Objective measurement of surfactant irritation by fiber optic spectroscopy.
Erythema caused by occlusion of 3 concentrations of surfactant was quantified in vivo using a modified spectrophotometer. Standard chamber irritation test sites were evaluated objectively using the spectrophotometer and subjectively by trained observers. There was a good relationship between the instrumental and visual evaluations. The spectrum was analyzed and a region was chosen to optimize the sensitivity of the method.
Crowe
D M
DM
Department of New Science and Technology, Dial Technical Center, Scottsdale, AZ 85254.
Willard
M S
MS
Murahata
R I
RI
Aust
L B
LB
Gacula
M C
MC
D000328:Adult; D000368:Aged; D003877:Dermatitis, Contact / Q000473:pathology*; D004890:Erythema / Q000473:pathology*; D005260:Female; D005336:Fiber Optic Technology; D006801:Humans; D007509:Irritants / Q000009:adverse effects; D008875:Middle Aged; D055100:Optical Fibers; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects; D013053:Spectrophotometry / Q000295:instrumentation / Q000379:methods*; D013501:Surface-Active Agents / Q000009:adverse effects
D007509:Irritants; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate