Influence of food on the absorption of flurithromycin in man.
Oral absorption of flurithromycin, a new fluorinated macrolide, has been evaluated on eight healthy volunteers on fasting and after a standard meal. Serum levels from 0 to 8 hours, peak serum concentrations, times to peak and areas under the curves were compared using a balanced sequence cross-over design. The highest mean concentration was reached after 3 h from administration on fasting (1.36 +/- 0.31 mcg/ml) and after 1 h following a meal (1.36 +/- 0.30 mcg/ml). All the pharmacokinetic parameters considered showed no statistical change. Therefore a meal does not reduce or delay the absorption of flurithromycin, while in the presence of food other macrolides may behave differently. Moreover the tolerability to the drug was good, lacking any report of side-effects, either on fasting or after the food.
Lepore
A M
AM
Pierrel S.p.A., Research & Development, Milan, Italy.
Bonardi
G
G
Maggi
G C
GC
D000328:Adult; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D005215:Fasting; D005502:Food; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D013997:Time Factors
C045925:flurithromycin; D004917:Erythromycin