title: Increase in antideoxyribonucleic acid antibody titer in postpartum aggravation of autoimmune thyroid disease.
abstract: Serum antidouble stranded DNA antibody levels were measured during pregnancy and after delivery in women who had postpartum exacerbations of Graves' and Hashimoto's diseases. The changes in serum anti-DNA antibody levels closely paralleled those in the serum free T4 index, significantly increasing in the thyrotoxic phase 3-8 months postpartum in women with postpartum exacerbations of thyrotoxicosis due to Graves' disease and 1-3 months postpartum in women with postpartum destructive thyrotoxicosis of Graves' and Hashimoto's diseases. No change in anti-DNA antibody level was found in women with no postpartum exacerbations of thyroid diseases, nor could we demonstrate significant increases in serum anti-DNA antibody titers in patients with thyrotoxicosis due to subacute thyroiditis or in normal pregnant and postpartum women. The changes in serum anti-DNA antibody titers may reflect some generalized immunological abnormality in women who have postpartum exacerbations of Graves' or Hashimoto's diseases.
authors.affiliation: Department of Laboratory Medicine, Osaka University Medical School, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Tachi
authors.forename: N
authors.initials: N
authors.lastname: Amino
authors.forename: Y
authors.initials: Y
authors.lastname: Iwatani
authors.forename: H
authors.initials: H
authors.lastname: Tamaki
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: M
authors.initials: M
authors.lastname: Aozasa
authors.forename: O
authors.initials: O
authors.lastname: Tanizawa
authors.forename: K
authors.initials: K
authors.lastname: Miyai
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D004247:DNA / Q000276:immunology*; D005260:Female; D006111:Graves Disease / Q000276:immunology; D006801:Humans; D011247:Pregnancy; D011644:Puerperal Disorders / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000276:immunology*; D013971:Thyrotoxicosis / Q000276:immunology
chemical_list: D000974:Antibodies, Antinuclear; D004247:DNA