title: Studies on the neuropsychopharmacological profile of fengabine (SL 79229) in mice.
abstract: The effect of fengabine (a novel benzylidene derivative) on neuropsychopharmacological parameters was investigated in mice. On acute systemic administration, it showed modulatory effects on 1) forced swimming-induced immobility, 2) foot shock-induced aggression, 3) electromaximal shock-induced convulsion, 4) radiant heat-induced nociception and 5) locomotor activity. However, it has no effect on the muscle strength of the animal. The GABAA receptor antagonists reversed its effects on forced swimming-induced immobility and foot shock-induced aggression, implicating a GABAergic involvement in its mechanism of action. But these antagonists failed to reverse its potentiating effect on morphine antinociception, suggesting a possible interaction of the drug with opioid receptors. A potential clinical usefulness of the drug and of GABA agonists in general is commented upon.
authors.affiliation: Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
authors.forename: K O
authors.initials: KO
authors.lastname: Aley
authors.forename: S K
authors.initials: SK
authors.lastname: Kulkarni
mesh_terms: D000374:Aggression / Q000187:drug effects; D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002733:Chlorophenols / Q000494:pharmacology*; D004597:Electroshock; D006380:Helplessness, Learned; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D004856:Postural Balance / Q000187:drug effects
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D000928:Antidepressive Agents; D002733:Chlorophenols; C052028:fengabine