title: The prognostic and therapeutic value of second-look laparotomy in advanced ovarian cancer.
abstract: Of 267 patients with ovarian cancer FIGO stages III and IV, 157 underwent second-look laparotomy after combination chemotherapy consisting of cis-platinum and cyclophosphamide with and without doxorubicin. At second-look operation 45% had macroscopic tumour, 15% microscopic tumour, and 40% complete pathological response. Survival 3 years after second look was: complete pathological response 74%; microscopic disease 24%; visible tumour less than 1 cm 28%; visible tumour greater than 1 cm 17%; negative cytology 59%; and positive cytology 18%. Of the patients with macroscopic tumour, 29% had all visible tumour removed at second look. Three-year survival for these patients was about 45%.
authors.affiliation: Department of Oncology, Odense University Hospital, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Bertelsen
authors.forename: M K
authors.initials: MK
authors.lastname: Hansen
authors.forename: P H
authors.initials: PH
authors.lastname: Pedersen
authors.forename: G
authors.initials: G
authors.lastname: Larsen
authors.forename: M
authors.initials: M
authors.lastname: Nyland
authors.forename: M
authors.initials: M
authors.lastname: Jacobsen
authors.forename: J E
authors.initials: JE
authors.lastname: Andersen
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007813:Laparotomy; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D011897:Random Allocation; D012086:Reoperation
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin