Blood pressure and erythrocyte Na+ transport systems in a French urban male population.
This paper reports an investigation of blood pressure (taken as a continuous variable) as a function of: erythrocyte Na+ content; Na+,K+ pump; Na+,K+ cotransport and Na+,Li+ countertransport fluxes, and passive cation permeabilities in fresh erythrocytes from 129 French males who were living in an urban area and were not under treatment for any medical condition (after allowing for the effects of age, body mass index, alcohol and tobacco consumption). In contrast with previous findings in a North American population, we were unable to confirm that blood pressure was correlated with erythrocyte Na+ content and Na+,K+-AT-Pase activity. Conversely, the only transport parameter correlated (negatively) with blood pressure was outward Na+,K+ cotransport [r = -0.20, P less than 0.05 and r = -0.19, P less than 0.05, for systolic (SAP) and diastolic arterial pressure (DAP), respectively; n = 114]. When allowing for age, body mass index and alcohol consumption, the correlation coefficient between the Na+,K+ cotransport system and blood pressure increased from -0.20 to -0.28 (P less than 0.01) for SAP and from -0.19 to -0.28 (P less than 0.01) for DAP (n = 105). We conclude that the correlations between blood pressure and erythrocyte Na+ transport function could differ between North American and French (or Mediterranean) populations. In any case, a decreased pump or outward Na+,K+ cotransport activity may lead hypertensive subjects to a similar increase in cell Na+ (and Ca2+) content in the vascular wall.
Hannaert
P A
PA
INSERM U7/CNRS UA 318, Hôpital Necker, Paris, France.
Moreau
T
T
Huel
G
G
Orssaud
G
G
Lellouch
J
J
Claude
J R
JR
Sahuquillo
J
J
Garay
R P
RP
D000328:Adult; D000367:Age Factors; D000428:Alcohol Drinking; D001692:Biological Transport; D001794:Blood Pressure; D001835:Body Weight; D004912:Erythrocytes / Q000378:metabolism*; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged; D012907:Smoking; D012964:Sodium / Q000097:blood*; D014505:Urban Population
D012964:Sodium