title: Direct intraperitoneal insemination (DIPI) for the treatment of refractory infertility unrelated to female organic pelvic disease.
abstract: 344 couples with infertility unrelated to female organic pelvic disease underwent Direct Intraperitoneal Insemination (DIPI) for a total of a 429 DIPI cycles. Pregnancy per couple was 16.5% and per DIPI cycle 13.2%. DIPI was particularly effective in cases of infertility due to cervical mucus insufficiency and unexplained infertility with results respectively of 33.7% and 30.4% per couple and 30.7% and 28.7% per DIPI cycle. On the contrary, the results regarding male subfertility were 12.5% per couple and 10.5% per DIPI cycle. A significant difference was found (X2 A = 16.48, p less than 0.001) between these results and those of the group composed of cases of cervical mucus insufficiency and unexplained infertility. In cases of antisperm iso- and autoimmunization the results were on the whole poor, and were in any case influenced by corticosteroid pretreatment. The Pellet Swim-up Test (PST) proved to be a good prognostic sign for success of DIPI, since a significant difference was found between the PST group greater than or equal to 1.5 X 10(6)/ml (pregnancy per couple was 19.7% and per DIPI cycle 17.2%) and PST group less than 1.5 X 10(6)/ml (pregnancy per couple was 6.8% and per DIPI cycle was 4.5%) (X2 = 11.4. P less than 0.001).
authors.affiliation: Istituto Materno-Infantile dell'Università di Palermo.
authors.forename: C
authors.initials: C
authors.lastname: Cimino
authors.forename: G
authors.initials: G
authors.lastname: Guastella
authors.forename: G
authors.initials: G
authors.lastname: Comparetto
authors.forename: D
authors.initials: D
authors.lastname: Gullo
authors.forename: A
authors.initials: A
authors.lastname: Perino
authors.forename: M A
authors.initials: MA
authors.lastname: Benigno
authors.forename: G
authors.initials: G
authors.lastname: Barba
authors.forename: E
authors.initials: E
authors.lastname: Cittadini
mesh_terms: D001327:Autoimmune Diseases / Q000628:therapy*; D002582:Cervix Mucus; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000276:immunology / Q000628:therapy*; D007248:Infertility, Male / Q000276:immunology / Q000628:therapy*; D007315:Insemination, Artificial / Q000379:methods*; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D008297:Male; D010062:Ovulation Induction