Evaluation of a procedure to measure the time course of a drug's behavioral action.
The utility of a novel procedure to examine a drug's time course of behavioral action was evaluated. Time- and dose-effect relations for the antiepilepsy drug methsuximide were determined in pigeons during 12-hr overnight sessions through the use of a multiple variable-interval 60-sec extinction (mult VI EXT) schedule of food delivery. The VI 60-sec components were programmed for the first 10 min of each hour and were followed by 50-min EXT components. Methsuximide produced dose-dependent decreases in rate of responding; the higher the dose, the longer the duration of effect. The present procedure appears to be useful for determining effective presession injection intervals and time-effect relations.
Schlinger
H
H
Department of Psychology, Western Michigan University, Kalamazoo 49008-3899.
Poling
A
A
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D010856:Columbidae; D013388:Succinimides / Q000494:pharmacology; D013997:Time Factors
D000927:Anticonvulsants; D013388:Succinimides; C100286:methsuximide