Oxygen binding properties, capillary densities and heart weights in high altitude camelids.
The oxygen binding properties of the blood of the camelid species vicuna, llama, alpaca and dromedary camel were measured and evaluated with respect to interspecific differences. The highest blood oxygen affinity, not only among camelids but of all mammals investigated so far, was found in the vicuna (P50 = 17.6 Torr compared to 20.3-21.6 Torr in the other species). Low hematocrits (23-34%) and small red blood cells (21-30 microns 3) are common features of all camelids, but the lowest values are found in the Lama species. Capillary densities were determined in heart and soleus muscle of vicuna and llama. Again, the vicuna shows exceptional values (3720 cap/mm2 on average in the heart) for a mammal of this body size. Finally, heart weight as percent of body weight is higher in the vicuna (0.7-0.9%) than in the other camelids studied (0.5-0.7%). The possibility that these parameters, measured in New World tylopodes at sea level, are not likely to change considerably with transfer to high altitude, is discussed. In the vicuna, a unique combination of the following features seems to be responsible for an outstanding physical capability at high altitude: saturation of blood with oxygen in the lung is favored by a high blood oxygen affinity, oxygen supply being facilitated by low diffusion distances in the muscle tissue. Loading, as well as unloading, of oxygen is improved by a relatively high oxygen transfer conductance of the red blood cells, which is due to their small size and which compensates the negative effect of a low hematocrit on the oxygen conductance of blood.(ABSTRACT TRUNCATED AT 250 WORDS)
Jürgens
K D
KD
Zentrum Physiologie, Medizinische Hochschule Hannover, Federal Republic of Germany.
Pietschmann
M
M
Yamaguchi
K
K
Kleinschmidt
T
T
D019794:2,3-Diphosphoglycerate; D000531:Altitude; D000818:Animals; D001188:Artiodactyla / Q000378:metabolism*; D002161:Camelids, New World / Q000033:anatomy & histology / Q000097:blood / Q000378:metabolism*; D002162:Camelus / Q000033:anatomy & histology / Q000097:blood / Q000378:metabolism*; D002196:Capillaries / Q000033:anatomy & histology; D003326:Coronary Circulation; D004163:Diphosphoglyceric Acids / Q000494:pharmacology; D004912:Erythrocytes / Q000166:cytology; D006321:Heart / Q000033:anatomy & histology*; D006454:Hemoglobins / Q000378:metabolism; D009132:Muscles / Q000098:blood supply*; D009929:Organ Size; D010100:Oxygen / Q000097:blood / Q000378:metabolism*
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D019794:2,3-Diphosphoglycerate; D010100:Oxygen