title: [Effect of adenosine on P50 and its relation to 2,3-diphosphoglycerate].
abstract: The effects of increasing doses of intravenous adenosine upon the dissociation haemoglobin curve (DHC) and its relation to the intraerythrocytic level of 2,3-diphosphoglyceric acid (2,3-DPG), were studied in 17 anesthetized dogs. The DHC moved significantly to the left in all dogs except at the dose of 120 micrograms/kg/min which induces a displacement to the right. These changes in the DHC were parallel to the intraerythrocytic levels of 2,3-DPG. We conclude that adenosine modifies the DHC, shifting it generally to the left, and that this effect seems to be related to a change in the intraerythrocytic level of 2,3-DPG.
authors.affiliation: Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.
authors.forename: P
authors.initials: P
authors.lastname: Silva Orrego
authors.forename: T
authors.initials: T
authors.lastname: Vicente Vera
authors.forename: F
authors.initials: F
authors.lastname: Amador
authors.forename: G
authors.initials: G
authors.lastname: Pastelín
mesh_terms: D019794:2,3-Diphosphoglycerate; D000241:Adenosine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004285:Dogs; D004909:Erythrocyte Indices / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D007275:Injections, Intravenous; D008297:Male
chemical_list: D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D019794:2,3-Diphosphoglycerate; D000241:Adenosine
vernacular_title: Efecto de la adenosina sobre la P50 y su relación con el 2,3-difosfoglicerato.