A hybrid artificial vascular graft based upon an organ reconstruction model. Significance and design criteria of an artificial basement membrane.
The design of an artificial basement membrane is one of the central concerns in a hybrid artificial vascular graft. The design criteria defined here include 1) structural matrix, 2) enhanced adhesion and growth of endothelial cells, and 3) ensured antithrombogenicity. The designed artificial basement membrane is a complex gel of type I collagen with dermatan sulfate that drastically alters the cellular responses for both endothelial cells and platelets. The incorporation of a very small amount of dermatan sulfate was sufficient to enhance adhesion and growth of endothelial cells and to suppress platelet adhesion and activation.
Matsuda
T
T
National Cardiovascular Center Research Institute, Osaka, Japan.
Kitamura
T
T
Iwata
H
H
Takano
H
H
Akutsu
T
T
D000818:Animals; D001807:Blood Vessel Prosthesis; D002417:Cattle; D002448:Cell Adhesion; D003094:Collagen; D046508:Culture Techniques; D003871:Dermatan Sulfate; D004730:Endothelium, Vascular / Q000166:cytology*; D008567:Membranes, Artificial; D010973:Platelet Adhesiveness; D011474:Prosthesis Design
D008567:Membranes, Artificial; D003871:Dermatan Sulfate; D003094:Collagen