title: [ADP-ribosylation of nuclear proteins in the rat brain].
abstract: The distribution of (ADP-ribose)n synthesized from [14C]NAD labeled at the adenyl ring in several protein fractions of isolated rat brain nuclei was studied. Preferential ADP-ribosylation of nonhistone nuclear proteins was shown to occur. It was demonstrated that pol (ADP-ribose)polymerase and DNA-topoisomerase II are located spatially close to each other. A correlation between ADP-ribosylation and the activity of nuclear matrix DNA-topoisomerase II was established.
authors.forename: T M
authors.initials: TM
authors.lastname: Zaalishvili
authors.forename: K M
authors.initials: KM
authors.lastname: Kolkhidashvili
authors.forename: D O
authors.initials: DO
authors.lastname: Margiani
authors.forename: R D
authors.initials: RD
authors.lastname: Michilashvili
mesh_terms: D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D002467:Cell Nucleus / Q000201:enzymology / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004278:DNA, Superhelical / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D009243:NAD / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D051381:Rats
chemical_list: D004278:DNA, Superhelical; D009687:Nuclear Proteins; D009243:NAD; D000246:Adenosine Diphosphate Ribose; D004247:DNA
vernacular_title: ADP-ribozilirovanie iadernykh belkov golovnogo mozga krys.