title: Vitamin E intake affects serum thromboxane and tissue essential fatty acid composition in the rat.
abstract: The influence of dietary vitamin E on the composition of essential fatty acids in rat tissue and plasma lipids as well as serum thromboxane B2 was studied. Diets containing deficient (0 mg/kg diet), adequate (100 mg/kg) or supplemental (1,000 mg/kg) vitamin E were fed to young male rats for 10 weeks. The ratio of dihomo-gamma-linolenic acid to arachidonic acid in phospholipids of plasma, liver, and testes was increased in vitamin-E-supplemented rats. Serum thromboxane B2 was increased in vitamin-E-deficient rats. The data support a role for vitamin E in affecting both metabolism of long chain fatty acids, i.e. dihomo-gamma-linolenic acid, and conversion of arachidonic acid to thromboxane A2.
authors.affiliation: Dept. Nutritional Sciences, University of Toronto, Canada.
authors.forename: S C
authors.initials: SC
authors.lastname: Cunnane
mesh_terms: D000818:Animals; D004032:Diet; D005228:Fatty Acids, Essential / Q000032:analysis*; D005527:Food, Fortified; D008297:Male; D010743:Phospholipids / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013929:Thromboxane B2 / Q000097:blood*; D014018:Tissue Distribution; D014810:Vitamin E / Q000008:administration & dosage*; D014811:Vitamin E Deficiency / Q000378:metabolism
chemical_list: D005228:Fatty Acids, Essential; D010743:Phospholipids; D014810:Vitamin E; D013929:Thromboxane B2