Gene for parathyroid hormone-like peptide is on rat chromosome 2.
Parathyroid hormone-like peptide (PLP) is thought to be a mediator of hypercalcemia in both human and rodent malignancies. A rat PLP cDNA was used as a hybridization probe in Southern blot analysis of DNAs isolated from a panel of rat-mouse somatic cell hybrids. The single-copy gene for PLP was assigned to rat chromosome 2, whereas the rat parathyroid hormone (PTH) gene has previously been assigned to rat chromosome 1. Consequently, despite significant amino-terminal homology between PLP and PTH the genes encoding these peptides in the rat as well as human species have discrete chromosomal localizations.
Hendy
G N
GN
Department of Medicine, McGill University, Montreal, PQ, Canada.
Sakaguchi
A Y
AY
Yasuda
T
T
Weber
D K
DK
Wang
L M
LM
Yoshida
M C
MC
Banville
D
D
Goltzman
D
D
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D009363:Neoplasm Proteins / Q000235:genetics*; D044162:Parathyroid Hormone-Related Protein; D051381:Rats / Q000235:genetics*; D013045:Species Specificity
D009363:Neoplasm Proteins; D044162:Parathyroid Hormone-Related Protein