title: Linkage of X-linked nephrogenic diabetes insipidus with DXS52, a polymorphic DNA marker.
abstract: In five families with X-linked nephrogenic diabetes insipidus (NDI), linkage studies with the DNA marker DXS52, defined by probe St14, have shown no recombination with a maximum combined lod score of 6.40. These results assign the NDI gene to the subtelomeric region of the X chromosome long arm. This finding should facilitate identification of carriers and should also be helpful in finding the NDI gene itself.
authors.affiliation: Department of Human Genetics, Catholic University, Nijmegen, The Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: Knoers
authors.forename: H
authors.initials: H
authors.lastname: vd Heyden
authors.forename: B A
authors.initials: BA
authors.lastname: von Oost
authors.forename: L
authors.initials: L
authors.lastname: Monnens
authors.forename: J
authors.initials: J
authors.lastname: Willems
authors.forename: H H
authors.initials: HH
authors.lastname: Ropers
mesh_terms: D004247:DNA / Q000235:genetics*; D003919:Diabetes Insipidus / Q000209:etiology / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics*; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D014960:X Chromosome
chemical_list: D005819:Genetic Markers; D004247:DNA