[Analysis of the possible mechanisms for the persistence of the vaccinal strain of the measles virus in a human cell culture].
The mechanisms (factors) of the measles virus vaccine L-16 strain persistence in HEp-2 cell culture were analysed. Among the known mechanisms, most likely is the reduction of the cell-destroying properties of the persisting virus due to mutations in nucleoprotein gene manifested by changes of the isoelectric point of NP protein and temperature sensitivity of its synthesis.
Andzhaparidze
O G
OG
Bogomolova
N N
NN
Boriskin
Iu S
IuS
Koptiaeva
I B
IB
Chaplygina
N M
NM
D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D003673:Defective Viruses / Q000032:analysis / Q000502:physiology; D006801:Humans; D008459:Measles virus / Q000032:analysis / Q000502:physiology*; D009154:Mutation; D013997:Time Factors; D014762:Viral Interference; D014764:Viral Proteins / Q000032:analysis; D014776:Virus Cultivation
D014764:Viral Proteins
Analiz vozmozhnykh mekhanizmov persistentsii vaktsinnogo shtamma virusa kori v kul'ture kletok cheloveka.