Enzyme abnormalities of patients with acquired immunodeficiency syndrome.
We determined the enzyme activities of glucose-6-phosphate isomerase, alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase in serum from 23 normal controls, 27 anti-HIV seropositive individuals confirmed by Western blot, and 53 patients with acquired immunodeficiency syndrome (AIDS). There is a significant difference for all four enzyme activities among controls, HIV seropositive individuals, and patients with AIDS, the enzyme activities showing a progressive increase as the disease progresses. Evidently these enzyme measurements may be adjunctive biochemical markers for progression of AIDS.
Huang
C M
CM
Clinical Pathology Department, Warren Grant Magnuson Clinical Center, Bethesda, MD 20892.
Ruddel
M
M
Elin
R J
RJ
D000163:Acquired Immunodeficiency Syndrome / Q000201:enzymology*; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D015153:Blotting, Western; D005956:Glucose-6-Phosphate Isomerase / Q000097:blood; D006679:HIV Seropositivity; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005956:Glucose-6-Phosphate Isomerase