title: Maternal phenylketonuria: successful outcome in four pregnancies treated prior to conception.
abstract: The management of four pregnancies in two phenylketonuric women is described. A successful outcome in these pregnancies is ascribed to the initiation of treatment prior to conception and the maintenance of tight control with serum phenylalanine between 100 and 400 mumol/l throughout the gestation period. A trial of diet is desirable before a decision is made about pregnancy and before contraception is ceased. Close contact must be maintained with female phenylketonurics throughout their reproductive life to ensure that this process is followed.
authors.affiliation: Phenylketonuria Clinic, Royal Children Hospital, Melbourne, Victoria, Australia.
authors.forename: B C
authors.initials: BC
authors.lastname: Lynch
authors.forename: D B
authors.initials: DB
authors.lastname: Pitt
authors.forename: T G
authors.initials: TG
authors.lastname: Maddison
authors.forename: J E
authors.initials: JE
authors.lastname: Wraith
authors.forename: D M
authors.initials: DM
authors.lastname: Danks
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D010649:Phenylalanine / Q000097:blood; D010661:Phenylketonurias / Q000178:diet therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000178:diet therapy*; D014443:Tyrosine / Q000097:blood
chemical_list: D014443:Tyrosine; D010649:Phenylalanine