title: Omphalophlebitis and osteomyelitis associated with Klebsiella septicemia in a premature foal.
abstract: Gram-negative neonatal septicemia was diagnosed in a premature Standardbred colt. Clinical signs included lethargy, weakness, loss of suckle reflex, tachypnea, and injected mucous membranes. Sequelae included pneumonia, omphalophlebitis, septic arthritis, and osteomyelitis. Prepartum maternal uterine infection, premature delivery, abnormal parturition with premature fetal membrane separation, and failure of passive transfer of colostral immunoglobulins increased the foal's risk for developing sepsis. Treatment included administration of moxalactam disodium and cefadroxil. The clinical efficacy of cephalosporin antibiotics in the treatment of gram-negative sepsis is discussed.
authors.affiliation: Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, Kennett Square 19348.
authors.forename: W E
authors.initials: WE
authors.lastname: Vaala
authors.forename: E S
authors.initials: ES
authors.lastname: Clark
authors.forename: J A
authors.initials: JA
authors.lastname: Orsini
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D006734:Horse Diseases / Q000151:congenital* / Q000000981:diagnostic imaging / Q000382:microbiology; D006736:Horses; D007710:Klebsiella Infections / Q000150:complications / Q000151:congenital / Q000662:veterinary*; D008297:Male; D010019:Osteomyelitis / Q000150:complications / Q000151:congenital / Q000000981:diagnostic imaging / Q000382:microbiology / Q000662:veterinary*; D010689:Phlebitis / Q000150:complications / Q000151:congenital / Q000382:microbiology / Q000662:veterinary*; D011859:Radiography; D018805:Sepsis / Q000150:complications / Q000151:congenital / Q000662:veterinary*