Regional changes in brain histamine levels following dietary-induced thiamine deficiency in rats.
Histamine levels in thiamine deficient rats were significantly lower in the hippocampus, amygdala, olfactory bulb, thalamus and pons-medulla oblongata than those of normal and pair-fed groups. In the case of the hypothalamus, thiamine deficiency produced a significant increase in histamine levels. These changes observed in the thiamine deficient group were reversed to the normal levels by supplying the normal diet. These data present a new finding that thiamine deficiency affects the central histaminergic neuron system as well as other monoaminergic systems.
Onodera
K
K
Department of Pharmacology, Tohoku University School of Dentistry, Senda, Japan.
Maeyama
K
K
Watanabe
T
T
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004032:Diet; D006632:Histamine / Q000378:metabolism*; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013832:Thiamine Deficiency / Q000378:metabolism*
D006632:Histamine