Soil adsorption alters bioavailability of benzene in dermally exposed male rats.
The potential for exposure to chemically contaminated soil is a concern for chemical industry and waste disposal site workers as well as for individuals living near the contamination site. Current assessment of potential health risks from these types of exposures relies almost exclusively on extrapolations from data derived with pure chemicals. Complex interactions with soil, however, may alter greatly the way in which a chemical subsequently interacts with the body. This study was conducted to determine if soil adsorption alters the way in which benzene, a common chemical contaminant, enters and is handled by the body following dermal exposure. A shallow glass cap covering approximately a 13-cm2 area was fixed tightly to the shaved skin of each adult male rat tested; 300 microL of 14C-benzene alone or with 1 g of clay or sandy soil was introduced under the cap through an opening which was sealed immediately. Pure benzene produced the highest peak plasma concentration of radioactivity, followed closely by sandy soil-adsorbed benzene, with the lowest value exhibited by clay soil-adsorbed benzene. The plasma elimination half-lives were as follows:sandy (24.5 hr), pure (23.0 hr), and clay (19.4 hr). The tissue concentrations of radioactivity 48 hr post administration were highest in treated skin (covered by the glass cap), followed by the kidney and liver in both soil-treated groups, and were highest in the kidney followed by the liver and treated skin in the pure group.(ABSTRACT TRUNCATED AT 250 WORDS)
Skowronski
G A
GA
Pharmacology Department, New Jersey Medical School, Newark.
Turkall
R M
RM
Abdel-Rahman
M S
MS
D000327:Adsorption; D000818:Animals; D001554:Benzene / Q000097:blood / Q000378:metabolism* / Q000633:toxicity; D001682:Biological Availability; D002250:Carbon Radioisotopes; D006207:Half-Life; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects*; D012989:Soil Pollutants / Q000633:toxicity*; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D012989:Soil Pollutants; D001554:Benzene