Fragile site in chromosome 12 in a patient with two miscarriages.
A heritable fragile site at 12q13 is described in lymphocytes from a woman with a history of multiple miscarriage. The fragile site was not typically folate-sensitive, being expressed in standard medium. The presence of this fragile site may have led to meiotic chromosome breakage and consequent infertility.
Stetten
G
G
Department of Gynecology and Obstetrics, Johns Hopkins University, Baltimore, Maryland 21205.
Sroka
B
B
Norbury-Glaser
M
M
Corson
V L
VL
D000026:Abortion, Habitual / Q000209:etiology*; D000328:Adult; D002869:Chromosome Aberrations / Q000150:complications*; D025063:Chromosome Disorders; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002881:Chromosomes, Human, Pair 12; D004305:Dose-Response Relationship, Drug; D005260:Female; D005492:Folic Acid / Q000494:pharmacology; D006801:Humans; D011247:Pregnancy
D005492:Folic Acid