title: Hidradenitis suppurativa. Glucose tolerance, clinical, microbiologic, and immunologic features and HLA frequencies in 27 patients.
abstract: Glucose tolerance, lymphocyte populations, and HLA types were studied in 27 patients with untreated hidradenitis suppurativa; 18 of these patients had a negative history for acne vulgaris. Six patients (22%) had an increased incidence of impaired glucose tolerance. We failed to confirm a previous report of high incidence of flat glucose tolerance curves. The frequency of HLA-A and HLA-B antigen loci and the median values of peripheral blood T lymphocytes were similar to the control population. However, seven patients with moderate or severe clinical disease had a marked reduction in T lymphocytes and these patients had an increased frequency of the HLA antigens, A1 and B8. These results suggest that T lymphocytes may play a role in the pathogenesis of hidradenitis suppurativa and that HLA-A1 and HLA-B8 may predispose the patient to more severe disease, but further research is necessary to clarify this.
authors.affiliation: Department of Dermatology, Mater Misericordiae Hospital, Dublin, Ireland.
authors.forename: S
authors.initials: S
authors.lastname: O'Loughlin
authors.forename: R
authors.initials: R
authors.lastname: Woods
authors.forename: P N
authors.initials: PN
authors.lastname: Kirke
authors.forename: F
authors.initials: F
authors.lastname: Shanahan
authors.forename: A
authors.initials: A
authors.lastname: Byrne
authors.forename: M I
authors.initials: MI
authors.lastname: Drury
mesh_terms: D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes; D005260:Female; D005951:Glucose Tolerance Test; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007249:Inflammation / Q000209:etiology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013543:Sweat Gland Diseases / Q000209:etiology* / Q000235:genetics / Q000382:microbiology; D013601:T-Lymphocytes
chemical_list: D006680:HLA Antigens