[Effect of synthetic analogs of the sex steroid hormones on the secretory and proliferative activity of the adenohypophysis in vivo and in vitro in rats].
Synthetic steroid compounds STS 557 and STS 737 administered to ovariectomized rats increased prolactin secretion to a lesser extent than estradiol benzoate or estrogen J 271. When injected to estradiol benzoate treated ovariectomized rats, compounds STS 557, STS 737 and progesterone failed to change DNA synthesis in the adenohypophysis and prolactin secretion. Only compound STS 737 exerted a pronounced effect on the adenohypophyseal cells in primary cultures. It inhibited DNA synthesis and prolactin secretion. These effects were synergistic with the inhibitory action of bromocriptine (CB-154) that is of certain interest for elaborating methods of treatment of pituitary hyperplasias and tumours.
Fedotov
V P
VP
Gudoshnikov
V I
VI
Kurishko
A Ia
AIa
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D004357:Drug Synergism; D004958:Estradiol / Q000494:pharmacology; D045166:Estradiol Congeners / Q000494:pharmacology*; D005260:Female; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D010052:Ovariectomy; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology; D045167:Progesterone Congeners / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
D045166:Estradiol Congeners; D045167:Progesterone Congeners; D001971:Bromocriptine; C023635:dienogest; D011374:Progesterone; D004958:Estradiol; D009277:Nandrolone; D011388:Prolactin; D004247:DNA
Izuchenie vliianiia sinteticheskikh analogov polovykh steroidnykh gormonov na sekretornuiu i proliferativnuiu aktivnost' adenogipofiza krys in vivo i in vitro.