Amphiphilic polyphosphazenes as membrane materials: influence of side group on radiation cross-linking.
The amphiphilic mixed-substituent polyphosphazenes, [NP(OCH2CF3)x (NHCH3)y)]n and [NP(OC6H5)x (NHCH3)y]n, have been prepared by the sequential replacement of chlorine in [NPCI2]n by trifluorethoxide or phenoxide and methylamine. Thin films of these species were cross-linked by exposure to gamma radiation and the semipermeability of the resultant membranes was monitored. The radiation-induced cross-linking and membrane-forming properties of these polymers were compared with those of the single substituent polymers, [NP(OCH2CF3)2]n, [NP(OC6H5)2]n, and [NP(NHCH3)2]n. The radiation-cross-linking and appeared to involve free radical reactions at the methyl groups of the methylamino substituents. The possible utility of these materials in biomedical research is discussed.
Allcock
H R
HR
Department of Chemistry, Pennsylvania State University, University Park 16802.
Gebura
M
M
Kwon
S
S
Neenan
T X
TX
D001672:Biocompatible Materials; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008567:Membranes, Artificial; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000528:radiation effects*; D010539:Permeability; D011108:Polymers / Q000138:chemical synthesis / Q000528:radiation effects*; D012995:Solubility
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D009943:Organophosphorus Compounds; D011108:Polymers