Material thrombelastography: an assessment of phosphorylcholine compounds as models for biomaterials.
The use of phosphorylcholine (PC) containing compounds as possible biomaterials has been evaluated by material thrombelastography (MTEG). The detailed analysis of the MTEG technique is discussed. A remarkable reduction of thrombogenicity by compounds containing the PC group is demonstrated. The results observed with a polymerised PC-lipid indicate potential use of such substances as biomaterials with minimal thrombogenicity.
Bird
R R
RR
Academic Department of Surgery, Royal Free Hospital School of Medicine, University of London, United Kingdom.
Hall
B
B
Chapman
D
D
Hobbs
K E
KE
D015060:1,2-Dipalmitoylphosphatidylcholine / Q000494:pharmacology; D001672:Biocompatible Materials; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing / Q000379:methods*; D010713:Phosphatidylcholines / Q000494:pharmacology; D013916:Thrombelastography; D013927:Thrombosis / Q000517:prevention & control
D001672:Biocompatible Materials; D010713:Phosphatidylcholines; C044819:1,2-diarachidonoyl-glycero-3-phosphocholine; D015060:1,2-Dipalmitoylphosphatidylcholine