title: Relative bioavailability of oral low dose methotrexate. A comparison of 2 different formulations.
abstract: In 39 patients the bioavailability of methotrexate from the two tablets Emthexat 2.5 mg and Methotrexate 2.5 mg was assessed in a double-blind study after a single oral dose of 30 mg/m2 Methotrexate. There was a considerable inter-individual variation of the serum pharmacokinetics in regard to Cmax and tmax, independent on the MTX formulation. Emthexat 2.5 mg tablets and Methotrexate 2.5 mg tablets were bioequivalent according to the definition (AUCE greater than or equal to AUCM X 80%).
authors.affiliation: Department of Medical Oncology and Radiotherapy, Norwegian Radium Hospital, Oslo.
authors.forename: S D
authors.initials: SD
authors.lastname: Fosså
authors.forename: K
authors.initials: K
authors.lastname: Tveit
authors.forename: O
authors.initials: O
authors.lastname: Börmer
authors.forename: A
authors.initials: A
authors.lastname: Moxnes
authors.forename: N P
authors.initials: NP
authors.lastname: Jørgensen
authors.forename: H
authors.initials: H
authors.lastname: Orjaseter
authors.forename: D T
authors.initials: DT
authors.lastname: Kristoffersen
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013607:Tablets
chemical_list: D013607:Tablets; D008727:Methotrexate