Synthesis and pharmacological properties of some 2-(3-aminopropionyl)- and 2-(3-aminopropyl)-1-(3-pyridyl)-1,2,3,4-tetrahydro-beta-carbolines.
Five derivatives of 2-(3-aminopropionyl)-1-(3-pyridyl)-1,2,3,4-tetrahydro-beta-carboline (2a-e) were obtained, which yielded, as a result of reduction with LiAlH4, five respective 2-aminopropyl-derivatives (3a-e). Pharmacological studies revealed that phenylpiperazine-derivatives 2d, 2e, 3d and 3e have sedative and analgesic properties. All compounds are devoided of neuroleptic, antidepressant, anxiolytic and antiparkinsonic activity.
Misztal
S
S
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Boksa
J
J
Chojnacka-Wójcik
E
E
Tatarczyńska
E
E
Russeva
S
S
D000700:Analgesics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002243:Carbolines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006993:Hypnotics and Sedatives; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010147:Pain Measurement; D011437:Propylamines / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
D000700:Analgesics; D002243:Carbolines; D006993:Hypnotics and Sedatives; D011437:Propylamines; D011725:Pyridines