title: Erectile responses to intracavernous papaverine and phentolamine: comparison of single and combined delivery.
abstract: In a prospective study of 15 consecutive impotent patients we evaluated the erectile responses to intracavernous injections of standardized doses of papaverine and phentolamine alone and in combination. Of the 15 patients 13 achieved a full erection with the drug combination, whereas only 6 achieved a full erection with papaverine and 1 with phentolamine. Our results suggest an effective alternative to the use of papaverine alone, whose long-term sequelae have been shown to be deleterious.
authors.affiliation: Department of Urology, University Clinics, Freiburg, West Germany.
authors.forename: C G
authors.initials: CG
authors.lastname: Stief
authors.forename: U
authors.initials: U
authors.lastname: Wetterauer
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D007267:Injections / Q000379:methods; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000008:administration & dosage / Q000627:therapeutic use*; D010413:Penis / Q000098:blood supply; D010646:Phentolamine / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies
chemical_list: D010208:Papaverine; D010646:Phentolamine