title: 1,2,3-Triazoles: structural changes on two effective inhibitors of the prostaglandin synthesis in vitro.
abstract: This paper describes the synthesis and the biological evaluation of some 1,2,3-triazoles which represent structural modifications of two compounds which are effective inhibitors of the prostaglandin synthesis in vitro. These modifications, concerning the elimination of the methylene bridge and/or the ether oxygen from the active molecules, show that every introduced structural changes caused a strong decrease of activity.
authors.affiliation: Istituto di Chimica Farmaceutica, Università di Pisa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Biagi
authors.forename: O
authors.initials: O
authors.lastname: Livi
authors.forename: V
authors.initials: V
authors.lastname: Scartoni
authors.forename: E
authors.initials: E
authors.lastname: Verugi
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008315:Malondialdehyde / Q000097:blood; D011448:Prostaglandin Antagonists / Q000138:chemical synthesis*; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D011448:Prostaglandin Antagonists; D014230:Triazoles; D008315:Malondialdehyde