Effect of strontium chloride on bone resorption induced by prostaglandin E2 in cultured bone.
We examined whether the bone resorption induced by PGE2 was inhibited by SrCl2 using 45Ca-labelled calvaria of CD-strain mice in tissue culture. It was found that Sr salts inhibited physiological bone resorption in a dose-dependent manner (0.1-5.0 mM) and did not act via PGE2. Accordingly, it was suggested that Sr salts did not inhibit bone resorption induced by exogenous PGE2.
Matsumoto
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Department of Dental Pharmacology, School of Dentistry, Hokkaido University, Sapporo, Japan.
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects*; D046508:Culture Techniques; D015232:Dinoprostone / Q000494:pharmacology*; D051379:Mice; D013324:Strontium / Q000494:pharmacology*
C025700:strontium chloride; D015232:Dinoprostone; D013324:Strontium