Influence of oral contraceptive treatment on blood pressure and 24-hour urinary catecholamine excretion in smoking as compared with non-smoking women.
Microgynon-30 was administered to 15 smoking (group B) and 14 non-smoking young women (group A) for a period of 4 months. Prior to the institution of treatment supine blood pressure and daily urinary catecholamine excretion (DUCE) were measured in both groups of patients. Both values were elevated in group B in comparison with group A. Treatment with Microgynon-30 for 4 months induced a significant increase in DUCE in both groups, the increase being most marked in group B (p less than 0.0004). The increased catecholamine excretion accompanied small non-significant elevations in blood pressure. It is concluded that treatment with low-dosage estrogen oral contraceptives produces a significant increase in daily catecholamine excretion, especially in patients who smoke.
Blum
M
M
Family Planning Clinic, Mishmar Hayarden, Kupat Holim Sick Fund, Israel.
Zacharovich
D
D
Gelernter
I
I
Blum
I
I
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage / Q000009:adverse effects*; D004837:Epinephrine / Q000652:urine*; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000009:adverse effects*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D006801:Humans; D009638:Norepinephrine / Q000652:urine*; D009644:Norgestrel / Q000008:administration & dosage / Q000009:adverse effects*; D012907:Smoking / Q000652:urine*
D003278:Contraceptives, Oral, Hormonal; D009644:Norgestrel; D004997:Ethinyl Estradiol; D019304:Ethinyl Estradiol-Norgestrel Combination; D009638:Norepinephrine; D004837:Epinephrine