title: Hemodynamic effects of a counterpulsation device implanted on the ascending aorta in severe cardiogenic shock.
abstract: A valveless, single orifice counterpulsation device (CD) with maximum stroke volume of 100 ml was implanted on the ascending aorta of nine dogs. Its pneumatic driver was gaited by the ECG to provide aortic diastolic augmentation, with a stroke volume of 60-70 ml. In the same animals a 20 ml intraaortic balloon (IAB) was placed into the descending aorta. An attempt was made to evaluate the effectiveness of the CD on severe cardiogenic shock and to compare its hemodynamic effects with those of the IABP. Severe cardiogenic shock was induced by coronary artery ligation, propranolol administration, and fluid infusion and was characterized by a LVEDP of 22.2 +/- 6.4 mmHg, ASP less than 70 mmHg and greater than or equal to 30 mmHg, and a reduction of CI by 71.7%. The CD had a significant beneficial effect in all measured parameters. The LVEDP decreased by a mean of 44.3% (P less than 0.001) below control value, and the AEDP by 60.2% (P less than 0.001). The PADA increased by 108.5% (P less than 0.001), and the CI by 155.8% (P less than 0.004). The IABP did not significantly change any of the hemodynamic variables. In conclusion, the CD has significant salutary hemodynamic effects in severe cardiogenic shock where IABP is ineffective.
authors.affiliation: Department of Clinical Therapeutics, University of Athens, Greece.
authors.forename: J N
authors.initials: JN
authors.lastname: Nanas
authors.forename: S N
authors.initials: SN
authors.lastname: Nanas
authors.forename: C E
authors.initials: CE
authors.lastname: Charitos
authors.forename: D
authors.initials: D
authors.lastname: Kontoyiannis
authors.forename: A D
authors.initials: AD
authors.lastname: Poyiadjis
authors.forename: G
authors.initials: G
authors.lastname: Stamatopoulos
authors.forename: A
authors.initials: A
authors.lastname: Melkaoui
authors.forename: G
authors.initials: G
authors.lastname: Kokollis
authors.forename: S D
authors.initials: SD
authors.lastname: Moulopoulos
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000601:surgery*; D001243:Assisted Circulation; D001794:Blood Pressure; D004285:Dogs; D004562:Electrocardiography; D006353:Heart-Assist Devices; D006439:Hemodynamics; D007423:Intra-Aortic Balloon Pumping; D019736:Prostheses and Implants; D012770:Shock, Cardiogenic / Q000628:therapy*