title: Identification of a novel oligosaccharide backbone structure with a galactose residue monosubstituted at C-6 in human foetal gastrointestinal mucins.
abstract: An oligosaccharide purified from a major penta- to hexa-saccharide fraction of human meconium glycoproteins has been shown by m.s. and n.m.r. analysis to have a novel backbone structure containing an internal galactose residue monosubstituted at C-6 by N-acetylglucosamine: (Formula: see text). This oligosaccharide may represent a biosynthetic product of a previously unrecognized N-acetylglucosaminyltransferase catalysing formation of a linear GlcNAc beta 1-6Gal sequence.
authors.affiliation: Section of Glycoconjugate Research, Clinical Research Centre, Harrow, U.K.
authors.forename: E F
authors.initials: EF
authors.lastname: Hounsell
authors.forename: A M
authors.initials: AM
authors.lastname: Lawson
authors.forename: J
authors.initials: J
authors.lastname: Feeney
authors.forename: G C
authors.initials: GC
authors.lastname: Cashmore
authors.forename: D P
authors.initials: DP
authors.lastname: Kane
authors.forename: M
authors.initials: M
authors.lastname: Stoll
authors.forename: T
authors.initials: T
authors.lastname: Feizi
mesh_terms: D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006801:Humans; D007231:Infant, Newborn; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008470:Meconium / Q000032:analysis*; D009077:Mucins / Q000032:analysis*; D009844:Oligosaccharides / Q000032:analysis*
chemical_list: D009077:Mucins; D009844:Oligosaccharides