Corticotropin-releasing factor: central nervous system effects on baroreflex control of heart rate.
The effects of intracerebroventricular injections of corticotropin-releasing factor on baroreflex control of heart rate were examined in conscious, unrestrained rats. Baroreflex control of heart rate was tested by generating stimulus-response curves relating arterial pressure to pulse interval over a wide range of arterial pressures. Administration of corticotropin-releasing factor produced dose-related alterations of pressure-dependent curve parameters, e.g., range, gain and pressure at midrange. These results suggest that corticotropin-releasing factor alters transmission in neural pathways that process baroreceptor information.
Fisher
L A
LA
Department of Pharmacology, University of Arizona Health Sciences Center, Tucson 85724.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects*; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D011311:Pressoreceptors / Q000187:drug effects*; D051381:Rats; D012018:Reflex / Q000187:drug effects
D003346:Corticotropin-Releasing Hormone