title: Complement is not activated in ABO-haemolytic disease of the newborn.
abstract: We studied the lysis in vitro of group A red cells by IgG anti-A. IgG anti-A, which strongly lysed A red cells from adults, did not lyse A red cells from cord blood, if fresh cord serum from a child with blood group AB was used as a source of complement. In cases of haemolytic disease of the newborn due to A-O or B-O antagonism with a positive direct antiglobulin test with anti-IgG serum, the red cells did not react with anti-complement sera. Apparently, complement is also not activated in vivo in case of A-O haemolytic disease of the newborn.
authors.affiliation: Central Laboratory the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
authors.forename: H A
authors.initials: HA
authors.lastname: Brouwers
authors.forename: M A
authors.initials: MA
authors.lastname: Overbeeke
authors.forename: E
authors.initials: E
authors.lastname: Huiskes
authors.forename: M J
authors.initials: MJ
authors.lastname: Bos
authors.forename: W H
authors.initials: WH
authors.lastname: Ouwehand
authors.forename: C P
authors.initials: CP
authors.lastname: Engelfriet
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D003167:Complement Activation; D003298:Coombs Test; D004899:Erythroblastosis, Fetal / Q000097:blood / Q000276:immunology*; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007231:Infant, Newborn
chemical_list: D000017:ABO Blood-Group System; D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; C048844:anti-IgG