Experimental intracerebral haemorrhage: the effect of nimodipine pretreatment.
The effect of pretreatment with the calcium antagonist nimodipine on the pathophysiological events which follow an intracerebral haemorrhage in rats was compared with a similar control group. Cerebral blood flow was higher and the amount of pathologically determined ischaemic damage measured by light microscopy was less in the nimodipine pretreated group. Bloodbrain barrier permeability was increased in the nimodipine group, but there was no evidence of cerebral oedema. Nimodipine appeared to have no effect on the intracranial pressure.
Sinar
E J
EJ
Department of Neurosurgery, Newcastle General Hospital, Newcastle Upon Tyne, UK.
Mendelow
A D
AD
Graham
D I
DI
Teasdale
G M
GM
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000473:pathology; D002199:Capillary Permeability / Q000187:drug effects; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D007427:Intracranial Pressure / Q000187:drug effects; D008297:Male; D009553:Nimodipine / Q000627:therapeutic use*; D010100:Oxygen / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
D009553:Nimodipine; D010100:Oxygen