Effect of ba-wei-di-huang-wan (hachimi-jio-gan) on thymidine kinase and its isozyme activities in the prostate glands in rats.
Ba-wei-di-huang-wan (Hachimi-jio-gan, TJ-7) has been frequently used for the treatment of sterilitas virilis, prostatic disorders, etc. The hormonal effects of TJ-7 were studied using thymidine kinase (TK), an enzyme that catalyzes the phosphorylation of thymidine via the pyrimidine salvage pathway. TK isozyme activity increases in rapidly proliferating tissues. TJ-7 may act as a weak androgen and enhance prostatic TK and in particular, a specific TK isozyme activity, and also as an anti-androgen and reduce prostatic TK activity in the presence of androgen in immature rats.
Sakamoto
S
S
Department of Endocrinology, Tokyo Medical and Dental University, Japan.
Kudo
H
H
Kawasaki
T
T
Kasahara
N
N
Okamoto
R
R
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D011467:Prostate / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013937:Thymidine Kinase / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D007527:Isoenzymes; C054591:hachimijiogan; D013937:Thymidine Kinase