[Selenium and vitamin E in mucoviscidosis].
Selenium and vitamin E are two important components which protect membrane lipids from oxidative damage. Recently an abnormal fatty acid turnover in the membrane phospholipids was found in cystic fibrosis (CF). We studied vitamin E and selenium status in 26 CF children compared to a control group. we measured selenium concentration in plasma and erythrocytes using flameless atomic absorption. The measure of erythrocyte glutathione peroxidase activity allowed a functional assessment of selenium. Total plasma tocopherol concentrations (HPLC) were referred to total lipids. The vitamin E and selenium levels in not yet treated children (n = 6) were very low, with an important decrease in glutathione peroxydase activity. The antioxidative agents deficiency was mild in children with pancreatic enzyme replacement and vitamin E supplementation (n = 20). In the 2 groups, this deficiency was combined and may play a role in CF membrane abnormalities.
Foucaud
P
P
Service de Gastro-Entérologie et Nutrition Pédiatriques, Hôpital Robert-Debré, Paris.
Thérond
P
P
Marchand
M
M
Brion
F
F
Demelier
J F
JF
Navarro
J
J
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood* / Q000188:drug therapy; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007223:Infant; D008297:Male; D010184:Pancreatic Extracts / Q000627:therapeutic use; D012643:Selenium / Q000097:blood*; D014810:Vitamin E / Q000097:blood*
D010184:Pancreatic Extracts; D014810:Vitamin E; D005979:Glutathione Peroxidase; D012643:Selenium
Sélénium et vitamine E au cours de la mucoviscidose.