Effects of ethanol withdrawal on ethanol-reinforced responding in rhesus monkeys.
Rhesus monkeys self-administered ethanol intravenously during daily, 3-h sessions. When ethanol-reinforced responding was stable and ethanol intake was in the range of 2.6-3.6 g/kg/3 h, physiological dependence to ethanol was induced by daily passive infusions of additional ethanol. In less than 1 week, mild to moderate withdrawal signs were observed prior to daily sessions. Ethanol intake was suppressed in the presence of these withdrawal signs and returned to normal only after withdrawal signs had subsided.
Winger
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Department of Pharmacology, University of Michigan, Ann Arbor 48109.
D000818:Animals; D001522:Behavior, Animal; D000431:Ethanol / Q000008:administration & dosage*; D008253:Macaca mulatta; D008297:Male; D012646:Self Administration; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D019966:Substance-Related Disorders / Q000503:physiopathology*
D000431:Ethanol