title: Amelioration of experimental amnesia (passive avoidance failure) in rodents by the selective M1 agonist AF102B.
abstract: Effect of AF102B (cis-2-methylspiro-(1,3-oxathiolane-5,3')-quinuclidine) on experimental amnesia was examined using a passive avoidance task in rodents. The amnesia was produced by anti-cholinergic agents, AF64A (intracerebroventricularly) and scopolamine (subcutaneously). AF102B ameliorated the memory deficits in AF64A-treated rats at 0.1-1 mg/kg, i.p. and at 1-5 mg/kg p.o. and in scopolamine-treated mice at 1-10 mg/kg, i.p. These results suggest that AF102B may compensate for central cholinergic defects and could be developed as a possible therapeutic drug for senile dementia of the Alzheimer type.
authors.affiliation: Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Nakahara
authors.forename: Y
authors.initials: Y
authors.lastname: Iga
authors.forename: F
authors.initials: F
authors.lastname: Mizobe
authors.forename: G
authors.initials: G
authors.lastname: Kawanishi
mesh_terms: D000647:Amnesia / Q000139:chemically induced / Q000503:physiopathology*; D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D001388:Aziridines / Q000633:toxicity; D002794:Choline / Q000031:analogs & derivatives / Q000633:toxicity; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D010095:Oxotremorine / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology*; D011812:Quinuclidines / Q000494:pharmacology*; D012153:Retention, Psychology / Q000187:drug effects*; D012601:Scopolamine / Q000633:toxicity; D013876:Thiophenes
chemical_list: D001388:Aziridines; D010277:Parasympathomimetics; D011812:Quinuclidines; D013876:Thiophenes; D001115:Arecoline; D010095:Oxotremorine; C044894:ethylcholine aziridinium; D012601:Scopolamine; C059240:cevimeline; D002794:Choline