title: [Plasma concentrations of clomipramine and its desmethyl metabolite in man. Methodologic limits].
abstract: The purpose of the present work was to study the correlations between clinical response and plasma concentrations of clomipramine or desmethylclomipramine, using two different methods of dosage: radio-immunoassay and high pressure liquid chromatography, compared with mass spectrometry method. The results vary according to the method used, suggesting that methodological problems might explain, at least partly, the discrepancies observed in the literature.
authors.affiliation: Service de Psychiatrie A, CHU Saint-Jacques, Clermont-Ferrand.
authors.forename: I
authors.initials: I
authors.lastname: Piollet
authors.forename: C
authors.initials: C
authors.lastname: Goyot
authors.forename: M
authors.initials: M
authors.lastname: Paire
authors.forename: A
authors.initials: A
authors.lastname: Touzery
authors.forename: A
authors.initials: A
authors.lastname: Eschalier
authors.forename: L
authors.initials: L
authors.lastname: Dehennin
authors.forename: J
authors.initials: J
authors.lastname: Grenier
authors.forename: J
authors.initials: J
authors.lastname: Lavarenne
authors.forename: E
authors.initials: E
authors.lastname: Zarifian
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002997:Clomipramine / Q000031:analogs & derivatives* / Q000097:blood* / Q000378:metabolism / Q000627:therapeutic use; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D011863:Radioimmunoassay
chemical_list: C012273:desmethylclomipramine; D002997:Clomipramine
vernacular_title: Etude des concentrations plasmatiques de la clomipramine et de son dérivé déméthylé chez l'homme. Limites méthodologiques.