Some insights into the variations in antipyrine pharmacokinetics in the rat.
Antipyrine plasma disposition and urinary metabolic profile studies conducted in this laboratory between 1984 and 1987 are reported. A comparison of this data is made to a previous report of temporal variation in antipyrine plasma disposition parameters over a 18 month period. It is suggested that antipyrine plasma disposition parameters may not be sensitive indicators of temporal variation, but that variation in the metabolic profile might provide such evidence.
Shrewsbury
R P
RP
Division of Pharmaceutics, School of Pharmacy University of North Carolina, Chapel Hill 27599-7360.
White
L G
LG
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D007275:Injections, Intravenous; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains
C007983:4-hydroxyantipyrine; C031820:3-hydroxymethylantipyrine; D000983:Antipyrine