Pharmacological evaluation of prophylactic anti-asthma drugs by reference to the pathological sequelae of exposure to allergen or platelet activating factor.
Exposure of guinea-pigs to platelet activating factor (PAF) induces airway hyperreactivity and causes an influx of eosinophils into the airways. These effects are inhibited by the established prophylactic anti-asthma drugs; cromoglycate, aminophylline, glucocorticosteroids and ketotifen, whereas other drug categories, with the exception of PAF-receptor antagonists, are ineffective.
Morley
J
J
Sandoz AG, Preclinical Research, Basle, Switzerland.
Sanjar
S
S
Boubekeur
K
K
Aoki
S
S
Kristersson
A
A
D000485:Allergens; D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000209:etiology; D004341:Drug Evaluation; D004802:Eosinophilia / Q000188:drug therapy / Q000209:etiology; D006168:Guinea Pigs; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors* / Q000502:physiology; D012137:Respiratory System / Q000187:drug effects
D000485:Allergens; D010972:Platelet Activating Factor