title: Reference values for fructosamine concentrations in children's sera: influence of protein concentration, age, and sex.
abstract: Fructosamine and protein (total and fractionated) were measured in the serum of 170 normal children, ages two weeks to 15 years. The mean fructosamine concentration was 2.12 mmol/L, 5% lower than the mean value observed for adults. We observed no sex-related difference in fructosamine values, but saw a pronounced age dependency of reference values. For children younger than three years, the mean concentration of fructosamine was 15% lower than in adults, but glycated protein concentrations increased with age, reaching essentially adult values by age six years. Expressing fructosamine concentrations per gram of serum total protein or of albumin weakened the influence of age, but did not eliminate it completely. We report reference intervals for fructosamine concentrations in children's sera.
authors.affiliation: Department of Pediatrics, Academic Hospital and Medical School, Vrije Universiteit Brussel, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: De Schepper
authors.forename: M P
authors.initials: MP
authors.lastname: Derde
authors.forename: P
authors.initials: P
authors.lastname: Goubert
authors.forename: F
authors.initials: F
authors.lastname: Gorus
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001798:Blood Proteins / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D019270:Fructosamine; D006595:Hexosamines / Q000097:blood*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012016:Reference Values; D012737:Sex Factors
chemical_list: D001798:Blood Proteins; D006595:Hexosamines; D019270:Fructosamine