[Isothiobarbamine prevention of disorders of carbohydrate and oxygen metabolism and of the development of brain edema in the early period after an intracerebral hemorrhage].
In experiments on cats after injection of isothiobarbamine intravenously (50 mg/kg) at 30 min, intracerebral hemorrhage prevented activation of brain glucose utilization, depression of brain oxygen utilization, surplus lactate accumulation in brain, early development of brain edema and death of cats.
Plotnikov
M B
MB
Plotnikova
T M
TM
Iakimova
T V
TV
Saratikov
A S
AS
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001929:Brain Edema / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D050260:Carbohydrate Metabolism; D002415:Cats; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005947:Glucose / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D010101:Oxygen Consumption / Q000187:drug effects*; D013858:Thiobarbiturates / Q000627:therapeutic use*; D013997:Time Factors
D007773:Lactates; D013858:Thiobarbiturates; D019344:Lactic Acid; C050596:isothiobarbamin; D005947:Glucose
Preduprezhdenie izotiobarbaminom narusheniĭ uglevodnogo, kislorodnogo obmena i razvitiia oteka mozga v rannie sroki posle vnutrimozgovogo krovoizliianiia.