The metabolism of 1-methylhydantoin via 5-hydroxy-1-methylhydantoin in mammals.
The metabolic pathway of 1-methylhydantoin (2) via 5-hydroxy-1-methylhydantoin (3), methylparabanic acid (4) and N5-methyloxaluric acid (5) proved to be a major and general one in mammals. Hence the formation of (3), which has not been detected in normal tissue, is likely to be indirect in inflamed tissue, probably depending on the arising formation of (2) from creatinine (1).
Ienaga
K
K
Institute of Bio-Active Science, Nippon Zoki Pharmaceutical Co., Ltd., Hyogo, Japan.
Nakamura
K
K
Naka
F
F
Goto
T
T
D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D006827:Hydantoins / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D051381:Rats
D006827:Hydantoins; C032067:1-methylhydantoin; C058007:5-hydroxy-1-methylhydantoin