title: Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol.
abstract: Catecholamines are hypothesized to control cellular development in the central nervous system. In the current study, isoproterenol administered intracisternally to neonatal rats was found to inhibit DNA synthesis [( 3H]thymidine incorporation) in brain regions. The regional selectivity of effect corresponded to the sequence of cellular maturation, namely midbrain + brainstem greater than cerebral cortex greater than cerebellum, suggesting that the specific linkage of beta-adrenergic receptors to cessation of cell replication occurs during a specific maturational stage.
authors.affiliation: Department of Pharmacology, Duke University Medical Center, Durham, NC 27710.
authors.forename: T A
authors.initials: TA
authors.lastname: Slotkin
authors.forename: R
authors.initials: R
authors.lastname: Windh
authors.forename: W L
authors.initials: WL
authors.lastname: Whitmore
authors.forename: F J
authors.initials: FJ
authors.lastname: Seidler
mesh_terms: D000320:Adrenergic Fibers / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine
chemical_list: D007545:Isoproterenol; D013936:Thymidine