title: Beta-adrenoceptor blockade does not modify gastrointestinal transit time in healthy volunteers.
abstract: The effect of non-selective beta-adrenoceptor blockade on gastrointestinal transit time (GITT) was measured in 20 healthy volunteers with a radiographic method. By means of double-blind, crossover technique, each subject was studied during treatment with 80 mg oral propranolol or placebo twice daily for 7 days. The number of radiopaque markers retained in the alimentary tract did not differ significantly between the placebo and the propranolol periods. The mean GITT for placebo was 78 h and for propranolol 77 h. During propranolol treatment the heart rate and blood pressure were significantly decreased. It is concluded that non-selective beta-adrenoceptor blockade does not influence human gastrointestinal transit time under unstrained conditions.
authors.affiliation: Dept. of Surgery, Norra Alvsborgs Länslasarett, Trollhättan, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Hallerbäck
authors.forename: H
authors.initials: H
authors.lastname: Glise
authors.forename: F
authors.initials: F
authors.lastname: Karlsson
authors.forename: M
authors.initials: M
authors.lastname: Tegnebjer
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D008297:Male; D011433:Propranolol / Q000009:adverse effects / Q000494:pharmacology*; D011897:Random Allocation
chemical_list: D011433:Propranolol