Alteration of inositol phospholipid metabolism in rat cortex by lithium but not carbamazepine.
The effect of carbamazepine on inositol phospholipid metabolism was investigated in rat cerebral cortex. The stimulation of inositol phosphate formation by 5-HT (10 microM), carbachol (100 microM) and noradrenaline (30 microM) was not significantly altered by carbamazepine in vitro. 14 days treatment of rats in vivo with carbamazepine was similarly without effect on these parameters. In contrast 14 days treatment with LiCl reduced the agonist responses by 25-50%. The results are discussed in relation to the therapeutic actions of these drugs.
Elphick
M
M
Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, U.K.
Taghavi
Z
Z
Powell
T
T
Godfrey
P P
PP
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D002220:Carbamazepine / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D007295:Inositol Phosphates / Q000378:metabolism*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology; D013403:Sugar Phosphates / Q000378:metabolism*
D007295:Inositol Phosphates; D013403:Sugar Phosphates; D012701:Serotonin; D002220:Carbamazepine; D002217:Carbachol; D008094:Lithium; D009638:Norepinephrine