Puberty modifies sulpiride effects on body weight in rats.
Sulpiride (20 mg/kg, i.p.) for 21 days increased body weight in prepubertal, peripubertal and adult female rats. The increment was higher in the adult group, where a significant hyperphagia was also noted. In males, the same treatment tended to decrease body weight in the peripubertal and adult groups while in the prepubertal animals an increase of body weight without a significant hyperphagia was observed. These results are discussed in terms of an hypothetical sulpiride-induced reduction in serum gonadal steroid levels.
Baptista
T
T
Laboratorio de Fisiología de la Conducta, Facultad de Medicina, Universidad de Los Andes, Mérida, Venezuela.
Parada
M A
MA
Murzi
E
E
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013469:Sulpiride / Q000494:pharmacology*
D013469:Sulpiride