title: Hypocholesterolemia in acute myelogenous leukemia.
abstract: Plasma-cholesterol concentrations were determined in 85 acute myelogenous leukemia patients. Measurements were repeated in 28 cases during remission. Mean plasma-cholesterol concentration (+/- SD) at diagnosis was 3.95 mmol/l (+/- 1.29). 47 patients (55.3%) had hypocholesterolemia (less than 3.87 mmol/l). Among the main clinical, hematologic and biochemical parameters, only high leukocyte counts were correlated with hypocholesterolemia. As far the FAB subtypes are concerned, the lowest cholesterol levels were observed in leukemias with monocytic component. However, although the same FAB subtypes showed significantly higher leucocytes counts than the other subtypes, both parameters were independently related to low cholesterol levels. Remission was associated with a significant increase in cholesterol levels in those patients with low cholesterol concentrations or high leukocyte counts at diagnosis. These results support the idea that initial hypocholesterolemia in acute myelogenous leukemia is related to the tumoral mass present at diagnosis.
authors.affiliation: Postgraduate School of Hematology Ferreras Valenti, Hospital Clinic, University of Barcelona, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Reverter
authors.forename: J
authors.initials: J
authors.lastname: Sierra
authors.forename: J M
authors.initials: JM
authors.lastname: Martí-Tutusaus
authors.forename: E
authors.initials: E
authors.lastname: Montserrat
authors.forename: A
authors.initials: A
authors.lastname: Grañena
authors.forename: C
authors.initials: C
authors.lastname: Rozman
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood*; D050171:Dyslipidemias / Q000209:etiology*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000145:classification / Q000150:complications / Q000188:drug therapy; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged
chemical_list: D002784:Cholesterol