Familial Alzheimer's disease (FAD): co-segregation between alleles at the D21S11 DNA marker and the FAD gene in a particular pedigree.
Segregation studies of Alzheimer's disease (AD) gene and a cloned DNA probe (D21S11), which detects an EcoRI restriction fragment length polymorphism for a sequence located in the medial part of the long arm of chromosome 21, are reported in a large pedigree, in which AD is transmitted as an autosomal dominant mendelian trait. In this pedigree, the AD gene co-segregation with one of the alternative alleles at the probe raises the possibility of using such a marker for presymptomatic diagnosis of individuals at risk for the disease.
David
F
F
Laboratory of Melocular Genetics, INTS, Paris, France.
Clerget
F
F
Lucote
G
G
D000544:Alzheimer Disease / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21 / Q000032:analysis*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D010375:Pedigree; D010957:Plasmids
D005819:Genetic Markers