Tumor and tissue distribution of 125I-labeled natural and antitumor antibodies in murine experimental tumor systems.
The binding and tissue distribution of 125I-labeled rabbit anti-sarcoma 180 (S-180) immunoglobulin G (IgG) (RAS-180G), normal rabbit IgG (NRG) and ICR mouse IgGs from normal (NMG) and S-180-bearing ICR mice (AS-180G) were studied in ICR mice bearing S-180. 125I-labelled IgGs preparted from normal (NC57G) or Adenocarconoma 755 (Ca 755)-bearing C57BL/6 mice (A755G) were also examined in C57BL/6 mice bearing ca755. Not only RAS-180G and AS-180G but also NRG and NMG persisted in the tumor site. This result suggests that allogeneic natural IgG could be used as a carrier protein for antitumor agents.
Niimura
K
K
Biomedical Research Laboratories, Kureha Chemical Industry, Co., Ltd., Tokyo, Japan.
Furusho
T
T
Fujii
M
M
Oguchi
Y
Y
Fujii
T
T
Takahashi
N
N
Matsunaga
K
K
Sugita
N
N
Yoshikumi
C
C
Kawai
Y
Y
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000276:immunology*; D000818:Animals; D007074:Immunoglobulin G / Q000378:metabolism*; D007457:Iodine Radioisotopes; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D011877:Radionuclide Imaging; D012510:Sarcoma 180 / Q000000981:diagnostic imaging / Q000276:immunology*; D014018:Tissue Distribution
D007074:Immunoglobulin G; D007457:Iodine Radioisotopes