Prolactin binding components in prostatic cancer tissue specimens obtained by TURP.
The concentration of unoccupied prolactin binding components was measured in 11 prostatic malignant tissue specimens obtained by TURP. Prolactin labeled with 125I binds specifically to mitochondrial and microsomal membrane subcompartments in some well- and medium-differentiated prostate cancer structures (67 and 50% of tumors, respectively). All the examined low-differentiated prostatic cancers (4/4) were found to be receptor-poor tissues. Thermal stability of prolactin binding components in tissues stored for 45 days at -30 degrees C is satisfactory and apparently is significantly greater than that of prostatic androgen receptors.
Tarle
M
M
Nuclear Medicine and Oncology Clinic, Clinical Hospital Dr. M. Stojanovic, Croatia, Yugoslavia.
D006358:Hot Temperature; D006801:Humans; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000378:metabolism; D008297:Male; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000032:analysis* / Q000601:surgery; D011981:Receptors, Prolactin / Q000032:analysis* / Q000378:metabolism; D014021:Tissue Preservation
D011981:Receptors, Prolactin