title: Amnion rupture sequence in previable fetuses.
abstract: Amnion rupture sequence is considered an uncommon, sporadic condition among liveborn infants. We have examined 1,010 previable fetuses (9-20 weeks developmental age) to determine the incidence and nature of amnion rupture sequence at this stage of development. We found 18 affected fetuses (15 spontaneous and 3 induced abortions) with the incidence of 1:56. Eleven fetuses had limb constrictions and amputations only; 7 fetuses also had nonlimb involvement, including disruptions of the craniofacial region mimicking encephalocele, unusual facial clefts, and abdominal defects. In 6 pregnancies, constrictions of the umbilical cord by amniotic bands were the cause of fetal intrauterine death.
authors.affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
authors.forename: D K
authors.initials: DK
authors.lastname: Kalousek
authors.forename: S
authors.initials: S
authors.lastname: Bamforth
mesh_terms: D000028:Abortion, Induced; D000022:Abortion, Spontaneous; D000650:Amnion / Q000473:pathology*; D000652:Amniotic Band Syndrome / Q000196:embryology* / Q000473:pathology; D000013:Congenital Abnormalities / Q000196:embryology* / Q000473:pathology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000150:complications* / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010920:Placenta / Q000473:pathology; D011247:Pregnancy