Effect of buthionine sulfoximine, an inhibitor of glutathione biosynthesis, on the selenium-induced lethality in mice.
The effect of buthionine sulfoximine (BSO), an inhibitor of glutathione (GSH) biosynthesis, on the selenium induced-lethality was examined in mice. A single injection of BSO (500 mg/kg, i.p.) markedly decreased the concentration of GSH in the liver after 5 hr. The acute lethality induced by selenium was greatly increased in BSO-treated mice. In contrast, the selenium induced-lethality decreased by pre- and post-treatments of cysteine (100 mg/kg, i.p.) in mice.
Ishikawa
M
M
Cancer Research Institute, Tohoku College of Pharmacy, Sendai, Japan.
Takayanagi
G
G
Sasaki
K
K
D000818:Animals; D019328:Buthionine Sulfoximine; D003545:Cysteine / Q000494:pharmacology; D004347:Drug Interactions; D005978:Glutathione / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D012643:Selenium / Q000633:toxicity*
D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D005978:Glutathione; D012643:Selenium; D003545:Cysteine