[The molecular mechanism of the antiviral action of 2-(1'-aminoethyl)-bicyclo (2.2.1) heptane hydrochloride].
The interaction of 2-(1'-aminoethyl)-bicyclo (2.2.1) heptane hydrochloride possessing anti-influenza activity with flat bilayer lipid membranes was studied. The compound was shown to adsorb and build-in into the lipid bilayer changing the charge, modulus of transverse elasticity, and ion permeability of the membranes. Pre-addition of the preparation into the medium washing the membrane prevents interaction of influenza virus matrix protein with the membrane. The compound also destroys M-protein aggregates in the aqueous phase. The possible role of the observed effect of the compound in its antiviral action is discussed.
Fedorov
A N
AN
El-Karadagi
S
S
Rusiaev
V A
VA
Kharitonenkov
I G
IG
Tverdislov
V A
VA
D000327:Adsorption; D000998:Antiviral Agents / Q000494:pharmacology*; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D004347:Drug Interactions; D004548:Elasticity; D066298:In Vitro Techniques; D008051:Lipid Bilayers / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009636:Norbornanes / Q000494:pharmacology*; D009975:Orthomyxoviridae / Q000187:drug effects; D014763:Viral Matrix Proteins / Q000494:pharmacology
D000998:Antiviral Agents; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D008051:Lipid Bilayers; D009636:Norbornanes; D014763:Viral Matrix Proteins; C034486:2-(1'-aminoethyl)bicyclo(2.2.1)heptane
Issledovanie molekuliarnogo mekhanizma protivovirusnogo deĭstviia 2-(1'-aminoétil)-bitsiklo (2.2.1) geptan gidrokhlorida.