title: Hydatidiform mole and HLA. III. HLA-antigen expression related to genomic origin.
abstract: In 52 conceptuses with known genomic origin, HLA determination was performed on whole villi and/or stromal cell cultures. In 26 androgenetic, diploid conceptuses, one or two paternal HLA-A,B haplotypes were found; twenty-four triploid conceptuses with two paternal and one maternal chromosome sets showed either one maternal and one paternal haplotype or one/two paternal HLA-A,B haplotypes. Consequently, androgenesis could not be demonstrated by lack of maternal antigens alone. Concomitant expression of three HLA haplotypes was not seen. HLA-A2 was passed on to the conceptus, both in the genetic subgroups and in the entire series, more frequently than expected.
authors.affiliation: Institute of Forensic Genetics, Copenhagen, Denmark.
authors.forename: H E
authors.initials: HE
authors.lastname: Hansen
authors.forename: L O
authors.initials: LO
authors.lastname: Vejerslev
authors.forename: S O
authors.initials: SO
authors.lastname: Larsen
mesh_terms: D005260:Female; D005333:Fetus / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics* / Q000276:immunology; D008297:Male; D011003:Ploidies; D011247:Pregnancy
chemical_list: D006680:HLA Antigens