Biosynthesis of staurosporine, 1. 1H- and 13C-NMR assignments.
Complete and unambiguous assignments of the 1H- and 13C-nmr spectra of the potent antitumor antibiotic staurosporine have been accomplished using a combination of one- and two-dimensional nmr techniques, including one-bond and long-range heteronuclear multiple-quantum coherence spectroscopy (HMQC). Staurosporine was found to be highly cytotoxic in the KB and P-388 assays but was inactive in the microtubulin assembly assay.
Meksuriyen
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Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612.
Cordell
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GA
D000470:Alkaloids / Q000096:biosynthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008870:Microtubules / Q000187:drug effects; D019311:Staurosporine; D013302:Streptomyces / Q000378:metabolism
D000470:Alkaloids; D019311:Staurosporine