Hyperfibrinolysis: its express diagnosis and role in the development of haemorrhagic syndrome after cardiopulmonary bypass.
Using a new method of express diagnosis, the authors proved that activation of the fibrinolytic system, which occurs after open-heart operations, can be the cause of excessive hypo coagulation and massive haemorrhage. Partial correction of hyperfibrinolysis, attained by adequate dosage of antifibrinolytic drugs and administered under the control of the proposed diagnostic method, makes possible to attain normalization of haemostatic processes in the operation wound and to avoid intensification of the syndrome of disseminated intravascular coagulation of blood.
Sukhanov
V A
VA
Medical Institute, Sverdiovsk, USSR.
Bauman
N N
NN
Levit
A L
AL
D015119:Aminocaproic Acid / Q000008:administration & dosage; D002315:Cardiopulmonary Bypass; D005342:Fibrinolysis / Q000187:drug effects; D006350:Heart Valve Prosthesis; D006470:Hemorrhage / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D008943:Mitral Valve / Q000601:surgery*; D011183:Postoperative Complications / Q000097:blood* / Q000188:drug therapy; D013577:Syndrome; D014914:Whole Blood Coagulation Time
D015119:Aminocaproic Acid