title: [Mechanism of hypotension induced by rifampicin during intravenous administration].
abstract: In vivo and in vitro experiments showed that the mechanism of hypotension induced by rifampicin was not associated with its effect on peripheral m- and n-cholinoreactive and adrenoreactive systems. It was due to the direct action of the drug on the vessel muscular wall and its mediated effect on the histaminergic systems participating in vascular tension control.
authors.forename: V V
authors.initials: VV
authors.lastname: Berezhinskaia
authors.forename: G V
authors.initials: GV
authors.lastname: Dolgova
authors.forename: T P
authors.initials: TP
authors.lastname: Svinogeeva
authors.forename: A I
authors.initials: AI
authors.lastname: Zebrev
mesh_terms: D000818:Animals; D002415:Cats; D006168:Guinea Pigs; D007022:Hypotension / Q000139:chemically induced*; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D051379:Mice; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects; D011968:Receptors, Histamine / Q000187:drug effects; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D011968:Receptors, Histamine; D012293:Rifampin
vernacular_title: K mekhanizmu gipotenii, vyzyvaemoĭ rifampitsinom pri vnutrivennom vvedenii.