D-penicillamine metabolism: in vitro studies of S-oxidation mechanisms.
The metabolism of D-penicillamine was studied in vitro using microsomal and cytosolic fractions of liver from DA-strain rats. Formation of inorganic sulphate, presumably via an S-oxidative pathway, was catalysed by both fractions. However, microsomal S-oxidation was higher in female animals than males, the sex differences being reversed with cytosolic fractions. The total yield of inorganic sulphate was similar for both sexes. Cytochrome P-450 isoenzymes did not appear to be directly involved.
Pilkington
A E
AE
Department of Biochemistry, University of Birmingham, England.
Waring
R H
RH
D000818:Animals; D002233:Carbocysteine / Q000378:metabolism; D003545:Cysteine / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003600:Cytosol / Q000201:enzymology; D005260:Female; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D010084:Oxidation-Reduction; D010396:Penicillamine / Q000378:metabolism*; D051381:Rats; D013431:Sulfates / Q000378:metabolism*
D013431:Sulfates; D002233:Carbocysteine; D003577:Cytochrome P-450 Enzyme System; D010396:Penicillamine; D003545:Cysteine