Granulocytic sarcoma of the small intestine preceding acute myelomonocytic leukemia with abnormal eosinophils and inv(16).
We report a case of preleukemic granulocytic sarcoma of the small intestine preceding the development of acute myelomonocytic leukemia with abnormal eosinophils and inversion of chromosome 16, inv(16)(p13q22). A literature review suggests that this is a recurring cytogenetic-clinicopathologic association and carries a favorable prognosis, especially if treated aggressively with antileukemic therapy at the time of diagnosis.
Russell
S J
SJ
Department of Cell and Molecular Biology, Royal Cancer Hospital, Chester Beatty Laboratories, London, England.
Giles
F J
FJ
Thompson
D S
DS
Scanlon
D J
DJ
Walker
H
H
Richards
J D
JD
D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D004804:Eosinophils / Q000473:pathology*; D006801:Humans; D007414:Intestinal Neoplasms / Q000235:genetics* / Q000473:pathology; D007421:Intestine, Small; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged