An in vitro comparative study on the effect of amphotericin B, econazole, and 5-fluorocytosine on Naegleria fowleri, Naegleria australiensis, and Naegleria australiensis s.sp. italica.
We tested in vitro amphotericin B (AMP-B), econazole (ECO), and 5-fluorocytosine (5-FC) on pathogenic Naegleria fowleri (KUL strain), Naegleria australiensis s.sp. italica (AB-T-F3, original strain) to assess their sensitivity to chemotherapeutic compounds. Previous reports have shown the polyene antibiotic AMP-B to be the most active agent. It was, however, much more active on N. fowleri than on N. australiensis and N. australiensis s.sp italica. 5-FC and ECO gave rise to non appreciable effect at non-toxic corresponding dosages in vivo. The results of these in vitro tests are discussed.
Scaglia
M
M
Department of Infectious Diseases, University of Pavia, Italy.
Gatti
S
S
Bernuzzi
A M
AM
Cevini
C
C
Chichino
G
G
Rondanelli
E G
EG
D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D004464:Econazole / Q000494:pharmacology*; D005437:Flucytosine / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D009253:Naegleria / Q000187:drug effects* / Q000254:growth & development
D007093:Imidazoles; D004464:Econazole; D000666:Amphotericin B; D005437:Flucytosine