A model reaction for the repair of nucleic acids. The repair of thymidine bromohydrins.
Bromohydrins, which were damaged products of thymidines (2, 3, and 4), were repaired with sunlight of heat via a radical mechanism to regenerate the thymidines. A hypothesis for the biological significance of thymidine in DNA is presented.
Harayama
T
T
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Yanada
R
R
Akiyama
T
T
Tanaka
M
M
Fujita
Y
Y
Yoneda
F
F
D004249:DNA Damage; D004260:DNA Repair; D006358:Hot Temperature; D008957:Models, Genetic; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013472:Sunlight; D013936:Thymidine / Q000031:analogs & derivatives*
C054175:thymidine bromohydrin; D013936:Thymidine