Interferon-beta induced remission in a hairy cell leukemia patient resistant to interferon-alpha.
Two patients with advanced hairy cell leukemia and pancytopenia responded successfully to intramuscular injections of recombinant interferon-beta, with normalisation of blood counts. One of the patients had developed resistance to interferon-alpha. The in-vivo response was predicted by in-vitro studies showing a beneficial effect of IFN-beta on erythropoiesis in cell cultures derived from these patients.
Michalevicz
R
R
Institute of Hematology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Rehovot, Israel.
Aderka
D
D
Frisch
B
B
Revel
M
M
D001853:Bone Marrow / Q000473:pathology; D004351:Drug Resistance; D004920:Erythropoiesis / Q000187:drug effects; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology / Q000627:therapeutic use*; D007943:Leukemia, Hairy Cell / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D012074:Remission Induction; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014410:Tumor Stem Cell Assay
D007370:Interferon Type I; D011994:Recombinant Proteins