title: Single photon emission computed tomography in AIDS dementia complex.
abstract: Single photon emission computed tomography (SPECT) studies were performed in AIDS dementia complex using IMP in 12 patients (and HM-PAO in four of these same patients). In all patients, SPECT revealed either multiple or focal uptake defects, the latter corresponding with focal signs or symptoms in all but one case. Computerized tomography showed a diffuse cerebral atrophy in eight of 12 patients, magnetic resonance imaging exhibited changes like atrophy and/or leukoencephalopathy in two of five cases. Our data indicate that both disturbance of cerebral amine metabolism and alteration of local perfusion share in the pathogenesis of AIDS dementia complex. SPECT is an important aid in the diagnosis of AIDS dementia complex and contributes to the understanding of the pathophysiological mechanisms of this disorder.
authors.affiliation: Neurological Department, University of Innsbruck, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Pohl
authors.forename: G
authors.initials: G
authors.lastname: Vogl
authors.forename: H
authors.initials: H
authors.lastname: Fill
authors.forename: H
authors.initials: H
authors.lastname: Rössler
authors.forename: R
authors.initials: R
authors.lastname: Zangerle
authors.forename: F
authors.initials: F
authors.lastname: Gerstenbrand
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000000981:diagnostic imaging*; D000328:Adult; D000661:Amphetamine; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D003704:Dementia / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009942:Organometallic Compounds; D010091:Oximes; D013667:Technetium; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed / Q000295:instrumentation
chemical_list: D007457:Iodine Radioisotopes; D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D013667:Technetium; D000661:Amphetamine