title: Immune response to ultraviolet-induced tumors. III. Analysis of cloned lymphocyte populations exhibiting antitumor activity.
abstract: Previously, we hypothesized that natural killer lymphocytes could function as effector cells in the rejection of UV-induced tumors in tumor-immune animals. Immunization with progressor UV-tumor 2237 induced lymphocytes exhibiting natural cell-mediated cytotoxicity but failed to elicit tumor-specific cytolytic T lymphocytes. In the present investigation, T lymphocyte cloning technology provided a means of isolating homogeneous lymphocyte populations exhibiting CTL and NK activities. Clones with both CTL and NK activity were isolated from regressor-1316-immune mice, but NK-like clones only were isolated from progressor-2237-immune mice. An evaluation of the in situ anti-UV-tumor action of a representative NK lymphocyte clone revealed that these cells could in fact prevent tumor outgrowth, supporting our hypothesis that these cells could function as effector cells in UV-tumor rejection responses in tumor-immune animals.
authors.affiliation: Division of Biology, Kansas State University, Manhattan 66506.
authors.forename: P R
authors.initials: PR
authors.lastname: Streeter
authors.forename: G W
authors.initials: GW
authors.lastname: Fortner
mesh_terms: D000818:Animals; D000943:Antigens, Differentiation / Q000032:analysis; D002999:Clone Cells; D003602:Cytotoxicity, Immunologic; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D009381:Neoplasms, Radiation-Induced / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014466:Ultraviolet Rays
chemical_list: D000943:Antigens, Differentiation