title: Colchicine treatment in a case of pachydermoperiostosis with acroosteolysis.
abstract: We report a case of pachydermoperiostosis with arthralgia, acroosteolysis, and recurrent staphylococcal folliculitis of the face, treated with colchicine (0.5 mg once daily for the 1st week and 0.5 mg twice daily for the next 3 weeks). The evaluation of arthralgia, hyponchial angle, folliculitis, and pachyderma, performed at basal time and once weekly, showed improvement of symptoms and signs after 7-15 days of treatment. Neutrophilic chemotaxis, evaluated before starting the treatment and after 15 and 30 days of therapy, showed a progressive decrease of the initial very high index. Colchicine provided a beneficial therapeutic response in both inhibiting increased chemotactic activity and in reducing tissular oedema in our patient.
authors.affiliation: Istituto di Clinica Medica IV, Università di Firenze, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Matucci-Cerinic
authors.forename: L
authors.initials: L
authors.lastname: Fattorini
authors.forename: G
authors.initials: G
authors.lastname: Gerini
authors.forename: A
authors.initials: A
authors.lastname: Lombardi
authors.forename: A
authors.initials: A
authors.lastname: Pignone
authors.forename: N
authors.initials: N
authors.lastname: Petrini
authors.forename: T
authors.initials: T
authors.lastname: Lotti
mesh_terms: D000328:Adult; D002633:Chemotaxis / Q000187:drug effects; D003078:Colchicine / Q000627:therapeutic use*; D005385:Fingers / Q000000981:diagnostic imaging; D006801:Humans; D007596:Joints; D008297:Male; D010004:Osteoarthropathy, Primary Hypertrophic / Q000150:complications / Q000188:drug therapy*; D010014:Osteolysis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010146:Pain / Q000150:complications / Q000188:drug therapy; D011859:Radiography; D012871:Skin Diseases / Q000150:complications / Q000188:drug therapy; D014034:Toes
chemical_list: D003078:Colchicine