Testosterone therapy in young and old rhesus males that display low levels of sexual activity.
Ten wild-born rhesus (Macaca mulatta) males (estimated age, 14-28 years) were given pair-tests with each of six sexually receptive females. Males that ejaculated in 50% or less of the tests (N = 5) were assigned to an experimental group and those that ejaculated in over 50% of the tests (N = 5) served as a control group. All of the males had typically ejaculated in over 80% of the pair tests given in the past. The experimental group was injected daily with testosterone propionate (TP, 1 mg/kg) and was given a pair-test twice each week for six weeks. The control group was injected daily with oil and given comparable tests with the same females. Treatment with TP did not increase level of performance, and differences between the groups, overall, showed little change. In a second experiment five wild-born males (three, 7-9 years; two, 17 years) whose previous sexual performance had characteristically been sluggish were given two pre- and two posttests with each of five receptive females. They were given the same TP treatment as were the males in the first experiment. Treatment with TP failed to improve performance.
Phoenix
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Oregon Regional Primate Research Center, Beaverton 97006.
Chambers
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D000375:Aging / Q000187:drug effects*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004542:Ejaculation / Q000187:drug effects; D008253:Macaca mulatta; D008297:Male; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000008:administration & dosage* / Q000097:blood
D013739:Testosterone