title: Suppressions of ischemic paw oedema in mice, rats and guinea pigs by superoxide dismutases from different sources.
abstract: Various sources of superoxide dismutases (SOD) suppressed ischaemic paw oedemata (tourniquet poditis) of mice, rats and guinea pigs with different potencies. Intravenous (i.v.) dosing of mouse Cu,Zn-SOD had no effect on mouse ischaemic oedema, yet rat and guinea pig Cu,Zn-SOD suppressed ischaemic oedemata of rats and guinea pigs. Homologous SOD was anti-inflammatory at least in these two models. Guinea pig SOD was one of the most potent in all models, but showed a very narrow range of effective dose. This bell-shape suppressive pattern was ameliorated by concomitant catalase injection. Bovine and human Cu,Zn-SOD had a rather broad range of effective dose. Bacterial Mn-SODs were suppressive in mice, as well as the oxygen radical scavenger MK-447 and cytochrome c. Dexamethasone was effective only when administered more than 3 hrs in advance. As ischaemic paw oedema of mice was not sensitive to cyclooxygenase and lipoxygenase inhibitors, this model could serve for screening new types of anti-inflammatory or anti-ischaemic drugs.
authors.affiliation: Research Laboratories of Fujisawa Pharmaceutical Co., Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Oyanagui
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Okajima
mesh_terms: D000818:Animals; D002417:Cattle; D004487:Edema / Q000209:etiology / Q000517:prevention & control*; D004912:Erythrocytes / Q000201:enzymology; D006168:Guinea Pigs; D006614:Hindlimb / Q000098:blood supply; D006801:Humans; D007275:Injections, Intravenous; D007511:Ischemia / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013045:Species Specificity; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*
chemical_list: D013482:Superoxide Dismutase