title: Prostaglandin E2 and protein levels in rabbit aqueous humor following ND:YAG laser iridotomy.
abstract: Prostaglandin E2 (PGE2) and protein levels were measured in the aqueous humor of rabbits' eyes subjected to iridotomy with the neodymium:YAG laser. Following irradiation, PGE2 levels were elevated to the highest elevation of 20.0 +/- 7.7 ng/ml (mean +/- SD) at 30 minutes as compared to control levels of 0.625 +/- 0.075 ng/ml. PGE2 concentrations progressively decreased, however, after 8 hours they remained high and did not resume control levels. Protein levels in the aqueous humor of ND:YAG irradiated eyes reached peak levels at 30 minutes to 7.8 +/- 2.2 mg/ml compared to control level of 1.3 +/- 0.4 mg/ml. A progressive decrease in protein levels was observed after peak time, but they were still above control levels, at 8 hours. Our study demonstrated that ND:YAG irradiation of the iris involves an immediate increase in PGE2 aqueous levels associated with a blood aqueous barrier disruption and augmented aqueous protein levels.
authors.affiliation: Maurice and Gabriela Goldschleger Eye Research Institute, Tel-Aviv University Sackler School of Medicine, Tel-Hashomer, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Rosner
authors.forename: S
authors.initials: S
authors.lastname: Gelerstein
authors.forename: C
authors.initials: C
authors.lastname: Weissman
authors.forename: N
authors.initials: N
authors.lastname: Naveh
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000032:analysis*; D015232:Dinoprostone / Q000032:analysis*; D005260:Female; D007498:Iris / Q000528:radiation effects*; D007834:Lasers / Q000009:adverse effects*; D008297:Male; D011506:Proteins / Q000032:analysis*; D011817:Rabbits; D013997:Time Factors
chemical_list: D011506:Proteins; D015232:Dinoprostone