Effect of high-calcium diet on urinary oxalate excretion in urinary stone formers.
The effect of mild high-calcium diet or regular-calcium diet on urinary calcium excretion, urinary oxalate excretion, urinary calcium/creatinine ratio, urinary oxalate/creatinine ratio, and the probability of being a stone former (PSF) were studied in 85 patients with idiopathic urolithiasis. Intake of high-calcium diet for 5-6 days reduced (p less than 0.01-p less than 0.001) urinary oxalate excretion, urinary oxalate/creatine ratio and PSF in patients with idiopathic hypercalciuria. Under the regular-calcium diet, administration of 60 mg/day of pyridoxal phosphate for 3 months lowered (p less than 0.05-p less than 0.01) urinary oxalate excretion, urinary oxalate/creatinine ratio and PSF in patients with idiopathic hypercalciuria alone. From these findings, intake of mild high-calcium diet appears to be beneficial to decrease the urinary oxalate excretion and PSF in patients with idiopathic hypercalciuria. Pyridoxal phosphate has all the features of suppressing such risk factors for stone formation in patients with idiopathic hypercalciuria.
Nakada
T
T
Department of Urology, Chiba University, School of Medicine, Japan.
Sasagawa
I
I
Furuta
H
H
Katayama
T
T
Shimazaki
J
J
D000328:Adult; D000368:Aged; D002118:Calcium / Q000652:urine; D002136:Calcium, Dietary / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006959:Hyperoxaluria / Q000178:diet therapy* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D011732:Pyridoxal Phosphate / Q000627:therapeutic use; D012307:Risk Factors; D014545:Urinary Calculi / Q000178:diet therapy* / Q000517:prevention & control
D002136:Calcium, Dietary; D011732:Pyridoxal Phosphate; D002118:Calcium