Acyl derivatives of 1,5-benzodiazepines. III. Acyl derivatives of ethyl ester of 4-methyl-1H-tetrahydro-1,5-benzodiazepine-2-carboxylic acid.
Two series of derivatives of ethyl ester of 4-methyl-1H-tetrahydro-1,5-benzodiazepine-2-carboxylic acid (1) have been synthesized. The acetyl derivative (2) of ester 1 in preliminary pharmacological screening showed analgesic activity in the "writhing" test and the benzoyl derivative (5) exhibited antianxiety properties in the four plate test, while N,N-disubstituted aminoacetyl derivatives of 1 showed analgesic and anticonvulsant activity (10).
Nawojski
A
A
Department of Technology of Drugs, Medical Academy, Wrocław, Poland.
Nawrocka
W
W
Liszkiewicz
H
H
Wilimowski
M
M
Barczyńska
J
J
Kedzierska
L
L
Wojewódzki
W
W
Rutkowska
M
M
Duś
E
E
Szelag
A
A
D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors; D012702:Serotonin Antagonists; D013239:Stereotyped Behavior / Q000187:drug effects
D000700:Analgesics; D000927:Anticonvulsants; D012702:Serotonin Antagonists; D001569:Benzodiazepines; D012110:Reserpine; D001058:Apomorphine