Investigation into the effect of Fenoterol on mucociliary clearance in patients with chronic bronchitis.
We investigated the effect of Fenoterol, a selective beta 2 adrenoceptor stimulant, on mucociliary clearance in 12 patients with chronic bronchitis. Mucociliary clearance was measured with a scintillation camera after inhalation of a 99mTc labelled aerosol. Fenoterol was administered one h after acquisition commenced and imaging was maintained for a further two h. Three regions of interest (ROI) were selected over each lung to generate time activity curves. Corrections for decay, alveolar deposition (using 24 h image), cough and movement of activity through each ROI were carried out. An exponential function was fitted to the clearance curves to determine clearance rates. The increase in percentage clearance after Fenoterol administration for the left and right whole lung ROI was 35% and 36% per h respectively (P = 0.006 and 0.020). Fenoterol enhances cilial clearance in chronic bronchitis patients.
Weich
D J
DJ
Department of Internal Medicine, University of the Orange Free State, Bloemfontein, South Africa.
Viljoen
H
H
Sweetlove
M A
MA
Pretorius
P H
PH
van Rensburg
A J
AJ
Lötter
M G
MG
Minnaar
P C
PC
Otto
A C
AC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001991:Bronchitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D005260:Female; D005280:Fenoterol / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects*; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin
D013668:Technetium Tc 99m Aggregated Albumin; D005280:Fenoterol