title: Effect of sulfamethoxazole and trimethoprim on neurologic dysfunction in a patient with Joseph's disease.
abstract: Joseph's disease, an autosomal dominant, degenerative neurologic disease found in the Portuguese, is clinically manifested by extrapyramidal, pyramidal, and cerebellar dysfunction. A patient with the type II form of the disease reported improvement in gait and lessened spasticity while taking sulfamethoxazole and trimethoprim (Bactrim) for a noninfectious dysuria syndrome. A double-blind, placebo-controlled trial of Bactrim utilizing a subjective performance scale, physical examination, and six timed tests was performed in this patient. Results revealed lessened spasticity, improvement in walker-assisted gait, and correlative subjective responses. These results suggest an antispasticity effect of Bactrim or one of its components in this patient.
authors.affiliation: Department of Medicine, St. Luke's Hospital, New Bedford, Mass.
authors.forename: K A
authors.initials: KA
authors.lastname: Mello
authors.forename: B P
authors.initials: BP
authors.lastname: Abbott
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004338:Drug Combinations / Q000627:therapeutic use; D006801:Humans; D008124:Locomotion; D008297:Male; D009048:Motor Skills; D009128:Muscle Spasticity / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D009460:Neurologic Examination; D013132:Spinocerebellar Degenerations / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
chemical_list: D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole