title: HLA-A,B,C, and DR antigens, GLO I and Bf marker profiles in 75 Cape coloured patients with systemic lupus erythematosus (SLE).
abstract: HLA-A,B,C and DR antigens were tested in 75 Cape Coloured systemic lupus erythematosus (SLE) patients, and the GLO I and Bf markers in 51. The patients with HLA-DR2 had a relative risk significantly greater than one (p=0.0005). Twenty-two (29%) patients had only one detectable DR antigen. Of these, 11 (50%) were found to have DR2 only. The HLA-DR7 antigen was associated with severe disease (p less than 0.02). Bf and GLO I markers were not associated with SLE.
authors.affiliation: Department of Medicine, University of Cape Town Medical School, South Africa.
authors.forename: P
authors.initials: P
authors.lastname: Klemp
authors.forename: E D
authors.initials: ED
authors.lastname: du Toit
authors.forename: S
authors.initials: S
authors.lastname: Issacs
authors.forename: G M
authors.initials: GM
authors.lastname: Mody
authors.forename: M
authors.initials: M
authors.lastname: Oudshoorn
mesh_terms: D011415:Complement Factor B / Q000032:analysis / Q000235:genetics*; D004792:Enzyme Precursors / Q000235:genetics*; D005819:Genetic Markers; D015234:HLA-A Antigens / Q000235:genetics* / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D015236:HLA-C Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000032:analysis / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D008190:Lyases / Q000235:genetics*; D012306:Risk; D012880:Skin Pigmentation; D013019:South Africa; D013223:Statistics as Topic
chemical_list: D004792:Enzyme Precursors; D005819:Genetic Markers; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens; D011415:Complement Factor B; D008190:Lyases; D007791:Lactoylglutathione Lyase