title: Sister chromatid exchanges in the lymphocytes of patients with oral leukoplakia.
abstract: The incidence of sister chromatid exchange (SCE) was investigated in lymphocyte chromosomes of 59 patients with oral leukoplakia and 65 age- and sex-matched nonsmoking controls. The frequency of SCE was found to be 8.61 +/- 1.89 in patients with oral leukoplakia, which was significantly higher than the mean SCE value of 5.58 +/- 1.26 observed in normal controls. The frequency of SCE in patients with oral leukoplakia addicted to the single habit of betel with tobacco chewing, bidi/cigarette smoking, and combined habits of chewing and smoking of tobacco were found to be 7.95 +/- 1.63, 8.17 +/- 1.66, and 9.23 +/- 2.14, respectively. These values were also significantly higher as compared to the SCE values observed in normal controls.
authors.affiliation: Department of Anthropology, University of Delhi, India.
authors.forename: R
authors.initials: R
authors.lastname: Ghosh
authors.forename: J K
authors.initials: JK
authors.lastname: Sharma
authors.forename: P K
authors.initials: PK
authors.lastname: Ghosh
mesh_terms: D000328:Adult; D006801:Humans; D007972:Leukoplakia, Oral / Q000209:etiology / Q000235:genetics*; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D010947:Plants, Toxic; D012854:Sister Chromatid Exchange; D012907:Smoking / Q000009:adverse effects; D014030:Tobacco, Smokeless