title: The effect of doxycycline on the intestinal alkaline phosphatase (EC 3.1.3.1) activity in rat. A quantitative study.
abstract: The doxycycline effect on the alkaline phosphatase activity in the small intestinal glandular epithelium in rat was examined, using the interferometric technique. The antibiotic caused a statistically significant fall of the alkaline phosphatase activity and the enzyme was found to decrease with consecutive doses of the drug.
authors.affiliation: Department of Pharmacodynamics, Academy of Medicine, Warszawa, Poland.
authors.forename: I E
authors.initials: IE
authors.lastname: Wiśniewska
authors.forename: Z
authors.initials: Z
authors.lastname: Gawlik
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D002130:Calcium Phosphates / Q000378:metabolism; D004318:Doxycycline / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000378:metabolism; D007583:Jejunum / Q000201:enzymology*; D008297:Male; D051381:Rats
chemical_list: D002130:Calcium Phosphates; D000469:Alkaline Phosphatase; D004318:Doxycycline