Synthesis and biological activity of some new pyrimidine and thienopyrimidine derivatives.
The readily available 4-mercapto-6-methyl-2-phenyl-5-acetylpyrimidine (1) was alkylated with a variety of activated halomethylene compounds to give the corresponding thieno [2,3-d] pyrimidine derivatives 3a-h via the intermediate alkylmercaptopyrimidine derivatives 2b-h. The biological activity of the new compounds was screened against several strains of bacteria.
el-Bahaie
S
S
Department of Chemistry, Faculty of Science, Zagazig University, ARE.
Kadry
A M
AM
Assy
M G
MG
Ibrahim
Y A
YA
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D011743:Pyrimidines