Do contrast media aggravate Fanconi's syndrome in rats? A comparison of diatrizoate, iohexol, and ioxilan.
Urine profiles (albumin, glucose, N-acetyl-beta-D-glucosaminidase [NAG], lactate dehydrogenase [LDH], L-gamma-glutamyltransferase [GGT], sodium, and phosphate) were followed for seven days after intravenous (IV) administration of either diatrizoate, iohexol, ioxilan, or saline in 24 Wistar rats with a tubular dysfunction induced by IV sodium maleate. Ioxilan and saline had a similar effect on albumin excretion, iohexol had an intermediate effect, and diatrizoate increased it significantly from day 2 to day 7. Glucosuria was significantly greater after diatrizoate than after the nonionic contrast media (CM) or saline. Diatrizoate delayed normalization of enzymuria, whereas iohexol and ioxilan did not. None of the CM affected urinary sodium or phosphate excretion. It is concluded that Fanconi's syndrome is significantly aggravated only by diatrizoate.
Thomsen
H S
HS
Department of Diagnostic Radiology, Herlev Hospital, University of Copenhagen, Denmark.
Dorph
S
S
Mygind
T
T
Nielsen
H
H
Rygaard
H
H
Larsen
S
S
Skaarup
P
P
Hemmingsen
L
L
Holm
J
J
D000818:Animals; D003287:Contrast Media / Q000633:toxicity*; D003973:Diatrizoate / Q000633:toxicity*; D005198:Fanconi Syndrome / Q000139:chemically induced*; D007472:Iohexol / Q000031:analogs & derivatives* / Q000633:toxicity*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003287:Contrast Media; D003973:Diatrizoate; D007472:Iohexol; C055357:ioxilan