Acute release of catecholamines on circulating blood cell adrenoceptors and metabolic indices in dog.
The effects of acute release of endogenous catecholamines on both platelet alpha 2 and leukocyte beta adrenoreceptors and metabolic indices (glucose and free fatty acids) were investigated in dogs by means of a model of neurogenic hypertension following acute sinoaortic denervation (ASAD). Despite the marked increase in catecholamine levels (+4.2-fold for noradrenaline and 16.7-fold for adrenaline, for example, at minute 45 following ASAD) and in glucose plasma levels, and the significant decrease in free fatty acid plasma levels, no change in platelet alpha 2 or leukocyte beta adrenoreceptor binding sites (number as well as affinity) was observed during the whole experiment. It is suggested that the number of platelet alpha 2- and leukocyte beta-adrenoreceptors is not submitted to short-term regulation, at least by endogenous catecholamines in dogs.
Valet
P
P
Laboratoire de Pharmacologie Médicale et Clinique, INSERM U 317, Faculté de Médecine, Toulouse, France.
Damase-Michel
C
C
Taouis
M
M
Montastruc
J L
JL
Cotonat
J
J
Montastruc
P
P
D000818:Animals; D001773:Blood Cells / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006728:Hormones / Q000097:blood; D066298:In Vitro Techniques; D020120:Iodocyanopindolol; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D010869:Pindolol / Q000031:analogs & derivatives; D011941:Receptors, Adrenergic / Q000097:blood*; D012849:Sinoatrial Node / Q000502:physiology; D015016:Yohimbine / Q000097:blood
D001786:Blood Glucose; D002395:Catecholamines; D005230:Fatty Acids, Nonesterified; D006728:Hormones; D011941:Receptors, Adrenergic; D015016:Yohimbine; D020120:Iodocyanopindolol; D010869:Pindolol