title: Morning-evening changes in airway responsiveness to methacholine in normal and asthmatic subjects: analysis using partial flow-volume curves.
abstract: In eight normal and eight asthmatic subjects airway responsiveness to methacholine was measured by means of partial flow-volume loops at 0800 and 1800 hours on the same day. Airway responsiveness was lower in the evening in both normal and asthmatic subjects.
authors.affiliation: Department of Medicine, Charing Cross and Westminster Medical School, London.
authors.forename: R W
authors.initials: RW
authors.lastname: Heaton
authors.forename: M K
authors.initials: MK
authors.lastname: Gillett
authors.forename: P D
authors.initials: PD
authors.lastname: Snashall
mesh_terms: D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D001249:Asthma / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D002794:Choline / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014797:Vital Capacity
chemical_list: C017506:methylcholine; D002794:Choline