[Selectivity of the action of 1,3-dipropyl-8-phenylxanthine on the purine receptors of the intestines].
In experiments on the isolated ileum of guinea pigs and rats it was shown that 1,3-dipropyl-8-phenylxanthine (DPPX) is a highly potent adenosine antagonist blocking A1-adenosine receptors of the myenteric plexus (pA2 = 7.29 +/- 0.06) and allosterically modulating affinity of A2-receptors of the intestinal smooth muscles to adenosine (pA2 = 6.64 +/- 0.05). DPPX exerted no influence on purinergic (PR2), adrenergic and opiate receptors of the nervous and muscular cells of the intestine. Exceeding the activity of theophylline by 339-87 times, DPPX failed to exert the selective effect on A1- and A2-subtypes of adenosine receptors.
Gmiro
V E
VE
Komissarov
I V
IV
Serdiuk
S E
SE
Kharin
N A
NA
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D004347:Drug Interactions; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects*; D066298:In Vitro Techniques; D009020:Morphine / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D011983:Receptors, Purinergic / Q000187:drug effects*; D013806:Theophylline / Q000494:pharmacology; D014970:Xanthines / Q000494:pharmacology*
D011983:Receptors, Purinergic; D014970:Xanthines; D009020:Morphine; C049140:1,3-dipropyl-8-phenylxanthine; D013806:Theophylline; D000241:Adenosine; D003000:Clonidine
Izbiratel'nost' deĭstviia 1,3-dipropil-8-fenilksantina na purinovye retseptory kishechnika.