Identification of 3-oxodicarboxylic acids in human urine.
Gas chromatography-mass spectrometry has been used to detect a series of 3-oxodicarboxylic acids in human urine as their corresponding dimethyl ester trimethylsilyl enol ethers. 3-Oxohexanedioic acid, 3-oxooctanedioic acid and 3-oxodecanedioic acid were demonstrated to be normal urine constituents. Increased amounts of these acids were excreted after ingestion of decanedioic acid. These findings support the hypothesis that dicarboxylic acids are degraded by ordinary beta-oxidation.
Svendsen
J S
JS
Institute of Mathematical and Physical Sciences, University of Tromsø, Norway.
Sydnes
L K
LK
Whist
J E
JE
D000328:Adult; D003998:Dicarboxylic Acids / Q000652:urine*; D004032:Diet; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007651:Keto Acids / Q000652:urine*; D008297:Male; D010084:Oxidation-Reduction; D012015:Reference Standards; D013055:Spectrophotometry, Infrared
D003998:Dicarboxylic Acids; D007651:Keto Acids