Elevated concentration of 5-hydroxytryptamine in ultrafiltrate of human liver vein plasma after infusion of amino acids.
Intragastric infusion of amino acids causes the release from the liver of a factor with stimulatory effect on smooth muscle. The effect of liver vein plasma ultrafiltrate was tested on isolated preparations of rat fundus. The ultrafiltrates collected after amino acid infusion had a 3-5 times higher stimulatory effect on smooth muscle contraction than those collected from control plasma. The active principle was isolated, purified by different chromatographic procedures and identified as 5-hydroxytryptamine (serotonin). No other compound with contractile effect on smooth muscle was detected.
Zimmerman
L
L
Department of Renal Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.
Alvestrand
A
A
Bergström
J
J
D000328:Adult; D000596:Amino Acids / Q000008:administration & dosage*; D005260:Female; D006503:Hepatic Veins; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D012701:Serotonin / Q000302:isolation & purification* / Q000494:pharmacology; D014462:Ultrafiltration
D000596:Amino Acids; D012701:Serotonin