A technique for simultaneously comparing the release of noradrenaline evoked by field stimulation and by propagated nerve impulses in rabbit ear arteries.
1. A technique has been described which utilized radiotracer methods to measure the release of transmitter noradrenaline, simultaneously, from segments of rabbit ear artery subjected to field stimulation and propagated nerve impulses. 2. The release of radioactivity from arteries labelled with 3H-noradrenaline was much greater in the segment subjected to field stimulation than in the segment stimulated by propagated nerve impulses. 3. The release of radioactivity from segments invaded by nerve impulses decreased progressively with increases in frequency through the range of 10-50 Hz, using 150 pulses at 10, 15, 20, 30 and 50 Hz. However, the release remained constant in the field stimulated segments throughout the frequency range used.
Rand
M J
MJ
Department of Pharmacology, University of Melbourne, Victoria, Australia.
Story
D F
DF
Sutton
I
I
D000818:Animals; D001158:Arteries / Q000294:innervation; D004423:Ear / Q000098:blood supply* / Q000294:innervation; D004558:Electric Stimulation; D005260:Female; D008297:Male; D009431:Neural Conduction; D009638:Norepinephrine / Q000097:blood*; D011817:Rabbits; D013779:Tetrodotoxin / Q000494:pharmacology
D013779:Tetrodotoxin; D009638:Norepinephrine