A study of ionic conductances involved in plateau potential activity in putative vasopressinergic neurons in primary cell culture.
Vasopressin neurons in hypothalamic cell culture display regenerative calcium-dependent plateau potentials. The present study was undertaken to investigate the mechanisms underlying their time course and periodicity. Intracellular recordings showed that the duration of the plateaux was controlled by a progressive activation of a voltage- and calcium-dependent potassium conductance, but not by a progressive inactivation of calcium conductances. The refractory period appeared to be due to a calcium-dependent potassium conductance activated by membrane potential depolarization.
Legendre
P
P
I.N.S.E.R.M. U.176, Université de Bordeaux II, France.
Poulain
D A
DA
Vincent
J D
JD
D000818:Animals; D002478:Cells, Cultured; D005333:Fetus / Q000166:cytology; D007031:Hypothalamus / Q000166:cytology / Q000502:physiology*; D008564:Membrane Potentials; D051379:Mice; D009431:Neural Conduction; D009474:Neurons / Q000502:physiology*; D011188:Potassium / Q000502:physiology*; D014667:Vasopressins / Q000502:physiology*
D014667:Vasopressins; D011188:Potassium