Absence of a gamma-melanocyte-stimulating hormone sequence in proopiomelanocortin mRNA of chum salmon Oncorhynchus keta.
1. Complete nucleotide sequence of one of the salmon proopiomelanocortin mRNAs (POMC mRNAs) was determined. 2. The region corresponding to gamma-melanocyte-stimulating hormone (gamma-MSH) was lacking in salmon POMC mRNA, although overall organization of the multi-hormone structure was exactly the same as that of mammalian POMC mRNAs. 3. The possible evolutional history of POMC mRNA in mammalian species may be revealed from the finding of this characteristic that salmon POMC mRNA lacks the region corresponding to gamma-MSH.
Kitahara
N
N
Biotechnology Research Center, Teikyo University, Kanagawa, Japan.
Nishizawa
T
T
Iida
K
K
Okazaki
H
H
Andoh
T
T
Soma
G I
GI
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D009074:Melanocyte-Stimulating Hormones / Q000235:genetics*; D008969:Molecular Sequence Data; D011333:Pro-Opiomelanocortin / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D012474:Salmon / Q000235:genetics*
D012333:RNA, Messenger; D011333:Pro-Opiomelanocortin; D009074:Melanocyte-Stimulating Hormones