Qualitative discrimination between cocaine and amphetamine in rats.
After extensive training, rats discriminated amphetamine (1 mg/kg) from cocaine (either 5, 10 or 12.5 mg/kg) in a two lever drug versus drug discrimination task. In tests with saline, selection of the cocaine lever occurred in animals trained with 5 mg/kg cocaine. At higher training doses of cocaine, a (dose-related) tendency for lever selection to be equally distributed between the two levers was seen after saline injections. These data show that, at specific pairs of doses of cocaine and amphetamine, a qualitative discrimination between the drugs develops.
Goudie
A
A
Department of Psychology, University of Liverpool, U.K.
Reid
D
D
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051381:Rats; D012055:Reinforcement Schedule
D000661:Amphetamine; D003042:Cocaine