[Residues of active substances after consumption of contaminated food: status report on the evaluation of residues with examples of two drugs].
Pharmacokinetic models are presented for the computation of time courses of blood levels of drugs in man following the consumption of contaminated food. Mathematically, two linear systems of differential equations are set up for the donor organism (e.g., trout) and for the recipient, (e.g., man), where the first system generates the initial conditions for the second. Models of this kind are applied to the transfer of chloramphenicol to man via carp and trout (which had previously been administered this drug) and to the transfer of theophylline to infants via breast milk. Limiting concentration profiles are computed by constructing the most favourable and most adverse combinations of parameters with respect to drug elimination in both the donor and recipient organism.
Richter
O
O
Abteilung für Angewandte Statistik und Mathematik, Rheinischen Friedrich-Wilhelms-Universität Bonn, Bundesrepublik Deutschland.
Schmidt
T
T
Büning-Pfaue
H
H
Reinhardt
D
D
D000818:Animals; D002347:Carps; D002701:Chloramphenicol / Q000493:pharmacokinetics*; D005260:Female; D005506:Food Contamination; D006801:Humans; D007223:Infant; D008433:Mathematics; D008460:Meat; D008895:Milk, Human / Q000032:analysis; D008954:Models, Biological; D013806:Theophylline / Q000493:pharmacokinetics*; D014337:Trout
D002701:Chloramphenicol; D013806:Theophylline
Wirkstoff-Verbleib nach dem Verzehr rückstandshaltiger Lebensmittel. Statusbeschreibung für die Bewertung von Rückständen am Beispiel von zwei Arzneistoffen.