The antiinflammatory and immunosuppressive activity of HEPIDA-Ca and HEPIDA-Zn complex compounds.
The authors investigated the immunological and pharmacological activity of N-/2, 4-dimethylacetanilido/iminodiacetic complex compounds with calcium and zinc (HEPIDA-Ca and HEPIDA-Zn). An antiinflammatory, therapeutic effect of these compounds and also an immunosuppressive action were observed. Both complex compounds inhibited the GvH reaction in rats and attenuated the transplantation barrier.
Samochocka
K
K
Department of Chemistry, University of Warsaw.
Ryzewski
J
J
Kossakowska
M
M
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001168:Arthritis / Q000188:drug therapy*; D002118:Calcium / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy*; D005260:Female; D006087:Graft vs Host Reaction / Q000187:drug effects*; D007098:Imino Acids / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use*; D009942:Organometallic Compounds / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007098:Imino Acids; D009942:Organometallic Compounds; C059839:calcium lidofenin; C059840:zinc lidofenin; D015032:Zinc; D002118:Calcium; C008109:iminodiacetic acid