Mechanism of hypouricemia in Hodgkin's disease. Isolated defect in postsecretory reabsorption of uric acid.
We present a patient with hypouricemia associated with Hodgkin's disease. Serum uric acid level ranged from 1.4 to 2.2 mg/dl and fractional excretion of uric acid was 26.5%. No other renal tubular abnormalities were found. The pyrazinamide suppression test came off normal. However, during the benzbromarone test, the uricosuric response was reduced. The abnormal renal handling of urate became normal following therapy of Hodgkin's disease. The findings suggest that hypouricemia in Hodgkin's disease is caused by an impairment of postsecretory tubular reabsorption of uric acid.
Tykarski
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Department of Cardiology, Medical Academy, Poznań, Poland.
D005260:Female; D006689:Hodgkin Disease / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007684:Kidney Tubules / Q000503:physiopathology; D008875:Middle Aged; D012016:Reference Values; D014527:Uric Acid / Q000097:blood* / Q000652:urine
D014527:Uric Acid