Regulation of dopamine release by the autoreceptor after repeated methamphetamine treatment in rats: an intracerebral dialysis study.
A group of rats received intraperitoneal injections of methamphetamine (MAP) once a day for 14 days. Seven days after the last injection, the striatal dopamine efflux and its inhibition by a low dose (100 micrograms/kg) of apomorphine were examined by in vivo intracerebral dialysis. The extent of inhibition was not altered after the MAP pretreatment, which does not suggest the presence of subsensitivity of dopamine auto-receptors.
Kazahaya
Y
Y
Department of Neuropsychiatry, Okayama University Medical School, Japan.
Hamamura
T
T
Otsuki
S
S
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects; D003956:Dialysis; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D009434:Neural Pathways / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D013378:Substantia Nigra / Q000187:drug effects
D011954:Receptors, Dopamine; D015102:3,4-Dihydroxyphenylacetic Acid; D008694:Methamphetamine; D001058:Apomorphine; D004298:Dopamine; D006719:Homovanillic Acid