[Preclinical toxicologic study of glyciram].
A preclinical study of safety of a plant preparation glyciram was carried out. At a single administration to laboratory animals the preparation is virtually a nontoxic compound. Intragastric administration of glyciram for 6 months in doses of 100 and 250 mg/kg may produce in animals functional changes of the liver and kidneys, which one should take into consideration when prescribing the preparation to patients suffering from diseases of these organs. The use of glyciram in doses of from 10 to 250 mg/kg causes no remote consequences--allergic, immunodepressive reactions, embryo-toxic, teratogenic and mutagenic effects.
Tataurova
T A
TA
Krepkova
L V
LV
Bortnikova
V V
VV
Kuznetsova
Iu B
IuB
Eniutina
E Iu
EIu
D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects; D001774:Blood Chemical Analysis; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D006034:Glycyrrhetinic Acid / Q000633:toxicity*; D007166:Immunosuppressive Agents; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009152:Mutagenicity Tests; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
D007166:Immunosuppressive Agents; D006034:Glycyrrhetinic Acid
Toksikologicheskoe doklinicheskoe izuchenie glitsirama.