[Endothelial relaxation factor as a local modulator of arterial function. The possibility of stabilization].
Endothelium-derived relaxing factor (EDRF) exerted no inhibitory effect on papillary muscles or the rat portal vein. Externally applied acetylcholine did not reach aorta endothelium to stimulate the EDRF release in rabbits, nor bradykinin in the pig coronary artery segments. Acetylcholine penetrated, however, canine femoral artery wall and stimulated the release of EDRF. Stabilizing of the EDRF released from perfused rabbit thoracic aorta, seems to be possible.
Vedernikov
Iu P
IuP
Gräzer
T
T
Osis
Iu G
IuG
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000187:drug effects*; D001688:Biological Products / Q000378:metabolism / Q000494:pharmacology*; D001920:Bradykinin / Q000494:pharmacology; D004285:Dogs; D004730:Endothelium, Vascular / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009569:Nitric Oxide; D010210:Papillary Muscles / Q000187:drug effects; D010477:Perfusion / Q000295:instrumentation; D011817:Rabbits; D013552:Swine; D014665:Vasodilator Agents / Q000378:metabolism / Q000494:pharmacology*
D001688:Biological Products; D014665:Vasodilator Agents; D009569:Nitric Oxide; D000109:Acetylcholine; D001920:Bradykinin
Endotelial'nyĭ faktor rasslableniia kak lokal'nyĭ moduliator funktsii arteriĭ. Vozmozhnost' stabilizatsii.