title: Effect of buthionine sulfoximine, an inhibitor of glutathione biosynthesis, on the selenium-induced lethality in mice.
abstract: The effect of buthionine sulfoximine (BSO), an inhibitor of glutathione (GSH) biosynthesis, on the selenium induced-lethality was examined in mice. A single injection of BSO (500 mg/kg, i.p.) markedly decreased the concentration of GSH in the liver after 5 hr. The acute lethality induced by selenium was greatly increased in BSO-treated mice. In contrast, the selenium induced-lethality decreased by pre- and post-treatments of cysteine (100 mg/kg, i.p.) in mice.
authors.affiliation: Cancer Research Institute, Tohoku College of Pharmacy, Sendai, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ishikawa
authors.forename: G
authors.initials: G
authors.lastname: Takayanagi
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D019328:Buthionine Sulfoximine; D003545:Cysteine / Q000494:pharmacology; D004347:Drug Interactions; D005978:Glutathione / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D012643:Selenium / Q000633:toxicity*
chemical_list: D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D005978:Glutathione; D012643:Selenium; D003545:Cysteine