Chronic ethanol treatment of rats reduces RNA polymerase activity in isolated liver nuclei.
The effect of acute and chronic ethanol treatment of rats on the activity of RNA polymerases I and II in isolated nuclei has been studied. Results indicate that acute ethanol administration does not change the activity of the nuclear RNA polymerases while chronic ethanol treatment significantly reduces the activity of both RNA polymerases I and II.
Boyadjiev
S
S
Medico-Biological Institute, Medical Academy, Sofia, Bulgaria.
Boyadjieva
N
N
Pironcheva
G
G
Karagyozov
L
L
D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000201:enzymology
D000431:Ethanol; D012321:DNA-Directed RNA Polymerases