title: Haloperidol blocks the response-reinstating effects of food reward: a methodology for separating neuroleptic effects on reinforcement and motor processes.
abstract: To test the hypothesis that dopamine antagonist drugs attenuate the reinforcing properties of food, rats previously trained to traverse a straight runway for food reward subsequently underwent extinction sessions. After running speeds had substantially decreased, rats received a single food-rewarded trial either in the presence or absence of haloperidol (0, 0.15 or 0.30 mg/kg IP). Twenty-four hours later, animals were tested for reinstatement of the running response during a drug-free test trial. Animals that were nondrugged during the food-rewarded trial showed increases in running speed on the test trial relative to extinction baseline speeds. In contrast, animals under the influence of haloperidol during the food-rewarded trial failed to show test day increases in running speed. Additional control groups ruled out the possibility that the haloperidol results were due to either motor or state-dependent learning effects. The findings support the view that dopamine systems play a role in the neural substrates underlying food reinforcement. In addition, the study demonstrates a simple and effective methodology for separating neuroleptic effects on motor and reinforcement processes.
authors.affiliation: Department of Psychology, University of California, Santa Barbara 93106.
authors.forename: J C
authors.initials: JC
authors.lastname: Horvitz
authors.forename: A
authors.initials: A
authors.lastname: Ettenberg
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005502:Food; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009042:Motivation; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology; D012107:Research Design; D012201:Reward
chemical_list: D006220:Haloperidol