Cyclosporin A inhibits smooth muscle proliferation in the vascular response to injury.
The arterial response to injury is dominated by proliferation of smooth muscle cells and infiltration of blood-borne cells in the vascular intima. Arterial smooth muscle cell proliferation is under growth factor control, but how this regulation operates in vivo is unclear. We studied the effect on arterial response to mechanical injury of cyclosporin A, a drug that inhibits T-lymphocyte activation. Cyclosporin A treatment at surgery caused a persistent inhibition of the intimal proliferative lesion. Cyclosporin A also inhibited expression of Ia antigens on smooth muscle cells in situ but had no direct effects on smooth muscle cell proliferation in culture. Therefore, the inhibition of intimal cell proliferation appears to be mediated via the immune system.
Jonasson
L
L
Department of Clinical Chemistry, Gothenburg University, Sahlgren's Hospital, Sweden.
Holm
J
J
Hansson
G K
GK
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D002339:Carotid Arteries / Q000473:pathology; D020212:Carotid Artery Injuries; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003524:Cyclosporins / Q000494:pharmacology*; D003864:Depression, Chemical; D004730:Endothelium, Vascular / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D003524:Cyclosporins