title: Silicon as a trace nutrient.
abstract: Silicon performs an important role in connective tissue, especially in bone and cartilage. Silicon's primary effect in bone and cartilage appears to be on formation of the organic matrix. Bone and cartilage abnormalities are associated with a reduction in matrix components, resulting in the establishment of a requirement for silicon in collagen and glycosaminoglycan formation. Additional support for silicon's metabolic role in connective tissue is provided by the finding that silicon is a major ion of osteogenic cells, especially high in the metabolically active state of the cell. Further studies also indicate that silicon participates in the biochemistry of subcellular enzyme-containing structures. Silicon also forms important relationships with other elements. Although it is clear from the body of recent work that silicon performs a specific metabolic function, a structural role has been proposed for silicon in connective tissue. A relationship established between silicon and aging probably relates to glycosaminoglycan changes.
authors.affiliation: School of Public Health, University of California, Los Angeles 90024.
authors.forename: E M
authors.initials: EM
authors.lastname: Carlisle
mesh_terms: D000375:Aging; D000818:Animals; D001846:Bone Development / Q000187:drug effects; D002356:Cartilage / Q000032:analysis / Q000254:growth & development; D002645:Chickens; D003238:Connective Tissue / Q000032:analysis* / Q000254:growth & development; D004032:Diet; D008297:Male; D009928:Organ Specificity; D051381:Rats; D012016:Reference Values; D012828:Silicones / Q000032:analysis* / Q000172:deficiency / Q000494:pharmacology; D014131:Trace Elements
chemical_list: D012828:Silicones; D014131:Trace Elements