The activation peptide of pancreatic procolipase decreases food intake in rats.
Pancreatic procolipase is a cofactor for lipase and necessary for optimal fat digestion in the intestine during a meal. It is activated by trypsin in the intestine during release of an activation peptide, with the sequence Val-Pro-Asp-Pro-Arg in rat. This peptide, in the following termed VPDPR, was found to decrease food intake in rats. The human procolipase activation peptide with the sequence Ala-Pro-Gly-Pro-Arg (APGPR) had no effect on food intake in rats, nor the trypsinogen activation peptide with the sequence Phe-Pro-Val-Asp-Asp-Asp-Asp-Lys (FPVDDDDK). Procolipase added to standard pellets decreased the daily food intake in rats, whereas colipase added to pellets had no effect.
Erlanson-Albertsson
C
C
Department of Medical and Physiological Chemistry, University of Lund, Sweden.
Larsson
A
A
D000818:Animals; D003089:Colipases / Q000032:analysis / Q000502:physiology*; D004435:Eating / Q000187:drug effects*; D004789:Enzyme Activation; D004792:Enzyme Precursors; D005260:Female; D010179:Pancreas / Q000201:enzymology*; D010446:Peptide Fragments / Q000494:pharmacology*; D011498:Protein Precursors / Q000032:analysis / Q000502:physiology*; D011506:Proteins / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D003089:Colipases; D004792:Enzyme Precursors; D010446:Peptide Fragments; D011498:Protein Precursors; D011506:Proteins; C037107:procolipase