title: Antimicrobial activity of MDL 19,592: an oral cephalosporin.
abstract: MDL 19,592, a semisynthetic oral cephalosporin, has an antimicrobial spectrum principally directed against Gram-positive cocci (MIC50, 0.25-4 micrograms/ml), Branhamella catarrhalis (MIC50, 1-2 micrograms/ml), and pathogenic Neisseria spp. such as meningococci (MIC50, 4 micrograms/ml). Enterobacteriaceae, enterococci, Pseudomonas spp., Corynebacterium jeikeium, and Acinetobacter calcoaceticus strains had MDL 19,592 MIC50 of greater than or equal to 32 micrograms/ml. Although MDL 19,592 generally had a spectrum most similar to cefadroxil, it could not be represented by the cephalothin susceptibility test because of low predictive values and MIC correlations.
authors.affiliation: Clinical Microbiology Institute, Tualatin, Oregon 97062.
authors.forename: R N
authors.initials: RN
authors.lastname: Jones
authors.forename: A L
authors.initials: AL
authors.lastname: Barry
mesh_terms: D000150:Acinetobacter / Q000187:drug effects; D000667:Ampicillin / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002434:Cefadroxil / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D002512:Cephalothin / Q000494:pharmacology; D003352:Corynebacterium / Q000187:drug effects; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009343:Neisseria / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
chemical_list: D002511:Cephalosporins; D002434:Cefadroxil; C039872:MDL 19592; D000667:Ampicillin; D002512:Cephalothin