title: Penetration of nadolol into aqueous humour after a single oral dose.
abstract: Nadolol 20 mg was administered orally as a single-blind, single dose to nine patients about to undergo cataract extraction. Intraocular pressures fell by a mean of 24% 3 h after administration. During the operation, aqueous humour and serum samples were taken for measurement of nadolol concentrations. Aqueous nadolol concentrations ranged from 3.8 to 13.4 ng ml-1, and correlated with the serum drug concentrations (r = 0.84). The fall in intraocular pressure did not correlate with either the aqueous humour or plasma concentrations of nadolol.
authors.affiliation: Warrington District Hospital.
authors.forename: T H
authors.initials: TH
authors.lastname: Tiong
authors.forename: S O
authors.initials: SO
authors.lastname: Hung
authors.forename: M S
authors.initials: MS
authors.lastname: Perelman
mesh_terms: D000284:Administration, Oral; D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009248:Nadolol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011674:Pulse / Q000187:drug effects
chemical_list: D009248:Nadolol