[Approaches to the analysis of reciprocal chromosome distribution in the bone marrow cells of mice].
A study was made of G-banding chromosome preparations made of bone marrow cells of BALB/c mouse females, injected intraperitoneally with a single dose of the antibiotic adriamycin 23 hours before sacrifice. Frequencies of different chromosome fusions in pericentromeric regions were analysed. All chromosomes were found to be involved in the interchromosomal associations, different chromosomes participating in such fusions with different frequency. No associations of homologous chromosomes were observed. For each chromosome a limited number of preferential partners for fusion was revealed, the number of such partners for different chromosomes varying. Almost for a half of chromosomes, chromosome 15 was one of the most preferred partners. Possible significance of the data obtained is discussed for the analysis of principles of the spatial chromosome arrangement in murine bone marrow cells.
Glazko
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D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure*; D002871:Chromosome Banding; D002875:Chromosomes / Q000187:drug effects / Q000648:ultrastructure*; D004317:Doxorubicin / Q000494:pharmacology; D005260:Female; D008677:Metaphase / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D014178:Translocation, Genetic / Q000187:drug effects
D004317:Doxorubicin
Podkhody k analizu vzaimnogo raspolozheniia khromosom v kletkakh kostnogo mozga mysheĭ.