title: Prevention of IOP-rise following Nd-YAG laser capsulotomy with topical timolol and indomethacin.
abstract: Short term observation following Nd-YAG laser capsulotomy indicates that serious elevation of intra-ocular pressure may occur, unrelated to the amount of incident energy used. In this study we evaluated the effect of pre-treatment with anti-prostaglandin eyedrops on the rise in IOP. The IOP in forty pseudophakic patients, undergoing Nd-YAG laser posterior capsulotomy, was measured before capsulotomy and 2 and 4 hours afterwards. The fellow-eye was used as a control. Thirty minutes pre-operatively the patients were given one of the four following combinations of eyedrops: 1 drop timolol 0.5% and 1 drop placebo, 1 drop indomethacin 1% and 1 drop placebo, 1 drop timolol 0.5% and 1 drop indomethacin 1%, 1 drop placebo and 1 drop placebo. Statistical analysis of the results showed that indomethacin alone has little influence on the IOP-rise, whereas timolol has. When indomethacin is added to timolol there is no significant enhancement.
authors.affiliation: Department of Ophthalmology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Van der Feltz van der Sloot
authors.forename: J S
authors.initials: JS
authors.lastname: Stilma
authors.forename: T N
authors.initials: TN
authors.lastname: Boen-Tan
authors.forename: P D
authors.initials: PD
authors.lastname: Bezemer
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D053685:Laser Therapy; D007903:Lens Capsule, Crystalline / Q000601:surgery*; D007908:Lens, Crystalline / Q000601:surgery*; D007910:Lenses, Intraocular; D008875:Middle Aged; D009798:Ocular Hypertension / Q000517:prevention & control*; D010919:Placebos; D013999:Timolol / Q000627:therapeutic use*; D014065:Tonometry, Ocular; D014792:Visual Acuity
chemical_list: D010919:Placebos; D013999:Timolol; D007213:Indomethacin