Retrospective assessment of dobutamine therapy for hypotension in anesthetized horses.
Dobutamine was infused (1.7 micrograms/kg/minute) into 200 anesthetized horses as treatment for hypotension. The horses had been premedicated with xylazine, and anesthesia was induced with guaifenesin and ketamine and maintained with halothane. One hundred fifty-seven horses (79%) responded with an average increase in systolic blood pressure of at least 10 mm Hg within 10 minutes. A cardiac arrhythmia developed in 56 horses (28%) after dobutamine administration: 34 with sinus bradycardia, 18 with atrioventricular block, 2 with premature atrial contractions, and 2 with atrioventricular dissociation. Dobutamine intravenous infusion was effective treatment for hypotension in horses anesthetized with halothane.
Donaldson
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LL
Marion duPont Scott Equine Medical Center, Virginia-Maryland Regional College of Veterinary Medicine, Leesburg, VA 24061.
D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects; D004280:Dobutamine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007022:Hypotension / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D012189:Retrospective Studies; D013997:Time Factors
D004280:Dobutamine