Lipid antioxidant properties of quercetin in vitro.
The effect of quercetin on iron-catalyzed hepatic microsomal lipid peroxidation was investigated. Quercetin was shown to be a potent inhibitor of iron-induced lipid peroxidation with a I50 of 0.2 mM. The inhibitory effects of quercetin were dependent on incubation time, protein concentration and iron content in the incubation mixture. Since quercetin does not interact with malonyl-aldehyde it can be concluded that the inhibition of iron induced lipid peroxidation is due to lipid antioxidant property and this may serve as a model for the study by which "free" iron may initiate peroxidation in vivo.
Das
M
M
Industrial Toxicology Research Centre, Lucknow, India.
Ray
P K
PK
D000818:Animals; D000975:Antioxidants; D005419:Flavonoids / Q000494:pharmacology*; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats
D000975:Antioxidants; D005419:Flavonoids; D008054:Lipid Peroxides; D011506:Proteins; D011794:Quercetin; D007501:Iron