The effect of low protein-high dextrin diet and subsequent food restriction upon life prolongation in Fischer 344 male rats.
Fischer 344 rats fed low protein-high dextrin diet exhibit a higher median (but not 10th percentile) survival as compared to controls. The effect of this diet appears already if the diet is administered between 6 weeks and 6 months of age; after this treatment median survival of experimental animals is increased by 96 days while the 10th percentile is not different from standard diet-fed controls. Further treatment of animals with the same diet has minimum effect as animals that lived on this regimen throughout the whole life exhibited a median lifespan increase by 120 days and increase in the 10th percentile by 41 days. However, if such animals at the age of 6 months are transferred to a restricted (60%) food intake regimen (control diet, not carbohydrate enriched) a further increase in median and 10th percentile lifespan prolongation can be observed reaching +328 and +396 days respectively as compared to controls. The effects of this early feeding (6 weeks to 6 months) with a low protein-high carbohydrate diet available ad libitum and the food restricted regimen (standard diet 60% controls) fed from the age 6 months onwards are additive, the final results being identical to those obtained if the animals were kept on the 60% food restricted intake throughout the whole life. The fact that animals fed the low protein-high carbohydrate diet and those kept on 60% standard diet food restriction had different survival though they were equal in daily (identical) protein intake is emphasized.
Horáková
M
M
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
Deyl
Z
Z
Hausmann
J
J
Macek
K
K
D000818:Animals; D003912:Dextrins / Q000494:pharmacology*; D004044:Dietary Proteins / Q000008:administration & dosage*; D005508:Food Deprivation; D008017:Life Expectancy; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013213:Starch / Q000494:pharmacology*
D003912:Dextrins; D004044:Dietary Proteins; D013213:Starch