[The mechanisms of memory disorders at the stages in its acquisition and fixation].
The blockade of cholinergic system with scopolamine (10 mg/kg) did not impair the process of memory acquisition in rats but disrupted the process of memory fixation or consolidation, the disturbance stemming from the ketamine-blocked ion-channels of nicotinic receptors. Both scopolamine and ketamine impaired the process of memory recall, being more efficient in the case of ketamine. Piracetam (40 mg/kg) diminished the impair of fixation induced with scopolamine but did not affect the ketamine-induced impairment of memory acquisition.
Sprints
A M
AM
D000647:Amnesia / Q000139:chemically induced / Q000503:physiopathology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D007649:Ketamine / Q000494:pharmacology; D008569:Memory Disorders / Q000209:etiology* / Q000503:physiopathology; D008570:Memory, Short-Term / Q000187:drug effects* / Q000502:physiology; D010889:Piracetam / Q000494:pharmacology; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology; D012601:Scopolamine / Q000494:pharmacology; D013997:Time Factors
D011976:Receptors, Muscarinic; D007649:Ketamine; D012601:Scopolamine; D010889:Piracetam
O mekhanizmakh rasstroĭstv pamiati na étapakh formirovaniia i fiksatsii.