Experimental and clinical studies on epidermal growth factor for gastric mucosal protection and healing of gastric ulcers.
In experimental studies, 0.6 N HCl-induced gastric mucosal injury was significantly severe in submandibularectomized rats (SMR rats) than that in either SMR rats receiving exogenous mouse EGF (SMR + EGF rats) or controls. This was also true in gastric injury induced by 0.4 N HCl under pretreatment with indomethacin to reduce gastric mucosal prostaglandins (PGs). Somatostatin (SLI), PGE2, and PAS-stained mucus in the corpus were significantly reduced in SMR rats in comparison to SMR + EGF and control rats. In clinical studies, salivary EGF secretion was much higher in peptic ulcer patients than healthy controls. beta-Urogastrone was effective in the treatment of gastric ulcers. On the basis of experimental studies, we conclude that the protective effect of EGF on the gastric mucosa is, in part, mediated indirectly by increases in SLI, PGE2, and mucus production. However, endogenous, as well as exogenous, EGF has an important direct, cytoprotective effect on the gastric mucosa. From the clinical studies, we also conclude that salivary EGF secretion in ulcer patients increases in a homeostatic response to the presence of an ulcer, facilitating ulcer healing. Furthermore, we believe that beta-urogastrone, human EGF, might prove to be an effective drug in the clinical treatment of gastric ulcers.
Itoh
M
M
First Department of Internal Medicine, Nagoya City University, School of Medicine, Japan.
Joh
T
T
Imai
S
S
Miyamoto
T
T
Matsusako
K
K
Iwai
A
A
Katsumi
K
K
Endo
K
K
Goto
K
K
Takeuchi
T
T
D000818:Animals; D004815:Epidermal Growth Factor / Q000494:pharmacology / Q000502:physiology*; D005753:Gastric Mucosa / Q000502:physiology*; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012463:Saliva / Q000502:physiology; D012472:Salivation; D013276:Stomach Ulcer / Q000503:physiopathology*
D004815:Epidermal Growth Factor