title: Clinical and laboratory features of South American rattlesnake (Crotalus durissus terrificus) envenomation in children.
abstract: The venom of the South American rattlesnake Crotalus durissus terrificus was first reported to have mainly haemolytic and neurotoxic physiopathological activities. Later studies demonstrated the systemic myotoxic action of the venom, characterized by the release of myoglobin from damaged skeletal muscle into serum and urine, and a recent report ruled out the presence of intravascular haemolysis in 3 patients, one child and 2 adults. The present paper describes the clinical-laboratory evolution of 10 children bitten by C. durissus terrificus; 2 developed acute renal failure and one died. The myotoxic activity of the venom was evaluated by measuring serum lactic dehydrogenase, creatine kinase and aspartate aminotransferase, by detection of myoglobin in serum and urine, and by muscle biopsy. Haemolytic activity was evaluated by serial measurements of serum haemoglobin and haptoglobin and by detection of urine haemoglobin. We conclude that the signs and symptoms exhibited by patients bitten by C. durissus terrificus are due only to the myotoxic and neurotoxic action of the venom. The only patients with major morbidity were those who initially received subcutaneous antivenin and did not receive definitive antivenin therapy until later.
authors.affiliation: Department of Pediatrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
authors.forename: P
authors.initials: P
authors.lastname: Cupo
authors.forename: M M
authors.initials: MM
authors.lastname: Azevedo-Marques
authors.forename: S E
authors.initials: SE
authors.lastname: Hering
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D001219:Aspartate Aminotransferases / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood; D003435:Crotalid Venoms; D006242:Haptoglobins / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D009132:Muscles / Q000473:pathology; D009211:Myoglobin / Q000378:metabolism; D012909:Snake Bites / Q000150:complications* / Q000473:pathology; D013997:Time Factors
chemical_list: D003435:Crotalid Venoms; D006242:Haptoglobins; D006454:Hemoglobins; D009211:Myoglobin; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase