title: [Identification of aberrant chromosomes based on the morphometry of the synaptonemal complexes in a sterile male mouse].
abstract: The synaptonemal complexes (SCs) of surface-spread spermatocytes of male mouse from the F1 progeny of a male exposed to a mutagen have been examined by electron microscopy. Nonreciprocal translocation was recognised in analysing configuration of SC. Electron microscope analysis revealed translocation in 100% pachytene spermatocytes and light microscope analysis of air-dried metaphase spermatocytes demonstrated this in 58% cells. Different types of association of X-chromosome with aberrant chromosomes were discovered in pachytene spermatocytes. Computer analysis of relative length of SCs permits to detect a nonreciprocal translocation from chromosome 4 to chromosome 16. The length of the translocated fragment was determined to be from 66 to 75% of the length of chromosome 4. It has been impossible to discover a telomere fragment of chromosome 16, because the break point of chromosome 16 is too close to the distal end.
authors.forename: E I
authors.initials: EI
authors.lastname: Kalikinskaia
authors.forename: V V
authors.initials: VV
authors.lastname: Chepyzhov
authors.forename: Iu F
authors.initials: IuF
authors.lastname: Bogdanov
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000648:ultrastructure; D007248:Infertility, Male / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008540:Meiosis; D008677:Metaphase; D051379:Mice; D008854:Microscopy, Electron; D012729:Sex Chromosome Aberrations / Q000150:complications / Q000235:genetics / Q000473:pathology; D013090:Spermatocytes / Q000648:ultrastructure; D013573:Synaptonemal Complex; D014178:Translocation, Genetic; D014960:X Chromosome / Q000648:ultrastructure
vernacular_title: Identifikatsiia aberrantnykh khromosom na osnove morfometrii sinaptonemnykh kompleksov u steril'nogo samtsa myshi.