Short course of albendazole therapy for neurocysticercosis.
Albendazole is now used for therapy of neurocysticercosis; however, duration of treatment has usually been empirically determined. In this study we shortened the length of therapy from one month in previous reports, to one week. Twelve patients with parenchymal brain cysticercosis were treated with albendazole for eight days at daily doses of 15 mg/kg of body weight. After three months of treatment the number of cysts on computed tomography had decreased from 185 to six; a 97% reduction in the number of lesions. Total remission of all cysts was seen in nine patients. Two cases had been unsuccessfully treated before with praziquantel, in both instances albendazole therapy was effective with 100% improvement. Our results indicated that a short course of albendazole is highly effective for treatment of neurocysticercosis.
Sotelo
J
J
Instituto Nacional de Neurologia-y Neurocirugia, Mexico City, DF.
Penagos
P
P
Escobedo
F
F
Del Brutto
O H
OH
D000328:Adult; D015766:Albendazole; D000871:Anthelmintics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000009:adverse effects / Q000627:therapeutic use*; D001921:Brain / Q000382:microbiology / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D003551:Cysticercosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D006423:Hemianopsia / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000209:etiology; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D000871:Anthelmintics; D001562:Benzimidazoles; D015766:Albendazole