title: [Clinical picture and course of children with CHARGE association].
abstract: Four children are described who presented malformations according to CHARGE-Association. The primary abnormalities were choanal atresia and/or Coloboma. All four cases exhibited esophageal malformations: atresia and/or fistulas. At autopsy, three children showed arhinencephaly which is rarely observed in patients with CHARGE-Association. Patients with the main features of CHARGE-Association have a very poor prognosis depending on the severity of the malformations.
authors.affiliation: Kinderneurologisches Zentrum des Landes Rheinland Pfalz, Institut für Soziale Pädiatrie, Mainz.
authors.forename: H
authors.initials: H
authors.lastname: Peters
authors.forename: B F
authors.initials: BF
authors.lastname: Pontz
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis; D002657:Child Development; D002754:Choanal Atresia / Q000175:diagnosis*; D003103:Coloboma / Q000175:diagnosis*; D004933:Esophageal Atresia / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D013577:Syndrome
vernacular_title: Klinisches Bild und Verlauf von Kindern mit CHARGE-Association.