Eosinophilic leucocytes and arylsulfatase activity in bronchoalveolar lavage fluid of patients with bronchial asthma.
The arylsulfatase activity and histamine concentration of bronchoalveolar lavage fluid (BALF) were examined in patients with bronchial asthma in relation to the eosinophil count and asthma type (atopic and non-atopic). The BALF arylsulfatase activity and histamine concentration were significantly higher in atopic asthmatics than in non-atopic asthmatics. In atopic asthmatics, the activity of arylsulfatase was significantly increased in patients with a higher eosinophil count (10% or more). However, the BALF histamine concentration did not correlate with the eosinophil count. In non-atopic asthmatics, there was no significant correlation between arylsulfatase activity and the eosinophil count. The results show that arylsulfatase participates in IgE-mediated allergic reactions.
Tanizaki
Y
Y
Department of Medicine, Misasa Medical Branch, Okayama University Medical School, Japan.
Sudo
M
M
Kitani
H
H
Araki
H
H
Oki
K
K
Tsuji
M
M
Takahashi
K
K
Kimura
I
I
D000328:Adult; D001192:Arylsulfatases / Q000378:metabolism*; D001249:Asthma / Q000201:enzymology*; D004112:Dimercaprol; D004804:Eosinophils / Q000502:physiology*; D006632:Histamine / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000201:enzymology; D007073:Immunoglobulin E; D007958:Leukocyte Count; D008168:Lung / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D013429:Sulfatases / Q000378:metabolism*
D004112:Dimercaprol; D007073:Immunoglobulin E; D006632:Histamine; D013429:Sulfatases; D001192:Arylsulfatases