title: Quantitative measurement of feline colonic transit.
abstract: Colonic transit scintigraphy, a method for quantitatively evaluating the movement of the fecal stream in vivo, was employed to evaluate colonic transit in the cat. Scintigraphy was performed in duplicate in five cats and repeated four times in one cat. After instillation of an 111In marker into the cecum through a surgically implanted silicone cecostomy tube, colonic movement of the instillate was quantitated for 24 h using gamma scintigraphy. Antegrade and retrograde motion of radionuclide was observed. The cecum and ascending colon emptied rapidly, with a half-emptying time of 1.68 +/- 0.56 h (mean +/- SE). After 24 h, 25.1 +/- 5.2% of the activity remained in the transverse colon. The progression of the geometric center was initially rapid, followed later by a delayed phase. Geometric center reproducibility was found to be high when analyzed using simple linear regression (slope = 0.92; r = 0.73; P less than 0.01). Atropine (0.1 mg/kg im) was found to delay cecum and ascending colon emptying and delay progression of the geometric center. These results demonstrate both 1) the ability of colonic transit scintigraphy to detect changes in transit induced by pharmacological manipulation and 2) the fact that muscarinic blockade inhibits antegrade transit of the fecal stream. We conclude that feline colonic transit may be studied in a quantitative and reproducible manner with colonic transit scintigraphy.
authors.affiliation: Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.
authors.forename: B
authors.initials: B
authors.lastname: Krevsky
authors.forename: M B
authors.initials: MB
authors.lastname: Somers
authors.forename: A H
authors.initials: AH
authors.lastname: Maurer
authors.forename: L S
authors.initials: LS
authors.lastname: Malmud
authors.forename: L C
authors.initials: LC
authors.lastname: Knight
authors.forename: R S
authors.initials: RS
authors.lastname: Fisher
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002415:Cats; D002432:Cecum / Q000000981:diagnostic imaging / Q000502:physiology; D003106:Colon / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology*; D005772:Gastrointestinal Transit / Q000187:drug effects; D007205:Indium Radioisotopes; D011877:Radionuclide Imaging; D013997:Time Factors
chemical_list: D007205:Indium Radioisotopes; D001285:Atropine