Hypolipidemic effect of NS-1 and other related drugs in rhesus monkeys.
NS-1, 4-[2-(4-isopropylbenzamido)ethoxy]benzoic acid, is a novel chemical compound which has been found to be a potent hypolipidemic agent in rhesus monkeys. Significant reductions in serum cholesterol and phospholipids were observed in normolipidemic monkeys following oral doses of 30-300 mg/kg/day. A dose of 300 mg/kg/day for 28 days lowered serum cholesterol and phospholipid levels by 49% and 41%, respectively. NS-1 was more potent than clofibrate, clinofibrate, simfibrate, bezafibrate, gemfibrozil, nicomol and probucol in hypolipidemic activity in the same model. Lipoprotein analysis showed that NS-1 reduced low density lipoprotein much more than high density lipoprotein. The results suggest that NS-1 may have hypolipidemic activity in hyperlipidemic patients.
Yoshikuni
Y
Y
Research Laboratories, Nippon Shinyaku Co., Ltd., Kyoto, Japan.
Chokai
S
S
Ozaki
T
T
Yoshida
H
H
Nakane
M
M
Kuwabara
K
K
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001565:Benzoates / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D007441:Intubation, Gastrointestinal; D008253:Macaca mulatta; D008297:Male
D000924:Anticholesteremic Agents; D001565:Benzoates; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; C058271:4-(2-(4-isopropylbenzamido)ethoxy)benzoic acid; D002784:Cholesterol