The acute effect of doxorubicin and its analogue--4'-epidoxorubicin on circulatory system in rabbits.
The acute influence of doxorubicin (DXR) and its analogue - 4'-epidoxorubicin (4'-epiDXR) on cardiovascular system in rabbits was compared. A single intravenous dose of DXR (1 and 3 mg/kg) did not affect the cardiac index, stroke index and heart rate, but reduced the mean arterial blood pressure and total peripheral resistance. In contrast, 4-epiDXR, in the same doses, did not affect any of the hemodynamic parameters.
Drzewoski
J
J
Department of Pharmacology, Medical Academy, Lódź, Poland.
Polakowski
P
P
Kaszubski
P
P
Orszulak-Michalak
D
D
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology*; D015251:Epirubicin / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D015251:Epirubicin; D004317:Doxorubicin