Effect of minaprine on neuronal activity in the brain stem reticular formation of the rat.
Extracellular single unit recordings were made in the brain stem reticular formation (RF) of urethane-anesthetized rats. Minaprine (cumulative i.v. dose of 10 mg/kg, given as 2.5, 2.5 and 5 mg/kg) has no significant effects on the RF neurons. Pentobarbital (10 mg/kg, i.v.) and scopolamine (5 mg/kg, i.v.) reduced the firing rate of the RF neurons. Minaprine (cumulative i.v. dose of 10 mg/kg, given as 2.5, 2.5 and 5 mg/kg) reversed the effects of pentobarbital and scopolamine. These observations indicate that minaprine has an ameliorating effect on the drug-induced depression of neuronal activity in the RF.
Okuyama
S
S
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Aihara
H
H
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001933:Brain Stem / Q000166:cytology / Q000187:drug effects; D008297:Male; D009474:Neurons / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology; D011724:Pyridazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012154:Reticular Formation / Q000187:drug effects*; D012601:Scopolamine / Q000494:pharmacology
D000928:Antidepressive Agents; D011724:Pyridazines; C006149:minaprine; D012601:Scopolamine; D010424:Pentobarbital