[Antiamnesic action of nomifensine].
Nomifensine efficiency in the improvement of memory trace restoration impaired by spontaneous forgetting or amnesic influence was demonstrated in experiments on BALB/c mice by using the passive avoidance technique. Doses of 10-20 mg/kg proved to be the most efficient. The presented results suggest that the antiamnesic effect of nomifensine is due to the activation of dopaminergic and noradrenergic systems.
Il'iuchenok
R Iu
RIu
Vinnitskiĭ
I M
IM
Dubrovina
N I
NI
D000647:Amnesia / Q000188:drug therapy*; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D004924:Escape Reaction / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009627:Nomifensine / Q000627:therapeutic use*; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D009627:Nomifensine
Antiamnezicheskoe deĭstvie nomifenzina.