[Immunosuppressive treatment after organ transplantation].
The success of organ transplantation depends mostly on immunosuppressive treatments which depress the host vs allograft immune response. The drugs mostly used in the past, Azathioprine and Corticosteroids, act in a non specific way. Heterologous antilymphocyte sera are progressively replaced by monoclonal antibodies specific of lymphocyte subpopulations, such as OKT3 which is a highly potent immunosuppressive agent. Cyclosporin, a new original immunosuppressive agent which acts specifically on T lymphocytes, has considerably improved organ graft survival rates especially for heart and liver. Moreover, it allows reduction of the doses or corticosteroids given after transplantation an thus limits their side-effects, especially on statural growth. However, cyclosporin nephrotoxicity represents the major problem, at least in the long-term.
Niaudet
P
P
Service de Néphrologie Pédiatrique, Hôpital des Enfants-Malades, Paris.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D003524:Cyclosporins / Q000627:therapeutic use; D006789:Host vs Graft Reaction / Q000187:drug effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D014180:Transplantation
D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D000961:Antilymphocyte Serum; D003524:Cyclosporins; D007166:Immunosuppressive Agents; D001379:Azathioprine
Traitements immunosuppresseurs après transplantation d'organe.