title: Shape of forced expiratory flow-volume curves in infants.
abstract: An inflatable cuff was used to generate partial forced expiratory flow-volume (FEFV) curves in 36 infants with and without obstructive airway disease. Curves were recorded in each infant over a range of compression pressures as high as and exceeding the pressure required for the maximal partial FEFV curve. The maximal curves were quantitated and compared with passive compliance and conductance of the respiratory system and absolute lung volume measured by whole-body plethysmography. In some infants, the transmission of pressure between cuff and pleural space was determined. Partial FEFV curve shapes generated with a standardized compression pressure calculated from the transmission of pressure data to give an increase in pleural pressure at FRC of 10 cm H2O were compared between infants. For these standardized compressions, infants with convex curves tended to have better respiratory function than did those with concave curves. The combination of a concave curve and flow limitation during tidal expiration was associated with the worst function. Two parameters, the ratio of forced maximal expiratory flow (measured from the maximal partial FEFV curve) to tidal expiratory flow (measured from the expiratory flow-volume curve of tidal breathing) at midtidal volume (Vm1d(forced/tidal] and the minimal compression pressure required to generate maximal expiratory flow at FRC (Pmin), satisfactorily quantified respiratory function without the need for size correction with absolute lung volume. In addition, Vm1d(forced/tidal) provides an index of expiratory flow reserve. We conclude that useful information can be provided from the shape of a partial FEFV curve in an infant, provided that curves are generated by a standardized compression pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Professorial Department of Thoracic Medicine, Royal Childrens Hospital, Parkville, Victoria, Australia.
authors.forename: P N
authors.initials: PN
authors.lastname: Le Souëf
authors.forename: D M
authors.initials: DM
authors.lastname: Hughes
authors.forename: L I
authors.initials: LI
authors.lastname: Landau
mesh_terms: D001988:Bronchiolitis / Q000503:physiopathology; D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology; D003550:Cystic Fibrosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000502:physiology*; D008297:Male; D008449:Maximal Expiratory Flow-Volume Curves; D012129:Respiratory Function Tests / Q000295:instrumentation / Q000379:methods