Analysis of consecutive pseudo-first-order reactions. I: An evaluation of available methods to calculate the rate constants from co-product or co-reactant data.
Co-product or co-reactant data is commonly used to obtain the hydrolysis rate constants for two-step consecutive pseudo-first-order reactions. Different methods to calculate the rate constants from experimental data were evaluated using data simulated with and without a +/- 2% random error. The results of this analysis indicate that the ability to determine the value and accuracy of the rate constants obtained by the different methods depends on the k2/k1 ratio. In certain ranges of k2/k1 ratios, erroneous results are obtained which have occasionally led to incorrect conclusions by authors in the literature.
Kalonia
D S
DS
School of Pharmacy, University of Connecticut, Storrs 06268.
Simonelli
A P
AP
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003198:Computer Simulation; D007700:Kinetics; D008956:Models, Chemical