Na+/H+ ion-exchange property of postmortem human gastric mucus.
The Na+/H+ ion-exchange property of human gastric mucus and its relationship to age has been studied. Mucus was collected from 40 postmortem human stomachs (age range, 21-83 years) within 24 h of traumatic death. Twenty-one stomachs (age range, 21-76 years) were free of Campylobacter pylori infection and histologic gastritis. Mucus from these stomachs was consistently a cation exchanger at pH 6 in an in vitro system. The cation-exchange capacity of mucus from seven stomachs within the age range 55-70 years was 50% less than the cation-exchange capacity of mucus from eight stomachs within the age range 20-35 years. This study shows that human gastric mucus at pH 6 is a cation exchanger and that the ion-exchange capacity decreases with age.
Thomsen
L
L
Dept. of Medicine, University of Auckland Medical School, New Zealand.
Tasman-Jones
C
C
Maher
K
K
Wiggins
P
P
Lee
S
S
Morris
A
A
D000328:Adult; D000367:Age Factors; D000368:Aged; D005753:Gastric Mucosa / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007474:Ion Exchange; D008875:Middle Aged; D012964:Sodium / Q000502:physiology
D012964:Sodium