Antibacterial effect of etoposide in vitro.
Etoposide, an antitumor drug, had an effect in vitro against all strains of gram-positive bacteria studied but not against three gram-negative bacteria. The MICs ranged between 6.2 and 50 micrograms/ml. In short-term-growth experiments, etoposide had a bactericidal efficacy that was 10 to 50 times lower than that of cloxacillin.
Calame
W
W
Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
van der Waals
R
R
Douwes-Idema
N
N
Mattie
H
H
van Furth
R
R
D005047:Etoposide / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
D005047:Etoposide