Effect of 25-hydroxyvitamin D3 on Na+-dependent D-glucose transport in rachitic rats.
We have previously reported that feeding rats on Steenbock and Black's rickets-inducing diet, deficient in vitamin D and with an altered Ca/P ratio, leads to metabolic consequences and a marked decrease of Na+-dependent D-glucose uptake at the jejunum-ileum level. To clarify the relationship between experimental rickets and D-glucose uptake, 25-hydroxyvitamin D3 (25-OH-D3) was given to rats fed on the rickets inducing diet. In the jejunum-ileum of these animals Na+-dependent D-glucose uptake returned to the values of the controls while the decrease in D-glucose uptake in the brush-border membrane vesicles prepared from kidney cortex of rachitic animals was not corrected by the administration of 25-OH-D3.
Treves
C
C
Institute of Biochemistry, University of Florence, Italy.
Favilli
F
F
Stio
M
M
Iantomasi
T
T
Vincenzini
M T
MT
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002112:Calcifediol / Q000494:pharmacology*; D004032:Diet; D005947:Glucose / Q000378:metabolism*; D007082:Ileum / Q000378:metabolism; D066298:In Vitro Techniques; D007583:Jejunum / Q000378:metabolism; D007672:Kidney Cortex / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012279:Rickets / Q000209:etiology / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
D012964:Sodium; D005947:Glucose; D002112:Calcifediol