Simultaneous high-performance liquid chromatographic determination of propoxyphene and acetaminophen in pharmaceutical preparations.
A normal-phase high-performance liquid chromatographic method, using a 3.3 cm x 4.6 mm silica column (3 microns packing) and an ammonium hydroxide-methanol-dichloromethane mobile phase, has been developed to separate propoxyphene and acetaminophen in less than 5 min. Quantitative recovery of both compounds from various pharmaceutical preparations was achieved, following a single dilution scheme. The method is stable, reproducible, and selective.
Ascah
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TL
Supelco, Inc., Bellefonte, PA 16823-0048.
Hunter
B T
BT
D000082:Acetaminophen / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D011431:Dextropropoxyphene / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet
D000082:Acetaminophen; D011431:Dextropropoxyphene