The effect of photodynamic therapy (PDT) on glucose levels within the SMT-F mouse tumor.
Tumor glucose levels were assessed at various times following in vivo photodynamic therapy (PDT) and compared to levels following induction of anoxia in mice bearing the SMT-F tumor. Uptake of 2-deoxy-D glucose by isolated tumor cells was not altered following in vivo PDT. Tumor glucose levels following PDT were found to decline in a similar albeit slower manner to those found under anoxic conditions for 40 minutes and thereafter they declined at a greater rate. These results suggest an ischemic mechanism of tumor destruction characterized by the progressive development of stasis followed by hemorrhage resulting in the rapid depletion of extracellular glucose.
Musser
D A
DA
Department of Pathophysiology, Roswell Park Memorial Institute, Buffalo, NY 14263.
D000818:Animals; D003847:Deoxyglucose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D051379:Mice; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010100:Oxygen; D010778:Photochemotherapy
D003847:Deoxyglucose; D005947:Glucose; D010100:Oxygen