[Elevated kynurenine concentration in the blood serum of children with epilepsy and bronchial asthma].
A total of 84 children were investigated: 15 with bronchial asthma, 41 with combined seizure and bronchial obstruction syndrome, 14 with epilepsy. The kynurenine blood level was found to correlate with seizures. It was highest in epilepsy (5.27 +/- 0.99 nM/ml) together with the lowest dioxygenase activity (0.53 +/- 0.29 nM/ml) as measured with the tryptophane loading. The data suggest that kynurenine being a major tryptophane metabolite plays a role in pathogenesis of convulsive states.
Ivanova
N A
NA
Ryzhov
I V
IV
Buzdin
V V
VV
Nikitina
Z S
ZS
D000293:Adolescent; D001249:Asthma / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004827:Epilepsy / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D007737:Kynurenine / Q000097:blood*; D008297:Male; D011014:Pneumonia / Q000097:blood; D013053:Spectrophotometry; D014364:Tryptophan
D007737:Kynurenine; D014364:Tryptophan
Povyshenie kontsentratsii kinurenina v syvorotke krovi u deteĭ, bol'nykh épilepsieĭ i bronkhial'noĭ astmoĭ.