Algae as possible sources of antitumoural agents. Preliminary evaluation of the "in vitro" cytostatic activity of crude extracts.
Aqueous, ethanolic and chloroformic extracts of 13 algae from the Gulf of Trieste (North Adriatic Sea) were assayed in vitro against human tumour established cell line (KB). Some of them exhibit a noteworthy cytostatic activity, in particular Dictyopteris membranacea (Stackh.) Batt., which significantly inhibits the growth of the cell cultures in all the three different crude extracts, was quantitatively screened in different periods of the year for the presence of cytostatic compound(s).
Kosovel
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Department of Biology, University of Trieste, Italy.
Avanzini
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Scarcia
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Furlani
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D000970:Antineoplastic Agents / Q000302:isolation & purification*; D004353:Drug Evaluation, Preclinical; D056890:Eukaryota / Q000032:analysis*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D010936:Plant Extracts