Effect of long-term administration of 1,2,3,4-tetrahydroisoquinoline (TIQ) on striatal dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) content in mice.
Effects of long-term administration of 1,2,3,4-tetrahydroisoquinoline (TIQ) on the striatal dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) were investigated in mice and rats. Striatal dopamine content significantly increased and DOPAC decreased after repeated administrations of TIQ at a dose of 50 mg/kg/day s.c. for 70 days in mice. In contrast, dopamine and DOPAC content did not show any significant change in rats. The ratio DOPAC/dopamine decreased significantly in mice treated with TIQ for 70 days. The results presented suggest that TIQ reduces the turnover rate of the nigrostriatal dopamine neurons after repeated administration for a long period in mice.
Saitoh
T
T
Department of Neurology, Jichi Medical School, Tochigi, Japan.
Mizuno
Y
Y
Nagatsu
T
T
Yoshida
M
M
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism*; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D007546:Isoquinolines / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010648:Phenylacetates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D044005:Tetrahydroisoquinolines; D013997:Time Factors
D007546:Isoquinolines; D010648:Phenylacetates; D044005:Tetrahydroisoquinolines; D015102:3,4-Dihydroxyphenylacetic Acid; C014843:1,2,3,4-tetrahydroisoquinoline; D004298:Dopamine