title: Indomethacin ameliorates ischemic neuronal damage in the gerbil hippocampal CA1 sector.
abstract: The purpose of our experiment was to examine whether the cyclooxygenase inhibitor indomethacin ameliorates neuronal injury in the gerbil hippocampal CA1 sector following 5 minutes of forebrain ischemia. Thirty minutes before bilateral carotid artery occlusion, Mongolian gerbils were injected intraperitoneally with 1 (n = 10), 2 (n = 10), 5 (n = 12), or 10 (n = 7) mg/kg of indomethacin. Seven days after occlusion, the gerbils were perfusion-fixed and neuronal density in the hippocampal CA1 sector was assessed. The mean +/- SEM neuronal density in nine unoperated normal gerbils was 307 +/- 9/mm, in 10 untreated ischemic gerbils 55 +/- 21/mm, and in seven vehicle-treated ischemic gerbils 15 +/- 9/mm. The mean +/- SEM neuronal density in ischemic gerbils treated with 1, 2, 5, or 10 mg/kg indomethacin was 132 +/- 28/mm, 154 +/- 29/mm, 176 +/- 30/mm, and 136 +/- 39/mm, respectively. Indomethacin at any dose significantly ameliorated ischemic neuronal damage in the gerbil hippocampal CA1 sector.
authors.affiliation: Department of Neurosurgery, University of Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Nakagomi
authors.forename: T
authors.initials: T
authors.lastname: Kirino
authors.forename: A
authors.initials: A
authors.lastname: Tamura
authors.forename: M
authors.initials: M
authors.lastname: Noguchi
authors.forename: I
authors.initials: I
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Takakura
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D002452:Cell Count / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology*; D007213:Indomethacin / Q000494:pharmacology*; D009474:Neurons / Q000473:pathology*
chemical_list: D007213:Indomethacin