A 2-amino-2-oxazoline derivative as an antidepressant in mice.
2-Amino-2-oxazolines are heterocyclic compounds with interesting pharmacological properties. Several derivatives of this chemical series were studied in psychopharmacological tests. One derivative 4,5-dihydro-5-[methyl(4-phenyl-1-piperazinyl)]-2-oxazolamine (COR 32-24), had an antidepressant profile. Its structure can be compared to trazodone in its phenylpiperazine group and to toloxatone in its oxazoline group. This molecule antagonized reserpine-induced hypothermia and ptosis, oxotremorine-induced hypothermia and high-dose apomorphine-induced hypothermia. It also potentiated yohimbine-induced sublethality and decreased the immobility of forced swimming. It had no monoamine oxidase inhibitory activity. These results suggest a profile close to that of viloxazine and to that of a classic antidepressant.
Bourin
M
M
Laboratoire de Pharmacologie, Faculté de Médecine, Nantes, France.
Creuzet
M H
MH
Jarry
C
C
Colombel
M C
MC
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000037:antagonists & inhibitors; D001462:Barbital / Q000494:pharmacology; D004347:Drug Interactions; D006380:Helplessness, Learned / Q000523:psychology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010080:Oxazoles / Q000494:pharmacology*; D010095:Oxotremorine / Q000037:antagonists & inhibitors; D010424:Pentobarbital / Q000494:pharmacology; D004856:Postural Balance / Q000187:drug effects; D012110:Reserpine / Q000037:antagonists & inhibitors; D015016:Yohimbine / Q000037:antagonists & inhibitors
D000928:Antidepressive Agents; D010080:Oxazoles; D015016:Yohimbine; D010095:Oxotremorine; D001462:Barbital; D012110:Reserpine; C056984:COR 32-24; D006916:5-Hydroxytryptophan; D000661:Amphetamine; D010424:Pentobarbital; D001058:Apomorphine