title: [Oxygen--concentration and acid-base status of arterial blood as limiting factors in hemodilution].
abstract: Normovolemic hemodilution under normoxic conditions (arterial oxygen partial pressure normal) at rest is limited by the critical arterial oxygen content of about 6 ml/dl corresponding to a hemoglobin concentration of 4.4 g/dl. This critical oxygen content is derived from the arteriovenous oxygen difference of the myocardium, assumed that the coronary blood flow is increased by 100% and the available oxygen is utilized nearly totally. Furthermore, extreme hemodilution leads to a dilution acidosis when bicarbonate free solutions are used for hemodilution. This acidosis may decrease both peripheral resistance and mean arterial blood pressure.
authors.affiliation: Physiologisches Institut der Universität Mainz.
authors.forename: R
authors.initials: R
authors.lastname: Zander
mesh_terms: D000136:Acid-Base Equilibrium; D001639:Bicarbonates / Q000097:blood; D001810:Blood Volume; D006438:Hemodilution / Q000379:methods*; D006452:Hemoglobinometry; D006801:Humans; D010100:Oxygen / Q000097:blood*
chemical_list: D001639:Bicarbonates; D010100:Oxygen
vernacular_title: Sauerstoff--Konzentration und Säure-Basen-Status des arteriellen Blutes als limitierende Faktoren einer Hämodilution.