Acute radiation nephritis. Its evolution on sequential bone imaging.
Acute radiation nephritis typically affects the kidneys 3-12 months after radiation exposure and may occur with doses as low as 2500 rads. After an initial latent period, the affected portions of the kidneys become swollen and edematous, and develop multiple petechiae. Necrotizing vasculitis and interstitial hemorrhage occur, and the end stage is that of scarring. Two patients are presented in whom localized acute radiation nephritis developed, and whose kidneys demonstrated the characteristic sequential changes of this entity on serial bone imaging.
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Andre Meyer Department of Physics-Nuclear Medicine, Mt. Sinai School of Medicine, Sinai Medical Center, New York, New York 10029.
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Goldsmith
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D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000532:radiotherapy / Q000556:secondary; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D001943:Breast Neoplasms; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000528:radiation effects; D008297:Male; D009393:Nephritis / Q000000981:diagnostic imaging* / Q000209:etiology; D011832:Radiation Injuries / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D011879:Radiotherapy Dosage; D012512:Sarcoma, Ewing / Q000532:radiotherapy