title: Ceftizoxime concentrations in human aqueous humor following intravenous administration.
abstract: The aqueous humor penetration of the third-generation cephalosporin, ceftizoxime, was determined in 21 patients awaiting cataract extraction, after an intravenous bolus injection of 2 g. The beta-lactam compound achieved a mean peak aqueous humor concentration of 7.8 mg/l two hours after administration with a serum/humor percent ratio ranging between 7 and 16% during the four-hour sampling interval. Therefore, ceftizoxime levels in this extravascular fluid were above the minimum inhibitory concentrations for the majority of sensitive organisms.
authors.affiliation: USL 18, Div. Oculistica, Ospedale di Empoli, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Martinelli
authors.forename: T
authors.initials: T
authors.lastname: Mazzei
authors.forename: S
authors.initials: S
authors.lastname: Fallani
authors.forename: G
authors.initials: G
authors.lastname: Palendri
authors.forename: A
authors.initials: A
authors.lastname: Novelli
authors.forename: P
authors.initials: P
authors.lastname: Periti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000378:metabolism*; D015296:Ceftizoxime / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged
chemical_list: D015296:Ceftizoxime