[Effect of acute vitamin B1 deficiency caused by oxythiamine on protein biosynthesis in the spleen during immunogenesis].
Distinct increase in incorporation of 14C-protein hydrolysate of chlorella (5 microCi per an animal of 150 g body mass) into proteins of rat spleen was observed within 4 days after a single or repeated immunization of rats (180-200 g of body mass) with human blood serum gamma-immunoglobulin at a dose of 30-40 mg per 1 kg of animal mass. Under conditions of acute B1-avitaminosis caused by a single administration of hydroxythiamine at a high dose of 400 mg/kg incorporation of the label into spleen proteins of the immunized rats was decreased within 72 hrs. Thus, acute hydroxythiamine-produced B1-avitaminosis inhibited induction of protein biosynthesis stimulated during immunogenesis.
Dvorianinovich
L N
LN
D000208:Acute Disease; D000818:Animals; D000917:Antibody Formation; D007114:Immunization; D008297:Male; D010119:Oxythiamine / Q000494:pharmacology*; D014176:Protein Biosynthesis; D051381:Rats; D013154:Spleen / Q000276:immunology / Q000378:metabolism*; D013832:Thiamine Deficiency / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism*; D013844:Thiazoles / Q000494:pharmacology*
D013844:Thiazoles; D010119:Oxythiamine
Vliianie ostrogo defitsita vitamina B1, vyzvannogo oksitiaminom, na biosintez belka v selezenke pri immunogeneze.