Effects of interleukin-2 on oxygen delivery and consumption in patients with advanced malignancy.
We evaluated the effects of fluid challenges on oxygen delivery (DO2) and oxygen consumption (VO2) in nine patients receiving immunotherapy with interleukin-2. Fluid resuscitation produced an increase in DO2 from 15.7 +/- 3.1 to 17.4 +/- 3.5 ml/min/kg (mean +/- SD, p less than 0.001), which was associated with a corresponding increase in VO2, from 2.8 +/- 0.7 to 3.1 +/- 0.6 ml/min/kg (p less than 0.01). These results suggest that oxygen consumption may be dependent on oxygen delivery in patients on IL-2 therapy. The presence of oxygen supply dependency may contribute to the multiple organ failure observed with IL-2 administration.
Silverman
H J
HJ
Department of Medicine, University of Maryland Medical System, Baltimore.
Abrams
J
J
Rubin
L J
LJ
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002496:Central Venous Pressure; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011669:Pulmonary Wedge Pressure; D014655:Vascular Resistance
D007376:Interleukin-2; D010100:Oxygen