Effect of dichlorvos on the activity of lipoprotein lipase from adipose tissue, on plasma lipids and postheparin lipolytic plasma activity in rats.
The activity of lipoprotein lipase (LPL) from adipose tissue, the postheparin lipolytic activity (PHLA) in plasma, and the content of plasma lipoproteins were investigated in rats poisoned with dichlorvos (DDVP). Administration of a single dose (50% LD50) resulted in inhibition of LPL and PHLA; the greatest inhibition was observed at 24 and 48 h after administration of the posticide. The metabolism of serum lipoproteins was also altered; the content of triacylglycerols in very low density lipoproteins (VLDL) and low density lipoproteins (LDL) fractions was increased; the content of cholesterol was increased in VLDL and high density lipoproteins (HDL) fractions, and decreased in the LDL fraction. On repeated administration of small DDVP doses (5% LD50) the greatest changes were observed after 90 days of intoxication. The levels of all three determined lipoprotein fractions, as well as PHLA, were decreased. The LPL activity in adipose tissue was slightly raised. The results suggest that DDVP interferes with the metabolism of lipids.
Kozlowska
A
A
Department of Biochemistry, Medical School, Warsaw, Poland.
Sadurska
B
B
Szymczyk
T
T
D000273:Adipose Tissue / Q000201:enzymology*; D000818:Animals; D004006:Dichlorvos / Q000633:toxicity*; D006493:Heparin / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008066:Lipolysis / Q000187:drug effects*; D008071:Lipoprotein Lipase / Q000032:analysis*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D008055:Lipids; D008074:Lipoproteins; D004006:Dichlorvos; D006493:Heparin; D008071:Lipoprotein Lipase