Immunopharmacological studies on picrorhiza kurroa Royle-Ex-Benth. Part V: Anti-inflammatory action: relation with cell types involved in inflammation.
Relative importance of various cells involved in inflammation and in anti-inflammatory action of P. kurroa extract (PK) was investigated in albino rats. Effects of chemical depletion of macrophages and polymorphs and a functional deprivement of mast cells and platelets were examined on carrageenin induced pedal inflammation as well as on anti-inflammatory effect of PK treatment in this test. Such depletions/functional deprivements altered the inflammatory response in conformity with the known role of these cells. The anti-inflammatory effect of PK treatment was counteracted at 1 hr, 3 hr and 5 hr post-insult intervals by mast cell, neutrophil and macrophage depletion respectively. Manipulation of platelets was without effect.
Pandey
B L
BL
Department of Pharmacology, Banaras Hindu University, Varanasi.
Das
P K
PK
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D002462:Cell Membrane / Q000276:immunology; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010936:Plant Extracts / Q000276:immunology / Q000494:pharmacology*; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D002351:Carrageenan