Local tolerance of muroctasin injection in rabbits.
The local tolerance of N2-[(N-acetylmuramoyl)- N2-[(N-acetylmuramoyl)-L-alanyl-D-isoglutaminyl]-N6-stearoyl-L-lysine (MDP-Lys (L18), muroctasin), a synthetic muramyl dipeptide derivative, was investigated in rabbits. One ml of MDP-Lys (L18) injection was administered into the dorsal subcutis in single dose or multiple doses. Pathological examination revealed moderate infiltration of inflammatory cells at the injection sites 2 days after the last injection, but there was a tendency for recovery from this change to occur by the 7th day after injection. In conclusion, the tissue lesion caused by MDP-Lys (L18) injection administered subcutaneously is slight and transient.
Nakashima
K
K
Research Institute, Daiichi Seiyaku Co., Ltd., Tokyo, Japan.
Jindo
T
T
Nomura
M
M
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D004361:Drug Tolerance; D007279:Injections, Subcutaneous; D008297:Male; D011817:Rabbits; D012867:Skin / Q000187:drug effects* / Q000473:pathology
D000276:Adjuvants, Immunologic; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C036866:romurtide