title: Synthesis and beta-lactamase inhibitory activity of 9-(2-amidoethenylthio)-9-deoxy derivatives of clavulanic acid.
abstract: The reaction of activated derivatives of clavulanic acid with substituted amidoethenyl thiolates to give 9-(2-amidoethenylthio)-9-deoxy derivatives is described; the antibacterial/synergistic and beta-lactamase inhibitory activities of the thioethers and their corresponding sulfoxides and sulfones are compared.
authors.affiliation: Beecham Pharmaceuticals Research Division, Chemotherapeutic Research Centre, Betchworth, Surrey, England.
authors.forename: G
authors.initials: G
authors.lastname: Brooks
authors.forename: K
authors.initials: K
authors.lastname: Coleman
authors.forename: J S
authors.initials: JS
authors.lastname: Davies
authors.forename: P A
authors.initials: PA
authors.lastname: Hunter
mesh_terms: D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000031:analogs & derivatives* / Q000494:pharmacology; D065093:beta-Lactamase Inhibitors
chemical_list: D002969:Clavulanic Acids; D065093:beta-Lactamase Inhibitors; D019818:Clavulanic Acid