Pertussis toxin inactivates the presynaptic serotonin autoreceptor in the hippocampus.
The serotonin (5-HT) agonists, D-lysergic acid diethylamide (LSD) and 5-methoxytryptamine (5-Me-O-T), dose dependently inhibited the K+-evoked outflow of [3H]5-HT from preloaded rat hippocampal slices in vitro, indicating activation of the 5-HT autoreceptor. However, this effect was abolished in slices pretreated with pertussis toxin. It is thus concluded that the 5-HT autoreceptor in the hippocampus is coupled to G proteins.
Passarelli
F
F
Department of Neuropharmacology, Max-Planck-Institut für Psychiatrie, München, F.R.G.
Costa
T
T
Almeida
O F
OF
D008735:5-Methoxytryptamine / Q000494:pharmacology; D000818:Animals; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D008719:Methiothepin / Q000494:pharmacology; D037342:Pertussis Toxin; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000378:metabolism; D010566:Virulence Factors, Bordetella / Q000494:pharmacology*
D011985:Receptors, Serotonin; D010566:Virulence Factors, Bordetella; D012701:Serotonin; D008735:5-Methoxytryptamine; D008719:Methiothepin; D008238:Lysergic Acid Diethylamide; D037342:Pertussis Toxin; D011188:Potassium