title: Significant reductions in mortality for children with burn injuries through the use of prompt eschar excision.
abstract: During the past 19 years, mortality due to burn injuries has markedly declined for children at the Boston Unit of the Shriners Burns Institute (SBI), dropping from an average of 9% of SBI admissions during 1968-1970 to an average of 1% during 1981-1986. Detailed statistical analysis using logistic regression was necessary for determining whether this decline in mortality was explained by changes in patient characteristics, such as age or burn size, which are known to strongly influence the outcome of burn injuries. This dramatic decline in mortality during the past 19 years was not the result of change in the age of the patients or their burn sizes; rather, it may be attributed to improvements in burn care. Results of this statistical analysis indicated that, for burn injury patients whose ages ranged from 11 days to 19 years, age had no demonstrable effect on survival from a burn injury. Children survived burn injuries at least as well if not better than the young adult (20-29 years of age). Also, infants (less than 1 year old) survived as well as other children (2-19 years old). Dramatic improvement in survival occurred in patients with burns covering more than 50% of the body surface area. Since 1979, mortality has been essentially eliminated for patients with burn sizes less than 70% of the total body surface area (of 296 patients with burns covering 15-69% of the total body surface area, only two patients died). During the period 1979-1986, 29 of 37 patients (78%) survived an 80% or greater total body surface area thermal injury.
authors.affiliation: Shriners Burns Institute, Boston, Massachusetts.
authors.forename: R G
authors.initials: RG
authors.lastname: Tompkins
authors.forename: J P
authors.initials: JP
authors.lastname: Remensnyder
authors.forename: J F
authors.initials: JF
authors.lastname: Burke
authors.forename: D M
authors.initials: DM
authors.lastname: Tompkins
authors.forename: J F
authors.initials: JF
authors.lastname: Hilton
authors.forename: D A
authors.initials: DA
authors.lastname: Schoenfeld
authors.forename: G E
authors.initials: GE
authors.lastname: Behringer
authors.forename: C C
authors.initials: CC
authors.lastname: Bondoc
authors.forename: S E
authors.initials: SE
authors.lastname: Briggs
authors.forename: W C
authors.initials: WC
authors.lastname: Quinby
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000367:Age Factors; D000704:Analysis of Variance; D001830:Body Surface Area; D001900:Boston; D002056:Burns / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003646:Debridement; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D012044:Regression Analysis; D012189:Retrospective Studies; D012835:Silver Nitrate / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors; D014945:Wound Healing
chemical_list: D012835:Silver Nitrate