A diet containing n-3 and n-6 fatty acids favorably alters the renal phospholipids, eicosanoid synthesis and plasma lipids in nephrotic rats.
The nephrotic syndrome was induced in rats by intravenous adriamycin (3 mg/kg). The rats were then divided into four groups which, for six weeks, were pair-fed diets containing beef tallow (BT), fish oil (FO), a source of n-3 fatty acids, evening primrose oil (EPO), a source of n-6 fatty acids, or a combination of evening primrose oil and fish oil, 75:25 (EPO:FO). The fat content of the diets was 15%. Significant incorporation of the fatty acids into kidney phospholipids was demonstrated. Diets containing FO, EPO and EPO:FO lowered plasma triglycerides and total cholesterol levels as compared with diets containing BT. Only EPO:FO raised high density lipoprotein (HDL) cholesterol levels, as compared with BT. The combination EPO:FO prevented the tenfold suppression of aortic 6-keto-PGF1 alpha caused by FO. These changes in plasma lipids and eicosanoid production are potentially antiatherogenic and may prevent glomerular sclerosis. The combination of EPO and FO, containing n-6 and n-3 fatty acids may offer advantages over either family of fatty acids in this model of nephrotic syndrome.
Barcelli
U O
UO
Department of Internal Medicine, University of Cincinnati Medical Center, OH 45267-0585.
Beach
D C
DC
Thompson
B
B
Weiss
M
M
Pollak
V E
VE
D000818:Animals; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D005228:Fatty Acids, Essential / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis / Q000494:pharmacology*; D005260:Female; D005395:Fish Oils / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008041:Linoleic Acids; D008055:Lipids / Q000097:blood; D009404:Nephrotic Syndrome / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D031665:Oenothera biennis; D010743:Phospholipids / Q000378:metabolism; D010938:Plant Oils; D051381:Rats; D011919:Rats, Inbred Strains; D017965:gamma-Linolenic Acid
D004042:Dietary Fats, Unsaturated; D005228:Fatty Acids, Essential; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D008041:Linoleic Acids; D008055:Lipids; D010743:Phospholipids; D010938:Plant Oils; C028498:evening primrose oil; D017965:gamma-Linolenic Acid