[Effect of the induction of liver cytochrome P-450 by a chemically inert fluorocarbon on the reactions of immediate and delayed hypersensitivity].
The effect of chemically inert perfluorodecalin (PFD) on the development of hypersensitive reactions of immediate and delayed types in guinea pigs and mice was studied. It was found that administration of PFD to animals both before sensitization (mice) and during the development of sensitization (guinea pigs) reduced the degree of the both types of hypersensitivity.
Khlopushina
T G
TG
Krinskaia
A V
AV
Marokko
I N
IN
Kovalev
I E
IE
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005466:Fluorocarbons / Q000494:pharmacology*; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000209:etiology* / Q000276:immunology; D006969:Hypersensitivity, Immediate / Q000209:etiology* / Q000276:immunology; D007114:Immunization; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA
D005466:Fluorocarbons; C008805:perfluorodecalin; D003577:Cytochrome P-450 Enzyme System
Vliianie induktsii tsitokhroma P-450 pecheni khimicheski inertnym ftoruglerodom na reaktsii giverchuvstvitel'nosti nemedlennogo i zamedlennogo tipov.