Effects of nicotine on platelet function.
In non-smokers, only high concentrations of nicotine (10 mM) caused platelet aggregation in platelet-rich plasma and release of 5-hydroxytryptamine (5-HT). Both responses to ADP and 5-HT were enhanced at 1 and 10 mM nicotine while they were inhibited to collagen, ristocetin, adrenaline and arachidonic acid. Lower concentrations of nicotine had no effect with any agent other than 5-HT, with which a variable enhancement of 5-HT-induced aggregation was observed. Uptake of 14C-5-HT was inhibited by nicotine at 100 microM or higher while platelet factor 3 availability was unaffected. Thus it is unlikely that direct effects of nicotine on platelets are responsible for smoking-related changes in platelet reactivity.
Pfueller
S L
SL
Department of Medicine, Monash University Medical School, Prahran, Victoria, Australia.
Burns
P
P
Mak
K
K
Firkin
B G
BG
D006801:Humans; D066298:In Vitro Techniques; D009538:Nicotine / Q000009:adverse effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D010977:Platelet Factor 3 / Q000032:analysis; D012701:Serotonin / Q000097:blood*; D012907:Smoking / Q000009:adverse effects / Q000097:blood*
D012701:Serotonin; D010977:Platelet Factor 3; D009538:Nicotine