Thyroid function in patients with pustulosis palmoplantaris.
Fifty consecutive patients (45 women and 5 men) with pustulosis palmoplantaris were evaluated for thyroid disease. Five women had previously had thyroid disorders for which they were receiving thyroxine substitution therapy. Of the other 40 women three had a raised serum concentration of thyroid-stimulating hormone and nine had high concentrations of antibodies against thyroid "microsomal antigen." During a 4-year follow-up hypothyroidism developed in two women with initially raised thyroid-stimulating hormone, and laboratory test results for one woman indicated subclinical hyperthyroidism. Four of nine patients with thyroid abnormality also had evidence of gastric autoimmunity. Of the patients 94% smoked at the onset of pustulosis palmoplantaris compared with 33% in age- and sex-matched healthy controls. The prevalence of thyroid disease in women with pustulosis palmoplantaris was significantly higher than in a comparable population sample of women from the same geographic region. We conclude that patients with pustulosis palmoplantaris should be screened for thyroid disease.
Rosén
K
K
Department of Dermatology, University of Göteborg, Sweden.
Lindstedt
G
G
Mobacken
H
H
Nyström
E
E
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D005533:Foot Dermatoses / Q000150:complications*; D006229:Hand Dermatoses / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology; D013959:Thyroid Diseases / Q000150:complications*; D013961:Thyroid Gland / Q000276:immunology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use
D001323:Autoantibodies; D013972:Thyrotropin; D013974:Thyroxine