The influence of nimodipine on cerebral blood flow autoregulation and blood-brain barrier.
Twenty anesthetized rats were randomly assigned to a nimodipine-treated group or a control group of 10 rats each. Local cerebral blood flow (lCBF) was measured by means of a surface electrode using the hydrogen clearance technique. Systemic arterial pressure (SAP) was varied with administration of norfenefrine or by hemorrhage in order to obtain SAP/cerebral blood flow (CBF) curves under different conditions. In the control group, a typical autoregulation curve was obtained with an lCBF plateau between 70 and 120 mm Hg SAP. The nimodipine-treated animals, however, showed only a slight diminution in the slope of the curve but no real plateau, indicating impairment of CBF autoregulation. In another series, 20 anesthetized rats were randomly assigned to a treatment group or a control group of 10 animals each. Intravenous Evans blue dye was used as a tracer for blood-brain barrier (BBB) function. In both groups, SAP was raised to a level of 180 mm Hg with administration of norfenefrine for 6 minutes. Extravasation of significantly more Evans blue dye was observed in the nimodipine group than in the control group, indicating impairment of the BBB. It is concluded that nimodipine may impair CBF autoregulation, allowing damage to the BBB under hypertensive conditions.
Höllerhage
H G
HG
Department of Neurosurgery, Hannover Medical School, West Germany.
Gaab
M R
MR
Zumkeller
M
M
Walter
G F
GF
D000818:Animals; D001794:Blood Pressure; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004566:Electrodes; D005070:Evans Blue; D006706:Homeostasis / Q000187:drug effects*; D006973:Hypertension / Q000503:physiopathology; D008856:Microscopy, Fluorescence; D009553:Nimodipine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012212:Rheology / Q000295:instrumentation
D005070:Evans Blue; D009553:Nimodipine