Comparison of plasma bupivacaine concentrations during continuous extradural infusion for labour.
Twenty patients who requested extradural analgesia for labour were allocated randomly to receive an infusion of either 0.25% or 0.08% solutions of bupivacaine. Following an initial bolus dose of 50 mg, the infusions were given at a rate of 20 mg h-1. Both solutions provided acceptable pain relief, but plasma concentrations were significantly lower with the weaker concentration.
Flynn
R J
RJ
Department of Anaesthetics, Queen's University of Belfast.
McMurray
T J
TJ
Dwyer
R
R
Moore
J
J
D000328:Adult; D015360:Analgesia, Epidural; D000773:Anesthesia, Obstetrical; D002045:Bupivacaine / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007743:Labor, Obstetric; D011247:Pregnancy
D002045:Bupivacaine