title: First demonstration of recombination between the gene for Norrie disease and probe L1.28.
abstract: Norrie disease is an X-linked trait thought to be tightly linked to the anonymous probe L1.28. Here we report the first recombinational event among 24 informative meioses. This indicates there is a 4% (95% C.L. 0.1%-21%) error rate introduced by meiotic crossovers in carrier or prenatal diagnosis based on linkage between Norrie disease and L1.28.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco.
authors.forename: S
authors.initials: S
authors.lastname: Katayama
authors.forename: M
authors.initials: M
authors.lastname: Wohlferd
authors.forename: M S
authors.initials: MS
authors.lastname: Golbus
mesh_terms: D001766:Blindness / Q000235:genetics*; D015342:DNA Probes; D005808:Genes, Recessive; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic; D014960:X Chromosome
chemical_list: D015342:DNA Probes