[Effect of serotonin on the myoelectrical activity of the body of the stomach, the pyloric sphincter and duodenum].
8-10 mg/kg serotonin augmented the AP amplitude in the duodenum and reduced it in the stomach and pyloric sphincter in rabbits, the burst frequency in the duodenum smooth muscles being much higher than in the latters. The amount of APs in each burst increased after serotonin administration in the duodenum and decreased in the stomach and pyloric sphincter, the activating effect of serotonin on the duodenum smooth muscles preceding its inhibitory effect on the latter's smooth muscles. The higher sensitivity to serotonin seems to be due to a higher concentration of endogenous serotonin in the duodenum tissue.
Shemerovskiĭ
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KA
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003404:Creatinine / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D004386:Duodenum / Q000187:drug effects / Q000502:physiology; D004567:Electrodes, Implanted; D004576:Electromyography; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D011708:Pylorus / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology* / Q000502:physiology; D013270:Stomach / Q000187:drug effects / Q000502:physiology
D004338:Drug Combinations; C014050:creatinine sulfate, serotonin drug combination; D012701:Serotonin; D003404:Creatinine
Vliianie serotonina na mioélektricheskuiu aktivnost' tela zheludka, piloricheskogo sfinktera i dvenadtsatiperstnoĭ kishki.