Neurological features in AIDS patients: studies on cerebrospinal fluid.
The relationship between cerebrospinal fluid (CSF) markers of HIV infection and the spectrum of neurological manifestations were studied in 15 AIDS patients (13 with and 2 without confirmed neurological disorders). We demonstrated the presence of intrathecally synthesized anti-HIV antibodies. Antibodies to HIV envelope proteins were present in all patients but those to HIV core proteins in 9/13 cases only. HIV antigen and HIV p24 antigen were present in 6/14 and 4/12 cases respectively. HIV was not isolated from 6 samples of CSF. We have demonstrated that CSF markers of HIV infection were present in all AIDS patients, with or without neurological manifestations. Moreover HIV p24 antigen seems to be a very reliable marker of HIV infection.
Ortona
L
L
Istituto di Clinica delle Malattie Infettive, Università Cattolica del Sacro Cuore, Roma.
Tamburrini
E
E
Antinori
A
A
Ventura
G
G
D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid* / Q000150:complications / Q000276:immunology; D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000276:immunology; D005260:Female; D015483:HIV Antibodies / Q000134:cerebrospinal fluid*; D015488:HIV Antigens / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged
D015483:HIV Antibodies; D015488:HIV Antigens