title: An international study on the occurrence of multiresistant bacteria and aminoglycoside consumption patterns.
abstract: The correlation between aminoglycoside consumption patterns and the occurrence of aminoglycoside-resistant bacteria from 12 different countries was analyzed. Regional and national data were collected retrospectively and compared. There was evidence of a wide variation of the national aminoglycoside consumption patterns in the different countries. There was a striking correlation of gentamicin resistance and the total national aminoglycoside and national gentamicin consumption. In addition, there was a clear correlation between bacterial resistance inside and outside the hospital to the total amount of aminoglycoside, particularly gentamicin, consumption in hospitals. In a number of countries, an increase in the frequency of gentamicin-resistant bacterial strains could be noticed. For amikacin, only a correlation of staphylococcal resistance in hospitalized patients to the total amount of national aminoglycoside and amikacin consumption could be found.
authors.affiliation: WHO Regional Office for Europe, Quality of Care and Technologies, Copenhagen.
authors.forename: K S
authors.initials: KS
authors.lastname: Johansen
authors.forename: M
authors.initials: M
authors.lastname: Storgaard
authors.forename: N
authors.initials: N
authors.lastname: Carstensen
authors.forename: U
authors.initials: U
authors.lastname: Frank
authors.forename: F
authors.initials: F
authors.lastname: Daschner
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003625:Data Collection; D004352:Drug Resistance, Microbial; D006801:Humans; D012189:Retrospective Studies
chemical_list: D000617:Aminoglycosides