title: Levamisole pharmacokinetics and bioavailability in dogs.
abstract: Levamisole was given intravenously and orally (with and without food) to six dogs. All dogs reacted adversely to intravenous dosage and one died. For the remaining five, intravenous data fitted a one compartment model with first order elimination and a mean half-time of elimination of 1.8 hours. In fasting dogs drug absorption from the gut was rapid and the mean fraction absorbed (F) was 0.64. When levamisole was given with food, drug bioavailability was impaired, as absorption was slowed and possibly reduced (F = 0.49). The effect of ingesta on bioavailability of levamisole could affect treatment efficacy and side effects.
authors.affiliation: Department of Veterinary Clinical Studies, University of Sydney, New South Wales, Australia.
authors.forename: A D
authors.initials: AD
authors.lastname: Watson
authors.forename: N C
authors.initials: NC
authors.lastname: Sangster
authors.forename: D B
authors.initials: DB
authors.lastname: Church
authors.forename: H
authors.initials: H
authors.lastname: Van Gogh
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004285:Dogs / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D007408:Intestinal Absorption / Q000187:drug effects*; D007978:Levamisole / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male
chemical_list: D007978:Levamisole