title: Characteristic variations of serum alkaline DNase activity in relation to response to therapy and tumor prognosis in human lung cancer.
abstract: The objective of the present study was to evaluate serum alkaline DNase activity (SADA) variations as a useful means of lung cancer monitoring therapy. SADA was measured in 40 patients with non-small cell and small cell carcinomas. Blood samples were collected before (Time 0), during the treatment and months after therapy. A decrease in SADA during the first treatment indicates a good clinical response, whereas an absence of decrease indicates a non-response to treatment. In patients who respond to therapy, three types of variations of SADA are observed during the clinical course. A progressive regaining of SADA up to a value largely exceeding the level of the initial SADA value (T0) correlates with a complete remission. An incomplete regaining of enzyme activity corresponds to a partial remission, whereas no regaining of SADA precedes a fatal evolution. Such variations in SADA observed in the 40 patients with lung carcinomas support our previously published clinical results, confirming that the variations of SADA could be a reliable marker for the therapeutic monitoring of different human malignancies.
authors.affiliation: Unité de Biochimie Toxicologique et Cancérologique, Faculté de Médecine, Université de Louvain, Bruxelles, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Economidou-Karaoglou
authors.forename: M
authors.initials: M
authors.lastname: Opsomer
authors.forename: G
authors.initials: G
authors.lastname: Petit
authors.forename: M
authors.initials: M
authors.lastname: Lans
authors.forename: H S
authors.initials: HS
authors.lastname: Taper
authors.forename: M B
authors.initials: MB
authors.lastname: Roberfroid
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D003851:Deoxyribonucleases / Q000097:blood*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D003851:Deoxyribonucleases