Effect of ambroxol of neutrophil chemotaxis in vitro.
Ambroxol hydrochloride has been shown to protect the lung from damage by polymorphonuclear leucocyte (PMN). In view of this observation we have studied the effect of Ambroxol on PMN chemotaxis using a variety of chemoattractants. The PMN response was inhibited 50-80% by preincubating the cells with concentrations of 10(-4) M Ambroxol. There was no evidence of PMN killing by the drug at concentration of 10(-3) M. The results suggest that Ambroxol my have a role in the management of patients whose chronic lung damage is due to excess PMN recruitment.
Stockley
R A
RA
Lung Immunobiochemical Research Laboratory, General Hospital, Birmingham.
Shaw
J
J
Burnett
D
D
D000551:Ambroxol / Q000494:pharmacology*; D001964:Bromhexine / Q000031:analogs & derivatives*; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects; D015054:Zymosan / Q000494:pharmacology
D000551:Ambroxol; D009240:N-Formylmethionine Leucyl-Phenylalanine; D015054:Zymosan; D001964:Bromhexine