Radiosensitizing effect of camphor on transplantable mammary adenocarcinoma in mice.
The comparative radiosensitizing effects of camphor and metronidazole on murine transplantable mammary adenocarcinoma are reported. Male C3H/Jax mice bearing transplanted mammary tumours were treated with camphor (0.5 microM/body wt) or metronidazole (0.5 microM/g body wt) 45 min before subjecting to local X-irradiation at the dose levels of 30, 80, 100 or 120 Gy. Sequential in situ measurement of the tumour volumes during the follow-up period of 45 days revealed that the maximum enhancement ratios of tumour growth delay for camphor and metronidazole were 4.8 and 2.5, respectively. This suggests that camphor can be a potential radiosensitizing agent in cancer radiotherapy.
Goel
H C
HC
Institute of Nuclear Medicine and Allied Sciences, Delhi, India.
Roa
A R
AR
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D002164:Camphor / Q000494:pharmacology*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000473:pathology*; D008795:Metronidazole / Q000494:pharmacology; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D011838:Radiation-Sensitizing Agents
D011838:Radiation-Sensitizing Agents; D008795:Metronidazole; D002164:Camphor