title: Vasculo-Behçet's disease: immunological study of the formation of aneurysm.
abstract: We report two patients with vasculo-Behçet's disease who had femoral and popliteal aneurysms. The resected aneurysms and occluded distal arteries were studied clinicopathologically. The most interesting features were prominent fibrosis of the adventitia including the surrounding tissue, venous occlusion, perivasculitis and deposits of C3, C4 and immunoglobulins (IgA, IgG and IgM) in the arterial wall and surrounding tissue. These findings indicate that the formation of aneurysm in vasculo-Behçet's disease is caused by destruction of the intimal and outer side of the arterial wall.
authors.affiliation: Second Department of Surgery, Kurume University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamana
authors.forename: K
authors.initials: K
authors.lastname: Kosuga
authors.forename: H
authors.initials: H
authors.lastname: Kinoshita
authors.forename: K
authors.initials: K
authors.lastname: Uraguchi
authors.forename: T
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Y
authors.initials: Y
authors.lastname: Hirata
authors.forename: H
authors.initials: H
authors.lastname: Akashi
authors.forename: T
authors.initials: T
authors.lastname: Nakayama
authors.forename: K
authors.initials: K
authors.lastname: Ohishi
mesh_terms: D000328:Adult; D000783:Aneurysm / Q000000981:diagnostic imaging / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D001528:Behcet Syndrome / Q000150:complications / Q000276:immunology / Q000473:pathology*; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011150:Popliteal Artery / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology; D011859:Radiography
chemical_list: D007136:Immunoglobulins; D003165:Complement System Proteins