[Comparative study of the progestagenic action of 16 alpha, 17 alpha-cyclohexanoprogesterones (pregna-D'6-pentarans) when administered by different routes].
A comparative study of the progestational activity of modified pentarans depending on the dose and the route of administration was carried out. It was shown that modification of the molecule of 16 alpha, 17 alpha-cyclohexanoprogesterones by introducing and additional double bond in positions 6, 7 and methyl group in position 6 provided a high gestational effect, being particularly pronounced at intramuscular administration.
Nikitina
G V
GV
Korkhov
V V
VV
Kulikova
L E
LE
Levina
I S
IS
Kamernitskiĭ
A V
AV
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004717:Endometrium / Q000187:drug effects / Q000378:metabolism; D005260:Female; D007273:Injections, Intramuscular; D009644:Norgestrel / Q000494:pharmacology; D011374:Progesterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D045167:Progesterone Congeners / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship
D045167:Progesterone Congeners; D009644:Norgestrel; D011374:Progesterone
Sravnitel'noe izuchenie progestagennogo deĭstviia 16 al'fa, 17 al'fa-tsiklogeksanoprogesteronov (pregna-D'6-pentaranov) pri razlichnykh putiakh vvedeniia.