Effect of furazolidone and nitrofurazone on brain gamma-amino butyric acid and glutamate concentrations in chickens.
1. The concentrations of gamma-amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, birds on the small dose of FZ or NF lost about 9% of their bodyweight, and those on the high doses lost about 18%. 3. Both drugs produced dose-dependent increases in the concentrations of GAA and glutamate which were statistically significant at doses of 25 and 50 mg/kg of NF and 50 mg/kg of FZ.
Ali
B H
BH
Department of Veterinary Medicine, Pharmacology and Toxicology, University of Khartoum, Sudan.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002645:Chickens; D005664:Furazolidone / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009583:Nitrofurazone / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005971:Glutamates; D005680:gamma-Aminobutyric Acid; D005664:Furazolidone; D009583:Nitrofurazone