[Effect of age on the activity of hepatic mixed function oxidases in female rats].
Female Wistar rats aged 5, 10, 15, 30, 60 and 540 days were tested. The rough and smooth microsomes fraction of the liver were tested for protein, cytochromes P-450 and b5 contents as well as for NADPH-cytochrome c reductase, NADH-cytochrome b5 reductase and two monooxygenases activity. Cytochrome P-450 and b5 contents and NADH-cytochrome b5 reductase activity were increasing up to the age of 60 but aniline hydroxylase--up to the age of 15 days. NADPH-cytochrome c reductase activity exhibited a gradual decreasing trend with age. In senescent animals (540 days) the contents of cytochromes and monooxygenases activity were lower but NADPH-cytochrome c reductase activity was higher, as compared to young rats.
Plewka
D
D
II Katedry Histologii i Embriologii Sl. AM w Katowicach.
Plewka
A
A
Kamiński
M
M
Gaździk
T
T
D000375:Aging / Q000378:metabolism*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003579:Cytochrome Reductases / Q000378:metabolism*; D003573:Cytochrome b Group / Q000378:metabolism*; D015786:Cytochromes b5; D005260:Female; D008862:Microsomes, Liver / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D003573:Cytochrome b Group; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D003579:Cytochrome Reductases
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