IgA glomerulonephritis and pregnancy.
One hundred and sixteen pregnancies in 70 women with a biopsy-proven diagnosis of IgA glomerulonephritis have been analysed. Thirty percent (35) of the fetuses died, 22% (26) were premature and 44% (52) were full term. Maternal renal function declined during pregnancy in 26% (30) and in 2% (2) this was irreversible post-partum. Hypertension developed in 52% (61) of the pregnancies and in 13% (15) this was irreversible. Increased proteinuria was recorded in 62% (74) of the pregnancies. Fetal loss in pregnancies taking place after biopsy diagnosis was lower (16%) than those in which biopsy was performed either during or following the pregnancy (36%).
Packham
D K
DK
Department of Nephrology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
North
R A
RA
Fairley
K F
KF
Whitworth
J A
JA
Kincaid-Smith
P
P
D000026:Abortion, Habitual / Q000209:etiology; D000032:Abortion, Therapeutic; D058186:Acute Kidney Injury / Q000209:etiology; D001706:Biopsy; D001724:Birth Weight; D005260:Female; D005313:Fetal Death; D005922:Glomerulonephritis, IGA / Q000150:complications*; D006801:Humans; D006977:Hypertension, Renal / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D011507:Proteinuria / Q000209:etiology*