title: Survival of adenohypophyseal homologous transplants in the rat striatum associated with prolactin-like immunoreactivity in the surrounding neuropil of the striatum.
abstract: By means of Cresyl violet stainings and immunocytochemical studies on prolactin-, luteinizing hormone (LH)-, and adrenocorticotropin (ACTH)-like immunoreactivities evidence has been obtained that homologous adenohypophyseal transplants survive for many weeks in the rat neostriatum. Gland cells maintain their endocrine properties and appear to secrete prolactin but not ACTH and LH into the surrounding neuropil of the rat neostriatum, since it contains a strong diffuse prolactin-like immunoreactivity. The diffuse zone of prolactin-like immunoreactivity disappears following inhibition of prolactin secretion by the dopamine agonist bromocriptine. The results support the existence of volume transmission in brain and offer a model for its analysis.
authors.affiliation: Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Bjelke
authors.forename: K
authors.initials: K
authors.lastname: Fuxe
authors.forename: L F
authors.initials: LF
authors.lastname: Agnati
mesh_terms: D000818:Animals; D003342:Corpus Striatum; D005260:Female; D006085:Graft Survival; D007150:Immunohistochemistry; D008297:Male; D010903:Pituitary Gland, Anterior / Q000378:metabolism / Q000637:transplantation*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011388:Prolactin