[Dependence of the reversal training of rats in a Y-maze and their haloperidol sensitivity on the estrous cycle phase].
In female rats estrous cycle related variations were found in reversal learning in a Y-maze. Low intersession fluctuations of errors and a high number of well relearning rats were obtained on the day of diestrus I as compared with estrus. The improvement of avoidance behaviour by haloperidol (0.1 mg/kg) also was better in diestrus I. The estrous cycle dependent variations of the behavior and neuroleptic effect may be a result of periodicity of ovarial hormones secretion and their influences on the brain dopaminergic systems.
Arushanian
E B
EB
Borovkova
G K
GK
Koneev
S V
SV
Tereshkin
O V
OV
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D004971:Estrus / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012193:Reversal Learning / Q000187:drug effects / Q000502:physiology*
D006220:Haloperidol
Zavisimost' pereobucheniia krys v Y-obraznom labirinte i ikh chuvstvitel'nosti k galoperidolu ot faxy éstral'nogo tsikla.