title: Lithium, polyuria and abnormal diurnal weight gain in psychosis.
abstract: We evaluated diurnal weight gain and polyuria among 31 institutionalized chronically psychotic patients receiving lithium and 42 controls not receiving this drug. The patients were weighed weekly for three weeks at 7 a.m. and 4 p.m. We normalized the diurnal weight gain (NDWG) as a percentage by subtracting the 7 a.m. weight from the 4 p.m. weight, multiplying the difference by 100, and then dividing the result by the 7 a.m. weight. Polyuria was assessed using mean urine creatinine concentration (MUCR). NDWG was abnormal among study patients (1.9 +/- 1.2%) and controls (1.6 +/- 1.5%) independent of lithium treatment. The variation in MUCR explained about 20% of the variation in NDWG in both groups.
authors.affiliation: Western State Hospital, Department of Mental Health and Mental Retardation, Virginia.
authors.forename: W V
authors.initials: WV
authors.lastname: Vieweg
authors.forename: L S
authors.initials: LS
authors.lastname: Godleski
authors.forename: P L
authors.initials: PL
authors.lastname: Hundley
authors.forename: G R
authors.initials: GR
authors.lastname: Yank
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D019965:Neurocognitive Disorders / Q000188:drug therapy; D011141:Polyuria / Q000139:chemically induced*; D011618:Psychotic Disorders / Q000188:drug therapy*; D012559:Schizophrenia / Q000188:drug therapy; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D008094:Lithium