Mineralocorticoids are not involved in the antihypertensive effect of neonatal thymectomy in the genetically hypertensive LH rat.
1. In order to determine whether the antihypertensive effect of neonatal thymectomy in genetically hypertensive rats could be mediated through altered adrenal function, systolic blood pressure (SBP) and urinary excretion of deoxycorticosterone (DOC), corticosterone (B) and aldosterone were measured in thymectomized hypertensive (LH), normotensive (LN) and low-blood pressure (LL) rats of the Lyon strain. Sham-operated animals served as controls. 2. Neonatal thymectomy prevented the spontaneous increase of SBP in LH rats while it slightly decreased the SBP of LN and did not change that of LL rats. 3. Five week old sham-operated LH rats exhibited an increased urinary excretion of DOC and a decreased excretion of B compared with both LN and LL controls. Thymectomy did not alter the urinary excretion of adrenal steroids in LN and LL rats. The urinary excretion of B was markedly enhanced in thymectomized LH rats whereas that of DOC remained unmodified. 4. These data suggested that the thymus could be involved in the development of hypertension in LH rats. 5. The antihypertensive effect of thymectomy did not seem to be mediated by a decreased mineralocorticoid production in the genetically hypertensive rat of the Lyon strain.
Bataillard
A
A
Department of Physiology and Clinical Pharmacology, CNRS UA 606, Faculty of Pharmacy, Lyon, France.
Gomez-Sanchez
C E
CE
Vincent
M
M
Touraine
J L
JL
Sassard
J
J
D000450:Aldosterone / Q000652:urine; D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure; D003900:Desoxycorticosterone / Q000652:urine; D004195:Disease Models, Animal; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008901:Mineralocorticoids / Q000502:physiology*; D051381:Rats; D013934:Thymectomy; D013950:Thymus Gland / Q000502:physiology
D008901:Mineralocorticoids; D003900:Desoxycorticosterone; D000450:Aldosterone