Topically applied cyclosporin for modulation of induced immunogenic uveitis in rabbits.
The experimental model of immunogenic uveitis induced by intraocular injection of human serum albumin in rabbits was inhibited by the topical application of cyclosporin A. The acute nonspecific inflammatory response that immediately follows intravitreous injection was not affected. However, the severe panuveitis that develops during the second week was markedly reduced. The safety and efficacy of topically applied cyclosporin A in this model of uveitis suggests that topical administration of this antigen-nonspecific immunosuppressor may be an effective route of therapy for certain immune-mediated forms of uveitis.
Kaswan
R L
RL
Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
Kaplan
H J
HJ
Martin
C L
CL
D000287:Administration, Topical; D000818:Animals; D003524:Cyclosporins / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D011817:Rabbits; D012709:Serum Albumin; D014605:Uveitis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*
D003524:Cyclosporins; D012709:Serum Albumin