Why does RU486 fail to prevent implantation despite success in inducing menstruation?
The administration of RU38486 (RU486) in the luteal phase may induce menstruation, but it may not be associated with shedding of the functional layer of the endometrium. This provides an explanation why, in some cases of successful menstrual induction by RU486, pregnancy continues undisturbed. The ability of RU486 to interrupt a very early pregnancy is more likely to be related to its ability to cause shedding of the endometrium than its ability to induce menstruation.
Li
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Department of Obstetrics and Gynaecology, University of Sheffield, England.
Lenton
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EA
Dockery
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P
Rogers
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AW
Cooke
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ID
D000328:Adult; D010064:Embryo Implantation / Q000187:drug effects*; D004717:Endometrium / Q000187:drug effects; D004963:Estrenes / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008598:Menstruation / Q000187:drug effects*; D015735:Mifepristone; D011247:Pregnancy
D004963:Estrenes; D015735:Mifepristone