[Chromosome analysis of ovocytes and human embryos collected after fertilization in vitro. A model of natural selection against aneuploidy].
Fertilization in-vitro offers the possibility of studying the karyotype of ovocytes obtained after superovulation, when they are not fertilized. Among 120 ovocytes, 30 p. cent presented a chromosomal anomaly. The same study was carried out on morphologically normal or abnormal embryos - and the percentage of chromosomal anomalies approximates here 27 p. cent. These studies offer a model of natural selection against chromosomal anomalies and confirm the limiting role of these anomalies in the success of FIV.
Plachot
M
M
INSERM U.173, UA 119 CNRS, Laboratoire de Cytogénétique Humaine et Comparée, Hôpital Necker Enfants-Malades, Paris.
De Grouchy
J
J
Junca
A M
AM
Mandelbaum
J
J
Cohen
J
J
Salat-Baroux
J
J
D000782:Aneuploidy; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007621:Karyotyping; D009865:Oocytes; D012641:Selection, Genetic; D013480:Superovulation
Analyse chromosomique des ovocytes et embryons humains obtenus après FIV. Modèle de sélection naturelle contre les aneuploïdies.