1,2,3,4,-Tetrahydro-1,2-diazepine derivatives: synthesis and evaluation of antileukemic activity.
A series of 3-aryl or etheroaryl-6-cyano-7-phenyl-1,2,3,4-tetrahydro-1,2-diazepin- 5-ones was synthesized and evaluated for its antitumor activity against P388 leukemic tumor system in mice. None of the tested compounds showed significant antitumor properties.
Dal Piaz
V
V
Dipartimento di Scienze Farmaceutiche, Università di Firenze, Italy.
Ciciani
G
G
D000818:Animals; D000970:Antineoplastic Agents; D001381:Azepines / Q000138:chemical synthesis* / Q000627:therapeutic use; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice; D009570:Nitriles / Q000138:chemical synthesis* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D001381:Azepines; D009570:Nitriles