title: [Morphological pathology of classic Kaposi's sarcoma. Ultrastructural studies and reflections on histogenesis].
abstract: Histological and electron-microscopic studies were conducted into biopsy material from cases of what is called the classical type of idiopathic Kaposi's sarcoma without acquired immunodeficiency syndrome. Ultrastructural analysis was conducted, with the view to characterizing a possible progenitor cell from which the angioblastic and fibroblastic elements were likely to originate. The biopsy material had been obtained from two males, aged 86 or 83 years, who had been afflicted with the disease for 18 or 8 years. The nodular lesions were typical of Kaposi's sarcoma and were, histologically, made up of variable mixtures of vascular and spindle cell elements. The angiomatous structures were a capillary meshwork or sinusoidal patterns lined by atypical endothelial cells. The spindle cell areas contained large numbers of slit-like spaces which were without endothelial lining but were stuffed with erythrocytes. Flattened endothelioid cells were recordable from semi-thin-sections of some clefts. Haemosiderin was, typically, deposited in places. Electron microscopically, the endothelial cells of vascular channels exhibited varying amounts of characteristic organelles, such as Weibel-Palade bodies, microfilaments and pinocytotic vesicles as well as basal membranes. Cells with typical endothelial markers, too, were detectable in solid sprouts or in capillary-like differentiations with narrow or small lumina. The spindle cell tumour areas consisted of fibroblastic cells with plenty of rough endoplasmic reticulum and surrounded by material of basal membrane nature. Also visible were solid, sprout-type multilayer cell complexes surrounded by basal membranes which exhibited undifferentiated or primitive cellular forms, endothelioid and pericytic. Transitional forms from these complexes to the above vascular tumours or the spindle-cell formations were detectable. These ultrastructural findings might be interpreted to the effect that an angioblastically determined mesenchymal cell, a so-called endothelioblast, was thinkable and was discussed as the precursor cell of atypical vascular and spindle cell proliferation in Kaposi's sarcoma.
authors.affiliation: Institut für Pathologische Anatome, Martin-Luther-Universität Halle - Wittenberg, DDR.
authors.forename: H J
authors.initials: HJ
authors.lastname: Holzhausen
authors.forename: D
authors.initials: D
authors.lastname: Stiller
authors.forename: M
authors.initials: M
authors.lastname: Sachs
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001485:Basement Membrane / Q000648:ultrastructure; D001706:Biopsy; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D004727:Endothelium / Q000473:pathology / Q000648:ultrastructure; D006485:Hemosiderin / Q000032:analysis; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D012514:Sarcoma, Kaposi / Q000473:pathology / Q000648:ultrastructure*
chemical_list: D006485:Hemosiderin
vernacular_title: Morphologische Pathologie des klassischen Kaposi-Sarkoms. Ultrastrukturelle Untersuchungen und Betrachtungen zur Histogenese.