Induction of lipid peroxidation in tissues of thallous malonate-treated hamster.
Thallous malonate was administered orally to hamsters in a single dose of 10 mg Tl/kg or 50 mg Tl/kg body weight. After 1 day and 3 days the levels of lipid peroxidation and non-protein sulfhydryls (NPSH) and glutathione peroxidase (GSH-Px) activity in tissues were measured. At a thallium dose of 10 mg/kg, increases in lipid peroxidation were already apparent in the kidney after 1 day. On the other hand, a marked increase in lipid peroxidation with decrease in NPSH content and GSH-Px activity in the kidney and liver were found 3 days after administration of the 50 mg Tl/kg dose, and renal and liver damage also developed. These results suggested that thallous malonate-induced tissue damage may be associated with the development of peroxidative processes caused by depression of GSH and inhibition of the GSH-Px activity-linked defensive system.
Aoyama
H
H
Department of Public Health, St. Marianna University School of Medicine, Kawasaki, Japan.
Yoshida
M
M
Yamamura
Y
Y
D000818:Animals; D001921:Brain / Q000378:metabolism; D006224:Cricetinae; D005979:Glutathione Peroxidase / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D008297:Male; D008314:Malonates / Q000493:pharmacokinetics / Q000633:toxicity*; D008315:Malondialdehyde / Q000378:metabolism; D008647:Mesocricetus; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013737:Testis / Q000378:metabolism; D013793:Thallium / Q000493:pharmacokinetics / Q000633:toxicity*
D008314:Malonates; D013438:Sulfhydryl Compounds; D008315:Malondialdehyde; C030290:malonic acid; D013793:Thallium; D005979:Glutathione Peroxidase