title: [The stability of norepinephrine hydrogen tartrate, epinephrine hydrogen tartrate and isoprenaline sulfate. 29. The stability of drugs and preparations].
abstract: Stability testing of derivatives of brenzcatechine [norepinephrine hydrogentartrate (1), epinephrine hydrogentartrate (2), isoprenaline sulfate (3)] was carried out by stress investigation storing them at different temperatures. Substances of different charges which had been stored under normal conditions were analyzed. After a period of induction all three substances had been decomposed with a higher velocity. The order of kinetic process could not be determined. The storage life time was calculated by the aid of nonlinear regression. Time limit for storage of 5 years for 1 and 2 were confirmed. We suggest to extend it for 3 to 10 years.
authors.affiliation: Sektion Pharmazie der Ernst-Moritz-Arndt-Universität Greifswald.
authors.forename: C
authors.initials: C
authors.lastname: Müller
authors.forename: G
authors.initials: G
authors.lastname: Burghardt
authors.forename: H
authors.initials: H
authors.lastname: Wollmann
mesh_terms: D004355:Drug Stability; D004837:Epinephrine / Q000032:analysis*; D007545:Isoproterenol / Q000032:analysis*; D007700:Kinetics; D009638:Norepinephrine / Q000032:analysis*
chemical_list: D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine
vernacular_title: Untersuchungen zur Stabilität von Norepinephrinehydrogentartrat, Epinephrinhydrogentartrat und Isoprenalinsulfat. 29. Mitteilung: Sabilität von Arzneistoffen und Zubereitungen.