In vitro anti-Leishmanial activity of compounds in current clinical use for unrelated diseases.
Drugs in current clinical use were tested for anti-Leishmania activity using an in vitro infected macrophage assay. Out of almost 400 compounds tested, over 100 were active. The most active compounds showed ED50 values below 1 microM concentration. It is concluded that the active compounds should receive testing in the in vivo system. In addition they will act as lead compounds for further synthetic programmes.
Neal
R A
RA
Department of Medical Protozoology, London School of Hygiene and Tropical Medicine, Winches Farm Laboratories, St. Albans, Herts, UK.
Allen
S
S
D000818:Animals; D000981:Antiprotozoal Agents; D007893:Leishmania donovani / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects / Q000469:parasitology
D000981:Antiprotozoal Agents