title: Therapeutic effectiveness of iodine-131 MIBG metastases of a nonsecreting paraganglioma.
abstract: This case report describes the treatment of the bone metastases of a nonfunctioning sympathetic paraganglioma, with [131I]MIBG. After primary tumor excision and unsuccessful external radiotherapy, the patient received three therapeutic doses of [131I]MIBG, resulting in a reduction of the number and volume of metastases, and an improvement of the general condition. At 3 yr following [131I]MIBG therapy, the patient remained in remission. [131I]MIBG appears to be an efficient and safe agent for treating malignant sympathetic paraganglioma.
authors.affiliation: Unité INSERM U316, Département de Cancérologie, Tours, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Baulieu
authors.forename: D
authors.initials: D
authors.lastname: Guilloteau
authors.forename: F
authors.initials: F
authors.lastname: Baulieu
authors.forename: O
authors.initials: O
authors.lastname: Le Floch
authors.forename: C
authors.initials: C
authors.lastname: Chambon
authors.forename: L
authors.initials: L
authors.lastname: Pourcelot
authors.forename: J C
authors.initials: JC
authors.lastname: Besnard
mesh_terms: D019797:3-Iodobenzylguanidine; D000328:Adult; D001859:Bone Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007462:Iodobenzenes / Q000627:therapeutic use*; D010235:Paraganglioma / Q000532:radiotherapy*; D012186:Retroperitoneal Neoplasms / Q000532:radiotherapy*
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine