title: Detection in human cells of alkylated macromolecules attributable to exposure to nitrosamines.
abstract: Various methods for detecting DNA alkylation adducts are described briefly, with emphasis on immunoassays using antibodies against O6-methyldeoxyguanosine (O6-medGua), O4-methylthymidine (O4-meThy) and 7-methyldeoxyguanosine (7-medGua). The application of these methods to epidemiological studies is discussed, and results obtained so far on the presence of DNA alkylation adducts in human tissues are presented.
authors.affiliation: International Agency for Research on Cancer, Lyon, France.
authors.forename: R
authors.initials: R
authors.lastname: Montesano
authors.forename: H
authors.initials: H
authors.lastname: Brésil
authors.forename: P
authors.initials: P
authors.lastname: Degan
authors.forename: G
authors.initials: G
authors.lastname: Martel-Planche
authors.forename: M
authors.initials: M
authors.lastname: Serres
authors.forename: C P
authors.initials: CP
authors.lastname: Wild
mesh_terms: D000478:Alkylation; D004247:DNA / Q000378:metabolism*; D004784:Environmental Monitoring; D006801:Humans; D007118:Immunoassay; D009369:Neoplasms / Q000139:chemically induced; D009602:Nitrosamines / Q000378:metabolism*
chemical_list: D009602:Nitrosamines; D004247:DNA