Pacemakers in aggregation fields of Dictyostelium discoideum: does a single cell suffice?
In this paper we address the following question: can a single cell of the cellular slime mold Dictyostelium discoideum serve as a pacemaker for the aggregation phase? Whether or not this is possible is determined by the relative importance of cyclic AMP production due to self-stimulation as compared to diffusion of cyclic AMP away from the cell and extracellular degradation. We determine the conditions under which a single cell on an infinite place can emit periodic signals of cyclic AMP using a model developed previously for signal relay and adaptation in Dictyostelium. Elsewhere it has been shown that this model provides an accurate representation of the stimulus-response behavior of Dictyostelium for a variety of experimental conditions.
DeYoung
G
G
Department of Mathematics, University of Utah, Salt Lake City 84112.
Monk
P B
PB
Othmer
H G
HG
D002449:Cell Aggregation; D004023:Dictyostelium / Q000166:cytology / Q000502:physiology*; D008433:Mathematics; D008954:Models, Biological