title: Dilated cardiomyopathy: long-term follow-up and predictors of survival.
abstract: To determine long-term survival and the prognostic factors of dilated cardiomyopathy, we retrospectively studied a consecutive series of 111 patients (95 men, 16 women, mean age: 45.5 +/- 8.1 years) undergoing cardiac catheterization and diagnostic coronary angiography from January 1970 to December 1979. The inclusion criteria were: normal coronary angiography, diffuse hypokinesia of the left ventricle and left ventricular ejection fraction less than 50%. Base-line clinical data were collected from the hospital records and follow-up data were obtained from the general practitioners and cardiologists. A questionnaire was sent to all living patients. The length of follow-up ranged from 6 to 16 years. Six patients (5%) were lost to follow-up. At the time of catheterization, a majority of the patients had dyspnea and were in New York Heart Association (NYHA) classes II (41%) and III (31%). Clinical history revealed an excessive alcohol consumption in 56% of the patients. During follow-up, 66 patients (63%) died (heart failure: 37%; sudden death: 19%; non-cardiac death: 15%; unknown cause: 27%). Actuarial survival was 90, 50, and 33% at 1, 5, and 10 years, respectively. Univariate analysis revealed that 10-year mortality was related to: left ventricular ejection fraction less than 30%; left ventricular end-diastolic pressure greater than 10 mm Hg; cardiothoracic ratio greater than 54%; episodes of heart failure; left ventricular end-diastolic volume greater than 200 ml/m2, dyspnea of NYHA class III or IV; absence of smoking; absence of moderate systemic hypertension; electrocardiographic evidence of left ventricular hypertrophy and mean systemic arterial pressure greater than 95 mm Hg.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Cardiologie B, CHU Nancy-Brabois, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Juillière
authors.forename: N
authors.initials: N
authors.lastname: Danchin
authors.forename: S
authors.initials: S
authors.lastname: Briançon
authors.forename: K
authors.initials: K
authors.lastname: Khalife
authors.forename: G
authors.initials: G
authors.lastname: Ethévenot
authors.forename: A
authors.initials: A
authors.lastname: Balaud
authors.forename: J M
authors.initials: JM
authors.lastname: Gilgenkrantz
authors.forename: C
authors.initials: C
authors.lastname: Pernot
authors.forename: F
authors.initials: F
authors.lastname: Cherrier
mesh_terms: D000328:Adult; D001794:Blood Pressure; D006328:Cardiac Catheterization; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume