[Late effects of the hematotoxic action of antineoplastic antibiotics of the anthracycline group].
The morphological and functional states of hemopoiesis at late periods (up to 6 months) after using daunorubicin, carminomycin and doxorubicin, antitumor antibiotics of the anthracycline group in doses of 1/10 LD50 for 10 days were studied on 764 noninbred rats and 240 BALB/c mice. On various compensatory-functional models of hemopoiesis strain there was shown persisting inhibition of hematopoietic tissue functional activity and limited reserve reactions of granulocyto- and erythropoiesis 3 and to a lesser extent 6 months after the cytostatic action.
Gol'dberg
E D
ED
Novitskiĭ
V V
VV
Fursov
S E
SE
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D002360:Carubicin / Q000633:toxicity; D003630:Daunorubicin / Q000633:toxicity; D004317:Doxorubicin / Q000633:toxicity; D006410:Hematopoiesis / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; D002360:Carubicin; D003630:Daunorubicin
Otdalennye éffekty gematotoksicheskogo deĭstviia protivoopukholevykh antibiotikov gruppy antratsikinov.