title: Wiskott-Aldrich syndrome in identical twins: abnormality of CD4 and CD8 positive lymphocytes.
abstract: The rare occurrence of Wiskott-Aldrich syndrome (WAS) in identical twin brothers without a preceding family history of the disease is described. Investigation into the nature of the lymphocyte abnormality in the surviving twin suggests that the frequency of T cell clone forming cells is markedly decreased. Further analysis of the T cell clones showed a deficiency of CD8 positive cytotoxic/suppressor cells. This alteration may be an underlying mechanism in the development of some of the clinical manifestations of WAS.
authors.affiliation: Flinders Medical Centre, SA.
authors.forename: K
authors.initials: K
authors.lastname: Forsyth
authors.forename: R
authors.initials: R
authors.lastname: Seshadri
authors.forename: C
authors.initials: C
authors.lastname: Matthews
authors.forename: R
authors.initials: R
authors.lastname: Heddle
mesh_terms: D000911:Antibodies, Monoclonal; D002999:Clone Cells / Q000276:immunology; D004200:Diseases in Twins; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010641:Phenotype; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D014430:Twins, Monozygotic; D014923:Wiskott-Aldrich Syndrome / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal