title: Distribution of Lyt antigens on the surface of thymocytes associated with thymic macrophages and dendritic cells.
abstract: Thymocyte subpopulations that are associated with macrophages and dendritic cells of the thymus in vivo were isolated from the thymuses of C57B1/6 mice, and their Lyt phenotypes were analyzed. Electron-microscopic examination of immunogold-labeled cells revealed that the thymic complexes formed by macrophages mainly contained Lyt-2-positive thymocytes, while Lyt-1-positive thymocytes were more frequently associated with dendritic cells. The characteristic distributions of Lyt antigens on the surface of thymocytes in regions of reciprocal contact with macrophages (Lyt-2-positive cells) and dendritic cells (Lyt-1-positive cells) suggest that these antigens play a role in specific interactions between thymocytes and stroma cells.
authors.affiliation: Department of Histology and Embryology, Medical Academy, Poznań, Poland.
authors.forename: R
authors.initials: R
authors.lastname: Brelińska
authors.forename: J B
authors.initials: JB
authors.lastname: Warchoł
authors.forename: J
authors.initials: J
authors.lastname: Boniver
authors.forename: M P
authors.initials: MP
authors.lastname: Houben-Defresne
mesh_terms: D000818:Animals; D000950:Antigens, Ly; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D006046:Gold; D007150:Immunohistochemistry; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
chemical_list: D000950:Antigens, Ly; D006046:Gold