Metabolism of 2,6-dichlorobenzamide in rats and mice.
1. Oral doses of 2,6-dichlorobenzamide (DCB) were excreted by rats as DCB, two monohydroxy-DCBs, 2-chloro-5-hydroxy-6-(methylthio)benzamide and 2-chloro-5-hydroxy-6-[S-(N-acetyl)cysteinyl]benzamide (mercapturic acid). 2. Biliary excretion (33% of the dose), enterohepatic circulation and intestinal micro-floral metabolism were involved in formation of 2-chloro-5-hydroxy-6-(methylthio)benzamide, and the mercapturic acid served as a precursor. 3. Whole body autoradiography and microautoradiography showed the accumulation of non-extractable residues from DCB in the nasal mucosa and contents of the large intestines of rats and mice dosed with 14C-labelled DCB.
Bakke
J E
JE
Metabolism and Radiation Research Laboratory, U.S. Department of Agriculture, Fargo, ND 58105.
Larsen
G L
GL
Feil
V J
VJ
Brittebo
E B
EB
Brandt
I
I
D000818:Animals; D001345:Autoradiography; D001549:Benzamides / Q000378:metabolism / Q000493:pharmacokinetics*; D001646:Bile / Q000378:metabolism; D002250:Carbon Radioisotopes; D004764:Enterohepatic Circulation; D005243:Feces; D005260:Female; D007408:Intestinal Absorption; D007420:Intestine, Large / Q000378:metabolism; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D009297:Nasal Mucosa / Q000378:metabolism; D009570:Nitriles; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D001549:Benzamides; D002250:Carbon Radioisotopes; D009570:Nitriles; C055869:dichlobanil