Transport of L-cystine in human umbilical vein endothelial cells in culture.
The uptake of L-cystine into cultured human umbilical vein endothelial cells has been shown to occur by a Na+-independent system which is inhibited by L-glutamate and L-homocysteine, but not by other amino acids. It is likely that the system transporting L-cystine is shared by L-glutamate. Thiol groups associated with membrane bound components appear to be essential for L-cystine uptake but it is not yet evident whether these constitute an integral part of the transporter per se.
Ewadh
M J
MJ
Department of Biochemistry, University College, Cardiff, UK.
Tudball
N
N
Rose
F A
FA
D001692:Biological Transport; D002478:Cells, Cultured; D003553:Cystine / Q000378:metabolism*; D004727:Endothelium / Q000378:metabolism*; D006801:Humans; D014471:Umbilical Veins / Q000378:metabolism
D003553:Cystine