title: [Cellular modification during acquisition of drug-resistance to anticancer agents].
abstract: In this article, we describe plausible mechanisms for drug-resistance of tumor cells to anticancer agents and also cellular modification associated with drug-resistance including heterogenous population of tumor cells, altered response to growth factor, and tumorigenicity of drug-resistant.
authors.affiliation: Dept. of Biochemistry, Oita Medical School.
authors.forename: K
authors.initials: K
authors.lastname: Kohno
authors.forename: J
authors.initials: J
authors.lastname: Kikuchi
authors.forename: M
authors.initials: M
authors.lastname: Kuwano
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D004351:Drug Resistance; D066246:ErbB Receptors / Q000032:analysis; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D066246:ErbB Receptors