Analysis of lung air from patients with bronchogenic carcinoma and controls using gas chromatography-mass spectrometry.
Volatile metabolites present in expired lung air were collected by odor sampling techniques and analyzed by gas chromatography-mass spectrometry. The study population included controls matched for age and smoking history with patients newly diagnosed with lung carcinoma. Significantly greater concentrations of o-toluidine were found in the lung air of patients with lung carcinoma than either age-matched or younger controls. Aniline was present in half of the patient population but absent in age-matched controls.
Preti
G
G
Monell Chemical Senses Center, Philadelphia, PA 19104.
Labows
J N
JN
Kostelc
J G
JG
Aldinger
S
S
Daniele
R
R
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism; D000388:Air / Q000032:analysis*; D000814:Aniline Compounds; D002283:Carcinoma, Bronchogenic / Q000032:analysis*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008168:Lung / Q000032:analysis*; D008175:Lung Neoplasms / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D014048:Tolonium Chloride
D000814:Aniline Compounds; D014048:Tolonium Chloride