Incidence and prognostic significance of autoantibodies against erythrocytes and platelets in chronic lymphocytic leukemia (CLL).
Antiglobulin Test (AT), and Dixon Tests (DT) have been studied in 100 patients with CLL. Thirty-five patients were Rai stage 0 and I, 19 patients stage 2, 13 patients stage 3 and 33 patients stage 4. Twelve patients showed a Red Blood Cells Autoantibodies (RBCAb) positivity; a positivity (direct, indirect, or both) of DT was present in 74% of patients. The presence of autoantibodies against erythrocytes and platelets did not influence survival curves, but anemia and thrombocytopenia are risk factors for survival, independently of the presence of an autoimmune disorder. Nine patients RBCAb positive and DT positive showed the worst survival curve, five out of these were anemic and one thrombocytopenic and anemic.
De Rossi
G
G
Human Biopathology Dept, University La Sapienza, Rome.
Granati
L
L
Girelli
G
G
Gandolfo
G
G
Arista
M C
MC
Martelli
M
M
Conti
L
L
Marini
R
R
La Tagliata
R
R
Leone
R
R
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000209:etiology; D001323:Autoantibodies / Q000032:analysis*; D001789:Blood Group Antigens / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology*; D003298:Coombs Test; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology
D001323:Autoantibodies; D001789:Blood Group Antigens; D007074:Immunoglobulin G