title: [Action of doxorubicin and a doxorubicin-heparin complex on the growth and metastasis of experimental tumors and the hemostatic system indices].
abstract: The electrophoretic and spectral analyses have been used to show the possibility to form a complex consisting of doxorubicin and adriamycin with heparin, the molar ratio being 6:1 and pH 4.8-7.4. Doxorubicin and adriamycin had procoagulant properties but the doxorubicin-heparin complex showed an anticoagulant activity. In experiments on rats with the Pliss lymphosarcoma and sarcoma 45 the doxorubicin-heparin complex depressed more efficiently the tumour growth and metastasis spreading. The combination of doxorubicin and the doxorubicin heparin complex with the trypsin-heparin complex which imitate the hyperfunction of anticoagulative system markedly increased the antitumour effects.
authors.forename: T M
authors.initials: TM
authors.lastname: Kalishevskaia
authors.forename: G V
authors.initials: GV
authors.lastname: Bashkov
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Repina
authors.forename: M V
authors.initials: MV
authors.lastname: Shpilevaia
authors.forename: L S
authors.initials: LS
authors.lastname: Modina
mesh_terms: D000818:Animals; D004317:Doxorubicin / Q000627:therapeutic use*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D006487:Hemostasis / Q000187:drug effects*; D006493:Heparin / Q000627:therapeutic use*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000188:drug therapy / Q000556:secondary; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000097:blood / Q000188:drug therapy* / Q000556:secondary; D051381:Rats; D012513:Sarcoma, Experimental / Q000097:blood / Q000188:drug therapy / Q000556:secondary; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D004317:Doxorubicin; D006493:Heparin
vernacular_title: Deĭstvie doksorubitsina i kompleksa doksorubitsin--geparin na rost i metastazirovanie éksperimental'nykh opukholeĭ i nekotorye pokazateli sistemy gemostaza.