title: Prevention of calcium-induced membrane structural alterations in erythrocyte membranes by flunarizine.
abstract: The calcium antagonist flunarizine is shown to be able to prevent particle aggregation, membrane aggregation and blebbing resulting from elevated calcium concentrations. The anti-ischemic effects of flunarizine may therefore result in part from its ability to directly interfere with calcium-membrane interactions and thus prevent the lethal membrane reorganizations which occur after a period of ischemia during intracellular calcium overload.
authors.affiliation: Institute of Molecular Biology, University of Utrecht, The Netherlands.
authors.forename: P G
authors.initials: PG
authors.lastname: Thomas
authors.forename: A G
authors.initials: AG
authors.lastname: Zimmermann
authors.forename: A J
authors.initials: AJ
authors.lastname: Verkleij
mesh_terms: D002118:Calcium / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000648:ultrastructure; D005444:Flunarizine / Q000494:pharmacology*; D005614:Freeze Fracturing; D006801:Humans; D066298:In Vitro Techniques; D008854:Microscopy, Electron
chemical_list: D005444:Flunarizine; D002118:Calcium