title: Endogenous lectin CSL is present on the membrane of cilia of rat brain ependymal cells.
abstract: An endogenous brain lectin, with a great affinity for oligomannosidic glycans, called CSL (for 'cerebellar soluble lectin'), was detected on the surface of the cilia of ependymal cells both in cultures and in vivo. The lectin is not synthesized by the ependymal cells themselves. In vivo it is neither found in cerebrospinal fluid nor in cells of the choroid plexus. Probably, lectin CSL is produced by subependymal astrocytic cells. The membranes of ependymal cells seem to possess glycoprotein ligands for the lectin which explain the specific adhesion of CSL on the surface of these cells, particularly on the cilia. The localization of this adhesive molecule on cilia of ependymal cells suggests that it may play a role in trapping foreign cells, micro-organisms or debris.
authors.affiliation: Centre de Neurochimie du CNRS, Strasbourg.
authors.forename: F
authors.initials: F
authors.lastname: Perraud
authors.forename: S
authors.initials: S
authors.lastname: Kuchler
authors.forename: S
authors.initials: S
authors.lastname: Gobaille
authors.forename: G
authors.initials: G
authors.lastname: Labourdette
authors.forename: G
authors.initials: G
authors.lastname: Vincendon
authors.forename: J P
authors.initials: JP
authors.lastname: Zanetta
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology; D001923:Brain Chemistry; D002478:Cells, Cultured; D002923:Cilia / Q000032:analysis; D004591:Electrophoresis, Polyacrylamide Gel; D004805:Ependyma / Q000032:analysis* / Q000166:cytology; D015151:Immunoblotting; D007150:Immunohistochemistry; D037102:Lectins / Q000032:analysis*; D008565:Membrane Proteins / Q000032:analysis*; D051381:Rats
chemical_list: D037102:Lectins; D008565:Membrane Proteins