[Effect of dimephosphon on the blood circulation and oxygen tension in the brain of normal waking rabbits and in motion sickness].
By using methods of hydrogen clearance and polarography it was shown that rocking of conscious rabbits is followed by an increase of total cerebral blood flow, local blood flow and oxygen tension (pO2) in the frontal, occipital and temporal brain cortex during hypotension and a decrease of the heart rate. Dimephosphon causes a decrease of the cerebral blood flow both during the stationary position of animals and rocking, exerting a weak influence on pO2 in the cerebral cortex, arterial blood pressure and the heart work.
Beketov
A I
AI
Skoromnyĭ
N A
NA
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003864:Depression, Chemical; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D009041:Motion Sickness / Q000188:drug therapy* / Q000503:physiopathology; D009943:Organophosphorus Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D010101:Oxygen Consumption / Q000187:drug effects*; D010313:Partial Pressure; D011817:Rabbits; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D009943:Organophosphorus Compounds; C049638:dimephosphon
Vliianie dimefosfona na krovoobrashchenie i napriazhenie kisloroda v golovnom mozge bodrstvuiushchikh krolikov v norme i pri ukachivanii.