[Effect of marcaine and its derivative on the transmembrane potentials of the myocardial cells in the frog ventricle].
During experiments on strips of the frog ventricular myocardium and venous sinuses it was shown that marcaine and its derivative suppress the spontaneous activity of pacemaker cells, increase the threshold of occurrence of potentials of action and the minimal period of assimilation of forced excitations. These effects are dose-dependent and increase at a rise of stimulation frequency. Its derivative was inferior by effect intensity as compared with marcaine, it failed to exert a strong suppressive effect on the amplitude and duration of potentials of action.
Berdiaev
S Iu
SIu
Danilova
O E
OE
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D002045:Bupivacaine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006352:Heart Ventricles / Q000187:drug effects; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D011896:Rana temporaria; D016276:Ventricular Function
D000889:Anti-Arrhythmia Agents; D002045:Bupivacaine
Vliianie markaina i ego proizvodnogo na transmembrannye potentsialy miokardial'nykh kletok zheludochka liagushki.