title: Robust regression in biological assay: application to the evaluation of alternative experimental techniques.
abstract: Robust Huber type regression and testing of linear hypotheses are adapted to statistical analysis of parallel line and slope ratio assays. They are applied in the evaluation of results of several experiments carried out in order to compare and validate alternatives to animal experimentation based on embryo and cell cultures. Computational procedures necessary for the application of robust methods of analysis used the conversational statistical package ROBSYS. Special commands for the analysis of parallel line and slope ratio assays have been added to ROBSYS.
authors.affiliation: Institute of Social and Preventive Medicine, University of Lausanne, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Marazzi
authors.forename: C
authors.initials: C
authors.lastname: Ruffieux
authors.forename: A
authors.initials: A
authors.lastname: Randriamiharisoa
mesh_terms: D000826:Animal Testing Alternatives; D000818:Animals; D001681:Biological Assay; D001921:Brain; D002110:Caffeine / Q000633:toxicity; D002478:Cells, Cultured; D002642:Chick Embryo; D046508:Culture Techniques; D004622:Embryo, Mammalian; D010672:Phenytoin / Q000633:toxicity; D051381:Rats; D012044:Regression Analysis; D012984:Software; D013223:Statistics as Topic
chemical_list: D002110:Caffeine; D010672:Phenytoin