title: [A case of hypercalcemia with ovarian carcinoma].
abstract: A 45-year-old female manifested lower abdominal fullness and symptoms of hypercalcemia with nausea, vomiting, and thirst. Physical examination showed a right ovarian mass and laboratory data demonstrated hypercalcemia (14.6 mg/dl). The radiographic findings confirmed a right ovarian tumor without any evidence of bone metastasis. Tests revealed that her PTH, nephrogenic urinary cyclic AMP, and 1-25 (OH)2 Vitamin D were not high but that her prostaglandin E2 (PGE2) was elevated. After correction of her calcium elevation with infusion and prednisolone, right oophorectomy with tumor excision was performed. A histological examination of the tumor revealed a mucinous cysto-adenocarcinoma. The postoperative course has been uneventful, with normal calcium and PGE2 values. This case illustrates that hypercalcemia associated with an ovarian carcinoma (Malignancy-associated hypercalcemia) can be mediated by the patient's PGE2 in part.
authors.affiliation: Dept. of Intern. Med., Kakogawa Municipal Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Miura
authors.forename: M
authors.initials: M
authors.lastname: Hashiramoto
authors.forename: K
authors.initials: K
authors.lastname: Matsuda
authors.forename: O
authors.initials: O
authors.lastname: Nakano
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Maeda
authors.forename: K
authors.initials: K
authors.lastname: Okada
authors.forename: T
authors.initials: T
authors.lastname: Chinzei
authors.forename: K
authors.initials: K
authors.lastname: Yamashiro
authors.forename: M
authors.initials: M
authors.lastname: Harui
mesh_terms: D003131:Combined Modality Therapy; D003536:Cystadenocarcinoma / Q000097:blood / Q000150:complications* / Q000628:therapy; D015232:Dinoprostone / Q000097:blood; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications* / Q000628:therapy; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D011239:Prednisolone; D015232:Dinoprostone