title: Comparison of cardiopulmonary effects of isoflurane and halothane after atropine-guaifenesin-thiamylal anesthesia for rumenotomy in steers.
abstract: Cardiopulmonary effects were assessed in 12 yearling steers anesthetized with guaifenesin and thiamylal sodium, intubated, and allowed to breathe isoflurane or halothane in oxygen spontaneously. Light surgical anesthesia, determined using eye position as a clinical indication of anesthetic depth, was maintained during surgical placement of a rumen cannula. Heart rate and respiratory rate were measured while the steers were standing quietly (baseline). Atropine (0.06 mg/kg of body weight, IM) was given after baseline measurements were taken. Heart rate, respiratory rate, arterial blood pressures, pHa, PaCO2, PaO2, arterial [HCO3-], esophageal temperature, and end-tidal anesthetic concentration were measured every 15 minutes for 90 minutes after induction of anesthesia. Mean heart rate increased significantly (P less than 0.05) above baseline in the isoflurane group at 15 and 30 minutes. Mean respiratory rate increased significantly (P less than 0.05) above baseline in the halothane group at 45 minutes. At 45 minutes, mean respiratory rate was lower (P less than 0.05) in the isoflurane group, compared with that in the halothane group. Mean values for arterial blood pressures and arterial gases were similar for both agents at comparable times. Mean end-tidal isoflurane concentrations were less than mean end-tidal halothane concentrations at each comparable time during maintenance of similar anesthetic depth. Maintenance of anesthesia with isoflurane resulted in higher heart rates and lower respiratory rates, compared with maintenance of anesthesia with halothane in these steers.
authors.affiliation: Department of Large Animal Medicine and Surgery, Texas Veterinary Medical Center, Texas A&M University, College Station 77843.
authors.forename: S A
authors.initials: SA
authors.lastname: Greene
authors.forename: C L
authors.initials: CL
authors.lastname: Tyner
authors.forename: D L
authors.initials: DL
authors.lastname: Morris
authors.forename: S M
authors.initials: SM
authors.lastname: Hartsfield
mesh_terms: D000768:Anesthesia, General / Q000662:veterinary; D000769:Anesthesia, Inhalation / Q000662:veterinary; D000818:Animals; D001285:Atropine; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002404:Catheterization / Q000662:veterinary; D002417:Cattle / Q000502:physiology*; D006140:Guaifenesin; D006221:Halothane / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D012119:Respiration / Q000187:drug effects*; D012417:Rumen / Q000601:surgery; D013840:Thiamylal
chemical_list: D013840:Thiamylal; D006140:Guaifenesin; D001285:Atropine; D007530:Isoflurane; D006221:Halothane