The acute response of indium-111 labelled platelets to arteriotomy closure.
A standard 40 mm arteriotomy was created in canine iliac and carotid arteries and then closed by either direct suture without a patch, with a vein patch or with a polytetrafluoroethylene patch (PTFE). The uptake of 111-Indium oxine labelled platelets at 2 hours after operation was compared between the groups. Arteriotomies closed with a PTFE patch demonstrated significantly greater platelet aggregation than those closed with a vein patch. Primary closure without a patch was associated with the least platelet uptake of all (PTFE versus vein patch, P less than 0.01; PTFE versus no patch, P less than 0.01; vein patch versus no patch, P less than 0.05). Light and electron microscopy confirmed the radioisotopic findings.
Nash
P A
PA
Surgical Professorial Unit, St. Vincent's Hospital, University of New South Wales, Sydney, Australia.
Lord
R S
RS
Zhang
H Q
HQ
Yeates
P
P
Whitfeld
M J
MJ
Freund
J
J
Pocock
N A
NA
Yeates
M
M
Goh
K H
KH
D000818:Animals; D001158:Arteries / Q000601:surgery* / Q000648:ultrastructure; D001792:Blood Platelets / Q000502:physiology* / Q000648:ultrastructure; D004285:Dogs; D007083:Iliac Artery / Q000601:surgery; D007084:Iliac Vein / Q000637:transplantation; D007205:Indium Radioisotopes; D008855:Microscopy, Electron, Scanning; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D011138:Polytetrafluoroethylene; D019736:Prostheses and Implants
D007205:Indium Radioisotopes; D011138:Polytetrafluoroethylene