title: Severe hemoptysis associated with pulmonary aspergilloma. Percutaneous intracavitary treatment.
abstract: Surgical therapy for massive hemoptysis associated with pulmonary aspergilloma carries a high morbidity and mortality in patients with limited pulmonary reserve. Bronchial artery embolization has proven ineffective in treating and in preventing recurrent episodes of hemoptysis in this group of patients. Over a four-and-one-half year period, we have successfully treated six episodes of acute hemoptysis in four patients using a percutaneously placed catheter and intracavitary instillation of amphotericin B, N-acetylcysteine, and aminocaproic acid. Advantages of this method of treatment for patients with severely compromised pulmonary reserve include: (1) no further loss of lung function; (2) ease and rapidity of catheter insertion; (3) prompt response to treatment; (4) relatively short hospitalization; and (5) ability to repeat the procedure in the same or another cavity if necessary.
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.
authors.forename: M J
authors.initials: MJ
authors.lastname: Shapiro
authors.forename: S M
authors.initials: SM
authors.lastname: Albelda
authors.forename: R L
authors.initials: RL
authors.lastname: Mayock
authors.forename: G K
authors.initials: GK
authors.lastname: McLean
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage / Q000627:therapeutic use*; D000614:Aminocaproates / Q000627:therapeutic use; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy*; D002404:Catheterization; D002408:Catheters, Indwelling; D005260:Female; D006469:Hemoptysis / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D000614:Aminocaproates; D000666:Amphotericin B; D000111:Acetylcysteine