title: The somatosensory evoked potential predicts neurologic deficits and serotonergic pathochemistry after spinal distraction injury in experimental scoliosis.
abstract: The validity of the somatosensory evoked potential as an intraoperative spinal cord monitor was evaluated in an experimental model of scoliosis in the rat and a Harrington distraction model of injury. Under these conditions, it was found that any change in latency or amplitude of the major negative wave above a certain level was a significant predictor of an adverse neurologic outcome. Changes in latency of 4% or greater and changes in amplitude of 50% or greater were unequivocal indicators of spinal cord injury. Postmortem analyses of the spinal neurotransmitter serotonin revealed that apparent false-positive results of the SEP were, in fact, true-positive results.
authors.affiliation: Department of Research, Alfred I. duPont Institute, Wilmington, Delaware.
authors.forename: S K
authors.initials: SK
authors.lastname: Salzman
authors.forename: K W
authors.initials: KW
authors.lastname: Dabney
authors.forename: A A
authors.initials: AA
authors.lastname: Mendez
authors.forename: J T
authors.initials: JT
authors.lastname: Beauchamp
authors.forename: J C
authors.initials: JC
authors.lastname: Daley
authors.forename: G M
authors.initials: GM
authors.lastname: Freeman
authors.forename: A
authors.initials: A
authors.lastname: Fonseca
authors.forename: E B
authors.initials: EB
authors.lastname: Ingersoll
authors.forename: A L
authors.initials: AL
authors.lastname: Beckman
authors.forename: W P
authors.initials: WP
authors.lastname: Bunnell
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005073:Evoked Potentials, Somatosensory; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time; D012600:Scoliosis / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D012701:Serotonin / Q000378:metabolism*
chemical_list: D012701:Serotonin