The relationship between the response to growth hormone therapy and pre-treatment growth hormone secretory status.
In 35 children (22 M, 13 F) aged between 5.3 years and 10.3 years who received Somatrem therapy for 1 year there was a curvi-linear relationship between pretreatment GH sensory status (x) and response (y) (change in height velocity standard deviation score (SDS)) to therapy described by the equation y = A + B (e-Cx). A, B and C are constants. Dose of GH administered was found to be an important additional factor in determining response to therapy. This was confirmed by stepwise multiple regression which resulted in a correlation coefficient of 0.74. These data suggest that in the assessment of response to GH therapy, pretreatment height velocity and/or GH secretory status as well as dose and frequency of GH administration need to be taken into account.
Hindmarsh
P C
PC
Endocrine Unit, Middlesex Hospital, London, UK.
Smith
P J
PJ
Pringle
P J
PJ
Brook
C G
CG
D001827:Body Height / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy*; D013006:Growth Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D019382:Human Growth Hormone; D006801:Humans; D008297:Male
D019382:Human Growth Hormone; D013006:Growth Hormone