Undetectable peripheral blood CFU-GM as a prognostic indicator in myelodysplastic syndrome.
The survival of MDS patients without detectable circulating CFU-GM (median = 188 days) was significantly lower than those in whose peripheral blood CFU-GM were detected (median greater than 1000 days) (p less than 0.01). About half of those with detectable PB-CFU-GM died within 2 yr whilst the remainder survived more than ca 3 yr. There was no significant difference in the distribution of patients having 0-5% and greater than 5% marrow blast cells within the three groups.
Tennant
G B
GB
Department of Haematology, University of Wales College of Medicine, Cardiff, U.K.
Jacobs
A
A
D000753:Anemia, Refractory / Q000097:blood / Q000401:mortality*; D000754:Anemia, Refractory, with Excess of Blasts / Q000097:blood / Q000401:mortality*; D006098:Granulocytes / Q000473:pathology*; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D007958:Leukocyte Count; D008264:Macrophages / Q000473:pathology*; D011379:Prognosis