The disposition of [2,3-14C]-methyl and [2,3-14C]-2-ethylhexyl acrylate in male Wistar albino rats.
The disposition of methyl [2,3-14C]-acrylate (MA) and 2-ethylhexyl [2,3-14C]-acrylate (EHA) following intraperitoneal and oral administration to rats has been studied. The 14C found in the tissues was mainly associated with liver, kidneys and lungs. Loss of 14C from these tissues occurred fairly rapidly, excluding the rats given EHA intraperitoneally. Most of the administered acrylates underwent rapid metabolism and excretion with expired air (more than 50% of the dose and urine (10-50% of the dose). Significant differences in the rates of 14C loss from tissues and excretion occurred after intrapritoneal administration of MA and EHA. A possible cumulation of EHA in the organism was suggested.
Sapota
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Department of Metabolism of Toxic Substances, Institute of Occupational Medicine, Lódź, Poland.
D000179:Acrylates / Q000493:pharmacokinetics*; D000818:Animals; D002250:Carbon Radioisotopes; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D000179:Acrylates; D002250:Carbon Radioisotopes; C036758:2-ethylhexyl acrylate; C035956:methyl acrylate