Effect of trenbolone and testosterone on the plasma elimination rates of sulfamethazine, trimethoprim, and antipyrine in female dwarf goats.
Plasma elimination rates of sulfamethazine (100 mg/kg of body weight, IV), trimethoprim (20 mg/kg, IV), and antipyrine (35 mg/kg, IV) were studied in adult female dwarf goats (n = 5) before and after implantation with trenbolone acetate (5 mg/kg). Pretreatment with trenbolone caused a significant decrease in the elimination rate of the drugs tested: for sulfamethazine, 5 times; for antipyrine, 3 times; and for trimethoprim, 2 times. After treatment with testosterone (1 mg/kg, SC, twice weekly for 2.5 weeks), female goats (n = 5) had a similar decrease in the elimination rate of sulfamethazine. Other induced effects included a change in social behavior, a lower voice, and the development of a typical billy goat-like odor. Plasma creatinine concentrations after androgen administration were significantly higher than those before androgen administration; changes were not observed in plasma urea values. Because of the differences observed, we believe that more attention should be paid to the effects of androgenic agents on drug kinetic properties, with particular reference to studies on clinical efficacy, side effects, and drug residues in food products.
van Miert
A S
AS
Department of Veterinary Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, State University of Utrecht, The Netherlands.
Peters
R H
RH
Basudde
C D
CD
Nijmeijer
S N
SN
van Duin
C T
CT
van Gogh
H
H
Korstanje
C
C
D000818:Animals; D000983:Antipyrine / Q000097:blood*; D004350:Drug Residues / Q000032:analysis; D004963:Estrenes / Q000494:pharmacology*; D005260:Female; D006041:Goats / Q000097:blood*; D007275:Injections, Intravenous; D013418:Sulfamethazine / Q000097:blood*; D013739:Testosterone / Q000008:administration & dosage / Q000494:pharmacology*; D014204:Trenbolone Acetate / Q000008:administration & dosage / Q000494:pharmacology*; D014295:Trimethoprim / Q000097:blood*
D004963:Estrenes; D013739:Testosterone; D013418:Sulfamethazine; D014295:Trimethoprim; D014204:Trenbolone Acetate; D000983:Antipyrine