Synovial lymphocyte responses to microbial antigens differentiate the arthritis of enteric reactive arthritis from the arthritis of inflammatory bowel disease.
Synovial lymphocyte responses to microbial antigens were measured by the 3H-thymidine uptake method in 5 patients with bacteriologically defined enteric reactive arthritis and 7 patients with arthritis associated with inflammatory bowel disease. All the patients with enteric reactive arthritis had maximal synovial lymphocyte responses to the relevant enteric antigen; in contrast, the synovial lymphocytes of the patients with inflammatory bowel disease all responded maximally to nonenteric antigens.
Ford
D K
DK
Department of Medicine, University of British Columbia, Vancouver, Canada.
Schulzer
M
M
D000942:Antigens, Bacterial / Q000276:immunology*; D001170:Arthritis, Infectious / Q000209:etiology*; D001424:Bacterial Infections / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis; D007410:Intestinal Diseases / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D007422:Intestines / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D013582:Synovial Fluid / Q000166:cytology*
D000942:Antigens, Bacterial