title: Long-term follow-up of right ventricular function after Mustard operation for transposition of the great arteries.
abstract: As development of right ventricular (RV) failure is a potential risk after Mustard operation for transposition of the great arteries, 17 patients were reexamined 5-13 years postoperatively. Comparisons were made with healthy controls. There were no clinical signs of heart failure. Echocardiographically determined RV end-diastolic diameter was increased to 2.5 +/- 0.8 cm (controls: 1.5 +/- 0.4 cm, p less than 0.001). Comparison of RV systolic time intervals (STI) in patients with normal left ventricular (LV) STI revealed decreased RV function, with RPEPI 165 +/- 19 msec (controls 126 +/- 12, p less than 0.001) and RPEP/RVET 0.484 +/- 0.096 (controls 0.284 +/- 0.045, p less than 0.001). Nuclear angiography demonstrated decreased RV ejection fraction (EF), viz. 42.8 +/- 6.6% (normal RV 53 +/- 6%, LV 68 +/- 9%, p less than 0.001). Only two patients showed normal (5%) rise in RV-EF during exercise. There was no evidence of deterioration with passage of time. The results do not justify use of anatomic repair at our center, since the perioperative mortality might then be higher than in the Mustard or Senning procedures.
authors.affiliation: Cardiovascular Laboratory of Medical Department B, Rigshospitalet, Copenhagen, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Buch
authors.forename: A
authors.initials: A
authors.lastname: Wennevold
authors.forename: J R
authors.initials: JR
authors.lastname: Jacobsen
authors.forename: K
authors.initials: K
authors.lastname: Hvid-Jacobsen
authors.forename: P
authors.initials: P
authors.lastname: Lauridsen
mesh_terms: D000792:Angiography; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000503:physiopathology*; D006333:Heart Failure / Q000503:physiopathology*; D006352:Heart Ventricles; D006801:Humans; D007223:Infant; D008297:Male; D008722:Methods; D011183:Postoperative Complications / Q000503:physiopathology*; D014188:Transposition of Great Vessels / Q000601:surgery*