Identification and characterization of chemoattractants for epidermal cells.
We have detected and partially characterized factors that promote the directed migration of mouse epidermal cells in a modified Boyden chamber assay. Smooth muscle cells grown in culture were found to secrete a potent chemoattractant for epidermal cells. This activity was further characterized and compared to the chemotactic activities found in wound fluid and conditioned medium from 3T3 L1 cells and with interleukin 1. The migration of epidermal cells during wound healing in vivo might be regulated by such factors.
Martinet
N
N
Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, Bethesda, Maryland 20892.
Harne
L A
LA
Grotendorst
G R
GR
D000818:Animals; D002465:Cell Movement; D002478:Cells, Cultured; D002630:Chemotactic Factors / Q000032:analysis*; D003470:Culture Media / Q000032:analysis; D000078404:Epidermal Cells; D005353:Fibronectins / Q000494:pharmacology; D007375:Interleukin-1 / Q000502:physiology; D008297:Male; D051379:Mice; D009130:Muscle, Smooth / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D014945:Wound Healing
D002630:Chemotactic Factors; D003470:Culture Media; D005353:Fibronectins; D007375:Interleukin-1