title: Synthesis of 7 alpha- and 7 beta-carboxymethyl-9(11)-ene derivatives of estrone and estradiol.
abstract: As part of a search for derivatives designed to conjugate to amino groups, either of a protein carrier for antibody production or of an immobilized side-chain on a polymer for affinity chromatography, functionalized estrone and estradiol analogues were prepared. These modified steroids were obtained via the introduction of a carboxymethyl side-chain at the C-7 alpha and C-7 beta position on an adrenosterone derivative and were then aromatized on the A ring. These new compounds are unsaturated at the C-9 (11) position, which could be useful for a second modification.
authors.affiliation: Laboratoires de Chimie Physique Organique, Biochimie PCEM, U.E.R. Domaine Méditerranéen, Nice, France.
authors.forename: B
authors.initials: B
authors.lastname: Charpentier
authors.forename: A
authors.initials: A
authors.lastname: Dingas
authors.forename: J
authors.initials: J
authors.lastname: Cassan
authors.forename: R
authors.initials: R
authors.lastname: Emiliozzi
authors.forename: D
authors.initials: D
authors.lastname: Duval
mesh_terms: D000736:Androstenes; D055598:Chemical Phenomena; D002621:Chemistry; D004958:Estradiol / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D004970:Estrone / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006241:Haptens / Q000138:chemical synthesis; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009277:Nandrolone; D013739:Testosterone
chemical_list: D000736:Androstenes; D006241:Haptens; D004970:Estrone; D013739:Testosterone; D004958:Estradiol; D009277:Nandrolone; C011657:adrenosterone