[Intraindividual comparison of the elimination kinetics of Lipofundin S and Intralipid in consecutive lipid tolerance tests].
Two intravenous fat tolerance tests (IVFTT) were performed in 16 healthy volunteers and 8 patients suffering from hypertriglyceridemia (HTG). We compared Lipofundin S (Braun, Melsungen) with Intralipid (Kabi Vitrum, Stockholm), using both 10- and 20% concentrations. Time intervals between the tests were 1 h for the volunteers and 2 h for the patients with HTG, respectively. Fractional elimination rates were obtained from light scattering intensity of serum samples. They were significantly higher for Lipofundin S (9.61%/min for healthy men and 12.48%/min for healthy women) compared to Intralipid (7.09%/min for healthy men and 9.41%/min for healthy women). This difference occurred independently of (1) serum triglyceride concentrations and sex of the volunteers, (2) concentrations of lipid emulsions (10 vs. 20%), and (3) the test sequence (Lipofundin S or Intralipid first). This means that the elimination kinetics during an IVFTT are not influenced by a foregoing test. Similar features of both emulsion types were: (1) Faster elimination in women compared to men, and in healthy volunteers compared to HTG patients; (2) inverse correlation between fractional elimination rates and serum triglyceride concentrations. Fractional elimination rates of Lipofundin S and Intralipid were closely interrelated. Obviously there exists an intra-individually characteristic elimination capacity for exogenous triglycerides.
Leonhardt
W
W
Klinik für Innere Medizin der Medizinischen Akademie Carl Gustav Carus, Dresden.
Julius
U
U
D000328:Adult; D004338:Drug Combinations / Q000493:pharmacokinetics; D005217:Fat Emulsions, Intravenous / Q000493:pharmacokinetics*; D005260:Female; D005990:Glycerol / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D010743:Phospholipids / Q000493:pharmacokinetics*; D010938:Plant Oils / Q000493:pharmacokinetics*; D012016:Reference Values; D013024:Soybean Oil / Q000493:pharmacokinetics*
D004338:Drug Combinations; D005217:Fat Emulsions, Intravenous; D010743:Phospholipids; D010938:Plant Oils; C046535:Lipofundin S; D013024:Soybean Oil; D005990:Glycerol
Intraindividueller Vergleich der Eliminationskinetik von Lipofundin S und Intralipid in aufeinanderfolgenden Fettoleranztests.