Enhanced murine respiratory tract IgA antibody response to oral influenza vaccine when combined with a lipoidal amine (avridine).
The adjuvant activity of avridine, a synthetic lipoidal amine, incorporated in liposomes, was studied in mice immunized orally with killed influenza virus vaccine (A/PR/8/34, H1N1). Coadministration of avridine-containing liposomes and viral antigen enhanced the remote-site IgA antibody response in the respiratory tract without a concomitant serum antibody response or side effects. The results support the possible use of mucosal adjuvants for oral immunization against respiratory pathogens.
Bergmann
K C
KC
Karl-Hansen-Klinik, Bad Lippspringe, FRG.
Waldman
R H
RH
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology*; D003959:Diamines / Q000008:administration & dosage*; D004338:Drug Combinations; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007252:Influenza Vaccines / Q000008:administration & dosage*; D051379:Mice; D008807:Mice, Inbred BALB C
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D003959:Diamines; D004338:Drug Combinations; D007070:Immunoglobulin A; D007252:Influenza Vaccines; C006270:avridine