title: A new type of transforming growth factor-beta, TGF-beta 3.
abstract: A new type of TGF-beta, TGF-beta 3, has been identified by cDNA characterization. The amino acid sequence of mature TGF-beta 3 and its precursor has been derived from porcine and human cDNA sequences. The human TGF-beta 3 gene is spread over seven exons as in the case of the TGF-beta 1 gene. Comparison with TGF-beta 1 and -beta 2 indicates a strong conservation of the mature sequences, but a relaxed homology in the precursor segments. TGF-beta 3 mRNA is mainly expressed in cell lines from mesenchymal origin, suggesting a biological role different from the other TGFs-beta.
authors.affiliation: Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080.
authors.forename: R
authors.initials: R
authors.lastname: Derynck
authors.forename: P B
authors.initials: PB
authors.lastname: Lindquist
authors.forename: A
authors.initials: A
authors.lastname: Lee
authors.forename: D
authors.initials: D
authors.lastname: Wen
authors.forename: J
authors.initials: J
authors.lastname: Tamm
authors.forename: J L
authors.initials: JL
authors.lastname: Graycar
authors.forename: L
authors.initials: L
authors.lastname: Rhee
authors.forename: A J
authors.initials: AJ
authors.lastname: Mason
authors.forename: D A
authors.initials: DA
authors.lastname: Miller
authors.forename: R J
authors.initials: RJ
authors.lastname: Coffey
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005796:Genes; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D013552:Swine; D015291:Transforming Growth Factors / Q000145:classification* / Q000235:genetics
chemical_list: D011498:Protein Precursors; D012333:RNA, Messenger; D015291:Transforming Growth Factors; D004247:DNA