Estradiol-produced modifications on the response to glucose of hepatocytes from fasted rats.
Estradiol treatment modified the metabolic responses of fasted rat hepatocytes to exogenous glucose with respect to glucose utilization and cytosolic NADPH-generating enzymes. The estrogen abolished the glucose-stimulated gluconeogenic capacity displayed by control rat cells while promoting a net uptake of exogenous glucose and enhancing the glucose-6-phosphate dehydrogenase activity. Estradiol also caused an increase in the activity of the isocitrate dehydrogenase that may be related to the enhanced needs of NADPH by hepatocytes for steroid hormone catabolism.
Astiazaran
A M
AM
Department of Physiology, Faculty of Medicine, University of the Basque Country, Bilbao, Spain.
Ochoa
B
B
Lacort
M
M
D000818:Animals; D003600:Cytosol / Q000201:enzymology; D004958:Estradiol / Q000494:pharmacology*; D005215:Fasting; D005260:Female; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology*; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D007773:Lactates; D011773:Pyruvates; D004958:Estradiol; D005947:Glucose