Magnetic resonance imaging of the delivery of a paramagnetic contrast agent by an osmotic pump.
The successful application of Magnetic Resonance Imaging (MRI) in verifying the in vitro delivery action of an osmotically-driven pump (Alzet 2ML1) is described. MRI detection of drugs commonly used with such pumps is not yet possible because of the low signal intensity of present MR techniques. So we employed a paramagnetic contrast agent (gadolinium diethylene triamine penta acetic acid) of molecular weight comparable to commonly used drugs, and solutions of comparable concentration and viscosity. The study highlights the potential of this approach in the evaluation of in vivo drug delivery systems.
Carpenter
T A
TA
Laboratory for Medicinal Chemistry, University of Cambridge School of Medicine, Addenbrooke's Hospital, UK.
Hall
L D
LD
Hogan
P G
PG
D003287:Contrast Media / Q000008:administration & dosage*; D007260:Infusion Pumps; D008279:Magnetic Resonance Imaging; D008954:Models, Biological
D003287:Contrast Media