Novel compositions of emulsified perfluorochemicals for biological uses.
Physico-chemical characteristics of novel perfluorodecalin emulsions stabilized against Ostwald ripening by the addition of polycyclic, perfluorinated oil additives are described. The effects of varying both oil additive and emulsifier concentrations have been examined. Stabilizing effects of additives were found to be related to molecular weight and hence, boiling point and vapour pressure.
Sharma
S K
SK
Department of Pharmacy, University of Nottingham, University Park, U.K.
Lowe
K C
KC
Davis
S S
SS
D001802:Blood Substitutes; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004355:Drug Stability; D004655:Emulsions; D005079:Excipients; D005449:Fluorenes; D005466:Fluorocarbons; D006358:Hot Temperature; D008970:Molecular Weight; D011060:Poloxalene
D001802:Blood Substitutes; D004655:Emulsions; D005079:Excipients; D005449:Fluorenes; D005466:Fluorocarbons; C008805:perfluorodecalin; C057575:perfluoroperhydrofluoranthene; D011060:Poloxalene