Structural requirements of endotoxic lipopolysaccharides and bacterial cell walls in induction of interleukin-1.
A variety of compounds, synthetic, semisynthetic or bacterial, which corresponds to structural components of endotoxic lipopolysaccharides (LPS) and bacterial cell wall peptidoglycans were studied for their activity to enhance interleukin-1 (IL-1) production of murine peritoneal macrophages and the ability to activate the complement cascade in fresh adult human serum. Not only bacterial LPS and cell walls or peptidoglycans but also their structural components with appropriate size and structure induced IL-1 production by macrophages and activated the human complement cascade, which may lead to the IL-1 production by monocytes/macrophages.
Takahashi
I
I
Department of Microbiology and Oral Microbiology, Osaka University Dental School, Japan.
Kotani
S
S
Takada
H
H
Shiba
T
T
Kusumoto
S
S
D000818:Animals; D002473:Cell Wall / Q000032:analysis*; D003167:Complement Activation / Q000187:drug effects; D004731:Endotoxins / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D008050:Lipid A / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D010457:Peptidoglycan / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D004731:Endotoxins; D007375:Interleukin-1; D008050:Lipid A; D008070:Lipopolysaccharides; D010457:Peptidoglycan