Clinical response and total and unbound plasma concentrations after lidocaine overdose.
Plasma and unbound concentrations and hemodynamic and CNS effects were monitored in a patient after overdose of 2 g of lidocaine HCl infused during 1 h. Hypotension, decreased heart rate, tremors, and nonresponsiveness to stimuli were observed at plasma and unbound concentrations of 17.7 and 12.0 micrograms/ml. The half-lives of decline of plasma and unbound concentrations were 3.8 and 2.7 h; the difference in half-lives was due to nonlinear plasma protein binding.
Armstrong
D K
DK
Laboratory of Applied Pharmacokinetics, University of Southern California School of Medicine, Los Angeles.
Bremseth
D L
DL
Lima
J J
JJ
D000368:Aged; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007118:Immunoassay; D008012:Lidocaine / Q000097:blood* / Q000506:poisoning; D008297:Male; D014202:Tremor / Q000139:chemically induced
D008012:Lidocaine