[Mutagenic properties of phosphotriester analogs of oligodeoxyribonucleotides].
The high effectivity of using phosphotriester analogs of oligonucleotides for aimed mutagenesis in vitro and in vivo was shown. A general scheme, describing the mutagenic effects of phosphotriester analogs of oligonucleotides and their natural homologs, was derived by analysis of data on the structures of the obtained mutants. This scheme can serve as a foundation for selecting the structure of effective agents for aimed mutagenesis.
Petrenko
V A
VA
Kipriianov
S M
SM
Boldyrev
A N
AN
Pozdniakov
P I
PI
D001483:Base Sequence; D003090:Coliphages / Q000235:genetics; D004270:DNA, Circular / Q000235:genetics; D008957:Models, Genetic; D009152:Mutagenicity Tests; D009153:Mutagens; D009838:Oligodeoxyribonucleotides / Q000633:toxicity*; D010755:Organophosphates / Q000633:toxicity*; D009943:Organophosphorus Compounds / Q000633:toxicity*
D004270:DNA, Circular; D009153:Mutagens; D009838:Oligodeoxyribonucleotides; D010755:Organophosphates; D009943:Organophosphorus Compounds
Mutagennye svoĭstva fosfotriéfirnykh analogov oligodezoksiribonukleidov.