title: Plasma and tissue concentrations of coenzyme Q10 in the rat after intravenous administration by a microsphere delivery system or in a new type of solution.
abstract: Coenzyme Q10 (CoQ10) distribution into rat liver, heart, kidney, and plasma was investigated after intravenous administration in microsphere delivery system and in solution. The liver represented the target organ for this compound in both cases. Higher plasma levels of CoQ10 were achieved after solution treatment. No significant differences were detected in the other tissues examined.
authors.affiliation: Institute of Pharmacology, School of Medicine, University of Pisa, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Alessandrì
authors.forename: V
authors.initials: V
authors.lastname: Scalori
authors.forename: L
authors.initials: L
authors.lastname: Giovannini
authors.forename: M
authors.initials: M
authors.lastname: Mian
authors.forename: A A
authors.initials: AA
authors.lastname: Bertelli
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003067:Coenzymes; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008863:Microspheres; D009206:Myocardium / Q000378:metabolism; D009994:Osmolar Concentration; D011092:Polyethylene Glycols; D051381:Rats; D011919:Rats, Inbred Strains; D012996:Solutions; D013997:Time Factors; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D003067:Coenzymes; D012996:Solutions; D014451:Ubiquinone; D011092:Polyethylene Glycols; C024989:coenzyme Q10; C018557:glycofurol