title: Antidepressants and human memory: an investigation of four drugs with different sedative and anticholinergic profiles.
abstract: The effects on memory and psychomotor functions of four antidepressants which differ in sedative and anticholinergic properties were assessed. Amitriptyline (37.5, 70 mg), trazodone (100, 200 mg) viloxazine (100, 200 mg), protriptyline (10, 20 mg) or placebo were administered in a double blind, independent groups design in which 90 subjects participated. Subjects completed a battery of tests before and 2 and 4 h after drug administration. The different antidepressants produced different patterns of effects across tasks. The relatively non-sedating compounds viloxazine and protriptyline produced very similar profiles and did not impair psychomotor or memory functions. In contrast, the two more sedative antidepressants produced global impairments on test of attention, manual motor speed, recording skills and primary memory. Although both amitriptyline and trazodone impaired performance on episodic memory tasks, the effect of amitriptyline was significantly greater and this may reflect specific anticholinergic action over and above global sedative effects.
authors.affiliation: Department of Psychiatry, Institute of Psychiatry, London, UK.
authors.forename: H V
authors.initials: HV
authors.lastname: Curran
authors.forename: M
authors.initials: M
authors.lastname: Sakulsriprong
authors.forename: M
authors.initials: M
authors.lastname: Lader
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005425:Flicker Fusion / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D012472:Salivation / Q000187:drug effects; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D006993:Hypnotics and Sedatives; D010276:Parasympatholytics