9.4 T imaging studies of human tumor xenografts in nude mice.
To evaluate the potential of 9.4 T imaging in distinguishing normal and neoplastic tissues, we examined the progressive growth of human colon and prostate adenocarcinoma xenografts in nude mice. Images were obtained with a resolution of 100 X 100 X 650 micron, and tumors were clearly distinguished from normal tissue with high contrast. These results demonstrate the feasibility of detecting small human tumors in live nude mice with microscopic resolution at 9.4 T.
Sarkar
S K
SK
Smith Kline & French Laboratories, King of Prussia, Pennsylvania 19406-0939.
Mattingly
M A
MA
Kline
T
T
Greig
R
R
D000230:Adenocarcinoma / Q000175:diagnosis*; D000818:Animals; D003110:Colonic Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D014183:Transplantation, Heterologous