Synthesis and pharmacological properties of decahydro-5H-pyrido [1',2';5,1] imidazo [3,4-a]-beta-carbolines. Part II.
Ten cyclic animals (1-10), including a form of decahydro-5H-pyrido [1',2';5,1] imidazo [3,4-a]-beta-carboline, were obtained by treating erythro 1-(2'-piperidyl)-1,2,3,4-tetrahydro-beta-carboline with aldehydes. The anticonvulsant action of those compounds (1-10) was investigated in mice using a behavioral test. Only 5-(3-chlorophenyl) (2) and 5-(3-pyridyl) (9) derivatives showed an anticonvulsant activity in the electric seizure test, but their therapeutic index was inferior to that of phenytoin.
Misztal
S
S
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Dukat
M
M
Chojnacka-Wójcik
E
E
Tatarczyńska
E
E
D000818:Animals; D000927:Anticonvulsants; D002243:Carbolines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole; D010672:Phenytoin / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D012640:Seizures / Q000209:etiology / Q000517:prevention & control; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D002243:Carbolines; D007093:Imidazoles; D011725:Pyridines; D010672:Phenytoin; D010433:Pentylenetetrazole