Liposome-bound cyclosporine: aqueous and vitreous level after subconjunctival injection.
The concentration of cyclosporine in the aqueous and vitreous humors of albino rabbits was measured, using HPLC at intervals of 24, 48, 96, and 192 hours after subconjunctival injections of 2.5 mg of free or liposome-bound cyclosporine. The aqueous concentration was reasonably high in both groups until day 4: 1050 nanograms per milliliter in the group receiving free cyclosporine, and 1438 nanograms per milliliter in the group receiving liposome-bound cyclosporine. The vitreous concentration was very low in both groups.
Alghadyan
A A
AA
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans.
Peyman
G A
GA
Khoobehi
B
B
Milner
S
S
Liu
K R
KR
D000818:Animals; D001082:Aqueous Humor / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D003228:Conjunctiva / Q000187:drug effects; D003524:Cyclosporins / Q000008:administration & dosage*; D004337:Drug Carriers; D007267:Injections; D008081:Liposomes; D011817:Rabbits; D013997:Time Factors; D014822:Vitreous Body / Q000032:analysis*
D003524:Cyclosporins; D004337:Drug Carriers; D008081:Liposomes