title: Biovailability and pulmonary first-pass removal of etretinate in rats.
abstract: The oral biovailability of etretinate (ET) and its presystemic loss due to pulmonary extraction were studied in the rat. The oral biovailability was found to be 15%. The percentage of a dose of ET escaping pulmonary extraction was estimated to be 49%. These data suggest substantial presystemic loss of ET, including significant extraction by the lungs.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis 55455.
authors.forename: P
authors.initials: P
authors.lastname: Thongnopnua
authors.forename: C L
authors.initials: CL
authors.lastname: Zimmerman
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D005050:Etretinate / Q000378:metabolism / Q000493:pharmacokinetics*; D008168:Lung / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005050:Etretinate