Pharmacokinetics of centperazine: a new antifilarial agent.
Blood concentration compared with time profile of centperazine, obtained after intravenous injection of a 5 mg/kg dose in male albino rats, was analysed for various parameters. The data could be interpreted best in terms of the three compartment open model system. The drug exhibited 4.4 h of half-life, with an elimination constant of 1.65. Values for the area under curve and distribution volume were determined as 14.62 micrograms h/ml and 438 ml respectively. Only 10% of centperazine present in the central compartment was available for elimination at any one time. Mean plasma clearance value was found to be 72.87 ml/h/kg body weight.
Agarwal
N
N
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Sharma
S
S
Srivastava
V M
VM
D000818:Animals; D000871:Anthelmintics / Q000493:pharmacokinetics*; D005369:Filaricides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D010879:Piperazines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000871:Anthelmintics; D005369:Filaricides; D010879:Piperazines; C033224:centperazine