99mTc-nitrido radiopharmaceuticals based on nitrogen heterocyclic ligands containing a thiol group.
The chromatographic and in vivo behaviour in mice of the 99mTcN- and 99mTc(Sn)-complexes of 2-mercaptopyridine, 2-mercaptopyrimidine, thiouracil, 6-mercaptopurine and thioguanine is compared. The biological distribution of the 99mTcN-complexes is generally different to that of the 99mTc(Sn)-complexes of the same ligand with the difference being very dependent on the structure of the ligand. The 99mTcN-mercaptopyrimidine complex has potential as a blood-cell labelling agent.
Baldas
J
J
Australian Radiation Laboratory, Yallambie.
Bonnyman
J
J
D000818:Animals; D006147:Guanine / Q000493:pharmacokinetics; D007553:Isotope Labeling; D051379:Mice; D011687:Purines / Q000493:pharmacokinetics; D011725:Pyridines / Q000493:pharmacokinetics; D013667:Technetium; D014001:Tin / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014498:Uracil / Q000031:analogs & derivatives / Q000493:pharmacokinetics
D011687:Purines; D011725:Pyridines; D014498:Uracil; D006147:Guanine; D013667:Technetium; D014001:Tin