Three years experience with denaturated venous homografts as an arterial substitute: a clinical, pathological and immunological study.
Over a three-year-period 105 peripheral arterial reconstructions were performed using a denaturated venous homograft in a group of patients with no suitable autologous vein. A retrospective analysis has been carried out to investigate the patency rate of this graft. After three years 64% of all grafts are functioning well (according to the Life Table Method, Kaplan & Meyer). No significant differences in patency rates were found between reversed autologous veins and the material tested in this study but analysis of grafts removed after failure showed obstruction due to thrombosis or aneurysmal dilatation. No evidence of an immune response to the grafts was seen.
van Reedt Dortland
R W
RW
Department of Vascular Surgery, University Hospital Utrecht, The Netherlands.
Schuurman
H J
HJ
Slootweg
P J
PJ
Steijling
J J
JJ
Dimitroff
A
A
Theodorides
T
T
D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012501:Saphenous Vein / Q000276:immunology / Q000473:pathology / Q000502:physiology / Q000637:transplantation*; D014184:Transplantation, Homologous; D014654:Vascular Patency