The effect of topical cyclosporin A on the elicitation phase of allergic contact dermatitis.
The effect of cyclosporin A (CSA) on the elicitation phase of allergic contact dermatitis was investigated. Initially, the ability of CSA to penetrate normal human cadaver skin was determined using 3 different vehicles. 10% CSA in Labrafil was found to be the most effective combination at achieving skin penetration (0.33%). Patients with known contact sensitivities to a variety of allergens were selected. After a 48-h pretreatment with 10% CSA in Labrafil, skin sites were exposed to the appropriate contact allergen. 72 h later, the development of an eczematous patch test reaction was evaluated. Only 1 of 10 patients showed unequivocal signs of suppression of allergic contact dermatitis.
Cole
G W
GW
Department of Dermatology, University of California, Irvine.
Shimomaye
S
S
Goodman
M
M
D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003524:Cyclosporins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003877:Dermatitis, Contact / Q000517:prevention & control*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D011897:Random Allocation; D012869:Skin Absorption
D003524:Cyclosporins