[Radioprotective activity, toxicity and mechanism of action of bis-(beta-dimethyl octyl ammonium ethyl)disulfide].
Disulfide bis-(beta-dimethyl octyl ammonium ethyl) and some of its analogues were shown to have a radioprotective effect. It is suggested that the mechanism of radioprotective action of quaternary ammonium compounds involves both a temporary inhibition of DNA synthesis in radiosensitive tissues and inhibition of oxidative processes in the organism.
Vladimirov
V G
VG
Strel'nikov
Iu E
IuE
Libikova
N I
NI
Krasnil'nikov
I I
II
Kokushkina
A V
AV
D000136:Acid-Base Equilibrium / Q000187:drug effects / Q000528:radiation effects; D000818:Animals; D000931:Antidotes; D003538:Cystamine / Q000627:therapeutic use; D004247:DNA / Q000096:biosynthesis; D004220:Disulfides / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D004285:Dogs; D005260:Female; D008297:Male; D051379:Mice; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D013447:Sulfites / Q000627:therapeutic use; D014494:Unithiol / Q000627:therapeutic use
D000931:Antidotes; D004220:Disulfides; D000644:Quaternary Ammonium Compounds; D011837:Radiation-Protective Agents; D013447:Sulfites; C057750:bis(beta-dimethyl octylammonium ethyl)disulfide; D014494:Unithiol; D004247:DNA; D003538:Cystamine; C025026:sodium sulfite
Radiozashchitnaia aktivnost', toksichnost' i mekhanizm deĭstviia bis-(beta-dimetiloktilammoniĭétil)disul'fida.