title: False negative findings at third trimester chorionic villus sampling (C.V.S.).
abstract: A discrepancy is reported between the karyotypes of chorionic cells (direct method):46,XX and of cultured amniotic fluid cells: 47,XX, + 18 in a pregnancy of 30 weeks. A stillborn girl, with external signs of trisomy 18 syndrome, was subsequently shown to have a mosaic pattern in both the lymphocytes and the placenta.
authors.affiliation: Department of Human Genetics, University of Amsterdam, The Netherlands.
authors.forename: N J
authors.initials: NJ
authors.lastname: Leschot
authors.forename: H
authors.initials: H
authors.lastname: Wolf
authors.forename: G H
authors.initials: GH
authors.lastname: Weenink
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis*; D000328:Adult; D000653:Amniotic Fluid / Q000166:cytology; D015193:Chorionic Villi Sampling; D002887:Chromosomes, Human, Pair 18; D005188:False Negative Reactions; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D014314:Trisomy