Blood and plasma concentrations of butalbital following single oral doses in man.
Blood and plasma concentrations of butalbital (from Fiorinal) were determined in a small group of healthy volunteers after single oral doses of 100 mg of butalbital. Butalbital was quantitated by high-performance liquid chromatography with ultraviolet detection. Typical blood concentrations of butalbital peaked at 2.1 mg/L and declined to 1.5 mg/L at 24 h. The half-lives in blood were between 35 and 87.5 h with a mean of 61 h. Whole blood to plasma ratios were also determined.
Drost
M L
ML
Royal Canadian Mounted Police, Forensic Laboratory, Edmonton, Alberta.
Walter
L
L
D000284:Administration, Oral; D000328:Adult; D001463:Barbiturates / Q000008:administration & dosage / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D012459:Salicylates / Q000097:blood
D001463:Barbiturates; D012459:Salicylates; C004470:butalbital