title: Secondary sclerosing cholangitis: an experimental study.
abstract: An experimental study on rabbit sclerosing cholangitis (SC) secondary to direct injection into the biliary tract of the chemical substances commonly employed for intraoperative sterilization of the hydatid cyst content is reported. Among the various substances utilized, 10% formalin and 30% hypertonic solution caused gross and microscopic lesions compatible with less advanced forms of sclerosing cholangitis. The authors present their hypothesis on the development of SC in operated hydatid cysts of the liver.
authors.affiliation: Second Surgical Clinic, University of Rome La Sapienza, Medical School, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pappalardo
authors.forename: F M
authors.initials: FM
authors.lastname: Frattaroli
authors.forename: A
authors.initials: A
authors.lastname: Ioppolo
authors.forename: E
authors.initials: E
authors.lastname: Conti
authors.forename: D
authors.initials: D
authors.lastname: Reggio
authors.forename: G
authors.initials: G
authors.lastname: Di Macco
authors.forename: G
authors.initials: G
authors.lastname: Castrini
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001659:Biliary Tract / Q000000981:diagnostic imaging / Q000473:pathology; D002758:Cholangiography; D015209:Cholangitis, Sclerosing / Q000139:chemically induced*; D005557:Formaldehyde / Q000009:adverse effects*; D007267:Injections; D008297:Male; D011817:Rabbits; D012462:Saline Solution, Hypertonic / Q000009:adverse effects*; D012965:Sodium Chloride / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D012462:Saline Solution, Hypertonic; D005557:Formaldehyde; D012965:Sodium Chloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase