Relation between individual and ensemble release kinetics of indomethacin from microspheres.
Indomethacin microspheres based on a combination of ethylcellulose and polyethyleneglycol were prepared using the solvent evaporation process. Release profiles of ensemble and individual microspheres were measured. Both were found to follow first-order kinetics, in contrast to what was expected. This was attributed to the fact that all the particles showed the same kinetic pattern and had a greater degree of homogeneity in the payload, mean particle size and shape, and k1 values than in ensembles of microcapsules.
Benita
S
S
Department of Pharmacy, School of Pharmacy, Hebrew University of Jerusalem, Israel.
Babay
D
D
Hoffman
A
A
Donbrow
M
M
D007213:Indomethacin / Q000493:pharmacokinetics*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size
D007213:Indomethacin