Assessment of plasma leukotriene and prostaglandin levels during adjuvant arthritis and kaolin-induced paw oedema in rats.
Plasma levels of some arachidonic acid metabolites were investigated in acute and chronic models of inflammation in rats. As a model of chronic inflammation, adjuvant arthritis in rats induced by the injection of Freund's complete adjuvant, and as an acute model for inflammation, kaolin-induced paw oedama were used. Plasma leukotriene(LT) C4-like and prostaglandin(PG) E2-like activities were quantitated by bioassay in guinea-pig ileum and rat stomach fundus respectively. In the course of adjuvant arthritis, plasma levels of LTC4- and PGEi2-like activities were increased. Plasma LTC4-like activity reached a maximum within 3 weeks, while PGE2-like activity reached a maximum 10 days after adjuvant injection. In the early phase of adjuvant arthritis, levels of both LTC4- and PGE2-like activities were found to be low but both activities were increased in the late phase of inflammation.
Melli
M
M
Department of Pharmacology, Faculty of Medicine, University of Ankara, Turkey.
D000818:Animals; D001168:Arthritis / Q000097:blood*; D001169:Arthritis, Experimental / Q000097:blood*; D001681:Biological Assay; D015232:Dinoprostone / Q000097:blood; D004487:Edema / Q000097:blood* / Q000139:chemically induced; D005748:Gastric Fundus / Q000187:drug effects; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D007616:Kaolin; D051381:Rats; D013189:SRS-A / Q000097:blood*
D013189:SRS-A; D007616:Kaolin; D015232:Dinoprostone