Neutrophil function in patients with localized juvenile periodontitis and with rapidly progressive periodontitis.
PMN chemotactic function and oxydative metabolism were investigated in 13 patients with rapidly progressive periodontitis (RPP) and 9 patients with localized juvenile periodontitis (LJP) using a chemotaxis assay (CHA), luminol chemiluminescence (CL) and nitroblue-tetrazolium (NBT) tests. In the LJP patients there was a significantly lower CHA than in the RPP patients (less than 40%). Three out of the 13 RPP patients displayed a cell-dependent increase of CHA and in 3, the reduced CHA measured was serum-associated whilst among the 9 LJP patients, a cell-dependent defect of CHA was present in 5 patients, a serum-associated defect in one patient and a combined cell- and serum-associated defect was found in another patient. The average values of CL in the RPP patients were significantly lower (1309.3 +/- 814.2) than those measured in the LJP group (2208 +/- 826.9). In contrast, the mean NBT test values indicated a lower phagocytic function in the LJP patients than in the RPP ones suggesting also the presence of a serum-dependent factor in RPP and that of a combined cell- and serum-response in LJP. According to these results, the neutrophil dysfunction in RPP, as indicated by both the chemotaxis and the oxydative metabolism nature, was frequently associated with a serum factor.
Zafiropoulos
G G
GG
Department of Periodontology, Philipps University of Marburg, School of Dental Medicine, F. R. Germany.
Flores-De-Jacoby
L
L
Czerch
W
W
Kolb
G
G
Markitziu
A
A
Havemann
K
K
D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000097:blood* / Q000503:physiopathology; D002634:Chemotaxis, Leukocyte; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008163:Luminescent Measurements; D008297:Male; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D009580:Nitroblue Tetrazolium; D010084:Oxidation-Reduction; D010510:Periodontal Diseases / Q000097:blood*; D010518:Periodontitis / Q000097:blood* / Q000503:physiopathology
D009580:Nitroblue Tetrazolium