Effects of short term experimental diabetes on brain serotonin metabolism.
Serotonin metabolism was studied in several brain regions of control and Streptozotocin-treated male Wistar rats. After induction of diabetes, the animals were killed at 24 hours. Concentrations of brain tryptophan show a generalized increase in all brain regions, being only significant in medulla-pons. Serotonin levels do not change, while 5-HIAA concentrations, as well as the ratio 5-HIAA/5-HT, show significant increases in medulla-pons and mid-brain.
Atienza
G
G
Departamento de Fisiología, Facultad de Biología, Santiago de Compostela, Spain.
Aldegunde
M
M
Durán
R
R
Veira
J A
JA
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors; D014364:Tryptophan / Q000378:metabolism
D012701:Serotonin; D014364:Tryptophan