[New analgesically-active N'-acylated phenylpiperazines].
Synthesis and pharmacodynamic properties of new analgesic active N'-acylated phenylpiperazines are described. 1-(3-Cyclohexyl-1-oxo-propyl)-4-(2-ethoxyphenyl)-piperazine (D 16 120) possesses strong non-opiate antinociceptive activity showing high therapeutic margin with respect to undesired side effects and toxicity.
Oepen
G
G
Forschung der Asta Pharma AG, Frankfurt/Main.
Bork
A
A
Jakovlev
V
V
Nickel
B
B
Thiemer
K
K
Engel
J
J
D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats
D000700:Analgesics; D010879:Piperazines; C031503:phenylpiperazine
Neue analgetisch wirksame N'-acylierte Phenylpiperazine.