A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons.
Thirty-five genes define a pathway for the development of the hermaphrodite-specific neurons (HSNs) in Caenorhabditis elegans. Some of these genes affect only one HSN trait, demonstrating that HSN migration, axonal outgrowth and serotonin expression are mutually independent events in HSN development; others, some of which are regulatory, affect multiple HSN traits. Nearly all are pleiotropic, revealing that the genes specifying HSN development also function in the development of other cell types.
Desai
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Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
Garriga
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McIntire
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Horvitz
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HR
D000818:Animals; D001369:Axons / Q000502:physiology; D002107:Caenorhabditis / Q000196:embryology* / Q000235:genetics; D012734:Disorders of Sex Development; D005796:Genes; D009046:Motor Neurons / Q000502:physiology*; D009154:Mutation; D010641:Phenotype; D012701:Serotonin / Q000502:physiology; D012737:Sex Factors
D012701:Serotonin