title: Expression of Pre-S-encoded proteins in sera of individuals chronically infected with hepatitis D virus.
abstract: The sera of 16 individuals chronically infected with the hepatitis D virus were analyzed for hepatitis B virus (HBV) markers. The majority of these patients had a non-replicative form of viral type B hepatitis as indicated by negative tests for HBeAg and HBV-DNA. Pre-S-encoded proteins were detected in 13/16 sera. Sera that were negative for polymerized serum albumin did also not contain pre-S1-encoded proteins. The presence of pre-S-encoded proteins is probably predominantly associated with 22-nm HBsAg forms present in large amounts in sera of individuals with chronic type D hepatitis.
authors.affiliation: I. Medizinische Klinik der Johannes-Gutenberg-Universität Mainz, BRD.
authors.forename: G
authors.initials: G
authors.lastname: Hess
authors.forename: B
authors.initials: B
authors.lastname: Möller
authors.forename: G
authors.initials: G
authors.lastname: Gerken
authors.forename: C
authors.initials: C
authors.lastname: Weber
authors.forename: M
authors.initials: M
authors.lastname: Manns
authors.forename: K H
authors.initials: KH
authors.lastname: Meyer zum Büschenfelde
mesh_terms: D002908:Chronic Disease; D004279:DNA, Viral / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis; D003699:Hepatitis D / Q000097:blood*; D006801:Humans; D011498:Protein Precursors / Q000032:analysis*; D014759:Viral Envelope Proteins / Q000032:analysis*
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D011498:Protein Precursors; D014759:Viral Envelope Proteins; C050806:presurface protein 1, hepatitis B surface antigen; C050807:presurface protein 2, hepatitis B surface antigen