title: Amdinocillin: interaction with other beta-lactam antibiotics for gram-negative bacteria.
abstract: Amdinocillin was studied alone and in combination with three other beta-lactam antibiotics (aztreonam, cefoperazone, and ceftriaxone) for activity against gram-negative bacilli. These antibiotic combinations failed to show synergy by the checker-board double-dilution test or by killing kinetic studies. However, amdinocillin did show additive killing action when combined with the other beta-lactam antibiotics studied. Amdinocillin failed to induce or inhibit beta-lactamase production in species of Enterobacteriaceae, but with Pseudomonas aeruginosa, beta-lactamase production was induced. It is concluded that the activity of amdinocillin alone or in combination with another beta-lactam antibiotic should not be more effective in the treatment of infections by gram-negative bacilli than just using the beta-lactam antibiotic alone at a higher dose.
authors.affiliation: Veterans Administration Medical Center, East Orange, N.J.
authors.forename: R H
authors.initials: RH
authors.lastname: Eng
authors.forename: R
authors.initials: R
authors.lastname: Liu
authors.forename: S M
authors.initials: SM
authors.lastname: Smith
authors.forename: E S
authors.initials: ES
authors.lastname: Johnson
authors.forename: C E
authors.initials: CE
authors.lastname: Cherubin
mesh_terms: D000560:Amdinocillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004357:Drug Synergism; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000201:enzymology; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000096:biosynthesis
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; D000560:Amdinocillin