Effects of cimetidine and ranitidine on basal gastric pH, free and total acid contents in horses.
The basal gastric pH, free and total acid contents from five adult horses were determined at two-hour intervals for six- to eight-hour periods. The basal gastric pH, free and total acid contents varied from 2.14 +/- 0.08 to 2.41 +/- 0.14, 28.63 +/- 8.27 to 17.89 +/- 2.86 mmol litre-1 and 41.38 +/- 9.72 to 37.38 +/- 3.70 mmol litre-1, respectively. Cimetidine (8.8 mg kg-1 orally) and ranitidine (2.2 mg kg-1 orally) increased the basal gastric pH to above 3.6 (P less than 0.05) with a concomitant reduction of 75 per cent and 75 to 100 per cent in the basal gastric free acid content, respectively, for an eight-hour period. Cimetidine (4.4 mg kg-1, intramuscularly) and ranitidine (1.4 mg kg-1, intramuscularly) increased the basal gastric pH to above 3.6 with a concomitant reduction of 54 to 93 per cent and 69 to 100 per cent in the basal gastric free acid content, respectively, for an eight-hour period. This study shows that the horse is a basal acid secretor, and that cimetidine and ranitidine, two widely used histaminergic-H2 type antagonists in human clinical practice are effective in horses with ranitidine being approximately four times more potent than cimetidine.
Sangiah
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S
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078.
McAllister
C C
CC
Amouzadeh
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HR
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination / Q000662:veterinary; D006736:Horses / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D011899:Ranitidine / Q000494:pharmacology*; D013997:Time Factors
D002927:Cimetidine; D011899:Ranitidine