title: Multicentric reticulohistiocytosis.
abstract: This is a short report on the first case of a multicentric reticulohistiocytosis diagnosed at Middle Road Hospital in 1987. He presented with multiple reddish brown papules and nodules but without arthritis. Systemic review did not show any associated malignancies. Treatment with methotrexate has not been useful. Multicentric Reticulohistiocytosis is a proliferative histiocytic disorder that is benign. It is characterised by a dermatoarthritis, extensive red nodule and a rheumatoid-like arthritis. Histologically, multinucleated giant cells in ground glass cytoplasma and mononuclear histiocytes form the granulomatous infiltrate that invades the dermis, mucosa, synovium and others--bone, plasma, pericardium etc.
authors.affiliation: Middle Road Hospital, Singapore.
authors.forename: Y C
authors.initials: YC
authors.lastname: Giam
authors.forename: B H
authors.initials: BH
authors.lastname: Ong
mesh_terms: D006644:Histiocytes / Q000473:pathology; D006801:Humans; D008206:Lymphatic Diseases / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology*