title: Bronchoalveolar lavage in chronic eosinophilic pneumonia. Analysis of six cases in comparison with other interstitial lung diseases.
abstract: We describe 6 patients with chronic eosinophilic pneumonia (CEP) investigated clinically and by bronchoalveolar lavage (BAL). The BAL findings of these 6 patients were compared with those of 293 patients with other interstitial lung diseases (ILD): 184 with sarcoidosis, 63 with hypersensitivity pneumonitis, 46 with idiopathic pulmonary fibrosis (IPF). In patients with CEP, BAL analysis was characterized by a markedly increased number of eosinophils (mean +/- 1 SD: 54.2 +/- 26.4 of effector cells; in control subjects, eosinophils were less than 1% of effector cells). In patients with other ILD, BAL fluid analysis showed a significant increase in the percentage of eosinophils only in the group of IPF, but in IPF the increased number of eosinophils is linked with a significant increase in the percentage of neutrophils. These findings indicate that besides the classic patterns of lymphocytosis or polymorphonuclear leukocytosis, a predominantly eosinophilic pattern may also be present in the BAL fluid. Moreover, BAL may contribute to understanding the pathogenesis of lung tissue damage in CEP.
authors.affiliation: Istituto di Clinica delle Malattie dell'Apparato Respiratorio, Università degli Studi di Parma, Italia.
authors.forename: A
authors.initials: A
authors.lastname: Pesci
authors.forename: G
authors.initials: G
authors.lastname: Bertorelli
authors.forename: P
authors.initials: P
authors.lastname: Manganelli
authors.forename: P A
authors.initials: PA
authors.lastname: Mori
authors.forename: F
authors.initials: F
authors.lastname: Strinati
authors.forename: E
authors.initials: E
authors.lastname: Marangio
authors.forename: D
authors.initials: D
authors.lastname: Olivieri
mesh_terms: D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D002452:Cell Count; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011657:Pulmonary Eosinophilia / Q000175:diagnosis* / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000473:pathology; D012507:Sarcoidosis / Q000473:pathology