title: Retrograde cochlear neuronal degeneration in human subjects.
abstract: The purpose of this study was to identify the structural changes in the organ of Corti that correlate with retrograde cochlear neuronal degeneration. Thirty-eight temporal bones with excellent histological preparation from 23 subjects having hearing losses caused by cochlear disease were selected for study. Cytohistograms were prepared for inner and outer hair cells, inner and outer pillar cells, inner phalangeal cells, and cochlear neurons. The extent of neuronal degeneration was found to be directly related to the extent of injury to inner pillar cells and inner phalangeal cells, but not to loss of inner or outer hair cells. In most cochleas the loss of dendritic nerve fibers exceeded the loss of cell bodies. The findings support the concept that retrograde neuronal degeneration is initiated by injury to the dendritic nerve fibers, secondary to collapse and/or degeneration of the inner pillar cells and inner phalangeal cells.
authors.affiliation: Massachusetts Eye and Ear Infirmary, Boston.
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuka
authors.forename: H F
authors.initials: HF
authors.lastname: Schuknecht
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D005260:Female; D006198:Hair Cells, Auditory / Q000648:ultrastructure; D006317:Hearing Loss, Noise-Induced / Q000473:pathology*; D006319:Hearing Loss, Sensorineural / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009410:Nerve Degeneration; D009925:Organ of Corti / Q000473:pathology*; D014777:Virus Diseases / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents