title: The number of clonal precursors of the follicular epithelium in the mouse ovary.
abstract: The number of clonal precursors of granulosa cells in mouse ovarian follicles has been estimated using a technique based on the phenomenon of random X-chromosome inactivation of somatic cells and the use of an X-linked alloenzyme variant of the glycolytic enzyme PGK-1. The granulosa cells of follicles were oligoclonal in origin and founded by a small number of cells (about 5) which was consistent with histological observations. When the analysis was extended to two subcompartments of the follicle, the mural and cumulus granulosa cells, the results indicated that the cumulus and mural granulosa cells had a common origin.
authors.affiliation: Department of Physiology University Medical School, Edinburgh, U.K.
authors.forename: E
authors.initials: E
authors.lastname: Telfer
authors.forename: J D
authors.initials: JD
authors.lastname: Ansell
authors.forename: H
authors.initials: H
authors.lastname: Taylor
authors.forename: R G
authors.initials: RG
authors.lastname: Gosden
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002999:Clone Cells; D004847:Epithelial Cells; D005260:Female; D006107:Granulosa Cells / Q000166:cytology / Q000201:enzymology; D051379:Mice; D008815:Mice, Inbred Strains; D006080:Ovarian Follicle / Q000166:cytology*; D010735:Phosphoglycerate Kinase / Q000378:metabolism
chemical_list: D010735:Phosphoglycerate Kinase