Central sodium loading modifies norepinephrine content in the ventrolateral medulla and blood pressure in rats.
We evaluated the effects of intracerebroventricular (ICV) infusion of hypertonic NaCl on blood pressure (BP) control as well as on NE content in the ventrolateral medulla (VLM). Nine groups of Wistar rats received 10 day's ICV infusion of NaCl solutions containing either norepinephrine (NE, 1.3 micrograms/min) or a synthetic NE precursor, 1-threo-3,4-dihydroxyphenylserine (1-DOPS, 17 micrograms/min) for 3 concentrations (0.15M, 0.8M or 1.5M) of NaCl. On day 9, only the group on ICV infusion of 1.5M NaCl alone had a significant rise in BP (133 +/- 3 mmHg, P less than 0.05 vs control) while other groups remained normotensive. The ICV infusion of 1.5M NaCl reduced NE content, determined by a microdialysis method, in the VLM while the concomitant ICV infusion of NE or 1-DOPS restored it suggesting that the decrease in NE content in the VLM may be a contributing factor in the BP elevation by the central salt loading.
Mikami
H
H
Department of Medicine and Geriatrics, Osaka University Medical School, Japan.
Ogihara
T
T
Katahira
K
K
Tsunetoshi
T
T
Kohara
K
K
Otsuka
A
A
Kumahara
Y
Y
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003956:Dialysis; D006982:Hypertonic Solutions; D007276:Injections, Intraventricular; D008297:Male; D008526:Medulla Oblongata / Q000032:analysis* / Q000187:drug effects; D009638:Norepinephrine / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000008:administration & dosage / Q000494:pharmacology*
D006982:Hypertonic Solutions; D012964:Sodium; D009638:Norepinephrine