Suppression of UV mutagenicity by human interferon.
Effects of human interferon (HuIFN)-alpha on UV mutagenicity were examined in a human cell strain, RSa, and xeroderma pigmentosum (XP)-derived fibroblasts (XP1KY). The frequency of ouabain-resistance mutation in UV-irradiated RSa cells was unusually high (Suzuki et al., 1985), but that in cells pretreated with HuIFN-alpha before irradiation was reduced. 6-Thioguanine-resistance mutation was also depressed in XP1KY cells treated with HuIFN-alpha before irradiation. However, the depression of UV mutagenicity by HuIFN-alpha was lessened by treatment with cycloheximide immediately after UV irradiation. The relationship between HuIFN-depressed UV mutagenicity and HuIFN-affected DNA-repair and repair-related functions is discussed.
Suzuki
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Department of Microbiology, School of Medicine, Chiba University, Japan.
Suzuki
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H
D002460:Cell Line; D003513:Cycloheximide / Q000494:pharmacology; D004260:DNA Repair / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000494:pharmacology*; D009154:Mutation / Q000187:drug effects* / Q000528:radiation effects*; D011837:Radiation-Protective Agents; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum
D007370:Interferon Type I; D011837:Radiation-Protective Agents; D003513:Cycloheximide