[Granulocytopoiesis in acute lymphoblastic leukemia in children].
The number, proliferative potential and differentiation potentialities of bone marrow granulocytic-macrophagal precursors were investigated in 130 ALL patients (77 children in the acute period of disease, 53 children in remission) and in the bone marrow of 65 controls without hematologic pathology. A decrease in the number of clonogenic precursors was observed in all stages of acute lymphoblastic leukemia, the decrease being particularly marked in the acute period of disease characterized by substantial bone marrow infiltration by leukemic cells. A decrease in the number of precursors and their proliferative potential was shown to be associated with the influence of leukemic blasts. In remission the numerical reduction of the precursor pool was determined by a cytostatic therapeutic effect. The ability to differentiation of granulocytic and macrophagal clonogenic precursors in ALL children was unchanged.
Vladimirskaia
E B
EB
Shershneva
N S
NS
Zamaraeva
N V
NV
Al Hasan
S
S
Chukanin
S N
SN
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001854:Bone Marrow Cells; D002648:Child; D002675:Child, Preschool; D003114:Colony-Forming Units Assay; D005260:Female; D006098:Granulocytes / Q000166:cytology* / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000473:pathology*; D012074:Remission Induction; D014407:Tumor Cells, Cultured
Granulotsitopoéz pri ostrom limfoblastnom leĭkoze u deteĭ.