Hemolytic uremic syndrome: urate nephropathy superimposed on an acute glomerulopathy? An hypothesis.
The oligo-anuria of the hemolytic uremic syndrome is attributed to the presence of a renal lesion which is predominantly glomerulopathic but which may have a vasculopathic component of varying severity. Fourteen children, four of whom had anuric, four oliguric and six non oliguric acute renal failure were treated with intravenous fluids and high dose intravenous furosemide therapy. Polyuria was induced in all, obviating the need for dialysis. We hypothesize that oligo-anuria in this syndrome may be due to the previously recognized hyperuricemia causing a urate nephropathy superimposed on the glomerulopathy thus explaining its possible amenability to fluid and diuretic therapy.
O'Regan
S
S
Department of Pediatrics, University of Montreal, Hôpital Ste-Justine, Quebec, Canada.
Rousseau
E
E
D058186:Acute Kidney Injury / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D001002:Anuria / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D011232:Chemical Precipitation; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005440:Fluid Therapy; D005665:Furosemide / Q000008:administration & dosage / Q000627:therapeutic use; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D008954:Models, Biological; D013997:Time Factors; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid; D005665:Furosemide