title: Epidermal growth factor receptor immunoreactivity in rat brain astrocytes. Response to injury.
abstract: Brain astroglia in normal adult rats stained weakly or not at all with an antibody to epidermal growth factor receptor (EGFR). A dramatic change took place after injury. The astrocytes adjacent to an entorhinal ablation and in deafferented areas of the hippocampus showed prominent EGFR immunoreactivity. Cells that were EFGR-immunoreactive also stained intensely with an antibody to glial fibrillary acidic protein (GFAP). The localization and the time course of appearance of EGFR/GFAP immunoreactivity suggests that EGFR may be involved in the conversion of a normal into a reactive astrocyte.
authors.affiliation: Department of Psychobiology, University of California, Irvine 92717.
authors.forename: M
authors.initials: M
authors.lastname: Nieto-Sampedro
authors.forename: F
authors.initials: F
authors.lastname: Gómez-Pinilla
authors.forename: D J
authors.initials: DJ
authors.lastname: Knauer
authors.forename: J T
authors.initials: JT
authors.lastname: Broderick
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D066246:ErbB Receptors / Q000378:metabolism*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005904:Glial Fibrillary Acidic Protein; D066246:ErbB Receptors