Robertsonian heterozygosity and male sterility.
Meiotic and synaptonemal complex studies using electron microscopy were carried out on infertile man with a 13/14 translocation. Synaptonemal complex analysis showed a typical trivalent with incomplete pairing of the acrocentric elements. The sterilizing effect caused by the failure of synapsis is discussed. This pairing failure has a diagnostic value and a poor prognosis.
Gabriel-Robez
O
O
Faculté de Médicine, Institute d'Embryology, Strasbourg/France.
Ratomponirina
C
C
Cranz
C
C
Weill
A
A
Goldschmit
P A
PA
Bollack
C
C
Rumpler
Y
Y
D000328:Adult; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D006579:Heterozygote; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008854:Microscopy, Electron; D008938:Mitosis; D011379:Prognosis; D014178:Translocation, Genetic