Diurnal and episodic variations of plasma hydrocortisone concentrations in horses.
Using a specific high-performance liquid chromatographic technique, plasma hydrocortisone values were measured hourly in 6 horses and every 10 minutes in 4 horses over 24 hours. Both circadian and episodic variation was observed. The mean plasma hydrocortisone concentration was a maximum of 58.8 +/- 9.54 ng/ml at 9.19 +/- 0.59 hr and a minimum of 27.85 +/- 6.85 g/ml at 21.19 +/- 0.59 hr. The number of episodes of secretion was 10.0 +/- 1.41; the mean amplitude and duration of peak were 26.21 +/- 3.71 ng/ml and 105.25 +/- 21.24 min respectively.
Toutain
P L
PL
INRA, Station de Pharmacologie, Toulouse, France.
Oukessou
M
M
Autefage
A
A
Alvinerie
M
M
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002940:Circadian Rhythm; D005260:Female; D006736:Horses / Q000097:blood*; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D010507:Periodicity
D006854:Hydrocortisone