Primary structure of Klebsiella serotype K22 capsular polysaccharide: another glycan containing 4-O-[(S)-1-carboxyethyl]-D-glucuronic acid.
The primary structure of the acidic capsular polysaccharide isolated from Klebsiella serotype K22 has been investigated using methylation analysis, hydrolysis, bacteriophage-borne enzyme degradation, and n.m.r. spectroscopy. The repeating unit comprises the chain disaccharide----3)-beta-D-Galp-(1----4)-beta-D-Glcp-(1---- substituted by 4-O-[(S)-1-carboxyethyl]-beta-D-GlcpA-(1----6)-alpha-D-Glcp-(1---- at O-4 of the galactose. The galactose carries an O-acetyl group on position 6.
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School of Pharmaceutical Sciences, Rhodes University, Grahamstown, South Africa.
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Niemann
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D000942:Antigens, Bacterial / Q000032:analysis; D016667:Bacterial Capsules; D001435:Bacteriophages; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004187:Disaccharides; D005965:Glucuronates; D006868:Hydrolysis; D007709:Klebsiella / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D011135:Polysaccharides, Bacterial / Q000032:analysis; D012091:Repetitive Sequences, Nucleic Acid
D000942:Antigens, Bacterial; D004187:Disaccharides; D005965:Glucuronates; D011135:Polysaccharides, Bacterial; C058141:capsular polysaccharide K22; C058140:4-O-(1-carboxyethyl)glucuronic acid