title: Roxithromycin and controlled release theophylline, an interaction study.
abstract: A clinical trial, involving 16 male subjects affected by a relapse of chronic bronchitis, was performed in order to evaluate the possible interference of roxithromycin (RU 28965) with theophylline plasma levels. Theophylline was administered to patients as a controlled release formulation. Results did not show any clinically relevant change in theophylline blood levels, implying the conclusion that the new macrolide roxithromycin can be administered simultaneously with a controlled release theophylline.
authors.affiliation: Pneumology Dept., Ospedale Civile, Varese, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bandera
authors.forename: M
authors.initials: M
authors.lastname: Fioretti
authors.forename: R
authors.initials: R
authors.lastname: Rimoldi
authors.forename: A
authors.initials: A
authors.lastname: Lazzarini
authors.forename: M
authors.initials: M
authors.lastname: Anelli
mesh_terms: D000328:Adult; D001991:Bronchitis / Q000188:drug therapy / Q000378:metabolism*; D003692:Delayed-Action Preparations; D004347:Drug Interactions; D006801:Humans; D007933:Leucomycins / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D003692:Delayed-Action Preparations; D007933:Leucomycins; D013806:Theophylline