[Therapeutic results in Giardia lamblia infestation].
Therapeutic effects of metronidazole (Flagyl), tinidazole (Tricolam 500) and chlorhydrate of quinacrine in a study of 106 children with symptomatic giardiasis are compared. To evaluate results, cure percentage, efficacy and presence of secondary effects were quantified. Tinidazole was demonstrated most effective drug (96% effective) when compared with quinacrine (83.3% effective) and metronidazole (70.2%) (p less than 0.05). Authors recommend following regime: tinidazole 50-75 mg/kg divided in 2-3 doses, one day; chlorhydrate of quinacrine 6 mg/kg/day divided in 3 doses, five days; metronidazole 15-20 mg/kg/day divided in 3 doses, seven to ten days.
Martínez Costa
C
C
Departamento de Pediatría, Hospital Clínico Universitario, Valencia.
García Vila
A
A
Brines Solanes
J
J
Codoñer Franch
P
P
D002648:Child; D004341:Drug Evaluation; D005873:Giardiasis / Q000188:drug therapy*; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011796:Quinacrine / Q000008:administration & dosage / Q000627:therapeutic use*; D014011:Tinidazole / Q000008:administration & dosage / Q000627:therapeutic use*
D009593:Nitroimidazoles; D014011:Tinidazole; D008795:Metronidazole; D011796:Quinacrine
Resultados terapéuticos de la infestación por Giardia lamblia.