Remarkable response of lipoid proteinosis to oral dimethyl sulphoxide.
We report the successful treatment of lipoid proteinosis in a 41-year-old man using oral dimethyl sulphoxide. The initial dosage was 40 mg/kg/day, which was then increased progressively to 60 mg/kg/day. After 3 years of treatment, the patient's skin lesions, hoarseness of voice and abnormal oesophageal function improved remarkably. No side-effects were noted except for a garlic-like smell on the patient's breath.
Wong
C K
CK
Department of Dermatology, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China.
Lin
C S
CS
D000284:Administration, Oral; D000328:Adult; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008064:Lipidoses / Q000188:drug therapy*; D008065:Lipoid Proteinosis of Urbach and Wiethe / Q000188:drug therapy*; D008297:Male
D004121:Dimethyl Sulfoxide