title: A phase I-II study of ifosfamide in combination with adriamycin in the treatment of adult soft tissue sarcoma.
abstract: Fifty-four patients with advanced soft tissue sarcoma were treated with a combination of ifosfamide (5 g/m2) and adriamycin (40-60 mg/m2) at 3 weekly intervals. Of the 50 evaluable patients a response was seen in 11 (22%) patients (3 complete and 8 partial responses), stabilization of disease occurred in 17 patients and the remaining 22 patients progressed whilst on treatment. Of the 22 patients receiving adriamycin 60 mg/m2 12 (55%) required a dose reduction due to toxicity compared to 11 (39%) of the 28 patients who received 40 mg/m2. For the patients who had a response the median relapse-free interval was 7 months (range 2-17+) and the overall median survival was 12 months (range 5-29+). The combination does not appear to show an advantage over either drug used as a single agent.
authors.affiliation: Sarcoma Unit, Royal Marsden Hospital, London, U.K.
authors.forename: J L
authors.initials: JL
authors.lastname: Mansi
authors.forename: C
authors.initials: C
authors.lastname: Fisher
authors.forename: E
authors.initials: E
authors.lastname: Wiltshaw
authors.forename: S
authors.initials: S
authors.lastname: MacMillan
authors.forename: M
authors.initials: M
authors.lastname: King
authors.forename: R
authors.initials: R
authors.lastname: Stuart-Harris
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000188:drug therapy* / Q000401:mortality; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000401:mortality
chemical_list: D004317:Doxorubicin; D007069:Ifosfamide