Changes of DNA synthesis in brain cortical cells after transplantation of embryonic nervous tissue into the brain of rats after hypoxia.
Autoradiographic and biochemical studies with 3H-thymidine have shown that after transplantation of embryonic nervous tissue of rats into the brain of adult rats, intact and subjected to acute hypoxic hypoxia causing mass dystrophy of neurons in the brain cortex of recipients, there occurs stimulation of DNA synthesis in non-nerve cells: glial cells, macrophages and endothelial cells. Stimulation is much more pronounced in the operated hemisphere than in the non-operated one and in intact rats than in hypoxia-subjected ones. On the whole, DNA synthesis was not observed in brain nerve cells except individual neurons located near the wound canal and the transplant.
Polezhaev
L V
LV
N.I. Vavilov Institute of General Genetics, USSR Academy of Sciences, Moscow.
Alexandrova
M A
MA
Vitvitsky
V N
VN
Cherkasova
L V
LV
Girman
S V
SV
D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology / Q000637:transplantation*; D004261:DNA Replication; D004622:Embryo, Mammalian; D005260:Female; D002534:Hypoxia, Brain / Q000473:pathology*; D009410:Nerve Degeneration; D009416:Nerve Regeneration; D009473:Neuronal Plasticity; D009474:Neurons / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains