title: Exogenous GM1 gangliosides protect against retrograde degeneration following posterior neocortex lesions in developing hamsters.
abstract: Developing and adult hamsters received unilateral neocortex aspiration lesions and were then treated daily with exogenous ganglioside (GM1, 30 mg/kg, i.p.). When lesions were made at the age of two weeks, GM1-treated animals had less shrinkage of the dorsal lateral geniculate nucleus of the thalamus compared to controls. Although a similar observation was made in adults, the effect was not as striking. Thus, GM1-treatment reduces retrograde degeneration after neocortical lesions and this effect is most pronounced during early development.
authors.affiliation: Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
authors.forename: B A
authors.initials: BA
authors.lastname: Sabel
authors.forename: J
authors.initials: J
authors.lastname: Gottlieb
authors.forename: G E
authors.initials: GE
authors.lastname: Schneider
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D006224:Cricetinae / Q000502:physiology*; D005677:G(M1) Ganglioside / Q000494:pharmacology*; D008297:Male; D008647:Mesocricetus / Q000254:growth & development / Q000502:physiology*; D009410:Nerve Degeneration / Q000187:drug effects*
chemical_list: D005677:G(M1) Ganglioside