Incidence of hydronephrosis among several production colonies of outbred Sprague-Dawley rats.
The incidence of hydronephrosis was determined in nine production colonies of Crl:CD (SD) BR rats (CD rats). Kidneys from 3909 rats were examined and 79 (2.0%) had unilateral or bilateral hydronephrosis. A colony with a relatively high incidence of hydronephrosis (4.1%) was chosen for further study. In unselected rats from this colony the incidence in females (87/1882, 4.6%) was not significantly different from that in males (79/1862, 4.2%). In the same group of rats, hydronephrosis was observed most frequently in the right kidney only (2.3%), followed by bilateral involvement (1.2%) and the left kidney only (0.8%). By selection and inbreeding, the incidence of hydronephrosis was increased dramatically (to 33.6%) in two generations. Hydronephrosis in the CD rat appears to be a highly heritable trait, most likely involving more than one gene.
Van Winkle
T J
TJ
Charles River Professional Services, Wilmington, MA 01887.
Womack
J E
JE
Barbo
W D
WD
Davis
T W
TW
D000818:Animals; D000830:Animals, Laboratory; D001947:Breeding; D005260:Female; D006869:Hydronephrosis / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000453:epidemiology* / Q000235:genetics