title: Ornithine decarboxylase in the inner ear of the guinea pig.
abstract: L-Ornithine decarboxylase, the rate limiting enzyme of polyamine synthesis and a possible marker enzyme for tissue proliferation and maturation, has been found in the developing guinea pig cochlea using the unlabelled horseradish-peroxidase-antiperoxidase technique. Ornithine decarboxylase-like immunoreactive material was detected in the neurons of the Ganglion spirale and in their axonal and/or dendritic fibers. The location of the enzyme and the possible functional role of ornithine decarboxylase plays in the development and maturation of the auditory organ and of the hearing process are discussed.
authors.affiliation: Institute of Neurobiology and Brain Research, Academy of Sciences, GDR.
authors.forename: M
authors.initials: M
authors.lastname: Müller
authors.forename: H G
authors.initials: HG
authors.lastname: Bernstein
authors.forename: M
authors.initials: M
authors.lastname: Järvinen
authors.forename: A E
authors.initials: AE
authors.lastname: Pajunen
authors.forename: R
authors.initials: R
authors.lastname: Nowak
authors.forename: A
authors.initials: A
authors.lastname: Dorn
mesh_terms: D000375:Aging; D000818:Animals; D003056:Cochlear Nerve / Q000201:enzymology / Q000254:growth & development; D007758:Ear, Inner / Q000201:enzymology* / Q000254:growth & development; D005260:Female; D006168:Guinea Pigs; D006651:Histocytochemistry; D008297:Male; D009474:Neurons / Q000201:enzymology; D009955:Ornithine Decarboxylase / Q000378:metabolism*
chemical_list: D009955:Ornithine Decarboxylase