Circadian rhythms are suppressed in hyperproliferative mouse epidermis.
We examined the chronically hyperproliferative epidermis of the asebia (ab/ab) mouse for circadian rhythms in cell proliferation and in the rate of DNA synthesis, which is related to S phase duration. The curve for the circadian rhythm in cell proliferation for asebia epidermis was suppressed and distorted in comparison to that for BALB/cJ epidermis and in comparison to a composite curve produced by averaging the results from ten other published studies.
Brown
W R
WR
Department of Medicine, University of Toronto, Ontario, Canada.
Furukawa
R D
RD
Ramsay
C A
CA
D000818:Animals; D002455:Cell Division; D002940:Circadian Rhythm; D000078404:Epidermal Cells; D004947:Esophagus / Q000166:cytology; D006965:Hyperplasia; D007399:Interphase; D051379:Mice; D008807:Mice, Inbred BALB C; D008817:Mice, Mutant Strains