title: Nasopharyngeal carriage and antibiotic resistance of Haemophilus influenzae in healthy children.
abstract: An investigation was undertaken to determine the isolation rate and antibiotic resistance of Haemophilus influenzae from the nasopharynx of young children. The 996 subjects studied were up to 6 years of age. H. influenzae was isolated from 304 (30.5%) and strains of capsular type b from 11 (1.1%). Age, sibling status, season, respiratory infection and antibiotic therapy all influenced isolation rates. The overall prevalence of antibiotic resistance in the strains isolated was ampicillin 5.4% (all beta-lactamase producers), cefaclor 0.3%, chloramphenicol 1.3%, erythromycin 38.2%, tetracycline 1.3%, trimethoprim 5.4% and sulphamethoxazole 0%. Ampicillin resistance was more common in type b than non-capsulated strains.
authors.affiliation: Gwynedd Hospital, Penrhosgarnedd, Gwynedd, N. Wales.
authors.forename: A J
authors.initials: AJ
authors.lastname: Howard
authors.forename: K T
authors.initials: KT
authors.lastname: Dunkin
authors.forename: G W
authors.initials: GW
authors.lastname: Millar
mesh_terms: D000375:Aging; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002353:Carrier State / Q000453:epidemiology*; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D005191:Family Characteristics; D005260:Female; D006192:Haemophilus Infections / Q000453:epidemiology*; D006193:Haemophilus influenzae / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009305:Nasopharynx / Q000382:microbiology*; D012141:Respiratory Tract Infections / Q000382:microbiology; D012621:Seasons
chemical_list: D000900:Anti-Bacterial Agents