title: Serum concentrations and accumulation of silver in skin during three months treatment with an anti-smoking chewing gum containing silver acetate.
abstract: Silver acetate chewing gum was used for 12 weeks as a smoking deterrent in 21 adults. The effect of silver on serum concentrations, its accumulation in the skin and the risk of developing clinically evident argyria were investigated. Serum concentrations of silver clearly rose after chewing gum use had started, and concentrations quickly returned to normal after use had ceased. In most cases the number of silver granules in skin biopsies, observed by autometallography, increased after the gum had been used for 12 weeks. No one developed clinical signs of argyria. Silver acetate containing remedies can be used as an aid to stop smoking, but the consumption must be monitored to avoid accumulation of larger amounts of silver in the body.
authors.affiliation: Department of Respiratory Medicine, University Hospital, Aarhus, Denmark.
authors.forename: E J
authors.initials: EJ
authors.lastname: Jensen
authors.forename: J
authors.initials: J
authors.lastname: Rungby
authors.forename: J C
authors.initials: JC
authors.lastname: Hansen
authors.forename: E
authors.initials: E
authors.lastname: Schmidt
authors.forename: B
authors.initials: B
authors.lastname: Pedersen
authors.forename: R
authors.initials: R
authors.lastname: Dahl
mesh_terms: D000085:Acetates / Q000009:adverse effects / Q000378:metabolism*; D019342:Acetic Acid; D000293:Adolescent; D000328:Adult; D001129:Argyria / Q000209:etiology; D002638:Chewing Gum; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012834:Silver / Q000097:blood*; D012867:Skin / Q000378:metabolism*; D012907:Smoking / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000085:Acetates; D002638:Chewing Gum; D012834:Silver; D019342:Acetic Acid