[Function of the anticoagulant system when difensin is administered into the blood stream].
I. v. administration of defensin, nonenzyme cationic protein consisting of some peptides, to the rats with either activation or depression of anticoagulating system produced a moderate decrease of anticoagulating and fibrinolytic properties of the blood and did not intensify the depression of anticoagulating system. Neither did defensin affect the response of anticoagulating system when administered prior to injection of tromboplastin. These properties of defensin make it an efficient hemostatic drug.
Kudriashov
B A
BA
Ashmarin
I P
IP
Liapina
L A
LA
Kondashevskaia
M V
MV
Kokriakov
V N
VN
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D023082:Defensins; D004305:Dose-Response Relationship, Drug; D005342:Fibrinolysis / Q000187:drug effects; D006490:Hemostatics / Q000494:pharmacology*; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D011506:Proteins / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013925:Thromboplastin / Q000494:pharmacology; D013997:Time Factors
D023082:Defensins; D006490:Hemostatics; D010455:Peptides; D011506:Proteins; D013925:Thromboplastin; D002746:Chlorpromazine
Funktsional'noe sostoianie protivosvertyvaiushcheĭ sistemy pri vvedenii v krovotok difensina.