title: Mumps-induced opsoclonus-myoclonus and ataxia.
abstract: A 9-year-old boy manifested acute cerebellar ataxia associated with mumps infection. He developed opsoclonus, myoclonus, tremor, and truncal ataxia 7 days after mumps infection. Lumbar puncture revealed pleocytosis without elevation of protein; ELISA demonstrated an increased IgM titer of cerebrospinal fluid against mumps virus. From these results it was determined that acute cerebellar ataxia was induced by a direct invasion of mumps virus. Electroencephalography demonstrated normal background activity, although alpha-like activity appeared bilaterally in the frontal regions which was induced by eye closure and decreased by eye opening. Polygraphic electroencephalography revealed that the alpha-like activity corresponded to the ocular movement recorded above or lateral to the eyelids by electro-oculography; therefore, the alpha-like activity was considered to be derived from the opsoclonus which was secondary to cerebellar involvement. His neurologic symptoms improved gradually and resolved completely within 3 months after the onset of acute cerebellar ataxia.
authors.affiliation: Department of Pediatrics, Okayama University Medical School, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ichiba
authors.forename: Y
authors.initials: Y
authors.lastname: Miyake
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Oda
authors.forename: H
authors.initials: H
authors.lastname: Kimoto
mesh_terms: D002524:Cerebellar Ataxia / Q000209:etiology* / Q000503:physiopathology; D002648:Child; D006801:Humans; D008297:Male; D009107:Mumps / Q000150:complications*; D009207:Myoclonus / Q000209:etiology* / Q000503:physiopathology