Inheritance of associated ocular and skeletal dysplasia in Labrador retrievers.
A breeding colony was established to investigate the inheritance of associated ocular and skeletal dysplasia in Labrador Retrievers; 124 pups were produced. These pups were evaluated for the presence of ocular lesions, including cataracts, vitreous strands, persistent hyaloid remnants, retinal folds, retinal dysplasia, peripapillary hyperreflectivity, and rhegmatogenous retinal detachments, and skeletal abnormality, which was recognized by shorter than normal forelimbs and an abnormal morphologic appearance of the radius and ulna. Analysis of the distribution of lesions in pups indicated that the syndrome is caused by one abnormal gene, which has recessive effects on the skeleton and incompletely dominant effects on the eye. This would suggest that suspect carrier dogs could be identified by test matings with a known homozygote.
Carrig
C B
CB
Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg 24061.
Sponenberg
D P
DP
Schmidt
G M
GM
Tvedten
H W
HW
D000818:Animals; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D004285:Dogs; D005128:Eye Diseases / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D005260:Female; D006618:Hip Dislocation, Congenital / Q000662:veterinary*; D006619:Hip Dysplasia, Canine / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics*; D008297:Male; D011859:Radiography; D012164:Retinal Diseases / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000662:veterinary; D013577:Syndrome / Q000662:veterinary