Toxicity of astatine-211 in the mouse.
The toxicity of the alpha particle emitting halogen astatine-211 was examined in male and female mice. Pathological changes were seen in mice killed at 14 days and/or at 56 days following a single injection of 61 kBq211 At per g body weight. The tissues affected, in order of severity were: spleen, lymph nodes, bone marrow, gonads, thyroid, salivary glands and stomach.
Cobb
L M
LM
Division of Experimental Pathology and Therapeutics, MRC Radiobiology Unit, Didcot, Oxon, UK.
Harrison
A
A
Butler
S A
SA
D000818:Animals; D001246:Astatine / Q000627:therapeutic use / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D001246:Astatine