[Polyamines as a prognostic criterion of the duration of clinico-hematologic remission in acute leukemia in children].
The authors reported the results of retrospective analysis of the level of polyamines in urine and the duration of clinicohematological remission in 25 AL children aged 3 to 14. Of this number 23 patients suffered from acute lymphoblastic leukemia, 2--from acute myeloblastic leukemia. Direct correlation between polyamine changes during a course of chemotherapy and the duration of remission was established. Longer duration was observed in the patients in whom a 2-fold rise of the level of all polyamines, especially spermidine, followed the administration of a cytostatic within the first 24-72 h. On the discontinuation of therapy a certain decrease in polyamine excretion with urine was observed in these children as compared to the level determined on their admission to hospital.
Kovtunova
M E
ME
Voronchikhina
L D
LD
Riabova
T I
TI
Riabov
N V
NV
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000188:drug therapy*; D011073:Polyamines / Q000652:urine*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy*; D011237:Predictive Value of Tests; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies
D011073:Polyamines
Poliaminy kak prognosticheskiĭ kriteriĭ dlitel'nosti kliniko-gematologicheskoĭ remissii pri ostrom leĭkoze u deteĭ.