title: In vitro comparison of aortic heart valve prostheses. Part 1: Mechanical valves.
abstract: The hydrodynamic performance of a series of mechanical heart valve prostheses is measured in the aortic position. All experiments are performed in an electrohydraulic, computer-controlled pulse duplicator simulating the left side of the human circulatory system. Testing conditions are set according to a Food and Drug Administration interlaboratory comparison protocol with cardiac outputs of 3.0, 4.5, 6.5, and 8.0 L/min at a constant heart rate of 70 beats/min. Mean systolic pressure differences, volume losses, and energy losses, as well as dimensionless pressure losses and energy loss coefficients, are calculated from the recorded pressure, volume, and flow tracings. The results of 10 mechanical heart valve prostheses (eight tilting disc valves and two bileaflet valves) are presented and their clinical relevance is discussed.
authors.affiliation: Helmholtz-Institute for Biomedical Engineering, Aachen University of Technology, Federal Republic of Germany.
authors.forename: E
authors.initials: E
authors.lastname: Knott
authors.forename: H
authors.initials: H
authors.lastname: Reul
authors.forename: M
authors.initials: M
authors.lastname: Knoch
authors.forename: U
authors.initials: U
authors.lastname: Steinseifer
authors.forename: G
authors.initials: G
authors.lastname: Rau
mesh_terms: D001021:Aortic Valve; D001794:Blood Pressure; D002306:Cardiac Volume; D006350:Heart Valve Prosthesis; D006801:Humans; D008955:Models, Cardiovascular; D013599:Systole