Reversed-phase ion-pair liquid chromatographic method for the determination of low concentrations of haloperidol in plasma.
A sensitive liquid chromatographic method for the determination of haloperidol in plasma is described. The efficient and simple extraction procedure, followed by reversed-phase ion-pair liquid chromatography on a 3-micron octadecylsilica column and UV absorbance detection, makes it possible to determine concentrations down to 0.5 nmol/l with acceptable precision. In a pharmacokinetic study, in which 5 mg of haloperidol were given orally, the plasma levels were followed for 48 h.
Nilsson
L B
LB
Astra Research Center, Södertälje, Sweden.
D002853:Chromatography, Liquid; D006220:Haloperidol / Q000097:blood*; D006801:Humans; D007202:Indicators and Reagents; D011619:Psychotropic Drugs / Q000097:blood; D013056:Spectrophotometry, Ultraviolet
D007202:Indicators and Reagents; D011619:Psychotropic Drugs; D006220:Haloperidol