Physiological growth hormone (GH) secretion during the recovery from psychosocial dwarfism: a case report.
We describe a 6.4 year old boy who had reversible GH insufficiency secondary to psychosocial dwarfism. On removal to a more favourable environment we observed the recovery of physiological GH secretion by progressive increase in GH pulse amplitude. These observations are relevant to our understanding of the control of GH secretion in that GH pulse frequency appears invariable and alteration in GH secretion is by pulse amplitude modulation.
Stanhope
R
R
Department of Growth and Development, Institute of Child Health, London, UK.
Adlard
P
P
Hamill
G
G
Jones
J
J
Skuse
D
D
Preece
M A
MA
D002648:Child; D004392:Dwarfism / Q000209:etiology / Q000503:physiopathology*; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D011610:Psychosocial Deprivation; D012636:Secretory Rate; D012894:Sleep Stages / Q000502:physiology; D013997:Time Factors
D013006:Growth Hormone