Spiramycin concentrations in lung tissue.
Spiramycin concentrations in lung tissue were studied in patients undergoing pulmonary surgical procedures. The first group of six patients received 500 mg spiramycin iv 16 h before surgery and 500 mg at anaesthetic induction (total 1 g). The second group of six patients received three doses of 500 mg spiramycin iv 24, 16 and 8 h before surgery, and 500 mg at anaesthetic induction (total 2 g). Samples were taken from lung tissue, pleura, fat tissue and muscle. In group 1, the mean lung tissue concentration of spiramycin was 1.15 +/- 0.14 mg/kg and 7.99 +/- 2.02 mg/kg in group 2 (P less than 0.02). The differences in concentration in pleura, fat tissue and muscle samples between treatment groups 1 and 2 were not statistically significant.
Kitzis
M
M
Department of Surgery, Hôpital Beujon, Clichy, France.
Desnottes
J F
JF
Brunel
D
D
Giudicelli
A
A
Jacotot
F
F
Andreassian
B
B
D006801:Humans; D007933:Leucomycins / Q000032:analysis / Q000493:pharmacokinetics*; D008168:Lung / Q000032:analysis*; D008297:Male; D008875:Middle Aged
D007933:Leucomycins