[Effect of oxybutynin on lower urinary tract function].
The effect of oxybutynin on lower urinary tract function was studied by combined recording of cystometry and sphincter electromyogram (EMG) in 7 decerebrate dogs. Micturition was induced by bladder filling before and after oxybutynin. The statistical analysis was carried out on the urodynamic parameters. Oxybutynin at a dose of 30, 100, and 300 micrograms/kg significantly increased the threshold volume during the collecting phase in a dose dependent manner. In the urodynamic parameters of the emptying phase considered to be influenced by cholinergic activity there was a small but significant decrease in maximum pressure only at 300 micrograms/kg. Therefore, oxybutynin is probably acting as a strong antispasmodic agent. Oxybutynin seems to be useful for the relief of symptoms associated with detrusor instability and hyperreflexia.
Nishizawa
O
O
Department of Urology, Akita University School of Medicine.
Sugaya
K
K
Suzuki
T
T
Kohama
T
T
Matsuzaki
A
A
Fukuda
T
T
Harada
T
T
Tsuchida
S
S
D000818:Animals; D003655:Decerebrate State; D004285:Dogs; D008333:Mandelic Acids / Q000494:pharmacology*; D010276:Parasympatholytics / Q000494:pharmacology*; D014521:Urethra / Q000187:drug effects* / Q000502:physiology; D001743:Urinary Bladder / Q000187:drug effects* / Q000502:physiology; D014554:Urination / Q000187:drug effects*; D014563:Urodynamics / Q000187:drug effects
D008333:Mandelic Acids; D010276:Parasympatholytics; C005419:oxybutynin