IgA glomerulonephritis in Wiskott-Aldrich syndrome.
Renal morphology was evaluated in 2 siblings with Wiskott-Aldrich syndrome (WAS) aged 12 and 4 years. They gave a typical history of recurrent episodes of respiratory infection and presented with microhematuria of glomerular origin and proteinuria. The study disclosed a membranoproliferative glomerulonephritis with IgA mesangial deposition in the elder child, while immunofluorescence was negative in the younger. The data indicate that (1) a specific nephropathy does not exist in WAS and (2) the IgA nephropathy is the result of recurrent infections and of related formation of IgA immune complexes scarcely removed by a deficient reticuloendothelial system. This view is consistent with presenting features in WAS (microhematuria, episodes of macrohematuria, proteinuria, Henoch-Schönlein syndrome) and with the fact that it takes years to develop as indicated by the negativity of immunofluorescence in the younger patient.
DeSanto
N G
NG
Department of Pediatrics, University of Naples, Italy.
Sessa
A
A
Capodicasa
G
G
Meroni
M
M
Capasso
G
G
Esposito
L
L
Ferrara
M
M
Torri Tarelli
L
L
Annunziata
S
S
Giordano
C
C
D002648:Child; D002675:Child, Preschool; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D014923:Wiskott-Aldrich Syndrome / Q000150:complications* / Q000235:genetics / Q000473:pathology