Glutamate decarboxylase-immunoreactive neurons in the aging rat hippocampus are more resistant to ischemia than CA1 pyramidal cells.
Glutamate decarboxylase (GAD)-immunoreactive, supposedly GABAergic inhibitory, neurons in various fields of the rat hippocampus and pyramidal cells in area CA1 were quantified 1 week after transient cerebral ischemia by 4-vessel occlusion. Whereas the number of CA1 pyramidal cells in Toluidine blue-stained semithin sections were found reduced by 50% when compared with controls there was no loss of GAD-immunoreactive cells in vibratome sections of hippocampus proper and fascia dentata. These data suggest that GABAergic hippocampal neurons are more resistant to ischemia than CA1 pyramidal cells.
Schlander
M
M
Institute of Anatomy, Johann Wolfgang Goethe University, Frankfurt/Main, F.R.G.
Hoyer
S
S
Frotscher
M
M
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002452:Cell Count; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D006624:Hippocampus / Q000201:enzymology / Q000503:physiopathology*; D007150:Immunohistochemistry; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D008297:Male; D009474:Neurons / Q000145:classification / Q000201:enzymology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D005968:Glutamate Decarboxylase