title: In vivo estimation of left ventricular wall volume in volume-overloaded canine hearts.
abstract: Several geometric algorithms have been applied to estimate left ventricular wall volume (Vwall) from two-dimensional echocardiograms but have not been validated in eccentrically hypertrophied hearts. These algorithms can be fitted to the general formula: Vwall = k.Ao.Lo = k.Ai.Li, where Ao and Ai are the outer (epicardial) and inner (endocardial) short-axis areas, Lo and Li are the corresponding long-axis lengths, and k is a constant. The simplifying assumption that Lo and Li are equal yields Vwall = k.Awall.Lo, where Awall = Ao - Ai. In 20 unsedated dogs (10-30 kg), including 10 with aortic regurgitation of 1-18 wk duration, the relationship between actual Vwall (determined postmortem) and Awall.Lo was not significantly different from the line of identity (Vwall = 1.01 Awall.Lo + 0.5 ml, r = 0.98, SEE = 3.5 ml), indicating k was not significantly different from 1. There was no significant difference between predicted and actual Vwall over a range of 31-105 ml, and interobserver variability was 4.1%. The simple area-length product, Awall.Lo, accurately predicts Vwall of both normal and volume-overloaded hypertrophied canine left ventricles and is thus suitable for serial observations of hypertrophic adaptation to volume overload.
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: M P
authors.initials: MP
authors.lastname: Feneley
authors.forename: J W
authors.initials: JW
authors.lastname: Gaynor
authors.forename: G W
authors.initials: GW
authors.lastname: Maier
authors.forename: S A
authors.initials: SA
authors.lastname: Gall
authors.forename: J A
authors.initials: JA
authors.lastname: Kisslo
authors.forename: J S
authors.initials: JS
authors.lastname: Rankin
mesh_terms: D000465:Algorithms; D000818:Animals; D003971:Diastole; D004285:Dogs; D004452:Echocardiography; D006321:Heart / Q000033:anatomy & histology*; D006352:Heart Ventricles / Q000033:anatomy & histology; D008962:Models, Theoretical; D012016:Reference Values; D013599:Systole; D016276:Ventricular Function