Renal effects of d-tubocurarine and pancuronium in the newborn rabbit.
The acute renal effects of d-tubocurarine and pancuronium were assessed in 14 anesthetized newborn rabbits. Glomerular filtration rate (GFR) and renal blood flow (RBF) were calculated from the inulin and p-aminohippuric acid clearances, respectively. Each animal acted as its own control. At doses used in human neonates, d-tubocurarine administration (0.80 mg/kg) produced a marked increase in renal vascular resistance (+123 +/- 62%) with a concomitant significant decrease in GFR (-35.4 +/- 12%) and RBF (-39 +/- 13%). Pancuronium administration (0.25 mg/kg) was associated with a nonsignificant decrease in GFR (-19 +/- 17%) and RBF (-20 +/- 12%) and an increase in renal vascular resistance (+66 +/- 52%). These results stress the need for careful monitoring of renal function in neonates receiving nondepolarizing muscle-relaxant agents.
Gouyon
J B
JB
Service de Pédiatrie, Centre Hospitalier Universitaire Vaudois, Lausanne, Suisse.
Torrado
A
A
Guignard
J P
JP
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000502:physiology; D010197:Pancuronium / Q000494:pharmacology*; D011817:Rabbits; D012079:Renal Circulation / Q000187:drug effects; D014403:Tubocurarine / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D010197:Pancuronium; D014403:Tubocurarine