Cardiotoxic manifestations of mesoridazine overdose.
We present a case of malignant arrhythmias associated with hypocalcemia and subsequent cardiac arrest in a 20-year-old woman due to ingestion of 3.1 g mesoridazine in a suicide attempt. There were unexplained alterations in serum electrolytes preceding the cardiac arrest. The patient subsequently recovered and was transferred to a psychiatric hospital. Despite the paucity of data on the potential cardiotoxicity associated with mesoridazine overdose, this case demonstrates that malignant arrhythmias and cardiac arrest occur; consequently, these patients probably require constant ECG monitoring.
Marrs-Simon
P A
PA
Department of Pharmacy Practice, College of Pharmacy, University of Illinois, Chicago 60612.
Zell-Kanter
M
M
Kendzierski
D L
DL
Leikin
J B
JB
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D004562:Electrocardiography; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D008653:Mesoridazine / Q000506:poisoning*; D013406:Suicide, Attempted
D008653:Mesoridazine