Structural and histochemical features of cortical thymic epithelial cells in mice with chemically-induced lymphoid leukemia.
Ultrastructural, enzyme histochemical (acide phosphatase, adenosine triphosphatase, neutral 5'-nucleotidase) and immunohistochemical (cytokeratins with monoclonal antibodies BH11 and BC3) features of the thymus cortical epithelial cells of leukemic DBA/2 inbred mice have been studied. In the leukemic mice epithelial cells appeared possessing some ultrastructural and histochemical features of cell activation. Lympho-epithelial complexes, composed mainly of BH11 and BC3 immunoreactive cells and of lymphoid cells were subcapsulary and subseptally found. It is discussed on the eventual involvement of the lympho-epithelial complexes in the intrathymic leukemogenesis during lymphoid leukemia.
Valkov
I
I
Department of Pathology, Medical Academy, Sofia, Bulgaria.
Marinova
T
T
Davidorff
M
M
Takács
L
L
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D004848:Epithelium / Q000032:analysis / Q000648:ultrastructure; D005260:Female; D007939:Leukemia L1210 / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D007945:Leukemia, Lymphoid / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008811:Mice, Inbred DBA; D013950:Thymus Gland / Q000032:analysis / Q000276:immunology / Q000473:pathology*
D014408:Biomarkers, Tumor; D008748:Methylcholanthrene