The effect of diphenylhydantoin on spreading depression.
The present study examines the effect of diphenylhydantoin on the elicitation by K+ and propagation of spreading depression in chick retina preparations in vitro. A dose-related decrease in the velocity of propagation was observed, this effect being lessened by increasing the pH of the Ringer bathing the preparation. Changes in Ringer Cl- concentration also altered the efficacy of the drug, higher concentrations enhancing and lower concentrations reducing efficacy. The threshold concentration of K+ necessary to elicit the reaction was elevated by diphenylhydantoin.
Chebabo
S R
SR
Departamento de Neurobiologia, Universidade Federal do Rio de Janeiro, Brasil.
Do-Carmo
R J
RJ
Martins-Ferreira
H
H
D000818:Animals; D002645:Chickens; D013181:Cortical Spreading Depression / Q000187:drug effects*; D007552:Isotonic Solutions; D010672:Phenytoin / Q000494:pharmacology*; D010857:Pigment Epithelium of Eye / Q000378:metabolism; D011188:Potassium / Q000378:metabolism*; D012160:Retina / Q000378:metabolism*; D000077331:Ringer's Solution
D007552:Isotonic Solutions; D010672:Phenytoin; D000077331:Ringer's Solution; D011188:Potassium