title: Hepatic failure in dairy cattle following mastitis or metritis.
abstract: Hepatic failure developed following mastitis or metritis in five adult cows. In all five cases, cows initially showed clinical signs compatible with endotoxemia, which resolved with appropriate therapy for the mastitis or metritis. Subsequently, signs of liver failure developed including profound anorexia, weight loss, cessation of milk production, and in one case, photosensitization. Four cows had laboratory evidence of liver disease and failure (abnormally prolonged sulfobromophthalein [BSP] clearance half-life and abnormally high serum liver enzyme activity). Hepatocellular necrosis or vacuolization was seen on histopathologic examination of liver specimens from all five cows. The hepatocellular necrosis, in some cases, was thought to be due to the direct or indirect effects of endotoxin on the liver. Three of the cows responded to symptomatic therapy. One cow failed to respond and one was not treated.
authors.affiliation: Department of Clinical Studies, New Bolton Center, University of Pennsylvania, School of Veterinary Medicine, Kennett Square 19348.
authors.forename: R W
authors.initials: RW
authors.lastname: Sweeney
authors.forename: T J
authors.initials: TJ
authors.lastname: Divers
authors.forename: R H
authors.initials: RH
authors.lastname: Whitlock
authors.forename: H M
authors.initials: HM
authors.lastname: Acland
authors.forename: E P
authors.initials: EP
authors.lastname: Tulleners
authors.forename: J E
authors.initials: JE
authors.lastname: Palmer
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy; D004716:Endometritis / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D008413:Mastitis / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D010118:Oxytetracycline / Q000627:therapeutic use; D010406:Penicillins / Q000627:therapeutic use
chemical_list: D005839:Gentamicins; D010406:Penicillins; D010118:Oxytetracycline