Pure pancreatic juice in humans: orange-lemon-juice-induced secretory effects. Comparative analysis with a regular meal, sorbitol, acidified peptone broth and secretin.
The secretory effect elicited by the ingestion of 100 ml of orange-lemon juice (O.-L.J.) was studied on pure pancreatic juice obtained from a catheter placed in the human Wirsung duct at surgery. These changes were compared with those evoked by a regular meal (R.M.), the ingestion of a Sorbitol solution (S.S.), the intragastric infusion of an acidified peptone broth (A.P.B.) and an i.v. single injection of secretin (Boots, 1.0 U/kg). The O.-L.J. induced purer pancreatic secretion response (flow, bicarbonate and enzyme output) than that triggered by the R.M., S.S. and A.P.B. The O.-L.J. evoked peak values, were observed earlier (60 min) than with a R.M. (90 min) ingestion. The 120-min-cumulative values confirmed these findings and disclosed that O.-L.J. elicits a rate of secretion and bicarbonate output closely similar to that of an i.v. secretin injection and amylase response greater than that evoked by this hormone. Thus, O.-L.J. ingestion proved to be an unexpected powerful stimulus of exocrine pancreatic secretion.
Tiscornia
O M
OM
Gastroenerologic Unit, Hospital de Clinicas (Universidad de Buenos Aires), Argentina.
Cresta
M A
MA
Celener
D
D
Negri
G
G
Vaccaro
M I
MI
Waisman
H
H
Bustos Fernandez
L
L
Dreiling
D A
DA
D000328:Adult; D000368:Aged; D002957:Citrus; D004435:Eating; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010189:Pancreatic Juice / Q000187:drug effects / Q000378:metabolism*; D010461:Peptones / Q000494:pharmacology*; D012633:Secretin / Q000494:pharmacology*; D013012:Sorbitol / Q000494:pharmacology*
D010461:Peptones; D012633:Secretin; D013012:Sorbitol