Lysobactin, a novel antibacterial agent produced by Lysobacter sp. II. Biological properties.
Lysobactin, an antibiotic isolated from a strain of Lysobacter, is 2 to 4-fold more active than vancomycin against aerobic and anaerobic Gram-positive bacteria. Included in the spectrum of lysobactin are Staphylococci, Streptococci, corynebacteria, clostridia and various other Gram-positive anaerobic bacteria. The activity of lysobactin against aerobic and anaerobic Gram-negative bacteria is poor. When given parenterally the compound was efficacious in systemic staphylococcal and streptococcal infections in mice. Similarly, when applied topically lysobactin was also curative in a staphylococcal wound infection in mice. Some studies on the mode of action of lysobactin are presented.
Bonner
D P
DP
Squibb Institute for Medical Research, Princeton, New Jersey 08543-4000.
O'Sullivan
J
J
Tanaka
S K
SK
Clark
J M
JM
Whitney
R R
RR
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001424:Bacterial Infections / Q000188:drug therapy; D002473:Cell Wall / Q000187:drug effects; D047630:Depsipeptides; D051379:Mice; D008826:Microbial Sensitivity Tests; D009842:Oligopeptides / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D009842:Oligopeptides; D014640:Vancomycin; C056790:katanosin B