title: Identification of an endothelial cell product as an inhibitor of tissue factor activity.
abstract: An endothelial cell glycoprotein that inhibits the initiation of the coagulation process promoted by tissue factor has been isolated by heparin-sepharose, hydroxyapatite and gel filtration chromatography. As is the case for several other species synthesized by this cell type, the N-linked carbohydrate moiety is sulfated. The identification of this inhibitor hints at the possible existence of a functional balance, between the activator of the coagulation cascade and its inhibitor, which may become perturbed in various pathophysiological conditions.
authors.affiliation: W. Alton Jones Cell Science Center, Lake Placid, New York 12946.
authors.forename: P
authors.initials: P
authors.lastname: Colburn
authors.forename: V
authors.initials: V
authors.lastname: Buonassisi
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000502:physiology*; D006023:Glycoproteins / Q000302:isolation & purification / Q000494:pharmacology*; D008970:Molecular Weight; D011817:Rabbits; D013925:Thromboplastin / Q000037:antagonists & inhibitors*
chemical_list: D006023:Glycoproteins; D013925:Thromboplastin