Substantiating hazardous exposure to asbestos by examination of pulmonary dust.
Substantiation of relevant asbestos risks by microscopic examination sets a lower detection limit at fibres longer than 5 to 10 micron and thicker than 0.5 micron. Such microscopically detectable fibres are, of course, in respect to "total quantity" the insignificant part of the overall dust burden, but apparently a necessary part of the whole fraction when assessing the relevance of exposure. Until now, no epidemiologically conclusive asbestos risks resulting from occupational exposure have been made known solely with fibre fraction below the microscopic detection limit. Demands for supplementary electromicroscopic examination on the basis of case reports of lung parenchyma damage by fibres of a lower calibre than the microscopic detection limit are, therefore, presently without foundation. The subject examinations reveal that substantiation of asbestos risks with light-optical means, using different methods, provides comparable results. Initially, of course, it is surprising to obtain fluctuations in results of 100,000 to 600,000 asbestos particles for the same case. However, one must realize that calculations based on intermediate results are responsible for this range of fluctuation, due to the varying degree of asbestos fibre dispersion in the different sections of the lung and, depending on the method of detection used. Interest on the part of everyday occupational medicine and expert opinion is determined by the need to categorize individual cases into different basic classes of risk by referring to relevant morphological facts, such as substantiation of asbestosis or drawing a borderline between persons with occupational risk and those with a non-occupational risk.(ABSTRACT TRUNCATED AT 250 WORDS)
Eitner
F
F
Pathologisches Institut der Städtischen Kliniken, Dortmund, Federal Republic of Germany.
D001194:Asbestos / Q000032:analysis*; D001195:Asbestosis / Q000473:pathology*; D004391:Dust / Q000032:analysis; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008168:Lung / Q000032:analysis* / Q000473:pathology; D008297:Male
D004391:Dust; D001194:Asbestos