Comparison of 123I monoclonal granulocyte antibody and 99Tcm-HMPAO-labelled leucocytes in the detection of inflammation.
Thirteen patients with a suspicion of bacterial infection or inflammatory disease were studied with 99Tcm-HMPAO-labelled leucocytes (99Tcm-WBC) and 123I-labelled monoclonal antibodies against granulocytes (123I-MoAb-gc) within 5 days of the first study. Images were obtained at 30-40 min, 3-5 and 20-24 h. The quality of 99Tcm-WBC images was superior to that of the 123I-MoAb-gc. Eight cases were negative with both agents. Six inflammatory or infectious sites in five patients were clearly positive with 99Tcm-WBC even at 30 min, becoming moderately or strongly positive at 3-5 h but only three of them were weakly positive with 123I-MoAb-gc. One cause of the poor result with 123I-MoAb-gc may be the quite low activity in granulocytes and high plasma activity. We cannot recommend 123I-MoAb-gc as a primary imaging agent for inflammatory or infectious diseases for which 99Tcm-WBC seems very useful.
Vorne
M
M
Päi jät-Häme Central Hospital, Lahti, Finland.
Karhunen
K
K
Lantto
T
T
Mokka
R
R
Mäkelä
P
P
Nikoskelainen
J
J
Rajamäki
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D001424:Bacterial Infections / Q000000981:diagnostic imaging; D005260:Female; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D010091:Oximes; D011877:Radionuclide Imaging; D013667:Technetium; D019690:Technetium Tc 99m Exametazime
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D013667:Technetium