[Effect of anabol on the functional activity indices of mononuclear phagocytes].
Anabol is a biopolymer from the complex of components extracted from the surface layer of the Lactobacillus bulgaricus cell wall. Its effect on certain indices of the functional activity of mononuclear phagocytes was studied. Administration of the preparation in a dose of 20 mg/kg 24 hours before the investigation resulted in lowering of the stain half-life in the general blood flow and increasing of the fibronectin levels in blood plasma of rats. Activation of the metabolic activity estimated by nitroblue tetrazolium test as well as resident cells and induced macrophages was observed. 24 hours after the anabol administration there was noted a marked increase in the pool of the precursors of granulocytes and macrophages, the stimulating effect being preserved for up to 3 days. The results showed that anabol had an effect on various elements of the system of mononuclear phagocytes. It may be useful in complex therapy aimed at increasing the host resistance to diverse toxic substances and bacterial infection.
Khlopovskaia
E I
EI
Chureeva
L N
LN
Chernysheva
N M
NM
Kaplan
V P
VP
Ogarkov
V I
VI
D000818:Animals; D001688:Biological Products / Q000494:pharmacology*; D001854:Bone Marrow Cells; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D005353:Fibronectins / Q000097:blood; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects; D007778:Lactobacillus; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009000:Monocytes / Q000187:drug effects* / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001688:Biological Products; D005353:Fibronectins; C055313:anabol
Vliianie anabola na nekotorye pokazateli funktsional'noĭ aktivnosti mononuklearnykh fagotsitov.