title: A mapped set of DNA markers for human chromosome 15.
abstract: A primary genetic linkage map for human chromosome 15 has been constructed from 16 arbitrary DNA markers genotyped in 59 large reference families. The map spans a genetic distance of 146 cM in males and 187 cM in females. The ratio of female/male genetic distance was approximately 2.1 overall within the region of the chromosome covered by our map, but three segments showed a significant male excess in recombination frequency. A subset of seven of the linked markers would be enough to detect linkage of a genetic defect within the mapped region of chromosome 15, if at least 48 phase-known meioses in affected families were available for analysis.
authors.affiliation: Howard Hughes Medical Institute, University of Utah Medical School, Salt Lake City 84132.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Lathrop
authors.forename: P
authors.initials: P
authors.lastname: O'Connell
authors.forename: M
authors.initials: M
authors.lastname: Leppert
authors.forename: J M
authors.initials: JM
authors.lastname: Lalouel
authors.forename: R
authors.initials: R
authors.lastname: White
mesh_terms: D000483:Alleles; D002460:Cell Line; D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D004247:DNA / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers / Q000032:analysis; D006579:Heterozygote; D006801:Humans; D008297:Male; D010957:Plasmids; D014589:Utah
chemical_list: D005819:Genetic Markers; D004247:DNA