Premature rupture of fetal membranes changes in collagen type.
Collagen from the chorioamnion units from premature and term pregnancies was solubilized by limited pepsin digestion and subjected to SDS-PAG electrophoresis. Collagen types were quantitated by densitometry. It was found that collagen type III decreases and collagen type V tends to increase as gestational age advances. Investigating the relative abundance of collagen types at various membrane sites from term pregnancies revealed that type V decreases in the amnion as the rupture site is approached. It is concluded that since type V collagen is more resistant to collagenases, its decrease may predispose that particular site to rupture.
al-Zaid
N S
NS
Department of Physiology, Faculty of Medicine, Kuwait University.
Gumaa
K A
KA
Bou-Resli
M N
MN
Ibrahim
M E
ME
D000650:Amnion / Q000378:metabolism; D002823:Chorion / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D003720:Densitometry; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000378:metabolism*; D006801:Humans; D011247:Pregnancy
D003094:Collagen