[Effect of the beta-blocker propranolol (obzidan) on the content of macroergic phosphates and the development of the size of necrotic areas in the myocardium in experimental acute coronary occlusion].
Coronary arterial occlusion, maintained for 7 days in rabbits was accompanied by a marked and fairly stable drop in macroergic phosphates (ATP, creatine phosphate), seen in the perinecrotic and distant left and right ventricular myocardium. The administration of 0.5 mg/kg propranolol twice daily within 30-40 min after coronary arterial ligation resulted in a significant increase in ATP and the adenine nucleotides pool at a distance from the necrotic focus in the right and left ventricular myocardium on treatment days 3 and 7 and did not affect the recovery of normal creatine phosphate in the same myocardial areas. Propranolol treatment limited progressive death of myocardial cell population, reducing by 37% myocardial infarction size by day 7 of the experimental study, as compared to the situation in the untreated animals.
Irgashev
Sh B
ShB
Mavridi
D I
DI
Iuldashev
N M
NM
D000208:Acute Disease; D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009336:Necrosis; D010710:Phosphates / Q000378:metabolism*; D011433:Propranolol / Q000627:therapeutic use*; D011817:Rabbits; D013997:Time Factors
D010710:Phosphates; D011433:Propranolol
Vliianie beta-blokatora propranolola (obzidana) na soderzhanie makroérgicheskikh fosfatov i formirovanie razmerov zon nekroza v miokarde pri ostroĭ koronarnoĭ okkliuzii v éksperimente.