No male segregation distortion of DR2 haplotypes in Japanese narcoleptic patients.
Segregation of narcolepsy-associated DR2/DQw1 haplotypes was studied in 19 informative Japanese families. Each family consisted of a DR2-heterozygous patient, his or her spouse, and their children. In contrast to the previous study on Caucasian narcolepsy, no segregation distortion of the DR2/DQw1 haplotype was observed. The DR2/DQw1 haplotypes were inherited by 9 of 22 offspring from fathers (41%, p = 0.54) and by 10 of 14 offspring from mothers (71%, p = 0.16). These data show that there is no significant segregation distortion of the DR2/DQw1 haplotype in Japanese patients with narcolepsy.
Matsuki
K
K
Blood Transfusion Service, Tokyo University Hospital, Japan.
Juji
T
T
Honda
Y
Y
D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics*; D015802:HLA-DR2 Antigen; D006239:Haplotypes; D006801:Humans; D007564:Japan; D008297:Male; D009290:Narcolepsy / Q000235:genetics / Q000276:immunology*; D012737:Sex Factors
D006683:HLA-DQ Antigens; C051568:HLA-DQ1 antigen; D006684:HLA-DR Antigens; D015802:HLA-DR2 Antigen