[Characteristics of chronic liver diseases with the presence of serum markers of the hepatitis B virus].
Different patterns of serum HBV markers (HBsAg, HBsAb, HBeAg, HBeAb, HBcAb) were identified in 82 patients (12 with chronic active hepatitis, 67 with hepato-cirrhosis developing in the outcome of chronic active hepatitis, and in 3 with primary biliary cirrhosis) of 105 (78%) patients with chronic liver diseases. Besides, IgM HBcAb were identified in 9 of 47 patients (19.1%), HBsAg IgM in 4 of 9 patients (44.4%), antibodies to the delta-agent in 8 of 23 (34.8%) suffering from chronic liver diseases with the presence of serum HBV markers. Chronic liver diseases with the presence of HBsAg and/or other serum HBV markers were characterized by a variety of clinico-laboratory manifestations determined by the involvement of some organs and systems in a process. A degree of activity of chronic liver diseases was not correlated with a replication phase, an integration phase, and an immunological resolution phase in 49 patients with identified phases of development of HBV-infection. More frequent identification of serum HBV markers including those of a replication phase was not noticed among patients on prolonged immunosuppressant therapy.
Aprosina
Z G
ZG
Lopatkina
T N
TN
Iakovenko
E P
EP
Krel'
P E
PE
Saiapina
E S
ES
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D002908:Chronic Disease; D005260:Female; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006511:Hepatitis B Antigens / Q000032:analysis*; D006521:Hepatitis, Chronic / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008103:Liver Cirrhosis / Q000276:immunology; D008105:Liver Cirrhosis, Biliary / Q000276:immunology; D008107:Liver Diseases / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens; D007075:Immunoglobulin M
Kharakteristika khronicheskikh zabolevaniĭ pecheni s nalichiem syvorotochnykh markerov virusa gepatita B.