Intramedullary osteosclerosis. A report of the clinicopathologic features of five cases.
The clinicopathologic features of five patients with intramedullary osteosclerosis are presented. The patients, ranging in age from 8 to 52 years (mean 31 years), all presented with pain referred to the lower extremity. The sclerotic lesions involved the entire lower extremity in 1 patient, mid-tibial shaft in 2, distal tibia in 1, and distal fibula in 1 patient. The histopathologic features of intramedullary osteosclerosis overlap with those of melorheostosis. The differential diagnosis also includes a spectrum of entities, each characterized by osteosclerosis and each of which is compared and contrasted to the cases presented.
Abdul-Karim
F W
FW
Department of Pathology, University Hospitals of Cleveland, OH 44106.
Carter
J R
JR
Makley
J T
JT
Morrison
S C
SC
Helper
S D
SD
Joyce
M J
MJ
Linke
T F
TF
D000293:Adolescent; D000328:Adult; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005360:Fibula / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008557:Melorheostosis / Q000175:diagnosis / Q000473:pathology; D008875:Middle Aged; D010026:Osteosclerosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology