[A lidocaine base for surface anesthesia of the tympanic membrane].
An anatomical study was conducted to determine the effects of 10% lidocain base (dissolved in DMSO) on the structure of the tympanic membrane. Survival times ranged from 1 day to 3 months. Membranes were embedded in plastic and cut in semithin sections. Within 1 and 3 days mild swelling of the epithelium was seen; 1 month after treatment the connective tissue layers of the lamina propria were severely hyperplastic. 2 months after lidocain-Base application additional collagen fibres, loosely packed and less regularly, appeared in the submucosal connective tissue layer. However, normal appearance of the drums was noticeable after 3 months survival.
Strutz
J
J
Univ.-HNO-Klinik Freiburg/Br.
Zöllner
C
C
D000772:Anesthesia, Local; D000818:Animals; D004848:Epithelium / Q000187:drug effects; D006168:Guinea Pigs; D008012:Lidocaine / Q000633:toxicity*; D014432:Tympanic Membrane / Q000187:drug effects*
D008012:Lidocaine
Lidocain-Base zur Oberflächenanästhesie des Trommelfells.