Carcinogenicity studies of masheri, a pyrolysed product of tobacco.
The carcinogenicity of two commonly used brown and black varieties of masheri, a pyrolysed tobacco product, was studied by feeding the masheri through the diet at a 10% level to three different animal species of both sexes. In Sprague-Dawley rats, only brown masheri was used, while in Swiss mice and Syrian golden hamsters both varieties were used. In all the three species, forestomach papillomas were induced as a result of masheri treatment. In rats, 37% of animals showed forestomach papillomas while in mice and hamsters the incidence was 42-47% and 25-43%, respectively. No malignant changes were observed in any of the groups except 2/23 male hamsters showed forestomach carcinoma in the black masheri diet group.
Kulkarni
J R
JR
Carcinogenesis Division, Cancer Research Institute, Tata Memorial Centre, Bombay, India.
Lalitha
V S
VS
Bhide
S V
SV
D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens; D006224:Cricetinae; D003802:Dentifrices; D008175:Lung Neoplasms / Q000139:chemically induced; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010212:Papilloma / Q000139:chemically induced; D010936:Plant Extracts / Q000633:toxicity*; D010947:Plants, Toxic; D013274:Stomach Neoplasms / Q000139:chemically induced; D014026:Nicotiana
D002273:Carcinogens; D003802:Dentifrices; D010936:Plant Extracts; C057607:masheri