Long term reproducibility of urodynamic investigations in healthy fertile females.
The long term reproducibility of uroflowmetry, urethral pressure profilometry, cystometry and pressure-flow studies was evaluated in 10 healthy fertile female volunteers over a two year period. All parameters were unchanged, except for an increase in the detrusor pressure. The volume at first sensation, the maximal cystometric capacity and the maximum flow rate, had a coefficience of variation (CV) of 24%, 15% and 21% respectively. The compliance and the opening time however showed a considerably higher CV. Several parameters showed a larger intra individual standard variation (SD) than the interindividual SD, indicating that these parameters should be interpreted with great care. Repetition of the investigations showed in this small material a reduction in the standard error of the mean (SEM). Repeating the investigation reduces the number of patients needed in a clinical trial to obtain a statistically significant change. The study showed that urodynamic investigation is a reliable tool in evaluation of patients over a period of years.
Sørensen
S
S
Department of Urology K, Aarhus Municipal Hospital, Denmark.
Gregersen
H
H
Sørensen
S M
SM
D000328:Adult; D000375:Aging / Q000502:physiology; D005260:Female; D005298:Fertility; D006801:Humans; D008597:Menstrual Cycle; D012016:Reference Values; D015203:Reproducibility of Results; D013997:Time Factors; D014554:Urination; D014563:Urodynamics