title: Transient hyperkalaemia immediately after acute haemorrhage in rats.
abstract: The effect of haemorrhage on plasma potassium concentration was studied in Sprague-Dawley rats, Brattleboro (BDI) rats and the parent strain Long-Evans (LE) rats. Haemorrhage induced an increase in plasma potassium within 10 min in all rats studied; 20 and 30 min later, plasma potassium was back to prehaemorrhage level. Changes in plasma sodium concentration were not statistically significant. When haemorrhage (1.0% of body weight) was repeated in the same animal preparation, there was a further significant increase in plasma potassium, but a fall in plasma sodium concentration. When vasopressin was injected intravenously, plasma potassium concentration did not change significantly (-0.21 +/- 0.21 mmol/l) in LE rats, whilst it increased significantly (0.69 +/- 0.20 mmol/l, p less than 0.001; paired t-test) in the BDI rats. The results suggest that haemorrhage-induced hyperkalaemia is unrelated to vasopressin, despite the fact that it increases plasma potassium concentration in the BDI rats when injected.
authors.affiliation: Department of Physiology, University of Ilorin, Kwara State, Nigeria.
authors.forename: L F
authors.initials: LF
authors.lastname: Obika
mesh_terms: D000818:Animals; D006439:Hemodynamics; D006470:Hemorrhage / Q000150:complications*; D006947:Hyperkalemia / Q000209:etiology*; D008297:Male; D011188:Potassium / Q000097:blood; D051381:Rats; D011910:Rats, Brattleboro; D011919:Rats, Inbred Strains; D012964:Sodium / Q000097:blood; D013045:Species Specificity; D014667:Vasopressins / Q000494:pharmacology*
chemical_list: D014667:Vasopressins; D012964:Sodium; D011188:Potassium