title: A circulating thyroid peroxidase-like substance in healthy human peripheral blood.
abstract: Circulating thyroid peroxidase (TPO)-like substance in healthy human peripheral blood was studied to clarify the immunological role of TPO. By using a highly sensitive radioimmunoassay system combined with murine monoclonal antibodies, TPO-like substance was measurable in 6 out of 84 sera. Characterization of this circulating substance by gel filtration revealed that the molecular weight of a major peak corresponded to that of trypsinized TPO. From these findings it is possible that peripheral blood lymphocytes are exposed to a low level of TPO as well as to thyroglobulin.
authors.affiliation: Central Laboratory of Clinical Investigation, Miyazaki Medical College Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kotani
authors.forename: S
authors.initials: S
authors.lastname: Ohtaki
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000097:blood* / Q000145:classification; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
chemical_list: D000911:Antibodies, Monoclonal; D007453:Iodide Peroxidase