Effect of allyl isothiocyanate on hepatic monooxygenases and serum transferases in rats.
The effect of allyl isothiocyanate (AITC) on the activities of liver monooxygenases and serum transferases was investigated in male rats. AITC was given in oral doses of 0, 50, 100 or 150 mg/kg bw for 3 consecutive days. Increased relative liver weights and decreased activities of hepatic aminopyrine-N-demethylase, p-nitroanisole-O-demethylase and aniline-p-hydroxylase were observed in all treatment groups. The administration of AITC at dose levels of 100 and 150 mg/kg caused a statistically significant increase in the serum aspartate aminotransferase activity.
Lewerenz
H J
HJ
Academy of Sciences of the GDR, Central Institute of Nutrition, Potsdam-Rehbrücke.
Plass
R
R
Macholz
R
R
D000410:Alanine Transaminase / Q000097:blood; D000633:Aminopyrine N-Demethylase / Q000378:metabolism*; D000815:Aniline Hydroxylase / Q000378:metabolism*; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D001219:Aspartate Aminotransferases / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D017879:Isothiocyanates; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010088:Oxidoreductases / Q000378:metabolism*; D010090:Oxidoreductases, O-Demethylating / Q000378:metabolism*; D051381:Rats; D013861:Thiocyanates / Q000494:pharmacology*; D000637:Transaminases / Q000097:blood*
D017879:Isothiocyanates; D013861:Thiocyanates; C004471:allyl isothiocyanate; C026048:4-nitroanisole O-demethylase; D010088:Oxidoreductases; D010090:Oxidoreductases, O-Demethylating; D000815:Aniline Hydroxylase; D001189:Aryl Hydrocarbon Hydroxylases; D000633:Aminopyrine N-Demethylase; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase