title: Regression of intracerebral lesions in T prolymphocytic leukaemia treated with intravenous deoxycoformycin.
abstract: A case of T-prolymphocytic leukaemia (T-PLL) presenting with deafness and confusion is reported. Computerised tomography (CT) of the head showed several well-defined, rounded, high attenuation areas in the temporal, parietal and occipital regions of the brain substance that were suggestive of metastases. Treatment with weekly intravenous deoxycoformycin produced complete resolution of the CT abnormalities together with haematological evidence of disease regression 6 weeks after treatment was started.
authors.affiliation: Department of Haematology, Hammersmith Hospital, London, U.K.
authors.forename: F
authors.initials: F
authors.lastname: Brito-Babapulle
authors.forename: D
authors.initials: D
authors.lastname: Huang
authors.forename: P
authors.initials: P
authors.lastname: Lavender
authors.forename: D
authors.initials: D
authors.lastname: Galton
authors.forename: D
authors.initials: D
authors.lastname: Catovsky
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging*; D003070:Coformycin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D007945:Leukemia, Lymphoid / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015649:Pentostatin; D012263:Ribonucleosides / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D012263:Ribonucleosides; D003070:Coformycin; D015649:Pentostatin