[Inhibitory effect of CG-120 on the formation, growth and aggregation of calcium oxalate crystals in vitro].
The inhibitory effect of CG-120 on the formation, growth and aggregation of calcium oxalate (CaOx) crystals was estimated by the use of Coulter counter TA II in the whole urine system and seed crystal method. In the whole urine system, after determining the metastable limit, the formation and growth of calcium oxalate crystals precipitated in response to a load of sodium oxalate was measured. CG-120 had a strong inhibitory effect on the formation and growth above the concentration of 500 micrograms/ml. In the seeded crystal system, inhibitory activity of aggregation (Ia) and growth (Ig) were calculated from the change in the number and volume of crystals. Above 250 micrograms/ml, CG-120 inhibited the aggregation and growth of added CaOx monohydrate and dihydrate crystals. CG-120 therefore might be useful for treating the recurrent stone formers.
Suzuki
K
K
Department of Urology, Kanazawa Medical University.
Tsugawa
R
R
D002129:Calcium Oxalate / Q000652:urine*; D002951:Citrates / Q000494:pharmacology* / Q000627:therapeutic use; D019343:Citric Acid; D003460:Crystallization; D006801:Humans; D066298:In Vitro Techniques; D014545:Urinary Calculi / Q000188:drug therapy
D002951:Citrates; D002129:Calcium Oxalate; D019343:Citric Acid