Validation study of gas chromatographic determination of pentachlorophenol in animal liver.
A validation study was conducted of a gas chromatographic procedure for the determination of pentachlorophenol (PCP) in chicken, pork, and beef liver. Five analysts representing 5 laboratories analyzed randomly numbered blind duplicates at 3 fortified tissue concentrations and one incurred tissue on 2 consecutive days. The PCP concentrations ranged from approximately 40 to 400 parts per billion (ppb). All data were reported to 3 significant figures in ppb. The coefficients of variation for repeatability were between 2.8 and 8.5%, except for the beef liver, at a mean value of 80 ppb PCP, where the CV was 11.3%. The CVs for reproducibility were in the range of 9.7-16.5% with little significant difference by species. The CV asymptotically approached 10% as the PCP level increased.
Gillard
D
D
Huntingdon Analytical Services, Middleport, NY 14105.
Epstein
R L
RL
Ashworth
R B
RB
Curry
K
K
Nathan
Q
Q
D000818:Animals; D002417:Cattle; D002645:Chickens; D002733:Chlorophenols / Q000032:analysis*; D002849:Chromatography, Gas; D007202:Indicators and Reagents; D008099:Liver / Q000032:analysis*; D010416:Pentachlorophenol / Q000032:analysis*
D002733:Chlorophenols; D007202:Indicators and Reagents; D010416:Pentachlorophenol