Sulfhydryl oxidation and Ca2+ release from sarcoplasmic reticulum.
Our interest in the role of sulfhydryl groups (SH) in regulating or altering transport across biological membranes has focused on the significance of a critical SH group associated with the Ca2+-release protein from skeletal muscle sarcoplasmic reticulum (SR). We have shown that binding of heavy metals to this group or oxidation of this sulfhydryl to a disulfide induces rapid Ca2+ release from SR vesicles and induces contraction in skinned muscle fibers. Several models are described in which oxidation and reduction might control the state of the Ca2+-release channel from SR.
Abramson
J J
JJ
Department of Physics, Portland State University, Oregon 97207.
Salama
G
G
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D008670:Metals / Q000494:pharmacology; D010084:Oxidation-Reduction; D013438:Sulfhydryl Compounds / Q000378:metabolism*
D008670:Metals; D013438:Sulfhydryl Compounds; D002118:Calcium