Serum and prostatic tissue concentrations of ofloxacin.
Serum concentrations of ofloxacin were determined in 28 patients, and prostatic tissue concentrations were analyzed in 26 patients, receiving a single 400-mg oral dose of the agent prior to transurethral prostatectomy. The maximum serum concentration was 5.198 micrograms/ml, the time of maximum concentration was 195.1 minutes, and the terminal half-life was 211.7 minutes. The prostatic tissue concentrations of ofloxacin were similar to those in serum (ratio, 1.06 +/- 0.37).
Fujita
K
K
Department of Urology, National Medical Center Hospital, Tokyo, Japan.
Munakata
A
A
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D011183:Postoperative Complications / Q000517:prevention & control; D011467:Prostate / Q000378:metabolism*; D011468:Prostatectomy; D014552:Urinary Tract Infections / Q000517:prevention & control
D015242:Ofloxacin