Discriminative stimulus effects of intravenous nicotine in squirrel monkeys.
Three squirrel monkeys were trained to emit one response after IV administration of nicotine (0.1 or 0.18 mg/kg depending on the subject) and a different response after IV administration of saline. Subjects emitted nicotine-appropriate responses with substitutions of higher doses, but only emitted saline-appropriate responses after substitutions of lower doses. Discrimination performance was then maintained at 0.1 mg/kg of nicotine in all subjects. Neither morphine nor cocaine substituted for the effects of nicotine in any subjects across a range of doses up to those that suppressed responding. Ethyl-beta-carboline-3-carboxylate, an inverse agonist at the benzodiazepine receptor, substituted or partially substituted for nicotine in both subjects in which it was studied.
Takada
K
K
Preclinical Pharmacology Branch, NIDA Addiction Research Center, Baltimore, MD 21224.
Hagen
T J
TJ
Cook
J M
JM
Goldberg
S R
SR
Katz
J L
JL
D000818:Animals; D003216:Conditioning, Operant; D004193:Discrimination Learning; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D012453:Saimiri
D009538:Nicotine