Effect of prolactin on amino acid catabolism in the female rat.
Rats treated with prolactin showed a rise in food consumption and an increased deposition of both lean tissue and fat. Rats pair-fed with untreated controls showed an increase in lean tissue, and a reduction in the activities of two key enzymes that control amino acid oxidation and urea synthesis in the liver. This adjustment in protein metabolism may regulate the amino acid supply in relation to the needs for milk protein synthesis during lactation.
Naismith
D J
DJ
Department of Food and Nutritional Sciences, King's College, London, UK.
Walker
S P
SP
D000273:Adipose Tissue / Q000378:metabolism; D000410:Alanine Transaminase / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001124:Argininosuccinate Synthase / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D002149:Energy Intake / Q000187:drug effects; D005260:Female; D007774:Lactation / Q000187:drug effects; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008894:Milk Proteins / Q000096:biosynthesis; D011247:Pregnancy; D011388:Prolactin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014508:Urea / Q000096:biosynthesis
D000596:Amino Acids; D008894:Milk Proteins; D014508:Urea; D011388:Prolactin; D000410:Alanine Transaminase; D001124:Argininosuccinate Synthase