Desipramine antagonizes clonidine-induced suppression of dominance in rats: possible involvement of amygdaloid nuclei.
Bilateral microinjections of clonidine into the medial or basal amygdaloid nuclei suppressed the dominance behavior in rats competing for food. Desipramine given in five repeated daily doses antagonized clonidine effect. On the other hand suppression of dominance induced by clonidine given bilaterally into the cortical amygdaloid nucleus was resistant to desipramine treatment. The result suggests that the former nuclei are important target areas for clonidine-desipramine interaction at social interaction behavioral level.
Malatyńska
E
E
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
Kostowski
W
W
D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D003000:Clonidine / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D003891:Desipramine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008845:Microinjections; D051381:Rats; D011919:Rats, Inbred Strains; D012930:Social Dominance
D003000:Clonidine; D003891:Desipramine