title: Inhibition of platelet aggregation by an irreversible local anesthetic.
abstract: Three known local anesthetic agents were examined for their ability to inhibit platelet aggregation induced by adenosine diphosphate or epinephrine. Drug-treated platelet-rich plasma samples were filtered through agarose gel to remove free drug, and the ability of the platelets to aggregate was again determined. One of the local anesthetics contained a "one-armed" nitrogen mustard structure and appeared to produce an irreversible inhibition of aggregation. The other two agents gave a block of aggregation that was reversed upon gel filtration.
authors.affiliation: Department of Medicinal Chemistry, Medical College of Virginia, Virginia Commonwealth University, Richmond.
authors.forename: J F
authors.initials: JF
authors.lastname: Stubbins
authors.forename: C
authors.initials: C
authors.lastname: Pearson
authors.forename: G D
authors.initials: GD
authors.lastname: Qureshi
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000779:Anesthetics, Local / Q000494:pharmacology*; D001565:Benzoates / Q000494:pharmacology; D002850:Chromatography, Gel; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D011343:Procaine / Q000494:pharmacology
chemical_list: D000779:Anesthetics, Local; D001565:Benzoates; C057729:4-ethoxybenzoic acid 2-(isopropylamino)ethyl ester; C000423:2-((2-chloroethyl)methylamino)ethyl-4-ethoxybenzoate; D011343:Procaine; D000244:Adenosine Diphosphate; D004837:Epinephrine