The effects of recombinant CSF-1 on the blast cells of acute myeloblastic leukemia in suspension culture.
Recombinant hemopoietic colony-stimulating factors (CSFs), including GM-CSF, G-CSF and IL-3, have been shown to be effective stimulators of both self-renewal and terminal differentiation of blast stem cells in acute myeloblastic leukemia (AML). We have examined the activity of a fourth growth factor, recombinant CSF-1 (or M-CSF), on the growth of leukemic blasts in culture. CSF-1 was found to be active on some, but not all, blast populations. In sensitive cells, CSF-1 often stimulated the production of adherent blast cells incapable of division. This observation leads us to suggest that CSF-1 may be useful in the treatment of selected cases of AML.
Miyauchi
J
J
Ontario Cancer Institute, Toronto, Canada.
Wang
C
C
Kelleher
C A
CA
Wong
G G
GG
Clark
S C
SC
Minden
M D
MD
McCulloch
E A
EA
D000328:Adult; D000368:Aged; D001752:Blast Crisis / Q000473:pathology*; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D008962:Models, Theoretical; D011994:Recombinant Proteins / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014410:Tumor Stem Cell Assay
D003115:Colony-Stimulating Factors; D011994:Recombinant Proteins