title: Interaction between luteotrophic hormone (LH) and thymosin on natural killer cell activity in BALB/c mice.
abstract: The present study investigates the effect of a pituitary hormone (luteotrophic hormone, LH) and a thymic factor (thymosin fraction V, TVF) on in vitro and in vivo natural killer (NK) cell activity of BALB/c mice (2, 6 and 8 months old). In vitro it was found that LH at various concentrations (0.5, 5, 50 and 500 ng/ml) significantly reduced the NK cell activity. This inhibition was not blocked by TFV. In vivo it was observed that there was a great inhibition of NK cell activity by LH (5 and 50 ng/ml) on 2- and 6-month-old mice, but a significant increase of NK cell activity on 8-month-old mice. The physiological significance of these observations points to an intimate connection between immune and endocrine system functions.
authors.affiliation: Laboratory of Animal Physiology General and Comparative Immunology, Limoges, France.
authors.forename: M
authors.initials: M
authors.lastname: Rouabhia
authors.forename: Z
authors.initials: Z
authors.lastname: Ghanmi
authors.forename: P A
authors.initials: PA
authors.lastname: Deschaux
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D004306:Dose-Response Relationship, Immunologic; D004347:Drug Interactions; D007694:Killer Cells, Natural / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology; D013947:Thymosin / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: C033782:thymosin fraction 5; D013947:Thymosin; D007986:Luteinizing Hormone