Immune response to H-2 class I antigens on platelets. I. Immunogenicity of platelet class I antigens.
Purified allogeneic murine platelet suspensions were found unable to induce primary anti-H-2 class I antibody or T cell proliferative responses. In contrast, the same platelet suspensions could elicit secondary anti-class I responses. The secondary responses were not due to contaminating leucocytes. Possible explanations, the lack of acolyte determinants (class II or non- H-2) on platelets or inappropriate layout and/or structure of their class I antigens, are discussed. These findings emphasize the importance of sufficient leucocyte depletion before platelet transfusion in the human.
Frangoulis
B
B
U 93 INSERM, Saint Louis Hospital, Paris, France.
Besluau
D
D
Chopin
M
M
Degos
L
L
Pla
M
M
D000818:Animals; D001792:Blood Platelets / Q000276:immunology*; D002455:Cell Division; D006183:H-2 Antigens / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains
D006183:H-2 Antigens; D015395:Histocompatibility Antigens Class I