Complement is not activated in ABO-haemolytic disease of the newborn.
We studied the lysis in vitro of group A red cells by IgG anti-A. IgG anti-A, which strongly lysed A red cells from adults, did not lyse A red cells from cord blood, if fresh cord serum from a child with blood group AB was used as a source of complement. In cases of haemolytic disease of the newborn due to A-O or B-O antagonism with a positive direct antiglobulin test with anti-IgG serum, the red cells did not react with anti-complement sera. Apparently, complement is also not activated in vivo in case of A-O haemolytic disease of the newborn.
Brouwers
H A
HA
Central Laboratory the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Overbeeke
M A
MA
Huiskes
E
E
Bos
M J
MJ
Ouwehand
W H
WH
Engelfriet
C P
CP
D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D003167:Complement Activation; D003298:Coombs Test; D004899:Erythroblastosis, Fetal / Q000097:blood / Q000276:immunology*; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007231:Infant, Newborn
D000017:ABO Blood-Group System; D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; C048844:anti-IgG