Studies on zinc sulphate microcapsules (2): Application of factorial design.
In this study a 2(3) factorial design has been applied to the evaluation of dissolution characteristics of zinc sulphate microcapsules. The kinetic model according to the Rosin-Rimmler-Sperling-Bennet-Weillbull (RRSBW) distribution was applied for the parametric representation of the dissolution curves. The effect of three factors; core: wall ratio, amount of zinc sulphate and particle size of the microcapsules, on the dissolution rate of zinc sulphate were studied at two levels. The factorial design method proved to be useful for the examination of microcapsules.
Oner
L
L
University of Hacettepe, Faculty of Pharmacy, Pharmaceutical Technology Department, Ankara, Turkey.
Kaş
H S
HS
Hincal
A A
AA
D002214:Capsules; D002482:Cellulose / Q000031:analogs & derivatives; D008958:Models, Molecular; D012995:Solubility; D013431:Sulfates / Q000493:pharmacokinetics*; D015032:Zinc / Q000493:pharmacokinetics*; D019287:Zinc Sulfate
D002214:Capsules; D013431:Sulfates; D019287:Zinc Sulfate; C013517:ethyl cellulose; D002482:Cellulose; D015032:Zinc