Identification of a novel oligosaccharide backbone structure with a galactose residue monosubstituted at C-6 in human foetal gastrointestinal mucins.
An oligosaccharide purified from a major penta- to hexa-saccharide fraction of human meconium glycoproteins has been shown by m.s. and n.m.r. analysis to have a novel backbone structure containing an internal galactose residue monosubstituted at C-6 by N-acetylglucosamine: (Formula: see text). This oligosaccharide may represent a biosynthetic product of a previously unrecognized N-acetylglucosaminyltransferase catalysing formation of a linear GlcNAc beta 1-6Gal sequence.
Hounsell
E F
EF
Section of Glycoconjugate Research, Clinical Research Centre, Harrow, U.K.
Lawson
A M
AM
Feeney
J
J
Cashmore
G C
GC
Kane
D P
DP
Stoll
M
M
Feizi
T
T
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006801:Humans; D007231:Infant, Newborn; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008470:Meconium / Q000032:analysis*; D009077:Mucins / Q000032:analysis*; D009844:Oligosaccharides / Q000032:analysis*
D009077:Mucins; D009844:Oligosaccharides