title: Frequencies of chromosomal aberrations induced in human blood lymphocytes by low doses of X-rays.
abstract: The dose-response for radiation-induced chromosome aberrations in human lymphocytes is usually fitted to the quadratic model. This assumes that the slope is essentially linear at low doses. Empirical observations of linearity at less than 200 mGy are, however, sparse. Some data have been published indicating a non-linear (threshold) response and these are reviewed. In particular one study with X-rays showed a plateau in response up to 50 mGy and with a significant dip below the control level at 4 mGy. The mechanism proposed to explain non-linearity is that low doses stimulate the enzymic repair capability of lymphocytes. Preliminary data are presented from a large experiment by six laboratories in which the low dose-response for X-rays has been re-examined. The plateau in the dose-response relationship, if it exists, does not extend to doses above approximately 10 mGy. No irradiated cells yielded aberration levels significantly below the control. Over the range 0-300 mGy the response can be fitted to a linear regression. There are, however, variations in sensitivity between cells from different donors. An unexpected finding was that some lymphocytes contained greater than 1 exchange aberrations. This may indicate a small subset of cells that are especially susceptible to the induction of aberrations by low doses.
authors.affiliation: CEN/SCK, Mol, Belgium.
authors.forename: D C
authors.initials: DC
authors.lastname: Lloyd
authors.forename: A A
authors.initials: AA
authors.lastname: Edwards
authors.forename: A
authors.initials: A
authors.lastname: Léonard
authors.forename: G
authors.initials: G
authors.lastname: Deknudt
authors.forename: A
authors.initials: A
authors.lastname: Natarajan
authors.forename: G
authors.initials: G
authors.lastname: Obe
authors.forename: F
authors.initials: F
authors.lastname: Palitti
authors.forename: C
authors.initials: C
authors.lastname: Tanzarella
authors.forename: E J
authors.initials: EJ
authors.lastname: Tawn
mesh_terms: D000328:Adult; D002842:Chromatids / Q000528:radiation effects; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects* / Q000648:ultrastructure; D008297:Male; D011836:Radiation Tolerance