First demonstration of recombination between the gene for Norrie disease and probe L1.28.
Norrie disease is an X-linked trait thought to be tightly linked to the anonymous probe L1.28. Here we report the first recombinational event among 24 informative meioses. This indicates there is a 4% (95% C.L. 0.1%-21%) error rate introduced by meiotic crossovers in carrier or prenatal diagnosis based on linkage between Norrie disease and L1.28.
Katayama
S
S
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco.
Wohlferd
M
M
Golbus
M S
MS
D001766:Blindness / Q000235:genetics*; D015342:DNA Probes; D005808:Genes, Recessive; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic; D014960:X Chromosome
D015342:DNA Probes