title: Contractile reactivity of the perfused mesenteric vascular bed from sinoaortic denervated rats to norepinephrine, methoxamine and verapamil.
abstract: The contractile reactivity to norepinephrine, methoxamine, and verapamil of the perfused mesenteric vascular bed from sinoaortic denervated (SAD) and sham-operated (SO) rats was studied 3 to 30 days after surgery. A gradual but incomplete reduction of arterial hypertension was observed in SAD rats throughout the study. The norepinephrine- and methoxamine-induced dose-response curves were similar in both SAD and SO groups on day 3, but shifted to the left on days 7 and 15 and demonstrated a tendency to shift to the right at 30 days. Verapamil-induced vasodilation was similar in both groups. Enhanced mesenteric vascular responsiveness to endogenous catecholamines could contribute to the increased vascular resistance.
authors.affiliation: Departamento de Ciências Fisiológicas, UFES, Vitória, Brasil.
authors.forename: E C
authors.initials: EC
authors.lastname: Vasquez
authors.forename: N S
authors.initials: NS
authors.lastname: Bissoli
authors.forename: M R
authors.initials: MR
authors.lastname: Moyses
authors.forename: A M
authors.initials: AM
authors.lastname: Cabral
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003714:Denervation; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects*; D008642:Mesenteric Veins / Q000187:drug effects*; D008729:Methoxamine / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012850:Sinus of Valsalva / Q000294:innervation; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D014700:Verapamil; D008729:Methoxamine; D009638:Norepinephrine