title: Is there a relationship between metabolic control and glucose concentration in breast milk of type 1 (insulin-dependent) diabetic mothers?
abstract: We studied glucose concentration of breast milk of nursing diabetic mothers and its possible relationship to the quality of metabolic control. Eleven Type 1 (insulin-dependent) diabetic mothers and 11 age-matched control subjects were included in the study. Although a near-normoglycemic control of diabetic mothers was accomplished by intensified insulin treatment, the HbA1 value was significantly higher in comparison to non-diabetic mothers (8.1 +/- 0.9% versus 6.2 +/- 0.5%; p less than 0.01). Regardless of this, the glucose concentration of breast milk did not differ between diabetic mothers and that of non-diabetic women (0.68 +/- 0.50 mmol/l versus 0.66 +/- 0.55 mmol/l). No correlation exists between glucose concentration of breast milk and relevant blood glucose concentration as well as glycosylated haemoglobin A1 of the mother. In conclusion, our data support the view that breast-feeding of infants of diabetic mothers is not associated with an increased offer of glucose and thus not being of importance as a possible mechanism to sustain a hyperinsulinemic state in the newborns.
authors.affiliation: Centre of Diabetes and Metabolic Disorders, Berlin/GDR.
authors.forename: K P
authors.initials: KP
authors.lastname: Ratzmann
authors.forename: E
authors.initials: E
authors.lastname: Steindel
authors.forename: R
authors.initials: R
authors.lastname: Hildebrandt
authors.forename: R
authors.initials: R
authors.lastname: Kohlhoff
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D001942:Breast Feeding; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000032:analysis*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008895:Milk, Human / Q000032:analysis*
chemical_list: D001786:Blood Glucose; D005947:Glucose; D006442:Glycated Hemoglobin