Severe Raynaud's phenomenon in a patient with antinuclear antibody-negative systemic lupus erythematosus.
There is a well-recognized subset of patients with clinical findings consistent with systemic lupus erythematosus (SLE) but with negative antinuclear antibodies (ANA). Most of these patients have significant cutaneous involvement with little central nervous system or renal pathology. The following case report describes such a patient whose presentation was suggestive of SLE but who was ANA negative despite repeated testing. Additionally, the patient was found to have severe Raynaud's phenomenon and cutaneous vasculitis. This case is noteworthy because of the prominence of vascular insufficiency as a presenting feature of ANA-negative SLE.
Maxwell
C J
CJ
Potter
E
E
Townsend
J
J
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D011928:Raynaud Disease / Q000209:etiology*
D000974:Antibodies, Antinuclear