Flow-dependent dilation in a resistance artery still occurs after endothelium removal.
Infusion of physiological saline solution into the lumen of a tonically contracted resistance artery in vitro caused active relaxation. After endothelium removal by rubbing, confirmed by scanning electron microscopy and loss of the relaxation response to acetylcholine (1 microM), flow relaxation was reduced from a mean of 70% to 37%. The latter change was significant (p less than 0.01). It is concluded that flow-relaxation in the resistance artery of the rabbit originates from both the tunica intima and the media.
Bevan
J A
JA
Department of Pharmacology, University of Vermont, Burlington 05405.
Joyce
E H
EH
Wellman
G C
GC
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000502:physiology; D001685:Biological Factors / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology* / Q000648:ultrastructure; D066298:In Vitro Techniques; D009569:Nitric Oxide; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D012039:Regional Blood Flow; D013314:Stress, Mechanical; D014655:Vascular Resistance; D014664:Vasodilation / Q000187:drug effects
D001685:Biological Factors; D009569:Nitric Oxide; D000109:Acetylcholine; D009638:Norepinephrine