Blindness in a dog with IgA-forming myeloma.
A 9-year-old dog with a 2-month history of weight loss and a 1-week history of blindness had an IgA-forming myeloma. Seemingly, the blindness was a result of bilaterally detached retinas. The dog also had leukopenia, anemia, hypoalbuminemia, hyperglobulinemia, and proteinuria as well as lytic lesions in the cervical portion of the spine and high IgA concentrations in serum and urine. Evaluation of aspirates from the subretinal spaces revealed lymphocytes in a proteinaceous fluid. Histologically, retinal lesions consisted of vascular endothelial cell damage and intraretinal cysts and hemorrhages.
Kirschner
S E
SE
Department of Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames 50011.
Niyo
Y
Y
Hill
B L
BL
Betts
D M
DM
D000818:Animals; D001766:Blindness / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000209:etiology* / Q000473:pathology; D004285:Dogs; D007070:Immunoglobulin A / Q000096:biosynthesis*; D008297:Male; D009101:Multiple Myeloma / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D012163:Retinal Detachment / Q000209:etiology / Q000473:pathology / Q000662:veterinary*
D007070:Immunoglobulin A