title: Upper and lower reproductive tract bacteria in 126 women with acute pelvic inflammatory disease. Microbial susceptibility and clinical response to four therapeutic regimens.
abstract: To more clearly understand the microbiology of acute salpingitis in our patients and to evaluate the clinical efficacy and safety of recommended and new therapeutic regimens, 126 women who met clinical diagnostic criteria for acute community-acquired pelvic inflammatory disease underwent endocervical and endometrial cultures prior to random intravenous therapy with cefoxitin plus doxycycline, ceftizoxime plus doxycycline or ceftizoxime alone (two regimens). Nine women (7%) had Chlamydia, and 70 (56%) had gonococci in endometrial specimens (P less than .001). Only two women (3.4%) given monotherapy required altered medical therapy, and none required surgery. Parenteral combination therapy was associated more frequently with adverse clinical and laboratory events.
authors.affiliation: Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Parkland Memorial Hospital, Dallas 75235-9032.
authors.forename: D L
authors.initials: DL
authors.lastname: Hemsell
authors.forename: B J
authors.initials: BJ
authors.lastname: Nobles
authors.forename: M C
authors.initials: MC
authors.lastname: Heard
authors.forename: P G
authors.initials: PG
authors.lastname: Hemsell
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D002440:Cefoxitin / Q000008:administration & dosage; D015296:Ceftizoxime / Q000008:administration & dosage; D004318:Doxycycline / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D004716:Endometritis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D011446:Prospective Studies; D011897:Random Allocation; D012488:Salpingitis / Q000188:drug therapy / Q000382:microbiology*; D002575:Uterine Cervicitis / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D002440:Cefoxitin; D015296:Ceftizoxime; D004318:Doxycycline