Multidisciplinary approach to the therapy of chronic sinusitis.
Twenty patients with maxillary sinusitis were treated with cefotetan (1 g, i.m.) twice a day. Samples of blood and maxillary sinus mucous membrane were taken in eight patients 2 h after dosing during the third day of therapy to evaluate drug concentration. Results show the excellent clinical and bacteriological effectiveness of cefotetan, as well as its high tissue penetration.
Bassetti
D
D
Faculty of Medicine and Surgery, University of Verona, Italy.
Concia
E
E
Solbiati
M
M
Sampietro
M
M
D000328:Adult; D000368:Aged; D015313:Cefotetan / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000032:analysis; D008875:Middle Aged; D009092:Mucous Membrane / Q000032:analysis; D012852:Sinusitis / Q000188:drug therapy*; D014018:Tissue Distribution
D015313:Cefotetan