title: Flight behavior induced by microinjection of GABA antagonists into periventricular structures in detelencephalated rats.
abstract: Behavioral effects of unilateral microinjections into periventricular structures of bicuculline, a classic GABA-A antagonist, and semicarbazide, a glutamic acid decarboxylase blocker, were studied in detelencephalated rats. These drugs produced a behavioral activation together with jumps. However, the characteristics of this behavioral activation differed as the injections were made in dorsal periaqueductal gray matter or medial hypothalamus. These data show close similarities to those observed with intact animals suggesting that GABA-A receptors are involved in the neural control of expression of flight behavior and functions in an intact manner and possibly independent of influences from forebrain structures. At variance with intact animals, these drugs produced contralateral turning behavior when locally injected into MH, pointing to some kind of inhibitory control exerted by telencephalic structures on the expression of circling behavior from diencephalic regions.
authors.affiliation: Laboratory of Psychobiology, F.F.C.L.R.P., University of São Paulo, Ribeirão Preto, Brasil.
authors.forename: C
authors.initials: C
authors.lastname: Tomaz
authors.forename: M
authors.initials: M
authors.lastname: Brandão
authors.forename: A
authors.initials: A
authors.lastname: Bagri
authors.forename: P
authors.initials: P
authors.lastname: Carrive
authors.forename: P
authors.initials: P
authors.lastname: Schmitt
mesh_terms: D000818:Animals; D001640:Bicuculline / Q000008:administration & dosage / Q000494:pharmacology*; D004924:Escape Reaction / Q000502:physiology*; D018756:GABA Antagonists; D007031:Hypothalamus; D007267:Injections; D008297:Male; D008845:Microinjections; D010487:Periaqueductal Gray; D051381:Rats; D011919:Rats, Inbred Strains; D012663:Semicarbazides / Q000008:administration & dosage / Q000494:pharmacology*; D013687:Telencephalon / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage
chemical_list: D018756:GABA Antagonists; D012663:Semicarbazides; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline