Structure of the mouse C-reactive protein gene.
A genomic DNA clone corresponding to the mouse C-reactive protein (CRP) has been isolated and characterized. The mouse CRP gene is 1.9-kilobase pairs in length and contains a single intron of 213-base pairs which interrupts the codon for the 2nd amino acid residue of the mature CRP protein. We compared nucleotide sequences of the mouse and human CRP genes and discussed structures of possible regulatory sequences. With this characterization, the isolation and sequence analyses of a set of mouse and human pentraxin genes, i.e. CRP and serum amyloid P component genes is not complete.
Ohnishi
S
S
Department of Biochemistry, Kumamoto University Medical School, Japan.
Maeda
S
S
Nishiguchi
S
S
Arao
T
T
Shimada
K
K
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002097:C-Reactive Protein / Q000235:genetics*; D003062:Codon; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D015246:Deoxyribonuclease EcoRI; D015247:Deoxyribonuclease HindIII; D005091:Exons; D006801:Humans; D007438:Introns; D008099:Liver / Q000032:analysis; D051379:Mice; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D012045:Regulatory Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid
D003062:Codon; D015342:DNA Probes; D002097:C-Reactive Protein; D004247:DNA; D015246:Deoxyribonuclease EcoRI; D015247:Deoxyribonuclease HindIII