Synthetic ferrichrome analogues with growth promotion activity for Arthrobacter flavescens.
Two families of trihydroxamic acid analogues of ferrichrome were chemically synthesized and tested for biological activity with Arthrobacter flavescens. Compounds using a tertiary amine as anchor showed little activity. Several compounds using tetrahedral carbon as anchor showed activity approaching or equalling that of the natural siderophore, ferrichrome. The biological activity is discussed in relation to physical and chemical properties of the analogues.
Shanzer
A
A
Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel.
Libman
J
J
Lazar
R
R
Tor
Y
Y
Emery
T
T
D001173:Arthrobacter / Q000187:drug effects* / Q000254:growth & development; D005291:Ferrichrome / Q000494:pharmacology*; D006133:Growth Substances; D006877:Hydroxamic Acids / Q000494:pharmacology*; D008024:Ligands; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
D006133:Growth Substances; D006877:Hydroxamic Acids; D008024:Ligands; D005291:Ferrichrome