Structure of the mouse serum amyloid P component gene.
A genomic DNA clone corresponding to the mouse serum amyloid P component (SAP) has been isolated and characterized for the first time. The numbers of exons, the relative sites of intron/exon junctions, and the size of the coding region for mature SAP protein are all in complete agreement with those of the human SAP gene. In the 5'-flanking region of the mouse SAP gene, there is a small DNA segment (43-base pairs) which is highly homologous with the corresponding region of the human SAP gene. However, most parts of the 5'-flanking regions are not conserved between the mouse and human SAP genes, and several phorbol ester-responsive element-like sequences are present only in the mouse SAP gene.
Nishiguchi
S
S
Department of Biochemistry, Kumamoto University Medical School, Japan.
Maeda
S
S
Araki
S
S
Shimada
K
K
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015342:DNA Probes; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D000683:Serum Amyloid P-Component / Q000235:genetics*
D015342:DNA Probes; D000683:Serum Amyloid P-Component; C025630:CAGCTG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific