title: The frequency of brain lesions in alcoholics. Comparison between the 5-year periods 1975-1979 and 1983-1987.
abstract: This is a follow-up study of a previous investigation of brain lesions in alcoholics during the 5-year period from 1975 through 1979 (Torvik et al. 1982). The autopsy material from the 5-year period 1983-1987 was examined in order to see whether improved clinical treatment had resulted in a reduced frequency of alcohol-related brain lesions, particularly of active Wernicke's encephalopathy. The percentage of alcoholics (8.2 vs. 8.7%), the male/female ratio (4.2/1) and their mean age (60.4 vs. 62.2 years) were similar in the two recording periods, as was the frequency of alcoholic cerebellar atrophy (26.8 vs. 27.6%). In both periods the brain weight in male alcoholics aged 40-70 years was significantly lower than in age-matched controls. This difference was not present after 70 years of age. The most important finding was a considerable but not significant reduction of the frequency of active and inactive Wernicke's encephalopathy in alcoholics. Review of the clinical records supports the hypothesis that this reduction reflects better diagnostic and therapeutic procedures in the clinical departments. However, even during the last period most cases of active Wernicke's encephalopathy were not recognized clinically and further improvement of the clinical management should therefore be possible.
authors.affiliation: Department of Pathology, Ullevål Hospital, Oslo, Norway.
authors.forename: C F
authors.initials: CF
authors.lastname: Lindboe
authors.forename: E M
authors.initials: EM
authors.lastname: Løberg
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications / Q000473:pathology*; D002526:Cerebellar Diseases / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D014899:Wernicke Encephalopathy / Q000209:etiology / Q000473:pathology*