[Therapy of oral hairy leukoplakia with acyclovir].
Oral hairy leukoplakia was treated in six patients with (a) acyclovir (i.v. or p.o.), (b) 0.1% vitamin-A acid solution or (c) human beta-interferon-gel (10(5) I.E./g) in a total of 23 therapeutic courses. In 5/6 patients, acyclovir (7.5 mg/kg every 8 h i.v. or 5 x 400 mg p.o. over 5-10 days) led to partial (n = 1) or complete (n = 4) remission. After 1-6 months, however, the leukoplakia recurred in all cases. Vitamin-A acid solution (n = 3) led to remission in one and to improvement in the others. Human beta-interferon gel (n = 3) had no visible effect. The efficacy of acyclovir is further evidence of the concept that the Epstein-Barr virus is a major cause of oral hairy leukoplakia.
Ochsendorf
F R
FR
Zentrum der Dermatologie und Venerologie, Klinikum der J.W. Goethe-Universität Frankfurt/Main.
Schöfer
H
H
Runne
U
U
Milbradt
R
R
D000386:AIDS-Related Complex / Q000150:complications*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000212:Acyclovir / Q000008:administration & dosage*; D000284:Administration, Oral; D004359:Drug Therapy, Combination; D006801:Humans; D007262:Infusions, Intravenous; D007370:Interferon Type I / Q000008:administration & dosage; D007972:Leukoplakia, Oral / Q000188:drug therapy* / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology; D009367:Neoplasm Staging; D014212:Tretinoin / Q000008:administration & dosage
D007370:Interferon Type I; D014212:Tretinoin; D000212:Acyclovir
Therapie der oralen Haarleukoplakie mit Acyclovir.