Hamartomatous solitary polyp with malignant progression in the jejunum. A histochemical and immunohistochemical study by light and electron microscopy.
A case of solitary hamartomatous jejunal polyp with adenomatous and carcinomatous changes in a 16-year-old girl is reported. In the hamartomatous polyp, neutral and acid non-sulfate mucosubstance was detected, principally in goblet cells; carcinoembryonic antigen was demonstrated on the surfaces of the microvilli and luminal border of the crypts and glands; absorptive columnar, goblet, argentaffin, argyrophil and Paneth cells were evident. The adenomatous and, mainly, the carcinomatous areas revealed a decreased amount of mucosubstance and a variable degree of positive intracytoplasmic staining for carcinoembryonic antigen. With electron microscopy, the adenomatous areas showed columnar absorptive cells and mucus-secreting goblet cells; also immature columnar cells were observed in the dysplastic zones. To our knowledge, this is the first study to document the histochemical, immunohistochemical and ultrastructural features of a hamartomatous polyp with neoplastic transformation.
Aneiros
J
J
Department of Pathology, University of Granada, School of Medicine, Spain.
Matamala
M
M
Garcia del Moral
R
R
Lopez
J J
JJ
Aguilar
D
D
Camara
M
M
D000293:Adolescent; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005260:Female; D006222:Hamartoma / Q000175:diagnosis / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007417:Intestinal Polyps / Q000175:diagnosis / Q000473:pathology*; D007580:Jejunal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008854:Microscopy, Electron