title: AA amyloidosis associated with systemic lupus erythematosus.
abstract: A 54-year-old female with a 23-year history of systemic lupus erythematosus was admitted because of loss of renal function and nephrotic syndrome. Renal biopsy showed deposition of AA amyloid as demonstrated by Congo red staining and reactivity with protein AA-specific antibodies. Immune deposits were present in the mesangium and the glomerular basement membrane, but histopathological changes consistent with lupus nephritis were not detected. The rare association of systemic lupus erythematosus and amyloidosis is discussed in view of the characteristics of the acute phase reaction in systemic lupus erythematosus.
authors.affiliation: Department of Internal Medicine, University Hospital, Groningen, The Netherlands.
authors.forename: E J
authors.initials: EJ
authors.lastname: ter Borg
authors.forename: S
authors.initials: S
authors.lastname: Janssen
authors.forename: M H
authors.initials: MH
authors.lastname: van Rijswijk
authors.forename: J
authors.initials: J
authors.lastname: Bijzet
authors.forename: P E
authors.initials: PE
authors.lastname: de Jong
authors.forename: J D
authors.initials: JD
authors.lastname: Elema
authors.forename: C G
authors.initials: CG
authors.lastname: Kallenberg
mesh_terms: D000686:Amyloidosis / Q000150:complications* / Q000473:pathology; D001706:Biopsy; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008875:Middle Aged; D012007:Rectum / Q000378:metabolism / Q000473:pathology; D000685:Serum Amyloid A Protein
chemical_list: D000685:Serum Amyloid A Protein