Induction of hyperthyroidism in burn patients treated topically with povidone-iodine.
Hyperthyroidism was induced in two burn patients (one a 34-year-old male, with burns covering 80 per cent BSA and the other a 22-year-old female with a 45 per cent BSA burn) by topical treatment with povidone-iodine. Both patients had no history of thyroid disease and their post-burn examination revealed normal thyroid glands. In both patients 1 per cent povidone-iodine was applied onto granulation tissue and a marked increase in circulating thyroid hormones occurred. After topical treatment with povidone-iodine was discontinued circulating thyroid hormones returned to normal values within weeks. In the second patient povidone-iodine treatment had to be repeated again resulting in hyperthyroidism which was also readily reversible.
Rath
T
T
1st Surgical University Clinic, Ludwig Boltzmann Institute of Experimental Plastic Surgery, Vienna, Austria.
Meissl
G
G
D000287:Administration, Topical; D000328:Adult; D002056:Burns / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000009:adverse effects*; D013963:Thyroid Hormones / Q000097:blood
D013963:Thyroid Hormones; D008713:Methimazole; D011206:Povidone-Iodine; D011205:Povidone