title: Fluoride reduces the rate of dissolution of bone.
abstract: Recently, fluoride has been used in the treatment of osteoporosis in an attempt to rebuild bone lost due to this disease. Fluoride has been shown to have a profound effect on osteoblasts and bone formation. Studies have shown that synthetic fluorapatite is more stable and less soluble than hydroxyapatite. This study was designed to determine the dissolution properties of bones from rats fed a normal diet versus rats fed a high fluoride diet. Intact and deproteinized bones were dissolved in buffered solutions, containing physiological amounts of inorganic Ca and P, at pH 3.4, 4.4 and 5.4. The data demonstrate that fluoridated bones dissolve slower than normal bones, deproteinized bones dissolve faster than intact bones and that the initial rate of dissolution of fluoridated bone is always significantly lower than that of normal bone. This may help to explain the reduced rate of osteoclastic resorption in patients undergoing fluoride therapy.
authors.affiliation: Pathology Department, University of Toronto, Canada.
authors.forename: M D
authors.initials: MD
authors.lastname: Grynpas
authors.forename: P T
authors.initials: PT
authors.lastname: Cheng
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000187:drug effects; D001842:Bone and Bones / Q000032:analysis; D002118:Calcium / Q000032:analysis; D004032:Diet; D005260:Female; D005459:Fluorides / Q000008:administration & dosage*; D005461:Fluorine / Q000032:analysis; D010024:Osteoporosis / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D005461:Fluorine; D005459:Fluorides; D002118:Calcium