title: [Effect of adaptation to hypoxia on the antioxidant enzyme activity in the liver in animals that have undergone stress].
abstract: It was shown in experiments on rats that emotional-painful stress resulted in a rapid increase in malonic dialdehyde (MDA) and in a decrease in the activity of superoxide dismutase (SOD) in liver. Adaptation to moderate intermittent hypoxia in altitude chamber did not affect MDA and increased hepatic SOD by 65%. Stress exposure caused no change in SOD and MDA, but abruptly reduced the fall of SOD in adapted animals. These data are in accordance with the well-known idea that adaptation to hypoxia prevents the activation of lipid peroxidation and the hepatic damage in stress.
authors.forename: V P
authors.initials: VP
authors.lastname: Tverdokhlib
authors.forename: G G
authors.initials: GG
authors.lastname: Konovalova
authors.forename: V Z
authors.initials: VZ
authors.lastname: Lankin
authors.forename: F Z
authors.initials: FZ
authors.lastname: Meerson
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001273:Atmosphere Exposure Chambers; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D000860:Hypoxia / Q000201:enzymology*; D015227:Lipid Peroxidation; D008099:Liver / Q000201:enzymology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000378:metabolism*; D013997:Time Factors
chemical_list: D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase
vernacular_title: Vliianie adaptatsii k gipoksii na aktivnost' antioksidantnykh fermentov v pecheni zhivotnykh, perenesshikh stress.