title: Effects of apomorphine on punished and unpunished responding in the rat.
abstract: Apomorphine has been reported to increase shock-suppressed drinking, which suggests that it might have antianxiety activity. Because some drugs that increase shock-suppressed drinking are not active in other punishment procedures, the effects of apomorphine on punished and unpunished responding maintained by a multiple fixed-interval, fixed-interval schedule of food presentation were studied in rats. At doses from 3.125 to 100 micrograms/kg, apomorphine failed to increase punished or unpunished responding. In contrast, pentobarbital produced large increases in punished responding maintained by a fixed-interval schedule of food presentation.
authors.affiliation: Department of Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205.
authors.forename: D E
authors.initials: DE
authors.lastname: McMillan
authors.forename: R L
authors.initials: RL
authors.lastname: Evans
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D004597:Electroshock; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D011678:Punishment; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010424:Pentobarbital; D001058:Apomorphine