The effect of low dose rate on recovery of hemopoietic and stromal progenitor cells in gamma-irradiated mouse bone marrow.
Long-term recovery of mouse hemopoietic stem cells (CFU-S and CFU-S per colony), granulocyte-macrophage precursor cells (GM-CFC), and stromal colony-forming units (CFU-F) after doses up to 12.5 Gy was almost complete by 1 year when the dose rate was reduced to 0.0005 Gy/min compared to incomplete recovery after doses up to only 6.5 Gy given at greater than 0.7 Gy/min. This sparing effect of dose rate on long-term hemopoietic recovery is in contrast to the generally reported lack of dependence on dose rate for acute survival of hemopoietic progenitors after doses up to 5 Gy. The present results are compatible with the hypothesis that good recovery of the stroma should be reflected in the long-term recovery of hemopoiesis.
Gallini
R
R
Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.
Hendry
J H
JH
Molineux
G
G
Testa
N G
NG
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D002470:Cell Survival; D002588:Cesium Radioisotopes; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D006098:Granulocytes / Q000166:cytology / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000528:radiation effects*; D008264:Macrophages / Q000166:cytology / Q000528:radiation effects; D008297:Male; D051379:Mice
D002588:Cesium Radioisotopes; D003037:Cobalt Radioisotopes