Histometric investigations of the effect of cyclosporin A on the testicular tissue of rats.
The effect of cyclosporin A (CsA) on rat testes was assessed in Lewis rats which were given 10 mg/kg of CsA im per day. The rats were divided into 13 subgroups, and 1 subgroup was sacrificed each month. The rat testes were measured and examined for histometrical and morphological changes in comparison to controls. Histometrical analysis included testicular cross-sectional surface area, tubular density, tubular diameter, and the amounts of testicular germinal epithelium, lumen, and interstitial tissue. In the parameters examined, there were no overall differences between CsA-treated animals and controls. CsA does not affect rat testicular tissue.
Chen
C
C
Department of Surgery, School of Medicine, University of California, San Diego 92103.
Scott
M H
MH
Wolf
P L
PL
Moossa
A R
AR
Lee
S
S
D000367:Age Factors; D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D011917:Rats, Inbred Lew; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects*
D003524:Cyclosporins