title: Silent stroke in the NINCDS Stroke Data Bank.
abstract: Previous brain infarctions seen on CT are common in the absence of history of stroke. Eleven percent of patients (135/1,203) without stroke history had ischemic lesions on their first CT, unrelated to the presenting stroke. Stroke Data Bank files were reviewed to determine whether the occurrence, location, and CT characteristics of those lesions are associated with their undetected status. Two distinct patterns were seen: (1) Small lesions of 1 cm or less were left hemisphere predominant and involved the deep structures of the brain; the majority of these were clinically silent. (2) Lesions greater than 1 cm occurred more frequently in the right hemisphere and were mostly superficial; these infarcts produced signs unrecognized by the patient or family. Risk factors for silent stroke were similar to those for stroke in general. Frequencies of in-hospital complications and 30-day fatality rates from the presenting stroke were not influenced by the existence of a prior silent stroke.
authors.affiliation: Department of Neurology, Boston University School of Medicine, MA 02118.
authors.forename: E H
authors.initials: EH
authors.lastname: Chodosh
authors.forename: M A
authors.initials: MA
authors.lastname: Foulkes
authors.forename: C S
authors.initials: CS
authors.lastname: Kase
authors.forename: P A
authors.initials: PA
authors.lastname: Wolf
authors.forename: J P
authors.initials: JP
authors.lastname: Mohr
authors.forename: D B
authors.initials: DB
authors.lastname: Hier
authors.forename: T R
authors.initials: TR
authors.lastname: Price
authors.forename: J G
authors.initials: JG
authors.lastname: Furtado
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007256:Information Systems; D002546:Ischemic Attack, Transient; D008297:Male; D008875:Middle Aged; D009316:National Institutes of Health (U.S.); D014057:Tomography, X-Ray Computed; D014481:United States