Cloprostenol prevents reperfusion induced fibrillation in isolated Langendorff heart preparation of guinea-pigs.
Cloprostenol, a synthetic derivative of prostaglandin F2 alpha, exhibits antiarrhythmic properties against reperfusion induced fibrillation in guinea-pig hearts in vitro. It decreases the incidence of fibrillation from 75.0% to 0%. This antifibrillatory effect of cloprostenol could be confirmed also by in vivo experiments.
Riedel
A
A
Department of Pharmacology and Toxicology, Martin Luther University, Halle, GDR.
Desselberger
R
R
Mest
H J
HJ
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D003008:Cloprostenol / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D066298:In Vitro Techniques; D010477:Perfusion; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*
D011461:Prostaglandins F, Synthetic; D003008:Cloprostenol