Inhibition of neutrophil and monocyte functions by the monoclonal antibody TM2.
The ability of the monoclonal antibody termed TM2 to inhibit chemiluminescence generation by granulocytes and monocytes was examined. TM2 could inhibit the chemiluminescence generation of these cells when they were stimulated by all the stimuli presented. It seems that TM2 binds to the surface antigen of phagocytic cells which is important in the generation of free radicals.
Takeuchi
A
A
Second Department of Medicine, University of Teikyo, Tokyo, Japan.
Shimizu
A
A
Ohto
H
H
Hashimoto
T
T
D000818:Animals; D000911:Antibodies, Monoclonal / Q000502:physiology*; D001666:Binding Sites, Antibody; D001667:Binding, Competitive; D005947:Glucose; D005966:Glucuronidase / Q000378:metabolism; D008163:Luminescent Measurements; D008165:Luminol; D008262:Macrophage Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009000:Monocytes / Q000201:enzymology / Q000276:immunology* / Q000378:metabolism; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology* / Q000378:metabolism; D011961:Receptors, Fc / Q000276:immunology
D000911:Antibodies, Monoclonal; D011961:Receptors, Fc; D008165:Luminol; D005966:Glucuronidase; D005947:Glucose