title: Radiotherapy in the management of vaginal intraepithelial neoplasia after hysterectomy.
abstract: Intravaginal radium was used to treat 11 patients who were found to have vaginal intraepithelial neoplasia (VAIN) following hysterectomy for cervical intraepithelial neoplasia. All were discovered by cytological follow-up, were colposcopically assessed and diagnosis was confirmed by histological examination before treatment. Nine of 10 patients questioned continue to enjoy satisfactory sexual intercourse after treatment but 6 of 8 premenopausal patients subsequently became oestrogen deficient and required hormone replacement therapy. No other significant morbidity has been observed. All remain cytologically and colposcopically free of disease after a median follow-up of 26 months. We conclude that radiotherapy is an effective treatment of VAIN following hysterectomy.
authors.affiliation: Birmingham and Midland Hospital for Women.
authors.forename: C B
authors.initials: CB
authors.lastname: Woodman
authors.forename: J J
authors.initials: JJ
authors.lastname: Mould
authors.forename: J A
authors.initials: JA
authors.lastname: Jordan
mesh_terms: D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D011183:Postoperative Complications / Q000532:radiotherapy*; D011446:Prospective Studies; D014625:Vaginal Neoplasms / Q000532:radiotherapy*