title: [Removal of prednisone and prednisolone during plasma exchange].
abstract: Prednisone and prednisolone extraction was determined during seven sessions of plasma exchange in four patients. Each patient received 0.5 mg/kg of prednisone administered orally 2 hours before plasma exchange. Concentrations of prednisone and prednisolone were determined in blood before, every half hour during and at the end of plasma exchange. Both drugs were also determined in removed plasma, mean volume of removed plasma being 0.96 plasmatic mass. The amount of combined prednisone and prednisolone removed by plasma exchange was 1.70% of the administered prednisone dose. This quantity appears minimal and supplemental dosing of prednisone or modification of administration time would seem to be unnecessary.
authors.affiliation: Service de Néphrologie, Hôpital Pitié-Salpêtrière, Paris.
authors.forename: U
authors.initials: U
authors.lastname: Assogba
authors.forename: A
authors.initials: A
authors.lastname: Baumelou
authors.forename: M A
authors.initials: MA
authors.lastname: Pecquinot
authors.forename: F
authors.initials: F
authors.lastname: Raymond
authors.forename: J P
authors.initials: JP
authors.lastname: Durande
authors.forename: G
authors.initials: G
authors.lastname: Lenoir
authors.forename: J
authors.initials: J
authors.lastname: Rottembourg
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003882:Dermatomyositis / Q000097:blood / Q000188:drug therapy; D006801:Humans; D009135:Muscular Diseases / Q000097:blood / Q000188:drug therapy; D010951:Plasma Exchange; D011239:Prednisolone / Q000008:administration & dosage / Q000097:blood*; D011241:Prednisone / Q000008:administration & dosage / Q000097:blood*; D013577:Syndrome
chemical_list: D011239:Prednisolone; D011241:Prednisone
vernacular_title: Extraction de prednisone et de prednisolone au cours des échanges plasmatiques.