The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens.
T cells with V beta 3+ alpha beta receptors are deleted by self-tolerance in mice with particular major histocompatibility complex/self-antigen combinations. This also occurs for other V beta elements. Polymorphism in the major histocompatibility complex and/or the self-antigens that cause massive deletion of T cells using particular V beta elements may be maintained by the need to balance the advantage of a diverse T-cell repertoire against the potential involvement of those elements in autoimmune disease.
Pullen
A M
AM
Howard Hughes Medical Institute, Denver, Colorado.
Marrack
P
P
Kappler
J W
JW
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis; D001324:Autoantigens / Q000235:genetics / Q000276:immunology*; D002678:Chimera; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology; D006825:Hybridomas / Q000276:immunology; D007108:Immune Tolerance; D008285:Major Histocompatibility Complex; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D011110:Polymorphism, Genetic; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D001324:Autoantigens; D006183:H-2 Antigens; D011948:Receptors, Antigen, T-Cell