Neoplasms in NIH type II athymic (nude) mice.
Necropsy and histopathology were performed over an 18-month period on 173 NIH type II athymic (nude) mice and 53 NIH type II mice heterozygous at the nu locus. A total of 149 mice were used in studies of tumor transplantation while 77 mice were screened as part of the quality assurance program for the colony. Twenty-nine neoplasms were found in 173 nu/nu mice. Only one neoplasm, an ovarian granulosa cell tumor, was found in 53 nu/+ mice. In nu/nu mice, there were nineteen lymphosarcomas, nine ovarian granulosa cell tumors, and one transitional cell carcinoma of the urinary bladder. A greater number of lymphosarcomas occurred in mice greater than 6 months old. A greater number of tumors, particularly lymphosarcomas, were found in nu/nu mice than in nu/+ mice.
Sadoff
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Division of Animal Medicine, School of Medicine, University of Washington, Seattle 98195.
Giddens
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DiGiacomo
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Vogel
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D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary; D005260:Female; D006106:Granulosa Cell Tumor / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary; D006579:Heterozygote; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary; D012376:Rodent Diseases / Q000453:epidemiology*; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary