Effect of MPTP-induced parkinsonism in monkeys on the urinary excretion of HVA and MHPG during debrisoquin administration.
During debrisoquin administration to three monkeys there were significant reductions in excretion rates of HVA, the major dopamine metabolite, and MHPG, the major norepinephrine metabolite. Excretion rates of HVA were highly correlated to those of MHPG. The regression line relating HVA and MHPG excretion suggests that a portion of HVA (about 25%) is derived from a source independent of norepinephrine metabolites. There was a striking reduction of this portion of HVA excretion after MPTP-induced destruction of dopaminergic nigrostriatal neurons. These results support the view that the rate of HVA formation in brain dopaminergic neurons can be estimated from the relationship of urinary excretion rates of HVA and MHPG before and during debrisoquin treatment.
Kopin
I J
IJ
National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20892.
Bankiewicz
K
K
Harvey-White
J
J
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D003404:Creatinine / Q000652:urine; D003647:Debrisoquin / Q000494:pharmacology*; D005260:Female; D006018:Glycols / Q000652:urine*; D006719:Homovanillic Acid / Q000652:urine*; D007546:Isoquinolines / Q000494:pharmacology*; D008253:Macaca mulatta; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000652:urine*; D011725:Pyridines; D012044:Regression Analysis
D006018:Glycols; D007546:Isoquinolines; D011725:Pyridines; D008734:Methoxyhydroxyphenylglycol; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D003404:Creatinine; D003647:Debrisoquin; D006719:Homovanillic Acid