Comparison of 0.5% cyclopentolate plus 0.5% tropicamide and 1% cyclopentolate alone for mydriasis of dark irides.
We studied the mydriatic and cycloplegic effect of a single dose of a combination of 0.5% cyclopentolate hydrochloride and 0.5% tropicamide in 20 healthy subjects with dark brown irides. The mean change in dilatation with the combination drop was 3.5 mm, compared with 0.6 mm with 1% cyclopentolate alone (p less than 0.001). In 92% of 26 eyes studied the difference in refraction between the combination drop and 1% atropine was +1.00 dioptre or less. The combination drop safely provided satisfactory mydriasis and cycloplegia in 20 minutes, allowing for rapid and accurate examination of these patients.
Nishizawa
A R
AR
Ivey Institute of Ophthalmology, Victoria Hospital, London, Ont.
Orton
R B
RB
Cadera
W
W
D001285:Atropine / Q000008:administration & dosage; D003519:Cyclopentolate / Q000008:administration & dosage*; D004338:Drug Combinations; D005127:Eye Color; D006801:Humans; D010648:Phenylacetates / Q000008:administration & dosage*; D011680:Pupil / Q000187:drug effects*; D011725:Pyridines / Q000008:administration & dosage*; D014331:Tropicamide / Q000008:administration & dosage*
D004338:Drug Combinations; D010648:Phenylacetates; D011725:Pyridines; D001285:Atropine; D003519:Cyclopentolate; D014331:Tropicamide