Changes of contact phase proteins during haemodialysis.
Functional and immunological activities of factors XII and XI, Prekallikrein, high molecular weight kininogen and C-1-esterase inhibitor were studied in eight patients before, during and after haemodialysis. During and after dialysis sessions a significant decrease in the functional activities of Prekallikrein and high molecular weight kininogen (p less than 0.05) could be detected, whereas their immunological levels did not change. Furthermore C-1-esterase inhibitor increased after dialysis (p less than 0.05). These results indicate activation of the kinin system during haemodialysis.
Vicente
V
V
Division of Haematology, University Hospital, Salamanca, Spain.
Alegre
A
A
Alberca
I
I
Lopez Borrasca
A
A
Gomez
J R
JR
Macias
J F
JF
D000328:Adult; D000368:Aged; D001780:Blood Coagulation Tests; D001798:Blood Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*
D001798:Blood Proteins