Specific binding sites of muroctasin on murine macrophages.
The specific binding sites for N2-[N-acetylmuramoyl)-L-alanyl-D-isoglutaminyl]-N6-stearoyl-L-lysine (MDP-Lys(L18), muroctasin), a synthetic muramyl dipeptide analog, on murine macrophages were investigated using [3H]-MDP-Lys(L18). The specific binding sites were found to be located on macrophage membrane and not to cross-react with MDP. It was also found that MDP-Lys(L18) was not metabolized by macrophages.
Akasaki
M
M
Research Institute, Daiichi Seiyaku Co., Ltd., Tokyo, Japan.
Masayasu
H
H
Tsukada
W
W
Takegoshi
T
T
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000378:metabolism; D000276:Adjuvants, Immunologic / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D002855:Chromatography, Thin Layer; D003429:Cross Reactions; D005260:Female; D008264:Macrophages / Q000378:metabolism*; D051379:Mice
D000276:Adjuvants, Immunologic; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C036866:romurtide