title: Delayed extra-adrenal epinephrine secretion after bilateral adrenalectomy in rats.
abstract: Regulated systemic extra-adrenal epinephrine secretion has been demonstrated in long-term bilaterally adrenalectomized humans. To determine whether this is demonstrable immediately after adrenalectomy and therefore presumably ongoing when the adrenal medullas are intact or if it develops over time after the adrenal medullas are removed, we measured plasma catecholamine concentrations before and serially after bilateral adrenalectomy with cortical reimplantation in rats. We found plasma epinephrine concentrations to decrease from 244 +/- 41 pg/ml to levels that were not convincingly detectable, using a single-isotope derivative assay with a detection limit of 10 pg/ml, for up to 1 wk after bilateral adrenalectomy with cortical reimplantation. Plasma epinephrine concentrations increased thereafter, becoming detectable in all animals and averaging 31 +/- 6 pg/ml 4 wk after adrenalectomy. Thus extra-adrenal epinephrine secretion appears to be a delayed response to removal of the adrenal medullas and cannot be assumed to be ongoing when the adrenal medullas are intact.
authors.affiliation: Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
authors.forename: C
authors.initials: C
authors.lastname: Ricordi
authors.forename: S D
authors.initials: SD
authors.lastname: Shah
authors.forename: P E
authors.initials: PE
authors.lastname: Lacy
authors.forename: W E
authors.initials: WE
authors.lastname: Clutter
authors.forename: P E
authors.initials: PE
authors.lastname: Cryer
mesh_terms: D000302:Adrenal Cortex / Q000502:physiology / Q000637:transplantation; D000315:Adrenalectomy; D000818:Animals; D004837:Epinephrine / Q000097:blood / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D009994:Osmolar Concentration; D051381:Rats; D011917:Rats, Inbred Lew; D012038:Regeneration; D013997:Time Factors
chemical_list: D009638:Norepinephrine; D004837:Epinephrine