title: The effect of frontal cortex lesion on the activity of the dopaminergic system in rat striatum.
abstract: The experiment was carried out on male Wistar rats weighing 180-220 g with lesion in the cortex of the frontal lobe. The activity of the dopaminergic system was studied by means of behavioural tests such as determination of spontaneous motor activity, apomorphine-induced stereotypy, haloperidol-induced catalepsy. Increased intensity of stereotypy was observed reaching a maximum 14 days after frontal lobe damage. Moreover, a slight tendency was observed for inhibition of haloperidol-induced catalepsy without changes in the spontaneous motor activity of the animals. Biochemical investigations demonstrated reduced dopamine content in the striatum on the side of the lesion.
authors.affiliation: Department of Pharmacology, School of Medicine, Lublin.
authors.forename: M
authors.initials: M
authors.lastname: Sieklucka-Dziuba
authors.forename: A
authors.initials: A
authors.lastname: Wamil
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004298:Dopamine