title: Skeletal muscle lesions in turkeys associated with the feeding of monensin.
abstract: The feeding of monensin as a coccidiostat in three separate flocks of turkeys was associated with increased mortality, posterior paresis, and a skeletal muscle myopathy. Mortality attributed to the disease was 1.65%, 1.86%, and 4.80% in the three flocks. Samples of monensin-supplemented feed fed to the flocks when showing clinical signs contained 88, 85, and 106 g/ton of complete feed, respectively. Clinically, the turkeys showed posterior paresis, inability to rise, incoordination, reluctance to move, and leg trembling and weakness. Necropsy findings included consistent lesions of pallor within the type I muscles of the legs, wings, and backs. Microscopic lesions included myofiber degeneration and necrosis with massive cellular proliferation interpreted as sarcolemmal nuclei proliferation. Occasional axonal degeneration with loss of axons was present in peripheral nerves embedded in the damaged musculature. In the youngest flock, multifocal areas of acute coagulation necrosis of the myocardium were also present. These outbreaks occurred following intake of monensin in the complete feed at levels considered therapeutic; however, no associated predisposing clinical condition, drug/toxin interaction, or excessive monensin levels in the feed could be demonstrated.
authors.affiliation: Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
authors.forename: D P
authors.initials: DP
authors.lastname: Wages
authors.forename: M D
authors.initials: MD
authors.lastname: Ficken
mesh_terms: D000818:Animals; D008985:Monensin / Q000008:administration & dosage / Q000009:adverse effects*; D009132:Muscles / Q000473:pathology*; D009135:Muscular Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D011201:Poultry Diseases / Q000139:chemically induced* / Q000473:pathology; D014422:Turkeys
chemical_list: D008985:Monensin