Reactivity of macro- and microvessels of DOCA-salt hypertensive rats: role of the endothelial cell.
The responses to noradrenaline (NA) and acetylcholine (ACh) of aortae and microvessels were compared in control and DOCA-salt hypertensive rats. Macro- and microvessels from hypertensive rats showed an increased response to NA and a decreased response to ACh (an endothelium-dependent vasodilator). Unlike ACh, sodium nitroprusside (an endothelium-independent agent), was equally effective in evoking a vasodilator response from aortae and microvessels of hypertensive rats. These data suggest that the impaired response to ACh and the increased response to NA in DOCA-salt hypertension may result from an alteration of endothelial cell function.
Cordellini
S
S
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Brasil.
Nigro
D
D
Carvalho
M H
MH
Fortes
Z B
ZB
Scivoletto
R
R
D000109:Acetylcholine / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects*; D003900:Desoxycorticosterone; D004730:Endothelium, Vascular / Q000502:physiology*; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D003900:Desoxycorticosterone; D000109:Acetylcholine; D009638:Norepinephrine