Cold-induced peripheral nerve damage: involvement of touch receptors of the foot.
A 31-year-old male developed paresthesia and numbness of mainly the right foot following exposure to nonfreezing temperatures under moist conditions over a period of 1 week. The symptoms gradually improved over several months. When seen for electrophysiological studies 6 months after the injury, there was no sensory loss on clinical examination, although he continued to complain of distal numbness of the right foot. The right extensor digitorum brevis muscle was atrophic, and the distal motor latency in the peroneal nerve was prolonged. Conduction studies of the right sural nerve showed a predominantly distal diminution of the SAP evoked by electrical stimulation at the dorsum pedis. Action potentials evoked by tactile stimulation of Pacinian corpuscles showed a prolonged latency on the symptomatic side, suggesting that the most pronounced pathological changes in immersion injury may be localized to the very distal portion of the nerve at the nerve fiber-receptor junction.
Carter
J L
JL
Division of Neurology, Brigham and Women's Hospital, Boston, MA 02115.
Shefner
J M
JM
Krarup
C
C
D000200:Action Potentials; D000328:Adult; D003080:Cold Temperature / Q000009:adverse effects*; D005528:Foot / Q000294:innervation*; D006801:Humans; D007102:Immersion Foot / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D009431:Neural Conduction; D010292:Paresthesia / Q000209:etiology / Q000503:physiopathology; D011930:Reaction Time; D011984:Sensory Receptor Cells / Q000503:physiopathology*; D014110:Touch