Lack of an association between carcinoma of the stomach and the major histocompatibility complex (HLA) in Cape Coloureds.
A possible genetic contribution to the high incidence of gastric carcinoma in the Cape Coloured population of the Western Cape region of South Africa was investigated. The HLA-A, B, C, DR and DQ antigens were determined with a microcytotoxicity assay, and their frequencies compared in 124 individuals with gastric carcinoma and 4,560 controls. No significant difference was found, thus supporting the view that a genetic component has a minor, if any, role in gastric carcinogenesis.
Martell
R W
RW
Provincial Laboratory for Tissue Immunology, Observatory, Cape Town, South Africa.
van Eeden
P J
PJ
Madden
M V
MV
du Toit
E D
ED
Dent
D M
DM
D044383:Black People / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex; D013019:South Africa; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology
D006680:HLA Antigens