The effects of ranitidine and cysteamine on intestinal metaplasia induced by X-irradiation in rats.
The influence of ranitidine and cysteamine on intestinal metaplasia was examined in 7-month-old male Crj: CD (SD) rats. At the age of 5 weeks, the animals were treated with 10 Gy doses of X-rays at 3-day intervals up to a total of 20 Gy in the gastric region, and 6 months after irradiation, the rats received either ranitidine (0.02% in diet) or cysteamine (0.1% in drinking water) for 2 months. The incidence and number of intestinal metaplasia with alkaline phosphatase-positive foci in rats given X-rays and cysteamine (group 4) were significantly low compared with those in rats given X-rays and ranitidine (group 3) (p less than 0.01). In both the pyloric and the fundic gland mucosae, the average numbers of type C metaplasia (intestinal crypts with Paneth cells) and total numbers of metaplastic foci in rats of group 3 were much higher than those in group 4 (P less than 0.05). The present results showed that the occurrence of intestinal metaplasia was significantly increased after administration of ranitidine and decreased by cysteamine.
Watanabe
H
H
Department of Cancer Research, Hiroshima University, Japan.
Kamikawa
M
M
Nakagawa
Y
Y
Takahashi
T
T
Ito
A
A
D000818:Animals; D003543:Cysteamine / Q000494:pharmacology*; D007422:Intestines / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D008297:Male; D008679:Metaplasia / Q000209:etiology; D011899:Ranitidine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014965:X-Rays / Q000009:adverse effects
D003543:Cysteamine; D011899:Ranitidine