Effect of calcitonin on hepatic drug metabolism.
A single dose of calcitonin (150 mIU/100 g body weight, sc) produced a significant decrease in liver antipyrine hydroxylase and aminopyrine demethylase activities. By contrast, pentobarbital sleeping time was not altered by calcitonin treatment. The present results indicate that acute calcitonin administration depresses the metabolism of substrates of the mixed function oxidase system of rat liver.
Godinho
A F
AF
Departamento de Ciências Fisiológicas, Instituto de Biologia, Universidade Estadual do Rio de Janeiro, Brasil.
Cavalcante
G J
GJ
Machado
M G
MG
Faria
T F
TF
Gil
T C
TC
Coutinho
R B
RB
Garcia
C
C
D000633:Aminopyrine N-Demethylase / Q000378:metabolism*; D000818:Animals; D000983:Antipyrine / Q000378:metabolism; D002116:Calcitonin / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010424:Pentobarbital / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects
C028815:salmon calcitonin; D002116:Calcitonin; D006899:Mixed Function Oxygenases; D000633:Aminopyrine N-Demethylase; D010424:Pentobarbital; D000983:Antipyrine