title: [Effect of aminophylline therapy in mature infants with sleep apnea syndrome].
abstract: Pneumograms of 33 fullterm infants (age 1-16 weeks) with idiopathic sleep apnea syndrome (SAS), treated with aminophyllin administered orally, were compared with pneumograms of 12 age-matched infants without aminophyllin treatment. In a one hour oxycardiorespirography (OCRG) all infants had pneumogram abnormalities defined as apneas greater than or equal to 15 s, greater than or equal to 3 apneas lasting 10 s, MA-value (mean duration of all apneas during sleep time) greater than or equal to 7 s/min, and greater than or equal to 3 episodes of periodic breathing. The diagnosis of an SAS, discussed as a possible risk factor of SIDS, was made in general in the presence of clinical symptoms such as apneas, cyanosis during sleep, poorly coordinated sucking, swallowing and respiration, and gastro-esophageal reflux (GER) in combination with an abnormal pneumogram. Of the 33 infants 12 with a history of an SIDS sibling were clinically asymptomatic. We found that after one week of aminophyllin treatment in 88% the pneumograms were normal. The mean plasma concentration of aminophyllin at this time was 8.3 micrograms/ml (range 4-19 micrograms/ml). All abnormalities showed a statistically significant reduction. In the infants without aminophyllin the pneumogram was still abnormal and no abnormality was significantly reduced. After at least 6 weeks we discontinued aminophyllin and one week later we monitored the OCRG. In 83% of the infants we found a normal pneumogram and compared to the initial pneumogram there was again a statistically significant difference.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Universitäts-Kinderklinik, Universität Graz.
authors.forename: F
authors.initials: F
authors.lastname: Reiterer
authors.forename: R
authors.initials: R
authors.lastname: Schenkeli
authors.forename: R
authors.initials: R
authors.lastname: Kurz
authors.forename: R
authors.initials: R
authors.lastname: Haidmayer
mesh_terms: D000628:Aminophylline / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012891:Sleep Apnea Syndromes / Q000188:drug therapy*; D013398:Sudden Infant Death / Q000517:prevention & control*
chemical_list: D000628:Aminophylline
vernacular_title: Effekt einer Aminophyllintherapie beim reifgeborenen Säugling mit Schlafapnoesyndrom.