title: [Aseptic necrosis of the head of long tubular bones in patients with lymphogranulomatosis].
abstract: The frequency of aseptic necrosis of femoral head was evaluated on the basis of 1066 case histories of Hodgkin's disease of all stages in patients aged 15 and more. The lesions were found in 14 patients (1.3%). Nine of them had received combined treatment for tumor, four--combination chemotherapy alone, and one--radiation alone. All had been given prednisolone. No significant correlation between treatment modality and osteonecrosis development was established. It is suggested that the effect of synergism of such damaging factors as ionizing irradiation, cytostatic drugs and glucocorticoids may be responsible for aseptic necrosis in cases of Hodgkin's disease.
authors.forename: S V
authors.initials: SV
authors.lastname: Kanaev
authors.forename: A V
authors.initials: AV
authors.lastname: Kholin
authors.forename: M L
authors.initials: ML
authors.lastname: Gershanovich
authors.forename: A P
authors.initials: AP
authors.lastname: Malinin
authors.forename: I I
authors.initials: II
authors.lastname: Semenov
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D003131:Combined Modality Therapy; D006689:Hodgkin Disease / Q000150:complications* / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D010020:Osteonecrosis / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D011878:Radiotherapy / Q000009:adverse effects; D012008:Recurrence
vernacular_title: Asepticheskiĭ nekroz golovok dlinnykh trubchatykh kosteĭ u bol'nykh limfogranulematozom.