[Changes in the functional parameters of the brain structures under the influence of enkephalin-like tetrapeptidamide].
In complex neurophysiological and cytobiochemical study single injections of tetrapeptide amide (TPA) caused a short-term analgetic effect which manifested itself in the absence of motor reactions and EEG changes of cortical and subcortical brain structures after painful stimulation of extremities. This effect was accompanied by changes of some indices of transmitter (monoamine oxidase) and protein metabolism in the cerebral hemispheres at cellular and subcellular levels. In 30-40 min after a TPA injection, EEG suppression and absence of EPs to light flashes were observed in cortical and subcortical structures. Simultaneously motor disorders developed. The observed EEG changes had an undulatory character: on the second day EEGs were restored and on the third day--suppressed once again. This period of TPA action was accompanied by varied changes of the investigated types of metabolism. The question of the necessity of systemic approach to the study of TPA action is discussed, as such an approach allows to reveal complex neurophysiological and fine biochemical relations in the reactions of brain structures and in animal behaviour.
Adrianov
O S
OS
Gershteĭn
L M
LM
Popova
N S
NS
Dovedova
E L
EL
D000110:Acetylcholinesterase / Q000378:metabolism; D000626:Aminopeptidases / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D004285:Dogs; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D006651:Histocytochemistry; D008995:Monoamine Oxidase / Q000378:metabolism; D009842:Oligopeptides / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D009842:Oligopeptides; C037379:tyrosyl alanyl-glycyl-phenylalaninamide; D008995:Monoamine Oxidase; D000110:Acetylcholinesterase; D000626:Aminopeptidases
Izmeneniia funktsional'nykh pokazateleĭ struktur mozga pod vliianiem énkefalinopodobnogo tetrapeptidamida.