Natural killer cell activity following thermal injury.
The role of natural killer cell activity in immunosurveillance following thermal injury remains unknown. We utilize a chromium-51-release assay of K562 targets to monitor NK activity. NK activity of peripheral blood mononuclear cells of severely burned patients (BSA greater than 20%) was determined once a week until the convalescence period was completed. From the second week after thermal injury, impairment of NK activity was demonstrated, but the differences did not reach statistical significance. However, a correlation was found between decline of NK activity and incidences of septic complications. Surprisingly, no decline in NK activity was observed in the first week after thermal injury.
Jira
M
M
Department of Medicine I, Burn Centre, Prague, Czechoslovakia.
Polacek
V
V
Strejcek
J
J
Fara
M
M
Konigova
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D002056:Burns / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000502:physiology*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D012772:Shock, Septic / Q000503:physiopathology; D013997:Time Factors