[HLA and narcolepsy. Apropos of 28 cases including 2 negative HLA-DR2].
Association between narcolepsy and HLA-DR2 antigen is the strongest so far described between an HLA antigen and a disease. Among 28 narcoleptic patients, we found two HLA-DR2 negative cases: a caucasoid woman also suffering from dystrophia myotonica and a negroid. All of our patients were HLA-DQW1 positive. An hypothetical narcolepsy susceptibility gene could be located in the HLA region, closer to the DQ than to the DR gene. It could be a pathologic allele of a sleep controlling gene in linkage disequilibrium with DQW1. Presence of DQW1 is a quasi-requisite for the expression of narcolepsy. It is not sufficient as it is observed in 70 p. 100 of controls.
Confavreux
C
C
Service de Neurologie, Hôpital Neurologique de Lyon.
Gebuhrer
L
L
Betuel
H
H
Freidel
C
C
Bastuji
H
H
Jouvet
M
M
Aimard
G
G
Devic
M
M
D000293:Adolescent; D000328:Adult; D002648:Child; D004247:DNA / Q000235:genetics; D005260:Female; D006681:HLA-D Antigens / Q000032:analysis*; D006683:HLA-DQ Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis* / Q000235:genetics; D015802:HLA-DR2 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D011110:Polymorphism, Genetic
D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; C051568:HLA-DQ1 antigen; D006684:HLA-DR Antigens; D015802:HLA-DR2 Antigen; D004247:DNA
HLA et narcolepsie. A propos de 28 cas dont deux HLA-DR2 négatifs.