title: Human satietin: rapid development of tolerance and its specificity to feeding behavior in rats.
abstract: Semipurified human satietin (SP hSAT) significantly (p less than 0.05) reduced food intake for each of five consecutive days when injected intraperitoneally (2 mg/kg/day). Tolerance developed rapidly during the second and third days of injection but food intake of those animals receiving the highest doses of Sp hSAT (1 and 2 mg/kg/day) remained significantly below (p less than 0.05) that of the saline-injected animals. Food intake of rats receiving doses of 0.5 and 0.25 mg/kg/day Sp hSAT was below that of the saline-treated group for the first two days of injection (p less than 0.05) but not thereafter. Water intake fell in all satietin-treated groups on the first day of injection, thereafter, it was similar to the saline-treated group. In a second study Sp hSAT (1, 0.5, 0.25 mg/kg/day) was continuously infused IP by Alzet pumps. All doses of Sp hSAT significantly reduced food intake below that of the saline-treated group for the entire 7 days of infusion (p less than 0.05); water was not affected except on the first day of infusion (p greater than 0.01). In a third study, injection of purified human satietin (p hSAT) (2 mg/kg, IP) in fasted rats (24 hr) had no effect on water consumption either during fast or 24 hr postfast (p greater than 0.05). In a fourth study p hSAT was continuously heated to 37 degrees C. Aliquots were taken each day and injected (IP) into 4 naive rats (total of 24 rats) for a total of 6 days of heating (120 hr).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Animal Physiology, University of California, Davis 95616.
authors.forename: V E
authors.initials: VE
authors.lastname: Mendel
authors.forename: R R
authors.initials: RR
authors.lastname: Benitez
authors.forename: T A
authors.initials: TA
authors.lastname: Tetzke
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004327:Drinking Behavior / Q000187:drug effects; D004361:Drug Tolerance; D005215:Fasting; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D006020:Glycopeptides / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D007262:Infusions, Intravenous; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D001067:Appetite Depressants; D006020:Glycopeptides; C035102:satietin