The effects of buspirone, a selective anxiolytic, on stress ulcer formation in rats.
The effects of buspirone hydrochloride were investigated on the formation of cold-immobilization gastric stress ulcers. Low doses significantly attenuated, while higher doses greatly potentiated gastric stress pathology. The dopamine antagonist haloperidol, and the agonist apomorphine respectively, reversed the buspirone effects. The role of dopamine in the expression of buspirone's effects is discussed, although other transmitter systems may mediate some of the actions of buspirone.
Sullivan
R M
RM
St. Francis Xavier University, Antigonish, N.S., Canada.
Henke
P G
PG
Ray
A
A
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002065:Buspirone / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000473:pathology; D013276:Stomach Ulcer / Q000473:pathology*; D013312:Stress, Physiological
D006220:Haloperidol; D001058:Apomorphine; D002065:Buspirone; D004298:Dopamine