Effect of bombesin on behaviors associated with ethanol satiation and blood ethanol levels.
The behavioral specificity and physiological significance of bombesin-induced inhibition of ethanol intake were assessed in water-deprived rats. The behavioral display accompanying suppression of 5% ethanol intake by bombesin tetradecapeptide (BBS-14, 1-4 micrograms/kg) was measured with an instantaneous time-sampling technique. Blood ethanol levels were measured after peripheral BBS-14 and bombesin nonapeptide (BBS-9) administration, and after either oral self-administration or peripheral injection of ethanol. The display accompanying BBS-14-reduced ethanol consumption differed from control in that less drinking and feeding behaviors were observed and resting increased, dose-dependently. The typical behavioral sequence of ethanol satiation was observed in all conditions. Both BBS-14 and -9 reduced blood ethanol levels when oral intake was suppressed, and BBS-14 did not affect blood ethanol levels or elimination rate when ethanol was injected. The results are compatible with an hypothesis of a functional role for endogenous bombesin-like peptides and receptors in a neuropeptide control of ethanol intake and energy balance.
Glazner
G W
GW
Department of Psychology, University of Southern Colorado, Pueblo 81001-4901.
Cannon
R L
RL
Kulkosky
P J
PJ
D000428:Alcohol Drinking / Q000187:drug effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001839:Bombesin / Q000494:pharmacology* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D000431:Ethanol / Q000097:blood*; D006120:Grooming / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014868:Water Deprivation
D000431:Ethanol; D001839:Bombesin