[Sensitivity of human tumor heterografts to a spin-labelled rubomycin derivative].
A degree of emoksil activity has been determined by applying the subrenal capsule assay methodology to fresh surgical explants of the normal immunocompetent mice. The ability of emoksil to inhibit growth of breast and colon tumours xenografts was determined. Emoksil substitution for adriamycin in the combination therapy increases the therapeutic activity. The kinetic criterion kappa calculated by the method of equivalent exponents was suggested to determine the tumour susceptibility to the drugs.
Konovalova
N P
NP
D'iachkovskaia
R F
RF
Ganieva
L Kh
LKh
Volkova
L M
LM
Lapshin
I M
IM
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D013113:Spin Labels; D013370:Subrenal Capsule Assay; D014183:Transplantation, Heterologous
D013113:Spin Labels; D004317:Doxorubicin; C042480:ruboxyl; D003520:Cyclophosphamide; D005472:Fluorouracil; D003630:Daunorubicin
Chuvstvitel'nost' geterotransplantatov opukholeĭ cheloveka k spin-mechenomu proizvodnomu rubomitsina.