Noninvasive follow-up study in hypertrophic obstructive cardiomyopathy.
The clinical course of hypertrophic cardiomyopathy with left ventricular outflow obstruction showed a symptomatic progression in 25% of patients, independent of the of degree of left ventricular obstruction. Echocardiographic and mechanocardiographic examinations showed a close relationship between severity of asymmetric ventricular hypertrophy and diastolic failure. During the follow-up septal hypertrophy became more severe without left ventricular dilatation. Global diastolic function deteriorated and the left atrium dilated. The probability of survival was 67.2%. Our data suggest that septum hypertrophy and diastolic dysfunction are progressive in HOCM. The mortality is independent of the severity of hypertrophy and diastolic dysfunction, and shows a close correlation with arrhythmias.
Cserhalmi
L
L
Hungarian Institute of Cardiology, Budapest.
Szabóky
F
F
Ilovszky
Z
Z
Csukás
A
A
Huszár
G
G
D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000401:mortality / Q000473:pathology / Q000503:physiopathology*; D003645:Death, Sudden / Q000453:epidemiology; D004452:Echocardiography; D004562:Electrocardiography; D005500:Follow-Up Studies; D006801:Humans; D007702:Kinetocardiography; D011379:Prognosis