Beta-adrenoceptor blockade does not modify gastrointestinal transit time in healthy volunteers.
The effect of non-selective beta-adrenoceptor blockade on gastrointestinal transit time (GITT) was measured in 20 healthy volunteers with a radiographic method. By means of double-blind, crossover technique, each subject was studied during treatment with 80 mg oral propranolol or placebo twice daily for 7 days. The number of radiopaque markers retained in the alimentary tract did not differ significantly between the placebo and the propranolol periods. The mean GITT for placebo was 78 h and for propranolol 77 h. During propranolol treatment the heart rate and blood pressure were significantly decreased. It is concluded that non-selective beta-adrenoceptor blockade does not influence human gastrointestinal transit time under unstrained conditions.
Hallerbäck
B
B
Dept. of Surgery, Norra Alvsborgs Länslasarett, Trollhättan, Sweden.
Glise
H
H
Karlsson
F
F
Tegnebjer
M
M
D000328:Adult; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D008297:Male; D011433:Propranolol / Q000009:adverse effects / Q000494:pharmacology*; D011897:Random Allocation
D011433:Propranolol