title: Sebaceous gland hyperplasia following topical application of citral. An ultrastructural study.
abstract: Topical application of citral on male rat skin induces hyperplasia of the sebaceous glands. Ultrastructural study showed that this hyperplasia is manifested by an increase in number of the partially differentiated cells of the gland. Citral was found in fat droplets of the mature differentiated and partially differentiated cells. Because citral causes an increase in testosterone level, we conclude that the sebaceous gland hyperplasia is related to androgen activity.
authors.affiliation: Department of Dermatology, Beilinson Medical Center, Tel Aviv University, Sackler School of Medicine, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Sandbank
authors.forename: A
authors.initials: A
authors.lastname: Abramovici
authors.forename: R
authors.initials: R
authors.lastname: Wolf
authors.forename: E
authors.initials: E
authors.lastname: Ben David
mesh_terms: D000080462:Acyclic Monoterpenes; D000287:Administration, Topical; D000818:Animals; D006965:Hyperplasia; D008297:Male; D039821:Monoterpenes; D051381:Rats; D012627:Sebaceous Glands / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D013729:Terpenes / Q000633:toxicity*; D014801:Vitamin A / Q000037:antagonists & inhibitors
chemical_list: D000080462:Acyclic Monoterpenes; D039821:Monoterpenes; D013729:Terpenes; D014801:Vitamin A; C007076:citral