title: [Anti-arrhythmic effects of intravenous magnesium sulfate in paroxysmal supraventricular tachycardia].
abstract: The anti-arrhythmic effects of intravenous magnesium sulfate, on bouts of supraventricular tachycardia (SVT) secondary to reentry phenomenon, are evaluated in twelve patients undergoing an electrophysiological testing, because of paroxysmal SVT, the pathway of which is an intranodal reentry (eight patients) or includes an atrio-ventricular accessory route (orthodromic SVT: four patients). At the completion of the basic testing, a stable SVT is induced and an intravenous bolus of 3 grams of magnesium sulfate is administered in three minutes. The length of the SVT cycle is significantly increased from 349 +/- 71 ms to 394 +/- 70 ms (p 0.001). The injection of magnesium relieves the SVT in less than five minutes in three patients (intranodal reentry: two cases; accessory pathway: one case), or an efficacy of 25 p. cent. No incident is reported following administration of the product; but the functional tolerance may be considered as poor, mainly consisting of flushing sensations of brief duration. This study demonstrates the antiarrhythmic properties of intravenous magnesium sulfate during bouts of SVT; however, its efficacy appears moderate at the dose mentioned.
authors.affiliation: Service de Cardiologie, CHU Morvan, Brest.
authors.forename: Y
authors.initials: Y
authors.lastname: Etienne
authors.forename: J J
authors.initials: JJ
authors.lastname: Blanc
authors.forename: J
authors.initials: J
authors.lastname: Boschat
authors.forename: J
authors.initials: J
authors.lastname: Le Potier
authors.forename: Y
authors.initials: Y
authors.lastname: Jobic
authors.forename: O
authors.initials: O
authors.lastname: Le Grand
authors.forename: P
authors.initials: P
authors.lastname: Penther
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013617:Tachycardia, Supraventricular / Q000188:drug therapy*
chemical_list: D008278:Magnesium Sulfate
vernacular_title: Effets antiarythmiques du sulfate de magnésium intraveineux dans les tachycardies supraventriculaires paroxystiques.