[The role of the perifornix area of the hypothalamus in forming alcoholic motivation in rats].
In rats with alcohol motivation on the model of water deprivation with substitution of water for 20% ethanol solution, motivatiogenic "drinking centres" of the hypothalamus initiate in response to electro- and chemostimulation (acetylcholine) behavioural reactions of search and taking of alcohol and not of water. Electrolytic ablation of "thirst centres" of the perifornical hypothalamus area in rats with a formed attraction to alcohol is accompanied by a decrease of its taking during 3-5 days of observation. Microinjections of dipsogenic peptide angiotensin II, unlike acetylcholine administration, do not initiate taking of water or alcohol, but elicit only appearance of orienting-investigating, alimentary, sexual and other behavioural reactions. It is suggested that formation of alcohol motivation in these conditions is connected with a change of neurophysiological and neurochemical properties of the hypothalamus "thirst centres" initiating an active search and taking of alcohol and not of the water in rats with experimental alcoholism.
Kelesheva
L F
LF
Kotov
A V
AV
D000109:Acetylcholine / Q000494:pharmacology; D000428:Alcohol Drinking / Q000187:drug effects / Q000502:physiology*; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D004558:Electric Stimulation; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009042:Motivation / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D014868:Water Deprivation / Q000187:drug effects / Q000502:physiology
D000804:Angiotensin II; D000109:Acetylcholine
Rol' perifornikal'noĭ oblasti gipotalamusa v formirovanii alkogol'noĭ motivatsii u krys.