[Induction of thymocyte proliferation with B cell stimulatory factor-1].
Murine B cell stimulatory factor (BSF)-1 or interleukin 4 has been shown to regulate various aspects of B cell activation and differentiation. More recently it has been shown that this lymphokine is also involved in the regulation of T cell and mast cell proliferation. In this study we purified BSF-1 activity from supernatants of T cell hybridoma FS6-14. 13 and tested its activity on a variety of in vitro assays. It was found that the purified BSF-1 material has various activities previously ascribed to BSF-1, and interestingly enough it also induces strong proliferation of thymocytes in collaboration with phytohemagglutinin. These results strongly suggest that BSF-1 plays a regulatory role in thymocyte differentiation and further support the notion that lymphokines generally have a broad spectrum of activity.
Kawabata
I
I
Second Department of Pathology, Asahikawa Medical College.
Asida
T
T
Yakura
H
H
D000818:Animals; D002457:Cell Extracts / Q000494:pharmacology; D002478:Cells, Cultured; D005260:Female; D015847:Interleukin-4; D007378:Interleukins / Q000494:pharmacology*; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000187:drug effects*
D002457:Cell Extracts; D007378:Interleukins; D015847:Interleukin-4