title: Sympathetic activity response to changes in the intake of sodium in chronic renal failure.
abstract: Sympathetic response to differences in sodium intake in patients with chronic renal failure was investigated. All patients were on haemodialysis, first for 3 weeks with conventional dialysate containing 148 mEq/l of sodium, then for another 3 weeks with the conventional dialysate containing 131 mEq/l of sodium. Increase in noradrenaline (NA), adrenaline (A), dopamine (DA) concentrations and dopamine-beta-hydroxylase (DBH) activity were found during the high-sodium haemodialysis. However, DBH activity in patients was significantly lower than in healthy individuals. A significant correlation was found between the level of plasma NA and systolic blood pressure. The present results suggest that a higher intake of sodium causes dysfunction of the sympathetic system.
authors.affiliation: Department of Nephrology, Medical School, Lublin, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Solski
authors.forename: A
authors.initials: A
authors.lastname: Ksiazek
mesh_terms: D000328:Adult; D001794:Blood Pressure; D004298:Dopamine / Q000097:blood; D004299:Dopamine beta-Hydroxylase / Q000097:blood; D004837:Epinephrine / Q000097:blood; D005921:Glomerulonephritis / Q000150:complications; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000378:metabolism*; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D006435:Renal Dialysis; D012964:Sodium / Q000494:pharmacology*; D013566:Sympathomimetics / Q000378:metabolism*
chemical_list: D013566:Sympathomimetics; D012964:Sodium; D004299:Dopamine beta-Hydroxylase; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine