Changes in the tracheal ciliated cells in rabbits treated by cis-diamminedichloroplatinum (II) as studied by electron microscopy.
The ciliated epithelium of the rabbit's trachea was investigated after a single 5 mg dose of cis-diamminedichloroplatinum (cis-DDP). Specimens were taken for scanning electron microscopy, transmission electron microscopy and light microscopy. Examination was performed daily for 20 consecutive days. A cytotoxic effect of the drug on the ciliated epithelium was observed with bent ciliary tips, swollen tips and broken cilia. Finally the cilia were lost and large areas of the surface were covered with microvilli. However, 20 days after the drug injection, the restitution of the ciliary carpet was almost complete.
Albertsson
M
M
Department of Oncology, University Hospital, Lund, Sweden.
Hakansson
C H
CH
D000818:Animals; D002923:Cilia / Q000187:drug effects / Q000648:ultrastructure*; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009092:Mucous Membrane / Q000187:drug effects / Q000648:ultrastructure; D011817:Rabbits; D013997:Time Factors; D014132:Trachea / Q000166:cytology* / Q000187:drug effects / Q000648:ultrastructure
C034697:transplatin; D002945:Cisplatin