Mutagenicity testing of vincristine sulfate in germ cells of male mice.
Vincristine sulfate (VCR) affects the fertilization ability of all germ-cell stages in male mice. The reduced fertilization ability leads to a pseudo-dominant-lethal effect and sterile matings. The frequency of these effects is dose-dependent. The frequency of specific-locus mutations was not increased by VCR in male mice following 2 mg/kg bw treatment.
Ehling
U H
UH
Institut für Säugetiergenetik, Gesellschaft für Strahlen- und Umweltforschung (GSF), Neuherberg, F.R.G.
Kratochvilova
J
J
Lehmacher
W
W
Neuhäuser-Klaus
A
A
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005306:Fertilization / Q000187:drug effects; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D013094:Spermatozoa / Q000187:drug effects*; D014750:Vincristine / Q000494:pharmacology*
D014750:Vincristine