title: Radiation-induced changes in mouse duodenal papilla.
abstract: Radiation-induced changes in duodenal mucosal morphology as seen by scanning electron microscopy have been widely reported in the literature. However, no comment has previously been made on any post-irradiation alteration in the duodenal papilla. This paper describes the preliminary results of an investigation into the effects of X rays on the papilla. The duodenal papilla was difficult to find in untreated and sham irradiated mice. It was identified in only two of six mice examined and was located 5.37 and 4.43 mm from the gastroduodenal junction. Eighteen hours after irradiation with 15 Gy X rays, there was little change in position or prominence of the papilla. However, 3 days after treatment, the papilla was only 2.19-3.83 mm from the pylorus. It was also more prominent, being found in all three animals studied and having a widely dilated orifice in contrast to the closed structure seen in the unirradiated specimens. It is concluded that treatment with X rays alters the structure of the duodenal papilla. There may be implications for duodenal function in this marked change in the papilla, which controls the flow of pancreatic and biliary secretions.
authors.affiliation: Department of Anatomy, Queen's University of Belfast.
authors.forename: M
authors.initials: M
authors.lastname: Indran
authors.forename: K E
authors.initials: KE
authors.lastname: Carr
authors.forename: F C
authors.initials: FC
authors.lastname: Boyle
mesh_terms: D014670:Ampulla of Vater / Q000528:radiation effects / Q000648:ultrastructure*; D000818:Animals; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008855:Microscopy, Electron, Scanning; D011833:Radiation Injuries, Experimental / Q000473:pathology*