Interleukin-5 is at 5q31 and is deleted in the 5q- syndrome.
Human interleukin-5 (IL-5) is a selective eosinophilopoietic and eosinophil-activating growth hormone. By in situ hybridization this gene is mapped to chromosome 5q23.3 to 5q32. It is shown to be deleted in two patients with the 5q-syndrome and in one patient previously diagnosed with myelodysplasia whose condition had progressed to acute myeloblastic leukemia. The clustering of other genes involved in hematopoiesis (IL-3, granulocyte-macrophage colony-stimulating factor, feline sarcoma viral oncogene homolog, colony-stimulating factor 1) to the same region as IL-5 suggests a nonrandom localization and raises interesting questions concerning the evolution and regulation of these genes.
Sutherland
G R
GR
Cytogenetics Unit, Adelaide Children's Hospital, Australia.
Baker
E
E
Callen
D F
DF
Campbell
H D
HD
Young
I G
IG
Sanderson
C J
CJ
Garson
O M
OM
Lopez
A F
AF
Vadas
M A
MA
D000368:Aged; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D005260:Female; D006801:Humans; D015848:Interleukin-5; D007378:Interleukins / Q000235:genetics*; D008297:Male; D009693:Nucleic Acid Hybridization; D013577:Syndrome
D015848:Interleukin-5; D007378:Interleukins