[Effect of L-DOPA on the function of the brain neuromediator systems].
L-DOPA effects on the activities of enzymes controlling the neurotransmitters utilization: monoamine oxidases (MAO) A and B and acetylcholinesterase (AChE) were demonstrated in synaptosomes and mitochondria of the cells in sensorimotor cortex and caudate nucleus. Sixty minutes after a single dose of L-DOPA the MAO and AChE activities were virtually unchanged in subfractions of both brain regions. After a prolonged (30 days) treatment (1000 mg/kg total dose) MAO B activity increased whereas the MAO B and AChE activities decreased only in cortical synaptosomes and mitochondria. The data suggest that under effect of L-DOPA a definite reciprocity arises in the neurotransmitter catabolic systems in a specific manner for each brain structure.
Lovedova
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D000110:Acetylcholinesterase / Q000378:metabolism; D017109:Akathisia, Drug-Induced; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002421:Caudate Nucleus / Q000187:drug effects / Q000201:enzymology; D007980:Levodopa / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism; D009044:Motor Cortex / Q000187:drug effects / Q000201:enzymology; D009490:Neurosecretory Systems / Q000187:drug effects* / Q000201:enzymology; D011595:Psychomotor Agitation / Q000201:enzymology; D011817:Rabbits; D013574:Synaptosomes / Q000187:drug effects / Q000201:enzymology
D007980:Levodopa; D008995:Monoamine Oxidase; D000110:Acetylcholinesterase
O vliianii L-DOFA na sostoianie neĭromediatornykh sistem mozga.