Effect of erythropoietin on membrane lipid peroxidation, superoxide dismutase, catalase, and glutathione peroxidase of rat RBC.
Starved animals having low levels of erythropoietin in blood showed increased MDA, fluorescent pigments, and met-Hb values whereas the hemoglobin concentration decreased significantly on starvation. In vivo and in vitro studies with Ep reversed the effects of starvation and brought these values close to normal. The activities of the enzymes (SOD, catalase, GSH-PX, GR G6PD, and 6PGD) which protect the RBC membrane directly or indirectly from peroxidative threat, decreased on starvation and restored to normal levels after Ep treatment.
Chakraborty
M
M
Indian Institute of Chemical Biology, Calcutta.
Ghosal
J
J
Biswas
T
T
Datta
A G
AG
D000818:Animals; D002374:Catalase / Q000097:blood*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure; D004921:Erythropoietin / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000097:blood*; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D008563:Membrane Lipids / Q000097:blood*; D008854:Microscopy, Electron; D051381:Rats; D012016:Reference Values; D013217:Starvation; D013482:Superoxide Dismutase / Q000097:blood*
D008563:Membrane Lipids; D004921:Erythropoietin; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase