[Synaptic function of the cerebral cortex in gamma irradiation].
In adult rats 1.6 to 4.3 hrs after a single dose of gamma-irradiation (200 Gy), with developing neurological disorders, destructive changes were found in most of the synapses of brain sensorimotor cortex. All functionally important parts on the axonal and dendritic sides of the synapses were altered: mitochondria, synaptic vesicles, pre- and postsynaptic membranes, synaptic complexes and subsynaptic consolidations axonal and dendritic plasma and their incorporations. These changes are possibly causing the neurons disconnection and provide a structural basis for neurological deficits after substantial ionizing irradiation.
Gaĭdamakin
N A
NA
Ushakov
I B
IB
D000818:Animals; D001927:Brain Diseases / Q000209:etiology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology / Q000528:radiation effects*; D005720:Gamma Rays; D008297:Male; D008854:Microscopy, Electron; D011833:Radiation Injuries, Experimental / Q000150:complications / Q000503:physiopathology; D051381:Rats; D013569:Synapses / Q000502:physiology / Q000528:radiation effects* / Q000648:ultrastructure; D013997:Time Factors
Sostoianie sinapsov kory bol'shikh polushariĭ golovnogo mozga pri gamma-obluchenii.