[Dihydro-5,6-imidazo[2,1-b]thiazoles, dihydro-2,3-imidazo[2,1-b]benzothiazoles, analogs of levamisole].
New compounds containing 5,6-dihydro imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro imidazo[2,1-b]thiazole and 2,3-dihydro imidazo[2,1-b]benzothiazole rings, substituted by heterocycles analogue to chromones, were synthesized and screened against three nematodes, in vitro. The results indicate moderate anthelmintic properties, compared to levamisole; nevertheless, some products exhibit a significant degree of activity.
Amarouch
H
H
Département de Chimie Pharmaceutique, Faculté de Pharmacie, Toulouse, France.
Loiseau
P R
PR
Bonnafous
M
M
Caujolle
R
R
Payard
M
M
Loiseau
P M
PM
Bories
C
C
Gayral
P
P
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005370:Filarioidea / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D007978:Levamisole / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000201:enzymology; D009348:Nematoda / Q000187:drug effects; D009559:Nippostrongylus / Q000187:drug effects; D051381:Rats; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors
D000871:Anthelmintics; D007093:Imidazoles; D007978:Levamisole; D013385:Succinate Dehydrogenase
Dihydro-5,6 imidazo[2,1-b]thiazoles, dihydro-2,3 imidazo[2,1-b]benzothiazoles, analogues du levamisole.