[New in vitro procedures in allergy diagnosis].
The diagnosis of IgE-mediated allergies is mainly based on anamnesis, skin test and antigen challenge. In some situations however, described in the text, skin test keeps in the background and serological antibody-identification becomes more and more important. This development is clearly illustrated by the example of patients suffering from neurodermatitis: since the introduction of appropriate screening-methods atopic organ manifestations of the patients are noticed significantly more often than before. All laboratory for the serological diagnoses of allergies, including completely new methods, are described and checked up for useful criteria of interpretation. For this purpose the statistical data of more than 20,000 persons, suffering from atopy were reviewed. Finally, both the variations of the IgE-level, including possible consequences, and the increased occurrence of cross-sensitivities between inhalational and ingestive antigens are discussed.
Düngemann
H
H
Abteilung Allergie der Dermatologischen Klinik und Poliklinik der TU München.
D000941:Antigens / Q000276:immunology; D001249:Asthma / Q000175:diagnosis; D003876:Dermatitis, Atopic / Q000175:diagnosis; D005512:Food Hypersensitivity / Q000175:diagnosis; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D007073:Immunoglobulin E / Q000032:analysis*; D007428:Intradermal Tests; D011852:Radioallergosorbent Test / Q000379:methods; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis; D012698:Serologic Tests / Q000379:methods*
D000941:Antigens; D007073:Immunoglobulin E
Neue in-vitro-Verfahren zur Allergiediagnostik.