Excretion of tiapamil in breast milk.
The excretion of tiapamil in breast milk was studied in six lactating mothers (3-7 days post partum) following a single oral 600 mg dose of the drug. The milk/plasma ratio of tiapamil derived from the areas under the plasma and milk concentration-time curves was 0.44 +/- 0.10 mean +/- s.d.). Assuming an intake of 350 ml of milk during a dosing interval of 12 h, the newborn would be exposed at the maximum to 0.053 mg tiapamil. This small amount does not represent a risk for the baby.
Hartmann
D
D
Pharma Clinical Research, F. Hoffmann-La Roche & Co. Ltd, Basle, Switzerland.
Lunell
N O
NO
Friedrich
G
G
Rane
A
A
D000328:Adult; D002121:Calcium Channel Blockers / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D006801:Humans; D008895:Milk, Human / Q000378:metabolism*; D011437:Propylamines / Q000097:blood / Q000493:pharmacokinetics*; D013976:Tiapamil Hydrochloride
D002121:Calcium Channel Blockers; D011437:Propylamines; D013976:Tiapamil Hydrochloride