title: [Prolonged anticoagulation following chlorophacinone poisoning].
abstract: In 1985 and 1986 the Swiss Toxicologic Information Center registered 152 cases of rodenticide poisoning. Among those substances chlorophacinone, an indanedione derivative, has a prolonged antivitamin K effect. We report here the case of an eighteen-year-old female hospitalized 3 days after deliberately ingesting some 100 mg chlorophacinone. Her Quick time at admission was less than 10% (Prothrombin time 79 sec., normal control 12 sec.). Under high dose vitamin K therapy the Quick was rapidly corrected but fell again on each vitamin K withdrawal. In a search for a relation between the variations of prothrombin time and chlorophacinone plasma levels, these were assessed by HPLC. Prothrombin time (and vitamin K dependent factors VII and X) finally normalized only 7 weeks after chlorophacinone ingestion. Clinical condition remained satisfactory throughout and other biological parameters unaffected. This case emphasizes the need for prolonged clinical and laboratory follow-up for rodenticide intoxications and for vitamin K administration for several weeks.
authors.affiliation: Département de médecine, Hôpital cantonal universitaire, Genève.
authors.forename: J J
authors.initials: JJ
authors.lastname: Vogel
authors.forename: P
authors.initials: P
authors.lastname: de Moerloose
authors.forename: C A
authors.initials: CA
authors.lastname: Bouvier
authors.forename: J
authors.initials: J
authors.lastname: Gaspoz
authors.forename: P
authors.initials: P
authors.lastname: Riant
mesh_terms: D000293:Adolescent; D000925:Anticoagulants / Q000506:poisoning*; D005260:Female; D006801:Humans; D007189:Indans / Q000506:poisoning*; D007192:Indenes / Q000506:poisoning*; D012378:Rodenticides / Q000506:poisoning*; D013406:Suicide, Attempted; D013997:Time Factors; D014812:Vitamin K / Q000037:antagonists & inhibitors / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D007189:Indans; D007192:Indenes; D012378:Rodenticides; D014812:Vitamin K; C004662:chlorophacinone
vernacular_title: Anticoagulation prolongée lors d'une intoxication à la chlorphacinone.