title: The effect of N-acetylneuraminic acid on the mucociliary transport impaired by cigarette smoke.
abstract: Cigarette smoke exposure impaired the mucociliary transport on the tracheal mucosa of pigeons. N-acetylneuraminic acid (NANA), but not lactose, dose-dependently protected against the impairment of the mucociliary transport. The results suggest that NANA, a representative sialic acid existing on the airway epithelium, may participate the defence mechanism in the respiratory tract against irritant gases.
authors.affiliation: Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyata
authors.forename: N
authors.initials: N
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Yuki
authors.forename: K
authors.initials: K
authors.lastname: Takahama
authors.forename: Y
authors.initials: Y
authors.lastname: Okano
authors.forename: H
authors.initials: H
authors.lastname: Kai
mesh_terms: D000818:Animals; D010856:Columbidae; D005260:Female; D007785:Lactose / Q000494:pharmacology; D008297:Male; D009079:Mucociliary Clearance / Q000187:drug effects*; D012794:Sialic Acids / Q000494:pharmacology*; D012907:Smoking / Q000378:metabolism*; D013997:Time Factors
chemical_list: D012794:Sialic Acids; D007785:Lactose