Nontoxic concentration of antibiotics for intravitreal use--evaluated by human in-vitro ERG.
The effects of penicillin G (PC-G) sodium, procaine PC-G, cloxacillin sodium (MCIPC), disodium sulbenicillin (SBPC), cefazolin sodium (CEZ), gentamicin sulfate (GM) and fosfomycin sodium (FOM) on the electroretinogram (ERG) of the human in-vitro eye-cup were studied. The oscillatory potentials (OPs) were selectively and greatly suppressed by 1.0 mM PC-G sodium. The OPs and c-wave were suppressed by 0.85 mM procaine PC-G. The b-wave and OPs were slightly suppressed by 1.0 mM MCIPC. The a-wave, b-wave, OPs and c-wave were not deteriorated by 1.0 mM SBPC. The OPs appeared to be selectively suppressed by 1.0 mM CEZ. The b-wave was suppressed and the peak latencies of the OPs were delayed by 184 micrograms/ml (approximately 0.4 mM) GM. The amplitudes of the a-wave and c-wave were slightly enhanced and their peak latencies were slightly delayed by 184 micrograms/ml GM. The a-wave, b-wave, OPs and c-wave were not deteriorated by 1.0 mM FOM. The results of the present study on the human retina were comparable to those on the albino rabbit retina in our previous studies.
Kawasaki
K
K
Department of Ophthalmology, Kanazawa University School of Medicine, Japan.
Ohnogi
J
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002437:Cefazolin / Q000494:pharmacology; D003023:Cloxacillin / Q000494:pharmacology; D004596:Electroretinography; D005578:Fosfomycin / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D009991:Oscillometry; D010406:Penicillins / Q000494:pharmacology; D011343:Procaine / Q000494:pharmacology; D013408:Sulbenicillin / Q000494:pharmacology; D014822:Vitreous Body / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D005578:Fosfomycin; D011343:Procaine; D002437:Cefazolin; D003023:Cloxacillin; D013408:Sulbenicillin