title: [Minocycline diffusion into prostatic tissue].
abstract: We evaluated the concentration of minocycline in human prostatic tissue. Twenty-six patients undergoing transurethral resection of prostate, two patients undergoing open prostatectomy for benign prostatic hyperplasia and two patients undergoing radical cystoprostatectomy for bladder cancer were studied. Prostatic tissue and blood were sampled at 1, 2 or 3 hours after the intravenous administration of 200 mg of minocycline. The concentration of minocycline was 2.95 +/- 1.39 micrograms/ml (mean +/- SD) in serum and 1.97 +/- 0.79 cg/g (mean +/- SD) in the prostatic tissue. The ratio of the prostatic concentration/serum concentration was 0.76 +/- 0.33 (mean +/- SD).
authors.affiliation: Department of Urology, Toyonaka Municipal Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Kawashima
authors.forename: W
authors.initials: W
authors.lastname: Sakamoto
authors.forename: T
authors.initials: T
authors.lastname: Nishijima
mesh_terms: D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008911:Minocycline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011467:Prostate / Q000378:metabolism*; D013754:Tetracyclines / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D013754:Tetracyclines; D008911:Minocycline