Haemoglobin adducts of aromatic amines in people exposed to cigarette smoke.
In a population-based study in Turin, Italy, smokers of blond tobacco showed 4-aminobiphenyl (4-ABP) adduct levels some three times higher than nonsmoking subjects, and smokers of black tobacco showed levels about five times greater than nonsmokers. A dose-response relationship between the number of cigarettes smoked per day and 4-ABP adduct level was observed, but did not account for the higher adduct levels observed in smokers of black tobacco. Smoking-related increases in haemoglobin adducts were also observed for o-toluidine, p-toluidine, 2,4-dimethylaniline and 2-ethylaniline. Smoking subjects showed 3-aminobiphenyl adduct levels about 12 times greater than those of nonsmokers, who rarely showed a detectable level. This may indicate that there are fewer sources of 3-aminobiphenyl exposure not related to tobacco smoke. Smokers of black tobacco showed higher adduct levels than smokers of blond tobacco for 4-ABP, p-toluidine and 2,4-dimethylaniline.
Bryant
M S
MS
Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge.
Vineis
P
P
Skipper
P L
PL
Tannenbaum
S R
SR
D015081:2-Naphthylamine / Q000097:blood; D000328:Adult; D000611:Aminobiphenyl Compounds / Q000097:blood*; D004784:Environmental Monitoring; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008297:Male; D012907:Smoking / Q000097:blood*; D001749:Urinary Bladder Neoplasms / Q000209:etiology
D000611:Aminobiphenyl Compounds; D006454:Hemoglobins; C006757:4-biphenylamine; D015081:2-Naphthylamine; C049671:3-aminobiphenyl