[Action of doxorubicin and a doxorubicin-heparin complex on the growth and metastasis of experimental tumors and the hemostatic system indices].
The electrophoretic and spectral analyses have been used to show the possibility to form a complex consisting of doxorubicin and adriamycin with heparin, the molar ratio being 6:1 and pH 4.8-7.4. Doxorubicin and adriamycin had procoagulant properties but the doxorubicin-heparin complex showed an anticoagulant activity. In experiments on rats with the Pliss lymphosarcoma and sarcoma 45 the doxorubicin-heparin complex depressed more efficiently the tumour growth and metastasis spreading. The combination of doxorubicin and the doxorubicin heparin complex with the trypsin-heparin complex which imitate the hyperfunction of anticoagulative system markedly increased the antitumour effects.
Kalishevskaia
T M
TM
Bashkov
G V
GV
Repina
N Iu
NIu
Shpilevaia
M V
MV
Modina
L S
LS
D000818:Animals; D004317:Doxorubicin / Q000627:therapeutic use*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D006487:Hemostasis / Q000187:drug effects*; D006493:Heparin / Q000627:therapeutic use*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000188:drug therapy / Q000556:secondary; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000097:blood / Q000188:drug therapy* / Q000556:secondary; D051381:Rats; D012513:Sarcoma, Experimental / Q000097:blood / Q000188:drug therapy / Q000556:secondary; D013997:Time Factors
D004338:Drug Combinations; D004317:Doxorubicin; D006493:Heparin
Deĭstvie doksorubitsina i kompleksa doksorubitsin--geparin na rost i metastazirovanie éksperimental'nykh opukholeĭ i nekotorye pokazateli sistemy gemostaza.