[Individual sensitivity of cilia. A simple in vitro test method].
A simple patient-related method is described that determines the effect of toxic substances on the ciliary activity of human nasal cilia cells. The method is suitable for investigating and numerically determining substance-specific toxicity and individual sensitivity even between patients of different states of health. This is illustrated by the example of two preservatives introduced in human medicine: chlorhexidine and merthiolate.
Wichelhaus
A
A
Univ.-Hals-Nasen-Ohrenklinik Heidelberg.
Enzmann
H
H
D002710:Chlorhexidine / Q000633:toxicity*; D002923:Cilia / Q000187:drug effects; D005035:Ethylmercury Compounds / Q000633:toxicity*; D006801:Humans; D009297:Nasal Mucosa / Q000187:drug effects*; D010592:Pharmaceutic Aids / Q000633:toxicity*; D011310:Preservatives, Pharmaceutical / Q000633:toxicity*; D013849:Thimerosal / Q000633:toxicity*
D005035:Ethylmercury Compounds; D010592:Pharmaceutic Aids; D011310:Preservatives, Pharmaceutical; D013849:Thimerosal; D002710:Chlorhexidine
Individuelle Empfindlichkeit der Cilien. Eine einfache in-vitro-Testmethode.