The flavonoid silymarin increases the permeability of rat bone marrow cells to (3H)-uridine.
The pretreatment of rats with the flavonoid silymarin increases the in vitro uptake of (3H)-uridine to bone marrow cell RNA. This stimulatory effect is unrelated to an increase in the activity of cellular polymerases. It is proposed that the flavonoid enhances the permeability of the cell to (3H)-uridine acting at the membrane level.
Garrido
A
A
Unidad de Bioquímica Farmacológica, INTA, Universidad de Chile, Santiago.
Guerra
R
R
Valenzuela
A
A
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012838:Silymarin / Q000494:pharmacology*; D012995:Solubility; D014529:Uridine / Q000378:metabolism*
D005419:Flavonoids; D012838:Silymarin; D014529:Uridine