Bronchodilator effect and serum theophylline level after combined treatment with fenoterol and theophylline in reversible chronic airflow obstruction.
Sustained-release theophylline 10.1 mg/kg b.d. was given with placebo of fenoterol 2.5 mg t.d.s. to 12 patients with chronic airway obstruction. Fenoterol did not significantly affect the steady state serum theophylline trough level (11.84 micrograms/ml for fenoterol vs 11.10 micrograms/ml for placebo). Addition of fenoterol produced no further increase in spirometric function nor in clinical status.
Lucena
M I
MI
Department of Clinical Pharmacology, School of Medicine, Malaga, Spain.
Almagro
J
J
Rius
F
F
Sanchez de la Cuesta
F
F
D000328:Adult; D000368:Aged; D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005280:Fenoterol / Q000494:pharmacology* / Q000627:therapeutic use; D006439:Hemodynamics; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy / Q000378:metabolism*; D008875:Middle Aged; D011897:Random Allocation; D012129:Respiratory Function Tests; D013806:Theophylline / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use
D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D005280:Fenoterol; D013806:Theophylline