title: Influence of indomethacin on PGE2 in rabbit aqueous humor after YAG laser photodisruption of the iris.
abstract: In an experimental study with rabbits, the influence of indomethacin on the postoperative PGE2 level in the aqueous humor was investigated, following YAG laser traumatization of the iris. Indomethacin is a drug with an inhibitory effect on the synthesis of prostaglandins. Using albino rabbits, the right eye was treated with indomethacin eye drops three times daily for 3 days. On the 4th day, high-energy YAG laser was applied to the iris of both eyes (Q-switched Nd: YAG Laser, Model Cilco Lasertek PV 135; ten photodisruptive lesions, with 50 mJ to the midperiphery of the iris). Subsequently, the rabbits were subdivided into three groups. In group 1 the aqueous humor was removed from both eyes 12 h postoperatively; in group 2 the aqueous humor was tapped 36 h after the intervention; for group 3, it was 60 h afterwards. The results from 15 rabbits were evaluated. Local indomethacin treatment was continued until tapping of the aqueous humor. As a control, another group was used with 3 rabbits without treatment. Twelve hours after YAG laser treatment there was still a clearly significant difference in the PGE2 concentrations between the eyes that had received indomethacin and the untreated eyes; 36 h postoperatively, the difference was no longer statistically significant, and after 60 h the PGE2 concentrations of the treated and untreated eyes were the same.
authors.affiliation: Universitäts-Augenklinik, Wien, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Skorpik
authors.forename: M
authors.initials: M
authors.lastname: Juchem
authors.forename: P
authors.initials: P
authors.lastname: Paroussis
authors.forename: H
authors.initials: H
authors.lastname: Vierhapper
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D007498:Iris / Q000528:radiation effects*; D007834:Lasers; D008297:Male; D009994:Osmolar Concentration; D011817:Rabbits; D013997:Time Factors
chemical_list: D015232:Dinoprostone; D007213:Indomethacin