[Effect of adenosine on P50 and its relation to 2,3-diphosphoglycerate].
The effects of increasing doses of intravenous adenosine upon the dissociation haemoglobin curve (DHC) and its relation to the intraerythrocytic level of 2,3-diphosphoglyceric acid (2,3-DPG), were studied in 17 anesthetized dogs. The DHC moved significantly to the left in all dogs except at the dose of 120 micrograms/kg/min which induces a displacement to the right. These changes in the DHC were parallel to the intraerythrocytic levels of 2,3-DPG. We conclude that adenosine modifies the DHC, shifting it generally to the left, and that this effect seems to be related to a change in the intraerythrocytic level of 2,3-DPG.
Silva Orrego
P
P
Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.
Vicente Vera
T
T
Amador
F
F
Pastelín
G
G
D019794:2,3-Diphosphoglycerate; D000241:Adenosine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004285:Dogs; D004909:Erythrocyte Indices / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D007275:Injections, Intravenous; D008297:Male
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D019794:2,3-Diphosphoglycerate; D000241:Adenosine
Efecto de la adenosina sobre la P50 y su relación con el 2,3-difosfoglicerato.