The effect of starch malabsorption on fecal short-chain fatty acid excretion in man.
To study the impact of starch malabsorption on fecal short-chain fatty acid concentrations, 11 healthy volunteers consumed a controlled diet rich in starch for 2 4-week periods. They received the glucosidase inhibitor acarbose (Bay g 5421) in one of the study periods and placebo in the other. Stool wet weight increased by 68% and stool dry weight by 57% with acarbose. The fecal concentration (mumol/g wet weight) of n-butyrate (+58%) rose significantly when acarbose was added to the diet. The fecal excretion (mmol/day) of total short-chain fatty acids (+95%) and of their constituents acetate (+97%) and n-butyrate (+182%) was significantly higher when starch malabsorption was induced by acarbose.
Scheppach
W
W
Dept. of Medicine, Würzburg University, FRG.
Fabian
C
C
Sachs
M
M
Kasper
H
H
D000328:Adult; D001944:Breath Tests; D005232:Fatty Acids, Volatile / Q000032:analysis*; D005243:Feces / Q000032:analysis*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008286:Malabsorption Syndromes / Q000378:metabolism*; D008297:Male; D013213:Starch / Q000008:administration & dosage / Q000378:metabolism*
D005232:Fatty Acids, Volatile; D013213:Starch