title: Concentration-effect relationships with carbamazepine and its epoxide on psychomotor and cognitive function in epileptic patients.
abstract: A battery of psychometric tests was administered to 85 patients with epilepsy, of whom 26 were untreated, 40 received carbamazepine monotherapy and 19 took carbamazepine with another anticonvulsant. Carbamazepine alone had little effect on performance, but carbamazepine polypharmacy produced significant impairment. Increasing concentrations of carbamazepine (four tests) and its active metabolite, carbamazepine 10,11 epoxide (seven tests), correlated with decreasing performance in the monotherapy patients.
authors.affiliation: Department of Clinical Psychology, Southern General Hospital, Glasgow, Scotland.
authors.forename: R A
authors.initials: RA
authors.lastname: Gillham
authors.forename: N
authors.initials: N
authors.lastname: Williams
authors.forename: K
authors.initials: K
authors.lastname: Wiedmann
authors.forename: E
authors.initials: E
authors.lastname: Butler
authors.forename: J G
authors.initials: JG
authors.lastname: Larkin
authors.forename: M J
authors.initials: MJ
authors.lastname: Brodie
mesh_terms: D000328:Adult; D002220:Carbamazepine / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000187:drug effects*; D019966:Substance-Related Disorders / Q000209:etiology*
chemical_list: D002220:Carbamazepine; C012227:carbamazepine epoxide