[The effect of azoxybenzene on microsomal liver enzymes in the rat].
Oral administrations of azoxybenzene (0, 25, 50 and 100 mg/kg b.w.) over a period up to 7 days caused a time and dose dependent decrease in the amount of cytochrome P-450 as well as in the ability of aminopyrine-N-demethylation and aniline hydroxylation in the hepatic microsomes of male and female rats. In both sexes there were retardations in the body weight gain and increases in the relative weight of the liver. The amount of the microsomal cytochrome b5 was increased.
Plass
R
R
Zentralinstitut für Ernährung in Potsdam-Rehbrücke, Akademie der Wissenschaften der DDR.
Lewerenz
H J
HJ
Ozierenski
B
B
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D015786:Cytochromes b5; D005260:Female; D007306:Insecticides / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001391:Azo Compounds; D003573:Cytochrome b Group; D007306:Insecticides; D011506:Proteins; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D000633:Aminopyrine N-Demethylase; C046115:fenazox
Einfluss von Azoxybenzen auf mikrosomale Leberenzyme der Ratte.