title: Intratympanic gentamycin therapy for Menière's disease placed by tubal catheter with systemic isosorbide.
abstract: In 1974, six patients with incapacitating unilateral Menière's disease were given an empiric treatment with intratympanic gentamycin sulfate via the eustachian tube using a tubal catheter with a small side-branch. These patients then showed excellent results with relief from vertigo over a 13-year period. Since 1980, we have treated patients suffering from Menière's disease with isosorbide. When patients could not be controlled with this therapy, isosorbide was given in addition to intratympanic gentamycin therapy using a tubal catheter. Of 75 patients with Menière's disease who received gentamycin and isosorbide therapy, 41 patients could be evaluated by the classification for Menière's disease proposed by the American Academy of Ophthalmology and Otolaryngology (AAOO). Subsequent results showed that vertigo improved in 73% of the patients. According to the AAOO classification, 11 patients (27%) were group A, 16 patients (39%) were group B, and 4 patients (10%) were group C. Eleven patients were group D (27%) and experienced persistent vertigo despite treatment. Our experiences show that patients with severe Menière's disease can be readily treated with intratympanic gentamycin therapy using a tubal catheter, even on an outpatient basis. This treatment is also a most effective treatment, as it allows the effects of isosorbide to be obtained with smaller doses of gentamycin sulfate.
authors.affiliation: Department of Neurotology, Sapporo City General Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamazaki
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: N
authors.initials: N
authors.lastname: Hayashi
authors.forename: H
authors.initials: H
authors.lastname: Kozaki
mesh_terms: D000328:Adult; D000368:Aged; D002404:Catheterization / Q000295:instrumentation; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007547:Isosorbide / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy*; D008875:Middle Aged; D013012:Sorbitol / Q000031:analogs & derivatives*; D014432:Tympanic Membrane
chemical_list: D005839:Gentamicins; D013012:Sorbitol; D007547:Isosorbide