title: Experimental comparative study on myelotoxicity of 4'-deoxy-4'-I-doxorubicin and of doxorubicin.
abstract: 4'-Deoxy-4'-I-doxorubicin (I-Dx) is 1.5-2 times more potent than doxorubicin (Dx) on some mice tumors and does not seem to be cardiotoxic. A comparison was made of the effects of both anthracyclines on mice bone marrow hemopoietic progenitors (CFU-S, GM-CFC) and peripheral blood cells. The experimental model is based on dose survival and time survival curves following single or repeated (1 weekly administration for 4 weeks) doses. Results indicate slightly higher sensitivity of assayed populations to I-DX than to Dx.
authors.affiliation: Istituto Scientifico di Medicina Interna, Università di Genova, Italia.
authors.forename: R
authors.initials: R
authors.lastname: Lerza
authors.forename: G
authors.initials: G
authors.lastname: Bogliolo
authors.forename: M
authors.initials: M
authors.lastname: Mencoboni
authors.forename: A
authors.initials: A
authors.lastname: Saviane
authors.forename: C
authors.initials: C
authors.lastname: Muzzulini
authors.forename: I
authors.initials: I
authors.lastname: Pannacciulli
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D012156:Reticulocytes / Q000187:drug effects
chemical_list: D004317:Doxorubicin; C030851:esorubicin