Hypovolemia, hyperosmolality, and acidosis associated with intraperitoneal infusion of nitrofurazone solution in healthy horses.
Nitrofurazone solution containing 0.2% nitrofurazone and 99.8% polyethylene glycol was given to 4 healthy horses (2 L in 2 L of lactated Ringer solution, intraperitoneally). Horses developed hypovolemia, hyperosmolality, and mixed respiratory and metabolic acidosis. These changes were largely attributable to polyethylene glycol, but a contribution of nitrofurazone cannot be excluded. Intraperitoneal infusion of nitrofurazone solution in horses is contraindicated.
Gossett
K A
KA
Department of Veterinary Pathology, Louisiana State University, Baton Rouge 70803.
McCoy
D J
DJ
Jowett
P L
PL
Kearney
M T
MT
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000818:Animals; D001810:Blood Volume / Q000187:drug effects*; D005260:Female; D006736:Horses / Q000097:blood*; D007263:Infusions, Parenteral; D008297:Male; D009583:Nitrofurazone / Q000008:administration & dosage / Q000494:pharmacology*; D009994:Osmolar Concentration; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D009583:Nitrofurazone