Injurious effect of eosinophil extract on the human nasal mucosa.
Eosinophils are frequently associated with the manifestation of nasal allergy in the nasal mucosa and nasal secretion. The role of eosinophils in hypersensitivity diseases, however, is still obscure, whether it protects or damages tissues and activates mast cells. The effects of two kinds of human eosinophil extract (biological and physical extracts) on human nasal mucosa by applying them in nasal provocation test and cilia beating test, and also in tracheal ring incubation and skin test in the guinea-pig were measured. The results of the study suggest that eosinophil major protein and other protein components may produce damage to the function of human nasal mucosa and tracheal mucosa of the guinea-pig.
Liu
C M
CM
Dept. of Otorhinolaryngology, National Taiwan University Hospital, Taipei.
Okuda
M
M
D000818:Animals; D001798:Blood Proteins / Q000633:toxicity; D002457:Cell Extracts / Q000032:analysis / Q000633:toxicity*; D002923:Cilia / Q000187:drug effects; D004586:Electrophoresis / Q000379:methods; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000502:physiology*; D006168:Guinea Pigs; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D009297:Nasal Mucosa / Q000187:drug effects* / Q000276:immunology; D009299:Nasal Provocation Tests; D012130:Respiratory Hypersensitivity / Q000276:immunology; D012260:Ribonucleases; D014020:Tissue Extracts / Q000633:toxicity*
D001798:Blood Proteins; D002457:Cell Extracts; D047091:Eosinophil Granule Proteins; D014020:Tissue Extracts; D007770:L-Lactate Dehydrogenase; D012260:Ribonucleases