Trypanocidal activity of a new series of arsenical compounds the spiroarsorans.
The trypanocidal activity of a new class of arsenical compounds, the spiroarsorans, was investigated against Trypanosoma brucei brucei. The most active compound was found to be effective at a dose of 30 mg.kg-1 and had low toxicity.
Loiseau
P
P
Laboratoire de Parasitologie, Faculté de Pharmacie, Universite Paris-Sud, Chatenay-Malabry, France.
Bories
C
C
Gayral
P
P
Wolf
J G
JG
D000818:Animals; D001152:Arsenicals / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D051379:Mice; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D014346:Trypanosoma brucei brucei / Q000187:drug effects
D001152:Arsenicals; D013141:Spiro Compounds; D014344:Trypanocidal Agents