Linkage of X-linked nephrogenic diabetes insipidus with DXS52, a polymorphic DNA marker.
In five families with X-linked nephrogenic diabetes insipidus (NDI), linkage studies with the DNA marker DXS52, defined by probe St14, have shown no recombination with a maximum combined lod score of 6.40. These results assign the NDI gene to the subtelomeric region of the X chromosome long arm. This finding should facilitate identification of carriers and should also be helpful in finding the NDI gene itself.
Knoers
N
N
Department of Human Genetics, Catholic University, Nijmegen, The Netherlands.
vd Heyden
H
H
von Oost
B A
BA
Monnens
L
L
Willems
J
J
Ropers
H H
HH
D004247:DNA / Q000235:genetics*; D003919:Diabetes Insipidus / Q000209:etiology / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics*; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D014960:X Chromosome
D005819:Genetic Markers; D004247:DNA