Anticonvulsive properties of pregnanolone emulsion compared with althesin and thiopentone in mice.
The anticonvulsive properties of pregnanolone (as an emulsion) were evaluated in mice and compared with similar properties of Althesin and thiopentone. Pregnanolone emulsion was found to antagonize convulsions induced by the GABA antagonists pentetrazole, bicuculline and picrotoxin and by the specific glycine receptor antagonist, strychnine. The drug was effective in all four convulsive tests at subanaesthetic doses with maximal activity appearing within less than 1 min. The anticonvulsive therapeutic indices of pregnanolone emulsion were superior when compared with the therapeutic indices of Althesin and thiopentone in all four tests. Pregnanolone emulsion might be a useful alternative drug in the management of convulsive states resistant to conventional therapy.
Høgskilde
S
S
Department of Anaesthesiology and Intensive Care, Municipal Hospital of Copenhagen, Denmark.
Wagner
J
J
Carl
P
P
Anker
N
N
Angelo
H R
HR
Sørensen
M B
MB
D000530:Alfaxalone Alfadolone Mixture / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants; D004353:Drug Evaluation, Preclinical; D004655:Emulsions; D008297:Male; D051379:Mice; D011278:Pregnanes / Q000494:pharmacology*; D011280:Pregnanolone / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D012640:Seizures / Q000188:drug therapy; D013874:Thiopental / Q000494:pharmacology*
D000927:Anticonvulsants; D004655:Emulsions; D011278:Pregnanes; D000530:Alfaxalone Alfadolone Mixture; D011280:Pregnanolone; D013874:Thiopental