title: Five patients with painless thyroiditis simultaneously developed in a nursery school.
abstract: Painless (silent) thyroiditis (PT) occurred simultaneously in 1 male and 4 females aged 21 to 52 years working at a nursery school. Clinical symptoms did not include goiter, or pain or tenderness of the neck in any of the patients but were characterized by edema of the lower legs as well as palpitation and loss of body weight as observed in subacute thyroiditis. General blood analysis showed that all patients were negative for C-reactive protein (CRP) and 3 had mild impairment of liver function. Examination of thyroid function suggested transient thyrotoxicosis accompanied by a marked reduction in radioactive iodine uptake (RAIU), but antithyroglobulin hemagglutination antibody (TGHA) and antithyroid microsomal hemagglutination antibody (MCHA) were negative in all patients. Examination of various viral antibodies showed no significant changes in their titers. Thyrotoxicosis was transient and disappeared without treatment or by glucocorticoid administration. Our results suggested that PT observed in this study was caused by some environmental factor. The possibility of an unidentified virus as a factor cannot be ruled out.
authors.affiliation: Third Department of Internal Medicine Okayama University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ogura
authors.forename: S
authors.initials: S
authors.lastname: Hirakawa
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: Z
authors.initials: Z
authors.lastname: Ota
authors.forename: T
authors.initials: T
authors.lastname: Togawa
authors.forename: I
authors.initials: I
authors.lastname: Nogami
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D012578:Schools, Nursery; D013961:Thyroid Gland / Q000503:physiopathology; D013966:Thyroiditis / Q000188:drug therapy / Q000473:pathology / Q000635:transmission*
chemical_list: D000914:Antibodies, Viral; D011239:Prednisolone