Characterization of morphine's excitatory effects.
Although the excitatory effects of opiates have assumed greater importance in theories of compulsive drug use, the nature and time course of these effects remains unclear. The authors attempted to characterize the excitatory effects of morphine by administering doses of 5 mg/kg and 20 mg/kg in both warm and cold environments and by undertaking simultaneous assessments of core temperature, locomotor activity, and oxygen consumption. The results argue for a two receptor model to account for morphine's thermic effects: a high-affinity receptor that activates thermogenic systems, and a low-affinity receptor that mediates a poikilothermic response.
Jorenby
D E
DE
Department of Psychology, University of Wisconsin, Madison 53706.
Keesey
R E
RE
Baker
T B
TB
D000818:Animals; D001143:Arousal / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects; D005059:Euphoria / Q000187:drug effects*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D009020:Morphine