title: Altered gentamicin disposition in a child with a cavernous hemangioma.
abstract: Physiologic third spacing can cause an increase in the volume of distribution of certain drugs, such as aminoglycosides, which results in a decrease in the serum concentration. The case reported here, that of a child with a large cavernous hemangioma, demonstrated this phenomenon. To obtain adequate serum and tissue concentrations, alteration of antimicrobial dosing may be needed in similar cases.
authors.affiliation: Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock.
authors.forename: J B
authors.initials: JB
authors.lastname: Gillespie
authors.forename: S B
authors.initials: SB
authors.lastname: Mallory
authors.forename: G L
authors.initials: GL
authors.lastname: Kearns
authors.forename: R E
authors.initials: RE
authors.lastname: McCarthy
mesh_terms: D000671:Amputation, Surgical; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology; D002081:Buttocks / Q000002:abnormalities / Q000601:surgery; D005260:Female; D005839:Gentamicins / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006392:Hemangioma, Cavernous / Q000150:complications / Q000151:congenital / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007866:Leg / Q000002:abnormalities / Q000601:surgery
chemical_list: D005839:Gentamicins