[The 2-phase action on mice of immunoglobulins isolated from the blood of a myasthenia patient].
Single injection of Ig preparations from the myasthenia-patient-blood on C57Bl mice, revealed two phases in the development of the myasthenic syndrome. The first phase started one-two hours after the injection only of the IgM preparation in a dose 2-10 mg. This phase was in progress for two days. The second phase developed during the injection of either the Igm or IgG preparations in a dose 6-10 mg (IgG) of 2-10 mg (IgM). This phase was characterized by the appearance of long myasthenic disorders in two-three week time after the experiment. Some of these mice perished. It was assumed that the absence of strict correlation between the concentration of anti-AChR-IgG antibodies and the gravity of myasthenia is connected with the IgM participation in the pathogenesis of the myasthenia and/or with the appearance of secondary autoantibodies towards the targets which differ from AChR's myoneural synapsis.
Smirnov
V A
VA
Saĭkova
L A
LA
Lobzin
V S
VS
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000276:immunology* / Q000302:isolation & purification; D007075:Immunoglobulin M / Q000276:immunology* / Q000302:isolation & purification; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009157:Myasthenia Gravis / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D009388:Neostigmine / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000187:drug effects / Q000276:immunology
D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009388:Neostigmine
O dvukhfaznom deĭstvii na mysheĭ immunoglobulinov, vydelennykh iz krovi bol'nogo miastenieĭ.