title: Diurnal effects on debrisoquine hydroxylation phenotyping.
abstract: A study was performed to show whether debrisoquine phenotyping could be performed as an overnight procedure. Phenotyping of 33 normal volunteers was carried out during the day and night. A good correlation was observed between the day- and night-time metabolic ratios, although wide variation was observed in 3 subjects.
authors.affiliation: Department of Pharmacology, National University of Singapore.
authors.forename: E J
authors.initials: EJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D002940:Circadian Rhythm; D003647:Debrisoquin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine*; D005260:Female; D006801:Humans; D006900:Hydroxylation; D007546:Isoquinolines / Q000378:metabolism* / Q000652:urine*; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D007546:Isoquinolines; C012359:4-hydroxydebrisoquin; D003647:Debrisoquin