[Assessment of the calcium homeostatic state using the double calcium tolerance test].
An acute tolerance test per os using calcium (Ca) lactate at a dose of 0.25 mmol of Ca per kg of body mass (calcium tolerance test--CTT) was performed twice in healthy persons (HP) and in patients with chronic heart failure (CHF) of various degrees: before and after 3-day administration of the same dose of Ca lactate. The "double" CTT made it possible to detect in HP and CHF a "phenomenon of adaptation" to Ca excess in the body based probably on changes in the activity of calcium-regulating hormones. It was manifested in less marked and prolonged tolerance hypercalcemia and a more rapid and effective calciuretic reaction, and probably in decreased intestinal absorption of Ca. It pointed to reversibility of Ca metabolic derangements even in severe CHF and a possibility of their non-medicamentous correction.
Merzon
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KA
D002118:Calcium / Q000378:metabolism*; D002136:Calcium, Dietary / Q000008:administration & dosage; D002908:Chronic Disease; D005246:Feedback; D006333:Heart Failure / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D006934:Hypercalcemia / Q000378:metabolism; D007773:Lactates; D019344:Lactic Acid; D013997:Time Factors
D002136:Calcium, Dietary; D007773:Lactates; D019344:Lactic Acid; D002118:Calcium
Otsenka sostoianiia gomeostaza kal'tsiia s pomoshch'iu sdvoennogo kal'tsiĭ-tolerantnogo testa.