title: Pedigree analysis of HDL cholesterol concentration in baboons on two diets.
abstract: Using complex segregation analysis, we examined the effects of genetic factors and diet on serum concentrations of high-density-lipoprotein cholesterol (HDL-C) in baboons. In analyses of 710 baboons in 23 sire families, we found evidence for a major gene as well as a polygenic contribution to HDL-C concentration in baboons fed a basal (chow) diet and also in the same animals after challenge with a high-cholesterol, saturated-fat diet. There was evidence for a polygenic contribution to the change in HDL-C concentration in response to the dietary challenge, but there was no evidence for a major gene effect.
authors.affiliation: Southwest Foundation for Biomedical Research, San Antonio, TX 78284.
authors.forename: J W
authors.initials: JW
authors.lastname: MacCluer
authors.forename: C M
authors.initials: CM
authors.lastname: Kammerer
authors.forename: J
authors.initials: J
authors.lastname: Blangero
authors.forename: B
authors.initials: B
authors.lastname: Dyke
authors.forename: G E
authors.initials: GE
authors.lastname: Mott
authors.forename: J L
authors.initials: JL
authors.lastname: VandeBerg
authors.forename: H C
authors.initials: HC
authors.lastname: McGill
mesh_terms: D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics*; D004036:Diet, Atherogenic; D005260:Female; D014644:Genetic Variation; D008297:Male; D008957:Models, Genetic; D010215:Papio / Q000097:blood / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype
chemical_list: D008076:Cholesterol, HDL