Allosteric behavior of artificial compounds.
The artificial allosteric molecules were prepared by connecting two independent metal porphyrin molecules by covalent bond. These molecules as fragments behave very similarly to the monomeric metal porphyrins except adsorption dissociation characteristics. In this paper we would like to discuss mostly on interesting and useful cooperativity or cooperative binding dissociation of small molecules like CO, O2, or base to both of porphyrin metals. The original structure of the dimeric porphyrin, especially when they are very strongly cooperative, usually needs chemical strain between two porphyrin rings and this strain is released by the first binding of small molecule which causes coordinating change of the metal porphyrin.
Tabushi
I
I
Department of Synthetic Chemistry, Faculty of Engineering, Kyoto University, Japan.
Kugimiya
S
S
D000494:Allosteric Regulation; D001802:Blood Substitutes; D002248:Carbon Monoxide / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D003035:Cobalt; D003432:Cross-Linking Reagents; D007093:Imidazoles; D007501:Iron; D009682:Magnetic Resonance Spectroscopy; D008665:Metalloporphyrins / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D011725:Pyridines; D015032:Zinc
D001802:Blood Substitutes; D003432:Cross-Linking Reagents; D007093:Imidazoles; D008665:Metalloporphyrins; D011725:Pyridines; D003035:Cobalt; C057524:4,4'-dipyridylmethane; D002248:Carbon Monoxide; C057523:N,N-diimidazoylmethane; D007501:Iron; D015032:Zinc; D010100:Oxygen