[The humoral and cell-mediated immune response induced by the NIVGRIP inactivated influenza vaccine].
A comparative study was conducted in patients vaccinated with the NIVGRIP trivalent inactivated influenza vaccine and in placebo receiving controls on the kinetics of the serum hemagglutination inhibiting (HAI) antibodies and the neutralizing secretory antibodies in the nasopharyngeal secretions (NPS), of the blastic transformation of lymphocytes index, of the rosette formation index and of the serum immunoglobulins. A significant rise of the H.A.I. and the neutralizing secretory antibodies as well as of the blastic transformation of lymphocytes index was recorded after stimulation with the influenza vaccine. There were no significant changes in controls. No significant variations of the blastic transformation of lymphocytes index after stimulation with P.P.D. and of the rosette formation index were recorded in both investigated groups. Serum immunoglobulin titres showed significant variations in vaccinated as well as in control groups. The results point out the stimulating effect of the NIVGRIP inactivated influenza vaccine on both humoral and cell mediated immune responses.
Mihail
A
A
Institut de Virologie Stefan S. Nicolau, Bucarest, Roumanie.
Steiner
N
N
Berca
C
C
Jucu
V
V
Muşat
G
G
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D004341:Drug Evaluation; D006801:Humans; D007111:Immunity, Cellular; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D008213:Lymphocyte Activation; D012397:Rosette Formation; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology*
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated
Recherches sur la réponse immunitaire humorale et médiée par les cellules induite par le vaccin antigrippal inactivé NIVGRIP.