[Specificity of mutagenic effect of N-nitroso-N-methylurea and relation between its mutagenic activity and carbamoylating properties].
Significance of carbamoylation for mutagenic effects of N-nitroso-N-methyl-urea (NMU) on the CHO-AT3-2 cell line of Chinese hamster was studied. True point mutations occurred, due to alkylation. Carbamoylation combined with alkylation, or carbamoylation after alkylation induced the increase in other types of gene mutations as well as micro- and macroaberrations. These effects may be explained by the synergistic effect of alkylation and carbamoylation. Possible mechanisms and levels of interaction between alkylation and carbamoylation are discussed.
Serebrianyĭ
A M
AM
Sal'nikova
L E
LE
Bakhitova
L M
LM
Pashin
Iu V
IuV
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006224:Cricetinae; D003412:Cricetulus; D008770:Methylnitrosourea / Q000633:toxicity*; D015162:Micronucleus Tests; D009153:Mutagens; D009154:Mutation; D011190:Potassium Cyanide / Q000633:toxicity
D009153:Mutagens; D008770:Methylnitrosourea; D011190:Potassium Cyanide
Spetsifichnost' mutagennogo deĭstviia N-nitrozo-N-metilmocheviny i sviaz' ee mutagennoĭ aktivnosti s karbamoiliruiushchimi svoĭstvami.