Erythrocyte glutathione peroxidase activity in asthmatic children.
Erythrocyte glutathione peroxidase (GPX) levels were determined in 56 asthmatic children. Lowest levels were found during acute asthmatic attack (13.53 +/- 2.94 IU) which were significantly less than controls (20.4 +/- 5.44 IU) (P less than .001). Post-attack levels 1 week later rose significantly (16.77 +/- 2.63 IU), but were still less than normal values (P = .001). GPX levels (16.96 +/- 3.28 IU) were less than controls (P less than .03) even in patients with mild symptomatology. Asymptomatic patients receiving theophylline had normal levels. Low GPX activity in asthmatic patients may play a role in the pathogenesis of the disease.
Bibi
H
H
Department of Pediatrics, Barzilai Medical Centre, Ashkelon, Israel.
Schlesinger
M
M
Tabachnik
E
E
Schwartz
Y
Y
Iscovitz
H
H
Iaina
A
A
D001249:Asthma / Q000097:blood / Q000201:enzymology*; D002648:Child; D004804:Eosinophils; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007958:Leukocyte Count; D008297:Male
D007073:Immunoglobulin E; D005979:Glutathione Peroxidase