A new type of transforming growth factor-beta, TGF-beta 3.
A new type of TGF-beta, TGF-beta 3, has been identified by cDNA characterization. The amino acid sequence of mature TGF-beta 3 and its precursor has been derived from porcine and human cDNA sequences. The human TGF-beta 3 gene is spread over seven exons as in the case of the TGF-beta 1 gene. Comparison with TGF-beta 1 and -beta 2 indicates a strong conservation of the mature sequences, but a relaxed homology in the precursor segments. TGF-beta 3 mRNA is mainly expressed in cell lines from mesenchymal origin, suggesting a biological role different from the other TGFs-beta.
Derynck
R
R
Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080.
Lindquist
P B
PB
Lee
A
A
Wen
D
D
Tamm
J
J
Graycar
J L
JL
Rhee
L
L
Mason
A J
AJ
Miller
D A
DA
Coffey
R J
RJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005796:Genes; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D013552:Swine; D015291:Transforming Growth Factors / Q000145:classification* / Q000235:genetics
D011498:Protein Precursors; D012333:RNA, Messenger; D015291:Transforming Growth Factors; D004247:DNA