A molecular model for proflavine-DNA intercalation.
A molecular model has been derived for the intercalation of proflavine into the CpG site of the decamer duplex of d(GATACGATAC). The starting geometry of the intercalation site was taken from previous crystallographic studies on the d(CpG)-proflavine complex, and molecular mechanics used to obtain a stereochemically acceptable structure. This has widened grooves compared to standard A- or B- double helices, as well as distinct conformational, roll, twist and tilt features.
Neidle
S
S
Cancer Research Campaign Biomolecular Structure Unit, Institute of Cancer Research, Sutton, Surrey, UK.
Pearl
L H
LH
Herzyk
P
P
Berman
H M
HM
D000166:Acridines; D001483:Base Sequence; D004247:DNA / Q000648:ultrastructure*; D007364:Intercalating Agents; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011370:Proflavine; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
D000166:Acridines; D007364:Intercalating Agents; D004247:DNA; D011370:Proflavine