title: Long-term hypoxia increases the turnover of dopamine but not norepinephrine in rat sympathetic ganglia.
abstract: The content and turnover of dopamine, 3,4-dihydroxyphenylacetic acid and norepinephrine have been investigated in the superior cervical, coeliac and mesenteric ganglia of rats exposed to moderate normobaric hypoxia (10% O2 in N2) lasting for 2-28 days. the turnover was estimated by the decrease in amine contents after inhibition of catecholamine biosynthesis with alpha-methyl-p-tyrosine. In all 3 sympathetic ganglia, long-term hypoxia elicited a sustained increase in the content and turnover of dopamine. In contrast, the content and turnover of norepinephrine remained unchanged, except for a moderate increase in the coeliac ganglion after 14 and 28 days of hypoxia. These results suggest that the dopamine and norepinephrine pools in ganglia have a different functional significance and that rat sympathetic ganglia contain a pool of dopamine specifically sensitive to long-term hypoxia.
authors.affiliation: Laboratoire de Physiologie A, Faculté de Médecine Grange-Blanche, Lyon, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Dalmaz
authors.forename: J M
authors.initials: JM
authors.lastname: Pequignot
authors.forename: E
authors.initials: E
authors.lastname: Tavitian
authors.forename: J M
authors.initials: JM
authors.lastname: Cottet-Emard
authors.forename: L
authors.initials: L
authors.lastname: Peyrin
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D002908:Chronic Disease; D004298:Dopamine / Q000378:metabolism*; D005728:Ganglia, Sympathetic / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
chemical_list: D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine; D009638:Norepinephrine