Antiepileptic effects of N6-L-phenylisopropyladenosine (L-PIA) on penicillin-induced epileptogenic focus in rabbits.
In the present work the effects of a stable analog of adenosine (N-6-L-phenylisopropyladenosine, L-PIA) have been investigated against the epileptic focus induced by intracortical injection of penicillin. The intracortical (i.c.) injection of penicillin (300 units) in rabbits elicits an epileptiform EEG and motor activity. Pretreatment with L-PIA (1.5 mg/kg i.v.) prevents the motor component of the epileptic phenomenon, while the EEG seizures are unaffected. The i.c. injection of L-PIA (20 nMoles in the left cortex), 10 minutes before penicillin (300 units in the right cortex) prevents the spreading of the epileptic activity from the right to the left hemisphere. These results suggest that adenosine might regulate the spreading of seizures. The possible role played by adenosine in the spontaneous arrest of epilepsy has also been discussed.
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Laboratorio di Farmacologia, Istituto Superiore di Sanità, Roma, Italy.
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Caporali
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Scotti de Carolis
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D000241:Adenosine / Q000031:analogs & derivatives*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D010406:Penicillins / Q000633:toxicity*; D010660:Phenylisopropyladenosine / Q000494:pharmacology*; D011817:Rabbits
D000927:Anticonvulsants; D010406:Penicillins; D010660:Phenylisopropyladenosine; D000241:Adenosine