title: Vascular effects of clonidine in patients with tetraplegia and unilateral brachial plexus injury.
abstract: Evidence from studies in both animals and in tetraplegics with complete cervical spinal cord transection and preganglionic lesion, indicates that clonidine lowers blood pressure predominantly by a centrally mediated action. We have investigated the haemodynamic basis of this action and performed additional studies in patients with unilateral brachial plexus injury and postganglionic lesions, to further determine the site and mechanism of its action. Blood pressure fell after clonidine in normal subjects but not in tetraplegics. In normal subjects, the fall in blood pressure was associated with a fall in cardiac output, due to a fall in both heart rate and stroke volume. Digital skin vasodilatation occurred after clonidine in normal subjects and only in the innervated limb in patients with unilateral brachial plexus injury. In tetraplegics and in the denervated limb in unilateral brachial plexus injury, there was no vasodilatation; instead a vasoconstrictor response occurred, due to the peripheral adrenoceptor action of clonidine. We conclude that the fall in blood pressure and cardiac output in normal subjects after clonidine were due to its central sympatholytic action. Digital skin vasodilatation after clonidine in normal subjects and the innervated limb in unilateral brachial plexus injury was due to the withdrawal of vasoconstrictor tone and requires intact descending sympathetic pathways.
authors.affiliation: Medical Unit, St Mary's Hospital, London, U.K.
authors.forename: J S
authors.initials: JS
authors.lastname: Kooner
authors.forename: F
authors.initials: F
authors.lastname: Stone
authors.forename: R
authors.initials: R
authors.lastname: Birch
authors.forename: H L
authors.initials: HL
authors.lastname: Frankel
authors.forename: W S
authors.initials: WS
authors.lastname: Peart
authors.forename: C J
authors.initials: CJ
authors.lastname: Mathias
mesh_terms: D000328:Adult; D001917:Brachial Plexus / Q000293:injuries*; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011782:Quadriplegia / Q000503:physiopathology*
chemical_list: D003000:Clonidine