Pancreatic and biliary excretion of camostat in dogs.
It has been reported that camostat (Foy-305), a synthetic proteinase inhibitor, is excreted into the biliary-pancreatic juice in rats. To confirm whether camostat is excreted into bile or pancreatic juice, camostat (5 mg/kg/h) was given intravenously to dogs with pancreatic or biliary fistulae. Camostat and its active metabolite (Foy-251) in bile and pancreatic juice were measured by high-performance liquid chromatography (HPLC) and by their trypsin-inhibitory activity. Camostat did not alter the exocrine pancreatic secretion of fluid, bicarbonate, protein or trypsin stimulated by secretin (1 Crick-Harper-Raper unit/kg/h) and cerulein (50 ng/kg/h). Camostat and its active metabolite were detected in bile by HPLC and trypsin-inhibitory activity (the mean excretion rate was 1.3% of the intravenous dose of camostat), but they were not detectable in pancreatic juice. In conclusion, camostat and its active metabolite were excreted into bile but not into pancreatic juice.
Kitagawa
M
M
Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Hayakawa
T
T
Kondo
T
T
Shibata
T
T
Sugimoto
Y
Y
D000818:Animals; D001646:Bile / Q000378:metabolism*; D002108:Ceruletide / Q000008:administration & dosage; D004285:Dogs; D004952:Esters; D016670:Gabexate / Q000031:analogs & derivatives*; D006146:Guanidines / Q000493:pharmacokinetics* / Q000494:pharmacology; D008657:Metabolic Clearance Rate; D010189:Pancreatic Juice / Q000378:metabolism*; D012633:Secretin / Q000008:administration & dosage; D012636:Secretory Rate / Q000187:drug effects
D004952:Esters; D006146:Guanidines; C034532:camostat; D012633:Secretin; D016670:Gabexate; D002108:Ceruletide