title: Studies on peroxidation of arachidonic acid in different liposomes below and above phase transition temperature.
abstract: The mechanism of Fe-induced peroxidation of arachidonic acid (AA) in small unilamellar vesicles (SUV) of dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine (DPPE) was studied below and above gel to liquid-crystalline phase transition temperature (Tm). In both liposomes the AA peroxidation resulted higher in the temperature range below Tm, but the extent of malonyldialdehyde (MDA) formation was dramatically lower in DPPE vesicles when compared with corresponding DPPC liposomes. A possible explanation for this is discussed.
authors.affiliation: Department of Medical Chemistry and Biochemistry, Faculty of Medicine, University of Milano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cervato
authors.forename: P
authors.initials: P
authors.lastname: Viani
authors.forename: M
authors.initials: M
authors.lastname: Masserini
authors.forename: C
authors.initials: C
authors.lastname: Di Iorio
authors.forename: B
authors.initials: B
authors.lastname: Cestaro
mesh_terms: D001095:Arachidonic Acids / Q000378:metabolism*; D002152:Calorimetry, Differential Scanning; D015227:Lipid Peroxidation; D008081:Liposomes / Q000378:metabolism*; D013050:Spectrometry, Fluorescence; D013696:Temperature
chemical_list: D001095:Arachidonic Acids; D008081:Liposomes