Studies of lithium pharmacokinetics in patients with affective illness.
Lithium pharmacokinetics after a single dose and pharmacokinetic prediction of optimal lithium carbonate dose in steady-state, were investigated in 15 patients with affective illness. In nine patients the course of plasma concentration after a single dose was characteristic for two-compartment and in six patients for one-compartment model. Patients fitting the two-compartment model required higher daily lithium dose to achieve steady-state therapeutic lithium level than patients fitting the one-compartment model. A significant correlation was found between plasma lithium level 12 and 24 h after a single dose and the daily dose required for achieving optimal lithium level in the course of subsequent lithium administration.
Lehmann
W
W
Department of Psychiatry, Bydgoszcz Medical Academy, Poland.
Kanarkowski
R
R
Matkowski
K
K
Rybakowski
J
J
D000328:Adult; D005260:Female; D006801:Humans; D008094:Lithium / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D019964:Mood Disorders / Q000378:metabolism*
D008094:Lithium