title: Tumour induction in mice following exposure to aristolochic acid.
abstract: After treatment for 3 weeks with aristolochic acid (AA) in daily doses of 5.0 mg/kg mice were kept under observation for approximately 1 year. During this period papillomatous changes occurred in the forestomach. At a later stage, squamous cell carcinomas were observed in all the animals. In one case, an adenocarcinoma was found in the glandular stomach. In addition, malignant lymphomas were found, as well as adenomas of the kidneys, carcinomas of the lungs, and haemangiomas of the uteri.
authors.affiliation: Department of Toxicology and Experimental Pathology Dr. Madaus GmbH & Co., Köln, Federal Republic of Germany.
authors.forename: U
authors.initials: U
authors.lastname: Mengs
mesh_terms: D000818:Animals; D034341:Aristolochic Acids; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010616:Phenanthrenes / Q000633:toxicity*; D051381:Rats
chemical_list: D034341:Aristolochic Acids; D010616:Phenanthrenes; C000228:aristolochic acid I