Immunologic studies in Darier's disease.
Humoral and cellular immunity were evaluated in 10 patients with Darier's disease. The mean levels of serum immunoglobulins, serum complement, peripheral macrophages, and peripheral B and T lymphocytes were within normal limits. Secretory IgA was present in all patients studied. Skin tests for delayed hypersensitivity revealed complete anergy in one of the eight patients tested. Lymphocyte transformation tests revealed statistically significant enhanced responsiveness to both PHA and ConA mitogens in several concentrations studied. These findings may suggest either the existence of alterations in immunoregulation of lymphocyte subpopulations in Darier's disease or may be limited to alterations in membrane functions of certain lymphocyte subpopulations which can be detected only in vitro. The role that such immunologic aberrations may play in the pathogenesis of Darier's disease is still obscure.
Halevy
S
S
Department of Dermatology, Beilinson Medical Center, Petah Tiqva, Israel.
Weltfriend
S
S
Pick
A I
AI
Weiss
H
H
Duczyminer-Kahana
M
M
Sandbank
M
M
D000328:Adult; D000368:Aged; D001402:B-Lymphocytes; D002452:Cell Count; D003165:Complement System Proteins / Q000032:analysis; D007644:Darier Disease / Q000150:complications / Q000235:genetics / Q000276:immunology*; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed; D007136:Immunoglobulins / Q000032:analysis; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008264:Macrophages; D008297:Male; D008875:Middle Aged; D012874:Skin Diseases, Infectious / Q000209:etiology; D013601:T-Lymphocytes
D007136:Immunoglobulins; D003165:Complement System Proteins