Changes in receptor status after treatment with tamoxifen in endometrial cancer.
Estrogen (ER) and progesterone receptor (PgR) status was determined in 41 women with operable endometrial cancer before and after administration of tamoxifen (TAM). The first sample was obtained by hysteroscopy to ensure a precise biopsy of neoplastic tissue; the second was done on the surgical specimen. PgR content was significantly increased after TAM treatment and this data was compared with the degree of tumor differentiation.
Oriana
S
S
Institute of Statistics and Biometry, Università degli Studi, Milano, Italy.
Raspagliesi
F
F
Duca
P G
PG
Coradini
D
D
Di Re
E M
EM
Ragazzi
D
D
Grillo
T
T
Luciani
L
L
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy* / Q000473:pathology; D011960:Receptors, Estrogen / Q000187:drug effects*; D011980:Receptors, Progesterone / Q000187:drug effects*; D013629:Tamoxifen / Q000627:therapeutic use*; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014599:Uterus / Q000473:pathology
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D013629:Tamoxifen