Dental effects of Lycasin in the diet of laboratory rats.
Lycasin was included in diets fed to caries-active Osborne-Mendel rats for periods up to 8 weeks. The animals could tolerate up to 15-16% of Lycasin in dry-powder diets and up to 25% in pelleted diets before gastro-intestinal disturbance. Lycasin 80/55 at 25% in the diet was non-cariogenic, producing a very low level of caries, similar to that on a maize starch regimen and significantly below that on a sucrose regimen. At 16% in the diet D-sorbitol was even less cariogenic than Lycasin. Compared with the sucrose control, the reductions in caries scores were 89% on the sorbitol and 72% on the Lycasin 80/55 regimen.
Grenby
T H
TH
Department of Oral Medicine and Pathology, Guy's Hospital Dental School, London, UK.
D000818:Animals; D002327:Cariostatic Agents; D003731:Dental Caries / Q000209:etiology; D003773:Dental Plaque / Q000209:etiology; D004032:Diet; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013012:Sorbitol / Q000494:pharmacology; D013213:Starch / Q000494:pharmacology; D013395:Sucrose / Q000494:pharmacology; D013402:Sugar Alcohols / Q000494:pharmacology*; D013549:Sweetening Agents / Q000494:pharmacology*
D002327:Cariostatic Agents; D004040:Dietary Carbohydrates; D013402:Sugar Alcohols; D013549:Sweetening Agents; D013012:Sorbitol; D013395:Sucrose; D013213:Starch; C014646:Lycasin