[Experimental studies on pharmacokinetics and tissue concentration of cis-dichlorodiammineplatinum (II) (CDDP) by intra-arterial infusion with hemostasis].
We have combined intra-arterial infusion with tourniquet techniques that produce hemostasis at the periphery of a tumor to accelerate penetration and adherence of the antitumor drug in the tumor. In the present study, MRMT-1 breast cancer was transplanted into the distal end of the femur of S-D rats to produce a bone tumor. Then cis-dichlorodiammineplatinum (II) (CDDP) was given in three ways: 1) systemic administration, 2) local intra-arterial infusion and 3) intra-arterial infusion with hemostasis, and the CDDP levels were determined of the tumor, kidney, lung and blood. The intra-tumoral CDDP level was found to be the highest in the group maintained with hemostasis, but that there was no significant difference in the levels in blood, the kidney and the lung among the three ways of administration. It was thus inferred that, though this method is effective in elevating the intra-tumoral CDDP level, sufficient hydration is necessary to prevent the same side effects as the other two methods.
Tomizawa
Y
Y
Department of Orthopaedic Surgery, Nihon University School of Medicine, Tokyo, Japan.
D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D005266:Femoral Neoplasms / Q000097:blood / Q000378:metabolism*; D006487:Hemostasis; D007261:Infusions, Intra-Arterial; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D009368:Neoplasm Transplantation; D051381:Rats
D002945:Cisplatin