title: Viral myb oncogene encodes a sequence-specific DNA-binding activity.
abstract: The retroviral oncogene v-myb and its cellular progenitor c-myb encode nuclear DNA-binding proteins. Myb genes have been identified in a broad range of species, including vertebrates, the fruit fly Drosophila melanogaster and the plant Zea mays. The localization of the DNA-binding domain of the v-MYB protein to the highly conserved amino-terminal region suggests that the MYB/DNA interaction is important for MYB function. We show here that v-MYB specifically recognizes the nucleotide sequence pyAACG/TG. So like other nuclear transforming proteins, v-MYB seems to be a member of the class of sequence-specific DNA-binding factors presumably involved in gene regulation.
authors.affiliation: Zentrum für Molekulare Biologie der Universität Heidelberg, FRG.
authors.forename: H
authors.initials: H
authors.lastname: Biedenkapp
authors.forename: U
authors.initials: U
authors.lastname: Borgmeyer
authors.forename: A E
authors.initials: AE
authors.lastname: Sippel
authors.forename: K H
authors.initials: KH
authors.lastname: Klempnauer
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D003001:Cloning, Molecular; D004247:DNA / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D020626:Oncogene Proteins v-myb; D009857:Oncogenes; D010957:Plasmids; D012191:Retroviridae Proteins / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D020626:Oncogene Proteins v-myb; D012191:Retroviridae Proteins; D004247:DNA