[Experimental parkinsonian syndrome in rats induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine].
Systemic administration of high doses of MPTP caused transient bradykinesia, "freezing" episodes, head tremors, hunching of the back and peripheral autonomic effects. Neurological syndrome was clearly dose-dependent. It has been established that Parkinson's syndrome is caused by high-amplitude paroxysmal discharges in the nucleus caudatis. It is concluded that the nucleus caudatis plays the role of a pathological determinant structure in the development of Parkinson's syndrome induced by MPTP.
Kryzhanovskiĭ
G N
GN
Atadzhanov
M A
MA
Zagorevskiĭ
V A
VA
Sharkova
L M
LM
Voronina
T A
TA
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D008297:Male; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D011725:Pyridines; D051381:Rats; D011919:Rats, Inbred Strains
D011725:Pyridines; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Eksperimental'nyĭ parkinsonicheskiĭ sindrom u krys, vyzvannyĭ 1-metil-4-fenil-1,2,3,6-tetragidropiridinom.