title: [Clinico-immunologic characteristics of acute toxic-allergic reactions to drugs and current methods for their treatment].
abstract: The paper is concerned with clinicoimmunological and allergological characterization of 29 cases of acute toxic allergic reactions (ATAR) to drugs. Four degrees of severity of disease were identified; the most severe form was toxic epidermal necrolysis caused by the use of sulfanilamides and pyrazolones in patients with acute respiratory virus and bacterial infections. Blood analysis in patients with III-IV degree of severity showed a sharp decrease in Ctot and C3 up to 0, an increase in the level of circulating immunocomplexes and "average molecules". Cellular immunity in III degree of severity was decreased. The main principles of therapy using extracorporeal immunocorrective methods were worked out. A leukocyte natural migration inhibition test was used for specific diagnosis of intolerance to medication.
authors.forename: T V
authors.initials: TV
authors.lastname: Latysheva
authors.forename: I S
authors.initials: IS
authors.lastname: Gushchin
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Poroshina
authors.forename: V P
authors.initials: VP
authors.lastname: Leskov
authors.forename: N S
authors.initials: NS
authors.lastname: Prozorovskiĭ
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D003131:Combined Modality Therapy; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D013997:Time Factors
vernacular_title: Kliniko-immunologicheskaia kharakteristika ostrykh toksiko-allergicheskikh reaktsiĭ na medikamenty i sovremennye metody ikh lecheniia.