[Induction of chemiluminescence of human granulocytes by monocyte factors from patients with chronic polyarthritis and arthrosis].
The supernatant of peripheral blood monocytes, cultured with autologous sera from patients with rheumatoid arthritis, stimulates healthy human granulocytes to significantly elevated chemiluminescence (p = 0.05) compared with supernatants of monocytes from osteoarthritic patients or healthy volunteers. Cultures without autologous sera or with heat-inactivated sera demonstrate this effect less significantly (p = 0.05). The peak chemiluminescence is slightly correlated with the titer of rheumatoid factor (r = 0.42 in latex fixation, r = 0.45 in the Waaler-Rose test). The elevated release of monokines, especially interleukin I from monocytes of rheumatoid arthritis patients triggered by rheumatoid factors, immunocomplexes, complement compounds and other serum factors, may explain the phenomenon.
Meske
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Abtl. Rheumatologie und klinische Immunologie, Medizinische Universitätskliniken, Freiburg.
Bänziger
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D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002478:Cells, Cultured; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D008163:Luminescent Measurements; D009000:Monocytes / Q000276:immunology*; D010003:Osteoarthritis / Q000276:immunology*; D012217:Rheumatoid Factor / Q000097:blood
D012217:Rheumatoid Factor
Chemilumineszenzinduktion humaner Granulozyten durch Monozyten-Faktoren von Patienten mit chronischer Polyarthritis und Arthrose.