Conditioned taste aversion induced by motion is prevented by selective vagotomy in the rat.
The role of the vagus nerve in motion-induced conditioned taste aversion (CTA) was studied in hooded rats. Animals with complete, selective gastric vagotomy failed to form conditioned taste aversion after multiple conditioning sessions in which the conditioned stimulus (a cider vinegar solution) was drunk immediately before a 30-min exposure to vertical axis rotation at 150 degrees/s. Results are discussed with reference to the use of CTA as a measure of motion-induced "sickness" or gastrointestinal disturbance, and, because motion-induced CTA requires that both the vagus nerve and the vestibular apparatus be intact, in light of the possible convergence of vagal and vestibular functions.
Fox
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RA
Department of Psychology, San Jose State University, California 95192.
McKenna
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S
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology*; D004326:Drinking; D007699:Kinesthesis / Q000502:physiology*; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000294:innervation; D013649:Taste / Q000502:physiology*; D014630:Vagus Nerve / Q000502:physiology*