[HDL2b lipoproteins as an acceptor of cholesterol from erythrocyte membrane and the role of lecithin-cholesterol-acyltransferase during this process].
The role of lecithin-cholesterol-acyltransferase (LCAT) in net cholesterol transport from erythrocyte membranes to one of high density lipoprotein subclasses--HDL2b--was studied in vitro. It was shown that an addition of partially purified LCAT to the incubation medium containing human HDL2b and human erythrocytes triggers free cholesterol transport from erythrocyte membranes to HDL2b. In this case, the rise in HDL cholesterol occurs mainly due to the formation of cholesteryl esters produced by LCAT. The significance of cholesterol ecceptor properties of HDL2b in vivo is discussed.
Nikiforova
A A
AA
Kheĭfets
G M
GM
Alksnis
E G
EG
Parfenova
N S
NS
Klimov
A N
AN
D001692:Biological Transport; D002784:Cholesterol / Q000097:blood*; D002788:Cholesterol Esters / Q000097:blood; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D053439:Lipoproteins, HDL2; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000378:metabolism*
D002788:Cholesterol Esters; D008075:Lipoproteins, HDL; D053439:Lipoproteins, HDL2; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase
Aktseptsiia kholesterina iz membran éritrotsitov podfraktsieĭ LPVP2b i rol' letsitin-kholesterin-atsiltransferazy v étom protsesse.