[Pathogenesis of cancer of the operated stomach].
Carcinoma in the postsurgical stomach has to be considered as a prognostically hopeless late complication in the wake of reflux-causing stomach operations. Morphological, autoradiographic, microbiological, and biochemical investigations of animal models and analyses of 19,595 postmortem records have supported the view that enterogastric reflux, bacterial colonisation, primarily by nitrate-reducing enterobacteria, alteration of the intragastric pH condition as well as consecutive morphological and functional changes to gastric mucosa are factors of pathogenetic relevance. Reflux-preventing surgical methods should be adopted to handle the problem, among them application of Roux-en-Y anastomosis or jejunal interposition following gastrectomy. Systematic postsurgical follow-up care is considered to be just as important.
Dittrich
S
S
Chirurgischen Klinik des Bezirkskrankenhauses Plauen.
Fleischer
G M
GM
D000368:Aged; D000714:Anastomosis, Surgical; D000818:Animals; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D005753:Gastric Mucosa / Q000473:pathology; D005757:Gastritis, Atrophic / Q000473:pathology; D005763:Gastroenterostomy; D006801:Humans; D008297:Male; D010437:Peptic Ulcer / Q000473:pathology; D011183:Postoperative Complications / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology*
Zur Pathogenese des Karzinoms im operierten Magen.