[The effect of calcium pantothenate and homopantothenate on [14C]-GABA absorption by slices of rat cerebral cortex].
Calcium D-pantothenate (Ca D-P) and calcium D-homopantothenate (Ca D-HP) (pantogam) exhibiting antagonism in a number tests of pharmacological screening were shown to inhibit the absorption of [14C]-GABA (0.2 microM) by the rat brain cortex slices (3 mm) incubated in calcium-free medium. The effect of Ca D-HP manifests at its low concentrations (10(-6) M) and that of Ca D-P at high concentrations (10(-6) M). The data obtained are discussed in relation to the possible influence of the anion and cation components of the studied compounds.
Reĭtarova
T E
TE
Rozanov
V A
VA
Kovler
M A
MA
Kopelevich
V M
VM
Totskiĭ
V N
VN
D000042:Absorption; D000818:Animals; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D018756:GABA Antagonists; D008297:Male; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology
D002250:Carbon Radioisotopes; D018756:GABA Antagonists; C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid
Vliianie pantotenata i gomopantotenata kal'tsiia na pogloshchenie [14C]-GAMK srezami kory golovnogo mozga krys.