title: [Natural history of synchronous hepatic metastases from a non-treated colorectal cancer].
abstract: The authors present a retrospective study concerning 135 cases of untreated synchronous metastases from colorectal cancer. The median survival is 5.5 months and the natural history is depending on the percentage of liver replacement, on the "performance status" of each patient and on the stage of primary tumors classified according to Dukes. The seric levels of Alkaline Phosphatase and CEA are other useful prognostic factors. The age of patients and systemic chemotherapy (5-Fluorouracil) are not able to influence the evolution of the disease. At last different techniques, both curative and palliative, used in the current treatment of liver metastases from colorectal cancer are discussed and the reported survival improvements reaching with these forms of treatment are compared to the natural history of the disease.
authors.affiliation: Service de Chirurgie Générale, Hôpitaux Réunis de Pesaro, Italie.
authors.forename: R
authors.initials: R
authors.lastname: Giacchi
authors.forename: M
authors.initials: M
authors.lastname: Sebastiani
authors.forename: F
authors.initials: F
authors.lastname: Lungarotti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D003110:Colonic Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012004:Rectal Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor
vernacular_title: Histoire naturelle des métastases hépatiques synchrones dérivées d'un cancer colo-rectal et non traitées.