Drug/polymer matrix swelling and dissolution.
The swelling and dissolution behavior of pharmaceutical systems containing a drug and a polymer can be analyzed by a mathematical model which predicts the drug released and the gel layer thickness as a function of time. It is possible to approximate the values of several of the physicochemical parameters of this model in order to obtain an order-of-magnitude analysis of the tablet dissolution process. Selected experimental results of tablet dissolution and drug release are analyzed and conclusions are made about the importance of the drug and polymer content and solubility in the release behavior.
Harland
R S
RS
School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907.
Gazzaniga
A
A
Sangalli
M E
ME
Colombo
P
P
Peppas
N A
NA
D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D003692:Delayed-Action Preparations; D004058:Diffusion; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011108:Polymers / Q000032:analysis*; D011145:Polyvinyls; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D011108:Polymers; D011145:Polyvinyls; D013607:Tablets; C013215:polyvinyl acetate