The effect of iodide depletion and supplementation in the Buffalo strain rat.
We have investigated the effect of excess iodide alone, following iodide depletion or in conjunction with a mild thyroid insult (trypan blue) in Buffalo strain rats, which are genetically susceptible to experimental autoimmune thyroiditis. In all three cases a high iodine diet led to enhanced thyroglobulin antibody production, usually accompanied by worsening of the severity of thyroiditis. Moreover, the administration of a normal iodine diet after iodide depletion resulted in thyroglobulin antibody formation. These results provide further support for a role for dietary iodine in modulating experimental autoimmune thyroiditis with implications for human thyroid autoimmunity.
Cohen
S B
SB
University of Cambridge, Department of Medicine, United Kingdom.
Weetman
A P
AP
D000818:Animals; D004032:Diet; D005260:Female; D007455:Iodine / Q000008:administration & dosage* / Q000172:deficiency / Q000493:pharmacokinetics; D008297:Male; D051381:Rats; D011915:Rats, Inbred BUF / Q000378:metabolism*; D011919:Rats, Inbred Strains / Q000378:metabolism*; D013961:Thyroid Gland / Q000187:drug effects; D013966:Thyroiditis / Q000139:chemically induced; D014343:Trypan Blue / Q000494:pharmacology
D007455:Iodine; D014343:Trypan Blue