title: Erythromycin-induced immune hemolytic anemia.
abstract: A 3-year-old female receiving Pediazole (erythromycin ethylsuccinate and sulfisoxazole) for tonsillitis and otitis media developed severe hemolytic anemia. No serum drug-dependent antibodies could be demonstrated with an in vitro 'immune-complex' method using Pediazole, pure erythromycin ethylsuccinate or pure sulfisoxazole. However, a method using red cells coated with erythromycin base showed in vitro lysis of the erythromycin-coated red cells. This is only the second case of immune hemolytic anemia associated with erythromycin and the first where in vitro drug-dependent hemolysis was demonstrable.
authors.affiliation: American Red Cross Blood Services, Los Angeles-Orange Counties Region, Calif.
authors.forename: S J
authors.initials: SJ
authors.lastname: Nance
authors.forename: S
authors.initials: S
authors.lastname: Ladisch
authors.forename: T L
authors.initials: TL
authors.lastname: Williamson
authors.forename: G
authors.initials: G
authors.lastname: Garratty
mesh_terms: D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000276:immunology; D002675:Child, Preschool; D004912:Erythrocytes / Q000187:drug effects; D004917:Erythromycin / Q000009:adverse effects*; D005260:Female; D006801:Humans
chemical_list: D004917:Erythromycin