Inhibitory activity of 2-benzimidazolylurea on gastric acid secretion in rats.
2-Benzimidazolylurea (BIU) decreases gastric acid secretion. The antisecretive activity appears to be associated with antihistaminic and antimuscarinic effects. The antihistaminic activity of BIU appears from its inhibitory effects on betazole stimulated gastric acid secretion and from its inhibitory activity on the isolated guinea pig auricle stimulated by betazole. The antimuscarinic activity of BIU appears from several experiments: this molecule decreases gastric acid secretion stimulated by carbachol in rats, depresses the neostigmine-stimulated motility of duodenum in the anaesthetized cat, lessens the hypertonus of isolated guinea pig trachea caused by pilocarpine and also inhibits guinea pig ileum activity stimulated by acetylcholine. BIU probably depresses gastric acid secretion by interfering with both histamine and acetylcholine receptors.
Trivulzio
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Department of Pharmacology Chemotherapy and Medical Toxicology, University of Milan.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001625:Betazole / Q000494:pharmacology; D002415:Cats; D004386:Duodenum / Q000187:drug effects / Q000502:physiology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006168:Guinea Pigs; D007082:Ileum / Q000502:physiology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D014132:Trachea / Q000502:physiology; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
D010862:Pilocarpine; D001625:Betazole; C051850:2-benzimidazolylurea; D014508:Urea; D000109:Acetylcholine