title: [Combination transurethral resection and systematic chemotherapy as primary treatment of infiltrating bladder tumors (pT2-pT4 NxM0)].
abstract: From Sept. 83 to Sept. 86, 20 patients (pts), mean age 65 yr, with a muscle-infiltrating bladder tumor would normally have been treated by total cystectomy. Pts were staged by intravenous urography, pelvic and abdominal CT, physical examination under general anesthesia, and deep TUR, then given neoadjuvant chemotherapy: cisplatinum and 5-FU. Courses were given every 28 days. Results were evaluated after the 3rd and 6th courses by CT, IVP and TUR. 9 pts had a histologically confirmed complete clinical response (pCR: 6 pT2, 2 pT3, 1 pT4). Median follow-up in Jan. 1988 was 30 mo. (17-52). This protocol was objectively active and well tolerated, even by elderly pts. Problems remain concerning pCR pts: (1) the respective roles of chemotherapy and TUR on the outcome; (2) prevention of recurrence (5/9 pCR).
authors.affiliation: Service d'Urologie, Hôpital Pasteur, Nice.
authors.forename: J
authors.initials: J
authors.lastname: Amiel
authors.forename: H
authors.initials: H
authors.lastname: Quintens
authors.forename: A
authors.initials: A
authors.lastname: Thyss
authors.forename: C
authors.initials: C
authors.lastname: Caldani
authors.forename: M
authors.initials: M
authors.lastname: Schneider
authors.forename: J
authors.initials: J
authors.lastname: Toubol
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000628:therapy*; D014567:Urography
chemical_list: D002945:Cisplatin; D005472:Fluorouracil
vernacular_title: Association résection trans-urétrale (RTU)-chimiothérapie systématique comme traitement initial des tumeurs infiltrantes de vessie (pT2-pT4 NxM0).