[Pharmacological studies on Y-8894. (VIII). Effects on learning and memory in the radial maze task in mice].
Effects of Y-8894 on learning and memory were studied using a radial maze task in intact and scopolamine-induced amnesic mice. The following results were obtained: 1) Repeated administration of Y-8894 (1, 2.5 and 5 mg/kg, i.p.) significantly increased the number of initial correct responses (ICR) in the training session in intact mice, facilitating the learning of the maze task. Dihydroergotoxine (5 mg/kg, i.p.) significantly facilitated the learning of this task in the initial stage of the training session, but non-specifically inhibited the performance in the late stage of training. Ca-hopantenate did not modify the learning of this task. 2) A single administration of Y-8894 (2.5 or 5 mg/kg, i.p.) showed an antagonistic effect on scopolamine (1 mg/kg, s.c.)-induced amnesic mice. Dihydroergotoxine (5 mg/kg, i.p.) and Ca-hopantenate (500 mg/kg, i.p.) also significantly antagonized the ICR-decreasing effect of scopolamine. These results suggest that Y-8894 has an ameliorative and/or facilitative effect on learning and memory in the radial maze task, and Y-8894 is more potent than dihydroergotoxine and Ca-hopantenate.
Anami
K
K
Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd., Fukuoka, Japan.
Setoguchi
M
M
Senoh
H
H
D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy / Q000523:psychology*; D000818:Animals; D004088:Dihydroergotoxine / Q000494:pharmacology; D007858:Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D051379:Mice; D009025:Morpholines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010205:Pantothenic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D012601:Scopolamine; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology
D009025:Morpholines; D004088:Dihydroergotoxine; C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid; C045330:sufoxazine; D012601:Scopolamine