Therapeutic effectiveness of iodine-131 MIBG metastases of a nonsecreting paraganglioma.
This case report describes the treatment of the bone metastases of a nonfunctioning sympathetic paraganglioma, with [131I]MIBG. After primary tumor excision and unsuccessful external radiotherapy, the patient received three therapeutic doses of [131I]MIBG, resulting in a reduction of the number and volume of metastases, and an improvement of the general condition. At 3 yr following [131I]MIBG therapy, the patient remained in remission. [131I]MIBG appears to be an efficient and safe agent for treating malignant sympathetic paraganglioma.
Baulieu
J L
JL
Unité INSERM U316, Département de Cancérologie, Tours, France.
Guilloteau
D
D
Baulieu
F
F
Le Floch
O
O
Chambon
C
C
Pourcelot
L
L
Besnard
J C
JC
D019797:3-Iodobenzylguanidine; D000328:Adult; D001859:Bone Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007462:Iodobenzenes / Q000627:therapeutic use*; D010235:Paraganglioma / Q000532:radiotherapy*; D012186:Retroperitoneal Neoplasms / Q000532:radiotherapy*
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine