Renal handling of amino acid 99mtechnetium chelates.
Four amino acids--alanine, 2,3-diaminopropionic acid, cystine, and cystein--and also one diamine, ethylenediamine, were chelated with 99m-technetium (99mTc), and their renal excretion patterns were studied in rabbits in the presence and absence of two renal tubular transport inhibitors, probenecid and 2,4-dinitrophenol. From the depression of renal excretion for the first three amino acid chelates, in the presence of the inhibitors, a renal tubular excretory pathway of elimination was suggested for these compounds. The renal excretions of 99mTc-cystein and 99mTc-ethylenediamine however, remained undepressed under similar experimental conditions. An explanation of these observations was forwarded from the possible chemical structures of these chelates.
Chattopadhyay
M
M
Indian Institute of Chemical Biology, Dept. of Nuclear Medicine, Calcutta.
Banerjee
S
S
D019297:2,4-Dinitrophenol; D000596:Amino Acids / Q000493:pharmacokinetics*; D004140:Dinitrophenols / Q000494:pharmacology; D007668:Kidney / Q000502:physiology*; D007684:Kidney Tubules / Q000187:drug effects; D007700:Kinetics; D011339:Probenecid / Q000494:pharmacology; D013667:Technetium / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D000596:Amino Acids; D004140:Dinitrophenols; D013667:Technetium; D011339:Probenecid; D019297:2,4-Dinitrophenol