In vitro activity of cefixime, a new oral cephalosporin.
The in vitro activities of cefixime and seven comparative oral antimicrobials were studied. MIC90S of cefixime were 0.015-1 micrograms/ml for Haemophilus influenzae, Branhamella catarrhalis, Escherichia coli, Klebsiella, Citrobacter diversus, Proteus, Providencia, Aeromonas hydrophila and Streptococcus. MIC90S for other Enterobacteriaceae were greater than or equal to 2 micrograms/ml; 44% of those strains were inhibited by less than or equal 1 microgram/ml. Staphylococcus, Psuedomonas aeruginosa and Enterococcus faecalis were resistant to cefixime.
Fass
R J
RJ
Department of Internal Medicine, Ohio State University College of Medicine, Columbus 43210.
Helsel
V L
VL
D000284:Administration, Oral; D001419:Bacteria / Q000187:drug effects; D020682:Cefixime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
D020682:Cefixime; D002439:Cefotaxime