[Carcinogenic effect of benz(a)pyrene depending on its mode of application to the skin of mice].
The role of dose and time factors in intensification of the carcinogenic effect is studied on the model of skin carcinogenesis in (CBA x C57Bl)F1 female mice under application of BP. The total dose is not a single parameter determining the carcinogenic effect. The single dose interval between the actions and their number are of essential importance under definite conditions. The total time (T) of the carcinogen action is a significant factor. The total and single doses and the number of carcinogen applications to the mouse skin being similar, the effect is the stronger, the longer is T, i.e. the longer is the interval between certain applications of the carcinogen.
Kosoĭ
G Kh
GKh
Parfenov
Iu D
IuD
Turusov
V S
VS
D000279:Administration, Cutaneous; D000818:Animals; D001564:Benzo(a)pyrene / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012867:Skin / Q000187:drug effects*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D013997:Time Factors
D001564:Benzo(a)pyrene
Kantserogennyĭ éffekt benz(a)pirena v zavisimosti ot rezhima naneseniia ego na kozhu mysheĭ.