Pharmacologic modulation of acute ocular inflammation. I. Adenosine.
Modulation of signal transduction at the surface of inflammatory cells appears to influence acute inflammation. Adenosine, a well-known chemical messenger, inhibits the production of superoxide by stimulated neutrophils. In experimental allergic uveitis induced by sensitization with retinal 's' antigen, treatment with adenosine produced a marked reduction in the expected inflammation.
Marak
G E
GE
Center for Sight, Georgetown University, Washington, D.C.
de Kozak
Y
Y
Faure
J P
JP
Rao
N A
NA
Romero
J L
JL
Ward
P A
PA
Till
G O
GO
D000241:Adenosine / Q000627:therapeutic use*; D000818:Animals; D000941:Antigens / Q000276:immunology; D019393:Arrestin; D002829:Choroid / Q000473:pathology; D002833:Choroiditis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D005136:Eye Proteins / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D012160:Retina / Q000473:pathology; D012173:Retinitis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D014605:Uveitis / Q000188:drug therapy* / Q000276:immunology
D000941:Antigens; D019393:Arrestin; D005136:Eye Proteins; D000241:Adenosine