title: [Tert-aminoalkyl derivatives of quinoxalinones, aza- and diazaquinoxalinones with analgesic activity].
abstract: A series of tert-aminoalkyl-derivatives of quinoxalin-2-one, aza- and diazaquinoxalin-2-one bearing in position 3 a benzyl group was prepared in order to compare with analogous 3-methyl derivatives as regards analgesic activity. The substitution causes various effects. In compounds (I) and (VI-IX) is found the expected increase in analgesic activity but with contemporaneous rise in toxicity. The compounds (IV) and (V) are of interest due to the presence of a strong separation of DL50 from DE50.
authors.affiliation: Istituto di Tecnica Farmaceutica, Università di Sassari.
authors.forename: A
authors.initials: A
authors.lastname: Mulé
authors.forename: G
authors.initials: G
authors.lastname: Pirisino
authors.forename: P
authors.initials: P
authors.lastname: Manca
authors.forename: M
authors.initials: M
authors.lastname: Satta
authors.forename: A
authors.initials: A
authors.lastname: Peana
authors.forename: F
authors.initials: F
authors.lastname: Savelli
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D001372:Aza Compounds / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D010147:Pain Measurement; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000700:Analgesics; D001372:Aza Compounds; D011810:Quinoxalines
vernacular_title: Terz-amminoalchilderivati di chinossalinoni, aza e diazachinossalinoni ad attività analgesica.