title: Atpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physico-chemical and biological properties.
abstract: Penicillium sp. FO-125, a soil isolate, was found to produce a new antifungal antibiotic complex named atpenin. Three components A4, A5 and B were isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and HPLC. The molecular formula of atpenins A4, A5 and B were determined to be C15H22NO5Cl, C15H21NO5Cl2 and C15H23NO5, respectively, on the basis of high resolution electron impact mass spectrometry and elemental analysis. They are active against filamentous fungi, especially, Trichophyton sp.
authors.affiliation: Kitasato Institute, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Omura
authors.forename: H
authors.initials: H
authors.lastname: Tomoda
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: D Z
authors.initials: DZ
authors.lastname: Zhen
authors.forename: H
authors.initials: H
authors.lastname: Kumagai
authors.forename: K
authors.initials: K
authors.lastname: Igarashi
authors.forename: N
authors.initials: N
authors.lastname: Imamura
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Iwai
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D010407:Penicillium / Q000145:classification / Q000378:metabolism*; D011728:Pyridones
chemical_list: D000935:Antifungal Agents; D011728:Pyridones; C058278:atpenin A5; C058277:atpenin A4; C058279:atpenin B