Differential diagnosis of solitary pulmonary nodules with positron emission tomography using [11C]L-methionine.
Two patients with solitary pulmonary nodules, 1.5-2.0 cm in diameter, were studied by positron emission tomography using [11C-Methyl]L-methionine (11C-Met). Case 1 showed high accumulation of 11C-Met in the tumor, and a tumor/muscle ratio of 6.0 suggesting malignancy. Tissue obtained by biopsy revealed a squamous cell carcinoma. Case 2 showed nonspecific isotope accumulation in the tumor, and a tumor/muscle ratio of 1.2 suggesting a benign lesion. Lung biopsy demonstrated granuloma. Positron emission tomography with 11C-Met seems to be useful for the differential diagnosis of solitary lung nodules.
Kubota
K
K
Department of Radiology and Nuclear Medicine, Tohoku University, Sendai, Japan.
Matsuzawa
T
T
Fujiwara
T
T
Abe
Y
Y
Ito
M
M
Hatazawa
J
J
Ido
T
T
Ishiwata
K
K
Watanuki
S
S
D000368:Aged; D002250:Carbon Radioisotopes; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005260:Female; D006099:Granuloma / Q000000981:diagnostic imaging; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008715:Methionine; D008875:Middle Aged; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D008715:Methionine