The effect of maternal smoking on the relationship between maternal and fetal zinc status and infant birth weight.
We have previously reported a trapping of zinc in the placenta directly related to circulating cadmium that comes from cigarette smoke. The purpose of this study was to examine in detail the effect of smoking on (a) the relationship between maternal and fetal zinc status and (b) the relationship between zinc status and birth weight. One hundred and eighteen smokers and 172 nonsmokers without any medical complications during pregnancy were studied. Atomic absorption spectroscopy was used to assess zinc status in maternal and cord vein plasma and red blood cells. Plasma alkaline phosphatase was also determined as an index of zinc status. Thiocyanate was used as an index of smoking status. The data were analyzed using univariate correlations and repeated measures analysis of variance. Infants of smokers had a statistically significant decrease in plasma zinc (5%), alkaline phosphatase (13%), and in cord vein RBC zinc (12%). Furthermore, the results showed an altered relationship between maternal and fetal indices of zinc status and zinc status and birth weight due to maternal smoking. The infant of the nonsmoking mother appears to be able to maintain adequate zinc status due to depletion of maternal zinc. However, it appears that the infant of the smoking mother may be marginally zinc deficient. These findings support studies of zinc supplementation in the pregnancy complicated by smoking.
Kuhnert
B R
BR
Department of Obstetrics and Gynecology, Cleveland Metropolitan General Hospital, Ohio 44109.
Kuhnert
P M
PM
Lazebnik
N
N
Erhard
P
P
D000469:Alkaline Phosphatase / Q000097:blood; D001724:Birth Weight; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012907:Smoking / Q000009:adverse effects*; D013861:Thiocyanates / Q000097:blood; D015032:Zinc / Q000172:deficiency / Q000378:metabolism*
D013861:Thiocyanates; D000469:Alkaline Phosphatase; D015032:Zinc