title: Scanned focussed ultrasound hyperthermia: initial clinical results.
abstract: Between November 1986 and July, 1987, a preliminary study to determine the feasibility of scanned focussed ultrasound for clinical hyperthermia at various sites was conducted. Fourteen patient (17 tumors) have been treated using a microprocessor-controlled apparatus developed at the University of Arizona by modifying a commercially available diagnostic ultrasound unit. We have treated nine pelvic tumors, four extremity tumors, two brain tumors, and two extracranial head and neck tumors for a total of 42 treatments. Multipoint thermometry was achieved for all patients, with 2-25 (mean = 10) points monitored during each treatments within the scanned tumor volume. Average maximum temperature within the scanned tumor volume was 44.2, 44.7, 44.8, and 42.0 degrees C for pelvic, extremity brain, and extracranial head and neck tumors, respectively; similarly, 55%, 45%, 71%, and 0 of monitored points exceeded 42.5 degrees C. Pain limited applied power in 15 of 42 treatments, and bone pain with a periodicity similar to the scanning periodicity was seen in 11 treatments. A non-randomized comparison of temperatures achieved using scanned focussed ultrasound to those achieved using the microwave annular array and the CDRH Helix suggests that scanned focussed ultrasound may have promise and potential advantages in heating selected pelvic tumors.
authors.affiliation: Department of Radiation Oncology, Arizona Cancer Center, University of Arizona College of Medicine, Tucson 85724.
authors.forename: D S
authors.initials: DS
authors.lastname: Shimm
authors.forename: K H
authors.initials: KH
authors.lastname: Hynynen
authors.forename: D P
authors.initials: DP
authors.lastname: Anhalt
authors.forename: R B
authors.initials: RB
authors.lastname: Roemer
authors.forename: J R
authors.initials: JR
authors.lastname: Cassady
mesh_terms: D001932:Brain Neoplasms / Q000628:therapy; D005121:Extremities; D006258:Head and Neck Neoplasms / Q000628:therapy; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D010386:Pelvic Neoplasms / Q000628:therapy; D014464:Ultrasonic Therapy / Q000295:instrumentation