title: Hamartomatous solitary polyp with malignant progression in the jejunum. A histochemical and immunohistochemical study by light and electron microscopy.
abstract: A case of solitary hamartomatous jejunal polyp with adenomatous and carcinomatous changes in a 16-year-old girl is reported. In the hamartomatous polyp, neutral and acid non-sulfate mucosubstance was detected, principally in goblet cells; carcinoembryonic antigen was demonstrated on the surfaces of the microvilli and luminal border of the crypts and glands; absorptive columnar, goblet, argentaffin, argyrophil and Paneth cells were evident. The adenomatous and, mainly, the carcinomatous areas revealed a decreased amount of mucosubstance and a variable degree of positive intracytoplasmic staining for carcinoembryonic antigen. With electron microscopy, the adenomatous areas showed columnar absorptive cells and mucus-secreting goblet cells; also immature columnar cells were observed in the dysplastic zones. To our knowledge, this is the first study to document the histochemical, immunohistochemical and ultrastructural features of a hamartomatous polyp with neoplastic transformation.
authors.affiliation: Department of Pathology, University of Granada, School of Medicine, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Aneiros
authors.forename: M
authors.initials: M
authors.lastname: Matamala
authors.forename: R
authors.initials: R
authors.lastname: Garcia del Moral
authors.forename: J J
authors.initials: JJ
authors.lastname: Lopez
authors.forename: D
authors.initials: D
authors.lastname: Aguilar
authors.forename: M
authors.initials: M
authors.lastname: Camara
mesh_terms: D000293:Adolescent; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005260:Female; D006222:Hamartoma / Q000175:diagnosis / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007417:Intestinal Polyps / Q000175:diagnosis / Q000473:pathology*; D007580:Jejunal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008854:Microscopy, Electron