The effect of leukotriene D4 on pulmonary and systemic circulation in conscious newborn piglets.
In a conscious newborn piglet model, exogenous leukotriene D4 was found to be a potent pulmonary and systemic vasoconstrictor with significant left ventricular depressant effect. The pulmonary pressor effect was seen only in the arterioles and not the veins. In hypoxia the pulmonary response was less. The findings were similar to that in lambs. The role of leukotrienes in hypoxic pulmonary vasoconstriction and the foetal pulmonary circulation needs further elucidation.
Coe
J Y
JY
Cardiovascular Research Focus and Neurosciences Division, Hospital for Sick Children, Toronto, Canada.
Olley
P M
PM
Coceani
F
F
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D011652:Pulmonary Circulation / Q000187:drug effects*; D013189:SRS-A / Q000494:pharmacology*; D013552:Swine; D013997:Time Factors; D014661:Vasoconstriction / Q000187:drug effects*
D013189:SRS-A