Activity of calcium/phospholipid dependent protein kinase during rat kidney development.
The activity of the calcium sensitive phospholipid dependent protein kinase C (PKC) was studied in cytosol and in the proximal tubular luminal membrane of rats during growth. Cytosolic activity was elevated at 14 and 21 days of age and fell to adult levels by day 60. Luminal brush border membrane activity on the other hand was low on day 14 but reached adult levels by day 21. Changes in brush border membrane PKC activity may have important consequences for the development of electrolyte transport in proximal tubular cells.
Hise
M K
MK
Division of Nephrology, University of Maryland, Baltimore 21201.
Mehta
P
P
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000502:physiology; D003600:Cytosol / Q000201:enzymology; D007668:Kidney / Q000196:embryology / Q000201:enzymology*; D007672:Kidney Cortex / Q000196:embryology / Q000201:enzymology; D007687:Kidney Tubules, Proximal / Q000196:embryology / Q000201:enzymology; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D008297:Male; D008566:Membranes / Q000196:embryology / Q000201:enzymology; D009955:Ornithine Decarboxylase / Q000378:metabolism; D010743:Phospholipids / Q000502:physiology; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D010743:Phospholipids; D011493:Protein Kinase C; D000469:Alkaline Phosphatase; D007931:Leucyl Aminopeptidase; D009955:Ornithine Decarboxylase; D002118:Calcium