Applying the PDR principle to AIDS.
The principle of pathogen-derived resistance (the PDR principle) has been put forward as a broadly-applicable conceptual tool for use in designing genes which will confer resistance to pathogens. This paper reveals an example of how the PDR principle may be applied in the field of human medicine. Specifically it is shown how the PDR principle can be employed in designing a series of genes which should be capable of protecting human blood cells from the retrovirus causing the AIDS disease. Prospects are discussed for using such genes in gene therapy treatment of people infected with this virus.
Sanford
J C
JC
Department of Horticultural Sciences, Cornell University, Geneva, NY 14456.
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000628:therapy*; D004261:DNA Replication; D005814:Genes, Viral; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D012190:Retroviridae / Q000502:physiology; D014158:Transcription, Genetic; D014779:Virus Replication