Pharmacokinetic profile of cefotetan in different clinical conditions.
The pharmacokinetic profile of cefotetan was studied in a group of hospitalized patients. The absorption of the molecule (after a single dose of 2 g/i.m.) was good and the drug was found to diffuse satisfactorily in the lungs, prostatic tissue, kidney and in the female genitalia.
Fraschini
F
F
Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
Scaglione
F
F
Mezzetti
M
M
Meroni
M
M
Cicchetti
F
F
Scarpazza
P
P
Scarpazza
G
G
D000328:Adult; D000368:Aged; D001980:Bronchi / Q000032:analysis; D015313:Cefotetan / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D005836:Genitalia, Female / Q000032:analysis; D006801:Humans; D007408:Intestinal Absorption; D007668:Kidney / Q000032:analysis; D008168:Lung / Q000032:analysis; D008173:Lung Diseases, Obstructive / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000032:analysis; D011897:Random Allocation; D013997:Time Factors; D014018:Tissue Distribution
D015313:Cefotetan