Effect of polyunsaturated fatty acids of the n-3 and n-6 series on lipid composition and eicosanoid synthesis of platelets and aorta and on immunological induction of atherosclerosis in rabbits.
The effect of dietary fish oil (rich in n-3 polyunsaturated fatty acids (PUFA], corn oil (rich in n-6 PUFA) and coconut oil (low in n-3 and n-6 PUFA) on the induction of atherosclerosis by serum sickness in rabbits was investigated over a 12-month period. Dietary fish oil led to a significant increase in the level of eicosapentaenoic acid (EPA) in all platelet phospholipid fractions and to a significant reduction in the level of platelet phosphatidylethanolamine arachidonic acid (AA). In aortic total phospholipids, rabbits given fish oil showed a significant reduction in AA and a significant increase in EPA. Rabbits given fish oil showed significantly lower collagen-induced platelet thromboxane A2 release and aortic production of 6-keto-PGF1 alpha. Serum total immune complex levels and anti-horse serum IgG levels were not influenced by diet. There was a significant reduction in total aortic atherosclerosis in fish oil-fed animals compared with coconut oil fed animals.
Bolton-Smith
C
C
Department of Nutrition, University of Southampton, U.K.
Gibney
M J
MJ
Gallagher
P J
PJ
Jewell
R
R
Hillier
K
K
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D001011:Aorta / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D001161:Arteriosclerosis / Q000276:immunology / Q000473:pathology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D003094:Collagen / Q000494:pharmacology; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011453:Prostaglandins / Q000097:blood / Q000378:metabolism*; D011817:Rabbits; D013928:Thromboxane A2 / Q000097:blood
D000936:Antigen-Antibody Complex; D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D008055:Lipids; D010743:Phospholipids; D011453:Prostaglandins; D013928:Thromboxane A2; D003094:Collagen; D002784:Cholesterol