[A substance with antibacterial and antifungal activity. IV. Synthesis and microbiological activity of new 1,5-diarylpyrrole derivatives].
The synthesis and antifungal activities of new 1,5-diarylpyrrole derivatives are reported. Antimicrobial data in comparison with pyrrolnitrin show that only carboxamide derivatives exhibit satisfactory antifungal activity. By contrast all tested compounds show very poor antibacterial activity. The displacement of NO2 group from para to meta or ortho position of the aryl at C5 of the pyrrole ring affects the antimicrobial activity.
Scalzo
M
M
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università La Sapienza, Roma.
Porretta
G C
GC
Chimenti
F
F
Casanova
M C
MC
Panico
S
S
Simonetti
N
N
D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis*; D008826:Microbial Sensitivity Tests; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D011758:Pyrroles
Ricerche su sostanze ad attività antibatterica ed antifungina. Nota IV--Sintesi ed attività microbiologica di nuovi derivati 1,5-diarilpirrolici.