Persistent dose-dependent increases in cycling of haemopoietic precursor cells after irradiation.
Between 3 weeks and 36 months after irradiation of mice, there was a dose-dependent increased level of cycling in haemopoietic stem cells (CFU-S) and in granulocyte-macrophage precursor cells (GM-CFC). For CFU-S the percentage kill measured using the thymidine suicide technique increased from about 10% in controls to a high and persistent average level of about 45% after 10 Gy gamma-rays, and for GM-CFC the increase was from about 30% to about 50%.
Tejero
C
C
Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital & Holt Radium Institute, Manchester, U.K.
Hendry
J H
JH
Testa
N G
NG
D000818:Animals; D003114:Colony-Forming Units Assay; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006098:Granulocytes / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000528:radiation effects*; D008264:Macrophages / Q000166:cytology; D051379:Mice; D013154:Spleen / Q000166:cytology