title: Effect of acute medical reduction of intraocular pressure on the visual field and optic disc in ocular hypertension.
abstract: The effect of acute reduction of intraocular pressure (IOP) through oral administration of glycerol was assessed in 15 eyes of 15 patients with ocular hypertension by means of automated perimetry, Farnsworth-Munsell 100 hue testing, measurement of spatial contrast sensitivity with a laser interferometer and automated optic disc analysis. There was no significant relation between the absolute or relative change in IOP and the corresponding changes in any of the visual field or optic disc indices studied. The colour vision score increased significantly as the IOP decreased (p = 0.03). There was a significant reduction in the logarithm of spatial contrast sensitivity at grating sizes of 3 (p = 0.007) and 7.5 (p = 0.05) cycles per degree as the IOP decreased.
authors.affiliation: Department of Ophthalmology, University of British Columbia, Vancouver.
authors.forename: A C
authors.initials: AC
authors.lastname: Farinelli
authors.forename: F S
authors.initials: FS
authors.lastname: Mikelberg
authors.forename: S M
authors.initials: SM
authors.lastname: Drance
authors.forename: G R
authors.initials: GR
authors.lastname: Douglas
authors.forename: M
authors.initials: M
authors.lastname: Schulzer
authors.forename: K
authors.initials: K
authors.lastname: Wijsman
mesh_terms: D000328:Adult; D000368:Aged; D003118:Color Perception / Q000187:drug effects; D015350:Contrast Sensitivity; D005260:Female; D005990:Glycerol / Q000627:therapeutic use*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D009898:Optic Disk / Q000473:pathology*; D014794:Visual Fields / Q000187:drug effects*
chemical_list: D005990:Glycerol