Effect of liver damage on the level of coagulation factor II, X and VII in human and bovine plasma.
The thrombin generation test using thromboplastin reagent and synthetic substrate for thrombin and determination of factors II, X and VII using chromogenic substrates were applied to bovine and human plasma from objects with liver disease. The liver damage was accompanied with a lowering of the concentration of at least one factor of the extrinsic pathway of prothrombin activation. Use of some of these methods for laboratory diagnosis of liver damage is proposed.
Rybák
M
M
Institute of Haematology and Blood Transfusion, Praha, Czechoslovakia.
Dyrhon
V
V
Lostický
C
C
Dyrhonová
V
V
Valenta
Z
Z
D000818:Animals; D001780:Blood Coagulation Tests; D002417:Cattle; D005167:Factor VII / Q000378:metabolism*; D005170:Factor X / Q000378:metabolism*; D015951:Factor Xa; D006801:Humans; D008107:Liver Diseases / Q000097:blood* / Q000473:pathology; D011516:Prothrombin / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000378:metabolism
D005167:Factor VII; D011516:Prothrombin; D005170:Factor X; D012697:Serine Endopeptidases; D015951:Factor Xa