Trisomy 4 in acute nonlymphocytic leukemia.
Trisomy 4 has recently been identified as a nonrandom chromosomal abnormality associated with acute nonlymphocytic leukemia with myelomonocytic morphology (AML M4). It has been suggested that it may be related to a new type of environmental toxin exposure. During the 1975-1987 period we have detected only one case of simple trisomy 4 in over 1200 patients successfully investigated for hematologic malignancy; this patient was diagnosed as having AML M2 and did not have a history of toxic chemical or drug exposure.
Horsman
D E
DE
Department of Pathology, Cancer Control Agency of British Columbia, Vancouver General Hospital, Canada.
Pantzar
J T
JT
Kalousek
D K
DK
D002894:Chromosomes, Human, Pair 4; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008875:Middle Aged; D014314:Trisomy