Virally induced modulation of murine IgG antibody subclasses.
The isotypic distribution of murine IgG was examined after infection with several viruses. The results indicate that when a hypergammaglobulinemia was induced by the infection, it was restricted to the IgG2a and, to a lesser extent, to the IgG2b subclasses. In addition, when mice were infected with some viruses concomitantly with the immunization with a soluble protein antigen, a modification in the isotypic distribution of antiprotein antibodies was observed, with a preferential production of IgG2a. These observations indicate that viral infections can actively influence the switch of Igs and selectively stimulate the production of the IgG2a subclass.
Coutelier
J P
JP
Unit of Experimental Medicine, Université Catholique de Louvain, Bruxelles, Belgium.
van der Logt
J T
JT
Heessen
F W
FW
Vink
A
A
van Snick
J
J
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D007114:Immunization; D007074:Immunoglobulin G / Q000145:classification*; D051379:Mice; D014764:Viral Proteins / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D014764:Viral Proteins