[The participation of dopamine in the vascular reactions and metabolic processes of the brain].
The dopamine effect on the tension of perfused vessels and the arterial BP depended on its doses in acute experiments on anesthetized cats. Dopaminergic vasodilatory components in perfused vessels responses and the BP were determined with joint blockade of alpha- and beta-receptors. Oxygen and glucose consumption increased in the brain during continuous i.v. infusion of various doses of dopamine (5 mg/kg/min and 100 mg/kg/min). The effect of dopamine on blood circulation and cerebral metabolism mediated through adrenergic (alpha- and beta-) and dopaminergic structures, is discussed.
Pchelintseva
T R
TR
Pogorelyĭ
V E
VE
Gaevyĭ
M D
MD
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002415:Cats; D002536:Cerebral Arteries / Q000187:drug effects*; D002550:Cerebral Veins / Q000187:drug effects*; D004298:Dopamine / Q000494:pharmacology*; D018492:Dopamine Antagonists; D004305:Dose-Response Relationship, Drug; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D018492:Dopamine Antagonists; D004298:Dopamine
Uchastie dofamina v sosudistykh reaktsiiakh i metabolicheskikh protsessakh golovnogo mozga.