Effect of venous stasis and physical exercise on plasma extracellular-superoxide dismutase.
The secretory protein extracellular-superoxide dismutase is the major superoxide dismutase (SOD) isoenzyme in the extracellular space. There is evidence to suggest that most extracellular-superoxide dismutase in the vascular system is bound to endothelial cell surfaces. Venous stasis and physical exercise is known to induce release of several endothelium-associated factors into the plasma. However, venous stasis and physical exercise were not found to induce any release of extracellular-superoxide dismutase into plasma. The plasma activity of the intracellular isoenzyme CuZn SOD was doubled by venous stasis.
Nilsson
S
S
Department of Clinical Chemistry, Umeå University Hospital, Sweden.
Marklund
S L
SL
D000328:Adult; D005110:Extracellular Space / Q000201:enzymology*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D013482:Superoxide Dismutase / Q000097:blood*; D014680:Veins / Q000502:physiology*
D007527:Isoenzymes; D013482:Superoxide Dismutase