[Effect of the preparation baliz-2 on the growth of cultures of sympathetic ganglia from various strains of rats].
The effect of the baliz-2 drug (0.01%, 0.001%, 0.0001%) on the growth and differentiation of nervous tissue was studied on organotypic cultures of the sympathetic ganglia of newborn Wistar, Wag, August rats. The growth zone of explants in living cultures and histochemical stained preparations were analyzed for catecholamine-containing neurites. It has been established that control value of growth intensity for August ganglia is 2.1 2.0 times lower than for Wistar and Wag. The baliz-2 drug at concentration 0.001% and 0.0001% is able to stimulate fibre outgrowth from the explant. Mean values of the reaction are different: they are maximal for August rats (2.3-2.6 times higher than the control), while for Wistar and Wag rats they are 1.8-2.0 times higher than the control. These results provide evidence that the baliz-2 drug is a neurotrophic agent for sympathetic ganglia in culture. The results are discussed in terms of the role of the sympathetic-adrenal system in the nervous tissue regeneration.
Kozlova
M V
MV
Shurygin
A Ia
AIa
Sidorenko
I P
IP
Kalenchuk
V U
VU
D000818:Animals; D000831:Animals, Newborn; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D005728:Ganglia, Sympathetic / Q000187:drug effects* / Q000254:growth & development; D007651:Keto Acids / Q000494:pharmacology*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*
D007651:Keto Acids; D009414:Nerve Growth Factors; C057854:baliz 2
Vliianie preparata baliz-2 na rost kul'tur simpaticheskikh gangliev krys razlichnykh liniĭ.