Cytogenetics of unfertilized human oocytes.
During an in-vitro fertilization programme 150 oocytes from 62 women with a mean age of 31 years (range 24-39) remained unfertilized. Successful chromosome analysis was carried out on 96 oocytes by Q-banding: 59 (61.5%) oocytes bore a normal haploid complement, 8 (8.3%) were diploid and 3 (3.1%) tetraploid. In 26 (27.1%) oocytes aneuploidy was observed; these included 9 (9.4%) nullisomic, 5 (5.2%) double nullisomic, 4 (4.2%) triple nullisomic and 2 (2.1%) disomic oocytes. The remaining 54 (36.0%) oocytes could not be evaluated. A nearly uniform rate of aneuploidy was found for unfertilized oocytes among different donor age groups.
Djalali
M
M
Department of Clinical Genetics, University of Ulm, Federal Republic of Germany.
Rosenbusch
B
B
Wolf
M
M
Sterzik
K
K
D000328:Adult; D000782:Aneuploidy; D002874:Chromosome Mapping; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000235:genetics*; D009865:Oocytes / Q000166:cytology*; D011003:Ploidies