Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor.
To clarify the possible role of TNF and IL-1 in endotoxic shock, the lethality of rTNF (human and murine) and IL-1 in adrenalectomized mice was studied. Adrenalectomy, which has long been known to increase the susceptibility to endotoxin, rendered mice susceptible to TNF and IL-1 in terms of mortality. The lethality of endotoxin, TNF, or IL-1 was totally prevented by pretreatment with dexamethasone (minimal effective dose, 0.3 mg/Kg) but not by ibuprofen (10 mg/Kg).
Bertini
R
R
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Bianchi
M
M
Ghezzi
P
P
D000302:Adrenal Cortex / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use; D007052:Ibuprofen / Q000494:pharmacology / Q000627:therapeutic use; D007375:Interleukin-1 / Q000633:toxicity*; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D051379:Mice; D011994:Recombinant Proteins / Q000633:toxicity; D012769:Shock / Q000139:chemically induced / Q000503:physiopathology* / Q000517:prevention & control; D012772:Shock, Septic / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000633:toxicity*
D007375:Interleukin-1; D008070:Lipopolysaccharides; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D003907:Dexamethasone; D007052:Ibuprofen