Effect of intravenous infusion of adrenaline on the cardiovascular responses to distal body subatmospheric pressure in man.
1. On two separate occasions, at least 1 week apart, seven young healthy male subjects received intravenous infusions of either adrenaline [0.27 nmol (50 ng) min-1 kg-1] or saline (154 mmol/l NaCl), plus ascorbic acid (5.68 mmol/l), over 30 min. 2. On each occasion, the subjects were exposed to distal body subatmospheric pressure (DBSP), 0 to 50 mmHg (0 to 6.65 kPa) in 10 mmHg (1.33 kPa) steps, before infusion, during the final 15 min of the infusion, and at 15 min and 30 min after the cessation of the infusion. 3. Venous adrenaline concentrations of 2.85 +/- 0.22 nmol/l were achieved during the adrenaline infusion, compared with 0.49 +/- 0.07 nmol/l during the saline infusion (P less than 0.001). At 15 min and at 30 min after cessation of the adrenaline infusion, venous adrenaline concentrations had fallen to levels similar to those achieved after the cessation of the saline infusion. 4. Heart rate rose significantly from 58 +/- 4 beats/min to 67 +/- 4 beats/min during the adrenaline infusion (P less than 0.05), but there was no further significant change in response to 50 mmHg (6.65 kPa) DBSP. At 30 min after the cessation of the adrenaline infusion, heart rate rose from 60 +/- 4 beats/min to 78 +/- 7 beats/min in response to 50 mmHg DBSP. This increase was significantly greater than that observed before the adrenaline infusion [58 +/- 4 beats/min to 69 +/- 7 beats/min during 50 mmHg (6.65 kPa) DBSP; P less than 0.01].(ABSTRACT TRUNCATED AT 250 WORDS)
Fellows
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Department of Physiology and Pharmacology, Queen's Medical Centre, Nottingham, U.K.
MacDonald
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Bennett
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O'Donoghue
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DP
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003664:Decompression; D004837:Epinephrine / Q000494:pharmacology*; D005542:Forearm / Q000098:blood supply*; D006339:Heart Rate / Q000187:drug effects*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008150:Lower Body Negative Pressure; D008297:Male; D011188:Potassium / Q000097:blood; D012039:Regional Blood Flow / Q000187:drug effects; D012964:Sodium / Q000097:blood; D014655:Vascular Resistance / Q000187:drug effects
D006454:Hemoglobins; D012964:Sodium; D011188:Potassium; D004837:Epinephrine