Filterability of human erythrocytes--drug induced prevention of aging in vitro.
Using a computer assisted filtration system, 6 drugs (bencyclane, moxaverine, naftidrofuryl, pentoxyfylline, vincamine, vinpocetine) were tested (versus placebo) to improve filterability of in vitro aged red blood cells (RBC). Up to a concentration of 1 x 10(-7) mol/l all drugs significantly inhibit in vitro aging, indicating an improved of action is still present in RBC incubated with 10 x 10(-8) mol/l naftidrofuryl and pentoxifylline but, comparison in between the compounds reveals no significant difference of action. The data presented confirm the results on the beneficial action of these drugs presented by others. However, direct comparison shows only minor differences in drug potency.
Bayer
R
R
Department of Clinical Physiology, University of Düsseldorf, Fed. Rep. of Germany.
Plewa
S
S
Borcescu
E
E
Claus
W
W
D000328:Adult; D004905:Erythrocyte Aging / Q000187:drug effects*; D004907:Erythrocyte Deformability / Q000187:drug effects*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male