title: [Pericardial effusion during the therapy of Crohn's disease with 5-aminosalicylic acid].
abstract: A 22-year-old woman with Crohn's disease was treated with 5-aminosalicylic acid (Claversal), four times 500 mg daily, because of increased inflammatory activity. Retrosternal pain set in after two weeks; in another two weeks a moderately enlarged heart was noted on the chest X-ray and pericardial effusion diagnosed echocardiographically. After stopping the medication the pericardial effusion resolved without further treatment. Immunoserology failed to demonstrate autoantibodies, but a repeat lymphocyte stimulation test was positive. There is a possible causal relationship between 5-aminosalicylic acid medication and the pericardial effusion, although the pathogenetic mechanisms is not known.
authors.affiliation: Abteilung I und II, Universität Tübingen.
authors.forename: P
authors.initials: P
authors.lastname: Weber
authors.forename: E W
authors.initials: EW
authors.lastname: Becker
authors.forename: H
authors.initials: H
authors.lastname: Jenss
mesh_terms: D000328:Adult; D000636:Aminosalicylic Acids / Q000009:adverse effects*; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D019804:Mesalamine; D010490:Pericardial Effusion / Q000139:chemically induced* / Q000175:diagnosis; D013997:Time Factors
chemical_list: D000636:Aminosalicylic Acids; D019804:Mesalamine
vernacular_title: Perikarderguss während der Therapie eines Morbus Crohn mit 5-Aminosalicylsäure.