Studies on the effect of ethanol and/or toluene on rat erythrocytes.
Rats were subjected to a chronic ethanol exposure in their drinking water for 8 months and then a short subacute toluene exposure to 12,000 mg/m3 for 5 h/day for nine days. Combined exposure increased the reticulocyte count and the concentration of haemoglobin, and changed the biochemical/biophysical properties of red blood cells. Macrocytosis and a decrease in erythrocyte membrane lipid fluidity in the middle zone of the lipid bilayer were the most useful indices of exposure.
Rosin
J
J
Department of Biochemistry, Institute of Occupational Medicine, Lódź, Poland.
Bartosz
G
G
Wrońska-Nofer
T
T
D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D001772:Blood Cell Count; D004435:Eating / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D000431:Ethanol / Q000633:toxicity*; D008055:Lipids / Q000097:blood; D008297:Male; D009996:Osmotic Fragility; D051381:Rats; D011919:Rats, Inbred Strains; D014050:Toluene / Q000633:toxicity*
D008055:Lipids; D014050:Toluene; D000431:Ethanol; D000110:Acetylcholinesterase