Plasma somatomedin-C levels in systemic sclerosis.
We have measured the plasma levels of somatomedin-C (SM-C) or insulin-like growth factor I (IGF-I) in 13 patients with progressive systemic sclerosis (PSS) and age and sex matched healthy controls. We found the plasma SM-C levels to be within normal limits in all the patients. Thus, if somatomedin-C plays a role in the pathogenesis of PSS, it is more likely to be at the fibroblast receptor level or in the synthetic response of fibroblasts to SM-C.
Rothe
M J
MJ
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Florida 33101.
Altman
R D
RD
Falanga
V
V
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000097:blood*; D013002:Somatomedins / Q000097:blood*
D013002:Somatomedins; D007334:Insulin-Like Growth Factor I