EBM/11 reactivity in malignant histiocytosis.
A patient presented initially with a testicular mass, which on biopsy had morphological features consistent with malignant histiocytosis. The tumour cells labelled strongly with EBM/11, a murine monoclonal antibody with high specificity for cells of the human mononuclear phagocyte system. Subsequent clinical and laboratory studies confirmed the diagnosis. As poorly differentiated tumour cells reacted with EBM/11, this antibody may be useful in positively identifying malignant tumours with histiocytic differentiation from malignancies of other types where morphological detail alone is inconclusive in tumour classification.
Kelly
P M
PM
University of Oxford, Nuffield Department of Pathology, John Radcliffe Hospital.
McGovern
M
M
Gatter
K C
KC
Theaker
J M
JM
McGee
J O
JO
D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity; D001853:Bone Marrow / Q000473:pathology; D054747:Histiocytic Sarcoma / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008297:Male; D009000:Monocytes / Q000276:immunology*; D013736:Testicular Neoplasms / Q000276:immunology / Q000473:pathology
D000911:Antibodies, Monoclonal