title: [125I-n-iodophenamine as a prototype compound for the study of microsomal oxidation].
abstract: Dynamics of distribution and excretion with urine of 125I-p-iodophenamine were studied impairment of rat liver tissue microsomal oxidation by means of CC14 treatment. This poison inhibited distinctly metabolism and excretion of the labelled compound in rats but not in rabbits, which was due to difference in the mechanisms of the compound biotransformation. The requirements for compounds suitable for studies of microsomal oxidation by means of excretory test were not met by 125I-p-iodophenamine.
authors.forename: I N
authors.initials: IN
authors.lastname: Kendysh
authors.forename: V A
authors.initials: VA
authors.lastname: Bratsev
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Gol'tiapin
authors.forename: T V
authors.initials: TV
authors.lastname: Klimova
authors.forename: T N
authors.initials: TN
authors.lastname: Smirnova
mesh_terms: D000661:Amphetamine / Q000652:urine; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000175:diagnosis* / Q000652:urine; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005069:Evaluation Studies as Topic; D005260:Female; D007457:Iodine Radioisotopes; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D010084:Oxidation-Reduction; D011817:Rabbits; D051381:Rats
chemical_list: D007457:Iodine Radioisotopes; D003577:Cytochrome P-450 Enzyme System; D000661:Amphetamine
vernacular_title: 125I-n-ĭodfenamin kak prototip sredstva issledovaniia mikrosomal'nogo okisleniia.