Further evidence for a parathyroid hormone-related protein in fetal parathyroid glands of sheep.
Extracts of ovine fetal parathyroid glands contained a substance in addition to parathyroid hormone (PTH) which could not be neutralized by antiserum against PTH in a cytochemical bioassay. This substance reacted similarly to human parathyroid hormone-related protein, the humoral hypercalcaemic factor associated with malignancy in man. The ovine fetal PTHrP may be responsible for maintaining the fetus hypercalcaemic relative to the mother.
Loveridge
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Rowett Research Institute, Bucksburn, Aberdeen.
Caple
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IW
Rodda
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Martin
T J
TJ
Care
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D000818:Animals; D001681:Biological Assay; D005333:Fetus; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D007106:Immune Sera; D007686:Kidney Tubules, Distal / Q000187:drug effects / Q000201:enzymology; D010280:Parathyroid Glands / Q000032:analysis* / Q000196:embryology; D010281:Parathyroid Hormone / Q000032:analysis* / Q000494:pharmacology; D012756:Sheep
D007106:Immune Sera; D010281:Parathyroid Hormone; D005954:Glucosephosphate Dehydrogenase