Effect of bupivacaine hydrochloride on bilirubin production in neonatal rats.
The rate of bilirubin production was studied in 12-hour-old rats exposed to bupivacaine HCl by subcutaneous injection. The bilirubin production was estimated by measuring the excretion rate of carbon monoxide (VeCO) using an open flow-through system. No significant difference was found between the VeCO of bupivacaine HCl-treated and control animals, or between the levels of bilirubin in the pooled blood of treated (0.92 +/- 0.32 SE mg/dl) and control (1.0 +/- 0.28 SE mg/dl) animals. These negative findings support the clinical studies which have not demonstrated an association between epidural anesthesia with bupivacaine HCl and neonatal jaundice.
Gale
R
R
Department of Pediatrics, Stanford University School of Medicine, Calif.
Vreman
H J
HJ
Ferguson
J E
JE
Stevenson
D K
DK
D000818:Animals; D000831:Animals, Newborn; D001663:Bilirubin / Q000096:biosynthesis*; D002045:Bupivacaine / Q000494:pharmacology*; D002248:Carbon Monoxide / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D002248:Carbon Monoxide; D001663:Bilirubin; D002045:Bupivacaine