Evaluation of the efficacy of candidate vaccines against M. leprae infection in mice.
Delayed-typed hypersensitivity (DTH) response and protection value of some of the candidate vaccines alone and in combination with BCG has been investigated. It was observed that both M.w. and BCG gave heightened DTH and good protection. On the other hand both M. leprae and ICRC evoked moderate DTH and gave poor protection. However on combining any of these candidate vaccines with live BCG, the lowering of DTH and poor protection was observed except in the M. leprae combination which in spite of low DTH gave better protection.
Sreevatsa
Experimental Leprosy Laboratory, Central JALMA Institute for Leprosy, Taj Ganj, Agra.
Desikan
K V
KV
D000818:Animals; D001500:BCG Vaccine; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007918:Leprosy / Q000276:immunology / Q000517:prevention & control*; D051379:Mice; D009161:Mycobacterium / Q000276:immunology*; D015164:Vaccines, Inactivated / Q000008:administration & dosage
D001500:BCG Vaccine; D001428:Bacterial Vaccines; D015164:Vaccines, Inactivated