Effects of cytidine analogs on methylation of DNA and retrovirus induction.
Several cytidine analogs with known mutagenic capability were tested for their effects on DNA methylation and on induction of endogenous murine retrovirus. For each of the compounds tested it was found that DNA methylation was inhibited at the same concentrations that were required to induce virus expression. With each compound it was observed that increased dose levels produced an increase in the ability to inhibit methylation and an increase in the ability to induce virus.
Rascati
R J
RJ
Department of Biology, Kennesaw College, Marietta, GA 30061.
D000818:Animals; D002478:Cells, Cultured; D003562:Cytidine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects*; D004261:DNA Replication / Q000187:drug effects; D003839:Deoxyadenosines / Q000378:metabolism; D008715:Methionine / Q000378:metabolism; D008745:Methylation; D051379:Mice; D012190:Retroviridae / Q000235:genetics*; D014779:Virus Replication / Q000187:drug effects
D003839:Deoxyadenosines; D003562:Cytidine; D004247:DNA; D008715:Methionine