Chloroquine absorption in children from polyethylene glycol base suppositories.
Chloroquine phosphate (CP) has been formulated in a suppository base consisting of polyethylene glycol, PEG 1000 and PEG 6000 (7:3) with 0.5% polysorbate 80 included as an absorption promoter. Peak chloroquine blood levels in children (mean body weight 10 kg, age 21 months) were 0.67 +/- 0.08 micrograms/ml (after 200 mg CP) and 1.06 +/- 0.23 micrograms/ml (after 300 mg CP) following rectal administration of the suppositories. Prior to drug administration, the base level chloroquine was 0.30 +/- 0.02 micrograms/ml. Elimination half lives calculated from the rapid phase of log concentration-time curves were 3.3 h (after 200 mg CP) and 2.7 h (after 300 mg CP), respectively. Based on literature evidence the blood levels obtained with the 300 mg CP suppositories would be therapeutic in the management of malaria and rheumatoid disease.
Okor
R S
RS
Department of Pharmaceutics, University of Benin, Nigeria.
Nwankwo
M U
MU
D000042:Absorption; D000285:Administration, Rectal; D001835:Body Weight; D002626:Chemistry, Pharmaceutical; D002675:Child, Preschool; D002738:Chloroquine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D007223:Infant; D011092:Polyethylene Glycols; D013488:Suppositories
D013488:Suppositories; D011092:Polyethylene Glycols; D002738:Chloroquine