title: Erythromycin A 11,12-methylene acetal.
abstract: Erythromycin A 11,12-methylene acetal (5) and the corresponding 9-methoxime, 9-dihydro, and 8-hydroxy derivatives have been prepared and their antibacterial activities compared with those of erythromycin A and its 11,12-cyclic carbonate. The simple methylene acetal 5 showed excellent activity against Gram-positive organisms in vitro.
authors.affiliation: Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Betchworth, Surrey, UK.
authors.forename: E
authors.initials: E
authors.lastname: Hunt
authors.forename: D J
authors.initials: DJ
authors.lastname: Knowles
authors.forename: C
authors.initials: C
authors.lastname: Shillingford
authors.forename: I I
authors.initials: II
authors.lastname: Zomaya
mesh_terms: D004917:Erythromycin / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
chemical_list: D004917:Erythromycin