The influence of biosynthetic human growth hormone on biomechanical properties and collagen formation in granulation tissue.
Biomechanical properties and collagen formation in the granulation tissue of cellulose sponges, implanted subcutaneously in male rats for 7, 10 and 16 days, were tested after treatment with biosynthetic human growth hormone given subcutaneously in a dose of 0.5 mg/kg body weight/day. At each implantation period, one group started hormone treatment at the day of implantation and another group started hormone treatment 7 days prior to implantation. After 7 days of implantation, increases in maximum stress (36 per cent), relative failure energy (48 per cent) and strain at maximum stress (25 per cent) were found when treatment was started 7 days prior to implantation. After 10 days of implantation an increase in relative failure energy (60 per cent) was found when treatment was started 7 days prior to implantation. No differences were found after 7 and 10 days of implantation when treatment was started at the day of implantation. After 16 days of implantation, no influence on mechanical strength was found in any of the hormone treated groups. The collagen deposition after 7, 10 and 16 days did not differ in any of the hormone treated groups compared to controls.
Jørgensen
P H
PH
Department of Connective Tissue Biology, University of Aarhus, Denmark.
Andreassen
T T
TT
D000818:Animals; D001696:Biomechanical Phenomena; D003094:Collagen / Q000096:biosynthesis*; D006097:Granulation Tissue / Q000187:drug effects* / Q000378:metabolism; D013006:Growth Hormone / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D013006:Growth Hormone; D003094:Collagen