Potency ranking of two new topical corticosteroid creams containing 0.1% desonide or 0.05% halometasone utilising the human skin blanching assay.
The human blanching assay was used to assess the potency of two new proprietary corticosteroid creams. The blanching abilities of 0.1% desonide cream and 0.05% halometasone cream were evaluated relative to the blanching elicited by 0.05% clobetasol 17-propionate cream, 0.1% betamethasone 17-valerate cream and 0.05% clobetasone 17-butyrate cream. The results of the trial indicated that the 0.1% desonide cream falls into the potent group of topical corticosteroid preparations and the 0.05% halometasone cream falls into the moderately potent group.
Meyer
E
E
School of Pharmaceutical Sciences, Rhodes University, Grahamstown, South Africa.
Smith
E W
EW
Haigh
J M
JM
Kanfer
I
I
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001623:Betamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D001624:Betamethasone Valerate / Q000494:pharmacology; D003898:Desonide / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009824:Ointments; D011246:Pregnadienetriols / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects*; D012882:Skin Tests
D000893:Anti-Inflammatory Agents; D009824:Ointments; D011246:Pregnadienetriols; D001623:Betamethasone; D001624:Betamethasone Valerate; D003898:Desonide; C036518:halometasone