Reversal by caffeine of triazolam-induced impairment of waking function.
Twelve, healthy normal men aged 21-25 years received each of four treatments (triazolam placebo plus caffeine placebo, triazolam 0.50 mg plus caffeine placebo, triazolam 0.50 mg plus caffeine 4 mg/kg, triazolam 0.50 mg plus caffeine 8 mg/kg), double blind, in a Latin-Square design. Triazolam or placebo was administered at 0830 and caffeine or placebo at 1000 and 1245. On two memory tasks, administered at 1015 with an immediate recall and a delayed recall at 1230 following a 90 min nap (1030-1200), both immediate and delayed recall was impaired by triazolam. Neither caffeine dose reversed the impairments. Sleep latency and sleep efficiency were improved by triazolam and not reversed by caffeine. On a performance battery presented at 1300 most measures of performance were impaired by triazolam; in general the caffeine dose of 4 mg/kg partially reversed the effect while the dose of 8 mg/kg completely restored performance.
Roehrs
T
T
Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, MI 48202.
Zwyghuizen-Doorenbos
A
A
Smith
D
D
Zorick
F
F
Roth
T
T
D000328:Adult; D001143:Arousal / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology*; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008568:Memory / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D014229:Triazolam / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D014851:Wakefulness / Q000187:drug effects*
D006993:Hypnotics and Sedatives; D014229:Triazolam; D002110:Caffeine