title: Pharmacologic modulation of acute ocular inflammation. I. Adenosine.
abstract: Modulation of signal transduction at the surface of inflammatory cells appears to influence acute inflammation. Adenosine, a well-known chemical messenger, inhibits the production of superoxide by stimulated neutrophils. In experimental allergic uveitis induced by sensitization with retinal 's' antigen, treatment with adenosine produced a marked reduction in the expected inflammation.
authors.affiliation: Center for Sight, Georgetown University, Washington, D.C.
authors.forename: G E
authors.initials: GE
authors.lastname: Marak
authors.forename: Y
authors.initials: Y
authors.lastname: de Kozak
authors.forename: J P
authors.initials: JP
authors.lastname: Faure
authors.forename: N A
authors.initials: NA
authors.lastname: Rao
authors.forename: J L
authors.initials: JL
authors.lastname: Romero
authors.forename: P A
authors.initials: PA
authors.lastname: Ward
authors.forename: G O
authors.initials: GO
authors.lastname: Till
mesh_terms: D000241:Adenosine / Q000627:therapeutic use*; D000818:Animals; D000941:Antigens / Q000276:immunology; D019393:Arrestin; D002829:Choroid / Q000473:pathology; D002833:Choroiditis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D005136:Eye Proteins / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D012160:Retina / Q000473:pathology; D012173:Retinitis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D014605:Uveitis / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000941:Antigens; D019393:Arrestin; D005136:Eye Proteins; D000241:Adenosine