title: 99mTc-MDP uptake and histological changes during rat bone marrow regeneration.
abstract: An established experimental model of tibial bone regeneration in rats was used in order to try to provide further information on the binding site of 99mTc-MDP, which is still not clearly defined. Four groups of rats on which surgical tibial bone marrow evacuation was performed and two control groups (nonoperated animals and sham-operated animals) underwent bone scan during the different stages of marrow regeneration; they were killed immediately after, and histological examination carried out. The correlation between the scintigraphic and the histological findings suggests that 99mTc-MDP binds primarily to calcification sites in young bone trabecules.
authors.affiliation: Department of Medical Biophysics and Nuclear Medicine, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Chisin
authors.forename: D
authors.initials: D
authors.lastname: Gazit
authors.forename: M
authors.initials: M
authors.lastname: Ulmansky
authors.forename: A
authors.initials: A
authors.lastname: Laron
authors.forename: H
authors.initials: H
authors.lastname: Atlan
authors.forename: J
authors.initials: J
authors.lastname: Sela
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000502:physiology*; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D012038:Regeneration; D013669:Technetium Tc 99m Medronate / Q000378:metabolism / Q000493:pharmacokinetics*
chemical_list: D013669:Technetium Tc 99m Medronate