title: Xeroderma pigmentosum with versive seizures.
abstract: A boy with group A xeroderma pigmentosum and a series of progressive neurologic complications developed versive seizures at 8 years of age. Electroencephalography at 6 years of age revealed no epileptic changes or focal abnormalities. He was seizure-free until versive seizures developed; electroencephalography revealed frequent spike discharges in the right central and temporal regions. Neurologic complications and electroencephalographic abnormalities of 34 patients with group A xeroderma pigmentosum also were assessed. Only 3 patients with xeroderma pigmentosum have been reported to have a seizure disorder. This patient is the fourth reported with group A xeroderma pigmentosum associated with a convulsive disorder. Although neurologic manifestations in group A xeroderma pigmentosum are progressive and severe, it is unknown why so few of these patients develop seizure disorders.
authors.affiliation: Department of Pediatrics, Osaka University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mimaki
authors.forename: N
authors.initials: N
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Tagawa
authors.forename: H
authors.initials: H
authors.lastname: Yabuuchi
mesh_terms: D001921:Brain / Q000503:physiopathology; D002648:Child; D004569:Electroencephalography; D006801:Humans; D008297:Male; D012640:Seizures / Q000209:etiology* / Q000503:physiopathology; D014983:Xeroderma Pigmentosum / Q000150:complications* / Q000503:physiopathology