[ADP-ribosylation of nuclear proteins in the rat brain].
The distribution of (ADP-ribose)n synthesized from [14C]NAD labeled at the adenyl ring in several protein fractions of isolated rat brain nuclei was studied. Preferential ADP-ribosylation of nonhistone nuclear proteins was shown to occur. It was demonstrated that pol (ADP-ribose)polymerase and DNA-topoisomerase II are located spatially close to each other. A correlation between ADP-ribosylation and the activity of nuclear matrix DNA-topoisomerase II was established.
Zaalishvili
T M
TM
Kolkhidashvili
K M
KM
Margiani
D O
DO
Michilashvili
R D
RD
D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D002467:Cell Nucleus / Q000201:enzymology / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004278:DNA, Superhelical / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D009243:NAD / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D051381:Rats
D004278:DNA, Superhelical; D009687:Nuclear Proteins; D009243:NAD; D000246:Adenosine Diphosphate Ribose; D004247:DNA
ADP-ribozilirovanie iadernykh belkov golovnogo mozga krys.