Influence of experimental diets on cholesterol and triglyceride levels of rabbit blood serum lipoproteins.
Groups of rabbits were fed for six weeks various diets: standard died + ethanol, high-cholesterol diet and a high-cholesterol + ethanol one. During the next six weeks every diet was supplemented with a fresh vegetable (carrot). Cholesterol and triglycerides were determined in the whole serum and in lipoprotein fractions. In rabbits fed standard diet ethanol caused a moderate elevation of VLDL cholesterol and triglyceride and LDL cholesterol levels. In animals on high-cholesterol diet cholesterol and triglyceride concentrations in these fractions were very high. Simultaneous consumption of large amounts of cholesterol and of ethanol resulted in a greater rise of cholesterol concentration in the whole serum and in VLDL and LDL fraction than did high-cholesterol diet alone. Addition of carrot caused a pronounced reduction of serum cholesterol concentration in animals fed all kinds of diets. The reduction concerned mainly VLDL.
Wehr
H
H
Department of Genetics, Institute of Psychiatry and Neurology, Warsaw.
Naruszewicz
M
M
Nowicka
G
G
Dziedziak
W
W
D000818:Animals; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D015243:Cholesterol, VLDL / Q000097:blood*; D004032:Diet; D000431:Ethanol / Q000494:pharmacology*; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D011817:Rabbits; D012016:Reference Values; D014280:Triglycerides / Q000097:blood*
D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D000431:Ethanol