title: Is high and fluctuating muscle nerve sympathetic activity in the sleep apnoea syndrome of pathogenetic importance for the development of hypertension?
abstract: Muscle nerve sympathetic activity was recorded in six patients with the sleep apnoea syndrome (SAS). Compared with age- and sex-matched control patients, an increased activity during wakefulness was found. Sleep apnoic events were associated with sequencies of progressively increasing sympathetic activity followed by a sudden reduction of activity. The high sympathetic activity associated with SAS may be important in the development of the systemic hypertension commonly seen in these patients.
authors.affiliation: Department of Clinical Pharmacology, Sahlgren's University Hospital, Gothenburg, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Hedner
authors.forename: H
authors.initials: H
authors.lastname: Ejnell
authors.forename: J
authors.initials: J
authors.lastname: Sellgren
authors.forename: T
authors.initials: T
authors.lastname: Hedner
authors.forename: G
authors.initials: G
authors.lastname: Wallin
mesh_terms: D001794:Blood Pressure; D006339:Heart Rate; D006973:Hypertension / Q000209:etiology*; D009132:Muscles / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000503:physiopathology*
chemical_list: D010100:Oxygen