Nd:YAG laser-induced hyperthermia in a mouse tumor model.
Hyperthermic tumor response induced by 1,064-nm radiation from an Nd:YAG laser was investigated in DBA/2J female mice bearing the SMT-F mammary carcinoma. The measured temperature-depth profiles indicate that hyperthermic temperatures can be achieved in tumors ranging from 3 to 8 mm thick at power inputs on the order of 1 W. For small tumors, a 5-week complete response rate exceeding 50% required 45 minutes at 45.0 degrees C. Control of large tumors (6-8 mm thick) was not achieved. The observed tumor response rates are consistent with semiempirical time-temperature relations based on other heating modalities.
Waldow
S M
SM
Wenske Laser Center, Ravenswood Hospital Medical Center, Chicago.
Morrison
P R
PR
Grossweiner
L I
LI
D000818:Animals; D002277:Carcinoma / Q000628:therapy*; D003131:Combined Modality Therapy; D006979:Hyperthermia, Induced / Q000379:methods*; D053685:Laser Therapy; D008325:Mammary Neoplasms, Experimental / Q000628:therapy*; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D010778:Photochemotherapy; D013817:Thermography