title: In vitro evaluation of iris chafe protection afforded by hydrophilic surface modification of polymethylmethacrylate intraocular lenses.
abstract: An in vitro iris chafe test was developed to evaluate possible differences in abrasive interaction of various intraocular lens (IOL) materials with the posterior surface of the iris. The materials that were compared in initial tests with rabbit irides were high molecular weight polymethylmethacrylate (PMMA), the primary IOL material in current use, and surface-modified PMMA, which had a permanent, chemically bound, hydrophilic, polymer surface. Scanning electron microscopy, light microscopy, and examination of histological sections were used to assess tissue damage. A "window defect" type of abrasive damage was observed by light microscopy for PMMA lenses and is very similar in appearance to that seen for iris abrasion by human implants when viewed in vivo in slitlamp examinations. Results for both pigmented and albino rabbit irides indicate a reduction in abrasive insult to the external iris basement membrane and underlying pigment epithelium by the hydrophilic surface modification of PMMA. These results are consistent with our observation of a major reduction in corneal endothelium damage on contact with the hydrophilic surface-modified PMMA as compared with PMMA itself. This in vitro iris abrasion test, therefore, appears to be a useful technique for future evaluation of IOL surface properties.
authors.affiliation: Department of Materials Science, University of Florida, Gainesville 32611.
authors.forename: F M
authors.initials: FM
authors.lastname: Hofmeister
authors.forename: M S
authors.initials: MS
authors.lastname: Yalon
authors.forename: S
authors.initials: S
authors.lastname: Iida
authors.forename: M D
authors.initials: MD
authors.lastname: Goldberg
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D066298:In Vitro Techniques; D007498:Iris / Q000293:injuries* / Q000648:ultrastructure; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008422:Materials Testing / Q000295:instrumentation; D008768:Methylmethacrylates; D008855:Microscopy, Electron, Scanning; D011108:Polymers; D011817:Rabbits; D013314:Stress, Mechanical; D013499:Surface Properties; D014950:Wounds, Penetrating / Q000517:prevention & control*
chemical_list: D008768:Methylmethacrylates; D011108:Polymers