The genetic variation and the expression of human glutathione transferase mu.
A glutathione transferase from human leukocytes (GT-tSBO) with high activity towards trans-stilbene oxide has now been found to correspond to the hepatic class Mu glutathione transferase. This class, Mu, of transferase(s) has been found in high concentration in liver, kidney, and adrenal gland, judged by he activity of GT-tSBO. This activity is only found in some individuals, approximately 46%. By using a cDNA clone derived from class Mu transferase(s) from mouse, it is suggested that this enzyme is not transcribed, depending on a deletion (of a part) of a gene in those individuals that are lacking the activity towards tSBO.
Seidegård
J
J
Wallenberg Laboratory, University of Lund, Sweden.
Pero
R W
RW
D002874:Chromosome Mapping; D014644:Genetic Variation; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008099:Liver / Q000201:enzymology; D013267:Stilbenes / Q000378:metabolism
D007527:Isoenzymes; D013267:Stilbenes; D005982:Glutathione Transferase; C025906:stilbene oxide