Wound healing using a collagen matrix: effect of DC electrical stimulation.
Rapid fibroblast ingrowth and collagen deposition occurs in a reconstituted type I collagen matrix that is implanted on full-thickness excised animal dermal wounds. The purpose of this study is to evaluate the effects of direct current stimulation on dermal fibroblast ingrowth using carbon fiber electrodes incorporated into a collagen sponge matrix. Preliminary results suggest that fibroblast ingrowth and collagen fiber alignment are increased in collagen sponges stimulated with direct currents between 20 and 100 microA. Maximum fibroblast ingrowth into the collagen sponge is observed near the cathode at a current of 100 microA. These results suggest that electrical stimulation combined with a collagen matrix may be a method to enhance the healing of chronic dermal wounds.
Dunn
M G
MG
Department of Pathology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway 08854.
Doillon
C J
CJ
Berg
R A
RA
Olson
R M
RM
Silver
F H
FH
D000818:Animals; D003094:Collagen; D004195:Disease Models, Animal; D004558:Electric Stimulation; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D019736:Prostheses and Implants; D014945:Wound Healing; D014947:Wounds and Injuries / Q000473:pathology
D003094:Collagen