Effect of phospholipids on estrogen receptor of rat uterine cytosol.
Phospholipids such as phosphatidyl inositol and phosphatidyl serine inhibit the binding of R5020 and progestin receptors. The effect of phospholipids on the binding of estrogen and estrogen receptors of rat uterine cytosol was studied. Phosphatidyl choline, sphingomyelin, phosphatidyl inositol, phosphatidyl ethanolamine, cardiolipin, and phosphatidic acid inhibited the binding of estradiol and estrogen receptors. This inhibitory effect of phosphatidyl inositol and cardiolipin was dose dependent.
Mitsuhashi
N
N
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo.
Siotsu
H
H
Tsutsumi
O
O
Mizuno
M
M
D000818:Animals; D003600:Cytosol / Q000187:drug effects / Q000648:ultrastructure*; D005260:Female; D010743:Phospholipids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011960:Receptors, Estrogen / Q000187:drug effects* / Q000648:ultrastructure; D014599:Uterus / Q000187:drug effects / Q000648:ultrastructure*
D010743:Phospholipids; D011960:Receptors, Estrogen