Plasma and tissue concentrations of coenzyme Q10 in the rat after its oral administration.
Coenzyme Q10 (CoQ10) kinetics was investigated in rat tissues after oral treatment. CoQ10 passes quickly from plasma into the tissue examined, reaching levels higher than physiological ones; the liver shows the maximal CoQ10 concentrations. Our results indicate that oral treatment makes it possible to obtain good tissue levels of CoQ10 that might be of clinical value against endogenous CoQ10 insufficiencies due either to pathological alterations and/or to drug administration.
Scalori
V
V
Institute of Pharmacology, School of Medicine, University of Pisa, Italy.
Alessandrì
M G
MG
Mian
M
M
Giovannini
L
L
Bertelli
A A
AA
D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003067:Coenzymes; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10