title: A case of glucocorticoid-suppressible hyperaldosteronism with aldosterone producing adenoma.
abstract: A 34-yr-old woman with hypertension (142/102 mmHg), hypokalemia, high plasma and urinary aldosterone and low plasma renin activity was studied. A left adrenal tumor and enlarged right adrenal gland were demonstrated by adrenal venography. During administration of dexamethasone (2 mg daily, for 3 weeks), urinary aldosterone excretion decreased abruptly from 22.5 to 9-11 micrograms/day, serum potassium increased and blood pressure fell to 120-130/80-90 mmHg. After left adrenalectomy, all manifestations improved with no medication. The resected adrenal gland revealed clear cell adenoma and micronodular adrenocortical hyperplasia. The patient was considered to be a rare case of glucocorticoid-suppressible hyperaldosteronism with an aldosterone-producing adenoma.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Haji
authors.forename: T
authors.initials: T
authors.lastname: Yanase
authors.forename: H
authors.initials: H
authors.lastname: Nawata
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Ibayashi
mesh_terms: D000236:Adenoma / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D000311:Adrenal Glands / Q000473:pathology; D000328:Adult; D000450:Aldosterone / Q000096:biosynthesis*; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000502:physiology*; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D006965:Hyperplasia / Q000473:pathology; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D005938:Glucocorticoids; D000450:Aldosterone; D003907:Dexamethasone