A stochastic two-stage model for cancer risk assessment. I. The hazard function and the probability of tumor.
We present a mathematical treatment of a two-mutation model for carcinogenesis with time-dependent parameters. This model has previously been shown to be consistent with epidemiologic and experimental data. An approximate hazard function used in previous papers is critically evaluated.
Moolgavkar
S H
SH
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
Dewanji
A
A
Venzon
D J
DJ
D002273:Carcinogens; D003043:Cocarcinogenesis; D006801:Humans; D015233:Models, Statistical; D009369:Neoplasms / Q000209:etiology; D012306:Risk; D013269:Stochastic Processes
D002273:Carcinogens