Effect of deciduogenic stimuli on protein secretion by the mouse uterus.
Instillation of oil into progesterone-primed, oestrogen-sensitized uteri of mice resulted in secretion patterns which were similar, but not identical, to those found on Day 5 of pregnancy. Stimulus-dependent responses common to pregnancy and the experimental decidual cell reaction included an early but transient increase in a 40,000 Mr basic protein and decreases in two other proteins. Some of the characteristic changes were also found after oil instillation in the progesterone-maintained 'non-receptive' uterus, even though subsequent decidualization did not occur. Instillation of cholera toxin, another deciduogenic substance, also resulted in patterns similar to those of pregnancy, including an increased secretion of a 25,000 Mr acidic protein which was only minimally produced during the oil-induced decidual cell reaction.
Nieder
G L
GL
Department of Anatomy, Wright State University School of Medicine, Dayton, Ohio 45435.
D000818:Animals; D002772:Cholera Toxin / Q000494:pharmacology; D003656:Decidua / Q000502:physiology*; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D009821:Oils / Q000494:pharmacology; D011374:Progesterone / Q000502:physiology; D011506:Proteins / Q000378:metabolism*; D013268:Stimulation, Chemical; D014599:Uterus / Q000378:metabolism*
D009821:Oils; D011506:Proteins; D011374:Progesterone; D002772:Cholera Toxin