title: A longitudinal study of cholesterol metabolism in familial hypercholesterolemia.
abstract: Sterol balance studies were performed in 11 patients with familial hypercholesterolemia before and after a 15-year follow-up exactly under the same conditions to evaluate whether ageing exerts any changes on serum lipids and cholesterol metabolism. No significant intraindividual variation could be observed in serum lipids, bile acid and cholesterol synthesis and cholesterol excretion as neutral sterols and no age-related association could be observed in these parameters.
authors.affiliation: Second Department of Medicine, University of Helsinki, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Gylling
authors.forename: T A
authors.initials: TA
authors.lastname: Miettinen
mesh_terms: D000328:Adult; D000375:Aging / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000378:metabolism*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D013261:Sterols / Q000378:metabolism; D013997:Time Factors
chemical_list: D001647:Bile Acids and Salts; D013261:Sterols; D002784:Cholesterol