title: A case of carcinoid tumor of the middle ear producing peptide hormones.
abstract: We report 6th case of carcinoid tumor of the middle ear in a 16-year-old man. The clinical, histologic, immunohistochemical and ultrastructural features are discussed. The tumor in the attic and the tympanic cavity was successfully excised by radical mastoidectomy. Microscopically, the argyrophilic property and neurosecretory granules which are characteristic of carcinoid tumor were found in the cytoplasm of tumor cells. Furthermore, peptide hormones were confirmed immunohistochemically in this case. This tumor should be considered in the differential diagnosis when biologically lowgrade tumor with glandular and trabecular architectures are encountered in the middle ear.
authors.affiliation: Department of Otolaryngology, Sendai Red Cross Hospital, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Kambayashi
authors.forename: M
authors.initials: M
authors.lastname: Ishidoya
authors.forename: T
authors.initials: T
authors.lastname: Urae
authors.forename: S
authors.initials: S
authors.lastname: Saijo
authors.forename: R
authors.initials: R
authors.lastname: Yuasa
authors.forename: N
authors.initials: N
authors.lastname: Kimura
authors.forename: N
authors.initials: N
authors.lastname: Sasano
mesh_terms: D000293:Adolescent; D000328:Adult; D002276:Carcinoid Tumor / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D002864:Chromogranins / Q000032:analysis; D003937:Diagnosis, Differential; D004428:Ear Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D004432:Ear, Middle / Q000378:metabolism / Q000473:pathology*; D004744:Enkephalin, Methionine / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000032:analysis
chemical_list: D002864:Chromogranins; D012701:Serotonin; D004744:Enkephalin, Methionine