Identification and analysis of a degradation product of the glucocorticoid desonide in ointment.
The major degradation product of desonide in a pharmaceutical ointment formulation has been shown to be identical with the C-17-carboxylic acid obtained on oxidative cleavage of the alpha-ketol group of desonide with alkaline hydrogen peroxide. The pKa value of this acid has been estimated from chromatographic data.
Nguyen
T T
TT
Pharmaceutical Quality Assurance, Apothekernes Laboratorium A.S., Oslo, Norway.
Kringstad
R
R
Aasen
A J
AJ
Rasmussen
K E
KE
D002851:Chromatography, High Pressure Liquid; D003898:Desonide / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D009824:Ointments; D011246:Pregnadienetriols / Q000032:analysis*
D009824:Ointments; D011246:Pregnadienetriols; D003898:Desonide