title: Hepatic drug disposition in multiple organ failure.
abstract: In 15 patients with multiple organ failure of septic etiology, some principal partial hepatic functions of drug disposition were measured by the test substances galactose, indocyanine green, theophylline and 4-methylumbelliferon. Glucuronidation was not impaired in any case, whereas flow-limited and capacity-limited drug elimination can be influenced. Drug monitoring and intense clinical observation seem necessary to improve drug therapy and the outcome of patients with multiple organ failure.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Knappschaftskrankenhaus, Ruhr-Uni-Bochum, W. Germany.
authors.forename: W
authors.initials: W
authors.lastname: Schregel
authors.forename: H D
authors.initials: HD
authors.lastname: Kuntz
authors.forename: M
authors.initials: M
authors.lastname: Vitt
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005690:Galactose; D006801:Humans; D006923:Hymecromone; D007208:Indocyanine Green; D008099:Liver / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000378:metabolism* / Q000503:physiopathology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D013806:Theophylline
chemical_list: D004364:Pharmaceutical Preparations; D006923:Hymecromone; D013806:Theophylline; D007208:Indocyanine Green; D005690:Galactose