title: [A new approach in the treatment of metastatic melanoma: adoptive immunotherapy using lymphokine-activated killer cells and interleukin 2].
abstract: The treatment of metastatic malignant melanoma remains unsatisfactory. Recently, immunological approaches have been examined. In this respect, therapy with interleukin 2 (Il 2) and Lymphokine-activated killer cells (LAK-cells) is of special interest. In the present paper, the results from the literature are reviewed, and the first patient is reported, who was treated in our department with this therapeutic regimen in a phase-one study to examine the toxicity of a new Il 2 preparation.
authors.affiliation: Medizinische Klinik und Poliklinik, Universität Heidelberg.
authors.forename: U
authors.initials: U
authors.lastname: Keilholz
authors.forename: H
authors.initials: H
authors.lastname: Welters
authors.forename: R
authors.initials: R
authors.lastname: Dummer
authors.forename: W
authors.initials: W
authors.lastname: Tilgen
authors.forename: W
authors.initials: W
authors.lastname: Hunstein
mesh_terms: D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007376:Interleukin-2 / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D009362:Neoplasm Metastasis
chemical_list: D007376:Interleukin-2
vernacular_title: Ein neuer Weg in der Behandlung metastasierender Melanome: adoptive Immuntherapie mit Lymphokin-aktivierten Killerzellen und Interleukin 2.