title: Effects of nicardipine on chronic stable effort angina: a non-invasive assessment.
abstract: The effects of 60 mg/day nicardipine hydrochloride were evaluated in a 4-week single-blind study on 12 patients with chronic stable effort angina. All patients completed the treatment with few reports of adverse effects. Nicardipine hydrochloride was effective in reducing the incidence of anginal attacks and consumption of glyceryl trinitrate. Treadmill exercise time, angina onset time and the time to 1 mm ST-segment depression were increased. The extent of ST-segment depression was reduced at maximum comparable exercise, with a reduced rate-pressure product and, at maximum exercise, with an increased rate-pressure product. Myocardial stress 201Tl scintillography was carried out in eight of the patients and showed improved washout in antero-septal, infero-apical and postero-lateral segments. Echocardiographic measures of left ventricular function were enhanced because of reduction of afterload. Systemic vascular resistance and end-systolic stress were also decreased and a significant correlation was found between the increase in ejection fraction and reduction of systolic blood pressure. It is concluded that nicardipine hydrochloride is effective in the control of stable effort angina by reducing myocardial oxygen consumption and enhancing coronary blood flow thereby improving left ventricular function.
authors.affiliation: Department of Cardioangiology, 2nd Medical School, University of Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Galderisi
authors.forename: A
authors.initials: A
authors.lastname: Celentano
authors.forename: G
authors.initials: G
authors.lastname: Mossetti
authors.forename: M
authors.initials: M
authors.lastname: Garofalo
authors.forename: G F
authors.initials: GF
authors.lastname: Mureddu
authors.forename: P
authors.initials: P
authors.lastname: Tammaro
authors.forename: E
authors.initials: E
authors.lastname: Gravina
authors.forename: O
authors.initials: O
authors.lastname: de Divitiis
mesh_terms: D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009529:Nicardipine / Q000627:therapeutic use*; D011877:Radionuclide Imaging; D013794:Thallium Radioisotopes
chemical_list: D013794:Thallium Radioisotopes; D009529:Nicardipine