title: Excretion of mefloquine in human breast milk.
abstract: Concentrations of mefloquine in plasma and breast milk were measured in 2 women following the administration of one Lariam tablet (250 mg mefloquine). The milk-to-plasma ratio of mefloquine based on the area under the plasma and milk concentration curves was 0.13 and 0.16. After a maternal mefloquine dose of 3.73 mg/kg and assuming a daily milk ingestion of 1 litre over a week, the maximum amount of drug ingested by an infant would be 0.14 mg/kg. During lactation the plasma clearance and apparent volume of distribution of mefloquine were about 50% less than the same parameters calculated after lactation had ceased.
authors.affiliation: Army Malaria Research Unit, Milpo, Ingleburn, Australia.
authors.forename: M D
authors.initials: MD
authors.lastname: Edstein
authors.forename: J R
authors.initials: JR
authors.lastname: Veenendaal
authors.forename: R
authors.initials: R
authors.lastname: Hyslop
mesh_terms: D000328:Adult; D005260:Female; D006207:Half-Life; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007774:Lactation / Q000502:physiology; D015767:Mefloquine; D008895:Milk, Human / Q000032:analysis*; D011247:Pregnancy; D011804:Quinolines / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood
chemical_list: D011804:Quinolines; D015767:Mefloquine