title: [Congenital alcoholic cardiomyopathy in 3 children].
abstract: Three cases of congenital alcoholic cardiomyopathy and cardiac defects in children are described. The mothers were heavy spirits drinkers. One child had a ventricular septal defect, two had Fallot's tetralogy, all requiring operation. At open-heart surgery left-ventricular myocardial biopsies were obtained in all three children. Histological and electronmicroscopic examination revealed primary toxic and hypotrophic changes, which differed from those seen in alcoholic cardiomyopathy of the adult. The cells, their nuclei and the myofibrils had reduced diameters. The mitochondria were damaged to differing extent. The myofibrils were arranged in parallel and some had contraction bands and ruptures. The sarcoplasmic reticulum was dilated and had vacuoles. The cell surface penetrated into the interstitial tissue. All these changes could have resulted from inhibited embryofetal cell growth and cytotoxic damage by alcohol during pregnancy. It would seem that alcoholic cardiomyopathy occurs only in extreme forms of alcohol abuse during pregnancy. The prognosis is as yet unknown.
authors.affiliation: Klinik für Kinderkardiologie, Universität Münster.
authors.forename: H
authors.initials: H
authors.lastname: Löser
authors.forename: H
authors.initials: H
authors.lastname: Themann
authors.forename: W
authors.initials: W
authors.lastname: Welim
authors.forename: H
authors.initials: H
authors.lastname: Dittrich
mesh_terms: D002310:Cardiomyopathy, Alcoholic / Q000150:complications / Q000151:congenital* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000601:surgery; D006801:Humans; D009206:Myocardium / Q000473:pathology; D013771:Tetralogy of Fallot / Q000150:complications / Q000601:surgery
vernacular_title: Konnatale Alkoholkardiomyopathie bei drei Kindern.