title: [Effect of hydroxymethyluracil on the course of experimental pancreatitis in the rat].
abstract: Experiments were carried out on 150 male rats weighing 200-250 g and 42 white mice weighing 18-20 g by using two models of acute pancreatitis, two models of inflammation and studying osmotic resistance of erythrocytes. In experimental pancreatitis hydroxymethyluracil (50 mg/kg) decreased the blood lipase activity. The therapeutic effect of the agent is related to its anti-inflammatory and membrane-protecting properties.
authors.forename: I G
authors.initials: IG
authors.lastname: Chikaeva
authors.forename: D N
authors.initials: DN
authors.lastname: Lazareva
authors.forename: V A
authors.initials: VA
authors.lastname: Davydova
authors.forename: S G
authors.initials: SG
authors.lastname: Bagaeva
authors.forename: T G
authors.initials: TG
authors.lastname: Tolstikova
mesh_terms: D000208:Acute Disease; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005122:Exudates and Transudates / Q000187:drug effects; D008049:Lipase / Q000097:blood; D008297:Male; D051379:Mice; D009996:Osmotic Fragility / Q000187:drug effects; D010195:Pancreatitis / Q000188:drug therapy* / Q000201:enzymology; D010432:Pentoxyl / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D014498:Uracil / Q000031:analogs & derivatives*; D000516:alpha-Amylases / Q000097:blood
chemical_list: C008055:5-hydroxymethyluracil; D014498:Uracil; D010432:Pentoxyl; D008049:Lipase; D000516:alpha-Amylases
vernacular_title: Vliianie oksimetiluratsila na techenie éksperimental'nogo pankreatita u krys.