title: Clinical and noninvasive hemodynamic results after aortic balloon valvuloplasty for aortic stenosis.
abstract: Balloon valvuloplasty has been shown to be an effective treatment for adults with aortic stenosis, typically providing a 50 to 80% increase in aortic valve area and marked improvement in exertional dyspnea, angina and syncope. However, the duration of this hemodynamic and clinical improvement is uncertain. Forty-two patients were followed for 10.2 +/- 0.5 months. Balloon valvuloplasty caused dramatic immediate reduction in the number of patients with moderate or severe dyspnea (80 to 14%), moderate or severe angina (39 to 2%) and syncope (30 to 2%). Furthermore, this improvement in symptoms continued for the duration of the follow-up period in most patients. Echocardiographic aortic valve mean gradient and area determined at 3-month intervals, however, showed a trend toward or return to prevalvuloplasty levels by 9 months' follow-up in 13 of 25 patients (52%), whereas 12 of 25 patients showed no deterioration in their hemodynamic parameters. This trend toward restenosis was accompanied by symptomatic deterioration in 5 of 13 patients (38%). This tendency toward restenosis in greater than 50% of patients by 9 months underscores the need for further technical improvements if balloon valvuloplasty is to be widely applied. Even with these limitations, however, balloon valvuloplasty seems to provide a significant improvement in actuarial survival compared with the natural history of elderly patients with severe aortic stenosis.
authors.affiliation: Department of Medicine (Cardiology), Tufts University School of Medicine, New England Medical Center Hospital, Boston, Massachusetts 02111.
authors.forename: M R
authors.initials: MR
authors.lastname: Desnoyers
authors.forename: J M
authors.initials: JM
authors.lastname: Isner
authors.forename: N G
authors.initials: NG
authors.lastname: Pandian
authors.forename: S S
authors.initials: SS
authors.lastname: Wang
authors.forename: T
authors.initials: T
authors.lastname: Hougen
authors.forename: C D
authors.initials: CD
authors.lastname: Fields
authors.forename: A R
authors.initials: AR
authors.lastname: Lucas
authors.forename: D N
authors.initials: DN
authors.lastname: Salem
mesh_terms: D000206:Actuarial Analysis; D000368:Aged; D001024:Aortic Valve Stenosis / Q000401:mortality / Q000628:therapy*; D002404:Catheterization; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics; D006801:Humans; D008297:Male; D012008:Recurrence; D013997:Time Factors