The pharmacokinetics of theophylline and enprofylline in patients with liver cirrhosis and in patients with chronic renal disease.
We have studied the pharmacokinetics of theophylline and enprofylline in patients with liver cirrhosis, patients with chronic renal failure, and healthy subjects, and have assessed the predictive value of routine tests of liver function and renal function (creatinine clearance) for theophylline and enprofylline total body clearances. Theophylline clearance was significantly decreased in the patients with liver cirrhosis compared with both the patients with renal failure and the healthy subjects (the mean values in the three groups were 24, 47, and 46 ml.h-1.kg-1 respectively. Enprofylline clearance was significantly decreased in the patients with chronic renal failure, compared with both the patients with liver cirrhosis and the healthy subjects (the values in the three groups were 64, 250, and 289 ml.h-1.kg-1 respectively. There was a strong correlation between creatinine clearance and enprofylline clearance, while there was only a poor correlation between the liver function tests and theophylline clearance. It appears that in various clinical situations enprofylline elimination can be predicted more precisely than theophylline elimination, which may make the drug safer in clinical practice.
Kraan
J
J
Department of Pulmonology, State University Groningen, Sweden.
Jonkman
J H
JH
Koëter
G H
GH
Gips
C H
CH
de Jong
P E
PE
van der Mark
T W
TW
Ekman
I
I
de Zeeuw
R A
RA
D000328:Adult; D000368:Aged; D001993:Bronchodilator Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D007677:Kidney Function Tests; D008103:Liver Cirrhosis / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D014970:Xanthines / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D001993:Bronchodilator Agents; D014970:Xanthines; D013806:Theophylline; C034347:enprofylline