Equieffective protection by human and bovine SOD against renal reperfusion damage in rats.
Both hum-SOD and bov-SOD improved the impaired renal function during kidney reperfusion. In the experiments with a 60-min occlusion period the effects of bov-SOD tended to be more pronounced than the effects of hum-SOD, whereas after a 30-min occlusion period the improvement of renal function by hum-SOD was more striking. In essence, therefore, hum-SOD proved to be equipotent to bov-SOD. The apoenzyme (Apo-SOD), lacking the active Cu moiety, virtually did not improve the renal function impairment. Thus, the protective effects of hum-SOD and bov-SOD must be ascribed to the enzymatic function of these proteins.
Schneider
J
J
Grünenthal GmbH, Center of Research, Aachen, FRG.
Friderichs
E
E
Giertz
H
H
D000818:Animals; D001051:Apoenzymes / Q000627:therapeutic use; D002417:Cattle; D006801:Humans; D007511:Ischemia / Q000503:physiopathology*; D007668:Kidney / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000627:therapeutic use*; D012079:Renal Circulation / Q000187:drug effects*; D015427:Reperfusion Injury / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000627:therapeutic use*
D001051:Apoenzymes; D011994:Recombinant Proteins; D013482:Superoxide Dismutase