title: A general approach to selection of multiple cubic volume elements using the ISIS technique.
abstract: The ISIS method is used regularly for the selection of a single cubic volume of tissue for in vivo investigation by high-resolution NMR spectroscopy. This technique has been extended on a theoretical basis to include the simultaneous selection of a number of cubes, the signals from which can be either assessed individually or in certain circumstances coadded to produce improvement in signal-to-noise ratio. The modification requires additional selective RF pulses in the spatial encoding prepulse period, and spatially localized spectra are produced by addition and subtraction of NMR signals in a manner similar to the original ISIS technique.
authors.affiliation: Department of Physics, University of Nottingham, United Kingdom.
authors.forename: R J
authors.initials: RJ
authors.lastname: Ordidge
authors.forename: R M
authors.initials: RM
authors.lastname: Bowley
authors.forename: G
authors.initials: G
authors.lastname: McHale
mesh_terms: D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*