title: Effect of copper fluoride and copper sulfate on dental plaque, Streptococcus mutans and caries in hamsters.
abstract: Topical applications of 10 mM CuF2, 10 mM CuSO4, or 20 mM NaF solutions were performed twice a day in hamsters infected with S. mutans and maintained on a high sucrose diet. Animals receiving the copper compounds exhibited lower plaque scores than control animals or animals treated with the NaF solution. The group receiving the CuF2 solution showed a lower number of S. mutans and a higher caries reduction than the groups treated with NaF or the non-fluoride compound CuSO4.
authors.affiliation: Department of Cariology, Faculty of Odontology, University of Gothenburg, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Maltz
authors.forename: C G
authors.initials: CG
authors.lastname: Emilson
mesh_terms: D000818:Animals; D003300:Copper / Q000627:therapeutic use*; D019327:Copper Sulfate; D006224:Cricetinae; D003731:Dental Caries / Q000517:prevention & control*; D003773:Dental Plaque / Q000517:prevention & control*; D005459:Fluorides / Q000627:therapeutic use*; D009055:Mouth / Q000382:microbiology; D012969:Sodium Fluoride / Q000627:therapeutic use; D013295:Streptococcus mutans / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: C057829:copper fluoride; D003300:Copper; D012969:Sodium Fluoride; D019327:Copper Sulfate; D005459:Fluorides