title: The long march of the cerebrospinal fluid profile indicative of clinical definite multiple sclerosis; and still marching.
abstract: Much progress has been made, especially in the last two decades, in laboratory aids to diagnosis and to follow the course of patients with multiple sclerosis (MS). The cerebrospinal fluid (CSF) profile indicative of MS, though not pathognomonic of MS, is present in almost every case of clinical definite MS in a chronic progressive phase (probably also true for early MS). The cardinal aspect of the profile is intra-blood-brain barrier (BBB) IgG synthesis which can be qualitatively detected by determining unique CSF oligoclonal IgG bands and quantitated by rate formula, mg/day. We believe that intra-BBB IgG synthesis is caused by a persistent antigen, most likely a virus, possibly measles. A number of issues about the profile are proposed and opportunities are presented to resolve them.
authors.affiliation: Neurology Service, VAMC West Los Angeles, Wadsworth Division, CA 90073.
authors.forename: W W
authors.initials: WW
authors.lastname: Tourtellotte
authors.forename: R W
authors.initials: RW
authors.lastname: Baumhefner
authors.forename: K
authors.initials: K
authors.lastname: Syndulko
authors.forename: P
authors.initials: P
authors.lastname: Shapshak
authors.forename: M
authors.initials: M
authors.lastname: Osborne
authors.forename: G
authors.initials: G
authors.lastname: Rubinshtein
authors.forename: L
authors.initials: L
authors.lastname: Newton
authors.forename: G
authors.initials: G
authors.lastname: Ellison
authors.forename: L
authors.initials: L
authors.lastname: Myers
authors.forename: I
authors.initials: I
authors.lastname: Rosario
mesh_terms: D000906:Antibodies / Q000032:analysis; D001812:Blood-Brain Barrier; D002555:Cerebrospinal Fluid / Q000166:cytology / Q000378:metabolism; D003937:Diagnosis, Differential; D004586:Electrophoresis / Q000379:methods; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000628:therapy; D012709:Serum Albumin / Q000032:analysis
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G; D012709:Serum Albumin