The hemopexin gene maps to the same location as the beta-globin gene cluster on human chromosome 11.
Using human hemopexin cDNA clones isolated from lambda gt11 cDNA library as probes, we have carried out Southern blot analysis of a series of human-Chinese hamster somatic cell hybrids containing different combinations of human chromosomes. Synteny analysis revealed 100% concordance between the hemopexin gene and human chromosome 11. In situ hybridization of 3H-labeled hemopexin cDNA to metaphase chromosomes prepared from human lymphocytes further localized the gene to the region p15.4-p15.5, the same location as the beta-globin gene cluster.
Law
M L
ML
Eleanor Roosevelt Institute for Cancer Research, Denver, Colorado 80206.
Cai
G Y
GY
Hartz
J A
JA
Jones
C
C
Kao
F T
FT
D000818:Animals; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000235:genetics; D005796:Genes; D005914:Globins / Q000235:genetics*; D006466:Hemopexin / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells / Q000166:cytology; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization
D005914:Globins; D004247:DNA; D006466:Hemopexin