title: Peliosis hepatis induced by 6-thioguanine administration.
abstract: A patient with acute myeloblastic leukaemia developed jaundice revealing peliosis hepatis after receiving 6-thioguanine for two months. Peliosis hepatis was severe and was associated with mild lesions of centrilobular veins. Withdrawal of 6-thioguanine was followed by a progressive improvement of liver dysfunction. This report shows that 6-thioguanine, a thiopurine already reported to be responsible for veno-occlusive disease of the liver, can induce peliosis hepatis. This suggests that some liver vascular disorders caused by thiopurines (6-thioguanine, azathioprine and 6-mercaptopurine), particularly peliosis hepatis, veno-occlusive disease, sinusoidal dilatation and perisinusoidal fibrosis, might be related syndromes caused by similar lesions at different sites.
authors.affiliation: Unit157e de Recherches de Physiopathologie Hépatique (INSERM U 24), Hôpital Beaujon, Clichy, France.
authors.forename: D
authors.initials: D
authors.lastname: Larrey
authors.forename: E
authors.initials: E
authors.lastname: Fréneaux
authors.forename: A
authors.initials: A
authors.lastname: Berson
authors.forename: G
authors.initials: G
authors.lastname: Babany
authors.forename: C
authors.initials: C
authors.lastname: Degott
authors.forename: D
authors.initials: D
authors.lastname: Valla
authors.forename: D
authors.initials: D
authors.lastname: Pessayre
authors.forename: J P
authors.initials: JP
authors.lastname: Benhamou
mesh_terms: D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008875:Middle Aged; D010382:Peliosis Hepatis / Q000139:chemically induced*; D013866:Thioguanine / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D013866:Thioguanine