title: A comparison of follicular fluid levels of insulin-like growth factor-1 in normal dominant and cohort follicles, polycystic and multicystic ovaries.
abstract: Fourteen ovulatory patients undergoing diagnostic laparoscopy had at least two samples of clear follicular fluid (FF) collected in the late follicular phase. The cohort concentrations of Insulin-like Growth Factor-1 (IGF1) were significantly correlated with serum IGF1 and dominant follicles contained significantly higher concentrations of IGF1 and oestradiol (E2) than their cohorts. After the LH surge, a further significant increase in dominant FF-IGF1 occurred. FF-(log)E2 was significantly correlated with both FF-IGF1 and FF volume. Nine women with the polycystic ovary syndrome (PCOS) and one patient with multicystic ovaries (MCO) associated with weight-loss related amenorrhoea also had follicular aspiration performed. The mean (SD) FF-IGF1 in the PCOS group, 0.42 (0.15) U/ml, was not significantly different from that of the cohorts in the control group, 0.39 (0.13) U/ml. The patient with MCO had both serum and FF-IGF1 concentrations less than 10th centile. These results support the hypothesis that IGF1 has a paracrine (and possibly endocrine) role in the regulation of ovarian function in the human female.
authors.affiliation: Department of Gynaecology, Charing Cross Hospital, London, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Eden
authors.forename: J
authors.initials: J
authors.lastname: Jones
authors.forename: G D
authors.initials: GD
authors.lastname: Carter
authors.forename: J
authors.initials: J
authors.lastname: Alaghband-Zadeh
mesh_terms: D000328:Adult; D001826:Body Fluids / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism; D005260:Female; D005497:Follicular Cyst / Q000378:metabolism* / Q000503:physiopathology; D005498:Follicular Phase; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D006080:Ovarian Follicle / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000378:metabolism* / Q000503:physiopathology; D013002:Somatomedins / Q000378:metabolism*
chemical_list: D013002:Somatomedins; D004958:Estradiol; D007334:Insulin-Like Growth Factor I