Atherosclerosis of cynomolgus monkeys hyper- and hyporesponsive to dietary cholesterol. Lack of effect of vasectomy.
A moderately atherogenic diet was fed to young adult cynomolgus macaque males that were observed to be either hypo- or hyperresponsive to dietary cholesterol and who were randomized into groups to be either vasectomized or sham-vasectomized. The extent of atherosclerosis was found to be considerably greater at all arterial sites studied for the monkeys that were hyperresponsive to dietary cholesterol. The differences in atherosclerosis development among the hyperresponder monkeys occurred primarily in the proximal portions of the coronary arteries, the proximal and distal portions of the common carotid arteries, and only in the most proximal portions of the femoral arteries. There were no significant effects of vasectomy or sham vasectomy on atherosclerosis extent in either the hyper- or the hyporesponding groups, although there was a suggestion of somewhat larger lesions in the left circumflex coronary artery of hyperresponder monkeys that were vasectomized and somewhat smaller atherosclerotic lesions in the left common carotid arteries of vasectomized monkeys. The data presented here do not support our first report of worsened atherosclerosis among cynomolgus monkeys fed diets high in cholesterol. The findings of the current study are consistent with recent epidemiological studies of vasectomized and nonvasectomized human males.
Clarkson
T B
TB
Arteriosclerosis Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 21703.
Alexander
N J
NJ
Morgan
T M
TM
D000818:Animals; D000906:Antibodies / Q000032:analysis; D001012:Aorta, Abdominal / Q000473:pathology; D001013:Aorta, Thoracic / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology* / Q000473:pathology; D002339:Carotid Arteries / Q000473:pathology; D002448:Cell Adhesion; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D008076:Cholesterol, HDL / Q000097:blood; D003331:Coronary Vessels / Q000473:pathology; D004036:Diet, Atherogenic; D004730:Endothelium, Vascular / Q000473:pathology; D005263:Femoral Artery / Q000473:pathology; D008055:Lipids / Q000097:blood; D008252:Macaca fascicularis; D008297:Male; D009000:Monocytes / Q000473:pathology; D013094:Spermatozoa / Q000276:immunology; D014659:Vasectomy / Q000009:adverse effects*
D000906:Antibodies; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008055:Lipids; D002784:Cholesterol