Liposome-bound cyclosporine: retinal toxicity after intravitreal injection.
The retinal toxicity of intraocular liposome-bound cyclosporine was studied in albino rabbits by means of electrophysiology and histopathology. During a followup period of one month, no histopathological or electroretinographic changes were noted using concentrations of 100, 200 and 500 micrograms injected intravitreally.
Alghadyan
A A
AA
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans.
Peyman
G A
GA
Khoobehi
B
B
Liu
K R
KR
D000818:Animals; D003524:Cyclosporins / Q000008:administration & dosage / Q000633:toxicity*; D004337:Drug Carriers; D004594:Electrophysiology; D007267:Injections; D008081:Liposomes; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors; D014822:Vitreous Body / Q000378:metabolism*
D003524:Cyclosporins; D004337:Drug Carriers; D008081:Liposomes