Interleukin-1 is an astroglial growth factor in the developing brain.
The immunomodulator interleukin-1 (IL-1) is found to be an astroglial growth factor during development of the mammalian brain. In vitro studies indicate that ameboid microglia, a class of brain mononuclear phagocytes, are the likely source of IL-1. Examination of different brain regions during development shows IL-1 production only after the appearance of ameboid microglia. These observations suggest that brain mononuclear phagocytes secrete growth factors that regulate normal growth and development of the CNS.
Giulian
D
D
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.
Young
D G
DG
Woodward
J
J
Brown
D C
DC
Lachman
L B
LB
D000818:Animals; D001253:Astrocytes / Q000378:metabolism* / Q000502:physiology; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D007375:Interleukin-1 / Q000378:metabolism* / Q000502:physiology; D010586:Phagocytes / Q000378:metabolism; D051381:Rats
D007375:Interleukin-1