Structure and carcinogenicity of dibenzo(c,g)carbazole derivatives.
The carcinogenicity of several groups of carcinogens is evoked with particular reference to Dibenzo(c,g)carbazole derivatives. The activity of these derivatives is discussed with respect to their species and organ specificity. The enzymatic equipment is decisive as to whether the compounds formed can react with DNA or are simply detoxified and eliminated. All these carcinogens are complete carcinogens, i.e. they have the property of both initiation and promotion.
Szafarz
D
D
Institut Curie-Biologie, Centre Universitaire, Orsay, France.
Périn
F
F
Valéro
D
D
Zajdela
F
F
D000818:Animals; D002227:Carbazoles / Q000378:metabolism / Q000633:toxicity*; D002273:Carcinogens / Q000145:classification; D004247:DNA / Q000378:metabolism; D006498:Hepatectomy; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D009928:Organ Specificity; D011506:Proteins / Q000378:metabolism; D013045:Species Specificity
D002227:Carbazoles; D002273:Carcinogens; D011506:Proteins; D004247:DNA; C013478:7H-dibenzo(c,g)carbazole