title: The petrous temporal bone and deafness in X-linked hypophosphataemic osteomalacia.
abstract: Radiological anatomy of the petrous bones and skull base has been studied in a group of 11 patients with X-linked hypophosphataemic osteomalacia and hearing loss, and comparison made with a control group of normal subjects. Patients with X-linked hypophosphataemic osteomalacia were found to have generalised osteosclerosis and thickening of the petrous bone, with some narrowing of the internal auditory meatus, particularly in its mid-portion. No evidence of platybasia nor of basilar impression was found in the hypophosphataemmic group. The aetiology of the hearing loss which occurs in patients with X-linked hypophosphataemic osteomalacia is discussed in relation to the radiological abnormalities described.
authors.affiliation: Department of Otolaryngology, Manchester Royal Infirmary.
authors.forename: S P
authors.initials: SP
authors.lastname: O'Malley
authors.forename: J E
authors.initials: JE
authors.lastname: Adams
authors.forename: M
authors.initials: M
authors.lastname: Davies
authors.forename: R T
authors.initials: RT
authors.lastname: Ramsden
mesh_terms: D002875:Chromosomes; D008040:Genetic Linkage; D034381:Hearing Loss / Q000209:etiology*; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000150:complications / Q000000981:diagnostic imaging* / Q000235:genetics; D010018:Osteomalacia / Q000150:complications / Q000000981:diagnostic imaging*; D010579:Petrous Bone / Q000000981:diagnostic imaging*; D011859:Radiography