Influence of genetic obesity and of fat-feeding on hepatic FABP concentration and activity.
When lean and obese Zucker rats were fed a low-fat diet (6.5 percent lipid-derived energy) their hepatic fatty acid binding protein (FABP) concentrations and activities were comparable. After 18 days of fat-feeding (57 percent lipids) FABP concentration and activities were significantly increased to the same extent in both genotypes. Thus hepatic FABP levels are subject to modulation by dietary lipids but not by genetic obesity.
Malewiak
M I
MI
Laboratoire de Physiopathologie de la Nutrition, INSERM U 177, Institut Biomédical des Cordeliers, Paris, France.
Bass
N M
NM
Griglio
S
S
Ockner
R K
RK
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism*; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D008099:Liver / Q000378:metabolism*; D008297:Male; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D011924:Rats, Zucker
D002352:Carrier Proteins; D004041:Dietary Fats; C490174:Fabp7 protein, rat; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins