[Antiparasitic activity of Cis-Pt (II) pentamidine in experimental trypanosomiasis of sheep caused by Trypanosoma brucei brucei].
The failure of trypanocidal therapeutics have made it a duty to use other classes of molecules which show a comparable trypanocidal efficacy with well-known medicines. In this study, the authors have evaluated the trypanocidal activity of a Cis-Platinum (II) salt, DNA-intercalating medicine used in antineoplastic therapeutics, associated with pentamidine: Cis-Pt (II) pentamidine. After primary screenings on a murine model of T. brucei brucei, Cis-Pt (II) pentamidine was evaluated on an experimental sheep trypanosomiasis model, standardized by the Institute of Neurological Epidemiology and Tropical Neurology of Limoges (France). Cis-Pt (II) pentamidine was able to cure infected mice, without relapse, after a single subcutaneous injection of 12.5 mg.kg-1 body weight. In sheep trypanosomiasis, the same treatment was used successfully during the first stage of infection. Neurological stage susceptibility and pharmacokinetics in sheep will be evaluated in a further study.
Dreyfuss
G
G
Laboratoire de Parasitologie, Faculté de Médecine de Limoges.
Gayral
P
P
Dubost
G
G
Nicolas
J A
JA
Craciunescu
D
D
D000578:Amidines; D000818:Animals; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D010419:Pentamidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012756:Sheep; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014346:Trypanosoma brucei brucei; D014353:Trypanosomiasis, African / Q000188:drug therapy*
D000578:Amidines; D009944:Organoplatinum Compounds; D014344:Trypanocidal Agents; C057919:platinum(II) pentamidine; D010419:Pentamidine
Activité antiparasitaire du Cis-Pt (II) pentamidine dans la trypanosomose expérimentale du mouton à Trypanosoma brucei brucei.