Morphological changes after acetylcholinesterase (AChE) inhibition by dichlorvos (DDVP) in young rabbit brain.
The present study is concerned with the lesions of nerve- and glial cells after AChE inhibition during brain development. The investigations were performed on rabbits. Dichlorvos (DDVP) an known inhibitor of AChE was given to young animals per os (4-8 mg/kg of body weight) from 6th to 15th day of life. Cerebral and cerebellar cortex and corpus callosum were examined in electron microscope. Our investigations revealed pathological changes in all neuroectodermal elements. It seems that inhibition of AChE induced by DDVP intoxication led to damage of biologic membranes. This is particularly harmful for differentiating and maturing cells.
Dambska
M
M
Laboratory of Developmental Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warsaw.
Maślińska
D
D
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D002525:Cerebellar Cortex / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D003337:Corpus Callosum / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D004006:Dichlorvos / Q000633:toxicity*; D008854:Microscopy, Electron; D010575:Pesticides / Q000633:toxicity*; D011817:Rabbits
D010575:Pesticides; D004006:Dichlorvos; D000110:Acetylcholinesterase