Myocardial free fatty acid metabolism of the ischemic heart treated by left ventricular assist device.
Three-beta-methyl-iodophenyl-pentadecanoic acid (BMIPP), a newly developed radiographic probe of metabolic processes in tissue free fatty acid (FFA), was applied to a study analyzing the effect of a left ventricular assist device (LVAD) on impaired dog hearts. The radiographic image obtained with BMIPP was compared with 201thallium chloride (TL) imaging, which indicates tissue perfusion. In the myocardial infarction (MI) model, the BMIPP and TL uptake were equally increased with the use of LVAD in the marginal area of the MI. In another model using the reperfused myocardium after ischemia, the BMIPP and TL uptake were increased in the reperfused area by LVAD pumping. On the other hand, BMIPP uptake in the residual myocardium of both models was decreased by LVAD pumping when compared with TL uptake. This discrepancy between these radiographic tracers in the residual myocardium suggests that tissue metabolic processes may be suppressed as result of a decrease in the energy demand by the myocardium caused by LVAD pumping. The results of this study showed that use of LVADs for the impaired heart improved cell function of "stunned" myocardium and also unloaded the excess work from the residual myocardium as judged by FFA metabolism.
Noda
H
H
Department of Artificial Organs, National Cardiovascular Center, Osaka, Japan.
Nishimura
T
T
Kinoshita
M
M
Taenaka
Y
Y
Kihara
K
K
Sago
M
M
Hayashi
M
M
Takano
H
H
Akutsu
T
T
D000818:Animals; D001243:Assisted Circulation; D004285:Dogs; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D006321:Heart / Q000000981:diagnostic imaging; D006353:Heart-Assist Devices; D007462:Iodobenzenes; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D011877:Radionuclide Imaging; D013793:Thallium
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D007462:Iodobenzenes; C049338:iodofiltic acid; C027549:thallium chloride; D013793:Thallium