Maternal phenylketonuria: successful outcome in four pregnancies treated prior to conception.
The management of four pregnancies in two phenylketonuric women is described. A successful outcome in these pregnancies is ascribed to the initiation of treatment prior to conception and the maintenance of tight control with serum phenylalanine between 100 and 400 mumol/l throughout the gestation period. A trial of diet is desirable before a decision is made about pregnancy and before contraception is ceased. Close contact must be maintained with female phenylketonurics throughout their reproductive life to ensure that this process is followed.
Lynch
B C
BC
Phenylketonuria Clinic, Royal Children Hospital, Melbourne, Victoria, Australia.
Pitt
D B
DB
Maddison
T G
TG
Wraith
J E
JE
Danks
D M
DM
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D010649:Phenylalanine / Q000097:blood; D010661:Phenylketonurias / Q000178:diet therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000178:diet therapy*; D014443:Tyrosine / Q000097:blood
D014443:Tyrosine; D010649:Phenylalanine