title: Effects of synthetic kassinin on splanchnic circulation and exocrine pancreas in dogs.
abstract: Effects of intravenously administered synthetic kassinin on splanchnic circulation and exocrine pancreatic secretion were examined in six anesthetized dogs. Kassinin caused dose-related increases in the blood flow in superior mesenteric artery and portal vein, and produced an initial increase followed by a decrease in pancreatic blood flow, but did not affect the exocrine pancreatic secretion. This study demonstrates that kassinin affects splanchnic blood flow in dogs, and suggests that kassinin or a kassinin-like substance functions as a neuropeptide controlling the splanchnic circulation in mammalian species.
authors.affiliation: First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Doi
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Kogire
authors.forename: S
authors.initials: S
authors.lastname: Sumi
authors.forename: K
authors.initials: K
authors.lastname: Takaori
authors.forename: M
authors.initials: M
authors.lastname: Yun
authors.forename: H
authors.initials: H
authors.lastname: Yajima
authors.forename: T
authors.initials: T
authors.lastname: Tobe
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D015286:Kassinin / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D010189:Pancreatic Juice / Q000187:drug effects / Q000378:metabolism*; D012016:Reference Values; D012039:Regional Blood Flow / Q000187:drug effects; D012633:Secretin / Q000494:pharmacology; D013152:Splanchnic Circulation / Q000187:drug effects*
chemical_list: D012633:Secretin; D015286:Kassinin