title: Objective criteria for in-vitro responses in human tumor colony-forming assays.
abstract: The application of rigorous statistical criteria to the design and analysis of in-vitro assay techniques can lead to more reliable assessments of their utility. The authors demonstrate that an objective criterion for in-vitro drug sensitivity would yield less pronounced false-negative error rates than a fixed-cutoff rule, and would therefore be more suitable for screening of putative chemotherapeutic agents.
authors.affiliation: Department of Basic and Clinical Research, Scripps Clinic and Research Foundation, La Jolla, California 92037.
authors.forename: J A
authors.initials: JA
authors.lastname: Koziol
authors.forename: A J
authors.initials: AJ
authors.lastname: Petkau
authors.forename: R
authors.initials: R
authors.lastname: Taetle
mesh_terms: D003114:Colony-Forming Units Assay; D003662:Decision Theory; D004305:Dose-Response Relationship, Drug; D005188:False Negative Reactions; D006801:Humans; D015233:Models, Statistical; D011237:Predictive Value of Tests; D011336:Probability; D014410:Tumor Stem Cell Assay