title: The effect of naftidrofuryl on PGF2 alpha, U 46.619, 5-HT and thromboxane A2 (TXA2) induced vasoconstriction.
abstract: This study was designed to investigate the effects of Naftidrofuryl on platelet function and vessel tone and additionally platelet vessel wall interactions. It is shown that Naftidrofuryl displays a spasmolytic activity against a variety of different vasoconstrictors, including 5-HT, PGF2 alpha, U 46.619 and KC1 and inhibits platelet secretion. These effects are observed at concentrations of the compound equal to or higher than 1 mumol/l and might contribute to the clinical efficacy of the drug.
authors.affiliation: Neurochirurgische Klinik, Universität Göttingen, FRG.
authors.forename: R
authors.initials: R
authors.lastname: Verheggen
authors.forename: K
authors.initials: K
authors.lastname: Schrör
mesh_terms: D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000818:Animals; D002417:Cattle; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology; D015237:Dinoprost / Q000494:pharmacology*; D005663:Furans / Q000494:pharmacology*; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D009257:Nafronyl / Q000494:pharmacology*; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology*; D013928:Thromboxane A2 / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D005663:Furans; D011450:Prostaglandin Endoperoxides, Synthetic; D012701:Serotonin; D009257:Nafronyl; D013928:Thromboxane A2; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D015237:Dinoprost