Characterization of a murine model for human bismuth encephalopathy.
An epidemic of bismuth (Bi)-related neurotoxicity in France remains poorly understood, partly because no satisfactory animal model exists. We have now characterized such a model. Single or multiple intraperitoneal injections of Bi subnitrate into female mice produced neurologic signs (myoclonus, ataxia, tremors, convulsions) and blood (1.2 micrograms/g) and brain (8.4 micrograms/g) Bi levels like those in human cases. Hydrocephalus and axonal swellings in spinal cord were the major neuropathologic lesions.
Ross
J F
JF
Procter and Gamble Company, Cincinnati, Ohio 45247.
Sahenk
Z
Z
Hyser
C
C
Mendell
J R
JR
Alden
C L
CL
D000818:Animals; D001729:Bismuth / Q000009:adverse effects / Q000633:toxicity*; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D009498:Neurotoxins / Q000494:pharmacology*; D013118:Spinal Cord Diseases / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology
D009498:Neurotoxins; D001729:Bismuth