Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region.
A variable region (V delta 5) of the T-cell receptor (TcR) delta chain that is preferentially expressed in adult murine thymocytes is located 2.5 kilobases 3' of the constant region (C delta) element. The V delta 5 coding sequence is in a transcriptional orientation opposite the J delta (joining region) and C delta coding elements and rearranges by inversion. The C delta is divided into four exons, three of which encode amino acids of TcR delta polypeptide, and the fourth comprises the entire 3' untranslated region. In this respect, C delta resembles C alpha rather than C beta or C gamma.
Iwashima
M
M
Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305.
Green
A
A
Davis
M M
MM
Chien
Y H
YH
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005803:Genes, Immunoglobulin; D007127:Immunoglobulin Constant Regions / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology*
D007127:Immunoglobulin Constant Regions; D007135:Immunoglobulin Variable Region; D011948:Receptors, Antigen, T-Cell