No detectable increase in sister chromatid exchanges in lymphocytes from mycosis fungoides patients after topical treatment with nitrogen mustard.
We measured sister chromatid exchanges (SCEs) in lymphocytes of eight MF patients before, and 2 h, and 24 h after treatment with topical nitrogen mustard. The mean number of SCEs/cell (+/- SEM) were 8.15 (+/- 0.62), 8.34 (+0.55) and 8.26 (+/- 0.56), respectively. The 2 h and 24 h results do not differ significantly from pretreatment levels. Our results show that concentrations of nitrogen mustard used to control MF do not induce SCEs in peripheral blood lymphocytes.
Studstrup
L
L
Department of Dermatology, University Hospital, Copenhagen, Denmark.
Beck
H I
HI
Bjerring
P
P
Wulf
H C
HC
Lundgren
K
K
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D008466:Mechlorethamine / Q000627:therapeutic use*; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy* / Q000235:genetics; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000235:genetics
D008466:Mechlorethamine