Neoplastic disease in a medicolegal autopsy material. A retrospective study in northern Sweden.
Only a small fraction of sudden unexpected deaths are caused by neoplastic disease and thus subject ot medicolegal autopsy. The medicolegal autopsy forms an opportunity to study not only medically diagnosed and treated neoplasms, but also the natural evolution of untreated disease. In a series of 7,020 consecutive medicolegal autopsies in northern Sweden, we found 171 cases with malignant and/or intracranial neoplasms. In 41 cases, sudden death was caused by previously unknown tumors. The most common mechanisms of death in this group were disseminated cancer, intracranial tumors, pulmonary thromboembolism, hemoptysis, and aspiration of blood, and the most common locations were the bronchi and the lung. In some of these cases, the mechanism was sometimes dramatic, raising a question of violent death or intoxication. In 30 cases, sudden unexpected death was caused by previously known tumors, and also in this group disseminated cancer was the most common cause of death, and the most common locations were the bronchi and the lung. In 22 cases, tumors were found suicidal cases; in 14 of these, the tumor was considered to be a major causative factor to the suicide, while in eight cases the tumor was considered to be an incidental finding. The expected number of cancers in the 1,060 suicides investigated in this series was 27, according to the official cancer prevalence data. Thus, a possible over-representation of suicides among persons with cancer seems doubtful and needs further exploration.
Gezelius
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Institute of Forensisc Medicine, University of Umeå, Sweden
Eriksson
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D000328:Adult; D000368:Aged; D001344:Autopsy; D002423:Cause of Death; D003645:Death, Sudden / Q000473:pathology*; D005260:Female; D006708:Homicide; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology*; D009382:Neoplasms, Unknown Primary / Q000473:pathology; D012189:Retrospective Studies; D013405:Suicide / Q000331:legislation & jurisprudence; D013548:Sweden; D014947:Wounds and Injuries / Q000473:pathology