An experimental mouse model of Yersinia-induced reactive arthritis.
An experimental animal model of Yersinia-induced arthritis was successfully developed in mice using Yersinia enterocolitica WA. In order for the Yersinia to induce arthritis the strain had to be cured of plasmid. The arthritis-susceptible mouse strains were DBA/2 and BDF1. C57B1/6, Balb/c, CBA and DBA/1 were arthritis-resistant. Both the dose of bacteria and the route of administration were critical.
Yong
Z
Z
Department of Medicine, University of California Los Angeles 90024.
Hill
J L
JL
Hirofuji
T
T
Mander
M
M
Yu
D T
DT
D000818:Animals; D001170:Arthritis, Infectious / Q000382:microbiology*; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D010957:Plasmids; D014774:Virulence; D015009:Yersinia Infections / Q000382:microbiology*; D015008:Yersinia enterocolitica / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity