title: [Mechanisms of disturbance of the secretion of prolactin in patients with acromegaly].
abstract: Metoclopramide (DA-antagonist, M) tests were performed in 21 patients with acromegaly and in controls; the levels of adrenohypophyseal hormones were determined before and after drug administration. Irrespective of the basal level of prolactin (P) all the patients demonstrated a decrease in stimulated P secretion which was more noticeable in patients with hyperprolactinemia. The hyperergic response of TSH to M administration was observed in some of the patients with acromegaly. Such a response indicated an elevated tone of the dopaminergic (DA) system. The results obtained were suggestive of dysfunction of DA regulation of P secretion in all the patients with acromegaly.
authors.forename: M R
authors.initials: MR
authors.lastname: Avakian
authors.forename: E I
authors.initials: EI
authors.lastname: Marova
authors.forename: A D
authors.initials: AD
authors.lastname: Dobracheva
authors.forename: S S
authors.initials: SS
authors.lastname: Pankova
authors.forename: T A
authors.initials: TA
authors.lastname: Bobrovskaia
mesh_terms: D000172:Acromegaly / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006728:Hormones / Q000378:metabolism; D006801:Humans; D006966:Hyperprolactinemia / Q000209:etiology; D008297:Male; D008787:Metoclopramide; D011388:Prolactin / Q000378:metabolism*
chemical_list: D006728:Hormones; D011388:Prolactin; D008787:Metoclopramide
vernacular_title: Mekhanizmy narusheniia sekretsii prolaktina u bol'nykh akromegalieĭ.