[Effects of malnutrition in utero and during lactation on various parameters of the small intestine in rats].
Short and long term effects of malnutrition on the small intestine, applied to the rat in uterus and lactation, have been studied. Malnutrition was induced by feeding the pregnant rats on 14 g daily during pregnancy and 21 g during lactation. In the pups (0, 15, 30, 90 and 150 days old), body weight and wet and dry weight and length of small intestine were measured. At 2.5-3 months of age, food transformation efficiency was studied, at 3 and 5 months of age in vivo intestinal absorption of D-glucose (11 mM) was measured. The results indicate a significant decrease in intestinal morphometric parameters in malnourished animals from birth to the age of 5 months. At the age of 3 months both food transformation efficiency and in vivo absorption of glucose were significantly higher in early undernourished animals, whereas at 5 months, glucose absorption was significantly higher in control. It can thus be concluded that early malnutrition altered the small intestine development and functionality and that total recovery did not occur after 4 months on a normal diet.
Gutiérrez
J M
JM
Departamento de Biología Funcional (Area de Fisiología), Facultad de Medicina, Universidad de Oviedo, España.
Alvarez-Ordás
I
I
Fernández
S
S
Marín
B
B
Menéndez-Patterson
A
A
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001835:Body Weight; D005314:Embryonic and Fetal Development; D005260:Female; D005947:Glucose / Q000378:metabolism; D007421:Intestine, Small / Q000254:growth & development*; D007774:Lactation; D009929:Organ Size; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D005947:Glucose
Efectos de la malnutrición in utero y en la lactancia sobre diversos parámetros del intestino delgado de rata.