Inactivation pattern of the fragile X in heterozygous carriers.
In this report we present new data on BrdU-inactivation studies in lymphocytes of five heterozygotes. The present data confirm our previous findings that the prediction of the mental status of female heterozygote carriers cannot be based on the X-inactivation pattern. The general tendency to carry the fragile site on the active X is confirmed and the results of previous studies and hypotheses are reviewed.
Fryns
J P
JP
Centre for Human Genetics, University of Leuven, Belgium.
Van den Berghe
H
H
D000328:Adult; D004303:Dosage Compensation, Genetic; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics* / Q000523:psychology; D006579:Heterozygote; D006801:Humans; D007360:Intelligence; D008214:Lymphocytes / Q000648:ultrastructure; D010641:Phenotype; D012729:Sex Chromosome Aberrations / Q000235:genetics*