High-performance liquid chromatographic assay for the simultaneous measurement of two spironolactone analogues, 17 beta-hydroxy-3-oxo-17-pregn-4-ene-21-carboxylic acid-gamma-lactone 7 alpha-methyl ethyl ester and its 6 beta-hydroxylated derivative.
Jackson
L S
LS
Department of Drug Metabolism and Pharmacokinetics, G. D. Searle & Co. Ltd., Buckinghamshire, U.K.
Stafford
J E
JE
D000959:Antihypertensive Agents / Q000097:blood* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D013056:Spectrophotometry, Ultraviolet; D013148:Spironolactone / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
D000959:Antihypertensive Agents; D013148:Spironolactone; C006286:SC 26304; C058412:SC 30822