Unchanged regional norepinephrine glycol metabolite levels in rat brain two months after amygdala kindling.
Concentrations of the norepinephrine (NE) glycol metabolites MHPG (3-methoxy-4-hydroxyphenylethyleneglycol) and DHPG (3,4-dihydroxyphenylethyleneglycol) were examined in 13 brain regions of amygdala-kindled and yoked control rats. The subjects were killed 2 months after the kindled rats had exhibited their sixth 'stage 4-5' generalized seizure. In experiment 1, small but statistically significant decreases in total MHPG levels were found in the right hippocampus (91.6% of control) and hypothalamus (90.7% of control). When the study was repeated with 2 additional control groups, non-kindled, electrically stimulated controls and maximal electroshock convulsion controls, however, these small changes were not seen. The data suggest that since amygdala kindling does not produce any consistent, long-lasting alterations in brain regional NE glycol metabolite levels, there are no consistent, long-term changes in central NE neuronal activity.
Okazaki
M M
MM
Dept. of Pharmacology, University of Toronto, Ont., Canada.
Warsh
J J
JJ
Burnham
W M
WM
D000679:Amygdala / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D006018:Glycols / Q000378:metabolism*; D007696:Kindling, Neurologic; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D006018:Glycols; D008734:Methoxyhydroxyphenylglycol; C010117:3,4-dihydroxyphenylglycol