Peliosis hepatis induced by 6-thioguanine administration.
A patient with acute myeloblastic leukaemia developed jaundice revealing peliosis hepatis after receiving 6-thioguanine for two months. Peliosis hepatis was severe and was associated with mild lesions of centrilobular veins. Withdrawal of 6-thioguanine was followed by a progressive improvement of liver dysfunction. This report shows that 6-thioguanine, a thiopurine already reported to be responsible for veno-occlusive disease of the liver, can induce peliosis hepatis. This suggests that some liver vascular disorders caused by thiopurines (6-thioguanine, azathioprine and 6-mercaptopurine), particularly peliosis hepatis, veno-occlusive disease, sinusoidal dilatation and perisinusoidal fibrosis, might be related syndromes caused by similar lesions at different sites.
Larrey
D
D
Unit157e de Recherches de Physiopathologie Hépatique (INSERM U 24), Hôpital Beaujon, Clichy, France.
Fréneaux
E
E
Berson
A
A
Babany
G
G
Degott
C
C
Valla
D
D
Pessayre
D
D
Benhamou
J P
JP
D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008875:Middle Aged; D010382:Peliosis Hepatis / Q000139:chemically induced*; D013866:Thioguanine / Q000008:administration & dosage / Q000009:adverse effects*
D013866:Thioguanine