title: Translocations t(15;17) and t(9;14)(q34;q22) in a case of acute promyelocytic leukemia with increased number of basophils.
abstract: A patient with a variant form of acute promyelocytic leukemia (M3 variant) associated with an increased number of basophils was found to present a reciprocal translocation, t(9;14)(q34;q22) in addition to t(15;17)(q22;q12). Although several cases of acute nonlymphocytic leukemia with increased bone marrow and peripheral blood basophils have been reported, this is the first case in which both the t(9;14) and basophilia were observed in a patient with M3. Our findings support the hypothesis that 9q34 may be associated with the chromosomal location of genes regulating the production and maturation of basophils.
authors.affiliation: Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Gotoh
authors.forename: S
authors.initials: S
authors.lastname: Murakami
authors.forename: N
authors.initials: N
authors.lastname: Oku
authors.forename: K
authors.initials: K
authors.lastname: Itoh
authors.forename: N
authors.initials: N
authors.lastname: Takeda
authors.forename: N
authors.initials: N
authors.lastname: Fujita
authors.forename: C
authors.initials: C
authors.lastname: Shimazaki
authors.forename: A
authors.initials: A
authors.lastname: Nishio
authors.forename: H
authors.initials: H
authors.lastname: Haruyama
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
mesh_terms: D000328:Adult; D001491:Basophils / Q000473:pathology*; D002883:Chromosomes, Human, Pair 14; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007621:Karyotyping; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics* / Q000473:pathology; D007958:Leukocyte Count; D008297:Male; D014178:Translocation, Genetic