title: The dissolution rate of enamel in acid in developing rat incisors.
abstract: This study was undertaken to determine the changes in this dissolution rate at different developmental stages after different fluoride dietary regimes. Four groups of Wistar rats received water with 0, 25, 50 and 100 parts/10(6) fluoride respectively for 10 weeks. Six exposed windows of 2 mm2 were prepared on the enamel surface of the upper incisors, corresponding to six different developmental stages. The acid-dissolution rates were determined at each window by using 1.4 M sodium acetate-hydrochloric acid buffer (pH 2.3). The rate of enamel dissolution was highest in the matrix-formation stage and dropped sharply in a step-wise fashion towards the stages of secondary mineralization and iron deposition. The dissolution rate in the maturation stage decreased significantly with increasing intake of fluoride. However, in the pigmented enamel, the opposite occurred. The iron pigmentation or the porosity in this region of fluorosed enamel might be responsible for the change in the dissolution rate of the pigmented enamel.
authors.affiliation: Department of Preventive Dentistry and Dental Public Health, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Nakagaki
authors.forename: Y
authors.initials: Y
authors.lastname: Sakakibara
authors.forename: J A
authors.initials: JA
authors.lastname: Weatherell
authors.forename: C
authors.initials: C
authors.lastname: Robinson
mesh_terms: D000818:Animals; D003747:Dental Enamel Solubility / Q000187:drug effects*; D005459:Fluorides / Q000008:administration & dosage* / Q000032:analysis / Q000494:pharmacology; D006851:Hydrochloric Acid / Q000494:pharmacology*; D007180:Incisor / Q000032:analysis / Q000254:growth & development; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014078:Tooth Eruption
chemical_list: D005459:Fluorides; D006851:Hydrochloric Acid