One factor recognizes the liver-specific enhancers in alpha 1-antitrypsin and transthyretin genes.
Four different regulatory sites required for transcriptional stimulation by the enhancers of two unrelated liver-specific genes alpha 1-antitrypsin and transthyretin appear to bind the same nuclear protein that is found mainly in the liver. Such proteins may provide a basis for a coordinated, hepatocyte-specific control of gene transcription.
Grayson
D R
DR
Rockefeller University, New York, NY 10021.
Costa
R H
RH
Xanthopoulos
K G
KG
Darnell
J E
JE
D000818:Animals; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D005796:Genes; D005809:Genes, Regulator; D008099:Liver / Q000378:metabolism*; D051379:Mice; D009154:Mutation; D009687:Nuclear Proteins / Q000502:physiology*; D011228:Prealbumin / Q000235:genetics*; D014158:Transcription, Genetic; D000515:alpha 1-Antitrypsin / Q000235:genetics*
D009687:Nuclear Proteins; D011228:Prealbumin; D000515:alpha 1-Antitrypsin