Hearing loss and desferrioxamine in homozygous beta-thalassemia.
The authors present the results obtained during an audiometric screening of 153 children aged 5-18 years, affected by beta-thalassemia and treated with regular blood transfusions and iron overload chelation by means of desferrioxamine. Thirty-eight percent of the patients showed a significant sensorineural hearing loss at high frequencies with recruitment. Younger patients had a greater hearing loss, indicating that cochlear damage was not due to the disease itself. Furthermore, hearing loss appeared to be correlated with the mean and peak desferrioxamine doses administered and was higher in subjects with lower iron load. Thus, the ototoxic effect seems to have been higher when a good iron chelation had been obtained. Among our patients, conductive hearing loss was not more frequent than in patients without beta thalassemia.
Albera
R
R
ENT Department, University of Turin, Italy.
Pia
F
F
Morra
B
B
Lacilla
M
M
Bianco
L
L
Gabutti
V
V
Piga
A
A
D000293:Adolescent; D001299:Audiometry; D002648:Child; D003676:Deferoxamine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006314:Hearing Loss, Conductive / Q000209:etiology; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D008297:Male; D013789:Thalassemia / Q000188:drug therapy*
D003676:Deferoxamine