Intravitreal toxicity of cotrimoxazole.
We investigated the intravitreal toxicity of cotrimoxazole (trimethoprim 80 mg and sulfamethoxazole 400 mg/5 ml of injection fluid) in albino rabbits. Eyes injected intravitreally with 1600 micrograms/0.1 cc (reported in trimethoprim concentration) exhibited no histologic or abnormal electroretinographic responses after 14 days. A vitrectomy infusion solution containing 32 micrograms/ml (reported in trimethoprim concentration) produced no toxicity, as demonstrated either by electroretinography or histology. Cotrimoxazole appears to be well-tolerated in rabbit eyes when administered by both intravitreal injection and vitrectomy infusion solution.
Fiscella
R
R
Department of Ophthalmology, Eye and Ear Infirmary, University of Illinois College of Medicine, Chicago.
Peyman
G A
GA
Kimura
A
A
Small
G
G
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000633:toxicity*; D004338:Drug Combinations / Q000008:administration & dosage / Q000633:toxicity; D004596:Electroretinography; D005123:Eye / Q000187:drug effects*; D007267:Injections; D011817:Rabbits; D012160:Retina / Q000187:drug effects; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000633:toxicity*; D013997:Time Factors; D014295:Trimethoprim / Q000008:administration & dosage / Q000633:toxicity*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014821:Vitrectomy; D014822:Vitreous Body / Q000187:drug effects
D000890:Anti-Infective Agents; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole