Effect of intra-articular glucocorticoids on the disposition of sulphadimidine in chronic osteoarthritis patients.
1. The disposition of sulphadimidine (15 mg kg-1 orally) was investigated in six chronic osteoarthritis patients (four slow and two fast acetylators) prior to and 4 days following intra-articular administration of glucocorticoids. 2. The mean (+/- s.e. mean) renal clearance of sulphadimidine was increased from 0.03 +/- 0.01 to 0.07 +/- 0.02 ml min-1 kg-1 (P = 0.01) following the administration of intra-articular steroid. 3. Mean metabolic clearance and volume of distribution data were similar on the two study days. However, two of the slow acetylators showed marked increases (63% and 193%) in metabolic clearance following steroid treatment.
Reeves
P T
PT
Department of Pharmacology, University of Western Australia, Nedlands.
Hanrahan
P
P
Edelman
J
J
Ilett
K F
KF
D000107:Acetylation; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006207:Half-Life; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008657:Metabolic Clearance Rate; D008775:Methylprednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077555:Methylprednisolone Acetate; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism*; D013418:Sulfamethazine / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000494:pharmacology*
D000077555:Methylprednisolone Acetate; D013418:Sulfamethazine; D014222:Triamcinolone Acetonide; D008775:Methylprednisolone