Pain after spinal intrathecal clonidine. An adverse interaction with tricyclic antidepressants?
A case is reported in which spinal intrathecal administration of clonidine produced pain. The interaction between clonidine and tricyclic antidepressants is discussed, and is suggested as the basis for this observation.
Hardy
P A
PA
Centre for Pain Relief, Walton Hospital, Liverpool.
Wells
J C
JC
D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage* / Q000009:adverse effects; D003000:Clonidine / Q000009:adverse effects*; D004347:Drug Interactions; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D010146:Pain / Q000139:chemically induced*
D000929:Antidepressive Agents, Tricyclic; D003000:Clonidine