title: Adaptation of electrolytes and fluid transport in rat small and large intestine after distal small bowel resection.
abstract: Na+, Cl- and water transport were studied in jejunum, caecum and colon after either 50% or 80% of small bowel resection (SBR). Four weeks after surgery, dry and wet weights, net absorption in vivo of sodium, chloride and water were determined. There was a significant intestinal growth after 50% or 80% SBR except for the colon which only showed increased tissue mass after 80% SBR. Net transport was stimulated both, per organ and per unit mass. In the small intestine and caecum both organ growth and changes in cell function appear to be involved in the adaptive response, regardless the extent of the small intestine resected. In the colon, compensatory growth appear to contribute to the adaptive response only after 80% SBR, whilst the transport function of the colonocytes seems to be stimulated after both types of SBR.
authors.affiliation: Departamento Fisiología Animal, Facultad de Farmacia, Universidad de Sevilla, Spain.
authors.forename: C M
authors.initials: CM
authors.lastname: Vázquez
authors.forename: M T
authors.initials: MT
authors.lastname: Molina
authors.forename: A
authors.initials: A
authors.lastname: Ilundain
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001692:Biological Transport; D002432:Cecum / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism*; D003106:Colon / Q000378:metabolism; D007420:Intestine, Large / Q000378:metabolism* / Q000502:physiology; D007421:Intestine, Small / Q000601:surgery*; D007583:Jejunum / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*; D014867:Water / Q000378:metabolism*
chemical_list: D002712:Chlorides; D014867:Water; D012964:Sodium