Releasable, non-neuronal GABA pool in rat stomach.
The uptake and K+-evoked release of [3H] gamma-aminobutyric acid (GABA) was examined in tissue slices from rat gastric antrum. Active [3H]GABA accumulation was observed that could only be partially inhibited by L-diaminobutyric acid (L-DABA), a blocker of neuronal GABA uptake. The L-DABA-insensitive uptake component was saturable, sodium-dependent and of high affinity. Moreover, [3H]GABA could be released from this L-DABA-resistant pool by a high K+ concentration. It is concluded that a releasable, non-neuronal GABA pool, which may have some functional significance, is present in the gastric antrum.
Erdö
S L
SL
Pharmacological Research Centre, Chemical Works of G. Richter Ltd., Budapest, Hungary.
Wolff
J R
JR
D000613:Aminobutyrates / Q000494:pharmacology; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D011706:Pyloric Antrum / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000613:Aminobutyrates; C005959:2,4-diaminobutyric acid; D005680:gamma-Aminobutyric Acid