[The action of heart factor H1 on the synthesis and uptake of dopamine and noradrenaline in the rat heart].
The action of heart factor H1 on the synthesis and uptake of dopamine and noradrenaline in the atria and ventricle of rat heart and also the participation of Ca2+ and ATP in the action of H1 was studied. It has been shown, that H1 in the doses of 2 and 20 mU/ml increases the synthesis of 14C-dopamine in the atria by 43-44% and does not effect on this process in ventricle. The synthesis of 14C-noradrenaline in the atria increases in the presence of H1 (2-20 mU/ml) by 64 and 40%. A dose-dependent decrease of 3H-dopamine uptake in the atria under the influence of H1 was observed. The uptake of 3H-noradrenaline in the ventricle as well as in the atria is not altered in the presence of H1. In the absence of Ca2+ H1 in not caused any stimulation of 14C-dopamine and 14C-noradrenaline synthesis in the atria. But in the absence of both Ca2+ and ATP the stimulating effect of H1 on the synthesis of 14C-noradrenaline is maintained.
Chiflikian
M D
MD
Grigorian
G G
GG
Marukian
T Kh
TKh
Oganesian
A O
AO
Grigorian
L A
LA
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002250:Carbon Radioisotopes; D004298:Dopamine / Q000096:biosynthesis*; D006020:Glycopeptides / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects / Q000378:metabolism; D006352:Heart Ventricles / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000096:biosynthesis*; D051381:Rats; D014443:Tyrosine / Q000378:metabolism
D002250:Carbon Radioisotopes; D006020:Glycopeptides; D014443:Tyrosine; D000255:Adenosine Triphosphate; D002118:Calcium; D004298:Dopamine; D009638:Norepinephrine
Deĭstvie serdechnogo faktora H1 na sintez i zakhvat dofamina i noradrenalina v serdtse krys.