Potential CNS active agents. II--Studies of 4(3H)-quinazolinones.
Some new 2-carbamoylmethylthio- and 2-(omega-dimethylamino-alkyl)thio-3-aryl-7-chloro-4(3H)-quinazolinones have been prepared from 2-thio-3-aryl-7-chloro-4(3H)-quinazolinones as the key intermediate. Five of the synthetic compounds were screened for their CNS activities on mice and found to be either CNS depressants or stimulants.
Lakhan
R
R
Department of Chemistry, Banaras Hindu University, Varanasi, India.
Singh
R L
RL
D000818:Animals; D002491:Central Nervous System Agents / Q000138:chemical synthesis*; D051379:Mice; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D002491:Central Nervous System Agents; D011799:Quinazolines