No diabetogenic effect of N-nitrosomethylurea on pregnant BALB/c mice and their progeny.
Our studies give evidence that N-nitrosomethylurea applied to BALB/c mice one day before or after mating or during pregnancy (12th day) even in small (16 or 32 mg/kg) and repeated doses (16 mg/kg on 5 consecutive days, total dose 80 mg/kg) is a more toxic than potent diabetogenic agent. Mortality rises in parent mice and their progeny with no influence on glucose tolerance test and blood glucose level over the whole investigation period (4 hours-12 weeks).
Voss
C
C
Institute of Biochemistry, Ernst-Moritz-Arndt-University Medical School, Greifswald/GDR.
Zühlke
H
H
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008770:Methylnitrosourea / Q000009:adverse effects / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*
D001786:Blood Glucose; D008770:Methylnitrosourea