title: [Usefulness of gallium 67 in research into the need for radical cervical lymph node dissection in patients with head and neck carcinomas].
abstract: Fifty-nine patients with head and neck carcinoma were examined with 67Ga scintigraphy. All patients had undergone lymph node dissection of the neck. They were followed for a minimum of 2 years after the examination. The primary tumor, treated prior/contemporaneously to the lymph node dissection, did not evolve in this interval. Metastatic involvement of the lymph node capsule was observed in all 44 cases with metastatic lymph nodes; macroscopic radicality was surgically obtained since involvement of the capsule was only microscopic. Nevertheless, complementary radiotherapy was given. The whole of 17 recurrences in the soft tissues of the neck were found, within 2 years, in the group of 26 patients who had undergone dissection of lymph nodes with metastatic capsular involvement and whose postoperative 67Ga scintigraphy was positive. On the contrary, no recurrences in the soft tissues of the neck were observed in the group of 18 patients who had undergone dissection of lymph nodes with metastatic capsular involvement and whose scintigraphy was negative. This result proves (P less than 0.001) 67Ga capable of evidencing eventual microscopic diffusion. Such a possibility has not yet been realized in vivo with any other investigation technique. Scintigraphy was negative in a control group of 15 patients who had undergone lymph node dissection, and with nonmetastatic lymph nodes. This finding leads us to exclude that the use of 67Ga might result in misinterpreted findings in the exploration of relatively superficial tissues. In fact, the eventual accumulation of radioisotope in nonneoplastic pathologies is quite easily recognizable in the neck. We can therefore conclude that in those 9 cases with positive scintigraphy and in whom no recurrence was found, microscopic diffusion was probably present, but local recurrence of the disease was prevented by complementary radiotherapy.
authors.affiliation: Divisione di Radioterapia, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano.
authors.forename: S
authors.initials: S
authors.lastname: Basso Ricci
authors.forename: A
authors.initials: A
authors.lastname: Rodari
authors.forename: R
authors.initials: R
authors.lastname: Molinari
authors.forename: A
authors.initials: A
authors.lastname: Turrin
authors.forename: F
authors.initials: F
authors.lastname: Crippa
authors.forename: R
authors.initials: R
authors.lastname: Castellani
authors.forename: P
authors.initials: P
authors.lastname: Salvatori
authors.forename: A
authors.initials: A
authors.lastname: Sichirollo
mesh_terms: D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D005710:Gallium Radioisotopes; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008207:Lymphatic Metastasis; D009333:Neck; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy / Q000601:surgery
chemical_list: D005710:Gallium Radioisotopes
vernacular_title: Utilità del gallio 67 nella ricerca della radicalità delle dissezioni linfonodali del collo nei pazienti affetti da carcinoma del capo e del collo.