title: Farm animal feeders: another group affected by cereal flour asthma.
abstract: Asthma induced by cereal flour is a long recognized entity. We present studies of three patients affected by asthma related to exposure to cereal flour contained in animal formula feeds. Skin prick test performed with the formula feed components showed positive reactions to cereal flours (wheat, rye and barley) and negative to the other substances in these formulas. Specific anti-wheat, rye and barley flour IgE antibodies were found by RAST. Bronchial provocation tests (BPT) with wheat flour (patients 1 and 2) and barley flour (patient 3) all showed immediate responses. These findings suggest that our patients' symptoms were caused by an IgE-mediated hypersensitivity to cereal flours from animal formula feeds. We call attention to the importance of cereal flours in animal formula feeds as a cause of occupational asthma in farm and animal feeders.
authors.affiliation: Department of Allergy, Hospital Ramon y Cajal, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Valdivieso
authors.forename: J
authors.initials: J
authors.lastname: Pola
authors.forename: C
authors.initials: C
authors.lastname: Zapata
authors.forename: J
authors.initials: J
authors.lastname: Puyana
authors.forename: J
authors.initials: J
authors.lastname: Cuesta
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.forename: E
authors.initials: E
authors.lastname: Losada
mesh_terms: D000293:Adolescent; D000328:Adult; D000382:Agricultural Workers' Diseases / Q000209:etiology*; D000821:Animal Feed / Q000009:adverse effects*; D001249:Asthma / Q000209:etiology*; D001985:Bronchial Provocation Tests / Q000379:methods; D002523:Edible Grain / Q000009:adverse effects* / Q000276:immunology; D005433:Flour / Q000009:adverse effects*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012882:Skin Tests / Q000379:methods
chemical_list: D007073:Immunoglobulin E