title: Intraventricular injection of antiserum to nerve growth factor delays the development of amygdaloid kindling.
abstract: To investigate the possibility that nerve growth factor (NGF) may play some role in the development of kindling, rabbit anti-NGF serum was injected into the third ventricle on the first 3 days of daily electrical stimulation of the basolateral amygdala. The number of stimulations required to reach full amygdaloid kindling increased significantly in the rat injected with anti-NGF serum compared to that in the rat injected with normal rabbit serum. It was confirmed that anti-NGF serum did not act as an anticonvulsant. The results demonstrate that NGF may be important for the long-lasting neuronal changes induced by daily electrical stimulation of the amygdala.
authors.affiliation: Department of Physiology, Yokohama City University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Funabashi
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: F
authors.initials: F
authors.lastname: Kimura
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D002552:Cerebral Ventricles / Q000502:physiology*; D004558:Electric Stimulation; D005260:Female; D007106:Immune Sera / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007696:Kindling, Neurologic; D009414:Nerve Growth Factors / Q000276:immunology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
chemical_list: D007106:Immune Sera; D009414:Nerve Growth Factors