title: The cause of ischaemic nocturnal rest pain.
abstract: Adipose tissue blood flow in the forefoot was measured simultaneously with mean systemic arterial blood pressure over 24 hours in 8 patients (15 feet) with different degrees of arterial insufficiency. Mean systemic arterial pressure decreased by 19 +/- 9% during sleep, irrespective of symptomatology. In two limbs, with a normal peripheral circulation, blood flow decreased by 8 +/- 7%. In five limbs with arterial insufficiency, but no rest pain, blood flow decreased by 16 +/- 8% and in eight limbs with ischaemic nocturnal rest pain blood flow was reduced by 32 +/- 12% during sleep. It is concluded that nocturnal hypotension is a major factor in the production of nocturnal ischaemic rest pain.
authors.affiliation: Dept of Surgery M, Bispebjerg Hospital, Copenhagen, Denmark.
authors.forename: R
authors.initials: R
authors.lastname: Jelnes
authors.forename: J
authors.initials: J
authors.lastname: Bülow
authors.forename: K H
authors.initials: KH
authors.lastname: Tønnesen
authors.forename: N A
authors.initials: NA
authors.lastname: Lassen
authors.forename: P
authors.initials: P
authors.lastname: Holstein
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002940:Circadian Rhythm; D006801:Humans; D007511:Ischemia / Q000150:complications / Q000503:physiopathology*; D007866:Leg / Q000098:blood supply*; D008875:Middle Aged; D010146:Pain / Q000209:etiology / Q000503:physiopathology*; D012039:Regional Blood Flow; D012146:Rest; D013484:Supination