Stability of brain incorporation of plasma palmitate in unanesthetized rats of different ages, with appendix on palmitate model.
The unidirectional rate of incorporation of plasma palmitate, Jpalm, was measured in 43 brain regions of unanesthetized male Fischer-344 rats at 3, 12, 24 and 34 months of age. Jpalm was calculated from brain radioactivity 4 h after iv injection of [14C]palmitate, and from the integrated plasma specific activity of palmitate to 4 h. Jpalm was not related significantly to age (P greater than 0.05) in gray and white matter regions, nor was the white/gray ratio for Jpalm related to age (approximating 0.53 at all ages). These results demonstrate age invariance of incorporation of plasma palmitate into stable brain structures of the rat and suggest that turnover of brain lipids also is generally age invariant. A mathematical model for regional incorporation of plasma palmitate is given in an Appendix.
Tabata
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Laboratory of Neurosciences, National Institutes of Health, Bethesda, Maryland 20892.
Kimes
A S
AS
Robinson
P J
PJ
Rapoport
S I
SI
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D003243:Consciousness; D008297:Male; D008954:Models, Biological; D009994:Osmolar Concentration; D010168:Palmitates / Q000097:blood / Q000378:metabolism*; D010169:Palmitic Acids / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344
D010168:Palmitates; D010169:Palmitic Acids