The effects of PAF antagonists on ischaemia and reperfusion arrhythmias and ischaemia-induced platelet aggregation.
These studies were performed to investigate a role of PAF in the genesis of life-threatening arrhythmias and platelet aggregation accompanying myocardial ischaemia and reperfusion. Pretreatment with the PAF antagonists SRI 63-441 (10 mgkg-1 iv) and BN 52021 (5 mgkg-1 iv) significantly reduced the number of arrhythmias during a thirty minute coronary artery occlusion period in open-chest anaesthetised greyhounds, particularly ventricular tachycardia. Both drugs also reduce the incidence of ventricular fibrillation resulting from reperfusion of the myocardium. Myocardial ischaemia in control animals resulted in a marked fall in platelet count in blood draining the ischaemic area, which was abolished by both SRI 63-441 and BN 52021. These results suggest a role for PAF in the genesis of ischaemia and reperfusion-induced arrhythmias, possibly by inducing platelet aggregation.
Wainwright
C L
CL
Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, Scotland.
Parratt
J R
JR
Bigaud
M
M
D000818:Animals; D003327:Coronary Disease / Q000503:physiopathology*; D004224:Diterpenes; D004285:Dogs; D005260:Female; D046934:Ginkgolides; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D007783:Lactones / Q000494:pharmacology*; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors* / Q000502:physiology; D010974:Platelet Aggregation / Q000187:drug effects*; D011806:Quinolinium Compounds / Q000494:pharmacology*
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; D011806:Quinolinium Compounds; C050531:SRI 63-441; C045856:ginkgolide B