title: [Analysis of the possible mechanisms for the persistence of the vaccinal strain of the measles virus in a human cell culture].
abstract: The mechanisms (factors) of the measles virus vaccine L-16 strain persistence in HEp-2 cell culture were analysed. Among the known mechanisms, most likely is the reduction of the cell-destroying properties of the persisting virus due to mutations in nucleoprotein gene manifested by changes of the isoelectric point of NP protein and temperature sensitivity of its synthesis.
authors.forename: O G
authors.initials: OG
authors.lastname: Andzhaparidze
authors.forename: N N
authors.initials: NN
authors.lastname: Bogomolova
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Boriskin
authors.forename: I B
authors.initials: IB
authors.lastname: Koptiaeva
authors.forename: N M
authors.initials: NM
authors.lastname: Chaplygina
mesh_terms: D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D003673:Defective Viruses / Q000032:analysis / Q000502:physiology; D006801:Humans; D008459:Measles virus / Q000032:analysis / Q000502:physiology*; D009154:Mutation; D013997:Time Factors; D014762:Viral Interference; D014764:Viral Proteins / Q000032:analysis; D014776:Virus Cultivation
chemical_list: D014764:Viral Proteins
vernacular_title: Analiz vozmozhnykh mekhanizmov persistentsii vaktsinnogo shtamma virusa kori v kul'ture kletok cheloveka.