title: MFO activity changes in single living 3T3 fibroblasts treated with adriamycin.
abstract: The effects of Adriamycin on 3T3 fibroblasts has been followed by microspectrofluorimetry. MFO activity was monitored by BaP metabolism and three points were studied: long-term ADR treatment, reversibility of this treatment and cysteamine effect on ADR treatment. The appearance of a sub-population that does not accumulate BaP suggests either a greater efflux of BaP or no penetration of the compound after ADR treatment. Moreover drastic morphological changes were observed.
authors.affiliation: Laboratorie de Chimie Physique, Université de Perpignan, France.
authors.forename: S
authors.initials: S
authors.lastname: Lahmy
authors.forename: J M
authors.initials: JM
authors.lastname: Salmon
authors.forename: P
authors.initials: P
authors.lastname: Viallet
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002478:Cells, Cultured; D003543:Cysteamine / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D007700:Kinetics; D051379:Mice; D006899:Mixed Function Oxygenases / Q000378:metabolism*
chemical_list: D003543:Cysteamine; D004317:Doxorubicin; D006899:Mixed Function Oxygenases