Effectiveness of enteric-coated preparations on nutritional parameters in cystic fibrosis. A long-term study.
To evaluate the effectiveness of enteric-coated pancreatic enzyme supplements in comparison to conventional preparations of ingested enzyme on growth and nutritional parameters of patients with cystic fibrosis, we conducted a long-term study involving 40 patients. The data reproduced here were recorded after 6 months of therapy with powder-containing capsules or with enteric-coated products. Fat absorption was estimated by measurement of steatorrhoea with the steatocrit method. All parameters studied improved after enteric-coated pancreatic enzyme therapy, with a statistically significant increase in weight, cholesterol and haemoglobin values. Furthermore, the number of patients with positive steatocrit test was lower after therapy with enteric-coated enzyme supplementation. These findings suggest that the enteric-coated product not only reduces steatorrhoea, but above all improves the nutritional parameters and growth of patients affected by cystic fibrosis.
Carroccio
A
A
Cattedra di Patologia Medica, Università di Palermo, Italia.
Pardo
F
F
Montalto
G
G
Japichino
L
L
Iacono
G
G
Collura
M
M
Notarbartolo
A
A
D000293:Adolescent; D000328:Adult; D001774:Blood Chemical Analysis; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D009752:Nutritional Status / Q000187:drug effects*; D010194:Pancreatin / Q000008:administration & dosage / Q000627:therapeutic use*; D013608:Tablets, Enteric-Coated
D013608:Tablets, Enteric-Coated; D010194:Pancreatin