title: Clinical pharmacology of polyestradiol phosphate.
abstract: The results of the present studies demonstrate that intramuscular injections of polyestradiol phosphate (PEP) produce not only considerably increased estrogen concentration in plasma but also maintain the same estrone/estradiol ratio as in normal men. Monthly injections of PEP produce persistent elevation of the plasma estradiol levels throughout the dose interval, and rising PEP doses produce proportionately increasing steady-state plasma concentrations of estradiol. The steady-state plasma concentrations of testosterone are reduced to 45, 25, and 15% of the pretreatment concentrations after treatment every fourth week with 80, 160, and 240 mg PEP, respectively.
authors.affiliation: Department of Pharmacokinetics, Pharmacia LEO Therapeutics AB, Helsingborg, Sweden.
authors.forename: P O
authors.initials: PO
authors.lastname: Gunnarsson
authors.forename: B J
authors.initials: BJ
authors.lastname: Norlén
mesh_terms: D004958:Estradiol / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D045166:Estradiol Congeners / Q000494:pharmacology*; D006801:Humans; D008297:Male; D013739:Testosterone / Q000097:blood
chemical_list: D045166:Estradiol Congeners; D013739:Testosterone; D004958:Estradiol; C008958:polyestradiol phosphate