title: [Endoscopic study of gastric tolerance of paracetamol and acetylsalicylic acid. A placebo-controlled double-blind study on healthy subjects].
abstract: Endoscopic Studies on the Gastric Tolerance of Paracetamol and Acetylsalicylic Acid/A placebo-controlled double-blind study in healthy volunteers. In placebo-controlled randomized double-blind cross-over fashion the gastric and duodenal tolerance of 1000 mg acetylsalicylic acid (ASA; as a commercially available preparation and 1000 mg paracetamol (Tylenol) were directly compared in 12 healthy volunteers. An endoscopic evaluation of the gastric and duodenal mucosa was performed. 1000 mg ASA evoked a lesion score of 2.5 whereas 1000 mg paracetamol and placebo displayed a score of 1.0 and 0.92, respectively. This difference between paracetamol and ASA reached a statistical significance. Based on the comparable analgetic potency of both compounds and the apparently better gastro-duodenal tolerability paracetamol is the drug of choice when a non-inflammatory problem requires an analgesic.
authors.affiliation: Gastroenterologischen Abteilung der Medizinischen Universitätsklinik Heidelberg.
authors.forename: P
authors.initials: P
authors.lastname: Müller
authors.forename: H G
authors.initials: HG
authors.lastname: Dammann
authors.forename: B
authors.initials: B
authors.lastname: Simon
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D004311:Double-Blind Method; D004386:Duodenum / Q000187:drug effects; D005773:Gastroscopy; D006801:Humans; D008297:Male; D011897:Random Allocation; D013276:Stomach Ulcer / Q000139:chemically induced*
chemical_list: D000082:Acetaminophen; D001241:Aspirin
vernacular_title: Endoskopische Untersuchungen zur Magenverträglichkeit von Paracetamol und Acetylsalicylsäure. Eine Plazebo-kontrollierte Doppelblindstudie an gesunden Probanden.