Evidence for potentiation of lipid peroxidation in the rat liver after chronic ethanol feeding.
Hepatic steatosis was induced in rats by feeding nutritionally adequate liquid diet containing ethanol as 36% of energy for 4-5 weeks. After 24 h fasting and withdrawal from ethanol, liver ischaemia for 30 min followed by 2 h reperfusion resulted in a significant increase in microsomal lipid peroxide content and a decrease in reduced glutathione content as well as in protein synthesis with a rapid accumulation of triglyceride in the liver. In rats fed a non-ethanol diet or those fed a high-cholesterol diet with hepatic steatosis, however, similar phenomena were not found. These findings suggest that chronic ethanol feeding potentiates hepatic lipid peroxidation.
Yamada
S
S
First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Fujiwara
K
K
Masaki
N
N
Ohta
Y
Y
Sato
Y
Y
Oka
H
H
D000818:Animals; D000431:Ethanol / Q000008:administration & dosage*; D007511:Ischemia; D050356:Lipid Metabolism; D008099:Liver / Q000473:pathology; D008102:Liver Circulation / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol