title: [Treatment of experimental trypanosomiasis of sheep caused by Trypanosoma brucei brucei: efficacy of Ro 15-0216 (a 2-nitroimidazole derivative)].
abstract: An experiment was carried out on treatment of Trypanosoma brucei brucei experimentally infected sheep with central nervous system involvement with a 2-nitroimidazole derivative: Ro 15-0216 (Hoffmann La Roche & Co Ltd, Basel, Switzerland). After a single intramuscularly or intravenously administration (25 or 50 mg/kg) of this compound in healthy sheep, levels of more than 1 microgram/ml corresponding to trypanocidal concentrations are detected in both blood and cerebrospinal fluid. However, because of short half life, two or three injections a day appeared to be necessary. Six infected sheep were treated by daily intravenous injection for six days: three animals with 25 mg/kg/d and three others with 50 mg/kg/d. Animals which relapsed received 50 mg/kg/d divided in three intravenous injections a day for six days. After a year of observation, all the animals were considered clinically and biologically cured.
authors.affiliation: Service de Parasitologie-Mycologie, C.H.U. Dupuytren, Limoges.
authors.forename: B
authors.initials: B
authors.lastname: Bouteille
authors.forename: M L
authors.initials: ML
authors.lastname: Darde
authors.forename: M
authors.initials: M
authors.lastname: Pestre-Alexandre
authors.forename: M
authors.initials: M
authors.lastname: Dumas
authors.forename: J C
authors.initials: JC
authors.lastname: Breton
authors.forename: J A
authors.initials: JA
authors.lastname: Nicolas
authors.forename: G
authors.initials: G
authors.lastname: Catanzano
authors.forename: M
authors.initials: M
authors.lastname: Munoz
mesh_terms: D000083:Acetanilides / Q000627:therapeutic use*; D000818:Animals; D009593:Nitroimidazoles / Q000627:therapeutic use*; D012756:Sheep; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014346:Trypanosoma brucei brucei; D014353:Trypanosomiasis, African / Q000188:drug therapy*
chemical_list: D000083:Acetanilides; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C054646:Ro 15-0216
vernacular_title: Traitement de la trypanosomiase expérimentale du mouton à Trypanosoma brucei brucei: efficacité du Ro 15-0216 (dérivé 2-nitroimidazolé).