Interstitial pneumonitis in antinuclear antibody-negative systemic lupus erythematosus: a new clinical manifestation and possible association with anti-Ro (SS-A) antibodies.
The clinical manifestations of patients with systemic lupus erythematosus (SLE) and negative fluorescent antinuclear antibody have been well documented. This report describes 2 cases of antinuclear antibody-negative SLE with antibodies only to Ro (SS-A) and the previously unreported clinical manifestation of lupus interstitial pneumonitis. A review of all SLE patients from 1984-1986 with interstitial pneumonitis revealed that 10 of the 12 patients had antibodies to Ro (SS-A). The frequency of anti-Ro (SS-A) with interstitial pneumonitis in SLE patients suggests a possible association between the two.
Hedgpeth
M T
MT
Tulane University Medical Center, New Orleans, LA 70112.
Boulware
D W
DW
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D011241:Prednisone / Q000627:therapeutic use; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D011859:Radiography
D000974:Antibodies, Antinuclear; C035356:SS-A antibodies; D011241:Prednisone