Comparison of 1% sodium tetradecyl sulfate to a thrombogenic sclerosant cocktail for endoscopic sclerotherapy.
This preliminary report suggests superior efficacy of a mixture of Sodium Tetradecyl Sulfate, thrombin and cefazolin (ST-Thr-Cef) over 1% Sodium Tetradecyl Sulfate (ST) in the early control of variceal bleeding. The overall management of patients treated with ST-Thr-Cef was superior as indicated by fewer hospital days and lesser transfusion requirements. Though trends were suggestive, we were unable to demonstrate a survival advantage for patients treated with ST-Thr-Cef. There was a low number of complication in both treatment groups and they were easily managed.
Lyons
S D
SD
Department of Surgery, Wayne State University, Detroit, MI 48201.
Sugawa
C
C
Geller
E R
ER
Vandenberg
D M
DM
D000328:Adult; D000368:Aged; D001803:Blood Transfusion; D002437:Cefazolin / Q000008:administration & dosage / Q000009:adverse effects; D004338:Drug Combinations; D004724:Endoscopy; D004932:Esophageal and Gastric Varices / Q000628:therapy*; D005233:Fatty Alcohols / Q000627:therapeutic use*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000628:therapy*; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012981:Sodium Tetradecyl Sulfate / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013917:Thrombin / Q000008:administration & dosage* / Q000009:adverse effects
D004338:Drug Combinations; D005233:Fatty Alcohols; D013917:Thrombin; D002437:Cefazolin; D012981:Sodium Tetradecyl Sulfate