Effects of intravenous L-acetylcarnitine on retinal oscillatory potentials.
L-acetylcarnitine is a compound with cholinergic properties and putative action on the visual system and the glucose metabolism. Ten healthy, emmertropic volunteers (age range: 21 to 28 years) were studied. Each subject was administered 5, 10, and 30 mg/kg acute intravenous doses of L-acetylcarnitine and matching placebo. Retinal oscillatory potentials to full-field flash stimulation were recorded before and 30, 60, and 120 min after administration. A systematic reduction of the implicit time of the P2 and N2 oscillatory potential components was observed after administration of the 10 and 30 mg/kg doses: significant changes were not evident at the 5 mg dose or after placebo. The latency reduction was significantly correlated with the postdrug increment of the L-acetylcarnitine plasma concentration. No other systematic modification in latency of amplitude was observed.
Sannita
W G
WG
Center for Neuropsychoactive Drugs, Institute of Neurophysiopathology, University, Stony Brook, N.Y.
Lopez
L
L
Maggi
L
L
Rosadini
G
G
D000108:Acetylcarnitine / Q000097:blood / Q000494:pharmacology*; D000328:Adult; D002331:Carnitine / Q000031:analogs & derivatives*; D004594:Electrophysiology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009991:Oscillometry; D012160:Retina / Q000187:drug effects; D014794:Visual Fields
D000108:Acetylcarnitine; D002331:Carnitine