Chemically induced inflammation in rat oral mucosa.
The toxic, irritative, and sensitizing effects of topically applied sodium lauryl sulfate (SLS), dithranol triacetate (DTA), nonanoic acid in methyl- or propyl ester (NAM, NAP) in the buccal mucosa were investigated in a Sprague-Dawley rat model. Semi-quantitative evaluations of cellular infiltrates were performed in routine histologic preparations. The toxic potential was tested with 2% and 0.2% solutions. All substances, except 0.2% SLS, caused an increased cellularity, mainly of a mononuclear cell type. The low dose of NAM induced stronger inflammatory reactions than the high dose. Repeated applications of 2% solutions decreased the response compared to one application, except for NAM, where a clear irritative potential was observed. Pre-exposure of dorsal skin prior to buccal painting resulted in an enhanced reaction to NAM and NAP, whereas no sensitizing capacity was noted in SLS or DTA in this model.
Ahlfors
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EE
Department of Oral Pathology, University of Lund, Malmö, Sweden.
Larsson
A
A
D000485:Allergens; D000818:Animals; D000875:Anthralin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000009:adverse effects*; D005227:Fatty Acids / Q000008:administration & dosage / Q000009:adverse effects*; D007509:Irritants; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage / Q000009:adverse effects*; D013280:Stomatitis / Q000139:chemically induced* / Q000473:pathology
D000485:Allergens; D000891:Anti-Infective Agents, Local; D005227:Fatty Acids; D007509:Irritants; D012967:Sodium Dodecyl Sulfate; C003629:triacetyldithranol; C008776:pelargonic acid; D000875:Anthralin