Nonselective and selective methods for biological monitoring of exposure to coal-tar products.
Biological monitoring of exposure to coal-tar products has been carried out using the nonselective urinary mutagenicity and thioether assays and a selective method for the detection of 1-hydroxypyrene in urine. The sensitivities of the three methods have been compared. In several work environments, no increase that could be related to exposure to coal-tar products was found with the nonselective methods, whereas the levels of 1-hydroxypyrene in urine were enhanced. The applicability of the method for the detection of 1-hydroxypyrene in urine is further demonstrated.
Bos
R P
RP
Department of Toxicology, Faculty of Medicine, University of Nijmegen, The Netherlands.
Jongeneelen
F J
FJ
D003033:Coal Tar / Q000378:metabolism*; D003877:Dermatitis, Contact / Q000188:drug therapy; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods*; D005260:Female; D006801:Humans; D009152:Mutagenicity Tests; D011721:Pyrenes / Q000652:urine; D013438:Sulfhydryl Compounds / Q000032:analysis
D011721:Pyrenes; D013438:Sulfhydryl Compounds; D003033:Coal Tar; C033146:1-hydroxypyrene