title: Discovery of methoxyacetylcarbamide in the urine of normal adults and phenylketonuric children.
abstract: In order to study metabolic distinctions in phenylketonuria, urinary metabolites in the form of trimethylsilyl derivatives have been characterized by high resolution gas chromatography and mass spectrometry. A previously unknown metabolite has been found in the urine of some untreated phenylketonuric infants between 2 and 5 yr of age. The metabolite was absent in healthy children of the same age. The metabolite appeared to be present in the urine of apparently healthy adults (25-32 yr old). The metabolite was identified as methoxyacetylcarbamide on the basis of mass fragmentation analysis and compared with synthetic methoxyacetylcarbamide. Their retention times and mass spectra coincided.
authors.affiliation: Institute of Molecular Genetics, USSR Academy of Sciences, Moscow.
authors.forename: A G
authors.initials: AG
authors.lastname: Antoshechkin
authors.lastname: Tatur VYu
authors.forename: L A
authors.initials: LA
authors.lastname: Maximova
mesh_terms: D000328:Adult; D002675:Child, Preschool; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D010661:Phenylketonurias / Q000652:urine*; D014508:Urea / Q000031:analogs & derivatives* / Q000652:urine
chemical_list: C059056:methoxyacetylcarbamide; D014508:Urea