Propranolol for the control of disruptive behavior in senile dementia.
Six patients with senile dementia, exhibiting severe, disruptive behavior were effectively treated with propranolol in doses ranging from 80 mg per day to 560 mg per day. All six patients were given a trial of propranolol after conventional therapy had failed, and in all patients, the agitated behavior significantly improved. There were no adverse side effects requiring the discontinuation of the propranolol, and in all cases, the agitated behavior was controlled without inducing general sedation. Both the nursing home staff and the families were pleased with the therapeutic effects. Propranolol represents a possible alternative way of addressing the severe problem of agitated behavior in senile dementia patients.
Weiler
P G
PG
Center for Aging and Health, University of California, Davis 95616.
Mungas
D
D
Bernick
C
C
D000368:Aged; D000369:Aged, 80 and over; D000374:Aggression / Q000187:drug effects*; D000544:Alzheimer Disease / Q000188:drug therapy; D003704:Dementia / Q000188:drug therapy*; D015161:Dementia, Multi-Infarct / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D011433:Propranolol / Q000008:administration & dosage*; D011595:Psychomotor Agitation / Q000188:drug therapy*; D014754:Violence
D011433:Propranolol