title: The TILT formula for brain lesions.
abstract: A formula to evaluate and grade brain lesions is reported. The formula is based on 4 descriptive factors which characterize the lesion severity and potential outcome on the subject. The factors are, type of lesion, intensity of lesion, location and time of lesion duration before therapy is applied (TILT). A relative value is assigned to each TILT factor and the sum of these values determines the severity of the injury or traumindex. The relative benefit of specific therapy can then be assessed quickly and objectively by applying its effect on TILT. Three examples picked at random from the literature, illustrate application of TILT comparing "claimed" and "apparent" benefit of specific treatments. The formula is useful for both model-induced basic and sustained clinical injuries of the brain.
authors.affiliation: Division of Neurosurgery, University of Ottawa, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: de la Torre
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000145:classification* / Q000175:diagnosis / Q000628:therapy; D005069:Evaluation Studies as Topic; D006801:Humans; D008959:Models, Neurological; D013997:Time Factors