[Induction of the antileukemic activity in nonimmune allogeneic splenocytes using spleen hemoregulators].
The leukemic mice treated with cyclophosphamide were injected twice a week with the allogenic splenocytes treated for 4 h with the substance isolated from the calf spleen. The leukemia growth inhibition was observed. Syngenic splenocytes were inactive. Allogenic but not syngenic splenocytes manifested a certain antileukemic activity observed in the Winn neutralization and 51Cr release tests, however this activity did not correlate quantitatively with more pronounced antileukemic action of cells in vivo.
Svirnovskiĭ
A I
AI
Shimanskaia
T V
TV
Bakun
A V
AV
Ageĭchik
V M
VM
D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use; D003602:Cytotoxicity, Immunologic; D007694:Killer Cells, Natural / Q000276:immunology*; D007942:Leukemia, Experimental / Q000276:immunology* / Q000628:therapy; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology / Q000276:immunology* / Q000637:transplantation; D014020:Tissue Extracts / Q000627:therapeutic use*; D014184:Transplantation, Homologous
D014020:Tissue Extracts; D003520:Cyclophosphamide
Induktsiia protivoleĭkoznoĭ aktivnosti u neimmunnykh allogennykh splenotsitov s pomoshch'iu gemoregulinov iz selezenki.