[Anti-arrhythmic and vasodilator actions of the antioxidant fenozan in acute ischemia and reperfusion].
At the experiments with the isolated rat hearts, prepared by Langendorff, the anti-arrhythmic dose-effects of the water-soluble antioxidant fenozan from the class of steric-hindrance phenols were studied at condition of regional ischemia and reperfusion, as well as its action on the coronary flow. 3.6.10(-4) M of fenozan completely inhibited ischemic tachycardias, and diminished their incidence during reperfusion to 27%. The action of the fenozan in the concentration one order less, diminished total amount of reperfusion fibrillation to 67% (compared to 100% in control), the incidence of the long fibrillation to 67%, and considerably shifted their beginning to the moment of reperfusion. Dose-effects of anti-arrhythmic action of the antioxidant was V-shaped. Introduction of fenozan before 10 minutes of the occlusion caused an 1.5-2 hold increase of the coronary flow. This data show an effective antiarrhythmic and vasodilator action of the water-soluble phenol antioxidants during acute ischemia and reperfusion of myocardium.
Vasilets
L A
LA
Mokh
V P
VP
Plekhanova
L G
LG
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D003331:Coronary Vessels / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D008297:Male; D010666:Phenylpropionates / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D000975:Antioxidants; D010666:Phenylpropionates; D014665:Vasodilator Agents; C047854:fenozan
Antiaritmicheskoe i vazodilatornoe deĭstvie antioksidanta fenozana pri ostroĭ ishemii i referfuzii.