Effects of dietary palm oil on arterial thrombosis, platelet responses and platelet membrane fluidity in rats.
Wistar rats were fed a control diet containing 5 energy % (en %) sunflowerseed oil or diets containing 50 en % of either palm oil, rich in saturated fatty acids, or sunflowerseed oil, high in linoleic acid, for at least eight weeks. Arterial thrombosis tendency, measured by the aorta loop technique, tended to be lowered by the palm oil diet and was lowered significantly by the sunflowerseed oil diet, compared with the control. Aggregation of platelets in whole blood activated with collagen was not altered by palm oil feeding, but was enhanced in the sunflowerseed oil group, compared with the control. The concomitant formation of thromboxane A2 was decreased by palm oil feeding, although formation of prostacyclin did not change; the ratio of thromboxane/prostacyclin formed was decreased significantly in the palm oil group. Compared with the control diet, platelet membrane fluidity, measured by fluorescence polarization, was not altered in the palm oil group and was significantly increased only by sunflowerseed-oil feeding. Thus, although palm oil contains about 50% saturated fatty acids, it did not increase arterial thrombosis tendency and tended to decrease platelet aggregation, as compared with highly polyunsaturated sunflowerseed oil.
Rand
M L
ML
Department of Biochemistry, State University of Limburg, Maastricht, The Netherlands.
Hennissen
A A
AA
Hornstra
G
G
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects; D000073878:Palm Oil; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D000074242:Sunflower Oil; D013927:Thrombosis / Q000517:prevention & control*; D013928:Thromboxane A2 / Q000097:blood
D004042:Dietary Fats, Unsaturated; D010938:Plant Oils; D000074242:Sunflower Oil; D013928:Thromboxane A2; D000073878:Palm Oil