Association of HLA-Bw61 with asthma in the Chinese.
HLA-A and -B typings were detected in 93 asthmatic and 98 normal subjects, all of them of Han nationality, in Shenyang. Antigen frequencies of HLA-A9, A10, Bw61 and Bw62 were found to be much higher than those of normal controls, and -A3 much lower (p less than 0.05). However, after the p-values were corrected, the significant difference was only existing in HLA-Bw61 (pc less than 0.01) with a relative risk of 6.6 (HLA frequencies were 0.2366 and 0.0408 in patient group and control, respectively). Our results indicate a significant association between HLA-Bw61 and the asthmatic patients of Han nationality in Shenyang area, North-east China.
Wang
W X
WX
Department of Internal Medicine, No. 202 Hospital, Shenyang, P.R.C.
Yang
S Z
SZ
Chui
X W
XW
Zhang
H L
HL
D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000276:immunology*; D002681:China; D005260:Female; D005828:Genetics, Population; D015235:HLA-B Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007125:Immunogenetics; D008297:Male; D008875:Middle Aged
D015235:HLA-B Antigens; C079077:HLA-B61 antigen