title: Immunohistochemical characterization of a B-cell signet ring cell lymphoma. Report of a case.
abstract: Signet ring cell lymphoma is a non-Hodgkin's lymphoma, characterized by neoplastic lymphoid signet ring cells very similar to epithelial mucin producing cells. We describe here a case of signet ring cell lymphoma in which the immunophenotypic markers of signet ring cells parallel those of plasma cells, being intensively T10+ (CD 38), weakly HLA-DR+, and To15 (CD 22) and T200 (CD 45) negative. The morphologic and immunohistochemical features of the case and the main differential diagnosis are preceded by a review of the literature.
authors.affiliation: Dept. of Human Biopathology, University La Sapienza, Roma, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Uccini
authors.forename: E
authors.initials: E
authors.lastname: Pescarmona
authors.forename: L P
authors.initials: LP
authors.lastname: Ruco
authors.forename: C D
authors.initials: CD
authors.lastname: Baroni
authors.forename: B
authors.initials: B
authors.lastname: Monarca
authors.forename: A
authors.initials: A
authors.lastname: Modesti
mesh_terms: D001402:B-Lymphocytes / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged