[Effect of detergent and glycerin on the efficacy of nasal immunotherapy with allergens and on the level of the lymphocyte subpopulation in the organs of local immunity].
Experimental mixed allergy to staphylococcal antigens in guinea pigs was treated by the intranasal administration of a staphylococcal allergen with a surfactant or glycerin added. The treatment was found to produce a hyposensitizing effect with respect to immediate and delayed hypersensitivity. The addition of glycerine enhanced this effect. At the same time the level of T-lymphocytes in the lungs and the lymph nodes of the respiratory tract returned to normal. Detergent used at a concentration of 2% abolished the hyposensitizing effect of the allergen, stimulated T-lymphocytes in the lymph nodes of the respiratory tract and the lungs; the number of T-suppressors decreased.
Sukhodoeva
G S
GS
Nugmanova
Zh S
ZhS
Bul'vakhter
Ia L
IaL
Shamsutdinova
G S
GS
Dobrina
V P
VP
D000281:Administration, Intranasal; D000485:Allergens / Q000008:administration & dosage*; D000818:Animals; D003888:Desensitization, Immunologic / Q000379:methods; D003902:Detergents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005990:Glycerol / Q000627:therapeutic use*; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology / Q000628:therapy; D006969:Hypersensitivity, Immediate / Q000276:immunology / Q000628:therapy; D007114:Immunization; D007167:Immunotherapy / Q000379:methods*; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D009930:Organic Chemicals; D013203:Staphylococcal Infections / Q000276:immunology / Q000628:therapy; D013211:Staphylococcus aureus / Q000276:immunology*; D013501:Surface-Active Agents / Q000627:therapeutic use*
D000485:Allergens; D003902:Detergents; D009930:Organic Chemicals; D013501:Surface-Active Agents; C058433:KS 3; D005990:Glycerol
Vliianie detergenta i glitserina na éffektivnost' nazal'noĭ immunoterapii allergenami i uroven' subpopuliatsii limfotsitov v organakh mestnogo immuniteta.