title: Cardiopulmonary effects of a halothane/oxygen combination in hypovolemic cats.
abstract: The cardiopulmonary effects of a halothane/oxygen combination were studied in eight cats subjected to a 25% whole blood volume loss. Test parameters included cardiac output measured via thermodilution, heart rate, respiratory rate, arterial blood pressure (systolic, diastolic and mean) and blood gas analysis. Values for cardiac index, stroke volume and systemic vascular resistance were calculated from these data. Posthemorrhage cardiac output, cardiac index, stroke volume and measurements of arterial blood pressure were significantly decreased (p less than 0.05). Heart rate remained unchanged. Following induction of halothane anesthesia the above parameters experienced a further significant decline (p less than 0.05) from their immediate preanesthetic (i.e. posthemorrhage) values. Heart rate also significantly decreased (p less than 0.05). Thirty minutes following the cessation of halothane anesthesia these values returned to near-hemorrhage levels, being above their respective preanesthetic values. Systemic vascular resistance initially rose, peaking ten minutes into halothane anesthesia, before gradually falling to prehemorrhage values at the end of halothane anesthesia. Following hemorrhage, respiratory rate demonstrated a transient increase, associated with an arterial CO2 tension fall, before returning to initial values at the preanesthetic time. During halothane anesthesia respiratory rate remained unchanged whereas arterial CO2 tension rose significantly (p less than 0.05) and pH declined slightly from preanesthetic readings. These returned to prehemorrhage values 30 minutes following the cessation of halothane anesthesia.
authors.affiliation: Department of Clinical Studies, Ontario Veterinary College, University of Guelph.
authors.forename: W
authors.initials: W
authors.lastname: Ingwersen
authors.forename: D G
authors.initials: DG
authors.lastname: Allen
authors.forename: D H
authors.initials: DH
authors.lastname: Dyson
authors.forename: W D
authors.initials: WD
authors.lastname: Black
authors.forename: M T
authors.initials: MT
authors.lastname: Goldberg
authors.forename: A E
authors.initials: AE
authors.lastname: Valliant
mesh_terms: D000769:Anesthesia, Inhalation / Q000662:veterinary*; D000818:Animals; D001810:Blood Volume; D002415:Cats / Q000502:physiology*; D004338:Drug Combinations; D005260:Female; D006221:Halothane / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006470:Hemorrhage / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D010100:Oxygen / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*
chemical_list: D004338:Drug Combinations; D010100:Oxygen; D006221:Halothane