title: Brain pH in migraine: an in vivo phosphorus-31 magnetic resonance spectroscopy study.
abstract: The intracellular pH (pHi) of cerebral cortex was measured in migraine patients by use of in vivo phosphorus-31 NMR spectroscopy. No changes in pHi were measured during a migraine attack. The long-standing concept that the headache of migraine is due to cerebral vasodilation induced by prodromal vasospasm-induced ischemic acidosis is not substantiated.
authors.affiliation: Department of Neurology, Henry Ford Hospital, Detroit, MI 48202.
authors.forename: K M
authors.initials: KM
authors.lastname: Welch
authors.forename: S R
authors.initials: SR
authors.lastname: Levine
authors.forename: G
authors.initials: G
authors.lastname: D'Andrea
authors.forename: J A
authors.initials: JA
authors.lastname: Helpern
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D008881:Migraine Disorders / Q000378:metabolism*