[The role of cholinergic processes in realizing the analgesic effect of GABA-positive preparations].
In experiments on male rats it was shown that scopolamine diminished while pilocarpine and physostigmine potentiated the antinociceptive effect of baclofen, gamma-acetylenic-GABA, THIP and depakine. At the same time the antinociceptive effect of pilocarpine virtually underwent no changes in baclofen- and depakine-tolerant animals. The results suggest that the cholinergic processes may be involved in GABAergic antinociception but not in the development of tolerance to the antinociceptive effect of GABA-positive drugs.
Ignatov
Iu D
IuD
Andreev
B V
BV
D000625:Aminooxyacetic Acid / Q000037:antagonists & inhibitors; D000700:Analgesics; D000818:Animals; D004347:Drug Interactions; D004361:Drug Tolerance; D008297:Male; D009619:Nociceptors / Q000187:drug effects; D010277:Parasympathomimetics / Q000494:pharmacology; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism* / Q000494:pharmacology
D000700:Analgesics; D010277:Parasympathomimetics; D011950:Receptors, Cholinergic; D000625:Aminooxyacetic Acid; D005680:gamma-Aminobutyric Acid
O roli kholinergicheskikh protsessov v realizatsii boleutoliaiushchego éffekta GAMK-pozitivnykh preparatov.