title: New methods of quantitative assessment of the extent and significance of serial ECG changes of the repolarization phase.
abstract: The authors present a method for optimally measuring variations in T wave shape and time intervals for the quantitative assessment of the significance of serial changes of the repolarization phase. The results, established on a healthy population, show the inadequacy of Bazett's formula, the constancy of maximum of T to the end of the T time interval, and good stability of the spatial T loops' morphotype. Residual intrasubject variability of corrected QT interval is mainly ascribable to physiologic, heart rate-independent changes in true onset of Q to a maximum of T time interval. The optimized mean quadratic deviation between two serial T loops is well correlated with changes in drug concentration.
authors.affiliation: Institut National des Sciences Appliquées Département Informatique, Villeurbanne, France.
authors.forename: P
authors.initials: P
authors.lastname: Rubel
authors.forename: J
authors.initials: J
authors.lastname: Fayn
authors.forename: N
authors.initials: N
authors.lastname: Mohsen
authors.forename: P
authors.initials: P
authors.lastname: Girard
mesh_terms: D000328:Adult; D000465:Algorithms; D004562:Electrocardiography; D006339:Heart Rate; D006801:Humans; D008297:Male; D010806:Physical Education and Training; D011802:Quinidine / Q000494:pharmacology; D012815:Signal Processing, Computer-Assisted; D012984:Software; D014672:Vectorcardiography
chemical_list: D011802:Quinidine