Does chronic ethanol intake confer full cross-tolerance to chlordiazepoxide?
Four behavioral tests, namely, hypothermia, horizontal dowel, runway and head-dipping, were used to assess tolerance to ethanol and cross-tolerance to chlordiazepoxide (CDP) in mice chronically treated with an ethanol diet for 15 days. Mice were tested on day 3 of ethanol withdrawal, with some being retested on day 8. In terms of hypothermia and the horizontal dowel test, ethanol tolerance conferred full cross-tolerance to CDP, but the conclusion based on results of the latter test may be equivocal. Partial cross-tolerance to CDP was observed in the runway test, while no cross-tolerance to CDP was detected in the head-dipping test. For these latter two tests ethanol tolerance was present in the mice. Thus, the degree of equivalence between tolerance to ethanol and cross-tolerance to CDP in ethanol-dependent mice varied with the behavioral tests to assess tolerance. Possible mechanisms are discussed.
Chan
A W
AW
Research Institute on Alcoholism, New York State Division of Alcoholism and Alcohol Abuse, Buffalo 14203.
Langan
M C
MC
Leong
F W
FW
Schanley
D L
DL
Penetrante
M L
ML
D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D000431:Ethanol; D002707:Chlordiazepoxide