Azidothymidine inhibits mitogen stimulated growth and DNA-repair in human peripheral lymphocytes.
Until now, 3'-Azido-3'-deoxythymidine (AZT) is the most widely used drug in AIDS therapy, but the positive anti HIV effect of the drug is often accompanied by severe side effects such as bone-marrow suppression. In the present study, the effect of AZT on UV induced DNA strand-break rejoining and on phytohemagglutinin stimulated growth of lymphocytes from 7 healthy volunteers has been examined, and inhibitory effects of the drug was observed at therapeutic concentrations, i.e. 1-10 uM AZT.
Munch-Petersen
B
B
Institute of Life Sciences & Chemistry, Roskilde University, Denmark.
D000293:Adolescent; D000328:Adult; D002455:Cell Division / Q000187:drug effects; D003561:Cytarabine / Q000494:pharmacology; D004249:DNA Damage / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology*; D014466:Ultraviolet Rays; D015215:Zidovudine / Q000494:pharmacology*
D010835:Phytohemagglutinins; D003561:Cytarabine; D015215:Zidovudine