title: Analogs of tetrahydrofolate directed at folate-dependent purine biosynthetic enzymes. Characteristics of mediated entry and transport-related resistance in L1210 cells for 5,10-dideazatetrahydrofolate and two 10-alkyl derivatives.
authors.affiliation: Memorial Sloan-Kettering, Cancer Center, New York, NY 10021.
authors.forename: F M
authors.initials: FM
authors.lastname: Sirotnak
authors.forename: G M
authors.initials: GM
authors.lastname: Otter
authors.forename: J R
authors.initials: JR
authors.lastname: Piper
authors.forename: J I
authors.initials: JI
authors.lastname: DeGraw
mesh_terms: D000478:Alkylation; D000818:Animals; D001692:Biological Transport; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000502:physiology; D004351:Drug Resistance; D007939:Leukemia L1210; D008727:Methotrexate / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013763:Tetrahydrofolates / Q000378:metabolism* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D013763:Tetrahydrofolates; C045894:lometrexol; D008727:Methotrexate