The involvement of serotonergic and dopaminergic systems in hypothermia induced in mice by intracerebroventricular injection of serotonin.
The hypothermia elicited in mice by intracerebroventricular injection (i.c.v.) of serotonin (5-HT) was studied. The 5-HT-induced hypothermia was attenuated by methysergide and pindolol, although ketanserin and p-chlorophenylalanine were without effect. These results suggest that 5-HT-induced hypothermia is produced by the direct activation of the 5-HT1 receptor. In addition, haloperidol, pimozide and alpha-MT inhibited 5-HT-induced hypothermia, which indicates that the dopaminergic systems are also involved in 5-HT-induced hypothermia in mice.
Yamada
J
J
Department of Pharmacology, Kobe Women's College of Pharmacy, Japan.
Sugimoto
Y
Y
Wakita
H
H
Horisaka
K
K
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D004298:Dopamine / Q000502:physiology; D007035:Hypothermia / Q000209:etiology* / Q000503:physiopathology; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011954:Receptors, Dopamine / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology*; D012701:Serotonin / Q000008:administration & dosage
D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012701:Serotonin; D004298:Dopamine