Effect of glycerol treatment on pulmonary lipid metabolism in mice.
In this study, we demonstrated that glycerol treatment caused the alterations of pulmonary lipid compositions in ddY mice. The increases of total phospholipid (TPL), diacylglyceride (DG), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) + phosphatidylglycerol (PG) contents in the lung were observed by oral administration of 5% glycerol in drinking water for 2 weeks. However, other pulmonary lipid components measured in this study were almost unchanged by this treatment. These results suggest that glycerol treatment might induce changes of pulmonary lipid metabolism in mice.
Yano
T
T
Department of Pathology, Yokohama City University School of Medicine, Japan.
Nagahara
N
N
Kitamura
H
H
Kanisawa
M
M
D000818:Animals; D004075:Diglycerides / Q000378:metabolism; D005990:Glycerol / Q000494:pharmacology*; D050356:Lipid Metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010715:Phosphatidylglycerols / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism
D004075:Diglycerides; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010715:Phosphatidylglycerols; D010743:Phospholipids; D005990:Glycerol