Binding of drugs to end-line filters: a study of four commonly administered drugs in intensive care units.
The binding of diazepam, digoxin, dopamine and fentanyl to different 0.2 microns end-line filters was investigated under simulated infusion conditions. All the drugs were diluted in either 5% dextrose or 0.9% NaCl infusion fluid. For digoxin and diazepam a marked reduction in the amount of drug delivered to the patient in the first 20-60 min of infusion is observed. For dopamine, the drug loss was less pronounced and no fentanyl was absorbed to the filters during the infusion experiment.
De Muynck
C
C
Laboratory of Pharmaceutical Technology, State University of Gent, Belgium.
De Vroe
C
C
Remon
J P
JP
Colardyn
F
F
D000042:Absorption; D003975:Diazepam; D004077:Digoxin; D004298:Dopamine; D005283:Fentanyl; D005374:Filtration / Q000295:instrumentation*; D007262:Infusions, Intravenous / Q000295:instrumentation*; D007362:Intensive Care Units
D004077:Digoxin; D003975:Diazepam; D005283:Fentanyl; D004298:Dopamine