Malignant transformation in benign cystic teratomas: dermoids of the ovary.
Twenty-four cases with a malignant change involving one of the elements of a benign ovarian dermoid cyst are reported. Squamous cell carcinoma was most frequent. Eighteen patients (75%) were over 50 years of age. The prognosis is rather good if the tumor has not extended beyond the capsule, 85% surviving without detectable disease after 4 months to 9 years. The prognosis is very poor if the tumor has extended beyond the capsule, over 80% dying within 2 years. Hysterectomy with bilateral salpingo-oophorectomy is the treatment of choice, certainly in older patients. Additional treatment with cytostatics or radiation seems to have little influence on the prognosis.
Chadha
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S
Department of Pathology, Erasmus University Rotterdam, The Netherlands.
Schaberg
A
A
D000328:Adult; D000367:Age Factors; D000368:Aged; D003884:Dermoid Cyst / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D011230:Precancerous Conditions / Q000473:pathology*; D011379:Prognosis