title: [Acute retinal necrosis].
abstract: The authors report on three patients with acute retinal necrosis who were treated with the virostatic agent Acyclovir and who underwent vitreoretinal surgery with silicone oil filling for total retinal detachment. In two eyes the retina was reattached, but useful vision was only preserved in one patient. Titers from blood and the vitreous, as well as microscopic findings in retinal biopsies, support the view that the necrosis is caused by a herpes simplex virus infection. After therapy with Acyclovir was instituted no further progression on the necrosis was observed. However, the development of retinal detachment could not be prevented. Early diagnosis and antiviral therapy are essential to improve the otherwise poor prognosis in this rare syndrome.
authors.affiliation: Augenklinik der Medizinischen Universität zu Lübeck.
authors.forename: K
authors.initials: K
authors.lastname: Lucke
authors.forename: U
authors.initials: U
authors.lastname: Reinking
authors.forename: E
authors.initials: E
authors.lastname: el-Hifnawi
authors.forename: R H
authors.initials: RH
authors.lastname: Dennin
authors.forename: H
authors.initials: H
authors.lastname: Laqua
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009336:Necrosis; D011183:Postoperative Complications / Q000473:pathology; D012160:Retina / Q000473:pathology*; D014606:Uveitis, Anterior / Q000473:pathology; D014821:Vitrectomy
vernacular_title: Akute retinale Nekrose.