Expression of estramustine-binding protein (EMBP) and the proliferation-associated antigen Ki-67 in prostatic carcinomas.
The expression of EMBP and the proliferation-associated antigen Ki-67 was studied in in vitro cultured prostatic carcinoma cells and in tumor tissues removed by transurethral electroresection (TUR). EMBP was found to be expressed predominantly in the moderately differentiated carcinomas. A technique based on the immunohistochemical analysis of fine needle specimens was also evaluated. This technique is of potential interest in prospective studies and in monitoring the effect of therapy. Ki-67 was found to be expressed in the prostatic carcinoma cell line (DU-145) studied, as well as in TUR specimens. This antigen reflects the proliferative characteristics of the tumor and may prove useful with respect to prognostic information and choice of appropriate therapy.
Nilsson
S
S
Department of Oncology, University of Uppsala, Sweden.
Nordgren
H
H
Karlberg
L
L
Harvig
B
B
Busch
C
C
Hall
T
T
Björk
P
P
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000378:metabolism*; D001324:Autoantigens / Q000378:metabolism*; D001706:Biopsy; D002352:Carrier Proteins / Q000378:metabolism*; D002460:Cell Line; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism*; D029584:Prostatic Secretory Proteins; D014407:Tumor Cells, Cultured / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D001324:Autoantigens; D002352:Carrier Proteins; D019394:Ki-67 Antigen; D029584:Prostatic Secretory Proteins; C028321:estramustine-binding protein