[Synthesis of DNA in dividing and quiescent cells following gamma-irradiation].
Changes in clonogenic capacity of gamma-irradiated minimally transformed 3T3 cells (Do = 1.3 Gy, D37 = 5 Gy, and Dq = 5.3 Gy) were determined and conditions for obtaining dormant population of these cells were chosen to be adequate for registering the radiation-induced unscheduled DNA synthesis. The comparison between the postirradiation changes in DNA synthesis in dividing and resting 3T3 cells suggests the participation of DNA-polymerase alpha in providing the unscheduled DNA synthesis in resting cells after gamma-irradiation with doses of 5 to 50 Gy.
Bezlepkina
T A
TA
Ostrovskaia
L B
LB
Bezlepkin
V G
VG
Gaziev
A I
AI
D000818:Animals; D002455:Cell Division / Q000528:radiation effects*; D002461:Cell Line, Transformed; D002470:Cell Survival / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D004247:DNA / Q000096:biosynthesis*; D004257:DNA Polymerase II / Q000378:metabolism; D005720:Gamma Rays; D066298:In Vitro Techniques; D051379:Mice
D003037:Cobalt Radioisotopes; D004247:DNA; D004257:DNA Polymerase II
Sintez DNK v deliashchikhsia i pokoiashchikhsia kletkakh posle gamma-oblucheniia.