[Selective analgetic effects of angiotensin and bombesin during the action of dental and cutaneous nociceptive irritants].
In non-anesthesized rabbits intraventricular injection of angiotensin II reduced the amplitude of somatosensory evoked potential to nociceptive tooth pulp, but not to nociceptive electrocutaneous stimulation. The same injection of bombesin induced the contrary analgetic effect. The systemic naloxone (0.1 mg/kg) injection didn't reverse the peptides analgetic effects. It's suggested that selective analgetic effects of angiotensin II and bombesin are determined by the presence of the specific different peptide mechanisms for nociception with the different pain genesis.
Raevskaia
O S
OS
Fedoseeva
O V
OV
Kaliuzhnyĭ
L V
LV
D000700:Analgesics / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D003782:Dental Pulp; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D011817:Rabbits; D012867:Skin
D000700:Analgesics; D000804:Angiotensin II; D009270:Naloxone; D001839:Bombesin
Izbiratel'nost' analgeziruiushchikh éffektov angiotenzina i bombezinapri deĭstvii dental'nykh i kozhnykh notsitseptivnykh razdrazhiteleĭ.