Genetic polymorphism of tear proteins in the rat.
Polymorphism of tear proteins was found by agarose gel electrophoresis among inbred strains of rats. The proteins (RTP-1) are inherited as a single autosomoal trait. The locus was designated Rtp-1 (rat tear protein-1) and it had two codominant alleles (Rtp-1a, Rtp-1b). Although we did not find any recombinant between the Rtp-1 and the Mup-1 loci among 67 backcross progeny, we found 3 strains with the recombinant type between them in 33 inbred strains tested. The results suggest that the Rtp-1 locus is very closely linked with the Mup-1 locus, which belongs to rat linkage group II. RTP-1 proteins strongly reacted with anti-MUP-1 A serum on agarose gel electrophoretograms.
Kondo
Y
Y
Institute of Laboratory Animals, Faculty of Medicine, Kyoto University, Japan.
Hamada
S
S
Serikawa
T
T
Yamada
J
J
D000818:Animals; D003433:Crosses, Genetic; D004587:Electrophoresis, Agar Gel; D005136:Eye Proteins / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D006824:Hybridization, Genetic; D008297:Male; D011110:Polymorphism, Genetic; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013666:Tears / Q000032:analysis*
D005136:Eye Proteins; C042434:tear proteins