Inhibitory effects of 9-(2,3-dihydroxypropyl)adenine and 3-(adenin-9-yl)-2-hydroxypropanoic acid 2-methylpropylester on potato virus X replication.
9-(2,3-Dihydroxypropyl)adenine (DHPA) and 3-(adenin-9-yl)-2-hydroxypropanoic acid 2-methylpropylester (AHPA-MP)) markedly inhibit the replication of potato virus X (PVX). The latter compound inhibits virus replication more effectively at the lower concentration range. In synchronized virus-infected leaf-disks, the time-response course of inhibition by both compounds is almost identical, and similar to that of cycloheximide.
Schuster
G
G
Department of Life Sciences, Karl-Marx-University, Leipzig, G.D.R.
Holý
A
A
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000998:Antiviral Agents; D010942:Plant Viruses / Q000187:drug effects* / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; C016391:9-(2,3-dihydroxypropyl)adenine; C048336:3-adenin-9-yl-2-hydroxypropanoic acid isobutyl ester; D000225:Adenine