title: Inhalation injury in burned patients: effects and treatment.
abstract: Pulmonary pathology in major thermal injury is found in 30-80 per cent of burn fatalities. The incidence and mortality from inhalation injury increases both with age and increasing burn size. Toxic smoke inhalation injury, characterized by increased lung microvascular permeability, is attenuated by increasing cardiac output to normal levels, indicating that fluid restriction after inhalation injury may lead to excessive lung fluid formation and hypoxia. Fluid administration of approximately 2 ml/kg/% area burned above the calculated resuscitation volume is required following an inhalation injury to provide adequate support for the systemic circulation and maintain cardiac output at normal levels. This additional volume does not contribute to the development of pulmonary oedema, but may decrease its formation by increasing shear forces thus reducing polymorphonuclear leucocyte deposition in the pulmonary microcirculation. Nasotracheal intubation is preferred when airway integrity is compromised by inhalation injury. The advantages are non-operative placement, ease of discontinuation, minimal bacterial contamination and leaving neck burns undisturbed. The administration of the appropriate antibiotics for documented infection is recommended, while steroids have been shown to be of no benefit.
authors.affiliation: Shriners Burns Institute, Galveston, Texas.
authors.forename: D N
authors.initials: DN
authors.lastname: Herndon
authors.forename: R E
authors.initials: RE
authors.lastname: Barrow
authors.forename: H A
authors.initials: HA
authors.lastname: Linares
authors.forename: R L
authors.initials: RL
authors.lastname: Rutan
authors.forename: T
authors.initials: T
authors.lastname: Prien
authors.forename: L D
authors.initials: LD
authors.lastname: Traber
authors.forename: D L
authors.initials: DL
authors.lastname: Traber
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002056:Burns / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011654:Pulmonary Edema / Q000209:etiology; D015208:Smoke Inhalation Injury / Q000150:complications / Q000628:therapy*; D014139:Tracheostomy