The structure of the human glutathione S-transferase pi gene.
The human glutathione S-transferase pi gene has been isolated from a cosmid library. The gene spans approximately 3 kb, is interrupted by six introns and the region around its 5' end has the high G + C and CpG content typical of an HTF (HpaII tiny fragment) island. In addition to a TATA box at position -28 relative to the transcription initiation site and two G + C boxes (GGGCGG), the promoter contains a sequence motif matching the phorbol ester- and ras-responsive element from the polyoma virus enhancer.
Cowell
I G
IG
Cancer Research Campaign Molecular Toxicology Research Group, University College and Middlesex School of Medicine, London, U.K.
Dixon
K H
KH
Pemble
S E
SE
Ketterer
B
B
Taylor
J B
JB
D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D015139:Blotting, Southern; D003001:Cloning, Molecular; D005796:Genes; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
D007527:Isoenzymes; D005982:Glutathione Transferase