Nimodipine treatment of subarachnoid hemorrhage.
In a pilot study of 6 patients with subarachnoid hemorrhage caused by a ruptured intracranial (grade IV (Hunt and Hess) aneurysm the hemodynamics and plasma-nimodipine concentrations have been observed during a 3-week period of treatment. We found that 3 patients developed reversible hypotension during the nimodipine treatment and that the hypotension tendency could be related to the plasma-nimodipine level and not to a more or less severe sensitivity to nimodipine. Repeated measurements of blood pressure, plasma-nimodipine and regional cerebral blood flow (rCBF) are necessary for the purpose of obtaining the optimum treatment and for evaluating the effect of treatment.
Laursen
J
J
Department of Neurosurgery, University Hospital of Arhus, Denmark.
Jensen
F
F
Mikkelsen
E
E
Jakobsen
P
P
D000328:Adult; D001794:Blood Pressure; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009553:Nimodipine / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D010865:Pilot Projects; D013345:Subarachnoid Hemorrhage / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology
D009553:Nimodipine