title: Identification and analysis of a degradation product of the glucocorticoid desonide in ointment.
abstract: The major degradation product of desonide in a pharmaceutical ointment formulation has been shown to be identical with the C-17-carboxylic acid obtained on oxidative cleavage of the alpha-ketol group of desonide with alkaline hydrogen peroxide. The pKa value of this acid has been estimated from chromatographic data.
authors.affiliation: Pharmaceutical Quality Assurance, Apothekernes Laboratorium A.S., Oslo, Norway.
authors.forename: T T
authors.initials: TT
authors.lastname: Nguyen
authors.forename: R
authors.initials: R
authors.lastname: Kringstad
authors.forename: A J
authors.initials: AJ
authors.lastname: Aasen
authors.forename: K E
authors.initials: KE
authors.lastname: Rasmussen
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003898:Desonide / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D009824:Ointments; D011246:Pregnadienetriols / Q000032:analysis*
chemical_list: D009824:Ointments; D011246:Pregnadienetriols; D003898:Desonide