title: Synthesis and antibacterial activity of N-acyl vancomycins.
abstract: Several glycopeptides containing N-acyl groups have been isolated recently. We undertook the synthesis of N-acyl vancomycins, using the active ester method. The in vitro and in vivo antibacterial activity were evaluated, and structure-activity relationship of this series of semisynthetic vancomycins is discussed.
authors.affiliation: Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285.
authors.forename: R
authors.initials: R
authors.lastname: Nagarajan
authors.forename: A A
authors.initials: AA
authors.lastname: Schabel
authors.forename: J L
authors.initials: JL
authors.lastname: Occolowitz
authors.forename: F T
authors.initials: FT
authors.lastname: Counter
authors.forename: J L
authors.initials: JL
authors.lastname: Ott
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D051379:Mice; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis
chemical_list: D014640:Vancomycin