A preliminary behavioral investigation of PMMA, the 4-methoxy analog of methamphetamine.
The controlled-substance analog N-monomethyl-1-(4-methoxyphenyl)-2-aminopropane (PMMA) may be viewed as being either the 4-methoxy analog of methamphetamine or the N-methyl analog of 1-(4-methoxyphenyl)-2-aminopropane (PMA). Because of its abuse potential, PMMA was examined with regard to (a) its stimulus properties in rats trained to discriminate either 1.0 mg/kg of (+)amphetamine or (+/-)DOM from saline, (b) its toxicity (isolated and aggregated) in mice relative to (+/-)PMA, and (c) its locomotor stimulant activity in mice relative to (+/-)amphetamine, (+/-)methamphetamine, and (+/-)PMA. Racemic PMMA produced neither DOM-like nor, unlike PMA, amphetamine-like stimulus effects. There was no significant difference between the 24-hr isolated (LD50 = 63 mg/kg) and aggregated (LD50 = 53 mg/kg) toxicity, and PMMA did not produce significant locomotor stimulation at doses of up to 30 mg/kg. The present results suggest that while PMMA may produce central effects it does not appear to behave as a simple amphetamine-like agent.
Glennon
R A
RA
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond 23298.
Ismaiel
A E
AE
Martin
B
B
Poff
D
D
Sutton
M
M
D000661:Amphetamine / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D004193:Discrimination Learning / Q000187:drug effects*; D007928:Lethal Dose 50; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats
C060169:4-methoxymethamphetamine; D008694:Methamphetamine; D000661:Amphetamine