[Positive reinforcing properties of klofelin].
The primary and secondary reinforcing and analgesic effects of clonidine were compared with those of morphine in the experiments on rats. Clonidine was demonstrated to possess weak positive reinforcing properties that make it possible to predict a relatively low narcogenic potential of this drug in comparison with morphine at the equianalgesic doses.
Marusov
I V
IV
Patkina
N A
NA
Zaĭtsev
A A
AA
D000700:Analgesics; D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D009020:Morphine / Q000494:pharmacology; D051381:Rats; D012054:Reinforcement, Psychology; D012646:Self Administration
D000700:Analgesics; D009020:Morphine; D003000:Clonidine
Izuchenie pozitivno-podkrepliaiushchikh svoĭstv klofelina.