[Emetic and catalepsy-inducing actions of buflomedil].
The emetic and catalepsy-inducing actions of buflomedil were studied in dog and mice. Oral administration of buflomedil (10-30 mg/kg) dose-dependently induced vomiting in dogs. On the other hand, the buflomedil-induced vomiting was inhibited by the pretreatment with domperidone (1 mg/kg, p.o.). A high dose of buflomedil (120-360 mg/kg, p.o.) induced catalepsy in mice, while a low dose of this agent (30-120 mg/kg, p.o.) had no enhancing effect on haloperidol-induced catalepsy. It was also found that the buflomedil-induced catalepsy was inhibited by the pretreatments with L-DOPA (300 mg/kg, i.p.) and bromocriptine (5 mg/kg, i.p.), respectively. These results suggest that buflomedil may induce emetic action as a dopamine agonist at a low dose, whereas it acts as a dopamine antagonist and a catalepsy inducer at a high concentration.
Koda
H
H
Kyoto Prefectural University of Medicine, Japan.
Hashimoto
T
T
Kuriyama
K
K
D000284:Administration, Oral; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced*; D004285:Dogs; D004294:Domperidone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051379:Mice; D011759:Pyrrolidines / Q000008:administration & dosage / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D014839:Vomiting / Q000139:chemically induced*
D011759:Pyrrolidines; D001971:Bromocriptine; D007980:Levodopa; D004294:Domperidone; C010651:buflomedil