Studies of the effects of subacute treatment with N-(cyclopropylmethyl)-19-isopentylnororvinol (M320) on timing of parturition in the rat.
1. Administration of 10 micrograms kg-1 of the long lasting potent kappa- and weaker mu-opioid agonist N-(cyclopropylmethyl)-19-isopentylnororvinol (M320) twice daily from day 20 of gestation prolonged the internal gestation period of the rat and retarded the development of the offspring in the perinatal period. 2. The capacities of myometrial, placental and cervical tissues to produce prostaglandin E2 (PGE2) were not affected by M320 treatment. 3. During the period in which parturition normally occurred in saline-treated rats, foetal pituitary levels of immunoreactive oxytocin (ir-OXY) but not immunoreactive arginine-vasopressin (ir-AVP) were greater in M320-compared to saline-treated animals. Following the completion of parturition, foetal pituitary ir-OXY and ir-AVP levels continued to rise in saline-treated rats, but fell dramatically in rats treated subacutely with M320. 4. These data indicate that subacute treatment with M320 may inhibit foetal oxytocin release at term. This foetal OXY release may be a stimulus for the initiation of labour.
Evans
R G
RG
Department of Pharmacology, Monash University, Clayton, Victoria, Australia.
Rice
G E
GE
Olley
J E
JE
D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002584:Cervix Uteri / Q000378:metabolism; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D005865:Gestational Age; D007743:Labor, Obstetric / Q000187:drug effects*; D009019:Morphinans / Q000494:pharmacology*; D009215:Myometrium / Q000378:metabolism; D010121:Oxytocin / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D009019:Morphinans; D001127:Arginine Vasopressin; D010121:Oxytocin; C006084:N-(cyclopropylmethyl)-19-isopentylnororvinol hydrochloride; D015232:Dinoprostone