Immunohistological studies on tonsils of recurrent tonsillitis and tonsils with focal infections.
In this study, two experiments were made to investigate the immunological pathogenesis of PPP, a skin disease of so-called focal infections. One was the immunohistological study on tonsils with PPP and recurrent tonsillitis. In the investigation, monoclonal antibodies against T lymphocytes and anti-immunoglobulin antibodies were used to reveal the distribution of T and B cell subsets on frozen sections of tonsils. But no difference between tonsils with focal infection and recurrent tonsillitis was observed in the distribution of T and B cell subsets. The other was the identification of a common antigen between tonsillar epithelium of PPP and hand-sole skin by use of one monoclonal antibody against PPP-tonsillar epithelium, which was made in our laboratory. Monoclonal antibody ATE-3 was in IgM, and recognized about 35 kilo dalton molecular weight protein of a tonsillar epithelium of PPP. This antibody reacted with the basal layer cells of the tonsillar epithelium and the suprabasilar cells of plantar skins of PPP. But ATE-3 did not react with normal tonsillar epithelium and normal plantar skin.
Kuki
K
K
Department of Otolaryngology, Wakayama Medical College, Japan.
Tabata
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D000328:Adult; D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D004848:Epithelium / Q000276:immunology; D005490:Focal Infection / Q000276:immunology* / Q000473:pathology; D005533:Foot Dermatoses / Q000276:immunology* / Q000473:pathology; D006229:Hand Dermatoses / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000145:classification / Q000276:immunology; D014066:Palatine Tonsil / Q000276:immunology* / Q000473:pathology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012008:Recurrence; D014069:Tonsillitis / Q000276:immunology* / Q000473:pathology
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D011947:Receptors, Antigen, B-Cell