IL-2-dependent proliferation of thymic accessory cells.
Phagocytic cells of the thymic reticulum are Ia-positive accessory cells continuously produced in long term thymic stroma cultures. We show in the present paper that phagocytic cells of the thymic reticulum have R for IL-2. They share this property with splenic accessory cells produced in vitro by the same technique but have the unique property of proliferating in the presence of rIL-2. This proliferation is not enhanced by Con-A, is not linked to a lymphoid contaminant, and is specifically inhibited by an anti-IL-2R mAb.
Rocha
B
B
Institut National de la Santé et de la Recherche Médicale U 25, Centre National de la Recherche Scientifique UA 122 Hôpital Necker, Paris, France.
Lehuen
A
A
Papiernik
M
M
D000818:Animals; D000938:Antigen-Presenting Cells / Q000166:cytology / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D007376:Interleukin-2 / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008819:Mice, Nude; D010586:Phagocytes / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D011994:Recombinant Proteins / Q000494:pharmacology; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology*
D007376:Interleukin-2; D011994:Recombinant Proteins