Early plasma cell recruitment in multiple myeloma following chemotherapy.
Therapy-induced modifications of bone marrow plasma cell kinetics were studied in three patients with myelomatosis. The investigation was performed prior to and 15 d after termination of a course of aggressive chemotherapy. An increase in the labelling index (40-212% of pretreatment values) with a corresponding reduction of Ts (5-34%) was observed in all cases. As a consequence of this combined variation, the fractional turnover rate (which represents the percentage of cells produced per unit time) was the parameter with the highest increment (54-276%). These results indicate that plasma cell recruitment occurs soon after chemotherapy and is characterized by a shorter S phase and a higher number of DNA-synthesizing cells.
Ucci
G
G
Dipartimento di Medicina Interna, Università di Pavia, Italy.
Riccardi
A
A
Dörmer
P
P
Danova
M
M
Luoni
R
R
D000368:Aged; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008558:Melphalan / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology*; D011241:Prednisone / Q000494:pharmacology / Q000627:therapeutic use; D013997:Time Factors
D004247:DNA; D008558:Melphalan; D011241:Prednisone