[The effects of localized therapy with postsurgical local recurrences of lung carcinoma and metastatic lung tumors--laser irradiation, IL-2+ LAK or ethanol injection].
Nd-YAG or Argon dye laser irradiations combined with radiotherapy were performed for lung cancer patients with central airway obstructions due to recurrences. Remarkable effects of immediate airway dilatation and reduction of symptoms were obtained after laser irradiations. IL-2 and LAK injections or ethanol injections into the peripheral recurrent or metastatic lung lesions. In one out of 5 patients after IL-2 and LAK injection, and in one out of 2 patients after ethanol injection, tumor size was reduced by 43% and 34%, respectively. IL-2 and/or LAK were injected into the pleural or pericardial spaces with malignant effusion, showing significant effects on a lung cancer patient with cancerous pericarditis who survived more than 9 months after this localized therapy. According to these results, these localized therapies may not always prove effective, but they should be applied to unresectable recurrent lung cancers or metastatic lung tumors in order to prolong survival with good quality of life.
Baba
M
M
Dept. of Surgery, School of Medicine, Chiba University.
Yamaguchi
Y
Y
Fujisawa
T
T
Kimura
H
H
D000230:Adenocarcinoma / Q000532:radiotherapy / Q000628:therapy; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000628:therapy; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007267:Injections; D007376:Interleukin-2 / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000637:transplantation; D053685:Laser Therapy; D008175:Lung Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy / Q000628:therapy*; D011013:Pneumonectomy; D011184:Postoperative Period
D007376:Interleukin-2; D000431:Ethanol