B-lymphocytic hairy cells contain no HTLV-II DNA sequences.
HTLV-II has been found in some cases of the rare T-cell form of hairy-cell leukemia (HCL) and in a leukopenic chronic T-cell leukemia mimicking HCL. We asked whether the virus is implicated in the more frequent B-cell form of HCL. DNA extracted from the mononuclear cells derived from spleen (eight cases) or peripheral blood (eight cases) of 16 patients with the B-cell form of HCL was probed. No viral sequences were detected at levels of sensitivity as low as one viral genome in five cells. Therefore HTLV-II may not be involved in the B-cell form of HCL.
Lion
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T
Joint Section of Hematology/Oncology, University of Chicago Medical Center.
Razvi
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N
Golomb
H M
HM
Brownstein
R H
RH
D001402:B-Lymphocytes / Q000032:analysis*; D001483:Base Sequence; D015139:Blotting, Southern; D004279:DNA, Viral / Q000302:isolation & purification*; D015367:Human T-lymphotropic virus 2 / Q000235:genetics*; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000235:genetics* / Q000473:pathology
D004279:DNA, Viral