title: Genetic evidence that the sans fille locus is involved in Drosophila sex determination.
abstract: Females homozygous for sans fille1621 (= fs(1)1621) have an abnormal germ line. Instead of producing eggs, the germ-line cells proliferate forming ovarian tumors or excessive numbers of nurse cells. The Sex-lethal gene product(s) regulate the branch point of the dosage compensation and sex determination pathways in the soma. The role of Sex-lethal in the germ line is not clear but the germ line of females homozygous for female sterile Sex-lethal alleles or germ-line clones of loss-of-function alleles are characterized by ovarian tumors. Females heterozygous for sans fille1621 or Sex-lethal are phenotypically wild type with respect to viability and fertility but females trans-heterozygous for sans fille1621 and Sex-lethal show ovarian tumors, somatic sexual transformations, and greatly reduced viability.
authors.affiliation: Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
authors.forename: B
authors.initials: B
authors.lastname: Oliver
authors.forename: N
authors.initials: N
authors.lastname: Perrimon
authors.forename: A P
authors.initials: AP
authors.lastname: Mahowald
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004330:Drosophila / Q000235:genetics*; D005260:Female; D005804:Genes, Lethal; D005809:Genes, Regulator; D005816:Genetic Complementation Test; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D008297:Male; D009154:Mutation; D010641:Phenotype; D012732:Sex Determination Analysis; D013696:Temperature