title: An algorithm for simultaneous comparison of several sequences.
abstract: An algorithm was developed to compare simultaneously several DNA, RNA or protein sequences. With the algorithm, conserved regions of one sequence are located by doing pairwise comparisons with other sequences, which is advantageous in planning site-directed mutagenesis studies. The observation matrices filled with scores of comparisons are superimposed and added together and those points having values greater than or equal to stringency are accepted. The predicted secondary structural features can also be compared.
authors.affiliation: Department of Biochemistry, University of Turku, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Vihinen
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D001407:Bacillus / Q000201:enzymology / Q000235:genetics; D001483:Base Sequence; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid; D012984:Software; D013045:Species Specificity; D000516:alpha-Amylases / Q000235:genetics
chemical_list: D000516:alpha-Amylases