title: Mechanism of bone destruction due to middle ear cholesteatoma as revealed by laser-Raman spectrometry.
abstract: In an investigation of the mechanism of bone destruction caused by chronic otitis media complicated with cholesteatoma, both the processes of demineralization and remineralization were studied in an animal model and clinically at the molecular level, using a laser-Raman spectrometer. From this investigation, it is proposed that the mechanism of bone destruction associated with cholesteatoma is a form of demineralization.
authors.affiliation: Division of Clinical Otology, University Hospital, School of Medicine, Tokushima University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ohsaki
authors.forename: S
authors.initials: S
authors.lastname: Yamashita
authors.forename: A
authors.initials: A
authors.lastname: Fujita
authors.forename: Y
authors.initials: Y
authors.lastname: Masuda
authors.forename: S
authors.initials: S
authors.lastname: Ueda
authors.forename: T
authors.initials: T
authors.lastname: Sugiura
authors.forename: K
authors.initials: K
authors.lastname: Tamura
authors.forename: A
authors.initials: A
authors.lastname: Shibata
mesh_terms: D000328:Adult; D000818:Animals; D002781:Cholesteatoma / Q000150:complications* / Q000601:surgery; D002908:Chronic Disease; D004427:Ear Diseases / Q000150:complications* / Q000601:surgery; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism*; D010014:Osteolysis / Q000209:etiology*; D010015:Osteolysis, Essential / Q000209:etiology* / Q000378:metabolism; D010033:Otitis Media / Q000150:complications* / Q000378:metabolism; D013059:Spectrum Analysis, Raman / Q000379:methods
chemical_list: D008903:Minerals