Assignment of the T-cell differentiation gene MAL to human chromosome 2, region cen----q13.
A cDNA clone has recently been isolated that encodes a protein expressed only in the intermediate and late stages of T-cell differentiation, termed MAL. The polypeptide deduced from the MAL cDNA sequence contains four potential transmembrane domains. We have used a panel of 28 human X rodent hybrid cell lines to assign the MAL gene to the proximal long arm of human chromosome 2, region cen----q13. The significance of the MAL map position and its relationship with other genes on chromosome 2 are discussed.
Alonso
M A
MA
Department of Human Genetics, Yale University School of Medicine, New Haven, CT 06510.
Barton
D E
DE
Francke
U
U
D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D006801:Humans; D006822:Hybrid Cells; D008565:Membrane Proteins / Q000235:genetics
D000945:Antigens, Differentiation, T-Lymphocyte; D008565:Membrane Proteins