Pharmacological studies on anethole trithione.
Pharmacological studies on trithio-p-methoxy-phenylpropene (anethole trithione, ANTT, Felviten) were performed. ANTT at a dose of 100 mg/kg, p.o. lowered the increased serum transaminases GOT and GPT, and protected the liver from injuries caused by CCl4 in mice. In other studies in vivo, ANTT at a dose of 1000 mg/kg showed no effect on the central nervous system or the autonomic nervous system. In vitro experiments with smooth muscle preparations showed no significant effects of ANTT.
Ukai
Y
Y
Research Laboratories, Nippon Shinyaku Co., Ltd., Kyoto, Japan.
Shiraishi
M
M
Takeshita
K
K
Fukui
T
T
Kura
K
K
Kimura
K
K
D000781:Anethole Trithione / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000840:Anisoles / Q000494:pharmacology*; D001341:Autonomic Nervous System / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology / Q000627:therapeutic use; D004573:Electrolytes / Q000652:urine; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D011680:Pupil / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000517:prevention & control; D012890:Sleep / Q000187:drug effects; D014590:Uterine Contraction / Q000187:drug effects
D000840:Anisoles; D004573:Electrolytes; D003975:Diazepam; D000781:Anethole Trithione