[Possible mechanism of the alteration in the therapeutic action of cyclophosphane in mice with hemocytoblastosis La against a background of artificial hyperglycemia].
The concentration of reactive cyclophosphamide metabolites (CP) and the time of their circulation in blood plasma of mice increase during artificial hyperglycemia (HG). Intensification of the antitumor CP activity against a background of HG in C57Bl/6 mice with hemocytoblastosis La may be a result of changes in the drug pharmacokinetics. An inhibitory action of HG on the CP-metabolizing system of the liver monooxygenases is shown.
Kabieva
A O
AO
Donenko
F V
FV
D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D003520:Cyclophosphamide / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005947:Glucose / Q000008:administration & dosage*; D007942:Leukemia, Experimental / Q000097:blood / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D013997:Time Factors
D001786:Blood Glucose; D003520:Cyclophosphamide; D005947:Glucose
Vozmozhnyĭ mekhanizm izmeneniia lechebnogo deĭstviia tsiklofosfana u mysheĭ s gemotsitoblastozom La na fone iskusstvennoĭ giperglikemii.