Novel antifungal antibiotics octacosamicins A and B. II. The structure elucidation using various NMR spectroscopic methods.
The structures of octacosamicins A and B, two new antifungal antibiotics, were studied by spectrometries and chemical modifications. The 2D NMR techniques including 1H-detected heteronuclear multiple bond correlation method were successfully applied to this study. These antibiotics have unique linear chain structure possessing N-hydroxyguanidyl group at the terminal.
Dobashi
K
K
Institute of Microbial Chemistry, Tokyo, Japan.
Naganawa
H
H
Takahashi
Y
Y
Takita
T
T
Takeuchi
T
T
D000935:Antifungal Agents; D055598:Chemical Phenomena; D002621:Chemistry; D006146:Guanidines / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy
D000935:Antifungal Agents; D006146:Guanidines; C058021:octacosamicin B; C058020:octacosamicin A