title: S-100b protein regulates the activity of skeletal muscle adenylate cyclase in vitro.
abstract: We have investigated the effect of the b isoform of S-100 proteins on adenylate cyclase activity of rat skeletal muscle. S-100b inhibits the adenylate cyclase activity in the presence of Mg2+ (5.0-50 mM), while it activates the same enzyme in the presence of Ca2+ (0.1-1.0 mM) dose-dependently in both cases. S-100b counteracts the stimulatory effect of NaF on adenylate cyclase in the presence of Mg2+ and the inhibitory effect of RMI 12330 A in the presence of Ca2+.
authors.affiliation: Istituto di Biologia Cellulare, Università di Perugia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Fanò
authors.forename: S
authors.initials: S
authors.lastname: Fulle
authors.forename: G
authors.initials: G
authors.lastname: Della Torre
authors.forename: I
authors.initials: I
authors.lastname: Giambanco
authors.forename: M C
authors.initials: MC
authors.lastname: Aisa
authors.forename: R
authors.initials: R
authors.lastname: Donato
authors.forename: P
authors.initials: P
authors.lastname: Calissano
mesh_terms: D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000502:physiology; D004789:Enzyme Activation; D007097:Imines / Q000494:pharmacology; D008274:Magnesium / Q000502:physiology; D009132:Muscles / Q000201:enzymology*; D051381:Rats; D009418:S100 Proteins / Q000502:physiology*; D012969:Sodium Fluoride / Q000494:pharmacology
chemical_list: D000067956:Adenylyl Cyclase Inhibitors; D007097:Imines; D009418:S100 Proteins; C014925:RMI 12330A; D012969:Sodium Fluoride; D000262:Adenylyl Cyclases; D008274:Magnesium; D002118:Calcium