[Effect of a new antiviral compound 1-morpholinomethyltetrahydro-2(1H)-pyrimidinone on the interaction of influenza virus proteins with flat lipid membranes].
The antiviral preparation 1-morpholinomethyltetrahydro-2(1H)-pyrimidinone (abbreviation DD-13) inhibiting reproduction of certain enveloped viruses belonging to groups of orthomyxoviruses and alphaviruses, influenza type A viruses among them, inhibited adsorption and insertion of influenza virus M protein into model bilayer lipid membranes. The preparation did not interact directly with lipid bilayers but, after pretreatment of M protein with it, inhibited M protein interaction with the membranes: adsorption and insertion into the bilayer DD-13 did not affect the interaction of influenza virus surface glycoproteins with the model lipid membranes. It is concluded that the DD-13 preparation, not interacting with the membranes directly, in native systems may modify the protein-lipid interactions at the stages of virus penetration into the cell, penetration of M protein-coated nucleocapsid into the cell nucleus through the nuclear membrane, as well as at the stage of virus particle assembly on the plasma membrane of the infected cell.
Tverdislov
V A
VA
Kharitonenkov
I G
IG
Sukhanov
S V
SV
Galabov
A S
AS
D000327:Adsorption; D000998:Antiviral Agents / Q000494:pharmacology*; D004347:Drug Interactions; D066298:In Vitro Techniques; D009980:Influenza A virus; D008051:Lipid Bilayers / Q000494:pharmacology*; D011744:Pyrimidinones / Q000494:pharmacology*; D013499:Surface Properties; D014763:Viral Matrix Proteins / Q000494:pharmacology*
D000998:Antiviral Agents; D008051:Lipid Bilayers; C031540:M-protein, influenza virus; D011744:Pyrimidinones; D014763:Viral Matrix Proteins; C047314:1-morpholinomethyl-tetrahydro-1(1H)-pyrimidinone
O vliianii novogo protivovurusnogo soedineniia 1-morfolinometiltetragidro-2(1H)-pirimidinona na vzaimodeĭstvie belkov virusa grippa s ploskimi lipidnymi membranami.