[Association between synaptonemal complexes of sex and autosomal bivalents in male tx/ty mice as a possible cause of their sterility].
Electron microscopic study of total preparations of synaptonemal complexes of spermatocytes I from sterile heterozygous male mice--t12/tw18; tw5/twPa-1; twPa-1/tw18 was performed. T/tw18 and C3H/N fertile heterozygotes were used in each variant as control. The cells are karyotyped in all experiments, as based on the measurements of the length of 19 SC autosomes and SC sex complex. All sterile compounds (spermatocytes) demonstrate high frequency of different types of associations (72%) between sex chromosomes and the autosome 17 carrying a chromosomal aberration in the region of the T-locus. The heterozygotes tx/ty used in our experiments show no disruption of chromosome synapsis, when even studied under electron microscope, though some atypical changes in the ultrastructure of chromosome axes and frequent atypical associations of the axes of XY-sex bivalents in sterile heterozygous animals exist.
Safronova
L D
LD
Kolomiets
O L
OL
Bogdanov
Iu F
IuF
Safronov
V A
VA
Mazurova
T F
TF
D000483:Alleles; D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000648:ultrastructure*; D006579:Heterozygote; D007248:Infertility, Male / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D007621:Karyotyping; D008297:Male; D008540:Meiosis; D051379:Mice; D008854:Microscopy, Electron; D009154:Mutation; D013090:Spermatocytes / Q000648:ultrastructure; D013573:Synaptonemal Complex
Assotsiatsiia mezhdu sinaptonemnymi kompleksami polovykh i autosomnykh bivalentov u samtsov mysheĭ tx/ty kak vozmozhnaia prichina ikh steril'nosti.