title: Periampullary, colorectal and gastric cancer in two siblings.
abstract: We describe a sibship affected by subsequent periampullary, colorectal and gastric carcinoma. Three of 4 siblings (2 males, 1 female) developed a periampullary carcinoma at the age of 20, and the 2 brothers subsequently had colorectal and gastric carcinoma. One of them also had familial adenomatous polyposis. There is suggestive evidence of vertical transmission of a gene predisposing to a hereditary colorectal carcinoma syndrome.
authors.affiliation: Chirurgische Abteilung, Stadtspital Waid, Zürich, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Schlossberg
authors.forename: W
authors.initials: W
authors.lastname: Weber
authors.forename: U
authors.initials: U
authors.lastname: Stoffel
authors.forename: K
authors.initials: K
authors.lastname: Henggeler
authors.forename: H
authors.initials: H
authors.lastname: Stocker
authors.forename: M
authors.initials: M
authors.lastname: Foeppl
authors.forename: A
authors.initials: A
authors.lastname: Akovbiantz
mesh_terms: D000328:Adult; D014670:Ampulla of Vater; D015179:Colorectal Neoplasms / Q000235:genetics*; D003138:Common Bile Duct Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics*