Study on pinocytosis and antigen presentation by murine peritoneal macrophages to T cells in vitro after cisplatin treatment.
Macrophage monolayers showed significantly increased rate of pinocytosis on incubation with cisplatin (10 micrograms/ml). Further, the rate of pinocytosis was compared with macrophages treated with LPS (10 micrograms/ml). Cisplatin treated macrophages also showed enhanced capacity of antigen presentation to T cells in vitro. The antigen presenting capacity of cisplatin treated macrophages was compared with the antigen presenting capacity to LPS treated macrophages.
Sodhi
A
A
Department of Zoology, Banaras Hindu University, Varanasi, India.
Gupta
P
P
D000818:Animals; D000941:Antigens / Q000276:immunology*; D002478:Cells, Cultured; D002945:Cisplatin / Q000494:pharmacology*; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010537:Peritoneum / Q000276:immunology*; D010873:Pinocytosis / Q000187:drug effects*
D000941:Antigens; D002945:Cisplatin