Infusion of prepro-VIP derived peptides in man: effect on secretion of prolactin.
Infusion of the three human prepro-VIP derived peptides [vasoactive intestinal peptide (VIP), peptide histidine methionine (PHM) and the newly discovered peptide histidine valine (PHV-42)] at a constant nominal rate of 5 pmol/kg/min in 6 healthy volunteers for 60 min resulted in plateau plasma levels of 56,475 and 1,052 pmol/l, respectively. Although these values were above those found in the circulation under physiological conditions, only VIP caused a significant rise of prolactin (PRL) during, and postinfusion. Circulating luteinizing hormone and cortisol concentrations remained unchanged. As peptide histidine isoleucine, the porcine equivalent of PHM, has been postulated to be a potent hypophyseal portal pituitary PRL-releasing factor in the rat, we suggest that in man, VIP is more active than either PHM or PHV-42, and is likely to be a better candidate.
Yiangou
Y
Y
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Gill
J S
JS
Chrysanthou
B J
BJ
Burrin
J
J
Bloom
S R
SR
D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D010451:Peptide PHI / Q000008:administration & dosage / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood; D011498:Protein Precursors / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D014660:Vasoactive Intestinal Peptide / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*
D010446:Peptide Fragments; D010451:Peptide PHI; D011498:Protein Precursors; C053900:peptide histidine valine 42; D014660:Vasoactive Intestinal Peptide; C055594:preprovasoactive intestinal peptide; D011388:Prolactin; D007986:Luteinizing Hormone; D006854:Hydrocortisone