Acute and repeated dose inhalation toxicity of para-nitrophenol sodium salt in rats.
Para-Nitrophenol Sodium Salt (PNSP) has relatively low acute inhalation toxicity; the 4-hr Approximate Lethal Concentration in rats is greater than 4.7 mg/l. One subacute study was conducted at 0, 0.34 and 2.47 mg PNSP/l for ten 6-hr exposures. Darker urine, proteinuria and elevated creatinine and SGOT were seen after exposure and were still evident after 14 days recovery. Methemoglobinemia also was seen and was reversible at 0.34 mg/l after 14 days. In addition, exposure to 2.47 mg/l caused elevated erythrocytes, hemoglobin and hematocrit. A second subacute study at 0.03 and 0.13 mg PNSP/l showed reversible methemoglobinemia only at 0.13 mg/l. The repeated dose no-observable effect level was 0.03 mg/l. No compound-related pathologic changes were noted in any of the studies.
Smith
L W
LW
Central Research and Development Department, E. I. du Pont de Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine, Newark, DE 19714.
Hall
G T
GT
Kennedy
G L
GL
D000280:Administration, Inhalation; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006403:Hematologic Tests; D008297:Male; D009596:Nitrophenols / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D051381:Rats
D009596:Nitrophenols; C024836:4-nitrophenol