[Natural killer activity in influenza patients].
The activity of natural killers (NK) for K-562 target cells (human myeloleukemia cells) was determined in 20 patients with influenza complicated with pneumonia and in 11 patients with uncomplicated influenza. The influence of the autologous blood serum and recombinant alpha 2-interferon (reaferon) on NK activity was studied in vitro. In uncomplicated influenza, the activity of natural killers in the acute period of the disease was higher, and in patients with influenza complicated by pneumonia lower than in normal subjects. In the convalescent period, the activity of natural killers increased or approached the norm in complicated cases, and the average values showed no significant difference from those in normal subjects. The stimulating effect of the autologous blood serum and reaferon on the activity of natural killers in patients with complicated influenza was demonstrated in vitro.
Savitskiĭ
G I
GI
Grishchenko
S V
SV
Krylov
V F
VF
Kolobukhina
L V
LV
Kniazeva
L D
LD
D000293:Adolescent; D000328:Adult; D000368:Aged; D002478:Cells, Cultured; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D007251:Influenza, Human / Q000150:complications / Q000276:immunology*; D007370:Interferon Type I / Q000494:pharmacology; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008875:Middle Aged; D011024:Pneumonia, Viral / Q000209:etiology / Q000276:immunology; D011994:Recombinant Proteins
D007106:Immune Sera; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins
Aktivnost' estestvennykh killerov u bol'nykh grippom.