Plasma lipids and their fatty acid composition in multiple sclerosis.
We report an extensive study of the plasma lipid profile and fatty acid composition in 61 multiple sclerosis (MS) patients compared with 61 normal subjects. The main abnormality in the MS was a reduction in the proportion of linoleic and arachidonic acids mostly evident in the HDL and in the cholesteryl esters fraction, with a compensatory increase in saturated acids. The fatty acid abnormalities correlated with the duration of the disease and the degree of disability. Thus, in the MS patients studied there was a deficiency in essential fatty acids, although this metabolic abnormality does not seem specific to MS.
Navarro
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Department of Physiology, Autonomous University of Barcelona, Spain.
Segura
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R
D000328:Adult; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood*; D010743:Phospholipids / Q000097:blood; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D005227:Fatty Acids; D008055:Lipids; D008074:Lipoproteins; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol