[Effect of gamma-aminobutyric acid and its agonists on uterine contractile activity].
In chronic experiments on female rabbits it was shown that GABA-receptor agonist phenibut given in small doses exerts the stimulating effect, while GABA and phenibut administered in large doses suppress the uterine contractile activity, acting probably as modulators of presynaptic release of neuromediators. Diazepam displays the regulatory effect on the uterine contractions via the postsynaptic receptor mechanisms. The data suggest the involvement of the GABAergic mechanisms in the uterine contractile function.
Sizov
P I
PI
Iasnetsov
V S
VS
D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D011817:Rabbits; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology
D005680:gamma-Aminobutyric Acid; D003975:Diazepam; C008842:4-amino-3-phenylbutyric acid
Vliianie gamma-aminomaslianoĭ kisloty i ee agonistov na sokratitel'nuiu aktivnosti matki.