Visual acuities and dark-adapted thresholds of children with Bardet-Biedl syndrome.
We studied the visual acuities and dark-adapted sensitivities of 12 children with Bardet-Biedl syndrome. All except one child, who was seen only once, were tested serially. In the first decade of life, all visual acuities were within 2 octaves of normal. All but two final visual acuities obtained from patients in their second and third decades were more than 2 octaves poorer than normal. Dark-adapted sensitivities of all patients were, or became, significantly less than normal even in those patients whose period of follow-up was limited to the first decade of life. Of the 11 patients measured serially, seven showed decreases in dark-adapted sensitivities of at least 0.5 log unit during the follow-up period, and the last measured sensitivities of all patients were at least 2 log units less than the normal mean.
Leys
M J
MJ
Department of Ophthalmology, Children's Hospital, Boston, MA 02115.
Schreiner
L A
LA
Hansen
R M
RM
Mayer
D L
DL
Fulton
A B
AB
D002675:Child, Preschool; D003623:Dark Adaptation; D006801:Humans; D007849:Laurence-Moon Syndrome / Q000503:physiopathology*; D012044:Regression Analysis; D012684:Sensory Thresholds; D014792:Visual Acuity