title: [Metabolism of the anticonvulsant preparation Benzonal in the human body].
abstract: One of the metabolites of the anticonvulsant drug Benzonal (BZL) has been isolated and its chemical structure studied. High-performance liquid chromatography (HPLC) was utilized for isolation of the metabolite from the blood plasma in patients after a single oral BZL dose of 100 mg. Using this technique and ultraviolet, infrared and mass spectrometries BZL was found to be partially metabolized into phenobarbital by human organism.
authors.forename: V M
authors.initials: VM
authors.lastname: Okudzhava
authors.forename: B G
authors.initials: BG
authors.lastname: Chankvetadze
authors.forename: M M
authors.initials: MM
authors.lastname: Rogava
authors.forename: M D
authors.initials: MD
authors.lastname: Rukhadze
mesh_terms: D000927:Anticonvulsants / Q000097:blood / Q000493:pharmacokinetics*; D001463:Barbiturates / Q000097:blood / Q000493:pharmacokinetics*; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy; D006801:Humans; D006868:Hydrolysis; D010634:Phenobarbital / Q000097:blood
chemical_list: D000927:Anticonvulsants; D001463:Barbiturates; C002915:benzobarbital; D010634:Phenobarbital
vernacular_title: O metabolizme protivosudorozhnogo preparata benzonala v organizme cheloveka.