title: Osseous xanthomatosis and a pathologic fracture in a patient with hyperlipidemia. A case report.
abstract: Osseous xanthomatosis and a pathologic fracture of the femoral neck associated with hyperlipoproteinemia occurred in a 48-year-old woman. Widely distributed skeletal lesions suggested a primary neoplasm such as malignant lymphoma or multiple myeloma; however, needle aspiration cytology of the fracture site, cutaneous manifestations, and abnormally high concentrations of lipoproteins established a diagnosis of intraosseous xanthomatosis associated with hyperlipidemia. Histologically, the excised femoral head showed a dense aggregate of lipid-laden macrophages and depletion of normal bone trabeculae. The hyperlipidemia is classified as Type IIb hyperlipoproteinemia.
authors.affiliation: National Fukuoka Central Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yokoyama
authors.forename: N
authors.initials: N
authors.lastname: Shinohara
authors.forename: K
authors.initials: K
authors.lastname: Wada
mesh_terms: D001847:Bone Diseases / Q000150:complications*; D005260:Female; D005265:Femoral Neck Fractures / Q000000981:diagnostic imaging / Q000209:etiology*; D005598:Fractures, Spontaneous / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications*; D008875:Middle Aged; D011859:Radiography; D014973:Xanthomatosis / Q000150:complications* / Q000473:pathology