[Effect of dietary linoleic acid on the platelet aggregation, fatty acid composition of platelet phospholipids and synthesis of platelet prostaglandins in rats].
Three groups of Wistar-Kyoto rats were kept on diets containing different quantity of linoleic acid (LA) in prenatal and postnatal periods up to 18 weeks age: I. less than 0.1 cal.% of LA, 2. 9.0 cal.% of LA and 3. 16 cal.% of LA. Aggregation of washed platelets with ADP and A23187, biosynthesis of prostaglandins from 14C-arachidonic acid in platelets and fatty acid composition of platelet phospholipids were studied using gas liquid chromatography. Modification of fatty acid composition of platelet phospholipids and changes in biosynthesis of platelet prostaglandins are the base for proaggregation effect of LA deficient and for antiaggregation effect of LA enriched diets. The effects of dietary LA were mediated not only via altered metabolism of fatty acids of linoleic family but also via metabolism of fatty acids of oleic and linolenic series.
Markov
Kh M
KhM
Atrokhov
V V
VV
Zadkova
G F
GF
Pinelis
V G
VG
Poleshchuk
V S
VS
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage*; D005227:Fatty Acids / Q000097:blood; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage*; D008297:Male; D010743:Phospholipids / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects*; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011921:Rats, Inbred WKY
D004041:Dietary Fats; D005227:Fatty Acids; D008041:Linoleic Acids; D010743:Phospholipids; D011453:Prostaglandins; D019787:Linoleic Acid
Vliianie pishchevoĭ linolevoĭ kisloty na agregatsiiu trombotsitov, zhirnokislotnyĭ sostav ikh fosfolipidov i sintez trombotsitarnykh prostaglandinov u krys.