title: Effects of adrenal demedullation on stress-induced hypertension and cardiovascular responses to acute stress.
abstract: Because chronic infusions of adrenalin (A) produce hypertension in rats, it has been suggested that A is a mediator of stress-induced hypertension. In order to test the hypothesis that lowering A will attenuate stress-induced hypertension, rats who had their adrenal medullae removed (ADM) and sham-operated controls were subjected to chronic stress. All subjects were offspring of a cross between spontaneously hypertensive and Wistar-Kyoto rats. Prior to chronic stress, systolic pressures were the same in the two groups. The stress consisted of 60 2-h sessions of shock-shock conflict during 18 weeks. After conflict stress, the rats were implanted with arterial catheters and allowed two days to recover. The resting mean arterial pressure (MAP) was 141.2 mmHg in the ADM group and 142.3 mmHg in the Sham group. Cardiovascular responses to acute stress were then examined. The rats were transferred to a test-box and subjected to pulsed foot shocks (0.5-s duration, 5-s intervals) for 5 min. The MAP increase after transfer was 22.3% in the ADM and 4.2% in the Shams (P less than 0.001). After termination of the shocks, the MAP was elevated 22.2% above baseline in the ADM and 8.1% in the Shams (P less than 0.02). Five minutes after foot shocks the MAP increase was 21.6% in the ADM and 7.2% in the Shams (P less than 0.02). Adrenal demedullation was effective in attenuating plasma A during stress and reduced the plasma noradrenaline response. Therefore, the larger pressor responses of the ADM group seem to result from attenuation of beta-adrenoreceptor-mediated dilation of skeletal muscle vasculature.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Psychology, University of Iowa, Iowa City 52242.
authors.forename: S
authors.initials: S
authors.lastname: Knardahl
authors.forename: B J
authors.initials: BJ
authors.lastname: Sanders
authors.forename: A K
authors.initials: AK
authors.lastname: Johnson
mesh_terms: D000313:Adrenal Medulla / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure; D002395:Catecholamines / Q000097:blood; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013312:Stress, Physiological / Q000503:physiopathology*
chemical_list: D002395:Catecholamines