title: The early risk of multiple sclerosis after optic neuritis.
abstract: Serial brain MRI was performed in 53 patients with clinically isolated optic neuritis. Using clinical and imaging evidence for relapse, multiple sclerosis developed within a mean of 12 months in 19 of 34 cases (56%) with brain lesions at presentation, and in only 3 of 19 cases (16%) without (Relative Risk = 6.8, p less than 0.005).
authors.affiliation: Institute of Neurology, London, UK.
authors.forename: D H
authors.initials: DH
authors.lastname: Miller
authors.forename: I E
authors.initials: IE
authors.lastname: Ormerod
authors.forename: W I
authors.initials: WI
authors.lastname: McDonald
authors.forename: D G
authors.initials: DG
authors.lastname: MacManus
authors.forename: B E
authors.initials: BE
authors.lastname: Kendall
authors.forename: D P
authors.initials: DP
authors.lastname: Kingsley
authors.forename: I F
authors.initials: IF
authors.lastname: Moseley
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis*; D009900:Optic Nerve / Q000473:pathology; D009902:Optic Neuritis / Q000175:diagnosis*