Gas chromatographic-mass spectrometric determination of levodropropizine plasma levels in healthy volunteers.
A gas chromatographic-mass spectrometric method for the qualitative and quantitative analysis of levodropropizine (S(-)-3-(4-phenyl-piperazin-1-yl)-propane-1,2-diol, DF 526) in plasma is described. The method proved to be highly selective and sensitive. Drug concentrations as low as 5 ng/ml could be measured. Levodropropizine plasma levels were measured in 6 healthy volunteers after administration of an acute 60 mg dose. Peak concentrations were reached between 40 and 60 min and measurable amounts of drug were present till 8 h after administration.
Zaratin
P
P
Institute of Pharmaceutical Sciences, University of Milan, Italy.
De Angelis
L
L
Cattabeni
F
F
D000284:Administration, Oral; D000328:Adult; D000996:Antitussive Agents / Q000008:administration & dosage / Q000097:blood*; D055598:Chemical Phenomena; D002621:Chemistry; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D011409:Propylene Glycols / Q000008:administration & dosage / Q000097:blood*; D012016:Reference Values
D000996:Antitussive Agents; D011409:Propylene Glycols; C035916:dipropizine