Increased urinary excretion of glycosaminoglycans in insulin-dependent diabetic patients with limited joint mobility.
Urinary excretion of glycosaminoglycans (GAG) was measured in 24-h specimens collected from 27 insulin-dependent male diabetic patients and 22 healthy males of similar ages. Excretion relative to creatinine was increased by 35% in the diabetic group as a whole (p less than 0.02). Twelve patients with limited joint mobility (cheiroarthropathy) formed a subgroup with high excretion (69% above controls), those without limited joint mobility being similar to controls. There was no correlation of retinopathy with GAG excretion.
Priestley
G C
GC
University Department of Dermatology, Royal Infirmary, Edinburgh, Scotland.
Collier
A
A
Matthews
D M
DM
Clarke
B F
BF
D000328:Adult; D003404:Creatinine / Q000652:urine; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000652:urine*; D003930:Diabetic Retinopathy / Q000652:urine; D006025:Glycosaminoglycans / Q000652:urine*; D006801:Humans; D007592:Joint Diseases / Q000150:complications / Q000652:urine*; D008297:Male
D006025:Glycosaminoglycans; D003404:Creatinine