Fructose-1,6-diphosphate reduces acute ECG changes due to doxorubicin in isolated rat heart.
Doxorubicin (DXR) (0.17 x 10(-4) M) induces an acute cardiotoxicity in isolated rat heart; there is a progressive widening of the S alpha T segment, with a decrease in force derivatives and in the coronary flow. Concurrent perfusion with fructose-1,6-diphosphate (FDP) (10(-5)-10(-4) M) dose-dependently reduces the S alpha T enlargement but fails to affect the reduction in force derivatives and coronary flow. The target of cardiac protection by FDP might be the ionic mechanisms underlying the action potential configuration.
Bernardini
N
N
Institute of Medical Pharmacology, Pisa University, Italy.
Danesi
R
R
Bernardini
M C
MC
Del Tacca
M
M
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology / Q000633:toxicity*; D004562:Electrocardiography; D005260:Female; D005635:Fructosediphosphates / Q000494:pharmacology*; D006331:Heart Diseases / Q000139:chemically induced* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006598:Hexosediphosphates / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D005635:Fructosediphosphates; D006598:Hexosediphosphates; D004317:Doxorubicin; C029063:fructose-1,6-diphosphate