[The action of different food factors on the lipid peroxidation processes in the liver microsomes of rats].
Three series of experiments were conducted to study the effects of varying food factors on lipid peroxidation (LPO) activity in rat liver microsomes. The food rations contained heat-treated sunflower oil, soybean protein isolate, krill protein concentrate. A long-term intake of heat-treated oxidation products was attended by significant activation of LPO in the enzymatic system, by elevation of cytochrome P-450 level, by increased activity of ethylmorphine N-demethylase and aniline n-hydroxylation. The period of half-inactivation of cytochrome P-450 was significantly shortened in NADPH-dependent LPO. The rate of NADPH-dependent LPO was not significantly different in the animals given equal amounts of soybean protein isolate or casein (control). Activation of NADPH-dependent LPO and induction of cytochrome P-450 were recorded in liver microsomes of the animals given krill protein. The high concentration of cytochrome P-450 (in the homogenate and microsomes) correlated with the acceleration of hydroxylation of standard substrates ethylmorphine and aniline.
Feoktistova
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Martinchik
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Bondarev
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Zilova
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D000818:Animals; D003445:Crustacea; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000378:metabolism; D006900:Hydroxylation; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008862:Microsomes, Liver / Q000201:enzymology*; D010938:Plant Oils / Q000008:administration & dosage / Q000378:metabolism; D014674:Plant Proteins, Dietary / Q000008:administration & dosage / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D030262:Soybean Proteins; D013025:Glycine max; D000074242:Sunflower Oil
D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D004044:Dietary Proteins; D010938:Plant Oils; D014674:Plant Proteins, Dietary; D030262:Soybean Proteins; D000074242:Sunflower Oil; C058429:krill protein extract; D008315:Malondialdehyde
Vozdeĭstvie razlichnykh pishchevykh faktorov na protsessy perekisnogo okisleniia lipidov v mikrosomakh pecheni krys.