Pharmacokinetics of LY163892 in infants and children.
Two dosages (7.5 and 15 mg/kg of body weight) of LY163892 were given to infants and children, and five plasma specimens were collected for antibiotic assay during the ensuing 4 h. Peak concentrations of 12.6 and 18.7 micrograms/ml occurred at 45 min. The mean half-lives were 0.85 and 0.78 h, and the mean areas under the curve were 24.4 and 38.0 micrograms.h/ml.
Nelson
J D
JD
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063.
Shelton
S
S
Kusmiesz
H
H
D000293:Adolescent; D002511:Cephalosporins / Q000097:blood / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006207:Half-Life; D006801:Humans; D007223:Infant; D008297:Male; D008657:Metabolic Clearance Rate
D002511:Cephalosporins; C054920:loracarbef