Suppression of newborn natural killer cell activity by prostaglandin E2.
The effect of prostaglandin E2 on natural killer cell activity of cord blood was examined. Natural killer cell activity, determined by chromium 51 release, was significantly reduced after prostaglandin E2 (1 microgram/ml) treatment. Prostaglandin E2 has been found to enhance the cellular spread of herpesvirus. Thus prostaglandins may enhance viral infections indirectly by suppressing natural killer cell activity.
Milch
P O
PO
Department of Obstetrics and Gynecology, State University of New York, Stony Brook 11794.
Salvatore
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W
Luft
B
B
Baker
D A
DA
D000212:Acyclovir / Q000494:pharmacology; D002460:Cell Line; D002860:Chromium Radioisotopes; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D015232:Dinoprostone / Q000494:pharmacology*; D005312:Fetal Blood / Q000276:immunology*; D006564:Herpesviridae / Q000276:immunology; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology; D066298:In Vitro Techniques; D007231:Infant, Newborn; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D011374:Progesterone / Q000494:pharmacology
D002860:Chromium Radioisotopes; D011374:Progesterone; D015232:Dinoprostone; D007052:Ibuprofen; D000212:Acyclovir