Effect of apamin on local rates of glucose utilization in the brain and the spinal cord in rats.
The effects of apamin on local rates of glucose utilization in the brain and spinal cord were studied employing the quantitative autoradiographic deoxyglucose method. Forty-five to 60 min after administration of apamin the animals lost exploratory behavior, remaining completely immobile, with the 4 limbs overextended, unresponsive to auditory stimuli. Out of 30 neural structures examined, glucose utilization was significantly decreased in the cochlear n., superior olivary n., lateral lemniscus, inferior colliculus, medial geniculate body, fastigial n., globus pallidus, caudate-putamen, n. accumbens and the lumbar ventral horn of the spinal cord. These results show that apamin specifically affects the functional activity of the auditory and motor structures.
Cohen
S
S
Division of Neurosurgery, University of Texas Medical Branch, Galveston 77550.
Kadekaro
M
M
Terrell
M L
ML
Gary
H
H
Eisenberg
H M
HM
D000818:Animals; D001030:Apamin / Q000494:pharmacology*; D001345:Autoradiography; D001514:Bee Venoms / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D007091:Image Processing, Computer-Assisted; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism*
D001514:Bee Venoms; D003837:Deoxy Sugars; D009498:Neurotoxins; D001030:Apamin; D003847:Deoxyglucose