Alteration by perfluorodecalin of hepatic metabolism and excretion of phenobarbital.
The bile duct was cannulated in rats that had been infused intravenously with an emulsion of perfluorodecalin at intervals from 2 to 34 weeks earlier. After injection of [14C]phenobarbital, urine and bile were collected during the next 24 hr and were analyzed for phenobarbital and its metabolites. There was a decrease in the biliary excretion of phenobarbital and its metabolites for several weeks after infusion of perfluorodecalin, but conjugation of the metabolites was not decreased. The reduced excretion returned to normal after about 20 weeks.
Huang
R
R
Harrison Department of Surgical Research, School of Medicine, University of Pennsylvania, Philadelphia 19104.
Levin
S S
SS
Schleyer
H
H
Cooper
D Y
DY
Mukherji
B
B
Sloviter
H A
HA
D000818:Animals; D001646:Bile / Q000378:metabolism; D005466:Fluorocarbons / Q000494:pharmacology*; D006900:Hydroxylation; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010634:Phenobarbital / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D005466:Fluorocarbons; C008805:perfluorodecalin; D010634:Phenobarbital