1H-nmr analysis of herbimycins and dihydro-herbimycins.
Herbimycin A [1] and herbimycin C [3] and their dihydro-derivatives 5 and 6, respectively, have been obtained from the cell broth of Streptomyces hygroscopicus, and the assignment of their 1H-nmr has been completed. Strong cytotoxic activity of antibiotics 1, 3, 5, and 6 against the P-388 and KB lymphocytic leukemia test systems has been demonstrated.
Lin
L Z
LZ
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612.
Blaskó
G
G
Cordell
G A
GA
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D016227:Benzoquinones; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D047029:Lactams, Macrocyclic; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011809:Quinones / Q000302:isolation & purification* / Q000494:pharmacology; D017828:Rifabutin / Q000031:analogs & derivatives; D013302:Streptomyces / Q000032:analysis; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D016227:Benzoquinones; D047029:Lactams, Macrocyclic; D011809:Quinones; D017828:Rifabutin; C020754:herbimycin; C051062:herbimycin C