title: Fragile X syndrome and acute lymphoblastic leukemia.
abstract: Fragile X [Fra(X)] syndrome is an example of a heritable fragility syndrome associated with mental retardation. It is characterized by a fragile site on the X chromosome at Xq27-28. There have recently been three reports of malignant solid tumors associated with Fra(X) syndrome. We describe the first case of a hematologic malignancy [T-cell acute lymphocytic leukemia (ALL)] in a patient with Fra(X) syndrome. The possibility of a predisposition to malignancy in Fra(X) is discussed.
authors.affiliation: Department of Pediatrics, University of Vermont, College of Medicine, Burlington, VT 05405.
authors.forename: M
authors.initials: M
authors.lastname: Cunningham
authors.forename: J D
authors.initials: JD
authors.lastname: Dickerman
mesh_terms: D002675:Child, Preschool; D005600:Fragile X Syndrome / Q000150:complications*; D006801:Humans; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D012729:Sex Chromosome Aberrations / Q000150:complications*