Partial reversal of the iminodipropionitrile-induced hyperkinetic syndrome in rats by alpha-tocopherol (vitamin E).
Rats were treated with the neurotoxin iminodipropionitrile (IDPN), which causes an irreversible movement disorder accompanied by axonal damage similar to that seen in vitamin E deficiency. Animals that received 2 g/kg vitamin E concurrently with 100 mg/kg IDPN for 10 days demonstrated a significantly reduced severity of IDPN-induced dyskinesia (as measured by vertical head movements) compared to animals that received IDPN alone. When animals were treated with 100 mg/kg IDPN for 10 days and then given either 2 g/kg vitamin E or an equivalent volume of sesame oil for 7 days, vitamin E produced a significant reduction in the severity of IDPN-induced dyskinesia. In both experiments, locomotor activity was unchanged by vitamin E. These data suggest a possible involvement of free radical formation in the neurotoxicity of IDPN.
Lohr
J B
JB
Psychiatry Service, San Diego VA Medical Center, California 92161.
Cadet
J L
JL
Wyatt
R J
RJ
Freed
W J
WJ
D000818:Animals; D004195:Disease Models, Animal; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009570:Nitriles / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000627:therapeutic use*
D009570:Nitriles; D014810:Vitamin E; C008110:3,3'-iminodipropionitrile