title: Immune response to H-2 class I antigens on platelets. I. Immunogenicity of platelet class I antigens.
abstract: Purified allogeneic murine platelet suspensions were found unable to induce primary anti-H-2 class I antibody or T cell proliferative responses. In contrast, the same platelet suspensions could elicit secondary anti-class I responses. The secondary responses were not due to contaminating leucocytes. Possible explanations, the lack of acolyte determinants (class II or non- H-2) on platelets or inappropriate layout and/or structure of their class I antigens, are discussed. These findings emphasize the importance of sufficient leucocyte depletion before platelet transfusion in the human.
authors.affiliation: U 93 INSERM, Saint Louis Hospital, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Frangoulis
authors.forename: D
authors.initials: D
authors.lastname: Besluau
authors.forename: M
authors.initials: M
authors.lastname: Chopin
authors.forename: L
authors.initials: L
authors.lastname: Degos
authors.forename: M
authors.initials: M
authors.lastname: Pla
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000276:immunology*; D002455:Cell Division; D006183:H-2 Antigens / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D006183:H-2 Antigens; D015395:Histocompatibility Antigens Class I