Fatal Stevens-Johnson syndrome following urography with iopamidol in systemic lupus erythematosus.
A 46 year old white woman with active systemic lupus erythematosus developed a skin rash 8 hours after intravenous urography with the non-ionic contrast medium iopamidol. Severe Stevens-Johnson syndrome with erythema multiforme, intrahepatic cholestasis, pulmonary infiltrates and acute renal failure ensued, leading to her death. Although non-ionic contrast media are generally less toxic than traditional ionic agents, their use in patients with immunological disease may be hazardous.
Savill
J S
JS
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Barrie
R
R
Ghosh
S
S
Muhlemann
M
M
Dawson
P
P
Pusey
C D
CD
D005260:Female; D006801:Humans; D007479:Iopamidol / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008875:Middle Aged; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced*; D014567:Urography / Q000009:adverse effects
D007479:Iopamidol