title: Prevention of fissure caries in rats by dietary F supplement with and without topical application of F and Sr + F.
abstract: In our previous studies, combined dietary and topical fluoride have shown to be more effective than each alone. Moreover, supplementation of chlorhexidine-fluoride solution with Sr was beneficial for caries prevention in rats. In the present study, the caries-preventive effect of fluoride added to the diet plus F and/or Sr applications was studied in two experiments with rats. One group received dietary fluoride supplement only. In other groups, either a Sr solution, a fluoride varnish, or a Sr solution plus fluoride varnish were applied to newly erupted molars. In addition, one group received both topical applications of Sr + F and dietary fluoride. Caries development was followed longitudinally during periods of 15, 30 or 54 days. The greatest and most significant reduction of caries resulted from the combination of fluoride varnish plus dietary fluoride supplement. Treatment with Sr solution at the beginning of the experiment had no effect on caries either alone or combined with fluoride varnish. It was found that caries increased rapidly and then levelled off after the 30-days feeding period in all groups. In the treatment groups, however, caries was arrested at a considerably lower level than in the control group.
authors.affiliation: Department of Preventive Dentistry and Cariology, University of Kuopio, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Seppä
authors.forename: I
authors.initials: I
authors.lastname: Nykänen
authors.forename: S
authors.initials: S
authors.lastname: Spets-Happonen
authors.forename: H
authors.initials: H
authors.lastname: Luoma
mesh_terms: D000287:Administration, Topical; D000818:Animals; D003731:Dental Caries / Q000517:prevention & control*; D003750:Dental Fissures / Q000382:microbiology / Q000517:prevention & control*; D004032:Diet; D004037:Diet, Cariogenic; D005260:Female; D005459:Fluorides / Q000008:administration & dosage* / Q000627:therapeutic use; D005460:Fluorides, Topical / Q000627:therapeutic use*; D008137:Longitudinal Studies; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013291:Streptococcus / Q000502:physiology; D013324:Strontium / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D005460:Fluorides, Topical; D005459:Fluorides; D013324:Strontium