[Mechanisms of disturbance of the secretion of prolactin in patients with acromegaly].
Metoclopramide (DA-antagonist, M) tests were performed in 21 patients with acromegaly and in controls; the levels of adrenohypophyseal hormones were determined before and after drug administration. Irrespective of the basal level of prolactin (P) all the patients demonstrated a decrease in stimulated P secretion which was more noticeable in patients with hyperprolactinemia. The hyperergic response of TSH to M administration was observed in some of the patients with acromegaly. Such a response indicated an elevated tone of the dopaminergic (DA) system. The results obtained were suggestive of dysfunction of DA regulation of P secretion in all the patients with acromegaly.
Avakian
M R
MR
Marova
E I
EI
Dobracheva
A D
AD
Pankova
S S
SS
Bobrovskaia
T A
TA
D000172:Acromegaly / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006728:Hormones / Q000378:metabolism; D006801:Humans; D006966:Hyperprolactinemia / Q000209:etiology; D008297:Male; D008787:Metoclopramide; D011388:Prolactin / Q000378:metabolism*
D006728:Hormones; D011388:Prolactin; D008787:Metoclopramide
Mekhanizmy narusheniia sekretsii prolaktina u bol'nykh akromegalieĭ.