title: Effect of ornithine on transferrin secretion of rat and human hepatocyte cultures.
abstract: Fetal rat or neonatal human hepatocytes and a human hepatoma cell line were cultured in an arginine-free medium, supplemented or not with L-ornithine. This amino-acid improved survival of hepatocytes and strongly enhanced their transferrin secretion. Moreover, this increase observed in transferrin production was well correlated with a higher corresponding mRNA level. Thus, it may be postulated that the mechanism involved in the increased transferrin secretion by L-ornithine is of pretranslational origin.
authors.affiliation: Unité de Recherches Hépatologiques U 49 de l'INSERM, Hôpital de Pontchaillou, Rennes, France.
authors.forename: G
authors.initials: G
authors.lastname: Lescoat
authors.forename: O
authors.initials: O
authors.lastname: Loreal
authors.forename: B
authors.initials: B
authors.lastname: Desvergne
authors.forename: N
authors.initials: N
authors.lastname: Pasdeloup
authors.forename: Y
authors.initials: Y
authors.lastname: Deugnier
authors.forename: P
authors.initials: P
authors.lastname: Brissot
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005333:Fetus; D006801:Humans; D008099:Liver / Q000166:cytology*; D009952:Ornithine / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D014168:Transferrin / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D012333:RNA, Messenger; D014168:Transferrin; D009952:Ornithine