Influence of dopaminergic receptor supersensitivity on anticonvulsant action of carbamazepine.
Dopamine (DA) receptor supersensitivity was induced in albino rats by haloperidol (5 mg/kg, ip day, for 18 days) and after 48 hr carbamazepine (CBZ) was administered in graded doses. The animals were subjected to Maximal Electroshock Seizures (MES) test, Minimal Electroconvulsive Threshold (MET) test and Pentylenetetrazole (PTZ)-induced convulsions test. Haloperidol pretreatment marginally increased the effect of CBZ against PTZ induced seizures, but not against electrically induced seizures (MES and MET tests).
Kadlimatti
S H
SH
Department of Pharmacology, St. John's Medical College, Bangalore.
Nadig
R S
RS
Somaja
L
L
Joseph
T
T
David
J
J
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002220:Carbamazepine / Q000494:pharmacology*; D004597:Electroshock; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology; D012640:Seizures / Q000209:etiology / Q000517:prevention & control
D000927:Anticonvulsants; D011954:Receptors, Dopamine; D002220:Carbamazepine; D006220:Haloperidol; D010433:Pentylenetetrazole