Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects.
Thirteen subjects between the ages of 50 years and 70 years were administered a daily 25,000 IU dose of retinol for 9 months. Two subjects experienced mild skin dryness, headaches, and/or alopecia. There were no significant changes in serum chemistries. High performance liquid chromatography assays for plasma retinol revealed no evidence of drug accumulation; however, there was a significant increase in the plasma concentration-versus-time curve for retinyl palmitate concentrations between the first and subsequent sampling days (P = 0.009). The mean skin retinol and retinyl palmitate concentrations in 7 retinol-treated subjects (131.7 and 15.9 ng/g, respectively) were not significantly different from those observed in 13 age-matched controls (118.9 and 25.5 ng/gm, respectively).
Alberts
D S
DS
Department of Medicine, University of Arizona College of Medicine, Tucson.
McDonald
L
L
Edwards
L
L
Peng
Y M
YM
Xu
M J
MJ
Slymen
D J
DJ
Earnest
D L
DL
Ritenbaugh
C
C
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000368:Aged; D000970:Antineoplastic Agents / Q000633:toxicity; D004224:Diterpenes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000084562:Retinyl Esters; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D014018:Tissue Distribution; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity
D000970:Antineoplastic Agents; D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate