High intensity light exposure increases blood-brain barrier transport in rats.
A quantitative technique utilizing 14C-alpha-aminoisobutyric acid as a tracer was used to study the blood-brain barrier permeability modifications induced by environmental stimuli, as the high intensity light exposure. The blood-to-brain transfer constant was significantly increased only in the occipital cortex following the treatment. The possibility that the blood-brain barrier is able to modify its local characteristics in response to cerebral activity changes was discussed.
Saija
A
A
Dipartimento Farmaco-Biologico, School of Pharmacy, University of Messina, Italy.
Princi
P
P
De Pasquale
R
R
Costa
G
G
D000621:Aminoisobutyric Acids; D000818:Animals; D001812:Blood-Brain Barrier / Q000528:radiation effects*; D002199:Capillary Permeability / Q000528:radiation effects; D008027:Light; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000621:Aminoisobutyric Acids; C100049:2-aminoisobutyric acid