[Analysis of the correlation between hydrophilic-lipophilic balance, coefficient of diffusion and hydrogen ion concentration in a series of nonsteroidal anti-inflammatory drugs].
A thorough investigation on the dependence of rate diffusion constants (Kd) of nonsteroidal antiinflammatory drugs on pH and pKa values was carried out. It is shown that a modified multiparametric curve-fitting technique may constitute an useful tool to describe the rate diffusion pH-profiles of ionogenic substances. A comparison between the Kd values and the corresponding distribution coefficients (log D) shows that these constants identify complementary parameters very useful in the study of structure-activity relationships of ionogenic substances.
La Rotonda
M I
MI
Istituto di Chimica Farmaceutica, Tossicologica ed Applicata, Università di Cagliari.
Cappello
B
B
Grimaldi
M
M
Silipo
C
C
Vittoria
A
A
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004058:Diffusion; D006863:Hydrogen-Ion Concentration; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal
Analisi correlativa fra bilancio idrofilo-lipofilo, coefficiente di diffusion e concentrazione idrogenionica in una serie di farmaci antiinfiammatori non steroidei.