title: HLA-DR-expressing cells and T-lymphocytes in sural nerve biopsies.
abstract: Thirty-five sural nerve biopsies were stained immunohistochemically for HLA-DR antigen. HLA-DR was expressed on nonmyelinating Schwann cells, macrophages, vascular endothelium, and perineurium. By means of double immunofluorescence staining the identity of the HLA-DR presenting structures was confirmed. HLA-DR expression was found in all biopsies and thus was not restricted to any particular type of neuropathy. The HLA-DR expression appeared to correlate with severity and activity of the neuropathy. HLA-DR-expressing macrophages wrapping myelinated fibers were prominent in primary demyelinating neuropathies. T-cells were found in 6 out of 15 nerves examined. Their presence correlated with moderate to strong HLA-DR expression of nonmyelinating Schwann cells, and they occurred during active disease.
authors.affiliation: Department of Pathology, Karolinska Institute, Huddinge Hospital, Sweden.
authors.forename: H D
authors.initials: HD
authors.lastname: Schrøder
authors.forename: T
authors.initials: T
authors.lastname: Olsson
authors.forename: G
authors.initials: G
authors.lastname: Solders
authors.forename: K
authors.initials: K
authors.lastname: Kristensson
authors.forename: H
authors.initials: H
authors.lastname: Link
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008264:Macrophages / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000175:diagnosis*; D012583:Schwann Cells / Q000473:pathology; D013127:Spinal Nerves / Q000473:pathology*; D013497:Sural Nerve / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology*
chemical_list: D006684:HLA-DR Antigens