title: Autoradiographic investigation of effects of high-dose colchicine on dentinogenesis in rat incisors.
abstract: Twelve female Wistar rats received 1.5 mg/kg of colchicine (CLC) intravenously. Control animals were similarly injected with isotonic saline solution. The animals were killed 5 h, 24 h, 3 days and 7 days after injection. Ninety minutes prior to sacrifice, all animals received an intraperitoneal injection of 3H-proline. Autoradiograms of maxillary incisors showed that CLC increased the retention of the labeled precursor in the odontoblasts. It was also shown that the odontoblasts in the different sectors of the rat incisor present different sensitivities to the CLC action.
authors.affiliation: Department of Pathology, Dental Faculty of São José dos Campos, UNESP, São Paulo, Brazil.
authors.forename: T O
authors.initials: TO
authors.lastname: Nogueira
authors.forename: T M
authors.initials: TM
authors.lastname: Zorn
authors.forename: T
authors.initials: T
authors.lastname: Stene
authors.forename: H S
authors.initials: HS
authors.lastname: Koppang
mesh_terms: D000818:Animals; D001345:Autoradiography; D003078:Colchicine / Q000494:pharmacology*; D003804:Dentin / Q000378:metabolism; D003810:Dentinogenesis / Q000187:drug effects*; D005260:Female; D007180:Incisor / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D011392:Proline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011392:Proline; D003078:Colchicine