Selective concentration of anti-Purkinje cell antibody in the CSF of two patients with paraneoplastic cerebellar degeneration.
An anti-Purkinje cell antibody (APCA) was found in serum and CSF of 2 patients with paraneoplastic cerebellar degeneration (PDC) and breast carcinoma. Integrity of the blood-brain barrier (BBB) was normal in one patient and slightly damaged in the other. In both patients CSF IgG index was normal, but CSF/serum APCA ratio and CSF IgG APCA index were elevated suggesting that a selective concentration of the APCA in CSF occurs in patients with PCD. This feature supports the hypothesis that APCA may play a role in the pathogenesis of PCD.
Graus
F
F
Department of Neurology, Hospital Clinic i Provincial, Barcelona, Spain.
Segurado
O G
OG
Tolosa
E
E
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000134:cerebrospinal fluid*; D001812:Blood-Brain Barrier; D001943:Breast Neoplasms / Q000276:immunology*; D002524:Cerebellar Ataxia / Q000276:immunology; D002526:Cerebellar Diseases / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D010257:Paraneoplastic Syndromes / Q000276:immunology*; D011689:Purkinje Cells / Q000276:immunology*
D001323:Autoantibodies; D007074:Immunoglobulin G