[Klofelin intensification of the analgesic effect of ketamine and its influence on the nociceptive reaction of the arterial pressure].
Clonidine was found to potentiate the analgesic effect of ketamine and to inhibit nociceptive hemodynamic reactions in wakeful animals. It is assumed that opiate mechanisms do not underlie the analgesic and autonomotropic effects of clonidine and ketamine combination.
Panov
A V
AV
Vetsheva
M S
MS
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003000:Clonidine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D007649:Ketamine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009619:Nociceptors / Q000187:drug effects* / Q000502:physiology; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D014828:Vocalization, Animal / Q000187:drug effects / Q000502:physiology; D015016:Yohimbine / Q000494:pharmacology
D000700:Analgesics; D015016:Yohimbine; D009270:Naloxone; D007649:Ketamine; D003000:Clonidine; D011224:Prazosin
Usilenie klofelinom anal'geticheskogo éffekta ketamina i ego vliianie na notsitseptivnye reaktsii arterial'nogo davleniia.