title: Liposome-bound cyclosporine: clearance after intravitreal injection.
abstract: The concentration of cyclosporine in the vitreous after intravitreal injection of 100 micrograms of either free or liposome-bound cyclosporine was studied in albino rabbits. We found that the half-life of free cyclosporine was about 6 hours and that of liposome-bound cyclosporine was about 3 days. The finding indicates that liposome-bound cyclosporine prolongs the availability of the drug.
authors.affiliation: LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans.
authors.forename: A A
authors.initials: AA
authors.lastname: Alghadyan
authors.forename: G A
authors.initials: GA
authors.lastname: Peyman
authors.forename: B
authors.initials: B
authors.lastname: Khoobehi
authors.forename: S
authors.initials: S
authors.lastname: Milner
authors.forename: K R
authors.initials: KR
authors.lastname: Liu
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003524:Cyclosporins / Q000008:administration & dosage / Q000493:pharmacokinetics; D004337:Drug Carriers; D007267:Injections; D008081:Liposomes; D011817:Rabbits; D013997:Time Factors; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D003524:Cyclosporins; D004337:Drug Carriers; D008081:Liposomes