title: Thromboembolism and problems of anti-coagulation after prosthetic valve replacement.
abstract: 104 patients who had prosthetic valve replacements were followed up for a period from 5 months to 63 months. The incidence of minor and major thromboembolism for aortic valve replacement was 1.2%/Pt.yr respectively, while the incidence for mitral valve replacement was 3.8%/Pt.yr. respectively. The haemorrhagic complication rate due to anticoagulation was 3.7%/Pt.yr. and the fatality rate due to it was 1.4%/Pt.yr. 75% of the patients who had haemorrhagic complications had a thrombotest of less than 4%. Anticoagulation related morbidity and mortality are significant in this series. Elimination of anticoagulation related complications could have improved the long term mortality rate from 2.95%/Pt.yr. to 1.4%/Pt.yr.
authors.affiliation: Department of Cardiothoracic Surgery, Singapore General Hospital.
authors.forename: C
authors.initials: C
authors.lastname: Sivathasan
authors.forename: F K
authors.initials: FK
authors.lastname: Chia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011474:Prosthesis Design; D013923:Thromboembolism / Q000517:prevention & control*; D014859:Warfarin / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D014859:Warfarin