[Effect of strychnine on the neuronal reactivity of the sensorimotor cortex and the temporary connection in rabbits].
On awake nonimmobilized rabbits, evoked activity was studied of the sensorimotor cortex neurons in response to stimulation of the pyramidal tract, medial lemniscus and reticular nucleus of the midbrain tegmentum by stimuli of different frequencies, and driving reaction of cortical neurons to stimulation of these brain structures by series of stimuli of increasing frequency. Conditioned reflexes were also studied, established on the basis of combination of direct stimulation of the sensorimotor cortex and electrocutaneous stimulation. Application of the cortex of low concentration of strychnine solutions (less than 1%) heightened neurons reactivity and provides for the formation of temporary connection. Application of strychnine solutions of higher concentration (greater than 1%) led to opposite effects. Interconnection of electrical and behavioural effects is discussed.
Chizhenkova
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RA
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation / Q000379:methods; D005071:Evoked Potentials / Q000187:drug effects; D008297:Male; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D013268:Stimulation, Chemical; D013331:Strychnine / Q000494:pharmacology*; D013997:Time Factors
D013331:Strychnine
Vliianie strikhnina na reaktivnost' neĭronov sensomotornoĭ kory i vremennuiu sviaz' u krolikov.