Some effects of the trypanocidal drug isometamidium on encapsulation in bovine carrier erythrocytes.
Bovine erythrocyte exposure to isometamidium chloride causes increased osmotic fragility. Control cells tolerated up to 1 mg/ml drug with no effects. Carrier erythrocytes were highly susceptible to drug, with increased osmotic fragility and decreased encapsulation potential of sucrose and inulin. Scanning electron micrographs of control and carrier erythrocytes exposed to drug revealed the formation of enkephalocytes with carrier erythrocytes. Control erythrocytes showed greater tolerance to the drug. Apparently, access of the drug to the interior of the erythrocyte membrane allows the drug to be more interactive with the membrane.
DeLoach
J R
JR
Veterinary Toxicology and Entomology Research Laboratory, U.S. Department of Agriculture, College Station, Texas 77841.
Wagner
G G
GG
D000818:Animals; D002417:Cattle; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D007444:Inulin / Q000097:blood; D008855:Microscopy, Electron, Scanning; D009996:Osmotic Fragility / Q000187:drug effects; D010617:Phenanthridines / Q000494:pharmacology*; D013395:Sucrose / Q000097:blood; D014344:Trypanocidal Agents / Q000494:pharmacology*
D010617:Phenanthridines; D014344:Trypanocidal Agents; D013395:Sucrose; C000702:isometamidium chloride; D007444:Inulin