Radioimaging of lymph node involvement in prostatic carcinoma.
We have previously shown that Tc-99m- or In-111-labelled derivatives of monoclonal antibodies against prostatic acid phosphatase can be used to reveal bone metastases of prostatic carcinoma. In this study, seven patients who were candidates for radical prostatectomy and two patients with bone metastases, were investigated to evaluate the applicability of this technique for preoperative staging of the patients. One milligram of monoclonal antibodies was injected bilaterally into the periprostatic space, and the patients were subjected to measurements by gamma camera. In one patient metastases were detected in the left para-aortic, iliac and obturator lymph nodes by this technique. The lesions incorporating radioactivity were confirmed to be metastases of prostatic cancer following staging pelvic lymphadenectomy. In the other four patients, radioimaging did not show any lymph node metastases, and this negative finding was confirmed at the operation. These early data indicate the possibility of preoperative staging of prostatic cancer by means of radiolabelled derivates of monoclonal antibodies, raised against prostatic acid phosphatase and injected into the periprostatic area.
Kontturi
M
M
Department of Surgery, University of Oulu, Finland.
Lukkarinen
O
O
Vihko
P
P
Vihko
R
R
D000911:Antibodies, Monoclonal; D006801:Humans; D007205:Indium Radioisotopes; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008207:Lymphatic Metastasis; D008297:Male; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013667:Technetium
D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes; D013667:Technetium