title: [Genetic basis of influenza virus virulence: gene composition and virulence of reassortants between mouse-adapted and nonadapted strains from different subtypes].
abstract: Reassortment analysis of the pneumovirulence for mice marker of influenza virus has been performed. The original A/USSR/90/77 (H1H1) influenza virus strain or its mouse-adapted variant were crossed with a variant of A/Aichi/2/68 (H3N2) influenza virus highly virulent for mice. The reassortant having HA gene of the original A/USSR/90/77 virus and the other genes of the highly virulent A/Aichi/2/68 strain was avirulent for mice, whereas a similar reassortant possessing HA gene of the mouse-adapted A/USSR/90/77 strain was as virulent as A/Aichi/2/68 parent virus. The reasortant having HA and M genes of A/Aichi/2/68 and other genes of the mouse-adapted A/USSR/90/77 was moderately virulent, resembling in this respect the latter parent. The data indicates that changes in the different genes in course of viral adaptation to mice result in a differential acquisition of virulence for mice.
authors.forename: I A
authors.initials: IA
authors.lastname: Rudneva
authors.forename: N N
authors.initials: NN
authors.lastname: Finskaia
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Smirnov
authors.forename: N V
authors.initials: NV
authors.lastname: Kaverin
mesh_terms: D000220:Adaptation, Biological; D000818:Animals; D005814:Genes, Viral; D006389:Hemagglutinins, Viral / Q000235:genetics; D006801:Humans; D009980:Influenza A virus / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology; D051379:Mice; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000235:genetics; D014774:Virulence
chemical_list: D006389:Hemagglutinins, Viral; D012367:RNA, Viral
vernacular_title: Geneticheskie osnovy virulentnosti virusa grippa: gennyĭ sostav i virulentnost' reassortantov mezhdu neadaptirovannymi i adaptirovannymi k mysham shtammami, prinadlezhashchimi k raznym podtipam.