Spinal cord regeneration: new experimental approach.
An experimental study was conducted to enhance regeneration in the spinal cord. Twenty Swiss albino rats were used, of which 8 were controls, and hemicordotomy was performed at mid-thoracic level. In 12 rats a segment of peripheral nerve (sciatic) autograft was taken, minced and implanted in the hemicordotomy site. All the rats were sacrificed at 4-12 weeks. Fixation was carried out by intracardiac perfusion of fixative. Light microscopy was used to study the hemicordotomy site. Two observations were made; first, regeneration of the cord was greatly enhanced, and second, the spinal cord caudal to the hemicordotomy did not disintegrate in the grafted cords.
Khalili
A H
AH
Department of Surgery (Neurosurgery), College of Medicine, Baghdad University, Iraq.
Hamash
M H
MH
D000818:Animals; D009412:Nerve Fibers / Q000502:physiology; D009416:Nerve Regeneration; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000473:pathology / Q000502:physiology / Q000637:transplantation; D013116:Spinal Cord / Q000473:pathology / Q000502:physiology*