title: Direct chromosome analysis from neonatal cord blood.
abstract: Direct chromosome preparations of neonatal cord blood provides the unique opportunity for rapid chromosome analysis (turnaround time; 6 hr), without the necessity of bone marrow aspiration. Based on 42 samples we confirm the finding of Garnham and Sutherland [1987] for suitability of cord blood for direct chromosome preparation. Procedural modifications are provided for higher yield of cells for chromosome analysis. The procedure may well be of major significance for rapid diagnosis of neonates who suffer from aneusomy.
authors.affiliation: Texas Genetic Screening and Counseling Service, Denton 76202-2467.
authors.forename: D W
authors.initials: DW
authors.lastname: Day
authors.forename: S M
authors.initials: SM
authors.lastname: Jalal
authors.forename: L
authors.initials: L
authors.lastname: Sinclair-Worley
authors.forename: M
authors.initials: M
authors.lastname: Kukolich
authors.forename: M
authors.initials: M
authors.lastname: Freeman
authors.forename: J
authors.initials: J
authors.lastname: Sakakini
mesh_terms: D001399:Azure Stains; D002871:Chromosome Banding; D002875:Chromosomes / Q000648:ultrastructure*; D003201:Computers; D005312:Fetal Blood / Q000166:cytology*; D006801:Humans; D007231:Infant, Newborn; D008677:Metaphase
chemical_list: D001399:Azure Stains