Intracavernous injection of vasoactive drugs in the rabbit.
To investigate the erectile response and side effects of intracavernous injection of vasoactive agents, 7 groups of 5 rabbits each underwent injection of either isotonic saline or 1 of 6 drugs. Phentolamine most consistently produced full erection with few inflammatory reactions, while phenoxybenzamine produced erection but also severe inflammation and sclerosis of the corpus cavernosum. With prostaglandin E1, neither erection nor inflammation was observed.
Stackl
W
W
Department of Urology, University of Vienna, Veterinary School, Austria.
Loupal
G
G
Holzmann
A
A
D000818:Animals; D002426:Cavernous Sinus; D007267:Injections; D007741:Labetalol / Q000494:pharmacology; D008297:Male; D010208:Papaverine / Q000494:pharmacology; D010410:Penile Erection / Q000187:drug effects*; D010643:Phenoxybenzamine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D011817:Rabbits; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity
D010879:Piperazines; D011458:Prostaglandins E; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D010643:Phenoxybenzamine; C015568:urapidil; D010208:Papaverine; D007741:Labetalol; D010646:Phentolamine