title: [Experimental parkinsonian syndrome in rats induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine].
abstract: Systemic administration of high doses of MPTP caused transient bradykinesia, "freezing" episodes, head tremors, hunching of the back and peripheral autonomic effects. Neurological syndrome was clearly dose-dependent. It has been established that Parkinson's syndrome is caused by high-amplitude paroxysmal discharges in the nucleus caudatis. It is concluded that the nucleus caudatis plays the role of a pathological determinant structure in the development of Parkinson's syndrome induced by MPTP.
authors.forename: G N
authors.initials: GN
authors.lastname: Kryzhanovskiĭ
authors.forename: M A
authors.initials: MA
authors.lastname: Atadzhanov
authors.forename: V A
authors.initials: VA
authors.lastname: Zagorevskiĭ
authors.forename: L M
authors.initials: LM
authors.lastname: Sharkova
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D008297:Male; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D011725:Pyridines; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011725:Pyridines; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
vernacular_title: Eksperimental'nyĭ parkinsonicheskiĭ sindrom u krys, vyzvannyĭ 1-metil-4-fenil-1,2,3,6-tetragidropiridinom.