[Effect of a 3-hydroxypyridine-class antioxidant on the functional activity of the central nervous system in mice of different age groups].
Characteristics of emotional reactivity, orienting-investigating behaviour and of preservation of conditioned reflex of passive avoidance were used for estimation of the functional activity of animals CNS and also of psychotropic effect of antioxidant 2-ethyl-6-methyl-3-oxypyridine (3-OP) on mice of different age. Studies were carried out on white outbred young (3 months) and elderly (15 months) male mice. Different character was observed of the emotional reactions of different age mice to aversive stimuli and to the open field conditions. Differences were noted of psychotropic effects of 3-OP in 3 and 15-months animals.
Voronina
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TA
Kutepova
O A
OA
D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004644:Emotions / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D011619:Psychotropic Drugs; D011725:Pyridines / Q000494:pharmacology*; D013997:Time Factors
D000975:Antioxidants; D011619:Psychotropic Drugs; D011725:Pyridines; C023500:3-hydroxypyridine
Vliianie antioksidanta iz klassa 3-oksipiridina na funktsional'nuiu aktivnost' tsentral'noĭ nervnoĭ sistemy mysheĭ raznykh vozrastnykh grupp.