Behavioral effects of acute p-xylene inhalation in rats: autoshaping, motor activity, and reversal learning.
p-Xylene is a ubiquitous solvent and chemical precursor used in industry, gasoline, and household products. While the population at risk for exposure is thus quite large, little is known about its neurobehavioral effects. To evaluate the possibility that p-xylene affects cognitive behavior, male Long-Evans hooded rats inhaled p-xylene at concentrations of 0 or 1600 ppm, 4 hr per day for 1 to 5 days, and were evaluated after exposure on two learning tasks and a test of motor activity. Autoshaping was carried out across 5 successive days with p-xylene exposure in the morning followed by testing in the afternoon. For this test, the retraction of a single response lever on a variable-time 35-sec schedule was followed by delivery of a food pellet. When the force required to depress the lever was low (0.10 N), response acquisition was faster in animals having inhaled 1600 ppm p-xylene than in air-exposed controls. When the force was increased to 0.20 N, however, p-xylene-exposed rats acquired the response no faster than controls. In contrast, inhaled p-xylene at 1600 ppm suppressed response rates in an automaintained reversal learning paradigm without affecting reversal rate. Studies of motor activity showed that while vertically-directed activity was unaffected by p-xylene, horizontally-directed activity was increased by about 30% for the first 15 min of each daily 25-min test.(ABSTRACT TRUNCATED AT 250 WORDS)
Bushnell
P J
PJ
Neurotoxicology Division, United States Environmental Protection Agency, Research Triangle Park, NC 27711.
D000280:Administration, Inhalation; D000818:Animals; D007858:Learning / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D012016:Reference Values; D013997:Time Factors; D014992:Xylenes / Q000008:administration & dosage / Q000633:toxicity*
D014992:Xylenes; C031286:4-xylene