title: Increased (L+)-lactic acid production in lysozyme-inactivated suspensions of human dental plaque.
abstract: The effect of lysozyme-inactivation on L(+)-lactic acid (LA) production in dental plaque suspensions was evaluated. From 10 children 24-h plaque was collected and lysozyme activity inhibited by addition of goat antiserum to human lysozyme. Acid production was stimulated by addition of glucose. The results showed significantly increased LA levels (50-150%) in lysozyme-inactivated plaque suspensions from 8 of the subjects compared to untreated controls. The increase in acid production activity was not related to plaque lysozyme levels. The findings indicate that the presence of lysozyme may be limiting on acid production in the early dental plaque.
authors.affiliation: Department of Pedodontics, Karolinska Institute, Huddinge University Hospital, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Twetman
authors.forename: G
authors.initials: G
authors.lastname: Dahllöf
authors.forename: L
authors.initials: L
authors.lastname: Lindqvist
mesh_terms: D000293:Adolescent; D000418:Albumins / Q000494:pharmacology; D002648:Child; D003773:Dental Plaque / Q000201:enzymology / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007106:Immune Sera; D007536:Isomerism; D007773:Lactates / Q000096:biosynthesis*; D019344:Lactic Acid; D009113:Muramidase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000418:Albumins; D007106:Immune Sera; D007773:Lactates; D019344:Lactic Acid; D009113:Muramidase; D005947:Glucose