Trans-3'-hydroxycotinine--a main metabolite in smokers.
Trans-3'-hydroxycotinine was found to be a main metabolite of nicotine in smokers. It is the most abundant among all nicotine metabolites, if the total urine is collected over 7 consecutive days of smoking and 5 following days without smoking. Its steady-state blood plasma concentration on the 6th day of smoking is second only to cotinine. In the experiments nine habitual smokers smoked 19 cigarettes per day on 7 days of smoking. Three runs were carried out with three types of cigarettes which differed in mainstream nicotine. After oral administration of 30 mg trans-3'-hydroxycotinine, the cumulative excretion rates of two subjects were 81% and 93% of the unchanged compound, respectively.
Neurath
G B
GB
Institut für Biopharmazeutische Mikroanalytik, Hamburg.
Dünger
M
M
Krenz
O
O
Orth
D
D
Pein
F G
FG
D000328:Adult; D001711:Biotransformation; D003367:Cotinine / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000493:pharmacokinetics; D011760:Pyrrolidinones / Q000493:pharmacokinetics*; D012907:Smoking / Q000652:urine*; D013237:Stereoisomerism
D011760:Pyrrolidinones; C001381:hydroxycotinine; D009538:Nicotine; D003367:Cotinine