Sequence-defined dimer block synthesis from unprotected nucleoside.
mediates to synthesize the oligodeoxynucleotides have been synthesize otected nucleoside using morpholinophosphorditetrazolide. From these sequence-defined oligodeoxynucleotides were also synthesized. The gen is composed of following steps; a) reaction of 5'-O-protected nucleo orpholinophosphorditetrazolide (phosphitilation), b) reaction of the nucleoside phosphoramidite with the second nucleoside (condensation), ueous oxidation with t-BuOOH (oxidation). RE 1/hlp F2/cmt F3/ext F4/can F5/nxt F6/ins F7/up F8/dwn F9/fin
Shimidzu
T
T
Division of Molecular Engineering, Graduate School of Engineering, Kyoto University, Japan.
Ozaki
H
H
Yamoto
S
S
Maikuma
S
S
Honda
K
K
Yamana
K
K
D007202:Indicators and Reagents; D009705:Nucleosides; D009711:Nucleotides / Q000138:chemical synthesis*; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D009705:Nucleosides; D009711:Nucleotides; D009838:Oligodeoxyribonucleotides