title: Noradrenaline excites neurons in the guinea pig cerebellar vermis in vitro.
abstract: Noradrenaline (NA) was applied to the solution bathing the cavy cerebellar vermis in vitro and the responses of 98 neurons were recorded extracellularly. Two thirds (23/35) of the responses were excitations and the remaining third were inhibitions. The lowest concentration of NA with which responses could be obtained was 10(-11) M NA. Responses were generally transient and occurred with a mean latency of 61 +/- 8 sec. The excitation was generally direct as most responses (9/11) survived synaptic blockade. The excitations were thought to be mediated by alpha 1 receptors because they could be mimicked by phenylephrine and antagonised by prazozin.
authors.affiliation: Department of Physiology, Otago Medical School, Dunedin, New Zealand.
authors.forename: E R
authors.initials: ER
authors.lastname: Dennett
authors.forename: J I
authors.initials: JI
authors.lastname: Hubbard
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000187:drug effects* / Q000502:physiology; D004594:Electrophysiology; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008729:Methoxamine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology*; D010656:Phenylephrine / Q000494:pharmacology
chemical_list: D010656:Phenylephrine; D008729:Methoxamine; D009638:Norepinephrine