title: [Effect of sex steroids on the lipoprotein profile].
abstract: Hyperandrogenemia is associated with relatively high LDL- and low HDL-cholesterol levels, increasing the risk of the development of arteriosclerotic disease. In three women suffering from androgen producing ovarian tumors, this observation could be confirmed. After surgical removal of the ovaries, lipoprotein profiles returned to normal. In contrast, androgens did not affect lipoproteins in two testicular feminized individuals. Despite elevated testosterone levels, the lipoprotein profiles were absolutely normal. This observation indicates that the affects on the lipoprotein profile is receptor mediated.
authors.affiliation: Abt. Klinische Endokrinologie der Universitäts-Frauenklinik Freiburg.
authors.forename: H J
authors.initials: HJ
authors.lastname: Prömpeler
authors.forename: J
authors.initials: J
authors.lastname: Neulen
authors.forename: P
authors.initials: P
authors.lastname: Wieacker
authors.forename: H P
authors.initials: HP
authors.lastname: Zahradnik
authors.forename: M
authors.initials: M
authors.lastname: Breckwoldt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D013734:Androgen-Insensitivity Syndrome / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007984:Leydig Cell Tumor / Q000097:blood* / Q000601:surgery; D008074:Lipoproteins / Q000097:blood*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood* / Q000601:surgery; D010052:Ovariectomy; D009384:Paraneoplastic Endocrine Syndromes / Q000097:blood*; D014770:Virilism / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008074:Lipoproteins
vernacular_title: Zur Wirkung von Sexualsteroiden auf das Lipoproteinprofil.