title: Serum and erythrocyte magnesium levels in junior high school students: relation to blood pressure and a family history of hypertension.
abstract: Serum and erythrocyte magnesium concentrations (S-Mg, E-Mg) were measured in 380 Japanese junior high school students, and the relationship to blood pressure and a family history of hypertension were studied. Systolic blood pressure was higher in the subjects with a positive family history of hypertension [FH(+)] than in those with a negative family history [FH(-)], whereas E-Mg was lower in the FH(+) group than in the FH(-) group with a significant different in boys. Furthermore, in the FH(+) group, systolic blood pressure was significantly higher in the subjects with lower S-Mg and E-Mg than in those with higher S-Mg and E-Mg. In the FH(-) group, however, no difference was observed in blood pressure levels between the two subgroups. These findings suggest that magnesium deficiency is partially responsible for a rise of blood pressure in the FH(+) children, and that a genetic predisposition of hypertension may be closely related to magnesium metabolism.
authors.affiliation: Department of Hygiene, Hyogo College of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shibutani
authors.forename: K
authors.initials: K
authors.lastname: Sakamoto
authors.forename: S
authors.initials: S
authors.lastname: Katsuno
authors.forename: S
authors.initials: S
authors.lastname: Yoshimoto
authors.forename: T
authors.initials: T
authors.lastname: Matsuura
mesh_terms: D000293:Adolescent; D001794:Blood Pressure; D004912:Erythrocytes / Q000032:analysis*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008274:Magnesium / Q000097:blood*; D008297:Male
chemical_list: D008274:Magnesium