Modifications of the sexual activity in male rats following administration of antiserotoninergic drugs.
The influence of cyproheptadine (CPH), methysergide and 5-hydroxytryptamine (5-HT) was studied on male sexual activity. Wistar rats from a colony of the Department were used. Measures of sexual parameters (number of ejaculations, initial latency, ejaculation latency, refractory period and neuromotor activity) indicate that cyproheptadine and methysergide facilitate male sexual activity. However, 5-HT inhibits male sexual reflex. Our experimental results suggest that the serotoninergic system exerts an inhibitory role on the sexual parameters which comprise the copulatory model of the male rat and also demonstrate that cyproheptadine facilitates sexual behavior of the male rat.
Menéndez Abraham
E
E
Departamento de Biologiía Funcional (Fisiología), Universidad de Oviedo, Spain.
Morán Viesca
P
P
Velasco Plaza
A
A
Marín
B
B
D000818:Animals; D001143:Arousal / Q000187:drug effects; D003307:Copulation / Q000187:drug effects; D003533:Cyproheptadine / Q000494:pharmacology; D004542:Ejaculation / Q000187:drug effects; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D012702:Serotonin Antagonists; D003533:Cyproheptadine; D012701:Serotonin; D008784:Methysergide