title: Fragile (X) expression, age and the degree of intellectual handicap in the male.
abstract: The proportion of cells expressing the fra(X) was compared to the guardian's opinion of who was the "brighter" in 31 sibships of 2 or more affected males. Six fra(X) positive males in the normal workforce were compared in a similar way to other affected relatives. A correlation was found between lower values of expression and "brightness" by the Wilcoxson signed rank test (less than 0.01, 2-tail). A decline in fra(X) expression occurs with age. Some apparently normal non-expressing transmitting males may be accounted for by these findings.
authors.affiliation: Department of Medical Genetics, Prince of Wales Hospital, Sydney, Australia.
authors.forename: G
authors.initials: G
authors.lastname: Turner
authors.forename: M W
authors.initials: MW
authors.lastname: Partington
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005600:Fragile X Syndrome / Q000235:genetics / Q000523:psychology*; D006801:Humans; D007360:Intelligence; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012729:Sex Chromosome Aberrations / Q000523:psychology*