The effects of pentoxifylline on cochlear blood flow in normotensive and spontaneously hypertensive rats.
Normotensive and spontaneously hypertensive rats (SHRs) were given arterial infusions of saline and pentoxifylline in doses of 1.5, 2.0, and 3.0 mg/kg/min. Blood pressure decreased in a dose related fashion with increasing doses of pentoxifylline. Cochlear blood flow, measured via laser Doppler flowmeter, increased with infusion of pentoxifylline in members of both rat strains, but to a greater extent in SHRs than in normotensive animals. The mechanism of action appears to be decreased red blood cell rigidity which allows increased penetration of red blood cells into microvessels of the cochlea.
Quirk
W S
WS
Department of Psychology, Washington State University, Pullman 99164.
Dengerink
H A
HA
Bademian
M J
MJ
Hall
K W
KW
Wright
J W
JW
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003051:Cochlea / Q000098:blood supply*; D004305:Dose-Response Relationship, Drug; D006973:Hypertension / Q000503:physiopathology*; D007262:Infusions, Intravenous; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012039:Regional Blood Flow / Q000187:drug effects; D013805:Theobromine / Q000031:analogs & derivatives*; D014655:Vascular Resistance / Q000187:drug effects
D013805:Theobromine; D010431:Pentoxifylline