Human T cell specific proteinase (HuTSP) is encoded by the T cell and natural killer cell specific human Hanukah factor (HuHF) gene.
HuTSP, a serine proteinase which is specifically associated with activated t lymphocytes, was purified to homogeneity and characterized. N-terminal amino acid sequencing revealed identity with a sequence predicted from the human Hanukah factor (HF) gene, which was isolated from a human T cell cDNA library. The dimeric structure of HuTSP, together with its extensive sequence homologies with the murine T cell specific proteinase, MTSP-1, suggests phylogenetic conservation of this serine proteinase family.
Fruth
U
U
Max-Planck-Institut für Immunbiologie, Freiburg, FRG.
Eckerskorn
C
C
Lottspeich
F
F
Kramer
M D
MD
Prester
M
M
Simon
M M
MM
D000595:Amino Acid Sequence; D002460:Cell Line; D005796:Genes; D053804:Granzymes; D006801:Humans; D007694:Killer Cells, Natural / Q000201:enzymology*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D012697:Serine Endopeptidases / Q000235:genetics* / Q000302:isolation & purification; D013601:T-Lymphocytes / Q000201:enzymology*
D053804:Granzymes; D012697:Serine Endopeptidases; C509212:GZMA protein, human