[Immunomodulating and analgesic activity of synthetic fragments of various proteins and immunopeptides].
The biological activity of certain new peptides synthesized by the classic methods of peptide chemistry is investigated. The characteristic feature of these peptides is that they are parts of the sequences of many naturally occurring proteins and immunopeptides (beta-lactoglobulin, vicilin, B-hordein, gamma-gliadin, histones, Thy-I-antigen, thymosin beta, leukocyte interferon, neutrophil peptides and others) tested by the computer methods. Most of the investigated peptides are shown to enhance E-rosette-forming activity of human T-lymphocytes and to possess the analgesic activity. In some cases the analgesic effect was antagonized by naloxone. The possible mechanism of appearance of such peptide fragments and their biological role in human organism is discussed.
Ivanova
V P
VP
Sorochinskaia
E I
EI
Lozhkina
T K
TK
Anokhina
V V
VV
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis; D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D002478:Cells, Cultured; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000276:immunology / Q000494:pharmacology*; D011506:Proteins / Q000138:chemical synthesis / Q000276:immunology / Q000494:pharmacology*; D012397:Rosette Formation
D000276:Adjuvants, Immunologic; D000700:Analgesics; D010446:Peptide Fragments; D011506:Proteins
Immunomoduliruiushchaia i anal'geticheskaia aktivnost' sinteticheskikh fragmentov razlichnykh belkov i immunopeptidov.