Expression of the HST1 oncogene in human germ cell tumors.
HST1 (or HSTF1 in human gene nomenclature) is a transforming gene isolated from several cancerous and noncancerous cells. The HST1 protein is a heparin-binding growth factor with significant homology with human fibroblast growth factors and the mouse Int-2 protein. Here, we report the identification of expression of HST1 in a human teratoma cell line and in 5 out of 9 surgically resected human testicular germ cell tumors including seminomas and embryonal carcinomas. Mouse HST1 homologue was expressed in a certain stage of mouse embryo but not in postnatal mice.
Yoshida
T
T
National Cancer Center Research Institute, Tokyo, Japan.
Tsutsumi
M
M
Sakamoto
H
H
Miyagawa
K
K
Teshima
S
S
Sugimura
T
T
Terada
M
M
D000818:Animals; D004407:Dysgerminoma / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D051379:Mice; D009857:Oncogenes; D015347:RNA Probes; D013724:Teratoma / Q000235:genetics*; D013736:Testicular Neoplasms / Q000235:genetics
D015347:RNA Probes