title: Ofloxacin compared with ciprofloxacin in the treatment of complicated lower urinary tract infections.
abstract: In a double-blind, double-dummy study 61 patients with structural or functional abnormalities of the urinary tract and verified infection were treated for 7 days with ofloxacin 100 mg bd or ciprofloxacin 250 mg bd by mouth. Of 62 isolated strains none was resistant to ofloxacin or ciprofloxacin in vitro. Nineteen patients (63%) in both groups were free from infection ten days after therapy. Clinical resolution of symptoms occurred in 83% in the ofloxacin group and 68% in the ciprofloxacin group. Adverse reactions were reported in four patients (6.5%), two with skin rash, one with gastrointestinal disturbance and one with influenza-like symptoms. This study demonstrates that ofloxacin and ciprofloxacin are effective in the treatment of complicated lower urinary tract infection.
authors.affiliation: Department of Urology, Herlev Hospital, University of Copenhagen, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Kromann-Andersen
authors.forename: P
authors.initials: P
authors.lastname: Sommer
authors.forename: C
authors.initials: C
authors.lastname: Pers
authors.forename: V
authors.initials: V
authors.lastname: Larsen
authors.forename: F
authors.initials: F
authors.lastname: Rasmussen
mesh_terms: D002939:Ciprofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D015242:Ofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy*
chemical_list: D002939:Ciprofloxacin; D015242:Ofloxacin