Subacute toxicity of muroctasin in mice and dogs.
The subacute toxicity of N2-[(N-acetylmuramoyl)-L-alanyl-D-isoglutaminyl]-N6-stearoyl-L-lysine (MDP-Lys (L18), muroctasin), a synthetic muramyl dipeptide, was investigated in mice and dogs. Both species exhibited leukocytosis, immunologically activated appearances of the axillary lymphnode and splenic white pulp, and irritatic lesions at the injection site, when treated with MDP-Lys(L18) for 4 weeks. Anemia, and synovitis were also found in dogs. These findings reflected main pharmacological action of MDP-Lys(L18), though there was some species difference.
Ono
Y
Y
Research Institute, Daiichi Seiyaku Co., Ltd., Tokyo, Japan.
Iwasaki
T
T
Sekiguchi
M
M
Onodera
T
T
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000633:toxicity; D000276:Adjuvants, Immunologic / Q000633:toxicity*; D000740:Anemia / Q000139:chemically induced; D000818:Animals; D004285:Dogs; D005260:Female; D006965:Hyperplasia; D007964:Leukocytosis / Q000139:chemically induced; D008198:Lymph Nodes / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013585:Synovitis / Q000139:chemically induced
D000276:Adjuvants, Immunologic; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C036866:romurtide