title: Ethanol induced skeletal muscle degeneration--role of calcium.
abstract: The ethanol induced skeletal muscle degeneration is multi-factorial. The morphological changes of the skeletal muscle are more pronounced in the mitochondria. The excessive concentration of calcium in the mitochondria, as shown by the electron-probe micro-analysis, within the first week of ethanol intoxication, even before the appearance of ultrastructural changes suggests that the calcium influx provokes the mitochondrial degeneration.
authors.affiliation: Department of Neurology, Medical College of Wisconsin, Milwaukee 53226.
authors.forename: J K
authors.initials: JK
authors.lastname: Baruah
authors.forename: M
authors.initials: M
authors.lastname: Washington
authors.forename: D
authors.initials: D
authors.lastname: Kinder
mesh_terms: D000437:Alcoholism / Q000473:pathology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004577:Electron Probe Microanalysis; D000431:Ethanol / Q000633:toxicity*; D008297:Male; D008854:Microscopy, Electron; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000648:ultrastructure; D009132:Muscles / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
chemical_list: D000431:Ethanol; D002118:Calcium