Effects of fetal urinary corticosteroids, catecholamines and kallikrein on PGE2 synthesis in monolayer cultures of human amnion and chorion cells.
We have studied the effects of several compounds isolated from fetal urine on the production of PGE2 by amnion and chorion cells which were maintained in primary monolayer culture. We conclude that desoxycorticosterone and vanillylmandelic acid stimulate PGE2 synthesis by amnion, but adrenaline and kallikrein increase the biosynthesis of PGE2 by chorion. These data suggest that human fetal urine could play a major role in events of parturition.
Acker
G M
GM
INSERM Unité 187, Clamart, France.
Pesty
A
A
D000305:Adrenal Cortex Hormones / Q000652:urine*; D000450:Aldosterone / Q000494:pharmacology; D000650:Amnion / Q000187:drug effects / Q000378:metabolism*; D002395:Catecholamines / Q000494:pharmacology*; D002478:Cells, Cultured; D002823:Chorion / Q000187:drug effects / Q000378:metabolism*; D003900:Desoxycorticosterone / Q000494:pharmacology; D015232:Dinoprostone / Q000096:biosynthesis*; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D007610:Kallikreins / Q000378:metabolism*; D011247:Pregnancy; D014642:Vanilmandelic Acid / Q000494:pharmacology
D000305:Adrenal Cortex Hormones; D002395:Catecholamines; D003900:Desoxycorticosterone; D000450:Aldosterone; D014642:Vanilmandelic Acid; D007610:Kallikreins; D015232:Dinoprostone; D004837:Epinephrine