Prostaglandins in type II collagen-induced ear diseases.
This study examines the role of prostaglandins in type II collagen-induced inner ear disease. Hartley guinea pigs were immunized with type II collagen in complete Freund's adjuvant. Auditory brain stem response was measured initially and at 2, 3, 4, and 6 months after immunization. The presence of PGE2 and 6-keto-PGF1 alpha in the perilymph was determined by radioimmunoassay. Perilymph from immunized animals contained about five times more PGE2 and about three times more 6-keto-PGF1 alpha than the perilymph from control animals. However, the two groups showed no difference in the level of either PGE2 or 6-keto-PGF1 alpha in cerebrospinal fluid and serum. Immunized guinea pigs also showed evidence of hearing loss. The temporal bones showed the following changes: spiral ganglion degeneration; mild to moderate degeneration in the organ of Corti; and infrequent and very mild endolymphatic hydrops. Thus, prostaglandins might play an important role in the pathogenesis of type II collagen-induced inner ear disease.
Kitano
H
H
Veterans Administration Medical Center, Department of Medicine, Memphis, TN.
Takeda
T
T
Chiang
T M
TM
Yoo
T J
TJ
D000818:Animals; D001309:Auditory Threshold; D003094:Collagen / Q000276:immunology*; D004427:Ear Diseases / Q000209:etiology*; D004432:Ear, Middle; D005260:Female; D006168:Guinea Pigs; D010498:Perilymph / Q000032:analysis / Q000276:immunology / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis
D011453:Prostaglandins; D003094:Collagen