title: Outer membrane permeability and beta-lactamase content in Pseudomonas maltophilia clinical isolates and laboratory mutants.
abstract: Low outer-membrane permeability appears to be responsible for the generally high degree of antibiotic resistance of Pseudomonas maltophilia. Constitutive overproduction of beta-lactamases affects the sensitivity of these bacteria only to those beta-lactam antibiotics that are hydrolyzed by strain-specific beta-lactamases and that do not efficiently induce these enzymes in inducible strains.
authors.affiliation: Pharmaceuticals Division, CIBA-GEIGY Limited, Basel, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Mett
authors.forename: S
authors.initials: S
authors.lastname: Rosta
authors.forename: B
authors.initials: B
authors.lastname: Schacher
authors.forename: R
authors.initials: R
authors.lastname: Frei
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002463:Cell Membrane Permeability; D004352:Drug Resistance, Microbial; D004790:Enzyme Induction; D006868:Hydrolysis; D009154:Mutation; D011549:Pseudomonas / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000378:metabolism; D047090:beta-Lactams
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases