Giardia muris infection in mice with concurrent graft-versus-host reaction.
The effects of concurrent graft-versus-host reaction (GvHR) on the course of Giardia infection in CBA x BALB/c F1 mice have been examined, to test the hypothesis that T-cell-mediated immunity, in the form of a local DTH reaction, alters the host-parasite relationship in favour of the host by changing the physical environment of the parasite. GvHR did not enhance immunity, indeed mice infected with Giardia at a late stage of GvHR had significantly higher faecal cyst excretion and prolongation of the plateau phase of infection, indicating a degree of immunodeficiency.
Ferguson
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A
Gastro-Intestinal Unit, University of Edinburgh, Scotland.
Munro
G H
GH
D000818:Animals; D005243:Feces / Q000469:parasitology; D005260:Female; D005872:Giardia / Q000254:growth & development; D005873:Giardiasis / Q000276:immunology*; D006087:Graft vs Host Reaction; D051379:Mice