Lipopolysaccharide-dependent enhancement of adherence-mediated chemiluminescence response of polymorphonuclear leukocytes.
Adherence of resting polymorphonuclear leukocytes to nylon fibre increased the chemiluminescence response (CL) from 99,400 to 910,300 cpm/25,000 PMNL. This effect could be amplified by lipopolysaccharide (LPS) priming of granulocytes in a dose-dependent fashion. The results of nylon fibre adherence experiments suggest an in vitro model that might approximate certain conditions of in vivo PMNL-endothelial adherence and respiratory burst activation, and these reactions of polymorphonuclear leukocytes may contribute to the pathomechanisms of the Adult Respiratory Distress Syndrome.
Dwenger
A
A
Abteilung für Klinische Biochemie, Medizinische Hochschule Hannover, FRG.
Schweitzer
G
G
Funck
M
M
D002448:Cell Adhesion / Q000187:drug effects; D006098:Granulocytes / Q000166:cytology / Q000502:physiology; D006801:Humans; D007700:Kinetics; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008163:Luminescent Measurements; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D009757:Nylons
D008070:Lipopolysaccharides; D009757:Nylons