title: Nucleolar organizer regions in melanocytic dysplasia and melanoma.
abstract: Using silver (Ag) staining to demonstrate nucleolar organizer region-associated proteins (AgNORs), pigmented naevi exhibiting features of melanocytic dysplasia have been examined and compared with benign intradermal and compound naevi and with malignant melanomas. A highly significant difference was found between the numbers of AgNORs demonstrated in benign naevus cells and atypical melanocytes and in malignant melanocytes, suggesting that this technique may have a role in differentiating between difficult melanocytic lesions.
authors.affiliation: Department of Histopathology, St George's Hospital, London, UK.
authors.forename: M E
authors.initials: ME
authors.lastname: Fallowfield
authors.forename: A R
authors.initials: AR
authors.lastname: Dodson
authors.forename: M G
authors.initials: MG
authors.lastname: Cook
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D008544:Melanocytes / Q000473:pathology* / Q000648:ultrastructure; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure; D009697:Nucleolus Organizer Region / Q000648:ultrastructure*; D012834:Silver
chemical_list: D012834:Silver