title: [Mathematical modeling of the processes of DNA synthesis in irradiated cells and cell populations. Modeling of the initiation and elongation of DNA chains in irradiated mammalian cells].
abstract: Dose-dependence of DNA synthesis inhibition in cells of HeLa suspension culture, bone marrow and thymus of mice was investigated. A contribution of inhibition of replicon synthesis and DNA chain elongation to the total effect of DNA synthesis inhibition by gamma-radiation was estimated by mathematical simulation. The method is proposed for evaluation of Di that characterizes cell radiosensitivity. Radiosensitivity of HeLa cells after preirradiation or exposure to 5-fluorodeoxyuridine was assessed.
authors.forename: B I
authors.initials: BI
authors.lastname: Synzynys
authors.forename: E V
authors.initials: EV
authors.lastname: Shapovalova
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D003037:Cobalt Radioisotopes; D003198:Computer Simulation; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects*; D005720:Gamma Rays; D006367:HeLa Cells; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D013950:Thymus Gland / Q000166:cytology
chemical_list: D003037:Cobalt Radioisotopes; D004247:DNA
vernacular_title: Matematicheskoe modelirovanie protsessov sinteza DNK v obluchennykh kletkakh i kletochnykh populiatsiiakh. Modelirovanie initsiatsii i élongatsii tsepeĭ DNK v obluchennykh kletkakh mlekopitaiushchikh.