The effects of concanavalin A on milk secretion and mammary metabolism in the goat.
The effects of concanavalin A on the rate of milk secretion and the concentration of metabolites in milk were studied following intramammary injection of the lectin via the teat canal into one mammary gland of lactating goats. Concanavalin A decreased milk secretion from the treated gland, reduced the concentrations of phosphoenolpyruvate, nucleoside diphosphate and 2-oxoglutarate in milk and increased the concentrations of glucose, galactose, glycerol, L-lactate, pyruvate, isocitrate and citrate. The changes in the concentrations of the metabolites in milk are discussed in relation to biochemical changes occurring in the mammary gland during the suppression of milk secretion. It is suggested that, when lactose synthesis and secretion is decreased, substantial metabolism of glucose via glycolysis occurs.
Faulkner
A
A
Hannah Research Institute, Ayr, U.K.
Pollock
H T
HT
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology*; D005089:Exocytosis / Q000187:drug effects; D005260:Female; D006041:Goats; D007656:Ketoglutaric Acids / Q000378:metabolism; D007774:Lactation / Q000187:drug effects*; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000378:metabolism; D010728:Phosphoenolpyruvate / Q000378:metabolism; D011247:Pregnancy
D007656:Ketoglutaric Acids; D003208:Concanavalin A; D010728:Phosphoenolpyruvate