Determination of clozapine in human serum by capillary gas chromatography.
A gas chromatographic method using a fused-silica wide-bore capillary column and a nitrogen-specific detector for the determination of the antipsychotic agent clozapine in human serum is described. This method was found to be suitable for the determination of serum levels down to 1-2 ng/ml. The sensitivity, precision and accuracy of this method are adequate for studies on pharmacokinetics and bioavailability.
Richter
K
K
Institut für Klinische Pharmakologie der Medizinischen Akademie Carl Gustav Carus, Dresden, G.D.R.
D002849:Chromatography, Gas; D003024:Clozapine / Q000097:blood*; D003984:Dibenzazepines / Q000097:blood*; D006801:Humans
D003984:Dibenzazepines; D003024:Clozapine