Adverse reactions to trimethoprim-sulfamethoxazole in hemophiliacs.
Adverse reactions to trimethoprim-sulfamethoxazole are very prevalent in patients with acquired immunodeficiency syndrome (AIDS). Recently we have observed severe toxicities associated with trimethoprim-sulfamethoxazole in three hemophiliacs, a group known to be at risk for developing AIDS. At the time of these reactions to the antibiotic, none of the patients had yet manifested any stigmata of AIDS per se. We advise caution in the use of trimethoprim-sulfamethoxazole in hemophiliacs and other patients at high risk for the development of AIDS.
Nahum
K
K
Department of Medicine, University of Medicine and Dentistry of New Jersey, New Brunswick 08903-0019.
Saidi
P
P
Kim
H C
HC
Karp
G I
GI
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013420:Sulfamethoxazole / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000890:Anti-Infective Agents; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole