title: [What sequence must have an 8-nucleotide anticodon loop so that tRNA would not shift the reading frame?].
abstract: A model describing the interaction between the anticodon loop consisting of eight nucleotides and messenger RNA is proposed. A suggestion is made that the ability of eight nucleotide loop to recognize a four base codon and as a result to shift a reading frame, depends on the location of the sharp turn of polynucleotide chain within the anticodon loop. The turn will appear to be only immediately after U. This U fixes the position of the turn by the formation of the specific hydrogen bond and van-der-Vaals contacts, that are found in the common seven nucleotide anticodon loop. The model predicts whether a particular tRNA will be able to shift a reading frame or not. This prediction is in agreement with available experimental data.
authors.forename: S V
authors.initials: SV
authors.lastname: Shteĭnberg
mesh_terms: D000926:Anticodon / Q000235:genetics*; D001483:Base Sequence; D005815:Genetic Code; D008957:Models, Genetic; D012343:RNA, Transfer / Q000235:genetics*; D013698:Templates, Genetic
chemical_list: D000926:Anticodon; D012343:RNA, Transfer
vernacular_title: Kakuiu posledovatel'nost' dolzhna imet' vos'minukleotidnaia antikodonovaia petlia, chtoby tRNK ne sdvigala ramku schityvaniia?