[Effect of dimephosphon on the adenine nucleotide system].
The effect of a single injection of dimephosphon (1 mM/kg) on adenine nucleotide system in the liver of healthy and chlorophos-poisoned (a mean lethal dose) rats was studied. It was shown that in healthy rats dimephosphon decreased the levels of all components of adenylate system without changing the energy charge of adenylates. The treatment of the poisoned animals with dimephosphon normalized the parameters of energy metabolism disturbed by chlorophos intoxication.
Ziganshin
A U
AU
Studentsova
I A
IA
Zaikonnikova
I V
IV
D000208:Acute Disease; D000227:Adenine Nucleotides / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D000931:Antidotes / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D008099:Liver / Q000032:analysis / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013997:Time Factors; D014236:Trichlorfon / Q000506:poisoning
D000227:Adenine Nucleotides; D000931:Antidotes; D000975:Antioxidants; D009943:Organophosphorus Compounds; C049638:dimephosphon; D014236:Trichlorfon
Vliianie dimefosfona na sistemu adenilovykh nukleotidov.