title: [The temporal organization of the complex nodule in the lymph node].
abstract: The aim of the work is to study rhythmic processes at tissue level in the lymph nodule and in the T-territory adjacent to it in order to reveal temporal interrelations in functioning the germinative center, crown and T-territory. The lymph nodule sections are stained with methylene green-pyronine. Small and middle lymphocytes, immunoblasts, plasmoblasts, immature and mature plasma cells, mitotic figures are taken into account. Spectral composition and rhythmic parameters are determined for each type of the cells in the ultradian, circadian and infradian ranges. Periods, approaching the circadian one, are revealed in the germinative centers for small lymphocytes and immature plasma cells. Practically, for all plasma cells the functional period near to 7 h is found; this attests the presence of the common synchronous rhythm driver. Phase difference of immunoblast, plasmablast, immature plasma cell fluctuation in the germinative centers makes it possible to suppose the time, necessary to transfer the immunoblast into the plasmablast (1.6-2.6 h) and the plasmablast into the immature plasma cell (3 h). Owing to the knowledge of the spectral composition of the rhythmic and parameters of certain components it is possible to approximate the total course of the process. Combination of fluctuations with various periods results in their recurrence in more prolonged time intervals.
authors.forename: T S
authors.initials: TS
authors.lastname: Smirnova
authors.forename: L V
authors.initials: LV
authors.lastname: Ermolina
mesh_terms: D000818:Animals; D002452:Cell Count; D002940:Circadian Rhythm; D008198:Lymph Nodes / Q000166:cytology*; D008214:Lymphocytes / Q000166:cytology; D008264:Macrophages / Q000166:cytology; D008297:Male; D051379:Mice; D008938:Mitosis; D010950:Plasma Cells / Q000166:cytology; D013997:Time Factors
vernacular_title: Vremennáia organizatsiia slozhnogo uzelka limfaticheskogo uzla.