The contribution of natural killer cells to the allograft response.
The NK cells and the alloimmune CTL recovered from a rejecting sponge graft both possess the surface determinant AGM1. Both systemic and local treatment of sponge-bearing mice with anti-AGM1, results in severe inhibition of NK activity and alloimmune CTL activity recovered from the graft. From this evidence it is tempting to speculate that cells exhibiting the characteristics of NK cells may differentiate into alloimmune CTL.
Hoffman
R A
RA
Department of Surgery, University of Minnesota Hospital, Minneapolis 55455.
Jordan
M L
ML
Ascher
N L
NL
Simmons
R L
RL
D000818:Animals; D000943:Antigens, Differentiation / Q000032:analysis; D003602:Cytotoxicity, Immunologic; D005677:G(M1) Ganglioside; D006028:Glycosphingolipids / Q000032:analysis; D006084:Graft Rejection; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D013997:Time Factors
D000943:Antigens, Differentiation; D006028:Glycosphingolipids; D005677:G(M1) Ganglioside; C018835:asialo GM1 ganglioside