[Respiration of mitochondria from brown fat and the mechanism of thermogenesis].
It is shown that both phosphorylating and nonphosphorylating (noncoupled) respirations, the latter being regulated by GDP and increasing in a series of substrates - pyruvate + malate----succinate----NADH----ascorbate(+ cytochrome c) have been presented in brown fat mitochondria of newborn guinea pigs and of adult rats under thermoneutral conditions. Noncoupled respiration is suggested to support thermogenesis not only under cold exposure but under thermoneutral conditions as well.
Akhmerov
R N
RN
Makhmudov
E S
ES
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D001833:Body Temperature Regulation; D006153:Guanosine Diphosphate / Q000378:metabolism; D006168:Guinea Pigs; D008928:Mitochondria / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D011048:Polarography; D051381:Rats; D013379:Substrate Specificity
D009243:NAD; D006153:Guanosine Diphosphate; D001205:Ascorbic Acid
Dykhanie mitokhondriĭ buroĭ zhirovoĭ tkani i mekhanizm termogeneza.