title: Production of B cell stimulatory factor-2/interleukin-6 activity by human endothelial cells.
abstract: The effect of culture supernatants of endothelial cell (EC) lines on the immunoglobulin-M(IgM) synthesis by human B cell line, SKW6-CL4 cells, was investigated. Supernatants of human EC stimulated IgM synthesis, as high as 6-fold, but supernatants of bovine EC did not. This enhancing activity was completely blocked by addition of anti-human B cell stimulatory factor-2/interleukin-6 (BSF-2/IL-6) antibody. These data suggest that human EC might participate in the human antibody production system by producing soluble factor, BSF-2/IL-6.
authors.affiliation: First Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Norioka
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: M
authors.initials: M
authors.lastname: Harigai
authors.forename: A
authors.initials: A
authors.lastname: Kitani
authors.forename: T
authors.initials: T
authors.lastname: Hirose
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Kawakami
authors.forename: H
authors.initials: H
authors.lastname: Tabata
authors.forename: M
authors.initials: M
authors.lastname: Kawagoe
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D000906:Antibodies; D002460:Cell Line; D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D015850:Interleukin-6; D007378:Interleukins / Q000096:biosynthesis*; D011817:Rabbits
chemical_list: D000906:Antibodies; D007075:Immunoglobulin M; D015850:Interleukin-6; D007378:Interleukins