Neurogenic inflammation in the skin of the rabbit.
A flare-like spread of vasodilatation can be demonstrated in the limb skin of the anaesthetised rabbit using laser doppler flowmetry. Spread of dilatation from a small mechanical injury (nicking the skin) extends 5-10 mm. The size and time course of the dilatation are as expected from the low frequency C-nociceptor firing that occurs in response to similar nearby injury. Since C-nociceptors cause significant vasodilator responses at frequencies less than 1 Hz, it is proposed that they may often have a pro-inflammatory action without producing any reflex or sensory effects.
Lynn
B
B
Department of Physiology, University College London, UK.
Shakhanbeh
J
J
D000818:Animals; D001783:Blood Flow Velocity; D006614:Hindlimb; D007700:Kinetics; D009412:Nerve Fibers / Q000502:physiology*; D009450:Neurodermatitis / Q000503:physiopathology*; D009619:Nociceptors / Q000502:physiology*; D011817:Rabbits; D012867:Skin / Q000098:blood supply*; D014664:Vasodilation