The effects of high iodine on the brain development of mice.
C57 mice were divided into two groups: (A): experiment group (H group). Each female mouse was injected with 20 microliter iodized oil; (B): control group (N group). Both groups were mated 8 days after iodized oil injection. Urine iodine contents/24 h of H group was 20 times higher than that in N group 7 days after injection and 18 times higher two months later. Serum T4 values were determined. Brain protein, DNA, body weight, motility and learning ability were measured in the progeny. The results indicate that there was no statistically significant difference between the groups in any of the parameters mentioned above. This strongly suggests that a high iodine dose, given as iodized oil, does not have obvious damaging effects on brain development, at least in mice.
Liu
X L
XL
Institute of Endocrinology, Tianjin Medical College, China.
Chen
Z P
ZP
Chu
X L
XL
Hu
X
X
Hou
B Z
BZ
Yuan
S Y
SY
Guo
Y H
YH
Ma
T
T
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000254:growth & development*; D005260:Female; D007455:Iodine / Q000494:pharmacology* / Q000652:urine; D007858:Learning / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013961:Thyroid Gland / Q000166:cytology; D013974:Thyroxine / Q000097:blood
D007455:Iodine; D013974:Thyroxine