[Effect of the antioxidant fenozan on the physicochemical properties of the kidney cell membranes of rats during nitrosodimethylamine-induced carcinogenesis].
The lipid peroxidation level, microviscosity and arrangement of lipid bilayer in mitochondria and microsomal membranes of kidney cell in rats were increased a month after the treatment with carcinogenic nitrosodimethylamine. The additional injection of antioxidant fenozan-1K prevented the activation of lipid peroxidation in early stage of carcinogenesis and decreased the microviscosity and arrangement of membrane lipids both in early and progressive stages of carcinogenesis, and inhibited the carcinogenic process in the kidneys.
Khokhlov
A P
AP
Kirillov
V N
VN
D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004128:Dimethylnitrosamine / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D008051:Lipid Bilayers / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D010666:Phenylpropionates / Q000494:pharmacology / Q000627:therapeutic use*; D013113:Spin Labels; D013997:Time Factors
D000975:Antioxidants; D008051:Lipid Bilayers; D010666:Phenylpropionates; D013113:Spin Labels; D004128:Dimethylnitrosamine; C047854:fenozan
Vliianie antioksidanta fenozana na fiziko-khimicheskie svoĭstva membran kletok pochek krys pri kantserogeneze, indutsirovannom nitrozodimetilaminom.