The anti-ulcer effect in rats of ginger constituents.
The effects of ginger, a pungent stomachic natural medicine, on HCl/ethanol-induced gastric lesions in rats, were examined. The orally administered acetone extract at 1000 mg/kg and zingiberene, the main terpenoid from acetone extract, at 100 mg/kg significantly inhibited gastric lesions by 97.5 and 53.6%, respectively. 6-Gingerol, the pungent principle, at 100 mg/kg significantly inhibited gastric lesions by 54.5%. These results suggest that zingiberene, the terpenoid and 6-gingerol are important constituents in stomachic medications containing ginger.
Yamahara
J
J
Kyoto Pharmaceutical University, Japan.
Mochizuki
M
M
Rong
H Q
HQ
Matsuda
H
H
Fujimura
H
H
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002396:Catechols; D002599:Chalcone / Q000031:analogs & derivatives / Q000627:therapeutic use; D047188:Chalcones; D004224:Diterpenes / Q000627:therapeutic use; D005233:Fatty Alcohols / Q000627:therapeutic use; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000473:pathology
D000897:Anti-Ulcer Agents; D002396:Catechols; D047188:Chalcones; D004224:Diterpenes; D005233:Fatty Alcohols; D010936:Plant Extracts; C035032:sofalcone; D002599:Chalcone; C007845:gingerol; C031049:geranylgeranylacetone