title: Maximal binding levels of an H1 histone gene-specific factor in S-phase correlate with maximal H1 gene transcription.
abstract: Levels of trans-acting factor (H1-SF) binding to the histone H1 gene-specific motif (5'-AAACACA-3' [L. S. Coles and J. R. E. Wells, Nucleic Acids Res. 13:585-594, 1985]) increase 12-fold from G1 to S-phase in synchronized cells and decrease again in G2 phase of the cell cycle. Since the H1 element is required for S-phase expression of H1 genes (S. Dalton and J. R. E. Wells, EMBO J. 7:49-56, 1988), it is likely that the increased levels of H1-SF binding component play an important role in S-phase regulation of H1 gene transcription.
authors.affiliation: Department of Biochemistry, University of Adelaide, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Dalton
authors.forename: J R
authors.initials: JR
authors.lastname: Wells
mesh_terms: D000818:Animals; D001483:Base Sequence; D002467:Cell Nucleus / Q000378:metabolism; D002645:Chickens; D004268:DNA-Binding Proteins / Q000502:physiology*; D005786:Gene Expression Regulation; D006657:Histones / Q000235:genetics*; D007399:Interphase; D009687:Nuclear Proteins / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D006657:Histones; D009687:Nuclear Proteins; D014157:Transcription Factors