title: 5-Aminosalicylic acid in patients with ulcerative colitis in remission: plasma levels after administration of a new rectal enema.
abstract: Plasma levels of total 5-aminosalicylic acid (5-ASA) were determined after a single administration of 2 g and 4 g 5-ASA enemas to 6 patients with ulcerative colitis. The mean plasma levels and AUC values confirmed that the active substance is poorly absorbed by rectal route.
authors.affiliation: Istituto di Clinica Medica e Gastroenterologia, Policlinico S. Orsola, Bologna, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Gionchetti
authors.forename: A
authors.initials: A
authors.lastname: Belluzzi
authors.forename: M
authors.initials: M
authors.lastname: Campieri
authors.forename: F
authors.initials: F
authors.lastname: Torresan
authors.forename: G M
authors.initials: GM
authors.lastname: Tabanelli
authors.forename: C
authors.initials: C
authors.lastname: Brignola
authors.forename: M
authors.initials: M
authors.lastname: Miglioli
authors.forename: L
authors.initials: L
authors.lastname: Barbara
mesh_terms: D000328:Adult; D000636:Aminosalicylic Acids / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000378:metabolism*; D004733:Enema; D005260:Female; D006801:Humans; D008297:Male; D019804:Mesalamine; D008875:Middle Aged
chemical_list: D000636:Aminosalicylic Acids; D019804:Mesalamine