title: IgE-producing low-grade non-Hodgkin lymphoma.
abstract: An unusual case of IgE-producing non-Hodgkin lymphoma (NHL) is presented. The patient's history included a 6-year period of increasing IgE level before a low grade NHL was diagnosed. The patient developed lymph node, skin, bone marrow and lung infiltrations. With a cytostatic combination therapy a temporary improvement was achieved, but the patient died from progressive disease after 2 yr. The morphological appearance of the tumour varied between that of LP immunocytoma and a centrocytic lymphoma. Immunophenotype studies showed intracytoplasmic IgE lambda in tumour cells and B-cell surface phenotype (BB-1 pos; OKT 10 pos; PCA weakly pos and SIgE lambda).
authors.affiliation: Department of Pathology, University Hospital, University of Uppsala, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Sundström
authors.forename: K
authors.initials: K
authors.lastname: Nilsson
authors.forename: G
authors.initials: G
authors.lastname: Brenning
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D008214:Lymphocytes / Q000145:classification / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000032:analysis* / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis*
chemical_list: D009363:Neoplasm Proteins; D007073:Immunoglobulin E