Isolation and identification of an anti-inflammatory principle from Capparis spinosa.
The homologous polyprenols cappaprenol-12 (1), cappaprenol-13 (2) and cappaprenol-14 (3) with 12, 13 and 14 isoprene units, respectively, could be isolated by preparative HPLC from alcoholic extracts of Capparis spinosa. Testing 2 for its anti-inflammatory activity an inhibition of the carrageenan-induced paw edema in rats of 44 vs. 67% for the standard oxyphenbutazone was found.
al-Said
M S
MS
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Abdelsattar
E A
EA
Khalifa
S I
SI
el-Feraly
F S
FS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis / Q000302:isolation & purification*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010936:Plant Extracts / Q000032:analysis; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D012529:Saudi Arabia; D013055:Spectrophotometry, Infrared
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D002351:Carrageenan