Use of xylazine sedation with yohimbine antagonism in captive gray wolves.
Captive gray wolves (Canis lupus) were given 2.2 mg/kg xylazine hydrochloride intramuscularly resulting in profound sedation in 9.1 +/- 0.6 min (mean +/- SE). Heart rate was 42.0 +/- 1.0 beats per minute and respiratory rate was 20.1 +/- 1.6 respirations per minute during sedation. A variety of manipulations could be performed on sedated animals in relative safety. Thirty min after xylazine administration, the animals were given either 0.15 mg/kg yohimbine hydrochloride or 5% dextrose solution intravenously causing recovery in 5.3 +/- 1.0 and 97.1 +/- 14.0 min, respectively (P less than 0.001).
Kreeger
T J
TJ
Department of Fisheries and Wildlife, University of Minnesota, St. Paul 55108.
Seal
U S
US
Callahan
M
M
Beckel
M
M
D000822:Animal Husbandry; D000818:Animals; D002335:Carnivora; D005260:Female; D006993:Hypnotics and Sedatives / Q000037:antagonists & inhibitors; D007103:Immobilization; D008297:Male; D013843:Thiazines / Q000494:pharmacology*; D014991:Xylazine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D015016:Yohimbine / Q000494:pharmacology*
D006993:Hypnotics and Sedatives; D013843:Thiazines; D014991:Xylazine; D015016:Yohimbine