[Plasma histamine level in the pulmonary vein immediately following the bolus injection of high-dose heparin in the right atrium. A study carried out during aortocoronary bypass surgery].
This study demonstrates a very rapid and short-lasting elevation of plasma histamine concentrations after heparin injection prior to cannulation for extracorporeal circulation during cardiac surgery. Plasma histamine concentrations increased significantly for less than 1 min following bolus injection of heparin into the right atrium. Blood samples were taken from the distal pulmonary vascular bed, i.e. the pulmonary vein. The design of the study enabled us to observe the development of plasma histamine concentrations within very short time intervals and to detect the high peak plasma histamine concentration that may occur, primarily in the pulmonary outstream vessels. Therefore, the histamine found here could originate from intrathoracically located mast cells. It is more likely, however, that the histamine was administered together with the heparin in complex binding, due to purification problems. The amount of histamine found in this study was sufficient to produce mild to severe circulatory effects in all patients receiving a high dose of heparin.
Adt
M
M
Institut für Anaesthesiologie, Deutsches Herzzentrum Berlin.
Reimann
H J
HJ
Weinhold
C
C
Weigand
R
R
Schmucker
P
P
Kemkes
B M
BM
D001026:Coronary Artery Bypass; D006321:Heart / Q000187:drug effects*; D006493:Heparin / Q000008:administration & dosage*; D006632:Histamine / Q000097:blood*; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D011667:Pulmonary Veins
D006632:Histamine; D006493:Heparin
Plasmahistaminspiegel in der Vena pulmonalis unmittelbar nach Bolusinjektion einer hohen Heparindosis in den rechten Vorhof. Eine Untersuchung während aortokoronaren Bypass-Operationen.