title: Plasmapheresis in the treatment of acute relapsing inflammatory demyelinating polyradiculoneuropathy associated with human immunodeficiency virus infection: a case report.
abstract: Neurologic complications, including both the acute and chronic forms of inflammatory demyelinating polyradiculoneuropathy (IDP) are becoming more prevalent among patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related-complex (ARC). Although the etiology of the above radiculoneuropathies is not known, an autoimmune process has been postulated. Plasmapheresis has been reported to be of benefit in both the acute and chronic forms of these neuropathies. In this report we describe the use of plasmapheresis in the treatment of a patient with ARC and the acute relapsing form of IDP. The treatment consisted of an intensive course of plasmapheresis following his initial presentation and after an acute relapse which occurred several weeks after his initial presentation. Both the initial presentation and relapse involved respiratory compromise necessitating intubation and mechanical ventilation. In both instances marked clinical improvement was achieved after initiation of plasmapheresis. Thus, plasmapheresis may have a role in the management of acute relapsing IDP associated with human immunodeficiency virus infection.
authors.affiliation: Taft B. Schreiber Blood Bank, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
authors.forename: D
authors.initials: D
authors.lastname: Wuest
authors.forename: D
authors.initials: D
authors.lastname: Goldfinger
mesh_terms: D000386:AIDS-Related Complex / Q000150:complications*; D000208:Acute Disease; D000328:Adult; D003711:Demyelinating Diseases / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D010956:Plasmapheresis; D011129:Polyradiculoneuropathy / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D012008:Recurrence