Pharmacokinetics of netilmicin during hemodialysis: comparison of four artificial kidneys.
The pharmacokinetics of netilmicin was studied in 11 patients with terminal renal impairment (Clcr less than 5 ml/min) during the course of a 4-h hemodialysis session, using four different kinds of dialyzer: Biospal 2400, Biospal 3000, Allegro HF, and Andante HF. All patients received a single dose of 2 mg netilmicin/kg body wt at the beginning of the dialysis session. The type of dialyzer influences the serum half-life, the dialysis clearance and the percentage of drug extracted during dialysis. A linear relationship was established between the drug fraction extracted by dialysis and the dialysis clearance of the antibiotic. During the hemodialysis sessions, the serum half-life of netilmicin decreased approximately 10-fold compared with the interdialysis periods.
Herrero
A
A
Department of Pharmacology and Pharmacotechnique, Faculty of Pharmacy, Valencia, Spain.
Rius Alarcó
F
F
García-Díez
J M
JM
Mahiques
E
E
Domingo
J V
JV
D000328:Adult; D000368:Aged; D005260:Female; D006207:Half-Life; D006801:Humans; D007688:Kidneys, Artificial; D008297:Male; D008875:Middle Aged; D009428:Netilmicin / Q000493:pharmacokinetics*; D006435:Renal Dialysis
D009428:Netilmicin