title: Eosinophilic leucocytes and arylsulfatase activity in bronchoalveolar lavage fluid of patients with bronchial asthma.
abstract: The arylsulfatase activity and histamine concentration of bronchoalveolar lavage fluid (BALF) were examined in patients with bronchial asthma in relation to the eosinophil count and asthma type (atopic and non-atopic). The BALF arylsulfatase activity and histamine concentration were significantly higher in atopic asthmatics than in non-atopic asthmatics. In atopic asthmatics, the activity of arylsulfatase was significantly increased in patients with a higher eosinophil count (10% or more). However, the BALF histamine concentration did not correlate with the eosinophil count. In non-atopic asthmatics, there was no significant correlation between arylsulfatase activity and the eosinophil count. The results show that arylsulfatase participates in IgE-mediated allergic reactions.
authors.affiliation: Department of Medicine, Misasa Medical Branch, Okayama University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tanizaki
authors.forename: M
authors.initials: M
authors.lastname: Sudo
authors.forename: H
authors.initials: H
authors.lastname: Kitani
authors.forename: H
authors.initials: H
authors.lastname: Araki
authors.forename: K
authors.initials: K
authors.lastname: Oki
authors.forename: M
authors.initials: M
authors.lastname: Tsuji
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: I
authors.initials: I
authors.lastname: Kimura
mesh_terms: D000328:Adult; D001192:Arylsulfatases / Q000378:metabolism*; D001249:Asthma / Q000201:enzymology*; D004112:Dimercaprol; D004804:Eosinophils / Q000502:physiology*; D006632:Histamine / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000201:enzymology; D007073:Immunoglobulin E; D007958:Leukocyte Count; D008168:Lung / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D013429:Sulfatases / Q000378:metabolism*
chemical_list: D004112:Dimercaprol; D007073:Immunoglobulin E; D006632:Histamine; D013429:Sulfatases; D001192:Arylsulfatases