Fast atom bombardment mass spectrometry of some anthracycline and bisanthracycline derivatives.
Fast atom bombardment (FAB) mass spectra of daunomycin, four of its derivatives, seven bisanthracyclines and three mixed-functional daunomycin-acridine derivatives are reported. These anthracyclines all exhibited their expected [MH]+ ions and peaks corresponding to the fragmentations which are characteristic of the anthracycline moiety, and in addition the spectra showed enhanced [MH + n]+ (n = 1-4) ions which were attributed to reductive processes occurring in the liquid matrix under FAB conditions. Daunomycin was also observed to form a dimeric cluster ion [M2H]+ together with associated reduced ions under FAB conditions. We have found that FAB mass spectrometry is an ideal method for the qualitative analysis of large, non-volatile derivatives of anthracyclines.
Chandler
C J
CJ
Department of Chemistry, La Trobe University, Bundoora, Victoria, Australia.
Brownlee
R T
RT
Hook
R J
RJ
Phillips
D R
DR
Reiss
J A
JA
Edgar
J A
JA
D000903:Antibiotics, Antineoplastic / Q000032:analysis*; D003630:Daunorubicin / Q000032:analysis; D004317:Doxorubicin / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D013058:Mass Spectrometry
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; D003630:Daunorubicin