Human pregnancy-specific beta 1-glycoprotein: a new member of the carcinoembryonic antigen gene family.
The amino acid sequence of human pregnancy-specific beta 1-glycoprotein (PS beta G) as deduced from the cDNA sequence contains two repeated protein domains (1a and 2a) of 93 amino acids each. PS beta G shows strong homology to human carcinoembryonic antigen (CEA) at both nucleotide and amino acid levels. CEA contains eight domains including a N-terminal domain, three repeated domains (I, II, and III), each containing two subdomains (A and B), and a hydrophobic carboxyl-terminal domain. PS beta G contains a CEA-like N-terminal domain, two repeated domains similar to the A subdomains of CEA which is followed by a domain (1b) similar to the B subdomains of CEA, but lacks a hydrophobic carboxyl-terminal domain. The positions of the cysteine residues in each domain also are conserved, indicating that PS beta G and CEA are two members of the same gene family.
Watanabe
S
S
Human Genetics Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.
Chou
J Y
JY
D000595:Amino Acid Sequence; D001483:Base Sequence; D002272:Carcinoembryonic Antigen / Q000235:genetics*; D003001:Cloning, Molecular; D004247:DNA / Q000302:isolation & purification; D005260:Female; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000235:genetics*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000235:genetics* / Q000302:isolation & purification; D021382:Protein Sorting Signals / Q000302:isolation & purification; D012091:Repetitive Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid
D002272:Carcinoembryonic Antigen; D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins; D021382:Protein Sorting Signals; D004247:DNA