title: Evaluation of single-dose ciprofloxacin in the eradication of Neisseria meningitidis from nasopharyngeal carriers.
abstract: The ability of a single oral 750-mg dose of ciprofloxacin to eradicate Neisseria meningitidis from persistent nasopharyngeal carriers was prospectively evaluated in a placebo-controlled, randomized, double-blinded study. Cultures of specimens taken from all 23 ciprofloxacin-dosed subjects 1 day postdose were negative; cultures from 96% of these subjects were negative at 7 and 21 days postdose, including a specimen from a subject colonized with a minocycline-resistant strain. Of 22 placebo recipients, 20 (91%) remained culture positive. Single-dose ciprofloxacin appears efficacious for meningococcal prophylaxis.
authors.affiliation: Department of Medical Microbiology, Creighton University, Omaha, Nebraska 68178.
authors.forename: D L
authors.initials: DL
authors.lastname: Dworzack
authors.forename: C C
authors.initials: CC
authors.lastname: Sanders
authors.forename: E A
authors.initials: EA
authors.lastname: Horowitz
authors.forename: J M
authors.initials: JM
authors.lastname: Allais
authors.forename: M
authors.initials: M
authors.lastname: Sookpranee
authors.forename: W E
authors.initials: WE
authors.lastname: Sanders
authors.forename: F M
authors.initials: FM
authors.lastname: Ferraro
mesh_terms: D002353:Carrier State / Q000382:microbiology / Q000517:prevention & control*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004341:Drug Evaluation; D006801:Humans; D008585:Meningitis, Meningococcal / Q000382:microbiology / Q000517:prevention & control*; D009305:Nasopharynx / Q000187:drug effects / Q000382:microbiology*; D010919:Placebos; D011897:Random Allocation
chemical_list: D010919:Placebos; D002939:Ciprofloxacin