A lethal neurotoxic reaction after intraventricular methotrexate administration.
A case of a patient with leptomeningeal metastases from an adenocarcinoma of the lung is described. She developed a fatal neurologic reaction during intraventricular administration of methotrexate. No morphologic cause of death was found during autopsy. Similar cases of acute complications are discussed, and an outline of factors that might play a role in the pathophysiology of methotrexate neurotoxicity is given.
ten Hoeve
R F
RF
Department of Neurology, Academic Hospital Maastricht, University of Limburg, The Netherlands.
Twijnstra
A
A
D000230:Adenocarcinoma / Q000188:drug therapy*; D001344:Autopsy; D002552:Cerebral Ventricles; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008175:Lung Neoplasms / Q000188:drug therapy*; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged
D008727:Methotrexate