title: The influence of HLA antigens on progression of alcoholic liver disease.
abstract: The aim of our study was to elucidate further possible genetic influences on the incidence and progression of alcoholic liver disease. We determined HLA A, B and DR antigens in a well-controlled group of chronic alcoholics with and without liver disease, in repeated liver biopsies over period of 8.1 years (+/- 0.4 SEM). Patients with the antigen B 35 had an increased incidence of alcoholic liver cirrhosis, and especially a more rapid progression to cirrhosis (p less than 0.01). Increased susceptibility of these patients was shown by a more rapid progression of liver disease, despite the consumation of less alcohol over a shorter period. Results of this long-term study suggest that there is a sub-group of alcoholics genetically predisposed to higher susceptibility with more rapid deterioration of alcohol-induced liver disease.
authors.affiliation: Department of Internal Medicine, University of Basel, Switzerland.
authors.forename: U A
authors.initials: UA
authors.lastname: Marbet
authors.forename: G A
authors.initials: GA
authors.lastname: Stalder
authors.forename: G
authors.initials: G
authors.lastname: Thiel
authors.forename: L
authors.initials: L
authors.lastname: Bianchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D015797:HLA-B35 Antigen; D006681:HLA-D Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D008099:Liver / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D006680:HLA Antigens; D015797:HLA-B35 Antigen; D006681:HLA-D Antigens; D006684:HLA-DR Antigens