Brain monoamine levels in suckling mice following postnatal exposure to secalonic acid D via the dam's milk.
Mice were gavage-fed on day 13 of pregnancy with 0 (groups N, 15, 25) or 25 (group P) mg/kg of secalonic acid D (SAD) and again while nursing their offspring on postgestational days 1-10 with 0 (N,P), 15(15) or 25(25) mg/kg/day. SAD residues were present in the stomach of pups nursed by SAD-treated dams. Postnatal exposure to SAD decreased (P less than 0.05) body weight gains of offspring. Treatment decreased the developmental levels of norepinephrine and dopamine in the prosencephalon (forebrain) and cerebellum-pons of the offspring on postnatal days (PND) 7 and 7-16, respectively. On PND 7-16 serotonin and 5-hydroxyindoleacetic acid levels decreased in the prosencephalon and cerebellum-pons of offspring exposed prenatally (P) or postnatally (15,25) to SAD.
Bolon
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Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia 65211.
St Omer
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VE
D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D015306:Biogenic Monoamines / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002395:Catecholamines / Q000032:analysis; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D007211:Indoles / Q000032:analysis; D007774:Lactation / Q000378:metabolism*; D051379:Mice; D008892:Milk / Q000633:toxicity*; D011247:Pregnancy; D014966:Xanthenes / Q000008:administration & dosage / Q000633:toxicity*; D044004:Xanthones
D015306:Biogenic Monoamines; D002395:Catecholamines; D007211:Indoles; D014966:Xanthenes; D044004:Xanthones; C009218:secalonic acid