Pedigree analysis of HDL cholesterol concentration in baboons on two diets.
Using complex segregation analysis, we examined the effects of genetic factors and diet on serum concentrations of high-density-lipoprotein cholesterol (HDL-C) in baboons. In analyses of 710 baboons in 23 sire families, we found evidence for a major gene as well as a polygenic contribution to HDL-C concentration in baboons fed a basal (chow) diet and also in the same animals after challenge with a high-cholesterol, saturated-fat diet. There was evidence for a polygenic contribution to the change in HDL-C concentration in response to the dietary challenge, but there was no evidence for a major gene effect.
MacCluer
J W
JW
Southwest Foundation for Biomedical Research, San Antonio, TX 78284.
Kammerer
C M
CM
Blangero
J
J
Dyke
B
B
Mott
G E
GE
VandeBerg
J L
JL
McGill
H C
HC
D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics*; D004036:Diet, Atherogenic; D005260:Female; D014644:Genetic Variation; D008297:Male; D008957:Models, Genetic; D010215:Papio / Q000097:blood / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype
D008076:Cholesterol, HDL