The suitability of some preservatives in chloroquine phosphate syrup.
In Third World countries chloroquine phosphate syrup is frequently prepared with chloroform as a preservative. Because of the toxic side effects of chloroform the suitability of a number of possible alternatives were investigated. If the chloroquine phosphate syrup is prepared as such, the combination of sorbic acid (1.5 g/l) and citric acid (2 g/l) is preferred. If, however, the chloroquine phosphate syrup is prepared from a stock solution of simple syrup, the relatively low pH may be undesirable, because it may negatively affect the stability or solubility of other medicinal compounds. For a stock solution of simple syrup the combination of methyl paraben (1.8 g/l) and propyl paraben (0.2 g/l) is preferred. Good care must be taken that a layer of condense water cannot be formed.
Van Doorne
H
H
Department of Pharmacy, State University of Groningen, The Netherlands.
Wieringa
N F
NF
Bosch
E H
EH
De Meijer
R
R
D000284:Administration, Oral; D000962:Antimalarials / Q000592:standards*; D002738:Chloroquine / Q000031:analogs & derivatives* / Q000592:standards; D003906:Developing Countries; D004355:Drug Stability; D006801:Humans; D010592:Pharmaceutic Aids / Q000592:standards*; D011310:Preservatives, Pharmaceutical / Q000592:standards*
D000962:Antimalarials; D010592:Pharmaceutic Aids; D011310:Preservatives, Pharmaceutical; C023676:chloroquine diphosphate; D002738:Chloroquine