DNA adduct formation during continuous feeding of 2-acetylaminofluorene at multiple concentrations.
A linear relationship was observed between the administered dose and DNA adduct levels in the livers and bladders of BALB/c mice fed the carcinogen, 2-acetylaminofluorene (2-AAF), continuously for one month. A similar linear correlation was found between the probit of the liver tumour incidence and the log of the liver DNA adduct levels; however, because there is a no-observable-effect level for bladder tumour induction, the relationship between the probit of the bladder tumour incidence and bladder DNA adduct levels was not linear. These data suggest that the relationship between DNA adduct formation and tumour incidence may be tissue specific.
Beland
F A
FA
National Center for Toxicological Research, Jefferson, AR.
Fullerton
N F
NF
Kinouchi
T
T
Poirier
M C
MC
D015073:2-Acetylaminofluorene / Q000378:metabolism*; D000818:Animals; D004247:DNA / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D051379:Mice; D008807:Mice, Inbred BALB C; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
D004247:DNA; D015073:2-Acetylaminofluorene