title: Effect of ICS 205-930 (a specific 5-HT3 receptor antagonist) on gastric emptying of a solid meal in normal subjects.
abstract: The effects on gastric emptying of a solid meal of the specific 5-HT3-receptor antagonist ICS 205-930, 10 mg and 20 mg intravenously were assessed with a scintigraphic technique in 12 normals. The 50% emptying time was less, the lag phase was shorter and the post lag emptying rate was faster after 20 mg ICS 205-930 (p less than 0.02). After 10 mg ICS 205-930 the lag phase was significantly shorter compared with placebo (p less than 0.04). These results suggest that 5-HT3 receptors may be involved in the regulation of gastric emptying in man.
authors.affiliation: Department of Surgery, University Hospital Utrecht, The Netherlands.
authors.forename: L M
authors.initials: LM
authors.lastname: Akkermans
authors.forename: A
authors.initials: A
authors.lastname: Vos
authors.forename: A
authors.initials: A
authors.lastname: Hoekstra
authors.forename: J M
authors.initials: JM
authors.lastname: Roelofs
authors.forename: M
authors.initials: M
authors.lastname: Horowitz
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D012702:Serotonin Antagonists / Q000494:pharmacology*; D000077526:Tropisetron
chemical_list: D007211:Indoles; D012702:Serotonin Antagonists; D000077526:Tropisetron