Modulation of lemniscal input during conditioned arm movements in the monkey.
Modulation of sensory transmission in the lemniscal system was investigated in 2 monkeys trained to perform a simple elbow flexion in response to an auditory cue. Evoked responses to peripheral stimulation were recorded in the medial lemniscus, sensory thalamus (ventral posterior lateral nucleus, caudal division, VPLc) and somatosensory cortex. Simultaneous recordings were made from the cortex and either the medial lemniscus or VPLc. At all recording sites, evoked responses to natural (air puff) or electrical, percutaneous stimulation were depressed prior to and during active movement. The time course of the depression was similar at all three levels; the magnitude of the decrease during movement was most pronounced at the cortical level. Cortical evoked responses to central stimulation of effective sites in either the medial lemniscus or VPLc were decreased during, but not before, the onset of movement. The decrease was less than that seen for peripheral evoked potentials. Passive movement of the forearm significantly decreased all but the lemniscal evoked potential. The results indicate that there is a centrally mediated suppression of somatosensory transmission prior to, and during movement, occurring at the level of the first relay, the dorsal column nuclei. During movement, reafferent signals from the moving arm decrease transmission at the thalamocortical level.
Chapman
C E
CE
Centre de Recherche en Sciences Neurologiques, Université de Montréal, Québec, Canada.
Jiang
W
W
Lamarre
Y
Y
D000818:Animals; D003213:Conditioning, Psychological; D004558:Electric Stimulation; D005542:Forearm / Q000294:innervation; D008251:Macaca / Q000502:physiology*; D008252:Macaca fascicularis / Q000502:physiology*; D008253:Macaca mulatta / Q000502:physiology*; D009043:Motor Activity; D009068:Movement; D009132:Muscles / Q000294:innervation*; D012867:Skin / Q000294:innervation*; D013003:Somatosensory Cortex / Q000502:physiology*