title: [Cerebrovascular ischemic accident and congenital protein C deficiency in children: apropos of a case].
abstract: The authors report the case of a 15-month-old boy with left hemiparesia related to a right sylvian ischemic incident, confirmed by CT scan and carotid angiography. Long-term evolution was favourable with anti-aggregant platelet treatment. A large constitutional protein C deficiency (40%) proved to be the etiology. Protein C is a powerful, physiological, vitamin K-dependent anti-coagulant which neutralizes activated factors V and VIII. Congenital protein C deficiency is responsible for recurrent spontaneous thrombosis affecting the young, mainly in the venous areas, since arterial incidents are less frequent. Protein C assays should be included in the systematic etiologic check-up for thrombotic incidents in children.
authors.affiliation: Service de pédiatrie, hôpital des Enfants, Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Chateil
authors.forename: R
authors.initials: R
authors.lastname: Baronnet
authors.forename: V
authors.initials: V
authors.lastname: Guérin
authors.forename: D
authors.initials: D
authors.lastname: Fontan
authors.forename: J M
authors.initials: JM
authors.lastname: Guillard
mesh_terms: D002545:Brain Ischemia / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D007223:Infant; D011486:Protein C / Q000502:physiology; D020151:Protein C Deficiency
chemical_list: D011486:Protein C
vernacular_title: Accident vasculaire cérébral ischémique de l'enfant et déficit congénital en protéine C: à propos d'une observation.