[Mnemonic effects of substituted amides of imidazole-4(5)-carboxylic acid in rats].
The effects of four derivatives of imidazole-4(5)-carboxylic acid on the formation and extinction of the conditioned drinking reflex and the preservation of the conditioned response of passive avoidance after electroconvulsive shock or mechanic craniocerebral injury were studied during experiments on rats. N-methylamide of imidazole-4(5)-carboxylic acid exhibited the greatest psychostimulant and antiamnestic activity. Addition of beta-phenylisopropyl radical to NH2-group resulted in the appearance of depressant properties.
Shabanov
P D
PD
Piotrovskiĭ
L B
LB
Dumpis
M A
MA
D000577:Amides / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001930:Brain Injuries / Q000150:complications; D003214:Conditioning, Classical / Q000187:drug effects; D004327:Drinking Behavior / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D004924:Escape Reaction / Q000187:drug effects; D005108:Extinction, Psychological / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000188:drug therapy / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000187:drug effects; D013329:Structure-Activity Relationship
D000577:Amides; D007093:Imidazoles
Izuchenie mnesticheskikh éffektov zameshchennykh amidov imidazol-4(5)-karbonovoĭ kisloty u krys.