[The effect of psychotropic substances on the deamination of monoamines in the rat brain].
A comparative study of antimonoamine oxidase activity of psychotropic agents of different classes was made. Phenothiazine, butyrophenone and atypical neuroleptics were found to suppress deamination of 2-phenylethylamine in the brain. Tranquilizers of benzodiazepine structure appeared to be inactive with respect to monoamine oxidase (MAO) of the brain. Anticonvulsants (except difenin) weakly inhibit serotonin deamination and, on the contrary, difenin stimulates serotonin- and 2-phenylethylamine deamination. Antidepressants--MAO inhibitors--more actively reduce the rate of serotonin deamination, and tricyclic antidepressant desimipramine is similar to aminazine by its effect on MAO. Phenamine is a potent MAO inhibitor. The effect of cocaine is significantly less pronounced.
Gol'dina
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D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003641:Deamination; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D010084:Oxidation-Reduction / Q000187:drug effects; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats
D015306:Biogenic Monoamines; D011619:Psychotropic Drugs
Vliianie psikhotropnykh veshchestv na dezaminirovanie monoaminov v mozge krysy.