Nerve growth factor induces rapid redistribution of F-actin in PC12 cells.
Nerve growth factor (NGF) induces the redistribution of F-actin in rat pheochromocytoma PC12 cells within 2-10 min, whereas epidermal growth factor (EGF) has no effect on microfilament organization. This redistribution of F-actin in PC12 cells is not protein synthesis dependent, but can be blocked by methyltransferase inhibitors.
Paves
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H
Laboratory of Molecular Genetics, Institute of Chemical Physics and Biophysics, Estonian Academy of Sciences, USSR.
Neuman
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T
Metsis
M
M
Saarma
M
M
D000199:Actins / Q000378:metabolism*; D000310:Adrenal Gland Neoplasms / Q000378:metabolism*; D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005456:Fluorescent Dyes; D007700:Kinetics; D008780:Methyltransferases / Q000037:antagonists & inhibitors; D009414:Nerve Growth Factors / Q000494:pharmacology*; D010590:Phalloidine; D010673:Pheochromocytoma / Q000378:metabolism*; D051381:Rats; D012235:Rhodamines; D014407:Tumor Cells, Cultured
D000199:Actins; D005456:Fluorescent Dyes; D009414:Nerve Growth Factors; D012235:Rhodamines; D010590:Phalloidine; D004815:Epidermal Growth Factor; D003513:Cycloheximide; D008780:Methyltransferases