title: Acute monoblastic leukemia with osteosclerosis and extensive myelofibrosis.
abstract: A 4-month-old infant was admitted with a monoblastic infiltration of the skin associated with osteosclerosis. Both lesions spontaneously disappeared within a few months, but 2 years later, a monoblastic leukemia occurred that was associated with marked skin erythema and myelofibrosis. Skin and bone marrow specimens showed a monoblastic infiltration with numerous intermingled mast cells of normal appearance. Whether myelofibrosis was a feature of a systemic mastocytosis or of the leukemic process is discussed in this case.
authors.affiliation: Department of Pathology, Hôpital Calmette, Lille, France.
authors.forename: A
authors.initials: A
authors.lastname: Janin
authors.forename: B
authors.initials: B
authors.lastname: Nelken
authors.forename: S
authors.initials: S
authors.lastname: Dufour
authors.forename: M C
authors.initials: MC
authors.lastname: Sault
authors.forename: O
authors.initials: O
authors.lastname: Taboureau
authors.forename: M
authors.initials: M
authors.lastname: Zandecki
authors.forename: B
authors.initials: B
authors.lastname: Gosselin
mesh_terms: D006801:Humans; D007223:Infant; D007948:Leukemia, Monocytic, Acute / Q000473:pathology*; D008297:Male; D009365:Neoplasm Regression, Spontaneous; D010026:Osteosclerosis / Q000209:etiology*; D055728:Primary Myelofibrosis / Q000209:etiology*