title: Granulomatous Pneumocystis carinii pneumonia in three patients with the acquired immune deficiency syndrome.
abstract: Pneumocystis carinii pneumonia is a frequent manifestation of the acquired immune deficiency syndrome (AIDS). It usually presents radiologically as diffuse bilateral infiltrates and histologically as a foamy, eosinophilic intra-alveolar exudate containing the organisms' cysts. We recently studied two rare cases of P carinii pneumonia presenting as pulmonary nodules on chest x-ray films in two patients with AIDS. The corresponding histologies were a combination of the usual intra-alveolar pattern, with an alveolar and interstitial granulomatous appearance. Pneumocystis carinii was present in both areas and was the only organism found in the tissues examined. A third case presented with the more common radiographic appearance but also had a granulomatous histology. We conclude that P carinii pneumonia should be considered in the differential diagnosis of pulmonary nodules in immunocompromised patients and that pathologists should be aware of the possibility of a granulomatous reaction to this organism.
authors.affiliation: Department of Pathology, Mt Sinai Medical Center, New York, New York 10029.
authors.forename: I J
authors.initials: IJ
authors.lastname: Bleiweiss
authors.forename: J S
authors.initials: JS
authors.lastname: Jagirdar
authors.forename: M J
authors.initials: MJ
authors.lastname: Klein
authors.forename: J L
authors.initials: JL
authors.lastname: Siegel
authors.forename: D J
authors.initials: DJ
authors.lastname: Krellenstein
authors.forename: A R
authors.initials: AR
authors.lastname: Gribetz
authors.forename: J A
authors.initials: JA
authors.lastname: Strauchen
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D005260:Female; D006099:Granuloma / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed