Carbamazepine-induced reduction of plasma alprazolam concentrations: a clinical case report.
A patient with atypical bipolar disorder and panic attacks treated with alprazolam 7.5 mg/day showed a greater than 50% reduction in plasma alprazolam concentrations after carbamazepine treatment was initiated and experienced a corresponding clinical deterioration. Clinical and plasma concentration data are presented.
Arana
G W
GW
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425.
Epstein
S
S
Molloy
M
M
Greenblatt
D J
DJ
D000328:Adult; D000525:Alprazolam / Q000097:blood* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy*; D002220:Carbamazepine / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male
D002220:Carbamazepine; D000525:Alprazolam