title: [The antineoplastic activity of testiphenon].
abstract: The paper describes the antitumor activity of a newly-developed hormonocytostatic drug testiphenon--a complex ether of 5 alpha-dihydrotestosterone and chlorphenacyl (17 beta-[n-di/2-chloroethyl/aminophenylacetate]-5 alpha-androstan-17 beta-ol-3-on). Its antitumor properties were studied in 15 models of transplantable solid tumors and systemic neoplasms of mice and rats such as sarcoma 298, sarcoma 37, sarcoma-180, Lewis lung epidermoid carcinoma, carcinoma of the forestomach-5, large bowel adenocarcinoma, Harding-Passey's melanoma, cervical cancer-5, mammary adenocarcinoma Ca-755, hemoblastosis La, plasmacytoma MOPC-406, Rauscher's erythroblastosis, Walker's carcinosarcoma 256, sarcoma 45, alveolar carcinoma of the mammary gland and DMBA-induced mammary tumors of mice. The spectrum of antitumor activity of testiphenon proved wider than those of its components or other estrogeno-cytostatic drugs--phenestrol and estracyt. The drug is specifically intended for selective action upon target tissues for androgens and tumors developing from the said tissues.
authors.forename: N D
authors.initials: ND
authors.lastname: Lagova
authors.forename: Z P
authors.initials: ZP
authors.lastname: Sof'ina
authors.forename: E N
authors.initials: EN
authors.lastname: Shkodinskaia
authors.forename: K N
authors.initials: KN
authors.lastname: Kurdiumova
authors.forename: I M
authors.initials: IM
authors.lastname: Valueva
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D013196:Dihydrotestosterone / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D004285:Dogs; D004338:Drug Combinations / Q000627:therapeutic use / Q000633:toxicity; D005260:Female; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009588:Nitrogen Mustard Compounds / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats
chemical_list: D000970:Antineoplastic Agents; D004338:Drug Combinations; D009588:Nitrogen Mustard Compounds; D013196:Dihydrotestosterone; C058002:testiphenon
vernacular_title: Protivoopukholevoe deĭstvie testifenona.