Ofloxacin compared with ciprofloxacin in the treatment of complicated lower urinary tract infections.
In a double-blind, double-dummy study 61 patients with structural or functional abnormalities of the urinary tract and verified infection were treated for 7 days with ofloxacin 100 mg bd or ciprofloxacin 250 mg bd by mouth. Of 62 isolated strains none was resistant to ofloxacin or ciprofloxacin in vitro. Nineteen patients (63%) in both groups were free from infection ten days after therapy. Clinical resolution of symptoms occurred in 83% in the ofloxacin group and 68% in the ciprofloxacin group. Adverse reactions were reported in four patients (6.5%), two with skin rash, one with gastrointestinal disturbance and one with influenza-like symptoms. This study demonstrates that ofloxacin and ciprofloxacin are effective in the treatment of complicated lower urinary tract infection.
Kromann-Andersen
B
B
Department of Urology, Herlev Hospital, University of Copenhagen, Denmark.
Sommer
P
P
Pers
C
C
Larsen
V
V
Rasmussen
F
F
D002939:Ciprofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D015242:Ofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy*
D002939:Ciprofloxacin; D015242:Ofloxacin