Antitussive properties of levodropropizine.
The antitussive activity of levodropropizine (S(-)-3-(4-phenyl-piperazin-1-yl)-propane-1,2-diol, DF 526), was evaluated in anaesthetized guinea-pigs and rabbits and in unanaesthetized guinea-pigs. Levodropropizine was shown to have good antitussive activity. Intravenously, it was 1/10 to 1/20 as active as codeine and comparable to dropropizine, from which it is derived, on mechanically and electrically induced coughing in rabbits and guinea-pigs. After oral administration to the guinea-pig the antitussive activity of levodropropizine was comparable with those of both dropropizine and codeine against coughing induced by irritant aerosols.
Malandrino
S
S
Research & Development Laboratories, Dompé Farmaceutici S.p.A., Milan, Italy.
Melillo
G
G
Bestetti
A
A
Borsa
M
M
Giuliani
P
P
Tonon
G C
GC
D000284:Administration, Oral; D000818:Animals; D000996:Antitussive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003061:Codeine / Q000008:administration & dosage / Q000627:therapeutic use; D003371:Cough / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D006168:Guinea Pigs; D007275:Injections, Intravenous; D008297:Male; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use; D011409:Propylene Glycols / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits
D000996:Antitussive Agents; D010879:Piperazines; D011409:Propylene Glycols; C013341:zipeprol; C035916:dipropizine; D003061:Codeine