Steroids 36: synthesis of 16,16-dimethyl-17-ketosteroids and 16,16-dimethyl-17 beta-hydroxysteroids.
Direct conversion of 17-ketosteroids (Ia-f) into 16,16-dimethyl-17 beta-hydroxysteroids (IIa-f) and 16,16-dimethyl-17-ketosteroids (IIIa-f) was achieved with methyl iodide in the presence of NaH.
Wolfling
J
J
Department of Organic Chemistry, Jozsef Attila University, Szeged, Hungary.
Schneider
G
G
Dombi
G
G
D000107:Acetylation; D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D006914:Hydroxysteroids / Q000138:chemical synthesis*; D007664:Ketosteroids / Q000138:chemical synthesis*
D006914:Hydroxysteroids; D007664:Ketosteroids