X-ray microanalysis of the element content in the hearts of mice treated with digoxin.
The element content was detected by X-ray microanalysis in the hearts of mice treated with daily doses of 0.075 microgram digoxin for 12 days and compared with that of controls. Statistically significant differences were found for K and S, which were lower, and for P, which was higher following treatment with digoxin. In the sera of the treated mice Mg was slightly lower, whereas Ca and K levels were found to be elevated in comparison with those of nontreated animals. A possible explanation for these findings is discussed.
Djaldetti
M
M
Department of Medicine 'B', Hasharon Hospital, Petah Tiqwa, Israel.
Gilgal
R
R
Bessler
H
H
Magazanik
A
A
Zahavi
I
I
D000818:Animals; D002118:Calcium / Q000032:analysis; D004077:Digoxin / Q000494:pharmacology*; D004577:Electron Probe Microanalysis; D005260:Female; D006321:Heart / Q000187:drug effects*; D008274:Magnesium / Q000032:analysis; D051379:Mice; D008807:Mice, Inbred BALB C; D009206:Myocardium / Q000032:analysis*; D011188:Potassium / Q000032:analysis; D014131:Trace Elements / Q000032:analysis*
D014131:Trace Elements; D004077:Digoxin; D008274:Magnesium; D011188:Potassium; D002118:Calcium