Formation of DNA adduct 8-hydroxy-2'-deoxyguanosine induced by man-made mineral fibres.
Two man-made mineral fibres, rockwool and glasswool, were found to mediate hydroxylation of deoxyguanosine and calf thymus DNA to form the DNA adduct 8-hydroxy-2'-deoxyguanosine. The modification of the nucleoside is probably mediated by hydroxyl radicals and may play a role in fibre-induced carcinogenesis.
Leanderson
P
P
Department of Occupational Medicine, Faculty of Health Sciences, Linköping, Sweden.
Söderkvist
P
P
Tagesson
C
C
Axelson
O
O
D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA / Q000378:metabolism*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000378:metabolism; D005898:Glass / Q000633:toxicity*; D008903:Minerals / Q000633:toxicity*; D010084:Oxidation-Reduction
D008903:Minerals; C009753:fiberglass; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D003849:Deoxyguanosine