Central action of sanumgerman administered orally in mice.
The behavioral and biochemical studies showed that daily oral administration of sanumgerman (340 mg/kg, i.e. 1/5 LD50) for 3 days exerted a depressive influence on the central nervous system of the mouse. The mechanism of this action could be related to an inhibition of catecholaminergic and of serotoninergic central system activities.
Kleinrok
Z
Z
Department of Pharmacology, School of Medicine, Lublin.
Lekim
D
D
Jagiełło-Wójtowicz
E
E
D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D005857:Germanium / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000494:pharmacology* / Q000633:toxicity
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D005857:Germanium; C050437:sanumgerman