Effects of aging on neuronal electrical membrane properties.
The electric membrane properties (EMP) of dorsal root ganglion (DRG) neurons in cell cultures prepared from control mice (8-14 weeks) and old mice (90-92 weeks) were compared. The old neurons had a number of significant alterations in EMP compared to controls including decreased electrical excitability, increased action potential duration and more pronounced biphasicity of the repolarization phase. The old neurons also had larger action potential overshoot and afterhyperpolarization. The pattern of altered electric membrane properties was consistent with an age-induced shift from voltage-sensitive sodium channels to less excitable voltage-sensitive calcium channels and also a decrease in potassium permeability during the repolarizing phase of the action potential.
Scott
B
B
Surrey Place Centre, Toronto, Ontario, Canada.
Leu
J
J
Cinader
B
B
D000375:Aging; D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D002478:Cells, Cultured; D004594:Electrophysiology; D005260:Female; D005727:Ganglia, Spinal / Q000166:cytology; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D013223:Statistics as Topic