Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis.
Possible associations between HLA-DR4 and laboratory, radiographic, joint count, functional, and demographic measures of clinical status were analyzed in 154 white patients with rheumatoid arthritis. Overall, 65 percent of the patients were HLA-DR4 positive, similar to other series. HLA-DR4 was associated significantly with the presence of rheumatoid factor and more severe radiographic changes. HLA-DR4 was not associated with significant differences in demographic, joint count, or functional measures of clinical status. HLA-DR1 was not associated significantly with differences in the presence of rheumatoid factor, radiographic changes, or other measures of clinical status. Selective associations of HLA-DR4 with rheumatoid factor and radiographic scores were more marked in men than in women. Patients who were putatively homozygous for HLA-DR4 were all seropositive and had more severe radiographic changes than patients who were heterozygous for HLA-DR4.
Olsen
N J
NJ
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Callahan
L F
LF
Brooks
R H
RH
Nance
E P
EP
Kaye
J J
JJ
Stastny
P
P
Pincus
T
T
D000203:Activities of Daily Living; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006681:HLA-D Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis* / Q000235:genetics; D015804:HLA-DR4 Antigen; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012217:Rheumatoid Factor / Q000032:analysis*
D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; D012217:Rheumatoid Factor