Effects of a calcium antagonist (nifedipine) on cats in live E. coli bacteriemic shock.
The effects of a calcium antagonist, nifedipine, on cardiovascular reactions and on gastrointestinal mucosal integrity was studied in a standardized feline bacteriemic model. Nifedipine pretreatment delayed the development of cardiovascular derangement and reduced the severity of the intestinal but not the gastric mucosal injury. The effect on the intestinal mucosa could be due to the delayed development of hypotensive shock but also to a protective effect on the superficial mucosal cells.
Bosson
S
S
Dept. of Surgery, University of Lund, Malmö General Hospital, Sweden.
Fält
K
K
Haglund
U
U
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology*; D002415:Cats; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D009543:Nifedipine / Q000494:pharmacology*; D012016:Reference Values; D012772:Shock, Septic / Q000473:pathology / Q000503:physiopathology*; D013152:Splanchnic Circulation / Q000187:drug effects
D009543:Nifedipine