title: Alprazolam dependence in seven patients.
abstract: The authors report on seven patients who met the DSM-III-R criteria for psychoactive substance (alprazolam) dependence. All had withdrawal symptoms, six demonstrated tolerance, and at least four had substantial social or occupational impairment secondary to drug use. All seven patients had begun taking alprazolam as treatment for anxiety or depression. Six patients abused other drugs or alcohol, either in the past or concurrently. Doses of alprazolam ranged from 2 to 12 mg/day, and duration of use was 6 months to 3 years. The potential for dependence should be considered when prescribing alprazolam.
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905.
authors.forename: S M
authors.initials: SM
authors.lastname: Juergens
authors.forename: R M
authors.initials: RM
authors.lastname: Morse
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications; D000525:Alprazolam / Q000009:adverse effects; D001008:Anxiety Disorders / Q000188:drug therapy; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000150:complications; D008875:Middle Aged; D012640:Seizures / Q000139:chemically induced; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000209:etiology; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000209:etiology
chemical_list: D000525:Alprazolam