title: A study of the brain barrier in the ventral nerve cord of the American cockroach treated with hexane-acetone and DDT.
abstract: The present study examines electrophysiological alterations in the blood brain barrier of the American cockroach when the solvent hexane-acetone is applied topically to the ventral nerve cord. Rupture of the barrier was evaluated by perfusion with saline in which NaCl was replaced with choline chloride at 28 degrees and 15 degrees C. The electrophysiological effects of an ethanol DDT suspension on the ventral nerve cord previously treated with hexane-acetone at 28 degrees C and 15 degrees C were consistent with the rupture of the blood brain barrier and the negative temperature coefficient of DDT toxicity.
authors.affiliation: Departamento de Fisiologia, Universidade de São Paulo, Brasil.
authors.forename: M I
authors.initials: MI
authors.lastname: Nogueira
authors.forename: E L
authors.initials: EL
authors.lastname: Holzhacker
mesh_terms: D000096:Acetone / Q000494:pharmacology*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002794:Choline / Q000494:pharmacology; D003058:Cockroaches; D003634:DDT / Q000493:pharmacokinetics*; D005071:Evoked Potentials / Q000187:drug effects*; D006586:Hexanes / Q000494:pharmacology*
chemical_list: D006586:Hexanes; D000096:Acetone; D003634:DDT; D002794:Choline