title: Phencyclidine reduces postischemic neuronal necrosis in rat hippocampus without changing blood flow.
abstract: In this report the effects of phencyclidine (PCP) on physiologic variables, local cerebral blood flow (LCBF), and on hippocampal cell damage were measured in a rat model of forebrain ischemia (2-vessel occlusion and hypotension). Ischemia was induced for 10 min. LCBF was determined after 2 min of recirculation, using the [14C]iodoantipyrine technique. Hippocampal cell loss was quantified histologically 7 days postischemia as the percentage of acidic stainable neurons. Intravenous application of PCP (2 mg/kg) at 15 min prior to ischemia left postischemic LCBF unchanged, but neuronal damage was significantly reduced in hippocampal CA1 sector from 46 to 15.7%. PCP is concluded to reduce ischemic damage of neurons mainly via a direct effect on brain tissue.
authors.affiliation: Institut für Pharmakologie und Toxikologie, Philipps-Universität, Marburg, F.R.G.
authors.forename: D
authors.initials: D
authors.lastname: Sauer
authors.forename: J
authors.initials: J
authors.lastname: Nuglisch
authors.forename: C
authors.initials: C
authors.lastname: Rossberg
authors.forename: H D
authors.initials: HD
authors.lastname: Mennel
authors.forename: T
authors.initials: T
authors.lastname: Beck
authors.forename: G W
authors.initials: GW
authors.lastname: Bielenberg
authors.forename: J
authors.initials: J
authors.lastname: Krieglstein
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009336:Necrosis; D010622:Phencyclidine / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010622:Phencyclidine