title: [An experimental study on nerve repair using carbon dioxide laser].
abstract: Although microsurgical techniques of nerve suture are now widely practiced, the prognosis is not always satisfactory. We have therefore developed a new method using CO2 laser and fibrin film to evaluate its clinical availability by determining its adhesiveness and axonal regeneration. The sciatic nerve of Wistar rats was cleanly cut. Fibrin films that are not themselves at all adhesive were placed on the suture site and were firmly anastomosed by irradiating them with 70 mW laser energy. Measurement of the tensile strength has demonstrated that effective adhesiveness may be obtained for nerve repair. According to the postoperative quantitative evaluation of the number of myelinated fibers of larger size and the mean diameter of myelinated fibers, the laser method appears to be significantly better than the conventional suture methods. In conclusion, this laser method is useful for clinical application.
authors.affiliation: Department of Orthopedic Surgery, Hiroshima University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Osedo
mesh_terms: D000818:Animals; D005337:Fibrin / Q000627:therapeutic use; D053685:Laser Therapy; D008297:Male; D008722:Methods; D009412:Nerve Fibers / Q000473:pathology / Q000601:surgery*; D009416:Nerve Regeneration; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000601:surgery; D013718:Tensile Strength
chemical_list: D005337:Fibrin