Aviation gasoline: comparative subchronic nephrotoxicity study in the male rat.
Biochemical and histopathologic parameters of nephrotoxicity were measured in groups of male Fischer-344 rats after a 2-week, 5-days-a-week schedule of oral administration (0.5 ml/kg) of the following substances: aviation gasoline (grade 100) (AVG), automobile regular unleaded gasoline (ULG) and 2,2,4-trimethylpentane (TMP). Results of renal histopathologic examinations and biochemical parameters were compatible with the following order of increasing nephrotoxicity: ULG less than TMP less than AVG. The high nephrotoxic potential of aviation gasoline may be related to its elevated content in branched hydrocarbons.
Gérin
M
M
Département de médecine du travail et d'hygiène du milieu, Université de Montréal, Québec, Canada.
Viau
C
C
Talbot
D
D
Greselin
E
E
D000118:Acetylglucosaminidase / Q000652:urine; D000284:Administration, Oral; D000818:Animals; D001806:Blood Urea Nitrogen; D005742:Gasoline / Q000633:toxicity*; D006029:Glycosuria / Q000139:chemically induced; D007674:Kidney Diseases / Q000139:chemically induced*; D007770:L-Lactate Dehydrogenase / Q000652:urine; D008297:Male; D009795:Octanes / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D010578:Petroleum / Q000633:toxicity*; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D011916:Rats, Inbred F344
D005742:Gasoline; D009795:Octanes; D010578:Petroleum; D007770:L-Lactate Dehydrogenase; D000118:Acetylglucosaminidase; C045798:2,2,4-trimethylpentane