title: Behavioral activity during prolonged hypoxemia in fetal sheep.
abstract: Experiments were conducted in unanesthetized, chronically catheterized pregnant sheep to determine the fetal behavioral response to prolonged hypoxemia produced by restricting uterine blood flow. Uterine blood flow was reduced by adjusting a vascular occluder placed around the maternal common internal iliac artery to decrease fetal arterial O2 content from 6.1 +/- 0.3 to 4.1 +/- 0.3 ml/dl for 48 h. Associated with the decrease in fetal O2 content, there was a slight increase in fetal arterial PCO2 and decrease in pH, which were both transient. There was an initial inhibition of both fetal breathing movements and eye movements but no change in the pattern of electrocortical activity. After this initial inhibition there was a return to normal incidence of both fetal breathing movements and eye movements by 16 h of the prolonged hypoxemia. These studies indicate that the chronically catheterized sheep fetus is able to adapt behaviorally to a prolonged decrease in arterial O2 content secondary to the restriction of uterine blood flow.
authors.affiliation: Department of Obstetrics and Gynecology, University of Western Ontario, Lawson Research Institute, St. Joseph's Health Centre, London, Canada.
authors.forename: A D
authors.initials: AD
authors.lastname: Bocking
authors.forename: R
authors.initials: R
authors.lastname: Gagnon
authors.forename: K M
authors.initials: KM
authors.lastname: Milne
authors.forename: S E
authors.initials: SE
authors.lastname: White
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005133:Eye Movements; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005324:Fetal Movement; D005333:Fetus / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000150:complications / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D012132:Respiratory Muscles / Q000503:physiopathology; D012756:Sheep
chemical_list: D001786:Blood Glucose; D010100:Oxygen