Developmental expression of transforming growth factors alpha and beta in mouse fetus.
Expression of mRNA for transforming growth factor alpha (TGF-alpha) and TGF-beta 1 during the fetal development of mice was evaluated by in situ hybridization. TGF-alpha mRNA was detected in 9- and 10-day fetuses but was absent in older fetuses. TGF-alpha mRNA-containing cells were found in the placenta, otic vesicle, oral cavity, pharyngeal pouch, first and second branchial arches, and developing kidneys. mRNA for TGF-beta 1 was present in hematopoietic cells of blood islands and capillaries and in the liver as it began to bud off on day 10 and function as a hematopoietic organ.
Wilcox
J N
JN
Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080.
Derynck
R
R
D000818:Animals; D001345:Autoradiography; D005314:Embryonic and Fetal Development; D005260:Female; D005333:Fetus / Q000502:physiology*; D005796:Genes; D051379:Mice; D009693:Nucleic Acid Hybridization; D011247:Pregnancy; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics*; D013462:Sulfur Radioisotopes; D014158:Transcription, Genetic; D015291:Transforming Growth Factors / Q000235:genetics*
D012333:RNA, Messenger; D013462:Sulfur Radioisotopes; D015291:Transforming Growth Factors