Single photon emission computed tomography in seizure disorders.
Fourteen children with various seizure disorders were studied using a cerebral blood flow tracer, 123I iodoamphetamine (0.05 mCi/kg), and single photon emission computed tomography (SPECT). In the five patients with radiological lesions, SPECT showed congruent or more extensive abnormalities. Five of the nine children with a normal scan on computed tomography had abnormal SPECT studies consisting of focal hypoperfusion, diffuse hemispheric hypoperfusion, multifocal and bilateral hypoperfusion, or focal hyperperfusion. A focal lesion seen on SPECT has been found in children with tonic-clonic seizures suggesting secondarily generalised seizures. Moreover the pattern seen on SPECT seemed to be related to the clinical status. An extensive impairment found on SPECT was associated with a poor evolution in terms of intellectual performance and seizure frequency. Conversely all children with a normal result on SPECT had less than two seizures per year and normal neurological and intellectual development.
Denays
R
R
Department of Neurology, St Peter's Hospital, Free University of Brussels, Belgium.
Rubinstein
M
M
Ham
H
H
Piepsz
A
A
Noël
P
P
D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis / Q000000981:diagnostic imaging*; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
D000662:Amphetamines; D007457:Iodine Radioisotopes; C041336:4-iodoamphetamine