title: Induction of sister chromatid exchanges (SCE) in G0 lymphocytes by plutonium-238 alpha-particles.
abstract: Irradiation of human G0 lymphocytes with plutonium-238 alpha-particles and X-rays was performed to investigate the production of sister chromatid exchanges (SCE). Alpha-particles produce a significant increase in SCE and this elevation is more significant when separated lymphocytes are irradiated. X-ray irradiation did not induce any significant increase in SCE. Therefore the relative biological effectiveness (RBE) for the induction of SCE by alpha-particles in this system is undefined and effectively infinite.
authors.affiliation: Medical Research Council, Radiobiology Unit, Chilton, Didcot, U.K.
authors.forename: S Z
authors.initials: SZ
authors.lastname: Aghamohammadi
authors.forename: D T
authors.initials: DT
authors.lastname: Goodhead
authors.forename: J R
authors.initials: JR
authors.lastname: Savage
mesh_terms: D000512:Alpha Particles; D006801:Humans; D007399:Interphase; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D011005:Plutonium; D011831:Radiation Genetics; D012854:Sister Chromatid Exchange / Q000528:radiation effects*
chemical_list: D011005:Plutonium