Developmental pattern of dopamine beta-hydroxylase induction in the adrenals of the rat. Influence of neonatal hypothyroidism.
The extent of dopamine beta-hydroxylase induction elicited by reserpine was measured in young rats rendered hypothyroid from birth and in controls. Hypothyroidism impairs adrenal dopamine beta-hydroxylase induction in the young rat up to 50 days of age and also in the adult. In contrast, hypothyroidism has practically no effect on brainstem dopamine beta-hydroxylase induction.
Chami
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N
Laboratoire d'Endocrinologie, Université Paris-Sud, Orsay, France.
Gripois
D
D
D000311:Adrenal Glands / Q000201:enzymology* / Q000254:growth & development; D000818:Animals; D001933:Brain Stem / Q000201:enzymology; D003409:Congenital Hypothyroidism; D004299:Dopamine beta-Hydroxylase / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D007037:Hypothyroidism / Q000201:enzymology*; D008297:Male; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*
D012110:Reserpine; D004299:Dopamine beta-Hydroxylase