Carnitine supplementation vs. medium-chain triglycerides in postburn nutritional support.
The effect of dietary supplementation of carnitine on protein metabolism was studied in a burned guinea-pig model. Animals bearing a 30 per cent total body surface area burn were enterally infused with three isocaloric and isonitrogenous diets via gastrostomy feeding tubes for 14 days. Two diets contained safflower oil (long-chain triglycerides, LCT) and another diet contained medium-chain triglycerides (MCT) as their lipid sources (30 per cent of total calories as lipid). L-Carnitine was added to one of the two diets containing safflower oil. There were no significant differences in nitrogen balance, urinary excretion, serum albumin or transferrin among the three groups. However, the use of MCT in place of LCT appeared to increase liver weight and liver nitrogen. In this model, carnitine supplementation did not enhance the nitrogensparing effect of fat following burn injury.
Trocki
O
O
Shriners Burns Institute, Cincinnati, Ohio.
Heyd
T J
TJ
Alexander
J W
JW
Robb
E C
EC
Waymack
J P
JP
Gura
P
P
D000818:Animals; D002056:Burns / Q000150:complications*; D002331:Carnitine / Q000097:blood / Q000627:therapeutic use* / Q000652:urine; D004032:Diet; D006168:Guinea Pigs; D008055:Lipids / Q000032:analysis; D009748:Nutrition Disorders / Q000178:diet therapy*; D011506:Proteins / Q000378:metabolism*; D014280:Triglycerides / Q000627:therapeutic use*
D008055:Lipids; D011506:Proteins; D014280:Triglycerides; D002331:Carnitine