Effects of vinyl acetate and acetaldehyde on sperm morphology and meiotic micronuclei in mice.
The testicular genotoxic effects of vinylacetate (VA) and its hydrolysis product, acetaldehyde (AA), were studied in mice by analyzing the induction of morphologically abnormal sperm and meiotic micronuclei. VA significantly increased the frequency of sperm abnormalities at 500 mg/kg/day while lower doses were ineffective. AA did not induce abnormal sperm. Neither of the compounds influenced the frequency of meiotic micronuclei. VA, but not AA, caused a dose-dependent decrease in sperm production and a reduction of testicular weight at 500 and 125 mg/kg/day.
Lähdetie
J
J
Department of Medical Genetics, University of Turku, Finland.
D000079:Acetaldehyde / Q000633:toxicity*; D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D003520:Cyclophosphamide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D008540:Meiosis; D051379:Mice; D013076:Sperm Count / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects* / Q000648:ultrastructure; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects*; D014753:Vinyl Compounds / Q000633:toxicity*
D014753:Vinyl Compounds; D003520:Cyclophosphamide; D000079:Acetaldehyde; C011566:vinyl acetate