Studies on dressings for treatment of mucous membranes of oral cavity. Part 2: Influence of hydrophilizing substances on properties of hydrogel dressings comprising Kunitz protease inhibitor.
Resistance of the dressings against washing out depends upon concentrations of methylcellulose or sodium salt of carboxymethylcellulose, and upon concentrations of glycerol, 1,2-propylene glycol and polyoxyethylene glycol 400. For the determined group of dressings the ratio of washing out times in 0.9% sodium chloride solution to washing out times in distilled water remains constant. A similar relation has been observed for washing out times of the dressings in vivo compared to those in vitro in 0.9% solution of sodium chloride. The pharmaceutical availability of the Kunitz type protease inhibitor depends upon composition of the gel forming and hydrophylizing substances in the dressings. The rheological characteristics of the dressings comprise a flow limit and thixotropic properties. The initial clinical examinations proved that the dressings alleviated symptoms of paradontopathy.
Małecka
K
K
Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical Academy, Wroclaw, Poland.
Kubis
A
A
D001458:Bandages; D005079:Excipients; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D009061:Mouth Mucosa / Q000187:drug effects*; D011092:Polyethylene Glycols; D012212:Rheology; D014360:Trypsin Inhibitor, Kunitz Soybean / Q000008:administration & dosage*; D014361:Trypsin Inhibitors / Q000008:administration & dosage*; D014783:Viscosity
D005079:Excipients; D014361:Trypsin Inhibitors; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D014360:Trypsin Inhibitor, Kunitz Soybean