title: Risk of myocardial ischaemia during anaesthesia in treated and untreated hypertensive patients.
abstract: Hypertensive patients were monitored for myocardial ischaemia during anaesthesia and surgery with the V5 lead of a standard electrocardiograph. Myocardial ischaemia was detected in 11 of 39 untreated hypertensive patients and in four of seven receiving therapy with a diuretic, but in none of 44 receiving atenolol. Fourteen of the atenolol-treated patients were receiving the drug on a long-term basis and the remaining 30 were treated acutely only on the morning of surgery. When myocardial ischaemia was observed, it was always associated with noxious stimulation and tachycardia, but a conspicuous increase in arterial pressure was not usually present. We conclude that myocardial ischaemia is prevalent during anaesthesia in untreated hypertensive patients, and that pretreatment with atenolol, but not diuretics, provides prophylaxis.
authors.affiliation: Department of Anesthesiology, Columbia University, College of Physicians & Surgeons, New York, NY 10032.
authors.forename: J G
authors.initials: JG
authors.lastname: Stone
authors.forename: P
authors.initials: P
authors.lastname: Foëx
authors.forename: J W
authors.initials: JW
authors.lastname: Sear
authors.forename: L L
authors.initials: LL
authors.lastname: Johnson
authors.forename: H J
authors.initials: HJ
authors.lastname: Khambatta
authors.forename: L
authors.initials: L
authors.lastname: Triner
mesh_terms: D000758:Anesthesia / Q000009:adverse effects*; D001262:Atenolol / Q000627:therapeutic use; D003327:Coronary Disease / Q000209:etiology* / Q000517:prevention & control; D004232:Diuretics / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007442:Intubation, Intratracheal / Q000009:adverse effects; D012307:Risk Factors; D013514:Surgical Procedures, Operative
chemical_list: D004232:Diuretics; D001262:Atenolol