Host reactions to Mycoplasma pneumoniae infections in guinea-pigs preimmunized systemically with the adhesin of this pathogen.
Guinea-pigs developed systemic and local humoral responses after intraperitoneal immunization with the isolated adhesin (168 kDa protein) of Mycoplasma pneumoniae cells. Hilar lymphocytes of these animals showed proliferation after in vitro stimulation with the 168 kDa protein or sonicated M. pneumoniae whole cell antigen. Animals preimmunized and subsequently infected with M. pneumoniae showed increased M. pneumoniae-specific IgG, IgA and adherence inhibiting antibody activities. Nevertheless these animals developed severe lung lesions of lympho-histiocyte infiltrations. Furthermore hilar lymph nodes were depleted of immunocompetent lymphocytes, suggesting a cell transfer of specific stimulable lymphocytes to the inflammation sites.
Jacobs
E
E
Institute for Medical Microbiology and Hygiene, University of Freiburg, West Germany.
Stuhlert
A
A
Drews
M
M
Pumpe
K
K
Schaefer
H E
HE
Kist
M
M
Bredt
W
W
D018829:Adhesins, Bacterial; D000818:Animals; D000917:Antibody Formation; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000276:immunology*; D006168:Guinea Pigs; D007111:Immunity, Cellular; D007114:Immunization; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D011019:Pneumonia, Mycoplasma / Q000276:immunology*
D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; C035471:adhesin, Mycoplasma pneumoniae