[The effectiveness of the combined treatment of thrombocytic hemorrhagic diathesis of dogs with prednisolone and blood transfusion in the model of an aspirin-produced thrombocytopathy].
The administration of 20 mg/kg of acetylsalicylic acid in 18 clinically healthy dogs resulted in a thrombocytopathy with lengthened capillary bleeding time and irreversible aggregation inhibition. Through the set up of individual dilution series, one could conclude the proportional percentage of aggregation functional transfused thrombocytes. The capillary bleeding time was shortened after the intravenous injection of prednisolone (5 mg/kg) without measurable influence on the thrombocytes. Compared to the singular use of cortisone or blood transfusion alone, the effect on capillary bleeding time became magnified when one combined transfusion and corticosteroids. The fresh blood conserves (12 hours) were, with respect to the haemostyptical properties, superior to blood stored for 5 days. The component of aggregation-functional thrombocytes was, due to the prophylactic cortisone application prior to transfusion, not increased.
Nolte
I
I
Medizinischen und Gerichtlichen Veterinärklinik I, Justus-Liebig-Universität Giessen.
Niemann
C
C
Failing
K
K
Müller-Berghaus
G
G
D000818:Animals; D001241:Aspirin / Q000009:adverse effects; D001760:Bleeding Time / Q000662:veterinary; D001791:Blood Platelet Disorders / Q000139:chemically induced / Q000628:therapy / Q000662:veterinary*; D001793:Blood Preservation; D001803:Blood Transfusion / Q000662:veterinary*; D003131:Combined Modality Therapy / Q000662:veterinary; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000139:chemically induced / Q000628:therapy*; D004285:Dogs; D005260:Female; D006474:Hemorrhagic Disorders / Q000628:therapy / Q000662:veterinary*; D010974:Platelet Aggregation; D010976:Platelet Count / Q000662:veterinary; D011239:Prednisolone / Q000627:therapeutic use*
D011239:Prednisolone; D001241:Aspirin
Untersuchung zur Wirksamkeit der kombinierten Behandlung thrombozytärer hämorrhagischer Diathesen des Hundes mit Prednisolon und Bluttransfusion am Beispiel einer durch Aspirin hervorgerufenen Thrombozytopathie.