title: [Experimental and clinical study of the effectiveness of the combined use of anticonvulsants and tranquilizers in epilepsy].
abstract: Using experimental and clinical methods, the authors studied the efficacy of combined use of anticonvulsants (phenobarbital, hexamidine, chloracon, trimetin, benzonal, diphenylhydantoin, carbamazepine) and tranquilizers (diazepam, chlordiazepoxide, meprotan, trioxazine, mebicar) in epilepsy treatment. The experimental findings showed that 13 combinations of the above drugs had a synergic effect. Five of these combinations (hexamidine-chlordiazepoxide, benzonal-chlordiazepoxide, phenobarbital-diazepam, phenobarbital-trioxazine, and phenobarbital-mebicar also proved clinically more effective than the use of anticonvulsants alone.
authors.forename: V S
authors.initials: VS
authors.lastname: Zalesov
authors.forename: T I
authors.initials: TI
authors.lastname: Prostakova
authors.forename: E A
authors.initials: EA
authors.lastname: Khvolis
authors.forename: A A
authors.initials: AA
authors.lastname: Shutov
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use* / Q000633:toxicity; D004285:Dogs; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D051381:Rats; D012640:Seizures / Q000188:drug therapy; D014149:Tranquilizing Agents / Q000627:therapeutic use* / Q000633:toxicity
chemical_list: D000925:Anticoagulants; D014149:Tranquilizing Agents
vernacular_title: Eksperimental'noe i klinicheskoe izuchenie éffektivnosti kombinirovannogo primeneniia antikonvul'santov i trankvilizatorov pri épilepsii.