title: Cervical chemonucleolysis in the dog. A surgical technique.
abstract: Cervical chemonucleolysis performed surgically in 16 clinically normal 4 and 10 year old Beagle dogs was well tolerated. The dosage of chymopapain per intervertebral disc was 200 or 500 U. Disc space narrowing was radiographically visible by day 1. By gross and histologic examination, there was lysis of the nucleus pulposus (NP) and perinuclear annulus fibrosus (AF). No observable differences due to ages of the dogs or doses of the enzyme were seen.
authors.affiliation: Department of Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: M A
authors.initials: MA
authors.lastname: Atilola
authors.forename: C S
authors.initials: CS
authors.lastname: Bailey
authors.forename: J P
authors.initials: JP
authors.lastname: Morgan
mesh_terms: D000367:Age Factors; D000818:Animals; D002574:Cervical Vertebrae; D002917:Chymopapain / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D007403:Intervertebral Disc / Q000000981:diagnostic imaging; D007404:Intervertebral Disc Chemolysis / Q000662:veterinary*; D007405:Intervertebral Disc Displacement / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D011859:Radiography; D011897:Random Allocation
chemical_list: D002917:Chymopapain