Periampullary, colorectal and gastric cancer in two siblings.
We describe a sibship affected by subsequent periampullary, colorectal and gastric carcinoma. Three of 4 siblings (2 males, 1 female) developed a periampullary carcinoma at the age of 20, and the 2 brothers subsequently had colorectal and gastric carcinoma. One of them also had familial adenomatous polyposis. There is suggestive evidence of vertical transmission of a gene predisposing to a hereditary colorectal carcinoma syndrome.
Schlossberg
D
D
Chirurgische Abteilung, Stadtspital Waid, Zürich, Switzerland.
Weber
W
W
Stoffel
U
U
Henggeler
K
K
Stocker
H
H
Foeppl
M
M
Akovbiantz
A
A
D000328:Adult; D014670:Ampulla of Vater; D015179:Colorectal Neoplasms / Q000235:genetics*; D003138:Common Bile Duct Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics*