Levels of metallic mercury and mercuric ion in the venous and arterial bloods of normal and acatalasemic mice following exposure to mercury vapor.
Levels of metallic mercury and mercuric ion in the arterial and venous bloods of normal and acatalasemic mice exposed to metallic mercury vapor in vitro and in vivo were investigated. Mercury uptake in venous blood from air saturated with mercury vapor with or without hydrogen peroxide in vitro was determined. Level of mercuric ion in venous blood of normal mice was significantly higher than that of acatalasemic mice. By contrast, metallic mercury in venous blood of acatalasemic mice was elevated relative to level in normal mice. Metallic mercury level in red blood cells and plasma was also significantly higher in acatalasemic mice. The ratio of metallic mercury to total mercury (Hg degrees + Hg2+) in the arterial and venous bloods of acatalasemic mice exposed to metallic mercury vapor was increased relative to normal mice. This ratio in red blood cells and plasma in the venous bloods of acatalasemic mice in vivo was also significantly higher than those of normal mice. The significance of metallic mercury in plasma for distribution of mercury in organs is discussed.
Aikoh
H
H
Department of Public Health, Okayama University Medical School, Japan.
Ogata
M
M
D020642:Acatalasia; D000818:Animals; D001158:Arteries; D002374:Catalase / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D066298:In Vitro Techniques; D008627:Mercuric Chloride / Q000493:pharmacokinetics; D008628:Mercury / Q000097:blood / Q000493:pharmacokinetics*; D008661:Metabolism, Inborn Errors / Q000097:blood / Q000201:enzymology*; D051379:Mice; D008809:Mice, Inbred C3H; D012016:Reference Values; D014680:Veins
D008627:Mercuric Chloride; D002374:Catalase; D008628:Mercury