The effect of a diet rich in brussels sprouts on warfarin pharmacokinetics.
Ten healthy subjects were given 20 mg of warfarin orally before, and after a daily intake of 400 g of brussels sprouts for 2 weeks. The brussels sprouts diet stimulated warfarin disposal as evidenced by a 29% increase in mean elimination rate constant, accompanied by a 27% increase in metabolic clearance rate and a 16% decrease in plasma AUC. It is concluded that a high intake of brussels sprouts, a cruciferous vegetable, accelerates warfarin disposal, and thereby might contribute to less anticoagulation.
Ovesen
L
L
Nutrition Laboratory, Kommunehospitalet, Copenhagen, Denmark.
Lyduch
S
S
Idorn
M L
ML
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D014675:Vegetables; D014859:Warfarin / Q000493:pharmacokinetics* / Q000494:pharmacology
D014859:Warfarin