title: Changes in ventricular function and coronary stenosis after successful intravenous thrombolysis in acute myocardial infarction.
abstract: Temporal changes in residual stenosis in the infarct-related coronary artery and ventricular function were studied in 30 consecutive patients with an acute myocardial infarction who received rapid, high dose intravenous infusions of streptokinase within 4 h of pain onset. Patients were studied 6 days and 3.9 +/- 1.3 months after the acute episode. Inferior infarction, early thrombolysis (less than 1.5 h after pain onset) and adequate reperfusion (less than 75% residual stenosis in the infarct-related coronary artery) were associated with smaller left ventricular infarcts, smaller ventricular volumes and better ventricular function. Residual stenosis tended to increase with time and in 6 patients the artery closed completely (1 with an overt clinical episode). Ventricular function and volumes improved progressively in patients with good initial function and less residual stenosis in the infarct-related coronary artery.
authors.affiliation: Cardiac Department, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: C
authors.initials: C
authors.lastname: Lotan
authors.forename: J
authors.initials: J
authors.lastname: Gurevitz
authors.forename: M
authors.initials: M
authors.lastname: Mosseri
authors.forename: T A
authors.initials: TA
authors.lastname: Weiss
authors.forename: S
authors.initials: S
authors.lastname: Welber
authors.forename: D
authors.initials: D
authors.lastname: Sapoznikov
authors.forename: S
authors.initials: S
authors.lastname: Rosenheck
authors.forename: D
authors.initials: D
authors.lastname: Admon
authors.forename: Y
authors.initials: Y
authors.lastname: Hasin
authors.forename: M S
authors.initials: MS
authors.lastname: Gotsman
mesh_terms: D000368:Aged; D003251:Constriction, Pathologic / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D013300:Streptokinase / Q000627:therapeutic use*; D013318:Stroke Volume / Q000187:drug effects*; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D013300:Streptokinase