Regulation of cell division and malignant transformation.
The problem of regulation of cell division is essentially a problem of understanding regulation of transition from the resting state of a cell to the dividing state and vice versa. In malignancy the ability to revert back to a normal resting state is impaired. A model is presented which attempts to explain the control of the above transitions through control of uptake of essential nutrients by a transport-inhibitory protein. Experimental evidence in favour of the model is given.
Bhargava
P M
PM
Centre for Cellular & Molecular Biology, Hyderabad, India.
Chandani
S A
SA
D000818:Animals; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D007399:Interphase; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology; D008954:Models, Biological; D009363:Neoplasm Proteins / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats
D009363:Neoplasm Proteins; D011506:Proteins