[Penetration of cefmetazole and netilmicin into the cerebrospinal fluid].
1. Cefmetazole (CMZ) and netilmicin (NTL) were administered by one-shot intravenous and intramuscular injection, respectively, and measurements were made on their concentrations in the serum as well in the cerebrospinal fluid (CSF) which was collected using a drainage tube inserted into the cisterna basalis after the operation of ruptured cerebral aneurysm. 2. Concentrations of CMZ and NTL in the CSF changed nearly in parallel to those in the serum. 3. A one-shot intravenous injection of these drugs seemed to achieve their high concentrations in the CSF, though high concentrations may not last very long.
Yoshino
K
K
Department of Neurosurgery, Sumitomo Betshi Hospital.
Fujita
K
K
Takemoto
M
M
Suga
M
M
D015311:Cefmetazole / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid*; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009428:Netilmicin / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid*
D015311:Cefmetazole; D009428:Netilmicin