Antibacterial activity of selected tropones and tropolones.
The antibacterial activity of 33 substituted and unsubstituted seven-member ring tropones and tropolones was examined on 14 reference strains representing Gram-positive and Gram-negative bacteria. It was shown that the chemical character and position of the substituent plays a distinct role in the biological activity of investigated compounds. Depending on the substituent the antibacterial effect may be either increased or diminished. C-1 thio and C-2 nitro derivatives of tropone are significantly more active than tropone. The dibenzotropone derivatives display no antibacterial activity. Hydroxymethyl derivatives of tropolone are more active than tropolone, while hydroxy-, isopropyl-, methyl- as well as tropolone acetates are equipotent.
Saleh
N A
NA
Department of Microbiology, Polish Academy of Sciences, Wroclaw.
Zwiefak
A
A
Mordarski
M
M
Pulverer
G
G
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003508:Cycloheptanes / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D015394:Molecular Structure; D014334:Tropolone / Q000031:analogs & derivatives / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D003508:Cycloheptanes; D014334:Tropolone