[Kinetics of tissue sodium metabolism and the vascular reactivity to vasopressor agents in healthy persons with different degree of risk of developing arterial hypertension].
A study of 69 normal males, aged 20 to 54 years and running increased risks of arterial hypertension, demonstrated vascular hyper-reactivity to humoral vasoconstrictors, weakened gustatory sensitivity to salt and a tendency to sodium deposition in tissues, which were induced by increased salt uptake. Their plasma aldosterone levels were increased in the presence of salt loading and showed correlation to the degree of tissue sodium metabolism slow-down. No intergroup variation was demonstrated in diurnal sodium excretion, total metabolizing sodium in the body and natriuretic response to acute salt loads.
Merzhievskaia
V M
VM
Shterental'
I Sh
ISh
D000328:Adult; D000804:Angiotensin II / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology*; D011379:Prognosis; D012307:Risk Factors; D012867:Skin / Q000098:blood supply*; D012965:Sodium Chloride / Q000378:metabolism* / Q000493:pharmacokinetics
D000804:Angiotensin II; D012965:Sodium Chloride; D009638:Norepinephrine
Kinetika tkanevogo obmena natriia i reaktivnost' sosudov k vazopressornym veshchestvam u zdorovykh lits s razlichnoĭ stepen'iu riska razvitiia arterial'noĭ gipertonii.