[Modifications in the urinary excretion of gamma-carboxyglutamic acid induced by vitamin K].
To evaluate urinary GLA excretion, a marker of vitamin K metabolism, the effect of an oral calcium load was studied in 8 volunteers under three conditions: (1) after 1.5 g elementary calcium (calcium carbonate), (2) after 1.5 g calcium (Ossopan, a preparation containing 1 mg osteocalcin per g) and (3) after 1.5 g calcium but with pretreatment of 10 mg vitamin K1 orally for 3 days. No differences in blood calcium, osteocalcin concentration of calciuria were observed. However, GLA excretion was significantly higher with Ossopan or after pretreatment with vitamin K1.
Werlen
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D
Service de médecine, Hôpital de la Providence, Neuchâtel.
Robert
D
D
Leclerq
M
M
Guelpa
G
G
Pfister
C E
CE
D015055:1-Carboxyglutamic Acid / Q000652:urine*; D000328:Adult; D002118:Calcium / Q000494:pharmacology*; D002119:Calcium Carbonate / Q000494:pharmacology; D002135:Calcium-Binding Proteins / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D015675:Osteocalcin; D014812:Vitamin K / Q000494:pharmacology*
D002135:Calcium-Binding Proteins; D015675:Osteocalcin; D014812:Vitamin K; D015055:1-Carboxyglutamic Acid; D002119:Calcium Carbonate; D002118:Calcium
Modifications de l'excrétion urinaire de GLA (acide gamma-carboxyglutamique) induite par la vitamine K.