title: Synthesis of histargin and related compounds and their inhibition of enzymes.
abstract: A novel method for the synthesis of histargin and its analogs is described. It includes two kinds of N-alkylation reactions that prevent the formation of side products. The inhibition of enzymes by these compounds was also measured. Some of the compounds strongly inhibited carboxypeptidase B, carboxypeptidase A, carboxypeptidase N (kininase I), and angiotensin converting enzyme.
authors.affiliation: Central Research Laboratories, Takara Shuzo Co., Ltd., Japan.
authors.forename: M
authors.initials: M
authors.lastname: Moriguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Umeda
authors.forename: K
authors.initials: K
authors.lastname: Miyazaki
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
authors.forename: F
authors.initials: F
authors.lastname: Kojima
authors.forename: H
authors.initials: H
authors.lastname: Iinuma
authors.forename: T
authors.initials: T
authors.lastname: Aoyagi
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D002268:Carboxypeptidases / Q000037:antagonists & inhibitors*; D006146:Guanidines / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D006146:Guanidines; D007093:Imidazoles; C043476:histargin; D002268:Carboxypeptidases