Screening of blood donors for antibody to human immunodeficiency virus type I by sensitive particle agglutination assay.
A particle agglutination (PA) assay for antibody to human immunodeficiency virus type I (anti-HIV) was used to screen blood donors and to test leukemia and hemophilia patients. Results by PA showed complete agreement with the results of two kinds of enzyme immunoassay (EIA), and the false-positive rate was the same as or lower than with the EIAs. The sensitivity of PA was 10- to 100-fold higher than that of the EIAs. This simple sensitive assay takes less time and fewer personnel than the EIAs, and has been used for massive screening of blood donors in our blood center.
Ohya
K
K
Aichi Blood Center Japanese Red Cross Society, Japan.
Morishima
Y
Y
Funato
E
E
Hasegawa
I
I
Kamiya
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000372:Agglutination Tests; D001782:Blood Donors; D015483:HIV Antibodies / Q000032:analysis*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged
D015483:HIV Antibodies