Minimum effective dose of trimethoprim for urinary tract infection.
Non-pregnant women with urinary tract infection attending a health centre were treated with single doses of 400 mg, 200 mg or 100 mg of trimethoprim. The cure rates for these doses were 100%, 93% and 90%, respectively. In general practice the expected cure rate for this infection treated conventionally over five to seven days is 85-90%. Therefore, 100 mg of trimethoprim is the minimum effective dose for the treatment of urinary tract infection in general practice.
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D000328:Adult; D001437:Bacteriuria / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D014295:Trimethoprim / Q000008:administration & dosage* / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy*
D014295:Trimethoprim