title: [Problems of pathogenesis of ovarian and idiopathic hirsutism].
abstract: The content of total testosterone (T), dehydrotestosterone (DHT), androstenedione (A), estradiol (E2), luteotropin (LH) and follicle-stimulating hormone (FSH) was studied in patients with ovarian and idiopathic hirsutism by a radioimmunoassay. The level of T-E-binding globulin (TEBG) was determined by 3H-DHT binding. Concentrations of free and TEBG-unbound T, DHT and E2 were calculated on the basis of the mass action law. The level of free and TEBG-unbound T and DHT was found to be the most reliable marker of the excessive production of androgens in hirsutism. The level of total T and DHT was raised in 50-60% of patients with hirsutism. Patients with hirsutism of ovarian genesis were characterized by considerable blood elevation of LH and FSH with still greater values in patients with menstrual disturbance, and by a rise of an A level. Difference found in hormonal indices can be used in differential diagnosis of ovarian and idiopathic hirsutism.
authors.forename: L V
authors.initials: LV
authors.lastname: Tarasenko
authors.forename: A G
authors.initials: AG
authors.lastname: Reznikov
authors.forename: E A
authors.initials: EA
authors.lastname: Benikova
authors.forename: S V
authors.initials: SV
authors.lastname: Varga
authors.forename: D I
authors.initials: DI
authors.lastname: Derevianko
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006628:Hirsutism / Q000097:blood / Q000209:etiology*; D006728:Hormones / Q000097:blood; D006801:Humans; D010049:Ovarian Diseases / Q000150:complications*
chemical_list: D006728:Hormones
vernacular_title: Voprosy patogeneza ovarial'nogo i idiopaticheskogo girsutizma.