Assignment of a gene coding for a human T-cell antigen with a molecular weight of 40,000 daltons to chromosome 17.
Hybrid human-mouse T-cell clones reactive with Tp40 antibody, which detects cluster of differentiation (CD)7 antigen on human T lymphocytes, were established. Karyotype analysis showed that human chromosome 17 was essential for the expression of CD7 antigen. The presence of this chromosome was confirmed by enzyme analysis of galactokinase, which is coded by a gene on human chromosome 17.
Osada
S
S
Department of Pediatrics, Nagoya University School of Medicine, Japan.
Utsumi
K R
KR
Ueda
R
R
Akao
Y
Y
Tsuge
I
I
Nishida
K
K
Okada
J
J
Matsuoka
H
H
Takahashi
T
T
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D008970:Molecular Weight
D000945:Antigens, Differentiation, T-Lymphocyte