Serum ribonucleotide binding activity in osteoarthritis.
Previous investigations assessing ribonucleotide binding in the sera of patients with diverse forms of connective tissue disease unexpectedly identified positive responses in control osteoarthritic subjects. The current study, using a radiolabelled assay, confirms the presence of a polyadenylic acid (Poly [A] binding factor(s) in the sera of a group of 50 well-characterized patients having primary or secondary forms of this disease process as contrasted with matched control subjects. The significance of such binding activity is unknown. No significantly meaningful correlation could be established between serum Poly (A) binding levels and clinical or x-ray parameters of disease.
Tangnijkul
Y
Y
Department of Internal Medicine, University of Cincinnati Medical Center, Ohio 45267.
Adams
L E
LE
Herman
J H
JH
D000042:Absorption; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood*; D011061:Poly A / Q000097:blood*; D011897:Random Allocation
D011061:Poly A