Erythema multiforme is associated to HLA-Aw33 and DRw53.
Erythema multiforme is an acute eruption of the skin and mucous membranes of various aetiologies. Forty-one unrelated patients were HLA typed for 53 specificities of the HLA-A, B, C, DR and DQ series. Frequencies of Aw33 and DRw53 were significantly increased: Aw33, 17.0% in patients vs 2.8% in controls (corrected p = 0.01, relative risk = 7.2); DRw53, 70.7% in patients vs 30.5% in controls (corrected p = 0.0005, relative risk = 5.5).
Lepage
V
V
Laboratoire d'Immunologie et d'Histocompatibilité, Hôpital Saint Louis, France.
Douay
C
C
Mallet
C
C
Binet
O
O
Lemarchand
F
F
Wallach
D
D
Masset
M
M
Colombani
J
J
Degos
L
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004892:Erythema Multiforme / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D059845:HLA-DRB4 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype
D015234:HLA-A Antigens; C082945:HLA-A*33 antigen; D006684:HLA-DR Antigens; C050610:HLA-DR53; D059845:HLA-DRB4 Chains