Progesterone receptor heterogeneity and endometrial tumour differentiation.
Progesterone binding components were isolated using fast protein liquid chromatography (FPLC) with a recovery efficiency of between 60-70%. In normal uterine cytosol, the two components were in about equal proportions. In endometrial cancer, the ratio of peak size between peaks 1 and 2 was 1.5 for Grade I, 3.7 for Grade II and 2.5 for Grade III. Whether estimation of the levels of the two progesterone components separately would enhance predictability of response to hormone therapy in endometrial cancer remains to be established.
Cheng
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C
Department of Pathology, Royal Women's Hospital, Melbourne, Victoria, Australia.
Bui
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C
Cauchi
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M
D002454:Cell Differentiation; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D003600:Cytosol / Q000032:analysis; D005260:Female; D006801:Humans; D011282:Pregnenediones / Q000494:pharmacology; D011980:Receptors, Progesterone / Q000302:isolation & purification*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014594:Uterine Neoplasms / Q000032:analysis* / Q000473:pathology
D011282:Pregnenediones; D011980:Receptors, Progesterone; C020175:16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione