title: Studies on metabolic pathways of cyanate in rats.
abstract: Metabolic pathways of cyanate in rats were studied by means of measurements of cyanate, carbamyl phosphate and S-carbamyl group. Approximately 30-50% of cyanate administered to rats (0.5 mmol/kg body weight) was found in buffered gastric contents, and was also detected as ammonia liberated by acid hydrolysis. However, the gastric excretion of cyanate was a temporary phenomenon just after cyanate administration. Biliary and urinary excretion of cyanate and acid-soluble S-carbamyl group are minor metabolic pathways.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chiba University, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Koshiishi
authors.forename: R
authors.initials: R
authors.lastname: Shibayama
authors.forename: Y
authors.initials: Y
authors.lastname: Morimoto
authors.forename: T
authors.initials: T
authors.lastname: Imanari
mesh_terms: D000818:Animals; D001646:Bile / Q000032:analysis; D002221:Carbamyl Phosphate / Q000493:pharmacokinetics / Q000652:urine; D003485:Cyanates / Q000493:pharmacokinetics* / Q000652:urine; D005753:Gastric Mucosa / Q000378:metabolism; D006868:Hydrolysis; D008099:Liver / Q000378:metabolism; D051381:Rats
chemical_list: D003485:Cyanates; D002221:Carbamyl Phosphate