Hepatic drug disposition in multiple organ failure.
In 15 patients with multiple organ failure of septic etiology, some principal partial hepatic functions of drug disposition were measured by the test substances galactose, indocyanine green, theophylline and 4-methylumbelliferon. Glucuronidation was not impaired in any case, whereas flow-limited and capacity-limited drug elimination can be influenced. Drug monitoring and intense clinical observation seem necessary to improve drug therapy and the outcome of patients with multiple organ failure.
Schregel
W
W
Department of Anesthesiology and Intensive Care Medicine, Knappschaftskrankenhaus, Ruhr-Uni-Bochum, W. Germany.
Kuntz
H D
HD
Vitt
M
M
D000328:Adult; D000368:Aged; D005260:Female; D005690:Galactose; D006801:Humans; D006923:Hymecromone; D007208:Indocyanine Green; D008099:Liver / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000378:metabolism* / Q000503:physiopathology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D013806:Theophylline
D004364:Pharmaceutical Preparations; D006923:Hymecromone; D013806:Theophylline; D007208:Indocyanine Green; D005690:Galactose