title: [Endocrine function and African trypanosomiasis. Evaluation of 79 cases].
abstract: Although the high frequency of hypogonadism was found during the sleeping sickness, the physiological properties of the gonads have been poorly studied. We reported here the exploration of the gonadotropic axis in 79 patients infected by Trypanosoma brucei gambiense. It has been noted a decrease in oestradiol for 50% of women, in testosterone levels for 50% of men whereas no decrease of pituitary gonadotropins (FSH and LH) was found. The results of the gonad adenohypophyseal tests suggested that the dysfunction may be of central origin. The studies of thyreotropic axis were also examined: a decrease in T3 and FT3 (free fraction) even though T4 was normal. The specific relationship between hypogonadism and trypanosomal infection is discussed in this report.
authors.affiliation: Unité INSERM n. 16, Lille.
authors.forename: M
authors.initials: M
authors.lastname: Hublart
authors.forename: L
authors.initials: L
authors.lastname: Lagouche
authors.forename: A
authors.initials: A
authors.lastname: Racadot
authors.forename: A
authors.initials: A
authors.lastname: Boersma
authors.forename: P
authors.initials: P
authors.lastname: Degand
authors.forename: F
authors.initials: F
authors.lastname: Noireau
authors.forename: J L
authors.initials: JL
authors.lastname: Lemesre
authors.forename: A
authors.initials: A
authors.lastname: Toudic
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D005260:Female; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis / Q000209:etiology*; D007037:Hypothyroidism / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D014347:Trypanosoma brucei gambiense; D014353:Trypanosomiasis, African / Q000150:complications* / Q000175:diagnosis
vernacular_title: Fonction endocrine et trypanosomiase africaine. Bilan de 79 cas.