Inflammatory edema induced by carrageenin in monosodium glutamate-treated rats.
Rats treated with monosodium glutamate (MSG) during the neonatal period show hypothalamic lesions and multiple neuroendocrine alterations manifested as a remarkable increase in levels of circulating corticosterone and obesity. Paw edema induced by local injection of carrageenin was significantly reduced in MSG-treated rats compared to normal rats. In contrast, both adrenalectomized rats and adrenalectomized, MSG-treated rats showed an increased response to carrageenin relative to controls. These results suggest that glucocorticoids are important modulators of inflammation in this phase of the process.
Limãos
E A
EA
Departamento de Fisiologia, Escola Paulista de Medicina, São Paulo, Brasil.
Silveira
V L
VL
Dolnikoff
M S
MS
D000315:Adrenalectomy; D000818:Animals; D002351:Carrageenan / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced* / Q000517:prevention & control; D005260:Female; D005971:Glutamates / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012970:Sodium Glutamate / Q000494:pharmacology*
D005971:Glutamates; D002351:Carrageenan; D012970:Sodium Glutamate