Skeletal muscle ventricles as a potential right heart assist or substitute.
Skeletal muscle ventricles (SMV) were constructed from canine latissimus dorsi muscle and chronically stimulated to pump fluid within a totally implantable mock circulation device. They were stimulated to contract at either 95/min (N = 7) or 54/min (N = 4). The preload was chronically maintained at 20 mmHg. After 1 month of continuous pumping the SMV were capable of generating a stroke work of 0.134 X 10(6) ergs and power output of 0.021 watts, representing 61% and 42% of the stroke work and power output of the native canine right ventricle, respectively.
Anderson
W A
WA
Harrison Department of Surgical Research, Philadelphia, Pennsylvania.
Andersen
J S
JS
Bridges
C R
CR
Hammond
R L
RL
DiMeo
F
F
Frisch
E E
EE
Salmons
S
S
Stephenson
L W
LW
D000818:Animals; D001243:Assisted Circulation; D002302:Cardiac Output; D003326:Coronary Circulation; D004285:Dogs; D004868:Equipment Failure; D006353:Heart-Assist Devices; D009132:Muscles / Q000637:transplantation*; D011183:Postoperative Complications / Q000209:etiology; D013318:Stroke Volume