title: Magnetic resonance imaging in Pelizaeus-Merzbacher disease.
abstract: Cranial computed tomography of a boy with clinical characteristics of the classic form of Pelizaeus-Merzbacher disease did not reveal a notable abnormality other than enlarged ventricles. Magnetic resonance imaging, however, demonstrated diffuse changes in the white matter with sparing of scattered small areas, suggesting persistent myelin islands which are a typical neuropathologic finding in Pelizaeus-Merzbacher disease. Magnetic resonance imaging appears more useful than computed tomography in confirming the diagnosis of Pelizaeus-Merzbacher disease.
authors.affiliation: Department of Pediatrics, Tokyo Children's Rehabilitation Hospital, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Shimomura
authors.forename: A
authors.initials: A
authors.lastname: Matsui
authors.forename: H
authors.initials: H
authors.lastname: Choh
authors.forename: M
authors.initials: M
authors.lastname: Funahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Tsuchiya
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009186:Myelin Sheath / Q000473:pathology*