Effect of c-myc gene expression on early inducible reactions required for erythroid differentiation in vitro.
By employing cell fusion between two genetically marked mouse erythroleukemia (MEL) cells in which an artificially introduced c-myc gene had been placed under the control of human metallothionein promoter, we investigated the mechanism of the suppressive action of c-myc gene expression in erythroid differentiation. The results indicated that the expression of the c-myc gene blocked the induction of dimethyl sulfoxide-inducible activity, one of the two early activities required for triggering the differentiation.
Kaneko-Ishino
T
T
Institute of Applied Microbiology, University of Tokyo, Japan.
Kume
T U
TU
Sasaki
H
H
Obinata
M
M
Oishi
M
M
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002459:Cell Fusion; D002460:Cell Line; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005796:Genes; D006801:Humans; D007700:Kinetics; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics; D008668:Metallothionein / Q000235:genetics; D051379:Mice; D011401:Promoter Regions, Genetic; D011519:Proto-Oncogenes; D014158:Transcription, Genetic
D008668:Metallothionein; D004121:Dimethyl Sulfoxide