title: Hydrogenation reduces the allergenicity of colophony (rosin).
abstract: Abietic acid is the main component of rosin. It is readily oxidized by air and its oxidation products are considered to be mainly responsible for the allergenic effect. Hydrogenation of the conjugated double bonds of abietic acid decreases its susceptibility to air oxidation and would thus reduce the allergenicity of rosin. Portuguese gum rosin was therefore hydrogenated and its allergenicity was compared with that of unmodified rosin in animal experiments and by patch testing in humans. Its sensitizing potential was determined in 2 studies. No response was found according to the FCAT method while the GPMT gave significant response in the animals challenged with the highest test concentration. Hydrogenated rosin showed no eliciting activity in animals induced with unmodified rosin according to the GPMT method. A marked decrease was found in the frequency of allergic reactions to hydrogenated rosin compared to the reactions to unmodified rosin in patients with known allergy to gum rosin. We conclude that elimination of the unsaturated non-aromatic compounds by hydrogenation considerably reduces the allergenicity of Portuguese gum rosin.
authors.affiliation: Department of Occupational Dermatology, National Institute of Occupational Health, Solna, Sweden.
authors.forename: A T
authors.initials: AT
authors.lastname: Karlberg
authors.forename: A
authors.initials: A
authors.lastname: Boman
authors.forename: J L
authors.initials: JL
authors.lastname: Nilsson
mesh_terms: D045784:Abietanes; D000485:Allergens; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003877:Dermatitis, Contact / Q000276:immunology; D004224:Diterpenes / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D006859:Hydrogen; D010328:Patch Tests / Q000379:methods; D010616:Phenanthrenes; D012116:Resins, Plant / Q000276:immunology*
chemical_list: D045784:Abietanes; D000485:Allergens; D004224:Diterpenes; D010616:Phenanthrenes; D012116:Resins, Plant; C013913:dehydroabietic acid; D006859:Hydrogen; C013893:rosin; C023710:abietic acid