[Testosterone stimulation of the growth of a human osteogenic sarcoma strain transplanted into athymic rats].
Intraperitoneal testosterone administration stimulated the growth of subcutaneously transplanted cell line of human osteogenic sarcoma in nude rats but did not provoke tumour metastasizing to other organs and tissues. The specific connection of androgens with receptor proteins in the cytosol fraction was not found in the studied osteogenic sarcomas, whereas cytoplasmic estrogen receptors were revealed in all tumours. It is supposed that the mechanism of the stimulating effect of androgens on the tumour growth is mediated through other biologic systems being not related to androgen receptors.
Bassalyk
L S
LS
Kushlinskiĭ
N E
NE
Revazova
E S
ES
Degtiar'
V G
VG
D000818:Animals; D002460:Cell Line; D003600:Cytosol / Q000032:analysis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D009368:Neoplasm Transplantation; D012516:Osteosarcoma / Q000032:analysis / Q000503:physiopathology*; D011869:Radioligand Assay; D051381:Rats; D011923:Rats, Nude; D011944:Receptors, Androgen / Q000032:analysis / Q000187:drug effects; D011960:Receptors, Estrogen / Q000032:analysis / Q000187:drug effects; D013268:Stimulation, Chemical; D013739:Testosterone / Q000494:pharmacology*
D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D013739:Testosterone
Stimuliatsiia testosteronom rosta shtamma osteogennoĭ sarkomy cheloveka, transplantirovannogo bestimusnym krysam.