title: Novel antifungal antibiotics octacosamicins A and B. I. Taxonomy, fermentation and isolation, physico-chemical properties and biological activities.
abstract: Two antifungal antibiotics octacosamicins A and B were isolated from the culture broth of a strain of actinomycetes, which was identified as a strain of Amycolatopsis. These antibiotics were isolated by resin adsorption and purified by column chromatography and preparative HPLC. Both antibiotics were found to be new substances from their physico-chemical properties. They showed broad antifungal spectra.
authors.affiliation: Institute of Microbial Chemistry, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Dobashi
authors.forename: N
authors.initials: N
authors.lastname: Matsuda
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: H
authors.initials: H
authors.lastname: Naganawa
authors.forename: T
authors.initials: T
authors.lastname: Takita
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000192:Actinomycetales / Q000145:classification* / Q000378:metabolism; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D006146:Guanidines
chemical_list: D000935:Antifungal Agents; D006146:Guanidines; C058021:octacosamicin B; C058020:octacosamicin A