title: Ten-year-replicated circadian profiles for 36 physiological, serological and urinary variables in healthy men.
abstract: At 3-hr intervals over a 24-hr span, 36 systemic, serologic and urinary variables were examined in 7 men in their mid 20's in the Spring of 1969, and again in the same 7 men in the Spring of 1979 under a similar chronobiologic protocol, using the same chemical and numerical analytical procedures. The variables examined for rhythms by cosinor were: vital signs--blood pressure (systolic, diastolic, pulse pressure and mean arterial pressure), heart rate, intraocular pressure (left and right), oral temperature; serum components--albumin, albumin/globulin ratio, total bilirubin, calcium, carbon dioxide, chlorides, bilirubin, cholesterol, globulin, glucose, potassium, sodium, sodium/potassium ratio, transaminase, triglycerides, total protein, urea nitrogen; and urine components--calcium, calcium/magnesium ratio, creatinine, magnesium, pH, potassium, sodium, sodium/potassium ratio, urea clearance, urea nitrogen, volume and zinc. Although all subjects appeared clinically healthy in 1969 and in 1979, certain inter-study differences were observed in a number of rhythm parameters of different variables. Statistically significant increases in mesor for the group as a whole were observed for serum Ca, cholesterol, Cl, CO2, K, Na, and while statistically significant mesor decreases for a group as a whole were noted in serum glucose and transaminase. Statistically significant increases in amplitude for the group as a whole were observed in serum chloride and urinary Na/K ratio, while statistically significant decreases were observed in amplitude for blood pressure, heart rate, serum albumin, A/G ratio, globulin, glucose, protein, sodium and transaminase.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Nuclear Medicine Service, Veterans Administration Hospital, Hines, IL 60141.
authors.forename: E L
authors.initials: EL
authors.lastname: Kanabrocki
authors.forename: R B
authors.initials: RB
authors.lastname: Sothern
authors.forename: L E
authors.initials: LE
authors.lastname: Scheving
authors.forename: F
authors.initials: F
authors.lastname: Halberg
authors.forename: J E
authors.initials: JE
authors.lastname: Pauly
authors.forename: J
authors.initials: J
authors.lastname: Greco
authors.forename: B A
authors.initials: BA
authors.lastname: Nemchausky
authors.forename: M
authors.initials: M
authors.lastname: DeBartolo
authors.forename: E
authors.initials: E
authors.lastname: Kaplan
authors.forename: J B
authors.initials: JB
authors.lastname: McCormick
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001798:Blood Proteins / Q000032:analysis; D001806:Blood Urea Nitrogen; D001831:Body Temperature; D002940:Circadian Rhythm; D004573:Electrolytes / Q000097:blood / Q000652:urine; D006339:Heart Rate; D006801:Humans; D007429:Intraocular Pressure; D008055:Lipids / Q000097:blood; D008297:Male; D012016:Reference Values; D000637:Transaminases / Q000097:blood; D014508:Urea / Q000652:urine
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D004573:Electrolytes; D008055:Lipids; D014508:Urea; D000637:Transaminases