Relative concentration of astatine-211 and iodine-125 by human fetal thyroid and carcinoma of the thyroid in nude mice.
The concentrations of 211At and 125I were measured in various tissues in nude mice bearing xenografts of human thyroid tissue (fetal and malignant). The relative concentration of the two halogens was obtained at 4 and 24 h after injection. Samples were taken of the host blood, muscle and thyroid gland and the grafted tissues. The mouse thyroid concentrated 125I more efficiently than 211At but the human grafts concentrated both halogens about equally.
Cobb
L M
LM
Division of Experimental Pathology and Therapeutics, Medical Research Council Radiobiology Unit, Harwell, Didcot, Oxon, U.K.
Harrison
A
A
Dudley
N E
NE
Carr
T E
TE
Humphreys
J A
JA
D000230:Adenocarcinoma / Q000032:analysis; D000818:Animals; D001246:Astatine / Q000008:administration & dosage / Q000032:analysis*; D001345:Autoradiography; D002277:Carcinoma / Q000032:analysis; D005333:Fetus; D006801:Humans; D007274:Injections, Intraperitoneal; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000032:analysis*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D013961:Thyroid Gland / Q000032:analysis* / Q000637:transplantation; D013964:Thyroid Neoplasms / Q000032:analysis*
D007457:Iodine Radioisotopes; D001246:Astatine