title: Immunomodulating effect of neurotropin on delayed type hypersensitivity response in mice.
abstract: Effect of Neurotropin on the delayed type hypersensitivity (DTH) response to sheep red blood cells was examined in mice. Neurotropin suppressed the high DTH responses in ddY and BALB/c mice, while it enhanced the low DTH response in C57BL/6 mice when administered after sensitization. In addition, Neurotropin exerted a suppressive effect on the enhanced DTH response by cyclophosphamide pretreatment in C57BL/6 mice, but had a restorative effect on the suppressed DTH response in ddY mice loaded with restraint stress.
authors.affiliation: Department of Immunology and Allergy, Nippon Zoki Pharmaceutical Company, Hyogo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yoshii
authors.forename: T
authors.initials: T
authors.lastname: Matsuoka
authors.forename: Y
authors.initials: Y
authors.lastname: Kurimoto
authors.forename: S
authors.initials: S
authors.lastname: Suehiro
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011134:Polysaccharides / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; D011134:Polysaccharides; C010491:neurotropin