Radiobrominated m-tyrosine analog as potential CNS L-dopa pet tracer.
Radiobrominated 6-bromo-m-tyrosine (6-BMT) was prepared and the time course of its localization in selected cerebral and peripheral organs in the mouse was determined. Since m-tyrosine is known to have L-dopa-like properties in vivo, our goal was to assess the utility of a radiolabeled analog as a tracer for cerebral L-dopa. Our preliminary results showed that substantial amounts of 6-BMT is extracted by the mouse brain and that the regional distribution and time course of the radiotracer is consistent with uptake in regions rich in dopamine neurons. Although a more thorough biochemical characterization of 6-BMT is necessary, this or other positron emitting analogs of m-tyrosine, such as an 18F labelled analog, may be useful PET tracers for the non-invasive study of dopamine turnover in humans.
De Jesus
O T
OT
Chemistry Division, Argonne National Laboratory, IL 60439.
Mukherjee
J
J
D000818:Animals; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D001967:Bromine Radioisotopes; D002531:Cerebellum / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D007980:Levodopa / Q000032:analysis*; D008099:Liver / Q000378:metabolism; D051379:Mice; D014055:Tomography, Emission-Computed; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D001967:Bromine Radioisotopes; C054892:6-bromo-m-tyrosine; D014443:Tyrosine; D007980:Levodopa