[Operability of primary inoperable pelvic tumors by preoperative regional hyperthermia in combination with systemic chemotherapy exemplified by Ewing's sarcoma].
Failure of local tumor control is of critical importance in the clinical management of large pelvic tumors. For bulky sarcomas of the pelvis a new treatment strategy could be of importance in the future using preoperative regional hyperthermia combined with systemic chemotherapy. In our case history of a patient with unresectable Ewing sarcoma of the pelvis no tumor response could be observed during multi-drug chemotherapy alone. However, after treatment with regional hyperthermia combined with systemic chemotherapy, the tumor mass became resectable and was separated from the adjacent tissue by a fibrotic pseudocapsule. Histological evaluation of the tumor tissue showed a complete change of the pattern.
Böhm
P
P
Orthopädische Klinik, Klinikum Grosshadern.
Wirth
C J
CJ
Issels
R
R
Riess
H
H
Dressler
W
W
Gokel
J M
JM
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006428:Hemipelvectomy; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D010384:Pelvic Bones / Q000601:surgery*; D010386:Pelvic Neoplasms / Q000188:drug therapy / Q000601:surgery*; D012512:Sarcoma, Ewing / Q000188:drug therapy / Q000601:surgery*
Operabilität primär inoperabler Beckentumoren durch präoperative regionale Hyperthermie in Kombination mit systemischer Chemotherapie am Beispiel eines Ewing-Sarkoms.