The somatosensory evoked potential predicts neurologic deficits and serotonergic pathochemistry after spinal distraction injury in experimental scoliosis.
The validity of the somatosensory evoked potential as an intraoperative spinal cord monitor was evaluated in an experimental model of scoliosis in the rat and a Harrington distraction model of injury. Under these conditions, it was found that any change in latency or amplitude of the major negative wave above a certain level was a significant predictor of an adverse neurologic outcome. Changes in latency of 4% or greater and changes in amplitude of 50% or greater were unequivocal indicators of spinal cord injury. Postmortem analyses of the spinal neurotransmitter serotonin revealed that apparent false-positive results of the SEP were, in fact, true-positive results.
Salzman
S K
SK
Department of Research, Alfred I. duPont Institute, Wilmington, Delaware.
Dabney
K W
KW
Mendez
A A
AA
Beauchamp
J T
JT
Daley
J C
JC
Freeman
G M
GM
Fonseca
A
A
Ingersoll
E B
EB
Beckman
A L
AL
Bunnell
W P
WP
D000818:Animals; D004195:Disease Models, Animal; D005073:Evoked Potentials, Somatosensory; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time; D012600:Scoliosis / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin