Diurnal effects on debrisoquine hydroxylation phenotyping.
A study was performed to show whether debrisoquine phenotyping could be performed as an overnight procedure. Phenotyping of 33 normal volunteers was carried out during the day and night. A good correlation was observed between the day- and night-time metabolic ratios, although wide variation was observed in 3 subjects.
Lee
E J
EJ
Department of Pharmacology, National University of Singapore.
D000328:Adult; D002940:Circadian Rhythm; D003647:Debrisoquin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine*; D005260:Female; D006801:Humans; D006900:Hydroxylation; D007546:Isoquinolines / Q000378:metabolism* / Q000652:urine*; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic
D007546:Isoquinolines; C012359:4-hydroxydebrisoquin; D003647:Debrisoquin