Embryotoxic and teratogenic effects of aluminum nitrate in rats upon oral administration.
In order to determine the embryotoxic and teratogenic potential of aluminum, pregnant Sprague-Dawley rats were treated by gavage with a daily dose of 180, 360, or 720 mg/kg of aluminum nitrate from the sixth through to the fourteenth day of gestation. Fetal examinations were performed on day 20. The number of corpora lutea, total implants, and resorptions as well as the number of live and dead fetuses in the treated animals were not significantly different from the control group. Therefore, embryolethality of aluminum cannot be induced (as a measure of percent dead and resorbed fetuses). However, exposure of rats to aluminum nitrate resulted in decreased fetal body weight and increased the incidence and types of external, visceral, and skeletal malformations and variations in all the treated groups. Consequently, teratogenic effects of aluminum-nitrate administration may result in rats given high oral doses that induce concomitant maternal toxicity.
Paternain
J L
JL
Laboratory of Toxicology and Biochemistry, School of Medicine, Reus, Spain.
Domingo
J L
JL
Llobet
J M
JM
Corbella
J
J
D000284:Administration, Oral; D000535:Aluminum / Q000008:administration & dosage / Q000633:toxicity*; D017607:Aluminum Compounds; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005327:Fetal Resorption / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects; D009566:Nitrates / Q000008:administration & dosage / Q000633:toxicity*; D010920:Placenta / Q000033:anatomy & histology / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013723:Teratogens
D017607:Aluminum Compounds; D009566:Nitrates; D013723:Teratogens; D000535:Aluminum; C050609:aluminum nitrate