Electrophysiological effects of the new cardioactive drug CERM 4205: a comparative study in an animal model and in man.
The cardiac electrophysiological effects of CERM 4205, a new cardioactive agent, were studied by means of intracardiac electrodes in man and in anaesthetized dogs. The results show that CERM 4205 is a cardioactive drug with a main inhibitory effect on slow-response structures (sinus and atrioventricular node) with an associated effect on fast-response structures (atrial, His-Purkinje and ventricular tissues). No qualitative differences were observed between the effects observed in man and dogs. In conclusion, the present study confirms that CERM 4205 is a compound with combined class IV and class I electrophysiological effects in dogs and man. The anaesthetized dog appears to be a satisfactory model for the evaluation of the electrophysiological effects of cardioactive drugs.
Brugada
J
J
Institute of Biology, Faculty of Medicine, University of Montpellier, France.
Lamar
J C
JC
Boisson
P
P
Masse
C
C
Puech
P
P
Sassine
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002036:Bundle of His / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D003511:Cyclohexanols / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D011690:Purkinje Fibers / Q000378:metabolism; D011759:Pyrrolidines / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D012849:Sinoatrial Node / Q000378:metabolism
D002121:Calcium Channel Blockers; D003511:Cyclohexanols; D011759:Pyrrolidines; C058567:4205CERM