title: Paramedian reticular nucleus--sympathetic inhibition in spontaneously hypertensive rats.
abstract: The cardiovascular reactivity of various areas in the medulla related to sympathetic or parasympathetic activation, or to sympathetic inhibition, was compared in spontaneously hypertensive rats (SHR) and in normotensive rats Wistar-Kyoto (WKY) or Sprague-Dawley (SD). In SHR, which has an elevated resting systemic arterial blood pressure (SAP), the sympathetic pressor responses elicited from electrical stimulation of the dorsomedial medulla (DMM), parvocellular lateral nucleus (PVC) or ventrolateral medulla (VLM) were more profound than those in WKY and SD. The depressor and bradycardia responses elicited from electrical stimulation of the paramedian reticular nucleus (PRN) (which exerts both sympathetic and parasympathetic inhibitions) or from the area of the solitary nucleus/dorsomotor nucleus of vagus (NTS/DMV) (where stimulation leads to both parasympathetic activation and sympathetic inhibition) were also more intensive in SHR than in WKY and SD. The elicited pressor and depressor responses, however, were not significantly different between WKY and SD. Our results are consistent with previous findings (15) that in SHR an increased sympathetic activity of the pressor areas of medulla contributes to the pathogenesis of hypertension. Sympathetic inhibition (PRN and NTS/DMV areas) and parasympathetic activation (NTS/DMV area) from these areas, however, may not be critically involved.
authors.affiliation: Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan, Republic of China.
authors.forename: A M
authors.initials: AM
authors.lastname: Lin
authors.forename: H M
authors.initials: HM
authors.lastname: Lue
authors.forename: R H
authors.initials: RH
authors.lastname: Lin
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: C M
authors.initials: CM
authors.lastname: Pan
authors.forename: J S
authors.initials: JS
authors.lastname: Kuo
authors.forename: C Y
authors.initials: CY
authors.lastname: Chai
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002320:Cardiovascular Physiological Phenomena; D004558:Electric Stimulation; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D009433:Neural Inhibition; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*; D011921:Rats, Inbred WKY; D012146:Rest; D012154:Reticular Formation / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*