[Synthesis and antidepressive effects of diaryl-4,6-amino-3-pyridazine analogs of minaprine].
The reaction of 3-chloro pyridazines with various amines led to a series of minaprine analogues. Most of them exhibited significant antidepressant activity. The influence of the substituents attached to the pyridazine ring was discussed.
Coudert
P
P
Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Université de Clermont, Ferrand, France.
Rubat
C
C
Couquelet
J M
JM
Bastide
J
J
D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000633:toxicity; D002375:Catalepsy / Q000139:chemically induced; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D008297:Male; D051379:Mice; D009025:Morpholines / Q000037:antagonists & inhibitors; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000037:antagonists & inhibitors
D000928:Antidepressive Agents; D009025:Morpholines; D011724:Pyridazines; C006149:minaprine; D012110:Reserpine
Synthèse et étude de l'effet antidépresseur de diaryl-4,6 amino-3 pyridazines, analogues de la minaprine.