Medullary neurons mediating the inhibition of inspiration by intercostal muscle tendon organs?
Studies were conducted to test the hypothesis that nonrespiratory-modulated units are last-order interneurons mediating the effects of intercostal muscle tendon organs on medullary inspiratory neuron activity. Vagotomized, anesthetized, or decerebrate cats were used. Results show the following. 1) Afferents from different receptor types (i.e., intercostal tendon organs and chest wall cutaneous receptors) that inhibit medullary inspiratory neuron activities evoke the same units. 2) Gastrocnemius muscle group I afferent fibers evoke some of the same units as intercostal afferents but do not alter respiratory activity. 3) The "pneumotaxic center" and laryngeal nerve afferents, which inhibit medullary inspiratory activity, evoke different medullary units than intercostal afferents. 4) Evoked units are not active in spontaneously breathing cats. Additional results suggest that a few respiratory neurons near the retrofacial nucleus may be involved in the mediation of the inspiratory inhibitory effects of intercostal tendon organs. These results do not establish the mechanism by which intercostal muscle tendon organs reduces medullary inspiratory activity.
Shannon
R
R
Department of Physiology and Biophysics, College of Medicine, University of South Florida, Tampa 33612.
Bolser
D C
DC
Lindsey
B G
BG
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002415:Cats; D003655:Decerebrate State / Q000503:physiopathology; D004558:Electric Stimulation; D005071:Evoked Potentials; D007366:Intercostal Muscles / Q000294:innervation* / Q000502:physiology; D007395:Interneurons / Q000502:physiology*; D008526:Medulla Oblongata / Q000502:physiology*; D012119:Respiration; D013710:Tendons / Q000294:innervation / Q000502:physiology; D014630:Vagus Nerve / Q000502:physiology