Long-term observation of rats after unilateral intra-amygdaloid injection of kainic acid.
Electroencephalographic and clinical observations of the rats were done for 3 months after microinjection of kainic acid (KA, 0.2-1.2 micrograms) into the unilateral amygdala. With high doses of KA (0.6-1.2 micrograms) injection, 64% of rats developed spontaneous limbic seizures 14-25 days after KA injection. Among those which developed spontaneous limbic seizures, 33% of rats developed secondarily generalized seizures 26-71 days after KA injection. This is one of the best chronic models of spontaneous complex partial seizure secondarily generalized in rats, which is economical and easy to prepare.
Tanaka
S
S
Department of Neurosurgery, Asahikawa Medical College, Japan.
Kondo
S
S
Tanaka
T
T
Yonemasu
Y
Y
D000200:Action Potentials / Q000187:drug effects; D000679:Amygdala / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology
D007608:Kainic Acid