Reflex responses of vascular resistance in anaesthetized dogs to independent changes in ventricular systolic pressure and cardiac inotropic state.
Responses of systemic arterial perfusion pressure to changes in ventricular systolic pressure were determined before and after administration of dobutamine, then after propranolol, to determine whether the effective stimulus to left ventricular receptors was the change in ventricular systolic pressure or inotropic state. The results showed that increases in ventricular systolic pressure resulted in reflex vasodilatation which was unaffected by inotropic state, indicating that changes in ventricular systolic pressure provided the more potent stimulus.
Tutt
S M
SM
Department of Cardiovascular Studies, University of Leeds.
Al-Timman
J K
JK
Hainsworth
R
R
D000818:Animals; D004280:Dobutamine / Q000494:pharmacology; D004285:Dogs; D006352:Heart Ventricles / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology; D012016:Reference Values; D012018:Reflex / Q000187:drug effects; D013599:Systole / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D016276:Ventricular Function
D004280:Dobutamine; D011433:Propranolol