Bilateral femoral head dysplasia and osteochondritis. Multiple epiphyseal dysplasia tarda, spondylo-epiphyseal dysplasia tarda, and bilateral Legg-Perthes disease.
Multiple epiphyseal dysplasia tarda (MEDT) and spondylo-epiphyseal dysplasia tarda (SEDT) are genetically transmitted conditions affecting the hips, which may resemble bilateral Legg-Perthes disease (LPD). Misdiagnoses are not uncommon, with serious implications for treatment, prognosis and genetic counseling. An epidemiologic study of MEDT and SEDT in a well-defined population of 453,921 persons in Denmark was performed. A population prevalence of 0.7 per 100,000 inhabitants with SEDT and 4.0 per 100,000 inhabitants with MEDT was found. Distinguishing features between MEDT, SEDT and bilateral LPD based on radiologic findings in the hips, other joints, and spine were ascertained. Bilateral LPD is always asymmetric, exhibits patches of increased density in the epiphyses and often metaphyseal cyst-like changes. No spinal lesion or affection of other joints is present, and the acetabula are normal. In MEDT and SEDT the capital femoral epiphyses are symmetrically flattened, fragmented and uniformly slightly sclerotic. Generalised platyspondyly is a constant finding in SEDT.
Andersen
P E
PE
Department of Diagnostic Radiology, Odense University Hospital, Denmark.
Schantz
K
K
Bollerslev
J
J
Justesen
P
P
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003718:Denmark; D003937:Diagnosis, Differential; D005271:Femur Head Necrosis / Q000000981:diagnostic imaging*; D006801:Humans; D007873:Legg-Calve-Perthes Disease / Q000000981:diagnostic imaging*; D010009:Osteochondrodysplasias / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000235:genetics; D011859:Radiography; D012042:Registries