Effect of neonatal monosodium-L-glutamate treatment on the response of isolated uterine preparation to various uterine contraction stimulators.
1. The uterine activity of rats treated neonatally with MSG was examined in vitro by measuring the contractile response of the tissue to hormone/chemical stimulation. 2. The uterine responses to ACh and ANG II remained unchanged following neonatal MSG treatment while those to PGF2 alpha were sensitized. 3. The responses to OT and 5-HT were characterized by a reduction of the maximal contractile force and the rate of change in tension increased and decreased compared with the control with OT and 5-HT respectively. 4. Data suggested that these changes on uterine contractility could be ascribed to various possible mechanisms of action of MSG.
Wong
C C
CC
Department of Physiology, Chinese University of Hong Kong, Shatin, N.T.
Chu
J Y
JY
Chiu
K W
KW
D000109:Acetylcholine / Q000494:pharmacology; D000420:Albuterol / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D015237:Dinoprost / Q000494:pharmacology; D005260:Female; D005971:Glutamates / Q000633:toxicity*; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012970:Sodium Glutamate / Q000633:toxicity*; D014590:Uterine Contraction / Q000187:drug effects*
D005971:Glutamates; D000804:Angiotensin II; D015237:Dinoprost; D000109:Acetylcholine; D000420:Albuterol; D012970:Sodium Glutamate