The hypoglycemic effects of tryptamine in mice: mediation by 5-HT receptors.
The effects of tryptamine on blood glucose levels were studied. Tryptamine induced significant hypoglycemia in mice. The hypoglycemia elicited by tryptamine was strongly antagonized by methysergide, an antagonist of both 5-HT1 and 5-HT2 receptors. A 5-HT2 receptor antagonist, ketanserin, partially inhibited the tryptamine-induced hypoglycemia. These results suggest that tryptamine-induced hypoglycemia is mediated by 5-HT1 and 5-HT2 receptors.
Yamada
J
J
Department of Pharmacology, Kobe Women's College of Pharmacy, Japan.
Sugimoto
Y
Y
Kimura
I
I
Takeuchi
N
N
Horisaka
K
K
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced*; D008784:Methysergide / Q000494:pharmacology; D051379:Mice; D011985:Receptors, Serotonin / Q000502:physiology*; D014363:Tryptamines / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D001786:Blood Glucose; D011985:Receptors, Serotonin; D014363:Tryptamines; C030820:tryptamine; D008784:Methysergide