title: Non-random chromosomal aberrations in a complex leukaemic clone of a Bloom's syndrome patient.
abstract: Bloom's syndrome is one of the congenital disorders known to have increased frequency of acute leukaemia. The complex cytogenetic findings in the leukaemic cells of a 39-year-old male with Bloom's syndrome are described. These included a translocation t(7;17), missing 7q and 17p, a reciprocal translocation t(4;22); del 3q, del 8q22, del 20q, missing 12 and missing Y. In the same patient a missing Y had been noted 10 years previously in 15% of his peripheral blood lymphocytes.
authors.affiliation: Gattegno Research Institute for Human Reproduction and Fetal Development, Hasharon Hospital, Golda Medical Center, Tel Aviv University Medical School, Petah-Tiqva, Israel.
authors.forename: F
authors.initials: F
authors.lastname: Shabtai
authors.forename: U H
authors.initials: UH
authors.lastname: Lewinski
authors.forename: A
authors.initials: A
authors.lastname: Meroz
authors.forename: D
authors.initials: D
authors.lastname: Klar
authors.forename: M
authors.initials: M
authors.lastname: Djaldetti
authors.forename: I
authors.initials: I
authors.lastname: Halbrecht
mesh_terms: D000208:Acute Disease; D000328:Adult; D001816:Bloom Syndrome / Q000150:complications / Q000235:genetics*; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002873:Chromosome Fragility; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000209:etiology / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic