title: Pulmonary microembolization in experimental aortic surgery.
abstract: Pulmonary dysfunction frequently follows major surgery and has many features identical to "shock lung'. A porcine model of aortic surgery is described in which 111In-labelled platelet kinetics were related to subsequent pulmonary function. In 14 pigs, standardized aortic surgery resulted in reproducible shock and a 50 per cent mortality at 3 days. Cardiac output fell from 2.3 +/- 0.2 to 1.0 +/- 0.1 litres min-1 following removal of the aortic clamp and mean platelet and leucocyte counts fell from 437 +/- 48 to 252 +/- 39 x 10(9) litres-1 and 21.7 +/- 1.5 to 12.9 +/- 1.2 x 10(9) litres-1 respectively (P less than 0.01). Aggregate levels in inferior vena caval blood were maximal at this time and radiolabelled platelets accumulated in the lung with a rise in pulmonary vascular resistance. Alveolar-arterial oxygen difference subsequently increased from initial values of 13.7 +/- 2.0 to 23.4 +/- 3.5 mmHg (P less than 0.01) following resuscitation and to 32.5 +/- 3.4 mmHg at 3 days following surgery (P less than 0.01). This clear sequence suggests that pulmonary platelet microembolization occurs during surgical shock and may be responsible for subsequent pulmonary dysfunction.
authors.affiliation: Department of Surgery, Charing Cross Hospital, London, UK.
authors.forename: K R
authors.initials: KR
authors.lastname: Poskitt
authors.forename: J T
authors.initials: JT
authors.lastname: Irwin
authors.forename: I F
authors.initials: IF
authors.lastname: Lane
authors.forename: S
authors.initials: S
authors.lastname: Karacagil
authors.forename: C N
authors.initials: CN
authors.lastname: McCollum
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery*; D004195:Disease Models, Animal; D005260:Female; D007958:Leukocyte Count; D008168:Lung / Q000503:physiopathology; D010100:Oxygen / Q000502:physiology; D010974:Platelet Aggregation; D010976:Platelet Count; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D011655:Pulmonary Embolism / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D012773:Shock, Surgical / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D013552:Swine; D014655:Vascular Resistance
chemical_list: D010100:Oxygen