title: A technique to study splanchnic metabolism in the unrestrained conscious pig.
abstract: In recent years similarities recognized between porcine and human anatomy and physiology have made the pig an experimental animal of considerable value in biomedical research. We developed a pig model for unrestrained repeated sampling of portal and arterial blood, and selectively of small and large bowel veins. Catheters were inserted, under halothane anesthesia, in ten female crossbred (Yorkshire x Dutch Landrace) piglets (8 weeks; 20 +/- 2 kg). After recovery for at least 3 days the catheters were used for sampling of blood. Aortic and portal catheters patency rates were 60% at day 24. For the small bowel catheters, a patency rate of 30% was seen at day 24. The large bowel patency rate was 30% at day 10. These results are promising because they allow long-term metabolic splanchnic research in unrestrained piglets.
authors.affiliation: Department of Surgery, University of Limburg, Maastricht, The Netherlands.
authors.forename: C L
authors.initials: CL
authors.lastname: van Berlo
authors.forename: A E
authors.initials: AE
authors.lastname: van den Bogaard
authors.forename: M C
authors.initials: MC
authors.lastname: Bost
authors.forename: P B
authors.initials: PB
authors.lastname: Soeters
mesh_terms: D000818:Animals; D001011:Aorta; D001800:Blood Specimen Collection / Q000662:veterinary*; D002408:Catheters, Indwelling; D005260:Female; D007422:Intestines / Q000098:blood supply; D011169:Portal Vein; D012149:Restraint, Physical; D013552:Swine / Q000097:blood*; D014680:Veins