title: [Basic therapy of chronic inflammatory joint diseases with D-penicillamine and disorders of wound healing in rheumatoid orthopedic interventions].
abstract: In the past, D-penicillamine has been thought to cause wound healing disturbances due to its influence on connective tissue. A series of 217 operations in 150 patients with rheumatoid arthritis on D-penicillamine treatment were performed and compared with controls (106 operations in 86 patients with rheumatoid arthritis). It was shown that disturbances of wound healing were less in patients on D-penicillamine therapy (12.4%) than in patients who did not receive D-penicillamine (18.9%). A perioperative withdrawal of D-penicillamine therefore does not seem justified.
authors.affiliation: I. Orthopädische Klinik des BRK-Rheumazentrums Bad Abbach.
authors.forename: J
authors.initials: J
authors.lastname: Zacher
authors.forename: S
authors.initials: S
authors.lastname: Späth
authors.forename: D
authors.initials: D
authors.lastname: Wessinghage
authors.forename: G
authors.initials: G
authors.lastname: Waertel
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D007596:Joints / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use; D011183:Postoperative Complications / Q000209:etiology; D011446:Prospective Studies; D000074402:Synovectomy; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010396:Penicillamine
vernacular_title: Basistherapie der chronisch-entzündlichen Gelenkerkrankungen mit D-Penicillamin und Wundheilungsstörungen bei rheumaorthopädischen Eingriffen.