A familial risk of chronic renal failure among blacks on dialysis?
End-stage renal disease (ESRD) is strongly associated with both hypertension and diabetes. As both diabetes and hypertension tend to be familial, we hypothesized a familial clustering of ESRD cases. Using 114 cases from three dialysis centers and 99 controls, the exposure odds ratio was determined. Mantel-Haenszel analysis demonstrated that individual history of hypertension (ORmh = 5.14; 95% Cl = 2.29-11.56) and history of chronic renal failure in a first or second degree relative (chi 2mh = 5.12; p less than 0.05) were significant "risk" factors for being dialysed for ESRD, while family history of hypertension posed a more questionable risk (ORmh = 1.92 95% Cl 0.96-3.86). In fact, when the subset of patients identified with hypertensive renal disease was considered independently, the risk due to family history of hypertension increased 14-fold which suggests a role as a confounder for hypertensive renal disease. The effect of chronic renal failure in a relative was independent of family history of diabetes.
Ferguson
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R
Hypertension Center, Charles R. Drew Postgraduate Medical School, Los Angeles, CA 90059.
Grim
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CE
Opgenorth
T J
TJ
D044383:Black People; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D015141:Los Angeles; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012307:Risk Factors; D001741:Black or African American