O-demethylpaulomycins A and B, U-77,802 and U-77,803, paulomenols A and B, new metabolites produced by Streptomyces paulus.
O-Demethylpaulomycin A (C33H44N2O17S), O-demethylpaulomycin B (C32H42N2O17S), paulomenol A (C29H43NO16), paulomenol B (C28H41NO16), and the hydrogen sulfide adducts of paulomycin A (U-77,802, C34H48N2O17S2), and paulomycin B (U-77,803, C33H46N2O17S2) have been isolated from fermentations of Streptomyces paulus strain 273. The structure of these compounds was determined by 1H and 13C NMR and fast atom bombardment mass spectrum spectroscopic techniques and degradative studies. The antibacterial properties of these new metabolites, which are related to paulomycins A and B (J. Antibiotics 35: 285-294, 1982), are briefly discussed.
Argoudelis
A D
AD
Research Laboratories, Upjohn Company, Kalamazoo, Michigan 49001.
Baczynskyj
L
L
Mizsak
S A
SA
Shilliday
F B
FB
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D053138:Cyclohexenes; D004187:Disaccharides / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism
D000900:Anti-Bacterial Agents; D053138:Cyclohexenes; D004187:Disaccharides; C057873:O-demethylpaulomycin B; C057871:O-demethylpaulomycin A; C057877:U 77803; C057876:U 77802; C057874:paulomenol A; C057875:paulomenol B