[Evaluation of the functional state of endosteal osteoblasts in chick embryos].
The 3H-thymidine and 3H-proline autoradiography has been used to study the functional activity of endosteal osteoblasts in the femoral bone of chick embryos under normal conditions and with lead acetate intoxication (approximately 15 mcg per an egg). The obtained data show the suppression of proliferation and biosynthetic activity of osteoblasts confirmed by the reduction of 3H-thymidine and 3H-proline incorporations is osteoblasts and the rates of their transformation into osteocytes.
Nitsevich
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D000818:Animals; D001345:Autoradiography; D002642:Chick Embryo; D003094:Collagen / Q000096:biosynthesis; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D009942:Organometallic Compounds / Q000633:toxicity; D010006:Osteoblasts / Q000187:drug effects / Q000502:physiology*; D010012:Osteogenesis / Q000187:drug effects; D011392:Proline / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D009942:Organometallic Compounds; D014316:Tritium; D003094:Collagen; D004247:DNA; D011392:Proline; C008261:lead acetate; D013936:Thymidine
Otsenka funktsional'nogo sostoianiia osteoblastov éndosta u kurinykh zarodysheĭ.