[Morphogenesis of peripheral cancer of the lung].
Principal stages in morphogenesis of peripheral lung cancer (PLC) were studied on operative specimens obtained from 200 PLC patients with majority tumors 0.5-3 cm in diameter. PLC was found to involve predominantly sites of preexisting cicatrices available in 93.1% of cases of small cancer. Essential in PLC onset may be Ghon's, Simon's and Aschoff-Pool focus cicatrices and tuberculomas recorded in 113 patients (70%). Pneumoconiosis- induced and postpneumonic cicatrices occurred in 42 (26%) and 6 (4%) patients, respectively. Dysplasia of small bronchi epithelium, bronchioles and alveoli found in cicatrices should be considered PLC precancer. The authors hold that cicatricial lesions in lung periphery are PLC risk factors.
Kogan
E A
EA
Kodolova
I M
IM
Sekamova
S M
SM
D000328:Adult; D000368:Aged; D002921:Cicatrix / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011009:Pneumoconiosis / Q000150:complications; D011014:Pneumonia / Q000150:complications; D011230:Precancerous Conditions / Q000473:pathology*; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000150:complications
Morfogenez perifericheskogo raka legkogo.