[Functional changes in the bronchoalveolar macrophages during the development of long-term radiation-induced pulmonary complications].
The right hemithorax of albino rats was subjected to irradiation of 14.3 Gy at a single dose of 2.2 Gy/min. Local macrophages (BM) were lavaged and studied at different time-points (1 day to 6 mos.) following irradiation. During the phase of radiation pneumonitis, BM activation was revealed, according to an increase in the spreading index, DNA relaxation, enhanced phagocytic capacity of isologous thymocytes. Six months after treatment (the phase of lung fibrosis), the yield of BM from affected lungs was increased along with a diminished percentage of cells capable of phagocytizing dead thymocytes. A phasic time-dependence of BM changes in the postirradiation period was discussed.
Zherbin
E A
EA
Chukhlovin
A B
AB
Vashchenko
V I
VI
D000818:Animals; D002448:Cell Adhesion / Q000528:radiation effects; D002452:Cell Count / Q000528:radiation effects; D004278:DNA, Superhelical / Q000528:radiation effects; D008168:Lung / Q000166:cytology / Q000528:radiation effects*; D008264:Macrophages / Q000502:physiology / Q000528:radiation effects*; D008297:Male; D010587:Phagocytosis / Q000528:radiation effects*; D051381:Rats; D013997:Time Factors
D004278:DNA, Superhelical
Funktsional'nye izmeneniia bronkhoal'veoliarnykh makrofagov pri razvitii pozdnykh luchevykh legochnykh oslozhneniĭ.