Enhanced therapeutic tumour dose of 131I-MIBG by accelerated diuresis.
Different biokinetics of intravenously (i.v.) administered 131I-MIBG in the same patient, a child with abdominal neuroblastoma, is demonstrated with and without accelerated elimination by means of hyperhydration. By hyperhydration it was possible to increase the estimated tumour dose by a factor of 2.1 without affecting the whole body dose. The present results indicate that, if accelerated diuresis is implemented, higher radioactivity of 131I-MIBG can be administered and thereby an increased therapeutic tumour dose achieved.
Darte
L
L
Department of Radiophysics, University Hospital, Lund, Sweden.
Tennvall
J
J
D019797:3-Iodobenzylguanidine; D000008:Abdominal Neoplasms / Q000532:radiotherapy*; D002675:Child, Preschool; D004231:Diuresis; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007462:Iodobenzenes / Q000493:pharmacokinetics*; D009447:Neuroblastoma / Q000532:radiotherapy*; D013997:Time Factors
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine