title: Epidural vs general anaesthesia and leg blood flow in patients with occlusive atherosclerotic disease.
abstract: Total leg blood flow (plethysmography), skin blood flow (laser-Doppler flowmetry), and haemodynamic stability (MAP, HR, RPP) were studied in vascular (ABI less than 1.0; n = 31) and in non-vascular (ABI greater than 1.0; n = 24) surgical patients during epidural or fentanyl-supplemented general anaesthesia. During epidural anaesthesia significant increases in total leg blood flow were observed in vascular (from 1.9 +/- 0.2 to about 3 ml/100 ml tissue/min) as well as in non-vascular (from 2.5 +/- 0.6 to about 7 ml/100 ml tissue/min) patients and leg blood flow remained high in the postanaesthetic period. During general anaesthesia total leg blood did not increase, either in vascular or in non-vascular patients, and in the postanaesthetic period blood flow values even lower than the initial ones were observed. Skin blood flow increased about 4-fold in vascular as well as in non-vascular patients following both types of anaesthesia. In the immediate postanaesthetic period low flow values were again observed but only in the general anaesthesia groups. In vascular patients no critical redistribution of blood flow within the limb was observed irrespective of the type of anaesthesia. Good haemodynamic stability could only be maintained in the epidural group. It is concluded that epidural anaesthesia seems to offer considerable advantages over general anaesthesia for high-risk vascular patients during arterial reconstructions since better haemodynamic stability and higher leg blood flow can be achieved.
authors.affiliation: Department of Anaesthesia, University of Gothenburg, Sahlgren's Hospital, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Haljamäe
authors.forename: I
authors.initials: I
authors.lastname: Frid
authors.forename: J
authors.initials: J
authors.lastname: Holm
authors.forename: G
authors.initials: G
authors.lastname: Akerström
mesh_terms: D000368:Aged; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D001161:Arteriosclerosis / Q000503:physiopathology / Q000601:surgery*; D001783:Blood Flow Velocity / Q000187:drug effects; D005260:Female; D005283:Fentanyl / Q000494:pharmacology; D006439:Hemodynamics; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation
chemical_list: D005283:Fentanyl