title: [Changes in the function of the cardiovascular system and cerebral circulation in patients poisoned by carbon monoxide and methane].
abstract: Altogether 68 patients with carboxyhemoglobinemia and 58 patients poisoned with methane were investigated. Toxic encephalopathy was observed in all of them: I degree of severity--in 13 patients, II degree in 29, III degree in 24, and IV degree in 60. To control CVS function, indices of central hemodynamics were investigated using methods of whole-body rheography and ECG; a volumetric rate of cerebral circulation was determined. A decrease in volumetric cerebral circulation was noted in patients with encephalopathy, III-IV degree, by 37.5% (carboxyhemoglobinemia) and by 26.1% (methane poisoning). Central hemodynamic disorders were more noticeable in carboxyhemoglobinemia. Multimodality intensive therapy included HBO and drugs to restore cerebral circulation, microcirculation in the brain, cerebral metabolism, and CVS function. Of 126 patients CNS functional restoration without neurological deficiencies was noted in 108 patients, neurological and psychic deficiencies were noted in 9 patients; 9 patients died.
authors.forename: R I
authors.initials: RI
authors.lastname: Novikova
authors.forename: V I
authors.initials: VI
authors.lastname: Chernyĭ
mesh_terms: D000328:Adult; D002249:Carbon Monoxide Poisoning / Q000503:physiopathology*; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003244:Consciousness Disorders / Q000139:chemically induced / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008697:Methane / Q000506:poisoning*; D008875:Middle Aged; D013997:Time Factors
chemical_list: D008697:Methane
vernacular_title: Izmenenie funktsional'nogo sostoianiia serdechno-sosudistoĭ sistemy i mozgovogo krovoobrashcheniia u bol'nykh s otravleniiami okis'iu ugleroda i metanom.