Protein and collagen content of rat skeletal muscle following space flight.
Biochemical determinations of non-collagenous protein and hydroxyproline were made on rat skeletal muscles following 7 days of space flight aboard the NASA space shuttle mission SL-3. Relative to ground-based controls, the wet weight of each experimental muscle was significantly reduced. This was concomitant with a reduction in non-collagenous protein in the muscles. Protein concentration, however, was reduced only in slow-twitch muscles. The effect of space flight on the concentration and hydroxyproline content was different among the muscles. As a result, the loss of muscle mass in some muscles was the consequence of a reduction in both collagenous and non-collagenous proteins, while in others it was primarily the result of a non-collagenous protein loss.
Martin
T P
TP
Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada.
D000818:Animals; D001284:Atrophy / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D013026:Space Flight
D009124:Muscle Proteins; D003094:Collagen; D006909:Hydroxyproline