Complex chromosome rearrangements involving chromosomes 1;3 and 2;3 in two abnormal children.
Complex chromosome rearrangements (CCR) involving multiple breaks in two chromosomes are rare. The detection of a four-break apparently balanced rearrangement involving chromosomes 1 and 3 in a child with developmental delay led us to reanalyse, using prometaphase banding, another complex two-chromosome rearrangement in a previously reported case (Fitzgerald 1974). The relationship between clinical abnormalities and apparently balanced rearrangements is discussed.
Voullaire
L E
LE
Department of Genetics, Royal Children's Hospital, Melbourne, Australia.
Webb
G C
GC
D002648:Child; D002675:Child, Preschool; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000648:ultrastructure*; D002889:Chromosomes, Human, Pair 2 / Q000648:ultrastructure*; D002893:Chromosomes, Human, Pair 3 / Q000648:ultrastructure*; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D010641:Phenotype; D014178:Translocation, Genetic