[Immune status in infantile autism. Correlation between the immune status, autistic symptoms and levels of serotonin].
In sixteen autistic children high values of IgG and a high level of lymphocyte stimulation with PHA were observed. Principal component analysis showed: 1) a significant correlation between basic lymphocyte mitogenic activity and the clinical symptoms opposition and hyperactivity, 2) a significant correlation between high Ig levels, high PHA stimulation responses and the main autistic symptoms (withdrawal, inaffectivity, hypoactivity, mannerism, stereotypy and negatively echolalia), 3) a significant correlation with serotonin uptake by platelets and high immunological responses. Such correlations are strongly in favor of an immunologic component in autistic disease.
Ferrari
P
P
Service de Psychothérapie, l'Enfant et de l'Adolescent, Hôpital Robert Debré, Reims.
Marescot
M R
MR
Moulias
R
R
Bursztejn
C
C
Deville Chabrolle
A
A
Thiollet
M
M
Lesourd
B
B
Braconnier
A
A
Dreux
C
C
Zarifian
E
E
D000293:Adolescent; D001321:Autistic Disorder / Q000097:blood / Q000276:immunology* / Q000523:psychology; D001792:Blood Platelets / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D008213:Lymphocyte Activation; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D012701:Serotonin / Q000097:blood*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D010835:Phytohemagglutinins; D012701:Serotonin
Etat immunitaire dans l'autisme infantile. Corrélations entre état immunitaire, symptômes autistiques et taux de sérotonine.