title: Discriminative stimulus effects of intravenous nicotine in squirrel monkeys.
abstract: Three squirrel monkeys were trained to emit one response after IV administration of nicotine (0.1 or 0.18 mg/kg depending on the subject) and a different response after IV administration of saline. Subjects emitted nicotine-appropriate responses with substitutions of higher doses, but only emitted saline-appropriate responses after substitutions of lower doses. Discrimination performance was then maintained at 0.1 mg/kg of nicotine in all subjects. Neither morphine nor cocaine substituted for the effects of nicotine in any subjects across a range of doses up to those that suppressed responding. Ethyl-beta-carboline-3-carboxylate, an inverse agonist at the benzodiazepine receptor, substituted or partially substituted for nicotine in both subjects in which it was studied.
authors.affiliation: Preclinical Pharmacology Branch, NIDA Addiction Research Center, Baltimore, MD 21224.
authors.forename: K
authors.initials: K
authors.lastname: Takada
authors.forename: T J
authors.initials: TJ
authors.lastname: Hagen
authors.forename: J M
authors.initials: JM
authors.lastname: Cook
authors.forename: S R
authors.initials: SR
authors.lastname: Goldberg
authors.forename: J L
authors.initials: JL
authors.lastname: Katz
mesh_terms: D000818:Animals; D003216:Conditioning, Operant; D004193:Discrimination Learning; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D012453:Saimiri
chemical_list: D009538:Nicotine