title: Development of the second generation Japanese encephalitis (JE) vaccine.
abstract: Recent analysis of Japanese encephalitis (JE) virus genome RNA, especially its nucleotide sequence, revealed the localization of virion envelope glycoprotein (E) gene on the virus genome. Since the E protein is the major protective antigen related with the virus neutralization, attempts have been made to produce the second generation JE vaccine by expressing the E protein using recombinant DNA technologies. These studies will eventually lead to control JE by mass-vaccination in several Asian countries where JE is one of the major public health problems.
authors.affiliation: Department of Virology, Nagasaki University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Igarashi
mesh_terms: D000330:Aedes / Q000166:cytology; D000818:Animals; D002478:Cells, Cultured; D004270:DNA, Circular / Q000096:biosynthesis; D004591:Electrophoresis, Polyacrylamide Gel; D004664:Encephalitis Virus, Japanese / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D014759:Viral Envelope Proteins / Q000235:genetics / Q000302:isolation & purification; D014765:Viral Vaccines / Q000302:isolation & purification*
chemical_list: D004270:DNA, Circular; D014759:Viral Envelope Proteins; D014765:Viral Vaccines