title: The biosynthetic origins of rebeccamycin.
abstract: Experimental evidence is presented to demonstrate that the antitumor-antibiotic rebeccamycin is biosynthesized by Saccharothrix aerocolonigenes from one unit of glucose, one of methionine, and two of tryptophan. Evidence is presented that suggests that the alpha-amino group of neither tryptophan unit provides the nitrogen of the phthalimide system.
authors.affiliation: Bristol-Myers Pharmaceutical Research and Development Division, Wallingford, Connecticut 06492.
authors.forename: C J
authors.initials: CJ
authors.lastname: Pearce
authors.forename: T W
authors.initials: TW
authors.lastname: Doyle
authors.forename: S
authors.initials: S
authors.lastname: Forenza
authors.forename: K S
authors.initials: KS
authors.lastname: Lam
authors.forename: D R
authors.initials: DR
authors.lastname: Schroeder
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D002227:Carbazoles; D005947:Glucose / Q000378:metabolism; D007211:Indoles; D009682:Magnetic Resonance Spectroscopy; D008715:Methionine / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D002227:Carbazoles; D007211:Indoles; D014364:Tryptophan; C053339:rebeccamycin; D008715:Methionine; D005947:Glucose