Effect of low-dose irradiation upon T cell subsets involved in the response of primed A/J mice to SaI cells.
A/Jax (A/J) mice primed to Sarcoma I (SaI) exhibit an augmented response in association with low-dose (0.15 Gy) irradiation. This phenomenon is best demonstrated in tumour neutralization (Winn assay) or cell transfer experiments utilizing mice depleted of thymus-derived (T) cells. It is particularly dependent upon the duration of priming and the growth characteristics of the tumour in the primary host. The importance of these two variables appears to relate to their influence upon the cell types responsible for the host response, and includes both an effector and a suppressor component. Radiation-induced inhibition of the suppressor component appears responsible for low-dose augmentation and results in injury to a T cell of the Lyt-1-2+ phenotype. In Winn assays employing equal numbers of immune spleen cells and SaI cells, the smallest tumours are associated with Lyt-1-positive (Lyt-1+2- and Lyt-1+2+) cells and exposure to 0.15 Gy markedly inhibits their anti-SaI activity. Thus, even though the effect is in the opposite direction, both the effector and suppressor components of the anti-SaI response in A/J mice are exceedingly radiosensitive.
Anderson
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Department of Pathology, University of New Mexico, School of Medicine, Albuquerque 87131.
Williams
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Tokuda
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D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007116:Immunization, Passive; D051379:Mice; D008805:Mice, Inbred A / Q000276:immunology; D012513:Sarcoma, Experimental / Q000276:immunology*; D013154:Spleen / Q000637:transplantation; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology / Q000528:radiation effects* / Q000637:transplantation