Hybrid resistance to parental bone marrow-derived cultured mast cells in the skin but not in the peritoneal cavity of (WB X C57BL/6)F1-W/Wv mice.
When cultured mast cells of (WB X C57BL/6)F1-+/+(WBB6F1-+/+) and WB-+/+(WB) mice were directly injected into the skin of genetically mast cell-deficient WBB6F1-W/Wv mice, mast cell clusters appeared at the injection sites. Although in vitro colony-forming ability is comparable between cultured mast cells of WB mice and those of WBB6F1-+/+ mice, the number of WB mast cells necessary for the appearance of mast cell clusters in the skin of WBB6F1-W/Wv mice was significantly larger than the number of WBB6F1-+/+ mast cells. In spite of the presence of such an apparent hybrid resistance in the skin of WBB6F1-W/Wv mice to mast cells of the WB parent, both WB and WBB6F1-+/+ mast cells grow in the peritoneal cavity of WBB6F1-W/Wv mice with comparable efficiency. This is a demonstration of the tissue-related (nonrecirculating) expression of hybrid resistance against nonmalignant hematopoietic cells.
Nakano
T
T
Division of Cancer Pathology, Osaka University Medical School, Japan.
Waki
N
N
Kanakura
Y
Y
Fujita
J
J
Sonoda
S
S
Asai
H
H
Kitamura
Y
Y
D000818:Animals; D001854:Bone Marrow Cells; D003433:Crosses, Genetic; D006084:Graft Rejection; D006822:Hybrid Cells; D008407:Mast Cells / Q000637:transplantation*; D051379:Mice; D008815:Mice, Inbred Strains