title: Microangiopathy with encephalopathy, hearing loss and retinal arteriolar occlusions: two new cases.
abstract: Two young women developed encephalopathy, hearing loss and retinal arteriolar occlusions. Their behaviour became immature and cognitive functions were severely impaired. One of the patients underwent brain biopsy, which showed several microinfarcts in both white and grey matter and microangiopathic changes, with thickened arteriolar segments staining intensely for laminin and fibronectin. These findings support the concept of a new type of microangiopathy involving the brain, inner ear and retina.
authors.affiliation: Department of Neurology, University of Helsinki, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Heiskala
authors.forename: H
authors.initials: H
authors.lastname: Somer
authors.forename: J
authors.initials: J
authors.lastname: Kovanen
authors.forename: E
authors.initials: E
authors.lastname: Poutiainen
authors.forename: H
authors.initials: H
authors.lastname: Karli
authors.forename: M
authors.initials: M
authors.lastname: Haltia
mesh_terms: D000328:Adult; D001157:Arterial Occlusive Diseases / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D001921:Brain / Q000473:pathology; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D005260:Female; D034381:Hearing Loss / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D011859:Radiography; D012160:Retina / Q000098:blood supply*