Does hyperprolactinemia affect hepatic regeneration independent of sex steroids?
Prolactin, administered exogenously, has been shown to be trophic to the liver, causing increases in the liver weight-to-body weight ratio. In ornithine decarboxylase activity, and in thymidine kinase activity. To investigate the effect of endogenous hyperprolactinemia on hepatic regeneration, pituitary isografts were placed beneath the renal capsule in rats 2 weeks before the rats underwent a two-thirds partial hepatectomy. Prolactin levels 2 weeks after the transplant were greater in the animals with the pituitary isografts compared with levels in controls. The increase in the liver weight-to-body weight ratio after hepatectomy was similar in the rats with pituitary transplant and the controls. However, chronic hyperprolactinemia was associated with increased basal levels of ornithine decarboxylase activity and thymidine kinase activity. Both ornithine decarboxylase activity and thymidine kinase activity increased after partial hepatectomy, and the magnitude of the changes was similar for both groups of animals. The levels of estrogen receptor activity before the partial hepatectomy and the reduction in receptor activity that follows partial hepatectomy were similar in the two groups of animals. Moreover, the levels of androgen receptor activity within the liver before partial hepatectomy and the increase in receptor activity after hepatectomy were similar in the two groups of animals. Thus, chronic sustained hyperprolactinemia has no beneficial effect on the hepatic regenerative response, despite induction of both basal ornithine decarboxylase and thymidine kinase activities.
Kahn
D
D
Department of Surgery, University Health Center of Pittsburgh, PA 15261.
Gavaler
J S
JS
Makowka
L
L
Chapchap
P
P
Mazzaferro
V
V
Casavilla
A
A
Smith
M S
MS
Eagon
P K
PK
Starzl
T E
TE
Van Thiel
D H
DH
D000818:Animals; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D006498:Hepatectomy; D006966:Hyperprolactinemia / Q000503:physiopathology*; D008115:Liver Regeneration; D008297:Male; D009955:Ornithine Decarboxylase / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D011944:Receptors, Androgen / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D013937:Thymidine Kinase / Q000032:analysis
D012739:Gonadal Steroid Hormones; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D013937:Thymidine Kinase; D009955:Ornithine Decarboxylase