HLA antigens and clinical manifestations in Crohn's disease.
A clinical, radiological and immunogenetical study was carried out on 51 Crohn's patients. Rheumatological disorders were found in 16 of them, with higher frequency in those with colon involvement only. A statistically significant increase in the frequencies of HLA-A9 and HLA-Cw3 was noted: Cw3 showed a particularly high frequency in males, and A9 in younger patients. The frequency of HLA-B27 was significantly increased in the patients with colon involvement. In the group of 16 patients with rheumatic diseases HLA antigen frequencies were not significantly different from the control population.
Modena
V
V
Divisione di Reumatologia, Ospedale S. Giovanni, Torino, Italy.
Amoroso
A
A
Frattasio
C
C
Pera
A
A
Costantini
P
P
Maiocco
I
I
Ponti
V
V
Di Vittorio
C C
CC
Verme
G
G
Curtoni
E S
ES
D000328:Adult; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002415:Cats; D003092:Colitis / Q000276:immunology; D003424:Crohn Disease / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007079:Ileitis / Q000276:immunology; D008297:Male; D013167:Spondylitis, Ankylosing / Q000276:immunology
D006680:HLA Antigens