title: Nifedipine prevents the pressor response to laryngoscopy and tracheal intubation in patients with coronary artery disease.
abstract: The efficacy of sublingual nifedipine, administered one minute before anaesthetic induction, in order to minimise the pressor response to laryngoscopy and tracheal intubation was studied in a group of 15 patients who underwent coronary artery bypass surgery. Another group of 15 similar patients served as control. Premedication consisted of oral diazepam 5-10 mg, intramuscular morphine 0.2 mg/kg and promethazine 0.4 mg/kg. Anaesthesia was induced with morphine 0.1-0.15 mg/kg and thiopentone 3-5 mg/kg. Laryngoscopy and tracheal intubation were facilitated with suxamethonium 1.5 mg/kg. A significant increase in blood pressure occurred during and after laryngoscopy and tracheal intubation in the control group. This increase was absent in the patients pretreated with nifedipine. The nifedipine group also maintained a lower rate-pressure-product than the control group during the period of study. It is concluded that nifedipine 10 mg is a useful pretreatment to prevent the pressor response to laryngoscopy and tracheal intubation in patients with coronary artery disease.
authors.affiliation: Department of Anaesthesiology and Cardiothoracic Surgery, All India Institute of Medical Sciences, New Delhi.
authors.forename: S C
authors.initials: SC
authors.lastname: Kale
authors.forename: R P
authors.initials: RP
authors.lastname: Mahajan
authors.forename: T S
authors.initials: TS
authors.lastname: Jayalakshami
authors.forename: V
authors.initials: V
authors.lastname: Raghavan
authors.forename: B
authors.initials: B
authors.lastname: Das
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D007828:Laryngoscopy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D011292:Premedication; D011897:Random Allocation
chemical_list: D009543:Nifedipine