title: The maintenance of single-locus polymorphism. I. Numerical studies of a viability selection model.
abstract: The ability of viability selection to maintain single-locus polymorphism is investigated with two models in which the population is bombarded with a series of mutations with random fitnesses. In the first model, the population is allowed to reach equilibrium before mutation resumes; in the second the iterations and mutation occur simultaneously. Monte Carlo simulations of these models show that viability selection is easily able to maintain stable 6- or 7-allele polymorphisms and that monomorphisms and diallelic polymorphisms are uncommon. The question of how monomorphisms arise is also discussed.
authors.affiliation: Department of Biological Sciences, Stanford University, California 94305.
authors.forename: H G
authors.initials: HG
authors.lastname: Spencer
authors.forename: R W
authors.initials: RW
authors.lastname: Marks
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D008957:Models, Genetic; D009154:Mutation; D011110:Polymorphism, Genetic; D012641:Selection, Genetic