Structural analysis of 21-hydroxypregn-4-ene-3,20-dione (deoxycorticosterone) derivative compounds. Part II: Proton NMR spectra.
Complete analysis of the proton nuclear magnetic resonance spectrum of desoxycorticosterone (DOC) has been made using selective double irradiation, two-dimensional experiments, relaxation rate, and nuclear Overhauser effect measurements in order to specify the structure and conformation of products encountered during the preparation of the specific antigen DOC-bovine serum albumin (BSA). It has been shown that DOC has the normal P conformation with ring A half-chair, and ring B chair. This confirms results previously obtained by circular dichroism measurements.
Kouadio
L
L
Laboratoire de Chimie Analytique II, Hopital de l'Antiquaille, Universite Claude Bernard Lyon, France.
Bernard
P
P
Sabot
J F
JF
Petit-Ramel
M M
MM
Barbier
C M
CM
Pinatel
H J
HJ
D003900:Desoxycorticosterone / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation
D003900:Desoxycorticosterone