Cultured epithelial cells derived from human foetal pancreas as a model for the study of cystic fibrosis: further analyses on the origins and nature of the cell types.
The establishment of a tissue-culture system for epithelial cells derived from human foetal pancreas has recently been reported. Further analyses have now been made on these cells in vitro, together with parallel investigation of the distribution of different cell types within the intact foetal pancreas. Results support the view that the cultured cells are ductal in origin and nature. Pancreatic epithelial cell cultures have also been established from foetuses with cystic fibrosis.
Harris
A
A
Paediatric Research Unit, UMDS, Guy's Hospital, London, UK.
Coleman
L
L
D002478:Cells, Cultured; D003550:Cystic Fibrosis / Q000473:pathology*; D004847:Epithelial Cells; D006801:Humans; D008954:Models, Biological; D010179:Pancreas / Q000166:cytology / Q000196:embryology*