Biochemical diagnosis of genetic disorders of the osseous skeleton.
Genetic diseases of the skeletal system are difficult to accurately diagnose. Changes in the chemical structure of collagen significantly modify the structure of collagen in bone. The ratio of collagen hydration to hydroxylation reflects specific features of the collagen structure. The hypothesis proposes to use this ratio in the diagnosis of diseases of the skeleton.
Papatheofanis
F J
FJ
Department of Orthopaedics, College of Medicine, University of Illinois, Chicago 60680.
D001847:Bone Diseases / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D006801:Humans; D006900:Hydroxylation; D008954:Models, Biological
D003094:Collagen