title: Brain-specific src oncogene mRNA mapped in rat brain by in situ hybridization.
abstract: Brain src protooncogene is expressed in two forms, one identical to message in other tissues, and one containing an 18-nucleotide insert specific to brain. We have mapped mRNA for the two forms of src in rat brain with selective antisense oligonucleotide probes to the brain (src+) and peripheral (src-) forms. Fetal rat src mRNA levels were much higher in the central nervous system than any peripheral organ. In adult brain, src+ mRNA level was highest in the internal granular layer of the olfactory bulb, pyramidal cells of the hippocampus, granule cells of the dentate gyrus, and cerebellar granule cells. src+ and src- levels were similar in hindbrain, but src+ levels were higher than those of src- in forebrain. These distributions suggest that src+ may play roles in a number of neural processes, possibly including neuronal plasticity.
authors.affiliation: Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
authors.forename: C A
authors.initials: CA
authors.lastname: Ross
authors.forename: G E
authors.initials: GE
authors.lastname: Wright
authors.forename: M D
authors.initials: MD
authors.lastname: Resh
authors.forename: R C
authors.initials: RC
authors.lastname: Pearson
authors.forename: S H
authors.initials: SH
authors.lastname: Snyder
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D002874:Chromosome Mapping; D006651:Histocytochemistry; D008297:Male; D015335:Molecular Probes; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D015335:Molecular Probes; D012333:RNA, Messenger