Study on the long-term toxic efficacy of cytosine-arabinoside in Sprague-Dawley rats.
This study describes the development of neoplasms and the suppression of bone marrow stem cells following chronic administration of cytosine-arabinoside (ara-C) in Sprague-Dawley rats. Ara-C was administered i.p. either at daily dosages of 5 mg/kg and 25 mg/kg or at pulse doses of three times 500 mg/kg within 1 week followed by a time interval of 11 weeks. The total doses of the higher daily dose and of the pulse dose were chosen to be equally high. No significant carcinogenic activity of ara-C could be assessed following either of these dose schedules. With regard to general toxicity, as expressed by body weight gain and long-term bone marrow toxicity, high pulse doses of ara-C were better or at least equally tolerated as were the equivalent daily low doses.
Berger
M R
MR
Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.
Schmähl
D
D
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003114:Colony-Forming Units Assay; D003561:Cytarabine / Q000633:toxicity*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009369:Neoplasms / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D003561:Cytarabine