title: Cardiotoxic manifestations of mesoridazine overdose.
abstract: We present a case of malignant arrhythmias associated with hypocalcemia and subsequent cardiac arrest in a 20-year-old woman due to ingestion of 3.1 g mesoridazine in a suicide attempt. There were unexplained alterations in serum electrolytes preceding the cardiac arrest. The patient subsequently recovered and was transferred to a psychiatric hospital. Despite the paucity of data on the potential cardiotoxicity associated with mesoridazine overdose, this case demonstrates that malignant arrhythmias and cardiac arrest occur; consequently, these patients probably require constant ECG monitoring.
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, University of Illinois, Chicago 60612.
authors.forename: P A
authors.initials: PA
authors.lastname: Marrs-Simon
authors.forename: M
authors.initials: M
authors.lastname: Zell-Kanter
authors.forename: D L
authors.initials: DL
authors.lastname: Kendzierski
authors.forename: J B
authors.initials: JB
authors.lastname: Leikin
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D004562:Electrocardiography; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D008653:Mesoridazine / Q000506:poisoning*; D013406:Suicide, Attempted
chemical_list: D008653:Mesoridazine