Colorimetric determination of tobramycin in parenteral solutions.
A colorimetric method based on a reaction between tobramycin and alkaline copper sulphate solution has been proposed to quantify tobramycin in injections. The excipients present and normal saline did not interfere with the assay procedure. A tobramycin sample which was decomposed using either sulphuric acid or sodium hydroxide solution indicated fairly good stability on both sides of the pH scale.
Das Gupta
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V
Department of Pharmaceutics, University of Houston, TX 77030.
D003124:Colorimetry / Q000379:methods*; D005947:Glucose; D010636:Phenols; D012965:Sodium Chloride; D012996:Solutions; D014031:Tobramycin / Q000032:analysis*
D010636:Phenols; D012996:Solutions; D012965:Sodium Chloride; D005947:Glucose; D014031:Tobramycin