[Compounds similar to acyclovir. II. Synthesis of acyclic analogs of 2'-deoxynucleosides].
Acyclic analogues of nucleosides, viz.9- and 3-(1,6-dihydroxy-4-oxahex-3-yl)adenine, 9-(1,6-dihydroxy-4-oxahex-3-yl)guanine, 1-(1,6-dihydroxy-4-oxahex-3-yl)cytosine and thymine, with C3'-C4' bond of the furanose ring cleaved, have been prepared by condensation of trimethylsilyl derivatives of nucleic acid bases with 1,4,6-triacetoxy-3-oxahexane in the presence of Lewis acids followed by treatment with metanolic ammonia.
Shchaveleva
I L
IL
Smirnov
I P
IP
Kochetkova
S V
SV
Tsilevich
T L
TL
Khorlin
A A
AA
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D003853:Deoxyribonucleosides / Q000138:chemical synthesis*
D003853:Deoxyribonucleosides; D000212:Acyclovir
Soedineniia, podobnye atsikloviru. II. Sintez atsiklicheskikh analogov 2'-deoksinukleozidov.