title: [Effect of lincomycin and staphylococcal vaccine on the course of experimental staphylococcal sepsis].
abstract: Therapeutic efficacy of lincomycin used alone and in combination with inactivated staphylococcal vaccine and the effect of these agents on synthesis of antibodies and their content in blood serum were investigated. Lincomycin was shown to inhibit septic processes in the host. After its administration the number of the pathogens in the blood and organs markedly decreased. At the same time, lincomycin lowered antibody synthesis in the lymphoid organs and the content of alpha-antitoxins in blood serum. The use of lincomycin in combination with inactivated staphylococcal vaccine promoted an increase in the number of the antibody forming cells in the spleen and lymph nodes and the content of the antibodies to the staphylococcal alpha-toxin in blood serum of the animals with staphylococcal sepsis.
authors.forename: L S
authors.initials: LS
authors.lastname: Gabysehva
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Tsyganenko
authors.forename: N N
authors.initials: NN
authors.lastname: Piten'ko
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D003131:Combined Modality Therapy; D008034:Lincomycin / Q000627:therapeutic use*; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D013154:Spleen / Q000276:immunology; D013203:Staphylococcal Infections / Q000628:therapy*; D013209:Staphylococcal Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D013209:Staphylococcal Vaccines; D015164:Vaccines, Inactivated; D008034:Lincomycin
vernacular_title: Vliianie linkomitsina i stafilokokkovoĭ vaktsiny na techenie éksperimental'nogo stafilokokkovogo sepsisa.