title: Haloperidol blocks the conditioned place preferences induced by rewarding brain stimulation.
abstract: The conditioned place preference test was employed to investigate the effects of neuroleptic challenge on the rewarding properties of lateral hypothalamic stimulation. Conditioning took place during a single day and consisted of five 5-min exposures to each of two environments (differing in color and floor texture). Twenty-four hours later, when provided a choice between the two environments, rats showed strong preferences for the environment in which they had experienced sessions of rewarding brain stimulation. These stimulation-produced place preferences were prevented by pretreatment with the neuroleptic drug, haloperidol (0.3 but not 0.15 mg/kg, ip). On the basis of these results, it was concluded that (a) the conditioned place preference test can provide a rate-free index of brain stimulation reward and (b) dopamine receptor antagonism can result in an attenuation of the rewarding properties of lateral hypothalamic stimulation.
authors.affiliation: Department of Psychology, University of California, Santa Barbara 93106.
authors.forename: A
authors.initials: A
authors.lastname: Ettenberg
authors.forename: C L
authors.initials: CL
authors.lastname: Duvauchelle
mesh_terms: D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology*; D007026:Hypothalamic Area, Lateral / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012201:Reward; D012653:Self Stimulation / Q000187:drug effects*
chemical_list: D006220:Haloperidol