2-Chloroadenosine prevents kainic acid-induced toxicity in rat striatum.
The stable adenosine analogue, 2-chloroadenosine was found to afford a dose-dependent protection (effective dose range: 12.5-50 nmol) against the characteristic neurotoxic actions of kainic acid (2.2 nmol) in rat striatum. The two agents were co-injected directly into the striatum and the extent of the excitotoxin-induced lesion assessed two weeks later in 40 microns coronal sections stained with thionin, or by histochemical staining for NADPH-dependent diaphorase. These findings provide further information concerning the possible mechanism(s) underlying kainic acid-induced neurotoxicity and also yield an insight into a possible neuroprotective role for endogenous adenosine-like substances.
Arvin
B
B
Department of Physiology and Pharmacology, University of Southampton, U.K.
Neville
L F
LF
Roberts
P J
PJ
D015762:2-Chloroadenosine; D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects*; D007608:Kainic Acid / Q000037:antagonists & inhibitors* / Q000633:toxicity; D008297:Male; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009125:Muscle Relaxants, Central; D015762:2-Chloroadenosine; D000241:Adenosine; D007608:Kainic Acid