[Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody].
It has been over 15 years since Eisen first suggested that immunoglobulin idiotype could serve as a tumor-specific antigen. Over 10 years ago, Stevenson pointed out that B cell malignancies would be ideal targets for the idiotype-directed immune responses because these tumors retain the idiotype molecule on their cell surface rather than secreting it. Since that time a number of studies with animal models have shown that either passive or active immune manipulation directed at cell surface idiotypic determinants could have therapeutic effects on B cell malignancies. In this paper we will summarize and update the results of our clinical trials with anti-idiotype antibodies in patients with B cell malignancies. The results indicate that anti-idiotype antibodies can have profound effects on tumors, causing regressions in the majority of the patients treated. In addition, these studies have revealed that human B cell tumors are idiotypically heterogeneous due to extensive V-region somatic mutation.
Kon
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Dept. of Pathology 1, Sapporo Medical College.
D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000008:administration & dosage; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D008223:Lymphoma / Q000628:therapy*
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes