The effect of cocaine on hippocampal cholinergic and noradrenergic metabolism.
Rats treated with L-cocaine HCl exhibited an increase in hippocampal acetylcholine turnover, as measured by a mass fragmentographic technique. Furthermore, the ratio of hippocampal 3-methoxy-4-hydroxyphenylethyleneglycol to norepinephrine increased significantly. Possible mechanisms of the increased cholinergic activity are discussed.
Robinson
S E
SE
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0613.
Hambrecht
K L
KL
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D008734:Methoxyhydroxyphenylglycol; D003042:Cocaine; D000109:Acetylcholine; D009638:Norepinephrine