L-657,398, a novel antifungal agent: fermentation, isolation, structural elucidation and biological properties.
L-657,398 is a broad spectrum antifungal agent isolated from solid fermentation or from the mycelium of the liquid fermentation of Aspergillus ochraceus. Structurally, the compound is a novel pyrollidine related to anisomycin.
Schwartz
R E
RE
Merck Sharp & Dohme Research Laboratories, Rahway, N.J.
Liesch
J
J
Hensens
O
O
Zitano
L
L
Honeycutt
S
S
Garrity
G
G
Fromtling
R A
RA
Onishi
J
J
Monaghan
R
R
D000841:Anisomycin / Q000031:analogs & derivatives / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D011759:Pyrrolidines / Q000302:isolation & purification*
D000935:Antifungal Agents; D011759:Pyrrolidines; C058280:preussin; D000841:Anisomycin