Toxicity and character of the effect of some zinc compounds.
Investigation of the parameters of toxicity of 8 zinc compounds revealed some differences in the degree of their risk for persons working with them. The following TSELs (tentative safe exposure levels of harmful substances) have been determined: 0.5 mg/m3 for zinc nitrate and hydrogen and dihydrogen zinc phosphates, 2 mg/m3 for zinc carbonate and zinc selenide, as well as MAC (maximum allowable concentration) for zinc sulphide equal to 5 mg/m3. No TSEL have been set for zinc caprylate and zinc stearate, but intratracheal administration of 50 mg caprylate caused 100%, of stearate 50% death of experimental animals due to pulmonary edema. Maximum tolerable doses were 10 and 1 mg, respectively. Zinc nitrate shows an expressed irritative effect on the skin and a highly expressed effect on the conjunctiva. Zinc phosphates, zinc caprylate and zinc stearate are resorbed by the skin. In all cases, working persons must be protected from the effect of the compounds under study because even though the toxicity of a compound may be rather low, highly noxious compounds may develop in the course of the technological process, e.g., in mechanical treatment of zinc selenide and zinc sulphide monocrystals, hydrogen selenide and hydrogen sulphide, respectively, can be isolated.
Shabalina
L P
LP
I.M. Sechenov First Moscow Medical Institute, USSR.
Spiridonova
V S
VS
D000279:Administration, Cutaneous; D000280:Administration, Inhalation; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D007441:Intubation, Gastrointestinal; D007928:Lethal Dose 50; D051379:Mice; D011654:Pulmonary Edema / Q000139:chemically induced; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects; D015032:Zinc / Q000008:administration & dosage / Q000633:toxicity*
D015032:Zinc