title: Diabetic cardiomyopathy: the relationship between 201-thallium myocardial scintigraphic perfusion defect and left ventricular function in asymptomatic diabetics.
abstract: To investigate the significance of perfusion defects in asymptomatic diabetics, 40 mildly diabetic men, mean age 49 +/- 9.7 years, without clinical or exercise electrocardiographic evidence of ischemic cardiac disease, were evaluated: 1) sixteen (40%) showed no filling defect (G1). Mild defects (G2) and moderate defects (G3) were observed in 12 and 12, respectively; 2) the percent washout ratio was diminished in none of G1, in 3 of G2 and in 11 of G3; 3) there were no differences in age, duration of diabetes, FBS, HbA1c, serum cholesterol, smoking or BP. Obesity index was greater in G3 (121 +/- 15%, p less than 0.01) compared to G1 and 2 (103 +/- 9%, 108 +/- 9%); 4) the percent fractional shortening by echo was decreased in G2 and G3 (35 +/- 6%, 33 +/- 8%, p less than 0.01) compared to G1 (42 +/- 5%). The systolic time interval was higher in G3 (0.42 +/- 0.09, p less than 0.05) compared to G1 and G2 (0.35 +/- 0.05, 0.36 +/- 0.06); 5) radionuclide ventriculographic studies showed a lower peak filling rate at rest in G2 (2.4 +/- 0.5 EDV/sec, p less than 0.025) compared to G3 and G1 (2.9 +/- 0.6 EDV/sec, 3.2 +/- 0.7 EDV/sec). The rate of increase in cardiac output was significantly lower in G3 compared to G1 and G2 (59 +/- 28%, 96 +/- 49%, 97 +/- 31%, p less than 0.05). These results suggest the possibility of detecting metabolic derangements was myocardial scintigraphic perfusion abnormalities which might be a causal factor of myocardial dysfunction in diabetics.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Amano
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: J
authors.initials: J
authors.lastname: Oku
authors.forename: K
authors.initials: K
authors.lastname: Fujinami
authors.forename: T
authors.initials: T
authors.lastname: Sugimoto
mesh_terms: D009202:Cardiomyopathies / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000209:etiology; D048909:Diabetes Complications; D004452:Echocardiography; D004562:Electrocardiography; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D005082:Physical Exertion; D013794:Thallium Radioisotopes; D014055:Tomography, Emission-Computed
chemical_list: D013794:Thallium Radioisotopes