[Problems of pathogenesis of ovarian and idiopathic hirsutism].
The content of total testosterone (T), dehydrotestosterone (DHT), androstenedione (A), estradiol (E2), luteotropin (LH) and follicle-stimulating hormone (FSH) was studied in patients with ovarian and idiopathic hirsutism by a radioimmunoassay. The level of T-E-binding globulin (TEBG) was determined by 3H-DHT binding. Concentrations of free and TEBG-unbound T, DHT and E2 were calculated on the basis of the mass action law. The level of free and TEBG-unbound T and DHT was found to be the most reliable marker of the excessive production of androgens in hirsutism. The level of total T and DHT was raised in 50-60% of patients with hirsutism. Patients with hirsutism of ovarian genesis were characterized by considerable blood elevation of LH and FSH with still greater values in patients with menstrual disturbance, and by a rise of an A level. Difference found in hormonal indices can be used in differential diagnosis of ovarian and idiopathic hirsutism.
Tarasenko
L V
LV
Reznikov
A G
AG
Benikova
E A
EA
Varga
S V
SV
Derevianko
D I
DI
D000293:Adolescent; D000328:Adult; D005260:Female; D006628:Hirsutism / Q000097:blood / Q000209:etiology*; D006728:Hormones / Q000097:blood; D006801:Humans; D010049:Ovarian Diseases / Q000150:complications*
D006728:Hormones
Voprosy patogeneza ovarial'nogo i idiopaticheskogo girsutizma.