Effect of amoxicillin, cephalexin, and tetracycline-HCl on intestinal L-leucine transport in the rat in vivo.
By utilising an in vivo technique the effects of amoxicillin, cephalexin, and tetracycline-HCl on intestinal L-leucine absorption were studied in the rat. The results showed that amoxicillin caused a time-dependent and reversible inhibition of L-leucine transport while the inhibition induced by the other two antibiotics tested was not reversible. Light microscopic studies revealed that the three antibiotics were without effect on intestinal mucosal morphology.
Barcina
Y
Y
Depto Fisiología Animal, Facultad de Farmacia, Universida de Navarra, Pamplona, Spain.
Ilundain
A
A
Larralde
J
J
D000658:Amoxicillin / Q000494:pharmacology*; D000818:Animals; D002506:Cephalexin / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000166:cytology / Q000502:physiology; D007930:Leucine / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013754:Tetracyclines / Q000494:pharmacology*; D013997:Time Factors
D013754:Tetracyclines; D000658:Amoxicillin; D007930:Leucine; D002506:Cephalexin