Octahedral complexes of anti-cancer Pt(IV)(cyclohexyldiamine) agents with 9-methylguanine.
The compounds [Pt(IV)(dach)(9-methylguanine)2X2]2+ (X = Cl, OH) have been prepared and structurally characterized. Their existence shows that it is possible to accommodate two purine bases (in a cis configuration) and four other ligands around a Pt(IV) atom. The geometries of these complexes have very different orientations of the guanine rings as compared to their corresponding Pt(II) counterparts.
Choi
H K
HK
Department of Chemistry, University of Southern California, Los Angeles 90089-0744.
Huang
S K
SK
Bau
R
R
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002614:Chelating Agents; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006151:Guanosine / Q000031:analogs & derivatives*; D008961:Models, Structural; D009944:Organoplatinum Compounds / Q000138:chemical synthesis*
D000970:Antineoplastic Agents; D002614:Chelating Agents; D009944:Organoplatinum Compounds; C057643:dichlorocyclohexyldiamine-9-methylguanine platinum IV; C057642:cyclohexyldiamine-9-methylguanine platinum IV; D006151:Guanosine; D006147:Guanine