The beneficial effect of ketoacids on serum phosphate and parathyroid hormone in patients with chronic uremia.
Hyperphosphatemia and secondary hyperparathyroidism are regular complications in patients suffering from advanced renal failure. As aluminum-containing drugs carry the well-known risk of aluminum intoxication, we were interested in testing in a prospective study a mixture of ketoanalogues and amino acids which have been shown to lower the serum phosphate and parathyroid hormone in uremic patients. For 3 months, in addition to their diet, 17 uremic patients and 12 hemodialysis patients received a daily supplement of this mixture. Although no additional phosphate binders were administered, serum phosphate decreased significantly in the former group and was slightly lower in the latter. The serum parathyroid hormone level was consistently lowered when the initial concentration was not higher than 20 times normal.
Schaefer
K
K
St. Joseph-Hospital I, Medical Division II, Berlin, FRG.
von Herrath
D
D
Asmus
G
G
Umlauf
E
E
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000601:Amino Acids, Essential / Q000008:administration & dosage / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007651:Keto Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000097:blood; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010710:Phosphates / Q000097:blood*; D011446:Prospective Studies; D006435:Renal Dialysis; D014443:Tyrosine / Q000008:administration & dosage / Q000627:therapeutic use*; D014508:Urea / Q000097:blood; D014511:Uremia / Q000097:blood* / Q000178:diet therapy
D000601:Amino Acids, Essential; D007651:Keto Acids; D010281:Parathyroid Hormone; D010710:Phosphates; D014443:Tyrosine; D014508:Urea; D003404:Creatinine