Salivary flow rate, protein and electrolyte concentrations in chronic alcoholic patients.
Stimulated and unstimulated parotid salivas were examined in a series of non-cirrhotic patients under treatment for alcohol dependence and in age-sex matched, non-alcoholic, healthy, control subjects. Resting salivary flow was raised threefold in the alcohol group and the protein and electrolyte concentrations were also altered in this saliva. However, there were no intergroup differences in parotid flow or composition following gustatory stimulation by 6% citric acid. The results contrast with the wide parotid functional changes known to occur in stimulated parotid saliva in alcoholic cirrhosis and suggest, therefore, that the direct salivary effects of chronic alcohol abuse may be less important than the damaged liver function in contributing to the salivary disturbance reportedly occurring in alcoholic cirrhosis.
Scott
J
J
School of Dental Surgery, University of Liverpool, U.K.
Woods
K
K
Baxter
P
P
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000378:metabolism* / Q000503:physiopathology; D002712:Chlorides / Q000032:analysis; D004573:Electrolytes / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000378:metabolism; D011188:Potassium / Q000032:analysis; D012463:Saliva / Q000032:analysis / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000032:analysis*; D012636:Secretory Rate; D012964:Sodium / Q000032:analysis
D002712:Chlorides; D004573:Electrolytes; D012471:Salivary Proteins and Peptides; D012964:Sodium; D011188:Potassium