title: Evaluation of regional differences of tracer appearance time in cerebral tissues using [15O] water and dynamic positron emission tomography.
abstract: The tracer appearance time relative to the radial artery-sampling site has been evaluated in six brain locations in five human subjects using dynamic positron emission tomography (PET) following the bolus injection of H2(15)O. There was a maximum difference of +/- 2 s from the average in each location. To globally adjust the timing difference between the measured arterial curve and the PET scan, a correction method was developed based on a nonlinear least-squares fitting procedure. This new technique determined the global time delay with an accuracy of +/- 0.5 s. On the other hand, the linear backward extrapolation method resulted in a systematic error of 4 s.
authors.affiliation: Research Institute for Brain and Blood Vessels, Akita, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Iida
authors.forename: S
authors.initials: S
authors.lastname: Higano
authors.forename: N
authors.initials: N
authors.lastname: Tomura
authors.forename: F
authors.initials: F
authors.lastname: Shishido
authors.forename: I
authors.initials: I
authors.lastname: Kanno
authors.forename: S
authors.initials: S
authors.lastname: Miura
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Uemura
mesh_terms: D001921:Brain / Q000378:metabolism*; D006801:Humans; D010104:Oxygen Radioisotopes / Q000493:pharmacokinetics*; D014055:Tomography, Emission-Computed; D014867:Water / Q000493:pharmacokinetics*
chemical_list: D010104:Oxygen Radioisotopes; D014867:Water