Effects of nontoxic lipid A and endotoxin on resistance of mice to Toxoplasma gondii.
Mice were administered nontoxic monophosphoryl lipid A (MPL) or refined standard bacterial endotoxin (RSE) prior to, simultaneously with, or after infection with Toxoplasma gondii. MPL and RSE given before or with the toxoplasma infection induced significant resistance. Administration of toxic RSE, but not nontoxic MPL, after the establishment of toxoplasma infection significantly shortened the survival time of mice.
Masihi
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Robert Koch Institute, Federal Health Office, Berlin, F.R.G.
Ribi
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Lange
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Werner
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D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D004731:Endotoxins / Q000627:therapeutic use*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008050:Lipid A / Q000627:therapeutic use*; D051379:Mice; D012475:Salmonella; D014124:Toxoplasmosis, Animal / Q000276:immunology
D004731:Endotoxins; D008050:Lipid A