Immunostimulating staphylococcal lipoteichoic acid prevents pulmonary tumor colonization in BALB/c-mice.
Immunostimulating and antineoplastic activities of staphylococcal lipoteichoic acid (LTA) were studied in Balb/c-mice. Systemic administration of LTA (1 mg or 2 mg i. p., 7 and 4 days prior to challenge) significantly enhanced chemiluminescence response of peritoneal macrophages (p less than 0.0125) and induced enlargement of the spleen (p less than 0.025) as compared to non-treated controls. In vivo the number of lung colonies was significantly lower (p less than 0.0125) in LTA-treated mice 14 days after challenge with L-1 sarcoma cells.
Ohshima
Y
Y
Institute of Hygiene, University of Cologne, Köln.
Ko
H L
HL
Beuth
J
J
Pulverer
G
G
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D008070:Lipopolysaccharides / Q000276:immunology* / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000517:prevention & control*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012513:Sarcoma, Experimental / Q000517:prevention & control*; D013154:Spleen / Q000187:drug effects; D013210:Staphylococcus; D013682:Teichoic Acids / Q000276:immunology* / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid