Assessment of cognitive function in elderly patients treated with naproxen. A prospective study.
Cognitive functions were assessed in 12 elderly patients prior to and following a three-week therapeutic course of Naproxen, 750 mg/day. Four of the patients deteriorated in one of the four cognitive tests, one of these patients in two tests. However, none of these changes reached statistical significance. Although non-steroidal anti-inflammatory drugs can cause some cognitive alteration in the elderly, this change is mild, and its clinical meaning questioned.
Wysenbeek
A J
AJ
Department of Internal Medicine B, Beilinson Medical Center, Petah Tiqva, Israel.
Klein
Z
Z
Nakar
S
S
Mane
R
R
D000368:Aged; D003072:Cognition Disorders / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D009288:Naproxen / Q000009:adverse effects*; D010003:Osteoarthritis / Q000188:drug therapy; D011446:Prospective Studies
D009288:Naproxen