Corticosteroid effects on cholinergic enzymes in ethanol-treated fetal brain cell cultures.
In the presence of ethanol, corticosterone and dexamethasone inhibit choline acetyltransferase and acetyl-cholinesterase activities in cultured fetal brain cells of the rat. These results suggest that corticosteroids may have an important influence on the activity of cholinergic enzymes in the fetal brain may antagonize the effects of ethanol in this setting.
Brown
J W
JW
Medical Research Service, Veterans Administration Medical Center, Miami, Florida.
Okonmah
A D
AD
Soliman
K F
KF
Carballeira
A
A
Fishman
L M
LM
D000110:Acetylcholinesterase / Q000378:metabolism*; D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000196:embryology* / Q000201:enzymology; D002478:Cells, Cultured; D002795:Choline O-Acetyltransferase / Q000037:antagonists & inhibitors*; D002800:Cholinesterase Inhibitors; D003345:Corticosterone / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000305:Adrenal Cortex Hormones; D002800:Cholinesterase Inhibitors; D000431:Ethanol; D003907:Dexamethasone; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase; D003345:Corticosterone