Translocation t(11;19)(q21;p13.1) as the sole chromosome abnormality in a cystadenolymphoma (Warthin's tumor) of the parotid gland.
Cytogenetic findings on a cystadenolymphoma (Warthin's tumor) of the parotid gland are reported. In the primary culture, a reciprocal balanced translocation t(11;19)(q21;p13.1) as the sole clonal abnormality was found in the majority of metaphases. At this time, the proliferation of epithelial cells was observed in the cultures. Later passages showed overgrowing fibroblasts, and the abnormal metaphases disappeared. This result should stimulate further efforts for cytogenetic investigations of the epithelial part and permit a better understanding of the histogenesis of this particular tumor.
Bullerdiek
J
J
Centre of Human Genetics, University of Bremen, West Germany.
Haubrich
J
J
Meyer
K
K
Bartnitzke
S
S
D000235:Adenolymphoma / Q000235:genetics*; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D002888:Chromosomes, Human, Pair 19; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic