Biovailability and pulmonary first-pass removal of etretinate in rats.
The oral biovailability of etretinate (ET) and its presystemic loss due to pulmonary extraction were studied in the rat. The oral biovailability was found to be 15%. The percentage of a dose of ET escaping pulmonary extraction was estimated to be 49%. These data suggest substantial presystemic loss of ET, including significant extraction by the lungs.
Thongnopnua
P
P
Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis 55455.
Zimmerman
C L
CL
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D005050:Etretinate / Q000378:metabolism / Q000493:pharmacokinetics*; D008168:Lung / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005050:Etretinate