title: [Synthesis and antifungal activity of new derivatives of 5-(4-halobenzoyl)-4-amino-3-(2-dialkylaminoethylthio)thieno [2,3-c] and [3,2-d] isothiazole].
abstract: A new series of 5-(4-halobenzoyl)-4-amino-3-(2-dialkylamino-ethylthio)thieno [2,3-c] and [3,2-d] isothiazole derivatives has been synthetized. The compounds were evaluated for antifungal activity on yeast and dermatophytes. The compound (VI b) resulted about thirty times less potent than miconazole on dermatophytes.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania.
authors.forename: G
authors.initials: G
authors.lastname: Romeo
authors.forename: E
authors.initials: E
authors.lastname: Bousquet
authors.forename: M S
authors.initials: MS
authors.lastname: Pappalardo
authors.forename: G
authors.initials: G
authors.lastname: Ronsisvalle
authors.forename: S
authors.initials: S
authors.lastname: Oliveri
authors.forename: E
authors.initials: E
authors.lastname: Cammarata
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis*; D001565:Benzoates / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D001565:Benzoates; D013844:Thiazoles; D013876:Thiophenes
vernacular_title: Sintesi ed attività antifungina di nuovi derivati 5-(4-alobenzoil)-4-ammino-3-(2-dialchilamminoetiltio)tieno [2,3-c] e [3,2-b] isotiazolici.