Facilitating effect of oxiracetam and piracetam on acquisition of discrete two-way shuttle avoidance in normal mice.
Effects of oxiracetam and piracetam on acquisition of the discrete two-way shuttle avoidance response were investigated in normal mice of the dd strain. When oxiracetam or piracetam was administered only once immediately before the training session, the mice showed a greater number of avoidance responses in comparison with the saline-treated control mice, with the maximum effect at 30 mg/kg of oxiracetam and 100 mg/kg of piracetam. These results suggest that oxiracetam and piracetam facilitate the avoidance acquisition in normal mice.
Kuribara
H
H
Division for Behavior Analysis, Gunma University School of Medicine, Maebashi, Japan.
Tadokoro
S
S
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D010889:Piracetam / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*
D011759:Pyrrolidines; D011760:Pyrrolidinones; C040619:oxiracetam; D010889:Piracetam