Somatomedin-C and diabetic retinopathy.
To investigate the relationship between the plasma somatomedin-C level and diabetic retinopathy, especially in different stages of the disease, plasma somatomedin-C levels were measured in 72 patients with noninsulin-dependent diabetes mellitus accompanied by or without retinopathy and in 37 normal control subjects. The stage of retinopathy was assessed by ophthalmoscopy and fluorescein angiography. Plasma somatomedin-C levels were significantly greater in the diabetic patients with retinopathy than in the age-matched normal controls (P less than 0.01). Plasma somatomedin-C level in the patients with proliferative retinopathy was 0.60 +/- 0.30 (mean +/- SD) IU/ml (n = 24), which was significantly greater than that in the normal controls (0.41 +/- 0.18 IU/ml) (P less than 0.01). However, the patients in different stages of diabetic retinopathy did not differ significantly from each other in their plasma somatomedin-C levels.
Sato
K
K
Department of Ophthalmology, Osaka City University Medical School, Japan.
Ikeda
T
T
Miki
T
T
Nishizawa
Y
Y
Morii
H
H
D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D003930:Diabetic Retinopathy / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D005215:Fasting; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000097:blood*; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013002:Somatomedins / Q000097:blood*
D001786:Blood Glucose; D003404:Creatinine; D006442:Glycated Hemoglobin; D007334:Insulin-Like Growth Factor I; D013002:Somatomedins