Mutations in the hemagglutinin gene associated with influenza virus resistance to norakin.
The nucleotide sequences of the hemagglutinin genes of four norakin-resistant mutants of Influenza A/FPV/Weybridge were determined and compared to the wild-type hemagglutinin. All mutants show one or two amino acid substitutions which are discussed to destabilise the pH 7 conformation of hemagglutinin.
Prösch
S
S
Institute of Medical Virology, Humboldt University, Berlin, German Democratic Republic.
Heider
H
H
Schroeder
C
C
Krüger
D H
DH
D000595:Amino Acid Sequence; D004352:Drug Resistance, Microbial; D005814:Genes, Viral; D006389:Hemagglutinins, Viral / Q000235:genetics*; D009980:Influenza A virus / Q000187:drug effects / Q000235:genetics*; D010880:Piperidines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D006389:Hemagglutinins, Viral; D010880:Piperidines; C046667:triperiden