title: High molecular weight microtubule-associated proteins bind to actin lattices (Hirano bodies).
abstract: Hirano bodies are filamentous, paracrystalline inclusions that are found in dendrites and cell bodies of neurons in Alzheimer's and other neurodegenerative diseases. Actin appears to be a major component of these structures. We present evidence that tropomyosin and high molecular weight microtubule-associated proteins (MAPs) are also components of Hirano bodies. Although an association between actin and MAPs has been noted in vitro, interactions in vivo have not heretofore been demonstrated. Since microtubules are not present in Hirano bodies, and anti-tubulin and anti-neurofilament antibodies do not bind to Hirano bodies, the association between MAPs and these inclusions is likely a result of interactions between MAPs and actin, and not MAPs and microtubules or neurofilaments.
authors.affiliation: Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx, NY 10461.
authors.forename: C
authors.initials: C
authors.lastname: Peterson
authors.forename: Y
authors.initials: Y
authors.lastname: Kress
authors.forename: R
authors.initials: R
authors.lastname: Vallee
authors.forename: J E
authors.initials: JE
authors.lastname: Goldman
mesh_terms: D000199:Actins / Q000378:metabolism*; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000911:Antibodies, Monoclonal; D003594:Cytoplasmic Granules / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008970:Molecular Weight
chemical_list: D000199:Actins; D000911:Antibodies, Monoclonal; D008869:Microtubule-Associated Proteins