Effects of procainamide and disopyramide on long chain acyl carnitine and long chain acyl CoA concentrations in the ischemic heart.
Though the efficacies of procainamide and disopyramide in treating arrhythmias are well established, their precise mechanisms of antiarrhythmic action remain unclear. Arrhythmias which occur during acute myocardial ischemia can be explained partly on a metabolic basis. The accumulation of intermediates subsequent to impaired beta-oxidation of free fatty acids has been suggested as a cause of serious arrhythmias. The purpose of this study was to investigate changes in free carnitine, long chain acyl carnitine and long chain acyl CoA concentrations in the ischemic canine heart following the administration of procainamide and disopyramide. The coronary artery was occluded for 40 min and myocardial samples were prepared from both nonischemic and ischemic areas. Procainamide and disopyramide prevented the accumulation of long chain acyl carnitine and long chain acyl CoA in the ischemic myocardium. The results showed that procainamide and disopyramide had beneficial effects on fatty acid metabolism. It was suggested that one of the antiarrhythmic mechanisms of these drugs might be the prevention of the accumulation of fatty acyl derivatives in the ischemic myocardium.
Kobayashi
A
A
Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.
Watanabe
H
H
Yamazaki
N
N
D000214:Acyl Coenzyme A / Q000378:metabolism*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D002331:Carnitine / Q000378:metabolism*; D003327:Coronary Disease / Q000188:drug therapy*; D004206:Disopyramide / Q000494:pharmacology* / Q000627:therapeutic use; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011342:Procainamide / Q000494:pharmacology* / Q000627:therapeutic use
D000214:Acyl Coenzyme A; D005230:Fatty Acids, Nonesterified; D004206:Disopyramide; D011342:Procainamide; D002331:Carnitine