title: [Allopurinol in the combined therapy of severe forms of epilepsy in children].
abstract: Allopurinol was tested as an antiepileptic drug (AED) in children with progressive history of the disease, frequent severe seizures and ineffective conventional AED treatment. A total of 38 children aged 4 months to 10 years were given allopurinol at daily doses of 4 to 5 mg/kg body weight. The drug had positive effects in 10 out of 28 patients having frequent seizures. Complications were not observed. Allopurinol increased serotonin content in platelets. Biochemical investigations proved the therapy with allopurinol alone or combined with other AEDs to be effective.
authors.forename: V I
authors.initials: VI
authors.lastname: Guzeva
authors.forename: V A
authors.initials: VA
authors.lastname: Gusel'
authors.forename: I B
authors.initials: IB
authors.lastname: Mikhaĭlov
mesh_terms: D000493:Allopurinol / Q000627:therapeutic use*; D000927:Anticonvulsants; D001792:Blood Platelets / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D012701:Serotonin / Q000097:blood; D013997:Time Factors
chemical_list: D000927:Anticonvulsants; D012701:Serotonin; D000493:Allopurinol
vernacular_title: Allopurinol v kompleksnoĭ terapii tiazhelykh form épilepsii u deteĭ.