title: [Esophageal cancer and endoscopic sclerosis of esophageal varices: a fortuitous association?].
abstract: We report the case of 4 male patients, smokers, with alcoholic cirrhosis, mean age 54.7 +/- 6 years, treated by sclerotherapy for bleeding esophageal varices. Variceal eradication was obtained following juxtacardial intravariceal injection of 1.5 p. 100 polidocanol in one case (100 ml), and 0.5 p. 100 polidocanol in 3 cases (90, 240 and 310 ml). Local complications were observed in all patients (ulcers: 3; stenosis: 1). Carcinoma of the lower third of the esophagus was detected 12, 20, 22 and 30 months after esophageal sclerosis. Carcinoma was circular (one case), semicircular (2 cases), and nodular superimposed on Barrett's esophagus (one case). Histologic features included squamous cell carcinoma in 3 cases and adenocarcinoma in one case. Sclerotherapy could lead to the development of carcinoma because of mucosal alterations. However, other high risk factors (age, alcohol-tobacco intoxication, Barrett's esophagus) and different histologic features suggest a causal association. Endoscopic follow-up of patients after esophageal sclerosis could confirm this hypothesis.
authors.affiliation: Clinique des Maladies de l'Appareil Digestif, Hôpital Claude-Huriez, Lille.
authors.forename: F
authors.initials: F
authors.lastname: Guillemot
authors.forename: P
authors.initials: P
authors.lastname: Bonnière
authors.forename: J F
authors.initials: JF
authors.lastname: Bretagne
authors.forename: J P
authors.initials: JP
authors.lastname: Ancelin
authors.forename: J L
authors.initials: JL
authors.lastname: Raoul
authors.forename: C
authors.initials: C
authors.lastname: Plane
authors.forename: A
authors.initials: A
authors.lastname: Cortot
authors.forename: J C
authors.initials: JC
authors.lastname: Paris
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced*; D004938:Esophageal Neoplasms / Q000139:chemically induced*; D004932:Esophageal and Gastric Varices / Q000628:therapy*; D004945:Esophagoscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012597:Sclerosing Solutions / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D012597:Sclerosing Solutions
vernacular_title: Cancer oesophagien et sclérose endoscopique des varices oesophagiennes: une association forfuite?