The ability of cultivated human skin fibroblasts to store vitamin A. A contribution to the cytogenesis of the Ito cells of the liver.
Cultivated skin fibroblasts were fed with retinol palmitate in a dosage of 100,000, 200,000, or 300,000 I.U. In dependence on the dosage a remarkable uptake and storage of vitamin A can be observed in vitro (27.2, 53.0 or 60.7% of the fibroblasts). Distinctly retinol palmitate storing cells have lost their typical fibroblast-like appearance and are transformed into cells which are comparable to the Ito cells of the liver from the cytomorphological point of view.
Körner
T
T
Martin Luther University Halle, Wittenberg.
Rath
F W
FW
Schmidt
H
H
D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology* / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D008099:Liver / Q000166:cytology* / Q000378:metabolism / Q000648:ultrastructure; D008854:Microscopy, Electron; D012867:Skin / Q000166:cytology* / Q000378:metabolism / Q000648:ultrastructure; D014801:Vitamin A / Q000378:metabolism*
D014801:Vitamin A