Immunohistochemical study of intimal protein deposits in the aging vascular wall of normo- and hypertensive patients.
In an attempt to obtain immunohistochemical data of use for evaluating the severity and extent of intimal thickening (IT) in normo- and hypertensive patients small-sized arteries were analyzed by the immunoperoxidase staining technique for intimal deposition of albumin, fibrinogen, IgG, IgM and beta-lipoprotein. The material included surgical biopsies from 143 temporal arteries and matched autopsy samples of temporal- and interlobar renal arteries from 33 patients. The intimal protein deposits were found to reflect the presence of IT but not the state of hypertension. comparisons between the matched temporal and renal arteries showed rank correlation regarding IT as well as deposition of fibrinogen, IgG and beta-lipoprotein. However, fibrinogen was the only protein, which also showed congruous mean values for the two different arterial types. We therefore conclude that out of the 5 proteins examined in this study, fibrinogen appears to be the most reliable marker of IT in small-sized arteries.
Fischer
S
S
Department of Pathology, Fredeiksberg Hospital, University of Copenhagen, Denmark.
Christensen
L
L
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000418:Albumins / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000378:metabolism* / Q000473:pathology; D007136:Immunoglobulins / Q000378:metabolism; D007150:Immunohistochemistry; D008077:Lipoproteins, LDL / Q000378:metabolism; D008875:Middle Aged; D011506:Proteins / Q000378:metabolism*; D012077:Renal Artery / Q000378:metabolism* / Q000473:pathology; D013699:Temporal Arteries / Q000378:metabolism* / Q000473:pathology
D000418:Albumins; D007136:Immunoglobulins; D008077:Lipoproteins, LDL; D011506:Proteins; D005340:Fibrinogen