[Dalargin--an opioid-like peptide with peripheral action].
Hexapeptide dalargin (Tyr-Dala-Gly-Phe-Leu-Arg) and its N-terminal penta- and tetrapeptide fragments significantly differed by the peripheral opioid activity "spectra" on three models of isolated organs: the guinea pig ileum, the mouse vas deferens and the mouse large intestine. N-terminal tripeptide and tyrosine-free fragment of Dala-Gly-Phe-Leu possessed no opioid properties. Dalargin and its opioid-like fragments exerted the analgesic effect according to the hot plate and tail flick tests in mice. When administered intracisternally they were inferior in the activity to a stable analogue of enkephalins FK 33-824 by 1-3 orders, at intravenous administration by tens of times. The data obtained suggest that dalargin is an opioid-like peptide with the peripheral action.
Korobov
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D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D005071:Evoked Potentials / Q000187:drug effects; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010146:Pain / Q000188:drug therapy; D010446:Peptide Fragments / Q000494:pharmacology / Q000627:therapeutic use
D000700:Analgesics; D010446:Peptide Fragments; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Dalargin--opiopodobnyĭ peptid perifericheskogo deĭstviia.