High hepatic excretion in humans of cefpiramide, a new cephalosporin.
After intravenous administration of 1 g of cefpiramide, the biliary elimination of the drug was studied by using high-performance liquid chromatography. In five healthy volunteers, a mean peak concentration of 339 +/- 107 (standard error of the mean) micrograms/ml was measured in aspirated duodenal fluid during h 2 after administration, and 1.2% of the dose given was recovered over a 4-h period. A maximal concentration of 1,161 +/- 392 micrograms/ml was reached during h 2 in T-tube bile from 10 recently cholecystectomized patients, with a 24-h biliary recovery of 23.1%; urinary recovery over the same period averaged 49.4%. In 10 patients undergoing cholecystectomy, the concentrations in serum, choledochal bile, gallbladder bile, and gallbladder wall 1 h after cefpiramide administration were 157 +/- 21, 1,726 +/- 501, and 84 +/- 33 micrograms/ml and 23 +/- 4 micrograms/g, respectively. These figures represent the highest biliary concentrations attained so far with a beta-lactam antibiotic and are therefore a good prerequisite for treatment of biliary tract infections with cefpiramide.
Brogard
J M
JM
Department of Internal Medicine, Hospital-University Center of Strasbourg, France.
Jehl
F
F
Adloff
M
M
Blickle
J F
JF
Monteil
H
H
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics; D001646:Bile / Q000378:metabolism*; D002511:Cephalosporins / Q000493:pharmacokinetics*; D002763:Cholecystectomy; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008099:Liver / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C036666:cefpiramide