[Modifying effect of ascorbic acid and sodium ascorbate on uterine carcomogenesis induced by 1,2-dimethylhydrazine in CBA mice].
Administration of ascorbic acid (0.3% in drinking water) inhibited the promoting effect of estradiol dipropionate on the 1,2-dimethylhydrazine-induced uterine sarcomogenesis in CBA mice. However administration of sodium ascorbate intensified the promoting effect of estradiol on the uterine sarcomogenesis, as evidenced by the shortening of the periods of tumour incidence.
Trukhanova
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D019813:1,2-Dimethylhydrazine; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology* / Q000633:toxicity*; D003043:Cocarcinogenesis; D004127:Dimethylhydrazines; D004357:Drug Synergism; D005260:Female; D008763:Methylhydrazines; D051379:Mice; D008808:Mice, Inbred CBA; D012513:Sarcoma, Experimental / Q000139:chemically induced*; D014594:Uterine Neoplasms / Q000139:chemically induced* / Q000517:prevention & control
D004127:Dimethylhydrazines; D008763:Methylhydrazines; D019813:1,2-Dimethylhydrazine; D001205:Ascorbic Acid
Modifitsiruiushchee vliianie askorbinovoĭ kisloty i askorbata natriia na sarkomogenez matki u mysheĭ linii CBA, indutsirovannyĭ 1,2-dimetilgidrazinom.