Single-dose prophylaxis with cefotetan in elective abdominal surgery. A controlled trial.
Single dose cefotetan was compared with either a combination of metronidazole and cefazolin given for 24 hours or 3 doses of cefuroxime as prophylaxis in elective abdominal surgery. Wound infections and infections at remote sites (UTI and RTI) were similar in all groups. In a third group prophylaxis of abdominal surgery using a single 2g dose of cefotetan was compared to 2 doses of the same drug, given 12 hours apart. There was no demonstrable advantage to giving 2 doses. The low incidence of post-operative infections seen in all groups indicates the efficacy of cefotetan in the surgical prophylaxis of elective abdominal surgery.
Gruwez
J A
JA
Academic Hospital, Leuven, Belgium.
Lerut
J
J
Christiaens
M R
MR
De Roose
J
J
Vernimmen
L
L
Hendrickx
J
J
Trimpeneers
F
F
Schroé
H
H
Deruyter
M
M
Williams
K J
KJ
D000005:Abdomen / Q000601:surgery*; D002437:Cefazolin / Q000008:administration & dosage; D015313:Cefotetan / Q000008:administration & dosage*; D002444:Cefuroxime / Q000627:therapeutic use; D003106:Colon / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage; D011292:Premedication; D012007:Rectum / Q000601:surgery; D013530:Surgical Wound Infection / Q000517:prevention & control*
D008795:Metronidazole; D015313:Cefotetan; D002437:Cefazolin; D002444:Cefuroxime