Effects of feeding regimen on blood glucose levels and plasma concentrations of pancreatic hormones and gut regulatory peptides at 9 months of age: comparison between infants fed with milk formula and infants exclusively breast-fed from birth.
Little is known about the development of gut endocrine responses to food intake in infants after the first postnatal month. To examine this question and to ascertain whether the mode of feeding from birth affects postprandial endocrine changes, blood glucose levels and the plasma concentrations of 11 regulatory peptides were measured at 9 months of age before and after a breast feeding in 13 exclusively breast-fed infants and before and after a formula feeding in 7 infants weaned during the first 3 months of life. In the prefeeding concentrations of these substances, no significant differences were found between the two groups, with the possible exception of the plasma concentration of pancreatic polypeptide (p = 0.06). Postprandially, the responses were significantly smaller in the breast-fed infants, whose plasma concentrations of insulin, gastric inhibitory polypeptide, pancreatic polypeptide, and cholecystokinin were lower than in the formula-fed infants. In addition, the overall level of the insulin-glucagon ratio was lower (p = 0.03) in the breast-fed infants. A difference in the opposite direction was observed for plasma gastrin levels. No significant differences appeared between the groups for blood glucose, or plasma glucagon, vasoactive intestinal polypeptide, motilin, enteroglucagon, secretin, or neurotensin concentrations after feeding. It is concluded that at 9 months of age, the gut regulatory responses to milk feeding are of lower magnitude than during the neonatal period, but even at this age the response patterns still depend on the mode of feeding.
Salmenperä
L
L
Children's Hospital, University of Helsinki, Finland.
Perheentupa
J
J
Siimes
M A
MA
Adrian
T E
TE
Bloom
S R
SR
Aynsley-Green
A
A
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001798:Blood Proteins / Q000032:analysis; D001903:Bottle Feeding; D001942:Breast Feeding; D002784:Cholesterol / Q000097:blood; D005768:Gastrointestinal Hormones / Q000097:blood*; D006801:Humans; D007223:Infant; D007225:Infant Food; D008892:Milk; D009496:Neurotensin / Q000097:blood; D010187:Pancreatic Hormones / Q000097:blood*
D001786:Blood Glucose; D001798:Blood Proteins; D005768:Gastrointestinal Hormones; D010187:Pancreatic Hormones; D009496:Neurotensin; D002784:Cholesterol