Short-term effects of i.v. injected murine 99MTc-F(ab')2 fragments of an anti-melanoma antibody (HMW-MAA 225.28 S) on haemato-immunological parameters in patients with melanoma.
To evaluate alterations induced by injected murine radiolabelled F(ab')2 fragments of the anti HMW-MAA MoAb 225.28S on the principal haemato-immunological parameters, 32 patients with advanced malignant melanoma were studied. No statistically significant change was found after MoAb administration, but monocytes (3 h after injection) and granular eosinophils (24 h after) were reduced and circulating immune complexes increased (3 h after). No toxic effect or adverse reaction was observed. Therefore, the controlled administration of purified MoAb fragments for diagnostic purposes seems to involve only a very low risk of immediate adverse reactions.
Castello
G
G
Dept. of Haematology and Immunology, National Cancer Institute, Napoli, Italy.
Mansi
L
L
Leonardi
E
E
Lastoria
S
S
Melillo
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000032:analysis; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor / Q000276:immunology*; D001772:Blood Cell Count; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage*; D007275:Injections, Intravenous; D008297:Male; D008545:Melanoma / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D058950:Melanoma-Specific Antigens; D051379:Mice; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000276:immunology*; D013667:Technetium
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D007140:Immunoglobulin Fab Fragments; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D013667:Technetium