Evaluation of regional differences of tracer appearance time in cerebral tissues using [15O] water and dynamic positron emission tomography.
The tracer appearance time relative to the radial artery-sampling site has been evaluated in six brain locations in five human subjects using dynamic positron emission tomography (PET) following the bolus injection of H2(15)O. There was a maximum difference of +/- 2 s from the average in each location. To globally adjust the timing difference between the measured arterial curve and the PET scan, a correction method was developed based on a nonlinear least-squares fitting procedure. This new technique determined the global time delay with an accuracy of +/- 0.5 s. On the other hand, the linear backward extrapolation method resulted in a systematic error of 4 s.
Iida
H
H
Research Institute for Brain and Blood Vessels, Akita, Japan.
Higano
S
S
Tomura
N
N
Shishido
F
F
Kanno
I
I
Miura
S
S
Murakami
M
M
Takahashi
K
K
Sasaki
H
H
Uemura
K
K
D001921:Brain / Q000378:metabolism*; D006801:Humans; D010104:Oxygen Radioisotopes / Q000493:pharmacokinetics*; D014055:Tomography, Emission-Computed; D014867:Water / Q000493:pharmacokinetics*
D010104:Oxygen Radioisotopes; D014867:Water