Antimetastatic effect of bromelain with or without its proteolytic and anticoagulant activity.
Bromelain, a pineapple-derived plant product, added to C57Bl/6 mice laboratory chow decreased lung metastasis of Lewis lung cancer cells implanted s.c. This antimetastatic potential was demonstrated by both the active and inactive bromelain with or without proteolytic, anticoagulant properties.
Batkin
S
S
Cancer Research Center, University of Hawaii, Honolulu 96813.
Taussig
S J
SJ
Szekerezes
J
J
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D001963:Bromelains / Q000494:pharmacology / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis
D000925:Anticoagulants; D000972:Antineoplastic Agents, Phytogenic; D001963:Bromelains