title: A new implemented version of program MIR (MIR II): analysis and identification of mathematical models in enzyme and transport kinetic studies.
abstract: The computer program MIR previously described (R. Bianchi, G.M. Hanozet and M. Pilone Simonetta, Comput. Prog. Biomed. 16 (1983) 189) that fits trial rate laws to enzyme and transport steady-state kinetic data by the least-squares method has been enhanced. The new version MIR II is an interactive program and it consists of five major routines and a larger number of smaller program elements to perform the linear (three different functional forms) and non-linear (eleven mathematical models) regression analysis of kinetic data from enzyme and transmembrane transport experiments, also in the presence of inhibitors. Other features of the new program include a set of statistics and tests useful for the model building process, for the development of the mathematical model and for its validation and maintenance. An algorithm for fitting a straight line taking into account errors in both x and y is also provided.
authors.affiliation: Department of General Physiology and Biochemistry, University of Milano, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Bianchi
authors.forename: G M
authors.initials: GM
authors.lastname: Hanozet
authors.forename: A
authors.initials: A
authors.lastname: Seneci
authors.forename: M P
authors.initials: MP
authors.lastname: Simonetta
mesh_terms: D000465:Algorithms; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D004064:Digestive System / Q000378:metabolism; D004798:Enzymes / Q000378:metabolism*; D007700:Kinetics; D007915:Lepidoptera; D008432:Mathematical Computing; D008905:Minicomputers; D008954:Models, Biological; D012044:Regression Analysis; D012984:Software; D012985:Software Design
chemical_list: D000596:Amino Acids; D004798:Enzymes