In vitro activity of sulbactam/ampicillin and ampicillin against methicillin-sensitive and methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.
Minimum inhibitory concentrations (MICs) of ampicillin and ampicillin + sulbactam (1:1) against 165 strains of Staphylococcus aureus and 72 strains of Staphylococcus epidermidis have been evaluated. The activity of the combination was very good. A concentration of 16 micrograms/ml + 16 micrograms/ml inhibited 96.9% of S. aureus and the 100% of S. epidermidis strains (at the same concentration ampicillin alone inhibited only 55.15% and 56.9% of S. aureus and S. epidermidis strains respectively). Activity against methicillin-resistant S. aureus (14.5%) was poor, whereas against methicillin-resistant S. epidermidis (67.2%) the combination maintained high efficacy.
Fabbri
A
A
II Clinica Malattie Infettive, Ospedale G. Gaslini, Genova, Italy.
Tacchella
A
A
Belli
M L
ML
Losurdo
G
G
D000667:Ampicillin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000494:pharmacology; D008712:Methicillin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D013212:Staphylococcus epidermidis / Q000187:drug effects*; D013407:Sulbactam / Q000494:pharmacology*
D000667:Ampicillin; D008712:Methicillin; D013407:Sulbactam