Physical properties of a new synthetic oxygen carrier.
PFC emulsions have shown considerable promise for a variety of clinical indications, but their utility has been limited by instability outside the frozen state, extended tissue residence time, and complement activation. A new formulation from Adamantech, INc. based on F-MA and egg yolk phospholipid shows significant improvement in each of these areas. The emulsion can be stored in the non-frozen state, has a tissue half-life of 8-9 days, has excellent rheological properties, and does not activate complement.
Moore
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Adamantech, Inc., Linwood, PA.
D000218:Adamantane / Q000031:analogs & derivatives / Q000633:toxicity; D000818:Animals; D001802:Blood Substitutes; D004530:Egg Yolk; D004655:Emulsions; D005466:Fluorocarbons / Q000633:toxicity; D010100:Oxygen / Q000097:blood*; D010743:Phospholipids; D051381:Rats; D012995:Solubility; D014783:Viscosity
D001802:Blood Substitutes; D004655:Emulsions; D005466:Fluorocarbons; D010743:Phospholipids; C057525:perfluoromethyladamantane; D000218:Adamantane; D010100:Oxygen