title: Oligosaccharides from faeces of a blood-group B, breast-fed infant.
abstract: Eight oligosaccharides have been isolated from faeces of a blood group B, secretor, breast-fed infant and characterized by sugar and methylation analysis, f.a.b. mass spectrometry and 1H-n.m.r. spectroscopy. One of these oligosaccharides has not previously been reported and is a tri-L-fucosyl derivative of lacto-N-hexaose. The other compounds were identical to oligosaccharides found in human milk. Several of the reported compounds require the secretor dependent 2'-fucosyltransferase for their biosynthesis. Since the mother of this child was an O(H) non-secretor, an intestinal biosynthesis of at least some of these compounds is strongly indicated. No blood group B active oligosaccharides were detected which is in sharp contrast to the oligosaccharide excretion in faeces from a blood group A infant [Sabharwal et al., Mol. Immunol., 21 (1984) 1105-1112] in which all the major oligosaccharides isolated were blood group A active.
authors.affiliation: Department of Clinical Chemistry, University Hospital, Lund, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Sabharwal
authors.forename: B
authors.initials: B
authors.lastname: Nilsson
authors.forename: M A
authors.initials: MA
authors.lastname: Chester
authors.forename: F
authors.initials: F
authors.lastname: Lindh
authors.forename: G
authors.initials: G
authors.lastname: Grönberg
authors.forename: S
authors.initials: S
authors.lastname: Sjöblad
authors.forename: A
authors.initials: A
authors.lastname: Lundblad
mesh_terms: D000017:ABO Blood-Group System; D001942:Breast Feeding; D002240:Carbohydrate Sequence; D005243:Feces / Q000032:analysis*; D006801:Humans; D007223:Infant; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000032:analysis*; D012016:Reference Values
chemical_list: D000017:ABO Blood-Group System; D009844:Oligosaccharides