[Controlled study of the administration of CDP-choline to preterm newborn infants with respiratory distress syndrome].
A randomized prospective double-blind trial of CDP-Choline administration to a group of 24 preterm newborn infants with respiratory distress syndrome is reported. CDP-choline was administered by the intravenous route (100 mg/kg/day) for seven days, or until less than 30% supplemental oxygen was needed. By the fifth day of life, the patients who received CDP-choline required oxygen for a longer period of time, and had a lower lecithin/sphingomyelin ratio and palmitic acid percentage than those in the control group. At the dose given, CDP-choline did not induce postnatal pulmonary maturity. In fact, it may even decrease lecithin synthesis.
Valls i Soler
A
A
Departamento de Pediatría, Universidad del Pais Vasco, Hospital Infantil de Cruces, Baracaldo, Vizcaya.
Sanjurjo
P
P
Vázquez Cordero
C
C
D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D007231:Infant, Newborn; D010102:Oxygen Inhalation Therapy; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000032:analysis; D010713:Phosphatidylcholines / Q000032:analysis; D011446:Prospective Studies; D011663:Pulmonary Surfactants / Q000032:analysis; D011897:Random Allocation; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy* / Q000503:physiopathology; D013109:Sphingomyelins / Q000032:analysis
D010169:Palmitic Acids; D010713:Phosphatidylcholines; D011663:Pulmonary Surfactants; D013109:Sphingomyelins; D019308:Palmitic Acid; D003566:Cytidine Diphosphate Choline; D002794:Choline
Estudio controlado sobre la adminstración de CPD-colina a recién nacidos pretérmino con síndrome de dificultad respiratoria.