Evidence for autosomal recessive inheritance of progeria (Hutchinson Gilford).
We have studied a boy with progeria (Hutchinson Gilford) born to third cousins. Four other individuals with progeria were born in another consanguineous sibship in the same family. Thus, this disorder can be inherited as an autosomal recessive trait.
Maciel
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Departamento de Genética Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Brazil.
D002648:Child; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D005808:Genes, Recessive; D006801:Humans; D008297:Male; D009030:Mosaicism; D011371:Progeria / Q000235:genetics*