title: Transtympanic administration of aminoglycosides in patients with Menière's disease.
abstract: Transtympanic administration of gentamicin was used to treat patients with unilateral Menière's disease and was stopped at the first signs of damage to cochlear and/or vestibular function. Twenty-eight patients were treated between 1974 and 1981 and 34 patients were managed between 1981 and 1987. In the two groups of patients, objective vertigo disappeared in 85%, hearing improved in 26%, aural fullness disappeared in 78%, while tinnitus ceased altogether in 51% and became less intense in 24%. Our findings show that this kind of treatment can be used after unsuccessful medical therapy and prior to any labyrinthine or endolymphatic sac surgery.
authors.affiliation: ENT Department, Hospital of Mestre, Venice, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Sala
mesh_terms: D004333:Drug Administration Routes; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008575:Meniere Disease / Q000188:drug therapy*; D014432:Tympanic Membrane
chemical_list: D005839:Gentamicins