Corticosteroid-induced cleft palate in short-ear mice.
Corticosteroid-induced facial clefting was examined in short-ear mice (inbred strain SEA/GnJ from Jackson Laboratory). They were found to be gentle, prolific breeders (average litter size 7.3 +/- 2.6), with no increased fetal loss due to treatment. Although they have the most "resistant" H-2 haplotype (H-2d), they were found to be highly susceptible to corticosteroid-induced clefting, demonstrating that loci other than H-2 are involved in susceptibility. The short-ear locus itself is a plausible candidate, given that this gene on chromosome 9 leads to defective mesenchymal condensation, which in turn may render these mice extremely sensitive to teratogen exposure. Another gene or genes on chromosome 9 are also possibilities.
Marazita
M L
ML
Department of Human Genetics, Medical College of Virginia, Richmond, VA 23298.
Jaskoll
T
T
Melnick
M
M
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D002972:Cleft Palate / Q000139:chemically induced*; D005260:Female; D006239:Haplotypes; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D012016:Reference Values; D013045:Species Specificity; D013723:Teratogens; D014222:Triamcinolone Acetonide / Q000031:analogs & derivatives* / Q000633:toxicity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013723:Teratogens; D014222:Triamcinolone Acetonide; C005900:triamcinolone hexacetonide