[Immunopathology of the salivary glands of the lips in Sjögren's syndrome].
The cellular composition of the salivary gland infiltrates in primary Sjogren's syndrome and the presence of lymphokines were evaluated using the Avidin-Biotin-Peroxidase technique in 10 biopsies from Sjogren's syndrome patients. The predominant cell was the T-helper/inducer lymphocyte. T-helper/T-suppressor ratio ranged from 1/1 to 10/1. Only few M were observed while NK cells were rare. More than 50% (50-100%) of the infiltrating cells were HLA-DR positive while epithelial cells were positive from 40-90% in all but 2 cases in which the positivity was 10%. The infiltrating cells were also positive for Leu-10 antigen (40-95%) in contrast to the epithelial cells. Both infiltrating and epithelial cells were reacting with anti IL-2 MoAb in high percentages (50-100%), while none of the infiltrating cells expressed IL-2 receptor. Finally, 40-100% of the infiltrating cells were IFN-gamma positive. The above data indicate that a salivary gland lesion in Sjogren's syndrome is the result of an immune process in which T-lymphocytes predominate producing lymphokines while the epithelial cells by expressing class II MHC molecules, play an important role in the general picture.
Dalabanga
Y A
YA
Drosos
A A
AA
Moutsopoulos
H M
HM
D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count; D008046:Lip / Q000276:immunology / Q000473:pathology*; D008222:Lymphokines / Q000032:analysis; D012469:Salivary Glands / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000276:immunology / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*
D006684:HLA-DR Antigens; D008222:Lymphokines
Immunopatologiia sliunnykh zhelez gub pri sindrome Shegrena.