Studies on cytotoxic constituents in pericarps of Mallotus japonicus, Part III.
Two new cytotoxic chromene derivatives, butyrylmallotochromene [10] and isobutyrylmallotochromene [11], were isolated from the pericarps of Mallotus japonicus. The new derivatives were identified as 5,7-dihydroxy-6-(2',4'-dihydroxy-3'-acetyl-5'-methyl-6'-methoxybenzyl)-8 - butyryl-2,2-dimethylchromene [10] and 5,7-dihydroxy-6-(2',4'-dihydroxy-3'-acetyl-5'-methyl-6'-methoxybenzyl)-8 - isobutyryl-2,2-dimethylchromene [11] by means of spectral data. These compounds and their respective acetylation and methylation products were found to be cytotoxic against KB cell lines.
Fujita
A
A
Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Hayashi
T
T
Arisawa
M
M
Shimizu
M
M
Morita
N
N
Kikuchi
T
T
Tezuka
Y
Y
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000633:toxicity*; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000032:analysis*
D000972:Antineoplastic Agents, Phytogenic