The cell cycle time in intestinal crypts by simulation of FLM experiments.
A computer program is developed that permits simulation of the dynamic behaviour of cells in intestinal crypts (Meinzer & Sandblad, 1985). Here we present the simulation of FLM data which is compared with the experimental findings of Al-Dewachi et al. (1974). The phase durations and total cycle times of cells in the jejunal crypts of rats were calculated. Additionally, the influence of various control parameters on the simulation output is discussed, e.g. the standard errors of phase times and the grain dilution at mitosis.
Meinzer
H P
HP
German Cancer Research Center, Department Medical and Biological Informatics, Heidelberg.
Chen
W
W
Sandblad
B
B
Wright
N
N
D000818:Animals; D002453:Cell Cycle; D003198:Computer Simulation; D004847:Epithelial Cells; D004848:Epithelium / Q000648:ultrastructure; D006168:Guinea Pigs; D007399:Interphase; D007422:Intestines / Q000166:cytology* / Q000648:ultrastructure; D051379:Mice; D008871:Microvilli / Q000648:ultrastructure; D008938:Mitosis; D051381:Rats