title: Cytogenetic study of 105 children with acute lymphoblastic leukemia.
abstract: Cytogenetic analysis was performed on 105 children with acute lymphoblastic leukemia (ALL). Adequate mitoses for study were obtained in 79 of the cases (71%). A normal karyotype was found in 18 patients (23%), while clonal chromosomal abnormalities were detected in 61 patients (77%). The karyotypes fell into five categories according to modal number: normal (18 patients), pseudodiploid (27 patients), hypodiploid (3 patients), hyperdiploid with 47-50 chromosomes (11 patients), and hyperdiploid with greater than or equal to 51 chromosomes (20 patients). Structural chromosome changes were found in 50 patients (63%); translocations were encountered in 15 of these patients (19%). The chromosome most often participating in translocations was number 19. Modal number was found to be an independent prognostic factor. Modal numbers 47-50 were associated with the poorest prognosis. The hyperdiploid clone with more than 50 chromosomes and the normal karyotype had the best prognosis.
authors.affiliation: Department of Medical Genetics, University of Helsinki, Finland.
authors.forename: K
authors.initials: K
authors.lastname: Heinonen
authors.forename: J
authors.initials: J
authors.lastname: Rautonen
authors.forename: M A
authors.initials: MA
authors.lastname: Siimes
authors.forename: S
authors.initials: S
authors.lastname: Knuutila
mesh_terms: D000293:Adolescent; D000954:Antigens, Surface / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000235:genetics / Q000276:immunology; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000276:immunology; D011379:Prognosis
chemical_list: D000954:Antigens, Surface; D014408:Biomarkers, Tumor