title: Decreased slow-wave sleep and enlarged lateral ventricles in schizophrenia.
abstract: All-night electroencephalogram measures were evaluated against computed tomography scan measures, negative symptoms, and premorbid personality assessment in ten drug-free male schizophrenic patients. Computed tomography scan measures included ventricle brain ratio, cortical atrophy, and width of the third ventricle. Decreased stage-4 sleep was associated with enlarged VBR, poor premorbid functioning, and negative symptoms. Size of the VBR accounted for 58.5% of the variance in stage-4 sleep. Brain atrophy was associated with longer sleep latency but with less arousals once the patients were asleep. Rapid-eye-movement measures did not correlate significantly with any of the variables examined. Our data suggest that decreased slow-wave sleep and ventricle size are associated in schizophrenia.
authors.affiliation: Psychiatry Service, Veterans Administration Medical Center, Pittsburgh, Pennsylvania 15206.
authors.forename: D P
authors.initials: DP
authors.lastname: van Kammen
authors.forename: W B
authors.initials: WB
authors.lastname: van Kammen
authors.forename: J
authors.initials: J
authors.lastname: Peters
authors.forename: K
authors.initials: K
authors.lastname: Goetz
authors.forename: T
authors.initials: T
authors.lastname: Neylan
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D002552:Cerebral Ventricles / Q000473:pathology / Q000503:physiopathology*; D004569:Electroencephalography; D004576:Electromyography; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000473:pathology / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012890:Sleep; D012894:Sleep Stages