[Intrarectal clonazepam in children. Plasma and CSF levels].
Eleven children with seizures were treated with clonazepam by rectal route. Thirty minutes after the administration, the plasma (8 to 28 ng/ml) and CSF (0.9 to 2.26 ng/ml) levels were satisfactory and correlated with a good clinical result. Since the tolerance of the drug was excellent, clonazepam appears to be as useful as diazepam in the management of childhood seizures.
Netter
J C
JC
Service de pédiatrie, néonatologie, Centre Hospitalier de Tarbes, France.
Fornaris
M
M
Bildstein
G
G
Chateauneuf
R
R
Cano
J P
JP
Petrus
M
M
D000285:Administration, Rectal; D002648:Child; D002675:Child, Preschool; D002998:Clonazepam / Q000008:administration & dosage* / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012640:Seizures / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy*
D002998:Clonazepam
Clonazépam intrarectal chez l'enfant. Taux plasmatique et dans le LCR.