Fibrinolysis and peptic ulcer.
The results here presented are well correlated to previous studies showing a low activity of plasminogen activator around an ulcer, but a high activity proximally to this has not been shown before, neither that the activity is dependent on the ulcer localization. The results show low fibrinolytic activity in the mucosa after treatment with cimetidine which has not before been observed. Theoretically these results could give an idea of better effect of antifibrinolytic treatment in patients with bleeding from duodenal ulcer.
Helgstrand
U
U
D001706:Biopsy; D002927:Cimetidine / Q000627:therapeutic use; D005260:Female; D005342:Fibrinolysis; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000473:pathology* / Q000628:therapy; D010960:Plasminogen Activators / Q000378:metabolism; D014629:Vagotomy, Proximal Gastric
D002927:Cimetidine; D010960:Plasminogen Activators