Antimetastatic effect of amiloride in an animal tumour model.
The diuretic Amiloride competitively inhibits the catalytic activity of the urokinase-type plasminogen activator on plasminogen in vitro. This effect was tested on a rat adenocarcinoma model and its invasive potential in the host lung. While the inhibitory effect on intact cell cultures of the tumour was slight, continuous exposure of tumour-injected animals to the drug completely prevented the formation of lung metastasis.
Kellen
J A
JA
Department of Clinical Biochemistry, Sunnybrook Medical Centre, University of Toronto, Ontario, Canada.
Mirakian
A
A
Kolin
A
A
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology*; D000584:Amiloride / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents; D005260:Female; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology*; D009362:Neoplasm Metastasis; D051381:Rats; D011916:Rats, Inbred F344
D000970:Antineoplastic Agents; D000584:Amiloride