title: In vitro induction of differentiation in HL-60 leukemic cell line by clerodendron fragrans.
abstract: The promyelocytic cell line HL-60 could be induced to differentiate into morphologically and functionally mature monocytoid cells (up to 20%) following exposure to the Chinese herb Clerodendron Fragrans (1 mg/ml). This effect was time dependent and appeared to work synergistically with interferon-r in this promotion of differentiation. Our study suggests that Clerodendron Fragrans has potential therapeutic value for the treatment of certain acute myelocytic leukemia putatively caused by a block in the myeloid differentiation process.
authors.affiliation: Department of Medicine, Veterans General Hospital, Taipei, Taiwan.
authors.forename: P M
authors.initials: PM
authors.lastname: Chen
authors.forename: L L
authors.initials: LL
authors.lastname: Yung
authors.forename: K I
authors.initials: KI
authors.lastname: Hsiao
authors.forename: C M
authors.initials: CM
authors.lastname: Chen
authors.forename: H M
authors.initials: HM
authors.lastname: Yeh
authors.forename: M H
authors.initials: MH
authors.lastname: Chuang
authors.forename: C H
authors.initials: CH
authors.lastname: Tzeng
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal