Cistiside-M, a new protective agent.
The toxicological and radiopharmacological properties of the agent Cistiside-M (2-mercaptoethylamine adenosine-5-phosphate) were investigated on male mice, lines C57Bl and H. The compound was administered intraperitoneally in doses from 1000 to 125 mg/kg, 15 min prior to lethal gamma-irradiation using a 137Cs source in the 6 to 15 Gy range. The radioprotective effect was assessed by the integral indices of 30-day survival, mean survival time, coefficient of protection alpha, S30 and the dose-reduction factor (DRF). The compound was characterized by low toxicity and good antiradiation effect in a wide dose range. Maximum degree of radioprotection (75% survival) was established when the agent was administered in a dose of 1000 mg/kg. DRF was 1.6. The dose of 250 mg/kg was interesting--with 50% survival rate and increase of the therapeutic index to 5.6. The low toxicity and the considerable radioprotective effect of the compound are due to its complex structure.
Minkova
M
M
Research Institute of Nuclear Medicine, Radiobiology and Radiation Hygiene, Medical Academy, Sofia.
Pantev
T
T
Georgieva
R
R
D000249:Adenosine Monophosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D005720:Gamma Rays; D007928:Lethal Dose 50; D008297:Male; D008624:Mercaptoethylamines / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011833:Radiation Injuries, Experimental; D011837:Radiation-Protective Agents; D013997:Time Factors
D008624:Mercaptoethylamines; D011837:Radiation-Protective Agents; D000249:Adenosine Monophosphate; C058521:cisticide M