title: Localization of the gene for X-linked Alport's syndrome.
abstract: X-chromosomal DNA probes defining various polymorphic DNA markers were used to study genetic linkage in three families with Alport's syndrome. With the DXS17 marker, only a single cross-over was observed in 26 informative meioses, and evidence for linkage was also obtained with the DXS11 marker. These data localize the gene for the X-linked form of Alport's syndrome to the middle of the long arm of the X chromosome.
authors.affiliation: Department of Human Genetics, University Hospital, Nijmegen, the Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Brunner
authors.forename: C
authors.initials: C
authors.lastname: Schröder
authors.forename: C
authors.initials: C
authors.lastname: van Bennekom
authors.forename: E
authors.initials: E
authors.lastname: Lambermon
authors.forename: J
authors.initials: J
authors.lastname: Tuerlings
authors.forename: D
authors.initials: D
authors.lastname: Menzel
authors.forename: H
authors.initials: H
authors.lastname: Olbing
authors.forename: L
authors.initials: L
authors.lastname: Monnens
authors.forename: B
authors.initials: B
authors.lastname: Wieringa
authors.forename: H H
authors.initials: HH
authors.lastname: Ropers
mesh_terms: D015342:DNA Probes; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D009394:Nephritis, Hereditary / Q000235:genetics*; D014960:X Chromosome
chemical_list: D015342:DNA Probes