title: Respiratory morbidity in workers exposed to asbestos in the primary manufacture of building materials.
abstract: Former employees (214) of a plant that manufactured asbestos-containing building materials (wallboard and acoustic tile) from 1958 through 1974 were screened for asbestos-related pulmonary disease. Results are presented on 182 union members whose names appeared on a 1966 seniority list in one of six departments believed to have had substantial asbestos exposure. The study population demonstrated a high frequency of pulmonary abnormalities often associated with asbestos exposure: low mean forced vital capacity percent of predicted (FVC % predicted), low mean forced expiratory volume at one second percent of predicted (FEV1 % predicted), presence of parenchymal abnormalities (40.1% with profusion scores of 1/0 or higher), and 30.5% with bilateral pleural abnormalities on chest roentgenograms. In addition, râles in two or more locations were found in 22.8% on examination of the chest, 30.6% gave a history of chronic bronchitis, and 34.8% of dyspnea grade two or higher. Calculated asbestos exposure scores, based upon participant recall, were not found to be associated with these abnormalities. The abnormal findings were not adequately explained by potential confounders such as cigarette smoking. Other notable findings in this study include the presence of smoking-adjusted decrements in pulmonary function associated with moderate profusion scores (i.e., 1/0 and 1/1) and the presence of a substantial degree of obstructive lung disease (19.2%) in this population.
authors.affiliation: Department of Environmental and Industrial Health, School of Public Health, University of Michigan, Ann Arbor 48109-2029.
authors.forename: T G
authors.initials: TG
authors.lastname: Robins
authors.forename: M A
authors.initials: MA
authors.lastname: Green
mesh_terms: D000328:Adult; D000368:Aged; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D001194:Asbestos / Q000009:adverse effects*; D003252:Construction Materials; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000503:physiopathology; D010995:Pleural Diseases / Q000139:chemically induced* / Q000503:physiopathology; D012129:Respiratory Function Tests; D012907:Smoking / Q000009:adverse effects
chemical_list: D000395:Air Pollutants, Occupational; D001194:Asbestos