[Contribution of animal experiments in the problem of a long-term indomethacin therapy in advanced nephron loss].
Residual nephrons are subject to compensatory adaptation at which the glomerular hyperfiltration and convection of macromolecules (proteins) are of pathogenic character in the progression of nephropathy. The influence of indomethacin at dosages of 2 or 3 mg/kg body weight/day was investigated in long-term feeding trials (8 months) on inbred female Wistar rats after unilateral nephrectomy and additional resection of both kidney poles. The results show a significant deterioration of vital prognosis under indomethacin medication independently of the dosage.
Hortian
B
B
Abteilung Pathophysiologie, Wilhelm-Pieck-Universität Rostock.
Wüstenberg
P W
PW
Klinkmann
H
H
Schröder
J
J
Schumann
L
L
D000818:Animals; D005260:Female; D005919:Glomerular Filtration Rate; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000150:complications*; D051379:Mice; D009392:Nephrectomy; D009399:Nephrons / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D007213:Indomethacin
Tierexperimenteller Beitrag zur Frage der Indometacin-Langzeittherapie bei fortgeschrittenem Nephronverlust.