[Modifying effect of antioxidants on the rate of lipid peroxidation in liver microsomes at early stages of diethylnitrosamine biotransformation].
Lipid peroxidation and free radicals' generation were investigated in rats treated with carcinogenic diethylnitrosamine (DENA) after pretreatment with some antioxidants. It was shown that decreased generation of free radicals during DENA metabolism in rat liver microsomes after pretreatment of animals with antioxidants may be the cause of the protective action of these antioxidants against DENA toxicity. Lipid peroxidation was shown to be not a crucial reaction in the toxic effect of DENA.
Pakhomov
V Iu
VIu
Artemova
L G
LG
Shuliakovskaia
T S
TS
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004052:Diethylnitrosamine / Q000493:pharmacokinetics* / Q000633:toxicity; D004347:Drug Interactions; D005609:Free Radicals; D007928:Lethal Dose 50; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000975:Antioxidants; D005609:Free Radicals; D004052:Diethylnitrosamine; D009249:NADP; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System
Modifitsiruiushchee vliianie antioksidantov na skorost' reaktsiĭ perekisnogo okisleniia lipidov v mikrosomakh pecheni na nachal'nykh étapakh biotransformatsii diétilnitrozaminov.