Behavioral effects of angiotensin II and angiotensin II-(4-8)-pentapeptide in rats.
One nM of angiotensin II (AII) or angiotensin II-(4-8)-pentapeptide [AII(4-8)] given intracerebroventricularly did not affect locomotor and exploratory behavior of rats in open field. AII significantly increased and AII(4-8) did not affect vertical activity of animals in electromagnetic motimeter. Neither of the peptides influenced horizontal activity in the motimeter. Both peptides intensified stereotypy produced by apomorphine and amphetamine. AII significantly improved, while AII(4-8) did not affect, consolidation of memory of the correct way to food in T-maze. Similarly, AII increased and AII(4-8) did not change the rate of acquisition of conditioned avoidance responses in a shuttle-box. Of the two examined peptides only AII significantly improved retrieval of memory of the passive avoidance behavior. The results show that AII(4-8) influences central dopaminergic system but, unlike its parent peptide AII, has no apparent effect on memory.
Braszko
J J
JJ
Department of Pharmacology, Medical Academy, Bialystok, Poland.
WŁasienko
J
J
Kupryszewski
G
G
Witczuk
B
B
Wisniewski
K
K
D000809:Angiotensins / Q000494:pharmacology*; D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects; D001143:Arousal / Q000187:drug effects; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D004193:Discrimination Learning / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D009042:Motivation / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects
D000809:Angiotensins; D010446:Peptide Fragments; C022782:angiotensin pentapeptide