Human plasma fluoride levels following intake of dentifrices containing aminefluoride or monofluorophosphate.
After single, oral doses, 8 h profiles of fluoride (F) concentrations in plasma were determined in healthy human volunteers. Bioavailability of F from four dentifrices with either aminefluoride (AMF) or monofluorophosphate (MFP) was compared with that of NaF. There were no significant differences with respect to F availabilities, plasma F peak levels and plasma F profiles between NaF and the dentifrices tested, regardless of the F compound, F content or further ingredients. From the pharmacokinetic data it is concluded that dentifrices with 0.02 per cent F or less markedly decrease the risk of inducing plasma F concentrations that might disturb enamel mineralization, even if large quantities of dentifrice are ingested by small children.
Trautner
K
K
Dental School, University of Würzburg, F.R.G.
Einwag
J
J
D000293:Adolescent; D000328:Adult; D000605:Amino Alcohols / Q000493:pharmacokinetics*; D001682:Biological Availability; D003802:Dentifrices; D005260:Female; D005459:Fluorides / Q000097:blood* / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D010710:Phosphates / Q000493:pharmacokinetics*
D000605:Amino Alcohols; D003802:Dentifrices; D010710:Phosphates; C012980:fluorophosphate; C036238:amine fluoride 297; D005459:Fluorides