[Decrease in the antimetastatic effect of vinblastine administered in liposomes].
The model of experimental metastases in the HA-1 tumour in the liver of A/He mice was used to show that the anti-tumoural effect of cis-dichlorodiamminoplatinum being used in the liposomes increases, while that of vinblastine (VB) decreases. It is suggested that the low activity of liposome-encapsulated VB as to its influence on the tumour growth in the liver is a result of preferable uptake of liposomes by Kupffer cells and hepatocytes from where VB cannot diffuse into tumour cells since it binds to intracellular tubulin.
Kaledin
V I
VI
Popova
N A
NA
Nikolin
V P
VP
Semenova
L A
LA
Budker
V G
VG
D000818:Animals; D004337:Drug Carriers; D008081:Liposomes; D008114:Liver Neoplasms, Experimental / Q000556:secondary; D051379:Mice; D008805:Mice, Inbred A; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D014747:Vinblastine / Q000008:administration & dosage* / Q000037:antagonists & inhibitors
D004337:Drug Carriers; D008081:Liposomes; D014747:Vinblastine
Snizhenie protivometastaticheskogo éffekta vinblastina pri ego ispol'zovanii v liposomakh.