[Effect of hydroxymethyluracil on the course of experimental pancreatitis in the rat].
Experiments were carried out on 150 male rats weighing 200-250 g and 42 white mice weighing 18-20 g by using two models of acute pancreatitis, two models of inflammation and studying osmotic resistance of erythrocytes. In experimental pancreatitis hydroxymethyluracil (50 mg/kg) decreased the blood lipase activity. The therapeutic effect of the agent is related to its anti-inflammatory and membrane-protecting properties.
Chikaeva
I G
IG
Lazareva
D N
DN
Davydova
V A
VA
Bagaeva
S G
SG
Tolstikova
T G
TG
D000208:Acute Disease; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005122:Exudates and Transudates / Q000187:drug effects; D008049:Lipase / Q000097:blood; D008297:Male; D051379:Mice; D009996:Osmotic Fragility / Q000187:drug effects; D010195:Pancreatitis / Q000188:drug therapy* / Q000201:enzymology; D010432:Pentoxyl / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D014498:Uracil / Q000031:analogs & derivatives*; D000516:alpha-Amylases / Q000097:blood
C008055:5-hydroxymethyluracil; D014498:Uracil; D010432:Pentoxyl; D008049:Lipase; D000516:alpha-Amylases
Vliianie oksimetiluratsila na techenie éksperimental'nogo pankreatita u krys.