title: [X-ray crystallographic studies of diclofenac-sodium--structural analysis of diclofenac-sodium tetrahydrate].
abstract: The crystal structure of the hydrate of the antiphlogistic drug diclofenac sodium was determined to explain the unusual dissolution behaviour in ethyl acetate. The compound crystallizes in the monoclinic space group P2(1)/m with a = 9.464(2), b = 39.405(7), c = 9.972(3) A und beta = 90.74(2) degrees. The unit cell contains two symmetry independent formula units (C14H10Cl2NO2)-Na+.3,94 H2O. There are molecule layers and sodium-water layers which show order-disorder phenomena.
authors.affiliation: Zentralinstitut für Molekularbiologie, Akademie der Wissenschaften der DDR, Berlin-Buch.
authors.forename: G
authors.initials: G
authors.lastname: Reck
authors.forename: G
authors.initials: G
authors.lastname: Faust
authors.forename: G
authors.initials: G
authors.lastname: Dietz
mesh_terms: D003460:Crystallization; D004008:Diclofenac / Q000032:analysis*; D008968:Molecular Conformation; D014961:X-Ray Diffraction
chemical_list: D004008:Diclofenac
vernacular_title: Röntgenkristallographische Untersuchungen an Diclofenac-Natrium--Strukturanalyse des Diclofenac-Natrium Tetrahydrat.