Lack of effect of atenolol on the pharmacokinetics of theophylline.
The effects of 3 days of pretreatment with cardioselective doses of atenolol on theophylline pharmacokinetics were determined. Nine healthy nonsmoking male volunteers received 6 mg kg-1 i.v. aminophylline under baseline conditions and after both 50 mg day-1 and 100 mg day-1 atenolol. Theophylline clearance, volume of distribution and half-life were not influenced by atenolol pretreatment. These data indicate that cardioselective doses of atenolol do not alter the pharmacokinetics of theophylline.
Cerasa
L A
LA
Department of Pharmacy, State University of New York, Buffalo 14260.
Bertino
J S
JS
Ludwig
E A
EA
Savliwala
M
M
Middleton
E
E
Slaughter
R L
RL
D000328:Adult; D001262:Atenolol / Q000494:pharmacology*; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D008297:Male; D013806:Theophylline / Q000493:pharmacokinetics*
D001262:Atenolol; D013806:Theophylline