Distribution of Lyt antigens on the surface of thymocytes associated with thymic macrophages and dendritic cells.
Thymocyte subpopulations that are associated with macrophages and dendritic cells of the thymus in vivo were isolated from the thymuses of C57B1/6 mice, and their Lyt phenotypes were analyzed. Electron-microscopic examination of immunogold-labeled cells revealed that the thymic complexes formed by macrophages mainly contained Lyt-2-positive thymocytes, while Lyt-1-positive thymocytes were more frequently associated with dendritic cells. The characteristic distributions of Lyt antigens on the surface of thymocytes in regions of reciprocal contact with macrophages (Lyt-2-positive cells) and dendritic cells (Lyt-1-positive cells) suggest that these antigens play a role in specific interactions between thymocytes and stroma cells.
Brelińska
R
R
Department of Histology and Embryology, Medical Academy, Poznań, Poland.
Warchoł
J B
JB
Boniver
J
J
Houben-Defresne
M P
MP
D000818:Animals; D000950:Antigens, Ly; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D006046:Gold; D007150:Immunohistochemistry; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
D000950:Antigens, Ly; D006046:Gold