title: Use of a pharmacological indicator to monitor compliance with thyroxine.
abstract: Poor compliance with medication is often suspected, but difficult to confirm. The compliance of fourteen newly diagnosed hypothyroid patients was assessed using both TSH levels and low-dose phenobarbitone as a pharmacological marker. The study confirms the value of phenobarbitone as an indicator of compliance over a protracted period and suggests that it could be used to differentiate under-treatment from poor compliance.
authors.affiliation: Department of Medicine, General Infirmary, Leeds, UK.
authors.forename: N D
authors.initials: ND
authors.lastname: Penn
authors.forename: S
authors.initials: S
authors.lastname: Peaker
authors.forename: A P
authors.initials: AP
authors.lastname: Griffiths
authors.forename: M
authors.initials: M
authors.lastname: Feely
authors.forename: H
authors.initials: H
authors.lastname: Tindall
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy*; D008875:Middle Aged; D010349:Patient Compliance; D010634:Phenobarbital / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D013972:Thyrotropin; D013974:Thyroxine; D010634:Phenobarbital