Specific antibody containing cells in the porcine respiratory tract following intraperitoneal and intratracheal immunisation.
Pigs were immunised intraperitoneally with ovalbumin in Freund's complete adjuvant and subsequently challenged intratracheally with ovalbumin. The results show that the group receiving two intratracheal challenges had a significantly greater antiovalbumin-containing cell response in the lamina propria of the respiratory tract. With intraperitoneal immunisation or intratracheal challenge alone the response was negligible. The immunoglobulin isotype of the anti-ovalbumin containing cells was predominantly IgG. There was also a substantial antibody containing cell response in the lung which was also IgG. These findings are discussed in relation to immunity within the porcine respiratory tract.
Sheldrake
R F
RF
New South Wales Agriculture and Fisheries, Veterinary Laboratories, Glenfield, Australia.
Romalis
L F
LF
Saunders
M
M
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology*; D007114:Immunization / Q000662:veterinary*; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D008168:Lung / Q000166:cytology / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D010047:Ovalbumin / Q000276:immunology; D010537:Peritoneum / Q000276:immunology; D013552:Swine / Q000276:immunology*; D014132:Trachea / Q000166:cytology / Q000276:immunology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D010047:Ovalbumin