title: In vitro activity of pefloxacin compared with five other quinolones on nalidixic acid-resistant proteae species.
abstract: The in vitro activity of pefloxacin, a new fluoroquinolone, was compared with that of 5 other quinolone compounds (nalidixic and pipemidic acids, norfloxacin, ciprofloxacin, and ofloxacin) against 416 strains of Proteae spp. isolated from urine specimens of hospitalized patients with acute urinary tract infections (UTI). Ciprofloxacin was the most active agent. Norfloxacin, ofloxacin, and pefloxacin were similarly active against Proteus strains (MIC90 = 0.39 microgram/ml). Against Providencia spp. pefloxacin and norfloxacin showed similar activity (MIC90 = 3.12 micrograms/ml). There is minimal discrepancy between minimum inhibitory concentrations and minimum bactericidal concentrations exhibited by the quinolones for all urinary tract pathogens tested. Our in vitro studies indicate that pefloxacin is an active antimicrobial agent and suggest that it will prove useful in the treatment of complicated urinary tract infections due to nalidixic acid-resistant Proteae spp.
authors.affiliation: Istituto di Medicina Sperimentale, Facoltà di Medicina e Chirurgia, Università G. D'Annunzio, Chieti, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Piccolomini
authors.forename: L
authors.initials: L
authors.lastname: Cellini
authors.forename: N
authors.initials: N
authors.lastname: Allocati
authors.forename: A
authors.initials: A
authors.lastname: Di Girolamo
authors.forename: L
authors.initials: L
authors.lastname: Selan
authors.forename: F
authors.initials: F
authors.lastname: Scazzocchio
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology*; D009643:Norfloxacin / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology; D015366:Pefloxacin / Q000494:pharmacology*; D010876:Pipemidic Acid / Q000494:pharmacology; D011511:Proteus / Q000187:drug effects* / Q000302:isolation & purification; D011532:Providencia / Q000187:drug effects* / Q000302:isolation & purification; D014552:Urinary Tract Infections / Q000382:microbiology
chemical_list: D000890:Anti-Infective Agents; D015366:Pefloxacin; D009268:Nalidixic Acid; D002939:Ciprofloxacin; D015242:Ofloxacin; D010876:Pipemidic Acid; D009643:Norfloxacin