Changes in the morphology of Ehrlich ascites tumour cells caused by hyperosmotic media.
It was found that Ehrlich ascites tumour cells undergo significant morphology changes in media in which osmolarity is increased by NaCl or Hanks' balanced salt solution. The morphology changes include formation of filopodia- and lamellipodia-like cell surface protrusions. Their formation is enhanced by an addition of cytochalasin B. The data obtained suggest that both changes in plasma membrane properties and changes in activity of contractile apparatus participate in the formation of cell surface protrusions.
Kajstura
J
J
Department of Cell Biology, Jan Zurzycki Institute of Molecular Biology, Jagellonian University, Kraków, Poland.
Korohoda
W
W
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000648:ultrastructure*; D003470:Culture Media / Q000494:pharmacology; D003571:Cytochalasin B / Q000494:pharmacology; D003599:Cytoskeleton / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009994:Osmolar Concentration; D012965:Sodium Chloride / Q000493:pharmacokinetics / Q000494:pharmacology*
D003470:Culture Media; D003571:Cytochalasin B; D012965:Sodium Chloride