Behavior of Leishmania braziliensis s.l. in golden hamsters: evolution of the infection under different experimental conditions.
Reproducibility of Leishmania braziliensis s.l. metastatic behavior in hamsters was studied for 9 isolates of L.b. panamensis and 2 of L.b. guyanensis with a previous record of metastasis. Also, the influence of corticosteroids and trauma was evaluated. In the corticosteroid-treated group, metastases appeared earlier than in the nontreated group, and localization at the site of trauma was more frequent (4/9) than in the nontreated hamsters (1/5). Nine of the 11 strains (82%) were capable of reproducing metastatic behavior. Studies on dissemination of L. b. panamensis showed that the regional lymph node is invaded as soon as 5 days postinfection, with further nonhematic dissemination to other tissues and organs in less than 4 wk.
Travi
B
B
Centro Internacional de Investigaciones Médicas, Tulane University, Cali, Colombia.
Rey-Ladino
J
J
Saravia
N G
NG
D000818:Animals; D006224:Cricetinae; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D007891:Leishmania / Q000502:physiology*; D007892:Leishmania braziliensis / Q000502:physiology*; D007896:Leishmaniasis / Q000469:parasitology* / Q000473:pathology; D008198:Lymph Nodes / Q000469:parasitology; D008647:Mesocricetus
C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone