Preparation of microcapsules from complex coacervation of Gantrez-gelatin. III. Bioavailability of nitrofurantoin microcapsules.
The bioavailability of marketed nitrofurantoin capsules was compared to capsules filled with Gantrez-gelatin nitrofurantoin microcapsules of a core:coat ratio of 1:2. The collective results obtained from the analysis of urine samples of five volunteers indicated that nitrofurantoin microcapsules provided a prolonged release compared with that of the control formulation. Analysis of variance showed statistically significant differences between the control formulation and the capsule filled with the microcapsule. Non-significant intersubject variation was noticed.
Mortada
S A
SA
Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Egypt.
el Egaky
M A
MA
Motawi
A M
AM
el Khodery
K A
KA
D000328:Adult; D001682:Biological Availability; D002214:Capsules; D003692:Delayed-Action Preparations; D006801:Humans; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine
D002214:Capsules; D003692:Delayed-Action Preparations; D009582:Nitrofurantoin