Effect of cyclosporine on the antigen-presenting function of human and murine accessory cells.
Recent reports have challenged the belief that accessory cells are resistant to cyclosporine. Such a tenet was based on the observation that several functions of accessory cells, such as IL-1 production and phagocytosis, are resistant to the drug. On the other hand, when a less primitive, more refined function of accessory cells was examined--i.e., the capacity to take up, process, and present antigen in an MHC-restricted fashion to antigen-specific T lymphocytes, CsA proved to be an effective inhibitor. In contrast to this finding, when antigen was provided in the form of an immune complex prepared with a monoclonal antibody, uptake of antigen--likely mediated by the Fc receptors--and subsequent processing and presentation were not affected by CsA. These results suggest that, depending on whether the antigen is taken up by constitutive or by receptor-mediated endocytosis, accessory cells can be functionally defined as resistant or sensitive to CsA.
Manca
F
F
Department of Immunology, University of Genoa, Italy.
Fenoglio
D
D
Kunkl
A
A
Caltabellotta
M
M
Celada
F
F
D000818:Animals; D000936:Antigen-Antibody Complex; D000938:Antigen-Presenting Cells / Q000187:drug effects* / Q000276:immunology; D000941:Antigens; D003524:Cyclosporins / Q000494:pharmacology*; D004705:Endocytosis / Q000187:drug effects; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D011961:Receptors, Fc / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology
D000936:Antigen-Antibody Complex; D000941:Antigens; D003524:Cyclosporins; D011961:Receptors, Fc