Induction of erosive arthritis in mice after passive transfer of anti-type II collagen antibodies.
The passive transfer of concentrated immunoglobulins or affinity-purified anti-collagen antibodies from sera of mice with type II collagen-induced arthritis can induce erosive arthritis in recipient animals. In both cases, the incidence of arthritis was over 60% and the inflammation persisted for at least two weeks. Radiography revealed bone destruction and apposition of a newly formed material while histologic examination showed cartilage and bone degradation, accompanied with synovitis and periarthritis. Inflammatory infiltrates were composed of polymorphonuclear leucocytes and lymphocytes, and were associated with a proliferation of connective tissue cells.
Loutis
N
N
Department of Inflammation Research, Ciba-Geigy Limited, Basel/Switzerland.
Bruckner
P
P
Pataki
A
A
D000818:Animals; D000906:Antibodies / Q000032:analysis / Q000276:immunology*; D001168:Arthritis / Q000276:immunology*; D003094:Collagen / Q000276:immunology*; D005552:Forelimb; D006614:Hindlimb; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology*; D007596:Joints / Q000473:pathology; D051379:Mice
D000906:Antibodies; D007074:Immunoglobulin G; D003094:Collagen