title: The influence of oral contraceptives on hormonal and metabolic homeostasis in young adolescents.
abstract: In order to evaluate the effects of oral contraceptives on metabolic and endocrine function in teenagers, Norinyl 1/50 was begun in 46 12-17-year-old girls after a 16-hour-fasting blood sample was obtained for glucose, insulin, glucagon, growth hormone, luteinizing hormone, follicle-stimulating hormone, thyroid-stimulating hormone, prolactin, gluconeogenic substrates, total lipids, and cholesterol. Sampling was repeated at 6 and 12 months of therapy. Of the 46 patients enrolled in the study, 23 returned for follow-up after 6 months, and 13 completed the study. Blood sampling after 6 and 12 months of therapy demonstrated no significant changes (p greater than 0.05). Our results suggest that there were no changes in the metabolic or endocrine functions studied at 6 and 12 months on a medium-dose contraceptive agent.
authors.affiliation: Section of Adolescent Medicine, Children's Mercy Hospital, Kansas City, MO 64108.
authors.forename: K W
authors.initials: KW
authors.lastname: Smith
authors.forename: C P
authors.initials: CP
authors.lastname: Howard
authors.forename: B J
authors.initials: BJ
authors.lastname: Allphin
authors.forename: J A
authors.initials: JA
authors.lastname: Grunt
mesh_terms: D000293:Adolescent; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D006706:Homeostasis / Q000187:drug effects*; D006728:Hormones / Q000097:blood*; D006801:Humans; D008656:Mestranol / Q000494:pharmacology; D008660:Metabolism / Q000187:drug effects*; D009640:Norethindrone / Q000494:pharmacology
chemical_list: D003277:Contraceptives, Oral, Combined; D003280:Contraceptives, Oral, Synthetic; D004338:Drug Combinations; D006728:Hormones; C014715:Norinyl; D008656:Mestranol; D009640:Norethindrone