title: D2 dopamine receptors in rat striatum are homogeneous as revealed by ligand-binding studies.
abstract: D2 dopamine receptors in rat striatum have been analysed using the binding of [3H]domperidone. Competition experiments were performed with classical dopamine antagonists and antagonists reported by other workers to discriminate D2 dopamine receptor sub-classes. In all cases competition data conformed to a single binding site interaction so that there is no evidence for heterogeneity of the D2 dopamine receptor.
authors.affiliation: Department of Neuropharmacology, Glaxo Group Research Ltd., Ware, Hertfordshire, U.K.
authors.forename: M N
authors.initials: MN
authors.lastname: Leonard
authors.forename: C A
authors.initials: CA
authors.lastname: Halliday
authors.forename: A S
authors.initials: AS
authors.lastname: Marriott
authors.forename: P G
authors.initials: PG
authors.lastname: Strange
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D003024:Clozapine / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D004294:Domperidone / Q000378:metabolism; D008152:Loxapine / Q000378:metabolism; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism*; D013469:Sulpiride / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D011954:Receptors, Dopamine; C044629:DO 710; D004294:Domperidone; D013469:Sulpiride; D003024:Clozapine; D008152:Loxapine