[Effects of opioid peptide dalargin on reparative processes in wound healing].
At intraperitoneal injection and local application of opioid peptide dalargin induces fibroblast proliferation (3-fold increase in the mitotic index) and growth of capillaries, accelerates the maturation of granulation tissue and of scar, epitheliazation of the defect, and considerably reduces the period of healing of skin wound in rats. The stimulating action of dalargin is associated with its effect on the microcirculation system and activation of the macrophage-fibroblast interaction. Possessing the triggering mechanism, the drug induces a cascade of inflammatory-reparative reactions, which reduce the duration of all healing stages.
Shekhter
A B
AB
Solov'eva
A I
AI
Spevak
S E
SE
Titov
M I
MI
D000287:Administration, Topical; D000818:Animals; D004743:Enkephalin, Leucine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D005347:Fibroblasts; D006097:Granulation Tissue / Q000166:cytology; D007274:Injections, Intraperitoneal; D008264:Macrophages / Q000166:cytology; D008297:Male; D008940:Mitotic Index; D051381:Rats; D012867:Skin / Q000293:injuries; D014945:Wound Healing / Q000187:drug effects*
D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie opiopeptida dalargina na reparativnye protsessy pri zashivlenii ran.