[Modifying action of carbamoylation reaction on mutagenic and toxic effects of alkylating compounds and heavy metal salts].
Using mammalian somatic cells (CHO-AT3-2) we have demonstrated a synergistic effect of ethyl methane sulfonate and a carbamoylating agent, potassium cyanate. Potassium cyanate aggravated the toxic action of EMS and the induction of predominantly micro- and macroaberrational mutation, whereas the rate of point mutations of the base substitution type was not affected. No synergistic effect was observed when potassium cyanate was used in combination with heavy metal salts, regardless of the test employed.
Sal'nikova
L E
LE
Pashin
Iu V
IuV
D000477:Alkylating Agents / Q000633:toxicity*; D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D019256:Cadmium Chloride; D002460:Cell Line; D002840:Chromates / Q000633:toxicity*; D006224:Cricetinae; D003412:Cricetulus; D003485:Cyanates / Q000633:toxicity*; D004357:Drug Synergism; D005020:Ethyl Methanesulfonate / Q000633:toxicity; D009154:Mutation; D011192:Potassium Dichromate / Q000633:toxicity*
D000477:Alkylating Agents; D002840:Chromates; D003485:Cyanates; D002104:Cadmium; D005020:Ethyl Methanesulfonate; C024835:potassium cyanate; D019256:Cadmium Chloride; D011192:Potassium Dichromate
Izuchenie modifitsiruiushchego deĭstviia reaktsii karbamoilirovaniia na mutagennye i toksicheskie éffekty alkiliruiushchikh soedineniĭ i soleĭ tiazhelykh metallov.