In vitro cytotoxic activity of aryl and heteroaryl-ONN-azoxycyanides.
Some aryl-N(O) = N-X and heteroaryl-N(O) = N-CN compounds were synthetized and tested against a culture of HeLa cells. The results obtained show that the - N(O) = N beta CN function, a new cytostatic group, is useful in the design of potential antitumoral compounds.
Fruttero
R
R
Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Italia.
Calvino
R
R
Di Stilo
A
A
Gasco
A
A
Galatulas
I
I
Bossa
R
R
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D003486:Cyanides / Q000138:chemical synthesis* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans
D000970:Antineoplastic Agents; D001391:Azo Compounds; D003486:Cyanides