[Value and limitations of the study of gamma-enolase in cerebrospinal fluid as evidence of neuronal degeneration].
Elevation of the gamma-chain of the glycolytic enzyme enolase in the cerebrospinal fluid has previously been reported as a parameter for neuronal damage. The authors evaluated this by measuring gamma-enolase in the CSF of a number of patients with neurological disease known to produce neuronal damage, using a commercial radioimmuno-assay test kit. All measurements were done when gamma-enolase levels had been reported to be maximal during the course of the disease. The results suggest that, as a parameter for neuronal damage, gamma-enolase is not as reliable as reported. An elevation of gamma-enolase in the CSF seems to reflect serious disease; this could be important in differentiating encephalitis caused by Herpes Simplex virus from other viral encephalitides. A normal level of gamma-enolase does not exclude severe neuronal damage.
van den Doel
E M
EM
Service de Neurologie, Baarn, Pays-Bas.
Rijksen
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Staal
G E
GE
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004660:Encephalitis / Q000134:cerebrospinal fluid / Q000201:enzymology; D004827:Epilepsy / Q000134:cerebrospinal fluid / Q000201:enzymology; D006561:Herpes Simplex / Q000134:cerebrospinal fluid / Q000201:enzymology; D006801:Humans; D007223:Infant; D008875:Middle Aged; D009410:Nerve Degeneration; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid / Q000201:enzymology; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid*
D010751:Phosphopyruvate Hydratase
Intérêt et limites de l'étude de la gamma-énolase dans le liquide céphalo-rachidien comme témoin de la dégradation neuronale.