Synthesis and antimicrobial activity of some N-monosubstituted 2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamides.
A short series of N-monosubstituted (aryl, aminoacyl, dipeptidyl)-2-(2-aminothiazol-4-yl)-(Z) -2-methoxyiminoacetamides was synthesized and tested for antimicrobial activity. A few members showed a somewhat interesting inhibitory action against Cryptococcus neoformans (MIC = 150 micrograms/ml).
Garuti
L
L
Department of Pharmaceutical Science, University of Fermentation Chemistry, Faculty of Pharmacy, Bologna, Italy.
Ferranti
A
A
Varoli
L
L
Giovanninetti
G
G
Brigidi
P
P
D000081:Acetamides / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000081:Acetamides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D013844:Thiazoles