title: Elevated plasma hydroxyproline. A possible risk factor associated with connective tissue injuries during overuse.
abstract: Basal plasma hydroxyproline was measured in 104 male Navy Seal candidates 1 week into their intense physical training program, which lasted 7 weeks, and correlated to the incidence of connective tissue injuries incurred later in the training program. Eleven subjects (10.6%) were diagnosed as having connective tissue injuries. Those subjects with connective tissue injuries had a significantly higher (P less than 0.05) mean plasma hydroxyproline value (4.02 micrograms/ml) than subjects without injury (3.10 micrograms/ml). The majority of graduates (75%) had plasma hydroxyproline values less than 3.3 micrograms/ml. These graduates represented the strongest and most enduring injury-free subjects. Of the subject pool who incurred connective tissue injuries, only 27% had plasma hydroxyproline values less than 3.3 micrograms/ml. The majority of the injured subjects (73%) had plasma hydroxyproline values greater than or equal to 3.3 micrograms/ml. In conclusion, there is a relationship between initial training basal plasma hydroxyproline levels and connective tissue injuries later incurred in an intense physical training program. These data suggest that elevated plasma hydroxyproline levels may represent a risk factor associated with connective tissue injuries.
authors.affiliation: Department of Kinesiology, University of California, Los Angeles.
authors.forename: M J
authors.initials: MJ
authors.lastname: Murguia
authors.forename: A
authors.initials: A
authors.lastname: Vailas
authors.forename: B
authors.initials: B
authors.lastname: Mandelbaum
authors.forename: J
authors.initials: J
authors.lastname: Norton
authors.forename: J
authors.initials: J
authors.lastname: Hodgdon
authors.forename: H
authors.initials: H
authors.lastname: Goforth
authors.forename: M
authors.initials: M
authors.lastname: Riedy
mesh_terms: D000293:Adolescent; D000328:Adult; D001265:Athletic Injuries / Q000209:etiology*; D003238:Connective Tissue; D006801:Humans; D006909:Hydroxyproline / Q000097:blood*; D008297:Male; D009326:Naval Medicine; D010806:Physical Education and Training; D012307:Risk Factors
chemical_list: D006909:Hydroxyproline