title: [The effect of amniocentesis on pregnancy prolongation in patients of threatened premature labor with intact membranes].
abstract: The effects of amniocentesis on the prolongation of the gestational period was retrospectively reviewed in patients, in premature labor with intact membranes between 24 and 36 weeks of gestation. Amniocentesis was performed on 55 patients (study group) to evaluate fetal lung maturity and to detect subclinical intraamniotic infection, while the remaining 170 patients (control group) did not receive this procedure. Isoxsuprine was used as the primary tocolytic agent in all the patients. There was no difference in the incidence of spontaneous rupture of the membranes during tocolysis (3/55 vs. 7/170), cesarean deliveries (3/55 vs. 10/170), and adjunctive use of magnesium sulfate with isoxsuprine (11/55 vs. 31/170). A statistical analysis of the time interval from amniocentesis to vaginal delivery at each score of the tocolysis index failed to show any evidence that amniocentesis might induce labor. Moreover, no maternal or neonatal morbidity was attributable to amniocentesis. These data suggest that the use of amniocentesis may be a helpful procedure in the management of premature labor with intact membranes with minimum effect on the outcome of the clinical course.
authors.affiliation: Perinatal Medical Center, Kagoshima Municipal Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuda
authors.forename: T
authors.initials: T
authors.lastname: Ikenoue
authors.forename: M
authors.initials: M
authors.lastname: Kamitomo
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Hokanishi
mesh_terms: D000328:Adult; D000649:Amniocentesis; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D006801:Humans; D007556:Isoxsuprine / Q000494:pharmacology; D007752:Obstetric Labor, Premature; D011247:Pregnancy; D011255:Pregnancy Maintenance; D012189:Retrospective Studies
chemical_list: D007556:Isoxsuprine