Neonatal screening for congenital adrenal hyperplasia using 17-hydroxyprogesterone assay in filter paper blood spots.
Screening of infants for congenital adrenal hyperplasia (CAH) using filter paper blood samples collected on the 5th day of life was performed with a radioimmunoassay for 17-hydroxyprogesterone without extraction with organic solvents. A total of 153,000 newborns were screened and 12 cases of CAH were detected (1:12,800). With recall levels related to gestational age, the recall rate could be lowered to 0.05%.
Larsson
A
A
Department of Bacteriology, National Bacteriological Laboratory, Stockholm, Sweden.
Hagenfeldt
L
L
von Döbeln
U
U
Curstedt
T
T
Gustafsson
J
J
Svensson
E
E
D019326:17-alpha-Hydroxyprogesterone; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D006908:Hydroxyprogesterones / Q000097:blood*; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D008403:Mass Screening; D010209:Paper; D011863:Radioimmunoassay; D012016:Reference Values
D015415:Biomarkers; D006908:Hydroxyprogesterones; D019326:17-alpha-Hydroxyprogesterone