[Characteristics of the effect of glycine and gamma-aminobutyric acid on the spinal cord neurons in the lamprey].
Responses of isolated spinal cord neurons of lamprey on glycine and gamma-aminobutyric acid (GABA) were investigated by means of intracellular perfusion and concentration clamp techniques. Responses on both amino acids exhibited fast but not full desensitization. Preincubation of neurons in the solution of one mediator led to full disappearance of the response to other mediator. It is suggested that these amino acids act on the same channel-receptor complex.
Safronov
B V
BV
Baev
K V
KV
Batueva
I V
IV
Rusin
K I
KI
Suderevskaia
E I
EI
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005399:Fishes / Q000502:physiology*; D005998:Glycine / Q000494:pharmacology*; D007798:Lampreys / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D005680:gamma-Aminobutyric Acid; D005998:Glycine
Osobennosti vliianiia glitsina i gamma-aminomaslianoĭ kisloty na neĭrony spinnogo mozga minogi.