[The effect of vitamin K deficiency in rats on various enzyme systems participating in energy metabolism].
In alimentary deficiency of vitamin K in rats, accompanied by an increase in the prothrombin time by 30%, activity of kidney creatine kinase and of blood serum alkaline phosphatase was unaltered, while the activity of alkaline phosphatase in small intestinal mucose was decreased by 20% and that of creatine kinase from skeletal muscles--by 10%. In vitamin K-deprived animals the rate of coupling between respiration and mitochondrial phosphorylation was decreased, which might be due to alteration in the NADH-dehydrogenase complex. Menadion reductase activity and cyanide-resistant respiration of mitochondria were unaltered in presence of menadion. Palmitic acid effectively activated of mitochondrial respiration in vitamin K-deprived animals (contrary to the control rats). This effect appears to occur as a result of structural alterations in mitochondria depending on vitamin K level in the organelles.
Kolesova
G M
GM
Sokol'nikov
A A
AA
Kodentsova
V M
VM
Klimova
O A
OA
Sergeev
I N
IN
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism; D004734:Energy Metabolism; D007413:Intestinal Mucosa / Q000201:enzymology; D007668:Kidney / Q000201:enzymology; D007700:Kinetics; D008930:Mitochondria, Liver / Q000378:metabolism; D009132:Muscles / Q000201:enzymology; D010101:Oxygen Consumption / Q000187:drug effects; D010169:Palmitic Acids / Q000494:pharmacology; D011808:Quinone Reductases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014812:Vitamin K / Q000378:metabolism; D014813:Vitamin K Deficiency / Q000201:enzymology* / Q000378:metabolism
D010169:Palmitic Acids; D014812:Vitamin K; D011808:Quinone Reductases; D003402:Creatine Kinase; D000469:Alkaline Phosphatase
Vliianie nedostatochnosti vitamina K u krys na nekotorye fermentnye sistemy, uchastvuiushchie v énergoobespechenii.