[Chromosome of transplantable lung adenocarcinoma cell line (LA-795)].
The chromosome patterns of lung adenocarcinoma cell line LA-795 were studied with G and C banding techniques at passages 60 and 100. The model chromosome numbers were 69, 68, 67 and 66. G banding of 46 cells of the four clones (69, 68, 67 and 66) were analysed. The chromosome patterns of this cell line were hypotetraploid male cells which were similar to those transplanted in mice. The 69 model chromosome comprises two types, 69I and 69II. According to the karyotype analysis, the evolution process of clone from 69 to 68, 67 and 66 was recognized by the karyotype of various clones. The lose of chromosome No. 4 and No. 14 in various model chromosome cell lines may be a non-random chromosome aberration of mouse tumor cells.
Ling
L H
LH
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing.
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D051379:Mice; D009368:Neoplasm Transplantation