title: Effect of neonatal monosodium-L-glutamate treatment on the response of isolated uterine preparation to various uterine contraction stimulators.
abstract: 1. The uterine activity of rats treated neonatally with MSG was examined in vitro by measuring the contractile response of the tissue to hormone/chemical stimulation. 2. The uterine responses to ACh and ANG II remained unchanged following neonatal MSG treatment while those to PGF2 alpha were sensitized. 3. The responses to OT and 5-HT were characterized by a reduction of the maximal contractile force and the rate of change in tension increased and decreased compared with the control with OT and 5-HT respectively. 4. Data suggested that these changes on uterine contractility could be ascribed to various possible mechanisms of action of MSG.
authors.affiliation: Department of Physiology, Chinese University of Hong Kong, Shatin, N.T.
authors.forename: C C
authors.initials: CC
authors.lastname: Wong
authors.forename: J Y
authors.initials: JY
authors.lastname: Chu
authors.forename: K W
authors.initials: KW
authors.lastname: Chiu
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000420:Albuterol / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D015237:Dinoprost / Q000494:pharmacology; D005260:Female; D005971:Glutamates / Q000633:toxicity*; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012970:Sodium Glutamate / Q000633:toxicity*; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: D005971:Glutamates; D000804:Angiotensin II; D015237:Dinoprost; D000109:Acetylcholine; D000420:Albuterol; D012970:Sodium Glutamate