title: [Trial of hepatitis B prophylaxis in children born to mothers carrying HBs antigen in New Caledonia].
abstract: A prophylaxis trial of hepatitis B at birth was carried out in New Caledonia. Ninety-nine newborns from women carrying hepatitis B antigen during pregnancy were immunized. The prophylaxis protocol was as follows: anti-HBs immunoglobulin and the first dose of vaccine at birth if the mother was HBe Ag+ or HBe Ag- without anti-HBe, only vaccination if the mother showed anti-HBe antibodies. 73.8% had anti-HBs antibodies when checked at 6 months; at the age of one year, this figure was 60.4%. Four months after the booster injection, 68.3% were anti-HBs positive. Among all these children, three of them were born to HBe Ag+ mothers became HBs Ag/HBe Ag positive. The control group studied showed that mother-infant vertical transmission was not the only route of contamination in children in New Caledonia.
authors.affiliation: Institut Pasteur de Nouméa, Nouvelle-Calédonie.
authors.forename: M
authors.initials: M
authors.lastname: Laille
authors.forename: B
authors.initials: B
authors.lastname: Brethes
authors.forename: J P
authors.initials: JP
authors.lastname: Moreau
authors.forename: J
authors.initials: J
authors.lastname: Pillot
mesh_terms: D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D006510:Hepatitis B Antibodies / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis* / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D007231:Infant, Newborn; D009510:New Caledonia; D011247:Pregnancy; D014765:Viral Vaccines
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D014765:Viral Vaccines
vernacular_title: Essai de prophylaxie de l'hépatite B chez les enfants nés de parturientes porteuses de l'antigène HBs en Nouvelle-Calédonie.