Gene encoding human p250 T-cell activation antigen maps to human chromosome 11.
Human p250 T-cell activation antigen detected by a monoclonal antibody, B1.19.2, is a single peptide antigen with a molecular weight of 250 kilodaltons and is classified serologically into cluster of differentiation, CDw26. Concordance between the presence of human chromosome 11 and the reactivity with B1.19.2 was demonstrated by chromosomal analysis of 23 clones derived from three hybrid series obtained from the fusion of human activated lymphocytes or T-cell chronic lymphocytic leukemia cells and BW5147 mouse T-cell leukemic cells. The results indicated that the presence of chromosome 11 was essential for the expression of p250 T-cell activation antigen. Moreover, the gene for this antigen was assigned to chromosome 11pter----p11.2 by analysis of the hybrid clones retaining the translocated chromosome of 11.
Akao
Y
Y
Department of Internal Medicine, Branch Hospital, Nagoya University School of Medicine, Japan.
Utsumi
K R
KR
Naito
K
K
Ueda
R
R
Takahashi
T
T
Yamada
K
K
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D007621:Karyotyping; D051379:Mice
D000945:Antigens, Differentiation, T-Lymphocyte; D005819:Genetic Markers