A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity.
Strain C-1027, an actinomycete isolated from a soil sample collected in China, was found to produce the new antibiotic, C-1027. From taxonomical studies on its morphological, cultural and physiological characteristics, this antibiotic-producing strain was identified as Streptomyces globisporus C-1027. Antibiotic C-1027 has antimicrobial activity against most Gram-positive bacteria but not against Mycobacterium sp. or Gram-negative bacteria. This antibiotic shows remarkable activity in spermatogonial assay and potent cytotoxicity against KB carcinoma cells in vitro, and exhibits inhibition on transplantable tumors in mice.
Hu
J L
JL
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Xue
Y C
YC
Xie
M Y
MY
Zhang
R
R
Otani
T
T
Minami
Y
Y
Yamada
Y
Y
Marunaka
T
T
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D053281:Enediynes; D005285:Fermentation; D051379:Mice; D008826:Microbial Sensitivity Tests; D011506:Proteins / Q000302:isolation & purification; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D053281:Enediynes; D011506:Proteins; C058024:C 1027