[Experimental study of the hepatoprotective effect of transcranial transcutaneous electrostimulation and the synthetic analog of leu-enkephalin dalargin].
Results obtained from the study of mechanisms of hepatoprotective effect of transcranial transcutaneous electrostimulation are cited (TTES). In experiments on cholestase and pancreatitis models in rats we studied hepatospecific enzymes i.e. histidase and urokininanse in blood and liver and membrane-linked enzyme 5'-nucleotidase in the liver tissue. We made three series of experiments: 1 - TTES + valium, 2 - synthetis hexapeptide (SH) - leuenkephaline analog; 3 - TTES + valium + SH. Results obtained from experiments showed that mechanisms of TTES hepatoprotective action are in part conditioned by endogenous opiopeptides mobilization which produced membranestabilizing effect on the hepatocyte. We concluded that in patients with hepatic pathology it was reasonable to combine the electroanesthesia with SH.
Kuzin
M I
MI
Karelin
A A
AA
Korotkina
R N
RN
Babkina
N V
NV
Shloznikov
B M
BM
D000818:Animals; D001921:Brain / Q000502:physiology*; D004599:Electric Stimulation Therapy; D004580:Electronarcosis; D004723:Endorphins / Q000502:physiology; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D006638:Histidine Ammonia-Lyase / Q000097:blood; D008099:Liver / Q000201:enzymology*; D008107:Liver Diseases / Q000201:enzymology / Q000517:prevention & control*; D008297:Male; D051381:Rats; D004561:Transcutaneous Electric Nerve Stimulation; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood
D004723:Endorphins; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D014568:Urokinase-Type Plasminogen Activator; D006638:Histidine Ammonia-Lyase; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Izuchenie v éksperimente gepatoprotektornogo deĭstviia transkranial'noĭ chreskozhnoĭ élektrostimuliatsii i sinteticheskogoanaloga leĭ-enkefalina dalargina.