title: [Characteristics of the clinical picture and course of chronic alcoholic intoxication in patients with various types of neuroendocrine changes].
abstract: Clinical and hormonal indices of androgenic activity were compared in 118 males chronically intoxicated with alcohol. The population was divided into two groups with respect to their clinical and hormonal androgenic indices: 76 patients with (Group 1), and 46 patients without (Group 2) androgenic insufficiency. Distinct signs and syndromes of alcohol addiction were shown to correlate with the extent of cross-regulation impairment within hypothalamo-hypophyseo-gonadal system. This was particularly derived from comparison of clinical picture of chronic alcohol intoxication and hormone activity in the groups. Conventional therapy failed to restore the neuroendocrine indices that was apparently due to inhibition of cross-regulation links in the hypothalamo-hypophyseo-gonadal system at several stages of alcohol addiction.
authors.forename: G P
authors.initials: GP
authors.lastname: Kolupaev
authors.forename: V A
authors.initials: VA
authors.lastname: Iakovleva
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D000728:Androgens / Q000172:deficiency; D004700:Endocrine System Diseases / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D000431:Ethanol / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000503:physiopathology; D013375:Substance Withdrawal Syndrome / Q000097:blood / Q000175:diagnosis
chemical_list: D000728:Androgens; D000431:Ethanol
vernacular_title: Osobennosti kliniki i techeniia khronicheskoĭ alkogol'noĭ intoksikatsii u bol'nykh s raznymi tipami neĭroéndokrinnykh izmeneniĭ.