title: Nd:YAG laser-induced hyperthermia in a mouse tumor model.
abstract: Hyperthermic tumor response induced by 1,064-nm radiation from an Nd:YAG laser was investigated in DBA/2J female mice bearing the SMT-F mammary carcinoma. The measured temperature-depth profiles indicate that hyperthermic temperatures can be achieved in tumors ranging from 3 to 8 mm thick at power inputs on the order of 1 W. For small tumors, a 5-week complete response rate exceeding 50% required 45 minutes at 45.0 degrees C. Control of large tumors (6-8 mm thick) was not achieved. The observed tumor response rates are consistent with semiempirical time-temperature relations based on other heating modalities.
authors.affiliation: Wenske Laser Center, Ravenswood Hospital Medical Center, Chicago.
authors.forename: S M
authors.initials: SM
authors.lastname: Waldow
authors.forename: P R
authors.initials: PR
authors.lastname: Morrison
authors.forename: L I
authors.initials: LI
authors.lastname: Grossweiner
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000628:therapy*; D003131:Combined Modality Therapy; D006979:Hyperthermia, Induced / Q000379:methods*; D053685:Laser Therapy; D008325:Mammary Neoplasms, Experimental / Q000628:therapy*; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D010778:Photochemotherapy; D013817:Thermography