Insulin receptors and glucose homeostasis in type 2 diabetics influenced by acetyl-salicylic acid treatment.
The effect of acetyl-salicylic acid administration on insulin receptors on the erythrocytes and the changes of glucose homeostasis examined by hyperglycaemic clamps were evaluated in 8 Type 2 diabetics. Significantly increased number of insulin receptors and decreased insulin affinity constants were found in diabetics after the acetyl-salicylic acid treatment (p less than 0.02). Significantly decreased tissue sensitivity to insulin and metabolic clearance rate of insulin (p less than 0.02) were observed in Type 2 diabetics after the acetyl-salicylic acid treatment. We conclude that acetyl-salicylic acid may impair glucose homeostasis due to interference with insulin action in peripheral tissues.
Skrha
J
J
Department of Internal Medicine, Faculty of Medicine, Charles University, Prague/Czechoslovakia.
Hilgertová
J
J
Svacina
S
S
Srámková
J
J
Páv
J
J
D000368:Aged; D001241:Aspirin / Q000494:pharmacology* / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011972:Receptor, Insulin / Q000378:metabolism*
D011972:Receptor, Insulin; D005947:Glucose; D001241:Aspirin