Biological activities of deoxyspergualin in autoimmune disease mice.
An assessment of the prophylactic and ameliorative effects of deoxyspergualin (NKT-01), an immunosuppressive agent, was carried out in male MRL/MpJ-lpr/lpr (MRL/1) mice which spontaneously develop lupus-like lesions. When NKT-01 was administered ip daily from the age of either 8 or 19 weeks, diseases such as massive lymphadenopathy, circulating anti-DNA antibody and lupus nephritis were markedly suppressed. The primary response to lipopolysaccharide was significantly reduced in MRL/1 mice administered NKT-01 but the response to sheep red blood cells was not affected. The ability of spleen cells to release interleukins 2 and 3 with or without mitogen was significantly enhanced in mice receiving NKT-01. These findings demonstrate that NKT-01 has therapeutic activity against the development of spontaneous disease in MRL/1 mice.
Nemoto
K
K
Research Laboratories, Pharmaceuticals Group, Nippon Kayaku Co., Ltd., Tokyo, Japan.
Hayashi
M
M
Sugawara
Y
Y
Ito
J
J
Abe
F
F
Takita
T
T
Nakamura
T
T
Takeuchi
T
T
D000818:Animals; D000880:Anthraquinones / Q000302:isolation & purification / Q000494:pharmacology; D000974:Antibodies, Antinuclear / Q000096:biosynthesis; D001327:Autoimmune Diseases / Q000276:immunology / Q000517:prevention & control*; D004353:Drug Evaluation, Preclinical; D004797:Enzyme-Linked Immunosorbent Assay; D006146:Guanidines / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008181:Lupus Nephritis / Q000276:immunology / Q000517:prevention & control; D008297:Male; D051379:Mice; D000095602:Angucyclines and Angucyclinones
D000880:Anthraquinones; D000974:Antibodies, Antinuclear; D006146:Guanidines; D007166:Immunosuppressive Agents; C059960:MM 47755; D000095602:Angucyclines and Angucyclinones; C057570:8-O-methylrabelomycin; C037258:gusperimus