Different effects of 2-deoxy-sugars on memory formation.
When rats were trained on a brightness discrimination task, intrahippocampal injections of 2-deoxy-galactose interfered with long-term memory formation while galactose and 2-deoxy-glucose were ineffective altogether. No differences were found in the morphology of hippocampal CA1 neurons investigated light-microscopically after application of the sugars. The amnestic action of 2-deoxy-galactose is discussed in the light of a rather specific interference with fucosylation of proteoglycans involved in mechanisms underlying the formation of a memory trace.
Grecksch
G
G
Institute of Pharmacology and Toxicology, Medical Academy Magdeburg, DDR.
Pohle
W
W
Jork
R
R
Matthies
H
H
D000818:Animals; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects; D004558:Electric Stimulation; D005643:Fucose / Q000494:pharmacology*; D005690:Galactose / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D008297:Male; D008568:Memory / Q000187:drug effects*; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains
D003837:Deoxy Sugars; D005643:Fucose; D003847:Deoxyglucose; D005690:Galactose