title: Fatal Stevens-Johnson syndrome following urography with iopamidol in systemic lupus erythematosus.
abstract: A 46 year old white woman with active systemic lupus erythematosus developed a skin rash 8 hours after intravenous urography with the non-ionic contrast medium iopamidol. Severe Stevens-Johnson syndrome with erythema multiforme, intrahepatic cholestasis, pulmonary infiltrates and acute renal failure ensued, leading to her death. Although non-ionic contrast media are generally less toxic than traditional ionic agents, their use in patients with immunological disease may be hazardous.
authors.affiliation: Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Savill
authors.forename: R
authors.initials: R
authors.lastname: Barrie
authors.forename: S
authors.initials: S
authors.lastname: Ghosh
authors.forename: M
authors.initials: M
authors.lastname: Muhlemann
authors.forename: P
authors.initials: P
authors.lastname: Dawson
authors.forename: C D
authors.initials: CD
authors.lastname: Pusey
mesh_terms: D005260:Female; D006801:Humans; D007479:Iopamidol / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008875:Middle Aged; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced*; D014567:Urography / Q000009:adverse effects
chemical_list: D007479:Iopamidol