[Effect of ethacizine on indices of the oxygen regimen and blood perfusion of the skin in psoriasis patients].
Oxygen regimen and hemoperfusion of affected and visually unchanged skin were studied in 35 patients with psoriasis universalis using methods of H and O polarography. Latent disorders of the microcirculatory system detected by functional tests were noted in visually unaffected skin zones. Sharp changes of oxygen regimen and hemoperfusion indices were noted in affected skin, especially during progression of disease. Course therapy with etatsizin at a daily dose of 150 mg resulted in a positive time course of a skin process in 91% of the patients; indices of microcirculation and tissue metabolism were significantly improved.
Kurdina
M I
MI
Almazov
I I
II
Ataullakhanova
D M
DM
Svet
E A
EA
Savel'eva
S I
SI
D000328:Adult; D002908:Chronic Disease; D004341:Drug Evaluation; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects*; D010313:Partial Pressure; D010640:Phenothiazines / Q000627:therapeutic use*; D011565:Psoriasis / Q000188:drug therapy* / Q000503:physiopathology; D012867:Skin / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism
D010640:Phenothiazines; C046818:ethacizine
Vliianie étatsizina na pokazateli kislorodnogo rezhima i gemoperfuzii kozhi u bol'nykh psoriazom.