Growth and growth hormone therapy of children treated for leukaemia.
A total of 37 children (24 male, 13 female) who had been treated for leukaemia with chemotherapy and 24 Gy cranial irradiation, and who were disease free for at least 18 months, were commenced on somatrem at a mean of 7.6 years (range, 4.8-12.1 years) after leukaemia diagnosis because of growth rate below the 25th centile for bone age. Peak GH response to provocation (exercise, arginine, insulin hypoglycaemia) was less than 20 milliunits/litre in 27 children (deficient group) and 20 milliunits/litre or more in 10 children (non-deficient group). The mean height SD decrease from diagnosis of leukaemia to commencement of somatrem was 1.98, 86% of the children decreasing by more than 1 SD. Those who were tall for age at leukaemia diagnosis and females were more severely affected. Mean (+/- SD) height velocity increased on somatrem from 2.7 +/- 1.1 to 6.6 +/- 2.2 cm/year during the first 6 months (n = 25), and to 6.0 +/- 1.7 cm/year during the first 12 months (n = 19). No difference in growth response was seen between the sexes or between the deficient and non-deficient groups. Catch-up growth occurred for the first 6 months only. It is concluded that children with a low growth rate after treatment of leukaemia should be considered for GH therapy irrespective of the results of GH provocative tests.
Cowell
C T
CT
Institute of Endocrinology, Children's Hospital, Camperdown, Sydney, Australia.
Quigley
C A
CA
Moore
B
B
Kirk
J A
JA
Bergin
M
M
Jimenez
M
M
Stevens
M M
MM
Howard
N J
NJ
Menser
M A
MA
Silink
M
M
D000293:Adolescent; D001827:Body Height / Q000187:drug effects; D001921:Brain / Q000528:radiation effects; D002648:Child; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology; D013006:Growth Hormone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D019382:Human Growth Hormone; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000532:radiotherapy*
D019382:Human Growth Hormone; D013006:Growth Hormone