Binding pattern of alpha-bungarotoxin on horizontal cells of a marine teleost retina.
A conjugate of alpha-bungarotoxin and a fluorescent marker (fluorescein isothiocyanate) has been used to localize "nicotinic" acetylcholine receptors on neurons in the outer plexiform layer of marine teleost retina. Toxin binding was confined to bipolar cell dendrites and to intermediate horizontal cells. The arrangement of labeled horizontal cells appears irregular in the whole retina, with a peak density in the ventral and dorsal quandrants. Alpha-bungarotoxin receptors on horizontal cells differ from those on bipolar cells and from those on dendrites in the inner plexiform layer in their sensitivity to agonists and antagonists such as d-tubocurarine and nicotine. They constitute a different type of "nicotinic" receptor that probably has a different function.
Deplano
S
S
Institute of Comparative Anatomy, University of Genoa, Italy.
D000818:Animals; D005399:Fishes / Q000378:metabolism*; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000378:metabolism*; D011978:Receptors, Nicotinic; D012160:Retina / Q000166:cytology / Q000378:metabolism*; D064569:alpha7 Nicotinic Acetylcholine Receptor
D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor