Metabolic acetylation of phenelzine in rats.
1-Acetyl-2-(2-phenylethyl)hydrazine (N2-acetylphenelzine) is identified as an acetylated metabolite of phenelzine in the rat. One hour after intraperitoneal administration of a high dose of phenelzine sulfate to rats, the blood and brain of the animals were extracted and analyzed by combined gas chromatography/electron impact mass spectrometry in the total ion and selected ion modes. This procedure provided unequivocal proof of the presence of N2-acetylphenelzine in these tissues. The other possible monoacetylated metabolite of phenelzine, 1-acetyl-1-(2-phenylethyl)hydrazine (N1-acetylphenelzine), and the diacetylated derivative, 1,2-diacetyl-2-(2-phenylethyl)hydrazine, were sought, but were not detected.
Mozayani
A
A
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
Coutts
R T
RT
Danielson
T J
TJ
Baker
G B
GB
D000107:Acetylation; D000818:Animals; D001921:Brain / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D010624:Phenelzine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
C043198:N-acetylphenelzine; D010624:Phenelzine