Immunological subtypes of acute lymphoblastic leukemia in north India.
Pretreatment immunologic marker analysis in 152 adult and childhood patients of ALL and ALL/lymphoma employing multiple monoclonal antibodies and hetero-antisera revealed three major subgroups, i.e. T-ALL (37.7%), N-ALL (33.1%) and C-ALL (21.5%). The early age peak was absent, males predominated in all the subgroups and T-ALL had increased incidence of thymic mass. Leucocyte counts of 50,000 X 10(6)/l were equally frequent in the three groups. T-ALL showed marked heterogeneity by showing a variety of markers such as T-helper/inducer, T-suppressor/cytotoxic, p-24, Ia and CALLA. These results show a high prevalence of unfavourable prognostic factors in ALL in our geographic region which might be related to socioeconomic and/or environmental factors.
Bhargava
M
M
Department of Haematology, All India Institute of Medical Sciences, New Delhi.
Kumar
R
R
Karak
A
A
Kochupillai
V
V
Arya
L S
LS
Mohanakumar
T
T
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007194:India; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000145:classification; D008223:Lymphoma / Q000145:classification; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification* / Q000473:pathology; D012737:Sex Factors
D014408:Biomarkers, Tumor