Pigmentation of glucocorticoid-induced cataractous lenses of developing chick embryos on heating.
Cataractous lenses produced by hydrocortisone or prednisolone treatment in developing chick embryos turned golden brown on heating at 100 degrees C for 60 min. Analysis of an 80% ethanol fraction from the lenses, which contained the pigment-forming substance(s), demonstrated that the heat-induced pigmentation was related to the appearance of opacity of the lens after glucocorticoid administration and suggested that the pigmentation occurred by the Maillard reaction between glucose and amino acids.
Nishigori
H
H
Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
Iwatsuru
M
M
Hikida
M
M
D000818:Animals; D002386:Cataract / Q000175:diagnosis*; D002642:Chick Embryo; D003348:Cortisone; D003350:Cortodoxone; D006358:Hot Temperature; D006854:Hydrocortisone; D007908:Lens, Crystalline / Q000378:metabolism; D010858:Pigmentation; D011239:Prednisolone; D013997:Time Factors
D011239:Prednisolone; D003348:Cortisone; D003350:Cortodoxone; D006854:Hydrocortisone