The in vivo effects of autonomic drugs and electroejaculation on prostate gland contractility in the rat.
The effects of various autonomic drugs and electroejaculation on the contractile activity of the rat prostate were registered in vivo by means of a video recording system. The changes in the glandular tone were measured by observing the modification of distance between two superficial paralel blood vessels used as references. Norepinephrine, epinephrine, acetylcholine and electrical stimulations produced an increase in the ronus. Since terbutaline had no effect, and phentolamine prevented the effects of both norepinephrine and epinephrine but propranolol did not, it resulted that contractility of the prostate is enhanced when the alpha-adrenoceptors are stimulated, and it is not affected by the stimulation of beta-adrenoceptors. The effects of acetylcholine were blocked by atropine, indicating that they are of the muscarinic type. The excitatory response of the prostate to electroejaculation appeared to be resistant to blockade by phentolamine and atropine.
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Centro de Investigaciones en Reproducción, Facultad de Medicina, Buenos Aires, Argentina.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001337:Autonomic Agents / Q000494:pharmacology*; D004542:Ejaculation; D004558:Electric Stimulation; D004837:Epinephrine / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011467:Prostate / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013726:Terbutaline / Q000494:pharmacology; D014743:Videotape Recording
D001337:Autonomic Agents; D011433:Propranolol; D013726:Terbutaline; D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine