title: [Characteristics of the immune response in children multiply inoculated with an inactivated influenza vaccine].
abstract: The observations involved 1082 children ranging in ages from 11 to 14 years who had been annually given from one to four injections of inactivated chromatographic influenza vaccine. An additional group consisted of 242 children who after three years of vaccination with the inactivated vaccine were given a live influenza vaccine type A (H1N1) and A (H3N2) for children. The studies showed that the highest immunological effect in children was achieved after two years of vaccination with the inactivated influenza vaccine. No positive effect on the immune response in children was demonstrated by the addition of a live vaccine into the immunization schedule against the background of multiple immunizations with the inactivated one. Different types of responses in children to immunization against influenza were observed.
authors.forename: L G
authors.initials: LG
authors.lastname: Rudenko
authors.forename: R I
authors.initials: RI
authors.lastname: Vasil'eva
authors.forename: L A
authors.initials: LA
authors.lastname: Smirnova
authors.forename: E M
authors.initials: EM
authors.lastname: Doroshenko
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D006801:Humans; D007117:Immunization, Secondary; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated
vernacular_title: Osobennosti immunnogo otveta u deteĭ, mnogokratno privitykh inaktivirovannoĭ grippoznoĭ vaktsinoĭ.