title: Olsalazine-O-sulphate: an acid labile metabolite of olsalazine.
abstract: The discovery of an acid labile metabolite of olsalazine, tentatively identified as olsalazine-O-sulphate, is described. Due to its acid labile properties, this conjugate was previously co-determined with olsalazine. Based on this finding, a new assay has been developed making it possible to determine both olsalazine and olsalazine-O-sulphate simultaneously. The initial aim of this study was to simplify an original analytical method in order to improve sample throughput without loss of sensitivity. However, during this work, a previously unidentified acid labile metabolite was discovered. The characterization of this metabolite is described here.
authors.affiliation: Department of Bioanalysis and Kinetics, Pharmacia Health Care Group, Uppsala, Sweden.
authors.forename: N O
authors.initials: NO
authors.lastname: Ahnfelt
authors.forename: H
authors.initials: H
authors.lastname: Agback
mesh_terms: D000636:Aminosalicylic Acids / Q000032:analysis* / Q000302:isolation & purification / Q000378:metabolism* / Q000627:therapeutic use; D002853:Chromatography, Liquid; D003093:Colitis, Ulcerative / Q000188:drug therapy; D006801:Humans
chemical_list: D000636:Aminosalicylic Acids; C058659:olsalazine-O-sulfate; C032587:olsalazine