title: Corpus callosotomy for the treatment of intractable epilepsy.
abstract: Twenty-five patients underwent anterior corpus callosotomy (ACC) for treatment of uncontrolled seizures. Two patients died, and 6 patients experienced perioperative complications which resolved. A statistically significant reduction of generalized tonic-clonic seizures (17 patients; P less than 0.05) and complex partial seizures (11 patients; P less than 0.05) occurred following ACC. A single patient with atonic seizures became free of atonic seizures. Two patients had a greater than 50% reduction in seizures resulting in falls, a single patient became free of episodes of status epilepticus, and in 2 patients the seizures changed from generalized tonic-clonic seizures to hemiconvulsive seizures. Thus ACC appears to decrease the severity and frequency of disabling seizures in some patients with uncontrolled seizures.
authors.affiliation: Department of Neurology, Medical College of Georgia, Augusta 30912.
authors.forename: A M
authors.initials: AM
authors.lastname: Murro
authors.forename: H F
authors.initials: HF
authors.lastname: Flanigin
authors.forename: B B
authors.initials: BB
authors.lastname: Gallagher
authors.forename: D W
authors.initials: DW
authors.lastname: King
authors.forename: J R
authors.initials: JR
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003337:Corpus Callosum / Q000503:physiopathology / Q000601:surgery*; D004569:Electroencephalography; D004827:Epilepsy / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D014057:Tomography, X-Ray Computed