Effect of the excess of thyroid hormone administration on water and sodium chloride intake in the rat.
By using the two-bottle, self-selection method it was found that an excess of thyroid hormone administration to rats increased water and sodium intake. Thyroidectomy changed the initial preference from water to sodium chloride. Oral treatment of the thyroidectomized rats with thyroid hormones brought salt ingestion back to normal levels and greatly augmented the water intake. Two-week treatment was followed by an increase in salt intake, which was characterized by large oscillations resembling the corresponding effects of adrenalectomy and treatment with deoxycorticosterone.
Belló
A A
AA
Departamento de Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Covian
M R
MR
D000818:Animals; D004327:Drinking Behavior / Q000187:drug effects*; D005260:Female; D051381:Rats; D012016:Reference Values; D012965:Sodium Chloride; D013961:Thyroid Gland / Q000502:physiology*; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D012965:Sodium Chloride; D013974:Thyroxine