Serum neutrophil chemotactic activity (NCA) during aspirin-induced urticaria and angioedema.
In order to establish the role of mast cells in aspirin-induced urticaria and angioedema, neutrophil chemotactic activity (NCA) in serum was assayed using the method of Nelson before and after aspirin challenge. In 14 (82.4%) persons sensitive to aspirin an increase in NCA during aspirin-induced urticaria and angioedema was observed and in 9 of them (52.9%) it was considerable (index NCA greater than or equal to 2.0). None of the 18 persons from the control group with idiopathic urticaria and/or angioedema but without aspirin-sensitivity exhibit an increase in NCA after aspirin challenge. The author assumes that mast cell degranulation does occur in aspirin-induced urticaria and angioedema.
Grzelewska-Rzymowska
I
I
Department of Pneumonology and Allergology, Medical Academy of Lodz, Poland.
D000293:Adolescent; D000328:Adult; D000799:Angioedema / Q000139:chemically induced* / Q000276:immunology; D001241:Aspirin / Q000009:adverse effects* / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000276:immunology; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D014581:Urticaria / Q000139:chemically induced* / Q000276:immunology
D001241:Aspirin