Vulvar hormonal receptor modifications during topical steroid treatment.
Four groups of 92 patients steroid pre-treated and non-treated vulvar tissues at delivery, during episiotomy, were used in determining androgen, estrogen and progesterone receptors. In 24 central specimens ER and AR concentrations turned out to be quite low when compared to the endometrium and the breast; PgR were much higher in both the cytoplasm and the nucleus, with a statistically significant difference. After estrogen, testosterone and progesterone topical treatment we observed interesting receptor status modifications which emphasize the use of vulvar receptors as marker during local therapy.
Nardelli
G B
GB
Institute of Obstetrics and Gynaecology, University of Padua, Italy.
D000287:Administration, Topical; D001706:Biopsy; D004970:Estrone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage*; D011944:Receptors, Androgen / Q000187:drug effects*; D011960:Receptors, Estrogen / Q000187:drug effects*; D011980:Receptors, Progesterone / Q000187:drug effects*; D013739:Testosterone / Q000008:administration & dosage*; D014844:Vulva / Q000187:drug effects* / Q000473:pathology
D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D004970:Estrone; D013739:Testosterone; D011374:Progesterone