Alterations of acyl-neuraminic acids on T-lymphocytes in cases of melanoma.
Content and distribution of the different sialic acids on human lymphocytes, isolated from 7-10 ml of fresh human blood, were determined using microanalytical methods, such as HPLC and a colorimetric test. Comparison of the data of patients with melanoma with those of healthy persons shows an evident increase of the sialic acid content combined with a shift of the sialic acid distribution to higher O-acetylated derivatives.
Holzhauser
R
R
Universität des Saarlandes, Biochemie.
Faillard
H
H
Klose
W
W
Huber
W
W
Stickl
H
H
Landthaler
M
M
D002851:Chromatography, High Pressure Liquid; D003124:Colorimetry; D006801:Humans; D008545:Melanoma / Q000276:immunology*; D012794:Sialic Acids / Q000378:metabolism*; D012878:Skin Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D012794:Sialic Acids