title: The effect of detomidine (Domosedan) on the maintenance of equine pregnancy and foetal development: ten cases.
abstract: Detomidine was administered throughout 10 pregnancies in eight mares. An intravenous injection of 20 micrograms/kg body weight was given weekly from Day 14 to Day 60 of gestation and thereafter every four weeks until parturition. One mare suffered torsion of the large colon and was destroyed on Day 86; the foetus was normally developed. A further mare aborted at 167 days. The remaining eight pregnancies continued to full term. One foal was delivered by caesarean section because of torticollis and, of the seven foals born spontaneously, one had bilateral upward patellar fixation at one month old. Therefore, although only six of the 10 foals developed normally, the other four cases showed no pathological similarities to suggest a common cause. Although these data were based on a small number of mares, they did not suggest that the repeated administration of detomidine had specific adverse effects on the pregnancies.
authors.affiliation: Department of Obstetrics and Gynaecology, College of Veterinary Medicine, Hautjarvi, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Katila
authors.forename: M
authors.initials: M
authors.lastname: Oijala
mesh_terms: D000818:Animals; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D006736:Horses / Q000502:physiology*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*
chemical_list: D006993:Hypnotics and Sedatives; D007093:Imidazoles; C041255:detomidine