The effect of mazindol on growth hormone secretion in boys with Duchenne muscular dystrophy.
Mazindol has been reported to improve muscle function in Duchenne muscular dystrophy (DMD) by virtue of its growth hormone (GH) suppression. The effects were studied on GH secretion (in response to growth hormone releasing factor and sleep) of mazindol 2 mg daily for 3 months in five boys with DMD. No consistent change was found following mazindol therapy. Adverse effects were noted in all the boys which may preclude long term use of mazindol in DMD.
Coakley
J H
JH
University Department of Medicine, Royal Liverpool Hospital, UK.
Moorcraft
J
J
Hipkin
L J
LJ
Smith
C S
CS
Griffiths
R D
RD
Edwards
R H
RH
D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008454:Mazindol / Q000009:adverse effects / Q000627:therapeutic use*; D009136:Muscular Dystrophies / Q000097:blood / Q000188:drug therapy*; D011863:Radioimmunoassay
D007211:Indoles; D013006:Growth Hormone; D008454:Mazindol