title: [Clinical experiences with intracervical prostaglandin E2 administration for labor induction].
abstract: From January 1, 1986 to December 31, 1987, 119 patients among a total number of 2309 were recorded prospectively, who needed induction of labour for mixed indications (Group A), for a premature rupture of the membrane (Group B) or for medical indication (Group C). Independently of the ripe of cervix the results were significantly better in the multiparae than nulliparae respecting the success of induction, the duration of labour and the rate of Caesarean sections. 66.4% (n = 79) of all cases could be delivered within 24 hours after the first gel-application. Statistically significant differences in the partial collectives A, B, and C were seen only by unripe cervix (A = 60.0%, B = 71.4%, C = 30.0%). Repeated tries of inductions led to statistically significant more rates of Caesarean sections, fever during labour and prolonged course of labour. The rate of Caesarean sections and the fetal post-partum results comparing to the other remaining deliveries in 1986/87 were statistically not different. Side effects induced by Prostaglandins were only founded in two cases concerning nausea. Uterine hyperactivities with pathological CTG-patterns being resistant to treatment with beta-mimetics were found in one case. As severe complication the only case with particular rupture of uterus must be seen. Based on our experience the intracervical PGE2-application for induction of labour is not disadvantageous for mother and fetus, if there are certain indications and fixed criteria.
authors.affiliation: Abteilung Gynäkologie und Geburtshilfe der Medizinischen Fakultät der RWTH Aachen.
authors.forename: C
authors.initials: C
authors.lastname: Stumpf
authors.forename: H
authors.initials: H
authors.lastname: Schonlau
authors.forename: F
authors.initials: F
authors.lastname: Hübner
authors.forename: P
authors.initials: P
authors.lastname: Kesternich
authors.forename: H
authors.initials: H
authors.lastname: Jung
mesh_terms: D000282:Administration, Intravaginal; D015148:Cardiotocography; D002584:Cervix Uteri / Q000187:drug effects*; D015232:Dinoprostone / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006340:Heart Rate, Fetal / Q000187:drug effects; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D011247:Pregnancy; D011446:Prospective Studies; D014590:Uterine Contraction / Q000187:drug effects
chemical_list: D015232:Dinoprostone
vernacular_title: Klinische Erfahrungen mit intracervikaler Prostaglandin E2-Applikation zur Geburtseinleitung.