The ability by different preparations of porcine parvovirus to enhance humoral immunity in swine and guinea pigs.
The capacity of different preparations of inactivated porcine parvovirus to stimulate antibody response was studied. The adjuvants chosen were aluminium hydroxide gel [Al(OH)3, 30-50%], water-in-mineral-oil emulsion (w/Mo, 50%) alone or combined with Al(OH)3, and two synthetic products known as dimethyldioctadecylammoniumbromide (DDA, 0.16%) and an acrylic acid polymer resin (Carbopol 934P, 0.02%) respectively. For each preparation, swine and guinea pigs devoid of antibody to porcine parvovirus were inoculated. Among all the preparations tested, two of them i.e. emulsified Al(OH)3 adsorbed antigen and Carbopol 934P emulsified virus, gave the most significant antibody response in animals, without any difference being noted in the behaviour of the two animal species.
Gualandi
G L
GL
Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia, Brescia, Italy.
Losio
N M
NM
Muratori
G
G
Foni
E
E
D000276:Adjuvants, Immunologic; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000956:Antigens, Viral / Q000276:immunology; D002460:Cell Line; D005260:Female; D006168:Guinea Pigs; D006385:Hemagglutination Inhibition Tests; D010321:Parvoviridae / Q000276:immunology*; D013552:Swine; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D000956:Antigens, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines