title: The poly(U) translational capacity of Fischer 344 rat liver does not deteriorate with age and is not affected by dietary regime.
abstract: The translational capacity of ribosomes isolated from the livers of young (60-170 days, n = 13) and old (26.5 months, n = 11) Fischer 344 rats was assessed by poly(U)-directed [3H]phenylalanine incorporation. Run-off ribosomes and S100 supernatant were separately prepared from each individual liver. Ribosome concentrations were carefully measured. Individual differences were seen among young rats and among old rats; however, when considered as a group, the old rats, whether diet-restricted or fed ad libitum, translated poly(U) as well, or almost as well, as the young ones.
authors.affiliation: Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montréal, Québec, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Laughrea
authors.forename: J
authors.initials: J
authors.lastname: Latulippe
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D004032:Diet; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D010649:Phenylalanine / Q000378:metabolism; D011072:Poly U / Q000235:genetics*; D014176:Protein Biosynthesis; D051381:Rats; D011916:Rats, Inbred F344; D012270:Ribosomes / Q000378:metabolism
chemical_list: D011072:Poly U; D010649:Phenylalanine