Spontaneous expression of fra(10)(q25) in bone marrow from a patient with agranulocytosis.
We report on the spontaneous expression of fra(10)(q25) in bone marrow from a patient with agranulocytosis. Expression of this fragile site in both bone marrow and leukocytes was enhanced by bromodeoxyuridine (BrdU), while folic-acid-deficient medium enhanced the expression of fra(10)(q25) only in leukocytes. Variability in the expression of fra(10)(q25) in bone marrow and leukocyte cultures over an 18-month period was also found.
Haney
S M
SM
Department of Medical Genetics, Indiana University School of Medicine, Indianapolis 46223.
Butler
F O
FO
Heerema
N A
NA
D000328:Adult; D000380:Agranulocytosis / Q000235:genetics*; D001973:Bromodeoxyuridine; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002879:Chromosomes, Human, Pair 10 / Q000648:ultrastructure*; D005260:Female; D005492:Folic Acid; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007621:Karyotyping; D007962:Leukocytes / Q000648:ultrastructure*; D013997:Time Factors
D005492:Folic Acid; D001973:Bromodeoxyuridine