title: Serologic HLA typing in infantile spasms.
abstract: Serologic HLA typing was performed on 29 patients with infantile spasms and hypsarrhythmic patterns in their electroencephalograms (EEGs). There were no significant increases in the frequencies of HLA-A, B, and C antigens in the infantile spasm group as compared with controls. However, there was a significant increase in the frequency of DRw52 in the infantile spasm patients (90%) as compared with controls (72%) (p less than 0.05). In addition, 3 of 12 white infantile spasm patients demonstrated the complete B18,DR3 (DRw52) haplotype; none of 150 control white subjects showed this haplotype. These findings contribute to evidence that immunological mechanisms may be involved in the pathophysiology of infantile spasms.
authors.affiliation: Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.
authors.forename: R A
authors.initials: RA
authors.lastname: Hrachovy
authors.forename: J D
authors.initials: JD
authors.lastname: Frost
authors.forename: M S
authors.initials: MS
authors.lastname: Pollack
authors.forename: D G
authors.initials: DG
authors.lastname: Glaze
mesh_terms: D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D013036:Spasms, Infantile / Q000235:genetics*
chemical_list: D006680:HLA Antigens