title: Inhibition of ConA-induced proliferative response in human lymphocytes by podophyllotoxin and a detergent, Tween80.
abstract: Podophyllotoxin (CPH86), at concentrations of 5 ng/ml or more, inhibited [3H]-thymidine uptake of ConA-induced proliferation of human peripheral mononuclear blood cells. Tween80, the detergent included in the anti-inflammatory drug Proresid, containing podophyllum lignan derivatives, also inhibited lymphocyte proliferation in a dose-dependent manner. Combination of the two drugs did not, or did only weakly, potentiate the inhibitory effect of each drug.
authors.affiliation: Department of Rheumatology, University Hospital, Lund, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Månsson
authors.forename: P
authors.initials: P
authors.lastname: Geborek
authors.forename: T
authors.initials: T
authors.lastname: Hallberg
authors.forename: G
authors.initials: G
authors.lastname: Sturfelt
mesh_terms: D003208:Concanavalin A / Q000037:antagonists & inhibitors*; D004357:Drug Synergism; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D011034:Podophyllotoxin / Q000494:pharmacology*; D011136:Polysorbates / Q000494:pharmacology
chemical_list: D011136:Polysorbates; D003208:Concanavalin A; D011034:Podophyllotoxin