title: Growth characteristics of cultured human normal bladder epithelial cells: a comparison with urothelial carcinoma cell cultures.
abstract: We present the in vitro growth characteristics and morphology of the first established long-term culture of human normal bladder epithelium. Normal bladder cells were grown with a mean generation time of 44 h and a life span of 33 population doublings in 12 weeks. The cells exhibited contact inhibition of growth. The cultures were morphologically examined and compared with transitional cell carcinoma in culture.
authors.affiliation: Department of Experimental Physiology, University of Athens Medical School, Greece.
authors.forename: H
authors.initials: H
authors.lastname: Logothetou-Rella
authors.forename: J M
authors.initials: JM
authors.lastname: Nesland
authors.forename: A
authors.initials: A
authors.lastname: Karayiannis
authors.forename: C
authors.initials: C
authors.lastname: Dimopoulos
mesh_terms: D000328:Adult; D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D002455:Cell Division; D002460:Cell Line; D002470:Cell Survival; D006801:Humans; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D008297:Male; D008854:Microscopy, Electron; D014407:Tumor Cells, Cultured; D001743:Urinary Bladder / Q000166:cytology*; D001749:Urinary Bladder Neoplasms / Q000473:pathology*