title: Metabolism of 5-methyl-2-furaldehyde in rat. III. Identification and determination of 5-methyl-2-furylmethylketone.
abstract: 1. Continuous extraction, column chromatography and t.l.c. were employed to isolate a minor metabolite of 5-methyl-2-furaldehyde from rat urine. 2. The metabolite was identified by mass spectrometry and independent synthesis as 5-methyl-2-furylmethylketone. 3. A method for quantitative determination of the metabolite in urine was devised. About 7% of the parent compound was metabolized to 5-methyl-2-furylmethylketone.
authors.affiliation: Department of Toxicology, Academy of Medicine, Poznań, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Jodynis-Liebert
mesh_terms: D000818:Animals; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D005662:Furaldehyde / Q000031:analogs & derivatives* / Q000652:urine; D005663:Furans / Q000652:urine*; D007659:Ketones / Q000652:urine*; D008297:Male; D013058:Mass Spectrometry; D015394:Molecular Structure; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005663:Furans; D007659:Ketones; C057528:5-methyl-2-furylmethylketone; C048065:5-methyl-2-furfural; D005662:Furaldehyde