MIBG and catecholamine storage in the brain: an in-vitro study.
The uptake and release of mIBG, a tracer of the monoamine uptake and storage function, were studied on superfused rat cerebral cortex sections. mIBG was taken up and released by a mechanism comparable to that of norepinephrine (NE), but this storage appeared to be less specific for mIBG than for NE. This implies that when mIBG is used as a scintigraphic tracer of monoaminergic synaptic vesicles, imaging should be delayed long enough to ensure release of the molecule from its nonspecific binding sites.
Guilloteau
D
D
Unité INSERM U316, Laboratoire de Biophysique Médicale, U.E.R. de Médecine, Tours, France.
Huguet
F
F
Chalon
S
S
Baulieu
J L
JL
Gerard
P
P
Narcisse
G
G
Pourcelot
L
L
Besnard
J C
JC
D019797:3-Iodobenzylguanidine; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000493:pharmacokinetics*; D009638:Norepinephrine / Q000493:pharmacokinetics*; D051381:Rats; D014316:Tritium
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D014316:Tritium; D019797:3-Iodobenzylguanidine; D009638:Norepinephrine