title: L-657,398, a novel antifungal agent: fermentation, isolation, structural elucidation and biological properties.
abstract: L-657,398 is a broad spectrum antifungal agent isolated from solid fermentation or from the mycelium of the liquid fermentation of Aspergillus ochraceus. Structurally, the compound is a novel pyrollidine related to anisomycin.
authors.affiliation: Merck Sharp & Dohme Research Laboratories, Rahway, N.J.
authors.forename: R E
authors.initials: RE
authors.lastname: Schwartz
authors.forename: J
authors.initials: J
authors.lastname: Liesch
authors.forename: O
authors.initials: O
authors.lastname: Hensens
authors.forename: L
authors.initials: L
authors.lastname: Zitano
authors.forename: S
authors.initials: S
authors.lastname: Honeycutt
authors.forename: G
authors.initials: G
authors.lastname: Garrity
authors.forename: R A
authors.initials: RA
authors.lastname: Fromtling
authors.forename: J
authors.initials: J
authors.lastname: Onishi
authors.forename: R
authors.initials: R
authors.lastname: Monaghan
mesh_terms: D000841:Anisomycin / Q000031:analogs & derivatives / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D011759:Pyrrolidines / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; D011759:Pyrrolidines; C058280:preussin; D000841:Anisomycin