Heterotransplantation of malignant human gliomas in neonatal rats.
Three human glioma cell lines (TE-671 medulloblastoma, U-87 MG glioblastoma, and U-373 MG glioblastoma) were transplanted to the quadrigeminal cistern of the brain in 37 newborn Sprague-Dawley rats and to the subcutaneous space in 30 of their siblings. Two of the three gliomas (the TE-671 medulloblastoma and the U-87 MG glioblastoma) grew both intracranially and subcutaneously. The U-373 MG glioblastoma did not grow in either site. The resulting tumors expressed unique morphological features characteristic of their tissue of origin. The newborn rat represents a model for the heterologous transplantation of human gliomas, providing a biological window for the study of these lesions.
Tamargo
R J
RJ
Department of Neurological Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Epstein
J I
JI
Brem
H
H
D000818:Animals; D000831:Animals, Newborn; D005910:Glioma / Q000473:pathology*; D006801:Humans; D008527:Medulloblastoma / Q000473:pathology*; D008866:Microsurgery / Q000379:methods; D009368:Neoplasm Transplantation / Q000379:methods*; D051381:Rats; D011919:Rats, Inbred Strains; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured