title: Replicative behaviour of ascites tumour cells transplanted in BALB C mice of different sex.
abstract: The present research demonstrates that cells from an ascites tumour (ATP C+) multiply more actively in the peritoneum of male mice, provided they are maintained alive in this environment for long periods of time by weekly transplants in animals of the same sex. Solid tumours obtained by inoculating ATP C+ cells, removed from the peritoneum of male mice, into the subcutaneous dorsal region of castrated male mice, grew more rapidly than those obtained by inoculating the same cells removed from the peritoneum of female mice, always provided that the cells had been passaged at length in animals of the same sex. Cytogenetical studies of these two cell subpopulations revealed that cells reproduced for 2 years in males had a less stabile karyotype and a greater incidence of acrocentric associations.
authors.affiliation: Institute of General Biology, University of Perugia, Italy.
authors.forename: F S
authors.initials: FS
authors.lastname: Liotti
authors.forename: A R
authors.initials: AR
authors.lastname: Menghini
authors.forename: P
authors.initials: P
authors.lastname: Guerrieri
authors.forename: R
authors.initials: R
authors.lastname: Armellini
mesh_terms: D000818:Animals; D002369:Castration; D002455:Cell Division; D002460:Cell Line; D005260:Female; D007621:Karyotyping; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D010537:Peritoneum / Q000473:pathology; D012727:Sex Characteristics