[Growth characteristics of adenocarcinoma 755 recurrences in C57Bl/6 and (DBA/2 X C57Bl/6) F1 mouse strains].
Peculiarities of growth and recurrences of the adenocarcinoma 755 are studied in C57Bl/6 mice and hybrids (DBA/2 X +C57Bl/6)F1 after chemotherapy with cyclophosphamide and 6-mercaptopurine (6-MP). The growth rate of tumours was practically identical in the both mice strains. Growth rate of recurrences was slower in examined lines than in corresponding tumours. The obtained results showed that the antitumour effect of the drugs, in particularly of 6-MP, and the growth rate of the first and that of the second recurrences clearly depended on the tumour host strain.
Soliakova
T I
TI
Kiseleva
E G
EG
Iakushchenko
T N
TN
Konovalova
N P
NP
D000230:Adenocarcinoma / Q000188:drug therapy / Q000503:physiopathology*; D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005260:Female; D015122:Mercaptopurine / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000503:physiopathology*; D009368:Neoplasm Transplantation; D013997:Time Factors
D003520:Cyclophosphamide; D015122:Mercaptopurine
Osobennosti rosta retsidivov adenokartsinomy 755 u mysheĭ liniĭ C57Bl/6 i (DBA/2 X C57Bl/6) F1.