title: Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride.
abstract: The (R)-(+)- and (S)-(-)-enantiomers of the anticholinergic compound, oxyphencyclimine, were synthesized from (R)-(-)- and (S)-(+)-2-cyclohexyl-2-hydroxy-2-phenylethanoic acid, respectively. The potencies of the enantiomers were compared using a cholinergic receptor binding assay. The (R)-(+)-enantiomer inhibited binding 29 times more potently than the (S)-(-)-enantiomer.
authors.affiliation: Department of Chemistry, Agricultural University of Norway.
authors.forename: L
authors.initials: L
authors.lastname: Schjelderup
authors.forename: M R
authors.initials: MR
authors.lastname: Kozlowski
authors.forename: A
authors.initials: A
authors.lastname: Weissman
authors.forename: A J
authors.initials: AJ
authors.lastname: Aasen
mesh_terms: D000818:Animals; D002417:Cattle; D002540:Cerebral Cortex / Q000378:metabolism; D010276:Parasympatholytics / Q000138:chemical synthesis / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology*; D011813:Quinuclidinyl Benzilate / Q000037:antagonists & inhibitors; D011976:Receptors, Muscarinic / Q000187:drug effects*; D013237:Stereoisomerism
chemical_list: D010276:Parasympatholytics; D011743:Pyrimidines; D011976:Receptors, Muscarinic; C100201:oxyphencyclimine; D011813:Quinuclidinyl Benzilate