Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity.
Anatoxin-a(s), an alkaloid neurotoxin from the freshwater cyanobacterium, Anabaena flos-aquae NRC-525-17, was compared to paraoxon, physostigmine and pyridostigmine for effects on brain cholinesterase after i.p. injection into Balb/c mice. The duration of clinical signs in mice injected with anatoxin-a(s) persisted longer than in mice given the carbamates and was comparable with that of paraoxon. Anatoxin-a(s) did not inhibit brain cholinesterase activity suggesting that this toxin is unable to cross the blood-brain barrier.
Cook
W O
WO
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Beasley
V R
VR
Dahlem
A M
AM
Dellinger
J A
JA
Harlin
K S
KS
Carmichael
W W
WW
D000818:Animals; D001427:Bacterial Toxins; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002802:Cholinesterases / Q000378:metabolism; D000087522:Cyanobacteria Toxins; D007928:Lethal Dose 50; D008297:Male; D008387:Marine Toxins / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D052998:Microcystins; D010261:Paraoxon / Q000494:pharmacology*; D010830:Physostigmine / Q000494:pharmacology*; D011729:Pyridostigmine Bromide / Q000494:pharmacology*; D051381:Rats; D014326:Tropanes
D001427:Bacterial Toxins; D002800:Cholinesterase Inhibitors; D000087522:Cyanobacteria Toxins; D008387:Marine Toxins; D052998:Microcystins; D014326:Tropanes; C509783:anatoxin a; D010830:Physostigmine; D002802:Cholinesterases; D011729:Pyridostigmine Bromide; D010261:Paraoxon