[Effect of metabolic changes in the liver on the cytotoxic activity of cyclophosphamide in the incisor of rats].
The incisor of the rat is a sensitive biological indicator which records nutritive and hormonal disorders as well as toxic influences. The present investigation was aimed to provide information whether or not the manifestation of cyclophosphamide-caused hypoplasias could be altered by an induction (phenobarbital) or inhibition (carbon tetrachloride) of the liver biotransformation capacity. Cyclophosphamide (15 or 30 mg/kg) was injected intraperitoneally. Pretreatment of the rat with phenobarbital produced an increase (35%) of the malformation, whereas carbon tetrachloride led to a dose dependent decrease (30 or 50%). Our investigations suggest that the cyclophosphamide induced defect of the incisor is due to an alteration of the metabolic liver function.
Rosenfeld
E
E
Martin-Luther-Universität, Halle-Wittenberg, Institut für Industrietoxikologie, Bereich Medizin, DDR.
Ponsold
W
W
Hoffmann
P
P
D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology; D003520:Cyclophosphamide / Q000633:toxicity*; D003804:Dentin / Q000187:drug effects / Q000473:pathology; D007180:Incisor / Q000187:drug effects / Q000473:pathology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D003520:Cyclophosphamide; D002251:Carbon Tetrachloride; D010634:Phenobarbital
Wirkung metabolischer Zustandsänderungen der Leber auf die zytotoxische Aktivität von Zyklophosphamid am Schneidezahn der Ratte.