Reproducibility of heart rate changes following adenosine infusion in man.
The change in heart rate following infusion of adenosine in healthy human subjects was studied on two occasions. Adenosine produced a significant, dose-related increase in heart rate. Tachyphylaxis to this effect of the naturally occurring nucleoside did not occur. There was a tendency for prolonged infusion to cause a greater increase in heart rate, but this did not reach significance.
Clarke
B
B
Department of Clinical Pharmacology, Cardiothoracic Institute, Brompton Hospital, London, UK.
Conradson
T B
TB
Dixon
C M
CM
Barnes
P J
PJ
D000241:Adenosine / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D013618:Tachyphylaxis
D000241:Adenosine