title: The development of the muscarinic acetylcholine receptor in normal and hyperphenylalaninemic rat cerebrum.
abstract: The effect of hyperphenylalaninemia on the development of the muscarinic acetylcholine receptor in rat cerebrum has been studied. Rats were subjected to the hyperphenylalaninemic regimen as of 5 days of age. A gradual and steady decrease in the number of binding sites for L-[3H]quinuclidinylbenzilate was observed, with the white matter more affected than the gray matter. A return to normal blood phenylalanine levels after the age of 21 days does not lead to an increase in this number of binding sites.
authors.affiliation: Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912-2100.
authors.forename: K
authors.initials: K
authors.lastname: Matsuo
authors.forename: F A
authors.initials: FA
authors.lastname: Hommes
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D010649:Phenylalanine / Q000097:blood* / Q000378:metabolism; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000378:metabolism*
chemical_list: D011976:Receptors, Muscarinic; D010649:Phenylalanine; D011813:Quinuclidinyl Benzilate