The importance of sodium concentration on the incidence of fibrillation during coronary arteriography in dogs.
Coronary arteriography is known to produce electrical disturbances including conduction disturbances, arrhythmias, and ventricular fibrillation. A canine model for studying ventricular fibrillation has been developed that uses relatively long injections in the right coronary artery. In experiments in 49 dogs over a five-year period, the authors have consistently observed that with low osmolality contrast media, the incidence of ventricular fibrillation becomes quite high when the formulation contains less than 3.2 mmol/L sodium. This effect seems independent of the concentration of the contrast media molecules. High concentrations of the ionic monomer diatrizoate cause fibrillation despite high sodium concentrations.
Morris
T W
TW
Department of Diagnostic Radiology and Physiology, University of Rochester Medical Center, NY 14642.
D000792:Angiography; D000818:Animals; D003287:Contrast Media / Q000633:toxicity*; D017023:Coronary Angiography; D004285:Dogs; D005260:Female; D007269:Injections, Intra-Arterial; D008297:Male; D009994:Osmolar Concentration; D012964:Sodium / Q000494:pharmacology*; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000139:chemically induced*
D003287:Contrast Media; D012964:Sodium