Serum testosterone levels in experimental acute renal failure.
In dogs made uremic by bilateral ureteral ligation or by uranyl nitrate injection the serum testosterone levels were investigated. In both experimental models of acute renal failure a profound decrease of serum testosterone was found. The relationship between serum iPTH and testosterone levels was also investigated. The significant negative correlation between them was found in both groups of uremic animals, being more pronounced in the uranyl nitrate induced uremia (r = -0.762, p less than 0.001) than after bilateral ureteral ligation (r = -0.362, p less than 0.05). The simultaneous analysis of serum cortisol levels in both experimental groups as in sham operated controls indicated that stress factors in acute renal failure may also contribute to the testosterone decrease.
Ivić
M A
MA
Institute of Nephrology and Hemodialysis, Faculty of Medicine, Nis/Yugoslavia.
Strahinjić
S
S
Lajsić-Grubor
G
G
Stefanović
V
V
D058186:Acute Kidney Injury / Q000097:blood* / Q000503:physiopathology; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D013737:Testis / Q000378:metabolism / Q000503:physiopathology; D013739:Testosterone / Q000097:blood*; D014502:Uranyl Nitrate; D014511:Uremia / Q000097:blood / Q000503:physiopathology
D010281:Parathyroid Hormone; D014502:Uranyl Nitrate; D013739:Testosterone; D006854:Hydrocortisone