title: [Changes in the amino acid sequence of hemagglutinin during sequential adaptation of human influenza virus A to replication in mice].
abstract: The primary structure of hemagglutinin (HA) gene of Influenza virus A/USSR/90/77 (H1N1) variants after 3 and 11 passages has been determined. In the HA1 coding region of mice-adapted virus (11 passages) there are two amino acid substitutions: Thr 89----Ala and Asn 127----Asp. At the first stage of adaptation (3-rd passage) only a single mutation was detected: Asn 127----Asp. The adaptation is accompanied by the loss of specific carbohydrate attachment sites adjacent to the receptor-binding site located at HA1 subunit with a concomitant variation in antigenicity.
authors.forename: A A
authors.initials: AA
authors.lastname: Grinev
authors.forename: E I
authors.initials: EI
authors.lastname: Samokhvalov
authors.forename: N A
authors.initials: NA
authors.lastname: Petrov
authors.forename: S K
authors.initials: SK
authors.lastname: Vasilenko
authors.forename: V P
authors.initials: VP
authors.lastname: Iuferov
mesh_terms: D000220:Adaptation, Biological; D000595:Amino Acid Sequence; D000818:Animals; D006389:Hemagglutinins, Viral / Q000032:analysis / Q000235:genetics*; D006801:Humans; D009980:Influenza A virus / Q000235:genetics* / Q000502:physiology; D051379:Mice; D008969:Molecular Sequence Data; D014779:Virus Replication
chemical_list: D006389:Hemagglutinins, Viral
vernacular_title: Izmeneniia aminokislotnoĭ posledovatel'nosti gemaggliutinina pri posledovatel'nykh étapakh adaptatsii virusa grippa A cheloveka k razmnozheniiu v organizme mysheĭ.