Lack of impairment of fluocortolone disposition in oral contraceptive users.
Seven healthy women chronically (greater than 6 months) treated with oral contraceptives and 7 age- and weight-matched female controls were studied. Each subject was given 20 mg fluocortolone orally and the plasma concentrations of total and unbound fluocortolone in multiple samples obtained during the following 24 h were determined by HPLC and equilibrium dialysis. In the subjects on oral contraceptives there was no significant change in total clearance, unbound clearance or volume of distribution at steady-state of total and unbound fluocortolone, but there was a significant increase in hydrocortisone concentration compared to the control subjects. It appears that the elimination of the synthetic corticoid fluocortolone was not impaired by chronic administration of contraceptive steroids.
Legler
U F
UF
Department of Internal Medicine, RWTH Aachen, Federal Republic of Germany.
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D005448:Fluocortolone / Q000493:pharmacokinetics*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood
D003278:Contraceptives, Oral, Hormonal; D005448:Fluocortolone; D006854:Hydrocortisone