title: Renal growth and progression of reflux nephropathy in children with vesicoureteral reflux.
abstract: We analyzed renal growth and development of renal scars in 754 children with primary and 169 with secondary vesicoureteral reflux. The incidence of a small kidney was 15.5 per cent in the primary and 24.1 per cent in the secondary groups. About three-fourths of the small kidneys remained small from the first examination through followup. Catch-up renal growth was only exceptional. New scars or progression of previous scarring was observed in 7.4 and 30 per cent of the primary and secondary groups, respectively. Factors that promote formation of new scars are high grade vesicoureteral reflux, recurrent urinary tract infections and abnormal bladder function that results in high pressure reflux. We emphasized the importance of precise examination of the lower urinary tract. An early antireflux operation should be performed on children with severe reflux or recurrent urinary tract infections.
authors.affiliation: Department of Urology, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shimada
authors.forename: T
authors.initials: T
authors.lastname: Matsui
authors.forename: T
authors.initials: T
authors.lastname: Ogino
authors.forename: M
authors.initials: M
authors.lastname: Arima
authors.forename: Y
authors.initials: Y
authors.lastname: Mori
authors.forename: F
authors.initials: F
authors.lastname: Ikoma
mesh_terms: D002648:Child; D002675:Child, Preschool; D002921:Cicatrix / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007668:Kidney / Q000254:growth & development* / Q000473:pathology / Q000601:surgery; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology; D008297:Male; D011184:Postoperative Period; D001743:Urinary Bladder / Q000503:physiopathology; D014552:Urinary Tract Infections / Q000150:complications; D014718:Vesico-Ureteral Reflux / Q000150:complications / Q000503:physiopathology* / Q000601:surgery