A comparative study of the permeation of dihexadecyl phosphate vesicles by various carboxylic acids and some of their tetrazole analogues.
The evaluation of the effect that perturbers may have on a membrane model is described. The model was made from dihexadecyl phosphate bilayers. The perturbers used were carboxylic acids and some of their tetrazole analogues. The results show a good correlation between the permeation properties of the carboxylic acids and tetrazole analogues. Moreover, this study reveals that membrane-perturbing effects are mainly under the control of conformational parameters and dependent on the carbon chain length of the permeants.
Pernice
P
P
Département de Chimie, Faculté des Sciences de Luminy, Marseille, France.
Castaing
M
M
Ménassa
P
P
Kraus
J L
JL
D001393:Azoles; D002264:Carboxylic Acids; D008567:Membranes, Artificial; D008954:Models, Biological; D008968:Molecular Conformation; D010755:Organophosphates; D009943:Organophosphorus Compounds; D013329:Structure-Activity Relationship; D013777:Tetrazoles
D001393:Azoles; D002264:Carboxylic Acids; D008567:Membranes, Artificial; D010755:Organophosphates; D009943:Organophosphorus Compounds; D013777:Tetrazoles; C002290:dicetylphosphate