title: A comparison between propofol and ketamine for anaesthesia in the elderly. Haemodynamic effects during induction and maintenance.
abstract: The haemodynamic effects of propofol and ketamine were studied in two groups of eight randomly allocated elderly patients (mean age 85.8 years) anaesthetised for hip replacement. Group 1 patients patients received propofol 1 mg/kg by intravenous bolus for induction and 0.1 mg/kg/minute by continuous infusion for maintenance. Group 2 patients received ketamine 1.5 mg/kg by intravenous bolus as induction dose and 50 micrograms/kg/minute by continuous infusion for maintenance. All patients breathed spontaneously via a facemask at FIO2 1.0. Haemodynamic status was established before induction and at 1, 3, 5, 10 and 15 minutes after induction. Arterial pressure and cardiac output decreased slightly in group 1 but heart rate, right atrial pressure and pulmonary arterial pressure remained unchanged. Myocardial oxygen consumption showed a significant decrease of 27%. There was a significant increase in blood pressure and pulmonary capillary wedge pressure (by 97%) in group 2. Cardiac output and systemic vascular resistance remained unchanged whereas myocardial oxygen consumption showed a very significant increase of 100%.
authors.affiliation: Department of Anaesthesia, Jean Rostand Hospital, Ivry, France.
authors.forename: R
authors.initials: R
authors.lastname: Maneglia
authors.forename: M T
authors.initials: MT
authors.lastname: Cousin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006622:Hip Prosthesis; D006801:Humans; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D010636:Phenols / Q000494:pharmacology*; D015742:Propofol
chemical_list: D000777:Anesthetics; D010636:Phenols; D007649:Ketamine; D015742:Propofol