Secretory pattern of growth hormone regulates plasma concentration of pregnancy-associated murine protein-1 in the non-pregnant rat.
Serum concentrations of pregnancy-associated murine protein-1 (PAMP-1) were followed in hypophysectomized adult female rats during treatment with oestradiol and continuous or intermittent human growth hormone (hGH). After hypophysectomy a rapid decrease in PAMP-1 values was recorded while concentrations of albumin and the acute phase alpha 2-macroglobulin were unaffected. PAMP-1 values were completely restored by continuous infusion of hGH (1.4 i.u./kg/day). Neither the same dose of hGH given as two daily injections nor oestrogen replacement treatment had any effect. It is concluded that the serum concentration of PAMP-1 in the non-pregnant rat is regulated by the sexually dimorphic secretory pattern of GH.
Eriksson
L
L
Department of Obstetrics and Gynecology, University Hospital, Umeå, Sweden.
Carlsson-Bostedt
L
L
Oscarsson
J
J
Edén
S
S
Stigbrand
T
T
von Schoultz
B
B
D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D013006:Growth Hormone / Q000378:metabolism* / Q000494:pharmacology; D007016:Hypophysectomy; D011257:Pregnancy Proteins / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D011257:Pregnancy Proteins; C033484:pregnancy-associated murine protein 1; D004958:Estradiol; D013006:Growth Hormone