Structural analysis of 21-hydroxypregn-4-ene-3,20-dione (deoxycorticosterone) derivative compounds. Part I: Synthesis and circular dichroism identification.
Deoxycorticosterone (DOC) derivative compounds (DOC, DOC 21-acetate, and 7-mercaptopropionic DOC) have been prepared and purified by high pressure liquid chromatography. Synthesis products have been identified, and three chromophores have been displayed by their n----II and II----II dichroic transitions. A normal half-chair conformation is favored in ring A.
Kouadio
L
L
Laboratoire de Chimie Analytique II, Hopital de l'Antiquaille, Universite Claude Bernard Lyon, France.
Bernard
P
P
Sabot
J F
JF
Petit-Ramel
M M
MM
Barbier
C M
CM
Pinatel
H J
HJ
D002942:Circular Dichroism; D003900:Desoxycorticosterone / Q000031:analogs & derivatives* / Q000032:analysis* / Q000138:chemical synthesis; D006868:Hydrolysis; D008968:Molecular Conformation
C058405:desoxycorticosterone-7-mercaptopropionic acid; D003900:Desoxycorticosterone