title: A case of hypopituitarism due to granulomatous and lymphocytic adenohypophysitis with minimal pituitary enlargement: a possible variant of lymphocytic adenohypophysitis.
abstract: A 47-year-old woman complaining of cold intolerance, general weakness and amenorrhea of 10 months duration was diagnosed, by endocrine examinations, as having panhypopituitarism. Skull x-ray films revealed a slightly enlarged sella with double floor sign and MRI showed a low intensity mass in the pituitary. Transsphenoidal exploration disclosed a degenerated pituitary gland, the histology of which showed a granulomatous lesion with moderate lymphocytic infiltration but containing no multinuclear giant cells. No caseous necrosis, causative microorganisms, or BCG antigen were noted. The present case is considered a variant form of lymphocytic adenohypophysitis.
authors.affiliation: 2nd Division of Internal Medicine, Kyoto University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Miyamoto
authors.forename: H
authors.initials: H
authors.lastname: Sugawa
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: N
authors.initials: N
authors.lastname: Hashimoto
authors.forename: H
authors.initials: H
authors.lastname: Imura
mesh_terms: D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000175:diagnosis / Q000209:etiology*; D007249:Inflammation / Q000150:complications; D008875:Middle Aged; D010900:Pituitary Diseases / Q000150:complications*; D010903:Pituitary Gland, Anterior / Q000473:pathology* / Q000503:physiopathology