title: Mapping of a human fibrillar collagen gene, pro alpha 1 (XI) (COL11A1), to the p21 region of chromosome 1.
abstract: Type XI collagen is a minor and poorly characterized structural component of cartilage. Recently, cDNA and genomic clones coding for the pro alpha 1 chain of human Type XI collagen, formerly 1 alpha collagen, have been isolated and fully characterized. Here we have used one such probe to establish the chromosomal localization of the pro alpha 1 (XI) collagen gene (COL11A1) by hybridization to filter-bound DNA isolated from flow-sorted chromosomes and by in situ hybridization on metaphase chromosomes. This combination of approaches has enabled us to locate COL1A11 in the p21 region of chromosome 1. This represents the first mapping of a Type XI collagen gene and the first assignment of a collagen locus to chromosome 1. These studies also provide additional evidence for the nearly uniform dispersion of the human fibrillar collagen genes in the human genome.
authors.affiliation: INSERM U73, Genetique et Pathologie Foetale, Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Henry
authors.forename: A
authors.initials: A
authors.lastname: Bernheim
authors.forename: M
authors.initials: M
authors.lastname: Bernard
authors.forename: M
authors.initials: M
authors.lastname: van der Rest
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: C
authors.initials: C
authors.lastname: Jeanpierre
authors.forename: F
authors.initials: F
authors.lastname: Barichard
authors.forename: R
authors.initials: R
authors.lastname: Berger
authors.forename: B R
authors.initials: BR
authors.lastname: Olsen
authors.forename: F
authors.initials: F
authors.lastname: Ramirez
mesh_terms: D002871:Chromosome Banding; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D003001:Cloning, Molecular; D003094:Collagen / Q000235:genetics*; D005796:Genes; D006801:Humans; D009693:Nucleic Acid Hybridization
chemical_list: D003094:Collagen