Different effects of vitamin E on the growth and morphological differentiation of 4 murine neuroblastoma cell lines in vitro.
The effects of vitamin E (vit.E, d-alpha-tocopherol acid succinate) on the growth and the morphological differentiation of 4 representative murine neuroblastoma cell lines: C1300 (wild type), NS-20 (cholinergic type), N-18 (inactive type), N1E-115 (adrenergic type), and the combined effects of vit.E and cis-diamminedichloroplatinum(II)(cisplatin, CDDP) were studied in culture. Vitamin E inhibited the growth of all clonal cells in a dose-dependent manner, especially that of NS-20 cells, and it caused significant morphological differentiation only in NS-20 cells. In addition, vit.E enhanced the growth inhibition of C1300 cells by cisplatin in an additive manner, but not that of NS-20 cells. These suggested that both phenomena induced by vit.E may not always occur in parallel in each clonal neuroblastoma, and both mechanisms might be different.
Sué
K
K
Department of Paediatric Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Nakagawara
A
A
Okuzono
S
S
Fukushige
T
T
Ikeda
K
K
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002945:Cisplatin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D051379:Mice; D009447:Neuroblastoma / Q000473:pathology; D024505:Tocopherols; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology
D014810:Vitamin E; D002945:Cisplatin; D024505:Tocopherols