Fragile X syndrome and acute lymphoblastic leukemia.
Fragile X [Fra(X)] syndrome is an example of a heritable fragility syndrome associated with mental retardation. It is characterized by a fragile site on the X chromosome at Xq27-28. There have recently been three reports of malignant solid tumors associated with Fra(X) syndrome. We describe the first case of a hematologic malignancy [T-cell acute lymphocytic leukemia (ALL)] in a patient with Fra(X) syndrome. The possibility of a predisposition to malignancy in Fra(X) is discussed.
Cunningham
M
M
Department of Pediatrics, University of Vermont, College of Medicine, Burlington, VT 05405.
Dickerman
J D
JD
D002675:Child, Preschool; D005600:Fragile X Syndrome / Q000150:complications*; D006801:Humans; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D012729:Sex Chromosome Aberrations / Q000150:complications*