title: [Local and general experimental anti-anaphylactic effect of 554 L, a synthetic antihistaminic].
abstract: 554 L, a synthetic histamine depressant, was first made in September 1956. In spite of the age of this compound, it seemed to us that it may be of interest to examine it for possible experimental general and localised bronchial antianaphylactic activity. In the first experiments, the results showed an anti-anaphylactic effect in guinea pigs that had been sensitised to cow milk. The second study proved that there was an anti-anaphylactic effect locally on the bronchii by an aerosol of 554 L or Hypostamine on guinea pigs that were sensitive to OVA. These results may produce development of this old compound in delayed release and aerosol presentations.
authors.affiliation: Laboratoire d'Immuno-Allergologie, CHR, Angers.
authors.forename: A
authors.initials: A
authors.lastname: Sabbah
authors.forename: M G
authors.initials: MG
authors.lastname: Heulin
authors.forename: M
authors.initials: M
authors.lastname: Drouet
authors.forename: J C
authors.initials: JC
authors.lastname: Bonneau
authors.forename: J
authors.initials: J
authors.lastname: Le Sellin
mesh_terms: D000818:Animals; D001985:Bronchial Provocation Tests; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000188:drug therapy; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology* / Q000627:therapeutic use; D008892:Milk / Q000276:immunology; D010047:Ovalbumin / Q000276:immunology
chemical_list: D007546:Isoquinolines; D010047:Ovalbumin; C003722:tritoqualine
vernacular_title: Effet antianaphylactique expérimental, général et local du 554 L, hypohistaminémiant de synthèse.