Plasma 10-hydroxynortriptyline and therapeutic response in geriatric depression.
Geriatric inpatients with major depression received nortriptyline for 4 weeks. Plasma E-10-hydroxynortriptyline concentrations were correlated positively with residual Hamilton depression ratings and negatively with changes in ratings.
Young
R C
RC
Department of Psychiatry, New York Hospital-Cornell Medical Center, NY.
Alexopoulos
G S
GS
Shindledecker
R
R
Dhar
A K
AK
Kutt
H
H
D000368:Aged; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D009661:Nortriptyline / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use*; D013997:Time Factors
C013567:10-hydroxynortriptyline; D009661:Nortriptyline