title: Effects of high pressure and vanadium on cell growth.
abstract: We have investigated the effects on cultured cells of high pressure separately and combined with vanadate. Growth of Chinese hamster ovary cells was reduced at pressure above 75 bar; the reduction was 31.6% at 185 bar. Vanadate inhibited cell growth at 5 microM and abolished growth at 100 microM. Combined exposure to vanadate and high pressure changed the toxicity of vanadate: at 5 microM, the toxicity decreased for pressure up to 100 bar; above 100 bar, 5 microM vanadate was more toxic to the cells than at normobaric pressure.
authors.affiliation: University of Trondheim, Faculty of Medicine, Department of Pharmacology and Toxicology, Trondheim, Norway.
authors.forename: J
authors.initials: J
authors.lastname: Jenssen
authors.forename: T
authors.initials: T
authors.lastname: Syversen
mesh_terms: D000818:Animals; D001274:Atmospheric Pressure; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D006874:Hydrostatic Pressure; D014639:Vanadium / Q000633:toxicity*
chemical_list: D014639:Vanadium