title: The penetration of ofloxacin into lung tissue.
abstract: After a single oral 600 mg dose, ofloxacin concentrations were measured in lung tissue, whole blood and plasma in 11 patients undergoing thoracotomy for a bronchial malignancy. To correct for blood contamination in the tissue samples, the tissue haemoglobin content was measured using a method based on the binding of haemoglobin by haptoglobin. Ofloxacin concentrations in plasma and whole blood did not differ significantly. The calculated blood content in the tissue samples was 0.12 +/- 0.05 ml/g lung tissue. After correction for blood admixture, the mean lung tissue concentration 2 h after administration of ofloxacin was 17.7 +/- 9.2 micrograms/g. At the same time the mean plasma concentration was 8.7 +/- 4.2 mg/l (P less than 0.02). The high concentration of ofloxacin obtained in lung tissue does not result from the preparation technique. After a single 600 mg dose the tissue concentrations proved to exceed MIC values for most pathogens frequently involved in respiratory tract infections.
authors.affiliation: Department of Pulmonary Diseases, Foundation Deventer Hospital, The Netherlands.
authors.forename: W J
authors.initials: WJ
authors.lastname: Wijnands
authors.forename: T B
authors.initials: TB
authors.lastname: Vree
authors.forename: A M
authors.initials: AM
authors.lastname: Baars
authors.forename: J C
authors.initials: JC
authors.lastname: Hafkenscheid
authors.forename: B E
authors.initials: BE
authors.lastname: Kohler
authors.forename: C L
authors.initials: CL
authors.lastname: van Herwaarden
mesh_terms: D000368:Aged; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D015242:Ofloxacin