Phenotypes of apolipoprotein E and abnormalities in lipid metabolism in patients with non-insulin-dependent diabetes mellitus.
Phenotypic expressions of apolipoprotein E (apo E) were studied in 94 Japanese patients with non-insulin-dependent diabetes mellitus (NIDDM) and in 91 normal controls. The apo E gene frequencies observed in patients with NIDDM (epsilon 4, 0.101; epsilon 3, 0.824; and epsilon 2, 0.075) were not significantly different from those in normal controls (epsilon 4, 0.093; epsilon 3, 0.863; and epsilon 2, 0.044). Subgrouping the diabetic patients with and without hyperlipidemia, the epsilon 2 allele was significantly more frequent in patients with hypertriglyceridemia. The levels of serum triglyceride, very low density lipoprotein-cholesterol (VLDL-C), and VLDL-triglyceride (VLDL-TG) were significantly higher in patients with the epsilon 2 heterozygote than in those without the epsilon 2 allele (P less than .01). The results suggest that variation in the apo E gene may be one factor related to the hypertriglyceridemia present in patients with NIDDM.
Imari
Y
Y
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Koga
S
S
Ibayashi
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D014280:Triglycerides / Q000097:blood
D001057:Apolipoproteins E; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C030106:very low density lipoprotein triglyceride