title: Effects of mephenytoin on schedule-controlled responding in the pigeon.
abstract: Acute and chronic effects of mephenytoin (30-360 mg/kg) were examined in pigeons responding under a multiple fixed-ratio 50 fixed-interval 90-sec schedule of food delivery. The highest dose administered acutely (240 mg/kg) produced substantial reductions in rate of responding under both components of the multiple schedule; the effects of other doses were small and inconsistent. With chronic exposure tolerance appeared to develop to the rate-decreasing effects of the drug.
authors.affiliation: Department of Psychology, Western Michigan University, Kalamazoo 49008.
authors.forename: V
authors.initials: V
authors.lastname: Pellettiere
authors.forename: D
authors.initials: D
authors.lastname: Delaney
authors.forename: H
authors.initials: H
authors.lastname: Schlinger
authors.forename: A
authors.initials: A
authors.lastname: Poling
mesh_terms: D000818:Animals; D010856:Columbidae; D005502:Food; D006827:Hydantoins / Q000494:pharmacology*; D008617:Mephenytoin / Q000008:administration & dosage / Q000494:pharmacology*; D011930:Reaction Time; D012055:Reinforcement Schedule
chemical_list: D006827:Hydantoins; D008617:Mephenytoin