title: Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects.
abstract: Thirteen subjects between the ages of 50 years and 70 years were administered a daily 25,000 IU dose of retinol for 9 months. Two subjects experienced mild skin dryness, headaches, and/or alopecia. There were no significant changes in serum chemistries. High performance liquid chromatography assays for plasma retinol revealed no evidence of drug accumulation; however, there was a significant increase in the plasma concentration-versus-time curve for retinyl palmitate concentrations between the first and subsequent sampling days (P = 0.009). The mean skin retinol and retinyl palmitate concentrations in 7 retinol-treated subjects (131.7 and 15.9 ng/g, respectively) were not significantly different from those observed in 13 age-matched controls (118.9 and 25.5 ng/gm, respectively).
authors.affiliation: Department of Medicine, University of Arizona College of Medicine, Tucson.
authors.forename: D S
authors.initials: DS
authors.lastname: Alberts
authors.forename: L
authors.initials: L
authors.lastname: McDonald
authors.forename: L
authors.initials: L
authors.lastname: Edwards
authors.forename: Y M
authors.initials: YM
authors.lastname: Peng
authors.forename: M J
authors.initials: MJ
authors.lastname: Xu
authors.forename: D J
authors.initials: DJ
authors.lastname: Slymen
authors.forename: D L
authors.initials: DL
authors.lastname: Earnest
authors.forename: C
authors.initials: C
authors.lastname: Ritenbaugh
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000368:Aged; D000970:Antineoplastic Agents / Q000633:toxicity; D004224:Diterpenes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000084562:Retinyl Esters; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D014018:Tissue Distribution; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate