Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes.
The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H-Y) antigen in the context of class I H-2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively high surface-density of CD8 molecules, including nonmature CD4+ CD8+ thymocytes, and is not caused by anti-idiotype cells.
Kisielow
P
P
Basel Institute for Immunology, Switzerland.
Blüthmann
H
H
Staerz
U D
UD
Steinmetz
M
M
von Boehmer
H
H
D000818:Animals; D000911:Antibodies, Monoclonal; D005260:Female; D006182:H-Y Antigen / Q000235:genetics / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010641:Phenotype; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology*; D012727:Sex Characteristics; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D006182:H-Y Antigen; D011948:Receptors, Antigen, T-Cell