[Comparison of enoxacin, ofloxacin, and norfloxacin concentration in human benign prostatic tissue].
The penetration of pyridone-carboxylic acid drugs into benign prostatic tissue was examined. Twenty-nine patients were studied; 11 for ofloxacin (OFLX) 10 for enoxacin (ENX); and 8 for norfloxacin (NFLX). These drugs were administered orally at a dose of 200 mg three times one day before and twice on the day of operation. Blood sample was taken 30 min before operation and prostatic tissue sample was taken during operation. The mean prostatic concentration of ENX, OFLX and NFLX was 5.81 +/- 2.95 micrograms/g (range 2.99-7.92), 5.51 +/- 1.79 (3.62-7.19), and 4.42 +/- 1.94 (2.45-7.76), respectively. The mean serum concentration of ENX, OFLX and NFLX was 4.87 +/- 1.39 micrograms/ml (3.13-7.44), 5.36 +/- 1.28 (3.12-8.24), and 2.89 +/- 2.34 (0.87-8.33), respectively. The mean ratio of prostatic concentration/serum concentration of ENX, OFLX and NFLX was 1.21 +/- 0.63 (0.82-3.00), 1.06 +/- 0.31, (0.55-1.54) and 2.06 +/- 1.36 (0.93-4.26), respectively. Our findings suggested that the drugs ENX, OFLX and NFLX are useful for prostatic diseases, especially prostatitis.
Yasumoto
R
R
Department of Urology, Osaka Municipal Kita Citizen's Hospital.
Asakawa
M
M
D000284:Administration, Oral; D015365:Enoxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D009643:Norfloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D015242:Ofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011467:Prostate / Q000378:metabolism*; D014018:Tissue Distribution
D015365:Enoxacin; D015242:Ofloxacin; D009643:Norfloxacin