Myoclonic activity associated with cefmetazole, with a review of neurotoxicity of cephalosporins.
We reported a case of a 66-year-old female with uremia who developed myoclonic activity after administration of cefmetazole (4g/2 days). Curiously, the level of the antibiotics (236 micrograms/ml) in the cerebrospinal fluid (CSF) was higher than that in the blood (103 micrograms/ml). Myoclonic activity faded away after cessation of the antibiotics. This is the first case reported developing neurotoxicity associated with intravenous administration of cefmetazole. In addition, the curious pharmacokinetic dynamics of cephalosporin in uremia is discussed.
Uchihara
T
T
Department of Internal Medicine, Asahi General Hospital, Chiba, Japan.
Tsukagoshi
H
H
D000368:Aged; D015311:Cefmetazole / Q000008:administration & dosage / Q000009:adverse effects*; D002511:Cephalosporins / Q000009:adverse effects* / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D009207:Myoclonus / Q000139:chemically induced*; D014511:Uremia / Q000134:cerebrospinal fluid
D002511:Cephalosporins; D015311:Cefmetazole