title: Potassium-depletion alkalosis in the rat.
abstract: Studies were performed to investigate the role of concomitant chloride depletion in potassium-depletion alkalosis in the rat and the relationship between potassium depletion, plasma bicarbonate (PHCO3), and net acid excretion. 1) Selective potassium depletion (K-DEPL), potassium plus chloride depletion (KCl-DEPL), or selective chloride depletion (Cl-DEPL) was produced by administering a selectively potassium-, potassium and chloride-, or selectively chloride-deficient diet. In K-DEPL and KCl-DEPL rat, PHCO3 increased progressively and similarly during a 38-day period of restriction, whereas net acid excretion was similar and not elevated in either group. Cl-DEPL did not result in alkalosis. Chloride administration without potassium in alkalotic KCl-DEPL rats did not result in a sustained significant decrease in PHCO3. Potassium administration without chloride in alkalotic KCl-DEPL rats decreased PHCO3. Thus concomitant chloride depletion plays a minimal role in the alkalosis produced by dietary-induced potassium depletion. 2) Administration of a chronic acid load to alkalotic K-DEPL rats did not decrease PHCO3, and net acid excretion increased similarly as in normals. In K-DEPL rats after PHCO3 was reduced toward normal levels with acetazolamide, net acid excretion increased sharply above base-line values and PHCO3 increased markedly. Thus the alkalotic K-DEPL rat maintains the ability to excrete a chronic acid load, and a reduction in PHCO3 elicits an increase in acid excretion to restore the initial acid-base condition. These studies suggest that potassium depletion alters the set-point at which the kidney maintains PHCO3.
authors.affiliation: Department of Medicine, Bronx Veterans Administration Medical Center, New York 10468.
authors.forename: A M
authors.initials: AM
authors.lastname: Kaufman
authors.forename: T
authors.initials: T
authors.lastname: Kahn
mesh_terms: D000086:Acetazolamide / Q000494:pharmacology; D000471:Alkalosis / Q000209:etiology / Q000503:physiopathology*; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D002712:Chlorides / Q000172:deficiency; D004573:Electrolytes / Q000097:blood / Q000652:urine; D008297:Male; D011191:Potassium Deficiency / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
chemical_list: D001639:Bicarbonates; D002712:Chlorides; D004573:Electrolytes; D000086:Acetazolamide