title: [Acquired factor VII inhibitor: treatment using high-dose immunoglobulins, corticotherapy and plasma exchange].
abstract: A 62 year old man presented a diffuse hemorrhagic syndrome related to the presence of an acquired factor VII inhibitor (proconvertin). Autoantibodies were of the IgG class and no subjacent disease was detected during a 7-month follow up. Treatment with high-dose polyvalent immunoglobulins was ineffective, and the onset of an intracerebral hemorrhage required therapy by a series of plasma exchanges combined with immunosuppressive treatment. The plasma inhibitor was no longer present after the first exchange and clinical and biological remission was rapid.
authors.affiliation: Service d'Hématologie, Hôtel-Dieu, Paris.
authors.forename: A
authors.initials: A
authors.lastname: Delmer
authors.forename: G
authors.initials: G
authors.lastname: Andreu
authors.forename: M H
authors.initials: MH
authors.lastname: Horellou
authors.forename: T
authors.initials: T
authors.lastname: Lecompte
authors.forename: M
authors.initials: M
authors.lastname: Samama
authors.forename: R
authors.initials: R
authors.lastname: Zittoun
mesh_terms: D002543:Cerebral Hemorrhage / Q000188:drug therapy / Q000628:therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D005167:Factor VII / Q000037:antagonists & inhibitors*; D006470:Hemorrhage / Q000188:drug therapy / Q000628:therapy*; D006801:Humans; D007116:Immunization, Passive; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D010951:Plasma Exchange
chemical_list: D003520:Cyclophosphamide; D005167:Factor VII; D008775:Methylprednisolone
vernacular_title: Inhibiteur acquis du facteur VII: traitement par immunoglobulines à fortes doses, corticothérapie et échanges plasmatiques.