title: [Maturation of the activity of cerebellar Purkinje cells and the lift reaction].
abstract: In experiments on guinea pigs (from newborn to adults), studies have been made on the extensor, support and lift reactions, as well as on the activity of cerebellar Purkinje cells in the same animals. First signs of immature lift, extensor and support reactions were observed already 12th after birth. At this period, mean discharge frequency in Purkinje cells was significantly lower than in the adult animals, reaching 11.5 +/- 1.2 imp/s for simple spikes and 0.45 +/- 0.05 imp/s for complex ones. Complete maturation of lift, extensor and support reactions takes place to the beginning of the 2nd week (8-9 days) of postnatal life. Within this period, significant changes in the activity of Purkinje cells were observed: mean discharge frequency of simple and complex spikes increased correspondingly up to 17.9 +/- 2.3 and 1.48 +/- 0.25 imp/s. At the same time, the mean discharge frequency in Purkinje cells, the average duration of inhibition pause, and the response latency became more stable.
authors.forename: R A
authors.initials: RA
authors.lastname: Grigor'ian
authors.forename: E I
authors.initials: EI
authors.lastname: Prigarina
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D002531:Cerebellum / Q000254:growth & development*; D005071:Evoked Potentials; D006168:Guinea Pigs; D008564:Membrane Potentials; D008839:Microelectrodes; D009043:Motor Activity / Q000502:physiology*; D009132:Muscles / Q000502:physiology; D009433:Neural Inhibition; D011187:Posture; D011689:Purkinje Cells / Q000502:physiology*
vernacular_title: Sozrevanie aktivnosti kletok Purkin'e mozzhechka i liftnaia reaktsiia.