A non-invasive method of blood glucose evaluation by tear glucose measurement, for the detection and control of diabetic states.
The development of a quick, simple and sufficiently reliable method for tear glucose measurement is described. The method, based on a color reaction with triphenyl-tetrazolium chloride on special filter paper strips imbibed with tears, showed results which related favorably with parallel blood glucose levels of the same patients, already in the first stage of its development. Being non-invasive, the proposed method could be of important practical benefit for the detection and monitoring of diabetics, thus obviating the necessity of invasive blood sampling inherent to existing biochemical techniques. The second stage of development of tear glucose measurement, consisting of improvement and perfection of the technique, gave very encouraging results until now.
Romano
A
A
Maurice and Gabriela Goldschleger Eye Institute, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Rolant
F
F
D001786:Blood Glucose / Q000032:analysis*; D003920:Diabetes Mellitus / Q000175:diagnosis*; D005947:Glucose / Q000032:analysis*; D006801:Humans; D013666:Tears / Q000032:analysis*; D013778:Tetrazolium Salts / Q000378:metabolism
D001786:Blood Glucose; D013778:Tetrazolium Salts; C009591:triphenyltetrazolium; D005947:Glucose