title: Effects of chronic long-acting bromocriptine treatment on liveweight, voluntary food intake, coat growth and breeding season in non-pregnant red deer hinds.
abstract: Seventeen red deer hinds were housed in individual pens and from 28 February until 11 November were injected each week with vehicle (group A; n = 6) or 5 (group B; n = 6) or 12.5 mg (group C; n = 5) of a long-acting formulation of bromocriptine. Liveweight and voluntary food intake (VFI) were recorded for each hind, and blood was collected for determination of progesterone, prolactin, tri-iodothyronine (T3) and cortisol concentrations by radioimmunoassay. Treatment with the high dose of bromocriptine was associated with a significant (P less than 0.05) reduction in VFI, with the effect being greatest between March and July. There was no treatment effect on liveweight, but there was a significant (P less than 0.01) interaction between time and treatment due to the faster rate of weight gain in control animals at the beginning of the experiment. Changes in liveweight could be explained by changes in VFI rather than by changes in the efficiency of utilization of intake. Termination of the breeding season was significantly (P less than 0.01) delayed by 54 days in group C hinds. Growth of the summer coat and subsequent winter coats was delayed by 1 and 3 months respectively in group C hinds, and in groups B and C the duration that animals were in summer coat was increased by about 1 month. The seasonal increase in prolactin concentrations was seen in all groups, but levels were significantly (P less than 0.05) lower in group C hinds. Concentrations of T3 and cortisol were not affected by bromocriptine.
authors.affiliation: MRC/AFRC Comparative Physiology Research Group, Institute of Zoology, Regent's Park, London.
authors.forename: J D
authors.initials: JD
authors.lastname: Curlewis
authors.forename: A S
authors.initials: AS
authors.lastname: Loudon
authors.forename: J A
authors.initials: JA
authors.lastname: Milne
authors.forename: A S
authors.initials: AS
authors.lastname: McNeilly
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D001971:Bromocriptine / Q000494:pharmacology*; D003670:Deer / Q000502:physiology*; D004435:Eating / Q000187:drug effects*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D006197:Hair / Q000187:drug effects; D011388:Prolactin / Q000097:blood; D012621:Seasons; D013997:Time Factors
chemical_list: D001971:Bromocriptine; D011388:Prolactin