Hair protein glycation as a long-term index of blood glucose in diabetics.
We used furosine, which is derived from fructose-lysine and is a glycation product, to measure the extent of hair protein glycation in diabetic patients. We took hair samples that were 12 cm long, corresponding roughly to 1 year's growth. While the furosine levels in these samples correlated poorly with fasting plasma glucose (FPG) and with hemoglobin A1c (HbA1c) levels at the time of sampling, better correlations were observed between glycation and the year-long average values of FPG, HbA1c, and the conduction velocities in two peripheral nerves. The glycation levels in these samples may thus reflect the year-long average of the patient's blood glucose. Hair glycation may serve as a valuable indicator both of long-term blood glucose trends and of the relationship between diabetic complications and blood glucose.
Oimomi
M
M
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Igaki
N
N
Masuda
S
S
Hata
F
F
Maeda
Y
Y
Matsumoto
S
S
Baba
S
S
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis*; D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006023:Glycoproteins / Q000032:analysis*; D006031:Glycosylation; D006197:Hair / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010543:Peroneal Nerve / Q000503:physiopathology; D013497:Sural Nerve / Q000503:physiopathology
D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D006023:Glycoproteins