Intestinal microflora of BALB/c-mice and function of local immune cells.
BALB/c-mice were treated for 7 days with oral nonabsorbable dosages of mezlocillin to achieve digestive tract decontamination. Such a procedure resulted in rapid eradication of most species of aerobic and anaerobic intestinal microflora. Various functions of peritoneal macrophages (e.g. chemiluminescence response, chemotactic motility, bactericidal and cytostatic ability) and lymphocyte proliferation were decreased in decontaminated animals as compared to non-treated controls.
Roszkowski
K
K
National Institute for Lung Diseases, Warsaw, Poland.
Ko
H L
HL
Beuth
J
J
Ohshima
Y
Y
Roszkowski
W
W
Jeljaszewicz
J
J
Pulverer
G
G
D000818:Animals; D001419:Bacteria / Q000187:drug effects / Q000276:immunology*; D005243:Feces / Q000382:microbiology; D007422:Intestines / Q000276:immunology / Q000382:microbiology*; D008175:Lung Neoplasms; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008802:Mezlocillin / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D012513:Sarcoma, Experimental; D014407:Tumor Cells, Cultured
D008802:Mezlocillin