Chromogranins A and B and secretogranin II in hormonally identified endocrine cells of the gut and the pancreas.
Chromogranins A and B and secretogranin II have been localized in a wide spectrum of gastroenteropancreatic endocrine/paracrine cells. Chromogranin A immunoreactivity showed the widest distribution and was displayed by glucagon-, PP-, gastrin-, gastrin-CCK-, secretin-immunoreactive cells, the most intense stainings being peculiar of enterochromaffin cells. Chromogranin B immunoreactivity was detected in gastrin- and glucagon cells and in some enterochromaffin cells containing also chromogranin A. Secretogranin II was paired to chromogranin A in glucagon cells of pancreatic islets or occurred alone in glycentin/PP cells of colonic mucosa. Neither of the chromogranins nor secretogranin II have been so far detected in somatostatin-, GIP-, or motilin-immunoreactive cells. Chromogranin A but not chromogranin B or secretogranin II has been detected in the gastric argyrophilic ECL cells.
Buffa
R
R
Centro di Diagnostica Istochimica ed Ultrastrutturale, Università di Pavia, Italy.
Marè
P
P
Gini
A
A
Salvadore
M
M
D000818:Animals; D002415:Cats; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis*; D003106:Colon / Q000032:analysis; D004064:Digestive System / Q000032:analysis*; D004285:Dogs; D004702:Endocrine Glands / Q000032:analysis*; D005753:Gastric Mucosa / Q000032:analysis; D006168:Guinea Pigs; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000032:analysis; D007421:Intestine, Small / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis*; D010179:Pancreas / Q000032:analysis*; D011506:Proteins / Q000032:analysis*; D014018:Tissue Distribution
D053379:Chromogranin A; D002864:Chromogranins; D009419:Nerve Tissue Proteins; D011506:Proteins