title: Expression of the HST1 oncogene in human germ cell tumors.
abstract: HST1 (or HSTF1 in human gene nomenclature) is a transforming gene isolated from several cancerous and noncancerous cells. The HST1 protein is a heparin-binding growth factor with significant homology with human fibroblast growth factors and the mouse Int-2 protein. Here, we report the identification of expression of HST1 in a human teratoma cell line and in 5 out of 9 surgically resected human testicular germ cell tumors including seminomas and embryonal carcinomas. Mouse HST1 homologue was expressed in a certain stage of mouse embryo but not in postnatal mice.
authors.affiliation: National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Tsutsumi
authors.forename: H
authors.initials: H
authors.lastname: Sakamoto
authors.forename: K
authors.initials: K
authors.lastname: Miyagawa
authors.forename: S
authors.initials: S
authors.lastname: Teshima
authors.forename: T
authors.initials: T
authors.lastname: Sugimura
authors.forename: M
authors.initials: M
authors.lastname: Terada
mesh_terms: D000818:Animals; D004407:Dysgerminoma / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D051379:Mice; D009857:Oncogenes; D015347:RNA Probes; D013724:Teratoma / Q000235:genetics*; D013736:Testicular Neoplasms / Q000235:genetics
chemical_list: D015347:RNA Probes