[Modulation of the M-cholinergic reaction by the venom of the Central Asian cobra (Naja naja oxiana)].
The effect of the Central Asian cobra's (Naja naja oxiana) poison upon cholinergic response of isolated small intestine was studied in the Wistar rats. The effect involved a significant activation by 30-70 per cent of M-cholinergic response in the type of "noncompetitive" interaction. The modulating effect of the poison is supposed to occur due to changes in cytoplasmatic membrane.
Kichikulova
T P
TP
Berdyeva
A T
AT
Manukhin
B N
BN
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004546:Elapid Venoms / Q000494:pharmacology*; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000187:drug effects*
D004546:Elapid Venoms; D011976:Receptors, Muscarinic; D000109:Acetylcholine
Moduliatsiia M-kholinergicheskoĭ reaktsii iadom sredneaziatskoĭ kobry.