Intraocular pressure increase associated with epsilon-aminocaproic acid therapy for traumatic hyphema.
We treated five patients receiving epsilon-aminocaproic acid who demonstrated sudden and accelerated clot dissolution with accompanying increases in intraocular pressure 24 to 96 hours after discontinuing treatment. All of these patients required additional ocular hypotensive medications and one patient required anterior chamber washout for persistently increased intraocular pressure. These findings suggest that certain patients with hyphema may be at risk for significant intraocular pressure increases following cessation of epsilon-aminocaproic acid therapy.
Dieste
M C
MC
Eye Emergency Service, Massachusetts Eye and Ear Infirmary, Boston 02114.
Hersh
P S
PS
Kylstra
J A
JA
Larrison
W I
WI
Frambach
D A
DA
Shingleton
B J
BJ
D000293:Adolescent; D000328:Adult; D000614:Aminocaproates / Q000627:therapeutic use*; D015119:Aminocaproic Acid / Q000627:therapeutic use*; D000867:Anterior Chamber / Q000473:pathology / Q000503:physiopathology; D001777:Blood Coagulation; D004912:Erythrocytes / Q000473:pathology; D005131:Eye Injuries / Q000150:complications; D005260:Female; D006801:Humans; D006988:Hyphema / Q000188:drug therapy* / Q000209:etiology; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged
D000614:Aminocaproates; D015119:Aminocaproic Acid