Chronic granulomatous disease in two Chinese families.
Two Chinese families with X-linked chronic granulomatous disease (CGD) are reported. The first case was an 11-month-old male baby and the second a 2-month-old male baby. Both patients presented with persistent infections caused by Staphylococcus and Candida since birth. Neutrophil functions were studied in patients and a number of family members. Chemotaxis and phagocytosis were normal in every subject. Slide and spectrophotometric nitroblue tetrazolium (NBT) tests of both patients were abnormal and remained unchanged in spite of treatment with ascorbic acid, levamisole, sulfamethoxazole, trimethoprim and isoniazide. Mothers were proved to be carriers as evidenced by the presence of both normal and CGD phagocytes in the slide NBT test. During the 2-month follow-up period, the percentage of normal phagocytes from the mother of case 1 varied from 12% to 73%, which correlated with the fluctuation of spectrophotometric NBT value. The slide NBT test of the mother of case 2 was nearly normal in face of the presence of CGD phagocytes. Both carrier mothers were healthy and asymptomatic.
Lin
Y Z
YZ
Department of Pediatrics, College of Medicine, National Taiwan University Hospital, Taipei, Republic of China.
Hsieh
K H
KH
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001770:Blood Bactericidal Activity; D002681:China; D005260:Female; D005500:Follow-Up Studies; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007223:Infant; D007239:Infections / Q000188:drug therapy / Q000209:etiology; D007538:Isoniazid / Q000494:pharmacology; D008297:Male; D009504:Neutrophils / Q000276:immunology; D009580:Nitroblue Tetrazolium; D010587:Phagocytosis
D000900:Anti-Bacterial Agents; D007136:Immunoglobulins; D009580:Nitroblue Tetrazolium; D007538:Isoniazid