Intracarotidal administration of liposomally-entrapped ATP: improved efficiency against experimental brain ischemia.
ATP entrapped into liposomes was administered intracarotidally to rats submitted to brain ischemics episodes by clamping of the carotid arteries and lowering of the systemic blood pressure. It was observed that when entrapped into liposomes, ATP greatly increased the number of ischemic episodes tolerated before brain electrical silence and death appeared. These results added to very similar previous data obtained by i.c.v. treatment excluding the prominent role of cardiovascular effects, could open new possibilities in brain antihypoxic protection. Here and now it cannot be stated if ATP provides direct energetic supply.
Laham
A
A
Laboratoire de Pharmacie Galénique et de Biopharmacie, UA CNRS 1218, Université de Paris XI.
Claperon
N
N
Durussel
J J
JJ
Fattal
E
E
Delattre
J
J
Puisieux
F
F
Couvreur
P
P
Rossignol
P
P
D000255:Adenosine Triphosphate / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002545:Brain Ischemia / Q000188:drug therapy*; D002339:Carotid Arteries; D004569:Electroencephalography; D007269:Injections, Intra-Arterial; D008081:Liposomes; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D008081:Liposomes; D000255:Adenosine Triphosphate