[Interaction of the calcium salt of heparin with specific antagonists and ethacizine].
Protamine sulfate was shown to bind calcium heparinate isolated from the pig intestinal mucosa during in vitro experiments in 0.6:1 ration and during experiments on rabbits and dogs in 1.5:1 ratio. 2,5-ionen neutralizes the anticoagulant effect of calcium heparinate during in vitro and animal experiments in 0.6:1 ratio. Neutralization of calcium heparinate requires by approximately 30% more specific antagonists than neutralization of the same amount of sodium heparinate. Ethacizine was found in experiments on rabbits to decrease the anticoagulant effect of calcium heparinate to the same degree as does sodium heparinate.
Ushkalova
E A
EA
Petrov
A D
AD
Kremneva
V F
VF
Shcheglova
N V
NV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D006493:Heparin / Q000494:pharmacology*; D006494:Heparin Antagonists / Q000494:pharmacology*; D008297:Male; D010640:Phenothiazines / Q000494:pharmacology*; D011108:Polymers / Q000494:pharmacology; D011479:Protamines / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D006494:Heparin Antagonists; D010640:Phenothiazines; D011108:Polymers; D011479:Protamines; C006871:calcium heparin; C037043:2,5-ionene; D006493:Heparin; C046818:ethacizine
Izuchenie vzaimodeĭstviia kal'tsievoĭ soli geparina so spetsificheskimi antagonistami i étatsizinom.