Fluoro-Gold reveals patches of striatal neurons during development.
Patches of densely-labelled striatal neurons were observed following intrastriatal injection of the fluorescent dye Fluoro-Gold into rats younger than 10 days of age. These cell clusters showed precise overlap with islands of dense dopamine innervation seen only during the first week of life. The patches of labelled cells were still visible in adulthood, and were not abolished by 6-hydroxydopamine treatment before or after the Fluoro-Gold injection. Neonatal Fluoro-Gold injection may be a unique way of marking the patch compartment of the striatum that remains visible in adulthood.
Snyder-Keller
A M
AM
Department of Neurobiology, Anatomy and Cell Science, University of Pittsburgh School of Medicine, PA 15261.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002455:Cell Division; D003342:Corpus Striatum / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005456:Fluorescent Dyes / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013266:Stilbamidines; D013936:Thymidine
C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D005456:Fluorescent Dyes; D013266:Stilbamidines; D013936:Thymidine; D004298:Dopamine