[Effect of extracorporeal sorption on the content of free intracellular calcium of the leukocytes in atopic bronchial asthma].
Antigen-IgE-antibody interaction on the cell surface in an allergic reaction increases methylation of phospholipids of a cell membrane making it permeable for Ca2+ ions. Therefore of interest is a study of free intracellular Ca2+ concentration from a view-point of development of atopic bronchial asthma and the use of extracorporal methods of its therapy permitting the elimination of IgE-antibodies from the blood flow. The level of intracellular Ca2+ in the leukocytes of patients with atopic bronchial asthma was studied. It has been shown that 1. the fraction of leukocytes with a higher level of intracellular Ca2+ in patients with atopic bronchial asthma was increased as compared to healthy donors; 2. extracorporal sorption results in a decrease in the number of leukocytes with high Ca concentration.
Efendieva
I S
IS
Rudchenko
S A
SA
Kormosh
T
T
Khurkhulu
Z S
ZS
Grigorian
G Iu
GIu
D000328:Adult; D000936:Antigen-Antibody Complex / Q000627:therapeutic use*; D001249:Asthma / Q000097:blood / Q000628:therapy*; D002118:Calcium / Q000097:blood*; D002606:Charcoal; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D007164:Immunosorbents / Q000627:therapeutic use*; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012221:Rhinitis, Allergic, Perennial / Q000097:blood / Q000628:therapy; D012852:Sinusitis / Q000097:blood / Q000628:therapy
D000936:Antigen-Antibody Complex; D007164:Immunosorbents; D002606:Charcoal; D002118:Calcium
Issledovanie vliianiia ékstrakorporal'noĭ sorbtsii na soderzhanie svobodnogo vnutrikletochnogo kal'tsiia v leĭkotsitakh pri atopicheskoĭ bronkhial'noĭ astme.