Intraventricular injection of antiserum to nerve growth factor delays the development of amygdaloid kindling.
To investigate the possibility that nerve growth factor (NGF) may play some role in the development of kindling, rabbit anti-NGF serum was injected into the third ventricle on the first 3 days of daily electrical stimulation of the basolateral amygdala. The number of stimulations required to reach full amygdaloid kindling increased significantly in the rat injected with anti-NGF serum compared to that in the rat injected with normal rabbit serum. It was confirmed that anti-NGF serum did not act as an anticonvulsant. The results demonstrate that NGF may be important for the long-lasting neuronal changes induced by daily electrical stimulation of the amygdala.
Funabashi
T
T
Department of Physiology, Yokohama City University School of Medicine, Japan.
Sasaki
H
H
Kimura
F
F
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D002552:Cerebral Ventricles / Q000502:physiology*; D004558:Electric Stimulation; D005260:Female; D007106:Immune Sera / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007696:Kindling, Neurologic; D009414:Nerve Growth Factors / Q000276:immunology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D007106:Immune Sera; D009414:Nerve Growth Factors