title: Uterine and cytoplasmic effects on pup eyelid opening in two inbred strains of mice.
abstract: Age at Eyelid Opening (AEO) differs in two inbred strains of laboratory mice: NZB and CBA/H. Ovarian transplantation and fostering methods were employed to test for variation of genotypic expression in different environments. (1) A global maternal effect was demonstrated for AEO in parental and F1 pups. (2) AEO of H and N pups is not affected by the parental vs. F1 modification of post-natal maternal environment. (3) The genotype of the mother, via uterine environment, interacts with pup genotype: only the CBA/H strain reacts to the parental vs. F1 modification in uterine environment. (4) A cytoplasmic effect for AEO was successfully replicated. Additional analyses demonstrate that AEO is not cytoplasmically inherited but rather modulated by the cytoplasmic environment.
authors.affiliation: Génétique, Neurogénétique et comportements, UA 656 au C.N.R.S. UER Biomedicale de Paris V, France.
authors.forename: M
authors.initials: M
authors.lastname: Nosten
authors.forename: P
authors.initials: P
authors.lastname: Roubertoux
mesh_terms: D000375:Aging; D000818:Animals; D005143:Eyelids / Q000254:growth & development / Q000502:physiology*; D005260:Female; D008431:Maternal-Fetal Exchange; D051379:Mice; D008808:Mice, Inbred CBA / Q000254:growth & development; D008815:Mice, Inbred Strains / Q000254:growth & development*; D011247:Pregnancy; D013045:Species Specificity; D014599:Uterus / Q000502:physiology*