title: No detectable increase in sister chromatid exchanges in lymphocytes from mycosis fungoides patients after topical treatment with nitrogen mustard.
abstract: We measured sister chromatid exchanges (SCEs) in lymphocytes of eight MF patients before, and 2 h, and 24 h after treatment with topical nitrogen mustard. The mean number of SCEs/cell (+/- SEM) were 8.15 (+/- 0.62), 8.34 (+0.55) and 8.26 (+/- 0.56), respectively. The 2 h and 24 h results do not differ significantly from pretreatment levels. Our results show that concentrations of nitrogen mustard used to control MF do not induce SCEs in peripheral blood lymphocytes.
authors.affiliation: Department of Dermatology, University Hospital, Copenhagen, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Studstrup
authors.forename: H I
authors.initials: HI
authors.lastname: Beck
authors.forename: P
authors.initials: P
authors.lastname: Bjerring
authors.forename: H C
authors.initials: HC
authors.lastname: Wulf
authors.forename: K
authors.initials: K
authors.lastname: Lundgren
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D008466:Mechlorethamine / Q000627:therapeutic use*; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy* / Q000235:genetics; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000235:genetics
chemical_list: D008466:Mechlorethamine