The effect of tumour-bearing on 2-deoxy[U-14C]glucose uptake in normal and neoplastic tissues in the rat.
The extent to which normal and neoplastic tissues of the rate take up glucose was assessed by the 2-deoxy[U-14C]glucose tracer technique. Measurements of glucose uptake were made over 40 min in anaesthetized rats under conditions where the blood glucose concentration was constant. In fed tumour-bearing rats, the relative rates of glucose uptake per g wet wt. of tissue were tumour (100), small intestine (72), brain (61), heart (61), spleen (50), lung (42), adipose tissue (11) and muscle (8). Normal tissues of the fed tumour-bearing rats had decreased rates of glucose uptake as compared with the same tissues in fed non-tumour-bearing control rats. Blood glucose concentrations were similar in both groups, but insulin concentrations were decreased in tumour-bearing rats. Starvation decreased the rates of glucose uptake by normal tissues in both control and tumour-bearing rats, but the difference between the fed and starved states was greater in the control rats. Starvation did not decrease glucose uptake by the tumour. On an organ basis, the tumour (12-14% of body wt.) took up 4 times more glucose than did muscle (40% of body wt.).
Rofe
A M
AM
Division of Clinical Chemistry, Institute of Medical and Veterinary Science, Adelaide, Australia.
Bourgeois
C S
CS
Bais
R
R
Conyers
R A
RA
D000230:Adenocarcinoma / Q000378:metabolism*; D000818:Animals; D003837:Deoxy Sugars / Q000493:pharmacokinetics*; D003847:Deoxyglucose / Q000493:pharmacokinetics*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D051381:Rats; D013217:Starvation / Q000378:metabolism; D014018:Tissue Distribution
D003837:Deoxy Sugars; D003847:Deoxyglucose