Early neutrophil alveolitis after rechallenge in drug induced alveolitis.
A patient with drug induced alveolitis due to an antidepressant drug, nomifensine, is described. After an inadvertent rechallenge by the patient sequential bronchoalveolar lavage was carried out. Twenty four hours after the rechallenge the lavage fluid contained a high cell count with neutrophils predominating. Seven days after challenge the cells were predominantly lymphocytes.
Salmeron
S
S
Service de Pneumologie et Réanimation, Hôpital Antoine Béclère, Clamart, France.
Brochard
L
L
Rain
B
B
Herve
P
P
Brenot
F
F
Simonneau
G
G
Duroux
P
P
D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced / Q000473:pathology*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology*; D009627:Nomifensine / Q000009:adverse effects*
D009627:Nomifensine