A mapped set of DNA markers for human chromosome 15.
A primary genetic linkage map for human chromosome 15 has been constructed from 16 arbitrary DNA markers genotyped in 59 large reference families. The map spans a genetic distance of 146 cM in males and 187 cM in females. The ratio of female/male genetic distance was approximately 2.1 overall within the region of the chromosome covered by our map, but three segments showed a significant male excess in recombination frequency. A subset of seven of the linked markers would be enough to detect linkage of a genetic defect within the mapped region of chromosome 15, if at least 48 phase-known meioses in affected families were available for analysis.
Nakamura
Y
Y
Howard Hughes Medical Institute, University of Utah Medical School, Salt Lake City 84132.
Lathrop
M
M
O'Connell
P
P
Leppert
M
M
Lalouel
J M
JM
White
R
R
D000483:Alleles; D002460:Cell Line; D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D004247:DNA / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers / Q000032:analysis; D006579:Heterozygote; D006801:Humans; D008297:Male; D010957:Plasmids; D014589:Utah
D005819:Genetic Markers; D004247:DNA