title: Stimulation of B-cell progenitors by cloned murine interleukin-7.
abstract: The events involved in the commitment and development of lymphoid lineage cells are poorly understood. We have used a recently described long-term culture system to establish a bioassay that can detect a novel growth factor capable of stimulating the proliferation of lymphoid progenitors. Using direct expression in mammalian cells we have isolated a complementary DNA clone encoding this novel haematopoietic growth factor, designated interleukin-7.
authors.affiliation: Immunex Corporation, Seattle, Washington 98101.
authors.forename: A E
authors.initials: AE
authors.lastname: Namen
authors.forename: S
authors.initials: S
authors.lastname: Lupton
authors.forename: K
authors.initials: K
authors.lastname: Hjerrild
authors.forename: J
authors.initials: J
authors.lastname: Wignall
authors.forename: D Y
authors.initials: DY
authors.lastname: Mochizuki
authors.forename: A
authors.initials: A
authors.lastname: Schmierer
authors.forename: B
authors.initials: B
authors.lastname: Mosley
authors.forename: C J
authors.initials: CJ
authors.lastname: March
authors.forename: D
authors.initials: D
authors.lastname: Urdal
authors.forename: S
authors.initials: S
authors.lastname: Gillis
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D001483:Base Sequence; D002454:Cell Differentiation / Q000187:drug effects*; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D015851:Interleukin-7; D007378:Interleukins / Q000235:genetics / Q000494:pharmacology*; D051379:Mice; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D015851:Interleukin-7; D007378:Interleukins; D012333:RNA, Messenger; D004247:DNA