Suppression of carbon monoxide excretion by zinc mesoporphyrin in adult Wistar rats: evidence for potent in vivo inhibition of bilirubin production.
We studied the effect of zinc mesoporphyrin on the CO excretion rate (VeCO) and liver heme oxygenase activity of adult rats. A subcutaneous dose of 4 mumol/kg significantly lowered the VeCO between 4 and 12 hours after injection. The liver heme oxygenase activity of treated animals was significantly lower 12 hours after treatment. These findings demonstrate that zinc mesoporphyrin is a potent inhibitor of in vivo total bilirubin production, as measured by the VeCO.
Hamori
C J
CJ
Department of Pediatrics, Stanford University School of Medicine, CA 94305.
Vreman
H J
HJ
Stevenson
D K
DK
D000818:Animals; D001663:Bilirubin / Q000096:biosynthesis*; D002248:Carbon Monoxide / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000032:analysis / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008665:Metalloporphyrins / Q000494:pharmacology*; D011524:Protoporphyrins / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D008665:Metalloporphyrins; D011524:Protoporphyrins; C055421:tin mesoporphyrin; C017803:zinc protoporphyrin; D002248:Carbon Monoxide; C058069:zinc mesoporphyrin; C032628:tin protoporphyrin IX; D006419:Heme Oxygenase (Decyclizing); D001663:Bilirubin