[Plasma concentrations of clomipramine and its desmethyl metabolite in man. Methodologic limits].
The purpose of the present work was to study the correlations between clinical response and plasma concentrations of clomipramine or desmethylclomipramine, using two different methods of dosage: radio-immunoassay and high pressure liquid chromatography, compared with mass spectrometry method. The results vary according to the method used, suggesting that methodological problems might explain, at least partly, the discrepancies observed in the literature.
Piollet
I
I
Service de Psychiatrie A, CHU Saint-Jacques, Clermont-Ferrand.
Goyot
C
C
Paire
M
M
Touzery
A
A
Eschalier
A
A
Dehennin
L
L
Grenier
J
J
Lavarenne
J
J
Zarifian
E
E
D002851:Chromatography, High Pressure Liquid; D002997:Clomipramine / Q000031:analogs & derivatives* / Q000097:blood* / Q000378:metabolism / Q000627:therapeutic use; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D011863:Radioimmunoassay
C012273:desmethylclomipramine; D002997:Clomipramine
Etude des concentrations plasmatiques de la clomipramine et de son dérivé déméthylé chez l'homme. Limites méthodologiques.