Inhibitory effect of cilazaprilat on norepinephrine release induced by renal nerve stimulation in anesthetized dogs.
In pentobarbital-anesthetized dogs, the increase in the renal norepinephrine secretion rate elicited by renal nerve stimulation (1 Hz) during infusion of angiotensin I (15 ng/kg/min) was partially but significantly inhibited (by 21-37%) after dosing with cilazaprilat (0.1 mg/kg), an angiotensin converting enzyme inhibitor, accompanied by a decrease in the renal venous plasma norepinephrine concentration. These results may suggest that cilazaprilat exerts at least a part of its hypotensive effect through decreasing the facilitatory action of endogenous angiotensin II on adrenergic transmission.
Satoh
S
S
Department of Pharmacology, Tohoku University, Sendai, Japan.
Matsuoka
T
T
Suzuki-Kusaba
M
M
Chiba
K
K
D000803:Angiotensin I / Q000494:pharmacology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D017315:Cilazapril / Q000031:analogs & derivatives*; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D011724:Pyridazines / Q000494:pharmacology*
D000806:Angiotensin-Converting Enzyme Inhibitors; D011724:Pyridazines; D017315:Cilazapril; D000803:Angiotensin I; C045980:cilazaprilat; D009638:Norepinephrine