title: [Chromosome analysis of ovocytes and human embryos collected after fertilization in vitro. A model of natural selection against aneuploidy].
abstract: Fertilization in-vitro offers the possibility of studying the karyotype of ovocytes obtained after superovulation, when they are not fertilized. Among 120 ovocytes, 30 p. cent presented a chromosomal anomaly. The same study was carried out on morphologically normal or abnormal embryos - and the percentage of chromosomal anomalies approximates here 27 p. cent. These studies offer a model of natural selection against chromosomal anomalies and confirm the limiting role of these anomalies in the success of FIV.
authors.affiliation: INSERM U.173, UA 119 CNRS, Laboratoire de Cytogénétique Humaine et Comparée, Hôpital Necker Enfants-Malades, Paris.
authors.forename: M
authors.initials: M
authors.lastname: Plachot
authors.forename: J
authors.initials: J
authors.lastname: De Grouchy
authors.forename: A M
authors.initials: AM
authors.lastname: Junca
authors.forename: J
authors.initials: J
authors.lastname: Mandelbaum
authors.forename: J
authors.initials: J
authors.lastname: Cohen
authors.forename: J
authors.initials: J
authors.lastname: Salat-Baroux
mesh_terms: D000782:Aneuploidy; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007621:Karyotyping; D009865:Oocytes; D012641:Selection, Genetic; D013480:Superovulation
vernacular_title: Analyse chromosomique des ovocytes et embryons humains obtenus après FIV. Modèle de sélection naturelle contre les aneuploïdies.