Nucleolar organizer regions in melanocytic dysplasia and melanoma.
Using silver (Ag) staining to demonstrate nucleolar organizer region-associated proteins (AgNORs), pigmented naevi exhibiting features of melanocytic dysplasia have been examined and compared with benign intradermal and compound naevi and with malignant melanomas. A highly significant difference was found between the numbers of AgNORs demonstrated in benign naevus cells and atypical melanocytes and in malignant melanocytes, suggesting that this technique may have a role in differentiating between difficult melanocytic lesions.
Fallowfield
M E
ME
Department of Histopathology, St George's Hospital, London, UK.
Dodson
A R
AR
Cook
M G
MG
D006801:Humans; D007150:Immunohistochemistry; D008544:Melanocytes / Q000473:pathology* / Q000648:ultrastructure; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure; D009697:Nucleolus Organizer Region / Q000648:ultrastructure*; D012834:Silver
D012834:Silver