title: Reductions in maternal food and water intake account for prenatal stress effects on neurobehavioral development in B6D2F2 mice.
abstract: This study evaluated the role of stress-induced reductions in food intake in pregnant B6D2F1 mice in the production of developmental abnormalities in the offspring. One group of dams underwent one hour of physical restraint stress twice daily from days 12 to 17 of gestation. A second group was not restrained but, during this period, each dam was pair-fed to a weight-matched partner in the stressed group. A third group was left undisturbed and allowed unlimited access to lab chow and water. The restraint stress procedure reduced the average daily food and water intake in the dams, resulting in lower maternal weights, with the unstressed pair-fed group being affected more severely than the stressed group. The offspring of both the stressed and pair-fed dams were lighter than the offspring of the dams fed ad lib on day 20 postconception, and exhibited lower brain weights on day 32 postconception. Neurobehavioral development, as assessed on a battery of sensorimotor tests on day 32 postconception, was retarded in the prenatally stressed pups in comparison to the ad lib pups, while the pair-fed pups did not differ from either group. There were no differences among any of the groups on day 50 body or brain weight, body or tail length, anogenital distance, or locomotion, rearing and defecation in the open field.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Psychology, University of Waterloo, Ontario, Canada.
authors.forename: G R
authors.initials: GR
authors.lastname: Ward
authors.forename: P E
authors.initials: PE
authors.lastname: Wainwright
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000833:Animals, Suckling / Q000254:growth & development*; D001522:Behavior, Animal / Q000502:physiology*; D001824:Body Constitution; D001921:Brain / Q000033:anatomy & histology; D004326:Drinking; D004435:Eating; D005260:Female; D008297:Male; D051379:Mice; D009929:Organ Size; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013312:Stress, Physiological / Q000503:physiopathology*