Short-term toxicity study of allyl isothiocyanate in rats.
Allyl isothiocyanate (AITC) was given in doses of 0, 10, 20, or 40 mg/kg (5 days/week) by oral intubation to male rats for up to 6 weeks. The highest dosage level caused a decrease in body weight, thymus weight, blood glucose and serum globulin levels. Haematological examination revealed an increased percentage of neutrophils and a decreased percentage of lymphocytes after treatment for 2 weeks. Increased liver and adrenal weights were found in all test groups. Renal dysfunction was indicated by increased urinary aspartate amino-transferase activity, reduced urine volume and changes in the specific gravity of the urine. Histopathological changes were observed in the kidneys of animals at dosages of 20 and 40 mg/kg and in the livers of animals at the highest dosage level.
Lewerenz
H J
HJ
Central Institute of Nutrition in Potsdam-Rehbrücke, Academy of Sciences of the GDR.
Plass
R
R
Bleyl
D W
DW
Macholz
R
R
D000818:Animals; D001772:Blood Cell Count; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D005520:Food Preservatives / Q000633:toxicity*; D017879:Isothiocyanates; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012712:Serum Globulins / Q000378:metabolism; D013861:Thiocyanates / Q000633:toxicity*
D001786:Blood Glucose; D005520:Food Preservatives; D017879:Isothiocyanates; D012712:Serum Globulins; D013861:Thiocyanates; C004471:allyl isothiocyanate