High-dose lorazepam therapy for status epilepticus in a pediatric patient.
This report details the management of status epilepticus with high-dose lorazepam in a 14-year-old patient who was receiving oral clonazepam, ethosuximide, and phenobarbital for an intractable seizure disorder. Although respiratory depression is a frequently cited potential complication of therapy, it did not occur in this patient despite an extraordinarily high total dose of lorazepam, possibly because of tolerance associated with benzodiazepine-receptor down-regulation in this patient's chronic clonazepam therapy. Aggressive dosing of a benzodiazepine may be required for patients receiving chronic benzodiazepine therapy.
Reincke
H M
HM
Department of Neurology, College of Medicine, University of Kentucky Medical Center, Lexington 40536.
Gilmore
R L
RL
Kuhn
R J
RJ
D000293:Adolescent; D006801:Humans; D008140:Lorazepam / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D013226:Status Epilepticus / Q000188:drug therapy* / Q000503:physiopathology
D008140:Lorazepam