title: Acute cytogenetic effects of potassium bromate on rat bone marrow cells in vivo.
abstract: The acute cytogenetic effects of potassium bromate (KBrO3) on rat bone marrow cells in vivo were studied. The incidence of chromosome aberrations in bone marrow cells increased rapidly, reaching a maximum level 12 h after intraperitoneal injection and decreased within 24 h. Dose-response relationships were obtained for both intraperitoneal and oral administrations.
authors.affiliation: Department of Natural Science, Osaka Women's University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Fujie
authors.forename: H
authors.initials: H
authors.lastname: Shimazu
authors.forename: M
authors.initials: M
authors.lastname: Matsuda
authors.forename: T
authors.initials: T
authors.lastname: Sugiyama
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001959:Bromates / Q000008:administration & dosage / Q000494:pharmacology*; D001966:Bromine / Q000494:pharmacology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats
chemical_list: D001959:Bromates; C019536:potassium bromate; D001966:Bromine