title: Abnormality of gangliosides in erythrocyte membranes of schizophrenic patients.
abstract: The pattern of gangliosides in membranes of erythrocytes was examined in healthy donors, in acute schizophrenics without neuroleptic treatment and in alcohol-dependent patients. 7 different gangliosides could be detected. Healthy donors were characterized by the following ganglioside pattern: GX = 5.8%; GT1b = 6.7%; FucGD1b = 5.2%; GD1a = 12.6%, GD3 = 9.2%, SPG = 43.5%, and GM3 = 17.0%. In schizophrenic patients the GM3 and GD3 fractions were increased. No difference was found between the control group and the alcoholics.
authors.affiliation: Institute of Pathological Biochemistry, Academy of Medicine Magdeburg, GDR.
authors.forename: U
authors.initials: U
authors.lastname: Haselhorst
authors.forename: H
authors.initials: H
authors.lastname: Schenk
authors.forename: I
authors.initials: I
authors.lastname: Beyer
authors.forename: R
authors.initials: R
authors.lastname: Uebelhack
authors.forename: E
authors.initials: E
authors.lastname: Franke
authors.forename: V
authors.initials: V
authors.lastname: Kielstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000097:blood; D004910:Erythrocyte Membrane / Q000032:analysis*; D005260:Female; D005679:G(M3) Ganglioside / Q000097:blood; D005732:Gangliosides / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood*
chemical_list: D005679:G(M3) Ganglioside; D005732:Gangliosides