title: Acute effects of peritoneovenous shunt (Le Veen) on the hemodynamics and gas exchange in patients with hepatic intractable ascites.
abstract: The acute effects of the peritoneovenous shunt (LeVeen) on hemodynamics and pulmonary gas exchange in 6 consecutive patients with intractable ascites and cirrhosis were evaluated. After opening the peritoneovenous shunt, there was a marked increase in cardiac index, (from 3.78 +/- 0.4 to 5.86 +/- 0.4 1/min. m2, p less than 0.01), and mean pulmonary artery pressure (from 17.3 +/- 1.9 to 23.3 +/- 1.5 mmHg, p less than 0.05), while a significant decrease in systemic vascular resistances (from 1086 +/- 116 to 694 +/- 52 dynes.sec.cm-5, p less than 0.05) was observed. In all patients there was a drop in arterial oxygen tension (PaO2) (from 76 +/- 3 to 67 +/- 3 torr, p less than 0.01) and an increase in venous admixture (Qsp/Qt) from 13.1 +/- 2 to 18.9 +/- 2%, p less than 0.01). The comparable increase in cardiac output and in venous admixture produced by opening the peritoneovenous shunt, might be related to the massive transfusion of ascitic fluid into the intravascular compartment. It is therefore concluded that this impairment of tas exchange further support discarding an appropriate amount of ascitic fluid at the time of shunt insertion.
authors.affiliation: Istituto di Clinica Chirurgica, Unità di Terapia Intensiva, Università di Pisa.
authors.forename: L S
authors.initials: LS
authors.lastname: Brandi
authors.forename: M
authors.initials: M
authors.lastname: Grana
authors.forename: F
authors.initials: F
authors.lastname: D'Elia
authors.forename: M
authors.initials: M
authors.lastname: Ferrari
authors.forename: M
authors.initials: M
authors.lastname: Oleggini
authors.forename: M
authors.initials: M
authors.lastname: Carmellini
authors.forename: A
authors.initials: A
authors.lastname: Pietrabissa
authors.forename: F
authors.initials: F
authors.lastname: Mosca
mesh_terms: D000368:Aged; D001201:Ascites / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008103:Liver Cirrhosis / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010536:Peritoneovenous Shunt; D011659:Pulmonary Gas Exchange