[Effects of castration and estradiol dipropionate on carcinogenesis of methylcholanthrene-induced gallbladder cancer in male hamsters].
The study used 8 groups of 8-10 week-old male hamsters. Beeswax pellets containing 5 mg of 20-methylcholanthrene (group 4) or 2 mg (group 5) were injected into the gallbladder. In group 6, the latter treatment was supplemented with castration and subcutaneous injection of 40 micrograms of estradiol dipropionate (EP) once a week. Other experimental exposures included: sham operation (group 2), beeswax pellet injection into the gallbladder (group 3), beeswax pellet injection + castration + EP (group 7) and castration + EP (group 8) with the animals is group 1 being in control. The gallbladder tumor development frequency in groups 4, 5 and 6 was 58.3; 39.3 and 77.8%, respectively. The difference between the data on group 5 and 6 proved significant. The study on cumulative likelihood of tumor development showed a significant increase in tumor frequency in group 6 as compared with group 4 and 5. A strong stimulating effect of castration and EP treatment on tumorigenesis in the gallbladder was demonstrated.
Gorin
B Ia
BIa
Turusov
V S
VS
Parfenov
Iu D
IuD
D000818:Animals; D002369:Castration / Q000009:adverse effects*; D006224:Cricetinae; D004958:Estradiol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D005706:Gallbladder Neoplasms / Q000139:chemically induced / Q000209:etiology*; D007279:Injections, Subcutaneous; D008297:Male; D008748:Methylcholanthrene; D008954:Models, Biological; D013997:Time Factors
D004958:Estradiol; D008748:Methylcholanthrene; C023482:estradiol dipropionate
Vliianie kastratsii i éstradiola dipropionata na induktsiiu raka zhelchnogo puzyria metilkholantrenom u khomiakov-samtsov.