Effects of san-huang-hsieh-hsin-tang on central monoaminergic and GABAergic systems in rats.
In this paper, the effects of San-Huang-Hsieh-Hsin-Tang on central monoaminergic and GABAergic systems were studied in rats. It was found that San-Huang-Hsieh-Hsin-Tang significantly (1) prolonged the period from the onset of clonic to tonic convulsions induced by picrotoxin, (2) prolonged the sleep duration induced by hexobarbital, (3) inhibited central catecholaminergic activity, (4) promoted central GABAergic activity, and (5) decreased the turnovers of central norepinephrine and dopamine.
Chu
C Y
CY
Department of Biochemistry, Chung Shan Medical and Dental College, Taichung, Taiwan.
Chen
H C
HC
Shiow
S J
SJ
Yen
K Y
KY
Hsieh
M T
MT
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced; D012890:Sleep / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D002395:Catecholamines; D004365:Drugs, Chinese Herbal; C042122:san-huang-hsieh-hsin-tang; D005680:gamma-Aminobutyric Acid