Preclinical evaluation of the abdominal aortic counterpulsation device.
A valveless, single-orifice abdominal aortic counterpulsation device (AACD) was implanted retroperitoneally on the abdominal aorta and was pumped continuously, providing aortic diastolic augmentation for 45 +/- 4.9 days in four calves (group A). The hematocrit, lactate dehydrogenase (LDH), bilirubin, blood urea nitrogen, and creatinine were obtained before implantation and weekly thereafter. Biocompatibility data were compared to those obtained from 11 calves (group B) that received a total artificial heart (TAH) and were electively terminated 50.0 +/- 19.5 days after implantation. The hematocrit values in the first week were 20.9 +/- 11.5% and 39.8 +/- 11.5% below control values for group A and group B, respectively (p less than 0.02); in the sixth week they were 5.1 +/- 14.6% above control values (group A) and 22.6 +/- 9.0% below control values (group B) (p less than 0.05). LDH did not change in group A, while in group B it was constantly about 100% above control values. Autopsy revealed one to three infarcts 1 to 3 mm in diameter in 63% of the kidneys in group A, while in all of group B kidneys there were multiple infarcts of more than 10 mm. After the induction of left ventricular (LV) failure, the AACD decreased the LV end-diastolic pressure (EDP) by 21.2% (p less than 0.005) and the aortic (AO) EDP by 18% (p less than 0.005). It increased the endocardial viability ratio by 300% (p less than 0.0005), and the cardiac index by 66.9% (p less than 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)
Nanas
J N
JN
Department of Medicine, University of Utah School of Medicine, Salt Lake City 84132.
Mason
J W
JW
Riebman
J B
JB
Charitos
C E
CE
Burns
G L
GL
Olsen
D B
DB
D000818:Animals; D001012:Aorta, Abdominal; D001243:Assisted Circulation; D001663:Bilirubin / Q000097:blood; D001672:Biocompatible Materials; D001806:Blood Urea Nitrogen; D002417:Cattle; D003404:Creatinine / Q000097:blood; D006333:Heart Failure / Q000628:therapy*; D006354:Heart, Artificial; D006353:Heart-Assist Devices; D006400:Hematocrit; D006439:Hemodynamics; D007770:L-Lactate Dehydrogenase / Q000097:blood
D001672:Biocompatible Materials; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D001663:Bilirubin