title: Chromosomal mapping of lysosomal enzyme structural genes in the domestic cat.
abstract: A panel of 42 rodent x cat somatic cell hybrids has been used to assign seven structural genes for lysosomal enzymes to specific chromosomes in the domestic cat. The assignments include alpha-glucosidase (GANAB) to chromosome D1, alpha-galactosidase (GLA) to the X chromosome, beta-galactosidase 1 (GLB1) to chromosome B3, beta-glucuronidase (GUSB) to chromosome E3, alpha-mannosidase A (MANA) to chromosome B3, alpha-L-fucosidase (FUCA) to chromosome C1, and hexosaminidase A (HEXA) to chromosome B3. In all cases, the feline lysosomal enzyme genes were located in linkage groups which were syntenic with their homologous positions in the human gene map. These assignments expand the genetic map of the cat and reaffirm the extensive syntenic homology between the chromosome maps of man and cat.
authors.affiliation: Biological Carcinogenesis Development Program, Frederick Cancer Research Facility, Maryland 21701.
authors.forename: D A
authors.initials: DA
authors.lastname: Gilbert
authors.forename: J S
authors.initials: JS
authors.lastname: O'Brien
authors.forename: S J
authors.initials: SJ
authors.lastname: O'Brien
mesh_terms: D000818:Animals; D002415:Cats / Q000235:genetics*; D002460:Cell Line; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D005796:Genes; D006026:Glycoside Hydrolases / Q000172:deficiency / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology*; D051379:Mice; D013045:Species Specificity
chemical_list: D006026:Glycoside Hydrolases