title: Canine osteosarcoma. Treatment by amputation versus amputation and adjuvant chemotherapy using doxorubicin and cisplatin.
abstract: Osteosarcoma was diagnosed in 38 dogs. Thirty-six tumors originated from the appendicular skeleton and two from the axial skeleton. Nineteen of the dogs were treated with amputation alone, and 19 were treated with amputation and adjuvant chemotherapy consisting of doxorubicin and cisplatin. The 36 dogs with appendicular osteosarcoma had complete amputation of the affected limb, whereas the two dogs with osteosarcoma of the axial skeleton had an en bloc resection. The mean survival of the 19 dogs treated with amputation alone was 218 days (median, 175 days). Ten dogs were alive at 6 months and four survived 1 year. None of the dogs survived longer than 16 months. Radiographic lesions consistent with metastatic osteosarcoma were seen after surgery in the nine dogs in which radiographs were taken. The mean survival of the 19 dogs treated with amputation and chemotherapy was 415 days (median, 300 days). Drug toxicity was not observed. Fifteen dogs were alive at 6 months, seven dogs were alive at 1 year, 5 dogs were alive at 2 years, and two dogs were alive at 3 years or longer. One dog is alive and well at 25 months. Radiographic lesions suggestive of metastatic osteosarcoma developed in the other 18 dogs. The 19 dogs treated with amputation and chemotherapy had significantly longer survival times than the dogs treated with amputation alone.
authors.affiliation: Donaldson-Atwood Cancer Center, Animal Medical Center, New York, NY 10021.
authors.forename: G N
authors.initials: GN
authors.lastname: Mauldin
authors.forename: R E
authors.initials: RE
authors.lastname: Matus
authors.forename: S J
authors.initials: SJ
authors.lastname: Withrow
authors.forename: A K
authors.initials: AK
authors.lastname: Patnaik
mesh_terms: D000671:Amputation, Surgical / Q000662:veterinary*; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000601:surgery / Q000662:veterinary*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004283:Dog Diseases / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D004285:Dogs; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy / Q000601:surgery / Q000628:therapy / Q000662:veterinary*; D013997:Time Factors
chemical_list: D004317:Doxorubicin; D002945:Cisplatin