[The dynamics of immunological indicators in the treatment of patients with multiple sclerosis with prednisolone combined with plasmapheresis].
The dynamics of the immunological parameters was studied in 17 patients with multiple sclerosis (MS) who received prednisolone therapy in combination with plasmacytapheresis. The authors measured the counts of blood lymphocytes, T- and B-cells, active, theophylline-sensitive and theophylline-resistant lymphocytes levels of IgA, IgM, and IgG, and of circulating immune complexes. Marked clinical improvement was attained in 9 patients, moderate improvement in 7 cases. The dynamics of the immunological parameters depended on the clinical characteristics of the disease. The best correction of immunological characteristics was observed in patients with exacerbation of the process, remittant course, and moderate severity of the disease. The authors discuss the variable reactivity of theophylline-sensitive lymphocytes to the treatment.
Neretin
V Ia
VIa
Gannushkina
I V
IV
Zhirnova
I G
IG
Sapfirova
V A
VA
Kir'iakov
V A
VA
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology / Q000628:therapy*; D010956:Plasmapheresis; D011239:Prednisolone / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000276:immunology
D007136:Immunoglobulins; D011239:Prednisolone
Dinamika immunologicheskikh pokazateleĭ pri lechenii bol'nykh rasseiannym sklerozom prednizolonom v sochetanii s plazmotsitaferezom.