Localization of the human X-linked gene for chronic granulomatous disease to the mouse X chromosome: implications for X-chromosome evolution.
The gene encoded at the human X-linked chronic granulomatous disease locus (cytochrome b245 beta subunit) has been mapped to the mouse X chromosome using an interspecific Mus domesticus x M. spretus cross. The localization of this gene provides detailed information on one of the proposed ancestral breakpoints that account for the divergent evolution of the mouse and human X chromosomes.
Brockdorff
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N
Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London, UK.
Fisher
E M
EM
Orkin
S H
SH
Lyon
M F
MF
Brown
S D
SD
D000818:Animals; D005075:Biological Evolution; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003573:Cytochrome b Group / Q000235:genetics; D015342:DNA Probes; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid; D012729:Sex Chromosome Aberrations / Q000235:genetics; D013045:Species Specificity; D014960:X Chromosome
D003573:Cytochrome b Group; D015342:DNA Probes; C035130:cytochrome b245