title: The acute response of indium-111 labelled platelets to arteriotomy closure.
abstract: A standard 40 mm arteriotomy was created in canine iliac and carotid arteries and then closed by either direct suture without a patch, with a vein patch or with a polytetrafluoroethylene patch (PTFE). The uptake of 111-Indium oxine labelled platelets at 2 hours after operation was compared between the groups. Arteriotomies closed with a PTFE patch demonstrated significantly greater platelet aggregation than those closed with a vein patch. Primary closure without a patch was associated with the least platelet uptake of all (PTFE versus vein patch, P less than 0.01; PTFE versus no patch, P less than 0.01; vein patch versus no patch, P less than 0.05). Light and electron microscopy confirmed the radioisotopic findings.
authors.affiliation: Surgical Professorial Unit, St. Vincent's Hospital, University of New South Wales, Sydney, Australia.
authors.forename: P A
authors.initials: PA
authors.lastname: Nash
authors.forename: R S
authors.initials: RS
authors.lastname: Lord
authors.forename: H Q
authors.initials: HQ
authors.lastname: Zhang
authors.forename: P
authors.initials: P
authors.lastname: Yeates
authors.forename: M J
authors.initials: MJ
authors.lastname: Whitfeld
authors.forename: J
authors.initials: J
authors.lastname: Freund
authors.forename: N A
authors.initials: NA
authors.lastname: Pocock
authors.forename: M
authors.initials: M
authors.lastname: Yeates
authors.forename: K H
authors.initials: KH
authors.lastname: Goh
mesh_terms: D000818:Animals; D001158:Arteries / Q000601:surgery* / Q000648:ultrastructure; D001792:Blood Platelets / Q000502:physiology* / Q000648:ultrastructure; D004285:Dogs; D007083:Iliac Artery / Q000601:surgery; D007084:Iliac Vein / Q000637:transplantation; D007205:Indium Radioisotopes; D008855:Microscopy, Electron, Scanning; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D011138:Polytetrafluoroethylene; D019736:Prostheses and Implants
chemical_list: D007205:Indium Radioisotopes; D011138:Polytetrafluoroethylene