title: Eosinophilic granulomatous lymphadenopathy: association with hyper-IgE and eosinophilia.
abstract: Cervical lymph node enlargement is probably the most frequently detected childhood lymphadenopathy. We report 2 cases of cervical lymphadenopathy in children associated with hyper-IgE and eosinophilia, displaying the features of necrotizing eosinophilic granulomatosis. Immunohistochemical analysis and a serological work-up failed to elucidate the underlying etiology. We would like to call the attention of physicians and pathologists to this unusual clinical picture, different from the fatal form of necrotizing eosinophilic granulomatosis, and we suggest a role for the eosinophils in the pathologic appearance of the lymph nodes.
authors.affiliation: Sambur Center for Pediatric Hematology and Oncology, Petah Tikva, Israel.
authors.forename: C
authors.initials: C
authors.lastname: Kaplinsky
authors.forename: C
authors.initials: C
authors.lastname: Mor
authors.forename: I J
authors.initials: IJ
authors.lastname: Cohen
authors.forename: Y
authors.initials: Y
authors.lastname: Goshen
authors.forename: R
authors.initials: R
authors.lastname: Zaizov
authors.forename: D
authors.initials: D
authors.lastname: Atias
mesh_terms: D002675:Child, Preschool; D004802:Eosinophilia / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D004803:Eosinophilic Granuloma / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007073:Immunoglobulin E; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008206:Lymphatic Diseases / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D008297:Male; D009333:Neck
chemical_list: D007073:Immunoglobulin E