title: Activity of porphobilinogen deaminase in peripheral blood mononuclear cells of patients with metastatic cancer.
abstract: Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral mononuclear cells of 60% of patients with epithelial tumors and metastatic spread, but only in 14% of patients with tumor and no evidence of metastases. The combination of both high lactic dehydrogenase and high PBGD afforded a sensitivity of 40%, but a specificity of 96% in diagnosing metastatic spread.
authors.affiliation: Department of Internal Medicine B, Beilinson Medical Center, Petah Tiqva, Israel.
authors.forename: L
authors.initials: L
authors.lastname: Leibovici
authors.forename: N
authors.initials: N
authors.lastname: Schoenfeld
authors.forename: H A
authors.initials: HA
authors.lastname: Yehoshua
authors.forename: R
authors.initials: R
authors.lastname: Mamet
authors.forename: E
authors.initials: E
authors.lastname: Rakowsky
authors.forename: A
authors.initials: A
authors.lastname: Shindel
authors.forename: A
authors.initials: A
authors.lastname: Atsmon
mesh_terms: D000328:Adult; D000368:Aged; D000642:Ammonia-Lyases / Q000097:blood*; D001943:Breast Neoplasms / Q000201:enzymology; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000201:enzymology; D006801:Humans; D011163:Hydroxymethylbilane Synthase / Q000097:blood*; D007963:Leukocytes, Mononuclear / Q000201:enzymology*; D008175:Lung Neoplasms / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000201:enzymology*; D010051:Ovarian Neoplasms / Q000201:enzymology
chemical_list: D011163:Hydroxymethylbilane Synthase; D000642:Ammonia-Lyases