Serum and urinary aluminum levels in patients receiving alum-precipitated allergenic extracts.
Indications of aluminum (Al) loading and possible toxicity were sought on three occasions in each of six otherwise healthy patients on maintenance therapy with alum-precipitated allergenic extracts. As compared with age-matched controls receiving conventional aqueous immunotherapy, alum-treated patients had slightly higher levels of serum and urinary Al, suggesting slightly increased body burdens. Neither serum Al levels nor calculated urinary aluminum:creatinine ratios fell outside the broad normal ranges currently accepted for these determinations. Furthermore, no patient showed laboratory or clinical evidence of aluminum toxicity.
Glinert
R J
RJ
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor.
Burnatowska-Hledin
M
M
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000008:administration & dosage; D000535:Aluminum / Q000097:blood* / Q000652:urine; D000536:Aluminum Hydroxide / Q000008:administration & dosage* / Q000633:toxicity; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008297:Male
D000276:Adjuvants, Immunologic; D000485:Allergens; D000536:Aluminum Hydroxide; D000535:Aluminum