Development of tolerance to pethidine in rats, pretreated or not, with beta-naphtoflavone or SKF 525 A.
Tolerance to the analgesic effect of pethidine (PD) in rats, treated with a dose of 15 mg/kg of the compound twice daily at 12 h intervals for 1-3 weeks, was assessed using both, heat and current irritating stimuli. Tolerance could be detected earlier by the current irritating method, than by the hot plate technique. Pretreatment with beta-naphtoflavone did only slightly affect the development of tolerance to the antinociceptive effect of PD. In contrast after one week of treatment with SKF 525 A PD retained its analgesic effect. The prolonged pretreatment with SKF 525 A did not prevent the development of tolerance to the analgesic effect of PD.
Cenajek
D
D
Department of Pharmacology, School of Medicine, Poznan.
Szczawińska
K
K
Chodera
A
A
Nowakowska
E
E
D000818:Animals; D001571:Benzoflavones / Q000494:pharmacology*; D004361:Drug Tolerance; D005419:Flavonoids / Q000494:pharmacology*; D008297:Male; D008614:Meperidine / Q000494:pharmacology*; D011335:Proadifen / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D019324:beta-Naphthoflavone
D001571:Benzoflavones; D005419:Flavonoids; D019324:beta-Naphthoflavone; D008614:Meperidine; D011335:Proadifen