title: Adrenal pheochromocytoma-ganglioneuroma producing catecholamines and various neuropeptides.
abstract: A 65-year-old woman presenting with back pain, difficulties in walking and watery diarrhea. A right adrenal tumor and high excretion of catecholamines were found. Laboratory examinations showed raised levels of vasoactive intestinal polypeptide, pancreatic polypeptide, gastrin and calcitonin. Histology showed a combined pheochromocytoma-ganglioneuroma. The neoplastic cell population was immunohistochemically shown to contain tyrosine hydroxylase, neuropeptide Y, met-enkephalin, substance P, vasoactive intestinal polypeptide, calcitonin and calcitonin gene-related peptide. Postoperatively, the patient recovered fully and the hormone levels returned to normal.
authors.affiliation: Department of Internal Medicine, University Central Hospital of Tampere, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Salmi
authors.forename: M
authors.initials: M
authors.lastname: Pelto-Huikko
authors.forename: O
authors.initials: O
authors.lastname: Auvinen
authors.forename: A L
authors.initials: AL
authors.lastname: Karvonen
authors.forename: J
authors.initials: J
authors.lastname: Saaristo
authors.forename: I
authors.initials: I
authors.lastname: Paronen
authors.forename: L
authors.initials: L
authors.lastname: Pöyhönen
authors.forename: S
authors.initials: S
authors.lastname: Seppänen
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000368:Aged; D002395:Catecholamines / Q000378:metabolism*; D005260:Female; D005729:Ganglioneuroma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D006801:Humans; D009479:Neuropeptides / Q000378:metabolism*; D010673:Pheochromocytoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery
chemical_list: D002395:Catecholamines; D009479:Neuropeptides