[Early changes in the biosynthesis of proteins in the thymocytes of mice following exposure to lympholytic agents].
The method of two-dimensional electrophoresis was used to study protein biosynthesis in cytoplasm, nuclei and nuclear matrix of mouse thymocytes 15-75 min after exposure to ionizing radiation and hydrocortisone. Irradiation was shown to inhibit some cytoplasm proteins and to induce synthesis of a few polypeptides within the total nuclear proteins and nuclear matrix. Hydrocortisone promotes synthesis of some new proteins in all the fractions leading to the formation of new polypeptides. At least one common peptide is found within the total nuclear proteins and nuclear matrix after the effect of both factors.
Nazarova
L F
LF
Domashenko
A D
AD
Umanskiĭ
S R
SR
D000818:Animals; D002588:Cesium Radioisotopes; D005720:Gamma Rays; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D051379:Mice; D014176:Protein Biosynthesis; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D013997:Time Factors
D002588:Cesium Radioisotopes; D006854:Hydrocortisone
Rannye izmeneniia biosinteza belkov v timotsitakh mysheĭ posle vozdeĭstviia limfoliticheskikh agentov.