Cyclo(His-Pro) and the development of tolerance to the hypothermic effect of ethanol.
Acute intraperitoneal administration of ethanol to rats causes a dose-dependent transient hypothermia. On repeated exposure, however, rats develop tolerance to hypothermic effects of ethanol. Cyclo(His-Pro), an endogenous brain peptide, modifies both acute and chronic themomodulatory effects of alcohol. For example, a) acute pretreatment of rats with increasing amounts of cyclo(His-Pro) produces a progressive decrease in ethanol hypothermia, and b) chronic cyclo(His-Pro) administration augments the development of tolerance to hypothermic effects of alcohol. While the mechanism of cyclo(His-Pro) action is not clear, these data are interpreted to suggest that this peptide may play important roles in ethanol intoxication, preference, tolerance, and/or addiction.
Prasad
C
C
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
Balasubramanian
P
P
D000079:Acetaldehyde / Q000633:toxicity; D000818:Animals; D004361:Drug Tolerance; D000431:Ethanol / Q000633:toxicity*; D007036:Hypothermia, Induced; D008297:Male; D010456:Peptides, Cyclic / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010456:Peptides, Cyclic; D010879:Piperazines; D000431:Ethanol; D000079:Acetaldehyde; C015924:histidyl-proline diketopiperazine