Inhibition of ConA-induced proliferative response in human lymphocytes by podophyllotoxin and a detergent, Tween80.
Podophyllotoxin (CPH86), at concentrations of 5 ng/ml or more, inhibited [3H]-thymidine uptake of ConA-induced proliferation of human peripheral mononuclear blood cells. Tween80, the detergent included in the anti-inflammatory drug Proresid, containing podophyllum lignan derivatives, also inhibited lymphocyte proliferation in a dose-dependent manner. Combination of the two drugs did not, or did only weakly, potentiate the inhibitory effect of each drug.
Månsson
B
B
Department of Rheumatology, University Hospital, Lund, Sweden.
Geborek
P
P
Hallberg
T
T
Sturfelt
G
G
D003208:Concanavalin A / Q000037:antagonists & inhibitors*; D004357:Drug Synergism; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D011034:Podophyllotoxin / Q000494:pharmacology*; D011136:Polysorbates / Q000494:pharmacology
D011136:Polysorbates; D003208:Concanavalin A; D011034:Podophyllotoxin