title: [Natural history and development of bone metastasis. Apropos of 429 cases].
abstract: The records of 429 patients seen at the Centre Alexis-Vautrin in 1979 and 1980 with bony metastases were retrospectively reviewed to assess their natural history and survival. Breast was the location of primary lesion in 140 patients (32.6%), lung in 95 patients (22.1%) and prostate in 33 patients (7.7%). The primary tumor was of unknown origin in 42 cases (10.9%). The median survival from time of diagnosis was 5 months. Two and 5-year survival rates were 17.5 and 5.1% respectively. According to the nature of the primary tumor, 2 and 5-year survival periods for bony metastases were 36.4 and 7.9% in breast cancer, 33.3 and 15.2% in prostatic cancer, 4.3 and 2.1% in metastases of unknown origin, 2.1 and 0% in pulmonary carcinoma. Multivariate analysis revealed four factors to be of prognostic significance for survival: the nature of the primary tumor, the absence of local relapse, the disease-free interval and the absence of metastases in other sites. Patients with hormone-sensitive lesions or slowly-growing tumors had a better prognosis.
authors.affiliation: Service de médecine, Centre Alexis-Vautrin, Brabois, Vandoeuvre-les-Nancy, France.
authors.forename: T
authors.initials: T
authors.lastname: Conroy
authors.forename: L
authors.initials: L
authors.lastname: Malissard
authors.forename: D
authors.initials: D
authors.lastname: Dartois
authors.forename: E
authors.initials: E
authors.lastname: Luporsi
authors.forename: J
authors.initials: J
authors.lastname: Stines
authors.forename: C
authors.initials: C
authors.lastname: Chardot
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000401:mortality / Q000556:secondary*; D001943:Breast Neoplasms; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D005260:Female; D005266:Femoral Neoplasms / Q000556:secondary; D006801:Humans; D008175:Lung Neoplasms; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011471:Prostatic Neoplasms; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000556:secondary
vernacular_title: Histoire naturelle et évolution des métastases osseuses. A propos de 429 observations.