Hydatidiform mole and HLA. III. HLA-antigen expression related to genomic origin.
In 52 conceptuses with known genomic origin, HLA determination was performed on whole villi and/or stromal cell cultures. In 26 androgenetic, diploid conceptuses, one or two paternal HLA-A,B haplotypes were found; twenty-four triploid conceptuses with two paternal and one maternal chromosome sets showed either one maternal and one paternal haplotype or one/two paternal HLA-A,B haplotypes. Consequently, androgenesis could not be demonstrated by lack of maternal antigens alone. Concomitant expression of three HLA haplotypes was not seen. HLA-A2 was passed on to the conceptus, both in the genetic subgroups and in the entire series, more frequently than expected.
Hansen
H E
HE
Institute of Forensic Genetics, Copenhagen, Denmark.
Vejerslev
L O
LO
Larsen
S O
SO
D005260:Female; D005333:Fetus / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics* / Q000276:immunology; D008297:Male; D011003:Ploidies; D011247:Pregnancy
D006680:HLA Antigens