title: Functional and structural alterations of the nervous system induced by avian retrovirus RAV-7.
abstract: Chickens infected as embryos with RAV-7 developed neurological signs including ataxia, lethargy, and imbalance. Evoked spinal cord potentials for RAV-7 infected SC chickens were considerably slower (64.8 m/s) than for uninfected SC (103.4 m/s), genetically hypothyroid (OS) (93.9 m/s) or special C (95.1 m/s) chickens. Conduction velocity measurements of sciatic nerves showed normal values for all the chickens examined in this study. Histopathological studies revealed non-suppurative meningoencephalomyelitis in RAV-7 infected SC chickens. The inflammatory infiltrate consisted of lymphocytes, macrophages, and occasional plasma cells. The cells in the infiltrate reacted with mouse monoclonal antibodies directed against la and T-cell antigens. Astrocytic hypertrophy and hyperplasia, demonstrated by the use of monoclonal antibody specific for glial fibrillary acidic protein (GFAP), was associated with the CNS lesions. The results of this investigation indicate that RAV-7 causes significant central nervous system lesions and functional impairment in the infected chicken. This system may serve as a useful model for studying retrovirus-induced neurological dysfunction.
authors.affiliation: Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523.
authors.forename: L R
authors.initials: LR
authors.lastname: Whalen
authors.forename: D W
authors.initials: DW
authors.lastname: Wheeler
authors.forename: D H
authors.initials: DH
authors.lastname: Gould
authors.forename: S A
authors.initials: SA
authors.lastname: Fiscus
authors.forename: L C
authors.initials: LC
authors.lastname: Boggie
authors.forename: R E
authors.initials: RE
authors.lastname: Smith
mesh_terms: D000818:Animals; D001353:Avian Leukosis / Q000473:pathology / Q000503:physiopathology*; D002493:Central Nervous System Diseases / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D002645:Chickens; D005071:Evoked Potentials; D007150:Immunohistochemistry; D009431:Neural Conduction; D011201:Poultry Diseases / Q000382:microbiology*; D012584:Sciatic Nerve / Q000503:physiopathology; D013116:Spinal Cord / Q000473:pathology / Q000503:physiopathology; D013577:Syndrome