title: Roxithromycin disposition in tonsils after single and repeated administrations.
abstract: Levels of roxithromycin in serum and tissue were investigated in 29 subjects undergoing tonsillectomy. A total of 13 subjects received a single oral dose of 300 mg, and 16 received four oral doses 12 h apart as follows: a 300-mg loading dose followed by three 150-mg doses. Measurable levels of roxithromycin were present in tonsil samples of 11 of 13 subjects in the first group. The mean levels in tonsils and serum were 0.8 microgram/g and 6.7 micrograms/ml, resulting in a mean tissue/serum ratio of 0.16. In the multiple-dose group, roxithromycin was found in 14 of 16 subjects at mean levels in tonsils and serum of 1.6 micrograms/g and 8.7 micrograms/ml, and the tissue/serum ratio was 0.23.
authors.affiliation: Clinical ORL Università di Pavia, Italy.
authors.forename: G B
authors.initials: GB
authors.lastname: Galioto
authors.forename: G
authors.initials: G
authors.lastname: Ortisi
authors.forename: E
authors.initials: E
authors.lastname: Mevio
authors.forename: D
authors.initials: D
authors.lastname: Sassella
authors.forename: F
authors.initials: F
authors.lastname: Bartucci
authors.forename: G
authors.initials: G
authors.lastname: Privitera
mesh_terms: D000293:Adolescent; D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007933:Leucomycins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D014066:Palatine Tonsil / Q000378:metabolism*
chemical_list: D007933:Leucomycins