Ethanol induced skeletal muscle degeneration--role of calcium.
The ethanol induced skeletal muscle degeneration is multi-factorial. The morphological changes of the skeletal muscle are more pronounced in the mitochondria. The excessive concentration of calcium in the mitochondria, as shown by the electron-probe micro-analysis, within the first week of ethanol intoxication, even before the appearance of ultrastructural changes suggests that the calcium influx provokes the mitochondrial degeneration.
Baruah
J K
JK
Department of Neurology, Medical College of Wisconsin, Milwaukee 53226.
Washington
M
M
Kinder
D
D
D000437:Alcoholism / Q000473:pathology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004577:Electron Probe Microanalysis; D000431:Ethanol / Q000633:toxicity*; D008297:Male; D008854:Microscopy, Electron; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000648:ultrastructure; D009132:Muscles / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D000431:Ethanol; D002118:Calcium