The relationship between changes in lipid fuel availability and tissue fructose 2,6-bisphosphate concentrations and pyruvate dehydrogenase complex activities in the fed state.
An elevated concentration of non-esterified fatty acids in the fed state elicited inhibition of cardiac, but not hepatic, pyruvate dehydrogenase complex (PDH). There was a modest decline in fructose 2,6-bisphosphate (Fru-2,6-P2) concentration in heart, and, to a lesser extent, in liver. Surgical stress decreased PDH activities and Fru-2,6-P2 concentrations in both heart and liver. Only the former response was abolished if postoperative lipolysis was inhibited. Surgery also decreased the [Fru-2,6-P2] in gastrocnemius: this response was abolished if lipolysis was inhibited.
French
T J
TJ
Surgical Unit, London Hospital, Whitechapel, U.K.
Goode
A W
AW
Holness
M J
MJ
MacLennan
P A
PA
Sugden
M C
MC
D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005260:Female; D005635:Fructosediphosphates / Q000032:analysis*; D005947:Glucose / Q000378:metabolism; D006598:Hexosediphosphates / Q000032:analysis*; D008066:Lipolysis; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D005635:Fructosediphosphates; D006598:Hexosediphosphates; D011768:Pyruvate Dehydrogenase Complex; C027652:fructose 2,6-diphosphate; D005947:Glucose