Association of HLA-DR3 with human immune response to Lol p I and Lol p II allergens in allergic subjects.
Associations between HLA type and IgE or IgG antibody (Ab) responses to two well-characterized, antigenetically non-crossreactive components of Lolium perenne (rye grass) pollen extract, Lol p I (Rye I) and Lol p II (Rye II) were studied in two groups of skin-test positive (ST+) Caucasoid adults. By both nonparametric and parametric statistical methods, significant associations were found between Ab responses to both Lol I and Lol II and the possession of HLA-DR3. In view of the well-known associations of both DR3 and B8 (which are in linkage disequilibrium) with many autoimmune diseases, differences in anti-Lol I and anti-Lol II mean log[Ab] levels between B8+, DR3- vs B8-, DR3- subjects and B8+, DR3+ vs B8-, DR3+ subjects were investigated. No differences were found. Our data, along with recent RFLP and DNA sequence studies, suggest that an Ia molecule involved in immune recognition of a similar major Ia recognition site of both the Lol molecules may consist of a DR3 alpha-beta I pair. Abbreviations used: Ab: Antibody. HLA: Human leukocyte antigen. Lol p I, Lol I: Group I allergen from Lolium perenne pollen (Rye I). Lol p II, Lol II: Group II allergen from Lolium perenne pollen (Rye II). Mr: Relative molecular mass. Rx: Immunotherapy with grass pollen extracts. ST: Skin test.
Freidhoff
L R
LR
Department of Medicine, Johns Hopkins University School of Medicine, Good Samaritan Hospital, Baltimore, Maryland.
Ehrlich-Kautzky
E
E
Meyers
D A
DA
Ansari
A A
AA
Bias
W B
WB
Marsh
D G
DG
D000485:Allergens / Q000276:immunology*; D052179:Antigens, Plant; D006681:HLA-D Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D015803:HLA-DR3 Antigen; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D008129:Lolium / Q000276:immunology*; D010940:Plant Proteins; D006109:Poaceae / Q000276:immunology*; D011058:Pollen / Q000276:immunology*; D012044:Regression Analysis
D000485:Allergens; D052179:Antigens, Plant; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D007074:Immunoglobulin G; C042814:Lol p I protein, Lolium perenne; C056754:Lol p II protein, Lolium perenne; D010940:Plant Proteins; D007073:Immunoglobulin E