title: Activation of peripheral blood lymphocytes in patients with primary Sjögren's syndrome.
abstract: The peripheral blood from 15 patients with primary Sjögren's syndrome and from 15 matched controls was examined for the presence of activated T and B lymphocytes, by using monoclonal antibodies directed to interleukin-2 (IL-2) and transferrin receptors, and to HLA-DR determinants. The number of circulating positive-T cells was significantly greater in the patients than in the controls, irrespective of disease activity. There were more of the CD8 cells than of the CD4 cells that expressed IL-2 receptors. There was a small but significant increase in activated B cells in the patients, since this population is virtually absent from the normal blood.
authors.affiliation: Department of Immunology, University Hospital Medical School, Brest, France.
authors.forename: P
authors.initials: P
authors.lastname: Youinou
authors.forename: Y L
authors.initials: YL
authors.lastname: Pennec
authors.forename: M A
authors.initials: MA
authors.lastname: Blaschek
authors.forename: A
authors.initials: A
authors.lastname: Gentric
authors.forename: J
authors.initials: J
authors.lastname: Jouquan
authors.forename: A
authors.initials: A
authors.lastname: Lamour
authors.forename: P
authors.initials: P
authors.lastname: Angelidis
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis; D001402:B-Lymphocytes / Q000145:classification / Q000502:physiology; D006801:Humans; D008213:Lymphocyte Activation; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000097:blood* / Q000145:classification; D013601:T-Lymphocytes / Q000145:classification / Q000502:physiology
chemical_list: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation