title: Treatment of hypopituitarism with recombinant somatropin for 1 year.
abstract: Twenty-five hypopituitary patients were treated with recombinant somatropin for 1 year at a dosage of 0.5 IU/kg/week. In previously untreated patients (n = 16), heights increased by between 4.5 and 10.2 cm, with a mean height velocity of 7.7 +/- 1.8 cm/year (mean +/- SD). In previously treated patients (n = 9), heights increased by between 3.9 and 7.6 cm, with a mean height velocity of 5.8 +/- 1.0 cm/year, similar to that observed during previous treatment with pituitary GH. Anti-GH antibodies were observed in two patients at a low titre. The antibodies disappeared in one patient during the treatment. These data indicate that recombinant somatropin has a growth promoting effect and low immunogenicity.
authors.affiliation: Committee for Treatment of Pituitary Dwarfism, Foundation for Growth Science in Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takano
authors.forename: K
authors.initials: K
authors.lastname: Shizume
authors.forename: I
authors.initials: I
authors.lastname: Hibi
authors.forename: A
authors.initials: A
authors.lastname: Okuno
authors.forename: K
authors.initials: K
authors.lastname: Hanyu
authors.forename: S
authors.initials: S
authors.lastname: Suwa
authors.forename: H
authors.initials: H
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Kondo
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: N
authors.initials: N
authors.lastname: Iwatani
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton; D000917:Antibody Formation; D001827:Body Height / Q000187:drug effects; D002648:Child; D005260:Female; D013006:Growth Hormone / Q000172:deficiency / Q000276:immunology / Q000627:therapeutic use*; D006801:Humans; D007018:Hypopituitarism / Q000188:drug therapy*; D008297:Male; D011994:Recombinant Proteins
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone