[Chemotherapy of renal cell carcinoma: experimental study and clinical effect].
In vitro sensitivity tests of 6 antineoplastic agents (mitomycin C, bleomycin, adriamycin, Vinblastine , cis-dichlorodiamine platinum, ACNU) were carried out on cultured cell line (OUR-10) established from human renal cell carcinoma and the results were compared with clinical results of 16 cases of renal cell carcinoma treated in our clinic. The effect of these drugs was estimated from the cell growth curve and DNA histogram determined by flow cytometry. All these drugs showed a concentration dependent effect. However, the usefulness of these drugs was not recognized in 10 clinical cases of advanced tumors.
Kanda
H
H
Department of Urology, Kinki University School of Medicine.
Matsuura
T
T
Akiyama
T
T
Kurita
T
T
D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004273:DNA, Neoplasm / Q000378:metabolism; D005434:Flow Cytometry; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm