title: Alpha-globin gene haplotypes in Polynesians: their relationships to population groups and gene rearrangements.
abstract: Five hundred two alpha-globin gene haplotypes were established in three Polynesian populations, Samoans, Maoris, and Niueans. Limited diversity of haplotypes was found in Polynesians, in whom six common haplotypes (Ia, IIa, IId, IIe, IIIa, and IVa) predominate. Haplotypes Ia and IIa enable Polynesians to be distinguished from Melanesians. Differences in haplotype profiles between the above Polynesian populations support their separate clustering on the basis of previous globin gene analyses and proposed theories of migration. The -alpha/, alpha alpha alpha/, -zeta/, and zeta zeta zeta/rearrangements are each associated exclusively with a particular haplotype, providing evidence of a single evolutionary origin for each. Therefore, a minimum of four DNA crossover events account for the separate origins of these rearrangements in the Polynesians.
authors.affiliation: Clinical Immunology Research Centre, University of Sydney, N.S.W., Australia.
authors.forename: M S
authors.initials: MS
authors.lastname: Hertzberg
authors.forename: K N
authors.initials: KN
authors.lastname: Mickleson
authors.forename: R J
authors.initials: RJ
authors.lastname: Trent
mesh_terms: D002874:Chromosome Mapping; D003434:Crossing Over, Genetic; D015321:Gene Rearrangement; D005914:Globins / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D011114:Polynesia
chemical_list: D005914:Globins