title: X-Y crossing over in the chimpanzee.
abstract: Single-copy DNA sequences defining several pseudoautosomal loci on the human sex chromosomes are shown to be highly conserved in the genome of the chimpanzee. Segregation analysis of polymorphic pseudoautosomal probes in a chimpanzee pedigree revealed that the transmission of the paternal alleles was not strictly sex-linked. In situ hybridization localized the pseudoautosomal probe 29C1 specifically to Xp22-Xpter and to Yq12.2-Yqter on the chimpanzee sex chromosomes. Thus, our results demonstrate the existence of homologous segments on the chimpanzee X and Y chromosomes, which regularly undergo recombinatory exchange in male meiosis. The chimpanzee is now the third mammalian species, besides man and mouse, in which there is genetic evidence for a pseudoautosomal segment on the sex chromosomes.
authors.affiliation: Institut für Humangenetik und Anthropologie der Universität, Freiburg i. Br., Federal Republic of Germany.
authors.forename: B
authors.initials: B
authors.lastname: Weber
authors.forename: J
authors.initials: J
authors.lastname: Weissenbach
authors.forename: W
authors.initials: W
authors.lastname: Schempp
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002871:Chromosome Banding; D003434:Crossing Over, Genetic; D005260:Female; D007621:Karyotyping; D008297:Male; D002679:Pan troglodytes / Q000235:genetics*; D010375:Pedigree; D014960:X Chromosome; D014998:Y Chromosome