Chromosomal distribution of the RTVL-H family of human endogenous retrovirus-like sequences.
We have analyzed the chromosomal distribution of a large family of human endogenous retrovirus-like sequences termed RTVL-H. In situ hybridizations suggest that these sequences are found on all human chromosomes. These results also indicate that clusters or concentrations of RTVL-H elements may exist on chromosomes 1p and 7q. Southern blotting experiments using somatic cell hybrids containing either the human chromosome 3 or the X chromosome confirm the presence of multiple dispersed RTVL-H sequences on these two chromosomes. These experiments also demonstrate that distinct RTVL-H banding patterns can be detected for each chromosome. Thus, RTVL-H probes may be useful in genome mapping studies.
Fraser
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Terry Fox Laboratory, B.C. Cancer Research Centre, Vancouver, Canada.
Humphries
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Mager
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D000818:Animals; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D002895:Chromosomes, Human, Pair 5; D002897:Chromosomes, Human, Pair 7; D006224:Cricetinae; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D006822:Hybrid Cells / Q000166:cytology; D009693:Nucleic Acid Hybridization; D012190:Retroviridae / Q000235:genetics*
D004279:DNA, Viral