Chromosomal aberrations induced by secondary and tertiary amine-containing dyes and in combination with nitrite in vivo in mice.
Chromosomal aberrations induced by indigo carmine (secondary amine-containing dye), fast green FCF (tertiary amine-containing dye) and sodium nitrite, singly and in combination, were studied in mice after prolonged feeding in the diet. A significant increase in the chromosomal aberrations was observed for all the dyes and in the nitrite treated series when compared with distilled water controls. However, a combination of half the concentration of dye and nitrite gave additive effects.
Das
S K
SK
Department of Zoology, Narasinha Dutt College, Howrah, India.
Giri
A K
AK
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D004396:Coloring Agents / Q000032:analysis / Q000494:pharmacology*; D007203:Indigo Carmine / Q000032:analysis / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009573:Nitrites / Q000494:pharmacology*; D012394:Rosaniline Dyes / Q000032:analysis / Q000494:pharmacology
D004396:Coloring Agents; D009573:Nitrites; D012394:Rosaniline Dyes; C035906:Fast Green; D007203:Indigo Carmine