title: Doxycycline in combination chemotherapy of a rat leukemia.
abstract: Inhibition of mitochondrial protein synthesis by doxycycline (DC), a tetracycline analogue, has significant antitumor effects in several tumor systems. In the present study, the effects of continuous DC treatment combined with intermittent administration of Adriamycin or 1-beta-D-arabinofuranosyl cytosine on the growth of a rat leukemia were investigated. The presence of DC retards tumor relapse after 1-beta-D-arabinofuranosyl cytosine or Adriamycin treatment significantly. DC may therefore be of value in several modalities of antitumor treatment.
authors.affiliation: Laboratory of Physiological Chemistry, State University Groningen, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Van den Bogert
authors.forename: B H
authors.initials: BH
authors.lastname: Dontje
authors.forename: A M
authors.initials: AM
authors.lastname: Kroon
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004318:Doxycycline / Q000008:administration & dosage*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D051381:Rats
chemical_list: D003561:Cytarabine; D004317:Doxorubicin; D004318:Doxycycline