Dietary linoleic acid and the fatty acid profiles in rats fed partially hydrogenated marine oils.
The influence of the linoleic acid levels of diets containing partially hydrogenated marine oils (HMO) rich in isomeric 16:1, 18:1, 20:1 and 22:1 fatty acids on the fatty acid profiles of lipids from rat liver, heart and adipose tissue was examined. Five groups of rats were fed diets containing 20 wt % fat--16% HMO + 4% vegetable oils. In these diets, the linoleic acid contents varied between 1.9% and 14.5% of the dietary fatty acids, whereas the contents of trans fatty acids were 33% in all groups. A sixth group was fed a partially hydrogenated soybean oil (HSOY) diet containing 8% linoleic acid plus 32% trans fatty acids, mainly 18:1, and a seventh group, 20% palm oil (PALM), with 10% linoleic acid and no trans fatty acids. As the level of linoleic acid in the HMO diets increased from 1.9% to 8.2%, the contents of (n-6) polyunsaturated fatty acids (PUFA) in the phospholipids increased correspondingly. At this dietary level of linoleic acid, a plateau in (n-6) PUFA was reached that was not affected by further increase in dietary 18:2 (n-6) up to 14.5%. Compared with the HSOY- or PALM-fed rats, the plateau values of 20:4(n-6) were considerably lower and the contents of 18:2(n-6) higher in liver phosphatidylcholines (PC) and heart PC. Heart phosphatidylethanolamines (PE) on the contrary, had elevated contents of 20:4(n-6), but decreased 22:5(n-6) compared with the PALM group.(ABSTRACT TRUNCATED AT 250 WORDS)
Høy
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CE
Department of Biochemistry and Nutrition, Technical University of Denmark, Lyngby.
Hølmer
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D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis*; D005395:Fish Oils / Q000494:pharmacology*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism
D004041:Dietary Fats; D005227:Fatty Acids; D005395:Fish Oils; D008041:Linoleic Acids; D014280:Triglycerides; D019787:Linoleic Acid