Evaluation of various antibiotics for induction of L forms from Staphylococcus aureus strains isolated from bovine mastitis.
Forty-five strains of Staphylococcus aureus were treated with 11 antibiotics and tested for induction to L forms. Thirty-seven strains were induced to L forms with at least one antibiotic, while eight strains produced no L forms under the conditions used. L forms were induced only with beta-lactam antibiotics and with a combination of penicillin and streptomycin. Novobiocin induced no true L forms but induced intermediate forms from seven strains. Strains resistant to penicillin yielded L forms only with beta-lactam antibiotics active against penicillin-resistant organisms. Strains failing to yield L forms were susceptible to the antibiotics used, and resistance appeared to play no role in the induction of L forms with these strains.
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Mastitis Research Laboratory, Louisiana State University Agricultural Center, Homer 71040.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002417:Cattle; D005260:Female; D007740:L Forms / Q000187:drug effects*; D008414:Mastitis, Bovine / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents