An evaluation of implanted male Onchocerca gibsoni in mice as a screen for macrofilaricides against Onchocerca volvulus.
An in vivo drug screen for identifying new compounds with activity against Onchocerca macrofilariae was developed using male Onchocerca gibsoni implanted subcutaneously in outbred mice. There were several similarities (Mel W, CGP 20376, CGP 6140, levamisole) and two differences (suramin, furapyrimidone) between levels of drug efficacy in this model and activity against natural infections of O. gibsoni and O. volvulus. There was considerable variation in the mouse reaction. This mouse model is a potentially useful primary screen for macrofilaricidal drugs against Onchocerca.
Vankan
D M
DM
Graduate School of Tropical Veterinary Science, James Cook University of North Queensland, Townsville, Australia.
Copeman
D B
DB
Novak
M
M
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D001152:Arsenicals / Q000494:pharmacology / Q000627:therapeutic use; D005369:Filaricides / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D009854:Onchocerca / Q000187:drug effects*; D009855:Onchocerciasis / Q000188:drug therapy*; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use; D011897:Random Allocation; D013844:Thiazoles / Q000494:pharmacology / Q000627:therapeutic use
D000871:Anthelmintics; D001152:Arsenicals; D005369:Filaricides; D010879:Piperazines; D013844:Thiazoles; C015980:melarsonic acid; C051745:CGP 20376; C051744:amocarzine