Inhibition of duck hepatitis B virus replication by purine 2',3'-dideoxynucleosides.
Primary hepatocyte cultures from duck hepatitis B virus (DHBV) infected ducklings were used to evaluate the antiviral activity of purine and pyrimidine 2',3'-dideoxynucleosides. The purine 2',3'-dideoxynucleosides were very effective inhibitors of hepadnavirus replication, whereas the pyrimidine dideoxynucleosides were not. 2',3'-Dideoxyguanosine and 2,6-diaminopurine 2',3'-dideoxyriboside (ddDAPR) were the most effective antiviral agents studied. ddDAPR given intramuscularly twice daily at 10 mg/kg rapidly cleared DHBV-DNA from the sera of persistently infected ducklings but this effect was not permanent.
Suzuki
S
S
Department of Biochemistry, University of Alberta, Edmonton, Canada.
Lee
B
B
Luo
W
W
Tovell
D
D
Robins
M J
MJ
Tyrrell
D L
DL
D000818:Animals; D002478:Cells, Cultured; D004279:DNA, Viral / Q000032:analysis; D015224:Dideoxynucleosides / Q000494:pharmacology*; D004372:Ducks; D006515:Hepatitis B virus / Q000187:drug effects*; D008099:Liver / Q000032:analysis / Q000382:microbiology; D011684:Purine Nucleosides / Q000494:pharmacology*; D011687:Purines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*
D004279:DNA, Viral; D015224:Dideoxynucleosides; D011684:Purine Nucleosides; D011687:Purines; D011743:Pyrimidines