The vascular action of aqueous extracts of Foeniculum vulgare leaves.
The vascular effects of aqueous extracts of Foeniculum vulgare leaves were tested using pentobarbital-anaesthetised rats. An intravenous administration of the lyophilized boiled water extract of leaves produced a significant dose-related reduction in arterial blood pressure, without affecting the heart rate or respiratory rate. In contrast the non-boiled aqueous extract showed very little hypotensive activity. The hypotensive effect of the boiling water extract appeared not to be mediated via adrenergic, muscarinic, ganglionic or serotonergic receptors; however, histamine antagonists inhibited the hypotensive effect in a dose-related manner.
Abdul-Ghani
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AS
Biology and Biochemistry Department, Faculty of Science, Birzeit University, Occupied West Bank (via Israel).
Amin
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R
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002319:Cardiovascular System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006633:Histamine Antagonists / Q000494:pharmacology; D006358:Hot Temperature; D007557:Israel; D008297:Male; D010936:Plant Extracts / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects; D014867:Water
D000959:Antihypertensive Agents; D006633:Histamine Antagonists; D010936:Plant Extracts; D014867:Water