[Effect of long-term hypokinesia on the androgenic system in rats].
Rats were immobilized in small cages for 1, 5, 10, 15, 20, 30, 45, 60 or 90 days. After exposure the weight of testes, seminal vesicles and prostate as well as the volume of cell nuclei of the reticular area of the adrenal cortex was measured. The weight of seminal vesicles and prostate diminished 1.5-2 times while that of testes decreased insignificantly. Cell nuclei of the reticular area of the adrenal cortex were enlarged during the first 5 days of hypokinesia, returning to the baseline thereafter. Cell nuclei became less than the baseline after 20 days of hypokinesia. These changes in the reticular area were associated with secretion of glucocorticoids rather than androgens.
Kirillov
O I
OI
Kurilenko
L A
LA
D000302:Adrenal Cortex / Q000378:metabolism / Q000648:ultrastructure*; D000728:Androgens / Q000378:metabolism; D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure*; D008297:Male; D009929:Organ Size; D011467:Prostate / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D012669:Seminal Vesicles / Q000473:pathology*; D013315:Stress, Psychological / Q000473:pathology* / Q000503:physiopathology; D013737:Testis / Q000378:metabolism / Q000473:pathology*; D013997:Time Factors
D000728:Androgens
Vliianie dlitel'noĭ gipokinezii na androgennuiu sistemu krys.