The effect of amitriptyline on growth of olfactory and cerebral neurons in vitro.
The tricyclic antidepressant drug amitriptyline has a detrimental effect on neurite outgrowth in primary explant cultures containing either olfactory receptor neurons or cerebral neurons, from both rat and chick embryos. When the drug is added to the culture medium in doses similar to the plasma concentrations known to be therapeutic in humans, the number of explant cultures expressing neurites is significantly reduced. In higher doses, amitriptyline reduces the amount of olfactory marker protein synthesized by organ cultures of olfactory mucosa.
Farbman
A I
AI
Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208.
Gonzales
F
F
Chuah
M I
MI
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000166:cytology* / Q000187:drug effects / Q000196:embryology; D002642:Chick Embryo; D046508:Culture Techniques; D009474:Neurons / Q000187:drug effects*; D009830:Olfactory Bulb / Q000166:cytology* / Q000187:drug effects / Q000196:embryology; D051381:Rats
D000639:Amitriptyline