[Modification of the regulatory effects of thymocytes on hematopoiesis in irradiated mice as affected by heterologous immunoglobulin G and low-dose ionizing radiation].
The administration of heterologous immunoglobulin G (IgG) and/or exposure of mouse thymocyte donors to 1 and 2 Gy radiation were shown to change the regulatory effects of thymus lymphocytes on the recovery of haemopoiesis in syngeneic recipients irradiated with a median lethal dose of 6 Gy. Thymocytes of exposed (2 Gy) donors produced a stimulatory effect on the restoration of the myelokaryocytes number and increased the number of endogenous splenic colonies and bone marrow CFUs in animals exposed to a median lethal dose, whereas the administration of IgG to thymocyte donors given 2 Gy eliminated the stimulatory effect of thymocytes on the number of myelokaryocytes, and the amount of CFUs in irradiated recipients decreased.
Lebedev
V G
VG
Moroz
B B
BB
Gutsenko
K K
KK
Ivanov
A A
AA
D000818:Animals; D000910:Antibodies, Heterophile / Q000008:administration & dosage*; D006410:Hematopoiesis; D006736:Horses / Q000276:immunology; D007074:Immunoglobulin G / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D013601:T-Lymphocytes / Q000502:physiology*
D000910:Antibodies, Heterophile; D007074:Immunoglobulin G
Modifikatsiia reguliatornykh éffektov timotsitov na gemopoéz obluchennykh mysheĭ pod vliianiem geterologichnogo immunoglobulina G i ioniziruiushchego izlucheniia v maloĭ doze.