Pharmacokinetics of cysteine ethyl ester in rat.
1. The pharmacokinetics of the mucolytic compound 35S-cysteine ethyl ester in rat show that it is completely absorbed after oral administration, with a bioavailability of 0.59. 2. By autoradiography, tissue distribution of 35S-cysteine ethyl ester showed a high affinity for the lung, different to that observed with 35S-cysteine. 3. Unchanged cysteine ethyl ester, cysteine and inorganic sulphates were present in the lung. 4. After oral or i.v. administration of 35S-cysteine ethyl ester the total radioactivity excreted in the urine amounted to 16% dose and 40% was excreted in the faeces, following biliary excretion. It was metabolized to inorganic sulphate, cysteine and taurine, which were excreted in the urine.
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INSERM S.C. No. 26, hospital Saint Antoine, Paris, France.
Goulinet
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Renault
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D000042:Absorption; D000818:Animals; D001345:Autoradiography; D001682:Biological Availability; D002855:Chromatography, Thin Layer; D003545:Cysteine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D007668:Kidney / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D051381:Rats; D013462:Sulfur Radioisotopes; D014018:Tissue Distribution
D013462:Sulfur Radioisotopes; C031752:ethyl cysteine; D003545:Cysteine