title: Posterior capsular opacification and intraocular lens decentration. Part II: Experimental findings on a prototype circular intraocular lens design.
abstract: In a prospective randomized study, 25 New Zealand white rabbit eyes were implanted with four intraocular lens (IOL) designs. These included a one-piece modified J-loop IOL, a three-piece modified J-loop IOL, a rigid disc IOL, and an experimental compressible disc (CD) IOL. The CD IOL revealed the lowest mean posterior capsular opacification (PCO) of all IOLs tested (P less than .01). With all lenses tested, a positive correlation between PCO and decentration was found (R = 0.55, P less than .05). These results suggest that because of its design features (i.e., one-piece construction, biconvex optic, posterior angulation of the fixation element), the CD lens produces a mechanical barrier against lens epithelial cell migration and reduces the incidence of PCO.
authors.affiliation: Department of Ophthalmology, University of Utah Health Sciences Center, Salt Lake City.
authors.forename: M R
authors.initials: MR
authors.lastname: Tetz
authors.forename: D J
authors.initials: DJ
authors.lastname: O'Morchoe
authors.forename: T D
authors.initials: TD
authors.lastname: Gwin
authors.forename: T H
authors.initials: TH
authors.lastname: Wilbrandt
authors.forename: K D
authors.initials: KD
authors.lastname: Solomon
authors.forename: S O
authors.initials: SO
authors.lastname: Hansen
authors.forename: D J
authors.initials: DJ
authors.lastname: Apple
mesh_terms: D000818:Animals; D002387:Cataract Extraction; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D007903:Lens Capsule, Crystalline / Q000601:surgery; D007910:Lenses, Intraocular / Q000009:adverse effects* / Q000379:methods; D011446:Prospective Studies; D011817:Rabbits