A clone with a chromosome abnormality, i(17q), in the myeloid crisis of chronic myeloid leukemia is able to differentiate into neutrophil, basophil and eosinophil lineages.
Simultaneous cytogenetic and morphologic observations of single colonies derived from granulocytic precursor cells were performed on a patient with chronic myelogenous leukemia (CML) during the myeloid crisis. Colonies having a Ph1 chromosome and i(17q) were found to consist of neutrophilic/basophilic, eosinophilic/basophilic or basophilic granulocytes. These findings led to the conclusion that cells having the additional abnormality, i(17q), are still able to differentiate into neutrophil, basophil and eosinophil lineages. In other words, this chromosome abnormality does not give a proliferative advantage to a restricted cell lineage.
Yokota
S
S
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine.
Okuda
T
T
Sonoda
Y
Y
Maekawa
T
T
Misawa
S
S
Takino
T
T
Abe
T
T
D000328:Adult; D001752:Blast Crisis / Q000097:blood / Q000235:genetics*; D002869:Chromosome Aberrations / Q000097:blood / Q000235:genetics*; D025063:Chromosome Disorders; D002886:Chromosomes, Human, Pair 17; D002999:Clone Cells / Q000166:cytology; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000235:genetics*; D008677:Metaphase