[Liver metabolism of indocyanine green and aminopyrine in liver cirrhosis: relations with functioning liver cell mass].
Hepatic clearance of indocyanine green, a drug with a high hepatic extraction rate, and breath tests with aminopyrine, a drug with a low hepatic extraction ratio, were calculated in 26 patients with liver cirrhosis. In addition galactose elimination capacity was calculated as an index of functional liver cell mass. All these parameters resulted significantly correlated with each other. These results confirm the view that during liver cirrhosis, metabolism of drugs with high and low hepatic extraction rates can be described according to the intact hepatocyte theory.
Bolognesi
M
M
Università di Padova, Istituto di Medicina Clinica.
Merkel
C
C
Angeli
P
P
Caregaro
L
L
Gatta
A
A
D000328:Adult; D000632:Aminopyrine / Q000378:metabolism*; D001944:Breath Tests; D005260:Female; D005690:Galactose / Q000378:metabolism; D006801:Humans; D007208:Indocyanine Green / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
D000632:Aminopyrine; D007208:Indocyanine Green; D005690:Galactose
Il metabolismo epatico del verde indocianina e dell'aminopirina nella cirrosi epatica: rapporti con la massa epatica funzionante.