title: [New analgesically-active N'-acylated phenylpiperazines].
abstract: Synthesis and pharmacodynamic properties of new analgesic active N'-acylated phenylpiperazines are described. 1-(3-Cyclohexyl-1-oxo-propyl)-4-(2-ethoxyphenyl)-piperazine (D 16 120) possesses strong non-opiate antinociceptive activity showing high therapeutic margin with respect to undesired side effects and toxicity.
authors.affiliation: Forschung der Asta Pharma AG, Frankfurt/Main.
authors.forename: G
authors.initials: G
authors.lastname: Oepen
authors.forename: A
authors.initials: A
authors.lastname: Bork
authors.forename: V
authors.initials: V
authors.lastname: Jakovlev
authors.forename: B
authors.initials: B
authors.lastname: Nickel
authors.forename: K
authors.initials: K
authors.lastname: Thiemer
authors.forename: J
authors.initials: J
authors.lastname: Engel
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats
chemical_list: D000700:Analgesics; D010879:Piperazines; C031503:phenylpiperazine
vernacular_title: Neue analgetisch wirksame N'-acylierte Phenylpiperazine.