Effect of subacute dosage of fluoride on male mice.
A sublethal concentration (one-tenth of the LD50) of fluoride (F) (5.2 mg F/kg body weight) was administered to Swiss albino mice (male) daily for 35 days. These mice showed a decrease in body weight gain, and food and water consumption. A significant decrease in red blood cell counts and an increase in white blood cell counts were seen in fluoride-administered mice. These animals also showed a decline in albumin, total protein, cholesterol, glucose and alkaline phosphatase activity in the serum. The fluoride content significantly increased in different organs of these animals. Sperm did not show any abnormalities due to fluoride toxicity.
Pillai
K S
KS
Jai Research Foundation, Dist Bulsar, Gujarat, India.
Mathai
A T
AT
Deshmukh
P B
PB
D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D013094:Spermatozoa / Q000187:drug effects; D014018:Tissue Distribution
D012969:Sodium Fluoride