Effect of chronic ethanol administration on iron metabolism in the rat.
This study shows that the ingestion of ethanol provokes alterations in iron metabolism which may lead to iron overload. Impaired release of reticuloendothelial iron was shown by a decrease of the maximum red blood cell utilization when radioactive iron was supplied as colloidal iron. An impairment in the erythropoietic activity of ethanol-treated animals was also observed, as can be seen from the reduced plasma iron turnover and red blood cell utilization within 24 h of iron administration. A rise in marrow transit time was also observed. In ethanol-treated rats there was an increase in the amount of iron retained both in the liver and the spleen. This was observed in both sexes and also in the offspring from ethanol-treated mothers.
Sánchez
J
J
Dept. Bioquímica y Fisiología, Universidad de Barcelona, Spain.
Casas
M
M
Rama
R
R
D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007501:Iron / Q000378:metabolism*; D008099:Liver / Q000032:analysis; D008297:Male; D012157:Mononuclear Phagocyte System / Q000187:drug effects / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013154:Spleen / Q000032:analysis
D006454:Hemoglobins; D000431:Ethanol; D007501:Iron