Pharmacokinetics of gentamicin in laboratory rabbits.
The pharmacokinetics of gentamicin was studied in 5 healthy adult laboratory rabbits of both sexes. Gentamicin sulfate (5% aqueous solution) was administered rapidly (IV) at a dosage of 3 mg/kg of body weight. Venous blood samples were taken at 0 (baseline), 5, 10, 15, and 30 minutes, and 1, 1.5, 2, 2.5, 3, 4, 5, and 6 hours after gentamicin administration. Serum gentamicin concentration was measured by radioimmunoassay. With the aid of a nonlinear least-squares program, the gentamicin concentration data were found to be best described by a 2-compartment model, with r2 = 0.989. Half-life, as determined from the terminal phase, was 56.6 +/- 2.4 (mean +/- SD) minutes. Calculation of total body clearance provided a mean of 1.69 +/- 0.07 ml/min/kg of body weight. Volume of distribution, calculated from the area under the curve for each animal, was 0.138 +/- 0.005 L/kg.
Curl
J L
JL
Department of Physiology, School of Medicine, Southern Illinois University, Carbondale 62901.
Curl
J S
JS
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D011817:Rabbits / Q000378:metabolism*; D011863:Radioimmunoassay / Q000662:veterinary
D005839:Gentamicins