Functional angiotensin receptor on cultured bovine chromaffin cells: secretory response to angiotensin II and angiotensin III.
The adrenal medulla responds in vivo to exogenous angiotensin II by secreting catecholamines. We previously reported that an angiotensin receptor is present on cultured bovine chromaffin cells and mediates secretion of adrenal catecholamines. The present report examines whether the bovine chromaffin cell receptor responds to angiotensin III. We show in this report that angiotensin III is nearly equiactive with angiotensin II as a secretagogue in these cultured cells.
Brust
I
I
Department of Pharmacology, University of California, San Diego, La Jolla 92093.
Printz
M P
MP
D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000805:Angiotensin III / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D002478:Cells, Cultured; D002838:Chromaffin System / Q000166:cytology / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D011945:Receptors, Angiotensin / Q000187:drug effects*
D011945:Receptors, Angiotensin; D000804:Angiotensin II; D000805:Angiotensin III; D009638:Norepinephrine