Absence of myophosphorylase in ethanol induced cardiomyopathy.
The enzyme myophosphorylase is found to be decreased progressively on the basis of histochemical stain in the myocardium of chronically ethanol intoxicated rats. The enzyme completely disappears by the 12th week of ethanol intoxication. The possibility of deficient myophosphorylase playing one of the important roles in the pathogenesis of cardiomyopathy is stressed.
Baruah
J K
JK
Department of Neurology, Medical College of Wisconsin, Milwaukee 53226.
Kinder
D
D
D000437:Alcoholism / Q000201:enzymology* / Q000473:pathology; D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology; D004195:Disease Models, Animal; D000431:Ethanol / Q000633:toxicity*; D006321:Heart / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology; D006005:Phosphorylases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D000431:Ethanol; D006005:Phosphorylases