title: Preparation of microcapsules from complex coacervation of Gantrez-gelatin. III. Bioavailability of nitrofurantoin microcapsules.
abstract: The bioavailability of marketed nitrofurantoin capsules was compared to capsules filled with Gantrez-gelatin nitrofurantoin microcapsules of a core:coat ratio of 1:2. The collective results obtained from the analysis of urine samples of five volunteers indicated that nitrofurantoin microcapsules provided a prolonged release compared with that of the control formulation. Analysis of variance showed statistically significant differences between the control formulation and the capsule filled with the microcapsule. Non-significant intersubject variation was noticed.
authors.affiliation: Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Egypt.
authors.forename: S A
authors.initials: SA
authors.lastname: Mortada
authors.forename: M A
authors.initials: MA
authors.lastname: el Egaky
authors.forename: A M
authors.initials: AM
authors.lastname: Motawi
authors.forename: K A
authors.initials: KA
authors.lastname: el Khodery
mesh_terms: D000328:Adult; D001682:Biological Availability; D002214:Capsules; D003692:Delayed-Action Preparations; D006801:Humans; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D009582:Nitrofurantoin