title: The pharmacokinetics of cefixime in the fasted and fed state.
abstract: Twenty healthy adult volunteers received single 400 mg oral doses of cefixime in an open, randomized, crossover study, administered twice in the fasted state and twice with a standard breakfast. The study design allowed both an evaluation of a potential food effect and also an analysis of both intrasubject and intersubject variability in the fasted and fed state. There was a small but significantly longer (approximately 1 h) time to peak concentration when the drug was given with food. Peak serum concentrations, area under the curve, and 24 h urinary recovery values were unchanged in the fed and fasted states. The terminal elimination half-life of the drug given after a meal (3.6 h) was slightly longer than that observed after dosing in the fasting condition (3.5 h). The intrasubject and intersubject variabilities were less than 12% and 33% respectively, for both area under the curve and 24 h urinary recovery, and were virtually the same for the fasted and fed occasions. Therefore, the drug may be administered with or without food.
authors.affiliation: Medical Research Division, American Cyanamid Company, Pearl River, New York.
authors.forename: R D
authors.initials: RD
authors.lastname: Faulkner
authors.forename: W
authors.initials: W
authors.lastname: Bohaychuk
authors.forename: J D
authors.initials: JD
authors.lastname: Haynes
authors.forename: R E
authors.initials: RE
authors.lastname: Desjardins
authors.forename: A
authors.initials: A
authors.lastname: Yacobi
authors.forename: B M
authors.initials: BM
authors.lastname: Silber
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D020682:Cefixime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D005215:Fasting; D005502:Food; D006801:Humans; D008297:Male
chemical_list: D020682:Cefixime; D002439:Cefotaxime