title: Partitioning of large and small airway resistance in human measured by an anterograde catheter with a tip micromanometer.
abstract: We measured lateral pressure in airways 3 mm in internal diameter in three normal subjects using an anterograde catheter with a tip micromanometer. The pressure was used to partition total pulmonary resistance into a large airway resistance component between the mouth and the pressure sensor and a small airway resistance component between the pressure sensor and alveoli. Large airway resistance and small airway resistance during inspiration were 2.3 +/- 0.4 and 0.9 +/- 0.2 cmH2O/liter/sec (mean +/- S.E.), respectively, and small airway resistance was 29% of the total pulmonary resistance. We suggest that the present technique may be useful for determining the localization of airway resistance in human subjects.
authors.affiliation: First Department of Internal Medicine, Tohoku University School of Medicine, Sendai.
authors.forename: T
authors.initials: T
authors.lastname: Takishima
authors.forename: M
authors.initials: M
authors.lastname: Yanai
authors.forename: K
authors.initials: K
authors.lastname: Sekizawa
authors.forename: T
authors.initials: T
authors.lastname: Ohrui
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Ozawa
mesh_terms: D000328:Adult; D000403:Airway Resistance; D002406:Catheterization, Peripheral / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D008168:Lung / Q000502:physiology*; D008875:Middle Aged