title: Inactivation pattern of the fragile X in heterozygous carriers.
abstract: In this report we present new data on BrdU-inactivation studies in lymphocytes of five heterozygotes. The present data confirm our previous findings that the prediction of the mental status of female heterozygote carriers cannot be based on the X-inactivation pattern. The general tendency to carry the fragile site on the active X is confirmed and the results of previous studies and hypotheses are reviewed.
authors.affiliation: Centre for Human Genetics, University of Leuven, Belgium.
authors.forename: J P
authors.initials: JP
authors.lastname: Fryns
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D000328:Adult; D004303:Dosage Compensation, Genetic; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics* / Q000523:psychology; D006579:Heterozygote; D006801:Humans; D007360:Intelligence; D008214:Lymphocytes / Q000648:ultrastructure; D010641:Phenotype; D012729:Sex Chromosome Aberrations / Q000235:genetics*