The handling of NaCl load in rats during DOCA-salt and Goldblatt 2 kidney-1 clip hypertension development.
The handling of an intraperitoneal NaCl load (2% body weight, 0.9% NaCl) administered twice a week during DOCA-salt and Goldblatt 2K-1C hypertension development has been evaluated. An exaggerated natriuresis was observed in DS-hypertensive rats since blood pressure became higher with respect to normal (C), Doca (D) and uninephrectomized-salt (NS) rats that served as controls. However, this phenomenon was not observed in Goldblatt 2K-1C hypertensive rats (2K-1C) when compared to the response obtained in sham-operated (SO) rats. These results suggest that: 1) An increased blood pressure, per se, is not a determinating factor for exaggerated natriuresis. 2) Rise in blood pressure and exaggerated natriuresis may be related through a common mechanism in Doca-salt hypertension.
Vargas
F
F
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Granada, Spain.
Casanova
I
I
Haro
J M
JM
Luna
J D
JD
García del Río
C
C
D000818:Animals; D003900:Desoxycorticosterone; D004231:Diuresis; D006973:Hypertension / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D006978:Hypertension, Renovascular / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D008026:Ligation; D008297:Male; D009318:Natriuresis; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000378:metabolism*; D013997:Time Factors
D003900:Desoxycorticosterone; D012965:Sodium Chloride