title: Interleukin-1 is an astroglial growth factor in the developing brain.
abstract: The immunomodulator interleukin-1 (IL-1) is found to be an astroglial growth factor during development of the mammalian brain. In vitro studies indicate that ameboid microglia, a class of brain mononuclear phagocytes, are the likely source of IL-1. Examination of different brain regions during development shows IL-1 production only after the appearance of ameboid microglia. These observations suggest that brain mononuclear phagocytes secrete growth factors that regulate normal growth and development of the CNS.
authors.affiliation: Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.
authors.forename: D
authors.initials: D
authors.lastname: Giulian
authors.forename: D G
authors.initials: DG
authors.lastname: Young
authors.forename: J
authors.initials: J
authors.lastname: Woodward
authors.forename: D C
authors.initials: DC
authors.lastname: Brown
authors.forename: L B
authors.initials: LB
authors.lastname: Lachman
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism* / Q000502:physiology; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D007375:Interleukin-1 / Q000378:metabolism* / Q000502:physiology; D010586:Phagocytes / Q000378:metabolism; D051381:Rats
chemical_list: D007375:Interleukin-1