title: Translocation (X;19) with involvement of the inactive X chromosome in oligoblastic granulocytic leukemia.
abstract: A 72-year-old female with metastatic breast cancer developed oligoblastic granulocytic leukemia 6 months after initiation of chemotherapy. Cytogenetic examination of the bone marrow cells revealed a balanced t(X;19)(q12;q13.3) as the sole abnormality in 50% of the metaphases. The remaining cells showed a normal female karyotype. The der(19) chromosome displayed consistent folding in the Xq13-q23 region in all metaphases, indicating involvement of the inactive X chromosome in translocation.
authors.affiliation: Department of Pathology, Medical College of Pennsylvania, Philadelphia.
authors.forename: Z
authors.initials: Z
authors.lastname: Gibas
authors.forename: L M
authors.initials: LM
authors.lastname: Gibas
authors.forename: C A
authors.initials: CA
authors.lastname: Filomena
authors.forename: J
authors.initials: J
authors.lastname: Sprandio
authors.forename: L G
authors.initials: LG
authors.lastname: Jackson
mesh_terms: D000368:Aged; D002888:Chromosomes, Human, Pair 19; D004303:Dosage Compensation, Genetic; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic; D014960:X Chromosome