[Treatment of experimental trypanosomiasis caused by Trypanosoma brucei brucei in sheep: study of the minimum active dose of melarsoprol].
Trypanosoma brucei brucei experimentally infected sheep with central nervous system involvement were treated with melarsoprol (Arsobal, Specia, France). The purpose was to determine minimum efficiency concentrations of this drug. Eight sheep divided in four groups of two animals were treated intravenously for 3 days with the following respective dosages: 1.8, 0.9, 0.45 and 0.225 mg/kg/d. After a year of observation, efficient dosages were 1.8 and 0.9 mg/kg/d. The experimentation suggests the possibility to reduce usually given dosages in man.
Bouteille
B
B
Service de Parasitologie-Mycologie, C.H.U. Dupuytren, Limoges.
Darde
M L
ML
Pestre-Alexandre
M
M
Dumas
M
M
Breton
J C
JC
Nicolas
J A
JA
Catanzano
G
G
Munoz
M
M
D000818:Animals; D001152:Arsenicals / Q000008:administration & dosage*; D007275:Injections, Intravenous; D008549:Melarsoprol / Q000008:administration & dosage* / Q000627:therapeutic use; D012756:Sheep; D014346:Trypanosoma brucei brucei; D014353:Trypanosomiasis, African / Q000188:drug therapy*
D001152:Arsenicals; D008549:Melarsoprol
Traitement de la trypanosomiase expérimentale du mouton à Trypanosoma brucei brucei: recherche d'une dose minima active de mélarsoprol.