Proto-oncogenes II.
In reviewing recent literature on activated proto-oncogenes including retroviral infection (without oncogene), translocation and inherited childhood cancer, I have come to the conclusion that activated proto-oncogenes are not involved in development of tumors. There is one exception in which a translocated proto-myc leads to transformation. That is the case of the trangenic mouse embryo where faulty development occurs.
Rosen
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Hasbrouck Laboratory, University of Massachusetts, Amherst 01003.
D000818:Animals; D005784:Gene Amplification; D006801:Humans; D008957:Models, Genetic; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics; D011519:Proto-Oncogenes; D012190:Retroviridae / Q000235:genetics; D014178:Translocation, Genetic