title: Angiographic demonstration of atherosclerotic stenosis, arterial spasm, and thrombus formation in an infarct-related coronary artery.
abstract: Clinical, angiographic, and pathologic data support the contention that atherosclerosis, platelet aggregation, and coronary vasomotility work in unison to cause coronary thrombosis, which in turn leads to myocardial infarction. A patient is described in whom, 2 months after an acute myocardial infarction, inducible coronary artery spasm and a nonocclusive thrombus were angiographically demonstrated at the site of a minimal atherosclerotic narrowing in the infarction-related vessel. This report, to the best of our knowledge, is the first time that these three pathophysiologic mechanisms have been shown, in vivo, to be occurring concomitantly in an infarct-related vessel. Documentation of the unified occurrence of these phenomena support the current concept of the pathophysiology of myocardial infarction.
authors.affiliation: Medical Service, VA Medical Center, Miami, FL 33125.
authors.forename: E J
authors.initials: EJ
authors.lastname: de Marchena
authors.forename: R G
authors.initials: RG
authors.lastname: Trohman
authors.forename: A R
authors.initials: AR
authors.lastname: Palomo
authors.forename: R J
authors.initials: RJ
authors.lastname: Myerburg
authors.forename: K M
authors.initials: KM
authors.lastname: Kessler
mesh_terms: D000792:Angiography; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging*; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D003328:Coronary Thrombosis / Q000150:complications / Q000000981:diagnostic imaging*; D003329:Coronary Vasospasm / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*