[The pharmacokinetics of light-protective agents by photoacoustic spectroscopy].
We report on in vivo investigations by photoacoustic spectroscopy on the liberation and horny-layer penetration of UV-absorbing drugs from topically applied vehicle films. This spectroscopic technique can be used to determine the absorption of light in the skin with a depth resolution adequate for the 12-microns-thick horny layer and to gain information on temporal variations in the concentration profile of drug penetrating into the horny layer. Experimental results are presented for the UV-absorbing drugs Uvinul T 150 and P 25 applied to the skin in different vehicles. The results are discussed with reference to model calculations demonstrating the influence of different rate-determining steps on temporal variations in concentration profiles.
Kölmel
K F
KF
Universität-Hautklinik Göttingen, Abteilung Dermatologie und Venerologie.
Sennhenn
B
B
Rohr
M
M
Giese
K
K
D004305:Dose-Response Relationship, Drug; D006801:Humans; D009930:Organic Chemicals; D012815:Signal Processing, Computer-Assisted; D012869:Skin Absorption; D013054:Spectrophotometry, Atomic / Q000295:instrumentation*; D013473:Sunscreening Agents / Q000493:pharmacokinetics*
D009930:Organic Chemicals; D013473:Sunscreening Agents; C059256:Uvinul T 150
Untersuchungen zur Pharmakokinetik von Lichtschutzsubstanzen durch photoakustische Spektroskopie.