title: [Clinical picture and possible causes of functional disorders of the parotid gland in radioiodine therapy of differentiated thyroid cancer].
abstract: The parotid gland function was examined in 31 patients with thyroid carcinoma treated with radio-iodine. Beside enhanced values of sodium concentration, protein concentration and alpha-amylase activity following each therapy, a continuous reduction of flow rate and alpha-amylase activity is found according to the cumulative total dose. The importance of glandular kallikrein und phosphohexoseisomerase (PHI) are discussed with regard to their possible role in glandular damage. A comparison is made with chronic recurrent parotitis, and therapeutical aspects are considered. On the whole the present investigation shows that radio-iodine therapy causes damage to the parotid gland, which normally leads to measurable effects after cumulative doses of 470 mCi.
authors.affiliation: Universitäts-Hals-Nasen-Ohrenklinik Heidelberg.
authors.forename: M
authors.initials: M
authors.lastname: Deeg
authors.forename: H
authors.initials: H
authors.lastname: Maier
authors.forename: H
authors.initials: H
authors.lastname: Bihl
authors.forename: D
authors.initials: D
authors.lastname: Adler
mesh_terms: D003131:Combined Modality Therapy; D005956:Glucose-6-Phosphate Isomerase / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007610:Kallikreins / Q000378:metabolism; D010306:Parotid Gland / Q000503:physiopathology / Q000528:radiation effects*; D011832:Radiation Injuries / Q000503:physiopathology*; D011879:Radiotherapy Dosage; D012471:Salivary Proteins and Peptides / Q000378:metabolism; D012472:Salivation / Q000528:radiation effects*; D013964:Thyroid Neoplasms / Q000532:radiotherapy*; D013965:Thyroidectomy
chemical_list: D007457:Iodine Radioisotopes; D012471:Salivary Proteins and Peptides; D007610:Kallikreins; D005956:Glucose-6-Phosphate Isomerase
vernacular_title: Klinisches Bild und mögliche Ursachen der Funktionsstörungen der Glandula parotis bei der Radiojodtherapie des differenzierten Schilddrüsenkarzinoms.