title: Allopurinol as an add-on drug in the management of intractable epilepsy.
abstract: The efficacy of allopurinol as an antiepileptic drug has been assessed in a 12 week add-on open uncontrolled study in a small series of 12 patients with intractable epilepsy. Weekly seizure frequencies were observed to be reduced in 4 patients and increased in 5 patients but these changes were not significant and could be attributed to the random variation of seizures.
authors.affiliation: INSEG, Institute of Neurology, National Hospital for Nervous Diseases, Chalfont St. Peter, Bucks, U.K.
authors.forename: J W
authors.initials: JW
authors.lastname: Sander
authors.forename: P N
authors.initials: PN
authors.lastname: Patsalos
mesh_terms: D000328:Adult; D000493:Allopurinol / Q000494:pharmacology*; D000927:Anticonvulsants / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D000927:Anticonvulsants; D000493:Allopurinol