Protection against carbon tetrachloride-induced hepatotoxicity by protein A.
Protection from carbon tetrachloride (CCL4)-induced hepatotoxicity by protein A was assessed histologically in rats. Carbon tetrachloride exposure produced swollen, vacuolated and necrotic cells in the centrilobular region of the hepatocyte in rats. Animals given protein A prior to and during CCL1 treatment showed a complete absence of hepatic lesions. Our study showed that protein A, a potent immunomodulator, has the potential to reduce liver injury caused by carbon tetrachloride, a known hepatotoxin in the rat.
Singh
K P
KP
Preventive Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
Saxena
A K
AK
Zaidi
S I
SI
Dwivedi
P D
PD
Srivastava
S P
SP
Seth
P K
PK
Ray
P K
PK
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology / Q000517:prevention & control*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D008099:Liver / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013205:Staphylococcal Protein A / Q000627:therapeutic use*
D013205:Staphylococcal Protein A