[Innervation, activity rhythm and accumulation of myosin light chains in a fast muscle of chickens].
The fast posterior latissimus dorsi muscle (PLD) of the chick ceases to accumulate slow myosin light chains (MLC) during neonatal development. On day 18 of embryonic life slow MLC represented only 2% of total MLC, and LC3F was first detected. In chick embryo, spinal cord stimulation at a slow rhythm modifies PLD differentiation toward the slow type: LC3F did not accumulate and slow MLC increased. In contrast, stimulation at a fast rhythm accelerated LC3F accumulation. PLD denervation on day 2 after hatching inhibited the synthesis of LC3F. Direct stimulation at a fast rhythm led to post-hatching development into normal fast type while a slow rhythm influenced the development of denervated PLD towards the slow type. In innervated PLD, the effect of stimulation at a slow rhythm was less important than in denervated PLD. These results suggest that the rhythm of the neural and/or contractile activity plays an important role in the MLC expression during embryonic and post-natal development of the chicken fast muscle.
Gardahaut
M F
MF
Groupe de Physiologie Cellulaire, Centre de Recherche de Biologie et Physico-Chimie Cellulaires, Faculté des Sciences, Nantes, France.
Khaskiye
A
A
Rouaud
T
T
Renaud
D
D
Le Douarin
G
G
D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D004558:Electric Stimulation; D009121:Muscle Denervation; D024510:Muscle Development; D009132:Muscles / Q000196:embryology / Q000294:innervation; D009218:Myosins / Q000378:metabolism*; D013116:Spinal Cord / Q000502:physiology
D009218:Myosins
Innervation, rythme d'activité et accumulation des chaînes légères de myosine d'un muscle rapide de poulet.