title: Plasma immunoreactive-trypsin(ogen) levels during development.
abstract: We previously showed that the uptake of intact trypsin from the intestine of suckling animals was greater than that of weaned animals. To extend these studies, we measured plasma cationic immunoreactive-trypsin(ogen) in human subjects aged 3 days to 43 years. In agreement with the observation of other investigators, we found that the concentration of cationic immunoreactive-trypsin(ogen) was significantly increased in 3-day-old infants compared with other age groups. None of the cationic immunoreactive-trypsin in adult samples was bound to alpha 1-antitrypsin, whereas 28% of cationic immunoreactive-trypsin in infant samples was bound to alpha 1-anti-trypsin.
authors.affiliation: Department of Pediatric Gastroenterology, Schneider Children's Hospital, State University of New York at Stony Brook, New Hyde Park 11042.
authors.forename: J J
authors.initials: JJ
authors.lastname: Levine
authors.forename: J N
authors.initials: JN
authors.lastname: Udall
authors.forename: K J
authors.initials: KJ
authors.lastname: Bloch
authors.forename: D G
authors.initials: DG
authors.lastname: Hanson
authors.forename: B C
authors.initials: BC
authors.lastname: James
authors.forename: W A
authors.initials: WA
authors.lastname: Walker
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000097:blood*; D011232:Chemical Precipitation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000097:blood*; D008297:Male; D011863:Radioimmunoassay; D014357:Trypsin / Q000097:blood*; D014362:Trypsinogen / Q000097:blood*; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D000515:alpha 1-Antitrypsin; D014362:Trypsinogen; D014357:Trypsin