Solitary retinovitreal abscess as the initial manifestation of cryptococcosis.
In a 63-year-old white man with a history of long-term use of systemic corticosteroids for polyarteritis nodosa, progressive clouding of vision in the right eye developed over a 2-month period. Cytologic analysis of a fine-needle aspiration biopsy of a solitary fluffy retinovitreal mass demonstrated Cryptococcus neoformans. Subsequent cerebrospinal fluid cultures were also positive for C. neoformans. Systemic antifungal therapy was given using amphotericin-B and 5-fluorocytosine. Proliferative vitreoretinopathy developed in the right eye within 8 months. Three small yellow retinal lesions, which later resolved, developed in the fellow eye.
Hiss
P W
PW
Oncology Service, Willis Eye Hospital, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
Shields
J A
JA
Augsburger
J J
JJ
D000038:Abscess / Q000209:etiology*; D003453:Cryptococcosis; D009877:Endophthalmitis / Q000209:etiology; D005128:Eye Diseases / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000209:etiology*; D014822:Vitreous Body