title: [The pharmacokinetics of light-protective agents by photoacoustic spectroscopy].
abstract: We report on in vivo investigations by photoacoustic spectroscopy on the liberation and horny-layer penetration of UV-absorbing drugs from topically applied vehicle films. This spectroscopic technique can be used to determine the absorption of light in the skin with a depth resolution adequate for the 12-microns-thick horny layer and to gain information on temporal variations in the concentration profile of drug penetrating into the horny layer. Experimental results are presented for the UV-absorbing drugs Uvinul T 150 and P 25 applied to the skin in different vehicles. The results are discussed with reference to model calculations demonstrating the influence of different rate-determining steps on temporal variations in concentration profiles.
authors.affiliation: Universität-Hautklinik Göttingen, Abteilung Dermatologie und Venerologie.
authors.forename: K F
authors.initials: KF
authors.lastname: Kölmel
authors.forename: B
authors.initials: B
authors.lastname: Sennhenn
authors.forename: M
authors.initials: M
authors.lastname: Rohr
authors.forename: K
authors.initials: K
authors.lastname: Giese
mesh_terms: D004305:Dose-Response Relationship, Drug; D006801:Humans; D009930:Organic Chemicals; D012815:Signal Processing, Computer-Assisted; D012869:Skin Absorption; D013054:Spectrophotometry, Atomic / Q000295:instrumentation*; D013473:Sunscreening Agents / Q000493:pharmacokinetics*
chemical_list: D009930:Organic Chemicals; D013473:Sunscreening Agents; C059256:Uvinul T 150
vernacular_title: Untersuchungen zur Pharmakokinetik von Lichtschutzsubstanzen durch photoakustische Spektroskopie.