title: Proton microprobe and particle induced X-ray emission (PIXE) analysis for studies of pathological brain tissue.
abstract: Particle Induced X-ray Emission and proton microprobe analyses have been applied for the investigation of regional elemental distributions in connection with various pathological states in the brain. Malignant brain tumours and adjacent histologically intact tissue removed during surgery were analysed with PIXE. Systematic elemental variations, e.g., for calcium and selenium, were observed in the tumour front. The proton microprobe was applied to study the Ca and K concentrations in various cell strata in hippocampus following transient ischaemia in rat brain. Significant increases in the Ca level occurred in selectively vulnerable cells within 48 h after the ischaemia.
authors.affiliation: Dept. Nuclear Physics, Lund Inst. Sci. & Technol., Sweden.
authors.forename: K G
authors.initials: KG
authors.lastname: Malmqvist
authors.forename: A
authors.initials: A
authors.lastname: Brun
authors.forename: K
authors.initials: K
authors.lastname: Inamura
authors.forename: E
authors.initials: E
authors.lastname: Martins
authors.forename: L G
authors.initials: LG
authors.lastname: Salford
authors.forename: B K
authors.initials: BK
authors.lastname: Siesjö
authors.forename: U A
authors.initials: UA
authors.lastname: Tapper
authors.forename: K
authors.initials: K
authors.lastname: Themner
mesh_terms: D000818:Animals; D001254:Astrocytoma / Q000032:analysis / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001923:Brain Chemistry; D002545:Brain Ischemia / Q000473:pathology*; D001932:Brain Neoplasms / Q000032:analysis / Q000473:pathology*; D002118:Calcium / Q000032:analysis; D004577:Electron Probe Microanalysis; D006801:Humans; D008297:Male; D011188:Potassium / Q000032:analysis; D051381:Rats
chemical_list: D011188:Potassium; D002118:Calcium