[The significance of screening studies for the early detection of metastases in curatively operated breast carcinoma].
A retrospective analysis of 80 women with breast cancer operated on with curative intent showed that metastases developed within 8 years. The value of laboratory tests and radiological surveys for the early detection of metastases is considered. In fewer than 50% of the patients was the finding of a single abnormal laboratory result associated with tumor recurrence. However, when several findings were abnormal concomitantly this suggested tumor dissemination in about 90% of women. In 80% of the patients clinical symptoms were present at the time of tumor recurrence. In only 20% of the patients were metastases clinically silent. Since metastatic breast cancer cannot be cured by present treatment modalities, the relevance of detecting early recurrence is limited.
Fenner
D
D
Abteilung für Onkologie, Universitätsspital, Zürich.
Hofmann
V
V
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D001943:Breast Neoplasms / Q000473:pathology*; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors
D014408:Biomarkers, Tumor
Die Bedeutung von Screening-Untersuchungen zur Früherfassung von Metastasen beim kurativ operierten Mammakarzinom.