Neutrophil degranulation and increased pulmonary capillary permeability following oesophagectomy: a model of early lung injury in man.
In nine subjects undergoing oesophagectomy a transient but significant increase in pulmonary vascular permeability to transferrin was detected in both lungs 8 h after surgery. It coincided with a significant increase in plasma lactoferrin, evidence of intravascular and intra-alveolar neutrophil elastase release and with arterial hypoxaemia. The postoperative state in these patients had intravascular and pulmonary features often associated with the adult respiratory distress syndrome, and might be a useful model for the study of the early inflammatory events underlying lung injury in man.
Rocker
G M
GM
Respiratory Medicine Unit, City Hospital, Nottingham, UK.
Wiseman
M S
MS
Pearson
D
D
Shale
D J
DJ
D000368:Aged; D001772:Blood Cell Count; D002199:Capillary Permeability; D004947:Esophagus / Q000601:surgery*; D005260:Female; D006801:Humans; D008168:Lung / Q000098:blood supply; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D011183:Postoperative Complications / Q000503:physiopathology*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology*; D013908:Thoracotomy; D014168:Transferrin / Q000493:pharmacokinetics
D014168:Transferrin