Naloxone fails to alter local cerebral glucose utilization in the rat.
The autoradiographic, 2-deoxy-D-[1-14C]glucose ([14C]DG) method was used to map the effects of intravenous (IV) naloxone (1.0, 10.0, and 20.0 mg/kg) on local cerebral glucose utilization (LCGU), an index of local brain function. Naloxone injected 5 min before [14C]DG did not alter LCGU in any of the fifty-six brain regions examined. Our findings suggest that acute naloxone at these doses does not significantly affect cerebral metabolism.
Fanelli
R J
RJ
Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, MD 21224.
Walovitch
R C
RC
Jasinski
D R
DR
London
E D
ED
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
D009270:Naloxone; D005947:Glucose