Retention of [99mTc]-d,l-HM-PAO in rat brain: an autoradiographic study.
The regional cerebral distribution pattern of [99mTc]-d,l-HM-PAO in rat brain was studied by autoradiography. The regional cerebral uptake of this tracer is related to regional cerebral blood flow (rCBF); however, the ratio of retained radioactivity (determined by digital imaging techniques) in gray matter compared to white matter is lower than that reported for the blood flow ratio. Considerable inhomogeneity is observed in cortical gray matter for at least 60 min postinjection, demonstrating that minimal, if any, cerebral redistribution of this agent occurs.
Hoffman
T J
TJ
Research and Nuclear Medicine Service, Harry S. Truman Memorial Veterans Administration Hospital, Columbia, Missouri.
Corlija
M
M
Chaplin
S B
SB
Volkert
W A
WA
Holmes
R A
RA
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D008297:Male; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D010091:Oximes / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium / Q000493:pharmacokinetics*; D019690:Technetium Tc 99m Exametazime
D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D013667:Technetium