title: Extent and pharmacokinetic mechanisms of oral atenolol-verapamil interaction in man.
abstract: Chronic coadministration of oral verapamil with oral atenolol resulted in a variable increase in atenolol steady-state plasma concentrations in a group of 10 patients on chronic maintenance therapy. Individual subjects showed changes in area under the plasma atenolol concentration-time curve (AUC) of more than 100%, however group comparisons did not achieve statistical significance unless normalized for verapamil dose. Renal clearance of atenolol was shown to be decreased by more than 25% in 2 subjects studied using intravenous dosing of atenolol. This interaction is likely to contribute to the documented clinical intolerance of combinations of atenolol and verapamil.
authors.affiliation: Department of Clinical Pharmacology, Alfred Hospital, Melbourne, Victoria, Australia.
authors.forename: A C
authors.initials: AC
authors.lastname: Keech
authors.forename: R W
authors.initials: RW
authors.lastname: Harper
authors.forename: P M
authors.initials: PM
authors.lastname: Harrison
authors.forename: A
authors.initials: A
authors.lastname: Pitt
authors.forename: A J
authors.initials: AJ
authors.lastname: McLean
mesh_terms: D000284:Administration, Oral; D000368:Aged; D001262:Atenolol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D001262:Atenolol; D014700:Verapamil