title: Theoretical and methodological bases of experimental simulation of the prepathological state under membrane-damaging effects of environmental factors.
abstract: The paper theoretically substantiates the importance for detecting the prepathological state of experimental simulation of those situations in the organism which adequately reflect changes in human metabolism exposed to multiple environmental factors. A putative experimental model has been proposed in the shape of sexually immature and mature generations of animals of differing age with a "metabolic burden" whose characteristics, as regards impairments in biochemical, immunological and other functional reactions in biological fluids, are to some extent similar to those occurring in certain groups of humans. It has been suggested that the further investigation of the mechanisms and biological significance of systemic changes of the body's internal milieu may hold promise for studies of environmental hygiene in evaluating populational health and detecting the early signs of metabolic alterations with the aim of their timely prevention.
authors.affiliation: Department of Medico-Biological Research, A. N. Sysin Research Institute of General and Communal Hygiene, USSR Academy of Medical Sciences, Moscow.
authors.forename: G I
authors.initials: GI
authors.lastname: Sidorenko
authors.forename: R V
authors.initials: RV
authors.lastname: Merkurieva
mesh_terms: D000118:Acetylglucosaminidase / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001822:Body Burden; D005314:Embryonic and Fetal Development / Q000187:drug effects; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D005557:Formaldehyde / Q000633:toxicity*; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008566:Membranes / Q000187:drug effects; D008660:Metabolism / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012794:Sialic Acids / Q000097:blood
chemical_list: D004785:Environmental Pollutants; D012794:Sialic Acids; D005557:Formaldehyde; D005969:Glutamate Dehydrogenase; D000118:Acetylglucosaminidase