Enhancement of antineoplastic effects of cisplatin by a calmodulin antagonist (W-7) in nude mice bearing human ovarian carcinoma.
The present study was designed to potentiate antineoplastic effects of cisplatin by combination with a calmodulin antagonist (W-7) using nude mice bearing human ovarian carcinoma. Tumor growth in nude mice treated with W-7 after (but not before) administration of cisplatin was significantly inhibited. Although treatment with cisplatin alone markedly inhibited lytic activity of the spleen cells in tumor-bearing nude mice against the tumor cells, the inhibitory effect was eliminated by subsequent treatment with W-7. There was no significant difference in the survival time between untreated and cisplatin-treated groups. Only when cisplatin was followed by W-7 was a significant enhancement by W-7 of the antitumor effect of cisplatin observed with respect to inhibition of the tumor growth as well as prolongation of the survival time.
Oomori
K
K
Department of Obstetrics and Gynecology, National Defense Medical College, Saitama, Japan.
Kikuchi
Y
Y
Kita
T
T
Iwano
I
I
Kizawa
I
I
Kato
K
K
D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D013449:Sulfonamides / Q000627:therapeutic use*
D013449:Sulfonamides; C017967:W 7; D002945:Cisplatin