title: Intraoral mucosal reconstruction with microvascular free jejunal autografts: an experimental study.
abstract: This experimental study investigated the problem of covering bare bone adequately in the oral cavity to provide a stable, functionally acceptable reconstruction. In eight dogs, intraoral mucosal defects were created whilst preserving the mandibular arch. The defects were reconstructed with a microvascular jejunal patch. Six animals had their reconstructions stressed postoperatively by the administration of irradiation and by feeding solid food. Two control dogs did not receive irradiation. Grafts were assessed clinically and histologically for 6 months. Rapid mucosal healing occurred in seven of eight dogs. The grafts conformed well to the mandibular contour and were tolerant of postoperative radiotherapy and the chewing of solid food. Structural integrity of seven grafts was maintained although subtotal villous atrophy occurred in irradiated grafts and to a lesser extent in control grafts. In one animal whose graft mucosa sloughed, the wound was re-epithelialized from the adjacent buccal mucosa. Microvascular jejunal patches therefore provided a durable, functionally adequate reconstruction of the mouth floor.
authors.affiliation: Microsurgery Research Centre, St Vincent's Hospital, Melbourne, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Sheen
authors.forename: G M
authors.initials: GM
authors.lastname: Mitchell
authors.forename: A M
authors.initials: AM
authors.lastname: MacLeod
authors.forename: B M
authors.initials: BM
authors.lastname: O'Brien
mesh_terms: D000818:Animals; D004285:Dogs; D006085:Graft Survival; D007583:Jejunum / Q000473:pathology / Q000528:radiation effects / Q000637:transplantation*; D009061:Mouth Mucosa / Q000601:surgery*; D011184:Postoperative Period