title: Timing of autopsy-confirmed hemorrhagic infarction with reference to cardioembolic stroke.
abstract: We studied the temporal profile of hemorrhagic transformation in 34 cases with autopsy-confirmed hemorrhagic infarction who died within 15 days following a supratentorial brain infarct, provided they had undergone computed tomography. It appeared that within 4 days, at least 76% (95% confidence interval 39-100%) of 21 cardioembolic strokes had become hemorrhagic. We conclude that if anticoagulation is considered in cardioembolic stroke, such treatment should not be started sooner than at least 4 days after the onset of stroke, provided that computed tomography at that time shows no hemorrhagic infarction.
authors.affiliation: Department of Neurology, University Hospital, Maastricht, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Lodder
authors.forename: B
authors.initials: B
authors.lastname: Krijne-Kubat
authors.forename: P J
authors.initials: PJ
authors.lastname: van der Lugt
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D001344:Autopsy; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology; D002544:Cerebral Infarction / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology; D003327:Coronary Disease / Q000150:complications*; D004617:Embolism / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000925:Anticoagulants