title: The fetal intrahepatic umbilical vein as an alternative to cord needling for prenatal diagnosis and therapy.
abstract: Seventy-one fetal blood samplings (FBS) were attempted from the intrahepatic portion of the umbilical vein (IHV) at 18-34 weeks; 54 were attempted primarily and 17 secondarily after a failed attempt at the placental cord insertion. Fetal blood was obtained in 89 per cent of the cases. Intravascular transfusion (IVT) was attempted on 31 occasions and successful in 24 (77 per cent). In all cases of failed sampling or transfusion via the IHV, prenatal diagnosis and/or therapy was accomplished using alternative procedures. On only one occasion was the procedure postponed. There were no losses or neonatal morbidity attributable to the procedure. FBS from the IHV may be considered as an alternative approach to sampling the placental cord insertion. It is recommended in cases where the approach to the placental cord insertion is difficult or hazardous.
authors.affiliation: Royal Postgraduate Medical School, Queen Charlotte's Maternity Hospital, London, U.K.
authors.forename: U
authors.initials: U
authors.lastname: Nicolini
authors.forename: J
authors.initials: J
authors.lastname: Santolaya
authors.forename: O E
authors.initials: OE
authors.lastname: Ojo
authors.forename: N M
authors.initials: NM
authors.lastname: Fisk
authors.forename: C
authors.initials: C
authors.lastname: Hubinont
authors.forename: M
authors.initials: M
authors.lastname: Tonge
authors.forename: C H
authors.initials: CH
authors.lastname: Rodeck
mesh_terms: D001800:Blood Specimen Collection / Q000379:methods; D001805:Blood Transfusion, Intrauterine; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014470:Umbilical Cord; D014471:Umbilical Veins