[The stability of norepinephrine hydrogen tartrate, epinephrine hydrogen tartrate and isoprenaline sulfate. 29. The stability of drugs and preparations].
Stability testing of derivatives of brenzcatechine [norepinephrine hydrogentartrate (1), epinephrine hydrogentartrate (2), isoprenaline sulfate (3)] was carried out by stress investigation storing them at different temperatures. Substances of different charges which had been stored under normal conditions were analyzed. After a period of induction all three substances had been decomposed with a higher velocity. The order of kinetic process could not be determined. The storage life time was calculated by the aid of nonlinear regression. Time limit for storage of 5 years for 1 and 2 were confirmed. We suggest to extend it for 3 to 10 years.
Müller
C
C
Sektion Pharmazie der Ernst-Moritz-Arndt-Universität Greifswald.
Burghardt
G
G
Wollmann
H
H
D004355:Drug Stability; D004837:Epinephrine / Q000032:analysis*; D007545:Isoproterenol / Q000032:analysis*; D007700:Kinetics; D009638:Norepinephrine / Q000032:analysis*
D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine
Untersuchungen zur Stabilität von Norepinephrinehydrogentartrat, Epinephrinhydrogentartrat und Isoprenalinsulfat. 29. Mitteilung: Sabilität von Arzneistoffen und Zubereitungen.