Depressed convulsions by diazepam and its effects on brain monoamines and amino acids in E1 mice.
The effect of diazepam on inbred mutant E1 mice, which develop convulsive seizures after repeated sessions of being tossed up, was examined. Acute administration of diazepam (32 mg/kg, i.p.) completely inhibited the convulsions. At that time, the dopamine level was increased in the cortex and hippocampus, and the norepinephrine level in the cerebellum was decreased. 5-Hydroxytryptamine levels were not changed. As for amino acids, the glutamine level increased and the levels of GABA, glutamic acid, aspartic acid, alanine and other amino acids were not changed.
Hiramatsu
M
M
Department of Neurochemistry, Okayama University Medical School, Japan.
Kabuto
H
H
Kwon
M J
MJ
Ishii
A
A
Mori
A
A
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D003975:Diazepam / Q000627:therapeutic use*; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000378:metabolism*; D012640:Seizures / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism
D000596:Amino Acids; D000927:Anticonvulsants; D015306:Biogenic Monoamines; D003975:Diazepam