Immunomodulating effect of neurotropin on delayed type hypersensitivity response in mice.
Effect of Neurotropin on the delayed type hypersensitivity (DTH) response to sheep red blood cells was examined in mice. Neurotropin suppressed the high DTH responses in ddY and BALB/c mice, while it enhanced the low DTH response in C57BL/6 mice when administered after sensitization. In addition, Neurotropin exerted a suppressive effect on the enhanced DTH response by cyclophosphamide pretreatment in C57BL/6 mice, but had a restorative effect on the suppressed DTH response in ddY mice loaded with restraint stress.
Yoshii
H
H
Department of Immunology and Allergy, Nippon Zoki Pharmaceutical Company, Hyogo, Japan.
Matsuoka
T
T
Kurimoto
Y
Y
Suehiro
S
S
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011134:Polysaccharides / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D011134:Polysaccharides; C010491:neurotropin