title: Micronuclei in cytokinesis-blocked lymphocytes as an index of occupational exposure to alkylating cytostatic drugs.
abstract: Micronucleated peripheral blood lymphocytes were analysed in cytochalasin-B-treated binucleated lymphocytes using cytocentrifuged preparations. Increased numbers of micronuclei were observed in lymphocytes of groups of workers from industry and hospitals potentially exposed to cyclophosphamide. The finding was independent of the age of the subjects, which was also correlated with micronuclei formation.
authors.affiliation: Institute of Occupational Health, Helsinki, Finland.
authors.forename: J W
authors.initials: JW
authors.lastname: Yager
authors.forename: M
authors.initials: M
authors.lastname: Sorsa
authors.forename: S
authors.initials: S
authors.lastname: Selvin
mesh_terms: D000328:Adult; D003520:Cyclophosphamide / Q000633:toxicity*; D003571:Cytochalasin B / Q000494:pharmacology; D004784:Environmental Monitoring / Q000379:methods*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D015162:Micronucleus Tests; D008875:Middle Aged; D009790:Occupations
chemical_list: D003571:Cytochalasin B; D003520:Cyclophosphamide