[Hydrolysis by plasma cholinesterase of complex adamantyl-containing esters].
The kinetics of cholinesterase enzymatic hydrolysis of carboxylic acid adamantyl derivatives was studied in vitro. The maximal rate of enzymatic hydrolysis in the series of bis-esters was shown to increase on elongation of the distance between ester groups. The maximal hydrolysis rate in the series of bis- and mono-esters decreases on elongation of the distance between ester group and quaternary nitrogen atom. The addition of adamantyl radical to the alcohol part of the molecule of bis- and mono-esters prevents the hydrolysis. The addition of lipophilic radicals to the cationic group of derivatives of mono- and dicarboxylic acids exerts a greater effect on the maximal hydrolysis rate in monoesters than in bis-esters.
Igumnova
N D
ND
Lemina
E Iu
EIu
Bitiukova
I I
II
Klimova
N V
NV
Skoldinov
A P
AP
D000818:Animals; D002264:Carboxylic Acids / Q000493:pharmacokinetics*; D002802:Cholinesterases / Q000097:blood*; D003998:Dicarboxylic Acids / Q000493:pharmacokinetics*; D006736:Horses; D006868:Hydrolysis; D066298:In Vitro Techniques; D013329:Structure-Activity Relationship
D002264:Carboxylic Acids; D003998:Dicarboxylic Acids; D002802:Cholinesterases
Issledovanie gidroliza kholinésterazoĭ plazmy adamantilsoderzhashchikh slozhnykh éfirov.