title: Gene for parathyroid hormone-like peptide is on rat chromosome 2.
abstract: Parathyroid hormone-like peptide (PLP) is thought to be a mediator of hypercalcemia in both human and rodent malignancies. A rat PLP cDNA was used as a hybridization probe in Southern blot analysis of DNAs isolated from a panel of rat-mouse somatic cell hybrids. The single-copy gene for PLP was assigned to rat chromosome 2, whereas the rat parathyroid hormone (PTH) gene has previously been assigned to rat chromosome 1. Consequently, despite significant amino-terminal homology between PLP and PTH the genes encoding these peptides in the rat as well as human species have discrete chromosomal localizations.
authors.affiliation: Department of Medicine, McGill University, Montreal, PQ, Canada.
authors.forename: G N
authors.initials: GN
authors.lastname: Hendy
authors.forename: A Y
authors.initials: AY
authors.lastname: Sakaguchi
authors.forename: T
authors.initials: T
authors.lastname: Yasuda
authors.forename: D K
authors.initials: DK
authors.lastname: Weber
authors.forename: L M
authors.initials: LM
authors.lastname: Wang
authors.forename: M C
authors.initials: MC
authors.lastname: Yoshida
authors.forename: D
authors.initials: D
authors.lastname: Banville
authors.forename: D
authors.initials: D
authors.lastname: Goltzman
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D009363:Neoplasm Proteins / Q000235:genetics*; D044162:Parathyroid Hormone-Related Protein; D051381:Rats / Q000235:genetics*; D013045:Species Specificity
chemical_list: D009363:Neoplasm Proteins; D044162:Parathyroid Hormone-Related Protein