title: Diurnal variation in fentanyl-induced hormone responses and side effects.
abstract: The prolactin (PRL) and thyrotropin (TSH) secretory response to the opioid agonist fentanyl (0.1 mg IV) was investigated with serial blood sampling in ten healthy women at 9 AM and 9 PM on different days. In five subjects saline control trials were also performed. A repeated-measures analysis of variance yielded a highly significant effect of fentanyl administration both on PRL and TSH secretion. In every case there were elevated hormone responses in the evening, and more drug-related subjective symptoms were reported at this time than before noon. These findings indicate a diurnal variation of opioid responsiveness, with lower sensitivity in the morning.
authors.affiliation: National Institute of Nervous and Mental Diseases, Budapest, Hungary.
authors.forename: E
authors.initials: E
authors.lastname: Frecska
authors.forename: M
authors.initials: M
authors.lastname: Arato
authors.forename: C M
authors.initials: CM
authors.lastname: Banki
authors.forename: G
authors.initials: G
authors.lastname: Bagdy
authors.forename: A
authors.initials: A
authors.lastname: Perenyi
authors.forename: K
authors.initials: K
authors.lastname: Mohari
authors.forename: M I
authors.initials: MI
authors.lastname: Fekete
mesh_terms: D000328:Adult; D002940:Circadian Rhythm; D005283:Fentanyl / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D012016:Reference Values; D013972:Thyrotropin / Q000097:blood*
chemical_list: D011388:Prolactin; D013972:Thyrotropin; D005283:Fentanyl