title: Multiple sclerosis with early childhood onset. A case report.
abstract: A 2 year old boy was admitted owing to a subacute episode of ataxic gait and hearing deficit. Computerized tomography (CT) was normal and cerebrospinal fluid (CSF) analysis revealed gamma globulins level of 15.4% (normal 7 to 14%). There was spontaneous remission after 7 months. At 5 years of age the boy incurred a second episode with predominantly right appendicular ataxia and tonic gaze deviation to the right side. CT showed a low-density lesion in the white matter adjacent to the right frontal horn. Visual and auditory evoked potentials were abnormal. CSF revealed a mild increase in gamma globulins level of 14.5% with an abnormal T lymphocyte subsets study. The combination of visual, cerebellar, brain stem and paraventricular lesions with clear remissions and exacerbations, supported by CT, CSF and evoked potentials findings suggests the diagnosis of multiple sclerosis even at this early age.
authors.affiliation: Department of Neurology, University of São Paulo School of Medicine, Brasil.
authors.forename: M I
authors.initials: MI
authors.lastname: Vergani
authors.forename: R
authors.initials: R
authors.lastname: Reimão
authors.forename: A M
authors.initials: AM
authors.lastname: Silva
authors.forename: M
authors.initials: M
authors.lastname: Muskat
authors.forename: S
authors.initials: S
authors.lastname: Espósito
authors.forename: A
authors.initials: A
authors.lastname: Diament
mesh_terms: D000367:Age Factors; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005072:Evoked Potentials, Auditory; D005073:Evoked Potentials, Somatosensory; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis*; D009900:Optic Nerve / Q000503:physiopathology; D014057:Tomography, X-Ray Computed