Growth and metastasis of Lewis lung carcinoma in the footpad of mice.
When Lewis lung carcinoma cells were transplanted into the footpad of mice, exponential growth of tumour was seen from the 4th day. Intravasation of tumour cells was first seen at this time, then increased steadily up to the 10th day. Tumour cells entered the circulation by destructive degeneration of the vascular endothelium and also by transcellular passage, mainly through capillaries, venules and thin-walled tumour vascular channels. Multiple sites of entry of tumour cells into the circulation were frequently found. The rate of intravasation of tumour cells into the circulation was the same at the proximal, middle and distal portions of the tumour.
Kitinya
J N
JN
Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Kinjo
M
M
Tanaka
K
K
D000818:Animals; D001808:Blood Vessels / Q000473:pathology; D002277:Carcinoma / Q000098:blood supply / Q000473:pathology* / Q000556:secondary; D004730:Endothelium, Vascular / Q000473:pathology; D005528:Foot; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D009360:Neoplastic Cells, Circulating