title: Preneoplastic lesions and prognostic factors of breast cancer.
abstract: The Authors have investigated preneoplastic lesions and the problem of the identification of benign lesions considered with or without preneoplastic potential, comparing for the occasion the presence of transformation markers in these lesions with the positivity of tumor markers in neoplastic tissue. The dosages have been valued on neoplastic tissue (180 cases), dysplastic tissue (50 cases), on cystic fluid (70 cases), and on nipple discharge (80 cases). The data obtained show a marked positivity to the tumor markers and the ionic and hormonal content (K+, Na+ DHEAS, PRL evaluation). The positivity of some lesions, not properly preneoplastic (or atypical) towards some markers of neoplasia could show some differences of great interest between benignity and malignity.
authors.affiliation: Gynecologic and Obstetric Clinic, University of L'Aquila, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Pozzi
authors.forename: A
authors.initials: A
authors.lastname: Pala
authors.forename: M
authors.initials: M
authors.lastname: Ermini
authors.forename: C
authors.initials: C
authors.lastname: Maschio
authors.forename: T
authors.initials: T
authors.lastname: Ventura
authors.forename: G
authors.initials: G
authors.lastname: Coletti
authors.forename: A
authors.initials: A
authors.lastname: Vecchione
authors.forename: M P
authors.initials: MP
authors.lastname: Nusiner
authors.forename: S
authors.initials: S
authors.lastname: Luciani
authors.forename: L
authors.initials: L
authors.lastname: Carenza
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005260:Female; D006801:Humans; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor