title: Acute effect of intravenous magnesium sulfate on airway obstruction of asthmatic patients.
abstract: The bronchodilating effect of magnesium sulfate (MgSO4) was studied in ten asthmatic patients with moderate to severe airway obstruction. Two grams of MgSO4 or saline in double-blind crossover design was administered IV for 20 minutes (0.40 mmol/min) and forced expiratory capacity and forced expiratory volume in one second (FEV1) were studied at intervals. Only at the end of MgSO4 infusion did FEV1 increase significantly (109% of initial values). The bronchodilating effect was short lasting and far less than that observed after salbutamol.
authors.affiliation: Medical Clinic, University of Turin, Molinette Hospital, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Rolla
authors.forename: C
authors.initials: C
authors.lastname: Bucca
authors.forename: E
authors.initials: E
authors.lastname: Caria
authors.forename: W
authors.initials: W
authors.lastname: Arossa
authors.forename: M
authors.initials: M
authors.lastname: Bugiani
authors.forename: L
authors.initials: L
authors.lastname: Cesano
authors.forename: A
authors.initials: A
authors.lastname: Caropreso
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000188:drug therapy; D001249:Asthma / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008274:Magnesium / Q000097:blood; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged
chemical_list: D008278:Magnesium Sulfate; D008274:Magnesium