Sulfonamide-induced pancreatitis.
While reported cases of sulfonamide-induced pancreatitis meet many criteria for an allergic drug reaction, antibody or lymphocyte recognition of the offending drug or its metabolite has yet to be demonstrated. A patient with sulfonamide-induced pancreatitis is reported in whom lymphocytes were stimulated in vitro by sulfamethoxazole, sulfapyridine, and sulfasalazine. Lymphocytes from a normal volunteer were not stimulated. This in vitro lymphocyte recognition of sulfonamides provides further evidence that sulfonamide-induced pancreatitis is an allergic drug reaction.
Brazer
S R
SR
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
Medoff
J R
JR
D000328:Adult; D004342:Drug Hypersensitivity; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced*; D013449:Sulfonamides / Q000009:adverse effects*
D013449:Sulfonamides