title: Immune status in patients with Menière's disease.
abstract: Sera of 164 patients with classical Meniere's disease were screened for autoantibodies, immune complexes and HLA status. Increased thyroid microsomal antibodies were significant in those patients in the 40- to 60-year age range. Raised IgM complexes and C1q component of complement were significant in all age groups. Low levels of IgA complexes were a consistent finding and were significantly lower in the HLA Cw7 group. Patients with migraine had no increased incidence of immune disturbances.
authors.affiliation: Department of Otolaryngology, London Hospital, Whitechapel, England.
authors.forename: K L
authors.initials: KL
authors.lastname: Evans
authors.forename: D L
authors.initials: DL
authors.lastname: Baldwin
authors.forename: D
authors.initials: D
authors.lastname: Bainbridge
authors.forename: A W
authors.initials: AW
authors.lastname: Morrison
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008575:Meniere Disease / Q000150:complications / Q000276:immunology*; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D006680:HLA Antigens; D007136:Immunoglobulins; D003165:Complement System Proteins