title: Cloprostenol prevents reperfusion induced fibrillation in isolated Langendorff heart preparation of guinea-pigs.
abstract: Cloprostenol, a synthetic derivative of prostaglandin F2 alpha, exhibits antiarrhythmic properties against reperfusion induced fibrillation in guinea-pig hearts in vitro. It decreases the incidence of fibrillation from 75.0% to 0%. This antifibrillatory effect of cloprostenol could be confirmed also by in vivo experiments.
authors.affiliation: Department of Pharmacology and Toxicology, Martin Luther University, Halle, GDR.
authors.forename: A
authors.initials: A
authors.lastname: Riedel
authors.forename: R
authors.initials: R
authors.lastname: Desselberger
authors.forename: H J
authors.initials: HJ
authors.lastname: Mest
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D003008:Cloprostenol / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D066298:In Vitro Techniques; D010477:Perfusion; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*
chemical_list: D011461:Prostaglandins F, Synthetic; D003008:Cloprostenol