Amyloid angiopathy and granulomatous angiitis of the central nervous system: a case responding to corticosteroid treatment.
A 73-year-old woman presented with multifocal cerebral dysfunction of 1 month's duration. Cranial CT scanning revealed unusual widespread abnormalities. Brain biopsy showed amyloid angiopathy affecting vessels in the meninges and cerebral cortex, with associated granulomatous angiitis. There was no clinical evidence of extracranial vasculitis. Corticosteroid therapy produced striking clinical and radiological improvement.
Ginsberg
L
L
Department of Neurology, Royal Free Hospital, London, UK.
Geddes
J
J
Valentine
A
A
D000368:Aged; D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D014057:Tomography, X-Ray Computed; D014657:Vasculitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology
D000682:Amyloid; D003907:Dexamethasone