[Action of khanerol on the superhelical DNA structure of S-37 cells].
The damaging effects on the structure of a supramolecular DNA complex of sarcoma-37 cells in mice following the use of the therapeutic doses of khanerol were found. Capillary elastoviscosimetry and nucleoid sedimentation procedure showed that the damage of the supramolecular DNA complex structure becomes apparent already after 4 hours, and increases by 24 hour. In studies of the binding of khanerol with DNA by Cd and Tmelt. the procedure showed direct interaction of khanerol with DNA. The role of conformational changes of the supramolecular DNA complex in the cytotoxic action of antitumour agents is discussed.
Struchkov
V A
VA
Suslova
O A
OA
Lobachev
V M
VM
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D002942:Circular Dichroism; D004273:DNA, Neoplasm / Q000187:drug effects*; D004278:DNA, Superhelical / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D010636:Phenols; D012511:Sarcoma 37 / Q000188:drug therapy* / Q000235:genetics; D012513:Sarcoma, Experimental / Q000188:drug therapy*; D013997:Time Factors; D014783:Viscosity
D000972:Antineoplastic Agents, Phytogenic; D004273:DNA, Neoplasm; D004278:DNA, Superhelical; D010636:Phenols; C057686:chanerol
Deĭstvie khanerola na superspiral'nuiu strukturu DNK kletok S-37.