title: Case report: dapsone hypersensitivity syndrome associated with treatment of the bite of a brown recluse spider.
abstract: Dapsone (4-4-diaminodiphenyl-sulfone) is a member of the sulfone group of antibiotics used in the treatment of leprosy and various dermatitidies and more recently employed in the management of local reactions to the bite of the brown recluse spider, Loxosceles reclusa. A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy. A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented.
authors.affiliation: Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232.
authors.forename: R C
authors.initials: RC
authors.lastname: Wille
authors.forename: J D
authors.initials: JD
authors.lastname: Morrow
mesh_terms: D000743:Anemia, Hemolytic / Q000209:etiology; D003622:Dapsone / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005334:Fever / Q000209:etiology; D006261:Headache / Q000209:etiology; D006505:Hepatitis / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000209:etiology; D001098:Spider Bites / Q000188:drug therapy*; D013577:Syndrome; D014839:Vomiting / Q000209:etiology
chemical_list: D003622:Dapsone