title: The in vivo genotoxic properties of the nitrosopeptide N-(N-acetyl-L-prolyl)-N-nitrosoglycine.
abstract: The N-nitrosopeptide N-(N-acetyl-L-prolyl)-N-nitrosoglycine (APNG) was investigated for in vivo genotoxicity using the dominant lethal assay and the micronucleus test in mice, and the bone marrow test in rats. APNG was shown to cause definite genetic effects in the mouse but a much lesser effect in the rat, indicating that APNG is a genotoxic agent in vivo.
authors.affiliation: British Industrial Biological Research Association, Carshalton, Surrey, England.
authors.forename: S D
authors.initials: SD
authors.lastname: Blowers
authors.forename: D
authors.initials: D
authors.lastname: Anderson
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D008297:Male; D008677:Metaphase / Q000187:drug effects; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens; D009602:Nitrosamines / Q000633:toxicity*; D051381:Rats
chemical_list: D009153:Mutagens; D009602:Nitrosamines; C045273:N-(N-acetylprolyl)-N-nitrosoglycine