Protective effect of tulobuterol on methacholine-induced bronchospasm in asthmatic children.
In a single-blind, placebo-controlled trial 19 asthmatic children aged 10-14 years were studied during a stable phase of the disease. All patients were tested with a methacholine inhalation test on two consecutive days, on the first day after oral administration of a placebo, and on the second day following an oral dose of tulobuterol HCl. The cumulative methacholine dose required to produce at least a 20% decrease in FEV1 was significantly higher after tulobuterol than after the placebo. It is concluded that tulobuterol HCl reduces methacholine-induced bronchospasm in children.
Riba
A
A
Pulmonary Section, General Hospital Vall d'Hebron, Barcelona, Spain.
Dal-Re
R
R
Morell
F
F
D000293:Adolescent; D001249:Asthma / Q000503:physiopathology*; D001986:Bronchial Spasm / Q000139:chemically induced / Q000517:prevention & control*; D001993:Bronchodilator Agents / Q000494:pharmacology*; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects; D013726:Terbutaline / Q000031:analogs & derivatives* / Q000494:pharmacology
D001993:Bronchodilator Agents; D008688:Methacholine Compounds; C010809:tulobuterol; D013726:Terbutaline