Influence of ion-pair-formation on the pharmacokinetic properties of drugs. Part 3: Influence of hexylsalicylic acid on the pharmacokinetics of pholedrine.
Based on previous in vitro studies it could be shown that ion-pair-formation with the lipophilic hexylsalicylic acid (1) influences the pharmacokinetics of the hydrophilic drug pholedrine (2) which is ionized in all physiological media. After oral combination with 1 an increase of the AUC of 2 could be observed. This finding is due both to the increase of the absorption of 2 and to the decrease of the elimination of 2. After i.v. application the high biotransformation rate of 2 prevents an influence of 1.
Neubert
R
R
Sektion Pharmazie, Martin-Luther-Universität.
Albrecht
G
G
Taube
C
C
Weiss
M
M
Fürst
W
W
D000284:Administration, Oral; D000818:Animals; D007275:Injections, Intravenous; D008694:Methamphetamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D011817:Rabbits; D012459:Salicylates / Q000494:pharmacology*; D013566:Sympathomimetics / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D012459:Salicylates; D013566:Sympathomimetics; C059285:3-hexylsalicylic acid; D008694:Methamphetamine; C005877:pholedrine