Comparative teratogenicity of triamcinolone acetonide and dexamethasone in the rhesus monkey (Macaca mulatta).
Pregnant rhesus macaques were treated with 0.5 or 2.5 mg/kg triamcinolone acetonide (TAC) or 1.0 or 10.0 mg/kg dexamethasone sodium phosphate (DEX) between 20 and 50 gestational days (GD). Treatment with TAC at 2.5 mg/kg resulted in a fetal loss of 71%; 3/5 recovered fetuses displayed an encephalocele or meningocele. All other treatment groups displayed minor cranial skeletal abnormalities consistent with glucocorticoid-mediated teratogenesis. DEX was shown to have a lower teratogenic potential than TAC in this species.
Jerome
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CP
Department of Comparative Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC.
Hendrickx
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AG
D000014:Abnormalities, Drug-Induced / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D001835:Body Weight; D001921:Brain / Q000473:pathology; D002508:Cephalometry; D003907:Dexamethasone / Q000009:adverse effects*; D004677:Encephalocele / Q000139:chemically induced; D005260:Female; D008251:Macaca; D008253:Macaca mulatta; D008588:Meningocele / Q000139:chemically induced; D008992:Monkey Diseases / Q000473:pathology*; D009929:Organ Size; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000662:veterinary; D012886:Skull / Q000002:abnormalities; D014222:Triamcinolone Acetonide / Q000009:adverse effects*
D003907:Dexamethasone; D014222:Triamcinolone Acetonide