Structural alterations in the membrane of the slow muscle fiber of Rana temporaria after denervation.
Mixed fiber bundles as well as separated slow and fast fibers from normal and denervated muscles of Rana temporaria were freeze-fractured. The membranes of both fiber types are distinguished in this species by the presence of fairly regularly distributed particle aggregates or arrays of different shapes and sizes; the number per unit area of the membrane is six times higher in fast than in slow fibers. The intramembrane particle (IMP) density is higher in slow than in fast fibers. After denervation, the fast fiber membrane structure does not change whereas the slow fiber membrane acquires the characteristics of the fast fiber, i.e., an increase in the density of particle arrays and a decrease in IMP density. These changes in the slow fiber membrane are compared to the altered physiological properties of this fiber type after denervation.
Verma
V
V
I. Physiologisches Institut der Universität des Saarlandes, Homburg/Saar, Federal Republic of Germany.
Schmidt
H
H
Richter
H P
HP
D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure; D005614:Freeze Fracturing; D008854:Microscopy, Electron; D009121:Muscle Denervation; D009132:Muscles / Q000294:innervation / Q000648:ultrastructure*; D011896:Rana temporaria