title: Clonidine: placental transfer and neonatal adaption.
abstract: The placental transfer of clonidine was investigated in five pregnancies. Clonidine readily crosses the placenta. The drug elimination in neonates was slow, but the only clinical abnormality was that of a raised arterial blood pressure. Hypertension for at least 24 h was observed in four cases. It is suggested that this may be related to a withdrawal syndrome due to the sudden cessation of the placentally transferred drug.
authors.affiliation: INSERM Unit 272, University of Nancy, France.
authors.forename: M J
authors.initials: MJ
authors.lastname: Boutroy
authors.forename: C R
authors.initials: CR
authors.lastname: Gisonna
authors.forename: M
authors.initials: M
authors.lastname: Legagneur
mesh_terms: D000328:Adult; D003000:Clonidine / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D008431:Maternal-Fetal Exchange; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy
chemical_list: D003000:Clonidine