Comparison of myoglobin and creatine kinase MB levels in the evaluation of myocardial injury after cardiac operations.
Myoglobin was studied in 40 patients before, during, and after cardiac operations and was compared to the MB isoenzyme of creatine kinase to identify its possible role as a marker of perioperative myocardial damage. Myoglobin reached peak values during cardiac arrest in all patients and was significantly higher immediately after administration of the anesthetics, during cardiac arrest, and until the sixth postoperative hour in eight patients with a perioperative myocardial infarction. By contrast, the MB isoenzyme of creatine kinase reached peak values at the fourth postoperative hour and was significantly higher in patients with perioperative myocardial infarction from the fourth to the tenth postoperative hours. We conclude that myoglobin is a valuable marker of perioperative myocardial damage and is an earlier and more specific marker of perioperative myocardial infarction than creatine kinase MB.
Séguin
J
J
Department of Thoracic and Cardiovascular Surgery, C.H.U. Hôpital Saint-Eloi, Montpellier, France.
Saussine
M
M
Ferrière
M
M
Sany
C
C
Coulon
P
P
Grolleau
R
R
Chaptal
P A
PA
D004796:Clinical Enzyme Tests; D001026:Coronary Artery Bypass; D003402:Creatine Kinase / Q000097:blood*; D006350:Heart Valve Prosthesis; D006801:Humans; D007527:Isoenzymes; D009203:Myocardial Infarction / Q000175:diagnosis*; D009211:Myoglobin / Q000097:blood*; D011183:Postoperative Complications / Q000175:diagnosis*; D013997:Time Factors
D007527:Isoenzymes; D009211:Myoglobin; D003402:Creatine Kinase