title: Immunogenicity of a recombinant hepatitis B vaccine in hemophiliacs.
abstract: Yeast-recombinant vaccines against hepatitis B virus (HBV) are now available, but there is no information about whether or not they are immunogenic in patients with hemophilia and other congenital bleeding disorders. Twenty micrograms of a recombinant vaccine expressing the adw serotype of the hepatitis B surface antigen (HBsAg) were given to 41 patients negative for HBV markers and again after 1 and 6 months. Ten percent of the vaccinees had anti-hepatitis B surface antibody (anti-HBs) responses, with titers of 10 mIU/ml or more, 1 month after the first dose of vaccine. The percentage of anti-HBs-positive patients increased to 54% after the second dose and to 98% after the third dose, with only one non-responder. Hence, the recombinant vaccine was immunogenic, with percentages of seroconversion and anti-HBs titers similar to those achieved with plasma-derived vaccines.
authors.affiliation: Study Group of the Italian Hemophilia Foundation, Milan, Italy.
authors.forename: P M
authors.initials: PM
authors.lastname: Mannucci
authors.forename: A
authors.initials: A
authors.lastname: Gringeri
authors.forename: M
authors.initials: M
authors.lastname: Morfini
authors.forename: R
authors.initials: R
authors.lastname: De Biasi
authors.forename: M C
authors.initials: MC
authors.lastname: Tirindelli
authors.forename: G
authors.initials: G
authors.lastname: Tamponi
authors.forename: F
authors.initials: F
authors.lastname: Baudo
authors.forename: V
authors.initials: V
authors.lastname: Carnelli
authors.forename: N
authors.initials: N
authors.lastname: Ciavarella
authors.forename: M
authors.initials: M
authors.lastname: Colombo
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D006467:Hemophilia A / Q000276:immunology*; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D008875:Middle Aged; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines