title: Cytogenetics of unfertilized human oocytes.
abstract: During an in-vitro fertilization programme 150 oocytes from 62 women with a mean age of 31 years (range 24-39) remained unfertilized. Successful chromosome analysis was carried out on 96 oocytes by Q-banding: 59 (61.5%) oocytes bore a normal haploid complement, 8 (8.3%) were diploid and 3 (3.1%) tetraploid. In 26 (27.1%) oocytes aneuploidy was observed; these included 9 (9.4%) nullisomic, 5 (5.2%) double nullisomic, 4 (4.2%) triple nullisomic and 2 (2.1%) disomic oocytes. The remaining 54 (36.0%) oocytes could not be evaluated. A nearly uniform rate of aneuploidy was found for unfertilized oocytes among different donor age groups.
authors.affiliation: Department of Clinical Genetics, University of Ulm, Federal Republic of Germany.
authors.forename: M
authors.initials: M
authors.lastname: Djalali
authors.forename: B
authors.initials: B
authors.lastname: Rosenbusch
authors.forename: M
authors.initials: M
authors.lastname: Wolf
authors.forename: K
authors.initials: K
authors.lastname: Sterzik
mesh_terms: D000328:Adult; D000782:Aneuploidy; D002874:Chromosome Mapping; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000235:genetics*; D009865:Oocytes / Q000166:cytology*; D011003:Ploidies