title: Chronic administration of nerve growth factor and other neurotrophic factors to the brain.
abstract: Intracerebral chronic administration of nerve growth factor (NGF) is able to counteract age-related cholinergic dysfunction. This finding suggests that intracerebral administration of neurotrophic factors may become a generally valuable approach when attempting to ameliorate age-related neuronal deficits in experimental animals and humans. This commentary briefly discusses possible strategies for the development of such "neurotrophic factor treatments."
authors.affiliation: Department of Neurology, University of Miami, FL 33101.
authors.forename: F
authors.initials: F
authors.lastname: Hefti
authors.forename: B
authors.initials: B
authors.lastname: Knusel
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D009414:Nerve Growth Factors / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D009414:Nerve Growth Factors