Pathology of hepatic peroxisomes in chronic hepatitis B and immunosuppression.
After kidney transplantation and immunosuppressive therapy patients with chronic hepatitis B show not only peroxisome proliferation in hepatocytes but also additional alterations of these organelles: lysis and occasional complete loss of peroxisomes in HBsAg areas as well as lysis and/or autophagocytic degradation of peroxisomes in hepatocytes which contained hepatitis-B virus particles. Two mechanisms are suggested as being significant for the numerical decrease of peroxisomes in HBsAg areas: Reduced neogenesis, but typical lytic degradation; Direct toxic action of immunosuppressive substances. For elucidation further studies have to be undertaken.
Reinke
P
P
Department of Ultrastructural Pathology and Electron Microscopy, Charité Hospital, Humboldt University, Berlin, G.D.R.
David
H
H
Uerlings
I
I
Decker
T
T
D001343:Autophagy; D002462:Cell Membrane / Q000473:pathology; D002908:Chronic Disease; D006509:Hepatitis B / Q000473:pathology*; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D007165:Immunosuppression Therapy; D008099:Liver / Q000648:ultrastructure*; D008830:Microbodies / Q000473:pathology*; D008854:Microscopy, Electron
D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens