[Respiratory effects of nicotine and naloxone].
The effect of an i.v. bolus injection of nicotine 50 micrograms/kg-1, was compared in 6 awake dogs with the effect of nicotine injection after naloxone, 400 micrograms/kg-1. Respiratory inhibition was produced immediately after beginning the nicotine injection, followed by hyperpnea. Naloxone produced a significant decrease of the respiratory inhibition followed by hyperpnea increase compared to the trial with only nicotine.
Jiménez-Vargas
J
J
Dpto. de Fisiologia, Facultad de Medicina, Universidad de Navarra, Pamplona.
Fernández-González
S
S
Dawid-Milner
S
S
D000818:Animals; D004285:Dogs; D007275:Injections, Intravenous; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*
D009270:Naloxone; D009538:Nicotine
Efectos respiratorios de nicotina y naloxona.