title: [Carcinogenic effect of benz(a)pyrene depending on its mode of application to the skin of mice].
abstract: The role of dose and time factors in intensification of the carcinogenic effect is studied on the model of skin carcinogenesis in (CBA x C57Bl)F1 female mice under application of BP. The total dose is not a single parameter determining the carcinogenic effect. The single dose interval between the actions and their number are of essential importance under definite conditions. The total time (T) of the carcinogen action is a significant factor. The total and single doses and the number of carcinogen applications to the mouse skin being similar, the effect is the stronger, the longer is T, i.e. the longer is the interval between certain applications of the carcinogen.
authors.forename: G Kh
authors.initials: GKh
authors.lastname: Kosoĭ
authors.forename: Iu D
authors.initials: IuD
authors.lastname: Parfenov
authors.forename: V S
authors.initials: VS
authors.lastname: Turusov
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001564:Benzo(a)pyrene / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012867:Skin / Q000187:drug effects*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D013997:Time Factors
chemical_list: D001564:Benzo(a)pyrene
vernacular_title: Kantserogennyĭ éffekt benz(a)pirena v zavisimosti ot rezhima naneseniia ego na kozhu mysheĭ.