title: Age-related changes of noradrenergic innervation of rat splanchnic blood vessels: a histofluorescence and neurochemical study.
abstract: The influence of ageing on the noradrenergic innervation of superior mesenteric artery and vein, renal artery and vein, and portal vein was studied in male Wistar rats by means of catecholamine histofluorescence, image analysis techniques and high pressure chromatography with electrochemical detection. Old age was accompanied by a marked increase in the density of noradrenergic innervation and an increase of noradrenaline levels in superior mesenteric artery, renal artery, and portal vein. In contrast, no significant age-related changes were observed in the density of noradrenergic innervation or in noradrenaline levels in superior mesenteric and renal vein. The present data indicate that, at least in superior mesenteric and renal artery and portal vein, senescence is not accompanied by loss or by lack of change in the noradrenergic innervation as commonly believed to be the case in many vascular trees. On the basis of our findings it cannot be excluded that increased plasma catecholamine levels observed in senescence derive, in part, from perivascular sympathetic endings.
authors.affiliation: Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome, Italy.
authors.forename: M C
authors.initials: MC
authors.lastname: Mione
authors.forename: S L
authors.initials: SL
authors.lastname: Erdö
authors.forename: B
authors.initials: B
authors.lastname: Kiss
authors.forename: A
authors.initials: A
authors.lastname: Ricci
authors.forename: F
authors.initials: F
authors.lastname: Amenta
mesh_terms: D000320:Adrenergic Fibers / Q000254:growth & development* / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001808:Blood Vessels / Q000254:growth & development / Q000294:innervation*; D008297:Male; D008638:Mesenteric Arteries / Q000254:growth & development / Q000378:metabolism; D008642:Mesenteric Veins / Q000254:growth & development / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012077:Renal Artery / Q000254:growth & development / Q000378:metabolism; D012082:Renal Veins / Q000254:growth & development / Q000378:metabolism; D013152:Splanchnic Circulation