title: Paired helical filaments and the cytoplasmic-nuclear interface in Alzheimer's disease.
abstract: The cytoplasmic-nuclear interface has been investigated by conventional thin sectioning electron microscopy of neurons from frontal lobe biopsies of 13 patients with Alzheimer's disease. Nine patients were in the early and intermediate stages of the disease and four patients in the advanced stage. Fascicles of paired helical filament-like strands and paired helical filaments appose the nuclear envelope, the nuclear pore complexes and the perinuclear polysomes. Paired helical filament profiles have also been identified in the nucleoplasm. These observations indicate that the cytoplasmic-nuclear interface and, consequently, the relationships between the cytoplasm and the nucleus, might be impaired in Alzheimer's disease.
authors.affiliation: Department of Pathology, Faculty of Health Sciences, University of Ottawa, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Metuzals
authors.forename: Y
authors.initials: Y
authors.lastname: Robitaille
authors.forename: S
authors.initials: S
authors.lastname: Houghton
authors.forename: S
authors.initials: S
authors.lastname: Gauthier
authors.forename: R
authors.initials: R
authors.lastname: Leblanc
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology*; D001706:Biopsy; D002467:Cell Nucleus / Q000648:ultrastructure*; D003593:Cytoplasm / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000648:ultrastructure*; D005625:Frontal Lobe / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D009474:Neurons / Q000648:ultrastructure