title: Objective measurement of surfactant irritation by fiber optic spectroscopy.
abstract: Erythema caused by occlusion of 3 concentrations of surfactant was quantified in vivo using a modified spectrophotometer. Standard chamber irritation test sites were evaluated objectively using the spectrophotometer and subjectively by trained observers. There was a good relationship between the instrumental and visual evaluations. The spectrum was analyzed and a region was chosen to optimize the sensitivity of the method.
authors.affiliation: Department of New Science and Technology, Dial Technical Center, Scottsdale, AZ 85254.
authors.forename: D M
authors.initials: DM
authors.lastname: Crowe
authors.forename: M S
authors.initials: MS
authors.lastname: Willard
authors.forename: R I
authors.initials: RI
authors.lastname: Murahata
authors.forename: L B
authors.initials: LB
authors.lastname: Aust
authors.forename: M C
authors.initials: MC
authors.lastname: Gacula
mesh_terms: D000328:Adult; D000368:Aged; D003877:Dermatitis, Contact / Q000473:pathology*; D004890:Erythema / Q000473:pathology*; D005260:Female; D005336:Fiber Optic Technology; D006801:Humans; D007509:Irritants / Q000009:adverse effects; D008875:Middle Aged; D055100:Optical Fibers; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects; D013053:Spectrophotometry / Q000295:instrumentation / Q000379:methods*; D013501:Surface-Active Agents / Q000009:adverse effects
chemical_list: D007509:Irritants; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate