Is free halogen necessary for disinfection?
The principle of Le Chatelier was used in demonstrating that 3-chloro-4,4-dimethyl-2-oxazolidinone (compound 1) itself kills Staphylococcus aureus rather than the very small amount of free chlorine in hydrolysis equilibrium with compound 1. On the other hand, when the N-bromo analog of compound 1 (compound 1B) was used as the disinfectant, the mixture of combined compound 1B and free bromine formed in the hydrolysis equilibrium provided disinfection. When the hydrolysis equilibrium for 1B was suppressed to the level at which a negligible amount of free bromine remained in solution, combined compound 1B was much more efficacious than combined compound 1 at killing S. aureus.
Williams
D E
DE
Department of Chemistry, College of Sciences and Mathematics, Auburn University, Alabama 36849.
Elder
E D
ED
Worley
S D
SD
D001966:Bromine / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D002713:Chlorine / Q000494:pharmacology*; D004202:Disinfectants / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D023303:Oxazolidinones; D013211:Staphylococcus aureus / Q000187:drug effects*
D004202:Disinfectants; D010080:Oxazoles; D023303:Oxazolidinones; D002713:Chlorine; C036350:3-chloro-4,4-dimethyl-2-oxazolidinone; D001966:Bromine