Antral mucosal bile acids in two types of chronic atrophic gastritis.
Bile acids may damage the gastric mucosa, and they are cocarcinogenic in experimental colonic and gastric cancer. Chronic atrophic gastritis (CAG) and chronic atrophic gastritis with intestinal metaplasia (CAGIM) are associated with gastric carcinoma. We, therefore, analysed bile acids in the antral mucosa in controls (n = 10), in patients with CAG (n = 12) and CAGIM (n = 20). In both forms of chronic antral gastritis, total mucosal bile acid concentrations drop, caused mainly by lower primary bile acids. The proportions of secondary bile acids rise, in particular of toxic lithocholic acid. This is probably caused by bacterial activity in the stomach. Whether secondary bile acids, especially lithocholic acid, alone or in combination with other bacterial degradation products, influence gastric carcinogenesis remains to be elucidated in further studies.
Kurtz
W J
WJ
Dept. of Gastroenterology, ZIM, University Clinics, Frankfurt/Main, West Germany.
Dikimli
A
A
Leuschner
U
U
Classen
M
M
D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000378:metabolism*; D002635:Chenodeoxycholic Acid / Q000378:metabolism; D019826:Cholic Acid; D002793:Cholic Acids / Q000378:metabolism; D003840:Deoxycholic Acid / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D005756:Gastritis / Q000378:metabolism*; D005757:Gastritis, Atrophic / Q000150:complications / Q000378:metabolism*; D006801:Humans; D007422:Intestines / Q000473:pathology; D008095:Lithocholic Acid / Q000378:metabolism; D008297:Male; D008679:Metaplasia / Q000209:etiology; D008875:Middle Aged; D011706:Pyloric Antrum; D013274:Stomach Neoplasms / Q000209:etiology; D014580:Ursodeoxycholic Acid / Q000378:metabolism
D001647:Bile Acids and Salts; D002793:Cholic Acids; D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid; C004821:muricholic acid; D008095:Lithocholic Acid; D014580:Ursodeoxycholic Acid; C010471:hyodeoxycholic acid; D019826:Cholic Acid