[Effect of hyperthermia and ionizing radiation separately or in combination on tumor metastasis].
The paper is devoted to a study of the effect of hyperthermia and irradiation used alone or in combination on the frequency and intensity of metastasizing of Walker carcinoma in rats, sarcoma-37 and 2 types (LLC and LLC-1) of Lewis lung carcinoma in mice. The frequency and intensity of metastasis depend not only on tumor type but also on a transplantation site. Metastasizing of tumor cells transplanted under the leg skin, occurs after a tumor reaches the volume of 25 mm3. Local hyperthermia (40-45 degrees C) and irradiation used alone or in combination, do not change the frequency and intensity of metastasis. However if a rise of body temperature is noted in local hyperthermia, larger tumor nodes appear in the lungs without evidence of an increase in the number of metastases.
Kurpeshev
O K
OK
D000818:Animals; D003131:Combined Modality Therapy; D006979:Hyperthermia, Induced; D051379:Mice; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D011859:Radiography; D051381:Rats; D011919:Rats, Inbred Strains
Vliianie razdel'nogo ili sochetannogo deĭstviia gipertermii i ioniziruiushchego izlucheniia na metastazirovanie opukholeĭ.