[Nuclear medicine diagnosis of Alzheimer type dementia].
Eleven patients with Alzheimer type dementia were investigated by single-photon-emission computed tomography (SPECT) using 99mTc-hexamethylpropylene-aminoxim (HM-PAO). Nine had a typical, symmetrically reduced enrichment in the parieto-temporo-occipital area. In three of these nine patients a similar pattern was recorded additionally in the frontal, in the remaining two in the temporal or parietal region. In a semi-quantitative evaluation radioactivity concentrations in the cerebrum and cerebellum were compared. It demonstrated that there was in relation to the cerebellum a reduced concentration in seven of the eight studied cerebral regions. The relative blood flow of the parieto-temporo-occipital region was most markedly affected and in patients with Alzheimer type dementia was reduced by 25% below that of normal subjects. The results indicate that cerebral SPECT with HM-PAO is a reasonable method of investigation to confirm the diagnosis of "Alzheimer type dementia" and exclude other cerebral disease, especially if pathognomonic findings are to be obtained.
Grünwald
F
F
Institut für Klinische und Experimentelle Nuklearmedizin, Universität Bonn.
Broich
K
K
Hartmann
A
A
Adam
S
S
Erkwoh
R
R
Bockisch
A
A
Frede
S
S
Hotze
A
A
Reichmann
K
K
Biersack
H J
HJ
D000544:Alzheimer Disease / Q000175:diagnosis*; D001921:Brain / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D003937:Diagnosis, Differential; D006801:Humans; D008875:Middle Aged; D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime
Nuklearmedizinische Diagnostik der Demenz vom Alzheimer-Typ.