title: Growth related changes in protein synthesis and in a 25 kDa protein of Ehrlich ascites tumor cells.
abstract: The decrease of the in vivo growth rate of the Ehrlich ascites tumor after intraperitoneal injection of carcinoma cells into mice is correlated with (1) a decline in the overall rate of cellular protein synthesis, (2) a corresponding decrease of the activity of the cytosolic fraction to stimulate in vitro polysomal protein synthesis, (3) the abundance and phosphorylation of a 25 kDa protein. The results are discussed with respect to correlations between the regulation of protein synthesis and cell proliferation.
authors.affiliation: Department of Cell Physiology, Academy of Sciences of the GDR, Berlin Buch.
authors.forename: H
authors.initials: H
authors.lastname: Bielka
authors.forename: R
authors.initials: R
authors.lastname: Benndorf
authors.forename: I
authors.initials: I
authors.lastname: Junghahn
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002455:Cell Division; D003600:Cytosol / Q000502:physiology; D015180:Electrophoresis, Gel, Two-Dimensional; D051379:Mice; D008813:Mice, Inbred ICR; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009368:Neoplasm Transplantation; D010766:Phosphorylation; D011132:Polyribosomes / Q000378:metabolism
chemical_list: D009363:Neoplasm Proteins