Delusional depression following benzodiazepine withdrawal.
Withdrawal from long-term treatment with benzodiazepines was followed in three patients by a severe delusional depression. The delusional depression may be related to the neurotransmitter changes accompanying benzodiazepine withdrawal. Caution should be exercised in long-term use of benzodiazepines in susceptible individuals.
Keshavan
M S
MS
Western Psychiatric Institute and Clinic, Pittsburgh, Pa.
Moodley
P
P
Eales
M
M
Joyce
E
E
Yeragani
V K
VK
D000328:Adult; D001008:Anxiety Disorders / Q000188:drug therapy*; D003702:Delusions / Q000139:chemically induced* / Q000523:psychology; D003866:Depressive Disorder / Q000139:chemically induced* / Q000523:psychology; D003975:Diazepam / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome / Q000523:psychology*
D008140:Lorazepam; D003975:Diazepam