title: Epidermal growth factor stimulates phosphatidylinositol turnover for ten hours in A431 cells without activation of protein kinase C.
abstract: Epidermal Growth Factor stimulated phosphatidylinositol turnover in A431 cells for up to ten hours. There was an increase in phosphatidylinositol, phosphatidylinositol-4-phosphate, phosphatidylinositol-4,5-bisphosphate and phosphatidic acid at all time points. The effects on the inositol phosphates were variable. Despite the activation of the phosphatidylinositol cycle, we were unable to demonstrate activation of protein kinase C.
authors.affiliation: Dept. of Medicine, University Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: D M
authors.initials: DM
authors.lastname: Thompson
authors.forename: J
authors.initials: J
authors.lastname: Proctor
authors.forename: M
authors.initials: M
authors.lastname: Grant
authors.forename: C
authors.initials: C
authors.lastname: Thomas
mesh_terms: D000818:Animals; D002460:Cell Line; D004789:Enzyme Activation; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D013997:Time Factors
chemical_list: D010716:Phosphatidylinositols; D004815:Epidermal Growth Factor; D011493:Protein Kinase C