Endogenous L-dopa, its immunoreactivity in neurons of midbrain and its projection fields in the cat.
L-DOPA (L-3,4-dihydroxyphenylalanine) immunoreactivity was demonstrated in neurons of the cat ventral midbrain and its projection areas, using an immunohistochemical method in conjunction with a newly developed highly specific anti-L-DOPA serum. L-DOPA-immunoreactive (IR) neurons were found in the substantia nigra, retrorubral area and ventral tegmental area of Tsai. L-DOPA-labeled fibers and terminals were hardly detectable in the nigrostriatal pathway and in the caudate nucleus which showed very intense dopamine-immunoreactivity. In contrast, many short labeled processes were detectable in the central amygdala and, although very few in number, in the entorhinal cortex.
Kitahama
K
K
Département de Médecine Expérimentale, C.N.R.S. UA1195, INSERM U52, Faculté de Médecine, Université Claude Bernard, Lyon, France.
Mons
N
N
Okamura
H
H
Jouvet
M
M
Geffard
M
M
D000818:Animals; D001931:Brain Mapping; D002415:Cats; D007150:Immunohistochemistry; D007980:Levodopa / Q000378:metabolism*; D008636:Mesencephalon / Q000166:cytology / Q000378:metabolism*; D012012:Red Nucleus / Q000166:cytology / Q000378:metabolism; D013378:Substantia Nigra / Q000166:cytology / Q000378:metabolism; D013681:Tegmentum Mesencephali / Q000166:cytology / Q000378:metabolism
D007980:Levodopa