title: A comparative study of the permeation of dihexadecyl phosphate vesicles by various carboxylic acids and some of their tetrazole analogues.
abstract: The evaluation of the effect that perturbers may have on a membrane model is described. The model was made from dihexadecyl phosphate bilayers. The perturbers used were carboxylic acids and some of their tetrazole analogues. The results show a good correlation between the permeation properties of the carboxylic acids and tetrazole analogues. Moreover, this study reveals that membrane-perturbing effects are mainly under the control of conformational parameters and dependent on the carbon chain length of the permeants.
authors.affiliation: Département de Chimie, Faculté des Sciences de Luminy, Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Pernice
authors.forename: M
authors.initials: M
authors.lastname: Castaing
authors.forename: P
authors.initials: P
authors.lastname: Ménassa
authors.forename: J L
authors.initials: JL
authors.lastname: Kraus
mesh_terms: D001393:Azoles; D002264:Carboxylic Acids; D008567:Membranes, Artificial; D008954:Models, Biological; D008968:Molecular Conformation; D010755:Organophosphates; D009943:Organophosphorus Compounds; D013329:Structure-Activity Relationship; D013777:Tetrazoles
chemical_list: D001393:Azoles; D002264:Carboxylic Acids; D008567:Membranes, Artificial; D010755:Organophosphates; D009943:Organophosphorus Compounds; D013777:Tetrazoles; C002290:dicetylphosphate