title: Alterations in the glomerulus in aminonucleoside nephrosis in analbuminemic rats.
abstract: Whether obliteration of glomerular epithelial foot processes and increases in urinary N-acetyl-beta-D-glucosaminidase (NAG) activity are the consequence or the cause of proteinuria after administrations of the aminonucleoside of puromycin was examined using Nagase analbuminemic rats. The administration of puromycin aminonucleoside to Nagase analbuminemic rats did not induce proteinuria. However, the increase in urinary NAG activity and the degree of abnormality of foot processes in the glomerular cells were similar to those in control Sprague-Dawley rats. These findings suggest that NAG excretion and the morphological alterations of epithelial cells in nephrosis are not the consequence of massive proteinuria.
authors.affiliation: Research Institute of Oriental Medicine, Kinki University, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Abe
authors.forename: T
authors.initials: T
authors.lastname: Shibuya
authors.forename: S
authors.initials: S
authors.lastname: Odashima
authors.forename: S
authors.initials: S
authors.lastname: Arichi
authors.forename: S
authors.initials: S
authors.lastname: Nagase
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000818:Animals; D005260:Female; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D009401:Nephrosis / Q000139:chemically induced / Q000473:pathology*; D009404:Nephrotic Syndrome / Q000139:chemically induced / Q000473:pathology; D011507:Proteinuria; D011692:Puromycin Aminonucleoside; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D012709:Serum Albumin / Q000172:deficiency*
chemical_list: D012709:Serum Albumin; D011692:Puromycin Aminonucleoside; D000118:Acetylglucosaminidase