Effect of oxodipine and nifedipine on guinea-pig ileum.
1. The effects of oxodipine, a new dihydropyridine, were studied and compared with those of nifedipine in guinea-pig ileum. 2. Oxodipine and nifedipine, 10(-8)-10(-7) M, produced a dose-dependent inhibition of the contractile responses induced by single pulse stimulation, acetylcholine and histamine. 3. From these experiments it is concluded that oxodipine like nifedipine produced a similar and potent inhibitory effect of the contractile responses induced in guinea-pig ileum.
Martin
M
M
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.
Alfaro
M J
MJ
Tamargo
J
J
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004095:Dihydropyridines / Q000494:pharmacology*; D004558:Electric Stimulation; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D009543:Nifedipine / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D006632:Histamine; C053783:oxodipine; D009543:Nifedipine; D000109:Acetylcholine; D002118:Calcium