title: Paramagnetic contrast enhancement at 0.02 T: an experimental study using Gd-DOTA in normal and hydronephrotic kidneys.
abstract: Both normal and experimentally hydronephrotic rabbits were imaged at 0.02 T using partial saturation (PS 160/30) and inversion recovery (IR 1000/200/40) sequences. The signal intensity of normal renal medulla and cortex markedly increased after the injection of 0.1 mmol/kg of Gd-DOTA. In the unilateral total hydronephrosis the dilated renal pelvis did not contrast enhance after 15 and 35 min of Gd-DOTA injection. The enhancement pattern was similar in 1- and 3-week-old hydronephrosis. The effect of Gd-DOTA on renal T1 times at 0.02 T was studied using rats. Fifteen minutes after the Gd-DOTA injection (0.1 mmol/kg) the T1 times of excised rat kidneys decreased from 311 to 90 ms. The authors conclude that the enhancement of the MR signal of the kidney by Gd-DOTA at an ultralow magnetic field (0.02 T) is similar to its enhancement at higher fields (greater than 0.15 T).
authors.affiliation: Department of Diagnostic Radiology, University of Turku, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Niemi
authors.forename: H
authors.initials: H
authors.lastname: Paajanen
authors.forename: H
authors.initials: H
authors.lastname: Määttänen
authors.forename: M
authors.initials: M
authors.lastname: Komu
authors.forename: M
authors.initials: M
authors.lastname: Erkintalo
authors.forename: A
authors.initials: A
authors.lastname: Alanen
authors.forename: P B
authors.initials: PB
authors.lastname: Dean
authors.forename: M
authors.initials: M
authors.lastname: Kormano
mesh_terms: D000818:Animals; D003287:Contrast Media; D006571:Heterocyclic Compounds; D006869:Hydronephrosis / Q000473:pathology*; D007668:Kidney / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009942:Organometallic Compounds; D011817:Rabbits; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate