[Synthesis and biological activity of 5-phenyl-1,3,4-benzotriazepines. 13. Preparation of 2-alkylamino-5-phenyl-1,3,4-benzotriazepines as 2-thioxo-analogs and amines in the presence of heavy metal compounds].
The S-N-exchange at 2-thioxo-5-phenyl-1,3,4-benzotriazepines by alkylamines to obtain the corresponding amino-heterocycles is successful if the starting compounds react at room temperature in the presence of heavy metal compounds. Convenient conditions are given by use of lead(II)-acetate and dry dioxane as solvent. The rate of the reaction is influenced particularly by substituents of the triazepine-ring.
Morgenstern
O
O
Sektion Pharmazie der Ernst-Moritz-Arndt-Universität Greifswald.
Richter
P
P
Besch
A
A
D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D008670:Metals
D001381:Azepines; D008670:Metals
Synthese und biologische Aktivität von 5-Phenyl-1,3,4-benzotriazepinen. 13. Mitteilung: Darstellung von 2-Alkylamino-5-phenyl-1,3,4-benzotriazepinen aus 2-Thioxo-Analoga und Aminen in Gegenwart von Schwermetallverbindungen.