Arizonins, a new complex of antibiotics related to kalafungin. I. Taxonomy of the producing culture, fermentation and biological activity.
The arizonins, a novel complex of antibiotics related to kalafungin, were discovered in the fermentation broth of Actinoplanes sp. AB660D-122. Comparative taxonomic studies indicated that the culture is a new species and therefore has been designated Actinoplanes arizonaensis sp. nov. Two members of the complex, arizonins A1 and B1, exhibit moderate to potent in vitro antimicrobial activity against pathogenic strains of Gram-positive bacteria.
Karwowski
J P
JP
Anti-infective Research Division, Abbott Laboratories, North Chicago, Illinois.
Jackson
M
M
Theriault
R J
RJ
Prokop
J F
JF
Maus
M L
ML
Hansen
C F
CF
Hensey
D M
DM
D000192:Actinomycetales / Q000145:classification* / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification*; D000935:Antifungal Agents / Q000096:biosynthesis / Q000302:isolation & purification; D002175:Candida / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009285:Naphthoquinones; C057560:arizonin A1; C057562:arizonin B1