[Pharmacological interactions between dependence-liable drugs].
Pharmacological interactions between morphine (Mor; analgesia), pentobarbital (Pent; hypnosis), ethanol (EtOH; rotarod adaptability), amphetamine (AMP; ambulation), and cocaine (Coca; ambulation) were examined in mice after a single or repeated administrations. Pretreatment with each drug, even a single dose, resulted in a modification of the effect of succeeding drugs. After 6-day daily treatment with drugs, tolerance developed to Mor, Pent, and EtOH, while reverse tolerance was developed to AMP and Coca. Development of tolerance to Pent was accelerated in the animals that were chronically treated with other drugs. Cross reverse-tolerance was obtained between AMP and Coca, on the other hand, one-way cross tolerance was observed between Mor and EtOH. A marked change was observed in the effect of each drug when administered at the peak time of withdrawal signs of Mor, barbital (Barb), and EtOH. The development of physical dependence on Mor, Barb, and EtOH was not modified by the pretreatment with other drugs. These results may serve to predict the risk of the interactions between various dependence-liable drugs in humans.
Kaneto
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Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University, Japan.
Hori
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A
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004347:Drug Interactions; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology*; D012306:Risk; D019966:Substance-Related Disorders
D000431:Ethanol; D009020:Morphine; D000661:Amphetamine; D010424:Pentobarbital; D003042:Cocaine