Effect of human growth hormone and somatomedin on the recovery of sheep red blood cell receptor in peripheral T-lymphocytes.
The effect of growth hormone (GH) and somatomedin (SM) on the recovery of sheep red blood cell (SRBC) receptor in trypsinized human T-lymphocytes was studied either with the use of sera from patients with acromegaly or pituitary dwarfism or after the addition of exogenous GH, SM or thymosin to human sera. It was found that GH does not show any effect on the recovery of SRBC receptor, but it may act through the increase of SM level. It was concluded that the regulation of cellular immunity may be influenced by GH through its stimulatory action on the synthesis and release of somatomedins.
Rovensky
J
J
State Institute for Drug Control, Bratislava, Czechoslovakia.
Marek
J
J
Schreiberová
O
O
Hníková
O
O
Vigas
M
M
Strindberg
B
B
Lukác
P
P
D000172:Acromegaly / Q000097:blood; D000328:Adult; D002648:Child; D004393:Dwarfism, Pituitary / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects*; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011986:Receptors, Somatotropin / Q000187:drug effects*; D013002:Somatomedins / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects*
D011986:Receptors, Somatotropin; D013002:Somatomedins; D013006:Growth Hormone