Treatment of gold-induced aplastic anaemia with immunosuppressive therapy.
Between June 1978 and August 1985 12 patients with gold-induced aplastic anaemia were treated with immunosuppressive therapy. Median age was 38.5 years for the 11 females and one male. Treatment regimens varied, but all patients received 150-160 mg/kg horse anti-human thymocyte globulin (ATG) over 4-10 d. Five patients had complete recovery of peripheral counts and one patient had a partial response. Of the six nonresponders one had a spontaneous recovery a year later and five died 6-67 d after beginning treatment. Seven patients are alive 4.3-8.9 years later. Six patients remain haematologically stable and one patient has developed a myelodysplastic syndrome. This experience confirms earlier reports of patients recovering marrow function after receiving immunosuppressive therapy for gold-related aplasia.
Doney
K
K
Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle 98104.
Storb
R
R
Buckner
C D
CD
Thomas
E D
ED
D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000139:chemically induced / Q000628:therapy*; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D005260:Female; D006046:Gold / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
D000961:Antilymphocyte Serum; D006046:Gold