title: Expression of T-cell associated antigens by porcine natural killer cells.
abstract: We have examined the cell surface phenotype of porcine natural killer (NK) cells and compared them with classic porcine cytotoxic T lymphocytes (CTL). NK cells were susceptible to treatment with monoclonal antibodies to CD2 (PT11), CD8 (PT8) and Ia plus complement (C), as well as with antiserum to asialo-GM1 (ASGM1) plus C. In addition, monoclonal antibodies to leucocyte function antigen 1 (LFA-1) but not to CD8 blocked NK-mediated lysis in the absence of C. This is in contrast to porcine CTL, which were eliminated by antibodies to CD2, CD8 and Ia plus C, but not by anti-ASGMI plus C, and which were blocked by anti-CD8 in the absence of C. Therefore, although porcine NK cells are similar to porcine CTL, they are distinguished by several important differences.
authors.affiliation: Transplantation Biology Section, National Cancer Institute, Bethesda, Maryland.
authors.forename: M D
authors.initials: MD
authors.lastname: Pescovitz
authors.forename: M A
authors.initials: MA
authors.lastname: Lowman
authors.forename: D H
authors.initials: DH
authors.lastname: Sachs
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D003165:Complement System Proteins / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D007694:Killer Cells, Natural / Q000276:immunology*; D013552:Swine; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D003165:Complement System Proteins