title: Doppler echocardiographic assessment of left ventricular diastolic function in patients with primary lung cancer treated with doxorubicin.
abstract: Eighteen patients were examined by Doppler echocardiography before and after treatment with doxorubicin (DXR). Early left ventricular filling rate decreased from 66 +/- 15 to 51 +/- 10 cm/sec whereas late filling rate increased from 48 +/- 12 to 61 +/- 9 cm/sec (p less than 0.05) with inversion of the E/A ratio suggesting an impairment of left ventricular diastolic function; conversely no significant changes were found in systolic function indexes. These results suggest that follow-up of patients treated with DXR must include left ventricular diastolic function studies. Doppler echocardiography can be successfully used to detect the presence of diastolic abnormalities.
authors.affiliation: Clinica Medica, II Facoltà di Medicina, Napoli, Italia.
authors.forename: S
authors.initials: S
authors.lastname: Maione
authors.forename: A
authors.initials: A
authors.lastname: Giunta
authors.forename: B
authors.initials: B
authors.lastname: Tuccillo
authors.forename: R
authors.initials: R
authors.lastname: Biagini
authors.forename: P
authors.initials: P
authors.lastname: Del Rosso
authors.forename: A
authors.initials: A
authors.lastname: Pezza
authors.forename: F
authors.initials: F
authors.lastname: De Blasio
mesh_terms: D000328:Adult; D000368:Aged; D003971:Diastole / Q000187:drug effects*; D004317:Doxorubicin / Q000009:adverse effects*; D004452:Echocardiography; D005260:Female; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D013599:Systole / Q000187:drug effects
chemical_list: D004317:Doxorubicin