Prostaglandins and altered diabetic vasoregulation.
In previous studies an enhanced tendency to vasconstriction could be demonstrated in special regions, first of all in the coronary arterial bed of the diabetic vasculature. Analysing the role of prostaglandins in this phenomenon, the present work demonstrates that in vivo the dose-dependent decrease in the conductivity of the coronary arterial bed induced by PGF2 alpha (3, 6, 12, 24, 48 nmol/kg) administration in alloxan- (560 mumol/kg) diabetic dogs (n = 6) proved to be more expressed after indomethacin (10 mumol/kg) treatment compared with metabolically healthy (n = 6) animals. In the presence of indomethacin (3 mumol/l) PGF2 alpha (1, 3, 10, 30 mumol/l) evoked also considerably higher vasoconstriction in the isolated coronary rings of the diabetic dogs in comparison to the metabolically healthy state. The data are referring to the contribution of an altered prostaglandin biosynthesis in the diabetic coronaries to their increased tendency to vasoconstriction induced by PGF2 alpha.
Koltai
M Z
MZ
National Institute of Cardiology, Department of Pharmacodynamics, Semmelweis Medical School, Budapest, Hungary.
Hadhazy
P
P
Köszeghy
A
A
Ballagi-Pordany
G
G
Pogatsa
G
G
D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D015237:Dinoprost / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D012016:Reference Values; D014661:Vasoconstriction / Q000187:drug effects*
D015237:Dinoprost; D007213:Indomethacin