The effect of fish oil on lipids, coagulation and fibrinolysis in patients with angina pectoris.
The effect of fish oil on lipids, coagulation and fibrinolysis was investigated in patients with stable angina pectoris. The patients were given a daily supplement of 4.5 g n-6 polyunsaturated fatty acids (PUFA's) for 4 weeks and were then randomized to the same oil or to fish oil (4.5 g n-3 PUFA's) for 12 weeks. Blood samples were taken before and after 16 weeks of oil supplementation. Lipids, coagulation and fibrinolysis were measured in 14 patients treated with fish oil. There was a significant decrease in triglycerides and very low density lipoproteins but unexpectedly a significant increase in total cholesterol from 5.9 to 6.7 mmol/l after fish oil. The fibrinolytic activity at rest determined by the fibrin plate method showed a decrease after fish oil. Other measurements did not reveal any statistically significant changes. These finding necessitate caution with uncontrolled supplementation with fish oil in patients with stable angina pectoris.
Schmidt
E B
EB
Department of Clinical Chemistry, Aalborg Hospital, Denmark.
Kristensen
S D
SD
Dyerberg
J
J
D000787:Angina Pectoris / Q000097:blood / Q000178:diet therapy*; D001777:Blood Coagulation; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use*; D004281:Docosahexaenoic Acids; D004338:Drug Combinations; D015118:Eicosapentaenoic Acid; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation
D004042:Dietary Fats, Unsaturated; D004338:Drug Combinations; D005231:Fatty Acids, Unsaturated; D008055:Lipids; C045153:Maxepa; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid