[Pharmacokinetics of isoniazid and rifampicin in an experiment and in clinical practice].
Efficacy of drugs in patients with pulmonary tuberculosis mostly depends on their concentration in organs and tissues. To show distribution profiles of antituberculous drugs in patients in organs and tissues of experimental animals after their administration alone or in combination, pharmacokinetic parameters of isoniazid and rifampicin were studied. The drug concentrations, half-lives and distribution volumes were determined in 50 patients and 60 experimental animals. It was observed that after combined use of isoniazid and rifampicin their concentrations in the lung tissue and liver of the experimental animals increased which led to increasing their half-lives in patients.
Karkishchenko
N N
NN
Khoron'ko
V V
VV
Anisimova
N B
NB
Vorob'ev
V S
VS
Lavrushko
A N
AN
D000818:Animals; D005260:Female; D006207:Half-Life; D006801:Humans; D007538:Isoniazid / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D012293:Rifampin / Q000493:pharmacokinetics*
D007538:Isoniazid; D012293:Rifampin
Farmakokinetika izoniazida i rifampitsina v éksperimente i klinike.