title: [The effect of calcium pantothenate and homopantothenate on [14C]-GABA absorption by slices of rat cerebral cortex].
abstract: Calcium D-pantothenate (Ca D-P) and calcium D-homopantothenate (Ca D-HP) (pantogam) exhibiting antagonism in a number tests of pharmacological screening were shown to inhibit the absorption of [14C]-GABA (0.2 microM) by the rat brain cortex slices (3 mm) incubated in calcium-free medium. The effect of Ca D-HP manifests at its low concentrations (10(-6) M) and that of Ca D-P at high concentrations (10(-6) M). The data obtained are discussed in relation to the possible influence of the anion and cation components of the studied compounds.
authors.forename: T E
authors.initials: TE
authors.lastname: Reĭtarova
authors.forename: V A
authors.initials: VA
authors.lastname: Rozanov
authors.forename: M A
authors.initials: MA
authors.lastname: Kovler
authors.forename: V M
authors.initials: VM
authors.lastname: Kopelevich
authors.forename: V N
authors.initials: VN
authors.lastname: Totskiĭ
mesh_terms: D000042:Absorption; D000818:Animals; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D018756:GABA Antagonists; D008297:Male; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D002250:Carbon Radioisotopes; D018756:GABA Antagonists; C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid
vernacular_title: Vliianie pantotenata i gomopantotenata kal'tsiia na pogloshchenie [14C]-GAMK srezami kory golovnogo mozga krys.