Reaction products of a new anti-cancer agent, Pt(IV)(cyclohexyldiamine)Cl4, with guanosine and 9-methylguanine: first crystal structures of Pt(cyclohexyldiamine) complexes with a nucleobase and a nucleoside.
Pt(IV)(dach)Cl4 (dach = cyclohexyldiamine) was reacted with guanosine and 9-methylguanine and their reaction products were analyzed by single-crystal x-ray diffraction. In both cases the resulting complexes, [Pt(dach)(guanosine)2]2+ and [Pt(dach)(9-methylguanine)2]2+ respectively, corresponded to an unanticipated reduction of the octahedral Pt(IV) starting material to a square planar Pt(II) species. The nature of the reducing agent is presently unknown.
Choi
H K
HK
Department of Chemistry, University of Southern California, Los Angeles 90089-0744.
Terzis
A
A
Stevens
R C
RC
Bau
R
R
Haugwitz
R
R
Narayanan
V L
VL
Wolpert-DeFilippes
M
M
D000970:Antineoplastic Agents; D002614:Chelating Agents / Q000032:analysis*; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006151:Guanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008961:Models, Structural; D009944:Organoplatinum Compounds / Q000138:chemical synthesis*; D014961:X-Ray Diffraction
D000970:Antineoplastic Agents; D002614:Chelating Agents; D009944:Organoplatinum Compounds; C057642:cyclohexyldiamine-9-methylguanine platinum IV; C057641:cyclohexyldiamine-guanosine platinum IV; D006151:Guanosine; D006147:Guanine