Examination of parameters determining particle size distribution: acetylsalicylic acid microcapsules.
A method of preparation of acetylsalicylic acid microcapsules has been elaborated. The active ingredient was made suitable for microencapsulation by recrystallization before phase separation coating. Experiments were performed on the basis of factorial design, and parameters which influence the particle size and particle size distribution of microcapsules were characterized quantitatively.
Dévay
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Pharmaceutical Institute, Semmelweis Medical University, Budapest, Hungary.
Rácz
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D001241:Aspirin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002214:Capsules; D002482:Cellulose / Q000031:analogs & derivatives; D003460:Crystallization; D010316:Particle Size
D002214:Capsules; C013517:ethyl cellulose; D002482:Cellulose; D001241:Aspirin