Action and interaction of two alpha 1-adrenoceptor agonists, methoxamine and St 587, on the rabbit's blood pressure and EEG.
In rabbits methoxamine reversed the vasopressor effect of St 587 and abolished the EEG synchronizing action of St 587. The interaction on the blood pressure could be ascribed either to the different chemical structures of St 587 and methoxamine or to partial agonistic properties of St 587. The interaction on the EEG appears to be more complex.
Pichler
L
L
Ernst Boehringer-Institut für Arzneimittelforschung, Bender & Co GmbH, Vienna, Austria.
Stumpf
C
C
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D003000:Clonidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004347:Drug Interactions; D004569:Electroencephalography; D005260:Female; D008297:Male; D008729:Methoxamine / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits
C030655:St 587; D008729:Methoxamine; D003000:Clonidine