[Spectral manifestations of the effect of Zn2+ ions on DNA complexes with distmycin].
Effect of low concentrations of metal bivalent ions on DNA-distamycin complexes was studied. It has been found that when adding small quantity of Zn2- ions the DNA-distamycin complex changes its cooperative properties. A small amount of heavy metal ions incorporated in DNA changes the DNA property to form complexes capable of stimulating the formation of structures of high organization. Thus under the effect of metal small additions both the structure of cellular processes and their regulation are irreversibly simplified, the phase of rest characterized by the maximal number of organization levels of the nuclear apparatus not being reached.
Andronikashvili
E L
EL
Esipova
N G
NG
Kharatishvili
M G
MG
D000818:Animals; D002417:Cattle; D002942:Circular Dichroism; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D004214:Distamycins / Q000378:metabolism*; D066298:In Vitro Techniques; D007477:Ions; D011758:Pyrroles / Q000378:metabolism*; D015032:Zinc / Q000494:pharmacology*
D004214:Distamycins; D007477:Ions; D011758:Pyrroles; D004247:DNA; D015032:Zinc
Spektral'nye proiavleniia deĭstviia ionov Zn2+ na kompleksy DNK s distamitsinom.