Effect of propofol on cerebral blood flow and metabolism in man.
Cerebral blood flow, cerebral oxygen consumption, lactate and glucose metabolism were measured in 13 patients during anaesthesia with nitrous oxide, oxygen and enflurane 0.5% and after 30 minutes infusion of propofol. The mean blood concentration of propofol was 4.06 micrograms/ml. Cerebral blood flow decreased by 27.6% and cerebral vascular resistance by 51%. There were no changes in lactate and glucose metabolism. Cerebral oxygen consumption decreased by 18.25%. Changes in the electro-encephalograph were related to the blood levels of propofol.
Vandesteene
A
A
Department of Isotopes, Erasme Hospital, Free University of Brussels, Belgium.
Trempont
V
V
Engelman
E
E
Deloof
T
T
Focroul
M
M
Schoutens
A
A
de Rood
M
M
D000328:Adult; D000768:Anesthesia, General; D000777:Anesthetics / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D010636:Phenols / Q000494:pharmacology*; D015742:Propofol; D012039:Regional Blood Flow / Q000187:drug effects
D000777:Anesthetics; D010636:Phenols; D015742:Propofol