Innate anti-listerial resistance of mice differing in their susceptibility to listeriosis.
The work was designated to compare the influence of an active immunization on the expression of anti-listerial resistance of relatively resistant to listeriosis C57B1/6 mice as compared with more susceptible to the infection DBA/2 mice. Although, specific immunization of DBA/2 mice enhanced their anti-listerial resistance but immunized DBA/2 mice still eliminated Listeria rods less effectively than immunized C57B1/6 mice. It means that innate difference in anti-listerial resistance between C57B1/6 and DBA/2 mice was maintained after immunizing them with the same number of alive bacteria. Greater anti-listerial resistance of C57B1/6 versus DBA/2 mice is associated with an increased accumulation of inflammatory Ms and PMNs in their peritonea and an increased capacity of their PMNs to restrict Listeria growth.
Długońska
H
H
Department of Immunology, University of Lódź.
Chmiela
M
M
Kierońska
D
D
Rózałska
B
B
Rudnicka
W
W
D000818:Animals; D001770:Blood Bactericidal Activity; D001853:Bone Marrow / Q000473:pathology; D007110:Immunity, Active; D008088:Listeriosis / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology; D010529:Peritoneal Cavity / Q000473:pathology; D010587:Phagocytosis