title: Prediction of consanguinity using human DNA fingerprints.
abstract: DNA fingerprinting was performed to verify the pedigree structure of a family under investigation for an unusual case of beta thalassaemia. A higher than expected proportion of hypervariable bands was shared by the proband and his mother, leading to suspicion that the child had been the product of a consanguineous mating. Further analysis of the mother's brother showed that he was almost certainly the proband's father.
authors.affiliation: MRC Molecular Haematology Unit, John Radcliffe Hospital, Oxford.
authors.forename: R A
authors.initials: RA
authors.lastname: Wells
authors.forename: B
authors.initials: B
authors.lastname: Wonke
authors.forename: S L
authors.initials: SL
authors.lastname: Thein
mesh_terms: D002675:Child, Preschool; D002884:Chromosomes, Human, Pair 15; D002890:Chromosomes, Human, Pair 20; D003241:Consanguinity; D004247:DNA / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D010375:Pedigree; D013789:Thalassemia / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D004247:DNA