(Butylthio)carbonyl group: a new protecting group for the guanine and uracil residues in oligoribonucleotide synthesis.
The protection of the O6-amide and N2-amino groups of guanosine and the N3-imide group of uridine with the (butylthio)carbonyl group is described. This group could be rapidly introduced in good yields and removed very easily under the conventional deprotective conditions of the exo-amino acyl groups of other nucleoside bases.
Yamakage
S
S
Department of Industrial Chemistry, Chiba Institute of Technology, Japan.
Fujii
M
M
Horinouchi
Y
Y
Takaku
H
H
D001483:Base Sequence; D006147:Guanine; D007202:Indicators and Reagents; D015394:Molecular Structure; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D014498:Uracil
D007202:Indicators and Reagents; D009843:Oligoribonucleotides; D014498:Uracil; D006147:Guanine