Phagocytic system stimulation in experimental atherosclerosis of chicks.
The effects of activation of the phagocytic system by BCG on the development of diet-induced atherosclerosis was studied in chicken. Injections of BCG had a marked effect on atherogenesis, which was either inhibitory or stimulatory, depending on the route of BCG administration and on the timing. A slight, but significant inhibition was obtained by intraperitoneal injection of BCG administered during the dietary treatment. A more pronounced and significant inhibition was observed in chicks given BCG subcutaneously 8 weeks before the start of the dietary regimen. The findings are consistent with a previously proposed notion that immunization at an early age may affect the course of later life atherosclerosis.
Gaton
E
E
Department of Pathology, Tel-Aviv University Sackler Faculty of Medicine, Israel.
Orgad
U
U
Weisman
Y
Y
Wolman
M
M
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology*; D001500:BCG Vaccine / Q000008:administration & dosage / Q000494:pharmacology; D002645:Chickens; D004036:Diet, Atherogenic; D010586:Phagocytes / Q000502:physiology*; D013997:Time Factors
D001500:BCG Vaccine