title: Antibacterial activity of selected tropones and tropolones.
abstract: The antibacterial activity of 33 substituted and unsubstituted seven-member ring tropones and tropolones was examined on 14 reference strains representing Gram-positive and Gram-negative bacteria. It was shown that the chemical character and position of the substituent plays a distinct role in the biological activity of investigated compounds. Depending on the substituent the antibacterial effect may be either increased or diminished. C-1 thio and C-2 nitro derivatives of tropone are significantly more active than tropone. The dibenzotropone derivatives display no antibacterial activity. Hydroxymethyl derivatives of tropolone are more active than tropolone, while hydroxy-, isopropyl-, methyl- as well as tropolone acetates are equipotent.
authors.affiliation: Department of Microbiology, Polish Academy of Sciences, Wroclaw.
authors.forename: N A
authors.initials: NA
authors.lastname: Saleh
authors.forename: A
authors.initials: A
authors.lastname: Zwiefak
authors.forename: M
authors.initials: M
authors.lastname: Mordarski
authors.forename: G
authors.initials: G
authors.lastname: Pulverer
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003508:Cycloheptanes / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D015394:Molecular Structure; D014334:Tropolone / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D003508:Cycloheptanes; D014334:Tropolone