In vivo evidence for cholesterol ester and triglyceride exchange between high density lipoprotein and infused triglyceride rich particles in abetalipoproteinemia.
Abetalipoproteinemia is characterized by the absence of chylomicrons, very low density and low density lipoproteins from the plasma. To study neutral lipid exchange between lipoproteins in vivo a chylomicron model, Intralipid R, was infused in an abetalipoproteinemic patient. During a three hour infusion of 250 mg/kg/hr after a priming dose of 100 mg/kg triglyceride, 8% of the triglyceride mass of Intralipid was replaced by cholesterolester, while 8% of the cholesterylester mass was replaced by triglyceride in high density lipoproteins. Thus, the exchange of cholesterylester and triglyceride between high density lipoprotein and triglyceride rich particles in vivo was directly demonstrated in the absence of apolipoprotein B.
Erkelens
D W
DW
Department of Internal Medicine, University Hospital Utrecht, Netherlands.
Dullaart
R P
RP
D000012:Abetalipoproteinemia / Q000097:blood*; D000328:Adult; D001692:Biological Transport; D002784:Cholesterol / Q000097:blood; D002788:Cholesterol Esters / Q000097:blood*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D014280:Triglycerides / Q000097:blood*
D002788:Cholesterol Esters; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol