NSAID-induced mucosal injury.
Nonsalicylate, nonsteroidal anti-inflammatory drug (NSAID)-induced injury to the gastroduodenal mucosa may be responsible for significant ulceration and bleeding. The pathophysiology of gastroduodenal injury is reviewed and risk factors predisposing to NSAID injury are discussed. Finally, data are presented on the concurrent use of prostaglandin analogues and sucralfate in preventing mucosal injury.
Liebowitz
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Sequoia Hospital, Redwood City, California.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000187:drug effects; D005756:Gastritis / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D009780:Occult Blood; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D011459:Prostaglandins E, Synthetic / Q000627:therapeutic use; D011706:Pyloric Antrum / Q000473:pathology; D012307:Risk Factors; D013392:Sucralfate / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011459:Prostaglandins E, Synthetic; D013392:Sucralfate