Clindamycin therapy of cerebral toxoplasmosis in an AIDS patient.
A 47-year-old patient with AIDS and cerebral toxoplasmosis was treated with sulfadiazine pyrimethamine for 5 days. After developing a severe rash his regimen was changed to clindamycin 600 mg q 6 h intravenously and pyrimethamine 25 mg daily, given for 37 days. This resulted in improvement of clinical symptoms and complete resolution of CT scan abnormalities. Clindamycin combined with pyrimethamine may be a useful alternative therapy for cerebral toxoplasmosis in patients who can not tolerate sulfonamides.
Westblom
T U
TU
Marshall University School of Medicine, Department of Medicine, Huntington, West Virginia 25755-9410.
Belshe
R B
RB
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D001927:Brain Diseases / Q000188:drug therapy* / Q000209:etiology; D002981:Clindamycin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014123:Toxoplasmosis / Q000188:drug therapy* / Q000209:etiology
D002981:Clindamycin