title: The effect of polyphloretin phosphate (PPP) on oral infiltration anaesthesia. An experimental investigation.
abstract: The possibilities to discontinue the anaesthetic effect using supplementary substances were studied. This investigation showed that administration of polyphloretin phosphate (PPP), 15 minutes after local anaesthetic injection, decreased the duration of infiltration anaesthesia of human teeth. The same result was also found when PPP was replaced by saline solution. However no effect on the duration of soft tissue anaesthesia was noted. There were no signs of adverse reactions.
authors.affiliation: Department of Oral Surgery, Karolinska Institute, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Nordenram
authors.forename: K
authors.initials: K
authors.lastname: Danielsson
mesh_terms: D000328:Adult; D000766:Anesthesia, Dental; D000772:Anesthesia, Local; D004311:Double-Blind Method; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage; D008046:Lip / Q000502:physiology; D010693:Phloretin / Q000031:analogs & derivatives; D011121:Polyphloretin Phosphate / Q000008:administration & dosage; D011897:Random Allocation; D012677:Sensation; D012965:Sodium Chloride / Q000008:administration & dosage; D013997:Time Factors; D014070:Tooth / Q000502:physiology
chemical_list: D012965:Sodium Chloride; D011121:Polyphloretin Phosphate; D008012:Lidocaine; D010693:Phloretin