title: Linkage relationships of seven enzyme and two pigmentation loci in the snail Biomphalaria glabrata.
abstract: Crossing experiments with inbred stocks of the snail (Biomphalaria glabrata) demonstrated that variants at two loci determining pigmentation and seven enzyme-determining loci exhibited normal Mendelian segregation ratios in F2 progeny. Among 39 pairwise comparisons for joint segregation, there was evidence of genetic linkage between a locus controlling mantle pigmentation (S) and 6-phosphogluconate dehydrogenase (Pgd) and confirmation of a previously described linkage between esterase-2 (Est-2) and catalase (Cat). Recombination fractions were estimated to be 17 +/- 4 for S-Pgd and 33 +/- 5 for Est-2-Cat. The remaining five loci--Acon-1, Pgm-1, Lap-1, Lap-2, and Pgd--assorted independently. This brings to 17 the number of loci examined for segregation and assortment in this medically important species. As Biomphalaria has a chromosome number n = 18, markers should soon be available for most or all of the linkage groups.
authors.affiliation: Savannah River Ecology Laboratory, Aiken, SC 29801.
authors.forename: M
authors.initials: M
authors.lastname: Mulvey
authors.forename: D S
authors.initials: DS
authors.lastname: Woodruff
authors.forename: M P
authors.initials: MP
authors.lastname: Carpenter
mesh_terms: D000818:Animals; D001700:Biomphalaria / Q000201:enzymology / Q000235:genetics*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004798:Enzymes / Q000235:genetics; D008040:Genetic Linkage; D010858:Pigmentation / Q000235:genetics*
chemical_list: D004798:Enzymes