Effects of zinc acexamate on gastric mucosal production of prostaglandin E2 in normal and stressed rats.
Changes in PGE2 levels induced by zinc acexamate (ZAC) at gastricmucosal level were assessed in a rat model. Experiments were performed in normal rats and rats subjected to cold-restraint stress and in experimental conditions in which prostaglandins (PGs) synthesis was inhibited by prior administration of indomethacin. Gastric injuries after different treatments were quantified macro and microscopically. Total amount of PGE2 and mucus material recovered from gastric mucosa were increased after ZAC treatment. Indomethacin aggravated gastric damage secondary to stress and inhibited PGE2 and mucus increase appearing after ZAC treatment. These data confirm the relation between PGE2, mucus production and gastric protection. ZAC 200 mg/kg was able to reduce the gastric damage induced by stress. This decrease was also evident in the group receiving indomethacin before ZAC administration. These experiments indicate that ZAC exhibits its antiulcer action by increasing prostaglandins but other mechanisms independent of PGs synthesis are also involved.
Navarro
C
C
Department of Pharmacology, Lab. Viñas, S.A., Barcelona, Spain.
Escolar
G
G
Baños
J E
JE
Casanovas
L I
LI
Bulbena
O
O
D000614:Aminocaproates / Q000494:pharmacology*; D015119:Aminocaproic Acid / Q000494:pharmacology*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003080:Cold Temperature; D015232:Dinoprostone / Q000096:biosynthesis*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D007213:Indomethacin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000378:metabolism*
D000614:Aminocaproates; C018802:6-acetylaminocaproic acid; D015232:Dinoprostone; D015119:Aminocaproic Acid; D007213:Indomethacin