DNA damage in stomach, kidney, liver and lung of rats treated with atrazine.
The genotoxic activity of atrazine, a widely used triazine herbicide, was assayed by the DNA alkaline elution technique in rats given orally a single high dose or repeated daily doses. DNA breaks (and/or alkali-labile lesions) were detected in cell suspensions obtained from stomach, kidney and liver, but not in those from lung.
Pino
A
A
Institute of Pharmacology, University of Genoa, Italy.
Maura
A
A
Grillo
P
P
D000818:Animals; D001280:Atrazine / Q000494:pharmacology*; D004249:DNA Damage; D005260:Female; D007668:Kidney / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure; D008168:Lung / Q000648:ultrastructure; D009153:Mutagens; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000648:ultrastructure
D009153:Mutagens; D001280:Atrazine