Effects of systemic pancreastatin on memory retention.
Pancreastatin, a peptide isolated from the pancreas, was shown to enhance memory retention after peripheral administration in mice when administration following T-maze footshock avoidance training. The effect of pancreastatin on memory retention, one week after training, was time dependent showing enhancement of retention when pancreastatin was administered 0 and 30 min but not 60 min after training. Pancreastatin reversed the amnesia produced by scopolamine. The pancreastatin fragment (33-49) also enhanced memory. Pancreastatin did not increase glucose in vivo. We conclude that peripherally administered pancreastatin modulates memory processing.
Flood
J F
JF
Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Sepulveda, CA 91343.
Morley
J E
JE
Tatemoto
K
K
D000647:Amnesia; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D053379:Chromogranin A; D004305:Dose-Response Relationship, Drug; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D010187:Pancreatic Hormones / Q000494:pharmacology*; D012016:Reference Values; D012601:Scopolamine / Q000037:antagonists & inhibitors / Q000494:pharmacology
D001786:Blood Glucose; D053379:Chromogranin A; D010187:Pancreatic Hormones; C050836:pancreastatin; D012601:Scopolamine