title: [Acute poisoning with a narcotic (Tramadol) in an infant of five weeks].
abstract: Accidental rectal administration of 27 mg/kg of the narcotic analgesic Tramadol to a five-week-old infant resulted in severe cerebral depression, which had to be treated with Naloxone during 48 hours. The severity and the duration of this intoxication are not explained solely by the high dosage of Tramadol. A decreased elimination kinetics and an increased permeability of the blood-cerebrospinal fluid barrier probably also account for the pattern of the present intoxication.
authors.affiliation: Clinique de Pédiatrie, Hôpital cantonal universitaire, Genève, Suisse.
authors.forename: M G
authors.initials: MG
authors.lastname: Bianchetti
authors.forename: A
authors.initials: A
authors.lastname: Beutler
authors.forename: P E
authors.initials: PE
authors.lastname: Ferrier
mesh_terms: D000059:Accidents; D000285:Administration, Rectal; D003511:Cyclohexanols / Q000506:poisoning*; D006801:Humans; D007223:Infant; D008297:Male; D009123:Muscle Hypotonia / Q000139:chemically induced* / Q000188:drug therapy; D009270:Naloxone / Q000627:therapeutic use; D012133:Respiratory Paralysis / Q000139:chemically induced* / Q000188:drug therapy; D014147:Tramadol / Q000008:administration & dosage / Q000506:poisoning*
chemical_list: D003511:Cyclohexanols; D009270:Naloxone; D014147:Tramadol
vernacular_title: Intoxication sévère avec un opiacé (Tramadol) chez un nourrisson de cinq semaines.