title: [Clinico-morphologic and histochemical changes in the neuromuscular apparatus in acute carbophos poisoning].
abstract: Clinical analysis of 378 acute cases of Malathion insecticide intoxication and pathological and histochemical investigation of skeletal muscles in 7 autopsied victims of acute poisoning have revealed the pronounced neuromuscular disorders. Generalized paresis and paralysis of muscles were observed in trunk and limbs. Muscular fasciculation, hypotonia and hyporeflexia were also generalized. Multiple foci of muscular fibers necrosis and necrobiosis were found with intermuscular nerves and motor endings degenerated, neuromuscular junctions cholinesterase sharply inactivated.
authors.forename: I P
authors.initials: IP
authors.lastname: Kolesnichenko
authors.forename: V M
authors.initials: VM
authors.lastname: Buchko
authors.forename: N V
authors.initials: NV
authors.lastname: Vladeeva
mesh_terms: D000061:Accidents, Home; D000208:Acute Disease; D000328:Adult; D000368:Aged; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008294:Malathion / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D009468:Neuromuscular Diseases / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000378:metabolism; D013405:Suicide; D013997:Time Factors
chemical_list: D008294:Malathion
vernacular_title: Kliniko-morfologicheskie i gistokhimicheskie izmeneniia nervno-myshechnogo apparata pri ostrom otravlenii karbofosom.