Perinatal brain serotonin metabolism in rats malnourished in utero.
The fetal brain serotonin metabolism has been studied in two types of gestationally malnourished rats: protein-calorie and after ligation of one branch of the uterine artery. The results showed an elevation of L-tryptophan and serotonin content and an enhancement of tryptophan-5-hydroxylase activity in the malnourished fetal brain, continuing up to day 10 of postnatal life. The possible implications of these early changes of the serotoninergic system in brain differentiation and a lasting change in tryptophan-5-hydroxylase kinetics are proposed for further study.
Manjarréz
G
G
Hospital de Pediatría, IMSS, Centro Médico Nacional, México, DF.
Chagoya
G
G
Hernández
J
J
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D005260:Female; D005865:Gestational Age; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010922:Placenta Diseases / Q000378:metabolism*; D010927:Placental Insufficiency / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism; D014365:Tryptophan Hydroxylase / Q000378:metabolism
D009419:Nerve Tissue Proteins; D012701:Serotonin; D014364:Tryptophan; D014365:Tryptophan Hydroxylase