[Comparative radiosensitivity of clonogenic tumor cells of the transplantable Ehrlich carcinoma in the ascitic and solid forms of growth].
Survival of clonogenic cells of solid Ehrlich ascites tumor (EAT) exposed to 60Co-gamma-radiation in vitro under the oxygenation conditions was investigated and the clonogenic capacity and radiosensitivity of these cells and cells of the previously studied EAT ascitic form and Lewis solid tumor comparatively studied to elucidate how the efficiency of colony formation (ECF) would affect their radiosensitivity. ECF for solid EAT cells was 2.6 +/- 0.3%, which was lower, by about an order of magnitude, than that for ascitic form of this tumor and was nearly the same as that for Lewis tumor cells. A median cell lethal dose (D0) was practically the same for all tumors under study. It is suggested that the differences in ECF do not substantially influence the radiosensitivity of clonogenic cells of the studied tumors.
Konopliannikov
A G
AG
Kolesnikova
A I
AI
Lepekhina
L A
LA
Shteĭn
L V
LV
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D066298:In Vitro Techniques; D051379:Mice; D014411:Neoplastic Stem Cells / Q000528:radiation effects*; D011836:Radiation Tolerance
D003037:Cobalt Radioisotopes
Sravnitel'naia radiochuvstvitel'nost' klonogennykh opukholevykh kletok perevivaemogo raka Erlikha pri astsitnoĭ i solidnoĭ forme rosta.