Collagen cross-linking: distribution of hydroxypyridinium cross-links among invertebrate phyla and tissues.
1. Using a specific HPLC assay, a wide variety of marine invertebrate connective tissues was screened for the 3-hydroxypyridinium amino acids that are prominent intermolecular cross-linking residues in the collagens of many vertebrate connective tissues. 2. One or both of the two structural forms that exist, hydroxylysyl pyridinoline (HP) and lysyl pyridinoline (LP), was found in organisms from the following phyla: coelenterata, Annelida, Echinodermata, Mollusca and Arthropoda. 3. Neither amino acid was found in tissues from representative species of Porifera and Chordata. 4. Of special note was an unusually high ratio of LP to HP in Limulus polyphemus gill cartilage.
Van Ness
K P
KP
Department of Orthopaedics, University of Washington, Seattle 98195.
Koob
T J
TJ
Eyre
D R
DR
D000818:Animals; D005075:Biological Evolution; D003094:Collagen / Q000378:metabolism*; D003238:Connective Tissue / Q000378:metabolism; D007448:Invertebrates / Q000378:metabolism*; D011725:Pyridines / Q000378:metabolism*; D013045:Species Specificity; D014018:Tissue Distribution
D011725:Pyridines; C023500:3-hydroxypyridine; D003094:Collagen