Interleukin 2 modifies the bioelectric activity of some neurosecretory nuclei in the rat hypothalamus.
Introduction of 15-30 U of interleukin-2 (IL-2) into the 3rd ventricle of Wistar rats was followed by a marked and significant decrease in neuron discharge frequency in the ventromedial nucleus of hypothalamus and a marked increase in the supraoptic and paraventricular nuclei. The monoclonal antibody ART62 partly blocked these effects. The conventional anti-IL-2 receptor monoclonal antibody ART18 had only a non-significant influence on the effects of IL-2. Since the supraoptic and paraventricular nuclei secrete the antidiuretic hormone, their excitation may offer a partial explanation of the considerable water retention observed during IL-2 therapy against neoplasia.
Bindoni
M
M
Institute of Human Physiology, University of Catania, Italy.
Perciavalle
V
V
Berretta
S
S
Belluardo
N
N
Diamantstein
T
T
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D007276:Injections, Intraventricular; D007376:Interleukin-2 / Q000276:immunology / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000911:Antibodies, Monoclonal; D007376:Interleukin-2