[Characteristics of the effect of hydrocortisone on biosynthesis of mitochondrial proteins in the liver of thyroidectomized rats].
Biosynthesis of different groups of mitochondrial proteins was studied in liver cells of control and thyroidectomized rats after hydrocortisone administration. The hormone augmented protein biosynthesis in liver mitochondria within 15 min but the effect was less distinct in thyroidectomized rats. After hydrocortisone administration into intact rats the rate of liver mitochondrial proteins biosynthesis, coded by mitochondrial genes, was considerably higher as compared with those effects of nuclear genes, while biosynthesis of mitochondrial proteins was similarly increased in thyroidectomized rats. Hydrocortisone stimulated protein biosynthesis in matrix, inner and outer mitochondrial membranes of intact and thyroidectomized rats, whereas the biosynthesis was altered less distinctly in outer membranes. These data suggest that the effect of hydrocortisone on biosynthesis of proteins in mitochondria depended on content of thyroid hormones.
Minchenko
A G
AG
D000818:Animals; D006854:Hydrocortisone / Q000494:pharmacology*; D007930:Leucine / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy
D008565:Membrane Proteins; D007930:Leucine; D006854:Hydrocortisone
Osobennosti deĭstviia gidrokortizona na biosintez mitokhondrial'nykh belkov v pecheni tireoidéktomirovannykh krys.