[The acute hemorheologic effect of calcium dobesilate].
In a series 40 subjects without manifest vascular disorders received 1000 mg Calcium dobesilate (Doxium). Before and 3 hours after application the viscoelasticity of whole blood as well as plasma viscosity and the hematocrit were determined. The statistical analysis was performed by Wilcoxon-test. The viscosity of whole blood and the hematocrit decreased with a significance of p less than or equal to 0.001, whereas the elasticity decreased in a significance manner of p less than or equal to 0.01. Plasma viscosity remained uncharged. The results show an effect of hemodilution, which could be very important for treatment of hyperviscosity.
Költringer
P
P
Krankenhaus der Barmherzigen Brüder, Graz-Eggenberg.
Eber
O
O
Klima
G
G
Langsteger
W
W
Wakonig
P
P
Lind
P
P
Rothlauer
W
W
D000328:Adult; D001557:Benzenesulfonates / Q000494:pharmacology*; D001809:Blood Viscosity / Q000187:drug effects*; D002123:Calcium Dobesilate / Q000494:pharmacology*; D005260:Female; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D012212:Rheology
D001557:Benzenesulfonates; D002123:Calcium Dobesilate
Der hämorheologische Akuteffekt von Kalziumdobesilat.