[Hypertension in pregnant women and beta-blockers. Follow-up of 31 pregnancies].
The authors have conducted a study of 24 women (mean age: 28 years) whose 31 pregnancies were treated with a beta-blocker (propranolol, in most cases). The overall results were compared with data from the literature. The return to normal of the blood pressure (BP) was excellent (23 cases or 74.2%). The BP was poorly controlled in 8 out of 31 cases among which were found the 4 fetal deaths of the study. There was no toxemia, no maternal complications, no theoretical neonatal effect of the beta-blockers (nor bradycardia nor hypoglycaemia). As for fetal hypotrophy, it was more frequent when the ABP did not return to normal (57% hypotrophy vs 39%) and the beta-blocker, by causing a return to normal of the BP, decreases its incidence. In addition, the mean length of treatment exceeded 2.35 weeks in normotrophic newborns in comparison with the hypotrophic newborns. Concomitantly, the return to normal of the blood pressure is improved in normotrophic newborns. The risk of fetal hypotrophy attributed to the beta-blockers is therefore confirmed and these drugs even have a favorable effect on the birth weight.
Norès
J M
JM
Service de Médecine Interne, Hôpital Raymond-Poincaré, Garches.
Lignières
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G
Tcherdakoff
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P
D000328:Adult; D001794:Blood Pressure; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007674:Kidney Diseases / Q000503:physiopathology; D007743:Labor, Obstetric; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011433:Propranolol / Q000627:therapeutic use*
D011433:Propranolol
Hypertension de la femme enceinte et bêtabloquants. Suivi de 31 grossesses.