title: Experimental carbon tetrachloride-induced cirrhosis of the liver.
abstract: The authors produced an experimental model of cirrhosis by administering carbon tetrachloride (CCl4) intraperitoneally over 46 weeks to female Wistar rats at a dose of 0.2 ml of a solution of CCl4 in 33% mineral oil. The cytotoxic effect on the liver of this substance was evaluated in different developmental stages of the process by macroscopic, microscopic and ultrastructural studies.
authors.affiliation: Department of Pathology, School of Medicine, University of Salamanca, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Muñoz Torres
authors.forename: J I
authors.initials: JI
authors.lastname: Paz Bouza
authors.forename: M M
authors.initials: MM
authors.lastname: Abad Hernandez
authors.forename: M J
authors.initials: MJ
authors.lastname: Alonso Martin
authors.forename: A
authors.initials: A
authors.lastname: Lopez Bravo
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000166:cytology / Q000473:pathology / Q000648:ultrastructure; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002251:Carbon Tetrachloride