A morphometric analysis of synaptic vesicle distributions.
Synaptic vesicle populations have been morphometrically analyzed for size and density. Populations composed of a single size class of vesicles are represented by normal (Gaussian) or positive (log-normal) skew histograms. Populations with multiple size classes generate negative (left) skew distributions. Fixatives containing aldehydes differentially affect these distribution patterns but vesicles are able to withstand tonic effects over a wide range. Reader bias' contribute the most error in the data-collecting process. But despite this, the sizing of vesicle populations can be accomplished with great accuracy. Vesicle density computations, on the other hand, vary over a wide range and are of less value for comparative purposes.
Fox
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Max-Planck-Institut für biophysikalische Chemie, Göttingen, F.R.G.
D000818:Animals; D004557:Electric Organ / Q000648:ultrastructure*; D005404:Fixatives; D008854:Microscopy, Electron; D012860:Skates, Fish; D013572:Synaptic Vesicles / Q000145:classification* / Q000187:drug effects / Q000648:ultrastructure; D014101:Torpedo
D005404:Fixatives