title: The diagnosis of venogenic impotence: dynamic or pharmacologic cavernosometry?
abstract: In an attempt to refine the diagnosis of venogenic impotence, we evaluated different techniques of cavernosometry in 10 dogs. Saline was perfused intracavernously in five dogs to induce erection. Regardless of the amount required for induction, a mean flow rate of 23.4 ml./min. was necessary to maintain an intracavernous pressure level of 110 cm. H2O. In seven dogs, a leak was created by intracavernous insertion of a 19-gauge needle. When erection was induced by either cavernous nerve stimulation or a combination of papaverine injection and saline perfusion, the mean flow through the needle was significantly less than when erection was induced by saline perfusion alone (1.73, 1.78, and 8.77 ml./min., respectively). Sympathetic trunk stimulation at the level of L5 could reduce the intracavernous pressure by 90% in erections induced by neural stimulation or papaverine plus perfusion but had no effect on erection induced by saline perfusion alone. Our findings show that cavernosometry after intracavernous injection of papaverine will provide more valuable information in patients in whom venogenic impotence is suspected.
authors.affiliation: Department of Urology, University of California, San Francisco 94143.
authors.forename: C G
authors.initials: CG
authors.lastname: Stief
authors.forename: W
authors.initials: W
authors.lastname: Diederichs
authors.forename: F
authors.initials: F
authors.lastname: Benard
authors.forename: R
authors.initials: R
authors.lastname: Bosch
authors.forename: T F
authors.initials: TF
authors.lastname: Lue
authors.forename: E A
authors.initials: EA
authors.lastname: Tanagho
mesh_terms: D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D007172:Erectile Dysfunction / Q000503:physiopathology*; D008297:Male; D008722:Methods; D010208:Papaverine / Q000008:administration & dosage; D010410:Penile Erection / Q000187:drug effects; D010413:Penis / Q000503:physiopathology*; D011312:Pressure; D012965:Sodium Chloride / Q000008:administration & dosage; D013564:Sympathetic Nervous System / Q000502:physiology; D014680:Veins / Q000503:physiopathology*
chemical_list: D012965:Sodium Chloride; D010208:Papaverine