Ultrastructural characterisation of macrophages (type A cells) in the synovial lining.
The ultrastructural localisation of class II and macrophage antigens has been sought in the intimal layer of the human synovium. The cells described as type A in early morphological studies are shown to express both class II antigens and two markers of the macrophage/monocyte lineage of cells, OKM1 and MAB 24. The morphological type B cells were found to express none of these antigens. The findings are consistent with the idea that the synovial lining comprises two cell types, bone-marrow derived macrophages and mesenchymal fibroblasts.
Mapp
P I
PI
Bone and Joint Research Unit, London Hospital Medical College, Whitechapel, UK.
Revell
P A
PA
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000648:ultrastructure*; D008854:Microscopy, Electron; D013583:Synovial Membrane / Q000276:immunology / Q000648:ultrastructure*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D000949:Histocompatibility Antigens Class II