title: Experimental tissue molding for soft-tissue reconstruction: a preliminary report.
abstract: Molding of pig omentum to create external structures, such as the ear or penis, was performed using silicone rubber molds. The omentum was mobilized on its gastroepiploic pedicle and brought out through a fascial defect. The molds containing the omentum were placed beneath the skin and panniculus carnosus for 4 weeks. Split-thickness skin grafts were placed on both surfaces of the mold, and a series of synthetic materials was placed within the omentum to provide structural support. When an appropriate amount of tissue had been placed within the device, omentum took on the contour of the mold. Excessive pressure associated with swelling resulted in necrosis, while an inadequate amount of tissue gave poor contour. Omentum molded without any support material rapidly lost its contour once removed from the mold. Omentum molded in combination with a synthetic material maintained its shape up to 1 month after mold removal in a limited number of animals. This model was designed to create structures with the fine detail of a prosthesis using autologous tissue. This "prosthesis" made from living tissue could then be transferred secondarily to its recipient area by microvascular technique.
authors.affiliation: Meharry Medical College, HCA Center for Research and Education, Nashville, Tenn. 37203.
authors.forename: J
authors.initials: J
authors.lastname: Fisher
authors.forename: W Y
authors.initials: WY
authors.lastname: Yang
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D004431:Ear, External / Q000098:blood supply; D006801:Humans; D008297:Male; D008722:Methods; D008833:Microcirculation; D008953:Models, Anatomic; D009852:Omentum / Q000098:blood supply; D010413:Penis / Q000098:blood supply; D011140:Polyurethanes; D011474:Prosthesis Design; D012828:Silicones; D013552:Swine
chemical_list: D011140:Polyurethanes; D012828:Silicones