title: Antitumor principles in mosses: the first isolation and identification of maytansinoids, including a novel 15-methoxyansamitocin P-3.
abstract: A novel 15-methoxyansamitocin P-3 [2], in company with three known maytansinoids 1, 3, and 4, was isolated for the first time from two Japanese mosses, Isothecium subdiversiforme and Thamnobryum sandei. All are potent cytotoxic compounds.
authors.affiliation: Sagami Chemical Research Center, Kanagawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sakai
authors.forename: T
authors.initials: T
authors.lastname: Ichikawa
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Yamashita
authors.forename: M
authors.initials: M
authors.lastname: Tanimoto
authors.forename: A
authors.initials: A
authors.lastname: Hikita
authors.forename: Y
authors.initials: Y
authors.lastname: Ijuin
authors.forename: K
authors.initials: K
authors.lastname: Kondo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008453:Maytansine / Q000031:analogs & derivatives / Q000302:isolation & purification* / Q000494:pharmacology; D010078:Oxazines / Q000302:isolation & purification*; D010944:Plants / Q000032:analysis
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010078:Oxazines; C057994:15-methoxyansamitocin P-3; D008453:Maytansine; C015682:ansamitocins