title: Metabolism of homoorientin by human intestinal bacteria.
abstract: As a part of our studies on the metabolism of bioactive compounds from oriental medicines by intestinal flora, homoorientin, a C-glycosylflavonoid, was anaerobically incubated with a human intestinal bacterial mixture. Homoorientin was transformed to 6-C-glucosyleriodictyol, (+/-)-eriodictyol, luteolin, 3,4-dihydroxyphenylpropionic acid, and phloroglucinol. A novel cleavage of the C-glycosyl bond was discovered for the first time by using intestinal bacteria.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hattori
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Shu
authors.forename: A I
authors.initials: AI
authors.lastname: el-Sedawy
authors.forename: T
authors.initials: T
authors.lastname: Namba
authors.forename: K
authors.initials: K
authors.lastname: Kobashi
authors.forename: T
authors.initials: T
authors.lastname: Tomimori
mesh_terms: D001421:Bacteria, Anaerobic / Q000378:metabolism; D005243:Feces / Q000382:microbiology; D005419:Flavonoids / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology*; D047311:Luteolin; D010946:Plants, Medicinal / Q000032:analysis; D013997:Time Factors
chemical_list: D005419:Flavonoids; C057912:homoorientin; D047311:Luteolin