title: Synthesis and preliminary pharmacological studies on dihydropyrido-1,3,4-triazepinone derivatives.
abstract: New 4,5-dihydropyrido-[2,3-e]-1,3,4-triazepin-5-one derivatives (2-9) were synthesized. The preliminary pharmacological tests revealed antinociceptive action of compounds 4-7 and 9 and antianxiety action of compound 4.
authors.affiliation: Department of Technology of Drugs, Medical Academy, Wroclaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Nawojski
authors.forename: H
authors.initials: H
authors.lastname: Liszkiewicz
authors.forename: W
authors.initials: W
authors.lastname: Nawrocka
authors.forename: M
authors.initials: M
authors.lastname: Wilimowski
authors.forename: J
authors.initials: J
authors.lastname: Barczyńska
authors.forename: L
authors.initials: L
authors.lastname: Kedzierska
authors.forename: W
authors.initials: W
authors.lastname: Wojewódzki
authors.forename: M
authors.initials: M
authors.lastname: Rutkowska
authors.forename: E
authors.initials: E
authors.lastname: Duś
authors.forename: A
authors.initials: A
authors.lastname: Szelag
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001058:Apomorphine / Q000494:pharmacology; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D012110:Reserpine / Q000037:antagonists & inhibitors; D012702:Serotonin Antagonists / Q000138:chemical synthesis
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D001381:Azepines; D004095:Dihydropyridines; D012702:Serotonin Antagonists; D012110:Reserpine; D001058:Apomorphine