title: Comparing mean levels of total cholesterol from visit 2 of the Lipid Research Clinics Prevalence Study with the second National Health and Nutrition Examination Survey.
abstract: Mean levels of total cholesterol by sex and age were compared between groups of whites in visit 2 of the Lipid Research Clinics Program Prevalence Study and in the second National Health and Nutrition Examination Survey (NHANES II). NHANES II estimates were found to be higher than comparable visit 2 estimates by 3-14 mg/dl for males and by 11-21 mg/dl for females. Adjustment for the use of differing components of blood in making the lipid determinations in the two studies (plasma in visit 2 and serum in NHANES II) reduced the original differences by roughly one half. Other adjustments--for operational differences among laboratories that performed the blood sample analysis in the two studies, for educational differences in the study populations, and for inclusion of data from a Toronto clinic in the visit 2 data--were collectively found to explain most of the remaining differences between visit 2 and NHANES II, especially for males.
authors.affiliation: Department of Biostatistics, University of North Carolina, Chapel Hill.
authors.forename: W D
authors.initials: WD
authors.lastname: Kalsbeek
authors.forename: K M
authors.initials: KM
authors.lastname: Kral
authors.forename: R B
authors.initials: RB
authors.lastname: Wallace
authors.forename: B M
authors.initials: BM
authors.lastname: Rifkind
mesh_terms: D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood*; D004812:Epidemiologic Methods; D005260:Female; D006306:Health Surveys; D006728:Hormones / Q000008:administration & dosage; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000032:analysis; D011786:Quality Control; D011897:Random Allocation; D012107:Research Design; D012621:Seasons; D012737:Sex Factors; D014481:United States
chemical_list: D006728:Hormones; D008055:Lipids; D002784:Cholesterol