Simple micromotility recorder for rapid screening of potentially anthelmintic compounds.
A simple micromotility recorder for monitoring the motility of small nematodes (adult) is described. Normal motility of Ancylostoma ceylanicum and Nematospiroides dubius was recorded. The time course to cause paralysis (paralysis time) was also observed in the presence of various anthelmintics, e.g., Levamisole, Pyrantel; and Ivermectin at graded concentrations. This is a simple in vitro model for screening of potential anthelmintic compounds.
Das
A K
AK
Organon Research Centre, Calcutta, India.
Bhattacharya
S
S
Chatterjee
G K
GK
Chaudhuri
S K
SK
D000722:Ancylostoma / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation*; D009068:Movement / Q000187:drug effects; D009351:Nematospiroides dubius / Q000187:drug effects / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects; D010243:Paralysis / Q000139:chemically induced
D000871:Anthelmintics