[Effect of amino acid derivatives of beta-carboline on the evoked activity of hippocampal neurons].
The action of methylamide-beta-carboline-3-carboxylate (1), glycinamide-beta-carboline-3-carboxylate methyl ester (2), leucinamide-beta-carboline-3-carboxylate methyl ester (3) on evoked activity of hippocampal neurons was investigated using brain slice technique. Both 1 and 2 application (5 mkM, 15 min) reduced paired-pulse inhibition (PPI). Single-pulse and frequency stimulation revealed population spike (PS) increase or generation of additional PS after 1 or 2 application, the former drug being more active at all stimulation patterns. 3 had no definitive activity in the test-system used. The data obtained suggest similarity of pharmacological profiles of 1 and 2, and anxiogenic activity of 2 in vivo.
Glushankov
P G
PG
Pliashkevich
Iu G
IuG
D000818:Animals; D001007:Anxiety / Q000139:chemically induced; D002243:Carbolines / Q000494:pharmacology*; D046508:Culture Techniques; D004558:Electric Stimulation / Q000379:methods; D005071:Evoked Potentials / Q000187:drug effects; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D002243:Carbolines; C057992:glycinamide-beta-carboline-3-carboxylate methyl ester; C057993:leucinamide-beta-carboline-3-carboxylate methyl ester; C035874:FG 7142; D007930:Leucine; D005998:Glycine
Vliianie aminokislotnykh proizvodnykh beta-karbolina na vyzvannuiu aktivnost' neĭronov gippokampa.