A consensus sequence in the N-terminus of exported proteins: resemblance with metal binding domains and implications in protein translocation across membranes.
By analyzing and comparing the N-terminus of several exported proteins we identified two consensus sequences that resemble metal binding domains. The consensus sequences are part of the signal peptide and part of the adjacent sequences of the mature protein. Three-dimensional modelling of one such domain suggests a conformation with implication in signal peptide insertion.
Tsonis
P A
PA
La Jolla Cancer Research Foundation, Cancer Research Center, CA 92037.
Sowadski
J M
JM
Goetinck
P F
PF
D000595:Amino Acid Sequence; D001665:Binding Sites; D001692:Biological Transport; D002463:Cell Membrane Permeability; D004721:Endoplasmic Reticulum / Q000378:metabolism; D008670:Metals / Q000378:metabolism; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D011506:Proteins / Q000378:metabolism*
D008670:Metals; D011506:Proteins