Micronuclei test in routine smears from uterine cervix.
Micronuclei are intracytoplasmatic inclusion bodies formed from chromatin fragments or whole chromosomes. Their presence in cells is a reflection of chromosomal aberrations during cellular mitosis. The micronuclei in exfoliated cells of the cervix have been suggested to represent a marker of their malignant potential. The Authors present a study with a micronuclei test carried out on cervical smears. Moderate and severe dysplasia revealed a slightly higher frequency of micronuclei than the inflammatory and mild dysplasia. The Author suggest that the rising frequency of micronuclei in exfoliated cervical cells reflects a sustained mutagenesis in cervical epithelium.
Chakrabarti
R N
RN
Department of Pathology, Chittaranjan National Cancer Research Centre, Calcutta, India.
Dutta
K
K
D000328:Adult; D005260:Female; D006801:Humans; D015162:Micronucleus Tests; D008875:Middle Aged; D002578:Uterine Cervical Dysplasia / Q000648:ultrastructure*; D002583:Uterine Cervical Neoplasms / Q000648:ultrastructure*; D014626:Vaginal Smears