A model of atrial ectopic tachycardia in the rat.
A model of atrial ectopic tachycardia (AET) in the adult rat is described. Pentobarbital-anesthetized adult male rats given digoxin 30 mg/kg s.c. develop AET 50 min after administration. Heart rate and rhythm were determined by electrocardiography using limb leads, I, II and III. This model of AET is simple, sustained and economical. As a supplement to models of ventricular arrhythmias, this model might broaden the pre-clinical evaluation of antiarrhythmic agents.
Tribble
J
J
Medical College of Wisconsin, Department of Pediatrics, Milwaukee.
Weinhouse
E
E
Jarenwattananon
M
M
Nudel
D B
DB
D000818:Animals; D004077:Digoxin / Q000494:pharmacology; D004195:Disease Models, Animal; D004562:Electrocardiography; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013612:Tachycardia, Ectopic Atrial / Q000503:physiopathology*; D013617:Tachycardia, Supraventricular / Q000503:physiopathology*
D004077:Digoxin