title: Single-dose antimicrobial prophylaxis at abdominal hysterectomy. Cefamandole vs. cefotaxime.
abstract: Two hundred twenty-three women were given a single, 1-g, intravenous dose of cefamandole or cefotaxime at elective abdominal hysterectomy in a multicenter, prospective, randomized, blind clinical trial of efficacy and safety. The demographic, surgical, efficacy and safety variables were statistically similar. Prior to discharge from the hospital, 12 women (5.3%) developed major postoperative pelvic infections that required parenteral antimicrobial therapy; no wound infections occurred. There was no correlation between a depressed antimicrobial development of significant postoperative infection. An expanded spectrum of antibacterial activity and a longer serum half-life did not improve clinical efficacy, and single-dose intravenous cephalosporin prophylaxis before abdominal hysterectomy was associated with a low incidence of pelvic infection.
authors.affiliation: Department of Obstetrics and Gynecology, University of Texas Health Science Center, Dallas.
authors.forename: D L
authors.initials: DL
authors.lastname: Hemsell
authors.forename: J N
authors.initials: JN
authors.lastname: Martin
authors.forename: J G
authors.initials: JG
authors.lastname: Pastorek
authors.forename: B J
authors.initials: BJ
authors.lastname: Nobles
authors.forename: P G
authors.initials: PG
authors.lastname: Hemsell
authors.forename: N
authors.initials: N
authors.lastname: Helman
authors.forename: P
authors.initials: P
authors.lastname: Blake
authors.forename: M K
authors.initials: MK
authors.lastname: Lindsey
authors.forename: S K
authors.initials: SK
authors.lastname: Nicaud
mesh_terms: D000328:Adult; D002435:Cefamandole / Q000008:administration & dosage / Q000627:therapeutic use*; D002439:Cefotaxime / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D008875:Middle Aged; D000292:Pelvic Inflammatory Disease / Q000209:etiology / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D011897:Random Allocation; D014946:Wound Infection / Q000517:prevention & control*
chemical_list: D002435:Cefamandole; D002439:Cefotaxime