[Induction by an inactivated influenza virus of congenital pathology and pregnancy pathology in mice].
Intravenous inoculation of pregnant mice with inactivated (noninfectious) influenza virus reduces by one-third their fertility owing to the death of the fetuses. Among the progeny of such females, there are specimens with signs of progressive pathology clinically similar to that which develops in the progeny born to the females intranasally inoculated during pregnancy with a live (infectious) influenza virus. The frequency of such pathology depends both on the virus strain and on genetic characteristics of mice. The role of influenza virus surface structures in the development of pathology of pregnancy and pathology in the progeny is discussed.
Morozova
E L
EL
Zuev
V A
VA
Kharitonova
A M
AM
D000818:Animals; D005260:Female; D005313:Fetal Death / Q000209:etiology / Q000382:microbiology; D006389:Hemagglutinins, Viral / Q000032:analysis; D009980:Influenza A virus / Q000276:immunology / Q000472:pathogenicity* / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009439:Neuraminidase / Q000032:analysis; D009976:Orthomyxoviridae Infections / Q000151:congenital / Q000209:etiology* / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000209:etiology* / Q000382:microbiology
D006389:Hemagglutinins, Viral; D009439:Neuraminidase
Induktsiia inaktivirovannym virusom grippa vrozhdennoĭ patologii i patologii beremennosti u mysheĭ.