Systemic availability and abortion-inducing effects of nocloprost after intravenous, subcutaneous and intragastric administration to pregnant guinea pigs.
Nocloprost was administered to 3 groups of 4 pregnant guinea pigs intravenously and subcutaneously in a dose of 30 micrograms/kg and intragastrically in a dose of 100 micrograms/kg. Plasma nocloprost levels were measured at defined times up to 24 h p. adm. with a specific radioimmunoassay and induction of abortion monitored simultaneously. In one animal per group uterus pressure was recorded continuously up to 8 hours p.adm. Animals were sacrificed 7 days p.adm. and the number and state of fetuses in utero evaluated. Systemic availability of unchanged drug was 100% after intravenous (AUCi.v. = 8.6 +/- 2.0 ng h/ml) and subcutaneous (AUCs.c. = 11.5 +/- 1.2 ng h/ml) administration and approximately 30% after intragastric administration (AUCi.g. = 8.9 +/- 2.0 ng h/ml). The incidence of abortion after intragastric administration corresponded to that after subcutaneous administration. After intravenous injection the abortion rate was somewhat less, indicating that equal AUC-values do not necessarily indicate identical pharmacological effects.
Täuber
U
U
Research Laboratories, Schering AG, Berlin, FRG.
Elger
W
W
Nieuweboer
B
B
D000028:Abortion, Induced; D000818:Animals; D001682:Biological Availability; D005260:Female; D006168:Guinea Pigs; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011461:Prostaglandins F, Synthetic / Q000493:pharmacokinetics* / Q000494:pharmacology; D013997:Time Factors
D011461:Prostaglandins F, Synthetic; C048895:nocloprost