[Effect of adaptation to hypoxia on the antioxidant enzyme activity in the liver in animals that have undergone stress].
It was shown in experiments on rats that emotional-painful stress resulted in a rapid increase in malonic dialdehyde (MDA) and in a decrease in the activity of superoxide dismutase (SOD) in liver. Adaptation to moderate intermittent hypoxia in altitude chamber did not affect MDA and increased hepatic SOD by 65%. Stress exposure caused no change in SOD and MDA, but abruptly reduced the fall of SOD in adapted animals. These data are in accordance with the well-known idea that adaptation to hypoxia prevents the activation of lipid peroxidation and the hepatic damage in stress.
Tverdokhlib
V P
VP
Konovalova
G G
GG
Lankin
V Z
VZ
Meerson
F Z
FZ
D000222:Adaptation, Physiological; D000818:Animals; D001273:Atmosphere Exposure Chambers; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D000860:Hypoxia / Q000201:enzymology*; D015227:Lipid Peroxidation; D008099:Liver / Q000201:enzymology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000378:metabolism*; D013997:Time Factors
D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase
Vliianie adaptatsii k gipoksii na aktivnost' antioksidantnykh fermentov v pecheni zhivotnykh, perenesshikh stress.