[Immunocorrecting properties and effect on the phosphorus-calcium metabolism of oxidevit (1 alpha-hydroxyvitamin D3)].
Effect of oxidevite (I alpha-hydroxyvitamin D3) on the patterns of immunity system and metabolism of calcium and phosphorus were studied in 45 patients with chronic bronchitis, which, were treated with the drug at doses of 2 or 4 micrograms during 1 or 2 weeks. Specific patterns of calcium and phosphorus metabolism were altered in the patients depending on dose of the drug and duration of the course treatment. The dose of 4 micrograms per a day within 2 weeks was excessive. All the immunity patterns studied involving amount of total and rosette-forming cells, T-lymphocyte helpers and T-lymphocyte suppressors, B lymphocytes, were normalized independently on the initial level of these patterns: the elevated values decreased, the decreased values-increased. The normal values of the immunity patterns studied were not altered during the oxidevite treatment course. Content of blood inorganic phosphorus correlated with leukocytes dynamics.
Babarykin
D A
DA
Vasipa
S B
SB
Gintere
G B
GB
Bigestan
V Ia
VIa
D000276:Adjuvants, Immunologic; D000328:Adult; D001991:Bronchitis / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000378:metabolism*; D012397:Rosette Formation
D000276:Adjuvants, Immunologic; D006887:Hydroxycholecalciferols; D010758:Phosphorus; D002118:Calcium; C008088:alfacalcidol
Immunokorrigiruiushchie svoĭstva i vliianie na fosforno-kal'tsievyĭ obmen oksidevita (1 alpha-hydroksivitamina D3).