title: Treatment of coronary heart disease by diet and exercise: fasting and diurnal lipoproteins.
abstract: The effects of a combined exercise and low-fat dietary regimen were studied in 11 patients with angiographically documented coronary heart disease (cholesterol 233 mg/dl, triglycerides 158 mg/dl) and 13 comparable patients (cholesterol 224 mg/dl, triglycerides 174 mg/dl) on usual care. During one year, fasting serum lipoproteins were lowered to "ideal" levels in the intervention group (cholesterol 191 mg/dl, triglycerides 100 mg/dl, LDL-cholesterol 121 mg/dl). There was no change of triglycerides and cholesterol on usual care while LDL-cholesterol rose significantly. Neither regimen had any effect on HDL-cholesterol. Diurnal triglycerides as a presumptive measure of IDL in the intervention group were diminished by 39%. The study demonstrates the feasibility of a diet and exercise regimen to normalize mildly elevated plasma lipid levels and thus to possibly affect the course of coronary heart disease without drugs.
authors.affiliation: Klinisches Institut für Herzinfarktforschung, Medizinischen Universitäts-Klinik Heidelberg.
authors.forename: G
authors.initials: G
authors.lastname: Schlierf
authors.forename: G
authors.initials: G
authors.lastname: Schuler
authors.forename: A
authors.initials: A
authors.lastname: Wirth
authors.forename: M
authors.initials: M
authors.lastname: Kohlmeier
authors.forename: G
authors.initials: G
authors.lastname: Vogel
mesh_terms: D002784:Cholesterol / Q000097:blood; D002940:Circadian Rhythm; D003327:Coronary Disease / Q000097:blood / Q000628:therapy*; D004041:Dietary Fats / Q000008:administration & dosage*; D015444:Exercise; D005215:Fasting; D005500:Follow-Up Studies; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D014280:Triglycerides / Q000097:blood
chemical_list: D004041:Dietary Fats; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol