[The analgesic effect of various fractions of the supernatant of a bone marrow cell culture in pathologic pain].
Different fractions of bone marrow cell culture supernatant effects on pathological pain have been studied. It is shown that all studied fractions have analgesic effect and inhibit strong pain syndrome induced by generator of pathologically enhanced excitation. In distinction from commercial drug myelopid bone marrow supernatant fractions with high and low molecular weight exert analgesic effect in low concentrations not having muscle-relaxant and narcotic influence. It suggests the possibility of creation of some new highly effective analgesic drugs to abolish pain syndromes.
Grafova
V N
VN
Danilova
E I
EI
Zakharova
L A
LA
Mikhaĭlova
A A
AA
D000700:Analgesics / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008297:Male; D008970:Molecular Weight; D009842:Oligopeptides; D010146:Pain / Q000188:drug therapy*; D010455:Peptides / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D013552:Swine
D000700:Analgesics; D009842:Oligopeptides; D010455:Peptides; C048617:myelopeptides
Analgeziruiushchiĭ éffekt razlichnykh fraktsiĭ supernatanta kul'tur kletok kostnogo mozga pri patologicheskoĭ boli.