title: Efficacy of ivermectin in paste and injectable formulations against microfilariae of Onchocerca cervicalis and resolution of associated dermatitis in horses.
abstract: The efficacy of a single dose of ivermectin (0.2 mg/kg), in injectable or paste formulations, against microfilariae of Onchocerca cervicalis and associated skin lesions was evaluated in 20 naturally infected horses during midsummer months in Louisiana. All horses had clinical signs of dermatitis of the ventral midline and/or limbs, shoulders, thorax, and withers. Efficacy was monitored at 21, 42, and 63 days after treatment. Procedures done at these intervals included microfilarial counts of 6-mm skin biopsy specimens of affected ventral midline, grading of gross lesions, and photography and histologic assessment of ventral midline biopsy specimens. Microfilarial numbers were reduced to 0 by 21 days after treatment in all but one horse. Active lesions improved or were resolved completely by 63 days after treatment. Total inflammation, as judged by histologic methods, was reduced in all horses by 63 days after treatment, but there was a residual population of inflammatory cells in all horses. Adverse reactions after treatment were not observed in any of the horses.
authors.affiliation: Department of Veterinary Science, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, Baton Rouge 70803-6002.
authors.forename: D D
authors.initials: DD
authors.lastname: French
authors.forename: T M
authors.initials: TM
authors.lastname: Klei
authors.forename: C S
authors.initials: CS
authors.lastname: Foil
authors.forename: R I
authors.initials: RI
authors.lastname: Miller
authors.forename: L D
authors.initials: LD
authors.lastname: Foil
authors.forename: M R
authors.initials: MR
authors.lastname: Chapman
authors.forename: J J
authors.initials: JJ
authors.lastname: McClure
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents; D001706:Biopsy / Q000662:veterinary; D003872:Dermatitis / Q000188:drug therapy / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D006734:Horse Diseases / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D006736:Horses; D007273:Injections, Intramuscular; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D008842:Microfilariae; D009824:Ointments; D009855:Onchocerciasis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D012876:Skin Diseases, Parasitic / Q000473:pathology / Q000662:veterinary*
chemical_list: D000977:Antiparasitic Agents; D009824:Ointments; D007559:Ivermectin