Rat ovarian prostaglandin levels and ovulation as indicators of the strength of non-steroidal anti-inflammatory drugs.
Immature Wistar rats were treated with pregnant mare's serum gonadotropin and human chorionic gonadotropin to induce ovulation. The non-steroidal anti-inflammatory drugs indomethacin, diclofenac, flurbiprofen, and phenylbutazone inhibited both the ovulation rate and the normal increase in ovarian prostaglandin E during ovulation. Tolmetin, ibuprofen, and aspirin did not have any significant effect. There was a significant correlation between the ovulation rate and the level of ovarian prostaglandin E following treatment with these drugs. When indomethacin was given in graded doses, there was also a correlation between ovulation rate and the dose-dependent inhibition of ovarian prostaglandin E.
Espey
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Biology Department, Trinity University, San Antonio, Texas 78284.
Kohda
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H
Mori
T
T
Okamura
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H
D000818:Animals; D000831:Animals, Newborn; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006064:Gonadotropins, Equine / Q000008:administration & dosage; D066298:In Vitro Techniques; D010053:Ovary / Q000032:analysis* / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects*; D011458:Prostaglandins E / Q000032:analysis* / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006064:Gonadotropins, Equine; D011458:Prostaglandins E