[Effects of sera of gynecological cancer and pregnancy on cellular immunity].
The effects of sera from untreated gynecological cancer patients in 1st, 2nd, 3rd trimesters of normal pregnancy on PHA and MLR induced lymphocytes blastformation, natural killer cell activity and killer T cell induction were analysed. 1. The 3H-thymidine uptake of lymphocytes by PHA and MLR significantly decreased in cancerous and 3rd trimester pregnant sera. It is thought that the existence of non specific immunosuppressive factors in these conditions, and this phenomenon might be caused by coating and/or masking of the surface of the effector cell. The factors might have an effect on the proliferation phase of lymphocyte blastoformation. 2. Normal human lymphocytes pretreated with cancerous sera inhibited natural killer cell activity. This phenomenon could not be demonstrated with pregnant sera. 3. Cancerous and 3rd trimester pregnant sera suppressed the process of killer T cell induction caused by alloantigen.
Taguchi
K
K
Department of Obstetrics and Gynecology, Akita University School of Medicine.
D003602:Cytotoxicity, Immunologic; D005260:Female; D005833:Genital Neoplasms, Female / Q000097:blood / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D011247:Pregnancy / Q000097:blood / Q000276:immunology*