The sensitive period for the morphological effects of monocular deprivation in two nuclei of the tectofugal pathway of zebra finches.
Previous experiments with 2-deoxyglucose (2-DG) suggested the existence of a critical period for the effects of monocular deprivation in the nucleus rotundus of zebra finches. The present study concerns the time course of this sensitive period for the morphological effects of monocular deprivation in two areas of the tectofugal visual pathway of zebra finches, the nucleus rotundus of the thalamus and the telencephalic ectostriatum. Cell size and volume changes were measured in birds subjected to 40 days of unilateral eye closure starting at ages spaced regularly throughout the first 70 days of life. The results show that monocular deprivation markedly affects cell size in both areas if the treatment starts at one or 10 days posthatch. The differences between deprived and non-deprived neurons decline monotonically with increasing visual experience prior to deprivation. However, deprivation onset at day 40 again causes as severe effects as early monocular closure. Deprivation as from day 50 or later no longer leads to abnormalities. The measurements of the volume of the nucleus rotundus parallel the cell size measurements, with the exception that the second increase in sensitivity occurs with deprivation onset at day 50 instead of day 40. These data indicate that the time course of the sensitive period for the effects of monocular deprivation may be double-peaked: the sensitivity for external stimuli declines from hatch until day 30, but has another peak at 40-50 days of life. The definite end of the sensitive period, as determined with this method, can therefore be assumed to be at around day 50-60.
Herrmann
K
K
Universität Bielefeld, Fakultät für Biologie, Verhaltensphysiologie, F.R.G.
Bischof
H J
HJ
D000818:Animals; D001717:Birds / Q000033:anatomy & histology* / Q000254:growth & development; D003423:Critical Period, Psychological; D012683:Sensory Deprivation; D013687:Telencephalon / Q000166:cytology* / Q000254:growth & development; D013787:Thalamic Nuclei / Q000166:cytology* / Q000254:growth & development; D014785:Vision, Ocular