Effect of pefloxacin on adherence of Proteus-Providencia spp to squamous epithelial cells.
Pefloxacin, a new piperazinyl substituted quinolone derivative, reduced at sub-MICs (Minimal Subinhibitory Concentrations: four times lower than Minimal Inhibitory Concentrations) the in vitro adherence of Proteus-Providencia spp. to squamous epithelial cells obtained from the urinary tract. The decrease of adherence was about 30% and 50% after 1 h and, respectively, 16-18 h of incubation with pefloxacin. This finding suggests that pefloxacin may play a role in determining the in vivo adhesion of Proteus-Providencia spp. on the urinary tract and consequently the expression of bacterial pathogenic potency.
Cellini
L
L
Istituto di Medicina Sperimentale, Facoltà di Medicina e Chirurgia, Università G. D'Annunzio, Chieti, Italy.
Piccolomini
R
R
Allocati
N
N
Di Girolamo
A
A
Catamo
G
G
D000328:Adult; D001422:Bacterial Adhesion / Q000187:drug effects*; D004847:Epithelial Cells; D005260:Female; D006801:Humans; D015366:Pefloxacin / Q000494:pharmacology*; D011511:Proteus / Q000187:drug effects* / Q000302:isolation & purification; D011532:Providencia / Q000187:drug effects* / Q000302:isolation & purification; D014552:Urinary Tract Infections / Q000382:microbiology
D015366:Pefloxacin