Chemoprophylactic action of a substituted methyl benzimidazole carbamate against experimental nematode infections.
The prophylactic action of a substituted methylbenzimidazole carbamate was investigated against experimental nematode infections. The compound at the dose of 100 mg/kg x 1, i.m., protected hamsters against Ancylostoma ceylanicum for about 45 days and at 500 mg/kg x 1 protected rats against Nippostrongylus brasiliensis for 28 days. The uteri of female worms recovered from treated animals were devoid of ova so long the compound had considerable phophylactic action. In case of A. ceylanicum the compound exerted lethal action on L4 stage and in N. brasiliensis, mild action was noticed on L4 which became more pronounced on L5. The reference drugs, mebendazole and thiabendazole, had weaker prophylactic action.
Srivastava
J K
JK
Division of Parasitology, Central Drug Research Institute, Lucknow, India.
Gupta
S
S
Anuradha
Katiyar
J C
JC
D000722:Ancylostoma / Q000187:drug effects; D000724:Ancylostomiasis / Q000517:prevention & control*; D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D002219:Carbamates / Q000494:pharmacology / Q000627:therapeutic use*; D006224:Cricetinae; D005260:Female; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use; D009349:Nematode Infections / Q000517:prevention & control*; D009559:Nippostrongylus / Q000187:drug effects; D051381:Rats; D013827:Thiabendazole / Q000627:therapeutic use
D000969:Antinematodal Agents; D001562:Benzimidazoles; D002219:Carbamates; D008463:Mebendazole; C043589:CDRI 81-470; D013827:Thiabendazole