[Biotransformation of denaverin (Spasmalgan) in the rat].
After oral application of denaverine hydrochloride to rats (200-250 mg/kg) 12 metabolites have been detectecd in urine. Besides the unchanged drug, 8 metabolites were identified by MS as 2,2-diphenyl-(2-dimethylaminoethyl) acetate (3), diphenylacetic (5) and benzilic acid (6); methyl-and ethyl [2-(2-ethylbutoxy)-2,2-diphenyl]acetate (7, 11), methylbenzilate (10), N-demethyl-1 (12) and 3,3-diphenyl-morpholin-2-one (13). 6 and the metabonate 13 represent the main metabolic products. Compounds 7 and 11 indicate the metabolic pathway about an alkoxybenzilic acid (4). Phenols resp. conjugates were not detected.
Göber
B
B
Sektion Chemie, Wissenschaftsbereich Pharmazie, Humboldt-Universität zu Berlin.
Lisowski
H
H
Friese
D
D
Franke
P
P
D000700:Analgesics / Q000493:pharmacokinetics*; D000818:Animals; D001561:Benzilates / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D001561:Benzilates; C001967:denaverine
Biotransformation von Denaverin (Spasmalgan) bei der Ratte.