title: [The quantitative determination of dihydralazine and selected metabolites in man].
abstract: Dihydralazine and its metabolites were estimated in the steady-state in 9 hypertonic patients by gas chromatography. Serum levels of both dihydralazine and metabolites were very low and particularly below the detection limit. In urine and faeces about half of the dose was found mainly as metabolites, 2/3 of this in faeces. Acid labile hydrazones of dihydralazine (about 6% of the dose), primary acetylated and primary oxidized metabolites (both about 20%) were identified as main metabolites. Secondary metabolites (hydrazones, acetylated and oxidized products) were measured, too.
authors.affiliation: Institut für Klinische Pharmakologie, Ernst-Moritz-Arndt-Universität Greifswald.
authors.forename: T
authors.initials: T
authors.lastname: Schneider
authors.forename: W
authors.initials: W
authors.lastname: Siegmund
authors.forename: M
authors.initials: M
authors.lastname: Zschiesche
authors.forename: R
authors.initials: R
authors.lastname: Kallwellis
mesh_terms: D001711:Biotransformation; D002849:Chromatography, Gas; D004078:Dihydralazine / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D005243:Feces / Q000032:analysis; D006801:Humans; D006830:Hydralazine / Q000031:analogs & derivatives*; D006835:Hydrazones / Q000032:analysis
chemical_list: D006835:Hydrazones; D006830:Hydralazine; D004078:Dihydralazine
vernacular_title: Zur quantitativen Bestimmung von Dihydralazin und ausgewählter Metabolite beim Menschen.