Acute effects of human growth hormone on zinc, copper, calcium and magnesium metabolism in normal subjects.
The acute effects of human growth hormone (hGH) on the metabolism of zinc, copper, calcium and magnesium ions was studied. Seven normal subjects were perfused iv with doses of 0.2 or 1.0 mg hGH over a period of 60 min. An increase in plasma zinc, calcium and magnesium, and a decrease in plasma copper levels was noted for the 0.2 mg dose, and these effects were reversed for the 1.0 mg dose although no urine changes occurred. Plasma mobilization of these ions appears to be related to their roles as essential physiological modulators for the action of hGH.
Brandão-Neto
J
J
Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, Brasil.
Kimachi
T
T
Veríssimo
J M
JM
Shuhama
T
T
Marchini
J S
JS
Antunes-Rodrigues
J
J
D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D003300:Copper / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005260:Female; D013006:Growth Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007262:Infusions, Intravenous; D008274:Magnesium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D015032:Zinc / Q000097:blood / Q000378:metabolism* / Q000652:urine
D003300:Copper; D013006:Growth Hormone; D008274:Magnesium; D015032:Zinc; D002118:Calcium