Dexfenfluramine and body weight regulation: experimental study with hoarding behavior.
At very low doses dexfenfluramine, a serotonin agonist, is a potent inhibitor of hoarding behavior. The dose able to suppress 40% of this food motivated response (ED 40) is approximately 0.3 mg/kg. The action of dexfenfluramine is mediated through serotoninergic receptors because it is suppressed by a pretreatment with metergoline, a selective serotonin-receptor blocker, but is not modified by haloperidol, a dopamine antagonist.
Fantino
M
M
Laboratoire de Neurobiologie des Comportements Alimentaires, Université de Bourgogne, Faculté de Médecine de Dijon, France.
Boucher
H
H
Faïon
F
F
Mathiot
P
P
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D005277:Fenfluramine / Q000494:pharmacology*; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects
D011985:Receptors, Serotonin; D005277:Fenfluramine