title: Transfusion-induced specific anti-factor XI inhibitor in a patient with previously unrecognized factor XI deficiency.
abstract: This article reports the rare occurrence and investigation of a specific anti-factor XI inhibitor that arose after fresh-frozen plasma infusion into a patient with previously unrecognized Factor XI deficiency. The IgG fraction of the patient's plasma that contained anti-Factor XI antibody was isolated by chromatography on DEAE-Affigel and concentrated. It was shown to exert inhibitory effect on purified Factor XI and XIa both in the activated and nonactivated partial thromboplastin time assay.
authors.affiliation: Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors.forename: C E
authors.initials: CE
authors.lastname: Musclow
authors.forename: D
authors.initials: D
authors.lastname: Amato
authors.forename: F
authors.initials: F
authors.lastname: Ofosu
authors.forename: A L
authors.initials: AL
authors.lastname: Armstrong
authors.forename: D
authors.initials: D
authors.lastname: Abbott
mesh_terms: D000368:Aged; D001780:Blood Coagulation Tests; D005172:Factor XI / Q000037:antagonists & inhibitors*; D005173:Factor XI Deficiency / Q000097:blood* / Q000175:diagnosis; D015945:Factor XIa; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000502:physiology; D065227:Transfusion Reaction
chemical_list: D007074:Immunoglobulin G; D005172:Factor XI; D015945:Factor XIa