[Preparation and testing of polymer drugs. 3. Binding of benzocaine to polyacrylic acid with a spacer].
epsilon-Aminocapronic acid (1) as spacer was introduced in polymeric drugs on the basis of polyacrylic acid. Benzocain served as model drug. Polymeric drugs were synthesized by copolymerisation with free acrylic acid. Not all functional groups of the carrier reacted with the model drug. This product showed a strong swelling during the release of the covalently bound drugs. Pancreatin was used for this investigation. A raising of the splitting rate was achieved by incorporation of the spacer in the polymeric drugs. However, the low rate of cleaving is not relevant for practical use.
Mank
R
R
Sektion Pharmazie, Martin Luther Universität Halle-Wittenberg, Saale.
Kala
H
H
Strube
M
M
D000180:Acrylic Resins; D001566:Benzocaine / Q000032:analysis*; D002626:Chemistry, Pharmaceutical; D005079:Excipients; D011108:Polymers
D000180:Acrylic Resins; D005079:Excipients; D011108:Polymers; C006903:carbopol 940; D001566:Benzocaine
Darstellung und Testung von Polymerpharmaka. 3. Mitteilung: Bindung von Benzocain über einen Spacer an Polyacrylsäure.