Cancers of the respiratory tract in mustard gas workers.
In a study of a cohort of 2498 men and 1032 women employed in the manufacture of mustard gas in Cheshire during the second world war 3354 (95%) individuals were successfully traced for mortality to the end of 1984. Large and highly significant excesses were observed as compared with national death rates for deaths from cancer of the larynx (11 deaths observed, 4.04 expected, p = 0.003), pharynx (15 observed, 2.73 expected, p less than 0.001), and all other buccal cavity and upper respiratory sites combined (lip, tongue, salivary gland, mouth, nose) (12 observed, 4.29 expected, p = 0.002). For lung cancer, a highly significant but more moderate excess was observed (200 observed, 138.39 expected, p less than 0.001). Significant excesses were also observed for deaths from acute and chronic non-malignant respiratory disease (131 observed, 91.87 expected and 185 observed, 116.31 expected, respectively). The risks for cancers of the pharynx and lung were significantly related to duration of employment. None of these results is substantially altered when expected numbers are calculated from Cheshire urban areas rather than national rates, although the relative risks for lung cancer and non-malignant respiratory disease are substantially reduced if rates for Merseyside, the nearest large conurbation, are used. The results provide strong evidence that exposure to mustard gas can cause cancers of the upper respiratory tract and some evidence that it can cause lung cancer and non-malignant respiratory disease.(ABSTRACT TRUNCATED AT 250 WORDS)
Easton
D F
DF
Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK.
Peto
J
J
Doll
R
R
D015331:Cohort Studies; D004739:England; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009150:Mustard Compounds / Q000633:toxicity*; D009151:Mustard Gas / Q000633:toxicity*; D009784:Occupational Diseases / Q000139:chemically induced / Q000401:mortality*; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced / Q000401:mortality*; D012307:Risk Factors; D013997:Time Factors
D009150:Mustard Compounds; D009151:Mustard Gas