The role of cernitins in cadmium effect on the absorption processes in rat small intestine.
The effect of long-term intoxication of cadmium (administered subcutaneously in a dose of 1 mg Cd/kg of body weight once a week for one month) on the absorption of water, sodium, potassium, glucose, glycine and thiamine in the small intestine of rats was investigated. In addition, the influence of cernitins (special pollen extract) on the action of cadmium intoxication was tested. The cernitins were given by stomach pump in the form of an aqueous solution of Pollitabs Sport tablets in a dose of 1.5 mg of cernitin T-60 and 0.075 mg of cernitin GBX per individual twice a week for two weeks or four weeks according to the group of animals tested. The results indicated that long-term administration of cadmium increased the intestinal absorption of all tested substances. Meanwhile, the application of cernitins reduced the effects of cadmium intoxication upon intestinal absorption and the processes of absorption was close to normal.
Howaniec
M
M
Chair of Human and Animal Physiology, Silesian University, Katowice.
Mekail
A
A
Chroszcz
G
G
D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010936:Plant Extracts; D011058:Pollen; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012434:Secale; D012964:Sodium / Q000378:metabolism; D013831:Thiamine / Q000378:metabolism
D010936:Plant Extracts; D002104:Cadmium; C010070:cernilton; D012964:Sodium; D005947:Glucose; D011188:Potassium; D005998:Glycine; D013831:Thiamine