title: [Analysis of the correlation between hydrophilic-lipophilic balance, coefficient of diffusion and hydrogen ion concentration in a series of nonsteroidal anti-inflammatory drugs].
abstract: A thorough investigation on the dependence of rate diffusion constants (Kd) of nonsteroidal antiinflammatory drugs on pH and pKa values was carried out. It is shown that a modified multiparametric curve-fitting technique may constitute an useful tool to describe the rate diffusion pH-profiles of ionogenic substances. A comparison between the Kd values and the corresponding distribution coefficients (log D) shows that these constants identify complementary parameters very useful in the study of structure-activity relationships of ionogenic substances.
authors.affiliation: Istituto di Chimica Farmaceutica, Tossicologica ed Applicata, Università di Cagliari.
authors.forename: M I
authors.initials: MI
authors.lastname: La Rotonda
authors.forename: B
authors.initials: B
authors.lastname: Cappello
authors.forename: M
authors.initials: M
authors.lastname: Grimaldi
authors.forename: C
authors.initials: C
authors.lastname: Silipo
authors.forename: A
authors.initials: A
authors.lastname: Vittoria
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004058:Diffusion; D006863:Hydrogen-Ion Concentration; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
vernacular_title: Analisi correlativa fra bilancio idrofilo-lipofilo, coefficiente di diffusion e concentrazione idrogenionica in una serie di farmaci antiinfiammatori non steroidei.