A novel method for the sampling of synovial fluid in mice. Assay of a synovial lysosomal enzyme in zymosan-induced arthritis.
A novel and very useful technique was developed to assay a lysosomal enzyme released into the joint synovial fluid during zymosan-induced arthritis in mice. This beta-glucuronidase activity correlated with histomorphological changes observed in the joint: vasculitis, synovitis and pannus formation. The antiarthritic drug triamcinolone acetonide improved both biochemical and histological parameters.
Folliard
F
F
Immunological Unit, Rhône-Poulenc Santé, Vitry-sur-Seine, France.
Terlain
B
B
D000818:Animals; D001168:Arthritis / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D005089:Exocytosis; D005260:Female; D005966:Glucuronidase / Q000032:analysis*; D008247:Lysosomes / Q000201:enzymology; D051379:Mice; D013582:Synovial Fluid / Q000201:enzymology*; D014222:Triamcinolone Acetonide / Q000627:therapeutic use; D015054:Zymosan
D015054:Zymosan; D005966:Glucuronidase; D014222:Triamcinolone Acetonide