Effect of carrier erythrocytes containing inositol hexaphosphate on Babesia microti infection.
Erythrocytes containing inositol hexaphosphate (IHP) were administered to mice. Mice were then challenged with Babesia microti. Mice receiving IHP carrier erythrocytes had significantly lower percentages of parasitaemias on days 3, 5 and 7 after infection. Carrier erythrocytes containing IHP have altered P50 oxygen values. Thus, carrier erythrocytes containing IHP may be useful in treating naive animals before transporting into areas endemic for babesiosis.
Deloach
J R
JR
USDA, Agriculture Research Service, College Station, Texas 77841.
Corrier
D E
DE
Wagner
G G
GG
D000818:Animals; D001403:Babesia / Q000187:drug effects; D001404:Babesiosis / Q000097:blood* / Q000469:parasitology; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D010833:Phytic Acid / Q000494:pharmacology*
D010833:Phytic Acid