Morphine-induced immunomodulation is not related to serum morphine concentrations.
Morphine pellets produced atrophy of the spleen and thymus and affected mitogen-induced lymphocyte proliferation in mice as characterized by marked suppression of concanavalin A-induced blastogenesis at 48 h, and mild stimulation at 120 h. Morphine blood levels in these animals indicated that changes in the immunomodulatory effects of morphine over time were not related to dramatic shifts in circulating morphine. Enclosure of the pellet in nylon mesh did not alter blood levels or morphine-induced immunomodulation.
Bryant
H U
HU
Department of Medical Neuroscience, Walter Reed Army Institute of Research, Washington, DC 20307.
Yoburn
B C
BC
Inturrisi
C E
CE
Bernton
E W
EW
Holaday
J W
JW
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D007109:Immunity / Q000187:drug effects*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009020:Morphine / Q000097:blood / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects
D009020:Morphine