title: [Substrate specificity of adenosine deaminase. The role of methyl groups at 2', 3', and 5'-carbon atoms of adenosine].
abstract: The substrate specifity of adenosine deaminase has been studied using C'-methyl derivatives of adenosine. On the basis of the correlation revealed between conformations of 2'- and 3'-C-methyladenosine and their substrate properties, a modified stereochemical model is suggested: the enzyme accepts the substrate within a N-type conformational range (4E----4T3----3E) of the furanose ring. The model was analysed in details using a number of C3'-modified adenosines and 5'-C-methyladenosine analogues with D-allo- and L-talo-configuration.
authors.forename: E N
authors.initials: EN
authors.lastname: Kalinichenko
authors.forename: L N
authors.initials: LN
authors.lastname: Beĭgel'man
authors.forename: S N
authors.initials: SN
authors.lastname: Mikhaĭlov
authors.forename: I A
authors.initials: IA
authors.lastname: Mikhaĭlopulo
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D007700:Kinetics; D009700:Nucleoside Deaminases / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: C024341:2'-O-methyladenosine; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase; D000241:Adenosine
vernacular_title: Substratnaia spetsifichnost' adenozindezaminidazy. Rol' metil'nykh grupp pri 2', 3' i 5'-atomakh ugleroda adenozina.