Expression of IgA and secretory component in the normal and in adenocarcinomas of Fallopian tube, endometrium and endocervix.
The occurrence and localization of IgA and secretory components (SC) were examined in the normal and in adenocarcinomas of Fallopian tube, endometrium and endocervix. IgA-containing immunocytes were identified in the stroma of 90% of normal Fallopian tubes. It is suggested that the Fallopian tube may have an immunological function and may, together with the endocervix, constitute the local secretory immune system of the female genital tract. IgA and SC were frequently demonstrated in the cytoplasm and luminal secretion of adenocarcinomas of the endocervix, endometrium and Fallopian tube. This study has shown a decrease in immunoreactivity of SC among poorly differentiated adenocarcinomas but has failed to demonstrate any correlation between the expression of IgA and the degree of differentiation of the tumours. Secretory component appears, therefore, to be more useful than IgA as an indicator of secretory activity and differentiation of adenocarcinomas of the female genital tract.
Lee
Y S
YS
Department of Pathology, National University of Singapore, Republic of Singapore.
Raju
G C
GC
D000230:Adenocarcinoma / Q000032:analysis* / Q000276:immunology / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis; D004715:Endometriosis; D005185:Fallopian Tube Neoplasms / Q000032:analysis / Q000276:immunology / Q000378:metabolism; D005187:Fallopian Tubes / Q000276:immunology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007128:Immunoglobulin Fragments / Q000032:analysis*; D012635:Secretory Component / Q000032:analysis*; D002583:Uterine Cervical Neoplasms / Q000032:analysis / Q000276:immunology / Q000378:metabolism; D014594:Uterine Neoplasms / Q000032:analysis / Q000276:immunology / Q000378:metabolism
D014408:Biomarkers, Tumor; D007070:Immunoglobulin A; D007128:Immunoglobulin Fragments; D012635:Secretory Component