title: Fragile X syndrome: linkage analysis in black and white populations.
abstract: Eleven white families and 10 black families have been studied to detect racial differences in the linkage of DNA markers flanking the fragile X site (FRAXA). The differences in the recombination fractions for F9-FRAXA and DX13-FRAXA were not significant. The pair St14-FRAXA exhibited no difference between the two groups. Although the sample size was small, it would appear that these DNA markers can be used in black persons for prenatal diagnosis and genetic counseling. A larger group of families would be necessary to determine if 4D8 and cX55.7 will be equally useful since these appear to have lower heterozygote frequencies in the black population.
authors.affiliation: Greenwood Genetic Center, SC 29646.
authors.forename: C E
authors.initials: CE
authors.lastname: Schwartz
authors.forename: M C
authors.initials: MC
authors.lastname: Phelan
authors.forename: C
authors.initials: C
authors.lastname: Brightharp
authors.forename: I
authors.initials: I
authors.lastname: Pancoast
authors.forename: P N
authors.initials: PN
authors.lastname: Howard-Peebles
authors.forename: S
authors.initials: S
authors.lastname: Thibodeau
authors.forename: W T
authors.initials: WT
authors.lastname: Brown
authors.forename: E C
authors.initials: EC
authors.lastname: Jenkins
mesh_terms: D044383:Black People / Q000235:genetics*; D015342:DNA Probes; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D010375:Pedigree; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D015342:DNA Probes; D005819:Genetic Markers