Prediction of consanguinity using human DNA fingerprints.
DNA fingerprinting was performed to verify the pedigree structure of a family under investigation for an unusual case of beta thalassaemia. A higher than expected proportion of hypervariable bands was shared by the proband and his mother, leading to suspicion that the child had been the product of a consanguineous mating. Further analysis of the mother's brother showed that he was almost certainly the proband's father.
Wells
R A
RA
MRC Molecular Haematology Unit, John Radcliffe Hospital, Oxford.
Wonke
B
B
Thein
S L
SL
D002675:Child, Preschool; D002884:Chromosomes, Human, Pair 15; D002890:Chromosomes, Human, Pair 20; D003241:Consanguinity; D004247:DNA / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D010375:Pedigree; D013789:Thalassemia / Q000235:genetics*; D014178:Translocation, Genetic
D004247:DNA