Serum bile acid concentrations as an indicator of liver dysfunction induced during danazol therapy.
The effects of danazol therapy (600 mg/day) on the liver function of 16 women with endometriosis were investigated. The primary bile acids (cholic acid [CA] and chenodeoxycholic acid [CDCA]) were analyzed with radioimmunoassays in the fasting state and after a test meal. Also, the conventional liver function tests were performed. Ultrasonography was used to detect any possible changes in the gallbladder function. The fasting concentrations of CA increased (P less than 0.05) during therapy, while those of CDCA did not change. The ratio of CA/CDCA also increased (P less than 0.001). The maximal response of CA after the test meal increased (P less than 0.01) during the trial. As regards the other liver function tests, only the transaminases significantly increased (P less than 0.01) after 1 month of therapy but showed a tendency to decrease later during the trial. The gallbladder's volume and function did not change. All the parameters studied normalized within 1 month of cessation of danazol therapy. Danazol seems to have a rather mild effect on liver function. The analyzed parameters indicate transient cell wall injury and slight disturbances in liver cell uptake and secretion mechanism and also of synthesis activity.
Heikkinen
J
J
Department of Obstetrics and Gynaecology, University of Oulu, Finland.
Rönnberg
L
L
Kirkinen
P
P
Sotaniemi
E
E
D000328:Adult; D001647:Bile Acids and Salts / Q000097:blood*; D003613:Danazol / Q000009:adverse effects*; D004715:Endometriosis / Q000188:drug therapy; D005260:Female; D005704:Gallbladder / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008111:Liver Function Tests; D011245:Pregnadienes / Q000009:adverse effects*; D000637:Transaminases / Q000097:blood
D001647:Bile Acids and Salts; D011245:Pregnadienes; D000637:Transaminases; D003613:Danazol