Modulation of methylcholanthrene-induced carcinogenesis in the uterine cervix of mouse by indomethacin.
The present paper reports the chemopreventive action of indomethacin on methylcholanthrene (MCA)-induced carcinogenesis in the uterine cervix of virgin young adult Swiss albino mice. Placement of a sterile cotton thread impregnated with beeswax containing approx. 600 micrograms of MCA produces cervical tumors in 91% mice in 16 weeks. When such carcinogen-containing threads are inserted into the uterine cervix of mice fed diets containing indomethacin at the dose levels of 10 mg/kg, 20 mg/kg and 40 mg/kg diet for two pre-insertion weeks plus 16 post-insertion weeks, the cervical tumor incidences were 83%, 65% and 26% (P less than 0.01), respectively. It is concluded that indomethacin, when given in the diet at sufficiently high concentration, significantly inhibits MCA-induced cervical carcinogenesis.
Rao
A R
AR
Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Hussain
S P
SP
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D008748:Methylcholanthrene; D051379:Mice; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D008748:Methylcholanthrene; D007213:Indomethacin