Possible involvement of queuine in oxidative metabolism.
The possibility that the base, queuine, or the queuine family of tRNAs may play a role in oxidative metabolism has been investigated. (i) The enzymatic insertion of queuine into tRNA requires oxygen. This is true for both the mammalian and bacterial enzyme. (ii) (q-) LM cells (murine fibroblast line) grown in culture had 53% less of the manganese-containing superoxide dismutase than (q+) cells. (iii) There was less thiobarbituric-acid-reactive material in queuine-deficient mouse liver and kidney than in (q+) liver and kidney.
Szabo
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University of Tennessee, College of Veterinary Medicine, Knoxville.
Nishimura
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Farkas
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WR
D000332:Aerobiosis; D000693:Anaerobiosis; D000818:Animals; D005856:Germ-Free Life; D006147:Guanine / Q000031:analogs & derivatives* / Q000378:metabolism; D050356:Lipid Metabolism; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D010084:Oxidation-Reduction / Q000187:drug effects; D010100:Oxygen / Q000494:pharmacology*; D010430:Pentosyltransferases / Q000378:metabolism; D012345:RNA, Transfer, Amino Acid-Specific / Q000378:metabolism; D013858:Thiobarbiturates / Q000378:metabolism
D012345:RNA, Transfer, Amino Acid-Specific; D013858:Thiobarbiturates; D008315:Malondialdehyde; D006147:Guanine; C019549:queuine; D010430:Pentosyltransferases; C020837:queuine tRNA-ribosyltransferase; C029684:thiobarbituric acid; D010100:Oxygen