The effects of the 5 HT2 antagonist ketanserin in adult atopic asthma.
We have studied eight adult atopic asthmatic patients in a randomized double-blind, placebo-controlled, cross-over trial in order to examine the effects of the 5 HT2 antagonist ketanserin on airways function (FEV1, FVC, V50(chi), and V25(pi]. Ketanserin did not significantly change resting bronchomotor tone. Treadmill exercise caused a similar maximal percentage fall in FEV1 after both drug [16.8 (3.7)%] and placebo [19.2 (4.2)%]; ketanserin did not significantly attenuate bronchoconstriction, measured over a 20-min period after exercise. These results suggest that 5 HT2 receptors do not play a major role in the control of resting bronchomotor tone or in exercise-induced bronchoconstriction in adult atopic asthmatic patients.
Stott
D J
DJ
MRC Blood Pressure Unit, Western Infirmary, Glasgow, UK.
Roberts
J A
JA
Thomson
N C
NC
Ball
S G
SG
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000503:physiopathology*; D001250:Asthma, Exercise-Induced / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007650:Ketanserin / Q000097:blood / Q000494:pharmacology*; D008297:Male; D005082:Physical Exertion; D012123:Pulmonary Ventilation; D011897:Random Allocation; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors; D014797:Vital Capacity
D007650:Ketanserin