Characterization of a new kinin potentiating peptide obtained from human plasma proteins.
Partially purified kinin potentiating peptide (KPP) obtained from kininogen-depleted human plasma inhibited lung angiotensin converting enzyme in vitro and potentiated guinea-pig ileum contractions induced by bradykinin (BK), Lys-BK, Met-Lys-BK, Ile-Ser-BK, and Lys-Lys-BK. Contractions evoked by angiotensin II, histamine, acetylcholine, and barium chloride were not potentiated. KPP also potentiated kinin-induced contractions of rat uterus and of guinea-pig ileum pre-incubated with 1,10-phenanthroline. It is suggested that KPP potentiation is due, at least in part, to a direct effect on kinin receptor(s).
Assreuy-Filho
J
J
Departamento de Bioquímica, Universidade Federal do Rio de Janeiro, Brasil.
Almeida
A A
AA
Guimarães
J A
JA
D000818:Animals; D001798:Blood Proteins / Q000302:isolation & purification*; D001920:Bradykinin / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007705:Kinins / Q000302:isolation & purification* / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects
D001798:Blood Proteins; D007705:Kinins; D001920:Bradykinin