title: Therapeutic doses of codeine have no effect on acetaminophen clearance or metabolism.
abstract: In nine healthy volunteers, the clearance and metabolism of acetaminophen 1000 mg i.v. was evaluated with and without two concomitant oral doses of codeine in order to investigate a possible interaction. Plasma acetaminophen was followed for 720 min and urine was collected for 24 h after each dose for determination of metabolites. When codeine was coadministered, the average total clearance of acetaminophen and its clearance by glucuronidation, sulphation and mercapturate formation were 0.58 to 1.12-times the control values. It is concluded that therapeutic doses of codeine do not influence the clearance or metabolism of acetaminophen.
authors.affiliation: Department of Medicine F, Gentofte University Hospital, Copenhagen, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Sonne
authors.forename: H E
authors.initials: HE
authors.lastname: Poulsen
authors.forename: S
authors.initials: S
authors.lastname: Loft
authors.forename: M
authors.initials: M
authors.lastname: Døssing
authors.forename: A
authors.initials: A
authors.lastname: Vollmer-Larsen
authors.forename: K
authors.initials: K
authors.lastname: Simonsen
authors.forename: H
authors.initials: H
authors.lastname: Thyssen
authors.forename: K
authors.initials: K
authors.lastname: Lundstrøm
mesh_terms: D000082:Acetaminophen / Q000378:metabolism / Q000493:pharmacokinetics*; D000328:Adult; D003061:Codeine / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male
chemical_list: D000082:Acetaminophen; D003061:Codeine