title: Bile acid malabsorption demonstrated by SeHCAT in chronic diarrhoea, with special reference to the impact of cholecystectomy.
abstract: SeHCAT is a gamma-labelled synthetic bile acid, suitable for external measurements and detection of bile acid malabsorption. In this study 138 subjects were investigated with 75SeHCAT. The technique was modified by calculating the biologic half-life of the isotope (WBR-50) within 48 h. All patients with ileocaecal resection had reduced WBR-50 values, as did most (8 of 12) with Crohn's disease affecting the small bowel. Among patients with chronic diarrhoea 24 out of 62 patients had reduced WBR-50 values. Four of the patients with low WBR-50 and one in the group with normal WBR-50 had previously been cholecystectomized. In a consecutive study, 15 patients were investigated before and after cholecystectomy. In 12, WBR-50 decreased after the operation (p less than 0.05). The results demonstrate the impact of cholecystectomy on the interpretation of the SeHCAT retention results. The results may also add to the understanding of diarrhoea secondary to cholecystectomy.
authors.affiliation: Dept. of Medicine, University Hospital, Umeå, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Suhr
authors.forename: A
authors.initials: A
authors.lastname: Danielsson
authors.forename: H
authors.initials: H
authors.lastname: Nyhlin
authors.forename: H
authors.initials: H
authors.lastname: Truedsson
mesh_terms: D000328:Adult; D001647:Bile Acids and Salts / Q000378:metabolism*; D002432:Cecum / Q000601:surgery; D002763:Cholecystectomy / Q000009:adverse effects*; D002908:Chronic Disease; D003967:Diarrhea / Q000209:etiology*; D006801:Humans; D007082:Ileum / Q000601:surgery; D012644:Selenium Radioisotopes; D013656:Taurocholic Acid / Q000031:analogs & derivatives*
chemical_list: D001647:Bile Acids and Salts; D012644:Selenium Radioisotopes; D013656:Taurocholic Acid; C033638:23-seleno-25-homotaurocholic acid