title: Condensation of oligoglycines with trimeta- and tetrametaphosphate in aqueous solutions.
abstract: The dehydration condensation of glycine with trimetaphosphate in aqueous solution has been reinvestigated. Although it has been reported that the condensation of glycine under the alkaline conditions was brought about through the formation of cyclic acylphosphoramidate and hence the condensation of polyglycines could not occur, we found that the condensation of oligoglycines with trimeta- and tetrametaphosphate in aqueous solution are possible through the formation of their acylphosphates under the neutral or weak acidic conditions. Aqueous solutions of 1.0 M glycylglycine and 1.0 M trimetaphosphate in the various pH from 4.0 to 9.0 were incubated at 38 degrees C. The solutions were analyzed by HPLC with ninhydrin reaction system. Tetraglycine and hexaglycine were detected and their maximum yields were given in the reaction carried out around pH 7. They are approximately 15% and 4% after 30 days, respectively. Analogous experiments were performed with tetrametaphosphate. The results showed a similar pH dependence for the condensation, but the yields were about one-tenth of those of corresponding experiments with trimetaphosphate. Relative rates of dimerization of glycine, diglycine and triglycine in the equimolar concentration were also investigated at pH 6.0 at 38 degrees C. The rates for diglycine and triglycine were approximately twice and four times as large as that for glycine. Relevance of the experiments to chemical evolution is discussed.
authors.affiliation: Department of Physics, Faculty of Science, Kanazawa University, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Yamanaka
authors.forename: K
authors.initials: K
authors.lastname: Inomata
authors.forename: Y
authors.initials: Y
authors.lastname: Yamagata
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D005998:Glycine / Q000031:analogs & derivatives*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D011122:Polyphosphates
chemical_list: D011122:Polyphosphates; C009293:trimetaphosphoric acid; C022074:sodium tetrametaphosphate; D005998:Glycine