title: Protection against carbon tetrachloride-induced hepatotoxicity by protein A.
abstract: Protection from carbon tetrachloride (CCL4)-induced hepatotoxicity by protein A was assessed histologically in rats. Carbon tetrachloride exposure produced swollen, vacuolated and necrotic cells in the centrilobular region of the hepatocyte in rats. Animals given protein A prior to and during CCL1 treatment showed a complete absence of hepatic lesions. Our study showed that protein A, a potent immunomodulator, has the potential to reduce liver injury caused by carbon tetrachloride, a known hepatotoxin in the rat.
authors.affiliation: Preventive Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
authors.forename: K P
authors.initials: KP
authors.lastname: Singh
authors.forename: A K
authors.initials: AK
authors.lastname: Saxena
authors.forename: S I
authors.initials: SI
authors.lastname: Zaidi
authors.forename: P D
authors.initials: PD
authors.lastname: Dwivedi
authors.forename: S P
authors.initials: SP
authors.lastname: Srivastava
authors.forename: P K
authors.initials: PK
authors.lastname: Seth
authors.forename: P K
authors.initials: PK
authors.lastname: Ray
mesh_terms: D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology / Q000517:prevention & control*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D008099:Liver / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013205:Staphylococcal Protein A / Q000627:therapeutic use*
chemical_list: D013205:Staphylococcal Protein A