Neutralizing response of rabbits to an experimental rubella subunit vaccine made from immunostimulating complexes.
The purpose of this study was to evaluate experimentally the immunogenicity in rabbits of rubella subunits adsorbed to the adjuvant Quil A. The adsorbed viral proteins form structurally defined ImmunoStimulating COMplexes (ISCOMs). Rubella ISCOMs were tested for their capacity to induce neutralizing and hemagglutination-inhibiting antibodies, in comparison with a commercial live attenuated vaccine. Rubella ISCOMs were as efficient as the live vaccine in inducing neutralizing and hemagglutination inhibiting antibodies, suggesting the possibility of developing an ISCOMs subunit vaccine.
Trudel
M
M
Centre de recherche en virologie, Université du Québec, Ville de Laval, Canada.
Nadon
F
F
Séguin
C
C
Payment
P
P
D000276:Adjuvants, Immunologic; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D006385:Hemagglutination Inhibition Tests; D015151:Immunoblotting; D008854:Microscopy, Electron; D009500:Neutralization Tests; D011817:Rabbits; D012411:Rubella Vaccine / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology; D014764:Viral Proteins / Q000032:analysis / Q000648:ultrastructure
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D012411:Rubella Vaccine; D014613:Vaccines, Attenuated; D014764:Viral Proteins