Cannabinol and cannabidiol in combination: temperature, open-field activity, and vocalization.
Rectal temperature as well as unconditioned activity in an open-field (O-F) arena, and palpation-induced vocalization were examined in rats treated intraperitoneally with cannabinol (CBN, 17.5 or 56 mg/kg) and cannabidiol (CBD, 10 or 30 mg/kg), either singly or in combination. CBN singly resulted in hypothermia which was not attenuated by the addition of CBD. CBN reduced ambulation and rearing activities as compared to vehicle-treated rats. CBD in combination with CBN did not attenuate these effects; the CBD doses in themselves appeared inactive. Vocalization occurred to a significantly greater extent in the CBN singly-treated rats as compared to the controls and the CBD singly-treated rats. Thus, CBD did not counteract the temperature and open-field effects induced by CBN. This is discussed in relation to previous results from drug discrimination experiments.
Hiltunen
A J
AJ
University of Uppsala, Department of Clinical Psychology, Sweden.
Järbe
T U
TU
Wängdahl
K
K
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002185:Cannabidiol / Q000494:pharmacology*; D002186:Cannabinoids / Q000494:pharmacology*; D002187:Cannabinol / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013239:Stereotyped Behavior / Q000187:drug effects; D014828:Vocalization, Animal / Q000187:drug effects*
D002186:Cannabinoids; D002185:Cannabidiol; D002187:Cannabinol