title: [Decreased capacity of the peripheral blood lymphocytes for excisional DNA repair in disseminated sclerosis].
abstract: In patients with multiple sclerosis the reduction of DNA excision reparation capacity of peripheral blood lymphocytes was found to correlate with the disease severity but not with its duration. These changes and the increase in the DNA reparative synthesis along with the lymphocytes DNA structural changes are considered as the evidence of impaired lymphocytes genome stability in this ailment. Their possible role in the development of immunodeficiency in multiple sclerosis is discussed.
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Moskaleva
authors.forename: I N
authors.initials: IN
authors.lastname: Tobolov
authors.forename: V G
authors.initials: VG
authors.lastname: Shumilov
authors.forename: T L
authors.initials: TL
authors.lastname: Demina
authors.forename: E F
authors.initials: EF
authors.lastname: Gorbunov
mesh_terms: D002478:Cells, Cultured; D004247:DNA / Q000097:blood* / Q000528:radiation effects; D004260:DNA Repair / Q000528:radiation effects; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism* / Q000528:radiation effects; D009103:Multiple Sclerosis / Q000097:blood*; D014466:Ultraviolet Rays
chemical_list: D004247:DNA
vernacular_title: Snizhenie sposobnosti limfotsitov perifericheskoĭ krovi k ékstsizionnoĭ reparatsii DNK pri rasseiannom skleroze.