Chemical-analytical characterization of dihydroambazone.
Important properties of p-(thiosemicarbazido)diamino-methylen-hydrazino benzene (1; dihydroambazone) are described. The transformation of this compound into 1,4-benzoquinone guanylhydrazone thiosemicarbazone (2; ambazone) dependent on different aqueous buffer systems was investigated. The spectroscopic behaviour of the transformation product allows us to determine the content of the compound in aqueous solutions, whereas the determination in serum is much more difficult. Furthermore, TLC experiments and oxidation methods are described.
Miosga
N
N
Akademie der Wissenschaften der DDR, Zentralinstitut für Mikrobiologie und Experimentelle Therapie, Jena.
Schulze
W
W
Hesse
G
G
Römer
W
W
D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008935:Mitoguazone / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood; D010084:Oxidation-Reduction; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet
D012997:Solvents; C058853:dihydroambazone; D008935:Mitoguazone