Generation of LAK cells depends on the age of LAK cell precursor donors.
Age-related changes in generation of lymphokine-activated killer cells were examined in the experimental system of B10 murine effector cells activated with human recombinant interleukin 2 that were allowed to react with a panel of murine and human target cell lines. The percentage of specific 51Cr release displayed by the LAK cells derived from 6- and 12-month-old donors was consistently lower than that displayed by the 2-month-old mice. However, even the LAK cells from 12-month-old mice still showed a significant cytolytic activity.
Indrová
M
M
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha.
Bubeník
J
J
D000375:Aging; D000818:Animals; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D007376:Interleukin-2 / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D011994:Recombinant Proteins / Q000494:pharmacology
D007376:Interleukin-2; D011994:Recombinant Proteins