The use of low dose cyclosporin A in a case of recalcitrant erythrodermic psoriasis.
A 48-year-old Thai female, who had stage 2 carcinoma of the breast presented with recalcitrant erythrodermic psoriasis which was unresponsive to conventional therapies. She was prescribed 6 mg/kg.day cyclosporin A. The erythroderma responded rapidly and was completely cleared within 3 weeks. The dosage was reduced in a step-wise manner to 4 and then 2 mg/kg.day and was stopped after 2 months of treatment. Complete clearing of the skin lesion was observed without any side-effects except mild nausea. The patient was then referred to surgery for mastectomy and chemotherapy. There was no clinical relapse during more than 1 year of follow-up and at present she is continuing to do well.
Sutthipisal
N
N
Division of Dermatology, Bhumibol Adulyadej Hospital, Royal Thai Air Force, Bangkok, Thailand.
Sriwatsantsak
J
J
Sirimachan
S
S
Nitidandhabaprabhas
P
P
D000410:Alanine Transaminase / Q000097:blood; D001943:Breast Neoplasms / Q000150:complications; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011565:Psoriasis / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology
D003524:Cyclosporins; D000410:Alanine Transaminase