title: Direct high-performance liquid chromatographic resolution of dihydropyridine enantiomers.
abstract: A direct high-performance liquid chromatographic enantioseparation on a chiral stationary phase using a protein as chiral selector was achieved for some dihydropyridines with different structural groups (amine, amide, acid and hydroxyl groups). The protein involved was alpha 1-acid glycoprotein and the work was mainly carried out with an EnantioPac column. An improved version of this chiral column (Chiral-AGP) was compared with the previous one and gave interesting results.
authors.affiliation: Recherche Syntex France, Leuville-sur-Orge, Montlhéry.
authors.forename: E
authors.initials: E
authors.lastname: Delee
authors.forename: I
authors.initials: I
authors.lastname: Jullien
authors.forename: L
authors.initials: L
authors.lastname: Le Garrec
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004095:Dihydropyridines / Q000302:isolation & purification*; D006863:Hydrogen-Ion Concentration; D009961:Orosomucoid / Q000032:analysis; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D004095:Dihydropyridines; D009961:Orosomucoid