A preliminary vaccine potency trial of a Newcastle disease virus inactivated with binary ethylenimine.
Inactivation of Newcastle Disease Virus (NDV) by binary ethylenimine (BEI) is reported. The activity of an oil vaccine prepared with BEI-inactivated NDV was compared to a vaccine prepared with formalin-inactivated NDV. The BEI inactivated vaccine had almost twice the efficacy.
Buonavoglia
C
C
Istituto Superiore di Sanità, Laboratorio di Medicina Veterinaria, Roma, Italy.
Fioretti
A
A
Tollis
M
M
Menna
F
F
Papparella
V
V
D000818:Animals; D001388:Aziridines / Q000494:pharmacology; D002645:Chickens; D005557:Formaldehyde; D006801:Humans; D009521:Newcastle Disease / Q000517:prevention & control*; D009522:Newcastle disease virus / Q000276:immunology*; D015164:Vaccines, Inactivated; D014765:Viral Vaccines
D001388:Aziridines; D015164:Vaccines, Inactivated; D014765:Viral Vaccines; D005557:Formaldehyde