In vivo solute extraction by a new polysulphone membrane with low ultrafiltration capacity.
High flux polysulphone (PS600, Fresenius) is a highly biocompatible membrane, but the high ultrafiltration (UF) capacity limits its clinical applications. In the present study a new PS (PS400) with an UF coefficient in the range of cuprophan (CU) but a biocompatibility like high flux PS was evaluated. Dialysis efficiency with PS400 was compared to dialyzers with the same surface, at similar blood flows. Overall extraction of UV-absorbing compounds was higher with PS400 (P less than 0.01). The extraction of the individual compounds, hippuric acid and parahydroxy-hippuric acid was also higher for PS400 (P less than 0.01 resp. less than 0.05). The fall in white blood cells after 15 min. of dialysis was from 6.5 +/- 1.5 to 1.7 +/- 0.6 for CU (-83%), and from 8.6 +/- 1.7 to only 7.4 +/- 1.7 x 10(3) cells/mm3 (-14%) for PS400 (P less than 0.01 versus CU). Ultrafiltration characteristics were similar for both dialyzers.
Vanholder
R
R
Nephrology Department, University Hospital, Ghent, Belgium.
Krause
A
A
De Smet
R
R
Ringoir
S
S
D001672:Biocompatible Materials; D001794:Blood Pressure; D002851:Chromatography, High Pressure Liquid; D006626:Hippurates / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count; D008567:Membranes, Artificial; D011108:Polymers; D006435:Renal Dialysis / Q000295:instrumentation*; D013450:Sulfones; D014462:Ultrafiltration; D014508:Urea / Q000032:analysis
D001672:Biocompatible Materials; D006626:Hippurates; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; D014508:Urea; C030514:hippuric acid