Albendazole treatment of human cystic echinococcosis.
The effect of albendazole was investigated in 20 patients with single or multiorgan hydatid cyst disease. Albendazole was used at a dose of 10 mg/kg daily in cycles of 28 d for four cycles with 15 d between cycles. Follow-up ranged from 12-18 months. Response varied according to the organ involved, the most successful results being with liver and peritoneal cysts. A positive response was seen in 47% of 34 cyst sites and a partial response was seen in a further 38% of sites. Overall response was classed as completely successful in 30% of patients, and partially successful in 60% at the end of follow-up. Adverse events were rare, although occasional abnormalities of liver function were seen.
Todorov
T
T
Institute of Pharmacology, Medical Academy, Sofia, Bulgaria.
Vutova
K
K
Petkov
D
D
Mechkov
G
G
Kolev
K
K
D000328:Adult; D015766:Albendazole; D000871:Anthelmintics / Q000008:administration & dosage* / Q000627:therapeutic use; D001562:Benzimidazoles / Q000008:administration & dosage* / Q000627:therapeutic use; D004443:Echinococcosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004444:Echinococcosis, Hepatic / Q000000981:diagnostic imaging / Q000188:drug therapy; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
D000871:Anthelmintics; D001562:Benzimidazoles; D015766:Albendazole