[Coronary vessel tonus and cardiac resistance to ischemia in chronic adriamycin-induced myocardial damage].
The rats receiving a cumulative dose of adriamycin, 15-20 mg/kg exhibited delayed weight gain, ascites, and increased relative liver weight. The animals' isolated hearts perfused at a constant rate in the Krebs' solution in a retrograde fashion showed lowered perfusion pressure, indicating reduced coronary vascular tone. At the constant heart rate, the hearts from the adriamycin-treated animals consumed oxygen less at equally increased pressure. In total ischemia, higher cellular lactate and K+ yield occurred than in controls, the severity of acidosis being nearly similar. Prior to ischemia, the pressure produced by the hearts from adriamycin-treated animals was less but, following reperfusion, it more rapidly became normal than that in controls. The results suggest a compensatory increase in myocardial glycolysis during chronic administration of adriamycin.
Kapel'ko
V I
VI
Shul'zhenko
V S
VS
Khatkevich
A N
AN
D000818:Animals; D002908:Chronic Disease; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000517:prevention & control*; D003331:Coronary Vessels / Q000187:drug effects / Q000503:physiopathology*; D004317:Doxorubicin / Q000008:administration & dosage*; D004734:Energy Metabolism / Q000187:drug effects*; D006019:Glycolysis / Q000187:drug effects; D006333:Heart Failure / Q000139:chemically induced / Q000503:physiopathology*; D066298:In Vitro Techniques; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D004317:Doxorubicin
Tonus koronarnykh sosudov i rezistentnost' serdtsa k ishemii pri khronicheskom adriamitsinovom porazhenii miokarda.