The effect of doxycycline on the intestinal alkaline phosphatase (EC 3.1.3.1) activity in rat. A quantitative study.
The doxycycline effect on the alkaline phosphatase activity in the small intestinal glandular epithelium in rat was examined, using the interferometric technique. The antibiotic caused a statistically significant fall of the alkaline phosphatase activity and the enzyme was found to decrease with consecutive doses of the drug.
Wiśniewska
I E
IE
Department of Pharmacodynamics, Academy of Medicine, Warszawa, Poland.
Gawlik
Z
Z
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D002130:Calcium Phosphates / Q000378:metabolism; D004318:Doxycycline / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000378:metabolism; D007583:Jejunum / Q000201:enzymology*; D008297:Male; D051381:Rats
D002130:Calcium Phosphates; D000469:Alkaline Phosphatase; D004318:Doxycycline