title: The selective uptake of cholesterol by the rat tapeworm Hymenolepis diminuta (Cestoda).
abstract: 1. The sterols of Hymenolepis diminuta are almost exclusively cholesterol or similar C-27 sterols; the free sterols of its environment (the lumen of the rat intestine) are cholesterol and various phytosterols. 2. During incubation of tapeworms with mixed micelles of taurocholate, glyceryl monooleate, and equimolar [3H]cholesterol and [14C]beta-sitosterol, the uptake of cholesterol is 40 times more rapid than the uptake of sitosterol. 3. Following uptake, the desorption of labeled sitosterol is six times more rapid than that of cholesterol. 4. We did not detect the esterification of absorbed sterols or the conversion of absorbed sitosterol of cholesterol. 5. The highly selective uptake of cholesterol and the moderately selective desorption of phytosterols can account for the selective accumulation of C-27 sterol by the tapeworm.
authors.affiliation: Department of Biology, University of Iowa, Iowa City 52242.
authors.forename: W J
authors.initials: WJ
authors.lastname: Johnson
authors.forename: G D
authors.initials: GD
authors.lastname: Cain
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D002784:Cholesterol / Q000493:pharmacokinetics*; D006926:Hymenolepis / Q000378:metabolism*; D008823:Micelles; D012855:Sitosterols / Q000493:pharmacokinetics; D013261:Sterols / Q000378:metabolism / Q000493:pharmacokinetics
chemical_list: D008823:Micelles; D012855:Sitosterols; D013261:Sterols; C025473:gamma-sitosterol; D002784:Cholesterol