title: Prevalence of symptoms generally attributed to hypertension or its treatment: study on blood pressure in elderly outpatients (SPAA).
abstract: A number of symptoms that appear to be associated with high blood pressure (headache, dizziness, epistaxis, tinnitus, weakness, drowsiness), and are usually regarded as secondary to hypertension or to antihypertensive drug therapy, were studied in 3858 elderly patients, 67.8% of whom were hypertensive. Of the hypertensive patients, 71.2% were under treatment. Headaches and dizziness were significantly more prevalent in the hypertensive than in the normotensive subjects (32.5 versus 27.4% and 41.5 versus 35.3%, respectively; P less than 0.05) and in treated compared with untreated hypertensives (33.3 versus 29.4% and 43.3 versus 37.1%; P less than 0.05). These differences disappeared after statistical correction for 'awareness of hypertension'. In multiple logistic analysis, female sex, age and awareness of hypertension were significantly associated with a higher prevalence of symptoms, whereas hypertension and antihypertensive treatment were not. We conclude that the presence of these symptoms does not constitute a reliable criterion for starting antihypertensive treatment or judging its efficacy.
authors.affiliation: Istituto di Richerche Farmacologiche Mario Negri, Università di Milano, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Di Tullio
authors.forename: C
authors.initials: C
authors.lastname: Alli
authors.forename: F
authors.initials: F
authors.lastname: Avanzini
authors.forename: G
authors.initials: G
authors.lastname: Bettelli
authors.forename: F
authors.initials: F
authors.lastname: Colombo
authors.forename: M A
authors.initials: MA
authors.lastname: Devoto
authors.forename: R
authors.initials: R
authors.lastname: Marchioli
authors.forename: G
authors.initials: G
authors.lastname: Mariotti
authors.forename: M
authors.initials: M
authors.lastname: Radice
authors.forename: E
authors.initials: E
authors.lastname: Taioli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000009:adverse effects*; D001794:Blood Pressure; D004244:Dizziness / Q000139:chemically induced / Q000209:etiology; D004844:Epistaxis / Q000209:etiology; D005260:Female; D006261:Headache / Q000139:chemically induced / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications*; D009123:Muscle Hypotonia / Q000139:chemically induced / Q000209:etiology; D012494:Sampling Studies; D012894:Sleep Stages; D014012:Tinnitus / Q000209:etiology
chemical_list: D000959:Antihypertensive Agents