title: [Function of the reproductive system in pre- and pubescent girls with diffuse toxic goiter and hypothyroidism].
abstract: Altogether 70 girls of pubertal age were examined: 50 with diffuse toxic goiter and 20 with hypothyrosis. A clinical picture of "hypoestrogenism" and menstrual disturbance confirmed by the results of clinical and gynecological examination and ultrasonic investigation was noted in the patients. A significant rise of the level of gonadotropic hormones correlating with the severity of disease, and a rise of the level of testosterone-estradiol binding protein were revealed. The results of the investigation suggest that changes in the reproductive system resulting from thyroid dysfunction age determined by disturbance of different links of hormonal regulation of the hypothalamo-hypophyseal-gonadal system.
authors.forename: T M
authors.initials: TM
authors.lastname: Varlamova
authors.forename: R N
authors.initials: RN
authors.lastname: Shchedrina
authors.forename: G D
authors.initials: GD
authors.lastname: Mataradze
mesh_terms: D000293:Adolescent; D002648:Child; D004967:Estrogens / Q000097:blood; D005260:Female; D006065:Gonadotropins, Pituitary / Q000097:blood; D006111:Graves Disease / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000503:physiopathology*; D008597:Menstrual Cycle; D011627:Puberty / Q000502:physiology*; D012098:Reproduction; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D004967:Estrogens; D006065:Gonadotropins, Pituitary; D012738:Sex Hormone-Binding Globulin; D013963:Thyroid Hormones
vernacular_title: Sostoianie reproduktivnoĭ sistemy u devochek pre- i pubertatnogo vozrasta s diffuznym toksicheskim zobom i gipotireozom.