Bone and mineral metabolism in adult celiac disease.
Bone mineral density (125I photon absorptiometry) was lower in 20 untreated adult celiac patients than in sex- and age-matched controls (p less than 0.001), and plasma alkaline phosphatase, parathyroid hormone, urinary hydroxyproline/creatinine levels were higher than normal (p less than 0.05, less than 0.001, less than 0.05, respectively). Gluten-free diet was started, and the patients were divided randomly into two treatment groups, one which received oral 25-hydroxyvitamin D 50 micrograms/day and one which did not. After 12 months' treatment, bone turnover markers showed a decrease, which did not reach statistical significance, and bone mineral density did not show significant modifications compared with base line in either group. It was found that a gluten-free diet followed for 1 yr can prevent further bone loss, but no significant differences were detected between the two groups.
Caraceni
M P
MP
Instituto di Scienze Mediche, Università di Milano, Italy.
Molteni
N
N
Bardella
M T
MT
Ortolani
S
S
Nogara
A
A
Bianchi
P A
PA
D015652:25-Hydroxyvitamin D 2; D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000032:analysis; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism*; D002446:Celiac Disease / Q000178:diet therapy / Q000188:drug therapy / Q000378:metabolism*; D003404:Creatinine / Q000032:analysis; D004872:Ergocalciferols / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000097:blood; D011877:Radionuclide Imaging
D004872:Ergocalciferols; D007457:Iodine Radioisotopes; D008903:Minerals; D010281:Parathyroid Hormone; D015652:25-Hydroxyvitamin D 2; D003404:Creatinine; D000469:Alkaline Phosphatase; D006909:Hydroxyproline