title: Age-related changes of muscimol binding in the substantia nigra.
abstract: Receptor binding studies of the substantia nigra (SN) and cerebellum revealed two affinity sites for muscimol binding in the SN and cerebellum of adult and 16-day-old rats. Scatchard analysis revealed a paucity of high-affinity muscimol receptors in the SN of 16-day-old rat pups. These results suggest that the lack of anticonvulsant action of muscimol in the SN of 16-day-old rat pups may be due to the paucity of high-affinity muscimol receptors as compared to adult rats.
authors.affiliation: Department of Neurology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461.
authors.forename: J N
authors.initials: JN
authors.lastname: Wurpel
authors.forename: A
authors.initials: A
authors.lastname: Tempel
authors.forename: E F
authors.initials: EF
authors.lastname: Sperber
authors.forename: S L
authors.initials: SL
authors.lastname: Moshé
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D002531:Cerebellum / Q000254:growth & development / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009118:Muscimol / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000254:growth & development / Q000378:metabolism*
chemical_list: D009118:Muscimol