title: Detection of human B-lymphotropic virus (human herpesvirus 6) sequences in B cell lymphoma tissues of three patients.
abstract: A survey for HBLV (human B-lymphotropic herpesvirus or human herpesvirus 6) sequences by Southern blot analyses was performed on DNA obtained from a variety of pathologically defined tissues, including a number of lymphomas, leukemias, and tissues from other hematologic disorders. Of the over 50 specimens studied, viral sequences were detected in three lymphomas of B cell derivation: an Epstein-Barr virus-positive African Burkitt's lymphoma, a follicular large cell lymphoma (nodular histocytic lymphoma), and two Epstein-Barr virus-negative tumors from a patient with Sjogren's syndrome. These results are the first indication of HBLV sequences associated with B cell tumors in a limited number of cases and raise the possibility that the virus might be involved in the genesis of some B cell tumors.
authors.affiliation: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205.
authors.forename: S F
authors.initials: SF
authors.lastname: Josephs
authors.forename: A
authors.initials: A
authors.lastname: Buchbinder
authors.forename: H Z
authors.initials: HZ
authors.lastname: Streicher
authors.forename: D V
authors.initials: DV
authors.lastname: Ablashi
authors.forename: S Z
authors.initials: SZ
authors.lastname: Salahuddin
authors.forename: H G
authors.initials: HG
authors.lastname: Guo
authors.forename: F
authors.initials: F
authors.lastname: Wong-Staal
authors.forename: J
authors.initials: J
authors.lastname: Cossman
authors.forename: M
authors.initials: M
authors.lastname: Raffeld
authors.forename: J
authors.initials: J
authors.lastname: Sundeen
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000032:analysis* / Q000382:microbiology; D002051:Burkitt Lymphoma / Q000032:analysis / Q000382:microbiology; D002675:Child, Preschool; D004279:DNA, Viral / Q000302:isolation & purification*; D005260:Female; D006564:Herpesviridae / Q000235:genetics*; D006801:Humans; D008223:Lymphoma / Q000032:analysis* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization
chemical_list: D004279:DNA, Viral