Adrenalectomy fails to stimulate brown adipose tissue metabolism in ob/ob mice fed glucose.
Adrenalectomy arrests the development of obesity in ob/ob mice fed nonpurified high-starch diets partly by stimulating the low thermogenic activity of brown adipose tissue (BAT). However, adrenalectomy fails to suppress the development of obesity in ob/ob mice fed a purified high-glucose diet. Effects of adrenalectomy on BAT metabolism in ob/ob mice fed purified high-starch or high-glucose diets were therefore examined. Adrenalectomy markedly decreased the efficiency of energy retention and increased BAT metabolism (as assessed by GDP binding to BAT mitochondria, GDP-inhibitable acetate- or chloride-induced mitochondrial swelling, and by rates of norepinephrine turnover in BAT) in ob/ob mice fed a high-starch purified diet but had only minimal effects on energy efficiency or BAT metabolism in ob/ob mice fed a high-glucose purified diet. Plasma insulin concentrations decreased and thyroxine concentrations increased in adrenalectomized ob/ob mice fed the high-starch diet; changes in these hormones were less pronounced in adrenalectomized ob/ob mice fed the high-glucose diet. Consumption of glucose mimics effects of adrenal secretions on BAT metabolism in ob/ob mice.
Kim
H K
HK
Department of Food Science and Human Nutrition, Michigan State University, East Lansing 48824-1224.
Romsos
D R
DR
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D004040:Dietary Carbohydrates / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D051379:Mice; D008820:Mice, Obese
D004040:Dietary Carbohydrates; D005947:Glucose