title: Repetitive weekly cycles of recombinant human interleukin-2: responses of renal carcinoma with acceptable toxicity.
abstract: A phase I trial of repetitive weekly cycles of human recombinant interleukin-2 (IL-2) was performed in 23 patients with metastatic carcinoma. Patients received 4 days of IL-2 each week, followed by 3 days of observation, for 4 consecutive weeks. IL-2 was administered iv at 1.0 or 3.0 X 10(6) U/m2/day by one of three schedules involving continuous or bolus infusions. All treatment was carried out in a general hospital ward without intensive care unit monitoring or support. Seventeen patients had metastatic renal cell carcinoma; three of these demonstrated measurable (greater than 50% shrinkage) partial responses. This study demonstrates that IL-2 given alone without lymphokine-activated killer cells in this manner can induce antitumor effects with acceptable toxicity.
authors.affiliation: Department of Human Oncology, University of Wisconsin, Madison.
authors.forename: J A
authors.initials: JA
authors.lastname: Sosman
authors.forename: P C
authors.initials: PC
authors.lastname: Kohler
authors.forename: J
authors.initials: J
authors.lastname: Hank
authors.forename: K H
authors.initials: KH
authors.lastname: Moore
authors.forename: R
authors.initials: R
authors.lastname: Bechhofer
authors.forename: B
authors.initials: B
authors.lastname: Storer
authors.forename: P M
authors.initials: PM
authors.lastname: Sondel
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000556:secondary / Q000628:therapy; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000628:therapy*; D008297:Male; D008545:Melanoma / Q000556:secondary / Q000628:therapy; D008875:Middle Aged
chemical_list: D007376:Interleukin-2