[Plasminogen activators in malignant tissues and lungs of mice during metastatic spreading and administration of various pharmacological agents].
The method of fibrin plates and electrophoresis in PAAG was used to study the activity and forms of plasminogen activators (PA) in extracts of normal tissues (muscle, lungs) as well as of the malignant tumours and the lungs of mice during metastatic spreading and under certain drugs (trielin and cyclophosphane). It was stated that determination of the specific activity level of plasminogen activator in a target organ (lungs) may be used as one of the indices during evaluation of the antimetastatic effect.
Chubinskaia
S G
SG
Makogonenko
E M
EM
Veksler
I G
IG
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005260:Female; D008168:Lung / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology; D010960:Plasminogen Activators / Q000378:metabolism*
D000970:Antineoplastic Agents; D010960:Plasminogen Activators
Aktivatory plazminogena v tkaniakh zlokachestvennykh novoobrazovaniĭ i legkikh mysheĭ pri metastazirovanii i nekotorykh farmakologicheskikh vozdeĭstviiakh.