title: Single-dose prophylaxis with cefotetan in elective abdominal surgery. A controlled trial.
abstract: Single dose cefotetan was compared with either a combination of metronidazole and cefazolin given for 24 hours or 3 doses of cefuroxime as prophylaxis in elective abdominal surgery. Wound infections and infections at remote sites (UTI and RTI) were similar in all groups. In a third group prophylaxis of abdominal surgery using a single 2g dose of cefotetan was compared to 2 doses of the same drug, given 12 hours apart. There was no demonstrable advantage to giving 2 doses. The low incidence of post-operative infections seen in all groups indicates the efficacy of cefotetan in the surgical prophylaxis of elective abdominal surgery.
authors.affiliation: Academic Hospital, Leuven, Belgium.
authors.forename: J A
authors.initials: JA
authors.lastname: Gruwez
authors.forename: J
authors.initials: J
authors.lastname: Lerut
authors.forename: M R
authors.initials: MR
authors.lastname: Christiaens
authors.forename: J
authors.initials: J
authors.lastname: De Roose
authors.forename: L
authors.initials: L
authors.lastname: Vernimmen
authors.forename: J
authors.initials: J
authors.lastname: Hendrickx
authors.forename: F
authors.initials: F
authors.lastname: Trimpeneers
authors.forename: H
authors.initials: H
authors.lastname: Schroé
authors.forename: M
authors.initials: M
authors.lastname: Deruyter
authors.forename: K J
authors.initials: KJ
authors.lastname: Williams
mesh_terms: D000005:Abdomen / Q000601:surgery*; D002437:Cefazolin / Q000008:administration & dosage; D015313:Cefotetan / Q000008:administration & dosage*; D002444:Cefuroxime / Q000627:therapeutic use; D003106:Colon / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage; D011292:Premedication; D012007:Rectum / Q000601:surgery; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D008795:Metronidazole; D015313:Cefotetan; D002437:Cefazolin; D002444:Cefuroxime