Erythrocyte acid phosphatase polymorphism: relationship with birth weight, duration of gestation, and congenital abnormalities.
No statistically significant relationships were observed between the red blood cell acid phosphatase polymorphism (ACP-1) and birth weight, duration of gestation and proportion of preterm infants in a large series of newborn infants (greater than 8000) in Cardiff. These results are contrasted with those of a similar, but smaller, series studied by Bottini's group in Rome, where some apparently significant effects were detected. The Cardiff survey did show a significant relationship between ACP-1 genotypes and the presence or absence of congenital abnormalities, but since this was largely attributable to an excess of ACP-1 CA individuals with abnormalities, a category with a small expected value, further data are required to confirm the validity of this observation.
Ward
R D
RD
Department of Human Sciences, Loughborough University of Technology, Leicestershire, U.K.
D000135:Acid Phosphatase / Q000097:blood* / Q000235:genetics; D001724:Birth Weight; D000013:Congenital Abnormalities / Q000097:blood / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D005312:Fetal Blood / Q000201:enzymology; D005838:Genotype; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007234:Infant, Premature / Q000097:blood*; D011110:Polymorphism, Genetic
D000135:Acid Phosphatase