title: Pure pancreatic juice in humans: orange-lemon-juice-induced secretory effects. Comparative analysis with a regular meal, sorbitol, acidified peptone broth and secretin.
abstract: The secretory effect elicited by the ingestion of 100 ml of orange-lemon juice (O.-L.J.) was studied on pure pancreatic juice obtained from a catheter placed in the human Wirsung duct at surgery. These changes were compared with those evoked by a regular meal (R.M.), the ingestion of a Sorbitol solution (S.S.), the intragastric infusion of an acidified peptone broth (A.P.B.) and an i.v. single injection of secretin (Boots, 1.0 U/kg). The O.-L.J. induced purer pancreatic secretion response (flow, bicarbonate and enzyme output) than that triggered by the R.M., S.S. and A.P.B. The O.-L.J. evoked peak values, were observed earlier (60 min) than with a R.M. (90 min) ingestion. The 120-min-cumulative values confirmed these findings and disclosed that O.-L.J. elicits a rate of secretion and bicarbonate output closely similar to that of an i.v. secretin injection and amylase response greater than that evoked by this hormone. Thus, O.-L.J. ingestion proved to be an unexpected powerful stimulus of exocrine pancreatic secretion.
authors.affiliation: Gastroenerologic Unit, Hospital de Clinicas (Universidad de Buenos Aires), Argentina.
authors.forename: O M
authors.initials: OM
authors.lastname: Tiscornia
authors.forename: M A
authors.initials: MA
authors.lastname: Cresta
authors.forename: D
authors.initials: D
authors.lastname: Celener
authors.forename: G
authors.initials: G
authors.lastname: Negri
authors.forename: M I
authors.initials: MI
authors.lastname: Vaccaro
authors.forename: H
authors.initials: H
authors.lastname: Waisman
authors.forename: L
authors.initials: L
authors.lastname: Bustos Fernandez
authors.forename: D A
authors.initials: DA
authors.lastname: Dreiling
mesh_terms: D000328:Adult; D000368:Aged; D002957:Citrus; D004435:Eating; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010189:Pancreatic Juice / Q000187:drug effects / Q000378:metabolism*; D010461:Peptones / Q000494:pharmacology*; D012633:Secretin / Q000494:pharmacology*; D013012:Sorbitol / Q000494:pharmacology*
chemical_list: D010461:Peptones; D012633:Secretin; D013012:Sorbitol