Pulmonary exchange of solutes during experimental lung lavage in pigs.
Unilateral continuous lung lavage in a nonregenerating system (3,000 ml isotonic cristalloid) was done in 12 pigs for 270 min. The concentration of substances in serum and fluid was measured. Half-time (t1/2) of exchange and permeability constants (P) were determined. In the fluid Na+ decreased significantly (t1/2 = 107 min, P = 7.8 x 10(-7]. Urea increased significantly, reaching serum level after 270 min (t1/2 = 109.1 min, P = 6.18 x 10(-6]. Ca2+ (t1/2 = 36.7 min, P = 4.1 x 10(-7] PO4 = (t1/2 = 173.3 min, P = 1.1 x 10(-7], and creatinine (t1/2 = 55.2 min, P = 6.2 x 10(-7] also increased markedly but did not reach serum level. The adjustment to serum concentration may be prevented by interaction between diffusion, active transport or Donnan's equilibria. K+ increased almost linearly, documented by the long half-time (t1/2 = 7,835.2 min, P = 7.7 x 10(-7] and did not reach serum level. The calculated limit value was higher than the serum level. Active transport systems or influx of K+ from cellular compartments rather than from the serum might be involved in its linear kinetics. Total protein (t1/2 = 61.5 min, P = 2.06 x 10(-9] and albumin (t1/2 = 58.8 min, P = 1.7 x 10(-9] increased initially but levelled far below the serum value. The low P indicates a lack of significant permeation. Initial increase may be due to washout of the epithelial lining fluid compartment. There was minimal transfer of lavage fluid into the organism (10-20 ml/30 min). Serum concentrations were not affected by the lavage.
Juettner
F M
FM
Department of Thoracic and Hyperbaric Surgery, University Medical School of Graz, Austria.
Smolle
J
J
Popper
H
H
Rehak
P
P
Petek
W
W
Friehs
G
G
D000818:Animals; D001693:Biological Transport, Active; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis* / Q000378:metabolism; D003404:Creatinine / Q000032:analysis / Q000097:blood / Q000652:urine; D004058:Diffusion; D004573:Electrolytes / Q000032:analysis* / Q000097:blood; D008168:Lung / Q000378:metabolism*; D009994:Osmolar Concentration; D011506:Proteins / Q000032:analysis; D012964:Sodium / Q000032:analysis / Q000097:blood / Q000652:urine; D013552:Swine; D013997:Time Factors; D014508:Urea / Q000032:analysis / Q000097:blood
D004573:Electrolytes; D011506:Proteins; D014508:Urea; D012964:Sodium; D003404:Creatinine