Distribution of total estradiol receptor levels in various segments and tissues of the normal and pathological human uterus.
Estradiol receptor (RE2) levels were measured in normal (n = 22) and pathological (n = 14) human endometria and in various segments and tissues of the same uteri (n = 8). The highest total estradiol levels (TRE2) were found in midcycle normal cyclic endometria and the lowest in the secretory phase of normal cyclic endometria and in normal postmenopausal endometria (the TRE2 levels in the latter two groups were within similar ranges). The highest nuclear RE2 levels were found in proliferative-phase normal cyclic endometria. TRE2 levels in pathological postmenopausal endometria were high, in the range of those found in proliferative normal cyclic endometria, but the nuclear RE2 levels were low as compared with those in normal proliferative endometria. Examination of the distribution of the TRE2 levels in various segments and tissues of normal proliferative uteri revealed similar trends in all cases as follows: the highest levels were measured in the functional endometrium (fundus) and the lowest in the myometrium (fundus). Basal endometrial TRE2 levels decreased along the longitudinal axis from fundus to isthmus. In 4 cases, TRE2 levels in leiomyoma tissues were higher than those in the corresponding myometrium. These results indicate the possibility of a differing regulating mechanism of the RE2 in various segments or tissues of the human uterus.
Gorodeski
I G
IG
Department of Obstetrics and Gynecology 'B', Meir General Hospital, Sapir Medical Center, Kfar Saba, Israel.
Bahary
C M
CM
Lunenfeld
B
B
Beery
R
R
Geier
A
A
D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D011959:Receptors, Estradiol / Q000032:analysis*; D014591:Uterine Diseases / Q000473:pathology; D014599:Uterus / Q000032:analysis*
D011959:Receptors, Estradiol