title: EBM/11 reactivity in malignant histiocytosis.
abstract: A patient presented initially with a testicular mass, which on biopsy had morphological features consistent with malignant histiocytosis. The tumour cells labelled strongly with EBM/11, a murine monoclonal antibody with high specificity for cells of the human mononuclear phagocyte system. Subsequent clinical and laboratory studies confirmed the diagnosis. As poorly differentiated tumour cells reacted with EBM/11, this antibody may be useful in positively identifying malignant tumours with histiocytic differentiation from malignancies of other types where morphological detail alone is inconclusive in tumour classification.
authors.affiliation: University of Oxford, Nuffield Department of Pathology, John Radcliffe Hospital.
authors.forename: P M
authors.initials: PM
authors.lastname: Kelly
authors.forename: M
authors.initials: M
authors.lastname: McGovern
authors.forename: K C
authors.initials: KC
authors.lastname: Gatter
authors.forename: J M
authors.initials: JM
authors.lastname: Theaker
authors.forename: J O
authors.initials: JO
authors.lastname: McGee
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity; D001853:Bone Marrow / Q000473:pathology; D054747:Histiocytic Sarcoma / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008297:Male; D009000:Monocytes / Q000276:immunology*; D013736:Testicular Neoplasms / Q000276:immunology / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal