Pachydermoperiostosis with gastric hypertrophy, anemia, and increased serum bone Gla-protein levels.
We evaluated a patient in whom pachydermoperiostosis occurred in conjunction with anemia and gastric hypertrophy. The mechanism of the anemia appears multifactorial because, besides a myelofibrosis, a serum inhibitor of the late stage of erythropoiesis was detected. The elevated serum bone Gla-protein (osteocalcin) favors the hypothesis that primary hypertrophic osteoarthropathy represents an imbalance between increased osteoblastic bone formation and normal bone resorption.
Venencie
P Y
PY
Unité de Dermatologie, Centre Hospitalier Universitaire, Bicêtre, France.
Boffa
G A
GA
Delmas
P D
PD
Verola
O
O
Benkaïdali
I
I
Frija
J
J
Pillet
B
B
Puissant
A
A
D000328:Adult; D000740:Anemia / Q000150:complications*; D001706:Biopsy; D002135:Calcium-Binding Proteins / Q000097:blood*; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D006984:Hypertrophy; D008297:Male; D010004:Osteoarthropathy, Primary Hypertrophic / Q000097:blood / Q000150:complications* / Q000235:genetics / Q000473:pathology; D015675:Osteocalcin; D055728:Primary Myelofibrosis / Q000150:complications
D002135:Calcium-Binding Proteins; D015675:Osteocalcin