title: [New derivatives of carminomycin and rubomycin].
abstract: For preparing new semisynthetic analogs of anthracycline antibiotics, hydrolysis of 13-dimethylketals of 14-bromrubomycin and 14-brom-arminomycin in solution of diluted hydrochloric acid was studied. It was shown that such hydrolysis yielded 14-chlorrubomycin and 14-chlorcarminomycin. Conditions for separating the mixture of 14-chlor- and 14-bromrubomycins and the mixture of 14-chlor- and 14-bromcarminomycins by HPLC were developed. Interaction of 14-chlorine derivatives of rubomycin and carminomycin with potassium formate in the presence of the crown ether yielded 14-formyloxy derivatives of rubomycin and carminomycin. Interaction of rubomycin and carminomycin with formic acid in the presence of N-oxysuccinimide and dicyclohexylcarbodiimide resulted in formation of N-formyl derivatives of rubomycin and carminomycin.
authors.forename: E N
authors.initials: EN
authors.lastname: Olsuf'eva
authors.forename: L G
authors.initials: LG
authors.lastname: Aleksandrova
authors.forename: B V
authors.initials: BV
authors.lastname: Rozynov
authors.forename: N P
authors.initials: NP
authors.lastname: Potapova
mesh_terms: D002360:Carubicin / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D006868:Hydrolysis
chemical_list: D002360:Carubicin; D003630:Daunorubicin
vernacular_title: Novye proizvodnye karminomitsina i rubomitsina.