Twelve loci form a continuous linkage map for human chromosome 18.
We have constructed a primary genetic map of human chromosome 18 consisting of 11 DNA markers and one serological marker (JK). Two of these loci define highly polymorphic VNTR systems. The markers define a continuous genetic linkage map of 97 cM in males and 205 cM in females; female genetic distances in a panel of 59 three-generation families were consistently about twice those observed in males. The high odds in support of the linear order of the markers on this recombination map, and the extent of coverage of chromosome 18, indicate that this map will permit efficient linkage studies of human genetic diseases that may be segregating on chromosome 18 and will provide anchor points for development of high-resolution maps for this chromosome.
O'Connell
P
P
Howard Hughes Medical Institute, University of Utah Health Sciences Center, Salt Lake City 84132.
Lathrop
G M
GM
Leppert
M
M
Nakamura
Y
Y
Müller
U
U
Lalouel
J M
JM
White
R
R
D000483:Alleles; D002874:Chromosome Mapping; D002887:Chromosomes, Human, Pair 18; D005260:Female; D008040:Genetic Linkage; D006579:Heterozygote; D006801:Humans; D008297:Male; D011995:Recombination, Genetic; D015183:Restriction Mapping