Fetal alcohol syndrome in rats: conditions for improvement of ethanol effects on fetal cerebral development with supplementary agents.
As a possible preventative measure for brain dysfunction in the fetal alcohol syndrome, the effect of zinc or vitamin E supplementation together with ethanol on the fetal cerebrum was investigated in rats. Contrary to our previously published data showing the good effect of 0.01% zinc with 30% ethanol on fetuses, the administration of 0.01% zinc with 20% ethanol, 0.03% vitamin E with 20% ethanol or 0.02% vitamin E with 10% ethanol during pregnancy did not result in a good effect on the body and cerebral weights of fetuses on gestational day 21. The development of dendritic branches on frontal cerebral neurons in fetuses was decreased in the order of the control, zinc with ethanol and ethanol groups. The concentration and content of alpha-tocopherol were increased, but those of zinc were not, in the fetal cerebrum with the maternal administration of vitamin E or zinc together with ethanol, respectively. These results suggest that the improvement of the brain function might depend on the deficient agent induced by maternal ethanol ingestion.
Tanaka
H
H
Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.
Iwasaki
S
S
Nakazawa
K
K
Inomata
K
K
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000033:anatomy & histology / Q000196:embryology* / Q000378:metabolism; D000431:Ethanol / Q000009:adverse effects* / Q000378:metabolism; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000188:drug therapy*; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D009929:Organ Size; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000378:metabolism / Q000627:therapeutic use*; D015032:Zinc / Q000378:metabolism / Q000627:therapeutic use*
D014810:Vitamin E; D000431:Ethanol; D015032:Zinc