Haematology and serum biochemistry in the racing greyhound following intraperitoneal povidone-iodine.
Povidone-iodine caused peritonitis with neutrophilic leukocytosis and a minimal left shift at the dosage rate of 3.5 ml/kg body weight. A dosage rate of 2 ml/kg only caused slight neutrophilic leukocytosis. There was a significant increase in the levels of creatinine (p = 0.049) and BUN (p = 0.020) in dogs that received the higher dose rate. Two dogs died from povidone-iodine toxicity with a marked increase in ALT, AP, SDH and conjugated bilirubin. It is concluded that povidone-iodine is unsafe for use in the peritoneal cavity of dogs.
Ndikuwera
J
J
Faculty of Veterinary Science, University of Zimbabwe, Harare.
Winstanley
E W
EW
Binta-Mushi
G
G
Mushi
E Z
EZ
D000818:Animals; D001806:Blood Urea Nitrogen; D056486:Chemical and Drug Induced Liver Injury; D003404:Creatinine / Q000097:blood; D004283:Dog Diseases / Q000097:blood / Q000139:chemically induced*; D004285:Dogs; D005260:Female; D007274:Injections, Intraperitoneal / Q000662:veterinary; D007964:Leukocytosis / Q000097:blood / Q000139:chemically induced / Q000662:veterinary*; D008107:Liver Diseases / Q000097:blood / Q000662:veterinary*; D008297:Male; D009504:Neutrophils; D010538:Peritonitis / Q000097:blood / Q000139:chemically induced / Q000662:veterinary*; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*
D011206:Povidone-Iodine; D003404:Creatinine; D011205:Povidone