title: [Nuclear medicine diagnosis of Alzheimer type dementia].
abstract: Eleven patients with Alzheimer type dementia were investigated by single-photon-emission computed tomography (SPECT) using 99mTc-hexamethylpropylene-aminoxim (HM-PAO). Nine had a typical, symmetrically reduced enrichment in the parieto-temporo-occipital area. In three of these nine patients a similar pattern was recorded additionally in the frontal, in the remaining two in the temporal or parietal region. In a semi-quantitative evaluation radioactivity concentrations in the cerebrum and cerebellum were compared. It demonstrated that there was in relation to the cerebellum a reduced concentration in seven of the eight studied cerebral regions. The relative blood flow of the parieto-temporo-occipital region was most markedly affected and in patients with Alzheimer type dementia was reduced by 25% below that of normal subjects. The results indicate that cerebral SPECT with HM-PAO is a reasonable method of investigation to confirm the diagnosis of "Alzheimer type dementia" and exclude other cerebral disease, especially if pathognomonic findings are to be obtained.
authors.affiliation: Institut für Klinische und Experimentelle Nuklearmedizin, Universität Bonn.
authors.forename: F
authors.initials: F
authors.lastname: Grünwald
authors.forename: K
authors.initials: K
authors.lastname: Broich
authors.forename: A
authors.initials: A
authors.lastname: Hartmann
authors.forename: S
authors.initials: S
authors.lastname: Adam
authors.forename: R
authors.initials: R
authors.lastname: Erkwoh
authors.forename: A
authors.initials: A
authors.lastname: Bockisch
authors.forename: S
authors.initials: S
authors.lastname: Frede
authors.forename: A
authors.initials: A
authors.lastname: Hotze
authors.forename: K
authors.initials: K
authors.lastname: Reichmann
authors.forename: H J
authors.initials: HJ
authors.lastname: Biersack
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis*; D001921:Brain / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D003937:Diagnosis, Differential; D006801:Humans; D008875:Middle Aged; D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime
vernacular_title: Nuklearmedizinische Diagnostik der Demenz vom Alzheimer-Typ.