[Effect of sodium selenite and its combination with remantadine on the synthesis of virus-specific polypeptides in a cell culture infected with influenza A virus].
The combined effects of sodium selenite and remantadine on synthesis of virus-specific polypeptides in influenza A virus-infected CEC cells are described. The pattern of selenium distribution in subcellular fractions and biomacromolecules of different organs of rats was established. Combined use of sodium selenite and remantadine actively inhibits synthesis of influenza A virus polypeptides which is of synergistic nature.
Abdullaev
I I
II
Asadullaev
T B
TB
Abdullaev
F I
FI
D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D000998:Antiviral Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002642:Chick Embryo; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000378:metabolism; D010452:Peptide Biosynthesis; D010455:Peptides / Q000037:antagonists & inhibitors; D051381:Rats; D012299:Rimantadine / Q000627:therapeutic use*; D020887:Selenious Acid; D012643:Selenium / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012644:Selenium Radioisotopes; D014018:Tissue Distribution; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D014776:Virus Cultivation
D000998:Antiviral Agents; D010455:Peptides; D012644:Selenium Radioisotopes; D014764:Viral Proteins; D012299:Rimantadine; D020887:Selenious Acid; D012643:Selenium; D000218:Adamantane
Vliianie selenita natriia i ego kombinatsii s remantadinom na sintez virusspetsificheskikh polipeptidov v kul'ture kletok, infitsirovannykh virusom grippa A.