[Radioprotective activity of complexes of copper, cobalt and zinc with substituted acylhydrazones].
Acylhydrazone metal complexes belong to a new class of radioprotective agents that have a cytostatic effect increasing, in some cases, the survival rate of irradiated animals by 40-60 per cent compared to irradiated controls. The most active drugs are hypotoxic and applied in much lower doses than ordinary S-containing radioprotective agents to achieve the same protective effect.
Arapov
O V
OV
Arestova
L S
LS
Alferova
O F
OF
Krasil'nikov
I I
II
Khorseeva
L A
LA
D000818:Animals; D003035:Cobalt / Q000627:therapeutic use / Q000633:toxicity; D003300:Copper / Q000627:therapeutic use / Q000633:toxicity; D006835:Hydrazones / Q000627:therapeutic use* / Q000633:toxicity; D008670:Metals / Q000627:therapeutic use* / Q000633:toxicity; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use* / Q000633:toxicity; D015032:Zinc / Q000627:therapeutic use / Q000633:toxicity
D006835:Hydrazones; D008670:Metals; D011837:Radiation-Protective Agents; D003035:Cobalt; D003300:Copper; D015032:Zinc
Radiozashchitnaia aktivnost' kompleksov medi, kobal'ta i tsinka s zameshchennymi atsilgidrazonami.