Failure of penicillin prophylaxis in laboratory acquired leptospirosis.
A laboratory technician developed leptospirosis following accidental inoculation, despite prompt administration of parenteral penicillin by an accepted regimen of post-exposure prophylaxis. Another technician was similarly exposed and was given doxycycline; no illness or serological conversion followed. The implications of these cases are discussed and recommendations made for post-exposure chemoprophylaxis with doxycycline.
Gilks
C F
CF
St. George's Hospital, London, UK.
Lambert
H P
HP
Broughton
E S
ES
Baker
C C
CC
D000062:Accidents, Occupational; D000328:Adult; D004318:Doxycycline / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007757:Laboratory Infection / Q000517:prevention & control*; D007921:Leptospira interrogans; D007922:Leptospirosis / Q000517:prevention & control*; D010400:Penicillin G / Q000627:therapeutic use*; D010403:Penicillin Resistance
D004318:Doxycycline; D010400:Penicillin G