Androgenic influences on body size and composition of adult rhesus monkeys.
The effects of daily treatment with testosterone propionate (TP, 2 mg/kg) and dihydrotestosterone propionate (DHTP, 2 mg/kg) were examined in rhesus monkeys in three experiments. In experiments 1 and 2, males and females gonadectomized in infancy, and female pseudohermaphrodites produced by prenatal exposure to TP or DHTP and gonadectomized postpubertally, were studied in conjunction with intact males (IM). The IM group was heavier in adulthood than the three gonadectomized groups, which did not differ in body weight from each other. Genetic males had greater crown-rump length than genetic females. Treatment of the gonadectomized groups with TP produced large increases in body mass (averaging approximately 50%) that were attributable to accretion of lean tissue. This effect did not differ significantly between males and females. In experiment 3, additional groups of males that had been castrated as infants were given daily injections with DHTP or oil. The DHTP treatment resulted in increases in body size that were not different from those seen following TP treatment. When TP and DHPT treatments were discontinued, body weights and dimensions reverted to base-line values. Increased body size induced by TP and DHTP was accomplished without reliable increases in food intake. Because testosterone (T) is metabolized to dihydrotestosterone (DHT), while DHT cannot be converted to T, these results show that both T and DHT are effective anabolic hormones in rhesus.
Kemnitz
J W
JW
Wisconsin Regional Primate Research Center, University of Wisconsin-Madison 53715-1299.
Sladky
K K
KK
Flitsch
T J
TJ
Pomerantz
S M
SM
Goy
R W
RW
D000375:Aging; D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D001824:Body Constitution; D001835:Body Weight / Q000187:drug effects; D013196:Dihydrotestosterone / Q000494:pharmacology*; D005260:Female; D008251:Macaca / Q000033:anatomy & histology*; D008253:Macaca mulatta / Q000033:anatomy & histology* / Q000254:growth & development; D008297:Male; D012016:Reference Values; D013739:Testosterone / Q000494:pharmacology*
D013196:Dihydrotestosterone; D013739:Testosterone