title: The efficacy of ofloxacin against infection caused by Neisseria gonorrhoeae and Chlamydia trachomatis.
abstract: Ofloxacin was used to treat patients with gonorrhoea and/or Chlamydia trachomatis infection. Gonorrhoea was treated with a single 400 mg dose and chlamydial infection with a seven day course (200 mg bd). Fifty of 84 patients with gonorrhoea (60 men and 24 women) returned for two follow-up examinations 7 and 14 days after treatment, 17 patients returned for only one follow-up examination and 17 defaulted. Neisseria gonorrhoeae was re-isolated from three patients who had probably become re-infected. Treatment was successful in 64 patients, 58 of whom were assessed after a single 400 mg dose of ofloxacin. Chlamydial infection was identified in 30 patients with gonorrhoea (13 men and 17 women) and in 35 other patients (17 men and 18 women). C. trachomatis was not recovered from any of the 49 patients who returned for two follow-up examinations, or from the ten patients who attended for one follow-up visit only. Sixteen patients did not return for follow-up examination. Our results suggest a seven day course of ofloxacin would eradicate N. gonorrhoeae and C. trachomatis in patients infected with both organisms. Such treatment may be advisable in patients with gonorrhoea if microbiological tests for C. trachomatis are not available.
authors.affiliation: North Manchester Regional Virus Laboratory, Booth Hall Children's Hospital, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Richmond
authors.forename: M N
authors.initials: MN
authors.lastname: Bhattacharyya
authors.forename: H
authors.initials: H
authors.lastname: Maiti
authors.forename: F H
authors.initials: FH
authors.lastname: Chowdhury
authors.forename: R M
authors.initials: RM
authors.lastname: Stirland
authors.forename: J A
authors.initials: JA
authors.lastname: Tooth
mesh_terms: D002690:Chlamydia Infections / Q000188:drug therapy*; D002692:Chlamydia trachomatis / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006069:Gonorrhea / Q000188:drug therapy*; D008297:Male; D015242:Ofloxacin / Q000627:therapeutic use*
chemical_list: D015242:Ofloxacin