[Regulation of lipid peroxidation induced by cumene hydroperoxide in the liver mitochondria of irradiated rats].
A study was made of the accumulation of lipoperoxidation products and O2- generation induced by cumene hydroperoxide in mitochondria of irradiated rat liver. O2- generation and formation of lipoperoxidation products were found to be connected with the function of mitochondrial P-450 cytochrome. During the first 24 h following X-irradiation of rats with a dose of 10 Gy, the rate of O2- generation sharply increased and mitochondria could not regulate the intensity of lipoperoxidation with incubation medium tonicity being altered.
Gudz'
T I
TI
Novgorodov
S A
SA
Pandelova
I G
IG
Kakabadze
G A
GA
Iaguzhinskiĭ
L S
LS
D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology*; D007477:Ions; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D010100:Oxygen; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
D001555:Benzene Derivatives; D007477:Ions; D008054:Lipid Peroxides; C007164:cumene hydroperoxide; D010100:Oxygen
Reguliatsiia lipoperoksidatsii, indutsirovannoĭ gidroperekis'iu kumila, v mitokhondriiakh pecheni obluchennykh krys.