Ergometrine--a partial agonist at 5-HT receptors in the uterus isolated from the oestrogen-primed rat.
The mechanism of action of ergometrine has been studied in isolated uterus from the oestrogen-primed non-pregnant rat. Ergometrine (30 nM-1 microM) induced spasm and was antagonised selectively by methysergide and ICI 169,369, a proposed competitive antagonist at 5-hydroxytryptamine (5-HT2) receptors. The pA2 values of ICI 169,369 against 5-HT and ergometrine were not significantly different. Ergometrine (0.1-10 microM) was also a selective antagonist of 5-HT with no effect against acetylcholine or potassium chloride. It is suggested that ergometrine is a partial agonist involving 5-HT receptors in rat uterus.
Hollingsworth
M
M
Department of Physiological Sciences, Medical School, Manchester University, England.
Edwards
D
D
Miller
M
M
D000818:Animals; D004874:Ergonovine / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008784:Methysergide / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
D011804:Quinolines; D011985:Receptors, Serotonin; D004958:Estradiol; C054363:2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline; D004874:Ergonovine; D008784:Methysergide