[Mechanism of the action of baclofen on the contractile activity of the myocardium and blood vessels].
The cardiovascular effects of GABA-analogous-baclofen (10(-5) M) have been investigated in the experiments on isolated myocardium and vessels of the rats. The spontaneous contraction of vena porta segments and contraction of papillary muscle and arterial rings segments induced by electrostimulation were registered. Baclofen induced the growth of arterial tonus, decreased the amplitude of phase contraction as well as resulted in positive inotropic effects in myocardium and vena porta. The obsidan did not influence the baclofen effects, but alpha-adrenolytic dihydroergotoxine inhibited the inotropic effects of the drug. It is supposed that hypertensive baclofen effect which is observed during system injection may be caused not only by central, but also by peripheral regulation of calcium change in the myocytes. The latter (possible) kind of regulation may consist in the drug binding with adrenoreceptor and/or direct influence on the calcium transport across sarcolemma.
Darinskiĭ
Iu A
IuA
Egorov
V Ia
VIa
Smirnova
T A
TA
Ignatov
Iu D
IuD
Dmitriev
A V
AV
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001808:Blood Vessels / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012508:Sarcolemma / Q000378:metabolism
D001418:Baclofen; D002118:Calcium
Mekhanizm deĭstviia baklofena na sokratitel'nuiu aktivnost' miokarda i sosudov.