The effect of somatostatin analogue (SMS 201-995) on pancreatic blood flow.
The effect of somatostatin analogue SMS 201-995 on pancreatic blood flow was studied. In 24 dogs all vessels to the pancreas, except for the pancreaticoduodenal artery and vein, were divided. A flow probe was placed around the pancreaticoduodenal artery. The animals were divided into four groups. Control animals received a subcutaneous injection of 0.5 ml of normal saline solution. Treated animals received 0.002, 0.02, and 0.2 mg/kg of SMS 201-995 at the outset of the experiment. Mean systemic arterial blood pressure, cardiac output, and serum amylase values were monitored, in addition to pancreaticoduodenal blood flow. SMS 201-995 produced a prompt and sustained decrease in pancreatic blood flow in all treated groups compared with control animals without alteration of systemic hemodynamics. This suggests that SMS 201-995 decreases local vascular resistance, which results in decreased pancreatic blood flow.
Conway
D R
DR
Research Service, Hines Veterans Administration Hospital, Ill.
Djuricin
G
G
Prinz
R A
RA
D000818:Animals; D001158:Arteries; D001794:Blood Pressure; D002302:Cardiac Output; D004285:Dogs; D004386:Duodenum / Q000098:blood supply; D015282:Octreotide / Q000494:pharmacology*; D010179:Pancreas / Q000098:blood supply / Q000187:drug effects* / Q000502:physiology; D012039:Regional Blood Flow / Q000187:drug effects*
D015282:Octreotide