VIP-, SS-, and GABA-like immunoreactivity in the mid-hippocampal region of El (epileptic) and C57BL/6 mice.
The El (epileptic) mouse is a model of hereditary sensory precipitated temporal lobe epilepsy. We compared vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI), somatostatin-like immunoreactivity (SS-LI), and gamma-aminobutyric acid-like immunoreactivity (GABA-LI) in the mid-hippocampal region of El and C57BL/6 mice. Specific interneuron populations with VIP-LI and GABA-LI were elevated in the El mice, whereas SS-LI populations were unchanged. These neurochemical alterations may be contributing to the epileptic predisposition of El mice.
King
J T
JT
Section of Neurological Surgery, Yale University School of Medicine, New Haven, CT 06510.
LaMotte
C C
CC
D000818:Animals; D004827:Epilepsy / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D007150:Immunohistochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D010455:Peptides / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D010455:Peptides; C029993:somatostatin-like peptides; D014660:Vasoactive Intestinal Peptide; D005680:gamma-Aminobutyric Acid