title: Working capacity is increased following recombinant human erythropoietin treatment.
abstract: To investigate the effect of partial correction of anemia in patients maintained by chronic intermittent hemodialysis on aerobic and anaerobic working capacity, eight patients underwent a bicycle spiro-ergometry before and after treatment with recombinant human erythropoietin (r-HuEPO). the initial mean (+/- SD) hemoglobin value was 5.9 mg/dl +/- 0.61 and increased during treatment to 10.9 +/- 0.59 mg/dl, P less than 0.0001). This partial correction of anemia resulted in a significant increase of both oxygen uptake at the anaerobic threshold and peak peripheral oxygen uptake at subjective exhaustion (P less than 0.01 and P less than 0.0002, respectively). The increase in oxygen uptake corresponded to significant increases in Watts, both at the anaerobic threshold and at maximum workload (P less than 0.02 and P less than 0.0004). These data show that partial correction of renal anemia results in a significant increase of both exercise capacity and maximum work.
authors.affiliation: 2nd Department of Medicine, University of Vienna, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Mayer
authors.forename: J
authors.initials: J
authors.lastname: Thum
authors.forename: E M
authors.initials: EM
authors.lastname: Cada
authors.forename: H K
authors.initials: HK
authors.lastname: Stummvoll
authors.forename: H
authors.initials: H
authors.lastname: Graf
mesh_terms: D000328:Adult; D000693:Anaerobiosis; D000740:Anemia / Q000503:physiopathology / Q000628:therapy*; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D005082:Physical Exertion; D011994:Recombinant Proteins / Q000627:therapeutic use; D006435:Renal Dialysis
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin