title: Synthesis and photobiological activity of new N,N-disubstituted 4-amino-3-chloroangelicins.
abstract: The synthesis of a series of new N,N-disubstituted 4-amino-3-chloroangelicins (4-amino-3-chloro-2H-furo[2,3-h]-1-benzopyran-2-ones) starting from N,N-disubstituted (E)-5-aminomethylene-6,7-dihydrobenzo[b]furan-4(5H)-ones is described. Their capacity of inhibiting DNA synthesis in Ehrlich ascites tumor cells by U.V.-A light irradiation as well as their phototoxic activity on guinea-pig skin have been studied and the data computed by probit analysis; the results are discussed in the light of the modifications introduced in the molecular structure.
authors.affiliation: Istituto di Scienze Farmaceutiche, Università di Genova, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Mosti
authors.forename: G
authors.initials: G
authors.lastname: Menozzi
authors.forename: P
authors.initials: P
authors.lastname: Schenone
authors.forename: F
authors.initials: F
authors.lastname: Carlassare
authors.forename: F
authors.initials: F
authors.lastname: Baccichetti
authors.forename: F
authors.initials: F
authors.lastname: Bordin
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D004273:DNA, Neoplasm / Q000096:biosynthesis; D011564:Furocoumarins / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D051379:Mice; D010778:Photochemotherapy
chemical_list: D004273:DNA, Neoplasm; D011564:Furocoumarins