The biosynthetic origins of rebeccamycin.
Experimental evidence is presented to demonstrate that the antitumor-antibiotic rebeccamycin is biosynthesized by Saccharothrix aerocolonigenes from one unit of glucose, one of methionine, and two of tryptophan. Evidence is presented that suggests that the alpha-amino group of neither tryptophan unit provides the nitrogen of the phthalimide system.
Pearce
C J
CJ
Bristol-Myers Pharmaceutical Research and Development Division, Wallingford, Connecticut 06492.
Doyle
T W
TW
Forenza
S
S
Lam
K S
KS
Schroeder
D R
DR
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D002227:Carbazoles; D005947:Glucose / Q000378:metabolism; D007211:Indoles; D009682:Magnetic Resonance Spectroscopy; D008715:Methionine / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D002227:Carbazoles; D007211:Indoles; D014364:Tryptophan; C053339:rebeccamycin; D008715:Methionine; D005947:Glucose