A device to evoke acetylcholine release electrically in the guinea pig myenteric plexus/longitudinal muscle preparation through mass electrodes.
A stimulator was developed to evoke acetylcholine release in the myenteric plexus-longitudinal muscle preparation from the guinea pig ileum. A power output stage was devised to allow a conventional stimulator to drive the low impedance presented by this type of preparation. To eliminate electrode polarization, the polarity of the stimulus is alternated. A peak reading ammeter is included which allows the investigator to monitor the stimulus.
Silverman
R W
RW
Department of Pharmacology, School of Medicine, University of California, Los Angeles.
Jenden
D J
DJ
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D004558:Electric Stimulation / Q000295:instrumentation*; D004566:Electrodes; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009132:Muscles / Q000378:metabolism / Q000502:physiology*; D009197:Myenteric Plexus / Q000378:metabolism / Q000502:physiology*
D000109:Acetylcholine