title: Effect of malathion and endosulfan on brain acetylcholinesterase and ovarian steroidogenesis of Channa punctatus (Bloch).
abstract: The effect of sublethal concentrations of malathion (organophosphorus insecticide) and endosulfan (organochlorine insecticide) was investigated in Channa punctatus. Brain acetylcholinesterase (AchE) and ovarian delta 5,3 beta-hydroxysteroid dehydrogenase (delta 5,3 beta-HSD) and glucose-6-phosphate dehydrogenase (G-6-PD) activities were studied. Apart from the loss of stage II and III oocytes, the absence of delta 5,3 beta-HSD and G-6-PD activity indicating the inhibition of steroidogenesis was seen in the malathion- and endosulfan-treated fish ovaries. Malathion demonstrated a dose-dependent inhibition of brain AchE activity, whereas endosulfan caused no significant reduction of AchE activity.
authors.affiliation: Department of Zoology, Banaras Hindu University, Varanasi, India.
authors.forename: R M
authors.initials: RM
authors.lastname: Inbaraj
authors.forename: S
authors.initials: S
authors.lastname: Haider
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002800:Cholinesterase Inhibitors; D004726:Endosulfan / Q000494:pharmacology*; D005260:Female; D005399:Fishes / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006651:Histocytochemistry; D008294:Malathion / Q000494:pharmacology*; D009865:Oocytes / Q000201:enzymology; D010053:Ovary / Q000201:enzymology*; D012016:Reference Values
chemical_list: D002800:Cholinesterase Inhibitors; D015096:3-Hydroxysteroid Dehydrogenases; C031954:delta(5)-3 beta-hydroxysteroid dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D000110:Acetylcholinesterase; D004726:Endosulfan; D008294:Malathion