Oxygen-17 contrast agents. Fast imaging techniques.
Under physiologic conditions the stable isotope oxygen-17, in the form of O-17 water, lowers the proton T2 of blood, CSF, tissues, and whole organisms. With MRI the resulting changes in intensity can be detected using spin-echo pulse sequences, but much greater sensitivity is achieved in a fraction of the time with a steady-state free precession sequence such as FISP. With this sequence it is possible to detect levels as low as 0.4% Oxygen-17 water in 53 seconds or less.
Hopkins
A L
AL
Case Western Reserve University, Department of Anatomy, Cleveland, OH 44106.
Haacke
E M
EM
Barr
R G
RG
Tkach
J
J
D003287:Contrast Media; D006801:Humans; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging; D010103:Oxygen Isotopes; D013997:Time Factors
D003287:Contrast Media; D010103:Oxygen Isotopes