[Ways to prevent the calcification of heart valve bioprostheses].
The influence of the method of preservation and application of medicinal preparation xydiphone on the process of calcification of xenograft bioprostheses in a classic model of subcutaneous implantation of bioprosthesis cusps in rats has been studied. It is estimated that fermentative processing does not influence the intensity of calcification, while the immobilization of heparin to tissue decreases the amount of calcium in implants 4.5 times. Combination of heparin immobilization with peroral administration of xydiphone results in summing up of the effects, decreasing the amount of calcium in experimental set of cusps up to the level of nonimplanted ones.
Barbarash
L S
LS
Zhuravleva
I Iu
IIu
Medvedeva
V M
VM
Shaposhnikov
A N
AN
D000818:Animals; D001021:Aortic Valve; D001705:Bioprosthesis / Q000009:adverse effects*; D002114:Calcinosis / Q000517:prevention & control*; D004164:Diphosphonates / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D012968:Etidronic Acid; D005260:Female; D006349:Heart Valve Diseases / Q000517:prevention & control*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006493:Heparin / Q000627:therapeutic use; D011475:Prosthesis Failure; D051381:Rats; D014021:Tissue Preservation / Q000379:methods
D004164:Diphosphonates; D006493:Heparin; D012968:Etidronic Acid
Puti profilaktiki kal'tsifikatsii bioprotezov klapanov serdtsa.