[Complete deficiency in the C2 fraction of complement associated with a glomerular nephropathy: apropos of 2 cases].
Two patients with non-systemic idiopathic glomerulonephritis were found to have a complete deficiency of C2, the second component of complement; the clinical course and serological abnormalities are reported in detail. An immunogenetic analysis of the patients of two families was carried out. It was demonstrated that the homozygous C2 deficiency was associated with homozygosity for HLA-A25-B18-DR2-BfS-C4A4-C4B2 haplotype.
Ayed
K
K
Laboratoire d'Immunologie, Faculté de Médecine de Tunis.
Bardi
R
R
Sassi
F
F
Gorgi
Y
Y
Ben Maiz
H
H
Haddad
S
S
Ben Ayed
H
H
D000328:Adult; D003175:Complement C2 / Q000172:deficiency*; D005260:Female; D005921:Glomerulonephritis / Q000235:genetics / Q000276:immunology*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D008297:Male; D010375:Pedigree
D003175:Complement C2; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens
Déficit complet en fraction C2 du complément associé à une néphropathie glomérulaire: à propos de deux observations.