[Comparative study of the anticoagulant activity of sulfated polysaccharides from marine brown algae].
A comparative study of the anticoagulant activity of fucoidan, sulfated polysaccharides of brown sea algae, was carried out during in vitro and in vivo experiments. Among the compounds of this class of nonlinear polyanions of sea algae there were detected the substances possessing a low toxicity and anticoagulant activity comparable with that of heparin. However the mechanism of action of the studied compounds differs from that of heparin.
Rozkin
M Ia
MIa
Levina
M N
MN
Efimov
V S
VS
Usov
A I
AI
D000818:Animals; D000925:Anticoagulants / Q000032:analysis / Q000494:pharmacology* / Q000633:toxicity; D001777:Blood Coagulation / Q000187:drug effects; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D056890:Eukaryota; D006493:Heparin / Q000494:pharmacology; D008297:Male; D051379:Mice; D000459:Phaeophyceae; D011134:Polysaccharides / Q000032:analysis / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D013918:Thrombin Time; D013921:Thrombocytopenia / Q000139:chemically induced; D013997:Time Factors
D000925:Anticoagulants; D011134:Polysaccharides; D006493:Heparin; C007789:fucoidan
Sravnitel'noe issledovanie antikoaguliantnoĭ aktivnosti sul'fatirovannykh polisakharidov burykh morskikh vodorosleĭ.