title: Changes in cortical thickness of the clavicle and serum bone gamma-carboxyglutamic acid-containing protein in the elderly in an island community in western Japan.
abstract: The cortical thickness of the clavicle (CTC), concentrations of bone gamma-carboxyglutamic acid-containing (Gla) protein (s-BGP, osteocalcin), alkaline phosphatase (s-ALP), calcium (s-Ca) and inorganic phosphorus (s-P) in serum, and calcium/creatinine (u-Ca/Cr) and inorganic phosphorus/creatinine (u-P/Cr) ratios in urine were examined in 211 subjects aged over 40 years in Oshima Island in Nagasaki prefecture. CTC decreased and s-BGP increased with age in both sexes, especially in women. Serum BGP was significantly higher in women than in men at the ages of 50's and over. Serum ALP in women increased until the ages of 60's. Serum Ca at the ages of 50's and s-P at the ages of 60's and over were higher in women than in men. As the increase in s-BGP is reported to be coincident with active bone formation, our findings do not support the view that age-related bone loss, especially in women, primarily results from decrease in bone formation.
authors.affiliation: Department of Public Health, Nagasaki University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Aoyagi
authors.forename: T
authors.initials: T
authors.lastname: Takemoto
authors.forename: K
authors.initials: K
authors.lastname: Moji
mesh_terms: D015055:1-Carboxyglutamic Acid / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000473:pathology*; D000469:Alkaline Phosphatase / Q000097:blood; D002968:Clavicle / Q000254:growth & development* / Q000378:metabolism; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000097:blood / Q000652:urine; D012737:Sex Factors
chemical_list: D008903:Minerals; D015055:1-Carboxyglutamic Acid; D000469:Alkaline Phosphatase