title: A human genomic sequence highly homologous to the 3'-untranslated region of rat uricase mRNA.
abstract: A human genomic sequence was isolated from a library using a rat uricase cDNA probe. Sequence analysis has shown that it is highly homologous to the 3'-untranslated region of rat uricase mRNA. Total loss of uricase activity in human is, therefore, not due to total loss of the gene. Discovery of high degree of conservation of the non-coding region of the gene would be of great interest as we attempt to learn the process of gene evolution.
authors.affiliation: Department of Biochemistry, Faculty of Pharmaceutical Science, Toho University, Chiba, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Motojima
authors.forename: S
authors.initials: S
authors.lastname: Goto
mesh_terms: D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000032:analysis; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D014503:Urate Oxidase / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D004247:DNA; D014503:Urate Oxidase