Synthesis and preliminary pharmacological studies on dihydropyrido-1,3,4-triazepinone derivatives.
New 4,5-dihydropyrido-[2,3-e]-1,3,4-triazepin-5-one derivatives (2-9) were synthesized. The preliminary pharmacological tests revealed antinociceptive action of compounds 4-7 and 9 and antianxiety action of compound 4.
Nawojski
A
A
Department of Technology of Drugs, Medical Academy, Wroclaw, Poland.
Liszkiewicz
H
H
Nawrocka
W
W
Wilimowski
M
M
Barczyńska
J
J
Kedzierska
L
L
Wojewódzki
W
W
Rutkowska
M
M
Duś
E
E
Szelag
A
A
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001058:Apomorphine / Q000494:pharmacology; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D012110:Reserpine / Q000037:antagonists & inhibitors; D012702:Serotonin Antagonists / Q000138:chemical synthesis
D000700:Analgesics; D000927:Anticonvulsants; D001381:Azepines; D004095:Dihydropyridines; D012702:Serotonin Antagonists; D012110:Reserpine; D001058:Apomorphine