title: Pharmacokinetics of ciprofloxacin in carp, African catfish and rainbow trout.
abstract: The plasma disposition of ciprofloxacin was studied in carp, African catfish and trout after intravenous (IV) and intramuscular (IM) administration at a dose rate of 15 mg/kg. Pharmacokinetic analysis of IV data showed that ciprofloxacin was well distributed (distribution volume Vd(area): 3.08-5.59 litre/kg) and exhibited a similar elimination half-life of about 14 h in these 3 fish species. After IM administration to carp and trout a rapid absorption was noticed; the maximum ciprofloxacin plasma concentrations (mean: 3.49 and 2.37 micrograms/ml, respectively), were achieved within 1 h after injection. At the dose level applied, ciprofloxacin has potential therapeutic value for 2-5 days especially against gram-negative bacterial fish pathogens.
authors.affiliation: Department of Experimental Animal Morphology & Cell Biology, Agricultural University, Wageningen, The Netherlands.
authors.forename: J F
authors.initials: JF
authors.lastname: Nouws
authors.forename: J L
authors.initials: JL
authors.lastname: Grondel
authors.forename: A R
authors.initials: AR
authors.lastname: Schutte
authors.forename: J
authors.initials: J
authors.lastname: Laurensen
mesh_terms: D000818:Animals; D002347:Carps / Q000097:blood / Q000378:metabolism; D002397:Catfishes / Q000097:blood / Q000378:metabolism; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005399:Fishes / Q000097:blood / Q000378:metabolism*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D014337:Trout / Q000097:blood / Q000378:metabolism
chemical_list: D002939:Ciprofloxacin