title: Atherosclerosis and aging. A morphometric study on arterial lesions of elderly and very elderly necropsy subjects.
abstract: A histomorphometric study was performed on arterial wall lesions of different arterial regions (arch, thoracic, abdominal parts of the aorta; right and left common and internal carotid arteries; coronary arteries; and basilar and middle cerebral arteries), collected from 108 elderly and very elderly (greater than 90 years of age) subjects who underwent necropsy. Lumen stenosis percentage, mean intimal thickening, and mean thickness of the media were measured by means of a computerized system using a manual input and graphic printout; statistical tests were performed using variance and regression analysis. Results showed that the arterial wall lesions in patients over 60 years of age tend to be stabilized in all regions studied except for the cerebral region, where the lesions tend to have a continuous progression related to age, even in a group of subjects over 90 years of age.
authors.affiliation: Institute of Pathologic Anatomy, University of Siena, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Weber
authors.forename: G
authors.initials: G
authors.lastname: Bianciardi
authors.forename: R
authors.initials: R
authors.lastname: Bussani
authors.forename: R
authors.initials: R
authors.lastname: Gentilini
authors.forename: L
authors.initials: L
authors.lastname: Giarelli
authors.forename: M T
authors.initials: MT
authors.lastname: Novelli
authors.forename: L
authors.initials: L
authors.lastname: Resi
authors.forename: M
authors.initials: M
authors.lastname: Salvi
authors.forename: F
authors.initials: F
authors.lastname: Silvestri
authors.forename: P
authors.initials: P
authors.lastname: Tanganelli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001011:Aorta / Q000473:pathology*; D001161:Arteriosclerosis / Q000473:pathology*; D002536:Cerebral Arteries / Q000473:pathology*; D003251:Constriction, Pathologic; D006801:Humans; D007083:Iliac Artery / Q000473:pathology*; D008875:Middle Aged