Inhibitory effect of a mixture of herbal drugs (TJ-960, SK) on pentylenetetrazol-induced convulsions in E1 mice.
TJ-960 is a spray-dried mixture of 9 herbal drugs. The convulsions of E1 mice induced by pentylenetetrazol (18 mg/kg) were completely inhibited by p.o. administration of TJ-960 at a daily dose of 1.0 g/kg both in 8-week-old and 4-week-old E1 mice. These findings suggest that TJ-960 has an inhibitory effect on the convulsions of this hereditary animal model of epilepsy.
Sugaya
E
E
Department of Physiology, Kanagawa Dental College, Yokosuka, Japan.
Ishige
A
A
Sekiguchi
K
K
Iizuka
S
S
Sugimoto
A
A
Yuzurihara
M
M
Hosoya
E
E
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D051379:Mice; D008818:Mice, Neurologic Mutants; D010433:Pentylenetetrazole; D008517:Phytotherapy; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology
D000927:Anticonvulsants; D004365:Drugs, Chinese Herbal; C461321:shosaikoto-go-keishika-shakuyakuto; D010433:Pentylenetetrazole