title: [The effect of a combination of ampicillin and sulbactam against clinical anaerobic isolates].
abstract: Effect of a Combination of Ampicillin and Sulbactam on Clinical Isolates of Anaerobic Bacteria. The antimicrobial susceptibility of 182 recent clinical isolates of anaerobic bacteria to ampicillin alone, ampicillin plus 1 mg/l sulbactam, ampicillin plus 5 mg/l sulbactam, and cefoxitin was studied by means of agar dilution tests. The ampicillin-sulbactam combination (Unacid) was most effective against species of the Bacteroides fragilis group, the MIC90 of ampicillin plus 5 mg/l sulbactam for B. fragilis being less than or equal to 1 mg/l, compared to 256 mg/l of ampicillin, 4 mg/l of ampicillin plus 1 mg/l sulbactam, and 8 mg/l of cefoxitin. No significant difference between ampicillin alone and in combination with sulbactam was observed against gram-positive anaerobic rods or cocci.
authors.affiliation: Abteilung Medizinische Mikrobiologie, Hygiene-Institut der Universität, Tübingen.
authors.forename: H
authors.initials: H
authors.lastname: Werner
authors.forename: W
authors.initials: W
authors.lastname: Heizmann
authors.forename: F
authors.initials: F
authors.lastname: Heilmann
mesh_terms: D000667:Ampicillin / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001439:Bacteroides / Q000187:drug effects; D003013:Clostridium / Q000187:drug effects; D004338:Drug Combinations; D013407:Sulbactam / Q000494:pharmacology*
chemical_list: D004338:Drug Combinations; D000667:Ampicillin; D013407:Sulbactam
vernacular_title: Wirkung einer Kombination aus Ampicillin und Sulbactam gegen klinische Anaerobier-Isolate.