title: High-dose lorazepam therapy for status epilepticus in a pediatric patient.
abstract: This report details the management of status epilepticus with high-dose lorazepam in a 14-year-old patient who was receiving oral clonazepam, ethosuximide, and phenobarbital for an intractable seizure disorder. Although respiratory depression is a frequently cited potential complication of therapy, it did not occur in this patient despite an extraordinarily high total dose of lorazepam, possibly because of tolerance associated with benzodiazepine-receptor down-regulation in this patient's chronic clonazepam therapy. Aggressive dosing of a benzodiazepine may be required for patients receiving chronic benzodiazepine therapy.
authors.affiliation: Department of Neurology, College of Medicine, University of Kentucky Medical Center, Lexington 40536.
authors.forename: H M
authors.initials: HM
authors.lastname: Reincke
authors.forename: R L
authors.initials: RL
authors.lastname: Gilmore
authors.forename: R J
authors.initials: RJ
authors.lastname: Kuhn
mesh_terms: D000293:Adolescent; D006801:Humans; D008140:Lorazepam / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D013226:Status Epilepticus / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D008140:Lorazepam