title: Lack of an association between carcinoma of the stomach and the major histocompatibility complex (HLA) in Cape Coloureds.
abstract: A possible genetic contribution to the high incidence of gastric carcinoma in the Cape Coloured population of the Western Cape region of South Africa was investigated. The HLA-A, B, C, DR and DQ antigens were determined with a microcytotoxicity assay, and their frequencies compared in 124 individuals with gastric carcinoma and 4,560 controls. No significant difference was found, thus supporting the view that a genetic component has a minor, if any, role in gastric carcinogenesis.
authors.affiliation: Provincial Laboratory for Tissue Immunology, Observatory, Cape Town, South Africa.
authors.forename: R W
authors.initials: RW
authors.lastname: Martell
authors.forename: P J
authors.initials: PJ
authors.lastname: van Eeden
authors.forename: M V
authors.initials: MV
authors.lastname: Madden
authors.forename: E D
authors.initials: ED
authors.lastname: du Toit
authors.forename: D M
authors.initials: DM
authors.lastname: Dent
mesh_terms: D044383:Black People / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex; D013019:South Africa; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology
chemical_list: D006680:HLA Antigens