title: Antibiotics from basidiomycetes. XXIX: Pilatin, a new antibiotically active marasmane derivative from cultures of Flagelloscypha pilatii agerer.
abstract: Pilatin, a new marasmane derivative, was isolated from fermentations of the cyphelloid fungus Flagelloscypha pilatii. Its structure was determined by chemical and physical methods. Pilatin inhibits the growth of bacteria and fungi at concentrations of 5-50 micrograms/ml. The compound is highly cytotoxic. The incorporation of thymidine and uridine into DNA and RNA in Ehrlich carcinoma ascitic cells is strongly inhibited by pilatin. Like marasmic acid pilatin causes frameshift mutations in Salmonella typhimurium TA98.
authors.affiliation: LB Biotechnologie der Universität, Kaiserslautern, FRG.
authors.forename: J
authors.initials: J
authors.lastname: Heim
authors.forename: T
authors.initials: T
authors.lastname: Anke
authors.forename: U
authors.initials: U
authors.lastname: Mocek
authors.forename: B
authors.initials: B
authors.lastname: Steffan
authors.forename: W
authors.initials: W
authors.lastname: Steglich
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000378:metabolism*; D001952:Bridged-Ring Compounds / Q000302:isolation & purification / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D008968:Molecular Conformation; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; D001952:Bridged-Ring Compounds; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C058275:pilatin; C037486:marasmic acid