title: [Changes in the "latent" virulence of a vaccinal strain of Yersinia pestis multiplying within macrophages].
abstract: The multiplication of Y. pestis vaccinal strain inside peritoneal macrophages of guinea pigs and white mice in vitro leads to an essential increase in its latent virulence. This effect is most pronounced when guinea pig macrophages are used. Changes in the latent virulence of Y. pestis vaccinal strains, occurring in the process of their passage inside macrophages in vitro, correlate with those observed in vivo, i.e. in animal experiments.
authors.forename: G I
authors.initials: GI
authors.lastname: Vasil'eva
authors.forename: E P
authors.initials: EP
authors.lastname: Doroshenko
authors.forename: A K
authors.initials: AK
authors.lastname: Kiseleva
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000633:toxicity; D002455:Cell Division; D006168:Guinea Pigs; D008264:Macrophages / Q000382:microbiology*; D051381:Rats; D012692:Serial Passage; D014774:Virulence; D015010:Yersinia pestis / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology
chemical_list: D001428:Bacterial Vaccines
vernacular_title: Izmenenie "latentnoĭ" virulentnosti vaktsinnogo shtamma Yersinia pestis pri razmnozhenii vnutri makrofagov.