Carcinogenic and non-carcinogenic fluorene derivatives: induction of thymocyte stimulating serum factors by 2-acetylaminofluorene (AAF) and their synergy with lymphocyte mitogens.
Recent experiments have shown that AAF induces serum factors which stimulate the replicating DNA synthesis of normal rat thymocyte in vitro. In this respect fluorene as well as carcinogenic and non-carcinogenic derivatives were assayed. A proliferative response is only produced by the serum of AAF-treated rats (AAF-serum). Moreover, this serum acts synergistically with the lymphocyte mitogens Con A and PHA. Growth factors similar to those in serum of liver regenerating rats are supposed to be responsible.
Danz
M
M
Friedrich Schiller University Jena, Institute of Pathology, DDR.
Bräuer
R
R
D015073:2-Acetylaminofluorene / Q000494:pharmacology*; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects*; D004357:Drug Synergism; D005449:Fluorenes / Q000494:pharmacology*; D006133:Growth Substances / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008934:Mitogens / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013329:Structure-Activity Relationship
D002273:Carcinogens; D005449:Fluorenes; D006133:Growth Substances; D008934:Mitogens; D015073:2-Acetylaminofluorene