title: The anti-ulcer effect in rats of ginger constituents.
abstract: The effects of ginger, a pungent stomachic natural medicine, on HCl/ethanol-induced gastric lesions in rats, were examined. The orally administered acetone extract at 1000 mg/kg and zingiberene, the main terpenoid from acetone extract, at 100 mg/kg significantly inhibited gastric lesions by 97.5 and 53.6%, respectively. 6-Gingerol, the pungent principle, at 100 mg/kg significantly inhibited gastric lesions by 54.5%. These results suggest that zingiberene, the terpenoid and 6-gingerol are important constituents in stomachic medications containing ginger.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Yamahara
authors.forename: M
authors.initials: M
authors.lastname: Mochizuki
authors.forename: H Q
authors.initials: HQ
authors.lastname: Rong
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: H
authors.initials: H
authors.lastname: Fujimura
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002396:Catechols; D002599:Chalcone / Q000031:analogs & derivatives / Q000627:therapeutic use; D047188:Chalcones; D004224:Diterpenes / Q000627:therapeutic use; D005233:Fatty Alcohols / Q000627:therapeutic use; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000897:Anti-Ulcer Agents; D002396:Catechols; D047188:Chalcones; D004224:Diterpenes; D005233:Fatty Alcohols; D010936:Plant Extracts; C035032:sofalcone; D002599:Chalcone; C007845:gingerol; C031049:geranylgeranylacetone