The reduction of pain on injection of propofol: the effect of addition of lignocaine.
The effects of addition of 1 ml of lignocaine (10 mg) or isotonic saline to 19 ml of the emulsified preparation of propofol (Diprivan) were studied in a randomised, double-blind trial in 80 patients. The incidence and severity of pain on injection of propofol were significantly reduced by the addition of lignocaine (P less than 0.01).
Helbo-Hansen
S
S
Odense University Hospital, Department of Anaesthesiology, Denmark.
Westergaard
V
V
Krogh
B L
BL
Svendsen
H P
HP
D000293:Adolescent; D000328:Adult; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D000777:Anesthetics / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects; D008012:Lidocaine / Q000008:administration & dosage*; D008875:Middle Aged; D010146:Pain / Q000517:prevention & control*; D010636:Phenols / Q000008:administration & dosage*; D015742:Propofol; D011897:Random Allocation; D012965:Sodium Chloride / Q000008:administration & dosage
D000777:Anesthetics; D010636:Phenols; D012965:Sodium Chloride; D008012:Lidocaine; D015742:Propofol