title: The protective effect of Allium sativum and crataegus on isoprenaline-induced tissue necroses in rats.
abstract: Possible protective effects of Allium sativum and Crataegus--alone and in combination--on isoprenaline (isoproterenol)-induced heart, liver and pancreas damage were studied using rats as test animals. Pretreatment with Allium sativum alone, or in combination with Crataegus, resulted in protective effects on isoprenaline-induced damage of heart, liver, and pancreas. These effects proved to be dose-dependent. The following parameters were used to evaluate the protective effect: Clinical signs, qualitative histological and histoenzymatical findings, as well as quantitative microphotometric determination of enzymatic activities of succinate dehydrogenase, NADH-NBT reductase, acid phosphatase and glucose-6-phosphate dehydrogenase in cardiac, hepatic and pancreatic tissues. The underlying mechanisms are discussed. The results suggest that Allium sativum, resp. Allium sativum plus Crataegus exert a pronounced protective effect.
authors.affiliation: Gerhard-Domagk-Institute for Pathology, University of Münster, Fed. Rep. of Germany.
authors.forename: A G
authors.initials: AG
authors.lastname: Ciplea
authors.forename: K D
authors.initials: KD
authors.lastname: Richter
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D005737:Garlic; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006651:Histocytochemistry; D007545:Isoproterenol; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000473:pathology; D009246:NADH Tetrazolium Reductase / Q000378:metabolism; D009336:Necrosis / Q000517:prevention & control*; D010179:Pancreas / Q000201:enzymology / Q000473:pathology; D010783:Photometry; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D009246:NADH Tetrazolium Reductase; D000135:Acid Phosphatase; D007545:Isoproterenol