Pharmacokinetic evaluation of ofloxacin in serum and tonsils.
The bioavailability of ofloxacin in tonsil tissue, after a single oral dose of 200 mg 2 h before surgery, was evaluated in 14 patients undergoing tonsillectomy for recurrent or chronic infection. A blood specimen was obtained just before drug administration and at the time of tonsillectomy, together with a specimen of tonsil tissue. The mean values of the serum and tonsil concentrations 2 h after a single dose of 200 mg were 1.17 mg/l +/- 0.47 and 1.61 mg/l +/- 0.62 respectively with a mean tonsil/serum ratio of 1.40 +/- 0.19. These values indicate good penetration of ofloxacin into tonsil tissue. No clinical or biological side-effects were observed.
Van Landuyt
H W
HW
Department of Microbiology, A.Z. St. Jan, Brugge, Belgium.
Gordts
B
B
D'Hondt
G
G
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D006801:Humans; D015242:Ofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D014066:Palatine Tonsil / Q000378:metabolism*; D011292:Premedication; D014068:Tonsillectomy
D015242:Ofloxacin