Selenium and vitamin E treatment of Duchenne muscular dystrophy: no effect on muscle function.
16 boys with Duchenne muscular dystrophy (DMD) were treated with sodium selenite and vitamin E for one year. One group of patients (10 boys) was examined using a battery of tests to assess muscular strength and function and cardiopulmonary function, and by CT scanning of 2 muscle groups over the 4 years prior to treatment. Six boys with DMD entered the study when the treatment was begun. Tests of muscular force and function, cardiopulmonary tests and CT-scanning were performed at the onset of treatment, and after 6 and 12 months. No beneficial effect on either muscular force or function was found during the treatment period. It is concluded that selenium and vitamin E in high doses do not improve muscle function in DMD.
Bäckman
E
E
Department of Neurophysiology, University Hospital, Linköping, Sweden.
Nylander
E
E
Johansson
I
I
Henriksson
K G
KG
Tagesson
C
C
D000293:Adolescent; D002648:Child; D006801:Humans; D008297:Male; D009132:Muscles / Q000503:physiopathology*; D009136:Muscular Dystrophies / Q000188:drug therapy* / Q000503:physiopathology; D012643:Selenium / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*
D014810:Vitamin E; D012643:Selenium