Safety evaluation studies of SGF gum--a potential food additive from the seed of Sesbania cannabina.
SGF gum, derived from the plant Sesbania cannabina, has properties very similar to those of guar gum. Because it is much cheaper than guar, SGF gum is of interest as a possible new food additive. It has therefore been tested in rats for acute, short-term and subchronic toxicity, teratogenicity and effects on reproductive performance, and a 1% concentration in the diet has been identified as the no-effect level. The tests complied with the guidelines issued by the Chinese authorities. Mutagenicity studies, Ames tests and a micronucleus test gave negative results, and a dominant lethal test in mice was negative at the 1% dietary level, although at 5 and 10% the results were equivocal. No adverse changes were elicited in 23 human volunteers who consumed a total of 960 mg SGF gum during a 30-day period during which they consumed, daily, 80 g ice-cream containing 0.04% SGF gum instead of the usual thickener. On the basis of applying a 100-fold safety factor to the findings in the animal studies, an acceptable human daily intake of 6 mg/kg is suggested.
Li
X L
XL
Department of Public Health, Tianjin Medical College, People's Republic of China.
Xu
E Y
EY
Xu
G C
GC
Shang
R M
RM
Wang
Y M
YM
Chen
J
J
Huang
F C
FC
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000328:Adult; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005503:Food Additives / Q000633:toxicity*; D005685:Galactans / Q000633:toxicity*; D006801:Humans; D008297:Male; D008351:Mannans / Q000633:toxicity*; D008875:Middle Aged; D009153:Mutagens; D009929:Organ Size / Q000187:drug effects; D053149:Plant Gums; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects
D005503:Food Additives; D005685:Galactans; D008351:Mannans; D009153:Mutagens; D053149:Plant Gums; C058260:SGF gum