title: Coronary dilation with carotid chemoreceptor stimulation in cardiac-denervated dogs.
abstract: The coronary vasodilation that is secondary to carotid chemoreceptor stimulation (CCS) was compared in normal (N) and in cardiac-denervated (CD) conscious dogs. Under base-line conditions, CD only differed from N dogs by greater (P less than 0.01) increases in mean arterial pressure (MAP) with CCS. Coronary blood flow (CBF) increased similarly in N (146 +/- 18%) and CD (126 +/- 15%) dogs, and coronary resistance (CR) fell to a similar extent in N (53 +/- 3%) and CD (43 +/- 5%) dogs. After muscarinic and beta-adrenergic blockade, CCS resulted in similar increases in MAP in N and CD dogs; increases in CBF averaged 122 +/- 15 and 115 +/- 12% in N and CD dogs, respectively. Decreases in CR with CCS averaged 46 +/- 3 and 40 +/- 5% in N and CD dogs, respectively. alpha 1-Adrenergic blockade prevented the increases in MAP with CCS and resulted in smaller (P less than 0.01) increases in CBF, similar in N (77 +/- 13%) and in CD (69 +/- 10%) dogs. CR fell to the same extent in N (40 +/- 4%) and CD (37 +/- 5%) dogs. Additional blockade of alpha 2-adrenergic receptors further limited the increases in CBF with CCS in N (20 +/- 5%) and CD (28 +/- 7%) dogs; decreases in CR were attenuated similarly in N (13 +/- 5%) and CD (21 +/- 5%) dogs. Thus, in conscious dogs, cardiac nerves contribute little to the coronary dilation after carotid chemoreceptor stimulation.
authors.affiliation: Department of Physiology, Faculty of Medicine, Université de Montréal, Quebec, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Nagata
authors.forename: R
authors.initials: R
authors.lastname: Pichet
authors.forename: M
authors.initials: M
authors.lastname: Lavallee
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002346:Carotid Sinus / Q000502:physiology*; D002628:Chemoreceptor Cells / Q000502:physiology*; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000502:physiology*; D003714:Denervation; D004285:Dogs; D006321:Heart / Q000294:innervation*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012016:Reference Values; D012119:Respiration / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D014664:Vasodilation; D015016:Yohimbine / Q000494:pharmacology
chemical_list: D015016:Yohimbine; D001285:Atropine; D011433:Propranolol; D011224:Prazosin