Effects of naloxone and picrotoxin on diazepam- or pentobarbital-induced hyperphagia in nondeprived rats.
Diazepam and pentobarbital administered intravenously increased food intake in a dose-dependent manner in nondeprived rats. Low doses of naloxone inhibited diazepam-induced feeding, but did not inhibit pentobarbital-induced feeding. On the other hand, picrotoxin inhibited feeding induced by both drugs. These findings suggest that diazepam-induced hyperphagia is related to endogenous opioid mechanisms, but pentobarbital-induced hyperphagia is not. Hyperphagia induced by both drugs may be related to GABAergic neurons.
Naruse
T
T
Central Research Laboratories, Banyu Pharmaceutical Co. Ltd., Tokyo, Japan.
Asami
T
T
Koizumi
Y
Y
D000818:Animals; D003975:Diazepam / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D006963:Hyperphagia / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D010424:Pentobarbital / Q000009:adverse effects*; D010852:Picrotoxin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D003975:Diazepam; D009270:Naloxone; D010424:Pentobarbital; D010852:Picrotoxin