title: Effect of methotrexate on local cerebral blood flow in conscious rats.
abstract: The effect of methotrexate (MTX) on local cerebral blood flow (I-CBF) was studied with autoradiographic [14C]-iodoantipyrine methods in normal conscious rats. I-CBF was reduced by 30-57% in the rats given MTX (100 mg or 200 mg/body) as compared to that in the saline injected control group, but no dose-dependent effect was observed. The mechanism of I-CBF reduction by MTX was discussed.
authors.affiliation: Department of Internal Medicine, Research Institute for Brain and Blood Vessels-Akita, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Mizusawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kondoh
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: H
authors.initials: H
authors.lastname: Nakamichi
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Komatsu
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Kudoh
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Ono
mesh_terms: D000818:Animals; D001345:Autoradiography; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003243:Consciousness; D008297:Male; D008727:Methotrexate / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008727:Methotrexate