ADDH and methylphenidate responders: effects on behavior controlled by complex reinforcement schedules.
One of the most effective treatments for children with Attention Deficit Disorder with Hyperactivity (ADDH) has been the prescription of methylphenidate (MPH). While laboratory-based evidence indicates that MPH effects may be rate-dependent, little is known about changes evinced in operant behavior controlled by complex reinforcement schedules. The present study examined the effects of several doses of MPH on the operant key-pressing behavior of 20 children with ADDH who were favorable responders to the drug. Following a drug-free training period, each child performed the task across all doses in a randomly assigned sequence under double-blind placebo control conditions. Rate-dependent effects were found for both high- and low-rate reinforcement schedules. The strength of these effects varied across dose. These results have implications for the nature of rate-dependent phenomena in humans and investigations of treatment parameters in the pharmacotherapy of children with ADDH.
DuPaul
G J
GJ
Department of Psychiatry, University of Massachusetts Medical Center, Worcester 01655.
Rapport
M D
MD
Vyse
S A
SA
D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D002648:Child; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D012055:Reinforcement Schedule
D008774:Methylphenidate