[A method for inducing gallbladder cancer in Syrian hamsters].
The 8-10 weeks male Syrian hamsters were inserted beeswax pellets into the gallbladder, the pellets contained 5 mg of 3-methylcholanthrene (group IV). In control groups the animals were inserted intravesical beeswax pellets or subjected to a sham-operation (group I, II, III). The experiment lasted for 34 weeks, the first tumours were obtained 21 weeks after the operation. The tumours of gallbladder were obtained in group IV in 23 of 42 animals which lived for more than a month (54.2%). The first results of the experiment allow estimating positively the method, which permits due to the exact performance of the described details obtaining a number of tumours sufficient for studying the tumours of the gallbladder in a comparatively short period.
Gorin
B Ia
BIa
Krutovskikh
V A
VA
D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D004343:Drug Implants; D005704:Gallbladder / Q000473:pathology; D005706:Gallbladder Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008647:Mesocricetus; D008722:Methods; D008748:Methylcholanthrene / Q000008:administration & dosage; D013997:Time Factors; D014885:Waxes
D004343:Drug Implants; D014885:Waxes; C038228:beeswax; D008748:Methylcholanthrene
Metodika indutsirovaniia raka zhelchnogo puzyria u siriĭskikh khomiakov.