title: Uncoupling of hexose transport and phosphorylation in human gliomas demonstrated by PET.
abstract: Tumor uptake of [18F]2-fluoro-2-deoxy-glucose (FDG) was studied in 20 patients with histologically classified gliomas, using dynamic positron emission tomography (PET). Parametric images of local blood volume, glucose metabolic rate, transport and phosphorylation rate constants were generated by weighted non-linear least-squares fits on a pixel-by-pixel basis. Tumor metabolism, i.e. ratios of tumor peak metabolism to contralateral brain metabolism, corresponded with histological grade. Approximately half of the tumors showed considerable metabolic heterogeneity, and metabolically active areas were found in the periphery of seven tumors. Rate constants of FDG transport and phosphorylation were significantly correlated and were inversely coupled to plasma glucose levels in contralateral brain. In contrast, tumor transport and phosphorylation rate constants varied independently of each other and of plasma glucose concentration. In some tumors large alterations of FDG phosphorylation were observed in presence of nearly normal FDG transport.
authors.affiliation: Max-Planck-Institut für neurologische Forschung und Universitätsnervenklinik--Schwerpunkt Neurologie, Köln, Lindenthal, F.R.G.
authors.forename: K
authors.initials: K
authors.lastname: Herholz
authors.forename: P
authors.initials: P
authors.lastname: Ziffling
authors.forename: W
authors.initials: W
authors.lastname: Staffen
authors.forename: G
authors.initials: G
authors.lastname: Pawlik
authors.forename: R
authors.initials: R
authors.lastname: Wagner
authors.forename: K
authors.initials: K
authors.lastname: Wienhard
authors.forename: W D
authors.initials: WD
authors.lastname: Heiss
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001692:Biological Transport; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D002648:Child; D003837:Deoxy Sugars / Q000493:pharmacokinetics*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005910:Glioma / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D014055:Tomography, Emission-Computed
chemical_list: D003837:Deoxy Sugars; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose