title: Interferon-beta induced remission in a hairy cell leukemia patient resistant to interferon-alpha.
abstract: Two patients with advanced hairy cell leukemia and pancytopenia responded successfully to intramuscular injections of recombinant interferon-beta, with normalisation of blood counts. One of the patients had developed resistance to interferon-alpha. The in-vivo response was predicted by in-vitro studies showing a beneficial effect of IFN-beta on erythropoiesis in cell cultures derived from these patients.
authors.affiliation: Institute of Hematology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Rehovot, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Michalevicz
authors.forename: D
authors.initials: D
authors.lastname: Aderka
authors.forename: B
authors.initials: B
authors.lastname: Frisch
authors.forename: M
authors.initials: M
authors.lastname: Revel
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D004351:Drug Resistance; D004920:Erythropoiesis / Q000187:drug effects; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology / Q000627:therapeutic use*; D007943:Leukemia, Hairy Cell / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D012074:Remission Induction; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014410:Tumor Stem Cell Assay
chemical_list: D007370:Interferon Type I; D011994:Recombinant Proteins