Transient blindness and seizure associated with cisplatin therapy.
A 38-year-old woman with adenocarcinoma of unknown origin was treated with cisplatin and etoposide. After the 4th course of chemotherapy she complained of blindness and had a seizure with spontaneous recovery in 4 days. The relationship between these events and the known neurotoxicity of other heavy metals indicate cisplatin as a possible etiologic factor.
Cattaneo
M T
MT
Clinica Medica Generale, Università di Milano, Italy.
Filipazzi
V
V
Piazza
E
E
Damiani
E
E
Mancarella
G
G
D000230:Adenocarcinoma / Q000188:drug therapy; D000328:Adult; D001766:Blindness / Q000139:chemically induced*; D002945:Cisplatin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D012640:Seizures / Q000139:chemically induced*
D002945:Cisplatin