title: [In vitro susceptibilities of clinical isolates of Staphylococcus aureus].
abstract: In vitro susceptibilities of 350 strains of Staphylococcus aureus to ampicillin (ABPC), methicillin (DMPPC), cloxacillin (MCIPC), cefazolin (CEZ), cefmetazole (CMZ), cefmenoxime (CMX), latamoxef (LMOX) and 5 non-beta-lactam antimicrobial agents were determined according to the standard method of Japan Society of Chemotherapy. Frequencies of the appearance of resistant organisms (MIC greater than or equal to 12.5 micrograms/ml) to beta-lactam antibiotics were 45% for ABPC, 27% for DMPPC, 11% for MCIPC, 24% for CEZ, 15% for CMZ, 36% for CMX and 51% for LMOX. To non-beta-lactam antimicrobial agents, resistant strains appeared at 31% to gentamicin, 15% to amikacin, 0.6% to minocycline (MINO), 1% to norfloxacin (NFLX) and 65% to fosfomycin (FOM). More than 80% of DMPPC-resistant strains were also resistant to LMOX, CMX, ABPC, FOM, and CEZ, but most of those were susceptible to MINO and NFLX. Incidence of DMPPC-CEZ resistant S. aureus was 23% of the 350 strains tested. As stated above, multiply resistant strains of S. aureus are present throughout different hospitals in Okinawa.
authors.affiliation: Department of Clinical Pathology, School of Health Science, Faculty of Medicine, University of Ryukyus.
authors.forename: J
authors.initials: J
authors.lastname: Igari
authors.forename: K
authors.initials: K
authors.lastname: Shimoji
authors.forename: N
authors.initials: N
authors.lastname: Uezu
authors.forename: I
authors.initials: I
authors.lastname: Nakasone
authors.forename: K
authors.initials: K
authors.lastname: Taira
authors.forename: R
authors.initials: R
authors.lastname: Kakazu
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002437:Cefazolin / Q000494:pharmacology; D015281:Cefmenoxime / Q000494:pharmacology; D015311:Cefmetazole / Q000494:pharmacology; D003023:Cloxacillin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D008712:Methicillin / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D015311:Cefmetazole; D000667:Ampicillin; D002437:Cefazolin; D015281:Cefmenoxime; D003023:Cloxacillin; D008712:Methicillin