title: Effects of intracerebroventricular infusion of angiotensin II and related peptides on water and sodium ingestion and excretion.
abstract: The objective of the present study was to investigate the effects of an angiotensin II (AII) analogue, Des-Asp1-AII and of two competitive blockers, [Leu8]-AII and [octanoyl-Leu8]-AII, infused intracerebroventricularly on the ingestion of water and of a 3% NaCl solution, as well as on diuresis and natriuresis in normal rats and in adrenalectomized and deoxycorticosterone (DOCA)-treated rats. Both AII and Des-Asp1-AII increased water and 3% NaCl intake and increased urine and Na+ excretion, the effect of AII being more intense. Except for 3% NaCl, the responses of all other parameters were totally or partially reduced by previous treatment with [Leu8]-AII or [octanoyl-Leu8]-AII. Subcutaneous DOCA injection caused water ingestion. Previous treatment with DOCA increased the response to AII for the ingestion of 3% NaCl and inhibited sodium excretion. The results obtained for adrenalectomized rats treated with DOCA, AII and analogous agonists did not differ from those observed in normal rats. These data suggest a possible synergism between the cerebral and renal renin-angiotensin systems in the regulation of the physiological parameters studied.
authors.affiliation: Departamento de Ciências Fisiológicas, Faculdade de Odontologia de Araraquara, UNESP, SP, Brasil.
authors.forename: J R
authors.initials: JR
authors.lastname: Gonçalves
authors.forename: L A
authors.initials: LA
authors.lastname: Camargo
authors.forename: J V
authors.initials: JV
authors.lastname: Menani
authors.forename: W A
authors.initials: WA
authors.lastname: Saad
authors.forename: W A
authors.initials: WA
authors.lastname: Saad
authors.forename: A
authors.initials: A
authors.lastname: Renzi
authors.forename: L A
authors.initials: LA
authors.lastname: De Luca Júnior
mesh_terms: D000315:Adrenalectomy; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000494:pharmacology; D000805:Angiotensin III / Q000494:pharmacology*; D000818:Animals; D003900:Desoxycorticosterone / Q000627:therapeutic use; D004231:Diuresis / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000378:metabolism
chemical_list: D000804:Angiotensin II; D000805:Angiotensin III; D003900:Desoxycorticosterone; D012965:Sodium Chloride; C014622:angiotensin II, Ile(8)-