title: [Problems in therapy of thoracic esophageal cancer in view of recurrence in the lymph nodes].
abstract: The forms of recurrence from the first onset were confirmed in 171 out of 776 patients with thoracic esophageal cancer excised at our Department from 1959 to 1987; 87 patients (50.9%) had recurrence in the lymph nodes. Postoperative radiation in order to prevent recurrence in the lymph nodes was useful for the prevention of recurrence in the cervical lymph nodes, but radiation myelopathy/radiation pneumonitis might be of therapeutic difficulty in patients with recurrence in the areas of radiation. Moreover, patients treated by irradiation were apt to be involved in visceral recurrence. Incidence of recurrence in the lymph nodes was less in patients who had dissection in three areas than that in patients who received dissection in one or two. However, recurrence was observed in the border region between the cervix and the thorax, on the left side of the trachea, in the anterior portion and on the left side of the hilum in the areas of dissection. Useful postoperative chemotherapy is desirable in consideration of the fact that recurrence in the lymph nodes was observed at the posterior region of the pharynx, at the temporal region and in the pelvis and that dissemination and visceral recurrence were increased.
authors.affiliation: Second Department of Surgery, Chiba University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Onoda
authors.forename: K
authors.initials: K
authors.lastname: Okuyama
authors.forename: N
authors.initials: N
authors.lastname: Tohnosu
authors.forename: Y
authors.initials: Y
authors.lastname: Ymamoto
authors.forename: H
authors.initials: H
authors.lastname: Matsubara
authors.forename: T
authors.initials: T
authors.lastname: Kozu
authors.forename: K
authors.initials: K
authors.lastname: Isono
mesh_terms: D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000601:surgery*; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000517:prevention & control*