title: Class-specific antibody response to pneumococcal capsular polysaccharides in men infected with human immunodeficiency virus type 1.
abstract: We characterized the effect of infection with human immunodeficiency virus type 1 (HIV) on levels of total immunoglobulins and pneumococcal vaccine-specific immunoglobulins in 28 heterosexual and 25 homosexual men seronegative for HIV; 27 asymptomatic, seropositive homosexual men; and 21 patients with AIDS. Total serum IgG levels were increased in both HIV-seropositive groups compared with the HIV-seronegative men (P less than .001). Total IgM levels, however, were elevated only in the asymptomatic, HIV-seropositive men (P less than .08); total IgA levels were elevated only in the patients with AIDS (P less than .05). Vaccine-specific serum IgG, IgM, and IgA significantly increased over baseline three and six weeks after immunization in all groups (P less than .05). Responses to vaccine among the HIV-seronegative groups were similar but were greater for all antibody classes than were responses among the HIV-seropositive groups (P less than .05).
authors.affiliation: Infectious Disease Section, Veterans Administration Medical Center, Minneapolis, Minnesota 55417.
authors.forename: E N
authors.initials: EN
authors.lastname: Janoff
authors.forename: J M
authors.initials: JM
authors.lastname: Douglas
authors.forename: M
authors.initials: M
authors.lastname: Gabriel
authors.forename: M J
authors.initials: MJ
authors.lastname: Blaser
authors.forename: A J
authors.initials: AJ
authors.lastname: Davidson
authors.forename: D L
authors.initials: DL
authors.lastname: Cohn
authors.forename: F N
authors.initials: FN
authors.lastname: Judson
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001428:Bacterial Vaccines / Q000276:immunology*; D006679:HIV Seropositivity; D015497:HIV-1 / Q000276:immunology; D006716:Homosexuality; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007136:Immunoglobulins / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D022242:Pneumococcal Vaccines; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D022242:Pneumococcal Vaccines