title: Linearity of metoclopramide kinetics at doses of 5-20 mg.
abstract: The disposition of metoclopramide was studied on a four-way crossover basis in six healthy non-smoking volunteers. The linearity of kinetic parameters and absolute bioavailability of metoclopramide were examined. In contrast to previous reports, metoclopramide obeyed linear kinetics over oral doses ranging from 5 to 20 mg. The absolute bioavailability of metoclopramide was 0.76 +/- 0.38 (mean +/- s.d.) from the oral dosage forms examined in this study.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
authors.forename: M R
authors.initials: MR
authors.lastname: Wright
authors.forename: J E
authors.initials: JE
authors.lastname: Axelson
authors.forename: D W
authors.initials: DW
authors.lastname: Rurak
authors.forename: B
authors.initials: B
authors.lastname: McErlane
authors.forename: G H
authors.initials: GH
authors.lastname: McMorland
authors.forename: R C
authors.initials: RC
authors.lastname: Ongley
authors.forename: Y K
authors.initials: YK
authors.lastname: Tam
authors.forename: J D
authors.initials: JD
authors.lastname: Price
mesh_terms: D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008787:Metoclopramide / Q000493:pharmacokinetics*
chemical_list: D008787:Metoclopramide