[The effect of somatotropin on adenosine deaminase activity in tissues of rats with hypo- and hyperthyroidism].
It has been shown that under hypothyrosis (thyroidectomy) the adenosine deaminase activity in the total suspension of thymocytes does not change as compared with that of intact rats. When suspension of thymocytes was separated by centrifugation in the ficoll-urografin density gradient into 6 fractions the enzyme activity has been found to increase by 83 and 31%, respectively, in light fractions with the ficoll density of 1.065 and 1.071 and to decrease by 21% in the fraction with density of 1.095 as compared with the intact rats. The enzyme activity in spleen homogenate of hypothyroid rats is higher by 72% than the norm. This activity in thymocytes and spleen of hyperthyroid rats is lower by 37% and 30% respectively. Somatotropin administration to rats normalizes these changes.
Litvinenko
E A
EA
D000243:Adenosine Deaminase / Q000378:metabolism*; D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D002469:Cell Separation; D002499:Centrifugation, Density Gradient; D013006:Growth Hormone / Q000494:pharmacology*; D006980:Hyperthyroidism / Q000201:enzymology*; D007037:Hypothyroidism / Q000201:enzymology*; D008099:Liver / Q000201:enzymology; D008297:Male; D009700:Nucleoside Deaminases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000201:enzymology; D013950:Thymus Gland / Q000201:enzymology
D058892:Adenosine Deaminase Inhibitors; D013006:Growth Hormone; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase
Vliianie somatotropina na aktivnost' adenozindezaminazy v tkaniakh krys s gipo- i gipertireozom.