A study of fucidin uptake in ischaemic tissues.
Twenty-five patients undergoing vascular surgery were given Fucidin 500 mg t.d.s. for the 3 days prior to surgery. Serum and fat levels obtained at the time of surgery show that the antibiotic is well absorbed and penetrates relatively ischaemic tissues. The levels obtained greatly exceed the MIC for Staphylococcus aureus.
Kendall
S W
SW
St. James's University Hospital, Leeds, UK.
Antrum
R M
RM
Ramsden
C H
CH
Kester
R C
RC
D000273:Adipose Tissue / Q000032:analysis; D005672:Fusidic Acid / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006119:Groin; D006801:Humans; D007511:Ischemia / Q000378:metabolism* / Q000601:surgery; D011292:Premedication; D014656:Vascular Surgical Procedures
D005672:Fusidic Acid