title: Comparative activity of cefotetan against plasmid-encoded aminoglycoside-resistant enterobacteria strains.
abstract: 304 strains of R-plasmid harbouring enterobacteria resistant to aminoglycosides were studied for their susceptibilities to a range of antibiotics, including cefotetan. Cefotetan and latamoxef were the most active of the four cephamycins tested and all were stable to the beta-lactamases produced by these strains. No new beta-lactamases (SHV-2, CTX-1, TEM-4, CAZ-1) were found in these strains capable of hydrolysing third generation cephalosporins. The activity of cefotetan against these multi-resistant, beta-lactamase producing strains may be of clinical value.
authors.affiliation: Department of Microbiology, University Hospital, Zaragoza, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Gomez-Lus
authors.forename: I
authors.initials: I
authors.lastname: Otal
authors.forename: M L
authors.initials: ML
authors.lastname: Gomez-Lus
authors.forename: C
authors.initials: C
authors.lastname: Sarraseca
authors.forename: J
authors.initials: J
authors.lastname: Castillo
authors.forename: J
authors.initials: J
authors.lastname: Gil
authors.forename: M C
authors.initials: MC
authors.lastname: Rubio
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015313:Cefotetan / Q000494:pharmacology*; D002513:Cephamycins / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009070:Moxalactam / Q000494:pharmacology; D011815:R Factors
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002513:Cephamycins; D015313:Cefotetan; D009070:Moxalactam