title: GM1 ganglioside protects nucleus basalis from excitotoxin damage: reduced cortical cholinergic losses and animal mortality.
abstract: Ten days after bilateral injections of ibotenic acid into the nucleus basalis, rats injected daily (i.m.) with ganglioside GM1 were protected from anterograde degeneration of cholinergic projections to the fronto-lateral cortex. This protection was reflected by reduced losses (associated with ibotenic acid lesions) of cortical acetylcholinesterase, choline acetyltransferase, and lowered animal mortality.
authors.affiliation: Division of Neuroscience, New York State Psychiatric Institute, New York 10032.
authors.forename: S P
authors.initials: SP
authors.lastname: Mahadik
authors.forename: F
authors.initials: F
authors.lastname: Vilim
authors.forename: A
authors.initials: A
authors.lastname: Korenovsky
authors.forename: S E
authors.initials: SE
authors.lastname: Karpiak
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001479:Basal Ganglia / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D002540:Cerebral Cortex / Q000166:cytology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002799:Cholinergic Fibers / Q000187:drug effects / Q000378:metabolism*; D005677:G(M1) Ganglioside / Q000008:administration & dosage*; D007051:Ibotenic Acid / Q000633:toxicity*; D007273:Injections, Intramuscular; D008297:Male; D010080:Oxazoles / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010080:Oxazoles; D007051:Ibotenic Acid; D005677:G(M1) Ganglioside; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase