Efficacy of verapamil in the salvage of failing random skin flaps.
Verapamil is a calcium channel blocker that inhibits mast cell degranulation, platelet aggregation, and neutrophil function and is a potent vasodilator. The efficacy of verapamil (20 mg/kg/day) to salvage a standard failing random skin flap in the rat was studied. In this study verapamil failed to benefit skin flap survival. The results are analyzed and presented.
Nichter
L S
LS
University of Southern California School of Medicine, Division of Plastic and Reconstructive Surgery, Los Angeles.
Sobieski
M W
MW
D000818:Animals; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013524:Surgical Flaps; D014664:Vasodilation / Q000187:drug effects; D014700:Verapamil / Q000008:administration & dosage*
D014700:Verapamil