Growth characteristics of cultured human normal bladder epithelial cells: a comparison with urothelial carcinoma cell cultures.
We present the in vitro growth characteristics and morphology of the first established long-term culture of human normal bladder epithelium. Normal bladder cells were grown with a mean generation time of 44 h and a life span of 33 population doublings in 12 weeks. The cells exhibited contact inhibition of growth. The cultures were morphologically examined and compared with transitional cell carcinoma in culture.
Logothetou-Rella
H
H
Department of Experimental Physiology, University of Athens Medical School, Greece.
Nesland
J M
JM
Karayiannis
A
A
Dimopoulos
C
C
D000328:Adult; D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D002455:Cell Division; D002460:Cell Line; D002470:Cell Survival; D006801:Humans; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D008297:Male; D008854:Microscopy, Electron; D014407:Tumor Cells, Cultured; D001743:Urinary Bladder / Q000166:cytology*; D001749:Urinary Bladder Neoplasms / Q000473:pathology*