Mechanism of the protective action of taurine against isoprenaline induced myocardial damage.
The effect of the sulphur amino acid, taurine, on the biochemical changes induced by a toxic dose of isoprenaline was examined in chick hearts. Isoprenaline treatment (80 and 240 mg.kg-1 subcutaneously twice a day for four days) caused a dose dependent increase in heart to body weight ratio. Isoprenaline administration induced a substantial accumulation of calcium and caused a profound decrease of adenosine triphosphate content and creatine phosphokinase activity in the myocardium. A pronounced increase in lipoperoxide and decrease in phospholipid and reduced glutathione concentrations were also seen. Oral administration of taurine (200 mg.kg-1 for seven days) partially protected against these changes induced by isoprenaline. It is suggested that the beneficial effect of taurine may be due in part to inhibition of lipoperoxide formation and calcium accumulation and to protection against the deterioration of membrane phospholipids.
Ohta
H
H
Third Department of Internal Medicine, Osaka University Medical School, Japan.
Azuma
J
J
Awata
N
N
Hamaguchi
T
T
Tanaka
Y
Y
Sawamura
A
A
Kishimoto
S
S
Sperelakis
N
N
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D002645:Chickens; D003402:Creatine Kinase / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D007545:Isoproterenol / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D013654:Taurine / Q000494:pharmacology*
D010743:Phospholipids; D013654:Taurine; D008315:Malondialdehyde; D000255:Adenosine Triphosphate; D003402:Creatine Kinase; D005978:Glutathione; D007545:Isoproterenol; D002118:Calcium