title: Drugs, including alcohol, that act as risk factors for cataract, and possible protection against cataract by aspirin-like analgesics and cyclopenthiazide.
abstract: A case-control study of cataract in Oxfordshire explored the risks and benefits associated with a variety of drugs. Steroids including the diuretic spironolactone, nifedipine, heavy smoking, and beer drinking were associated with a raised risk. On the other hand aspirin-like analgesics (paracetamol, ibuprofen, aspirin, etc. appeared to protect against cataract. Cyclopenthiazide appeared to provide a similar protection.
authors.affiliation: Nuffield Laboratory of Ophthalmology, University of Oxford.
authors.forename: J J
authors.initials: JJ
authors.lastname: Harding
authors.forename: R
authors.initials: R
authors.lastname: van Heyningen
mesh_terms: D000368:Aged; D000428:Alcohol Drinking; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002386:Cataract / Q000139:chemically induced / Q000209:etiology* / Q000517:prevention & control; D003518:Cyclopenthiazide / Q000627:therapeutic use*; D004232:Diuretics / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use*; D013256:Steroids / Q000009:adverse effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D013256:Steroids; D009543:Nifedipine; D003518:Cyclopenthiazide