Dose-dependent induction of anti-native DNA antibodies in cats by propylthiouracil.
Cats receiving propylthiouracil (PTU) develop antinuclear antibodies (ANA) and an immune-mediated disease syndrome characterized by anorexia, lymphadenopathy, weight loss, and Coombs-positive hemolytic anemia. Investigation of the ANA specificity indicated that the predominant ANA activity consistent of anti-native DNA (nDNA) antibodies. The formation of anti-nDNA antibodies and immune-mediated disease syndrome appeared to be dose-dependent, even in cats in which a response had been induced on 4 prior occasions. These results supply further evidence that PTU-induced autoimmunity is not the result of a simple drug allergy. Rather, it appears that PTU induces a lupus-like syndrome, including the hallmark sign of systemic lupus erythematosus, anti-nDNA antibodies.
Aucoin
D P
DP
North Carolina State University, School of Veterinary Medicine, Raleigh 27606.
Rubin
R L
RL
Peterson
M E
ME
Reidenberg
M M
MM
Drayer
D E
DE
Hurvitz
A I
AI
Lahita
R G
RG
D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis / Q000276:immunology*; D000918:Antibody Specificity; D002415:Cats; D004247:DNA / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D007154:Immune System Diseases / Q000139:chemically induced; D011441:Propylthiouracil / Q000276:immunology* / Q000494:pharmacology
D000974:Antibodies, Antinuclear; D011441:Propylthiouracil; D004247:DNA