Immune stimulation. A new approach in the treatment of glomerulonephritis.
We discuss here a new approach to the treatment of idiopathic membranous glomerulonephritis (IMGN). Steroids and cytotoxic drugs have been used during the last years for the treatment of this disease, but the results are controversial. We develop here the hypothesis that the pathogenesis of IMGN is a relative incompetence of the immune system in clearing foreign antigens. Therefore, most patients should benefit from immune stimulation in the direction of a greater and more avid immune response.
Rotellar
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Georgetown Hospital, Washington, D.C. 20007.
Rakowski
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D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000936:Antigen-Antibody Complex; D015433:Glomerulonephritis, Membranous / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D007978:Levamisole / Q000627:therapeutic use; D008954:Models, Biological
D000276:Adjuvants, Immunologic; D000936:Antigen-Antibody Complex; D007978:Levamisole