Spontaneous familial systemic lupus erythematosus in a canine breeding colony.
A colony of German shepherd dogs was studied in which a high proportion of antinuclear antibody (ANAb) carriers and dogs with systemic lupus erythematosus (SLE)-like signs were found. The titre of serum thymulin and the percentage of circulating T lymphocytes were both low. The incidence of disease decreased down the generations through the introduction of outside sires, thus suggesting a genetic origin for the disease.
Hubert
B
B
Ecole Nationale Vétérinaire de Lyon, Marcy L'Etoile, France.
Teichner
M
M
Fournel
C
C
Monier
J C
JC
D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood; D001947:Breeding; D004285:Dogs; D007596:Joints / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000662:veterinary; D008231:Lymphopenia / Q000097:blood; D012867:Skin / Q000503:physiopathology; D013601:T-Lymphocytes / Q000503:physiopathology; D013921:Thrombocytopenia / Q000097:blood; D013935:Thymic Factor, Circulating / Q000032:analysis
D000974:Antibodies, Antinuclear; D013935:Thymic Factor, Circulating