Comparison of the effects of bifemelane hydrochloride, idebenone and indeloxazine hydrochloride on ischemia-induced depletion of brain acetylcholine levels in gerbils.
Effects of bifemelane hydrochloride, idebenone and indeloxazin hydrochloride on ischemia-induced decrease in acetylcholine (ACh) levels were studied in gerbils. Among these three drugs, only bifemelane hydrochloride significantly inhibited the decrease in ACh concentration in the cerebral cortex, hippocampus and striatum of ischemic gerbils. This suggests that bifemelane hydrochloride has an anti-ischemic action and beneficial effects on various symptoms induced by ischemia.
Ogawa
N
N
Institute for Neurobiology, Okayama University Medical School, Japan.
Haba
K
K
Yoshikawa
H
H
Ono
T
T
Mizukawa
K
K
D000109:Acetylcholine / Q000032:analysis*; D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D016227:Benzoquinones; D001923:Brain Chemistry / Q000187:drug effects*; D002545:Brain Ischemia / Q000378:metabolism*; D002540:Cerebral Cortex / Q000032:analysis; D003342:Corpus Striatum / Q000032:analysis; D005849:Gerbillinae; D006624:Hippocampus / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D009025:Morpholines / Q000494:pharmacology*; D011809:Quinones / Q000494:pharmacology*; D014451:Ubiquinone / Q000031:analogs & derivatives
D001559:Benzhydryl Compounds; D016227:Benzoquinones; D009025:Morpholines; D011809:Quinones; D014451:Ubiquinone; C020852:indeloxazine; C036619:idebenone; D000109:Acetylcholine; C031906:bifemelane