A statistical assessment of clinical equivalence.
An observed confidence distribution is proposed as a measure of strength of evidence for practically equivalent efficacies of two treatments. The concept is independent of prior opinions about relevant sizes of a difference in efficacy. It also avoids retrospective power calculations for trials with missed recruitment goals and allows combination of the confidence from independent experiments.
Mau
J
J
Institute of Medical Biometry, University of Tubingen, F.R.G.
D001499:Bayes Theorem; D002986:Clinical Trials as Topic; D006801:Humans; D008433:Mathematics; D015233:Models, Statistical