Metabolism of homoorientin by human intestinal bacteria.
As a part of our studies on the metabolism of bioactive compounds from oriental medicines by intestinal flora, homoorientin, a C-glycosylflavonoid, was anaerobically incubated with a human intestinal bacterial mixture. Homoorientin was transformed to 6-C-glucosyleriodictyol, (+/-)-eriodictyol, luteolin, 3,4-dihydroxyphenylpropionic acid, and phloroglucinol. A novel cleavage of the C-glycosyl bond was discovered for the first time by using intestinal bacteria.
Hattori
M
M
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Shu
Y Z
YZ
el-Sedawy
A I
AI
Namba
T
T
Kobashi
K
K
Tomimori
T
T
D001421:Bacteria, Anaerobic / Q000378:metabolism; D005243:Feces / Q000382:microbiology; D005419:Flavonoids / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology*; D047311:Luteolin; D010946:Plants, Medicinal / Q000032:analysis; D013997:Time Factors
D005419:Flavonoids; C057912:homoorientin; D047311:Luteolin