Gangliosides, or sialic acid, antagonize ethanol intoxication.
Because ethanol elicits a dose-dependent hydrolysis of brain sialogangliosides, we tested the possibility that injected gangliosides might antagonize intoxicating doses of ethanol. Clear anti-intoxication effects were seen at 24 hr post-injection of mixed mouse-brain gangliosides at 125-130 mg/kg, but not at lower or higher doses. Sleep time was reduced on the order of 50%, and roto-rod agility was significantly enhanced. Sialic acid (SA) similarly antagonized ethanol; however, the precursor of SA, N-acetyl-D-mannosamine, as well as ceramide and asialoganglioside did not.
Klemm
W R
WR
Department of Veterinary Anatomy, Texas A&M University, College Station 77843.
Boyles
R
R
Mathew
J
J
Cherian
L
L
D000427:Alcohol Deterrents; D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity*; D005677:G(M1) Ganglioside / Q000494:pharmacology; D005732:Gangliosides / Q000494:pharmacology*; D007700:Kinetics; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D019158:N-Acetylneuraminic Acid; D012794:Sialic Acids / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects
D000427:Alcohol Deterrents; D005732:Gangliosides; D012794:Sialic Acids; D005677:G(M1) Ganglioside; D000431:Ethanol; D019158:N-Acetylneuraminic Acid