Propolis allergy. (III). Sensitization studies with minor constituents.
87% of the propolis product "LB-1", originally reported to be 1,1-dimethyl-allyl caffeic acid ester, was shown by GC/MS analysis to consist of 3 isomeric pentenyl caffeates, 63% of which are 1,1-dimethylallyl caffeate. These pentenyl caffeates proved to be the major sensitizers of propolis and of poplar bud secretion in our previous study. In addition, 3 further minor allergens have now been investigated. Experimental sensitization indicates that phenylethyl caffeate is as strong a sensitizer as the major allergen "LB-1", while benzyl salicylate is a moderate sensitizer. Benzyl cinnamate plays only a subordinate role. At least 3 further esters of caffeic acid or cinnamic acid remain to be studied. Interestingly, relationships between propolis and balsam of Peru were found. 8 compounds are common to both materials. Thus "cross-reactions" or concomitant reactions in propolis-sensitive individuals to balsam of Peru are explainable.
Hausen
B M
BM
Department of Dermatology, University Hospital, Hamburg, West Germany.
Wollenweber
E
E
D000368:Aged; D055598:Chemical Phenomena; D002621:Chemistry; D003429:Cross Reactions; D003877:Dermatitis, Contact / Q000209:etiology* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D011429:Propolis / Q000009:adverse effects* / Q000032:analysis / Q000276:immunology / Q000627:therapeutic use; D012116:Resins, Plant / Q000009:adverse effects*
D012116:Resins, Plant; D011429:Propolis