title: A unique vascular graft concept for coronary and peripheral applications.
abstract: Synthetic vascular grafts for coronary bypass (3-4 mm inner diameter [ID], 40-100 ml/min) continue to fail despite success in high flow peripheral applications. A unique method is presented that uses a fluid dynamic approach to improve patency. A large diameter graft (5-6 mm ID) is used with an arteriovenous (AV) shunt to create a high flow rate (350-650 ml/min); a Venturi flow resistance controls the AV shunt and provides high pressure to the coronary arteries. The resulting graft can supply as many coronary arteries as required by means of side to side anastomoses upstream from the Venturi resistance. The concept was studied in a mock circulation system to analyze fluid dynamics under pulsatile flow. Mathematical models were used to study laminar and turbulent shear stresses and flow distributions over the physiologic range of Reynolds numbers. In vitro testing demonstrated little bovine red blood cell (RBC) hemolysis (0.249 mg Hb/min) compared with other devices. In vivo testing in sheep showed no significant acute changes in pulse rate or blood pressure in response to the shunt. The fluid and mathematical modeling of this concept has additional application in the study of flow past stenoses.
authors.affiliation: Possis Medical, Inc., Minneapolis, Minnesota 55427.
authors.forename: W J
authors.initials: WJ
authors.lastname: Drasler
authors.forename: M L
authors.initials: ML
authors.lastname: Jenson
authors.forename: S A
authors.initials: SA
authors.lastname: George
authors.forename: E I
authors.initials: EI
authors.lastname: Protonotarios
authors.forename: R G
authors.initials: RG
authors.lastname: Dutcher
authors.forename: P E
authors.initials: PE
authors.lastname: Duncan
authors.forename: Z C
authors.initials: ZC
authors.lastname: Possis
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000601:surgery; D001166:Arteriovenous Shunt, Surgical / Q000379:methods*; D001783:Blood Flow Velocity; D001807:Blood Vessel Prosthesis; D002339:Carotid Arteries / Q000601:surgery; D003331:Coronary Vessels / Q000601:surgery; D006325:Heart Atria / Q000601:surgery; D006461:Hemolysis; D006801:Humans; D007601:Jugular Veins / Q000601:surgery; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D012756:Sheep