title: Immunohistochemical analysis of thiol: protein disulfide oxidoreductase in hypothalamic neurons of Brattleboro rat.
abstract: The immunolocalization of thiol: protein disulfide oxidoreductase (TPO) in CNS of Wistar rats and homozygous Brattleboro rats was investigated by use of monospecific antiserum and Sternberger's unlabelled immunoenzyme technique. It was revealed that TPO is present in hypothalamic neurons belonging to nucleus supraopticus and paraventricularis. The number of immunopositive nerve cells was reduced in Brattleboro rats as compared to Wistar rats. It was concluded that TPO must have tasks in CNS unrelated to the management of vasopressin production and/or processing.
authors.affiliation: Institute of Anatomy, Medical Academy Magdeburg, Czechoslovakia.
authors.forename: H G
authors.initials: HG
authors.lastname: Bernstein
authors.forename: S
authors.initials: S
authors.lastname: Ansorge
authors.forename: V
authors.initials: V
authors.lastname: Nováková
authors.forename: M
authors.initials: M
authors.lastname: Reiser
authors.forename: A
authors.initials: A
authors.lastname: Dorn
mesh_terms: D000818:Animals; D005260:Female; D054477:Glutaredoxins; D007031:Hypothalamus / Q000201:enzymology*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000201:enzymology*; D010088:Oxidoreductases / Q000032:analysis*; D011490:Protein Disulfide Reductase (Glutathione); D051381:Rats; D011910:Rats, Brattleboro; D011919:Rats, Inbred Strains; D013045:Species Specificity
chemical_list: D054477:Glutaredoxins; D010088:Oxidoreductases; D011490:Protein Disulfide Reductase (Glutathione)