title: Use of the maximum likelihood method in the analysis of chamber air dives.
abstract: The method of maximum likelihood was used to evaluate the risk of decompression sickness (DCS) for selected chamber air dives. The parameters of two mathematical models for predicting DCS were optimized until the best agreement (as measured by maximum likelihood) corresponding to the observed DCS incidents from a series of dives was attained. The decompression data used consisted of 800 man-dives with 21 incidents of DCS and 6 occurrences of marginal symptoms. The first model investigated was based on a nonlinear gas exchange in a series arrangement of four compartments. The second model was based on a monoexponential gas exchange in a parallel arrangement of two compartments. The overall statistical success in describing the 800 man-dives was quite similar for the two models. Predictions of safety for dives not part of the original data differed for the models due to differences in gas kinetics. For short, no-decompression dives, the series arrangement of compartments predicted a lower incidence of DCS. These predictions were more consistent with the outcome of subsequent testing than were predictions of the parallel compartment model. Predictions of the series arrangement model were also similar to those of a single-compartment, two-exponential model that was evaluated with over 1700 man-dives by the U.S. Navy.
authors.affiliation: Defence and Civil Institute of Environmental Medicine, Downsview, Ontario, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Tikuisis
authors.forename: R Y
authors.initials: RY
authors.lastname: Nishi
authors.forename: P K
authors.initials: PK
authors.lastname: Weathersby
mesh_terms: D003665:Decompression Sickness / Q000453:epidemiology*; D008954:Models, Biological; D012307:Risk Factors