title: [Etiopathogenic study of spontaneous perforation of the biliary tract].
abstract: Spontaneous perforation of extrahepatic bile duct is a rare entity, but is the second cause of surgical jaundice in the newborn period after biliary atresia. We review the etiological theories and three patients with this anomaly. Centrolobulillar cholestasis was present in all cases. Parietal ischemic necrosis was seen in one case, obstructive lesions (extrahepatic biliary atresia) in two and malformative lesions (choledochal cyst) in the last patient. A developmental error and a small circumscribed area of duct wall weakness have been the most accepted factors involved in its pathogenesis. However we have found histologic and morphologic evidence that ratify the obstructive and vascular lesions as relevant elements in the etiology of the spontaneous perforation of the biliary tract.
authors.affiliation: Departamento de Cirugía Pediátrica, Hospital Infantil La Paz, Madrid.
authors.forename: J C
authors.initials: JC
authors.lastname: de Agustín Asensio
authors.forename: F
authors.initials: F
authors.lastname: Rivilla Parra
authors.forename: A
authors.initials: A
authors.lastname: Torres Nieto
authors.forename: J
authors.initials: J
authors.lastname: Díez Pardo
mesh_terms: D001649:Bile Duct Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D002758:Cholangiography; D001651:Cholestasis, Extrahepatic / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D012422:Rupture, Spontaneous / Q000209:etiology* / Q000601:surgery
vernacular_title: Estudio etiopatogénico de la perforación espontánea del árbol biliar extrahepático en el neonato. A propósito de tres casos.