The effect of Permixon on androgen receptors.
Permixon, the liposterolic extract of the plant Serenoa Repens is a recently introduced drug for the treatment of benign prostatic hyperplasia. The effect of Permixon on dihydrotestosterone and testosterone binding by eleven different tissue specimens was tested. The drug reduced the mean uptake of both hormones by 40.9% and 41.9% respectively in all tissue specimens. Since hirsutism and virilism are among other gynecological problems caused either by excessive androgen stimulation or excess endorgan response, we suggest that Permixon could be a useful treatment in such conditions and recommend further investigations of the possible therapeutic values of the drug in gynecological practice.
el-Sheikh
M M
MM
Department of Obstetrics and Gynaecology, King Khalid University Hospital, Riyadh, Saudi Arabia.
Dakkak
M R
MR
Saddique
A
A
D000328:Adult; D000726:Androgen Antagonists / Q000494:pharmacology*; D013196:Dihydrotestosterone / Q000378:metabolism; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011944:Receptors, Androgen; D011987:Receptors, Steroid / Q000187:drug effects*; D028024:Serenoa; D014018:Tissue Distribution
D000726:Androgen Antagonists; D010936:Plant Extracts; D011944:Receptors, Androgen; D011987:Receptors, Steroid; D013196:Dihydrotestosterone; C040972:saw palmetto extract