Mutagenic activity of Mintostachys mollis in AHH1 lymphoblast cells.
Cultured AHH1 human lymphoblast cells were exposed to an extract of Mintostachys mollis, which is used as a medicinal plant and preservative in Peru, to detect its mutagenic activity. A three-day exposure to concentrations of 1, 10, 30 and 50 micrograms/ml resulted in induced mutant fraction of 1.02, 1.79, 2.21 and 3.80 mutations per million cells per day, expressed as 6-Thioguanine resistance. A concentration of 10 micrograms/ml induced 11.9 times the spontaneous mutant fraction of AHH1 cells. The doubling dose determined to be 838 ng/ml. A concentration of 30 micrograms/ml of this compound resembled the induced rate of 1 microM benzo (alpha) pryene.
Carvajal
G
G
Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge 02139.
Thilly
W
W
D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D009152:Mutagenicity Tests; D009153:Mutagens; D010936:Plant Extracts / Q000633:toxicity*; D010945:Plants, Edible
D009153:Mutagens; D010936:Plant Extracts