title: The effects of controlled oxygen therapy on ventricular function in patients with stable and decompensated cor pulmonale.
abstract: We made simultaneous measurements of pulmonary hemodynamics, cardiac output, and right ventricular ejection fraction (RVEF) to assess the right ventricular function in 14 patients with pulmonary arterial hypertension as a result of chronic obstructive pulmonary disease (COPD). From these measurements, the right ventricular end-systolic pressure/volume relationship could be calculated and used to assess right ventricular contractility. Eight of the patients were clinically stable, without edema, and 6 presented acutely with gross edema, indicating decompensated cor pulmonale. Measurements were made at rest, while breathing air and oxygen. Although mean pulmonary arterial pressure (Ppa) was similar in those with (Ppa = 33 +/- 6 mm Hg) and without edema (Ppa = 30 +/- 8 mm Hg, p greater than 0.05), RVEF was lower in edematous (RVEF = 0.23 +/- 0.11) compared with non-edematous patients (RVEF = 0.47 +/- 0.04, p less than 0.01). Cardiac output was normal in both groups. The mean right ventricular end-systolic pressure/volume ratio (P/V) was lower in those patients with edema (P/V = 0.41 +/- 0.27), as compared with those without edema (P/V = 1.69 +/- 0.35, p less than 0.05), as a result of an increase in right ventricular end-systolic volume index. Similarly, left ventricular end-systolic volumes were higher in edematous than in non-edematous patients. Breathing 1 to 3 L/min of oxygen for 30 min decreased total pulmonary vascular resistance (p less than 0.05) in those patients without edema, but not in patients with edema. Oxygen did not change RVEF, left ventricular ejection fraction (LVEF), or the ventricular end-systolic P/V relationships.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, Royal Infirmary, Edinburgh, Scotland, United Kingdom.
authors.forename: W
authors.initials: W
authors.lastname: MacNee
authors.forename: C G
authors.initials: CG
authors.lastname: Wathen
authors.forename: D C
authors.initials: DC
authors.lastname: Flenley
authors.forename: A D
authors.initials: AD
authors.lastname: Muir
mesh_terms: D000208:Acute Disease; D002302:Cardiac Output; D006321:Heart / Q000503:physiopathology*; D006352:Heart Ventricles; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D000860:Hypoxia / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D008173:Lung Diseases, Obstructive / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D010100:Oxygen / Q000627:therapeutic use*; D011652:Pulmonary Circulation; D011654:Pulmonary Edema / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D011660:Pulmonary Heart Disease / Q000188:drug therapy* / Q000503:physiopathology; D013318:Stroke Volume
chemical_list: D010100:Oxygen