Transfer of benzo(a)pyrene into mouse embryos and fetuses.
The distribution of radioactive material within maternal and embryonic/fetal mouse tissue was studied over a period of 2 days following a single dose of 14C-benzo(a)pyrene (B(a)P) orally on days 11, 12, 13 or 18 of pregnancy. B(a)P poorly penetrated into the embryo/fetus, and 14C-radioactivity was found in embryonic tissues at concentrations one to two orders of magnitude lower than in maternal organs. If the compound was administered for 3 consecutive days at the same dose the expected cumulation was compensated for by an accelerated elimination of the substance, which is probably due to enzyme induction.
Neubert
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Institut für Toxikologie und Embryopharmakologie, Freie Universität Berlin.
Tapken
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D000818:Animals; D001564:Benzo(a)pyrene / Q000493:pharmacokinetics*; D004622:Embryo, Mammalian / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D051379:Mice; D011247:Pregnancy; D014018:Tissue Distribution
D001564:Benzo(a)pyrene