Cytogenetic analysis of 570 first trimester chorionic villi samplings: technique and results.
In this report we present our experience based on 570 chorionic villi samplings performed by the transcervical method at 8 to 12 weeks gestation. Cytogenetic results were obtained for 551 samples, hence a failure rate of 3.33%. The previously described technique was modified by prolonging the incubation period to 48 hours. The total number of abnormalities was 26, which represents 4.71% of our sample. Of 24 chromosomal abnormalities, 21 were unbalanced and 3 were balanced of parental origin. Five discordant cases are thoroughly discussed.
Jotterand-Bellomo
M
M
Division autonome de génétique médicale, Centre Hospitalier Universitaire Vaudois, Lausanne, Chuv, Switzerland.
Pescia
G
G
Nguyen The
H
H
Gaide
A C
AC
Thonney
F
F
Marguerat
P
P
Pacaud
F
F
Munier
F
F
D002824:Chorionic Villi / Q000648:ultrastructure*; D002869:Chromosome Aberrations / Q000175:diagnosis*; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D008722:Methods; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis; D012729:Sex Chromosome Aberrations / Q000175:diagnosis