[Study on orally active cephalosporin pro-drug. Synthesis, oral absorption and antibacterial activity of (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 7-[D-O-(aminoacyl)mandelamido]-3-[[(5-methyl-1,3,4-thiadiazol -2-yl)-thio]methyl]-3-cephem-4-carboxylates].
Nishizawa
S
S
Yoshimi
A
A
Muro
H
H
Kasai
M
M
Hatano
S
S
Hashizume
H
H
Yamada
T
T
Hashimoto
E
E
Nishimura
K
K
Kakeya
N
N
D000818:Animals; D002437:Cefazolin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000627:therapeutic use; D002511:Cephalosporins; D007408:Intestinal Absorption; D051379:Mice; D011355:Prodrugs; D012141:Respiratory Tract Infections / Q000188:drug therapy; D013329:Structure-Activity Relationship; D014552:Urinary Tract Infections / Q000188:drug therapy
D002511:Cephalosporins; D011355:Prodrugs; C022605:cefcanel; C045380:cefcanel daloxate; D002437:Cefazolin