Increased frequency of HLA-B40 in patients with paracoccidioidomycosis.
The presence of 9 HLA-A and 14 HLA-B specificities was determined in 83 patients with paracoccidioidomycosis. The finding of a higher than normal incidence of HLA-B40 (chi 2 = 10.8; corrected P less than 0.026) supports the hypothesis that genetic factors may play a role in susceptibility to paracoccidioidomycosis. The risk of developing paracoccidioidomycosis is 4.3 times higher for individuals carrying HLA-B40 than for those lacking this antigen.
Lacerda
G B
GB
Departamento de Genética, Universidade Federal do Paraná, Curitaba-PR, Brazil.
Arce-Gomez
B
B
Telles Filho
F Q
FQ
D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D015235:HLA-B Antigens / Q000032:analysis*; D059947:HLA-B40 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D010229:Paracoccidioidomycosis / Q000235:genetics / Q000276:immunology*; D012307:Risk Factors
D015235:HLA-B Antigens; D059947:HLA-B40 Antigen