Effect of long-term use of reserpine, a sympathetic neuron blocker, on muscarinic cholinergic receptors in the guinea pig nasal mucosa.
To evaluate whether hypofunction of the sympathetic nervous system induced by long-term reserpine treatment affects the parasympathetic system in the nasal mucosa in the receptor level, a receptor binding assay was performed using the nasal mucosa of guinea pigs which had chemical denervation produced by intraperitoneal injection of 0.1 mg/body reserpine once daily for 4 weeks. The maximum number of muscarinic cholinergic receptor bindings to diquinuclidinyl benzilate (3H-QNB) in the nasal mucosa of the reserpine-treated guinea pigs was increased by 46% as compared with that in the control (p less than 0.05). The present experiment shows that hypofunction of the sympathetic system in the nasal mucosa induced by reserpine may affect the parasympathetic system in the nasal mucosa.
Konno
A
A
Department of Otolaryngology, Akita University School of Medicine, Japan.
Terada
N
N
Okamoto
Y
Y
D000818:Animals; D006168:Guinea Pigs; D008297:Male; D009297:Nasal Mucosa / Q000294:innervation*; D011976:Receptors, Muscarinic / Q000187:drug effects*; D012110:Reserpine / Q000494:pharmacology*; D013563:Sympathectomy, Chemical; D013997:Time Factors
D011976:Receptors, Muscarinic; D012110:Reserpine