Growth factor involvement and oncogene expression in prostatic tumours.
The effects of EGF, TGF alpha and 5 alpha-dihydrotestosterone on the growth of a prostatic epithelial cell line have been evaluated in clonal growth assays. Similar bioassay systems have been used to identify tumour-associated growth promoters derived from a human prostatic carcinoma cell line (PC3). Growth factor activity was associated with proteins of Mr 20-30 kDa. In a separate study, EGF receptor concentration and cellular proto-oncogene expression was assessed in prostatic tumour samples. In prostatic carcinoma samples, strong correlation was observed between EGF receptor concentration and c-myc expression. There were no significant correlations between EGF receptor concentration and tumour grade or androgen receptor content in carcinoma samples. EGF receptor concentration was significantly higher in prostatic carcinoma specimens than in BPH.
Eaton
C L
CL
Tenovus Institute for Cancer Research, University of Wales College of Medicine, Heath Park, Cardiff.
Davies
P
P
Phillips
M E
ME
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002999:Clone Cells; D013196:Dihydrotestosterone / Q000494:pharmacology*; D004285:Dogs; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D066246:ErbB Receptors / Q000378:metabolism; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009857:Oncogenes; D010455:Peptides / Q000494:pharmacology*; D011467:Prostate; D011471:Prostatic Neoplasms; D000090063:Proto-Oncogene Mas; D015291:Transforming Growth Factors
D006133:Growth Substances; C000715470:MAS1 protein, human; D010455:Peptides; D000090063:Proto-Oncogene Mas; D013196:Dihydrotestosterone; D004815:Epidermal Growth Factor; D015291:Transforming Growth Factors; D066246:ErbB Receptors