title: B prolymphocytic leukemia cell lines: phenotype and response to B cell differentiation factor.
abstract: Three recently-derived cell lines of prolymphocytic leukemia origin were studied. The phenotype of the cells, analysed in terms of expression of immunoglobulin and other B cell maturation markers, indicates that the cells are mature B lymphocytes close to the plasma cell stage of differentiation. All three cell lines secrete IgM, and two of the three lines respond to B cell differentiation factor with an increased secretion of IgM.
authors.affiliation: Department of Clinical Immunology, Flinders Medical Centre, Bedford Park, South Australia.
authors.forename: H
authors.initials: H
authors.lastname: Zola
authors.forename: V
authors.initials: V
authors.lastname: Furness
authors.forename: A
authors.initials: A
authors.lastname: Nikoloutsopoulos
authors.forename: J
authors.initials: J
authors.lastname: Bradley
authors.forename: J V
authors.initials: JV
authors.lastname: Melo
authors.forename: D
authors.initials: D
authors.lastname: Catovsky
mesh_terms: D000944:Antigens, Differentiation, B-Lymphocyte; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D002454:Cell Differentiation; D002460:Cell Line; D006680:HLA Antigens; D006801:Humans; D007136:Immunoglobulins; D015847:Interleukin-4; D007378:Interleukins / Q000494:pharmacology*; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000473:pathology; D010641:Phenotype; D014407:Tumor Cells, Cultured / Q000276:immunology / Q000473:pathology
chemical_list: D000944:Antigens, Differentiation, B-Lymphocyte; D006680:HLA Antigens; D007136:Immunoglobulins; D007378:Interleukins; D015847:Interleukin-4