Studies on metabolic pathways of cyanate in rats.
Metabolic pathways of cyanate in rats were studied by means of measurements of cyanate, carbamyl phosphate and S-carbamyl group. Approximately 30-50% of cyanate administered to rats (0.5 mmol/kg body weight) was found in buffered gastric contents, and was also detected as ammonia liberated by acid hydrolysis. However, the gastric excretion of cyanate was a temporary phenomenon just after cyanate administration. Biliary and urinary excretion of cyanate and acid-soluble S-carbamyl group are minor metabolic pathways.
Koshiishi
I
I
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Shibayama
R
R
Morimoto
Y
Y
Imanari
T
T
D000818:Animals; D001646:Bile / Q000032:analysis; D002221:Carbamyl Phosphate / Q000493:pharmacokinetics / Q000652:urine; D003485:Cyanates / Q000493:pharmacokinetics* / Q000652:urine; D005753:Gastric Mucosa / Q000378:metabolism; D006868:Hydrolysis; D008099:Liver / Q000378:metabolism; D051381:Rats
D003485:Cyanates; D002221:Carbamyl Phosphate