Bone-cell-stimulating substance.
An acid-pepsin extract of ground cancellous calf bone contains a bone-cell-stimulating substance (BCSS) that is active in the intact rat and in bone cultures. A single injection of a suspension of BCSS adjacent to the radius-ulna complex of a rat significantly increased appositional bone formation in a dose-dependent manner. The pattern of new bone deposition differed from that caused by nonspecific irritants. A suspension or water-soluble extract of BCSS significantly increased DNA and collagen synthesis in organ cultures of diaphyseal pieces of 17-day-old fetal chick tibiae. Whether or not BCSS is different from any of the other bone-derived growth factors has not been established.
Clark
I
I
Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854.
Zawadsky
J P
JP
Lin
W
W
Berg
R A
RA
D000818:Animals; D002417:Cattle; D003094:Collagen / Q000096:biosynthesis; D046508:Culture Techniques; D004247:DNA / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D006133:Growth Substances / Q000494:pharmacology*; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats
D006133:Growth Substances; D003094:Collagen; D004247:DNA