Persistence of antibody titres three years after vaccination with Vi polysaccharide vaccine against typhoid fever.
After a single injection of purified Vi polysaccharide vaccine against typhoid fever, serum titres were followed in student volunteers by passive haemagglutination assay and by radioimmunoassay. Elevated Vi antibody titres were still present after 36 months. This preliminary study should be followed by further investigations on the extent and duration of protection provided by Vi vaccine, and on volunteers in endemic areas.
Tacket
C O
CO
Department of Medicine, University of Maryland, Baltimore 21201.
Levine
M M
MM
Robbins
J B
JB
D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D000942:Antigens, Bacterial / Q000276:immunology*; D006386:Hemagglutination Tests; D006801:Humans; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D011863:Radioimmunoassay; D012485:Salmonella typhi / Q000276:immunology*; D013997:Time Factors; D014435:Typhoid Fever / Q000517:prevention & control; D014436:Typhoid-Paratyphoid Vaccines / Q000276:immunology*; D014611:Vaccination
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D011135:Polysaccharides, Bacterial; D014436:Typhoid-Paratyphoid Vaccines; C057664:Vi polysaccharide vaccine, typhoid