title: Specific binding sites of muroctasin on murine macrophages.
abstract: The specific binding sites for N2-[N-acetylmuramoyl)-L-alanyl-D-isoglutaminyl]-N6-stearoyl-L-lysine (MDP-Lys(L18), muroctasin), a synthetic muramyl dipeptide analog, on murine macrophages were investigated using [3H]-MDP-Lys(L18). The specific binding sites were found to be located on macrophage membrane and not to cross-react with MDP. It was also found that MDP-Lys(L18) was not metabolized by macrophages.
authors.affiliation: Research Institute, Daiichi Seiyaku Co., Ltd., Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Akasaki
authors.forename: H
authors.initials: H
authors.lastname: Masayasu
authors.forename: W
authors.initials: W
authors.lastname: Tsukada
authors.forename: T
authors.initials: T
authors.lastname: Takegoshi
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000378:metabolism; D000276:Adjuvants, Immunologic / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D002855:Chromatography, Thin Layer; D003429:Cross Reactions; D005260:Female; D008264:Macrophages / Q000378:metabolism*; D051379:Mice
chemical_list: D000276:Adjuvants, Immunologic; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C036866:romurtide