title: Influence of diet with different lipid composition on neutrophil chemiluminescence and disease activity in patients with rheumatoid arthritis.
abstract: Neutrophil chemiluminescence was determined in patients with active rheumatoid arthritis. Twelve patients were randomly assigned either to a diet high in polyunsaturated fatty acids supplemented with eicosapentaenoic and docosahexaenoic acids or to a diet high in saturated fatty acids. A correlation with clinical and laboratory parameters is also reported. No statistical difference was observed in neutrophil chemiluminescence and in clinical parameters in the group of patients treated with a diet high in saturated fatty acids. Fish oil ingestion resulted in subjective alleviation of active rheumatoid arthritis and reduction of neutrophil chemiluminescence. This study corroborates the hypothesis of an anti-inflammatory role for polyunsaturated fatty acids in patients with chronic inflammatory diseases.
authors.affiliation: Internal Medicine Department, Catholic University, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Magaro
authors.forename: L
authors.initials: L
authors.lastname: Altomonte
authors.forename: A
authors.initials: A
authors.lastname: Zoli
authors.forename: L
authors.initials: L
authors.lastname: Mirone
authors.forename: P
authors.initials: P
authors.lastname: De Sole
authors.forename: G
authors.initials: G
authors.lastname: Di Mario
authors.forename: S
authors.initials: S
authors.lastname: Lippa
authors.forename: A
authors.initials: A
authors.lastname: Oradei
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology; D001799:Blood Sedimentation; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects*
chemical_list: D004042:Dietary Fats, Unsaturated