[Compensatory-adaptive restructuring of the aging human brain].
In semithin sections of the frontal and temporal cortex from the human brains the compensatory-adaptive changes of neurons and glia were studied. The specimens were obtained from 2 physiologically aged subjects, 7 cases of senile dementia, 2 cases of Alzheimer disease. Alongside with the destructive changes in nerve and glial cells, the compensatory-adaptive processes were detected in aging brains, generally characteristic of the physiologic aging: the nucleolus shift to the nucleus periphery; redistribution of the nuclear chromatin, nuclear membrane invagination; closer attraction of the organelles to nuclear membrane as destruction increased; assembling the neural and glial cells; establishment of the desmosome-like glioglial contacts.
Verbitskaia
L B
LB
Semenchenko
I I
II
D000222:Adaptation, Physiological; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology* / Q000648:ultrastructure; D003704:Dementia / Q000503:physiopathology; D006801:Humans; D007365:Intercellular Junctions / Q000502:physiology / Q000648:ultrastructure; D009457:Neuroglia / Q000502:physiology / Q000648:ultrastructure; D009474:Neurons / Q000502:physiology / Q000648:ultrastructure
Kompensatorno-prisposobitel'nye perestroĭki stareiushchego mozga cheloveka.