Boreal freshwater fish diet modifies the plasma lipids and prostanoids and membrane fatty acids in man.
The effect of fish diet on 43 healthy male students was studied. They ate a fish-containing meal for 15 weeks on an average of 3.7 times per week. Twenty-one of them voluntarily restricted their lipid intake while the rest ate normally. Controls continued their usual eating habits (19 students). The meals consisted of Finnish freshwater fish (87%) (vendace, pike, perch and rainbow trout) and brackish water fish (13%) (Baltic herring) that provided about 1 g of omega-3 polyunsaturated fatty acids per day (0.25 g eicosapentaenoic acid and 0.55 g docosahexaenoic acid). During the diet, omega-3 fatty acids increased in erythrocyte ghosts and platelets at the expense of omega-6 fatty acids. The concentration of serum cholesterol diminished in those fish consumers who lowered their lipid intake. Apolipoprotein A1 and B were lowered in both fish-consuming groups. Triglyceride levels also showed a tendency to decrease. The formation of thromboxane B2 during incubation of whole blood decreased in both fish-consuming groups. The decrease of plasma 6-keto-PGF1 alpha was not statistically significant, if compared with the controls. The results obtained indicate that a moderate intake of fish-containing meals has some beneficial effects on the plasma lipid and prostanoid metabolism, when coronary heart disease risk factors are considered.
Agren
J J
JJ
Department of Physiology, University of Kuopio, Finland.
Hänninen
O
O
Laitinen
M
M
Seppänen
K
K
Bernhardt
I
I
Fogelholm
L
L
Herranen
J
J
Penttilä
I
I
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000328:Adult; D000818:Animals; D001794:Blood Pressure; D004032:Diet; D005227:Fatty Acids / Q000097:blood*; D005387:Finland; D005396:Fish Products; D005399:Fishes; D005618:Fresh Water; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008563:Membrane Lipids / Q000097:blood*; D011466:Prostanoic Acids / Q000097:blood*; D013929:Thromboxane B2 / Q000097:blood; D014280:Triglycerides / Q000097:blood
D005227:Fatty Acids; D008055:Lipids; D008563:Membrane Lipids; D011466:Prostanoic Acids; D014280:Triglycerides; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha