Experimental infection in a human subject by a possibly undescribed species of Taenia in Taiwan.
A cysticercus of a possibly undescribed species of Taenia which occurs commonly in Taiwan aborigines was used to establish an experimental infection in a human volunteer. Symptomatic effects attributed to the infection included diarrhoea, upper abdominal pain, and increase or loss of appetite over a four-month period. After an expelled proglottid was observed 122 days post-exposure, eggs and proglottids were found continuously until the patient was treated with anthelmintics. Antibody titres measured by enzyme-linked immunosorbent assay and levels of eosinophilia seemed to correlate with symptoms. Haematological analyses revealed an abnormal lipid metabolism during the entire symptomatic period.
Chao
D
D
Department of Parasitology, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China.
Wong
M M
MM
Fan
P C
PC
D000328:Adult; D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis; D002417:Cattle; D002707:Chlordiazepoxide / Q000627:therapeutic use; D003551:Cysticercosis / Q000097:blood / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology*; D004338:Drug Combinations / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay; D004802:Eosinophilia / Q000469:parasitology; D006805:Human Experimentation; D006801:Humans; D008297:Male; D011796:Quinacrine / Q000627:therapeutic use; D011812:Quinuclidines / Q000627:therapeutic use
D000909:Antibodies, Helminth; D004338:Drug Combinations; D011812:Quinuclidines; D002707:Chlordiazepoxide; C034153:chlordiazepoxide, clidinium drug combination; D011796:Quinacrine