[Synthesis and antifungal activity of new derivatives of 5-(4-halobenzoyl)-4-amino-3-(2-dialkylaminoethylthio)thieno [2,3-c] and [3,2-d] isothiazole].
A new series of 5-(4-halobenzoyl)-4-amino-3-(2-dialkylamino-ethylthio)thieno [2,3-c] and [3,2-d] isothiazole derivatives has been synthetized. The compounds were evaluated for antifungal activity on yeast and dermatophytes. The compound (VI b) resulted about thirty times less potent than miconazole on dermatophytes.
Romeo
G
G
Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania.
Bousquet
E
E
Pappalardo
M S
MS
Ronsisvalle
G
G
Oliveri
S
S
Cammarata
E
E
D000935:Antifungal Agents / Q000138:chemical synthesis*; D001565:Benzoates / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
D000935:Antifungal Agents; D001565:Benzoates; D013844:Thiazoles; D013876:Thiophenes
Sintesi ed attività antifungina di nuovi derivati 5-(4-alobenzoil)-4-ammino-3-(2-dialchilamminoetiltio)tieno [2,3-c] e [3,2-b] isotiazolici.