[Effect of dopamine on the blood supply and oxygen balance of the ischemic myocardium].
In acute experiments on anesthetized cats the effect of dopamine administered in doses of 1, 5, 10 and 20 g/kg intravenously and 10 g/kg/min by intravenous drip was studied. The drug (10 g/kg and 10 g/kg/min) was found to cause a significant and prolonged increase of total coronary blood flow, a growth of oxygen consumption by the myocardium, a decrease of oxygen tension in the heart muscle against the background of poorly pronounced arterial hypertension during a simultaneous administration and tendency towards arterial hypotension. When administered in doses of 1 and 5 g/kg intravenously dopamine induced little positive shifts of the parameters under study, and in a dose of 20 g/kg intravenously decreased total coronary blood flow, oxygen consumption by the heart and increased oxygen tension in the myocardium against the background of moderate arterial hypertension.
Katkov
E V
EV
Sapozhkov
A V
AV
D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004298:Dopamine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D010313:Partial Pressure
D004298:Dopamine
Vliianie dofamina na krovosnabzhenie i kislorodnyĭ balans ishemizirovannogo miokarda.