title: Reduced prealbumin (transthyretin) in CSF of severely demented patients with Alzheimer's disease.
abstract: Prealbumin (transthyretin) quantified in CSF was negatively correlated with degree of dementia in 24 patients with dementia of Alzheimer type (DAT). There was neither a significant correlation between prealbumin in serum and degree of dementia nor between prealbumin in CSF and number of T lymphocytes in serum. There was no such relationship in 7 patients with multi-infarct dementia. Prealbumin was also quantified in 4 non-demented control groups, one consisting of 14 age- and sex-matched neurological patients, 17 with MS, 6 with ALS and 10 patients who had had a subarachnoid hemorrhage. Prealbumin was significantly lower in the last group. The study suggests that there may be a relationship between prealbumin levels in cerebrospinal fluid and degree of dementia. It is suggested that this may be caused by affection of the choroid plexus.
authors.affiliation: Department of Neurology, Haukeland Hospital, Bergen, Norway.
authors.forename: H
authors.initials: H
authors.lastname: Riisøen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000134:cerebrospinal fluid*; D003704:Dementia / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D008875:Middle Aged; D011228:Prealbumin / Q000097:blood / Q000134:cerebrospinal fluid*
chemical_list: D011228:Prealbumin