The effect of a bradykinin antagonist on vasodilator responses with particular reference to the submandibular gland of the cat.
A bradykinin analogue, D-Arg[Hyp3, Thi5,8, D-Phe7]-Bk, antagonized the vasodilator effect of bradykinin injected close-arterially in the submandibular salivary gland of the cat, without affecting that due to acetylcholine or nerve stimulation. The same analogue also antagonized the hypotensive response to bradykinin injected intravenously in cats and rabbits. We conclude that functional hyperaemia in the submandibular gland of the cat is not due to the release of bradykinin by salivary kallikrein.
Barton
S
S
Department of Physiology, University of Alberta, Edmonton, Canada.
Karpinski
E
E
Schachter
M
M
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D002415:Cats; D004558:Electric Stimulation; D005260:Female; D008297:Male; D010275:Parasympathetic Nervous System / Q000502:physiology; D013363:Submandibular Gland / Q000098:blood supply* / Q000294:innervation; D014664:Vasodilation / Q000187:drug effects*
C053748:B 4162; D001920:Bradykinin