Absence of detectable chromosomal and molecular abnormalities in monozygotic twins discordant for the Wiedemann-Beckwith syndrome.
Monozygotic twins discordant for the Wiedemann-Beckwith syndrome (WBS) were studied by cytogenetic and molecular methods to determine if a genetic lesion could be detected in the affected child. Probes known to be localized on the short arm of chromosome 11 and a low copy-repetitive probe were used. No genetic lesions could be ascertained in normal or affected tissue obtained from the WBS twin.
Litz
C E
CE
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis.
Taylor
K A
KA
Qiu
J S
JS
Pescovitz
O H
OH
de Martinville
B
B
D001506:Beckwith-Wiedemann Syndrome / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D015342:DNA Probes; D004200:Diseases in Twins; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007223:Infant; D010641:Phenotype; D014430:Twins, Monozygotic
D015342:DNA Probes; D005819:Genetic Markers