Brain pH in migraine: an in vivo phosphorus-31 magnetic resonance spectroscopy study.
The intracellular pH (pHi) of cerebral cortex was measured in migraine patients by use of in vivo phosphorus-31 NMR spectroscopy. No changes in pHi were measured during a migraine attack. The long-standing concept that the headache of migraine is due to cerebral vasodilation induced by prodromal vasospasm-induced ischemic acidosis is not substantiated.
Welch
K M
KM
Department of Neurology, Henry Ford Hospital, Detroit, MI 48202.
Levine
S R
SR
D'Andrea
G
G
Helpern
J A
JA
D000328:Adult; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D008881:Migraine Disorders / Q000378:metabolism*