[EGF receptors (epidermal growth factor) and steroid receptors in human meningioma].
Epidermal growth factor receptor (EGF-R) were assayed by 125I-EGF binding in 28 surgical samples of human meningiomas. High affinity EGF-R were found in 26/28 tumors (92 p. 100) at concentrations ranging from 20 to 410 femtomoles per mg of membrane protein (fmol/mg prot. mb.). In 18/26 cases (64 p. 100), the EGF-R concentration was between 95 and 230 fmol/mg prot. mb. No relationship was found between the EGF-R level and the site or histopathology of the tumor. The only noticeable observations were the low levels of EGF-R in the 3 anaplasic meningiomas as compared to the whole population and the undetectable level of EGF-R in the angiomatous tumors. In addition, no correlation was found between EGF-R levels and the hormonal status of the patients, nor between EGF-R levels and the intratumoral concentration of progesterone receptors assayed simultaneously. The biological relevance of EGF-R in meningioma is discussed in this context.
Grimaux
M
M
Laboratoire de Radiopathologie, Institut Curie, Paris.
Magdelenat
H
H
Poisson
M
M
Chamouard
J M
JM
Barritault
D
D
Foncin
J F
JF
Philippon
J
J
D000328:Adult; D000368:Aged; D004815:Epidermal Growth Factor / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008579:Meningioma / Q000378:metabolism* / Q000473:pathology; D008593:Menopause; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism*
D007457:Iodine Radioisotopes; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid; D004815:Epidermal Growth Factor; D066246:ErbB Receptors
Récepteurs d'EGF (epidermal growth factor) et de stéroïdes dans les méningiomes humains.