title: An investigation of the metabolism of S-carboxymethyl-L-cysteine in man using a novel HPLC-ECD method.
abstract: The metabolism of an oral dose of S-carboxymethyl-L-cysteine (SCMC) in man has been studied; the quantitative determination of SCMC, S-methyl-L-cysteine (SMC) and their sulphoxide metabolites (SCMCO and SMCO), in urine, was carried out using high performance liquid chromatography (HPLC) with electrochemical detection (ECD); the possibility of stereospecific sulphoxidation was investigated.
authors.affiliation: Department of Pharmacy, Queen's University of Belfast, Northern Ireland.
authors.forename: E F
authors.initials: EF
authors.lastname: Karim
authors.forename: J S
authors.initials: JS
authors.lastname: Millership
authors.forename: D J
authors.initials: DJ
authors.lastname: Temple
authors.forename: A D
authors.initials: AD
authors.lastname: Woolfson
mesh_terms: D002233:Carbocysteine / Q000032:analysis / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003545:Cysteine / Q000031:analogs & derivatives* / Q000032:analysis; D006801:Humans; D008297:Male; D013454:Sulfoxides / Q000032:analysis
chemical_list: D013454:Sulfoxides; D002233:Carbocysteine; C008425:S-methylcysteine; D003545:Cysteine