title: [Persistence of nonspecific bronchial hyperreactivity in children with non-IgE dependent bronchial asthma: pharmacologic study with the Carbachol test].
abstract: The authors revise their preliminary experiment with the bronchial provocation test using carbachol in 50 children of 5 to 14 years with non-IgE dependent bronchial asthma who had been asymptomatic for one year prior to the test in order to make a clinical evaluation of asthma. The observe the evolution of the non-specific bronchial hyperreactivity (NSBH) with respect to the clinical remission and determine whether the persistence of NSBH is correlated to certain clinical, epidemiological and analytical parameters (peripheral eosinophilia, total IgE). In 22 children (44%) the functional respiratory examination was normal throughout each phase of the test. In the other 56%, the functional respiratory study using carbachol showed exhalation reductions which suggested NSBH. The most significant parameters were the reductions in FEV1, PEF (p less than 0.001) and FMEF (p = 0.001). Thus the patients revealing NSBH in the carbachol test are characterised for having revealed acute asthma of higher intensity, more often associated with an acute respiratory infection and with lower values of total IgE (p less than 0.05) with respect to the group without NSBH in the carbachol test.
authors.affiliation: Departamento de Pediatría, Facultad de Medicina, Universidad de Zaragoza.
authors.forename: M D
authors.initials: MD
authors.lastname: Vecora Navarro
authors.forename: G
authors.initials: G
authors.lastname: Oliván Gonzalvo
authors.forename: C
authors.initials: C
authors.lastname: Colás Sanz
authors.forename: J L
authors.initials: JL
authors.lastname: Escuer Alarma
authors.forename: F
authors.initials: F
authors.lastname: Duce Gracía
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology*; D001980:Bronchi / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D002217:Carbachol; D002648:Child; D002675:Child, Preschool; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D014797:Vital Capacity
chemical_list: D007073:Immunoglobulin E; D002217:Carbachol
vernacular_title: Persistencia de la hiperreactividad bronquial inespecífica en niños con asma bronquial no IgE dependientes: estudio farmacológico mediante test de carbacol.