title: [T- and B-cell double lymphoma: immunologic characterization using monoclonal antibodies].
abstract: The coexistence of two non-Hodgkin lymphomas in one patient is extremely rare. We describe a patient who suffered for 17 years from chronic lymphocytic leukemia of B-cell origin with bone marrow and peripheral blood involvement until he developed clinically typical mycosis fungoides of the skin. The neoplastic lymphatic cells in the skin infiltrates were T-cells of the helper/inducer phenotype and thus differed morphologically and by immunological markers from the neoplastic cells in peripheral blood and bone marrow. The clonal B-cell expansion was controlled well over many years by cytotoxic drug therapy, the cutaneous T-cell lymphoma only with limited success by oral photochemotherapy owing to lack of compliance. The patient died 3 years after the diagnosis of MF from a parallel exacerbation of both diseases. Extensive immunohistochemical studies verified the nature of both lymphomas in vivo and at autopsy.
authors.affiliation: I Universitäts-Hauklinik Wien.
authors.forename: W
authors.initials: W
authors.lastname: Aberer
authors.forename: V
authors.initials: V
authors.lastname: Groh
authors.forename: P
authors.initials: P
authors.lastname: Bettelheim
authors.forename: T
authors.initials: T
authors.lastname: Radaszkiewicz
authors.forename: K
authors.initials: K
authors.lastname: Wolff
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*; D013601:T-Lymphocytes
chemical_list: D000911:Antibodies, Monoclonal
vernacular_title: T- und B-Zell-Doppellymphom: immunologische Charakterisierung mittels monoklonaler Antikörper.