title: The effect of low dose rate on recovery of hemopoietic and stromal progenitor cells in gamma-irradiated mouse bone marrow.
abstract: Long-term recovery of mouse hemopoietic stem cells (CFU-S and CFU-S per colony), granulocyte-macrophage precursor cells (GM-CFC), and stromal colony-forming units (CFU-F) after doses up to 12.5 Gy was almost complete by 1 year when the dose rate was reduced to 0.0005 Gy/min compared to incomplete recovery after doses up to only 6.5 Gy given at greater than 0.7 Gy/min. This sparing effect of dose rate on long-term hemopoietic recovery is in contrast to the generally reported lack of dependence on dose rate for acute survival of hemopoietic progenitors after doses up to 5 Gy. The present results are compatible with the hypothesis that good recovery of the stroma should be reflected in the long-term recovery of hemopoiesis.
authors.affiliation: Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.
authors.forename: R
authors.initials: R
authors.lastname: Gallini
authors.forename: J H
authors.initials: JH
authors.lastname: Hendry
authors.forename: G
authors.initials: G
authors.lastname: Molineux
authors.forename: N G
authors.initials: NG
authors.lastname: Testa
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D002470:Cell Survival; D002588:Cesium Radioisotopes; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D006098:Granulocytes / Q000166:cytology / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000528:radiation effects*; D008264:Macrophages / Q000166:cytology / Q000528:radiation effects; D008297:Male; D051379:Mice
chemical_list: D002588:Cesium Radioisotopes; D003037:Cobalt Radioisotopes