Cytogenetic analysis of sperm from a male heterozygous for a 13;14 Robertsonian translocation.
Cytogenetic analysis of 121 sperm from a man heterozygous for a t(13;14) Robertsonian translocation was performed using the technique of in vitro penetration of hamster eggs. The frequency of sperm that were chromosomally unbalanced with respect to the translocation was 27%. The frequency of chromosomally normal (36%) and balanced (38%) complements was approximately equal, as theoretically expected. There was no evidence for an interchromosomal effect since the frequency of numerical chromosomal abnormalities (2.5%) and structural chromosomal abnormalities (10.7%)--both unrelated to the translocation--were within the normal range of control donors. The ratio of X- and Y-chromosome bearing sperm was equal, and there was no evidence for preferential segregation of the X chromosome with the translocation.
Martin
R H
RH
Department of Pediatrics, Faculty of Medicine, University of Calgary, Alberta, Canada.
D000328:Adult; D002871:Chromosome Banding; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D005260:Female; D006579:Heterozygote; D006801:Humans; D007621:Karyotyping; D008297:Male; D013094:Spermatozoa / Q000648:ultrastructure*; D014178:Translocation, Genetic