Peripheral neuroepithelioma in childhood. Immunohistochemical demonstration of epithelial differentiation.
Peripheral neuroepithelioma arising from the chest wall of a 4-year-old girl is described. She died of local recurrence 15 months after surgery. Light- and electron-microscopic as well as immunohistochemical findings confirmed the neuroectodermal nature of the tumor. A distinctive histologic feature was the presence of clustered epitheliallike cells, which immunohistochemically stained positive for both keratin and carcinoembryonic antigen. The epithelial nature of these peculiar cells is presented.
Shinoda
M
M
Department of Pathology, Tokai University School of Medicine, Isehara, Japan.
Tsutsumi
Y
Y
Hata
J
J
Yokoyama
S
S
D002272:Carcinoembryonic Antigen / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002675:Child, Preschool; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000032:analysis / Q000473:pathology*; D013899:Thoracic Neoplasms / Q000032:analysis / Q000473:pathology*
D002272:Carcinoembryonic Antigen