Influence of alcohol pretreatment on effects of chloroform in rats.
Methanol, ethanol and isopropanol were tested for the ability to change effects of chlorinated hydrocarbons on the alanine aminotransferase (ALAT = GPT; EC 2.6.1.2.) activity in serum of rats. The alcohols were given once orally or repeatedly together with drinking water. After additional i.p. administration of chloroform we found a significant increase of ALAT activities in the order: isopropanol greater than or equal to methanol greater than ethanol, both after single and repeated application of the alcohols. Together with trichloroethene and 1.1.2.2-tetrachloroethane no such elevations were found. The results suggest that different mechanisms of action could be underlying.
Kniepert
E
E
Department of Medicine, Karl-Marx University, Leipzig, GDR.
Görisch
V
V
D000433:1-Propanol / Q000494:pharmacology*; D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002725:Chloroform / Q000633:toxicity*; D004327:Drinking Behavior / Q000187:drug effects; D004357:Drug Synergism; D002149:Energy Intake / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D000432:Methanol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol; D002725:Chloroform; D000433:1-Propanol; D000410:Alanine Transaminase; D000432:Methanol