[Clinical evaluation of sultamicillin fine granules in pediatric infections].
Sultamicillin fine granules (SBTPC), a mutual prodrug of sulbactam (SBT) and ampicillin (ABPC), were administered to 16 pediatric patients with bacterial infections. The efficacy rate was 93.3%. MICs (10(6) cells/ml) of SBTPC against beta-lactamase non-producing strains were not significantly different from those of ABPC, and ranged from less than or equal to 0.05 to 1.56 micrograms/ml. MICs of SBTPC, however, were 2-4 fold smaller than MICs of ABPC against beta-lactamase producing strains. Diarrhea and loose stool as side effects were observed in 4 (25%) of 16 patients, but none of them were severe. After oral administration of SBTPC (10 mg/kg), serum levels of ABPC and SBT peaked at 3.41 micrograms/ml and 2.43 micrograms/ml after 0.6 hour, and declined with half-lives of 1.79 and 1.00 hours, respectively.
Meguro
H
H
Department of Pediatrics, School of Medicine, Teikyo University.
Arimasu
O
O
Hiruma
F
F
Sugie
N
N
Nishimura
S
S
Abe
T
T
Fujii
R
R
Mashiko
J
J
Nagao
Y
Y
Okamoto
Y
Y
D000367:Age Factors; D000667:Ampicillin / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D000668:Ampicillin Resistance; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D004304:Dosage Forms; D004341:Drug Evaluation; D004359:Drug Therapy, Combination / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D013407:Sulbactam / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*
D004304:Dosage Forms; C035444:sultamicillin; D000667:Ampicillin; D013407:Sulbactam