Effects of pyrazole on the voluntary consumption of ethanol, water and solid food in UChA and UChB rats.
The effect of pyrazole (35 or 70 mg/kg IP) on the voluntary consumption of ethanol, water and solid food was studied in UChA (genetically low ethanol consumer) and UChB (genetically high ethanol consumer) rats of both sexes, under a free choice of 10% v/v ethanol solution, distilled water and solid food. the data were analyzed according to the method previously proposed for recognizing the specific effect on appetite-satiety of ethanol. The effect of pyrazole in UChB rats correlated with the pattern of specific effects on appetite-satiety for ethanol. The only effect observed in UChA rats was a decrease in the intake of solid food and total water. No significant sex differences were observed.
Contreras
S
S
Department of Pharmacology, Faculty of Medicine, Universidad de Chile, Santiago.
Mardones
J
J
D000428:Alcohol Drinking / Q000187:drug effects*; D000818:Animals; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D005260:Female; D008297:Male; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*
D011720:Pyrazoles; C031280:pyrazole