title: Amino acid levels in depression: a preliminary investigation.
abstract: Plasma, cerebrospinal fluid and brain tissue amino acid levels were measured in 14 patients with affective illness and generally confirm previous findings. There was no correlation between these values and age, sex, family history and levels of anxiety. GABA levels measured in cortex tissue were negatively correlated with depressive mood (P less than 0.05), supporting a possible involvement of GABA in depressive illness.
authors.affiliation: Geoffrey Knight Unit for Affective Disorders, Brook General Hospital, London, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Honig
authors.forename: J R
authors.initials: JR
authors.lastname: Bartlett
authors.forename: N
authors.initials: N
authors.lastname: Bouras
authors.forename: P K
authors.initials: PK
authors.lastname: Bridges
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000378:metabolism*; D001714:Bipolar Disorder / Q000378:metabolism; D001812:Blood-Brain Barrier; D003866:Depressive Disorder / Q000378:metabolism* / Q000523:psychology / Q000601:surgery; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011581:Psychological Tests; D011594:Psychometrics; D011612:Psychosurgery
chemical_list: D000596:Amino Acids