Vinpocetine prevents ischemic cell damage in rat hippocampus.
The effects of vinpocetine on hippocampal cell damage and local cerebral blood flow (LCBF) were measured in a rat model of forebrain ischemia (2-vessel occlusion and hypotension). Duration of ischemia was 10 min. LCBF was determined after 2 min of recirculation using the 14C-iodoantipyrine technique. Hippocampal cell loss was quantified histologically 7 days post-ischemia. Intraperitoneal application of vinpocetine (10 mg/kg) 15 min prior to ischemia significantly reduced neuronal cell loss in hippocampal CA 1 sector from 60% to 28%. The drug led to a marked increase in blood flow in cortical areas, whereas LCBF remained unchanged in hippocampus and all other structures measured. It is suggested that the protective effect of vinpocetine does not depend on increased postischemic blood flow.
Sauer
D
D
Institut für Pharmakologie und Toxikologie, Philipps-Universität, Marburg, F.R.G.
Rischke
R
R
Beck
T
T
Rossberg
C
C
Mennel
H D
HD
Bielenberg
G W
GW
Krieglstein
J
J
D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004195:Disease Models, Animal; D006624:Hippocampus / Q000098:blood supply* / Q000187:drug effects; D002546:Ischemic Attack, Transient / Q000517:prevention & control*; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D014665:Vasodilator Agents / Q000627:therapeutic use*; D014748:Vinca Alkaloids / Q000494:pharmacology / Q000627:therapeutic use*
D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C013983:vinpocetine