title: The structure of the human glutathione S-transferase pi gene.
abstract: The human glutathione S-transferase pi gene has been isolated from a cosmid library. The gene spans approximately 3 kb, is interrupted by six introns and the region around its 5' end has the high G + C and CpG content typical of an HTF (HpaII tiny fragment) island. In addition to a TATA box at position -28 relative to the transcription initiation site and two G + C boxes (GGGCGG), the promoter contains a sequence motif matching the phorbol ester- and ras-responsive element from the polyoma virus enhancer.
authors.affiliation: Cancer Research Campaign Molecular Toxicology Research Group, University College and Middlesex School of Medicine, London, U.K.
authors.forename: I G
authors.initials: IG
authors.lastname: Cowell
authors.forename: K H
authors.initials: KH
authors.lastname: Dixon
authors.forename: S E
authors.initials: SE
authors.lastname: Pemble
authors.forename: B
authors.initials: B
authors.lastname: Ketterer
authors.forename: J B
authors.initials: JB
authors.lastname: Taylor
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D015139:Blotting, Southern; D003001:Cloning, Molecular; D005796:Genes; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
chemical_list: D007527:Isoenzymes; D005982:Glutathione Transferase