Liver injury due to verapamil.
A 56-year-old female patient on verapamil for hypertension experienced two episodes of jaundice, pruritus and upper abdominal pain with transaminase elevated up to six-fold and alkaline phosphatase up to four-fold when inadvertently re-challenged with the drug. Liver biopsy showed marked cholestasis. Verapamil can occasionally cause mixed cytotoxic-cholestatic liver injury.
Burgunder
J M
JM
Department of Clinical Pharmacology, University of Berne, CH-Switzerland.
Abernethy
D R
DR
Lauterburg
B H
BH
D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008875:Middle Aged; D014700:Verapamil / Q000009:adverse effects* / Q000627:therapeutic use
D014700:Verapamil