Shift in phenotype of acute T-lymphocytic leukemia to eosinophilic leukemia: a case report.
Acute T-lymphocytic leukemia diagnosed in a 14-year old boy on the basis of typical cell morphology, as well as by membrane antigen analysis with monoclonal antibodies, shifted to the phenotype of an acute eosinophilic leukemia 5 months after the initiation of chemotherapy. The transformation was evident by a change in morphology of cells derived from bone marrow aspirates, by cytochemistry and by a shift in the membrane antigen pattern.
Preis
P P
PP
2nd Department of Medicine, Vienna University Hospital.
Zielinski
C C
CC
Linkesch
W
W
Bettelheim
P
P
Radaskiewicz
T
T
Pavelka
M
M
Haas
O
O
Aiginger
P
P
D000293:Adolescent; D000954:Antigens, Surface / Q000235:genetics; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D004804:Eosinophils / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000139:chemically induced / Q000235:genetics*; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D010641:Phenotype; D012074:Remission Induction; D013601:T-Lymphocytes / Q000473:pathology
D000954:Antigens, Surface