[Status of the antioxidant system and free radical lipid peroxidation in patients with chronic renal failure].
Function of the antioxidant system (AOS) and intensity of lipid peroxidation (LPO) were studied in 42 patients with different stages of chronic renal insufficiency (CRI). The AOS state was studied by means of defining the content of SH-groups in erythrocytes using a method of quantitative cytochemistry, LPO activity was determined according to the level of diene conjugates of polyunsaturated higher fatty acids in the erythrocytic membrane by spectrophotometry. AOS functional incompetence was found in uremic patients. Of diagnostic importance was parallelism revealed between a degree of AOS damage and CRI stages. The results of investigation indicated the presence of marked imbalance between AOS and LPO, causing probably some clinical manifestations in CRI patients. Antioxidant preparations could be recommended for use in combined therapy of CRI patients.
Grinshteĭn
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IuI
Andrianova
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GP
D000293:Adolescent; D000328:Adult; D000975:Antioxidants; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D005609:Free Radicals; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D013438:Sulfhydryl Compounds / Q000097:blood*
D000975:Antioxidants; D005609:Free Radicals; D013438:Sulfhydryl Compounds
Sostoianie antioksidantnoĭ sistemy i svobodnoradikal'noe okislenie lipidov u bol'nykh s khronicheskoi pochechnoĭ nedostatochnost'iu.