[Semisynthetic derivatives of daunorubicin and carminomycin: inhibition of DNA synthesis after intravenous administration to mice].
Inhibition of DNA synthesis in the liver, kidneys, spleen and heart of mice after intravenous administration of 0.1 and 0.3 LD50 of semisynthetic derivatives of rubomycin (daunorubicin) and carminomycin was studied. The level of DNA synthesis inhibition was estimated by a decrease in incorporation of (methyl-3H) thymidine. Under the action of 13-trebutoxycarbonyl hydrazone and 14-salicyloiloxy derivatives of rubomycin and carminomycin maximum inhibition of DNA synthesis was reached later while its recovery started earlier as compared to the initial antibiotics.
Reznikova
M I
MI
Dudnik
Iu V
IuV
D000818:Animals; D002360:Carubicin / Q000008:administration & dosage / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis* / Q000187:drug effects; D003630:Daunorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003864:Depression, Chemical; D005260:Female; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D013154:Spleen / Q000378:metabolism
D004247:DNA; D002360:Carubicin; D003630:Daunorubicin
Polusinteticheskie proizvodnye daunorubitsina i karminomitsina--podavlenie sinteza DNK pri vnutrivennom vvedenii mysham.