Induction of micronuclei in Vicia faba root tips treated with heavy metals (cadmium and chromium) in the presence of NTA.
Soluble metal compounds (CdCl2, K2Cr2O7) significantly increase the frequency of micronucleated cells in Vicia faba root tips with a clear dose-effect relationship. The addition of NTA (nitrilotriacetic acid) does not enhance the induction of micronucleated cells. Conversely, insoluble metal compounds (CdCO3, PbCRO4) significantly enhance the frequency of micronucleated cells only in the presence of NTA. Since some genotoxic metals are diffused in the environment and are often sequestered as insoluble precipitates in water sediments and sludges, the introduction of NTA is likely to increase the risk of environmental pollution because of its ability to solubilize and make those metals reactive.
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Centro di Genetica Evoluzionistica C.N.R., Università La Sapienza, Roma, Italy.
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D000085:Acetates / Q000633:toxicity*; D002104:Cadmium / Q000633:toxicity*; D002857:Chromium / Q000633:toxicity*; D002869:Chromosome Aberrations; D004357:Drug Synergism; D015162:Micronucleus Tests / Q000379:methods*; D009154:Mutation / Q000187:drug effects*; D009571:Nitrilotriacetic Acid / Q000633:toxicity*; D010944:Plants; D012995:Solubility
D000085:Acetates; D002104:Cadmium; D002857:Chromium; D009571:Nitrilotriacetic Acid