Intra-articular apatite deposition in mixed connective tissue disease: crystallographic and technetium scanning characteristics.
An acute arthritis in a patient with mixed connective tissue disease (MCTD) was found to be associated with intra-articular deposition of carbonated hydroxyapatite crystals. A technetium hydroxymethylene diphosphonate bone scan showed intense uptake in the delayed phase scan of the affected joints. Synovial fluid analysis demonstrated uptake of the radiopharmaceutical drug directly onto the crystals.
Hutton
C W
CW
Royal National Hospital for Rheumatic Diseases, Bath.
Maddison
P J
PJ
Collins
A J
AJ
Berriman
J A
JA
D000328:Adult; D001168:Arthritis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism; D002114:Calcinosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D003461:Crystallography; D005260:Female; D006225:Hand / Q000000981:diagnostic imaging; D006801:Humans; D006882:Hydroxyapatites / Q000032:analysis*; D008947:Mixed Connective Tissue Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D011877:Radionuclide Imaging; D013582:Synovial Fluid / Q000032:analysis; D013669:Technetium Tc 99m Medronate
D006882:Hydroxyapatites; D013669:Technetium Tc 99m Medronate