A compact and inexpensive device using an electronic calculator for measuring ambulatory activity in mice.
A device for measuring ambulatory activity in mice was developed. The device consisted of a plastic case, a bed plate, a step board (as a detector) and a calculator (as a recorder). A 2.2 cm width section was cut out from the middle of the case bottom in the direction of the minor axis and a step board, a width of 2 cm, was placed in the opening. A short bolt was screwed into one end of the step board and the head of the bolt was placed on the equal key of the calculator. The calculator counted the number of times the mouse stood on the step board. The validity of the device was demonstrated by measuring the effect of methamphetamine (1-4 mg/kg) on the ambulatory activity in mice.
Masuda
Y
Y
Department of Pharmacology, School of Dentistry, Iwate Medical University, Morioka, Japan.
Murai
S
S
Saito
H
H
Murakami
H
H
Itoh
T
T
D000818:Animals; D003201:Computers; D004305:Dose-Response Relationship, Drug; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*
D008694:Methamphetamine