Inhibitory effect of TJ-960 (SK) on pentylenetetrazol-induced EEG power spectrum changes.
Effects of the Japanese kampo medicine 'Shosaiko-to-go-keishika-shyakuyaku-to' (TJ-960), which is a mixture of 9 herbal drugs and is practically equivalent to 'Saiko-keishi-to' (SK), on the pentylenetetrazol (PTZ)-induced EEG power spectrum changes were examined. The EEG power spectrum change with 2 PTZ administrations at an 80 min interval was clearly inhibited by oral administration of 1.0 mg/kg of TJ-960. By separate single administrations of the main component herbal drugs, Bupleuri radix, Cinnamomi cortex, Paeoniae radix and Zingiberis rhizoma, only Paeoniae radix showed statistically significant inhibition of PTZ-induced EEG power spectrum changes at a proportional dose of 1.0 mg/kg of TJ-960. The other main component herbal drugs showed no statistically significant inhibitory effect although they had a tendency to inhibit. These findings suggest that the Japanese Kampo medicine, TJ-960 (SK), has an inhibitory effect on PTZ-induced power spectrum changes and one of the component herbal drugs, Paeoniae radix, is the important component drug.
Sugaya
E
E
Department of Physiology, Kanagawa Dental College, Yokosuka, Japan.
Ishige
A
A
Sekiguchi
K
K
Iizuka
S
S
Ito
K
K
Sugimoto
A
A
Aburada
M
M
Hosoya
E
E
D000284:Administration, Oral; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004569:Electroencephalography; D008297:Male; D010433:Pentylenetetrazole; D008517:Phytotherapy; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; C018142:saiko-keishi-to; D010433:Pentylenetetrazole