Teratology study of Tween 60 in rats.
The teratogenicity of Tween 60 was studied in Wistar rats. Pregnant rats were given Tween 60 at a dose of 0, 0.1, 1.0 or 10% in the diet from day 7 to day 14 of pregnancy. Daily intakes of Tween 60 were 99 mg/kg for the 0.1% group, 960 mg/kg for the 1.0% group and 7693 mg/kg for the 10% group. No change induced by Tween 60 was detected in the number, sex ratio and body weight of live fetuses. External, skeletal and internal examinations of the fetuses revealed no evidence of teratogenesis. It could be concluded that Tween 60 has no harmful effects on the prenatal development of the rat offspring at doses employed in the present study.
Ema
M
M
National Institute of Hygienic Sciences, Osaka, Japan.
Itami
T
T
Kawaski
H
H
Kanoh
S
S
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D008098:Litter Size / Q000187:drug effects; D011136:Polysorbates / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012744:Sex Ratio; D013723:Teratogens
D011136:Polysorbates; D013723:Teratogens