[Effect of sialadenectomy on hepatic carcinogenesis in rats induced by N-nitrosodiethylamine].
It is established that sialadenectomy leads to inhibition of hepatocarcinogenesis induced in adult rats by diethylnitrosamine, which is confirmed by a decrease in the incidence of tumours, their delayed growth and an increase of longevity. But sialadenectomy 2 weeks after the beginning of carcinogen treatment has no effect on the hepatocarcinogenesis. A significant molecular heterogeneity of the epidermal growth factor-competing activity is observed in acid-ethanol extracts of the liver tumour of the sialadenectomized rats.
Osipova
L A
LA
Nemliĭ
N I
NI
Alekseeva
T A
TA
Bykorez
A I
AI
D000818:Animals; D004052:Diethylnitrosamine / Q000633:toxicity*; D004815:Epidermal Growth Factor / Q000032:analysis / Q000172:deficiency; D008099:Liver / Q000032:analysis; D008114:Liver Neoplasms, Experimental / Q000032:analysis / Q000139:chemically induced*; D008297:Male; D051381:Rats; D012469:Salivary Glands / Q000032:analysis / Q000502:physiology* / Q000601:surgery; D013997:Time Factors
D004052:Diethylnitrosamine; D004815:Epidermal Growth Factor
Vliianie sialadenéktomii na gepatokantserogenez, indutsirovannyĭ u krys N-nitrozodiétilaminom.