title: Successful treatment of pulmonary embolism and associated mobile right atrial thrombus with use of a central thrombolytic infusion.
abstract: Patients with pulmonary embolism and two-dimensional echocardiographic evidence of right atrial thrombus have a high mortality rate despite standard anticoagulation therapy. We used a direct central infusion of streptokinase in three such patients, who subsequently had rapid and complete clinical improvement. In this setting, thrombolytic therapy should be considered an effective therapeutic option.
authors.affiliation: Division of Gastroenterology and Internal Medicine, Mayo Clinic, Rochester, MN 55905.
authors.forename: M
authors.initials: M
authors.lastname: Proano
authors.forename: J K
authors.initials: JK
authors.lastname: Oh
authors.forename: R L
authors.initials: RL
authors.lastname: Frye
authors.forename: C M
authors.initials: CM
authors.lastname: Johnson
authors.forename: A J
authors.initials: AJ
authors.lastname: Tajik
authors.forename: C P
authors.initials: CP
authors.lastname: Taliercio
mesh_terms: D000328:Adult; D000368:Aged; D002405:Catheterization, Central Venous; D004452:Echocardiography; D005260:Female; D006325:Heart Atria; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery; D011655:Pulmonary Embolism / Q000188:drug therapy*; D013300:Streptokinase / Q000627:therapeutic use*; D013927:Thrombosis / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D013300:Streptokinase