The cortical activity in experimental subarachnoid hemorrhage.
Based on a new subarachnoid hemorrhage model in rabbits, the electrocortical activity was evaluated over a period of one week following two successive whole blood injections in the cisterna magna. A second group was injected with artificial cerebrospinal fluid, while a third group with hemolyzed autologous blood. All the other procedures being the same, it became evident that elevated intracranial pressure (CSF injection) is not able by itself to induce true epileptiform activity; however, it releases phenomena of brainstem reflexes. During whole blood injection, the cortical activity showed a peak in true epileptogenic discharges 5 days after the first injection. Almost identical polyspikes and slow wave complexes were reproduced immediately after the injection of hemolyzed blood. The possible mechanisms involved in the appearance of these phenomena are further discussed.
Karacostas
D
D
Aristotelian University, B' Department of Neurology, AHEPA Hospital, Thessaloniki, Greece.
Baker
K
K
Lagree
K
K
Milonas
J
J
Zervas
N T
NT
D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000209:etiology* / Q000503:physiopathology; D011817:Rabbits; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000503:physiopathology*