[The effect of subcutaneous nitrosamine injections on the origin of tumors of the liver and their inhibition by vitamin C].
Experiments were conducted on Wistar rats for the purpose of finding out, whether peroral vitamin C application is capable of inhibiting carcinogenesis through subcutaneous injection of nitrosamine. One group of animals received injections of N-nitrosodiethylamine, while high doses of vitamin C were additionally administered to a second group in drinking water. Vitamin C only was given to a third group (control). Numerous liver carcinomas developed in response to nitrosamine application. No numerical difference was found to exist between the groups with and without vitamin C.
Wagner
W
W
Chirurgischen Klinik, Universität Erlangen-Nürnberg.
Kessler
H
H
Husemann
B
B
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage*; D004052:Diethylnitrosamine; D005260:Female; D007279:Injections, Subcutaneous; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004052:Diethylnitrosamine; D001205:Ascorbic Acid
Der Einfluss von subkutanen Nitrosamin-Injektionen auf die Genese von Tumoren der Leber und ihre Inhibition durch Vitamin C.