Linearity of metoclopramide kinetics at doses of 5-20 mg.
The disposition of metoclopramide was studied on a four-way crossover basis in six healthy non-smoking volunteers. The linearity of kinetic parameters and absolute bioavailability of metoclopramide were examined. In contrast to previous reports, metoclopramide obeyed linear kinetics over oral doses ranging from 5 to 20 mg. The absolute bioavailability of metoclopramide was 0.76 +/- 0.38 (mean +/- s.d.) from the oral dosage forms examined in this study.
Wright
M R
MR
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Axelson
J E
JE
Rurak
D W
DW
McErlane
B
B
McMorland
G H
GH
Ongley
R C
RC
Tam
Y K
YK
Price
J D
JD
D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008787:Metoclopramide / Q000493:pharmacokinetics*
D008787:Metoclopramide