title: Selective concentration of anti-Purkinje cell antibody in the CSF of two patients with paraneoplastic cerebellar degeneration.
abstract: An anti-Purkinje cell antibody (APCA) was found in serum and CSF of 2 patients with paraneoplastic cerebellar degeneration (PDC) and breast carcinoma. Integrity of the blood-brain barrier (BBB) was normal in one patient and slightly damaged in the other. In both patients CSF IgG index was normal, but CSF/serum APCA ratio and CSF IgG APCA index were elevated suggesting that a selective concentration of the APCA in CSF occurs in patients with PCD. This feature supports the hypothesis that APCA may play a role in the pathogenesis of PCD.
authors.affiliation: Department of Neurology, Hospital Clinic i Provincial, Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Graus
authors.forename: O G
authors.initials: OG
authors.lastname: Segurado
authors.forename: E
authors.initials: E
authors.lastname: Tolosa
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000134:cerebrospinal fluid*; D001812:Blood-Brain Barrier; D001943:Breast Neoplasms / Q000276:immunology*; D002524:Cerebellar Ataxia / Q000276:immunology; D002526:Cerebellar Diseases / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D010257:Paraneoplastic Syndromes / Q000276:immunology*; D011689:Purkinje Cells / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G