title: Colorimetric determination of tobramycin in parenteral solutions.
abstract: A colorimetric method based on a reaction between tobramycin and alkaline copper sulphate solution has been proposed to quantify tobramycin in injections. The excipients present and normal saline did not interfere with the assay procedure. A tobramycin sample which was decomposed using either sulphuric acid or sodium hydroxide solution indicated fairly good stability on both sides of the pH scale.
authors.affiliation: Department of Pharmaceutics, University of Houston, TX 77030.
authors.forename: V
authors.initials: V
authors.lastname: Das Gupta
mesh_terms: D003124:Colorimetry / Q000379:methods*; D005947:Glucose; D010636:Phenols; D012965:Sodium Chloride; D012996:Solutions; D014031:Tobramycin / Q000032:analysis*
chemical_list: D010636:Phenols; D012996:Solutions; D012965:Sodium Chloride; D005947:Glucose; D014031:Tobramycin