title: Lack of effect of cholestyramine on phenytoin bioavailability.
abstract: The effect of cholestyramine (4 g qid for 5 days) on the kinetics of phenytoin (400 mg orally) was investigated in normal subjects. Apart from a trend toward faster phenytoin absorption, the serum level profile of the drug during concurrent cholestyramine coadministration was similar to that observed in a control session. Areas under the serum phenytoin concentration curves were virtually identical in the two occasions. It is concluded that cholestyramine does not significantly affect the bioavailability of a single dose of phenytoin.
authors.affiliation: Department of Internal Medicine and Therapeutics, University of Pavia, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Barzaghi
authors.forename: M
authors.initials: M
authors.lastname: Monteleone
authors.forename: C
authors.initials: C
authors.lastname: Amione
authors.forename: S
authors.initials: S
authors.lastname: Lecchini
authors.forename: E
authors.initials: E
authors.lastname: Perucca
authors.forename: G M
authors.initials: GM
authors.lastname: Frigo
mesh_terms: D000328:Adult; D001682:Biological Availability; D002792:Cholestyramine Resin / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000493:pharmacokinetics*
chemical_list: D002792:Cholestyramine Resin; D010672:Phenytoin