title: Reticuloendothelial clearance and splenic mononuclear cell populations after resection and autotransplantation.
abstract: Although the preservation of splenic tissue may prevent overwhelming infection after splenectomy, the degree of protection conferred by small remnants has not been optimal. We investigated whether either splenic reticuloendothelial clearance of a blood flow-dependent colloid or macrophage and T-cell populations might be altered by resection or autotransplantation of the spleen. Our results have shown that bloodstream reticuloendothelial clearance of technetium 99m sulfur colloid is not impaired by splenectomy, partial resection of the spleen, or splenic autotransplantation. Such clearance is dependent on spleen weight and is not related to differences in either macrophage or helper or suppressor T-cell populations. This suggests that autotransplantation of the spleen is inferior to preservation of even a small hilar remnant and implies that repair or partial resection of the spleen will provide greater protection than autotransplantation.
authors.affiliation: Department of Surgery, University of Louisville School of Medicine, Kentucky 40292.
authors.forename: M A
authors.initials: MA
authors.lastname: Malangoni
authors.forename: B M
authors.initials: BM
authors.lastname: Evers
authors.forename: J C
authors.initials: JC
authors.lastname: Peyton
authors.forename: S R
authors.initials: SR
authors.lastname: Wellhausen
mesh_terms: D000818:Animals; D005260:Female; D008264:Macrophages / Q000502:physiology*; D012157:Mononuclear Phagocyte System / Q000502:physiology*; D009929:Organ Size; D010587:Phagocytosis; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000502:physiology / Q000637:transplantation*; D013156:Splenectomy; D013601:T-Lymphocytes / Q000502:physiology*; D013671:Technetium Tc 99m Sulfur Colloid; D014182:Transplantation, Autologous
chemical_list: D013671:Technetium Tc 99m Sulfur Colloid