Detection of human B-lymphotropic virus (human herpesvirus 6) sequences in B cell lymphoma tissues of three patients.
A survey for HBLV (human B-lymphotropic herpesvirus or human herpesvirus 6) sequences by Southern blot analyses was performed on DNA obtained from a variety of pathologically defined tissues, including a number of lymphomas, leukemias, and tissues from other hematologic disorders. Of the over 50 specimens studied, viral sequences were detected in three lymphomas of B cell derivation: an Epstein-Barr virus-positive African Burkitt's lymphoma, a follicular large cell lymphoma (nodular histocytic lymphoma), and two Epstein-Barr virus-negative tumors from a patient with Sjogren's syndrome. These results are the first indication of HBLV sequences associated with B cell tumors in a limited number of cases and raise the possibility that the virus might be involved in the genesis of some B cell tumors.
Josephs
S F
SF
Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20205.
Buchbinder
A
A
Streicher
H Z
HZ
Ablashi
D V
DV
Salahuddin
S Z
SZ
Guo
H G
HG
Wong-Staal
F
F
Cossman
J
J
Raffeld
M
M
Sundeen
J
J
D000368:Aged; D001402:B-Lymphocytes / Q000032:analysis* / Q000382:microbiology; D002051:Burkitt Lymphoma / Q000032:analysis / Q000382:microbiology; D002675:Child, Preschool; D004279:DNA, Viral / Q000302:isolation & purification*; D005260:Female; D006564:Herpesviridae / Q000235:genetics*; D006801:Humans; D008223:Lymphoma / Q000032:analysis* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization
D004279:DNA, Viral