title: Immunisation of pigs with live cultures of Streptococcus suis type 2.
abstract: Repeated intravenous injections of pigs with live virulent cultures of Streptococcus suis type 2 stimulated a strong protective response against subsequent challenge. This protection was transferred passively to susceptible pigs by the inoculation of sera from protected pigs. A strong protective response was also stimulated by repeated inoculations of live cultures of non-pathogenic isolates. The protective response did not eliminate S suis type 2 organisms already established in the tonsils or joints, nor prevent the establishment of subclinical infection in the tonsils.
authors.affiliation: University of Cambridge, Department of Clinical Veterinary Medicine.
authors.forename: M E
authors.initials: ME
authors.lastname: Holt
authors.forename: M R
authors.initials: MR
authors.lastname: Enright
authors.forename: T J
authors.initials: TJ
authors.lastname: Alexander
mesh_terms: D000818:Animals; D001170:Arthritis, Infectious / Q000517:prevention & control / Q000662:veterinary; D007114:Immunization / Q000662:veterinary*; D007116:Immunization, Passive / Q000662:veterinary*; D013290:Streptococcal Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D013291:Streptococcus / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control*