Bias from non-participation: a study of low-level lead exposure in children.
Epidemiological studies on neurobehavioural effects in childhood are highly sensitive to selection bias. A study on the significance of low-level lead exposure was performed among school children in the first grade in Aarhus in 1982-83. Deciduous teeth were collected and analysed for the circumpulpal dentin lead concentration. On the basis of the lead levels, a case and a control group were identified. Information on socioeconomical status and past medical history was obtained for all children. A "common sense" stratification of the reason for non-participation, showed bias in particular due to non-responders, while "refusers" caused little, if any bias. A non-participation of 7% significantly distorted the main result of the study in the direction of the null-hypothesis. Current studies of low-level lead exposure vary greatly with regard to non-participation and the extent of selection bias may contribute to understand the apparent diversity of findings of studies in this field.
Lyngbye
T
T
Department of Environmental Medicine, Odense University, Denmark.
Hansen
O N
ON
Grandjean
P
P
D002648:Child; D004781:Environmental Exposure; D004812:Epidemiologic Methods; D005500:Follow-Up Studies; D006801:Humans; D007854:Lead / Q000009:adverse effects* / Q000032:analysis; D008137:Longitudinal Studies; D015233:Models, Statistical; D010349:Patient Compliance; D012959:Socioeconomic Factors; D014094:Tooth, Deciduous / Q000032:analysis
D007854:Lead