title: The handling of NaCl load in rats during DOCA-salt and Goldblatt 2 kidney-1 clip hypertension development.
abstract: The handling of an intraperitoneal NaCl load (2% body weight, 0.9% NaCl) administered twice a week during DOCA-salt and Goldblatt 2K-1C hypertension development has been evaluated. An exaggerated natriuresis was observed in DS-hypertensive rats since blood pressure became higher with respect to normal (C), Doca (D) and uninephrectomized-salt (NS) rats that served as controls. However, this phenomenon was not observed in Goldblatt 2K-1C hypertensive rats (2K-1C) when compared to the response obtained in sham-operated (SO) rats. These results suggest that: 1) An increased blood pressure, per se, is not a determinating factor for exaggerated natriuresis. 2) Rise in blood pressure and exaggerated natriuresis may be related through a common mechanism in Doca-salt hypertension.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Granada, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Vargas
authors.forename: I
authors.initials: I
authors.lastname: Casanova
authors.forename: J M
authors.initials: JM
authors.lastname: Haro
authors.forename: J D
authors.initials: JD
authors.lastname: Luna
authors.forename: C
authors.initials: C
authors.lastname: García del Río
mesh_terms: D000818:Animals; D003900:Desoxycorticosterone; D004231:Diuresis; D006973:Hypertension / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D006978:Hypertension, Renovascular / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D008026:Ligation; D008297:Male; D009318:Natriuresis; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000378:metabolism*; D013997:Time Factors
chemical_list: D003900:Desoxycorticosterone; D012965:Sodium Chloride