title: Involvement of calcium in flavonoid analgesia.
abstract: Calcium has been reported to play a key role in opioid analgesia. Several flavonoids also elicit an analgesic effect through the opioid system. The involvement of calcium in the analgesic activity of these flavonoid compounds was now investigated. Calcium antagonised the analgesic action of flavonoids while nifedipine, a calcium channel blocker, potentiated it. This suggests a possible role for calcium in the analgesic action of flavonoids as with that of morphine.
authors.affiliation: Medicinal Chemistry Research Centre, Madras Medical College, India.
authors.forename: P
authors.initials: P
authors.lastname: Thirugnanasambantham
authors.forename: S
authors.initials: S
authors.lastname: Viswanathan
authors.forename: S
authors.initials: S
authors.lastname: Ramaswamy
authors.forename: V
authors.initials: V
authors.lastname: Krishnamurthy
authors.forename: C I
authors.initials: CI
authors.lastname: Mythirayee
authors.forename: S
authors.initials: S
authors.lastname: Ramachandran
authors.forename: L
authors.initials: L
authors.lastname: Kameswaran
mesh_terms: D000700:Analgesics; D000818:Animals; D002118:Calcium / Q000502:physiology*; D005419:Flavonoids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology
chemical_list: D000700:Analgesics; D005419:Flavonoids; D009020:Morphine; D009543:Nifedipine; D002118:Calcium