Localization of the gene encoding human factor V to chromosome 1q21-25.
The gene encoding human coagulation Factor V (FV), one of the cofactors in the blood clotting process, has been mapped to chromosome 1 by both Southern hybridization to DNA from human-hamster somatic cell hybrids and in situ hybridization. The whole plasmid pUC3A containing a 1.5-kb cDNA sequence for FV was 32P-labeled for Southern analysis and 3H-labeled for in situ hybridization to metaphase chromosomes. The results localized the FV gene to the region of 1q21-25.
Wang
H
H
Department of Human Genetics, University of Manitoba, Winnipeg, Canada.
Riddell
D C
DC
Guinto
E R
ER
MacGillivray
R T
RT
Hamerton
J L
JL
D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D003001:Cloning, Molecular; D006224:Cricetinae; D004247:DNA / Q000235:genetics; D005165:Factor V / Q000235:genetics*; D005796:Genes; D006801:Humans; D006822:Hybrid Cells / Q000166:cytology; D009693:Nucleic Acid Hybridization
D005165:Factor V; D004247:DNA