Physiological antioxidants and antioxidative enzymes in vitamin E-deficient rats.
The effects of feeding vitamin E-deficient diets to rats for one year were investigated to analyse the relationship of the vitamin with other antioxidants and some antioxidative enzymes. Long-term vitamin E deficiency lowered the levels of antioxidants like vitamin E, ascorbic acid and glutathione (GSH) in all tissues analysed and thus increasing the extent of tissue peroxidisability. Vitamin E deficiency had also influenced the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase, the enzymes that are involved in detoxification mechanisms of products arising from free radical metabolism.
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Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
Darad
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D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D001835:Body Weight; D001921:Brain / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism*; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D010544:Peroxidases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism*; D014810:Vitamin E / Q000378:metabolism / Q000502:physiology*; D014811:Vitamin E Deficiency / Q000201:enzymology / Q000378:metabolism*
D014810:Vitamin E; D010544:Peroxidases; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione; D001205:Ascorbic Acid