title: [Rapidly progressing glomerulonephritis developing against a background of idiopathic nephrotic syndrome].
abstract: A case is presented of a woman with idiopathic nephrotic syndrome--mesangioproliferative glomerulonephritis who after a 7-year therapeutic remission developed a rapidly progressing (semilunar) glomerulonephritis with a severe nephrotic syndrome, arterial hypertension, anemia, renal failure. The patient was not influenced by the treatment with ordinary doses of glucocorticosteroids and temporarily improved by the combined "pulse" methylprednisolone, immunosuppressive and heparin treatment. The possible pathogenetic mechanisms which may have played a role in the transition of the idiopathic nephrotic syndrome into a rapidly progressing glomerulonephritis are discussed.
authors.forename: D
authors.initials: D
authors.lastname: Monova
authors.forename: N
authors.initials: N
authors.lastname: Belovezhdov
authors.forename: V
authors.initials: V
authors.lastname: Minova
authors.forename: D
authors.initials: D
authors.lastname: Doĭchinov
mesh_terms: D000293:Adolescent; D001706:Biopsy; D003131:Combined Modality Therapy; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000473:pathology / Q000628:therapy; D009404:Nephrotic Syndrome / Q000150:complications* / Q000473:pathology / Q000628:therapy; D012008:Recurrence; D012074:Remission Induction; D013997:Time Factors
vernacular_title: Bŭrzo progresirasht glomerulonefrit, razvil se na fona na idiopatichen nefrozen sindrom.