title: [The antibacterial effect of ciprofloxacin, ofloxacin and norfloxacin in vitro].
abstract: MICs of ciprofloxacin (CIP), ofloxacin (OFL) and norfloxacin (NOR) were assessed with a total of 523 strains of 7 species (spp) of enterobacteriaceae, various pseudomonads, methicillin-susceptible and -resistant S. aureus, L. monocytogenes, Legionella species and C. difficile. In addition, the MBCs were assessed with S. aureus and E. coli. With break-points of less than or equal to 0.5 and greater than or equal to 4 mg/l all strains of E. coli, K. oxytoca, P. mirabilis and indole-positive Proteus spp. were susceptible to all 3 antibiotics. Proportions of susceptible strains almost as high were found with E. cloacae, S. marcescens, K. pneumoniae and methicillin-susceptible staphylococci. With Legionella spp. the MICs of CIP and OFL always indicated susceptibility, whereas with NOR only 62% of the strains were inhibited. Pseudomonads, especially others than P. aeruginosa, were only moderately susceptible to CIP and OFL, but never to NOR. Listeria monocytogenes was susceptible to OFL in 96%, to CIP in 56%, but never to NOR. C. difficile was always resistant. The MBC-values either equalled the MICs or surpassed them up to 2 times at maximum indicating a bactericidal mode of action. Despite of slightly lower MICs of CIP in vitro, OFL seems to be comparably effective. NOR is regarded less effective.
authors.affiliation: Hygiene-Institut der Universität Wien.
authors.forename: M
authors.initials: M
authors.lastname: Rotter
authors.forename: A M
authors.initials: AM
authors.lastname: Hirschl
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D002939:Ciprofloxacin / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000494:pharmacology*; D015242:Ofloxacin / Q000494:pharmacology*
chemical_list: D002939:Ciprofloxacin; D015242:Ofloxacin; D009643:Norfloxacin
vernacular_title: Untersuchungen zur antibakteriellen Wirkung von Ciprofloxacin, Ofloxacin und Norfloxacin in vitro.