[A mechanism of inhibition of fibrin self-assembly by a peptide inhibitor].
The amino acid composition of fibrin self-assembly inhibitors isolated from the blood plasma of man, ox, albino rat and from frog muscle tissue was established. Using a human blood plasma inhibitor, it was found that the inhibition of fibrin self-assembly is due to the inhibitor interaction with monomeric fibrin in the sites of domain D which become accessible after fibrinogen activation by thrombin.
Chiriat'evEA
Leonova
O P
OP
Byshevskiĭ
A Sh
ASh
D000818:Animals; D002417:Cattle; D002850:Chromatography, Gel; D005337:Fibrin / Q000037:antagonists & inhibitors*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D007700:Kinetics; D010455:Peptides; D013917:Thrombin
D005338:Fibrin Fibrinogen Degradation Products; D010455:Peptides; C036309:fibrin fragment D; D005337:Fibrin; C052940:fibrin self-assembly inhibitor; D013917:Thrombin
Mekhanizm tormozheniia samosborki fibrina ingibitorom peptidnoĭ prirody.