[Cellular modification during acquisition of drug-resistance to anticancer agents].
In this article, we describe plausible mechanisms for drug-resistance of tumor cells to anticancer agents and also cellular modification associated with drug-resistance including heterogenous population of tumor cells, altered response to growth factor, and tumorigenicity of drug-resistant.
Kohno
K
K
Dept. of Biochemistry, Oita Medical School.
Kikuchi
J
J
Kuwano
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D004351:Drug Resistance; D066246:ErbB Receptors / Q000032:analysis; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology*
D000970:Antineoplastic Agents; D066246:ErbB Receptors