title: Regional hemodynamic responses to hypoxia in polycythemic dogs.
abstract: Polycythemia increases blood viscosity so that systemic O2 delivery (QO2) decreases and its regional distribution changes. We examined whether hypoxia, by promoting local vasodilation, further modified these effects in resting skeletal muscle and gut in anesthetized dogs after hematocrit had been raised to 65%. One group (CON, n = 7) served as normoxic controls while another (HH, n = 6) was ventilated with 9% O2--91% N2 for 30 min between periods of normoxia. Polycythemia decreased cardiac output so that QO2 to both regions decreased approximately 50% in both groups. In compensation, O2 extraction fraction increased to 65% in muscle and to 50% in gut. When QO2 was reduced further during hypoxia, blood flow increased in muscle but not in gut. Unlike previously published normocythemic studies, there was no initial hypoxic vasoconstriction in muscle. Metabolic vasodilation during hypoxia was enhanced in muscle when blood O2 reserves were first lowered by increased extraction with polycythemia alone. The increase in resting muscle blood flow during hypoxia with no change in cardiac output may have decreased O2 availability to other more vital tissues. In that sense and under these experimental conditions, polycythemia caused a maladaptive response during hypoxic hypoxia.
authors.affiliation: Department of Physiology and Biophysics, University of Alabama, Birmingham 35294.
authors.forename: R L
authors.initials: RL
authors.lastname: Stork
authors.forename: D L
authors.initials: DL
authors.lastname: Bredle
authors.forename: C K
authors.initials: CK
authors.lastname: Chapler
authors.forename: S M
authors.initials: SM
authors.lastname: Cain
mesh_terms: D000818:Animals; D002302:Cardiac Output; D004285:Dogs; D006439:Hemodynamics; D000860:Hypoxia / Q000150:complications / Q000503:physiopathology*; D007413:Intestinal Mucosa / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D010101:Oxygen Consumption; D011086:Polycythemia / Q000150:complications / Q000503:physiopathology*; D012039:Regional Blood Flow; D014655:Vascular Resistance; D014664:Vasodilation