A monoclonal antibody recognizing a common antigen on neurons and fibroblasts in chicken and quail.
A monoclonal antibody, FiN1, obtained by immunization of a mouse with homogenates of embryonic quail nodose ganglia, was found to react with a surface antigenic determinant, both in quail and chick, present on practically all neurons of the spinal cord and of the peripheral nervous system and on a subpopulation of fibroblasts. An ontogenetic study performed on tissue sections, cell suspensions and cultures showed that FiN1 defines a differentiation marker which appears relatively late in development, during the second half of embryonic life, and persists after hatching. The onset and evolution of its expression during development varies in a tissue-specific manner.
Graniou
M
M
Institut d'Embryologie du CNRS et du Collège de France, Nogent-sur-Marne.
Chanconie
M
M
Ziller
C
C
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000941:Antigens / Q000276:immunology*; D000943:Antigens, Differentiation / Q000276:immunology; D002645:Chickens; D003370:Coturnix; D005347:Fibroblasts / Q000276:immunology*; D009474:Neurons / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
D000911:Antibodies, Monoclonal; D000941:Antigens; D000943:Antigens, Differentiation