[Modification of the effect of fotrin in phenobarbital-induced metabolic system].
Random bred male rats were given drinking water with phenobarbital (PB) (daily doses 0.4; 2 and 10 mg/kg) during 120 days. Activity of mixed function of oxygenases (content of cytochromes P-450) were enhanced after PB treatment in doses 2 and 10 mg/kg. Following PB treatment the animals were injected 5-times ethyleneimine derivate--fotrin at the doses 2, 4 and 7 mg/kg. The induction of mixed function of oxygenases resulted in significant decrease in the number of cells with chromosome aberrations.
Zhurkov
V S
VS
Sycheva
L P
LP
Burmantova
N P
NP
D000818:Animals; D001388:Aziridines / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002869:Chromosome Aberrations; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004790:Enzyme Induction / Q000187:drug effects; D008297:Male; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D009153:Mutagens / Q000494:pharmacology*; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats
D001388:Aziridines; D001389:Azirines; D009153:Mutagens; C007779:fotrin; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010634:Phenobarbital
Modifikatsiia éffekta fotrina na fone induktsii sistemy metabolizma fenobarbitalom.