title: Measurement by spectrophotometer of blood cholinesterases inactivation following single oral doses of phosphamidon in Bubalus bubalis.
abstract: The effect of phosphamidon on blood cholinesterases (ChE) was investigated in male buffalo calves following single oral doses of 20, 40 and 80 mg/kg body wt. Phosphamidon at all 3 doses levels significantly inactivated erythrocyte and plasma ChE (66-98 and 67-89%, respectively) within 8-12 hr of administration. The inhibition was dose dependent, and the extent of inactivation of blood ChE correlated well with severity of toxicity following all phosphamidon doses.
authors.affiliation: Department of Pharmacology, Bangladesh Agricultural University, Mymensingh.
authors.forename: M A
authors.initials: MA
authors.lastname: Awal
authors.forename: J K
authors.initials: JK
authors.lastname: Malik
authors.forename: H S
authors.initials: HS
authors.lastname: Sandhu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002020:Buffaloes; D002802:Cholinesterases / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D010707:Phosphamidon / Q000633:toxicity*; D013053:Spectrophotometry
chemical_list: D007306:Insecticides; D010707:Phosphamidon; D002802:Cholinesterases