title: Can deferoxamine be considered an ototoxic drug?
abstract: Some uncertainty about deferoxamine ototoxicity is to be found in the literature. Therefore, 100 patients affected by beta-thalassemia were checked audiologically. Twelve of them showed a sensorineural hearing impairment which in most cases was confined to 4 and 8 kHz. If these results are compared with a sample of "normal" population, no significant difference can be observed, therefore excluding that deferoxamine, at least at present dosages, may be considered as a certain cause of cochlear impairment.
authors.affiliation: ENT Clinic, University of Sassari, Italy.
authors.forename: W
authors.initials: W
authors.lastname: Masala
authors.forename: F
authors.initials: F
authors.lastname: Meloni
authors.forename: D
authors.initials: D
authors.lastname: Gallisai
authors.forename: M
authors.initials: M
authors.lastname: Careddu
authors.forename: G
authors.initials: G
authors.lastname: Secchi
authors.forename: G B
authors.initials: GB
authors.lastname: Cuccuru
authors.forename: V
authors.initials: V
authors.lastname: Loriga
authors.forename: G
authors.initials: G
authors.lastname: Salvo
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003676:Deferoxamine / Q000009:adverse effects* / Q000627:therapeutic use; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D013789:Thalassemia / Q000628:therapy*
chemical_list: D003676:Deferoxamine