A case of sotalol poisoning with fatal outcome.
The case of a 58 year old woman who died after ingestion of 14.4 g of sotalol and 50 mg of triazolam is described. Despite medical treatment, intracardiac pacing and hemodialysis, cardiovascular failure persisted and became irreversible. High sotalol concentrations were observed in plasma (65 micrograms/ml) and in post mortem tissues samples. Tissue to plasma ratios ranged from 2.5 to 6. The high drug concentration found in heart tissue (104.4 micrograms/g) explains the difficulties experienced in the sotalol poisoning.
Perrot
D
D
Department of Intensive Care Medicine, Hôpital Edouard Herriot, Lyon.
Bui-Xuan
B
B
Lang
J
J
Bouffard
Y
Y
Delafosse
B
B
Faucon
G
G
Motin
J
J
D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008875:Middle Aged; D013015:Sotalol / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D013405:Suicide; D014018:Tissue Distribution
D013015:Sotalol