[Treatment of experimental destruction of the duodenum with preparations with nootropic action].
In the experiments on rats the peptic ulcer of duodenum was simulated by means of mechanic compression of reflexogenic zones of pylorus and intestine. The destruction of duodenal mucosa was developed in 3-4 hours after the compression and retained in the course of 5-6 days. Piracetam (200 mg/kg) and etimizol (3 mg/kg) eliminated and cimetidine (25 mg/kg), solcoseryl (0.5 mg/kg) and metacine (5 mg/kg) diminished the destruction after the course of 6 injections of each drug with an interval of 10-12 hours. Therapeutic effects of piracetam and etimizol correlated with their ability to return towards normal concentration of creatine phosphate.
Buliusin
V Ia
VIa
Nilova
T N
TN
Shabanov
P D
PD
D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000378:metabolism; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors
D011619:Psychotropic Drugs; D010725:Phosphocreatine
Lechenie éksperimental'nykh destruktsiĭ dvenadtsatiperstnoĭ kishki preparatami nootropnogo deĭstviia.