Nitrendipine blocks high potassium contractures but not twitches in rat skeletal muscle.
The effects of the organic calcium channel blocker nitrendipine was tested on electrically evoked twitches and on potassium depolarization-induced contractures of rat lumbricalis muscles. Nitrendipine (10(-7) to 5 X 10(-5) M) blocked only the potassium contractures. It was concluded that blocking calcium uptake through the slow voltage-sensitive calcium channels during potassium depolarization blocks the mechanical response of the muscle. Thus extracellular calcium ions are required for the excitation-contraction (E-C) coupling during depolarization contractures. On the other hand, electrically evoked twitches were not affected by nitrendipine; therefore, extracellular calcium ions entering via the slow voltage-sensitive channels are not required for E-C coupling during the twitch.
Frank
G B
GB
Department of Pharmacology, University of Alberta, Edmonton, Canada.
Konya
L
L
Sudha
T S
TS
D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009568:Nitrendipine / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009568:Nitrendipine; D011188:Potassium