Regional assignment of the gene coding for human sucrase-isomaltase (SI) to chromosome 3q25-26.
The gene coding for sucrase-isomaltase (SI) has recently been mapped to chromosome 3 using a cDNA probe to analyse DNA from somatic cell hybrids (Green et al. 1987). We have now used this same cDNA probe to obtain a regional localization of this gene. In situ hybridization to normal metaphase chromosomes and to chromosomes from individuals with balanced translocations suggests a regional assignment to chromosome 3q25-26.
West
L F
LF
MRC Human Biochemical Genetics, Galton Laboratory, University College London.
Davis
M B
MB
Green
F R
FR
Lindenbaum
R H
RH
Swallow
D M
DM
D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D004247:DNA; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D009097:Multienzyme Complexes / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D013394:Sucrase-Isomaltase Complex / Q000235:genetics*
D009097:Multienzyme Complexes; D004247:DNA; D013394:Sucrase-Isomaltase Complex