title: Suppression by mepyramine maleate of the increased vascular permeability in passive cutaneous anaphylaxis in the chicken.
abstract: Passive cutaneous anaphylaxis was produced in chickens pretreated with the antihistamine mepyramine maleate. Quantitative estimation of the increased vascular permeability in the lesion revealed 79.5% suppression indicating its mediation largely by histamine. The findings suggest that the quantitative estimation of the increased vascular permeability, though time-consuming, is more precise than the visual assessment.
authors.affiliation: Department of Pathology, College of Veterinary Science & Animal Husbandry, Jabalpur, India.
authors.forename: A G
authors.initials: AG
authors.lastname: Pillai
authors.forename: R P
authors.initials: RP
authors.lastname: Awadhiya
authors.forename: J L
authors.initials: JL
authors.lastname: Vegad
mesh_terms: D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D002645:Chickens / Q000276:immunology / Q000502:physiology*; D005260:Female; D008297:Male; D010323:Passive Cutaneous Anaphylaxis; D011738:Pyrilamine / Q000494:pharmacology*
chemical_list: D000631:Aminopyridines; D011738:Pyrilamine