[In vitro 3H-vincristine accumulation as a possible marker of the sensitivity of animal and human leukemic cells to the preparation].
The uptake of 3H-vincristine into the leukemic cells of animals and blast cells of peripheral blood of patients with leukemia has been studied. The capacity of cells to accumulate the drug is found to be of significant value for their sensitivity to vincristine. The in vitro low-alkaloid accumulation (less than 18 pmol/mg protein) by cells is an unfavourable prognostic sign for vincristine chemotherapy.
Sidorova
T A
TA
Volkova
M A
MA
D000818:Animals; D001782:Blood Donors; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000378:metabolism*; D007942:Leukemia, Experimental / Q000188:drug therapy / Q000378:metabolism*; D051379:Mice; D011379:Prognosis; D014316:Tritium; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000493:pharmacokinetics* / Q000627:therapeutic use
D014316:Tritium; D014750:Vincristine
Nakoplenie 3H-vinkristina in vitro kak vozmozhnyĭ marker chuvstvitel'nosti leĭkoznykh kletok zhivotnykh i cheloveka k preparatu.