Proliferation of alveolar macrophages in hyperoxia.
The effect of oxygen on the proliferative response of alveolar macrophages (AMs) was investigated. Alveolar macrophages cultured in hyperoxic atmosphere (95% O2 + 5% CO2) for 18 hours showed increased incorporation of [3H]-thymidine and proliferation in contrast to those cultured in a control atmosphere (95% air + 5% CO2). The proliferating cell was shown to be a macrophage by morphology, esterase staining, and phagocytic ability. The results suggest an oxygen-induced proliferation of AMs that may play a critical role in AM influx into the alveoli particularly at times of hyperoxia, eg, the neonatal period.
Nerurkar
L S
LS
Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20007.
Zeligs
B J
BJ
Bellanti
J A
JA
D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D008264:Macrophages / Q000473:pathology*; D010100:Oxygen / Q000097:blood* / Q000502:physiology; D011650:Pulmonary Alveoli / Q000166:cytology*; D011817:Rabbits
D010100:Oxygen