title: Massive focal brain swelling as a feature of MELAS.
abstract: Two patients are reported with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes in whom CT documented massive focal brain swelling with midline shift concurrent with exacerbations of their conditions. Brain swelling producing mass effect should be recognized as a feature of MELAS.
authors.affiliation: Department of Pediatric Subspecialties, Park Nicollet Medical Center, Minneapolis, MN 55404.
authors.forename: G N
authors.initials: GN
authors.lastname: Breningstall
authors.forename: L A
authors.initials: LA
authors.lastname: Lockman
mesh_terms: D000140:Acidosis, Lactic / Q000473:pathology*; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D001929:Brain Edema / Q000000981:diagnostic imaging / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008931:Mitochondria, Muscle / Q000473:pathology*; D009135:Muscular Diseases / Q000473:pathology*; D013577:Syndrome; D014057:Tomography, X-Ray Computed