Radiolabeled porphyrin vs gallium-67 citrate for the detection of human melanoma in athymic mice.
We performed the biodistribution and imaging studies of 111In and 67Ga labeled tetra(4-N-methylpyridyl)porphine, (T4NMPYP), and compared it to that of 67Ga-citrate in athymic mice bearing a human melanoma xenograft. The biodistribution results of both 111In and 67Ga labeled T4NMPYP (3, 6, 24 and 48 h) were similar but differed from that of 67Ga-citrate (48 h). The optimum tumor uptake of both radiolabeled porphyrins was at 6 h post-injection and was lower than the tumor uptake of 67Ga-citrate at 48 h post-injection. Kidney was the only organ showing higher uptake of radiolabeled porphyrin compared to that of 67Ga-citrate. The imaging studies performed with 111In-T4NMPYP and 67Ga-citrate correspond to the biodistribution results. Osteomyelitis present in one mouse showed good localization of 111In-T4NMPYP.
Maric
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Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06510.
Chan
S M
SM
Hoffer
P B
PB
Duray
P
P
D000818:Animals; D002951:Citrates; D019343:Citric Acid; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D007205:Indium Radioisotopes; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011166:Porphyrins / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D014018:Tissue Distribution; D014183:Transplantation, Heterologous
D002951:Citrates; D005710:Gallium Radioisotopes; D007205:Indium Radioisotopes; D011166:Porphyrins; D019343:Citric Acid; C021096:tetra(4-N-methylpyridyl)porphine