[The spectra of de novo synthesized proteins in the early stages of radiation death of lymphocytes in the rat thymus].
A comparative study was made of the spectrum of thymus cell proteins in the control and gamma-irradiated rats. It was shown that early after irradiation a group of proteins appeared in rat thymus cells which had not been traced, or detected in much lower amounts, in intact cells. Part of those polypeptides were referred to general stressor proteins, the other were specific for the effect of ionizing radiation. The spectrum of de novo synthesized enzymes changed with time after irradiation. Some of the proteins were found to induce chromatin degradation in the control cells and, presumably, to be involved in the implementation of the programmed cell death.
Zhivotovskiĭ
B D
BD
Puchkova
L V
LV
Denezhkina
V V
VV
Gaĭtskhoki
V S
VS
Khanson
K P
KP
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D005720:Gamma Rays; D006360:Heat-Shock Proteins / Q000096:biosynthesis; D008214:Lymphocytes / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D014176:Protein Biosynthesis; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D051381:Rats; D013950:Thymus Gland / Q000378:metabolism / Q000528:radiation effects*; D013997:Time Factors
D006360:Heat-Shock Proteins
Issledovanie spektra de novo sintezirovannykh belkov na rannykh stadiiakh radiatsionnoĭ gibeli limfotsitov timusa krysy.