The effect of retinoids on the migration of Tenon's capsule fibroblasts.
The effect of the retinoids, retinol and all-trans acid, was assessed in vitro on the migration of rabbit Tenon's capsule fibroblasts, with a view to using these drugs as inhibitors of fibrosis in relation to trabeculectomies. No inhibition of fibroblast migration was demonstrated, and in fact retinol significantly enhanced both the random and directed migration of these cells (p less than 0.001 and p less than 0.01, respectively). This study emphasises the importance of using appropriate cells when investigating the effects of drugs on wound healing.
Joseph
J P
JP
Institute of Ophthalmology, London.
Grierson
I
I
Hitchings
R A
RA
D000818:Animals; D002633:Chemotaxis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005123:Eye / Q000166:cytology*; D005347:Fibroblasts / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D014212:Tretinoin / Q000494:pharmacology*; D014801:Vitamin A / Q000494:pharmacology*
D014801:Vitamin A; D014212:Tretinoin