Hemodynamic effects of nifedipine in a canine model of acid aspiration.
A solution of ethyl alcohol, polyethylglycol, and distilled water that did (n = 5) or did not (n = 5) contain 250 micrograms/kg of the calcium channel blocker, nifedipine, was infused into the right atrium in 10 healthy mongrel dogs. Hydrochloric acid (pH = 1.8), 2 ml/kg, was then instilled into both lungs of all dogs via the tracheal tube. Hemodynamic data were collected before and 10 minutes after nifedipine was infused and 10, 45, 90 and 180 minutes after acid was instilled into the lungs. Gas exchange, including PaO2 and venous admixture, did not differ between the two groups. However, after aspiration, oxygen delivery significantly improved in the dogs given nifedipine compared to oxygen delivery in those not treated with nifedipine. We conclude that, despite significant decreases in PaO2 and venous admixture, nifedipine can restore oxygen delivery back to normal levels.
Griffeth
J K
JK
Department of Anesthesiology, University of Florida College of Medicine, Gainesville.
Gallagher
T J
TJ
Packer
D L
DL
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects*; D006851:Hydrochloric Acid; D009543:Nifedipine / Q000494:pharmacology*; D011015:Pneumonia, Aspiration / Q000139:chemically induced / Q000503:physiopathology*; D011659:Pulmonary Gas Exchange / Q000187:drug effects
D009543:Nifedipine; D006851:Hydrochloric Acid