Inhibition by mefloquine of Ca2+ stimulated phospholipid dependent protein kinase from rat spleen.
1. Mefloquine, a phospholipid interacting antimalarial drug, inhibits Ca2+ stimulated phospholipid dependent protein kinase from rat spleen by interfering with the activation process. 2. The type of inhibition was found to be competitive with respect to phosphatidylserine; the apparent Ki-value was determined to be 60 microM.
Agarwal
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A
Bernhard-Nocht-Institut für Schiffs- und Tropenkrankheiten, Hamburg, Federal Republic of Germany.
Walter
R D
RD
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D015767:Mefloquine; D010743:Phospholipids / Q000378:metabolism*; D010761:Phosphorus Radioisotopes; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000201:enzymology*
D010743:Phospholipids; D010761:Phosphorus Radioisotopes; D011804:Quinolines; D011493:Protein Kinase C; D002118:Calcium; D015767:Mefloquine