Further evidence for the existence of an "organismic" set point in rats with dorsomedial hypothalamic nucleus lesions (DMNL rats): normal catch-up growth.
The present study was performed to assess the capacity of rats with dorsomedial hypothalamic nucleus lesions (DMNL rats) and sham-operated controls (CON) for catch-up growth following body weight (b.wt.) reduction prior to DMNL (and sham-lesion) production. Male SD rats (45 days, 157 +/- 1.3 g) were maintained for 11 days ad lib (ADLIB) after arrival and then divided into two groups. One group continued to feed ADLIB, the other group was fed half of the ration eaten by ADLIB rats for 32 days. At this point each group was divided into two subgroups. One subgroup received DMNL, the other subgroup consisted of CON. From then on all rats were fed ADLIB [except for one group of CON that was pair-fed to the ADLIB DMNL rats (PF-CON)] for 37 days (69th day of experiment) and then killed. DMNL rats lesioned at normal b.wt. (ADLIB DMNL) showed a precipitous drop in food intake, b.wt. and efficiency of food utilization (EFU). In striking contrast, rats that had received DMNL after b.wt. restriction (REST DMNL) and were then refed ADLIB showed a dramatic rise in food intake, b.wt., change in b.wt. and EFU, the latter being almost twice that of the ADLIB DMNL. Notably, the PF-CON weighed less than the ADLIB CON and utilized food poorer than ADLIB CON, REST CON and ADLIB DMNL. Liver weight (both absolute and relative (per kg 3/4 b.wt.) was reduced in DMNL irrespective of dietary treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
Bernardis
L L
LL
Neurovisceral Laboratory, VA Medical Center, Buffalo, NY 14215.
Bellinger
L L
LL
McEwen
G
G
Kodis
M
M
Feldman
M J
MJ
D000818:Animals; D001823:Body Composition; D001835:Body Weight; D001931:Brain Mapping; D004302:Dorsomedial Hypothalamic Nucleus / Q000502:physiology*; D004435:Eating; D004734:Energy Metabolism; D005508:Food Deprivation / Q000502:physiology; D007033:Hypothalamus, Middle / Q000502:physiology*; D008099:Liver / Q000254:growth & development; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains