[2 phenotypic variants of B-cell lymphocytic leukemia].
A phenotype of lymphoid cells of peripheral blood in 38 patients with B-cel chronic lymphocytic leukaemia (B-CLL) was determined by means of a set of monoclonal antibodies. In the majority of the cases (32 persons--group I) the cells had an incomplete phenotype (CD 20+, CD 21-, CD 22-, CD 24+, CD 37+). In 6 patients (group II) cells had all the surface markers peculiar to B-CLL cells (phenotype--CD 20+, CD 21+, CD 22+, CD 24+, CD 37+). In 2 out of 6 cases lymphoid cells contained E-receptor (CD 2+). Cells of the patients from group I and II differed also in the level of TUI-receptor. An assumption is advanced about the existence of two phenotypic variants of B-CLL and about a possible association of CD 21 and CD 22 receptors.
Merson
A G
AG
Brosh'e
Zh
Zh
Gipsh
N M
NM
Karminskaia
N M
NM
Udris
O Iu
OIu
D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000145:classification* / Q000235:genetics / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011947:Receptors, Antigen, B-Cell / Q000032:analysis
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D011947:Receptors, Antigen, B-Cell
Dva fenotipicheskikh varianta B-kletochnogo khronicheskogo limfoleĭkoza.