title: Antibacterial effect of etoposide in vitro.
abstract: Etoposide, an antitumor drug, had an effect in vitro against all strains of gram-positive bacteria studied but not against three gram-negative bacteria. The MICs ranged between 6.2 and 50 micrograms/ml. In short-term-growth experiments, etoposide had a bactericidal efficacy that was 10 to 50 times lower than that of cloxacillin.
authors.affiliation: Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Calame
authors.forename: R
authors.initials: R
authors.lastname: van der Waals
authors.forename: N
authors.initials: N
authors.lastname: Douwes-Idema
authors.forename: H
authors.initials: H
authors.lastname: Mattie
authors.forename: R
authors.initials: R
authors.lastname: van Furth
mesh_terms: D005047:Etoposide / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
chemical_list: D005047:Etoposide