Effect of elevated potassium concentration in the perilymph on the nonlinearity of cochlear microphonics in the guinea-pig cochlea.
Various characteristics of cochlear microphonic responses (CM) were measured in the guinea-pig after perfusing scala tympani with KCl solutions. In addition to a decrease of CM magnitude, the nonlinearity and the symmetry of waveform showed typical modifications suggesting, in addition to a depolarization of hair cells, some mechanical alterations.
Avan
P
P
Laboratoire de Neurophysiologie, Collège de France, Paris.
Legouix
J P
JP
D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D003055:Cochlear Microphonic Potentials / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects; D010498:Perilymph / Q000502:physiology; D011189:Potassium Chloride / Q000494:pharmacology*; D012533:Scala Tympani / Q000187:drug effects
D011189:Potassium Chloride