Modulation of sheep erythrocyte receptor expression by anti-CD4, anti-CD8, and anti-HLA antibodies.
The modulation of E receptors on T cells by anti-CD4 and/or anti-CD8 is reported. The percentage of E rosette-forming cells (RFC) was decreased when sheep erythrocyte and mononuclear cells were incubated in the presence of monoclonal antibodies anti-CD4 and/or anti-CD8. This inhibition was not due to shedding of the E receptor and it was reversed by 8-Br.-3',5' cyclic guanosine monophosphate (cGMP). In contrast, anti-HLA antibodies induced an enhancement of sheep erythrocyte receptor expression evaluated by RFC.
Nogueira-Machado
J A
JA
Departamento de Bioquímica-Imunologia, UFMG, Belo Horizonte, Brazil.
Chaves
M M
MM
Silva-Teixeira
D N
DN
D000906:Antibodies / Q000502:physiology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D012397:Rosette Formation
D000906:Antibodies; D000945:Antigens, Differentiation, T-Lymphocyte; D006680:HLA Antigens; D011948:Receptors, Antigen, T-Cell