title: A retrospective study of antibodies against basement membrane antigens (type IV collagen and laminin) in patients with primary and secondary Raynaud's phenomenon.
abstract: Antibodies against type IV collagen were detected in the sera of 21% of patients with primary Raynaud's phenomenon (PRP) and 68% of patients with systemic sclerosis. Sera from 25% of the PRP patients and 48% of systemic sclerosis patients displayed antibodies to laminin. Eighty percent of the patients with PRP and antibodies to basement membrane antigens developed additional serologic or clinical manifestations, whereas only 16% of patients with PRP and no anti-basement membrane antibodies developed such manifestations.
authors.affiliation: Istituto di Patologia Speciale Medica, Universitá degli Studi di Ancona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Gabrielli
authors.forename: M
authors.initials: M
authors.lastname: Montroni
authors.forename: S
authors.initials: S
authors.lastname: Rupoli
authors.forename: M L
authors.initials: ML
authors.lastname: Caniglia
authors.forename: F
authors.initials: F
authors.lastname: DeLustro
authors.forename: G
authors.initials: G
authors.lastname: Danieli
mesh_terms: D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000032:analysis / Q000276:immunology*; D001485:Basement Membrane / Q000276:immunology*; D003094:Collagen / Q000145:classification / Q000276:immunology*; D003240:Connective Tissue Diseases / Q000150:complications / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007797:Laminin / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011928:Raynaud Disease / Q000150:complications / Q000276:immunology*; D012016:Reference Values; D012189:Retrospective Studies
chemical_list: D000906:Antibodies; D007797:Laminin; D003094:Collagen