[The ambiguous nature of the action of m-cholinolytics in chlorophos poisoning].
The comparative study revealed significant differences in the effects of antimuscarinics on the outcome of intoxication in animals induced by direct and indirect cholinomimetics. The doses of the agents possessing equal choline blocking activity provide different levels of protection at chlorophos-induced intoxication of animals that is not observed at carbacholine-induced intoxication. The differences in the effects of direct and indirect cholinomimetics were used for the elaboration of the methodical approach that made it possible to formulate a hypothesis about the ambivalent character of the action of antimuscarinics. The hypothesis implies that the protective activity of the agents at intoxication by organophosphorus compounds is determined by the ratio of their effects on pre- and postsynaptic cholinoreceptors.
Kosmachev
A B
AB
Kosmacheva
I M
IM
Chigareva
S M
SM
D000818:Animals; D000931:Antidotes; D002217:Carbachol / Q000506:poisoning; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D051379:Mice; D010276:Parasympatholytics / Q000627:therapeutic use*; D011950:Receptors, Cholinergic / Q000187:drug effects; D014236:Trichlorfon / Q000506:poisoning*
D000931:Antidotes; D010276:Parasympatholytics; D011950:Receptors, Cholinergic; D002217:Carbachol; D014236:Trichlorfon
Dvoĭstvennyĭ kharakter deĭstviia m-kholinolitikov pri otravlenii khlorofosom.