Effects of apomorphine on punished and unpunished responding in the rat.
Apomorphine has been reported to increase shock-suppressed drinking, which suggests that it might have antianxiety activity. Because some drugs that increase shock-suppressed drinking are not active in other punishment procedures, the effects of apomorphine on punished and unpunished responding maintained by a multiple fixed-interval, fixed-interval schedule of food presentation were studied in rats. At doses from 3.125 to 100 micrograms/kg, apomorphine failed to increase punished or unpunished responding. In contrast, pentobarbital produced large increases in punished responding maintained by a fixed-interval schedule of food presentation.
McMillan
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DE
Department of Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205.
Evans
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RL
D000161:Acoustic Stimulation; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D004597:Electroshock; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D011678:Punishment; D051381:Rats; D011919:Rats, Inbred Strains
D010424:Pentobarbital; D001058:Apomorphine