Imaging and kinetics studies with radiolabelled autologous low-density lipoproteins (LDL) in human atherosclerosis.
Experimental data in rabbits show a significantly (P less than 0.01) increased vascular uptake of autologous 125I-radiolabelled low-density lipoproteins (LDL) at various time intervals after experimental lesioning. In some vascular areas in patients, a positive gamma-camera image can be obtained as early as 30 min after reinjection of autologous 123I-labelled LDL only. Monitoring of kinetics provides reliable information on localized increased LDL entry in certain vascular areas. Although a number of methodological improvements are needed, the technique described may be of clinical value in the future.
Sinzinger
H
H
Atherosclerosis Research Group (ASF), Vienna, Austria.
Angelberger
P
P
D000328:Adult; D000368:Aged; D000818:Animals; D001161:Arteriosclerosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008077:Lipoproteins, LDL / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D011817:Rabbits; D011877:Radionuclide Imaging
D007457:Iodine Radioisotopes; D008077:Lipoproteins, LDL