An immunofluorescence study of lichen planus among Asians in Singapore.
Forty-five Asian patients (Indians 35, Chinese 8, Malay 2) with histologically proven lichen planus were studied by immunofluorescence. The most characteristic feature, seen in 93% of the cases, was shaggy deposition of fibrinogen along the basement membrane. Immunoglobulin deposition along the basement membrane was notably, absent. Colloid bodies were observed in 87% of the cases. Fibrinogen was the most common immunoreactant, and its presence in colloid bodies was always associated with fibrinogen deposition along the basement membrane zone. Colloid bodies also contained a variety of other immunoreactants. However, staining for IgM was noted to be the most intense. The combination of shaggy deposition of fibrinogen along the basement membrane, in the absence of immunoglobulins, and the presence of colloid bodies around the basement membrane zone, is highly characteristic of lichen planus. The pattern of immunofluorescence among Asians with lichen planus, conforms to that observed in other races. There did not appear to be any difference in the immunofluorescence staining with pattern in the three racial groups studied.
Lim
K B
KB
Middle Road Hospital, Singapore.
D000293:Adolescent; D000328:Adult; D001485:Basement Membrane / Q000032:analysis; D002681:China / Q000208:ethnology; D003102:Colloids / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007194:India / Q000208:ethnology; D008010:Lichen Planus / Q000208:ethnology / Q000378:metabolism / Q000473:pathology*; D008296:Malaysia / Q000208:ethnology; D008297:Male; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D012846:Singapore
D003102:Colloids; D007136:Immunoglobulins; D005340:Fibrinogen