[Electrical activity of the heart cells and myocardial contractility during a change in extracellular sodium concentration].
The transmembrane potentials of the cells of the ventricle contractile myocardium of the rat and frog isolated hearts were studied as well as the strength of the ventricle contraction under the effect of a decrease (to 30 mM) or increase (up to 200 mM) in the sodium chloride concentration in the perfusate. The decrease led to a fibrillation of ventricles, 80-85% of contractile cells generating a high-frequency activity, 12-15% preserving the same AP and 3-5% having completely lost the excitability. The increase only affects the transmembrane potentials of ischemized myocardium. The decrease in the sodium concentration led to an augmentation of the contraction strength through the sodium-calcium exchange mechanism.
Kobrin
V I
VI
Alabovskiĭ
V V
VV
Alipov
N N
NN
Oleĭnikov
O D
OD
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003327:Coronary Disease / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005110:Extracellular Space / Q000187:drug effects / Q000502:physiology*; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000166:cytology*; D010477:Perfusion / Q000379:methods; D011898:Ranidae; D051381:Rats; D012964:Sodium / Q000502:physiology*; D012965:Sodium Chloride / Q000494:pharmacology
D012965:Sodium Chloride; D012964:Sodium
Elektricheskaia aktivnost' kletok serdtsa i sokratimost' miokarda pri izmenenii vnekletochnoĭ kontsentratsii natriia.