[The nature of immunodeficiency induced by injections of lectins and cyclophosphamide].
Consecutive injections of T-cell mitogen (LcA, Con A) and cyclophosphamide (CY) produce an inhibition of T-cell, but not B-cell functions. This phenomenon was not a result of suppressor-cell activity of the action of some suppressor serum factors. Immunoreactivity of mice, treated with Con A CY is restored by thymocytes from intact donors, but not bone marrow cells. Using, monoclonal antibodies to Thy-1.2 antigen or anti-Ig serum it has been shown that pretreatment of mice with lectin and CY resulted in a decrease in T-cell, but not B-cell number in comparison with control mice. The above facts are indicative of CY-mediated elimination of T cells involved in proliferation and differentiation by lectin.
Kondrat'eva
T K
TK
Mikheeva
N V
NV
Fontalin
L N
LN
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D003520:Cyclophosphamide / Q000494:pharmacology*; D003601:Cytotoxicity Tests, Immunologic; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced* / Q000276:immunology; D037102:Lectins / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D037102:Lectins; D003520:Cyclophosphamide
Priroda immunodefitsita, indutsirovannogo in''ektsiiami lektinov i tsiklofosfamida.