Conformational modification of the PRP-hexapeptide by a direct covalent attachment of aromatic side chain groups.
PRP-hexapeptide possessing the azo-bridge between Tyr1 and Phe5 residues, called azo-PRP-hexapeptide: (formula; see text), was synthesized and tested for immunoregulatory activity. High biological activity of the synthesized azo-PRP-hexapeptide suggests that the biologically active conformation of PRP-hexapeptide must be such that both aromatic rings (Tyr and Phe) are apparently close to each other.
Szewczuk
Z
Z
Institute of Chemistry, University of Wroclaw, Poland.
Kubik
A
A
Siemion
I Z
IZ
Wieczorek
Z
Z
Spiegel
K
K
Zimecki
M
M
Janusz
M
M
Lisowski
J
J
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis*; D000818:Animals; D000917:Antibody Formation; D007202:Indicators and Reagents; D051379:Mice; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000276:immunology; D009904:Optical Rotation
D000276:Adjuvants, Immunologic; D007202:Indicators and Reagents; D009842:Oligopeptides; C058579:proline-rich polypeptide, C-terminal hexapeptide