title: The suitability of some preservatives in chloroquine phosphate syrup.
abstract: In Third World countries chloroquine phosphate syrup is frequently prepared with chloroform as a preservative. Because of the toxic side effects of chloroform the suitability of a number of possible alternatives were investigated. If the chloroquine phosphate syrup is prepared as such, the combination of sorbic acid (1.5 g/l) and citric acid (2 g/l) is preferred. If, however, the chloroquine phosphate syrup is prepared from a stock solution of simple syrup, the relatively low pH may be undesirable, because it may negatively affect the stability or solubility of other medicinal compounds. For a stock solution of simple syrup the combination of methyl paraben (1.8 g/l) and propyl paraben (0.2 g/l) is preferred. Good care must be taken that a layer of condense water cannot be formed.
authors.affiliation: Department of Pharmacy, State University of Groningen, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Van Doorne
authors.forename: N F
authors.initials: NF
authors.lastname: Wieringa
authors.forename: E H
authors.initials: EH
authors.lastname: Bosch
authors.forename: R
authors.initials: R
authors.lastname: De Meijer
mesh_terms: D000284:Administration, Oral; D000962:Antimalarials / Q000592:standards*; D002738:Chloroquine / Q000031:analogs & derivatives* / Q000592:standards; D003906:Developing Countries; D004355:Drug Stability; D006801:Humans; D010592:Pharmaceutic Aids / Q000592:standards*; D011310:Preservatives, Pharmaceutical / Q000592:standards*
chemical_list: D000962:Antimalarials; D010592:Pharmaceutic Aids; D011310:Preservatives, Pharmaceutical; C023676:chloroquine diphosphate; D002738:Chloroquine