Removal of surgically induced fibrous arterial plaques by argon ion laser angiosurgery using a multifiber delivery system. An experimental study in the dog.
Removal of intravascular atherosclerotic obstructions by laser irradiation has gained the attention of many investigators, but has proven to be considerably more difficult to accomplish than initially envisioned. We tested, in an animal model, an argon ion laser delivery system that permits control of (1) laser power, (2) exposure time, and (3) laser beam spot size. The study was conducted on surgically, induced focal fibrous plaques in the carotid arteries of nine dogs. Plaque removal, vessel patency, and healing were evaluated angiographically and by light and electron microscopy at intervals up to 60 days after treatment. Results showed that intravascular obstructions could be removed, healing occurred, and vessels remained patent for up to 60 days.
Kjellström
B T
BT
Research Institute, Cleveland Clinic Foundation, Ohio.
Bylock
A L
AL
Bott-Silverman
C
C
Engelmann
G L
GL
Gerrity
R G
RG
Kittrell
C
C
Cothren
R M
RM
Hayes
G B
GB
Feld
M S
MS
Kramer
J R
JR
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000473:pathology / Q000601:surgery*; D001161:Arteriosclerosis / Q000601:surgery; D002340:Carotid Artery Diseases / Q000473:pathology / Q000601:surgery; D004195:Disease Models, Animal; D004285:Dogs; D004730:Endothelium, Vascular / Q000648:ultrastructure; D005500:Follow-Up Studies; D007365:Intercellular Junctions / Q000648:ultrastructure; D053685:Laser Therapy