title: Intramedullary osteosclerosis. A report of the clinicopathologic features of five cases.
abstract: The clinicopathologic features of five patients with intramedullary osteosclerosis are presented. The patients, ranging in age from 8 to 52 years (mean 31 years), all presented with pain referred to the lower extremity. The sclerotic lesions involved the entire lower extremity in 1 patient, mid-tibial shaft in 2, distal tibia in 1, and distal fibula in 1 patient. The histopathologic features of intramedullary osteosclerosis overlap with those of melorheostosis. The differential diagnosis also includes a spectrum of entities, each characterized by osteosclerosis and each of which is compared and contrasted to the cases presented.
authors.affiliation: Department of Pathology, University Hospitals of Cleveland, OH 44106.
authors.forename: F W
authors.initials: FW
authors.lastname: Abdul-Karim
authors.forename: J R
authors.initials: JR
authors.lastname: Carter
authors.forename: J T
authors.initials: JT
authors.lastname: Makley
authors.forename: S C
authors.initials: SC
authors.lastname: Morrison
authors.forename: S D
authors.initials: SD
authors.lastname: Helper
authors.forename: M J
authors.initials: MJ
authors.lastname: Joyce
authors.forename: T F
authors.initials: TF
authors.lastname: Linke
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005360:Fibula / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008557:Melorheostosis / Q000175:diagnosis / Q000473:pathology; D008875:Middle Aged; D010026:Osteosclerosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology