title: [Emotional reactivity of rats and their progeny after hormonal modification of intrauterine development].
abstract: Emotional reactivity of two rat generations was estimated in open field test and by the corticosteroids level under motor restriction after hydrocortisone injections (50 mg/kg) to their mothers (the 1st generation) or grandmothers (the 2nd generation) on 16 and 18 days of gestation. The 3-, 6- or 12-month-old males and females of the 1st generation had decreased emotional reactivity. On the contrary, the animals of the 2nd generation had increased defecation, but decreased ambulation scores in the open field test, that characterised them as more emotional in comparison to the control rats. Thus, the corticosteroids can be a factor of "nongenetic transmission of information" in the development of animals' emotional reactivity mechanisms.
authors.forename: N N
authors.initials: NN
authors.lastname: Dygalo
mesh_terms: D000305:Adrenal Cortex Hormones / Q000097:blood; D000375:Aging / Q000187:drug effects; D000818:Animals; D004644:Emotions / Q000187:drug effects*; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology
chemical_list: D000305:Adrenal Cortex Hormones; D006854:Hydrocortisone
vernacular_title: Emotsional'naia reaktivnost' krys i ikh potomstva posle gormonal'noĭ modifikatsii vnutriutrobnogo razvitiia.