title: Erythema multiforme is associated to HLA-Aw33 and DRw53.
abstract: Erythema multiforme is an acute eruption of the skin and mucous membranes of various aetiologies. Forty-one unrelated patients were HLA typed for 53 specificities of the HLA-A, B, C, DR and DQ series. Frequencies of Aw33 and DRw53 were significantly increased: Aw33, 17.0% in patients vs 2.8% in controls (corrected p = 0.01, relative risk = 7.2); DRw53, 70.7% in patients vs 30.5% in controls (corrected p = 0.0005, relative risk = 5.5).
authors.affiliation: Laboratoire d'Immunologie et d'Histocompatibilité, Hôpital Saint Louis, France.
authors.forename: V
authors.initials: V
authors.lastname: Lepage
authors.forename: C
authors.initials: C
authors.lastname: Douay
authors.forename: C
authors.initials: C
authors.lastname: Mallet
authors.forename: O
authors.initials: O
authors.lastname: Binet
authors.forename: F
authors.initials: F
authors.lastname: Lemarchand
authors.forename: D
authors.initials: D
authors.lastname: Wallach
authors.forename: M
authors.initials: M
authors.lastname: Masset
authors.forename: J
authors.initials: J
authors.lastname: Colombani
authors.forename: L
authors.initials: L
authors.lastname: Degos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004892:Erythema Multiforme / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D059845:HLA-DRB4 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype
chemical_list: D015234:HLA-A Antigens; C082945:HLA-A*33 antigen; D006684:HLA-DR Antigens; C050610:HLA-DR53; D059845:HLA-DRB4 Chains