title: Atypical haplotypes linked to the beta S gene in Africa are likely to be the product of recombination.
abstract: We report here the haplotypes of 10 MstII-defined SS patients and a S/beta o thalassemia from the Central African Republic, exhibiting 7 different atypical haplotypes that are different from the typical Bantu haplotype that characterize over 93% of the beta s bearing chromosomes in that region of Africa. Of the seven atypical haplotypes, six can be easily interpreted as the result of recombination around the "hot spot" 5' of the beta gene, between a typical Bantu haplotype and other haplotypes available in the normal population. Except for one case that requires further study, this result demonstrates that the main mutational event leading to sickle hemoglobin in Bantu-speaking Africa was the mutation of the beta gene in a Bantu haplotype background.
authors.affiliation: Unite 15, I.N.S.E.R.M., C.H.U. Cochin, Paris.
authors.forename: R
authors.initials: R
authors.lastname: Srinivas
authors.forename: O
authors.initials: O
authors.lastname: Dunda
authors.forename: R
authors.initials: R
authors.lastname: Krishnamoorthy
authors.forename: M E
authors.initials: ME
authors.lastname: Fabry
authors.forename: A
authors.initials: A
authors.lastname: Georges
authors.forename: D
authors.initials: D
authors.lastname: Labie
authors.forename: R L
authors.initials: RL
authors.lastname: Nagel
mesh_terms: D000349:Africa; D000755:Anemia, Sickle Cell / Q000235:genetics*; D005796:Genes; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D009154:Mutation; D044469:Racial Groups / Q000235:genetics; D011995:Recombination, Genetic; D013789:Thalassemia / Q000235:genetics*