[Conformation possibilities of the lipotropic acton of human somatotropin].
Using a semiempirical conformational analysis, a three-dimensional structure and conformational properties of human somatotropin free lipotropical action and fragment 31-44 possessing identical amino acid sequences were investigated. The calculations were performed on the basis of the fragmental analysis, using nonvalent, electrostatic and torsional interactions and hydrogen bonds. The data obtained suggest that these molecules can exist only in several low energy conformations. The conformational possibilities of the free acton molecule and fragment 31-44 differ essentially. The experimental results can be used for the study of structure-function relationships.
Mzareulov
K D
KD
D000595:Amino Acid Sequence; D013006:Growth Hormone / Q000032:analysis*; D006801:Humans; D008053:Lipid Mobilization; D010446:Peptide Fragments / Q000032:analysis*; D011487:Protein Conformation
D010446:Peptide Fragments; D013006:Growth Hormone
Konformatsionnye vozmozhnosti molekuly lipotropnogo aktona somatotropina cheloveka.