title: Disposition of phenytoin and phenobarbitone in the isolated perfused human placenta.
abstract: 1. The disposition of the anti-epileptic agents phenytoin (PHT) and phenobarbitone (PB) was investigated in lobules of term human placentae perfused using separate maternal and fetal circulations for 6 h periods. 2. No evidence for metabolism of PHT or PB to their p-hydroxylated or other derivatives was found either in perfused lobules or by incubation with placental microsomes. 3. Both PHT and PB were readily transferred across the placenta after administration to either the maternal or fetal perfusates. 4. PHT, unlike PB, showed considerable accumulation in placental tissue.
authors.affiliation: Department of Medicine, University of Queensland, Royal Brisbane Hospital, Australia.
authors.forename: R M
authors.initials: RM
authors.lastname: Kluck
authors.forename: G R
authors.initials: GR
authors.lastname: Cannell
authors.forename: W D
authors.initials: WD
authors.lastname: Hooper
authors.forename: M J
authors.initials: MJ
authors.lastname: Eadie
authors.forename: R G
authors.initials: RG
authors.lastname: Dickinson
mesh_terms: D001711:Biotransformation; D002250:Carbon Radioisotopes; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D010477:Perfusion; D010634:Phenobarbital / Q000378:metabolism / Q000493:pharmacokinetics*; D010672:Phenytoin / Q000378:metabolism / Q000493:pharmacokinetics*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D002250:Carbon Radioisotopes; D010672:Phenytoin; D010634:Phenobarbital