Stimulation of plasma fibronectin production in mice by muroctasin.
The production of plasma fibronectin (PFN) in mice treated subcutaneously with N2-[(N-acetylmuramoyl)-L-alanyl-D-isoglutaminyl]-N6-stearoyl-L-lysine (MDP-Lys(L18), muroctasin), was examined. The plasma levels of PFN in mice increased significantly by treatment with a single dose of 10 to 100 micrograms/mouse of MDP-Lys(L18). A slight strain difference in the PFN levels among Std: ddY, C3H/He, and DBA 2 mice was observed: the percent increases at the maximal level in Std: ddY, C3H/He, and DBA/2 mice were 21.6, 19.9, and 10.4, respectively. In Std: ddY mice, the concentration of PFN reached the maximal level at 15 h post-treatment, and decreased gradually of the normal level by 48 h. These results indicate that MDP-Lys(L18) stimulates the PFN production in mice.
Endo
N
N
Department of Microbiology and Immunology, School of Health Sciences, Kyorin University, Tokyo, Japan.
Okuda
T
T
Osada
Y
Y
Zen-Yoji
H
H
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D005353:Fibronectins / Q000096:biosynthesis* / Q000097:blood; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA
D000276:Adjuvants, Immunologic; D005353:Fibronectins; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C036866:romurtide