An antibody in the CSF of Parkinson's disease patients disappears following adrenal medulla transplantation.
CSF from Parkinson's disease (PD) patients undergoing autologous transplantation of adrenal medulla tissue into their lateral ventricle was examined for the presence of IgG. CSF from 6 of 7 patients incubated with rat brain tissue reacted immunocytochemically to neuronal cell bodies in the substantia nigra and ventral tegmental region. This reactivity gradually disappeared in the months following transplantation. Five of 6 CSF samples from non-transplanted PD patients also produced this immunocytochemical reactivity whereas 26 non-PD samples were immunonegative. Possible implications to the transplant procedure are discussed.
McRae-Degueurce
A
A
Department of Neurological Sciences, Rush-Presbyterian St. Lukes Medical College, Chicago, IL.
Klawans
H L
HL
Penn
R D
RD
Dahlstrom
A
A
Tanner
C M
CM
Goetz
C G
CG
Carvey
P M
PM
D000313:Adrenal Medulla / Q000637:transplantation*; D000818:Animals; D002552:Cerebral Ventricles / Q000601:surgery*; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D009474:Neurons / Q000276:immunology; D010300:Parkinson Disease / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000601:surgery; D051381:Rats; D013378:Substantia Nigra / Q000276:immunology; D013681:Tegmentum Mesencephali / Q000276:immunology; D014182:Transplantation, Autologous
D007074:Immunoglobulin G