[Polyurethane catheters and antineoplastic chemotherapy. An experimental study].
An in vitro study of the effect of cytotoxic drugs on polyurethane catheters was carried out. The drugs used--vincristine, doxorubicin, cisplatin and carmustine--damage the surface of silicone elastomer catheters. The irregularities produced seem to be preferential sites for thrombus formation and adhesion of bacterial microcolonies. Electron microscopy examination of the catheters dipped in the drug solutions for different time intervals revealed the appearance of different patterns of damage. The irregularities produced seemed to be less pronounced than for silicone catheters. Polyurethane was highly sensitive to doxorubicin. These changes could well have clinical repercussions. The compatibility of catheters and drugs should be routinely tested before being put on the market.
Ranchère
J Y
JY
Centre Régional de Lutte contre le Cancer, Lyon.
Tabone
E
E
Latour
J F
JF
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002405:Catheterization, Central Venous; D004869:Equipment Safety; D008855:Microscopy, Electron, Scanning; D011140:Polyurethanes; D012107:Research Design
D011140:Polyurethanes
Cathéters en polyuréthane et chimiothérapie antinéoplasique. Etudeexpérimentale.