title: The utilization of monoclonal antibodies in the diagnosis of unusual leukemias.
abstract: Development of monoclonal antibodies to lymphoid cells has allowed for simple methods for the classification of leukemias. Using the monoclonal antibodies, B1, B4, T1, T11, Ia, CALLA, My7, My9, and a polyclonal TdT reagent, we report a number of unusual phenotypes analyzed by flow cytometry. Two cases of mixed linkage leukemia are reported, one marked with anti-CALLA and My9, the other marked with T11 and Ia. Three rare cases of pediatric CLL are reported. Both were of B cell origin with chromosome transformation. These studies demonstrate the clinical importance of monoclonal antibodies in leukemia classification. The results also show that the so-called rare leukemias may not be as rare as previously thought.
authors.affiliation: Department of Microbiology and Immunology, Texas College of Osteopathic Medicine, Fort Worth 76107.
authors.forename: J W
authors.initials: JW
authors.lastname: Measel
authors.forename: K A
authors.initials: KA
authors.lastname: Ferguson
authors.forename: A
authors.initials: A
authors.lastname: Distefano
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D007938:Leukemia / Q000145:classification / Q000175:diagnosis*; D008297:Male; D010641:Phenotype
chemical_list: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor