title: Effect of psychosocial stress on natural killer cell activity.
abstract: Previous studies have indicated that the degree of stress controllability, rather than stress itself, may be a factor in immunosuppression. In the present study lymphocytes were obtained from individuals living in agricultural settlements in the Jerusalem area who are under the medical supervision of family-oriented primary health care clinics. Peripheral blood lymphocytes (PBL) obtained from married, adult males classified either as "copers" or as "non-copers" were tested for their natural killer (NK) activity and for the expression of the Leu 7 and Leu 11 NK-associated antigens. Differences were noted in the NK activity of PBL obtained from individuals belonging to various ethnic origins. Among Moroccan Jews the NK activity of non-copers was significantly lower than that of copers. In contrast, the proportion of PBL carrying antigenic markers of NK cells (Leu 7 and Leu 11) was higher among copers than among non-copers. Thus, psychosocial stress may lead in non-copers to decreased NK activity paralleled by an increase in the proportion of either immature pre-NK cells or possibly other immunoregulatory cells.
authors.affiliation: Hubert H. Humphrey Center for Experimental Medicine and Cancer Research, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Schlesinger
authors.forename: Y
authors.initials: Y
authors.lastname: Yodfat
mesh_terms: D005190:Family; D006801:Humans; D007108:Immune Tolerance; D007557:Israel; D007694:Killer Cells, Natural / Q000145:classification / Q000502:physiology*; D008019:Life Style; D008297:Male; D012016:Reference Values; D012931:Social Environment; D012944:Social Support; D013312:Stress, Physiological / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology