[Treatment of experimental trypanosomiasis of sheep caused by Trypanosoma brucei brucei: efficacy of Ro 15-0216 (a 2-nitroimidazole derivative)].
An experiment was carried out on treatment of Trypanosoma brucei brucei experimentally infected sheep with central nervous system involvement with a 2-nitroimidazole derivative: Ro 15-0216 (Hoffmann La Roche & Co Ltd, Basel, Switzerland). After a single intramuscularly or intravenously administration (25 or 50 mg/kg) of this compound in healthy sheep, levels of more than 1 microgram/ml corresponding to trypanocidal concentrations are detected in both blood and cerebrospinal fluid. However, because of short half life, two or three injections a day appeared to be necessary. Six infected sheep were treated by daily intravenous injection for six days: three animals with 25 mg/kg/d and three others with 50 mg/kg/d. Animals which relapsed received 50 mg/kg/d divided in three intravenous injections a day for six days. After a year of observation, all the animals were considered clinically and biologically cured.
Bouteille
B
B
Service de Parasitologie-Mycologie, C.H.U. Dupuytren, Limoges.
Darde
M L
ML
Pestre-Alexandre
M
M
Dumas
M
M
Breton
J C
JC
Nicolas
J A
JA
Catanzano
G
G
Munoz
M
M
D000083:Acetanilides / Q000627:therapeutic use*; D000818:Animals; D009593:Nitroimidazoles / Q000627:therapeutic use*; D012756:Sheep; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014346:Trypanosoma brucei brucei; D014353:Trypanosomiasis, African / Q000188:drug therapy*
D000083:Acetanilides; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C054646:Ro 15-0216
Traitement de la trypanosomiase expérimentale du mouton à Trypanosoma brucei brucei: efficacité du Ro 15-0216 (dérivé 2-nitroimidazolé).