title: The incidence of hybrid acute leukaemias.
abstract: During a 4-yr period, 292 patients with acute leukaemia were studied using morphology, cytochemistry and immunologic reagents to determine the cell lineage of the leukaemia. One hundred and sixty-three cases were shown to be acute lymphoblastic leukaemia (ALL), 127 acute myeloblastic leukaemia (AML) and two cases (0.6%) were classified as hybrid acute leukaemias. One was biphenotypic in which the blast cells displayed both T-lymphoid (60% E-rosettes) and megakaryocytic markers (47% CDw41/glycoprotein IIb/IIIa antigen, 50% myeloperoxidase). The second was a bilineal acute leukaemia in which some blast cells displayed B-lymphoid (47% CD10/CALLA, 40% acid phosphatase) features and other megakaryocytic (33% coagulation factor VIII:WVf antigen)/myeloid (30% Sudan Black) features. This study suggests that hybrid acute leukaemia are rare.
authors.affiliation: Laboratorios Clínicos de Puebla, Centro de Hematología y Medicina Interna de Puebla, México.
authors.forename: G J
authors.initials: GJ
authors.lastname: Ruiz-Argüelles
authors.forename: E
authors.initials: E
authors.lastname: Lobato-Mendizábal
authors.forename: A
authors.initials: A
authors.lastname: Marín-López
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D008800:Mexico; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal