[Mechanisms of the regulation of membrane receptor activity by synthetic antioxidants of the screened phenol class].
The influence of synthetic water-soluble phenol antioxidants, phenosan and the potassium salt of phenosan (phenosan-K), on the signal processing in some membrane receptor systems of the rat brain has been studied. It was demonstrated that these compounds act at the level transmembrane signal processing rather than at the level of ligand-receptor complex formation. The influence of phenosan and phenosan-K on the activity of brain receptors being due to antioxidants interaction with a hydrophobic moiety of these receptors or the action of antioxidants on the second messengers system. It is proposed that this in vitro action of phenol antioxidants, at concentrations exceeding 10 mcM, is a result of the antioxidant's non-specific interaction with cell plasma membranes and alteration of physicochemical properties of membrane lipids caused by these inhibitors of free radical reactions.
Kokhlov
A P
AP
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects; D050356:Lipid Metabolism; D010636:Phenols / Q000494:pharmacology*; D011494:Protein Kinases / Q000378:metabolism; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects*
D000975:Antioxidants; D010636:Phenols; D011494:Protein Kinases
Mekhanizmy reguliatsii aktivnosti membrannykh retseptorov sinteticheskimi antioksidantami iz klassa ékranirovannykh fenolov.