title: Characterization of a murine model for human bismuth encephalopathy.
abstract: An epidemic of bismuth (Bi)-related neurotoxicity in France remains poorly understood, partly because no satisfactory animal model exists. We have now characterized such a model. Single or multiple intraperitoneal injections of Bi subnitrate into female mice produced neurologic signs (myoclonus, ataxia, tremors, convulsions) and blood (1.2 micrograms/g) and brain (8.4 micrograms/g) Bi levels like those in human cases. Hydrocephalus and axonal swellings in spinal cord were the major neuropathologic lesions.
authors.affiliation: Procter and Gamble Company, Cincinnati, Ohio 45247.
authors.forename: J F
authors.initials: JF
authors.lastname: Ross
authors.forename: Z
authors.initials: Z
authors.lastname: Sahenk
authors.forename: C
authors.initials: C
authors.lastname: Hyser
authors.forename: J R
authors.initials: JR
authors.lastname: Mendell
authors.forename: C L
authors.initials: CL
authors.lastname: Alden
mesh_terms: D000818:Animals; D001729:Bismuth / Q000009:adverse effects / Q000633:toxicity*; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D009498:Neurotoxins / Q000494:pharmacology*; D013118:Spinal Cord Diseases / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology
chemical_list: D009498:Neurotoxins; D001729:Bismuth