Localization of the gene for X-linked Alport's syndrome.
X-chromosomal DNA probes defining various polymorphic DNA markers were used to study genetic linkage in three families with Alport's syndrome. With the DXS17 marker, only a single cross-over was observed in 26 informative meioses, and evidence for linkage was also obtained with the DXS11 marker. These data localize the gene for the X-linked form of Alport's syndrome to the middle of the long arm of the X chromosome.
Brunner
H
H
Department of Human Genetics, University Hospital, Nijmegen, the Netherlands.
Schröder
C
C
van Bennekom
C
C
Lambermon
E
E
Tuerlings
J
J
Menzel
D
D
Olbing
H
H
Monnens
L
L
Wieringa
B
B
Ropers
H H
HH
D015342:DNA Probes; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D009394:Nephritis, Hereditary / Q000235:genetics*; D014960:X Chromosome
D015342:DNA Probes