Bioactivity of synthetic human pancreastatin on exocrine pancreas.
A biological activities of synthetic human pancreastatin (1-52) and its C-terminal fragment (24-52) were evaluated for the first time in the conscious rats. Both pancreastatins inhibited CCK-stimulated pancreatic secretion in a range of 20-200 pmol/kg/h with the same potency, indicating that the C-terminal portion of this peptide has a full biological activity. The relative molar potency of this substance compared to that of porcine pancreastatin was equivalent. This study suggests that human pancreastatin has the same biological activity as that of porcine, and plays a biological action in the exocrine pancreas.
Funakoshi
A
A
National Kyushu Cancer Center, Fukuoka, Japan.
Miyasaka
K
K
Nakamura
R
R
Kitani
K
K
Funakoshi
S
S
Tamamura
H
H
Fujii
N
N
Yajima
H
H
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology; D053379:Chromogranin A; D006801:Humans; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010187:Pancreatic Hormones / Q000494:pharmacology*; D010454:Peptide Termination Factors / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D053379:Chromogranin A; D010187:Pancreatic Hormones; D010454:Peptide Termination Factors; D011506:Proteins; C050836:pancreastatin; D002766:Cholecystokinin