Cell-mediated immune response in patients with type IIa, type IIb and type IV primary hyperlipoproteinaemia.
Plasma lipoproteins inhibit immune function. Polymorphonuclear cell (PMN) and monocyte activities, and pokeweed mitogen (PWM)-driven B cell differentiation in patients with type IIa, type IIb and type IV primary hyperlipoproteinaemia were evaluated. Evidence is provided for a selective impairment of these functional capacities in type IIa and type IIb hyperlipoproteinaemic patients, while immune responsiveness is unaffected in type IV primary hyperlipoproteinaemia. The data suggest a specific immune dysfunction in patients with type IIa and type IIb primary hyperlipoproteinaemia.
Antonaci
S
S
Fisiopatologia Medica, University of Bari Medical School, Italy.
Jirillo
E
E
Garofalo
A R
AR
Polignano
A
A
Resta
F
F
Pugliese
P
P
Capurso
A
A
Bonomo
L
L
D000328:Adult; D001402:B-Lymphocytes / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000276:immunology* / Q000473:pathology; D006953:Hyperlipoproteinemia Type IV / Q000276:immunology* / Q000473:pathology; D007111:Immunity, Cellular; D007963:Leukocytes, Mononuclear / Q000502:physiology; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000473:pathology
D011043:Pokeweed Mitogens