title: Conformational modification of the PRP-hexapeptide by a direct covalent attachment of aromatic side chain groups.
abstract: PRP-hexapeptide possessing the azo-bridge between Tyr1 and Phe5 residues, called azo-PRP-hexapeptide: (formula; see text), was synthesized and tested for immunoregulatory activity. High biological activity of the synthesized azo-PRP-hexapeptide suggests that the biologically active conformation of PRP-hexapeptide must be such that both aromatic rings (Tyr and Phe) are apparently close to each other.
authors.affiliation: Institute of Chemistry, University of Wroclaw, Poland.
authors.forename: Z
authors.initials: Z
authors.lastname: Szewczuk
authors.forename: A
authors.initials: A
authors.lastname: Kubik
authors.forename: I Z
authors.initials: IZ
authors.lastname: Siemion
authors.forename: Z
authors.initials: Z
authors.lastname: Wieczorek
authors.forename: K
authors.initials: K
authors.lastname: Spiegel
authors.forename: M
authors.initials: M
authors.lastname: Zimecki
authors.forename: M
authors.initials: M
authors.lastname: Janusz
authors.forename: J
authors.initials: J
authors.lastname: Lisowski
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis*; D000818:Animals; D000917:Antibody Formation; D007202:Indicators and Reagents; D051379:Mice; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000276:immunology; D009904:Optical Rotation
chemical_list: D000276:Adjuvants, Immunologic; D007202:Indicators and Reagents; D009842:Oligopeptides; C058579:proline-rich polypeptide, C-terminal hexapeptide