title: Extracellular Ca2+ and retinal spreading depression.
abstract: The present study focuses on the influence of changes in extracellular Ca2+ on retinal spreading depression in vitro. It shows that changes in Ca2+ concentration alter the speed of the reaction. This effect is more pronounced for variations occurring within limits close to the physiological concentration level. The experiments also indicate that if the tissue is initially exposed to a lowered extracellular Ca2+ concentration, then the effects of transient variation in Ca2+ are significantly enhanced. Finally, a synergistic action of Ca2+ and K+ is observed with respect to the spreading of the reaction.
authors.affiliation: Departamento de Neurobiologia, Universidade Federal do Rio de Janeiro, Brasil.
authors.forename: R J
authors.initials: RJ
authors.lastname: Do Carmo
authors.forename: H
authors.initials: H
authors.lastname: Martins-Ferreira
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D002645:Chickens; D013181:Cortical Spreading Depression / Q000187:drug effects*; D066298:In Vitro Techniques; D007552:Isotonic Solutions; D010857:Pigment Epithelium of Eye / Q000187:drug effects; D011188:Potassium / Q000378:metabolism; D000077331:Ringer's Solution
chemical_list: D007552:Isotonic Solutions; D000077331:Ringer's Solution; D011188:Potassium; D002118:Calcium