title: The effect of iodide depletion and supplementation in the Buffalo strain rat.
abstract: We have investigated the effect of excess iodide alone, following iodide depletion or in conjunction with a mild thyroid insult (trypan blue) in Buffalo strain rats, which are genetically susceptible to experimental autoimmune thyroiditis. In all three cases a high iodine diet led to enhanced thyroglobulin antibody production, usually accompanied by worsening of the severity of thyroiditis. Moreover, the administration of a normal iodine diet after iodide depletion resulted in thyroglobulin antibody formation. These results provide further support for a role for dietary iodine in modulating experimental autoimmune thyroiditis with implications for human thyroid autoimmunity.
authors.affiliation: University of Cambridge, Department of Medicine, United Kingdom.
authors.forename: S B
authors.initials: SB
authors.lastname: Cohen
authors.forename: A P
authors.initials: AP
authors.lastname: Weetman
mesh_terms: D000818:Animals; D004032:Diet; D005260:Female; D007455:Iodine / Q000008:administration & dosage* / Q000172:deficiency / Q000493:pharmacokinetics; D008297:Male; D051381:Rats; D011915:Rats, Inbred BUF / Q000378:metabolism*; D011919:Rats, Inbred Strains / Q000378:metabolism*; D013961:Thyroid Gland / Q000187:drug effects; D013966:Thyroiditis / Q000139:chemically induced; D014343:Trypan Blue / Q000494:pharmacology
chemical_list: D007455:Iodine; D014343:Trypan Blue