title: Lack of seasonal variation in bone mass and biochemical estimates of bone turnover.
abstract: Three previous studies have indicated a seasonal variation in bone mineral content, with values during the summer being 1.7% to 7.5% higher than during the winter. We have examined the seasonal influence on both bone mass, biochemical estimates of bone turnover and vitamin D metabolites in 86 healthy women, aged 29-53 years. All participants were followed up for 2 years with examinations every 6 weeks or 3 months. Bone mineral content in the proximal and distal part of the forearm (single photon absorptiometry) did not reveal any significant seasonal variation, whereas bone mineral density of the lumbar spine (dual photon absorptiometry) indicated that the highest values occurred in winter. None of the biochemical parameters showed any statistically significant cyclical changes. Serum concentrations of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D3 showed a highly significant seasonal variation, whereas the serum 1,25-dihydroxyvitamin D concentration was virtually unchanged. We conclude that seasonal variation in bone mineral content and bone turnover should not be taken into account when interpreting data from longitudinal studies of healthy pre- and postmenopausal women on a sufficient vitamin D nutriture.
authors.affiliation: Department of Clinical Chemistry, Glostrup Hospital, University of Copenhagen, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Overgaard
authors.forename: L
authors.initials: L
authors.lastname: Nilas
authors.forename: J S
authors.initials: JS
authors.lastname: Johansen
authors.forename: C
authors.initials: C
authors.lastname: Christiansen
mesh_terms: D000328:Adult; D001842:Bone and Bones / Q000378:metabolism*; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood; D004100:Dihydroxycholecalciferols / Q000097:blood; D005260:Female; D005542:Forearm; D006801:Humans; D008137:Longitudinal Studies; D008159:Lumbar Vertebrae / Q000032:analysis; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism*; D011877:Radionuclide Imaging; D012621:Seasons
chemical_list: D004100:Dihydroxycholecalciferols; D008903:Minerals; D002117:Calcitriol; D002112:Calcifediol