title: A study of the hypouricaemic effect of tiaprofenic acid.
abstract: Tiaprofenic acid is a non-steroidal anti-inflammatory drug which also has hypouriceamic effect. Studies involving 10 healthy volunteers were designed to investigate the mode of this effect. We postulate that the site of action of tiaprofenic acid is at the cell membrane, the mechanism being an interference with the transport of uric acid from intra- to extra-cellular fluid thus limiting its passage into the plasma. The same mechanism acting on renal tubular cells impedes reabsorption thereby increasing uric acid clearance.
authors.affiliation: Department of Biochemistry, Royal Sussex County Hospital, Brighton, UK.
authors.forename: V
authors.initials: V
authors.lastname: Lyfar
authors.forename: L
authors.initials: L
authors.lastname: Fernandes
authors.forename: E
authors.initials: E
authors.lastname: Thornton
authors.forename: J G
authors.initials: JG
authors.lastname: Cook
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001665:Binding Sites; D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D006801:Humans; D007684:Kidney Tubules / Q000187:drug effects; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D011422:Propionates / Q000494:pharmacology*; D014527:Uric Acid / Q000378:metabolism* / Q000493:pharmacokinetics
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; C021270:tiaprofenic acid; D014527:Uric Acid