[5-Chlorodeoxyuridine, more effectively than 5-bromodeoxyuridine, induces the formation of specific dicentric chromosomes in cells with micronuclei].
5-chlorodeoxyuridine (5-ChldU) and 5-bromodeoxyuridine (5-BrdU) were tested in respect of the formation of specific dicentric chromosomes in cells with micronuclei. It is shown that the frequency of dicentrics is higher when 5-ChldU is used. On the ground of results of this study and of the previous data it is concluded that the activity of halogenated deoxyuridines is falling with molecular weight increasing.
Stobetskiĭ
V I
VI
Mironova
L L
LL
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002460:Cell Line; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D003703:Demecolcine / Q000494:pharmacology; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000494:pharmacology; D015162:Micronucleus Tests; D008970:Molecular Weight
C012244:5-chloro-2'-deoxyuridine; D001973:Bromodeoxyuridine; D003857:Deoxyuridine; D003703:Demecolcine
5-Khlordezoksiuridin bolee éffektivno chem 5-bromdezoksiuridin, indutsiruet obrazovanie spetsificheskikh ditsentricheskikh khromosom v kletkakh s mikroiadrami.