Further comparison of adjuvants for an inactivated infectious coryza vaccine.
Inactivated infectious coryza vaccines containing different adjuvants were administered to 6-week-old chickens as a single dose containing 10(8) colony-forming units of Haemophilus paragallinarum HP31. After 3 weeks, all chickens were challenged by intrasinus inoculation of HP31. Two vaccines, one containing an aluminum-hydroxide adjuvant and the other a combined aluminum-hydroxide + avridine (a lipoidal amine) adjuvant, were effective. The three remaining vaccines--containing mineral-oil double-emulsion, avridine, or a combination of mineral-oil double-emulsion + avridine--gave much lower levels of protection. No adverse reactions were seen with any vaccine.
Blackall
P J
PJ
Animal Research Institute, Yeerongpilly, Australia.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000536:Aluminum Hydroxide / Q000627:therapeutic use; D000818:Animals; D002645:Chickens; D003959:Diamines / Q000627:therapeutic use; D006192:Haemophilus Infections / Q000517:prevention & control / Q000662:veterinary*; D008899:Mineral Oil / Q000627:therapeutic use; D011201:Poultry Diseases / Q000382:microbiology / Q000517:prevention & control*; D015164:Vaccines, Inactivated / Q000627:therapeutic use*; D014765:Viral Vaccines / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D003959:Diamines; D015164:Vaccines, Inactivated; D014765:Viral Vaccines; D000536:Aluminum Hydroxide; D008899:Mineral Oil; C006270:avridine