title: Rifampin activity against Staphylococcus epidermidis biofilms.
abstract: Rifampin has demonstrated remarkable antimicrobial activity against Staphylococcus epidermidis biofilms. Four other antibiotics had no effect when used alone; three of these (clindamycin, gentamicin, and tetracycline) were antagonistic to rifampin when used in combination. Vancomycin was synergistic with rifampin, producing complete killing. Fresh peritoneal dialysis (PD) solution accentuated the antimicrobial activity, whereas spent PD fluid neutralized it.
authors.affiliation: Department of Medicine, Montreal General Hospital, McGill University, Quebec, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Obst
authors.forename: R F
authors.initials: RF
authors.lastname: Gagnon
authors.forename: J
authors.initials: J
authors.lastname: Prentis
authors.forename: G K
authors.initials: GK
authors.lastname: Richards
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001422:Bacterial Adhesion; D015314:Dialysis Solutions / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology; D006801:Humans; D010531:Peritoneal Dialysis, Continuous Ambulatory; D012293:Rifampin / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000502:physiology; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D015314:Dialysis Solutions; D013752:Tetracycline; D012293:Rifampin