title: [Treatment of hypertensive attacks in children with nicardipine].
abstract: A prospective study of the hypotensive effects of nicardipine has been performed during 65 administrations of the drug in 6 children with malignant hypertension. We conclude that this calcium channel blocker is useful to treat hypertensive emergency in children owing to its tolerance and its efficacy (mean arterial blood pressure was lowered by 28 to 38% after 90 min). In addition, it ensures the maintenance of cerebral, renal and myocardial blood flow. A posology of 1 mg/kg/dose, 3 or 4 times/day (oral route) seems to be sufficient, as its effects last 6 to 10 h. Nevertheless the control of acute arterial hypertension must always be associated with the introduction or adjustment of long-term antihypertensive therapy.
authors.affiliation: Unité de réanimation, hôpital Edouart-Herriot, France.
authors.forename: C
authors.initials: C
authors.lastname: Buttet
authors.forename: P
authors.initials: P
authors.lastname: Cochat
authors.forename: D
authors.initials: D
authors.lastname: Floret
authors.forename: J
authors.initials: J
authors.lastname: Malfroy
authors.forename: L
authors.initials: L
authors.lastname: David
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D009529:Nicardipine / Q000627:therapeutic use*; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D009529:Nicardipine
vernacular_title: Traitement des poussées hypertensives de l'enfant par la nicardipine.