[Endoscopic study of gastric tolerance of paracetamol and acetylsalicylic acid. A placebo-controlled double-blind study on healthy subjects].
Endoscopic Studies on the Gastric Tolerance of Paracetamol and Acetylsalicylic Acid/A placebo-controlled double-blind study in healthy volunteers. In placebo-controlled randomized double-blind cross-over fashion the gastric and duodenal tolerance of 1000 mg acetylsalicylic acid (ASA; as a commercially available preparation and 1000 mg paracetamol (Tylenol) were directly compared in 12 healthy volunteers. An endoscopic evaluation of the gastric and duodenal mucosa was performed. 1000 mg ASA evoked a lesion score of 2.5 whereas 1000 mg paracetamol and placebo displayed a score of 1.0 and 0.92, respectively. This difference between paracetamol and ASA reached a statistical significance. Based on the comparable analgetic potency of both compounds and the apparently better gastro-duodenal tolerability paracetamol is the drug of choice when a non-inflammatory problem requires an analgesic.
Müller
P
P
Gastroenterologischen Abteilung der Medizinischen Universitätsklinik Heidelberg.
Dammann
H G
HG
Simon
B
B
D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D004311:Double-Blind Method; D004386:Duodenum / Q000187:drug effects; D005773:Gastroscopy; D006801:Humans; D008297:Male; D011897:Random Allocation; D013276:Stomach Ulcer / Q000139:chemically induced*
D000082:Acetaminophen; D001241:Aspirin
Endoskopische Untersuchungen zur Magenverträglichkeit von Paracetamol und Acetylsalicylsäure. Eine Plazebo-kontrollierte Doppelblindstudie an gesunden Probanden.