title: Psychopharmacological effects of sertraline in normal, healthy volunteers.
abstract: A double-blind, placebo controlled, cross-over study was carried out in 10 normal healthy volunteers to investigate the effects of sertraline 25 mg, 50 mg, 75 mg and 100 mg on aspects of cognitive functioning. Changes with respect to placebo in objective tests of psychomotor function (critical flicker fusion and choice reaction time) showed that sertraline had an alerting effect. The changes were not consistent with subjective reports of drowsiness.
authors.affiliation: Human Psychopharmacology Research Unit, University of Leeds, UK.
authors.forename: I
authors.initials: I
authors.lastname: Hindmarch
authors.forename: J Z
authors.initials: JZ
authors.lastname: Bhatti
mesh_terms: D015057:1-Naphthylamine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005425:Flicker Fusion / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D009281:Naphthalenes / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D020280:Sertraline; D013997:Time Factors
chemical_list: D009281:Naphthalenes; D012702:Serotonin Antagonists; D015057:1-Naphthylamine; D020280:Sertraline