Calcium oxalate retinopathy associated with methoxyflurane abuse.
A 34-year-old woman developed a crystalline retinopathy after 2 years of inhalational abuse of methoxyflurane. After the woman developed renal failure, a renal biopsy showed multiple birefringent crystals in the renal tubular lumens, epithelial cells, and interstitium compatible with calcium oxalate. Multiple bright yellow-white crystals were deposited throughout the retina and at the level of the retinal pigment epithelium with a retinal arterial and periarterial predilection. This is the first reported case of methoxyflurane abuse with secondary hyperoxaluria in which there was a widespread retinal distribution of crystalline deposits, especially along the retinal arteries and arterioles.
Novak
M A
MA
Division of Ophthalmology, Case Western Reserve University, School of Medicine, Cleveland, Ohio.
Roth
A S
AS
Levine
M R
MR
D058186:Acute Kidney Injury / Q000473:pathology; D000328:Adult; D001706:Biopsy; D002129:Calcium Oxalate / Q000378:metabolism*; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D006959:Hyperoxaluria / Q000139:chemically induced*; D008733:Methoxyflurane; D012164:Retinal Diseases / Q000209:etiology*; D012171:Retinal Vessels / Q000378:metabolism; D019966:Substance-Related Disorders / Q000150:complications*
D002129:Calcium Oxalate; D008733:Methoxyflurane