title: The biological activity and immunotherapeutic properties of AS-101, a synthetic organotellurium compound.
abstract: AS-101 (ammonium trichloro[dioxoethylene-O,O'-]tellurate) is a newly developed synthetic compound with immunomodulating properties and minimal toxicity. We evaluated the effects of AS-101 on various parameters of the activation and function of immunocompetent cells. AS-101 induced IL-2 receptor expression, IL-2 production and proliferation by human and mouse lymphocytes in vitro and enhanced the production colony-stimulating factor (CSF) by mouse spleen cells. In vivo treatment of Balb/c mice with AS-101 caused a significantly increased production of IL-2 and CSF in vitro in the presence of mitogen. When administered systemically to mice, AS-101 mediated antitumor effects in vivo. These results suggest that AS-101 is an active biological response modifier, which might have potential use in the treatment of conditions such as malignancy, AIDS and some types of immune deficiency.
authors.affiliation: Department of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
authors.forename: B
authors.initials: B
authors.lastname: Sredni
authors.forename: R R
authors.initials: RR
authors.lastname: Caspi
authors.forename: S
authors.initials: S
authors.lastname: Lustig
authors.forename: A
authors.initials: A
authors.lastname: Klein
authors.forename: Y
authors.initials: Y
authors.lastname: Kalechman
authors.forename: Y
authors.initials: Y
authors.lastname: Danziger
authors.forename: M
authors.initials: M
authors.lastname: Ben Ya'akov
authors.forename: T
authors.initials: T
authors.lastname: Tamari
authors.forename: F
authors.initials: F
authors.lastname: Shalit
authors.forename: M
authors.initials: M
authors.lastname: Albeck
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D003115:Colony-Stimulating Factors / Q000096:biosynthesis; D005030:Ethylenes / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D006801:Humans; D007167:Immunotherapy; D007376:Interleukin-2 / Q000096:biosynthesis; D007928:Lethal Dose 50; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000628:therapy; D051381:Rats; D015375:Receptors, Interleukin-2 / Q000187:drug effects
chemical_list: D000276:Adjuvants, Immunologic; D003115:Colony-Stimulating Factors; D005030:Ethylenes; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; C054105:ammonium trichloro(dioxoethylene-O,O'-)tellurate