title: Cholestatic effect of cyclosporine in the rat. An inhibition of bile acid secretion.
abstract: Cyclosporine administration in patients with organ transplants may cause cholestasis. In the rat, intraperitoneal administration of cyclosporine, 10 mg/kg, for three weeks did not cause liver function test abnormalities or hepatic histological lesions. However a significant reduction of bile flow and bile acid secretion rates was observed. The fact that reduction of bile flow was related to a decrease of the bile acid-independent flow suggests that cyclosporine-induced cholestasis results from an inhibition of bile acid secretion. Whether this inhibition is caused by the parental molecule or by cyclosporine metabolites needs to be clarified.
authors.affiliation: Laboratoire de Recherche Chirurgicale, Hôpital Cochin, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Le Thai
authors.forename: M
authors.initials: M
authors.lastname: Dumont
authors.forename: A
authors.initials: A
authors.lastname: Michel
authors.forename: S
authors.initials: S
authors.lastname: Erlinger
authors.forename: D
authors.initials: D
authors.lastname: Houssin
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002779:Cholestasis / Q000139:chemically induced*; D003524:Cyclosporins / Q000494:pharmacology*; D003864:Depression, Chemical; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D001647:Bile Acids and Salts; D003524:Cyclosporins