Bambuterol, a bronchodilator prodrug with sustained action, enhances delivery of active drug to the lung.
As exemplified with bambuterol, a bronchodilator prodrug with sustained action, increased therapeutic selectivity can be obtained as a result of altered tissue distribution and pharmacokinetics rather than of increased beta 2-adrenoceptor selectivity.
Svensson
L A
LA
Research and Development Department, AB DRACO, Lund, Sweden.
D000818:Animals; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D011355:Prodrugs / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013726:Terbutaline / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D014018:Tissue Distribution
D001993:Bronchodilator Agents; D011355:Prodrugs; D013726:Terbutaline; C047766:bambuterol