title: The effect of fish oil on lipids, coagulation and fibrinolysis in patients with angina pectoris.
abstract: The effect of fish oil on lipids, coagulation and fibrinolysis was investigated in patients with stable angina pectoris. The patients were given a daily supplement of 4.5 g n-6 polyunsaturated fatty acids (PUFA's) for 4 weeks and were then randomized to the same oil or to fish oil (4.5 g n-3 PUFA's) for 12 weeks. Blood samples were taken before and after 16 weeks of oil supplementation. Lipids, coagulation and fibrinolysis were measured in 14 patients treated with fish oil. There was a significant decrease in triglycerides and very low density lipoproteins but unexpectedly a significant increase in total cholesterol from 5.9 to 6.7 mmol/l after fish oil. The fibrinolytic activity at rest determined by the fibrin plate method showed a decrease after fish oil. Other measurements did not reveal any statistically significant changes. These finding necessitate caution with uncontrolled supplementation with fish oil in patients with stable angina pectoris.
authors.affiliation: Department of Clinical Chemistry, Aalborg Hospital, Denmark.
authors.forename: E B
authors.initials: EB
authors.lastname: Schmidt
authors.forename: S D
authors.initials: SD
authors.lastname: Kristensen
authors.forename: J
authors.initials: J
authors.lastname: Dyerberg
mesh_terms: D000787:Angina Pectoris / Q000097:blood / Q000178:diet therapy*; D001777:Blood Coagulation; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use*; D004281:Docosahexaenoic Acids; D004338:Drug Combinations; D015118:Eicosapentaenoic Acid; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation
chemical_list: D004042:Dietary Fats, Unsaturated; D004338:Drug Combinations; D005231:Fatty Acids, Unsaturated; D008055:Lipids; C045153:Maxepa; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid