Epidemiological studies of onchocerciasis in forest villages of Sierra Leone.
Results are presented for five villages in the forest zone of Sierra Leone in which forest onchocerciasis was considered to be a significant health problem. All five villages were found to be hyperendemic and 85% (682/803) of persons were found to have at least one sign of onchocerciasis. The emergence of microfilariae from skin snips (iliac crest and/or canthus) or the presence of nodules accounted for 96.5% of all persons positive for onchocerciasis. The prevalence of nodules from all body sites was 70.5% and of elephantiasis, hanging groin and skin lesions (moderate and severe) was 0.4%, 0.3% and 5.3% respectively. Analysis of eye lesions (the most serious clinical manifestation of the disease) was restricted to persons aged 30 years and over since this gives a better indication of the public health importance of onchocerciasis than analysis in the overall population. This gave prevalence rates of onchocercal blindness of 4.5% (both eyes) and 2.8% (one eye only). Rates for the four potentially blinding eye lesions were sclerosing keratitis (4.1%), iritis (16.5%), optic atrophy (13.8%) and choroidoretinitis (14.4%). Rates in males were approximately twice as high as those in females.
McMahon
J E
JE
MRC Laboratory, Bo, Sierra Leone.
Sowa
S C
SC
Maude
G H
GH
Hudson
C M
CM
Kirkwood
B R
BR
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D001766:Blindness / Q000453:epidemiology / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D002825:Chorioretinitis / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D007634:Keratitis / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009854:Onchocerca / Q000302:isolation & purification; D009855:Onchocerciasis / Q000453:epidemiology* / Q000635:transmission; D009896:Optic Atrophy / Q000453:epidemiology / Q000209:etiology; D012424:Rural Population; D012737:Sex Factors; D012807:Sierra Leone; D012867:Skin / Q000469:parasitology