[The immunodepressive and lympholytic action of kortifen].
The study of the effect of a new antitumor drug cortifen on humoral immunity in experiments on CBA mice showed that it is a potent and long acting immunodepressant. The degree of immunity depression was found to be drug dose-dependent. The hormonal components of cortifen failed to exert the immunodepressive action. The alkylating component, chlorphenacyl, on the contrary, had the immunostimulating effect.
Pykhtina
A A
AA
Gladkova
N E
NE
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003345:Corticosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations / Q000494:pharmacology; D007114:Immunization; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008196:Lymph / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013329:Structure-Activity Relationship; D013997:Time Factors
D000970:Antineoplastic Agents; D004338:Drug Combinations; D007166:Immunosuppressive Agents; D009588:Nitrogen Mustard Compounds; C058175:cortifen; C008826:phenacid; D003345:Corticosterone
Immunodepressivnoe i limfoliticheskoe deĭstvie kortifena.