Rhabdomyolysis, oedema and arterial hypertension: different syndromes related to topical use of 9-alpha-fluoroprednisolone.
Over a one year period we detected five cases of iatrogenic mineralocorticoidism secondary to topical application of creams containing 9-alpha-fluoro-prednisolone. Although the same product was involved in all cases, the clinical features differed and included two cases of myopathy and hypokalemic rhabdomyolysis, one of oedema and two of arterial hypertension. Discontinuation of treatment and administration of potassium supplements produced a rapid recovery and all patients remain well six months later.
Lauzurica
R
R
Nephrology Department, Hospital de Badalona Germans Trias I Pujol, Spain.
Bonal
J
J
Bonet
J
J
Romero
R
R
Teixido
J
J
Serra
A
A
Caralps
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D004487:Edema / Q000097:blood / Q000139:chemically induced*; D005260:Female; D005477:Fluprednisolone / Q000009:adverse effects* / Q000031:analogs & derivatives; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D007008:Hypokalemia / Q000097:blood / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000097:blood / Q000139:chemically induced*
C010958:9-fluoroprednisolone; D005477:Fluprednisolone