[Characteristics of production and sorption of interleukin 2 by lymphoid cells during growth of transplanted sarcoma].
The ability of lymph node and spleen cells to secrete and sorb interleukin-2 (IL-2) during the growth of sarcomas induced by 20-methylcholanthrene is studied. Lymph node cells show an increased level of IL-2 production at early stages of the tumour growth whereas spleen cells produced IL-2 in minimal amounts. A decrease in the IL-2 production by lymph node cells with the tumour growth and a relative increase of IL-2 production in the spleen cell pool are observed. At all stages of the tumour growth the ability of lymphoid cells to sorb IL-2 decreased strongly in comparison with the analogous cells of normal animals activated by mitogen. Lymph node cells of animals with tumour sorb IL-2 more effectively than splenocytes.
Kushko
L Ia
LIa
Semenova-Kobzar'
R A
RA
Iudin
V M
VM
Koval'chuk
E V
EV
Berezhnaia
N M
NM
D000818:Animals; D007376:Interleukin-2 / Q000096:biosynthesis*; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D013154:Spleen / Q000473:pathology
D007376:Interleukin-2
Osobennosti produktsii i sorbtsii interleĭkina-2 limfoidnymi kletkami v dinamike rosta perevivnykh sarkom.