[Gaba-activated conductance of isolated neurons of rat cerebellum and sensory ganglia].
Results of the study of GABA-activated ion currents on single isolated neurons of rat were obtained by means of voltage-clamp, intracellular perfusion and "concentration clamp" methods. The reversion potential of GABA-activated current corresponded to the equilibrium potential for Cl ions as it was determined by the Nernst equation. The dose-response relationship was activated by a single GABA molecule (Kd = 1.4.10(-4) mol/l). GABA-activated currents were blocked by bicuculline methoiodide and isocoryne.
Valeev
A E
AE
Chernevskaia
N I
NI
D000818:Animals; D001640:Bicuculline / Q000031:analogs & derivatives / Q000494:pharmacology; D002531:Cerebellum / Q000502:physiology*; D004594:Electrophysiology; D018756:GABA Antagonists; D005724:Ganglia / Q000503:physiopathology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D018756:GABA Antagonists; C017069:bicuculline methiodide; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline
GAMK-aktiviruemaia provodimost' izolirovannykh neĭronov mozzhechka i sensornykh gangliev krys.