title: Biodegradable PEO/PLA block copolymers.
abstract: Poly(ether ester) block copolymers based on polyethylene oxide (PEO) and polylactic acid (PLA) segments were synthesized and characterized, with the aim of developing a new family of bioadsorbable polymers. The materials developed were tailored to meet various mechanical and degradation requirements, and overcome the limitations of the few existing biodegradable polymers. The copolymeric matrices were characterized by means of infrared spectroscopy, differential scanning calorimetry, and nuclear magnetic resonance spectroscopy. The composition of the copolymers synthesized varied between 20 and 84 mol% lactic acid, with PEO chains in the 600-6000 molecular weight range. The solubility properties of the copolymers in a series of organic solvents are described. The equilibrium water content and the water contact angle of various matrices were determined and related to their composition and structure. The incorporation of PEO into the chain yielded highly hydrophilic materials, with equilibrium water contents higher than 60%. Stress/strain curves are presented.
authors.affiliation: Casali Institute of Applied Chemistry, School of Applied Science and Technology, Hebrew University of Jerusalem, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Cohn
authors.forename: H
authors.initials: H
authors.lastname: Younes
mesh_terms: D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D007773:Lactates / Q000138:chemical synthesis; D009682:Magnetic Resonance Spectroscopy; D011092:Polyethylene Glycols / Q000138:chemical synthesis; D011108:Polymers / Q000138:chemical synthesis; D013055:Spectrophotometry, Infrared; D013314:Stress, Mechanical
chemical_list: D001672:Biocompatible Materials; D007773:Lactates; D011108:Polymers; C058523:polyethylene oxide-polylactic acid block copolymer; D011092:Polyethylene Glycols