The effects of beta-adrenergic drugs on the human sperm motility in vitro. II. The effects of isoprenaline and fenoterol.
Thirty semen samples from men with asthenozoospermia were divided into three groups. 0.025 mM of Isoprenaline and 0.65 x 10(-2) mM Fenoterol were added to the first group, a double dose to the second one and five times higher dose to the last one. The lowest concentration used in our experiment results from the applied intravenous therapeutic doses for people. The sperm motility was evaluated under phase-contrast microscope in the 5, 30, 60, 120 and 240 minute of the experiment. The lowest doses of both drugs were most active in relation to the sperm motility in 120 minute after their administration, but the effect appeared to be much higher for Isoprenaline. Isoprenaline resulted in the higher increase of the sperm motility after the addition of the double dose in 240 Minute of the experiment. The effects of the applied B-adrenergic drugs on the sperm motility were discussed.
Semczuk
M
M
Department of Obstetrics and Gynecology, Medical Academy of Lublin/Poland.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D005280:Fenoterol / Q000494:pharmacology*; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D013081:Sperm Motility / Q000187:drug effects*
D005280:Fenoterol; D007545:Isoproterenol