Synaptonemal complex damage as a measure of genotoxicity at meiosis.
Synaptonemal complex aberrations can provide a sensitive measure of chemical-specific alterations to meiotic chromosomes. Mitomycin C, cyclophosphamide, amsacrine, ellipticine, colchicine, vinblastine sulfate, and cis-platin exposures in mice have been shown to cause various patterns of synaptonemal complex structural damage and synaptic irregularity. These effects are suggestive of abnormal homologue pairing/synapsis/recombination effects which, theoretically, could be implicated in mechanisms leading to aneuploidy and other potentially heritable chromosomal disorders.
Allen
J W
JW
Genetic Toxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.
Poorman
P A
PA
Backer
L C
LC
Gibson
J B
JB
Westbrook-Collins
B
B
Moses
M J
MJ
D000470:Alkaloids / Q000633:toxicity; D000818:Animals; D002945:Cisplatin / Q000633:toxicity; D003520:Cyclophosphamide / Q000633:toxicity; D008297:Male; D008540:Meiosis / Q000187:drug effects*; D051379:Mice; D008937:Mitomycins / Q000633:toxicity; D009152:Mutagenicity Tests; D013573:Synaptonemal Complex / Q000187:drug effects*
D000470:Alkaloids; D008937:Mitomycins; D003520:Cyclophosphamide; D002945:Cisplatin