title: Localization of the human X-linked gene for chronic granulomatous disease to the mouse X chromosome: implications for X-chromosome evolution.
abstract: The gene encoded at the human X-linked chronic granulomatous disease locus (cytochrome b245 beta subunit) has been mapped to the mouse X chromosome using an interspecific Mus domesticus x M. spretus cross. The localization of this gene provides detailed information on one of the proposed ancestral breakpoints that account for the divergent evolution of the mouse and human X chromosomes.
authors.affiliation: Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Brockdorff
authors.forename: E M
authors.initials: EM
authors.lastname: Fisher
authors.forename: S H
authors.initials: SH
authors.lastname: Orkin
authors.forename: M F
authors.initials: MF
authors.lastname: Lyon
authors.forename: S D
authors.initials: SD
authors.lastname: Brown
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003573:Cytochrome b Group / Q000235:genetics; D015342:DNA Probes; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid; D012729:Sex Chromosome Aberrations / Q000235:genetics; D013045:Species Specificity; D014960:X Chromosome
chemical_list: D003573:Cytochrome b Group; D015342:DNA Probes; C035130:cytochrome b245