Canine congenital portosystemic encephalopathy.
The case records of 21 dogs with congenital portosystemic encephalopathy are reviewed. The disorder was most common in Australian cattledogs (blue heelers; 8 cases), Old English sheepdogs (3 cases) and Maltese terriers (3 cases). Extra-hepatic shunts occurred in small breeds, with the exception of 1 cattledog, while intra-hepatic shunts occurred in the medium to large breeds. The most common clinical pathology abnormalities were abnormal ammonia tolerance, mild to moderate increases in plasma alanine aminotransferase or alkaline phosphatase concentrations, decreased total serum protein concentrations, increased fasting ammonia concentrations and ammonium biurate crystalluria. Radiological examination revealed that all the dogs had a small liver. The kidneys were enlarged in 5 of 10 dogs in which kidney size could be estimated. Surgical ligation of an extra-hepatic shunt was successful in 2 of 4 dogs in which it was attempted. Medical management resulted in alleviation of clinical signs in 5 of 8 dogs. The period of successful treatment ranged from a few months to over a year.
Maddison
J E
JE
Department Veterinary Clinical Studies, University of Sydney, New South Wales.
D000641:Ammonia / Q000097:blood; D000818:Animals; D004283:Dog Diseases / Q000151:congenital* / Q000000981:diagnostic imaging / Q000378:metabolism; D004285:Dogs; D005260:Female; D006501:Hepatic Encephalopathy / Q000151:congenital / Q000000981:diagnostic imaging / Q000378:metabolism / Q000662:veterinary*; D008297:Male; D011169:Portal Vein / Q000000981:diagnostic imaging; D011172:Portography
D000641:Ammonia