Polyanhydride microsphere formulation by solvent extraction.
A novel process based on solvent extraction was developed to produce drug-loaded polyanhydride microspheres for controlled-release applications. The technique consists of adding a chloroform solution of polyanhydride and drug into a stirred silicone oil phase containing suspended droplets of surfactant. No chemical reaction, heating, nor contact with water was required in this process. The microspheres produced were capable of releasing various dyes for prolonged periods of time.
Bindschaedler
C
C
Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge 02139.
Leong
K
K
Mathiowitz
E
E
Langer
R
R
D000812:Anhydrides / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004396:Coloring Agents; D008863:Microspheres; D010316:Particle Size; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet
D000812:Anhydrides; D004396:Coloring Agents; D012997:Solvents