Antitumor principles in mosses: the first isolation and identification of maytansinoids, including a novel 15-methoxyansamitocin P-3.
A novel 15-methoxyansamitocin P-3 [2], in company with three known maytansinoids 1, 3, and 4, was isolated for the first time from two Japanese mosses, Isothecium subdiversiforme and Thamnobryum sandei. All are potent cytotoxic compounds.
Sakai
K
K
Sagami Chemical Research Center, Kanagawa, Japan.
Ichikawa
T
T
Yamada
K
K
Yamashita
M
M
Tanimoto
M
M
Hikita
A
A
Ijuin
Y
Y
Kondo
K
K
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008453:Maytansine / Q000031:analogs & derivatives / Q000302:isolation & purification* / Q000494:pharmacology; D010078:Oxazines / Q000302:isolation & purification*; D010944:Plants / Q000032:analysis
D000972:Antineoplastic Agents, Phytogenic; D010078:Oxazines; C057994:15-methoxyansamitocin P-3; D008453:Maytansine; C015682:ansamitocins