[T-cell immunodeficiency in mice receiving lectin and cyclophosphamide].
Cyclophosphamide injections to mice following T cell mitogen (lectins from Lens culinaris and concanavalin A) were shown to suppress (20-40-fold) thymus-dependent response to SRBC. At the same time no damage-specific and polyclonal response to thymus-independent antigen and polyclonal activator of B cells--lipopolysaccharide--has been observed. Injections of lectin and cyclophosphamide to mice prevented the onset of DTH reaction to SRBC and induction of antigen-specific DTH suppressor cells. Thus, cyclophosphamide injection after T cell mitogen leads to T-cell anergy, with B-cell activity remaining unchanged.
Fontalin
L N
LN
Kondrat'eva
T K
TK
Mikheeva
N V
NV
D000818:Animals; D003520:Cyclophosphamide / Q000008:administration & dosage*; D007111:Immunity, Cellular / Q000187:drug effects*; D037102:Lectins / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D037121:Plant Lectins; D013601:T-Lymphocytes / Q000276:immunology*
D037102:Lectins; D037121:Plant Lectins; C033619:lentil lectin; D003520:Cyclophosphamide
T-kletochnyĭ immunodefitsit u mysheĭ, poluchivshikh lektin i tsiklofosfamid.