Complete remission after ovariectomy for advanced breast cancer correlated with estrogen receptor status and urinary androgen excretion.
Our previous work showed urinary androgen excretion (A) as well as estrogen receptor (ER) to predict clinical response and survival after ovariectomy for advanced breast cancer. We here compare the complete responders with the partial responders to ovariectomy. The likelihood of CR (55% of responders) rather than PR was not strongly dependent on the location of metastases or on the ER/A status (though as noted previously there were no responses at all in the ER-/A- group), but CR did appear to increase survival.
Oriana
S
S
Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
Secreto
G
G
Di Fronzo
G
G
Böhm
S
S
Torri
A
A
D000728:Androgens / Q000652:urine*; D001943:Breast Neoplasms / Q000378:metabolism / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D010052:Ovariectomy; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis*; D012074:Remission Induction
D000728:Androgens; D011960:Receptors, Estrogen