Parametric studies on phencyclidine enhancement of 3H quinuclidinyl benzilate accumulation in vivo.
The purpose of these experiments was to define the temporal parameters involved in the phencyclidine (PCP) enhancement of 3H quinuclidinyl benzilate (QNB) accumulation in mouse brain. PCP enhanced QNB accumulation in brain if given intraperitoneally (IP) 1 and 4, but not 16 hours before intravenous (IV) administration of QNB. This effect was found in hypothalamus, striatum, cortex and hippocampus, but not cerebellum. PCP given after QNB did not alter QNB accumulation. The PCP enhancement persisted for at least 72 hours after QNB administration. These results confirm previous studies demonstrating that PCP must be present prior to QNB administration to enhance the accumulation and show that the effect persists for an extended period of time.
Boggan
W O
WO
Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Charleston 29425-0742.
Faught
K
K
Boyd
S
S
Middaugh
L D
LD
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002855:Chromatography, Thin Layer; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010622:Phencyclidine / Q000494:pharmacology*; D011812:Quinuclidines / Q000378:metabolism*; D011813:Quinuclidinyl Benzilate / Q000097:blood / Q000378:metabolism*; D011869:Radioligand Assay; D011976:Receptors, Muscarinic / Q000187:drug effects*; D013048:Specimen Handling
D011812:Quinuclidines; D011976:Receptors, Muscarinic; C028484:quinuclidinyl benzilate receptor; D011813:Quinuclidinyl Benzilate; D010622:Phencyclidine