The effects of flosequinan and nifedipine on glucose tolerance in healthy volunteers.
The influence of flosequinan and nifedipine on glucose tolerance has been investigated in a placebo-controlled four-way crossover study in 12 healthy volunteers. There was no statistical difference between the glucose tolerance curves after placebo, a single dose of flosequinan, chronic treatment with flosequinan or nifedipine at steady state. Headache was more frequent in volunteers on flosequinan than after either nifedipine or placebo.
Lewis
H
H
Department of Pharmacology, University of Birmingham, Medical School, Edgbaston, U.K.
Kendall
M
M
Bratty
J R
JR
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000009:adverse effects / Q000494:pharmacology*; D011804:Quinolines / Q000009:adverse effects / Q000494:pharmacology*; D013997:Time Factors; D014665:Vasodilator Agents / Q000009:adverse effects / Q000494:pharmacology*
D001786:Blood Glucose; D011804:Quinolines; D014665:Vasodilator Agents; C047316:flosequinan; D009543:Nifedipine