Seminal tract inflammation and male infertility. Correlations between leukospermia and clinical history, prostatic cytology, conventional semen parameters, sperm viability and seminal plasma protein composition.
A retrospective clinical evaluation of various types of semen analyses from infertile couples attending our Infertility Clinic was undertaken with the scope of studying the possible correlation between seminal inflammation and infertility. The parameters considered were leukospermia (severe, slight, constant or non-constant), clinical history (anamnestic data possibly inferring inflammation), conventional semen parameters, sperm viability (as assessed by capillary tube in vitro penetration test) and seminal plasma proteins patterns (SDS-PAGE). History data such as dysuria, urinary infection, cystitis symptoms and hematospermia were found to be significantly more frequent in infertile men with than in those without leukospermia. Leukospermia in itself did not seem to affect the conventional semen parameters such as total sperm count, motility (at 45 and 180 min) and/or morphology. The seminal volume could represent an exception to this rule. Furthermore, leukospermia did significantly affect sperm viability as evaluated by the capillary tube penetration test. Leukospermia was also significantly coupled to alterations of the seminal plasma protein composition (increase of the albumin concentration, decrease of prostatic markers and other anomalies).
Colpi
G M
GM
Urology Department, Civil Hospital of Magenta, Milan, Italy.
Roveda
M L
ML
Tognetti
A
A
Balerna
M
M
D001769:Blood; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005832:Genital Diseases, Male / Q000150:complications*; D006801:Humans; D007248:Infertility, Male / Q000209:etiology*; D007249:Inflammation; D007958:Leukocyte Count; D008297:Male; D009920:Orchitis / Q000150:complications; D011467:Prostate / Q000473:pathology; D011472:Prostatitis / Q000150:complications; D011506:Proteins / Q000032:analysis; D012189:Retrospective Studies; D012661:Semen / Q000032:analysis / Q000166:cytology*; D013076:Sperm Count; D013081:Sperm Motility; D013084:Sperm-Ovum Interactions; D013094:Spermatozoa / Q000002:abnormalities / Q000473:pathology*; D014526:Urethritis / Q000150:complications; D014552:Urinary Tract Infections / Q000150:complications
D011506:Proteins