Islet amyloid polypeptide: identification and chromosomal localization of the human gene.
Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from pancreatic amyloid. Here, we describe the isolation and partial characterization of the human gene encoding IAPP. The DNA sequence predicts that IAPP is excised from a larger precursor protein and that its carboxy-terminus is probably amidated. The predicted normally occurring IAPP is identical to the reported polypeptides isolated from pancreatic amyloid, except for the amidated carboxy-terminus. IAPP specific polyadenylated RNAs of 1.6 kb and 2.1 kb are present in human insulinoma RNA. The human IAPP gene is located on chromosome 12.
Mosselman
S
S
Institute of Molecular Biology, University of Utrecht, The Netherlands.
Höppener
J W
JW
Zandberg
J
J
van Mansfeld
A D
AD
Geurts van Kessel
A H
AH
Lips
C J
CJ
Jansz
H S
HS
D000595:Amino Acid Sequence; D000682:Amyloid / Q000235:genetics*; D001483:Base Sequence; D015152:Blotting, Northern; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D005796:Genes; D006801:Humans; D058228:Islet Amyloid Polypeptide; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization
D000682:Amyloid; D058228:Islet Amyloid Polypeptide