title: [Determination of immune complexes in the serum of pregnant patients and puerperal females with EPH gestosis].
abstract: We analyzed the blood sera from 100 patients with EPH gestosis and from 50 women with normal pregnancy to explore the immunological reactions during gestosis. The sera of cord blood were included in the investigations. We determined the circulating immune complexes by conglutinin and C1q solid phase radioimmunoassay and by polyethyleneglycol precipitation. It has been established by conglutinin RIA that during pregnancy the women with gestosis have significant higher concentrations of immune complexes than the control group. During puerperium and in the cord blood the values are significantly lower than during pregnancy in both groups. The estimations of immune complexes by C1q RIA have shown that the differences between the two groups are insignificant and the lowest values are in the cord blood. The concentrations of immune complexes estimated by PEG precipitation were not significantly different between the two groups. It is concluded that immune complexes are in connection with the pathogenesis of preeclampsia.
authors.affiliation: Klinik für Gynäkologie und Geburtshilfe der Medizinischen Akademie Magdeburg.
authors.forename: P
authors.initials: P
authors.lastname: Wagler
authors.forename: H
authors.initials: H
authors.lastname: Donat
authors.forename: H
authors.initials: H
authors.lastname: Struy
authors.forename: J
authors.initials: J
authors.lastname: Morenz
mesh_terms: D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008431:Maternal-Fetal Exchange; D049590:Postpartum Period / Q000276:immunology*; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy; D011863:Radioimmunoassay
chemical_list: D000936:Antigen-Antibody Complex
vernacular_title: Bestimmung von Immunkomplexen im Serum von Schwangeren und Wöchnerinnen mit EPH-Gestose.