Trisomy 5 as sole anomaly in acute lymphoblastic leukemia.
We present a case of B-cell acute lymphoblastic leukemia (ALL) in whose leukemic cells trisomy 5 (+5) was the only cytogenetic anomaly observed. This is the first report of +5 as the sole cytogenetic abnormality in ALL; two cases (one questionable) of acute nonlymphocytic leukemia with such a change have been reported. The findings are presented in relation to other cases with +5 as part of a more complicated cytogenetic picture in hematologic disorders.
Sandberg
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Cancer Center of Southwest Biomedical Research Institute, Scottsdale, AZ 85251.
Morgan
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Morgan
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Boros
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D000328:Adult; D002051:Burkitt Lymphoma / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007621:Karyotyping; D008297:Male; D014314:Trisomy