EGF binding is quantitatively related to growth in node-positive breast cancer.
Number of mitoses and EGF binding were determined in parallel in biopsies of 27 lymph-node positive and of 23 lymph-node negative breast cancer patients. For node-positive patients the parameters for cell growth and EGF binding were quantitatively correlated by the equation y = P3 + P1(1- exp(- P2x]. For node-negative cases neither the non-linear model nor the linear approximation described the data unambiguously. The results strongly suggest that in node-positive patients, growth of breast cancer is related to an EGF-dependent acceleration of cell division.
Spitzer
E
E
Central Institute of Molecular Biology, Academy of Sciences of the German Democratic Republic, Berlin-Buch.
Koepke
K
K
Kunde
D
D
Grosse
R
R
D000328:Adult; D000368:Aged; D001665:Binding Sites; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D004815:Epidermal Growth Factor / Q000378:metabolism*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged
D004815:Epidermal Growth Factor