title: Acute and subacute effects of thiamine deficiency on the morphometry and cell kinetics of jejunal and ileal epithelial cells.
abstract: The effects of acute and subacute thiamine deficiency on jejunal and ileal epithelial cells were studied in rats, using crypt and villus cell population, crypt cell production per crypt (CCPC), crypt growth fraction (Ip) and crypt cell cycle time (Tc) as parameters. In acute thiamine deficiency there was marked jejunal hypoplasia of the crypt and villus, but in the ileum there was hypoplasia only of the crypt. The jejunal epithelium of the subacute thiamine deficiency (STD) group showed no morphometric changes. In contrast, in the ileal epithelium of STD rats there was decreased crypt depth and villus cell population. Thiamine deficiency had no significant effect on CCPC, Ip and Tc.
authors.affiliation: Department of Pathology, Federal University of Fortaleza, Ceará.
authors.forename: T C
authors.initials: TC
authors.lastname: Cipriano
authors.forename: S
authors.initials: S
authors.lastname: Zucoloto
authors.forename: G
authors.initials: G
authors.lastname: Muccilo
authors.forename: J K
authors.initials: JK
authors.lastname: Kajiwara
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D007082:Ileum / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D007583:Jejunum / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008871:Microvilli / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D013831:Thiamine / Q000494:pharmacology; D013832:Thiamine Deficiency / Q000473:pathology*
chemical_list: D013831:Thiamine