Drug-protein interactions. On the protein-protein interaction induced by levamisole in vitro. A mechanism hypothesis.
In the present communication, a model is reported in order to explain the aggregation of albumin induced by levamisole in vitro. The hypothesis suggests that the process of polymerization of albumins may include ligand-protein interaction as a biochemical catalysis, and covalent protein-protein interactions by a mechanism of disulfide-sulfhydryl interchange by intramolecular or intermolecular reactions.
Chicault
M
M
Unité de Formation et de Recherche de Pharmacie, Université Joseph Fourier Grenoble, Meylan, France.
Luu Duc
C
C
Boucherle
A
A
D000418:Albumins / Q000378:metabolism*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D007978:Levamisole / Q000494:pharmacology*; D008024:Ligands; D008956:Models, Chemical; D011108:Polymers; D013438:Sulfhydryl Compounds / Q000378:metabolism
D000418:Albumins; D008024:Ligands; D011108:Polymers; D013438:Sulfhydryl Compounds; D007978:Levamisole