title: Ischemic hepatitis in children: diagnosis and clinical course.
abstract: Hepatic hypoperfusion can result in ischemic hepatitis, a clinical syndrome characterized by a sudden rise in serum transaminases followed by resolution to near normal levels within 7 to 10 days. Although described in adults, this syndrome has not been well defined in pediatric patients. We report 22 children who developed ischemic hepatitis during an acute illness. Fifteen of 22 patients had a documented hypotensive episode or no cardiac output before the onset of the ischemic hepatitis episode. Four of the seven patients without documented hypotension required pressor therapy to maintain their BP. SGOT showed a marked rise (mean 2294 IU/L, range 438 to 6652) from admission to 96 h (mean 34) with a rapid decline to near normal levels within 9 days (mean 5.1). Serum bilirubin levels also rose transiently, but generally not to the extent of transaminase levels. A clinically significant coagulopathy occurred in six patients. Although nine patients expired, none died as a direct result of the hepatic damage. Ischemic hepatitis can occur during illnesses associated with diminished hepatic blood flow and follows a characteristic course that usually can be differentiated from viral or drug-induced hepatitis on clinical and biochemical criteria.
authors.affiliation: Department of Pediatrics, Medical College of Wisconsin, Milwaukee.
authors.forename: J S
authors.initials: JS
authors.lastname: Garland
authors.forename: S L
authors.initials: SL
authors.lastname: Werlin
authors.forename: T B
authors.initials: TB
authors.lastname: Rice
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006505:Hepatitis / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007362:Intensive Care Units; D007511:Ischemia / Q000150:complications / Q000175:diagnosis* / Q000201:enzymology; D008099:Liver / Q000098:blood supply*; D008111:Liver Function Tests; D008297:Male; D008499:Medical Records; D011379:Prognosis
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase