Identification of two suppressor factors induced by early pregnancy factor.
The binding of EPF to lymphocytes stimulates the release of soluble mediators, active in T cell dependent reactions, namely the rosette inhibition test and the adoptive transfer of contact sensitivity. On the basis of their ability to inhibit the delayed type hypersensitivity reaction in this latter assay, they have been classified as suppressor factors. This paper describes the identification of two EPF-induced suppressor factors. Unlike EPF which is neither species-restricted nor strain-restricted, these factors are genetically restricted in their action in the rosette inhibition test. EPF-S1 (estimated Mr 14,000) is restricted to the 1 region of the mouse MHC, while EPF-S2 (estimated Mr 55,000) is restricted to a locus (or loci) outside the MHC. Like other antigen non-specific factors, release of these suppressor factors can be stimulated also by Con A.
Rolfe
B E
BE
Department of Surgery, University of Queensland, Brisbane, Australia.
Cavanagh
A C
AC
Quinn
K A
KA
Morton
H
H
D000818:Animals; D018835:Chaperonin 10; D002850:Chromatography, Gel; D002874:Chromosome Mapping; D003877:Dermatitis, Contact / Q000276:immunology; D007116:Immunization, Passive; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D010455:Peptides / Q000494:pharmacology*; D011257:Pregnancy Proteins; D012397:Rosette Formation; D013154:Spleen / Q000276:immunology; D013491:Suppressor Factors, Immunologic / Q000096:biosynthesis* / Q000235:genetics
D018835:Chaperonin 10; D007166:Immunosuppressive Agents; D010455:Peptides; D011257:Pregnancy Proteins; D013491:Suppressor Factors, Immunologic; C025124:early pregnancy factor