Opening of coronary collaterals by repeated brief coronary occlusions in conscious dogs.
The collateral blood flow and regional myocardial function during a one-minute coronary occlusion were compared before and after multiple one-minute coronary occlusions. After repeated coronary occlusions, the collateral blood flow velocity increased significantly from 0.7 +/- 0.1 (SE) to 2.0 +/- 0.2 cm/sec (p less than 0.05), and the blood flow debt repayment decreased from 326 +/- 26% to 189 +/- 12% (p less than 0.05). The systolic segment shortening in the collateral dependent zone improved slightly. Thus, the native coronary collateral vessels open in response to a repeated ischemic stimulus.
Fujita
M
M
Dalton Research Center, University of Missouri-Columbia.
McKown
D P
DP
McKown
M D
MD
Franklin
D
D
D000818:Animals; D003097:Collateral Circulation; D003243:Consciousness; D003250:Constriction; D003326:Coronary Circulation; D003327:Coronary Disease / Q000503:physiopathology*; D003331:Coronary Vessels / Q000502:physiology*; D004285:Dogs; D009200:Myocardial Contraction; D013997:Time Factors