[Biokinetics of magnetic carriers for directed transport of drugs].
Localization of intravenously injected magnetic drug carriers in the affected areas of the host is complicated by the carrier capture in the liver and other nonaffected organs and tissues. In vivo kinetics of radiolabeled magnetically targeted drug carriers was studied and one-exponent kinetics was shown. A mathematical model of the carrier capture in animal tissues based on the capture mechanism and mass transfer processes in circulating blood was proposed. Biodistribution and capture intensity of carbohydrate-and albumin-coated magnetic microparticles of different sizes were compared. A one-animal biokinetic test based on the model proposed proved to be effective in detecting insignificant differences in the magnetic carrier biokinetics usually hidden by individual differences of the animals.
Papisov
M I
MI
Svel'ev
V Iu
VIu
Segienko
V B
VB
Torchilin
V P
VP
D000818:Animals; D004337:Drug Carriers; D007700:Kinetics; D008280:Magnetics; D011817:Rabbits; D014018:Tissue Distribution
D004337:Drug Carriers
Biokinetika magnitnykh nositeleĭ dlia napravlennogo transporta lekarstv.