Platelet transfusion refractoriness associated with two rare platelet-specific alloantibodies (anti-Baka and anti-PlA2) and multiple HLA antibodies.
A 65-year-old patient with pancytopenia resulting from osteomyelosclerosis became refractory to platelet transfusions during long-time transfusion support. He developed two rare, platelet-specific antibodies (anti-PlA2 and -Baka) disguised by strong, multispecific HLA antibodies. The specificity of the platelet-specific antibodies was detected by a newly designed enzyme-linked immunosorbent assay using glycoprotein-specific monoclonal antibodies for immobilization of platelet antigens.
Langenscheidt
F
F
Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, FRG.
Kiefel
V
V
Santoso
S
S
Mueller-Eckhardt
C
C
D000368:Aged; D016824:Antigens, Human Platelet; D000961:Antilymphocyte Serum / Q000302:isolation & purification; D006680:HLA Antigens / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D039661:Integrin beta3; D007518:Isoantibodies / Q000302:isolation & purification; D007519:Isoantigens / Q000276:immunology*; D008297:Male; D017713:Platelet Transfusion; D012189:Retrospective Studies; D065227:Transfusion Reaction
C044561:3a alloantigen, human; D016824:Antigens, Human Platelet; D000961:Antilymphocyte Serum; D006680:HLA Antigens; C061248:ITGB3 protein, human; D039661:Integrin beta3; D007518:Isoantibodies; D007519:Isoantigens