A statistical model of the timing mechanism of the erythrocyte life-span.
Three statistical models are introduced as explanations of erythrocyte senescence. For the sake of simplicity, we prefer the multievent model, in which one of the parameters represents the number of events (between 7 and 12) needed to signal likely senescence. Proteolysis of a dimeric protein, such as protein 3, accounts for four events in the model, if little of the protein is degraded by senescence. Although each model we propose accommodates the possibility of random destruction, this alternative does not fit well with available experimental data.
Schell
M J
MJ
Department of Biostatistics and Information Systems, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.
Morrison
M
M
D001798:Blood Proteins / Q000378:metabolism; D004905:Erythrocyte Aging; D006801:Humans; D015233:Models, Statistical
D001798:Blood Proteins