[Proliferative activity of the hepatocytes at different times of day during prolonged hypokinesia].
The white male Wistar rats were exposed to hypokinesia during 10 days. Essential oppression of the mitotic division of hepatocytes in the rats' liver at the hypokinesia was revealed. The cellular division was exposed to the daily oscillations. The quantity of mitoses prevailed in the day and evening. In these conditions the quantity of binucleate cells increased as compared with the control. The deficit of mitoses stipulates the delay of postnatal weight of liver at the hypokinesia. Binucleate hepatocytes are the analog of the polyploid cells and their large population compensates for the increased organism's need in liver function in the experiment.
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D000818:Animals; D002452:Cell Count; D002455:Cell Division; D002940:Circadian Rhythm; D008099:Liver / Q000166:cytology*; D008297:Male; D008938:Mitosis; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical / Q000009:adverse effects*; D013997:Time Factors
Proliferativnaia aktivnost' gepatotsitov v raznoe vremia sutok v usloviiakh prodolzhitel'noĭ gipokinezii.