1-Methyl-3-phenyl-1,2,4-triazinium-5-olate: a new zwitterion with cytotoxic activity against human cancer cell-lines.
One of 6 newly synthesized triazinium zwitterions (JR-1--JR-6) was shown to induce 51Cr-release from leukemic (HL60 and CEM) and solid tumor (MM170 and HeLa) cell-lines. Leukemic cells were more sensitive to this compound than solid tumors as demonstrated by dose-response and time-course studies. Other experiments showed that JR-6 (1-methyl-3-phenyl-1,2,4-triazinium-5-olate) significantly suppressed protein, RNA and DNA synthesis at tumoricidal concentrations.
Vuddhakul
V
V
Department of Child Health, Mater Children's Hospital, South Brisbane, Australia.
Jacobsen
N W
NW
Rose
S E
SE
Ioannoni
B
B
Seow
W K
WK
Thong
Y H
YH
D000970:Antineoplastic Agents; D002455:Cell Division; D002460:Cell Line / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007938:Leukemia; D008545:Melanoma; D014227:Triazines / Q000138:chemical synthesis / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D014227:Triazines; C057604:1-methyl-3-phenyl-1,2,4-triazin-5-one