Dermal carcinogenic activity of petroleum-derived middle distillate fuels.
In general, the carcinogenic potential of petroleum-derived materials is related to the polycyclic aromatic hydrocarbon (PAH) content. Thus it has been assumed that liquids which boil below the PAH distillation range (i.e., below approx. 370 degrees C (700 degrees F) would not be carcinogenic. Several early studies supported this conclusion but were of relatively short duration. Several recent and more rigorous studies have shown that repeated application of certain petroleum-derived materials boiling between approximately 177-370 degrees C (350-700 degrees F) (i.e., middle distillate fuels) can produce tumors in mouse skin. The current studies assessed the tumorigenic potential of a series of middle distillates which varied with respect to boiling range, composition, and source of blending stocks. All of the samples produced evidence of weak tumorigenic activity which was characterized by low tumor yields and long median latencies. However, the majority of the tumor yields were significantly different from the control. There were no apparent differences in response among the samples. Thus the various parameters examined did not substantially influence tumor outcome. In particular, there was no association of tumorigenic activity with aromatic carbon content; this finding, coupled with evidence that PAH levels were low, suggested that the tumorigenic responses were not PAH-dependent. In addition to the tumors, there was evidence of non-neoplastic dermal changes including hyperplasia. These may have contributed to the tumorigenic responses; however, the actual mechanism of tumor induction is unknown.
Biles
R W
RW
Exxon Biomedical Sciences, Inc., East Millstone, NJ 08875-2350.
McKee
R H
RH
Lewis
S C
SC
Scala
R A
RA
DePass
L R
LR
D000279:Administration, Cutaneous; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005648:Fuel Oils / Q000032:analysis / Q000633:toxicity*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010578:Petroleum / Q000633:toxicity*; D012878:Skin Neoplasms / Q000139:chemically induced*
D005648:Fuel Oils; D010578:Petroleum