The circadian cycle effects of DSIP on colonic temperature, blood pressure, and heart rate in control and area postrema-lesioned rats.
Groups of control and Area Postrema rats were treated with 0.1 mg/kg, i.p., DSIP or with saline, at 06:00, 09:00, 12:00, 15:00, 18:00, 21:00, 24:00, and at 03:00. Colonic temperature, blood pressure, and heart rate were measured 30 min after treatment. DSIP induced a shift in the hyperthermic cycle of control rats, but was unable to modify the noncyclic hypothermia found among Area Postrema-lesioned rats. Furthermore, DSIP caused a decrease in the blood pressure level of control rats, but had no such effect on the already depressed level of blood pressure in the Area Postrema-lesioned rats. Finally, DSIP decreased the heart rate of control rats and significantly antagonized the elevated heart rate observed in the Area Postrema-lesioned rats. The data do not permit us directly to relate the physiological change induced by DSIP to its sleep-promoting effects.
Yehuda
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S
Department of Psychology, Bar-Ilan University, Ramat-Gan, Israel.
Caspy
T
T
Carasso
R L
RL
D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects*; D002552:Cerebral Ventricles / Q000502:physiology; D002940:Circadian Rhythm; D003106:Colon / Q000187:drug effects; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003701:Delta Sleep-Inducing Peptide