title: Maternal transmission and dental caries induction in Sprague-Dawley rats infected with Streptococcus mutans.
abstract: Thirty-four female rats (18 days old) were infected with Streptococcus mutans MT8148R (serotype c) or 6715 (g). Diets containing different proportions of sucrose were used to prepare the dams which harbored various levels of S. mutans in their oral cavity. Around 66 days of age, the female rats were bred and 34 dams subsequently bore 322 offspring. The dams were killed upon weaning (20 days of age) of their respective litters. There were positive correlations between the recovery of inoculated S. mutans and the caries incidence in the dams. Transmission of S. mutans from a dam to her offspring was studied in 10-, 15-, 20-, 27-, 34-, 41-, 48-, and 55-day-old rats by evaluating the recover of S. mutans from the offspring. Positive correlation between the magnitudes of recovered S. mutans MT8148R from dams and their offspring was found in all ages of young rats examined. Furthermore, caries incidence in young rats was found to be positively correlated with the recovery of both strains of S. mutans as well as with incidence of caries in their respective dams.
authors.affiliation: Department of Pedodontics, Osaka University Faculty of Dentistry.
authors.forename: T
authors.initials: T
authors.lastname: Ooshima
authors.forename: N
authors.initials: N
authors.lastname: Sumi
authors.forename: A
authors.initials: A
authors.lastname: Izumitani
authors.forename: S
authors.initials: S
authors.lastname: Sobue
mesh_terms: D000818:Animals; D003731:Dental Caries / Q000635:transmission*; D004195:Disease Models, Animal; D005260:Female; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013290:Streptococcal Infections / Q000635:transmission*; D013295:Streptococcus mutans / Q000302:isolation & purification