The effect of verapamil on serotonergic mechanisms in the rat blood platelets.
Verapamil in vitro inhibits the uptake and enhances the release of the labeled serotonin from the rat blood platelets. It also inhibits the facilitating action of serotonin on the aggregation response of platelets stimulated by ADP. The obtained results indicate that verapamil significantly influences serotonergic mechanisms in the blood platelets, at least in the rat.
Pietraszek
M
M
Department of Pharmacodynamics, Medical Academy, Bialystok, Poland.
Chabielska
E
E
Malinowska
B
B
Buczko
W
W
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000097:blood* / Q000502:physiology; D014700:Verapamil / Q000494:pharmacology*
D012701:Serotonin; D014700:Verapamil; D007099:Imipramine