Spontaneous and experimental hepatitis A in Old World monkeys.
Virologic, serologic, biochemical, and morphological data characterizing spontaneous hepatitis A (HA) in cynomolgus macaques (Macaca fascicularis) and green monkeys (Cercopithecus aethiops) are reported. Experimental HA was induced in macaques as a result of infection with human hepatitis A virus (HAV-h). Disease similar to human HA was induced in cynomolgus macaques by HAV isolates from spontaneously sick rhesus (M. mulatta) and green monkeys. This experimental model of HA in macaques can be used for vaccine and anti-viral preparation testing.
Shevtsova
Z V
ZV
Institute of Experimental Pathology and Therapy, USSR Academy of Medical Sciences, Sukhumi, Moscow.
Lapin
B A
BA
Doroshenko
N V
NV
Krilova
R I
RI
Korzaja
L I
LI
Lomovskaya
I B
IB
Dzhelieva
Z N
ZN
Zairov
G K
GK
Stakhanova
V M
VM
Belova
E G
EG
D000818:Animals; D002521:Cercopithecus; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D006506:Hepatitis A / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D008099:Liver / Q000473:pathology; D008251:Macaca; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D008992:Monkey Diseases / Q000453:epidemiology* / Q000473:pathology