Patency rate of small caliber fibrous polyurethane vascular prostheses implanted in the dog carotid and femoral artery improved by use of acetylsalicylic acid and dipyridamol.
Segments of 3 mm diameter fibrous polyurethane vascular prosthesis of length 3-4 cm were prepared. They were bilaterally implanted in the carotid and femoral arteries of male and female beagles. Four groups consisting of animals receiving either no medication or thrombocyte aggregation drugs were studied: Group A (8 dogs), no medication: group B (19 dogs), 500 mg acetylsalicylic acid (ASA) once daily and 25 mg dipyridamol (DIP) three times daily orally for 6 weeks after the implantation operation; group C (14 dogs), 250 mg ASA and 25 mg DIP three times daily orally for 6 weeks after the implantation operation; group D (12 dogs), 250 mg ASA and 25 mg DIP three times daily orally for 25 weeks after the implantation operation. Medication was started one week prior to the implantation operation. In group A, all prostheses were occluded at week 6. There was a significant difference in patency rates between groups B-D and C-D. No significant differences in patency rates could be found between groups B and C. The best patency rates were obtained 25 weeks after implantation in group D for both the right and left carotid and right and left femoral implantation sites. Highest patency rates were observed when ASA and DIP were given for 25 weeks.
Hess
F
F
Laboratory for Cell Biology and Histology, Catholic University of Nijmegen, The Netherlands.
Steeghs
S
S
Braun
B
B
van Det
R
R
Grande
P
P
Jerusalem
C
C
Skotnicki
S
S
D000818:Animals; D001241:Aspirin / Q000627:therapeutic use*; D001807:Blood Vessel Prosthesis; D002339:Carotid Arteries / Q000601:surgery*; D004176:Dipyridamole / Q000627:therapeutic use*; D004285:Dogs; D005260:Female; D005263:Femoral Artery / Q000601:surgery*; D006083:Graft Occlusion, Vascular; D008297:Male; D008855:Microscopy, Electron, Scanning; D011140:Polyurethanes; D014654:Vascular Patency / Q000187:drug effects*
D011140:Polyurethanes; D004176:Dipyridamole; D001241:Aspirin