N-acetylator phenotypes in hyperthyroidism.
Acetylator phenotypes were determined with sulfamethazine in 114 healthy volunteers, 87 patients with immunogenic hyperthyroidism (Graves' disease) and 38 patients with disseminated thyroid autonomies. About 90% of the patients were females. No significant differences of acetylator phenotypes were observed between female volunteers and hyperthyreotic patients younger than 50 years. The proportion of slow acetylators was higher in older patients. Early and late relapses did not depend on acetylator status.
Siegmund
W
W
Institute of Clinical Pharmacology, University of Greifswald, GDR.
Franke
G
G
Meng
S
S
Gothe
P
P
Meng
W
W
D000107:Acetylation; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013418:Sulfamethazine
D013418:Sulfamethazine