title: X-ray structure determination of mexiprostil, a new gastroprotective 16-methoxy-16-methyl-PGE1 analogue.
abstract: Mexiprostil is a new gastroprotective 16-methoxy-16-methyl-PGE1 methyl ester. To assign the absolute configuration at C-15, a crystalline high-melting C-1 ester analog 5 11,15-dihydroxy-16-methoxy-16-methyl-9-oxoprost-13-en-1-oic acid 4-(4-bromobenzamide)phenyl ester (15R, 16R) was prepared and submitted to single crystal X-ray analysis. Since C-8, C-11, C-12 and C-16 are shown to have R configurations, the X-ray diffraction results established that the configuration at C-15 is also R.
authors.affiliation: Department of Diffractometry, CNR, University of Parma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pelizzi
authors.forename: R
authors.initials: R
authors.lastname: Ciabatti
authors.forename: G
authors.initials: G
authors.lastname: Padova
authors.forename: G
authors.initials: G
authors.lastname: Tarzia
mesh_terms: D000527:Alprostadil / Q000031:analogs & derivatives*; D000897:Anti-Ulcer Agents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D011459:Prostaglandins E, Synthetic; D014961:X-Ray Diffraction
chemical_list: D000897:Anti-Ulcer Agents; D011459:Prostaglandins E, Synthetic; D000527:Alprostadil; C036058:mexiprostil