Effects of paweiwan on streptozotocin-induced hyperglycemia in rats.
The ancient Chinese remedy of Paweiwan was used by patients with polyuria, polydipsia, and polyphagia. The present study investigated the hypoglycemic effects of Paweiwan using streptozotocin-induced hyperglycemic rats. The effects on serum glucose in a 4-day course, in a 7-week course, on the standard oral glucose tolerance test, and on the liver glycogen content were studied. In the glucose tolerance test, chlorpropamide and insulin were used as the positive controls and 0.5% CMC (Carboxymethylcellulose) was used as the negative control. We found that Paweiwan decreased the baseline glucose concentration, ameliorated the blood glucose elevation after glucose challenge, and increased liver glycogen content. The results may imply that Paweiwan increases glucose entrance into cells.
Hsieh
M T
MT
Institute of Chinese Pharmaceutical Sciences and Hospital, China Medical College, Taiwan, Republic of China.
Yeh
F T
FT
Chen
H C
HC
Lin
N N
NN
Chen
C F
CF
Wang
T F
TF
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D005951:Glucose Tolerance Test; D006003:Glycogen / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; C057492:paweiwan; D006003:Glycogen