title: Interleukin-5 is at 5q31 and is deleted in the 5q- syndrome.
abstract: Human interleukin-5 (IL-5) is a selective eosinophilopoietic and eosinophil-activating growth hormone. By in situ hybridization this gene is mapped to chromosome 5q23.3 to 5q32. It is shown to be deleted in two patients with the 5q-syndrome and in one patient previously diagnosed with myelodysplasia whose condition had progressed to acute myeloblastic leukemia. The clustering of other genes involved in hematopoiesis (IL-3, granulocyte-macrophage colony-stimulating factor, feline sarcoma viral oncogene homolog, colony-stimulating factor 1) to the same region as IL-5 suggests a nonrandom localization and raises interesting questions concerning the evolution and regulation of these genes.
authors.affiliation: Cytogenetics Unit, Adelaide Children's Hospital, Australia.
authors.forename: G R
authors.initials: GR
authors.lastname: Sutherland
authors.forename: E
authors.initials: E
authors.lastname: Baker
authors.forename: D F
authors.initials: DF
authors.lastname: Callen
authors.forename: H D
authors.initials: HD
authors.lastname: Campbell
authors.forename: I G
authors.initials: IG
authors.lastname: Young
authors.forename: C J
authors.initials: CJ
authors.lastname: Sanderson
authors.forename: O M
authors.initials: OM
authors.lastname: Garson
authors.forename: A F
authors.initials: AF
authors.lastname: Lopez
authors.forename: M A
authors.initials: MA
authors.lastname: Vadas
mesh_terms: D000368:Aged; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D005260:Female; D006801:Humans; D015848:Interleukin-5; D007378:Interleukins / Q000235:genetics*; D008297:Male; D009693:Nucleic Acid Hybridization; D013577:Syndrome
chemical_list: D015848:Interleukin-5; D007378:Interleukins