[Dose-related effect of nicainoprol (CAS 924) on basic electrophysiologic parameters in patients with and without diseases of the heart conduction system].
The dose-dependent effects of nicainoprol (1 and 2 mg/kg/h), a new antiarrhythmic drug, on invasive electrophysiological parameters were evaluated in 28 patients during diagnostic electrophysiologic studies. The most pronounced effects by nicainoprol were observed on the specialized AV conduction system. The intranodal (1 mg/kg/h: A-H interval: 92 +/- 19 ms to 107 +/- 25 ms, p less than 0.002, n = 13; 2 mg/kg/h: 92 +/- 18 ms to 114 +/- 27 ms, p less than 0.001, n = 16) and, in particular, the infranodal conduction time (1 mg/kg/h: H-V interval: 45 +/- 5 ms to 52 +/- 9 ms, p less than 0.001, n = 15; 2 mg/kg/h: 45 +/- 6 ms to 58 +/- 10 ms, p less than 0.0001, n = 18) were delayed in a dose-dependent fashion. With the higher dose, there was a highly significant prolongation of the AV nodal Wenckebach cycle length (380 +/- 69 ms to 440 +/- 79 ms, p less than 0.0001, n = 13) as well as of the effective (368 +/- 112 ms to 428 +/- 108 ms, p less than 0.001, n = 12) and functional refractory periods (470 +/- 102 ms to 521 +/- 135 ms, p less than 0.001, n = 15). The intraatrial conduction time was slightly prolonged for both doses, the intraventricular conduction time increased significantly with the higher dose (89 +/- 12 ms to 102 +/- 19 ms, p less than 0.001, n = 19). In contrast, there were only small changes of right atrial and right ventricular refractorion.(ABSTRACT TRUNCATED AT 250 WORDS)
Sen
S
S
Medizinische Universitäts- und Poliklinik Homburg/Saar, Innere Medizin III.
Rettig
G
G
Schieffer
H
H
Bette
L
L
D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001283:Atrioventricular Node / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000627:therapeutic use*; D012849:Sinoatrial Node / Q000187:drug effects
D000889:Anti-Arrhythmia Agents; D011412:Propanolamines; C047768:nicainoprol
Dosisabhängige Wirkung von Nicainoprol (CAS 924) auf die elektrophysiologischen Basisparameter bei Patienten mit und ohne Erkrankung des Reizleitungssystems.