Effects of HIV superinfection on HBV replication in a chronic HBsAg carrier with liver disease.
A case of HIV superinfection observed in an HBsAg/HBeAg-positive male homosexual with chronic persistent hepatitis is described. Soon after the appearance of clinical and serological features of acute HIV infection, a rapid fall to a normal value of ALT was noted with simultaneous recrudescence of HBV replication lasting for several months as detected by an increase of the HBV-DNA concentration in the serum. Our observations suggest that the reduction of hepatocyte necrosis and the increase in HBV replication were a consequence of impaired T cell function during acute HIV infection.
Pastore
G
G
Department of Internal Medicine and Infectious Diseases, University of Bari, Italy.
Santantonio
T
T
Monno
L
L
Milella
M
M
Luchena
N
N
Angarano
G
G
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000911:Antibodies, Monoclonal; D002180:Candidiasis, Oral / Q000150:complications; D002353:Carrier State; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000502:physiology*; D006521:Hepatitis, Chronic / Q000150:complications*; D006801:Humans; D008297:Male; D015163:Superinfection; D014779:Virus Replication
D000911:Antibodies, Monoclonal; D006514:Hepatitis B Surface Antigens