[How sensitive and specific is the determination of gliadin antibodies in the serum of patients with severe damage of small intestine mucosa?].
Serum antigliadin antibodies of the IgG- and IgA-class were investigated by an ELISA-test in healthy children, children suffering from coeliac disease and children with recurrent diarrheas. The sensitivity and specificity of positive antibody-titres for the diagnosis of coeliac disease were evaluated. The investigation of antigliadin antibodies proved to be a useful instrument for the diagnosis of acute coeliac disease as well as for the follow-up of such patients. The limitations of this method are pointed out.
Hebel
E
E
Abteilung Allgemeine Pädiatrie, Universitäts-Kinderklinik Giessen.
Piske-Keyser
K
K
Otten
A
A
Wolf
H
H
D000293:Adolescent; D000906:Antibodies / Q000032:analysis*; D001706:Biopsy; D002446:Celiac Disease / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D007413:Intestinal Mucosa / Q000473:pathology*; D007421:Intestine, Small / Q000473:pathology; D010940:Plant Proteins / Q000276:immunology*
D000906:Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D010940:Plant Proteins; D005903:Gliadin
Wie sensibel und spezifisch ist die Bestimmung von Gliadin-Antikörpern im Serum bei Patienten mit schwerer Dünndarmschleimhautschädigung?