[Phenotypic correction of the immune response by L-tyrosine in mice reacting oppositely to sheep erythrocytes].
The possibility of transversion of low-reacting mice into high-reacting ones evaluated by the application of the natural immunostimulators. L-tyrosine and thymic polypeptides (taktivin) were compared by their ability for the phenotypical correction of the immune response of the oppositely reacting mice. It was established that under the application of L-tyrosine to oppositely reacting mice the phenotypical correction of the immune response is possible. The dramatic increase in AFC and the AFC-SI secreting IgM is observed in the mice, low-reacting to SRBC in comparison with the high-reacting lines.
Lebedev
V V
VV
Titov
M I
MI
Maksimova
G F
GF
Portnova
A P
AP
Molokoedov
A S
AS
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D004912:Erythrocytes / Q000276:immunology*; D007114:Immunization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010455:Peptides / Q000494:pharmacology; D010641:Phenotype; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013949:Thymus Extracts / Q000494:pharmacology; D014443:Tyrosine / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; D014443:Tyrosine; C036191:T-activin
Fenotipicheskaia korrektsiia immunnogo otveta L-tirozinom u mysheĭ, oppozitno reagiruiushchikh na éritrotsity barana.