title: [Genetic restriction of delayed-type hypersensitivity to tuberculin in mice].
abstract: An adoptive local transfer method has been used to study the immunological features and genetic restriction of cell interaction during the development of the delayed-type hypersensitivity (DTH) to tuberculin in mice. Peritoneal cells from the BCG-infected mice transfer the DTH to intact animals (into hind footpad) in both syngeneic and allogeneic donor-recipient combinations. Nonadherent cells (macrophage-deleted) transfer the reaction in syngeneic but not allogeneic combination. The use of H-2 recombinant mouse strains demonstrated that successful transfer of the DTH requires I-A subregion compatibility. Treatment of CBA cells with anti-Thy-1.2 antiserum abrogates the reaction transfer. These results indicate that antigen presentation to immune T-cells proliferating during DTH to tuberculin is mediated through the molecular products of the I-A subregion.
authors.forename: B V
authors.initials: BV
authors.lastname: Nikonenko
authors.forename: M B
authors.initials: MB
authors.lastname: Mezhlumova
authors.forename: A M
authors.initials: AM
authors.lastname: Moroz
authors.forename: A S
authors.initials: AS
authors.lastname: Apt
mesh_terms: D000818:Animals; D006183:H-2 Antigens / Q000235:genetics* / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000235:genetics* / Q000276:immunology; D007116:Immunization, Passive; D051379:Mice; D008815:Mice, Inbred Strains; D015183:Restriction Mapping
chemical_list: D006183:H-2 Antigens
vernacular_title: Geneticheskaia restriktsiia giperchuvstvitel'nosti zamedlennogo tipa k tuberkulinu u mysheĭ.