[Changes in the lipid component of liver microsomal membranes during the postischemic period after administration of alpha-tocopherol and lidocaine].
Administration of alpha-tocopherol in combination with lidocaine prevented distinct alterations in lipid component of liver microsomal membranes of rats during the restoration period after 30 min total ischemia of liver tissue. These drugs reduced the ratio of saturated and unsaturated fatty acids down to the initial level within 3 days after ischemia, whereas the alterations in fatty acid composition were maintained within 21 days of the restoration period in control experiment. Considerable alterations in the patterns of fluorescent probe ANS binding with microsomal membranes during the postischemic period were not observed after administration of the drugs. Protective effect of the drugs involved transformation of lipid component in microsomal membranes.
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D000818:Animals; D004359:Drug Therapy, Combination; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005456:Fluorescent Dyes; D007425:Intracellular Membranes / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism* / Q000517:prevention & control; D008012:Lidocaine / Q000008:administration & dosage*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000098:blood supply*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014810:Vitamin E / Q000008:administration & dosage*
D005227:Fatty Acids; D005456:Fluorescent Dyes; D008563:Membrane Lipids; D014810:Vitamin E; D008012:Lidocaine
Izmeneniia lipidnogo komponenta mikrosomal'nykh membran pecheni v postishemicheskom periode pri vvedenii alpha-tokoferola i lidokaina.