title: Phase II trial of high-dose cytosine arabinoside and cisplatin in recurrent squamous carcinoma of the head and neck. A Piedmont Oncology Association Study.
abstract: Fifteen patients with recurrent squamous carcinoma of the head and neck received high-dose cytosine arabinoside (ara-C) (3 g/m2) and cisplatin (100 mg/m2) every 3 weeks in an attempt to explore the dose-dependent synergy between these two agents. A partial response was attained in one patient; there were no complete responses. The major toxicity was myelosuppression. With the current schedule, high-dose ara-C failed to improve the response rate achieved with cisplatin alone.
authors.affiliation: Oncology Research Center, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.
authors.forename: B L
authors.initials: BL
authors.lastname: Powell
authors.forename: J B
authors.initials: JB
authors.lastname: Craig
authors.forename: H B
authors.initials: HB
authors.lastname: Muss
authors.forename: P J
authors.initials: PJ
authors.lastname: Zekan
authors.forename: M R
authors.initials: MR
authors.lastname: Cooper
authors.forename: F M
authors.initials: FM
authors.lastname: Schnell
authors.forename: J W
authors.initials: JW
authors.lastname: Hampton
authors.forename: D R
authors.initials: DR
authors.lastname: White
authors.forename: L R
authors.initials: LR
authors.lastname: Smith
authors.forename: R L
authors.initials: RL
authors.lastname: Capizzi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*
chemical_list: D003561:Cytarabine; D002945:Cisplatin