Multicentric reticulohistiocytosis: a case with enhanced interleukin-1, prostaglandin E2 and interleukin-2 secretion.
We describe a 47-year-old woman with multicentric reticulohistiocytosis. While the disease was in remission without therapy, interleukin-1 and prostaglandin E2 secretions by adherent cells was increased as well as interleukin-2 secretion by peripheral mononuclear cells. This suggests that macrophages play an essential role in the pathogenesis of this disease.
Zagala
A
A
Department of Rheumatology, Chu de Grenoble, France.
Guyot
A
A
Bensa
J C
JC
Phelip
X
X
D001168:Arthritis / Q000150:complications; D015232:Dinoprostone; D005260:Female; D006644:Histiocytes / Q000378:metabolism; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D050356:Lipid Metabolism; D008206:Lymphatic Diseases / Q000276:immunology / Q000378:metabolism*; D008262:Macrophage Activation; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism; D011458:Prostaglandins E / Q000378:metabolism*; D012871:Skin Diseases / Q000378:metabolism
D007375:Interleukin-1; D007376:Interleukin-2; D011458:Prostaglandins E; D015232:Dinoprostone