title: [Measurement of local cerebral blood flow by computerized tomography with inhalation of stable xenon and curve-fitting method].
abstract: Non-invasive methods are described for estimating local cerebral blood flows (LCBF) and local partition coefficients (L lambda) during inhalation of 30% stable xenon gas (Xe) in oxygen during CT scanning. After the denitrogenation with pure oxygen breathing, 30% Xe is inhaled for four minutes to minimize subanesthetic effects with a rubber face-mask and the delivery system of Xe. Local time-delta Hounsfield units curve during the Xe wash-in and wash-out phase is utilized in order to calculate L lambda and LCBF using a least squares curve fitting analysis. Calculated L lambda and LCBF with the new method manifested reasonable distribution between the grey and white matters, and reproducibility was excellent in our study. Several case studies of patients with cerebral infarction are presented to demonstrate the characterization of L lambda and LCBF patterns in various tissues and theoretical grounds underlying the new method of curve fitting analysis are discussed.
authors.affiliation: Department of Neurosurgery, Osaka Neurological Institute, Toyonaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Touho
authors.forename: J
authors.initials: J
authors.lastname: Karasawa
authors.forename: H
authors.initials: H
authors.lastname: Shishido
authors.forename: T
authors.initials: T
authors.lastname: Tazawa
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Asai
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Yasue
authors.forename: M
authors.initials: M
authors.lastname: Kagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kuriyama
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging*; D002544:Cerebral Infarction / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D014057:Tomography, X-Ray Computed; D014979:Xenon Isotopes / Q000008:administration & dosage
chemical_list: D014979:Xenon Isotopes