title: Treated blood pressure, rather than pretreatment, predicts survival in hypertensive patients. A report from the DHSS Hypertension Care Computing Project (DHCCP).
abstract: A group of hypertensive patients (n = 2855) with an untreated diastolic blood pressure greater than or equal to 90 mmHg were followed in the Department of Health and Social Security (DHSS) Hypertension Care Computing Project (DHCCP) for periods of up to 10 years. During this period 191 of these patients died. Survival was assessed in relation to pretreatment blood pressure levels and blood pressure achieved during treatment. The blood pressure during treatment was a useful predictor of mortality, but the pretreatment pressure was not. After adjusting for age, mortality was particularly related to the height of the systolic and diastolic blood pressure during the second and third years of treatment. In men, age-standardized 5-year mortality was greater than 10% in those with a first year treated systolic pressure greater than 150 mmHg or a diastolic pressure greater than 95 mmHg. In women, age standardized 5-year mortality was greater than 5% with the same levels of treated blood pressure. The longest survival occurred with the lowest bands of treated pressure, i.e. systolic pressure less than 140 and diastolic pressure less than 90 mmHg; the 5-year mortality being less than 7% in men and less than 3% in women. Treated systolic and diastolic pressures were useful in predicting death from ischaemic heart disease (IHD).
authors.affiliation: Hammersmith Hospital, London, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Bulpitt
authors.forename: D G
authors.initials: DG
authors.lastname: Beevers
authors.forename: A
authors.initials: A
authors.lastname: Butler
authors.forename: E C
authors.initials: EC
authors.lastname: Coles
authors.forename: A E
authors.initials: AE
authors.lastname: Fletcher
authors.forename: D
authors.initials: D
authors.lastname: Hunt
authors.forename: A D
authors.initials: AD
authors.lastname: Munro-Faure
authors.forename: R
authors.initials: R
authors.lastname: Newson
authors.forename: P W
authors.initials: PW
authors.lastname: O'Riordan
authors.forename: J C
authors.initials: JC
authors.lastname: Petrie
mesh_terms: D001794:Blood Pressure; D005260:Female; D006801:Humans; D006973:Hypertension / Q000401:mortality* / Q000628:therapy; D008297:Male