Altered gentamicin disposition in a child with a cavernous hemangioma.
Physiologic third spacing can cause an increase in the volume of distribution of certain drugs, such as aminoglycosides, which results in a decrease in the serum concentration. The case reported here, that of a child with a large cavernous hemangioma, demonstrated this phenomenon. To obtain adequate serum and tissue concentrations, alteration of antimicrobial dosing may be needed in similar cases.
Gillespie
J B
JB
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock.
Mallory
S B
SB
Kearns
G L
GL
McCarthy
R E
RE
D000671:Amputation, Surgical; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology; D002081:Buttocks / Q000002:abnormalities / Q000601:surgery; D005260:Female; D005839:Gentamicins / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006392:Hemangioma, Cavernous / Q000150:complications / Q000151:congenital / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007866:Leg / Q000002:abnormalities / Q000601:surgery
D005839:Gentamicins