Effects of anti-class I antibodies on proliferation of murine T lymphocytes.
Antibodies specific for the murine Class I H-2K/D molecules have been analyzed for their effect on the proliferation of murine T cells. Several antibodies specific for both private and public determinants have been found to inhibit lectin-mediated T-cell proliferation. These same antibodies do not noticeably effect growth factor-dependent proliferation of activated T cells and have been found to stimulate rather than inhibit alloantigen-induced proliferation of T cells. Taken together these results suggest that Class I molecules may have some functional role in the early events of T-cell stimulation/proliferation, although the mechanisms for antibody effect may be different for T cells stimulated in different ways.
O'Neill
H C
HC
Department of Experimental Pathology, John Curtin School of Medical Research, Canberra, Australia.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000502:physiology*; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens / Q000276:immunology*; D064532:Histocompatibility Antigen H-2D; D007519:Isoantigens / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000911:Antibodies, Monoclonal; D006183:H-2 Antigens; D064532:Histocompatibility Antigen H-2D; D007519:Isoantigens