title: Determination of methyl ethyl ketone and its metabolites in urine using capillary gas chromatography.
abstract: A method is described for the determination of the concentration of methyl ethyl ketone and its metabolites: 2-butanol, 3-hydroxy-2-butanone and the meso- and d,l-isomers of 2,3-butanediol in urine. The analytes were isolated from urine by solid-phase extraction and analysed by capillary gas chromatography. The recovery rates were 50-70% for the 2,3-butanediol isomers and 88-96% for the other analytes. The precision of the method ranged from 5 to 12% (S.D.%). The detection limit was 1.0 and 1.4 mg/l for meso- and d,l-2,3-butanediol, respectively, and ranged from 0.1 to 0.15 mg/l for the other analytes.
authors.affiliation: Coronel Laboratory for Occupational and Environmental Health, University of Amsterdam, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Kezić
authors.forename: A C
authors.initials: AC
authors.lastname: Monster
mesh_terms: D002074:Butanones / Q000652:urine*; D002849:Chromatography, Gas; D006801:Humans; D007202:Indicators and Reagents; D009784:Occupational Diseases / Q000652:urine
chemical_list: D002074:Butanones; D007202:Indicators and Reagents; C005222:methylethyl ketone