Aspects of biocompatibility of two different dialysis membranes: cuprophane and polysulfone.
Intradialytic hypoxemia, leukopenia and coagulation system activation were monitored in 9 uremic patients during hemodialysis with cuprophane (Cu) and polysulfone (Psf) membranes, using the following parameters: polymorphonuclear count (PMN), elastase alpha-1 proteinase inhibitor (EI-alpha 1PI) complex, platelet count, beta-thromboglobulin (BTG), fibronectin (FN) and arterial oxygen tension (PaO2). Our results indicate that 1) intradialytic hypoxemia observed with both membranes does not seem to be exclusively related to the well-known membrane-dependent leukopenia; 2) platelet activation, as demonstrated by the plasma BTG increase, appears to be an exclusive cellulosic membrane-related phenomenon; 3) at the same time platelet activation seems to be the major factor responsible for high FN levels, the highest FN levels occurring concurrently with the lowest platelet count.
Amato
M
M
Department of Nephrology, Careggi Hospital, Florence, Italy.
Salvadori
M
M
Bergesio
F
F
Messeri
A
A
Filimberti
E
E
Morfini
M
M
D001672:Biocompatible Materials; D001798:Blood Proteins; D002482:Cellulose / Q000031:analogs & derivatives*; D005260:Female; D005353:Fibronectins / Q000097:blood; D006098:Granulocytes / Q000201:enzymology; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000502:physiology*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011108:Polymers; D011480:Protease Inhibitors / Q000097:blood; D006435:Renal Dialysis / Q000295:instrumentation*; D013450:Sulfones; D000515:alpha 1-Antitrypsin
D001672:Biocompatible Materials; D001798:Blood Proteins; D005353:Fibronectins; D008567:Membranes, Artificial; D011108:Polymers; D011480:Protease Inhibitors; D013450:Sulfones; D000515:alpha 1-Antitrypsin; C017662:polysulfone P 1700; D002482:Cellulose; C009865:cuprammonium cellulose; D010100:Oxygen