[Evaluation of the capacity of the thymus to accumulate testosterone and of the nature of its interaction with the thymocytes].
It was found out that thymus accumulated 3H-testosterone from blood at the same degree as liver, prostate and skeletal muscle. However, hormone was quickly eliminated from the thymus and prostate accumulated it. Thymocytes bound about 5% of testosterone accumulated by the organ. The dependence of binding of 3H-testosterone by thymocytes in vitro and the absence of competition between labelled and unlabelled forms of hormone were revealed. The results obtained make it possible to conclude that thymocytes lack the systems of specific binding of androgen.
Chermnykh
N S
NS
Ukhina
T V
TV
Andreev
Iu A
IuA
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009919:Orchiectomy; D051381:Rats; D013739:Testosterone / Q000378:metabolism* / Q000494:pharmacology; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution; D014316:Tritium
D014316:Tritium; D013739:Testosterone
Otsenka sposobnosti timusa akkumulirovat' testosteron i kharaktera vzaimodeĭstviia ego s timotsitami.