Assignment of human gene encoding testis-specific lactate dehydrogenase C to chromosome 11, region p14.3-p15.5.
The human gene coding for lactate dehydrogenase C (LDHC), a testis-specific isozyme, has been assigned to a refined region of chromosome 11, p14.3-p15.5, in which the lactate dehydrogenase A gene (LDHA) also resides, by using somatic cell hybrids and in situ chromosome hybridization. This assignment clearly indicates the close physical proximity of the LDHC and LDHA genes and supports the evolutionary closeness of these two isozymes.
Kao
F T
FT
Eleanor Roosevelt Institute for Cancer Research, Denver, Colorado 80206.
Wu
K C
KC
Law
M L
ML
Hartz
J A
JA
Lau
Y F
YF
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D015342:DNA Probes; D006801:Humans; D006822:Hybrid Cells; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000235:genetics*
D015342:DNA Probes; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase