title: Multiple unrelated clonal chromosome abnormalities in an in situ squamous cell carcinoma of the skin.
abstract: We have cytogenetically analyzed short-term cultures from an in situ squamous cell carcinoma of the skin (Bowen's disease). The following mosaic tumor karyotype was found: 46,XX, -1, +der(1)(pter----p22::q11----cen----p22:), -9, +der(9)t(1;9)(q11; p24)/46,XX,t(3;6) (q21;p21)/46,XX,t(5;14)(q13;q24),t(7;18)(q32;q11)/46,XX,t(8;11)(p22;q13) /46, XX,t(8;11) (p22;q13),t(15;17) (q13;q24)/46,XX,t(12;15)(q12;p11). None of the rearrangements correspond to previously known cancer-associated abnormalities. Two of the clones are obviously related, and it is reasonable to assume that the t(15;17) developed as an evolutionary change in a cell that already contained t(8;11)(p22;q13). Since five clones without cytogenetic similarities were found in this in situ skin carcinoma, we suggest that the tumor was of polyclonal origin. It is impossible to decide whether all, or indeed any, of the visible abnormalities constitute pathogenetically essential primary changes, or merely represent chromosomal markers of secondary importance in tumorigenesis.
authors.affiliation: Department of Clinical Genetics, Lund University Hospital, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: Y
authors.initials: Y
authors.lastname: Jin
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: A
authors.initials: A
authors.lastname: Biörklund
authors.forename: J
authors.initials: J
authors.lastname: Wennerberg
authors.forename: N
authors.initials: N
authors.lastname: Jonsson
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D002278:Carcinoma in Situ / Q000235:genetics* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D006801:Humans; D007621:Karyotyping; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology