Antifertility effect in male rats of oleanolic acid, a triterpene from Eugenia jambolana flowers.
The antifertility activity of oleanolic acid (C30H48O3), isolated from the flowers of Eugenia jambolana, was evaluated in male albino rats. The administration of the compound for 60 days decreased the fertilizing capacity of the animals without any significant changes in body weight or reproductive organ weights. The compound produced arrest of spermatogenesis but did not cause any abnormality to spermatogenic cells, Leydig interstitial cells and Sertoli cells. Oleanolic acid may prove to be a promising antifertility agent devoid of undesirable side effects.
Rajasekaran
M
M
Department of Pharmacology, Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Bapna
J S
JS
Lakshmanan
S
S
Ramachandran Nair
A G
AG
Veliath
A J
AJ
Panchanadam
M
M
D000818:Animals; D003272:Contraceptive Agents, Male; D008297:Male; D009828:Oleanolic Acid / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D012502:Sapogenins / Q000494:pharmacology*; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects
D003272:Contraceptive Agents, Male; D012502:Sapogenins; D009828:Oleanolic Acid