[Hereditary neuropathy with recurrent mononeuropathy (tomaculous neuropathy)].
Clinical and neurophysiological studies were carried out in 15 members out of 5 families affected by recurrent peripheral nerve and brachial plexus palsies. Nerve biopsy showed typical "tomacula". While in 3 families a slight development of the symptomatology was observed in the other 2 families there was an evolution toward a severe symmetric neuropathy. Motor and sensory conduction velocity were, in some cases, slowed even in clinically unaffected nerves. Electrophysiological changes were more important at entrapment sites. Such abnormalities could be found also in unaffected family members.
Serena
M
M
Reparto di Neurologia, Ospedale Civile Regionale, Treviso.
Bardin
P G
PG
D000328:Adult; D001706:Biopsy; D005260:Female; D005799:Genes, Dominant; D015417:Hereditary Sensory and Motor Neuropathy / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D010375:Pedigree; D010525:Peripheral Nerves / Q000503:physiopathology / Q000648:ultrastructure; D012008:Recurrence
Neuropatia ereditaria con mononeuropatie ricorrenti ("tomaculous" neuropathy).