title: Platelet aggregation in platelet rich plasma and whole blood in 18 patients affected by idiopathic myelofibrosis.
abstract: Platelet aggregation in whole blood (WB) and in platelet rich plasma (PRP) was studied in 18 consecutive patients affected by idiopathic myelofibrosis (IM). On the basis of WB studies, 22% of patients were classified as normo-aggregating and 22% as hypo-aggregating, while 55% had spontaneous platelet aggregation (SPA). SPA was observed also when platelets from patients were stirred in the presence of normal erythrocytes, while it never occurred when normal platelets were stirred in the presence of red cells from patients. PRP studies revealed that 33% and 66% of patients were, respectively, hypo- and normo-aggregating. The most frequent abnormality in PRP was represented by defective or absent aggregation response to epinephrine.
authors.affiliation: Department of Internal Medicine, University of Pavia, Italy.
authors.forename: C L
authors.initials: CL
authors.lastname: Balduini
authors.forename: G
authors.initials: G
authors.lastname: Bertolino
authors.forename: G
authors.initials: G
authors.lastname: Gamba
authors.forename: G
authors.initials: G
authors.lastname: Barosi
authors.forename: F
authors.initials: F
authors.lastname: Sinigaglia
authors.forename: P
authors.initials: P
authors.lastname: Noris
authors.forename: A
authors.initials: A
authors.lastname: Bisio
authors.forename: E
authors.initials: E
authors.lastname: Ascari
mesh_terms: D000244:Adenosine Diphosphate; D000328:Adult; D000368:Aged; D001769:Blood; D004837:Epinephrine; D004912:Erythrocytes / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma; D010974:Platelet Aggregation; D055728:Primary Myelofibrosis / Q000097:blood* / Q000473:pathology
chemical_list: D000244:Adenosine Diphosphate; D004837:Epinephrine