title: Acute nonlymphocytic leukemia following short-term, intermittent, intravenous cyclophosphamide treatment of lupus nephritis.
abstract: Intermittent intravenous cyclophosphamide therapy has been shown to be effective in the management of lupus nephritis. There have been no reports of malignancies associated with such treatment regimens. We describe a patient who developed acute nonlymphocytic leukemia after receiving a total dose of 4 gm of cyclophosphamide over a 1-year period.
authors.affiliation: Rheumatology Section, Saint Joseph Hospital, Denver, Colorado 80218.
authors.forename: R B
authors.initials: RB
authors.lastname: Gibbons
authors.forename: E
authors.initials: E
authors.lastname: Westerman
mesh_terms: D000368:Aged; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced*; D008181:Lupus Nephritis / Q000188:drug therapy*; D011241:Prednisone / Q000008:administration & dosage; D012307:Risk Factors
chemical_list: D003520:Cyclophosphamide; D011241:Prednisone