Second infections in AIDS. A new facet to the immune mechanism.
The lack of secondary infections or the delay in their appearance in immunodeficient individuals (specifically AIDS patients) previously immunized prior to their immune deficit points to an as yet overlooked mechanism in the immune response. It is proposed that on second exposure to the antigen (Ag) there is a unique Ag presentation that alters the Ag in such a way as to induced a state of tolerance.
Kelly
T A
TA
Laboure College, Boston, MA 02124.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology; D000941:Antigens / Q000008:administration & dosage; D006801:Humans; D007108:Immune Tolerance; D007114:Immunization; D008954:Models, Biological; D009894:Opportunistic Infections / Q000150:complications* / Q000276:immunology
D000941:Antigens