Effects of the novel compound NIK-247 on impairment of passive avoidance response in mice.
The effects of NIK-247 [9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta(b)-quinoline monohydrate hydrochloride] were studied on a model involving various types of drug- and electroconvulsive shock (ECS)-induced amnesia. The step-down type passive avoidance task in mice was used for comparison of the effects with those of tacrine, a 4-aminopyridine derivative which has an antiamnesic action. NIK-247 administered pre- and post-training or pre-retention test (24 h after training) prevented the disruption of memory induced by cycloheximide administered immediately after training. In addition, NIK-247 protected from the amnesia induced by treatment with ECS, phencyclidine and picrotoxin immediately after training. Tacrine failed to protect from ECS- and PCP-induced amnesia at the doses effective on cycloheximide-induced amnesia. The results indicate that NIK-247 improves cognitive functions at different phases of the learning and memory processes such as acquisition, consolidation, and retrieval in drug- and ECS-induced amnesia. NIK-247 may produce its antiamnesic effects via the cholinergic and GABAergic neuronal systems.
Nabeshima
T
T
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Yoshida
S
S
Kameyama
T
T
D000634:Aminoquinolines / Q000494:pharmacology*; D000647:Amnesia / Q000209:etiology / Q000517:prevention & control; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D002794:Choline / Q000494:pharmacology; D002800:Cholinesterase Inhibitors; D003513:Cycloheximide; D004597:Electroshock; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D051379:Mice; D010622:Phencyclidine; D010852:Picrotoxin; D013619:Tacrine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D000634:Aminoquinolines; D002794:Choline; D002800:Cholinesterase Inhibitors; D003513:Cycloheximide; D010622:Phencyclidine; D010852:Picrotoxin; D013619:Tacrine; D005680:gamma-Aminobutyric Acid; C049860:amiridine