[Prevention of osteoporosis in rats by administration of xydiphone before and during hypokinesia].
During 7 days prior to hypokinesia male Wistar rats were given 10 mg/kg xydiphone to ensure and additional bone pool. Then the rats were exposed to 32-day hypokinesia during which they were injected with 1 or 5 mg/kg xydiphone. Drug administration before hypokinesia prevented spongy bone losses in long bones, torso and pelvic bones. Xydiphone injections before and during hypokinesia not only prevented osteoporosis but also led to bone mass increase above the normal level. It is assumed that xydiphone stimulates the involvement of cells-precursors in the new bone formation. This method of osteoporosis prophylaxis can be recommended for space medicine application.
Shvets
V N
VN
Pankova
A S
AS
Kabitskaia
O E
OE
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology; D002452:Cell Count / Q000187:drug effects; D004164:Diphosphonates / Q000008:administration & dosage*; D012968:Etidronic Acid; D008297:Male; D010006:Osteoblasts / Q000187:drug effects / Q000473:pathology; D010010:Osteoclasts / Q000187:drug effects / Q000473:pathology; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control*; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000473:pathology*
D004164:Diphosphonates; D012968:Etidronic Acid
Profilaktika osteoporoza ksidifonom, vvodimym krysam do i vo vremia gipokinezii.