title: Corticosteroid 11 beta-hydroxysteroid dehydrogenase activities in vertebrate liver.
abstract: In this paper, we examine corticosteroid 11 beta-oxidation and 11-reduction as properties of the microsomal 11 beta-hydroxysteroid dehydrogenase complex in vertebrate livers. No hepatic activity in the oxidative direction (11 beta -dehydrogenase) was found in the frog, toad, mud puppy, shark, and bird livers. In contrast, all mammalian livers had active oxidizing enzymes. Latency, defined as microsome-linked activity released by the detergent Triton DF-18, was a property of 11 beta-dehydrogenase in all mammalian livers. Mammal, bird, and dogfish livers reduced 11-dehydrocorticosteroids (11-reductase), while amphibians and bony fish did not. With the exception of rat liver, latency was a property of all the mammalian liver 11-reductases examined.
authors.affiliation: Population Council, New York, NY 10021.
authors.forename: C
authors.initials: C
authors.lastname: Monder
authors.forename: V
authors.initials: V
authors.lastname: Lakshmi
mesh_terms: D042842:11-beta-Hydroxysteroid Dehydrogenases; D000818:Animals; D005075:Biological Evolution; D042944:Cholestenone 5 alpha-Reductase; D003348:Cortisone / Q000378:metabolism; D006854:Hydrocortisone / Q000378:metabolism; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D013045:Species Specificity; D013379:Substrate Specificity; D014714:Vertebrates / Q000378:metabolism*
chemical_list: D010088:Oxidoreductases; D006913:Hydroxysteroid Dehydrogenases; D042842:11-beta-Hydroxysteroid Dehydrogenases; D042944:Cholestenone 5 alpha-Reductase; D003348:Cortisone; D006854:Hydrocortisone