Age-related changes of muscimol binding in the substantia nigra.
Receptor binding studies of the substantia nigra (SN) and cerebellum revealed two affinity sites for muscimol binding in the SN and cerebellum of adult and 16-day-old rats. Scatchard analysis revealed a paucity of high-affinity muscimol receptors in the SN of 16-day-old rat pups. These results suggest that the lack of anticonvulsant action of muscimol in the SN of 16-day-old rat pups may be due to the paucity of high-affinity muscimol receptors as compared to adult rats.
Wurpel
J N
JN
Department of Neurology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461.
Tempel
A
A
Sperber
E F
EF
Moshé
S L
SL
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002531:Cerebellum / Q000254:growth & development / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009118:Muscimol / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000254:growth & development / Q000378:metabolism*
D009118:Muscimol