[Synthesis and anti-ulcer activity of some new compounds with arylthiomethyl-pyridine structure].
We report the results of the antiulcer activity of some arylthiomethylpyridine compounds. Some of these showed gastroprotective activity against 96% ethanol-induced gastric lesions greater than Omeprazole. However they possess antiulcer properties lower than the reference compound against Indomethacin-induced gastric ulcers.
Evangelista
S
S
Menarini Ricerche, Firenze.
Ghelardoni
M
M
Meli
A
A
Pestellini
V
V
Viti
G
G
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D007213:Indomethacin; D008297:Male; D009853:Omeprazole / Q000627:therapeutic use; D011725:Pyridines / Q000138:chemical synthesis* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D011725:Pyridines; C038402:timoprazole; D009853:Omeprazole; D007213:Indomethacin
Sintesi ed attività antiulcera di alcuni nuovi composti a struttura ariltiometil-piridinica.