title: [Value of determining serum enzyme activity during the exercise test in evaluating the functional condition of patients with ischemic heart disease and concomitant diabetes mellitus].
abstract: Exercise-induced changes in the activity of serum lactate dehydrogenase (LDG) and its isoenzymes, CK, aspartate and alanine aminotransferase, were examined in postmyocardial-infarction coronary patients with second-type diabetes mellitus and 18 chronic coronary patients with second-type diabetes mellitus. Patients from both groups showed increased total LDG and LDG-5 activity at rest and reduced total LDG, LDG-1, LDG-2 and LDG-3 activity in response to exercise, which may be an evidence of prevailing anaerobic glycolysis as a manifestation of tissue hypoxia. Rationed bicycle ergometric exercise produces no rise in blood CK, aspartate and alanine aminotransferase activities in coronary patients with second-type diabetes mellitus, suggesting that exercise of this kind has no damaging effect on myocardial and skeletal-muscle myocytes.
authors.forename: L F
authors.initials: LF
authors.lastname: Nikolaeva
authors.forename: A Zh
authors.initials: AZh
authors.lastname: Azhmukhanbetova
authors.forename: V N
authors.initials: VN
authors.lastname: Titov
authors.forename: A A
authors.initials: AA
authors.lastname: Perelygina
mesh_terms: D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D003327:Coronary Disease / Q000150:complications / Q000201:enzymology*; D003402:Creatine Kinase / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000201:enzymology*; D003925:Diabetic Angiopathies / Q000150:complications / Q000201:enzymology*; D004562:Electrocardiography; D005080:Exercise Test; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase
vernacular_title: Znachenie opredeleniia aktivnosti fermentov v syvorotke krovi pri provedenii proby s fizicheskoĭ nagruzkoĭ dlia otsenki funktsional'nogo sostoianiia bol'nykh ishemicheskoĭ bolezn'iu serdtsa s soputstvuiushchim sakharnym diabetom.