title: Afferent control of neuron numbers in the developing brain.
abstract: In this study we tested whether the quantitative matching of developing neuronal populations may depend on the size of the afferent supply. Partial deafferentation of the middle division of the parabigeminal nucleus (PBm) was produced before the period of naturally occurring cell death, by reducing the neuronal population of the superior colliculus following partial lesions or eye removal. The number of neurons surviving cell death in the PBm was linearly related to the number of its afferent neurons. This result supports the hypothesis that neurotrophic control by the afferent supply during the period of natural neuronal death is a major determinant of the number of neurons in the developing brain.
authors.affiliation: Instituto de Biofisica da UFRJ, Rio de Janeiro, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Linden
authors.forename: A S
authors.initials: AS
authors.lastname: Renteria
mesh_terms: D000818:Animals; D002452:Cell Count; D008636:Mesencephalon / Q000166:cytology / Q000254:growth & development*; D051381:Rats; D013477:Superior Colliculi / Q000166:cytology / Q000254:growth & development*; D014795:Visual Pathways / Q000166:cytology / Q000254:growth & development*