Radio-induced sarcomas in survivors of Ewing's sarcoma.
Of 255 cases of Ewing's sarcoma recorded at the Bone Tumor Center of the Rizzoli Orthopaedic Institute, 78 patients (irradiated and with a follow-up of longer than 3 years) were considered "at risk" for the development of a second radio-induced sarcoma (RIS). Three of the 78 patients developed an RIS in the irradiated field. Theoretical and statistical analyses were carried out considering different modalities of local treatment. Statistically, the only significant factor was related to the irradiation dose. Surgical resection seems to prevent RIS.
Boriani
S
S
1st Orthopaeidic Clinic, University of Bologna, Italia.
Picci
P
P
Sudanese
A
A
Toni
A
A
Mancini
A
A
Frezza
G
G
Barbieri
E
E
Baldini
N
N
Monesi
M
M
Ciaroni
D
D
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D006801:Humans; D009378:Neoplasms, Multiple Primary; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D012509:Sarcoma / Q000209:etiology*; D012512:Sarcoma, Ewing / Q000532:radiotherapy* / Q000601:surgery