[Effect of astasilid on the stimulation of peritoneal macrophages].
The effect of astasilid, a sucrose monoester and the effect of mainly unsaturated fatty acids from the lipid fraction of Astasia longa on immunocompetent cells--macrophages of the mouse peritoneal cavity were studied. It was shown that astasilid increased 7.5-8.5-fold expression of Fc-receptors on the macrophage plasmic membranes and stimulated 5.5-6.5-fold the macrophage capacity for Fc-dependent phagocytosis of sheep red blood cells. Astasilid had no effect on migration of the macrophages into the abdominal cavity.
Makarenko
I G
IG
Sukhareva
N N
NN
Khorokhorina
V A
VA
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000494:pharmacology*; D007958:Leukocyte Count / Q000187:drug effects; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010529:Peritoneal Cavity / Q000166:cytology*; D010587:Phagocytosis / Q000187:drug effects; D011961:Receptors, Fc / Q000187:drug effects; D013997:Time Factors
D000276:Adjuvants, Immunologic; D005227:Fatty Acids; D011961:Receptors, Fc; C052057:astasilid
Vliianie astazilida na stimuliatsiiu peritoneal'nykh makrofagov.