title: Effects of pentobarbital and cyproheptadine on brain ischemia induced by bilateral occlusions of carotid arteries and vertebral arteries of second cervical vertebra in rats.
abstract: The bilateral hemispheric ischemia in rats was induced by the occlusion of bilateral common carotid arteries after permanent electrocauterization of bilateral vertebral arteries at the level of the second cervical vertebra. In ischemic rats, (a) electroencephalograms became flat immediately after occlusion of carotid arteries, and (b) mortalities reached maximum levels at day 3 after recirculation. These results suggested that a constant level of cerebral ischemia was produced in this rat model. Pentobarbital markedly inhibited the mortality in these ischemic rats, whereas cyproheptadine did not.
authors.affiliation: Biological Science Department, Hoechst Japan, Ltd., Saitama.
authors.forename: K
authors.initials: K
authors.lastname: Sugio
authors.forename: N
authors.initials: N
authors.lastname: Horigome
authors.forename: T
authors.initials: T
authors.lastname: Inami
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Sakurai
authors.forename: M
authors.initials: M
authors.lastname: Gotoh
authors.forename: T
authors.initials: T
authors.lastname: Sakaguchi
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D002339:Carotid Arteries / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003533:Cyproheptadine / Q000494:pharmacology*; D004569:Electroencephalography; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014711:Vertebral Artery / Q000502:physiology
chemical_list: D003533:Cyproheptadine; D010424:Pentobarbital