title: Juvenile hypocalcemia provokes persistent electroencephalographic change in renally compromised rats.
abstract: In view of the putative involvement of calcium in uremic encephalopathy and the critical importance of this element in juvenile development, we examined the effect of temporary restriction of dietary calcium intake on serum chemistry and the quantitative electroencephalogram (Q.EEG) in unilaterally 3/4 nephrectomized juvenile male Sprague-Dawley rats. Animals were renally infarcted at 22-26 days of age (50-74 g) and placed on one of two isocaloric dietary regimens: powdered normal rat diet (ND, n = 25) or low calcium diet (LCD, n = 8) for 30 days. At this time, ND animals showed normal serum chemistries, whereas LCD rats were hypocalcemic and azotemic with significantly elevated blood urea nitrogen (BUN) and serum creatinine concentrations and reduced renal creatinine clearance values. All animals thereafter received ND for 25-34 further days, during which time chronic Q.EEG electrodes were implanted. At the end of the common ND feeding period, serum chemistry values were equal and normal in both groups. The average theta/alpha ratio (TAR) of the overnight Q.EEG was assessed for 3 days. We found that the TAR of previously LCD animals was significantly elevated compared with ND rats. This indicates an encephalopathic slowing of the background rhythm of these animals. We conclude that, following restoration of a transient uremic and hypocalcemic episode induced by LCD feeding, the Q.EEG background frequency of juvenile renally impaired rats was abnormally slow after 30 days of ND feeding.
authors.affiliation: Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232.
authors.forename: J J
authors.initials: JJ
authors.lastname: Lipman
authors.forename: D L
authors.initials: DL
authors.lastname: White
authors.forename: P L
authors.initials: PL
authors.lastname: Lawrence
authors.forename: P E
authors.initials: PE
authors.lastname: Teschan
mesh_terms: D000375:Aging; D000818:Animals; D001682:Biological Availability; D001806:Blood Urea Nitrogen; D002136:Calcium, Dietary / Q000008:administration & dosage*; D003404:Creatinine / Q000097:blood; D004569:Electroencephalography; D006801:Humans; D006996:Hypocalcemia / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D007674:Kidney Diseases / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D010710:Phosphates / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002136:Calcium, Dietary; D010710:Phosphates; D003404:Creatinine