title: Treatment with natural human interferon alpha of a CML-patient with antibodies to recombinant interferon alpha-2b.
abstract: A patient with Philadelphia-chromosome positive chronic myelogenous leukemia developed interferon antibodies on treatment with recombinant interferon alpha-2b. Clinically this event corresponded with progressive disease. No cross-reactivity of antibodies with human leukocyte interferon was found by Western blot. Treatment was switched to human leukocyte interferon with an obvious clinical effect: WBC was reduced and platelet count stabilized, but the effect was transient and no hematologic remission was achieved. Human leukocyte interferon may be an alternative in CML-patients with neutralizing antibodies to recombinant interferon alpha.
authors.affiliation: Department Hematology/Oncology, Hannover Medical School.
authors.forename: M
authors.initials: M
authors.lastname: Freund
authors.forename: P
authors.initials: P
authors.lastname: von Wussow
authors.forename: J
authors.initials: J
authors.lastname: Knüver-Hopf
authors.forename: H
authors.initials: H
authors.lastname: Mohr
authors.forename: U
authors.initials: U
authors.lastname: Pohl
authors.forename: G
authors.initials: G
authors.lastname: Exeriede
authors.forename: H
authors.initials: H
authors.lastname: Link
authors.forename: H J
authors.initials: HJ
authors.lastname: Wilke
authors.forename: H
authors.initials: H
authors.lastname: Poliwoda
mesh_terms: D000917:Antibody Formation; D002066:Busulfan / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003429:Cross Reactions; D004351:Drug Resistance; D006801:Humans; D007370:Interferon Type I / Q000276:immunology* / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000276:immunology* / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012074:Remission Induction
chemical_list: D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D002066:Busulfan