1,2,3-Triazoles: structural changes on two effective inhibitors of the prostaglandin synthesis in vitro.
This paper describes the synthesis and the biological evaluation of some 1,2,3-triazoles which represent structural modifications of two compounds which are effective inhibitors of the prostaglandin synthesis in vitro. These modifications, concerning the elimination of the methylene bridge and/or the ether oxygen from the active molecules, show that every introduced structural changes caused a strong decrease of activity.
Biagi
G
G
Istituto di Chimica Farmaceutica, Università di Pisa, Italy.
Livi
O
O
Scartoni
V
V
Verugi
E
E
D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008315:Malondialdehyde / Q000097:blood; D011448:Prostaglandin Antagonists / Q000138:chemical synthesis*; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D011448:Prostaglandin Antagonists; D014230:Triazoles; D008315:Malondialdehyde