title: Synthetic ferrichrome analogues with growth promotion activity for Arthrobacter flavescens.
abstract: Two families of trihydroxamic acid analogues of ferrichrome were chemically synthesized and tested for biological activity with Arthrobacter flavescens. Compounds using a tertiary amine as anchor showed little activity. Several compounds using tetrahedral carbon as anchor showed activity approaching or equalling that of the natural siderophore, ferrichrome. The biological activity is discussed in relation to physical and chemical properties of the analogues.
authors.affiliation: Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Shanzer
authors.forename: J
authors.initials: J
authors.lastname: Libman
authors.forename: R
authors.initials: R
authors.lastname: Lazar
authors.forename: Y
authors.initials: Y
authors.lastname: Tor
authors.forename: T
authors.initials: T
authors.lastname: Emery
mesh_terms: D001173:Arthrobacter / Q000187:drug effects* / Q000254:growth & development; D005291:Ferrichrome / Q000494:pharmacology*; D006133:Growth Substances; D006877:Hydroxamic Acids / Q000494:pharmacology*; D008024:Ligands; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
chemical_list: D006133:Growth Substances; D006877:Hydroxamic Acids; D008024:Ligands; D005291:Ferrichrome