Rifampicin-isoniazid and delayed elimination of theophylline: a case report.
This paper reports a case of tuberculosis relapse and chronic obstructive lung disease treated with rifampicin and isoniazid. The subsequent introduction of slow-release theophylline therapy revealed a delay in the theophylline elimination kinetics resulting in a toxic plasma level. Interference with hepatic microsomal enzymes is considered to occur.
Dal Negro
R
R
Lung Pathophysiology Laboratory, Bussolengo Hospital, Verona, Italy.
Turco
P
P
Trevisan
F
F
De Conti
F
F
D003692:Delayed-Action Preparations; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use*; D008173:Lung Diseases, Obstructive / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012293:Rifampin / Q000627:therapeutic use*; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy*
D003692:Delayed-Action Preparations; D013806:Theophylline; D007538:Isoniazid; D012293:Rifampin