Physico-chemical properties of muroctasin.
N2-[(N-acetylmuramoyl)-L-alanyl-D-isoglutaminyl-N6-stearoyl-L-lysine (MDP-Lys(L18), muroctasin) was studied to clarify its chemical structure and physico-chemical properties. The chemical structure of MDP-Lys(L18) was confirmed by UV, IR, NMR and MS analyses as well as by elemental analysis. The physico-chemical properties were investigated by thermal analysis, powder X-ray analysis, ionization constant measurement, high-performance liquid and thin-layer chromatography.
Moroi
R
R
Research Institute, Daiichi Seiyaku Co., Ltd., Tokyo, Japan.
Yamazaki
K
K
Hirota
T
T
Watanabe
S
S
Kataoka
K
K
Ichinose
M
M
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000032:analysis; D000276:Adjuvants, Immunologic / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004055:Differential Thermal Analysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009904:Optical Rotation; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D000276:Adjuvants, Immunologic; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C036866:romurtide