[Effect of diucifon on the natural cytotoxic activity of splenic cells in old rats].
The results of comparative investigation of diucifon effect on the level of natural killer cell activity in young and old mice are presented. An increase in the natural cytotoxic activity, as indicated by 51Cr-release micro-test, was considerably higher in old than in young mice during 1-3 days after diucifon administration. However, after diucifon stimulation the level of natural killer cell activity in old mice was significantly lower than in intact young mice.
Totibadze
N V
NV
Suleĭmanova
N S
NS
Van'ko
L V
LV
Fisenko
A P
AP
Sukhikh
G T
GT
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000375:Aging / Q000187:drug effects* / Q000276:immunology; D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D004338:Drug Combinations / Q000494:pharmacology; D007376:Interleukin-2 / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects* / Q000276:immunology; D013450:Sulfones / Q000494:pharmacology*; D013997:Time Factors; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D007376:Interleukin-2; D013450:Sulfones; D003208:Concanavalin A; C023367:diucifon; D014498:Uracil
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