T cell receptor alpha mRNA transcription in T-lymphoblastic transformation of chronic myelocytic leukemia.
Analysis at the DNA and RNA level revealed a mature genetic marker profile in a case of T type blast crisis of chronic myelocytic leukemia. T cell receptor beta chain gene rearrangement as well as T cell receptor alpha mRNA transcription was demonstrated in blasts of the malignant clone. Corresponding findings were obtained from immunological phenotyping. Blasts were found to be CD7+, CD1+, CD3+, CD4+, CD8+, and TdT- and classified as common/mature thymocytes. The presence of the breakpoint cluster region gene on chromosome 22 excluded the possibility of a second neoplastic process.
Valent
P
P
Department of Medicine, University of Vienna, Austria.
Bartram
C R
CR
Radaszkiewicz
T
T
Hinterberger
W
W
Lechner
K
K
Bettelheim
P
P
D000328:Adult; D000954:Antigens, Surface / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000032:analysis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D008213:Lymphocyte Activation; D008297:Male; D010641:Phenotype; D012333:RNA, Messenger / Q000032:analysis; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology*; D014158:Transcription, Genetic
D000954:Antigens, Surface; D012333:RNA, Messenger; D011948:Receptors, Antigen, T-Cell