title: Stizolobic acid, a competitive antagonist of the quisqualate-type receptor at the crayfish neuromuscular junction.
abstract: Stizolobic acid and stizolobinic acid are amino acids isolated from a plant, Stizolobium hassjoo. Both amino acids reduced responses to glutamate and quisqualate in a competitive manner at the crayfish neuromuscular junction, without affecting responses to GABA and acromelic acid. Excitatory junctional potentials were decreased in the presence of stizolobic or stizolobinic acid in a concentration dependent manner. Stizolobinic acid was about 5 times less potent than stizolobic acid.
authors.affiliation: Tokyo Metropolitan Institute of Medical Science, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Shinozaki
authors.forename: M
authors.initials: M
authors.lastname: Ishida
mesh_terms: D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology*; D000818:Animals; D003400:Astacoidea; D009469:Neuromuscular Junction / Q000187:drug effects*
chemical_list: D000600:Amino Acids, Dicarboxylic; C013261:stizolobic acid