Allelic frequencies given the sample's common ancestral type.
A general formula is derived for finding the expected proportion of genes in a random sample of n genes which are of a particular allelic type given the type of the sample's common ancestor. Expressions of these expectations are obtained for the 2-allele, K-allele, infinitely many alleles, and stepwise mutation models. Numerical examples for the stepwise mutation model are also tabulated.
Beder
B
B
Mathematics Department, Monash University, Clayton, Victoria, Australia.
D000483:Alleles; D002460:Cell Line; D005787:Gene Frequency; D008957:Models, Genetic; D009154:Mutation; D011336:Probability