title: The effect of a staphylococcal cell wall factor on the early inflammatory response to staphylococcal infection of the lactating bovine udder.
abstract: The effect on the early inflammatory response in the bovine mammary gland of a factor extracted from the cell wall of Staphylococcus aureus was studied. The insoluble factor was extracted from a 3h-culture, and was mixed with S. aureus from an overnight culture (OF) for experimental infection of a lactating quarter. Other quarters were infected with a 3h or an overnight culture (O). Five cows were used in the experiment. The O-quarters showed more severe clinical signs than seen in the 3h-and OF-quarters. Antitrypsin levels and NAGase concentrations were much reduced in the 3h-and OF-quarters. While the cell wall factor profoundly reduced the early inflammatory response, the effect on the final outcome of the infection was not determined.
authors.affiliation: Department of Veterinary Pathology and Public Health, University of Queensland, St Lucia.
authors.forename: T
authors.initials: T
authors.lastname: Mattila
authors.forename: D
authors.initials: D
authors.lastname: O'Boyle
authors.forename: A J
authors.initials: AJ
authors.lastname: Frost
mesh_terms: D000118:Acetylglucosaminidase / Q000032:analysis; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002417:Cattle; D002473:Cell Wall; D003611:Dairy Products / Q000032:analysis; D005260:Female; D007774:Lactation; D007785:Lactose / Q000032:analysis; D008414:Mastitis, Bovine / Q000628:therapy*; D008892:Milk / Q000166:cytology; D011247:Pregnancy; D013203:Staphylococcal Infections / Q000628:therapy / Q000662:veterinary*; D013211:Staphylococcus aureus; D014361:Trypsin Inhibitors / Q000032:analysis
chemical_list: D000893:Anti-Inflammatory Agents; D014361:Trypsin Inhibitors; D000118:Acetylglucosaminidase; D007785:Lactose