[Study of the nonspecific effect of phosphocreatine disodium salt on the process of excitation conduction in acute myocardial ischemia].
The effect of phosphocreatine and phosphocreatinine disodium salts on excitation conduction in acute myocardial ischemia was investigated, using repeated short-term ischemia exposures of the isolated rabbit ventricular septum as a model. Considerable improvement of excitation conduction through ischemized myocardium, seen after the administration of phosphocreatine and phosphocreatinine salts, was shown to be associated with Na+ added to the perfusion medium. Phosphocreatine and phosphocreatinine effects on excitation conduction time and the septal force in control perfusion were related to both the addition of Na+ and the binding of Ca2+ by these agents in the perfusion medium.
Rozenshtraukh
L V
LV
Fleĭdervish
I A
IA
Undrovinas
A I
AI
Paiu
A Iu
AIu
D000208:Acute Disease; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000517:prevention & control*; D002118:Calcium / Q000494:pharmacology; D003327:Coronary Disease / Q000503:physiopathology*; D003470:Culture Media; D004558:Electric Stimulation; D006329:Heart Conduction System / Q000187:drug effects / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D010725:Phosphocreatine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011817:Rabbits; D012964:Sodium / Q000494:pharmacology
D003470:Culture Media; D010725:Phosphocreatine; C025403:phosphocreatinine; D012964:Sodium; D002118:Calcium
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