title: Efficacy of febantel against naturally acquired gastrointestinal nematodes in calves, and recognition of Oesophagostomum venulosum in Oregon cattle.
abstract: The efficacy of febantel (5.0 mg/kg) against naturally acquired infections of gastrointestinal nematodes was evaluated in a controlled test in calves during the winter. Twenty steers were allotted to either control or treatment groups of 10 animals each. Seven days after treatment, calves were euthanatized and necropsied for recovery of parasites. Febantel was highly effective against adults of Ostertagia spp (88.6% efficacy based on median), Cooperia spp (97.7%), Trichostrongylus spp (98.2%), Oesophagostomum spp (100%), and Bunostomum phlebotomum (100%). Effects of treatment against adults of Nematodirus spp (100%) were not significant, whereas, degrees of infection of Strongyloides papillosus, Capillaria sp, and Trichuris sp were insufficient for evaluation. The activity of febantel was variable in controlling inhibited and late fourth-stage larvae of Cooperia spp (100% and 100%, respectively) and Ostertagia spp (-81.5% and 36.7%). Numbers of larval Nematodirus and Capillaria sp were insufficient for evaluation. Overall, febantel administered at 5.0 mg/kg reduced populations of adult and larval strongyles and other gastrointestinal nematodes in calves by 80.7% (P = 0.002). An unexpected finding during the trial was the recovery of Oesophagostomum venulosum from all control calves.
authors.affiliation: College of Veterinary Medicine, Oregon State University, Corvallis 97331.
authors.forename: E P
authors.initials: EP
authors.lastname: Hoberg
authors.forename: G L
authors.initials: GL
authors.lastname: Zimmerman
authors.forename: L G
authors.initials: LG
authors.lastname: Rickard
authors.forename: D J
authors.initials: DJ
authors.lastname: Schons
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology; D004341:Drug Evaluation / Q000662:veterinary; D005243:Feces / Q000469:parasitology; D006146:Guanidines / Q000627:therapeutic use*; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D009814:Oesophagostomiasis / Q000453:epidemiology / Q000662:veterinary; D009922:Oregon; D010270:Parasite Egg Count / Q000662:veterinary
chemical_list: D006146:Guanidines; C017309:febantel