title: Constant oxygen insufflation (COI) in a ventilatory failure model.
abstract: We examined the use of a constant insufflation of oxygen into the lungs to assist ventilation in a ventilatory failure model. The model consisted of 12 anesthetized dogs (17 to 32 kg) that were partially paralyzed using intermittent low doses of muscle relaxant; this produced a steady-state mean PaCO2 of 90 +/- 15.8 mm Hg (+/- SD). A catheter (1.5 mm ID) was inserted into each lung to the most distal position possible and withdrawn 1 to 2 cm. The effects of a constant insufflation of oxygen at rates of 5, 10, or 20 L/min were studied at this position (mean distance from the carina = 9 +/- 2 cm); at the carina; and using a single catheter located 2 cm above the carina. The changes in PaCO2 and minute ventilation (VE) due to the insufflation were calculated from the mean steady-state control values. Using the data for all catheter positions and flow rates, the insufflation was associated with a mean decrease in PaCO2 of 31 (+/- 7.6) mm Hg associated with a mean decrease in VE of 48 (+/- 12.9)%. The flow of 20 L/min caused a significantly greater drop in PaCO2 than the flow of 5 L/min (p = 0.02). This technique may prove beneficial for patients with various forms of ventilatory failure that are difficult to treat by conventional means.
authors.affiliation: Department of Medicine, Mount Sinai Hospital Research Institute, West Park Hospital, Toronto, Ontario, Canada.
authors.forename: S E
authors.initials: SE
authors.lastname: Long
authors.forename: A S
authors.initials: AS
authors.lastname: Menon
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: R S
authors.initials: RS
authors.lastname: Goldstein
authors.forename: A S
authors.initials: AS
authors.lastname: Slutsky
mesh_terms: D000208:Acute Disease; D000818:Animals; D001784:Blood Gas Analysis; D002404:Catheterization / Q000379:methods; D004195:Disease Models, Animal; D004285:Dogs; D008168:Lung / Q000503:physiopathology; D010102:Oxygen Inhalation Therapy / Q000295:instrumentation / Q000379:methods*; D010313:Partial Pressure; D012131:Respiratory Insufficiency / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D014403:Tubocurarine / Q000031:analogs & derivatives
chemical_list: C032943:metocurine; D014403:Tubocurarine