Accessory cell paradox: monocytes enhance or inhibit lectin-mediated human T-lymphocyte proliferation depending on the choice of mitogen.
Monocytes suppressed the mitogenic response of human T lymphocytes to the lectin from Datura stramonium but enhanced the mitogenic response of the same lymphocytes to wheat germ agglutinin under identical culture conditions. The inhibitory action was probably cell-mediated, but was not the result of cytotoxicity. The stimulative activity could be replaced by cell-free conditioned medium.
Kilpatrick
D C
DC
Blood Transfusion Centre, Royal Infirmary, Edinburgh, UK.
D006801:Humans; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008934:Mitogens / Q000494:pharmacology*; D009000:Monocytes / Q000502:physiology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology*
D037102:Lectins; D008934:Mitogens; D010835:Phytohemagglutinins