Dose-related neurochemical changes in the levels of gangliosides and glycogen in various regions of the rat brain and spinal cord following methyl parathion administration.
The aim of the present study was to evaluate the neurochemical changes in the levels of gangliosides and glycogen of the cerebral hemisphere, cerebellum, brain stem and spinal cord following the intraperitoneal (ip) injection of the organophosphate pesticide methyl parathion (1.0 mg, 1.5 mg and 2.0 mg/kg) to each rat of the experimental group daily for 7 days. A remarkable dose-related depletion in the concentration of gangliosides was discernible in all the regions of the CNS. Also, the contents of glycogen exhibited a decrement in different parts of the brain with all the 3 dose-schedules following methyl parathion toxicosis. The results suggest that the levels of gangliosides and glycogen are affected dose-dependently in various regions of the rat brain and spinal cord.
Khan
N A
NA
Interdisciplinary Brain Research Centre, Jawaharlal Nehru Medical College, Aligarh Muslim University, India.
Hasan
M
M
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005732:Gangliosides / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism*; D008297:Male; D008743:Methyl Parathion / Q000633:toxicity*; D010278:Parathion / Q000031:analogs & derivatives*; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects* / Q000378:metabolism
D005732:Gangliosides; D008743:Methyl Parathion; D010278:Parathion; D006003:Glycogen