Baroreceptor responses derived from a fundamental concept.
A model is presented that relates the change in baroreceptor firing rate to a step change in blood pressure. This relationship is nonlinear since the alteration in rate of firing depends on the current rate of firing. It is shown that this simple relationship embodies all currently established baroreceptor response modes. The model needs refinement to allow for effects arising from the properties of the tissue matrix in which the receptors are embedded. Further analysis is precluded at present owing to paucity of quantitative experimental data.
Taher
M F
MF
Department of Bioengineering, University of Pennsylvania, Philadelphia 19104.
Cecchini
A B
AB
Allen
M A
MA
Gobran
S R
SR
Gorman
R C
RC
Guthrie
B L
BL
Lingenfelter
K A
KA
Rabbany
S Y
SY
Rolchigo
P M
PM
Melbin
J
J
D000818:Animals; D001794:Blood Pressure; D008955:Models, Cardiovascular; D011311:Pressoreceptors / Q000502:physiology*