Comparative effects of 1-ethyl- and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridines on catecholamine concentrations in mouse brain and heart.
The effects of 1-ethyl-4-phenyl-1,2,3,6-tetrahydropyridine (EPTP) on striatal dopamine, cortical norepinephrine and cardiac norepinephrine concentrations in mice were compared to the effects of the 1-methyl analog (MPTP). One week after the last of four daily injections of MPTP into mice, persistent depletion of dopamine and its metabolites in the striatum and of norepinephrine in the frontal cortex was found. EPTP did not produce these effects even at doses up to 4 times those of MPTP. A single dose of MPTP depleted cardiac norepinephrine 24 hrs later in mice. EPTP and the corresponding pyridinium compound (EPP+) depleted cardiac norepinephrine to a similar extent as did MPTP. These results and earlier observations show differences between the characteristics of MPTP-induced depletion of brain catecholamines and those of MPTP-induced depletion of cardiac norepinephrine.
Fuller
R W
RW
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285.
Hemrick-Luecke
S K
SK
Robertson
D W
DW
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000031:analogs & derivatives; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D011725:Pyridines / Q000494:pharmacology*
D002395:Catecholamines; D011725:Pyridines; C055389:1-ethyl-4-phenyl-1,2,3,6-tetrahydropyridine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine; D009638:Norepinephrine