Adjuvant effects of beta-adrenergic drugs in the indomethacin treatment of highly lethal endotoxic shock.
Indomethacin reduced the mortality of highly lethal endotoxic shock and dopamine infusion following indomethacin treatment reduced the lethality further. However, dopamine alone did not reduce the lethality. Dobutamine or isoproterenol was not effective in the treatment of endotoxic shock with or without indomethacin treatment.
Goto
M
M
Department of Pediatrics, Loyola University of Chicago Stritch School of Medicine, Maywood, Illinois 60153.
Griffin
A J
AJ
D000818:Animals; D004280:Dobutamine / Q000627:therapeutic use; D004298:Dopamine / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007213:Indomethacin / Q000627:therapeutic use*; D007545:Isoproterenol / Q000627:therapeutic use; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic / Q000188:drug therapy*
D004280:Dobutamine; D007545:Isoproterenol; D004298:Dopamine; D007213:Indomethacin