title: Karyotypic rearrangements in 20 uterine leiomyomas.
abstract: Short-term cultures from 106 uterine leiomyomas have been cytogenetically investigated. In 29 cases the number of metaphases was insufficient for analysis. A normal female karyotype was found in 57 tumors and clonal chromosome rearrangements in 20. A reciprocal translocation, t(12;14) (q14----q15;q23----q24), was observed in 10 tumors and probably represents a primary change of tumorigenic importance. In four of the tumors containing this specific anomaly, secondary chromosome changes were also present. The 10 karyotypically abnormal leiomyomas without a t(12;14) had various structural and numerical aberrations involving chromosomes 1, 2, 3, 4, 6, 8, 9, 10, 11, 12, 13, and 19. Different structural changes of chromosome 1 were the second most frequent abnormalities, being found in five tumors. Ring chromosomes were observed in three cases, but never as the sole change.
authors.affiliation: Department of Clinical Genetics, Lund University Hospital, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Nilbert
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: U M
authors.initials: UM
authors.lastname: Flodérus
authors.forename: H
authors.initials: H
authors.lastname: Willén
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics*; D014594:Uterine Neoplasms / Q000235:genetics*