A method for concurrent local intracranial drug infusion and electrophysiological recording.
A method employing a cannula-guidetube system with attached electrodes is described that permits infusions into discrete brain areas and simultaneous recording of multiunits or single units. This method can be used to determine the immediate local effects of drug infusion, and also to acquire electrophysiological feedback information in the process of placement and identification of cell populations at the injection site.
Marks
G A
GA
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235-9070.
Speciale
S G
SG
Roffwarg
H P
HP
D000818:Animals; D001921:Brain / Q000502:physiology*; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods*; D007263:Infusions, Parenteral / Q000295:instrumentation / Q000379:methods*; D009928:Organ Specificity