title: Protein requirements of infants: a reexamination of concepts and approaches.
abstract: Estimates of protein requirements of infants aged 3-4 mo by FAO/WHO/UNU (1.47 +/- 0.26 g.kg-1.d-1 as crude protein, N X 6.25) are judged to be overestimates. From simulation analyses we suggest that 1.1 +/- 0.1 - 0.2 g.kg-1.d-1 is a more reasonable estimate. This is consistent with statements that 1) breast milk that provides an average of 16 g protein/1000 kcal or a fixed-composition formula that contains 17 g protein/1000 kcal is adequate for essentially all such infants and 2) average protein intakes from that milk or formula would be approximately 1.65 or 1.75 g.kg-1.d-1, close to current average requirements estimates. It appears that there has been a difference in the concepts of requirement usually applied to infants and to adults and a systematic misinterpretation of breast-milk data in estimating requirements. A plea is issued for the application of epidemiologic approaches as a part of requirement estimation.
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada.
authors.forename: G H
authors.initials: GH
authors.lastname: Beaton
authors.forename: A
authors.initials: A
authors.lastname: Chery
mesh_terms: D004044:Dietary Proteins; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D008722:Methods; D008894:Milk Proteins / Q000032:analysis; D008895:Milk, Human / Q000032:analysis; D009751:Nutritional Requirements
chemical_list: D004044:Dietary Proteins; D008894:Milk Proteins