[Induction of the traits of the differentiated T-cell phenotype in the blast cells of patients with acute lymphoblastic leukemia. I. The expression of T-cell markers as affected by different inducers].
The expression of T-lymphocyte markers has been demonstrated by blast cells of patients with non-T, non-B and pre-T-cell acute lymphoblastic leukaemia (ALL). The main inducing agent is phytohemagglutinin (PHA). Its action was enhanced when combined with phorbol ether (TPA) or ouabain. Dimethylsulfoxide, ouabain and concanavalin A had no similar inducing effect. TPA caused the expression of some T-cell markers revealed by monoclonal antibodies but had only a little inducing effect to E-receptor.
Kazhdan
I Ia
IIa
Tsveĭbakh
A S
AS
Kariagin
I E
IE
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D001853:Bone Marrow / Q000187:drug effects / Q000276:immunology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D008934:Mitogens / Q000494:pharmacology*; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D008934:Mitogens
Induktsiia nekotorykh priznakov differentsirovannogo T-kletochnogo fenotipa u blastnykh kletok bol'nykh ostrym limfoblastnym leĭkozom. I. Ekspressiia T-kletochnykh markerov pod vliianiem razlichnykh induktorov.