Protein C in acute renal failure.
In 16 patients with acute renal failure we studied protein C activity, both coagulant and amidolytic, as well as protein C antigen level. Protein C coagulant activity was markedly decreased in acute renal failure. Furthermore, changes in kidney function were paralleled by alterations in protein C coagulant activity. The amidolytic activity and antigen level of protein C were normal in most cases, and the changes observed in a few patients seem clearly related to changes in liver function. This defective protein C could contribute to the thrombotic tendency reported in patients with acute renal failure.
Sørensen
P J
PJ
Department of Nephrology, Aalborg Hospital, Denmark.
Knudsen
F
F
Nielsen
A H
AH
Dyerberg
J
J
D058186:Acute Kidney Injury / Q000097:blood*; D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000032:analysis*
D011486:Protein C; D003404:Creatinine