[Apha-tocopherol in a complex with dimethyl sulfoxide--an agent possessing highly effective adaptogenic action in chronic emotional-pain stress in rats].
Alpha-tocopherol (5 mg/kg) administered perorally with dimethyl sulfoxide (50 mg/kg) in chronic emotional pain stress in rats possesses an effective antistress action, exceeding the effects of these drugs administered separately. Their prophylactic complex administration prevents the hypertension produced by stress, disturbance of reactivity of the vegetative nervous system during functional load, change of the behaviour in the open field. Adaptogenic action of the drugs is accompanied by a reduction of the content of free-radical oxidation products and by raising of superoxide scavenging activity in the brain and blood serum, by raising of phospholipids content, lowering of cholesterol content and of the ratio of cholesterol phospholipids in the brain extracts.
Levshina
I P
IP
Kurochkina
E V
EV
Obidin
A B
AB
Guliaeva
N V
NV
D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D002908:Chronic Disease; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051381:Rats; D012119:Respiration / Q000187:drug effects; D013315:Stress, Psychological / Q000188:drug therapy* / Q000503:physiopathology; D014810:Vitamin E / Q000627:therapeutic use*
D004338:Drug Combinations; D014810:Vitamin E; D004121:Dimethyl Sulfoxide
Al'fa-tokoferol v komplekse s dimetilsul'foksidom--sredstvo, obladaiushchee vysokoéffektivnym adaptogennym deĭstviem pri khronicheskom émotsional'no-bolevom stresse u krys.