[Effect of prostaglandin E1 on the formation of experimental arterial and venous thrombosis].
The effect of prostaglandin E1 on thrombus formation and haemostasis was investigated in a standardized experimental model in 20 rabbits. Arterial thrombus formation was reduced significantly by 70% and venous thrombosis by 68% in comparison with the controls. Collagen- and ADP-induced platelet aggregation was also inhibited significantly. Additionally, the time lag until onset of collagen-induced aggregation was significantly prolonged. Platelet count however, and plasma coagulation time showed no change. The data demonstrate a clear inhibition of arterial and venous thrombus formation, suggesting a powerful antithrombotic activity of prostaglandin E1. The effect may be explained by an influence on platelet function. The data further indicate that a full antithrombotic effect is achieved during prostaglandin E1 infusion.
Zimmermann
R
R
Medizinische Universitätsklinik Heidelberg, Bundesrepublik Deutschland.
Stadler
J
J
Harenberg
J
J
Kübler
W
W
D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D007260:Infusion Pumps; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D013924:Thrombophlebitis / Q000097:blood*; D013927:Thrombosis / Q000097:blood*
D000527:Alprostadil
Einfluss von Prostaglandin E1 auf die experimentelle arterielle und venöse Thrombenbildung.