Nonrandom distribution of antibodies to the TRS protein of human immunodeficiency virus in infected people with different clinical status.
A transregulatory gene, trs, of human immunodeficiency virus I (HIV-1) was expressed in bacteria as a 26-kD fusion protein. Survey of over 100 individuals infected with HIV revealed a nonrandom distribution of seropositivity against trs: a few of the asymptomatic carriers and AIDS patients (less than 5%) had sera that reacted with the 26-kD protein. In contrast, 29% of the ARC patients' sera reacted positively. This result is different from those of serological reactivities of the other accessory gene products of HIV-1 (tat, sor, 3' orf, and R) which did not differentiate among stages of clinical progression. Since ARC is a prodrome for full-blown AIDS, these results suggest that trs may be useful as a prognostic marker for AIDS development.
Chanda
P K
PK
Wyeth Laboratories, Philadelphia, PA 19101.
Ghrayeb
J
J
Wong-Staal
F
F
D000386:AIDS-Related Complex / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D003001:Cloning, Molecular; D015694:Gene Products, rev; D005809:Genes, Regulator; D005814:Genes, Viral; D006678:HIV / Q000235:genetics / Q000276:immunology*; D015483:HIV Antibodies; D006801:Humans; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology; D014760:Viral Fusion Proteins / Q000235:genetics / Q000276:immunology*; D054321:rev Gene Products, Human Immunodeficiency Virus
D000914:Antibodies, Viral; D015694:Gene Products, rev; D015483:HIV Antibodies; D011994:Recombinant Proteins; D014760:Viral Fusion Proteins; D054321:rev Gene Products, Human Immunodeficiency Virus