Variation in DNA content of mononuclear cells of patients with dementia of the Alzheimer type.
Flow cytometry studies to measure mean DNA content and intercellular variability around the mean were performed on mononuclear blood cells obtained from 21 patients with a clinical diagnosis of dementia of the Alzheimer type (DAT) and 25 cognitively intact individuals. There was no difference in the mean DNA content between both groups. However, patients with DAT had significantly increased intercellular variability compared to controls (3.52 vs. 3.06, respectively). These results are consistent with the reports of increased aneuploidy associated with DAT found on cytogenetic examination.
Matsuyama
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West Los Angeles VA Medical Center, Brentwood Division, CA.
Bohman
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D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D004247:DNA / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000032:analysis*; D008297:Male; D008875:Middle Aged
D004247:DNA