HLA-DR antigens and anticardiolipin antibodies in northern Italian systemic lupus erythematosus patients.
Eighty systemic lupus erythematosus (SLE) patients attending 3 clinical centers were evaluated immunologically and immunogenetically. No HLA class II antigens were found to be significantly associated with SLE in these patients. A highly significant (P = 6.17 x 10(-7) association was observed between anticardiolipin antibodies and DR7. A lesser association (P less than 0.025) was also observed between DR2 and/or DR3 and anti-Ro (SS-A) antibodies. No relationship was found between any DR antigen and anti-Sm/RNP, anti-double-stranded DNA, or anti-La (SS-B) antibodies.
Savi
M
M
Clinical Medicine and Nephrology Department, University of Parma, Italy.
Ferraccioli
G F
GF
Neri
T M
TM
Zanelli
P
P
Dall'Aglio
P P
PP
Tincani
A
A
Balestrieri
G
G
Carella
G
G
Cattaneo
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D002308:Cardiolipins / Q000276:immunology*; D002648:Child; D015331:Cohort Studies; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007558:Italy; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies; D002308:Cardiolipins; D006680:HLA Antigens; D006684:HLA-DR Antigens