title: Comparison of autoantibodies level in thyroid autoimmune diseases estimated by different methods.
abstract: Autoantibodies to different thyroid cell components in serum of patients with thyroid disease have been estimated by several methods. The TSH receptor antibodies (TRAb) have been detected in 77% of untreated Graves-Basedow, in 70% of thionamide drugs treated Graves-Basedow patients up to four months of the treatment and in 48% of patients with Hashimoto's thyroiditis. Microsomal antibodies (MAb) and thyroid plasma membrane antibodies (ATMA) have been detected in 84% and 68% respectively, in thionamide drugs treated Graves-Basedow and in 91% and 72% in Hashimoto's thyroiditis. The thyroglobulin antibodies have been detected in 42% of untreated Graves-Basedow, in 47% of thionamide drugs treated Graves-Basedow and in 77% of Hashimoto's thyroiditis. In 19% to 21% of patients with toxic nodular goiter underlying autoimmunological process have been established by the detection of high levels of serum autoantibodies (ATMA and MAb). In the non-toxic nodular goiter, non-thyroid autoimmune diseases and healthy blood donors only thyroglobulin antibodies were detected in a significant number of patients. Other types of antibodies (ATMA or MAb) were detected only in sporadic cases of non-thyroid autoimmune diseases.
authors.affiliation: Medical Center of Postgraduate Education, Biochemistry Department, Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Gardas
authors.forename: A
authors.initials: A
authors.lastname: Blottner
authors.forename: H
authors.initials: H
authors.lastname: Domek
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology*; D003937:Diagnosis, Differential; D003955:Diagnostic Tests, Routine / Q000379:methods; D006111:Graves Disease / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D013959:Thyroid Diseases / Q000175:diagnosis / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis / Q000276:immunology*
chemical_list: D001323:Autoantibodies