A 5-HT1-like receptor mediates a pertussis toxin-sensitive inhibition of rat ventromedial hypothalamic neurones in vitro.
5-Hydroxytryptamine (5-HT), 5-carboxamidotryptamine and 8-hydroxy-2-(di-n-propylamino)-tetralin inhibited rat ventromedial hypothalamic neurones in vitro in a concentration-dependent manner. The agonist-induced inhibition was reduced by spiperone (1 microM) and by pertussis toxin , but not by MDL 72222 (10 microM) or ketanserin (1 microM). The inhibition appeared to be mediated via 5-HT1A-receptors and a pertussis toxin-sensitive pathway.
Newberry
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Merck Sharp and Dohme Research Laboratories, Harlow, Essex.
Priestley
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T
D000818:Animals; D066298:In Vitro Techniques; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D037342:Pertussis Toxin; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D014326:Tropanes / Q000494:pharmacology; D014697:Ventromedial Hypothalamic Nucleus / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D010566:Virulence Factors, Bordetella / Q000494:pharmacology*
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D014326:Tropanes; D010566:Virulence Factors, Bordetella; D012701:Serotonin; D007650:Ketanserin; D037342:Pertussis Toxin; C042253:bemesetron