Biphasic effects of alcohol drinking on methamphetamine metabolism in man.
In methamphetamine (MAP) addicts, long-term ethanol ingestion 3-4 times per week induced an increased rate of p-hydroxylation of MAP and amphetamine (AMP). Simultaneous ingestion of ethanol and MAP inhibited both p-hydroxylation of MAP and AMP and N-demethylation of MAP in inebriated addicts. The p-hydroxylation of MAP and AMP was also significantly inhibited in daily drinkers despite the almost total absence of urinary ethanol. This suggests that the intensity of MAP-induced behavioral and psychological effects in MAP addicts may, in part, depend upon their drinking habits.
Shimosato
K
K
Department of Legal Medicine, Kawasaki Medical School, Okayama, Japan.
Oda
H
H
Ohmae
M
M
Tomita
M
M
Doi
Y
Y
D000328:Adult; D000428:Alcohol Drinking; D000435:Alcoholic Intoxication / Q000378:metabolism*; D000661:Amphetamine / Q000378:metabolism; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008297:Male; D008694:Methamphetamine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D019966:Substance-Related Disorders / Q000378:metabolism*; D010136:p-Hydroxyamphetamine / Q000652:urine
D008694:Methamphetamine; C005877:pholedrine; D000661:Amphetamine; D010136:p-Hydroxyamphetamine