Angiotensin II binding sites in the superior cervical ganglia of spontaneously hypertensive and Wistar-Kyoto rats after preganglionic denervation.
Angiotensin II binding was higher in superior cervical ganglia of adult spontaneously hypertensive rats (SHR) when compared to ganglia of Wistar-Kyoto (WKY) rats (571 +/- 29 and 375 +/- 9 fmol/mg protein, SHR and WKY, respectively, P less than 0.05). Unilateral preganglionic denervation reduced binding site density in ganglia of WKY (-39%, P less than 0.05 vs sham operated ganglia in WKY), and the decrease of binding sites was larger in SHR (-59%, P less than 0.01, operated vs sham operated ganglia in SHR). Part of the binding sites in the superior cervical ganglia may be present in or be associated to preganglionic nerves, and the number of these sites is higher in SHR.
Pinto
J E
JE
Unit on Preclinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892.
Nazarali
A J
AJ
Saavedra
J M
JM
D000818:Animals; D001339:Autonomic Fibers, Preganglionic / Q000502:physiology*; D005728:Ganglia, Sympathetic / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism*; D011919:Rats, Inbred Strains / Q000378:metabolism*; D011945:Receptors, Angiotensin / Q000378:metabolism*
D011945:Receptors, Angiotensin