Chemical stabilities of famotidine and ranitidine hydrochloride in intravenous admixtures.
The chemical stabilities of famotidine and ranitidine hydrochloride solutions in 5% dextrose and 0.9% sodium chloride injections have been studied using high-performance liquid chromatographic methods (HPLC). Both the drugs were stable for at least 15 days (loss in potency of less than 10%) at 25 degrees C and 63 days at 5 degrees C. Both drugs were comparatively less stable in 5% dextrose injection than in 0.9% sodium chloride injection. The loss in the potency of phenol, which is added as a preservative to ranitidine hydrochloride injection, was significant in both the vehicles. However, the addition of preservative in a single dose vial is not considered necessary.
Das Gupta
V
V
Department of Pharmaceutics, University of Houston, TX 77030.
Parasrampuria
J
J
Bethea
C
C
D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D004356:Drug Storage / Q000379:methods; D015738:Famotidine; D005947:Glucose; D007275:Injections, Intravenous; D011899:Ranitidine / Q000032:analysis; D012965:Sodium Chloride; D012996:Solutions; D013696:Temperature; D013844:Thiazoles / Q000032:analysis
D012996:Solutions; D013844:Thiazoles; D012965:Sodium Chloride; D015738:Famotidine; D011899:Ranitidine; D005947:Glucose