Cloning and sequencing of a beta-thalassemia gene from south China.
A beta-thalassemia gene from a patient with beta+-thalassemia in South China was cloned and sequenced. A four nucleotide (TCTT) deletion in codons 41 and 42 was found. This is the most common beta-thalassemia gene in South China and the first mutant identified on China mainland.
Wang
T
T
Department of Medical Genetics, Peking Union Medical College, Beijing, P.R. China.
Zhou
X Y
XY
Huang
S
S
Wang
S W
SW
Cai
R L
RL
Liu
G Y
GY
Yang
S R
SR
Lo
W H
WH
D000595:Amino Acid Sequence; D001483:Base Sequence; D002681:China; D002872:Chromosome Deletion; D003001:Cloning, Molecular; D006801:Humans; D007223:Infant; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D013789:Thalassemia / Q000235:genetics*