title: [Manifestation of the mutagenic effect of acemidophen depending on its metabolism in various mammalian species (acemidophen--a promutagen)].
abstract: While studying the specific variability of metabolism of the fasciolacide anthelmintic acemidophen, it is found that it possesses no mutagenic activity. This activity is peculiar to its metabolite-free amine L2, formed in mice organism by deacetylation. Thus, acemidophen is shown to be promutagen.
authors.forename: G N
authors.initials: GN
authors.lastname: Zolotareva
authors.forename: L I
authors.initials: LI
authors.lastname: Khrustaleva
mesh_terms: D000083:Acetanilides / Q000494:pharmacology*; D000588:Amines / Q000493:pharmacokinetics / Q000494:pharmacology / Q000652:urine; D000818:Animals; D000871:Anthelmintics / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000652:urine; D001711:Biotransformation / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002855:Chromatography, Thin Layer; D002869:Chromosome Aberrations; D003957:Diamfenetide / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000652:urine; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009153:Mutagens / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000652:urine; D051381:Rats; D013045:Species Specificity
chemical_list: D000083:Acetanilides; D000588:Amines; D000871:Anthelmintics; D009153:Mutagens; C030572:bis(beta-(4-aminophenoxy)ethyl) ether; D003957:Diamfenetide
vernacular_title: Proiavlenie mutagennogo éffekta atsemidofena v zavisimosti ot ego metabolizma u raznykh vidov mlekopitaiushchikh (atsemidofen--promutagen).