Potent and comparable vasodilator actions of A- and B-calcitonin-gene-related peptides on the superficial subcutaneous vasculature of man.
1. Vasoactivity of human A- and B-calcitonin-gene-related peptides was studied in normal subjects, using reflectance plethysmography to measure relative changes in blood flow produced by superficial subcutaneous injections of the peptides. 2. Injection of 10(-11) mol of either peptide caused an immediate 200% increase in local blood flow and prolonged hyperaemia lasting up to 3 h. The hyperaemic response to 10(-13) mol of each peptide was significantly (P less than 0.01) smaller and shorter in duration than that elicited by 10(-11) mol of the same peptide, and 10(-15) mol of both peptides produced no hyperaemia other than that attributable to needle insertion alone. 3. At all three dosages examined, there were no significant differences between A- and B-calcitonin-gene-related peptides in magnitude or time course of the hyperaemic response. 4. Human A- and B-calcitonin-gene-related peptides are therefore potent vasodilators in man, causing comparable dose-related vasodilatation in the superficial tissues.
Williams
G
G
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Cardoso
H
H
Ball
J A
JA
Mulderry
P K
PK
Cooke
E
E
Bloom
S R
SR
D000293:Adolescent; D000328:Adult; D015740:Calcitonin Gene-Related Peptide; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology*; D010991:Plethysmography; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply*; D014665:Vasodilator Agents / Q000494:pharmacology*
D009479:Neuropeptides; D014665:Vasodilator Agents; D015740:Calcitonin Gene-Related Peptide