title: The effects of muscular exercise on glucose, free fatty acids, alanine and lactate in type I diabetic subjects in relation to metabolic control.
abstract: Metabolic effects of muscular exercise were studied in eleven subjects with type I diabetes mellitus during poor metabolic control, and again during good metabolic control, and in ten healthy control subjects. All the subjects were submitted to a submaximal gradual triangular test on an electrically braked bicycle ergometer; glucose, FFA, alanine and lactate were measured at rest, and after exercise. In poorly controlled patients, glucose and FFA were unchanged after exercise, whereas blood alanine and lactate increased by a percentage similar to that of the controls, and well-controlled diabetic patients. Baseline alanine concentrations were lower and lactate concentrations higher than in the controls and well-controlled patients. After adequate metabolic control was achieved, in the well-controlled diabetic patients a normalization of pre-exercise alanine and lactate levels and a decrease in blood glucose and FFA after exercise was observed.
authors.affiliation: Istituto di Clinica Medica, Università degli Studi di Palermo, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Donatelli
authors.forename: S
authors.initials: S
authors.lastname: Verga
authors.forename: V
authors.initials: V
authors.lastname: Russo
authors.forename: C
authors.initials: C
authors.lastname: Terrizzi
authors.forename: M L
authors.initials: ML
authors.lastname: Bucalo
authors.forename: A
authors.initials: A
authors.lastname: Scarpinato
authors.forename: M
authors.initials: M
authors.lastname: Vaccaro
authors.forename: G
authors.initials: G
authors.lastname: Cerasola
mesh_terms: D000328:Adult; D000409:Alanine / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis*; D002096:C-Peptide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D015444:Exercise; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood*; D008297:Male; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D000409:Alanine