.initials: DS
authors.lastname: Thompson
authors.forename: D J
authors.initials: DJ
authors.lastname: Scanlon
authors.forename: H
authors.initials: H
authors.lastname: Walker
authors.forename: J D
authors.initials: JD
authors.lastname: Richards
mesh_terms: D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D004804:Eosinophils / Q000473:pathology*; D006801:Humans; D007414:Intestinal Neoplasms / Q000235:genetics* / Q000473:pathology; D007421:Intestine, Small; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged