title: Silent hepatitis-B immunization in laboratory technicians.
abstract: The present investigation was initiated to assess the demand for vaccination against hepatitis-B in a department of clinical chemistry. One hundred and twenty-eight employees enrolled for the test programme consisting primarily of screening for hepatitis-B antigen (HBsAg) and antibody to hepatitis-B surface antigen (anti-HBs). Surprisingly it was found, that 8 persons out of 58 who had also participated in a screening survey in 1978 had developed anti-HBs. These persons, who had no history of hepatitis, were also positive for antibodies towards the core antigen of hepatitis-B (anti-HBc). A seroconversion rate of 1,53/100/year for this material was calculated. Six persons who had contracted hepatitis-B during an epidemic 14 years previously, presented with very weak anti-HBs reactivity, but were positive for anti-HBc indicating, that anti-HBc was the more stable indicator of past HBV infection. The cost-effectiveness of vaccination against HBV seems disputable compared with other protective measures. The high incidence of silent seroconversion indicates a chronic exposure to virus among the laboratory personnel. Therefore, safety precautions against virus exposure are highly recommended.
authors.affiliation: Department of Clinical Chemistry, Aarhus Kommunehospital, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Ingerslev
authors.forename: E
authors.initials: E
authors.lastname: Mortensen
authors.forename: K
authors.initials: K
authors.lastname: Rasmussen
authors.forename: J
authors.initials: J
authors.lastname: Jørgensen
authors.forename: P
authors.initials: P
authors.lastname: Skinhøj
mesh_terms: D000328:Adult; D006509:Hepatitis B / Q000517:prevention & control; D006511:Hepatitis B Antigens / Q000032:analysis*; D006512:Hepatitis B Core Antigens / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D007116:Immunization, Passive; D007755:Laboratories, Hospital; D009787:Occupational Medicine; D000078329:Workforce
chemical_list: D006511:Hepatitis B Antigens; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens