Preliminary studies of the effects of a Peruvian snake Bothrops pictus (jergon of the coast) venom upon fibrinogen.
Bothrops pictus (jergon of the coast) venom has a coagulant effect in vitro on both canine fibrinogen and on human and canine plasma, with a greater affinity for canine plasma. In vivo a single dose of venom produced partial defibrinogenation in conscious dogs, plasma fibrinogen being reduced to about 60% of control values after 6 hr.
Olascoaga
M E
ME
Departamento de Biología, Facultad de Ciencias, Universidad Nacional Agraria La Molina, Lima, Perú.
Zavaleta
A
A
Marsh
N A
NA
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D003435:Crotalid Venoms / Q000633:toxicity*; D004285:Dogs; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques
D003435:Crotalid Venoms; D005340:Fibrinogen