CA 125 in the monitoring of response to chemotherapy of ovarian carcinoma.
CA 125 serum levels were assessed in 23 patients undergoing chemotherapy for advanced epithelial ovarian carcinoma (EOC). Rising, falling and unchanged levels correlated with disease in 21 out of 23 (95%) cases. Ten out of 11 patients who showed objective response to chemotherapy had a decrease in antigen levels. Two out of 3 patients with stable disease had unchanged values. Progression was always associated with rising levels. CA 125 is a reliable marker for monitoring response to chemotherapy in advanced epithelial ovarian carcinoma.
Quaranta
M
M
Laboratory Service, Oncologic Institute, Bari, Italy.
Lorusso
V
V
Coviello
M
M
Micelli
G
G
Casamassima
A
A
D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000276:immunology
D015295:Antigens, Tumor-Associated, Carbohydrate