Transfusion-induced specific anti-factor XI inhibitor in a patient with previously unrecognized factor XI deficiency.
This article reports the rare occurrence and investigation of a specific anti-factor XI inhibitor that arose after fresh-frozen plasma infusion into a patient with previously unrecognized Factor XI deficiency. The IgG fraction of the patient's plasma that contained anti-Factor XI antibody was isolated by chromatography on DEAE-Affigel and concentrated. It was shown to exert inhibitory effect on purified Factor XI and XIa both in the activated and nonactivated partial thromboplastin time assay.
Musclow
C E
CE
Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada.
Amato
D
D
Ofosu
F
F
Armstrong
A L
AL
Abbott
D
D
D000368:Aged; D001780:Blood Coagulation Tests; D005172:Factor XI / Q000037:antagonists & inhibitors*; D005173:Factor XI Deficiency / Q000097:blood* / Q000175:diagnosis; D015945:Factor XIa; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000502:physiology; D065227:Transfusion Reaction
D007074:Immunoglobulin G; D005172:Factor XI; D015945:Factor XIa