title: [Radioprotective activity of complexes of copper, cobalt and zinc with substituted acylhydrazones].
abstract: Acylhydrazone metal complexes belong to a new class of radioprotective agents that have a cytostatic effect increasing, in some cases, the survival rate of irradiated animals by 40-60 per cent compared to irradiated controls. The most active drugs are hypotoxic and applied in much lower doses than ordinary S-containing radioprotective agents to achieve the same protective effect.
authors.forename: O V
authors.initials: OV
authors.lastname: Arapov
authors.forename: L S
authors.initials: LS
authors.lastname: Arestova
authors.forename: O F
authors.initials: OF
authors.lastname: Alferova
authors.forename: I I
authors.initials: II
authors.lastname: Krasil'nikov
authors.forename: L A
authors.initials: LA
authors.lastname: Khorseeva
mesh_terms: D000818:Animals; D003035:Cobalt / Q000627:therapeutic use / Q000633:toxicity; D003300:Copper / Q000627:therapeutic use / Q000633:toxicity; D006835:Hydrazones / Q000627:therapeutic use* / Q000633:toxicity; D008670:Metals / Q000627:therapeutic use* / Q000633:toxicity; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use* / Q000633:toxicity; D015032:Zinc / Q000627:therapeutic use / Q000633:toxicity
chemical_list: D006835:Hydrazones; D008670:Metals; D011837:Radiation-Protective Agents; D003035:Cobalt; D003300:Copper; D015032:Zinc
vernacular_title: Radiozashchitnaia aktivnost' kompleksov medi, kobal'ta i tsinka s zameshchennymi atsilgidrazonami.