title: [Preparation and testing of polymer drugs. 4. Water-soluble polymer drugs with a base of vinylpyrrolidone-maleic acid anhydride-copolymers].
abstract: Watersoluble polymeric drugs were synthesized on the basis of alternating copolymer of 1-vinyl-2-pyrrolidone and maleic anhydride. Benzocain served as model drug. The drug was bound directly as well as about epsilon-aminocapronic acid as spacer. The pancreatin catalyzed hydrolysis of these polymeric drugs was studied. No hydrolysis was noted, if the drug is directly bound on the copolymer. The polymeric drug with the epsilon-aminocapronic acid as spacer showed a small release. Possible reasons for these facts are discussed.
authors.affiliation: Sektion Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Saale.
authors.forename: R
authors.initials: R
authors.lastname: Mank
authors.forename: H
authors.initials: H
authors.lastname: Kala
authors.forename: M
authors.initials: M
authors.lastname: Strube
authors.forename: J
authors.initials: J
authors.lastname: Traue
authors.forename: R
authors.initials: R
authors.lastname: Schneider
mesh_terms: D015119:Aminocaproic Acid / Q000032:analysis; D001566:Benzocaine / Q000032:analysis; D002626:Chemistry, Pharmaceutical; D005663:Furans / Q000032:analysis*; D008299:Maleic Anhydrides / Q000032:analysis*; D011108:Polymers; D011205:Povidone / Q000032:analysis*; D012995:Solubility
chemical_list: D005663:Furans; D008299:Maleic Anhydrides; D011108:Polymers; D011205:Povidone; D001566:Benzocaine; D015119:Aminocaproic Acid
vernacular_title: Darstellung und Testung von Polymerpharmaka. 4. Mitteilung: Wasserlösliche Polymerpharmaka auf der Basis von Vinylpyrrolidon-Maleinsäureanhydrid-Copolymeren.