Is peptide T, an octapeptide sequence found in the external glycoprotein coat of the human immunodeficiency virus (HIV), a fragment of a retro-copy of the gamma-3-MSH neuropeptide?
It is proposed that peptide T, a protein sequence found in the HIV coat, shares homology with the carboxyl-terminal extension of the gamma-3-MSH neuropeptide. Based on this observation, it is hypothesized that the N-terminal gamma-MSH sequence is probably present in the glycoprotein coat. It is concluded that many of the symptoms caused by HIV are mediated by the gamma-MSH receptor.
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D000595:Amino Acid Sequence; D002213:Capsid / Q000378:metabolism; D006678:HIV / Q000378:metabolism*; D006801:Humans; D009074:Melanocyte-Stimulating Hormones / Q000031:analogs & derivatives* / Q000378:metabolism; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D015717:Peptide T; D011333:Pro-Opiomelanocortin / Q000378:metabolism; D011979:Receptors, Pituitary Hormone / Q000378:metabolism*
D009842:Oligopeptides; D010446:Peptide Fragments; D011979:Receptors, Pituitary Hormone; C028182:proopiocortin fragments; D015717:Peptide T; C057977:MSH, gamma, (15-26); D011333:Pro-Opiomelanocortin; C029446:MSH receptor; D009074:Melanocyte-Stimulating Hormones