Studies on cell migration, adenylate cyclase and membrane-coating granules in the buccal epithelium of the zinc-deficient rabbit, including the influence of isoproterenol.
Cell migration was slightly increased; cytochemical reaction deposits of adenylate cyclase and the area density of membrane-coating granules (MCG) were significantly increased. Upon isoproterenol stimulation, the MCG area density was significantly increased, whereas the cell migration rate was unchanged. Thus in zinc deficiency, there may be a simultaneous increase in the production and secretion of MCGs, in adenylate cyclase activity, and in cell migration. The non-significantly increased cell migration rate may not keep pace with the significantly increased cell-production rate, resulting in thickening of the epithelium.
Chen
S Y
SY
Department of Pathology, Temple University School of Medicine, Philadelphia, PA 19140.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D002465:Cell Movement / Q000187:drug effects; D002610:Cheek; D003594:Cytoplasmic Granules / Q000187:drug effects*; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects / Q000201:enzymology; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009061:Mouth Mucosa / Q000166:cytology* / Q000187:drug effects / Q000201:enzymology; D011817:Rabbits; D015032:Zinc / Q000172:deficiency*
D000262:Adenylyl Cyclases; D015032:Zinc; D007545:Isoproterenol