title: t(1;7) in acute myeloblastic leukemia following myelodysplastic syndrome (RAEB-T).
abstract: A case is described of myelodysplastic syndrome (MDS) refractory anemia type with an excess of blasts in transformation with early leukemic evolution (AML-M1). All bone marrow cells examined showed an unbalanced translocation t(1;7). The karyotype was 45, xy, -21, -7, + der dic t(1;7) (q12;q21). There are reports in the literature of the translocation t(1;7) (p11;p11), which leads to trisomy of the long arms of chromosome #1 and monosomy of the long arms of chromosome #7. In the case here described the breakpoints of the chromosomes involved in the translocation differ from the classic ones: in this case there is trisomy of the region 1q12----1qter and monosomy of the region 7q21----7qter. Some clinical and cytogenetic considerations are suggested.
authors.affiliation: Cattedra di Biologia Generale R, Genova, Italia.
authors.forename: R
authors.initials: R
authors.lastname: Defferrari
authors.forename: M
authors.initials: M
authors.lastname: Sessarego
authors.forename: G
authors.initials: G
authors.lastname: Santini
authors.forename: F
authors.initials: F
authors.lastname: Ajmar
mesh_terms: D000328:Adult; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000235:genetics*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000235:genetics*; D014178:Translocation, Genetic