title: [Comparison of the pharmacokinetics of iron in pregnant and nonpregnant women after oral administration of Vitaferro].
abstract: In this paper we represent results concerning pharmacokinetics and bioavailability of iron after the oral application of Vitaferro to women in the second half of pregnancy suffering or not from anaemia in comparison to nonpregnant women. The significance of different parameters used to proof an iron deficiency is discussed. In all pregnant probands the bioavailability of Vitaferro is about twice as high as in nonpregnant women. Also the parameters of elimination refer to an enhanced retention of iron during pregnancy. We conclude from our investigations that an iron deficiency may be diagnosed well by the determination of haemoglobin values, iron concentration in serum, binding capacity and resorption of iron. During pregnancy the preparation Vitaferro is well resorbed and does not cause incompatibilities. Thus it is suitable for the treatment of anaemia during pregnancy.
authors.affiliation: Klinik für Frauenheilkunde und Geburtsthilfe, Bereiches Medizin der Friedrich-Schiller-Universität Jena.
authors.forename: G
authors.initials: G
authors.lastname: Peiker
authors.forename: B
authors.initials: B
authors.lastname: Müller
authors.forename: H
authors.initials: H
authors.lastname: Dawczynski
authors.forename: M
authors.initials: M
authors.lastname: Erdmann
authors.forename: U
authors.initials: U
authors.lastname: Scharke
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000740:Anemia / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D006801:Humans; D007501:Iron / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy / Q000378:metabolism; D014815:Vitamins / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D014815:Vitamins; D007501:Iron
vernacular_title: Vergleichende Untersuchungen zur Pharmakokinetik von Eisen bei schwangeren und nichtschwangeren Frauen nach Gabe von Vitaferro.