Direct high-performance liquid chromatographic resolution of dihydropyridine enantiomers.
A direct high-performance liquid chromatographic enantioseparation on a chiral stationary phase using a protein as chiral selector was achieved for some dihydropyridines with different structural groups (amine, amide, acid and hydroxyl groups). The protein involved was alpha 1-acid glycoprotein and the work was mainly carried out with an EnantioPac column. An improved version of this chiral column (Chiral-AGP) was compared with the previous one and gave interesting results.
Delee
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E
Recherche Syntex France, Leuville-sur-Orge, Montlhéry.
Jullien
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I
Le Garrec
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L
D002851:Chromatography, High Pressure Liquid; D004095:Dihydropyridines / Q000302:isolation & purification*; D006863:Hydrogen-Ion Concentration; D009961:Orosomucoid / Q000032:analysis; D013237:Stereoisomerism; D013696:Temperature
D004095:Dihydropyridines; D009961:Orosomucoid