title: Single photon emission computed tomography in seizure disorders.
abstract: Fourteen children with various seizure disorders were studied using a cerebral blood flow tracer, 123I iodoamphetamine (0.05 mCi/kg), and single photon emission computed tomography (SPECT). In the five patients with radiological lesions, SPECT showed congruent or more extensive abnormalities. Five of the nine children with a normal scan on computed tomography had abnormal SPECT studies consisting of focal hypoperfusion, diffuse hemispheric hypoperfusion, multifocal and bilateral hypoperfusion, or focal hyperperfusion. A focal lesion seen on SPECT has been found in children with tonic-clonic seizures suggesting secondarily generalised seizures. Moreover the pattern seen on SPECT seemed to be related to the clinical status. An extensive impairment found on SPECT was associated with a poor evolution in terms of intellectual performance and seizure frequency. Conversely all children with a normal result on SPECT had less than two seizures per year and normal neurological and intellectual development.
authors.affiliation: Department of Neurology, St Peter's Hospital, Free University of Brussels, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Denays
authors.forename: M
authors.initials: M
authors.lastname: Rubinstein
authors.forename: H
authors.initials: H
authors.lastname: Ham
authors.forename: A
authors.initials: A
authors.lastname: Piepsz
authors.forename: P
authors.initials: P
authors.lastname: Noël
mesh_terms: D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis / Q000000981:diagnostic imaging*; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; C041336:4-iodoamphetamine