Synthesis and antibacterial activity of N-acyl vancomycins.
Several glycopeptides containing N-acyl groups have been isolated recently. We undertook the synthesis of N-acyl vancomycins, using the active ester method. The in vitro and in vivo antibacterial activity were evaluated, and structure-activity relationship of this series of semisynthetic vancomycins is discussed.
Nagarajan
R
R
Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285.
Schabel
A A
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Occolowitz
J L
JL
Counter
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Ott
J L
JL
D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D051379:Mice; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D014640:Vancomycin