[Hyposensitization with cross-reacting pollen allergens].
Grass-pollen are one of the most common allergens in pollinosis. Rye-pollen are the most important allergens among cereals-pollen in Germany. Between pollen-allergens, the phenomenon of cross-sensitivity is well-known. In the RAST und RAST-Inhibitionstest the cross-sensitivity between grass-pollen and rye-pollen is well documentated. In the clinic the test and challenge with some grass-pollen ist suitable for the diagnosis and planing of therapy. Therefore, it seems, that therapy with grass-pollen should produce the same results as a treatment with grass- and rye-pollen. We treated 35 patients allergic with poaceae-pollen for 3 years in two different ways: One group we treated only with grass-pollen, the other group we treated with grass- and rye-pollen. Under the therapy we controlled the specific IgE and IgG, the nasal challenge-test and the subjective symptoms by diaries and questionnaires. The specific IgE for phleum pratense and rye-pollen decreased, the specific IgG increased in both groups. There were no differences between the two therapy-groups. In the clinical data-subjective and nasal challenge-the therapeutic effect seemed to be better in the group treated with grass- and rye-pollen.
Karl
S
S
Dermatologische Klinik und Poliklinik der Technischen Universität München.
Rakoski
J
J
D000328:Adult; D000485:Allergens / Q000276:immunology*; D003429:Cross Reactions; D003888:Desensitization, Immunologic / Q000379:methods*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D009299:Nasal Provocation Tests; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*
D000485:Allergens; D007074:Immunoglobulin G; D007073:Immunoglobulin E
Hyposensibilisierung mit kreuzreagierenden Pollenallergenen.