title: [Effect of nifedipine on renal activity].
abstract: Sublingual administration of nifedipine (N) at a dose of 20 mg to 8 persons without cardiovascular and renal pathology and to 19 patients with congestive heart failure (CHF) increased renal excretion of sodium (by an average of 51.1-132.8%), water (by an average of 31.7-101.9%), potassium (by an average of 43.2-63.2%) and calcium (by an average of 118%). The natriuretic effect of N appeared in 20 min reaching its maximum in 45-60 min, being more noticeable in CHF. An increment of natriuresis resulted from a decrease in sodium tubular reabsorption (correlation factor--0.92) rather than from an increase in glomerular filtration (correlation factor +0.50). N suppressed sodium reabsorption in the proximal tubule (by an average of 34.1%) as well as in the segment, more distal of Henle's loop (by an average of 6.8%). N might suppress directly calcium-dependent mechanisms of sodium transtubular transport but it could also produce a mediated effect as a result of shifts of renal hemodynamics.
authors.forename: A K
authors.initials: AK
authors.lastname: Merzon
authors.forename: T V
authors.initials: TV
authors.lastname: Donskova
authors.forename: N A
authors.initials: NA
authors.lastname: Zolotov
authors.forename: V V
authors.initials: VV
authors.lastname: Kolomiets
authors.forename: K A
authors.initials: KA
authors.lastname: Merzon
mesh_terms: D004231:Diuresis / Q000187:drug effects; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D009543:Nifedipine / Q000627:therapeutic use*; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D009543:Nifedipine
vernacular_title: Vliianie nifedipina na deiatel'nost' pochek.