Panniculitis following steroid therapy.
A 10-year-old child experienced painful nodular lesions following rapid withdrawal of large doses of orally-administered prednisolone prescribed for treatment of an episode of hepatic encephalopathy. Histopathologic examination of a nodule revealed extensive fat necrosis, needle-shaped clefts within fat cells, and marked nonspecific granulomatous infiltrate that spared the interlobular septa. The lesions subsided completely in about four weeks without any treatment, leaving only residual hyperpigmentation.
Saxena
A K
AK
Department of Dermatology and Leprosy, Safdarjang Hospital, New Delhi, India.
Nigam
P K
PK
D002648:Child; D005260:Female; D006501:Hepatic Encephalopathy / Q000188:drug therapy; D006801:Humans; D015434:Panniculitis / Q000139:chemically induced* / Q000473:pathology; D011239:Prednisolone / Q000009:adverse effects* / Q000627:therapeutic use
D011239:Prednisolone