title: Effect of human recombinant interleukin 5 and G-CSF on eosinophil colony formation.
abstract: Human recombinant (r) IL-5 was shown to have the activity to stimulate eosinophil (Eo) colony formation from human non-T, non-adherent bone marrow cells. The majority of these colonies were found to contain a small number of basophils, macrophages or neutrophils. Human rG-CSF, which alone did not stimulate Eo colony formation, showed an enhancing effect on Eo colony formation when added with IL-5. IL-5 seems to stimulate the proliferation and differentiation of CFU-Eo, while G-CSF acts on the early stage of eosinophilopoiesis.
authors.affiliation: Third Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Enokihara
authors.forename: S
authors.initials: S
authors.lastname: Nagashima
authors.forename: T
authors.initials: T
authors.lastname: Noma
authors.forename: H
authors.initials: H
authors.lastname: Kajitani
authors.forename: H
authors.initials: H
authors.lastname: Hamaguchi
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Furusawa
authors.forename: H
authors.initials: H
authors.lastname: Shishido
authors.forename: T
authors.initials: T
authors.lastname: Honjo
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003114:Colony-Forming Units Assay; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D004804:Eosinophils / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D015848:Interleukin-5; D007378:Interleukins / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D003115:Colony-Stimulating Factors; D015848:Interleukin-5; D007378:Interleukins; D011994:Recombinant Proteins