title: Reversible cerebral lesions associated with tiazofurin usage: MR demonstration.
abstract: Tiazofurin is an experimental chemotherapeutic agent currently undergoing clinical evaluation. We report our results with magnetic resonance (MR) in demonstrating reversible cerebral abnormalities concurrent with the use of this drug. The abnormalities on MR were correlated with findings on CT as well as with cerebral angiography. The utility of MR in the evaluation of patients receiving this new agent is illustrated.
authors.affiliation: Department of Radiology, Indiana University School of Medicine, Indianapolis 46223.
authors.forename: D J
authors.initials: DJ
authors.lastname: Rippe
authors.forename: M K
authors.initials: MK
authors.lastname: Edwards
authors.forename: J F
authors.initials: JF
authors.lastname: Schrodt
authors.forename: J R
authors.initials: JR
authors.lastname: Bognanno
authors.forename: P G
authors.initials: PG
authors.lastname: D'Amour
authors.forename: O B
authors.initials: OB
authors.lastname: Boyko
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012254:Ribavirin / Q000009:adverse effects* / Q000031:analogs & derivatives; D012263:Ribonucleosides / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D012263:Ribonucleosides; D012254:Ribavirin; C033706:tiazofurin