title: Neonatal screening for congenital adrenal hyperplasia using 17-hydroxyprogesterone assay in filter paper blood spots.
abstract: Screening of infants for congenital adrenal hyperplasia (CAH) using filter paper blood samples collected on the 5th day of life was performed with a radioimmunoassay for 17-hydroxyprogesterone without extraction with organic solvents. A total of 153,000 newborns were screened and 12 cases of CAH were detected (1:12,800). With recall levels related to gestational age, the recall rate could be lowered to 0.05%.
authors.affiliation: Department of Bacteriology, National Bacteriological Laboratory, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Larsson
authors.forename: L
authors.initials: L
authors.lastname: Hagenfeldt
authors.forename: U
authors.initials: U
authors.lastname: von Döbeln
authors.forename: T
authors.initials: T
authors.lastname: Curstedt
authors.forename: J
authors.initials: J
authors.lastname: Gustafsson
authors.forename: E
authors.initials: E
authors.lastname: Svensson
mesh_terms: D019326:17-alpha-Hydroxyprogesterone; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D006908:Hydroxyprogesterones / Q000097:blood*; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D008403:Mass Screening; D010209:Paper; D011863:Radioimmunoassay; D012016:Reference Values
chemical_list: D015415:Biomarkers; D006908:Hydroxyprogesterones; D019326:17-alpha-Hydroxyprogesterone