Metabolic effects of glucagon on plasma and urine zinc, copper, calcium and magnesium levels.
The present study determines the effect of glucagon on the behavior of zinc, copper, calcium and magnesium ions in human plasma and urine. Five normal adults were submitted to intravenous infusion of 2.0 mg glucagon over a period of 120 min. A decrease in plasma magnesium and copper was observed with no significant change in urine ion concentrations. We related plasma magnesium mobilization to glucagon, and copper mobilization to plasma variation in free fatty acids and albumin.
Brandão-Neto
J
J
Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Brasil.
Kimachi
T
T
Veríssimo
J M
JM
Shuhama
T
T
Marchini
J S
JS
Antunes-Rodrigues
J
J
D000328:Adult; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D003300:Copper / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005260:Female; D005934:Glucagon / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007262:Infusions, Intravenous; D008274:Magnesium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D015032:Zinc / Q000097:blood / Q000378:metabolism* / Q000652:urine
D003300:Copper; D005934:Glucagon; D008274:Magnesium; D015032:Zinc; D002118:Calcium