The fate of leached di-(2-ethylhexyl)-phthalate (DEHP) in patients on chronic haemodialysis.
The fate of the plasticiser di-(2-ethylhexyl)-phthalate and/or its metabolites, phthalic acid esters (PAE), in 12 patients on chronic haemodialysis was studied. The total amount of PAE retained by the patients was estimated by monitoring the plasma concentrations from the inflow and outflow tubes of the dialyzer during 4-h dialysis sessions. There was an estimated uptake of 46 mg of PAE during a single dialysis session. The values for a volumetric factor (Vf) related to the increment in plasma PAE concentrations were found to increase during the first hour of treatment (72 litres at steady-state), and then to progressively decrease. The changes in the kinetic parameters during the dialysis session were grouped into three phases according to the fate of the plasticiser in the patient. We also monitored the plasma concentrations of PAE in the same patients for 40 days during dialysis with another kind of plasticised (tri-(2-ethylhexyl)-trimellitate [TOTM]) tubes. The PAE concentrations were similar to those found in healthy humans after about 5 weeks.
Flaminio
L M
LM
Institute of Pharmacological Sciences, University of Milan, Italy.
Bergia
R
R
De Angelis
L
L
Ferazza
M
M
Marinovich
M
M
Galli
G
G
Galli
C L
CL
D000328:Adult; D000368:Aged; D004051:Diethylhexyl Phthalate / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007688:Kidneys, Artificial; D008297:Male; D008875:Middle Aged; D010795:Phthalic Acids / Q000493:pharmacokinetics*; D006435:Renal Dialysis; D013997:Time Factors
D010795:Phthalic Acids; D004051:Diethylhexyl Phthalate