Non-random chromosomal aberrations in a complex leukaemic clone of a Bloom's syndrome patient.
Bloom's syndrome is one of the congenital disorders known to have increased frequency of acute leukaemia. The complex cytogenetic findings in the leukaemic cells of a 39-year-old male with Bloom's syndrome are described. These included a translocation t(7;17), missing 7q and 17p, a reciprocal translocation t(4;22); del 3q, del 8q22, del 20q, missing 12 and missing Y. In the same patient a missing Y had been noted 10 years previously in 15% of his peripheral blood lymphocytes.
Shabtai
F
F
Gattegno Research Institute for Human Reproduction and Fetal Development, Hasharon Hospital, Golda Medical Center, Tel Aviv University Medical School, Petah-Tiqva, Israel.
Lewinski
U H
UH
Meroz
A
A
Klar
D
D
Djaldetti
M
M
Halbrecht
I
I
D000208:Acute Disease; D000328:Adult; D001816:Bloom Syndrome / Q000150:complications / Q000235:genetics*; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002873:Chromosome Fragility; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000209:etiology / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic