Clinical assay of serum SCC-Ag in urothelial cancers.
Serum squamous cell carcinoma related antigen (SCC-Ag) values were determined in 86 patients with urothelial cancers. Mean +/- standard deviation for serum SCC-Ag, was 3.4 +/- 0.98 ng/ml and positive values (greater than 2.0 ng/ml) were found in 27%. Neither pathological stage nor cell grade of the urothelial cancer showed any relation to serum SCC-Ag. Serum SCC-Ag. changed parallel to the clinical course. These results suggest that, as there is no specific tumor marker in urothelial cancer, serum SCC-Ag. may be a useful aid in diagnosing cancer and monitoring these patients. Used together with another non-specific marker, an increase in the accuracy of diagnosis of these malignancies can be expected.
Takahashi
Y
Y
Department of Urology, Gifu University School of Medicine, Japan.
Shinoda
I
I
Takeuchi
T
T
Kuriyama
M
M
Ban
Y
Y
Kawada
Y
Y
D000230:Adenocarcinoma / Q000175:diagnosis; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis; D005260:Female; D005834:Genital Neoplasms, Male / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015843:Serpins; D014571:Urologic Neoplasms / Q000175:diagnosis*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015843:Serpins; C051072:squamous cell carcinoma-related antigen