Concentration-effect relationships of NSAID.
For the most part, plasma concentrations of nonsteroidal antiinflammatory drugs (NSAID) have not correlated well with assessments of therapeutic response. This disappointing record may largely reflect weaknesses in experimental design. It may also be, however, that concentrations in plasma bear only a distant relationship to those in the inflamed tissues where NSAID presumably act. Elimination kinetics, protein binding, fat solubility, tissue blood flow, and uptake by cells may be determinants of concentration and response in target tissues. These factors are considered as they relate to NSAID concentrations in synovial effusions.
Simkin
P A
PA
Department of Medicine, University of Washington, Seattle 98195.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001168:Arthritis / Q000188:drug therapy; D001692:Biological Transport; D001798:Blood Proteins / Q000378:metabolism; D001808:Blood Vessels / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009994:Osmolar Concentration; D013582:Synovial Fluid / Q000032:analysis; D013583:Synovial Membrane / Q000098:blood supply
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001798:Blood Proteins