Effects of fasting on the myocardial subcellular distribution and lipid distribution of terminal p-iodophenyl-substituted fatty acids in rats.
The myocardial lipid pool distribution and subcellular distribution of radiolabeled methyl-branched fatty acids in rats was evaluated under conditions of fasting (24 h) and feeding. With the unbranched iodophenyl fatty acid, fasting resulted in increased myocardial extraction and clearance time with a decrease in the incorporation into triglycerides and greater radioactivity in the mitochondrial fraction. With the monomethyl-branched analogue, the effects of fasting on lipid and subcellular distribution were minor except for a decrease in triglyceride incorporation. Like the unbranched analogue, the dimethyl-branched iodophenyl fatty acid showed increased myocardial extraction with fasting, however, this structurally-modified fatty acid showed increased rather than decreased incorporation into triglycerides.
Ambrose
K R
KR
Nuclear Medicine Group, Oak Ridge National Laboratory, TN 37831.
Owen
B A
BA
Callahan
A P
AP
Goodman
M M
MM
Knapp
F F
FF
D000818:Animals; D005215:Fasting; D005227:Fatty Acids; D005260:Female; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000493:pharmacokinetics*; D050356:Lipid Metabolism; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344
D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C049338:iodofiltic acid; C049337:15-(4-iodophenyl)-3,3-dimethylpentadecanoic acid; C025391:omega-(4-iodophenyl)pentadecanoic acid