title: [Combined treatment of chronic prostatitis with sulfamethoxazole-trimethoprim and hachimi-ji-oh-gan].
abstract: Treatment of chronic prostatitis is difficult and many antimicrobial drugs have been tried. Although these drugs showed good permeability into prostatic fluid in experimental studies, they have limited value in clinical use and development of more effective drugs has been anticipated. A study was performed on the effect of Hachimi-ji-ji-oh-gan, a traditional Chinese medicine, for the treatment of chronic prostatitis. Symptoms were improved in 53% of the patients treated with sulfamethoxazole-trimethoprim alone for two weeks and in 84% of those treated with Hachimi-ji-oh-gan in addition to sulfamethoxazole-trimethoprim for two weeks. Since Hachimi-ji-oh-gan has no antimicrobial effect, the drug may change the characteristics of the prostatic tissue or prostatic fluid providing a favorable condition for antimicrobial agents to penetrate into the prostatic fluid. Further examination is necessary to disclose the machanism of Hachimi-ji-oh-gan on the effect of prostatitis.
authors.affiliation: Department of Urology, Kinki University School of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Kaneko
authors.forename: T
authors.initials: T
authors.lastname: Akiyama
authors.forename: T
authors.initials: T
authors.lastname: Kurita
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011472:Prostatitis / Q000188:drug therapy*; D013420:Sulfamethoxazole / Q000008:administration & dosage* / Q000627:therapeutic use; D014295:Trimethoprim / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D004365:Drugs, Chinese Herbal; C054591:hachimijiogan; D014295:Trimethoprim; D013420:Sulfamethoxazole