HLA-associated susceptibility to AIDS: HLA B35 is a major risk factor for Italian HIV-infected intravenous drug addicts.
Thirty-one AIDS patients were typed for HLA A, B, C, and DR antigens. We confirmed that frequency of B35 is significantly higher in patients than in controls. No significant frequency differences in other HLA antigens were found. The analysis of HLA distribution in AIDS patients by risk categories suggests that B35 is a major risk factor, primarily mainly for patients belonging to the category of intravenous (IV) drug addicts.
Scorza Smeraldi
R
R
Institute of Internal Medicine, Infectious Diseases and Immunopathology, University of Milan, Italy.
Fabio
G
G
Lazzarin
A
A
Eisera
N
N
Uberti Foppa
C
C
Moroni
M
M
Zanussi
C
C
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D015797:HLA-B35 Antigen; D006801:Humans; D007558:Italy; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000150:complications
D006680:HLA Antigens; D015797:HLA-B35 Antigen