Compounds with potential antitumor activity. VI--2-Alkyl-3-[2-(1,3,4-thiadiazolyl)]-4-thiazolidinones.
The antitumor activity of a series of 2-alkyl-3-[2-(1,3,4-thiadiazolyl)]-4-thiazolidinones was tested against the leukemic P 388 tumor system in mice. Only compounds (V-VII) showed significant activity.
Grasso
S
S
Dipartimento Farmaco-Chimico, Cattedra di Chimica Farmaceutica, Università di Messina, Italy.
Chimirri
A
A
Monforte
P
P
Fenech
G
G
Zappalà
M
M
Monforte
A M
AM
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007941:Leukemia P388 / Q000188:drug therapy; D008055:Lipids / Q000032:analysis; D051379:Mice; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D008055:Lipids; D013830:Thiadiazoles