[The value of hypertension and metabolic factors on the development of coronary heart disease in type II diabetic patients].
In 1,126 newly manifested type II diabetics of the diabetes intervention study (628 male, 498 female) between 30 and 55 years of age by a univariate and multivariate analysis the influence of atherogenic risk factors on the development of the coronary heart disease was tested. The diagnosis coronary heart disease is based on the ECG at rest (Minnesota-code), in 796 test persons an exercise electrocardiogram was made. In a manifestation of diabetes males with coronary heart disease showed higher mean values for systolic and diastolic blood pressure, body mass index and serum triglycerides than the control group free of coronary heart disease. In females systolic and diastolic blood pressure, uric acid level and age were significantly increased. By means of multidimensional analysis of variance as to the major findings in the ECG at rest (Q/QS type) in males the diastolic blood pressure, in females the systolic blood pressure and the serum uric acid proved to be significant. Minor findings (above all disturbances of repolarisation) were in males significantly associated with the triglycerides and the diastolic blood pressure, in the females with the systolic blood pressure and the age. Test persons with a stage of coronary heart disease which is to be recognized only in the exercise ECG in the behaviour of the mean value of the atherogenic risk factors did not differ from the control group free of findings with the exception of the increased serum triglycerides in the females.
Schmechel
H
H
Medizinischen Klinik, Medizinischen Akademie Carl Gustav Carus Dresden.
Schulze
J
J
Hanefeld
M
M
Julius
U
U
Schwanebeck
U
U
Lippold
C
C
D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004562:Electrocardiography; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood*; D014527:Uric Acid / Q000097:blood
D001786:Blood Glucose; D014280:Triglycerides; D014527:Uric Acid; D002784:Cholesterol
Zur Wertigkeit von Hypertonie und metabolischen Einflussfaktoren auf die Entstehung der koronaren Herzkrankheit bei Typ-II-Diabetikern.