The influence of oral contraceptives on hormonal and metabolic homeostasis in young adolescents.
In order to evaluate the effects of oral contraceptives on metabolic and endocrine function in teenagers, Norinyl 1/50 was begun in 46 12-17-year-old girls after a 16-hour-fasting blood sample was obtained for glucose, insulin, glucagon, growth hormone, luteinizing hormone, follicle-stimulating hormone, thyroid-stimulating hormone, prolactin, gluconeogenic substrates, total lipids, and cholesterol. Sampling was repeated at 6 and 12 months of therapy. Of the 46 patients enrolled in the study, 23 returned for follow-up after 6 months, and 13 completed the study. Blood sampling after 6 and 12 months of therapy demonstrated no significant changes (p greater than 0.05). Our results suggest that there were no changes in the metabolic or endocrine functions studied at 6 and 12 months on a medium-dose contraceptive agent.
Smith
K W
KW
Section of Adolescent Medicine, Children's Mercy Hospital, Kansas City, MO 64108.
Howard
C P
CP
Allphin
B J
BJ
Grunt
J A
JA
D000293:Adolescent; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D006706:Homeostasis / Q000187:drug effects*; D006728:Hormones / Q000097:blood*; D006801:Humans; D008656:Mestranol / Q000494:pharmacology; D008660:Metabolism / Q000187:drug effects*; D009640:Norethindrone / Q000494:pharmacology
D003277:Contraceptives, Oral, Combined; D003280:Contraceptives, Oral, Synthetic; D004338:Drug Combinations; D006728:Hormones; C014715:Norinyl; D008656:Mestranol; D009640:Norethindrone