title: Leukoencephalopathy after prophylactic radiation for leukaemia in ataxia telangiectasia.
abstract: Children with ataxia telangiectasia have a high probability of developing acute lymphoblastic leukaemia, and have increased sensitivity to chemotherapy and irradiation. We report a 51/2 year old boy who had undiagnosed ataxia telangiectasia when he presented with acute lymphoblastic leukaemia. He subsequently developed a chemoradiation induced leukoencephalopathy after conventional central nervous system prophylaxis.
authors.affiliation: Department of Child Health, Medical School, University of Newcastle upon Tyne.
authors.forename: J A
authors.initials: JA
authors.lastname: Eyre
authors.forename: D
authors.initials: D
authors.lastname: Gardner-Medwin
authors.forename: G P
authors.initials: GP
authors.lastname: Summerfield
mesh_terms: D001260:Ataxia Telangiectasia / Q000150:complications* / Q000175:diagnosis; D001921:Brain / Q000528:radiation effects; D001927:Brain Diseases / Q000209:etiology*; D001932:Brain Neoplasms / Q000517:prevention & control; D002675:Child, Preschool; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000532:radiotherapy / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects*
chemical_list: D008727:Methotrexate