Cloning of a membrane protein that induces a slow voltage-gated potassium current.
A rat kidney messenger RNA that induces a slowly activating, voltage-dependent potassium current on its expression in Xenopus oocytes was identified by combining molecular cloning with an electrophysiological assay. The cloned complementary DNA encodes a novel membrane protein that consists of 130 amino acids with a single putative transmembrane domain. This protein differs from the known ion channel proteins but is involved in the induction of selective permeation of potassium ions by membrane depolarization.
Takumi
T
T
Institute for Immunology, Kyoto University Faculty of Medicine, Japan.
Ohkubo
H
H
Nakanishi
S
S
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004553:Electric Conductivity; D008564:Membrane Potentials; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D015221:Potassium Channels / Q000502:physiology*; D051381:Rats; D014982:Xenopus laevis
D008565:Membrane Proteins; D015221:Potassium Channels; D004247:DNA