Synthesis of 11C-methylated inulin as a radiopharmaceutical for imaging brain edema and pulmonary edema.
11C-methylated inulin, supposedly useful for imaging of brain edema and pulmonary edema, was prepared using cyclotron produced 11CO2. The synthesis consists of the production of 11C-methyl iodide and its coupling with inulin alkoxide sodium in dimethylsulfoxide as solvent. 11C labeled inulin was purified by alcohol precipitation. The radiochemical yield of pure 11C-inulin was 34% of 11CO2 30 min after the end of bombardment. The blood clearance and body distribution of 11C was observed in rabbits after i.v. injection of 11C-inulin. The blood clearance curve was composed of a sum of three exponential functions. The gamma camera image showed that the 11C activity in blood moved quickly to kidneys and urine and a small dose of radioactivity remained persistently in edematous tissues, i.e. the edematous lung tissues produced by oleic acid treatment.
Hara
T
T
National Nakano Chest Hospital, Tokyo, Japan.
Iio
M
M
Inagaki
K
K
D000818:Animals; D001929:Brain Edema / Q000000981:diagnostic imaging*; D002250:Carbon Radioisotopes; D005260:Female; D007444:Inulin / Q000138:chemical synthesis; D007553:Isotope Labeling; D011654:Pulmonary Edema / Q000000981:diagnostic imaging*; D011817:Rabbits; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D007444:Inulin