Influence of food on steady state serum concentrations of theophylline from two controlled-release preparations.
The influence of food on the bioavailability of the controlled-release theophylline preparations Theostat and Theolair was studied in 12 healthy subjects after multiple dosing (b.i.d. for 6 days). On the morning of days 5 and 6, the volunteers took these products once after overnight fasting and once after a high-fat breakfast. For Theostat, serum theophylline levels and pharmacokinetic parameters were not affected by the intake of breakfast. For Theolair, serum theophylline concentrations were markedly lower after breakfast, with a significant decrease of Cmax and AUC. This study confirms the necessity of studying the influence of food on the bioavailability of theophylline controlled-release preparations.
Lefebvre
R A
RA
Heymans Institute of Pharmacology, University of Gent Medical School, Belgium.
Belpaire
F M
FM
Bogaert
M G
MG
D000328:Adult; D003692:Delayed-Action Preparations; D005260:Female; D005502:Food; D006801:Humans; D008297:Male; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics
D003692:Delayed-Action Preparations; D013806:Theophylline