title: Nonsteroidal anti-inflammatory agents. Part 17: Stereomeric o-, m-tolyl- and anisyl-biphenylyl-hydroxypropionic acids.
abstract: As a part of wider research project on chiral anti-inflammatory arylacanoic acids, the 3-(o- and m-)-(methyl and methoxy)-phenyl-2-biphenylyl-3-hydroxypropionic acids 3a-d were synthesized and resolved in their optically active erythro and threo stereomers, which were submitted to the carrageenan induced rat paw edema test. With respect to the p-isomers, only the threo p-methoxy substitution enhances the anti-inflammatory activity. Some conclusions on structure-activity relationship are discussed.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia dell'Università die Bologna, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Varoli
authors.forename: A
authors.initials: A
authors.lastname: Guarnieri
authors.forename: S
authors.initials: S
authors.lastname: Burnelli
authors.forename: N
authors.initials: N
authors.lastname: Ghedini
authors.forename: G
authors.initials: G
authors.lastname: Scapini
authors.forename: S
authors.initials: S
authors.lastname: Ferri
authors.forename: E
authors.initials: E
authors.lastname: Cavicchini
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D004487:Edema / Q000188:drug therapy; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008968:Molecular Conformation; D011422:Propionates / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates