Climbing behavior permits in vivo assessment of pre- and postsynaptic extrapyramidal dopaminergic function in mice.
The natural tendency of mice to climb has been investigated in this study as an index of extrapyramidal dopaminergic function. Depending on dose, apomorphine reduced (low dose range; presynaptic dopamine receptor agonism) or increased (high dose-range; postsynaptic dopamine receptor agonism) climbing activity with respect to spontaneous basal levels of such activity in Swiss-Webster mice. We report also an increase in apomorphine-induced enhancement of vertical climbing activity in mice withdrawing from the acute effects of cesium chloride. Spontaneous climbing activity in mice could reflect dynamic extrapyramidal motor tone, upon which voluntary motor activity is superimposed and which, in humans, is adversely affected in motor disorders like parkinsonism.
Pinsky
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Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg.
Brockhausen
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Dua
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Bose
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R
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D002586:Cesium / Q000494:pharmacology; D002712:Chlorides; D004298:Dopamine / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology
D002712:Chlorides; D011954:Receptors, Dopamine; D002586:Cesium; C028019:cesium chloride; D001058:Apomorphine; D004298:Dopamine