The ultrastructural distribution of proteoglycans in normal and rachitic growth cartilage from the mandibular condyle of the rat.
The mandibular condylar cartilages from normal and rachitic weanling rats were stained with ruthenium red to demonstrate the distribution of proteoglycan. In the rachitic animal there was an increased concentration of ruthenium-red positive granules in the pericellular region of chondrocytes from the extended hypertrophic zone when compared with the controls. These aggregates may represent unmodified proteoglycan which excludes calcium and thereby prevents matrix calcification.
Appleton
J
J
Department of Dental Surgery, School of Dental Surgery, University of Liverpool, England, U.K.
D000818:Animals; D005260:Female; D006132:Growth Plate / Q000378:metabolism* / Q000648:ultrastructure; D006651:Histocytochemistry; D008297:Male; D008335:Mandibular Condyle / Q000378:metabolism* / Q000648:ultrastructure; D008854:Microscopy, Electron; D011509:Proteoglycans / Q000032:analysis*; D051381:Rats; D012279:Rickets / Q000378:metabolism* / Q000473:pathology
D011509:Proteoglycans