Passage of allophanoyl-gamma-lactones through the kidney.
In order to establish if allophanoyl-gamma lactones (B compounds) can pass through the kidney or if only the corresponding delta-hydroxybarbiturates (A compounds), formed by intramolecular alcoholysis, are able to do so, nine experiments were performed to study the urinary excretion of four different allophanoyl gamma-lactones B after administration to dogs. Excreted compounds were extracted, identified and quantised. From the amounts of unmodified administered lactones that were recovered, it is concluded that B compounds can pass through the kidney before isomerisation into the corresponding barbiturates A.
Lafont
O
O
Laboratoire de Chimie Organique, Centre de Pharmacochimie du Madrillet, Faculté de Médecine, Saint-Etienne de Rouvray, France.
Cave
C
C
Menager
S
S
Lambrey
B
B
Miocque
M
M
D000818:Animals; D001463:Barbiturates / Q000493:pharmacokinetics*; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D004285:Dogs; D005260:Female; D007668:Kidney / Q000378:metabolism*; D007783:Lactones / Q000378:metabolism* / Q000652:urine; D009682:Magnetic Resonance Spectroscopy; D008297:Male
D001463:Barbiturates; D007783:Lactones