Possible synergism between fluoxetine and lithium in refractory depression.
Five depressed patients who had shown no improvement with trials of antidepressants from several chemical families, including fluoxetine, responded when lithium was given in conjunction with fluoxetine. Lithium augmentation of fluoxetine may represent a useful strategy in refractory depression.
Pope
H G
HG
Epidemiology Laboratory, McLean Hospital, Belmont, MA 02178.
McElroy
S L
SL
Nixon
R A
RA
D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D008297:Male; D011437:Propylamines / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales
D011437:Propylamines; D005473:Fluoxetine; D008094:Lithium