title: A stochastic two-stage model for cancer risk assessment. I. The hazard function and the probability of tumor.
abstract: We present a mathematical treatment of a two-mutation model for carcinogenesis with time-dependent parameters. This model has previously been shown to be consistent with epidemiologic and experimental data. An approximate hazard function used in previous papers is critically evaluated.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
authors.forename: S H
authors.initials: SH
authors.lastname: Moolgavkar
authors.forename: A
authors.initials: A
authors.lastname: Dewanji
authors.forename: D J
authors.initials: DJ
authors.lastname: Venzon
mesh_terms: D002273:Carcinogens; D003043:Cocarcinogenesis; D006801:Humans; D015233:Models, Statistical; D009369:Neoplasms / Q000209:etiology; D012306:Risk; D013269:Stochastic Processes
chemical_list: D002273:Carcinogens