title: In vitro culture of Echinococcus multilocularis: protoscolicidal action of praziquantel and albendazole sulphoxide.
abstract: The metacestode stage of Echinococcus multilocularis was cultured in vitro. Sensitivity of protoscoleces to the presence of albendazole sulphoxide, praziquantel and methanol was assessed. 10 micrograms/litre of praziquantel or 500 micrograms/litre of albendazole sulphoxide significantly reduced protoscolex viability. The presence of methanol (at 0.25%) had no significant effect. In vitro culture of E. multilocularis can be used to assess possible chemotherapeutic agents.
authors.affiliation: Department of Surgery, University Hospital, Queen's Medical Centre, Nottingham, UK.
authors.forename: D H
authors.initials: DH
authors.lastname: Taylor
authors.forename: D L
authors.initials: DL
authors.lastname: Morris
mesh_terms: D015766:Albendazole / Q000031:analogs & derivatives*; D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D004443:Echinococcosis / Q000188:drug therapy*; D066298:In Vitro Techniques; D010274:Parasitology / Q000379:methods*; D011223:Praziquantel / Q000627:therapeutic use*; D051381:Rats
chemical_list: D001562:Benzimidazoles; D011223:Praziquantel; D015766:Albendazole; C027186:albendazole sulfoxide