[Mechanism of action of voltaren on the smooth muscles of the blood vessels].
The effect of voltaren on the electrical and contractile activity of smooth muscle cells of the rabbit portal vein and the bovine cerebral arteries was studied by sucrose gap method. Voltaren was found to rarefy (10(-6)-10-10(-3)mol/l) or to suppress (10(-4)-10(-3)mol/l) spontaneous electrical and contractile activity and to relax the portal vein muscle strips. At concentrations of 5.10(-6)-5.10(-3) mol/l voltaren caused a dose-dependent relaxation of the cerebral arterial muscle strips. The relaxation of the smooth muscles of the blood vessels induced by voltaren is suggested to be due to inhibition of calcium ions influx into muscle cells through different types of calcium channels.
Gurkovskaia
A V
AV
Gokina
N I
NI
Stepaniuk
G I
GI
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002417:Cattle; D004008:Diclofenac / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D011433:Propranolol; D010646:Phentolamine
Mekhanizm deĭstviia vol'tarena na gladkie myshtsy krovenosnykh sosudov.