Microinjections of GABA agonists into the amygdala complex attenuates kindled seizure expression in the rat.
The effects of intraamygdala injections of either gamma-vinyl GABA or muscimol on the behavioral and electrographic expression of stable, fully generalized, kindled seizures were assessed. Results suggest that intraamygdala administration of GABA agonists preferentially attenuates the behavioral, but not the focal, electrographic expression of kindled seizures elicited from either the insular or entorhinal cortex. These results, in conjunction with those of others, suggest that the amygdala becomes an integral and necessary structure for the expression of seizures kindled from a variety of forebrain areas.
Applegate
C D
CD
Laboratory of Developmental Neurophysiology, Children's Hospital, Boston, Massachusetts.
Burchfiel
J L
JL
D000614:Aminocaproates / Q000494:pharmacology; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002540:Cerebral Cortex / Q000502:physiology; D007696:Kindling, Neurologic; D008032:Limbic System / Q000502:physiology; D008297:Male; D008845:Microinjections; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000209:etiology* / Q000503:physiopathology; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000614:Aminocaproates; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D020888:Vigabatrin