Trisomy and tetrasomy of the long arm of chromosome 1 in a direct preparation of human endometrial adenocarcinoma.
Chromosome banding analysis was performed on an endometrial adenocarcinoma. A minimal variety in the chromosome number and morphology was found. All analyzed pseudodiploid and aneuploid carcinoma cells had two chromosomes 1 of normal morphology and the presence of a marker or markers derived from chromosome 1. Tetrasomy of the long arm of chromosome 1 was found in 12 of 19 cells analyzed, accompanied by trisomy of the long arm of chromosome 1 in the rest of the cells. No other common chromosome marker was observed. Previously published data and our results suggest that trisomy and tetrasomy of the long arm of chromosome 1 may represent a specific karyotypic change in subtypes of endometrial adenocarcinoma.
Horgas
G
G
Department of Nuclear Medicine and Oncology, Clinical Hospital Dr. Mladen Stojanović, Zagreb, Yugoslavia.
Grubisić
G
G
Spaventi
S
S
D000230:Adenocarcinoma / Q000235:genetics*; D000368:Aged; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D005260:Female; D006801:Humans; D007621:Karyotyping; D011003:Ploidies; D014314:Trisomy; D014594:Uterine Neoplasms / Q000235:genetics*