title: Synthesis of some derivatives of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(piperazin-1-yl)-3-quino linecarbo xylic acid (norfloxacin) as potential antibacterial agents.
abstract: Twelve new fluoroquinolones, structurally related to norfloxacin, have been synthesized in order to investigate the effect of substituents at the secondary nitrogen of the piperazine ring on antimicrobial activity. The new substances (carbamates, isoureas, guanidines, ureas and cyanamides) tested on a variety of gram-positive and gram-negative organisms showed lower activity than the model compound.
authors.affiliation: Department of Chemistry, Pierrel S.p.A., Milano, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pappalardo
authors.forename: A
authors.initials: A
authors.lastname: Omodei-Salè
authors.forename: G
authors.initials: G
authors.lastname: Zanuso
authors.forename: A
authors.initials: A
authors.lastname: Gutierrez
authors.forename: L
authors.initials: L
authors.lastname: Moujir
authors.forename: F G
authors.initials: FG
authors.lastname: De Las Heras
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002939:Ciprofloxacin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000031:analogs & derivatives* / Q000138:chemical synthesis
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D009643:Norfloxacin