Application of allyloxycarbonyl group as a protecting group to oligodeoxyribonucleotide synthesis.
The allyloxycarbonyl (AOC) group, known as an efficient amino protective group in solution-phase synthesis of nucleotides, has been used for the first time in solid-phase oligonucleotide synthesis. The efficiency of the new procedure is compared with that of the conventional N-acyl protection.
Mitsuhira
Y
Y
Biological Science Institute, Nippon Zeon Co. Ltd., Kanagawa, Japan.
Tahara
S
S
Goto
K
K
Hayakawa
Y
Y
Noyori
R
R
D000498:Allyl Compounds; D001483:Base Sequence; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000302:isolation & purification
D000498:Allyl Compounds; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides