title: Uptake of 99Tcm-MDP in lung metastasis from osteosarcoma: clinical and animal studies.
abstract: Bone scintigraphy was performed in 17 patients with previously known lung metastases of osteosarcoma. 99Tcm-MDP uptake was observed in all primary bone lesions but lung metastatic lesions were positive in only six patients (35%). 99Tcm-MDP uptake by lung metastases was significantly correlated with bone and osteoid formation in the metastatic lesions and preoperative serum ALPase values. These clinical observations were confirmed by using nude mice transplanted with human lung metastatic osteosarcoma. 99Tcm-MDP scintigraphy appears to be useful for detecting lung metastases of osteosarcoma only in a selected group of patients.
authors.affiliation: Department of Orthopaedic Surgery, Kyoto University Faculty of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsuji
authors.forename: T
authors.initials: T
authors.lastname: Yamamuro
authors.forename: Y
authors.initials: Y
authors.lastname: Kotoura
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: C
authors.initials: C
authors.lastname: Tanaka
authors.forename: J
authors.initials: J
authors.lastname: Toguchida
authors.forename: K
authors.initials: K
authors.lastname: Endo
authors.forename: H
authors.initials: H
authors.lastname: Sakahara
authors.forename: M
authors.initials: M
authors.lastname: Koizumi
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001859:Bone Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000556:secondary*; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate; D014183:Transplantation, Heterologous
chemical_list: D013669:Technetium Tc 99m Medronate