title: [Effect of human milk enzymes on carbohydrate metabolism during adaptation of newborn infants in the early neonatal period].
abstract: The total activity and isoenzymatic composition of lactic dehydrogenase (LDG), malic dehydrogenase (MDG) and glucose 6-phosphate dehydrogenase (G-6-PDG) were studied in the blood serum and erythrocytes of 56 premature and 18 mature newborns, as well as in colostrum and mature breast milk. The growth of the role of anaerobic glycolysis was observed at the end of the neonatal period in the mature newborns. In highly premature newborns the activity of glycolysis and pentose cycle of glucose oxidation was especially high. Isozymic spectrum of LDG evidences the prevalence of the processes of aerobic glycolysis in the premature which is unfavourable under conditions of hypoxia. The pattern of changes in the MDG spectrum denotes a low activity of reactions of the tricarboxylic acid cycle. Isoenzymatic composition of colostrum and milk is close to that in the newborn's blood. Enzymes of colostrum and milk influence carbohydrate metabolism thus producing favourable effect on the adaptation processes in the newborns.
authors.forename: T K
authors.initials: TK
authors.lastname: Nabukhotnyĭ
authors.forename: V E
authors.initials: VE
authors.lastname: Markevich
authors.forename: V P
authors.initials: VP
authors.lastname: Pavliuk
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Tkachenko
mesh_terms: D000222:Adaptation, Physiological; D000367:Age Factors; D003126:Colostrum / Q000201:enzymology; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006019:Glycolysis; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008291:Malate Dehydrogenase / Q000378:metabolism*; D008895:Milk, Human / Q000201:enzymology*; D011247:Pregnancy
chemical_list: D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase
vernacular_title: Vliianie fermentov grudnogo moloka na metabolizm uglevodov v protsesse adaptatsii novorozhdennykh v rannem neonatal'nom periode.