Portal hypertension secondary to azathioprine in myasthenia gravis.
A 52 year old man with myasthenia gravis and normal liver function was treated with neostigmine, prednisolone and azathioprine. Three years after starting azathioprine he developed clinical evidence of portal hypertension. A liver biopsy showed nodular regenerative hyperplasia (NRH). The development of NRH following azathioprine treatment in a patient with myasthenia gravis strengthens the case for a causal role of azathioprine in producing NRH and portal hypertension.
Fonseca
V
V
Royal Free Hospital, London, UK.
Havard
C W
CW
D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006975:Hypertension, Portal / Q000139:chemically induced* / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000188:drug therapy* / Q000473:pathology
D001379:Azathioprine