title: Cisplatin as first-line therapy for metastatic breast cancer.
abstract: Cisplatin has had only minimal activity when used as second- and third-line chemotherapy for metastatic breast cancer (MBC). There have been no phase II studies in the United States evaluating cisplatin in patients with MBC with no prior chemotherapy. We therefore treated 20 consecutive patients with cisplatin 30 mg/m2/d for four days every 3 weeks for a maximum of six courses. We obtained partial responses in nine of 19 evaluable patients (47%), with responses in liver, lung, and soft tissue indicator lesions. Our data suggest that cisplatin has substantial single-agent activity as front-line therapy in MBC, and should be considered for inclusion in first-line combination chemotherapy regimens.
authors.affiliation: Department of Medicine, Indiana University School of Medicine, Indianapolis.
authors.forename: G W
authors.initials: GW
authors.lastname: Sledge
authors.forename: P J
authors.initials: PJ
authors.lastname: Loehrer
authors.forename: B J
authors.initials: BJ
authors.lastname: Roth
authors.forename: L H
authors.initials: LH
authors.lastname: Einhorn
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy*; D002945:Cisplatin / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008875:Middle Aged
chemical_list: D002945:Cisplatin