title: Alkylation of haemoglobin, plasma proteins and DNA in the mouse by diethylnitrosamine.
abstract: Covalent binding to haemoglobin, plasma proteins and DNA was determined after intraperitoneal administration of radiolabelled diethylnitrosamine to mice. The level of alkylation of DNA in liver--the main site of activation--was found to be about two orders of magnitude higher than the level of alkylation of haemoglobin, if compared per unit weight of macromolecule. A high reactivity towards nucleophilic oxygen atoms was characteristic of the reaction pattern. Carboxylic acid ethyl esters, ethylserine and ethylthreonine are important reaction products in the proteins.
authors.affiliation: Department of Radiobiology, Stockholm University, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Osterman-Golkar
authors.forename: E
authors.initials: E
authors.lastname: Bergmark
mesh_terms: D000478:Alkylation; D000818:Animals; D001798:Blood Proteins; D004249:DNA Damage; D004052:Diethylnitrosamine; D004128:Dimethylnitrosamine; D004305:Dose-Response Relationship, Drug; D006454:Hemoglobins; D008099:Liver / Q000032:analysis; D051379:Mice
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins; D004052:Diethylnitrosamine; D004128:Dimethylnitrosamine