The influence of blood donation on antibody-dependent cellular cytotoxicity (ADCC) in voluntary blood bank donors.
K cell activity by peripheral blood lymphocytes was found to be significantly decreased in voluntary blood bank donors, this decrease being particularly evident when cytotoxicity was expressed in lytic units. When blood donors were divided into groups in relation to the total amount of blood donated, the deepest decline of ADCC was found in the group of "moderate" (3-6 l of blood withdrawn) donors. A single blood donation was followed by a transient decrease in the K cell activity and returned to normal values in about two months.
Lasek
W
W
Department of Transplantology, Histology and Embryology, Institute of Biostructure, Medical School, Warsaw, Poland.
Jakóbisiak
M
M
Płodziszewska
M
M
Górecki
D
D
D000328:Adult; D000920:Antibody-Dependent Cell Cytotoxicity; D001782:Blood Donors; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D008875:Middle Aged