title: Sensitivity of normal and neoplastic human renal tubular epithelium to hyperthermia.
abstract: Comparison of the intrinsic thermosensitivity of malignant and normal homologous cells are important in evaluating the therapeutic role of hyperthermia in cancer. However, such comparisons had problems with establishing the origin of cells grown in culture. Using monoclonal antibodies we have shown that human kidney cancer lines, Caki-1 and Caki-2, and a normal human renal epithelium line, NHK-4, originated from proximal convoluted tubular epithelium. The observed order of thermosensitivity was Caki-2 greater than Caki-1 greater than NHK-4.
authors.affiliation: Department of Pathology, Dalhousie University, Halifax, N.S., Canada.
authors.forename: S
authors.initials: S
authors.lastname: Dessureault
authors.forename: P
authors.initials: P
authors.lastname: Brown
authors.forename: T
authors.initials: T
authors.lastname: Ghose
authors.forename: O P
authors.initials: OP
authors.lastname: Kamra
authors.forename: P
authors.initials: P
authors.lastname: Belitsky
mesh_terms: D000911:Antibodies, Monoclonal; D002460:Cell Line; D004848:Epithelium / Q000473:pathology; D006358:Hot Temperature; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D007687:Kidney Tubules, Proximal / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal