Plasmodium chabaudi malaria: protective immunization with surface membranes of infected erythrocytes.
Plasmodium chabaudi-susceptible NMRI and B10.A mice were vaccinated with host cell plasma membranes isolated from P. chabaudi-infected erythrocytes. Most of the mice were protected from the lethal consequences of challenge with the homologous parasite, although protection was unassociated with a reduction in the course or peak of parasitemia. Vaccination also induced the production of antibodies against Pc90, which is the immunodominant protein expressed by parasites in host cell plasma membranes.
Wunderlich
F
F
Division of Parasitology, University of Duesseldorf, Federal Republic of Germany.
Brenner
H H
HH
Helwig
M
M
D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D000953:Antigens, Protozoan / Q000032:analysis; D015153:Blotting, Western; D004910:Erythrocyte Membrane / Q000276:immunology*; D008288:Malaria / Q000517:prevention & control*; D051379:Mice; D008970:Molecular Weight; D010961:Plasmodium; D014611:Vaccination
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan