A comparative study of the hepatotoxicity of 1-fluoropentane and 1-fluorohexane.
Phenobarbitone pretreatment potentiated hepatocyte lesions in male rats 24 hr after treatment with 1-fluoropentane (3.5 mg/kg body weight) and 1-fluorohexane (0.17 mg/kg body weight). Serum levels of the enzymes ornithine carbamyltransferase, glutamic-pyruvic transaminase and gamma-glutamyltranspeptidase were significantly elevated by the test compounds with the peak effect occurring 24-72 hr after a single ip administration. Significant elevation of hepatocyte triglyceride content and mitochondrial calcium and citrate levels were demonstrated 24 and 48 hr after a single ip injection of 1-fluoropentane or 1-fluorohexane, respectively.
Nhachi
C F
CF
Department of Clinical Pharmacology, Godfrey Huggins School of Medicine, University of Zimbabwe, Avondale, Harare.
Chikuni
O
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D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D004357:Drug Synergism; D006845:Hydrocarbons, Fluorinated / Q000633:toxicity*; D008099:Liver / Q000201:enzymology* / Q000648:ultrastructure; D008107:Liver Diseases / Q000201:enzymology* / Q000473:pathology; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D006845:Hydrocarbons, Fluorinated; C057999:1-fluorohexane; C057998:1-fluoropentane; D011335:Proadifen; D010634:Phenobarbital