title: Increased urinary excretion of glycosaminoglycans in insulin-dependent diabetic patients with limited joint mobility.
abstract: Urinary excretion of glycosaminoglycans (GAG) was measured in 24-h specimens collected from 27 insulin-dependent male diabetic patients and 22 healthy males of similar ages. Excretion relative to creatinine was increased by 35% in the diabetic group as a whole (p less than 0.02). Twelve patients with limited joint mobility (cheiroarthropathy) formed a subgroup with high excretion (69% above controls), those without limited joint mobility being similar to controls. There was no correlation of retinopathy with GAG excretion.
authors.affiliation: University Department of Dermatology, Royal Infirmary, Edinburgh, Scotland.
authors.forename: G C
authors.initials: GC
authors.lastname: Priestley
authors.forename: A
authors.initials: A
authors.lastname: Collier
authors.forename: D M
authors.initials: DM
authors.lastname: Matthews
authors.forename: B F
authors.initials: BF
authors.lastname: Clarke
mesh_terms: D000328:Adult; D003404:Creatinine / Q000652:urine; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000652:urine*; D003930:Diabetic Retinopathy / Q000652:urine; D006025:Glycosaminoglycans / Q000652:urine*; D006801:Humans; D007592:Joint Diseases / Q000150:complications / Q000652:urine*; D008297:Male
chemical_list: D006025:Glycosaminoglycans; D003404:Creatinine