title: Molecular interaction of non-steroidal compounds with uterine progesterone receptor (Part II).
abstract: Some possible non-steroidal antiprogestins were evaluated for their receptor binding activity by competitive protein binding assay in rabbit as well as human uterine cytosol in vitro. Of the 42 compounds belonging to 5 different series tested, dimethyl ester of monobenzylidene succinic acid, 4-ethoxycarbonyl-3-(m-methoxybenzyl)-5-(m-anisyl)-gamma-butyrolact one and 2-(3-benzyl-oxybenzyl)-3-(3-acetoxybenzyl)butane-1,4-diol exhibit around 20% inhibition of 3H-progesterone binding to uterine cytosol in both species.
authors.affiliation: Division of Endocrinology, Central Drug Research Institute, Lucknow, India.
authors.forename: A
authors.initials: A
authors.lastname: Agnihotri
authors.lastname: Neelima
authors.forename: M
authors.initials: M
authors.lastname: Seth
authors.forename: A P
authors.initials: AP
authors.lastname: Bhaduri
authors.forename: A K
authors.initials: AK
authors.lastname: Srivastava
authors.forename: V P
authors.initials: VP
authors.lastname: Kamboj
mesh_terms: D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D011374:Progesterone / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011817:Rabbits; D011980:Receptors, Progesterone / Q000187:drug effects / Q000378:metabolism*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
chemical_list: D011980:Receptors, Progesterone; D011374:Progesterone