Is bone marrow biopsy a prognostic parameter in B-CLL?
Four hundred and ninety-three bone marrow biopsies from CLL patients were analysed on the basis of non diffuse versus diffuse bone marrow lymphocytic infiltration patterns. In each clinical stage A, B, and C there were non significant differences in survival rates according to the bone marrow pattern. However in stage A studying the evolution to stage B or C, a significant difference between patients with non diffuse and diffuse pattern was observed.
Raphael
M
M
Département d'Hématologie, CHU Pitié-Salpêtrière, Paris, France.
Chastang
C
C
Binet
J L
JL
D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000145:classification / Q000473:pathology*; D011379:Prognosis