title: Effects of short term experimental diabetes on brain serotonin metabolism.
abstract: Serotonin metabolism was studied in several brain regions of control and Streptozotocin-treated male Wistar rats. After induction of diabetes, the animals were killed at 24 hours. Concentrations of brain tryptophan show a generalized increase in all brain regions, being only significant in medulla-pons. Serotonin levels do not change, while 5-HIAA concentrations, as well as the ratio 5-HIAA/5-HT, show significant increases in medulla-pons and mid-brain.
authors.affiliation: Departamento de Fisiología, Facultad de Biología, Santiago de Compostela, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Atienza
authors.forename: M
authors.initials: M
authors.lastname: Aldegunde
authors.forename: R
authors.initials: R
authors.lastname: Durán
authors.forename: J A
authors.initials: JA
authors.lastname: Veira
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors; D014364:Tryptophan / Q000378:metabolism
chemical_list: D012701:Serotonin; D014364:Tryptophan