Erythromycin-induced immune hemolytic anemia.
A 3-year-old female receiving Pediazole (erythromycin ethylsuccinate and sulfisoxazole) for tonsillitis and otitis media developed severe hemolytic anemia. No serum drug-dependent antibodies could be demonstrated with an in vitro 'immune-complex' method using Pediazole, pure erythromycin ethylsuccinate or pure sulfisoxazole. However, a method using red cells coated with erythromycin base showed in vitro lysis of the erythromycin-coated red cells. This is only the second case of immune hemolytic anemia associated with erythromycin and the first where in vitro drug-dependent hemolysis was demonstrable.
Nance
S J
SJ
American Red Cross Blood Services, Los Angeles-Orange Counties Region, Calif.
Ladisch
S
S
Williamson
T L
TL
Garratty
G
G
D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000276:immunology; D002675:Child, Preschool; D004912:Erythrocytes / Q000187:drug effects; D004917:Erythromycin / Q000009:adverse effects*; D005260:Female; D006801:Humans
D004917:Erythromycin