title: Failure of penicillin prophylaxis in laboratory acquired leptospirosis.
abstract: A laboratory technician developed leptospirosis following accidental inoculation, despite prompt administration of parenteral penicillin by an accepted regimen of post-exposure prophylaxis. Another technician was similarly exposed and was given doxycycline; no illness or serological conversion followed. The implications of these cases are discussed and recommendations made for post-exposure chemoprophylaxis with doxycycline.
authors.affiliation: St. George's Hospital, London, UK.
authors.forename: C F
authors.initials: CF
authors.lastname: Gilks
authors.forename: H P
authors.initials: HP
authors.lastname: Lambert
authors.forename: E S
authors.initials: ES
authors.lastname: Broughton
authors.forename: C C
authors.initials: CC
authors.lastname: Baker
mesh_terms: D000062:Accidents, Occupational; D000328:Adult; D004318:Doxycycline / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007757:Laboratory Infection / Q000517:prevention & control*; D007921:Leptospira interrogans; D007922:Leptospirosis / Q000517:prevention & control*; D010400:Penicillin G / Q000627:therapeutic use*; D010403:Penicillin Resistance
chemical_list: D004318:Doxycycline; D010400:Penicillin G