title: Absence of detectable chromosomal and molecular abnormalities in monozygotic twins discordant for the Wiedemann-Beckwith syndrome.
abstract: Monozygotic twins discordant for the Wiedemann-Beckwith syndrome (WBS) were studied by cytogenetic and molecular methods to determine if a genetic lesion could be detected in the affected child. Probes known to be localized on the short arm of chromosome 11 and a low copy-repetitive probe were used. No genetic lesions could be ascertained in normal or affected tissue obtained from the WBS twin.
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis.
authors.forename: C E
authors.initials: CE
authors.lastname: Litz
authors.forename: K A
authors.initials: KA
authors.lastname: Taylor
authors.forename: J S
authors.initials: JS
authors.lastname: Qiu
authors.forename: O H
authors.initials: OH
authors.lastname: Pescovitz
authors.forename: B
authors.initials: B
authors.lastname: de Martinville
mesh_terms: D001506:Beckwith-Wiedemann Syndrome / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D015342:DNA Probes; D004200:Diseases in Twins; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007223:Infant; D010641:Phenotype; D014430:Twins, Monozygotic
chemical_list: D015342:DNA Probes; D005819:Genetic Markers