title: Zinc deficiency: specific scalp hair defects seen by scanning electron microscopy may provide a valuable new test.
abstract: Zinc deficiency in man results in multisystem disease. It may be acquired or hereditary; the latter can be fatal if left untreated. Premature babies are particularly susceptible to zinc deficiency. Unfortunately no simple, reliable test for zinc status exists at present. Short, newly-emerging scalp hair samples from 3 classical cases of zinc deficiency all showed the same characteristic abnormalities when examined by scanning electron microscopy, i.e. straight, blunt tips bearing scales, unusually thick cuticular scales with jagged free-edges, and very fine longitudinal corrugations in individual scales. These abnormal features occurring together appear to be specific for zinc deficiency; they also varied in severity with marked variations in zinc status during follow-up studies. Due to the relative rarity of classic cases of zinc deficiency, it is not possible for one centre of our catchment size to conduct a preplanned study. However, if the present findings can be confirmed elsewhere, it is concluded that scanning electron microscopy of appropriately-selected hairs may provide a valuable new test for the diagnosis of zinc deficiency and for monitoring the response to zinc therapy.
authors.affiliation: Department of Bacteriology, University of Aberdeen, Scotland.
authors.forename: D W
authors.initials: DW
authors.lastname: Gregory
authors.forename: L
authors.initials: L
authors.lastname: Stankler
mesh_terms: D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006197:Hair / Q000648:ultrastructure*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis*; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D015032:Zinc / Q000172:deficiency*
chemical_list: D015032:Zinc