Can deferoxamine be considered an ototoxic drug?
Some uncertainty about deferoxamine ototoxicity is to be found in the literature. Therefore, 100 patients affected by beta-thalassemia were checked audiologically. Twelve of them showed a sensorineural hearing impairment which in most cases was confined to 4 and 8 kHz. If these results are compared with a sample of "normal" population, no significant difference can be observed, therefore excluding that deferoxamine, at least at present dosages, may be considered as a certain cause of cochlear impairment.
Masala
W
W
ENT Clinic, University of Sassari, Italy.
Meloni
F
F
Gallisai
D
D
Careddu
M
M
Secchi
G
G
Cuccuru
G B
GB
Loriga
V
V
Salvo
G
G
D000293:Adolescent; D000328:Adult; D002648:Child; D003676:Deferoxamine / Q000009:adverse effects* / Q000627:therapeutic use; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D013789:Thalassemia / Q000628:therapy*
D003676:Deferoxamine