title: [The Ha(La) antibody as a serologic marker of systemic lupus erythematosus].
abstract: Ha(La)-antibodies are detected by counterimmunoelectrophoresis (CIE) in sera of systemic lupus erythematosus (SLE) patients, but not in sera of patients with progressive systemic scleroderma (PSS) (n = 38), rheumatoid arthritis (n = 91), ankylosing spondylitis (n = 97), and other rheumatic diseases (n = 452). This antibody specificity was found in 27 out of 103 SLE patients (26%). However, 50% of SLE patients with Sjögren's syndrome (n = 12) showed the Ha(La)-antibody, suggesting a strong association in this clinical subgroup. Thus the Ha(La)-antibody can serve as a serological marker and helpful diagnostic tool for SLE. Additionally, the Ha(La)-antibody reacts with specific puffs in polytene chromosome preparations of Drosophila melanogaster. Therefore, this heterologous antigen system is suitable for the identification of Ha(La) sera.
authors.affiliation: Medizinische Klinik und Poliklinik C, Universität Düsseldorf.
authors.forename: H J
authors.initials: HJ
authors.lastname: Lakomek
authors.forename: S
authors.initials: S
authors.lastname: Wagener
authors.forename: M
authors.initials: M
authors.lastname: Schwochau
authors.forename: H L
authors.initials: HL
authors.lastname: Krüskemper
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis*; D000918:Antibody Specificity; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000276:immunology; D012859:Sjogren's Syndrome / Q000175:diagnosis
chemical_list: D000974:Antibodies, Antinuclear; C035357:SS-B antibodies
vernacular_title: Der Ha(La)-Antikörper als serologische Kenngrösse des systemischen Lupus erythematodes (SLE).