Age-related auditory brainstem response (ABR) threshold changes in the dancer mouse mutant.
An age-related analysis of auditory brainstem response (ABR) thresholds in 42 heterozygotic dancer mouse mutants (1-13 months old) showed an impairment of ABR thresholds with increasing age, though individual threshold curves could vary considerably. As compared with normal CBA/CBA mice, a progressive deterioration of ABR thresholds occurred from the 2nd postnatal month onwards. The dancer mutant has an inner ear with a morphogenetic type of defect, caused by a semidominant gene which is located in chromosome 19.
Wenngren
B I
BI
Department of Oto-Rhino-Laryngology, University Hospital, Umeå, Sweden.
Anniko
M
M
D000375:Aging / Q000502:physiology*; D000818:Animals; D001309:Auditory Threshold / Q000502:physiology*; D001933:Brain Stem / Q000502:physiology; D003638:Deafness / Q000235:genetics*; D005072:Evoked Potentials, Auditory; D005799:Genes, Dominant; D051379:Mice; D008808:Mice, Inbred CBA; D008818:Mice, Neurologic Mutants / Q000502:physiology*; D011817:Rabbits