Effect of multidrug therapy on the levels of antibodies to Mycobacterium leprae glycolipid-1 in the leprosy spectrum.
Sera from one hundred and forty five untreated leprosy patients, ten proven cases of active pulmonary tuberculosis and twenty five healthy volunteers not exposed to M. leprae infection were assayed for PGL-1 antibodies. All available follow up samples after multidrug therapy were also assayed. A decline in the level of PGL-1 antibodies were seen in many of the post-treatment samples, giving an indirect assessment of the bacterial load and the prognosis of the disease.
Vaishnavi
C
C
Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ganguly
N K
NK
Sharma
V K
VK
Kaur
H
H
Kaur
S
S
D000907:Antibodies, Bacterial / Q000032:analysis*; D000942:Antigens, Bacterial; D002991:Clofazimine / Q000008:administration & dosage; D003622:Dapsone / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006017:Glycolipids / Q000276:immunology*; D006801:Humans; D015440:Leprosy, Lepromatous / Q000188:drug therapy* / Q000276:immunology; D011863:Radioimmunoassay; D012293:Rifampin / Q000008:administration & dosage
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D006017:Glycolipids; C045169:phenolic glycolipid I, Mycobacterium leprae; D003622:Dapsone; D002991:Clofazimine; D012293:Rifampin