Dissolution of metronidazole from oral and vaginal dosage forms in sink and non-sink conditions.
The pharmaceutical availability of metronidazole from several commercial oral and vaginal dosage forms in sink and non-sink conditions has been examined by measuring the rate of drug dissolution. The results were interpreted by means of reversible and irreversible dissolution models. For non-sink conditions the reversible model was found to better interpret the data. The values of the relative dissolution rate constant, theoretical dissolution time and dissolution efficiency were obtained and discussed.
Bećirević
M
M
Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia, Yugoslavia.
Kallay
N
N
Senjković
R
R
D000282:Administration, Intravaginal; D000284:Administration, Oral; D007700:Kinetics; D008795:Metronidazole / Q000008:administration & dosage / Q000032:analysis*; D008956:Models, Chemical; D012995:Solubility; D013488:Suppositories / Q000032:analysis; D013607:Tablets / Q000032:analysis
D013488:Suppositories; D013607:Tablets; D008795:Metronidazole