[Effect of the development of portosystemic shunts in the maintenance of portal hypertension in rats].
We studied the role of portosystemic shunt development in the maintenance of portal hypertension in a prehepatic portal hypertension rat model. A first group was studied two days after partial portal vein ligation. When portosystemic shunts were negligible; the second group was studied 3 weeks after the partial portal vein ligation, when large portosystemic shunts were present. Portal pressure was significantly higher in the first group than in the second group (19.9 +/- 0.8 mmHg (mean +/- 1 SD) and 12.8 +/- 2.3 mmHg, respectively; p less than 0.001). When compared with sham operated rats: a) portal tributary blood flow (measured with the radioactive microspheres method) was decreased in the first group (- 34 p. 100; p less than 0.01) and increased in the second group (+ 32 p. 100; p less than 0.02); b) portal system vascular resistance was markedly increased in the first group (+ 269 p. 100; p less than 0.001) and did not significantly change in the second group (+ 30 p. 100). These results suggest that portosystemic shunt development decreases portal pressure but not to normal value because portal tributary blood flow is increased. Moreover the increase in portal system vascular resistance and in portal tributary blood flow play different roles in the maintenance of portal hypertension depending on the stage of evolution of portal hypertension.
Braillon
A
A
Unité de Recherches de Physiopathologie Hépatique, INSERM U24, Hôpital Beaujon, Clichy.
Koshy
A
A
Lee
S S
SS
Girod
C
C
Lebrec
D
D
D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D003097:Collateral Circulation; D004195:Disease Models, Animal; D006439:Hemodynamics; D006975:Hypertension, Portal / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013152:Splanchnic Circulation; D013997:Time Factors
Effet du développement des shunts porto-systémiques dans le maintien de l'hypertension portale chez le rat.