Biphasic response of coronary arterial diameter to intracoronary ergonovine.
This report presents a case of paradoxical coronary arterial dilation induced by intracoronary ergonovine. When compared with the control angiogram, the right coronary artery obviously dilated with selective, intracoronary administration of cumulative doses of 5 micrograms and 15 micrograms ergonovine without concomitant hemodynamic changes. Additional intracoronary infusion of 35 micrograms ergonovine into the right coronary artery inversely increased vascular tone of the vessel associated with a focal hyperconstriction. Such a biphasic response of arterial diameter to intracoronary ergonovine was also observed in the left coronary artery, but the degree of dilation was much smaller.
Mohri
M
M
Research Institute of Angiocardiology and Cardiovascular Clinic, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Okamatsu
S
S
Nakamura
M
M
D000788:Angina Pectoris, Variant / Q000175:diagnosis*; D003326:Coronary Circulation / Q000187:drug effects*; D003329:Coronary Vasospasm / Q000175:diagnosis; D004305:Dose-Response Relationship, Drug; D004874:Ergonovine; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis; D014661:Vasoconstriction / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*
D004874:Ergonovine