Translocation (X;19) with involvement of the inactive X chromosome in oligoblastic granulocytic leukemia.
A 72-year-old female with metastatic breast cancer developed oligoblastic granulocytic leukemia 6 months after initiation of chemotherapy. Cytogenetic examination of the bone marrow cells revealed a balanced t(X;19)(q12;q13.3) as the sole abnormality in 50% of the metaphases. The remaining cells showed a normal female karyotype. The der(19) chromosome displayed consistent folding in the Xq13-q23 region in all metaphases, indicating involvement of the inactive X chromosome in translocation.
Gibas
Z
Z
Department of Pathology, Medical College of Pennsylvania, Philadelphia.
Gibas
L M
LM
Filomena
C A
CA
Sprandio
J
J
Jackson
L G
LG
D000368:Aged; D002888:Chromosomes, Human, Pair 19; D004303:Dosage Compensation, Genetic; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic; D014960:X Chromosome