Prenatal exposure of male mice to diethylstilbestrol alter the expression of the lactotransferrin gene in seminal vesicles.
We have previously isolated an estrogen-inducible secretory protein, lactotransferrin (LTF), and a cDNA to its messenger RNA from the uterus of mice. In this report we determined that the level of LTF mRNA is minimal in the seminal vesicles of normal mice. In contrast, expression of LTF mRNA in the seminal vesicles of developmentally estrogenized males was both constitutive and estrogen inducible. The results suggested that this alteration may be an example of atypical gene expression after hormonal manipulation early in development.
Pentecost
B T
BT
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709.
Newbold
R R
RR
Teng
C T
CT
McLachlan
J A
JA
D000728:Androgens / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004967:Estrogens / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D005819:Genetic Markers / Q000235:genetics; D007781:Lactoferrin / Q000235:genetics*; D007782:Lactoglobulins / Q000235:genetics*; D008297:Male; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D029584:Prostatic Secretory Proteins; D011506:Proteins / Q000235:genetics; D029589:Seminal Plasma Proteins; D012669:Seminal Vesicles / Q000187:drug effects* / Q000378:metabolism
D000728:Androgens; D004967:Estrogens; D005819:Genetic Markers; D007782:Lactoglobulins; D029584:Prostatic Secretory Proteins; D011506:Proteins; D029589:Seminal Plasma Proteins; C043076:beta-microseminoprotein; D004054:Diethylstilbestrol; D007781:Lactoferrin