title: [Elevated kynurenine concentration in the blood serum of children with epilepsy and bronchial asthma].
abstract: A total of 84 children were investigated: 15 with bronchial asthma, 41 with combined seizure and bronchial obstruction syndrome, 14 with epilepsy. The kynurenine blood level was found to correlate with seizures. It was highest in epilepsy (5.27 +/- 0.99 nM/ml) together with the lowest dioxygenase activity (0.53 +/- 0.29 nM/ml) as measured with the tryptophane loading. The data suggest that kynurenine being a major tryptophane metabolite plays a role in pathogenesis of convulsive states.
authors.forename: N A
authors.initials: NA
authors.lastname: Ivanova
authors.forename: I V
authors.initials: IV
authors.lastname: Ryzhov
authors.forename: V V
authors.initials: VV
authors.lastname: Buzdin
authors.forename: Z S
authors.initials: ZS
authors.lastname: Nikitina
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004827:Epilepsy / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D007737:Kynurenine / Q000097:blood*; D008297:Male; D011014:Pneumonia / Q000097:blood; D013053:Spectrophotometry; D014364:Tryptophan
chemical_list: D007737:Kynurenine; D014364:Tryptophan
vernacular_title: Povyshenie kontsentratsii kinurenina v syvorotke krovi u deteĭ, bol'nykh épilepsieĭ i bronkhial'noĭ astmoĭ.