Chromosomal localisation of a developmental gene in man: direct DNA analysis demonstrates that Greig cephalopolysyndactyly maps to 7p13.
Greig cephalopolysyndactyly syndrome (GCPS) is a rare autosomal dominant form of complex polydactyly. GCPS has been tentatively assigned to chromosome 7 on the basis of association of the condition with balanced translocations involving the short arm of chromosome 7 (7p13) in two families. Seven GCPS pedigrees with no chromosome abnormality were studied, and linkage was demonstrated between GCPS and the DNA sequence coding for the receptor for epidermal growth factor (localised to 7p12-13) (Z = 3.17; O = theta).
Brueton
L
L
Division of Inherited Metabolic Disease, Northwick Park Hospital, Harrow, Middlesex, United Kingdom.
Huson
S M
SM
Winter
R M
RM
Williamson
R
R
D002897:Chromosomes, Human, Pair 7; D015342:DNA Probes; D005530:Foot Deformities / Q000235:genetics*; D006226:Hand Deformities / Q000235:genetics*; D006801:Humans; D010375:Pedigree
D015342:DNA Probes