Biocompatibility studies with a novel perfluorochemical emulsion.
Biocompatibility studies with a novel perfluorochemical (PFC) emulsion have been performed in rats. Injection of the emulsion was followed by changes in lymphoid tissue weights, comparable but not identical to those produced by the commercial formulation, Fluosol-DA 20% (F-DA). Peritoneal injection of either the novel emulsion or F-DA enhanced the humoral immune response to intraperitoneally-injected sheep red blood cells (SRBC) suggesting immunopotentiating properties of emulsion components.
Bollands
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Department of Zoology, University of Nottingham, U.K.
Lowe
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KC
Sharma
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SK
Davis
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SS
D000818:Animals; D000906:Antibodies / Q000032:analysis; D001802:Blood Substitutes; D004338:Drug Combinations / Q000494:pharmacology; D004655:Emulsions; D005260:Female; D005449:Fluorenes / Q000276:immunology; D005466:Fluorocarbons / Q000276:immunology / Q000494:pharmacology; D006895:Hydroxyethyl Starch Derivatives; D007114:Immunization; D008099:Liver / Q000033:anatomy & histology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000906:Antibodies; D001802:Blood Substitutes; D004338:Drug Combinations; D004655:Emulsions; D005449:Fluorenes; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C008805:perfluorodecalin; C057575:perfluoroperhydrofluoranthene; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination