title: Spontaneous hepatitis in Long-Evans rats. A potential animal model for fulminant hepatitis in man.
abstract: Spontaneous hepatitis associated with severe jaundice occurred in 90% of an inbred strain of Long-Evans rats. The rapidly progressive syndrome was characterized by abrupt onset, hyperbilirubinemia and increased serum levels of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase, associated with massive and multifocal necrosis of the liver. This strain should provide a useful animal model for analysis of the pathogenesis of fulminant hepatitis in humans.
authors.affiliation: Laboratory of Pathology, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Takeichi
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: M C
authors.initials: MC
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Dempo
authors.forename: M
authors.initials: M
authors.lastname: Mori
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood / Q000652:urine; D004195:Disease Models, Animal / Q000473:pathology*; D005260:Female; D006427:Hemin / Q000652:urine; D006505:Hepatitis / Q000097:blood / Q000473:pathology* / Q000652:urine; D006520:Hepatitis, Animal / Q000097:blood / Q000473:pathology* / Q000652:urine; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006427:Hemin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin