Carotene intake and the risk of laryngeal cancer in coastal Texas.
Between 1976 and 1980, data were collected for a case-comparison study of laryngeal cancer in white males aged 30-79 years in six Texas counties using all histologically confirmed incident cases and a population-based comparison group. Dietary interviews were obtained from 151 living cases and 178 living comparison subjects. A significant inverse association (odds ratio (OR) = 2.1) was found between low carotene intake and the risk of laryngeal cancer, but no association was found with total vitamin A or retinol intake. The inverse association with carotene intake was strongest among those who had stopped smoking 2-10 years before (OR = 5.9). The same risk for vitamin A intake was found by using a short list of foods based on contribution to variation in intake as was found by using a longer list based on per cent contribution to total intake. Definition of carotene as that which comes only from plant sources gives an estimate similar to a more complex method that takes into account carotene derived from both plant and animal sources.
Mackerras
D
D
School of Public Health, University of Texas Health Science Center, Houston 77225.
Buffler
P A
PA
Randall
D E
DE
Nichaman
M Z
MZ
Pickle
L W
LW
Mason
T J
TJ
D000328:Adult; D000368:Aged; D002338:Carotenoids / Q000008:administration & dosage*; D004034:Diet Surveys; D004435:Eating; D006801:Humans; D007822:Laryngeal Neoplasms / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013781:Texas; D014801:Vitamin A / Q000008:administration & dosage
D014801:Vitamin A; D002338:Carotenoids