[Sorption of a macrophage factor inducing functional thymocyte transformation on cells of organs of various sources].
When the macrophages and thymocytes are jointly incubated, mononuclear phagocytes produce a humoral factor which induces the functional transformation of thymocytes promoting their differentiation into more mature cells. The factor was provisionally called FIT (factor of induction of thymocytes). The data are provided on adsorption of the factor under study on cells of different organ origin. Thymocytes adsorb the FIT in proportion with the cell concentration and time of interaction between the factor and thymocytes. The FIT was shown to be adsorbed only on the T-cells. It is suggested that the differential sorption of the FIT is due to the presence of the FIT receptors only on T-lymphocytes.
Golenishchev
V Iu
VIu
Anfalova
T V
TV
Galaktionov
V G
VG
D000327:Adsorption; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D006023:Glycoproteins / Q000494:pharmacology*; D006087:Graft vs Host Reaction / Q000187:drug effects; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008970:Molecular Weight; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology
D006023:Glycoproteins
Sorbtsiia makrofagal'nogo faktora, indutsiruiushchego funktsional'nuiu transformatsiiu timotsitov, na kletkakh razlichnogo organnogo proiskhozhdeniia.