Alleviation of scopolamine amnesia by different retrieval enhancing treatments.
Mice were trained in a one-way active avoidance task to a criterion of 9/10 avoidances. Immediately following training they were injected with scopolamine hydrochloride (1 mg/kg SC) or with saline. Retention was assessed 3 days after training by 5 test trials on which the UCS was not present. Thirty min prior to the test, groups were injected with different doses of arecoline, d-amphetamine sulphate or with saline. Other scopolamine-treated mice were exposed to the CS or the UCS 24 hr prior to the test. The scopolamine-induced amnesia was attenuated by both 0.5 and 1.0 mg/kg arecoline and by 2.0 mg/kg d-amphetamine. Retention was also improved by exposure to the CS and the UCS. These data show that scopolamine amnesia can be alleviated by treatments which activate retrieval processes.
Quartermain
D
D
Department of Neurology, New York University School of Medicine.
Leo
P
P
D000647:Amnesia / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D012016:Reference Values; D012601:Scopolamine
D001115:Arecoline; D012601:Scopolamine; D003913:Dextroamphetamine