Structural and immunological relationship between laminin and the cysteine proteinase inhibitor stefin.
A sequence analogy was found between the C-terminal region of the B1 chain of laminin (residues 1538-1639) and cysteine proteinase inhibitors, in particular the stefin group. The sequence analogous with cysteine proteinase inhibitors occurs in fragment E8 obtained by elastase digestion of laminin. Antibodies raised against E 8 reacted with stefin but not with kininogen or cystatin.
Keil-Dlouha
V
V
Unité de Chimie des Protéines, Institut Pasteur, Paris, France.
Paulsson
M
M
Joukoff
E
E
Lenarcic
B
B
Turk
V
V
D000595:Amino Acid Sequence; D000818:Animals; D000936:Antigen-Antibody Complex; D055313:Cystatin B; D015891:Cystatins; D004797:Enzyme-Linked Immunosorbent Assay; D007106:Immune Sera; D007797:Laminin / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D011480:Protease Inhibitors; D011506:Proteins / Q000276:immunology
D000936:Antigen-Antibody Complex; C524992:Cstb protein, mouse; D015891:Cystatins; D007106:Immune Sera; D007797:Laminin; D011480:Protease Inhibitors; D011506:Proteins; D055313:Cystatin B