title: Soman enhances nicotinic depolarizations, and depresses muscarinic hyperpolarizations in parasympathetic neurons.
abstract: Intracellular recording techniques were used to study the action of an irreversible anticholinesterase, soman, on cholinergic transmission in cat bladder parasympathetic neurons. With soman (0.1-10 microM) treatment, nicotinic depolarizations were increased in amplitude and prolonged in duration, whereas muscarinic hyperpolarizations showed either a depressed amplitude and prolonged duration, or were completely blocked. These data suggest that the final result of soman action is different at nicotinic and muscarinic receptor-channel complexes in parasympathetic neurons.
authors.affiliation: Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston 77550.
authors.forename: E
authors.initials: E
authors.lastname: Kumamoto
authors.forename: P
authors.initials: P
authors.lastname: Shinnick-Gallagher
mesh_terms: D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002415:Cats; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005726:Ganglia, Parasympathetic / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008464:Mecamylamine / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010646:Phentolamine / Q000494:pharmacology; D011976:Receptors, Muscarinic / Q000502:physiology*; D011978:Receptors, Nicotinic / Q000502:physiology*; D012016:Reference Values; D012999:Soman / Q000494:pharmacology*; D001743:Urinary Bladder / Q000294:innervation*
chemical_list: D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D002110:Caffeine; D008464:Mecamylamine; D012999:Soman; D010646:Phentolamine