The effect of allopurinol on the steady-state pharmacokinetics of indomethacin.
The effect of 5 days treatment with allopurinol (300 mg) on the pharmacokinetics of indomethacin at steady-state was investigated in eight patients. Allopurinol produced no significant effect on the indomethacin serum concentration-time curve. Allopurinol did not alter significantly the amounts of indomethacin excreted in the urine within 8 h. However, the urinary ratio of N-deschlorobenzoylindomethacin to indomethacin was reduced significantly by allopurinol administration (P less than 0.05).
Pullar
T
T
Department of Medicine, University of Leeds.
Myall
O
O
Haigh
J R
JR
Lowe
J R
JR
Dixon
J S
JS
Bird
H A
HA
D000328:Adult; D000493:Allopurinol / Q000494:pharmacology*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000378:metabolism; D001711:Biotransformation; D006801:Humans; D007213:Indomethacin / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy / Q000378:metabolism
D000493:Allopurinol; D007213:Indomethacin