[Several aspects of the pathogenesis of disturbances of hemostasis in patients with diffuse toxic goiter].
Components of the kallikrein-kinin system of the blood and some hemostatic indices were studied in parallel in 32 patients with diffuse toxic goiter. A decrease in the levels of prekallikrein, kininogen, the activity of kallikrein and kininase inhibitors in the blood plasma of the examinees resulted in raised activity of the kallikrein-kinin system in decompensated thyrotoxicosis. Hemostatic changes were characterized by signs of chronic disseminated intravascular coagulation. It was shown that kinin formation and blood coagulation were correlated. A certain parallelism in the increment of the activity of the kinin system and disorders of hemocoagulation was noted with an increase in a degree of severity of thyrotoxicosis. A tendency to improved indices was also noted after thyrostatic therapy.
Oleĭnik
V A
VA
Matiashina
G I
GI
D000293:Adolescent; D000328:Adult; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000097:blood; D005260:Female; D006042:Goiter / Q000097:blood*; D006487:Hemostasis; D006801:Humans; D007610:Kallikreins / Q000097:blood; D007705:Kinins / Q000097:blood; D008297:Male; D008875:Middle Aged; D013971:Thyrotoxicosis / Q000097:blood
D007705:Kinins; D007610:Kallikreins
Nekotorye storony patogeneza narusheniĭ gemostaza u bol'nykh s diffuznym toksicheskim zobom.