Stizolobic acid, a competitive antagonist of the quisqualate-type receptor at the crayfish neuromuscular junction.
Stizolobic acid and stizolobinic acid are amino acids isolated from a plant, Stizolobium hassjoo. Both amino acids reduced responses to glutamate and quisqualate in a competitive manner at the crayfish neuromuscular junction, without affecting responses to GABA and acromelic acid. Excitatory junctional potentials were decreased in the presence of stizolobic or stizolobinic acid in a concentration dependent manner. Stizolobinic acid was about 5 times less potent than stizolobic acid.
Shinozaki
H
H
Tokyo Metropolitan Institute of Medical Science, Japan.
Ishida
M
M
D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology*; D000818:Animals; D003400:Astacoidea; D009469:Neuromuscular Junction / Q000187:drug effects*
D000600:Amino Acids, Dicarboxylic; C013261:stizolobic acid