title: Stabilization of stannous pyrophosphate kits with gentisic acid.
abstract: We evaluated the ability of gentisic acid, an antioxidant, to stabilize stannous pyrophosphate (Sn:PPi) kits and extend the shelf-life of the kit after reconstitution. In vitro studies showed that gentisic acid (0.5 mg/mL) stabilized the stannous ion against oxidation by various levels of exogenous hydrogen peroxide. In patients who received stabilized Sn:PPi for in vivo red blood cell labelling, the left ventricle-to-background activity ratio was significantly higher than that in patients who received a standard formation of Sn:PPi. Gentisic acid is now used routinely in the Sn:PPi kit formulation in this institution.
authors.affiliation: Division of Nuclear Medicine, Ottawa Civic Hospital, Ontario, Canada.
authors.forename: J R
authors.initials: JR
authors.lastname: Ballinger
authors.forename: J
authors.initials: J
authors.lastname: Pygas
authors.forename: B
authors.initials: B
authors.lastname: Gerson
authors.forename: K Y
authors.initials: KY
authors.lastname: Gulenchyn
mesh_terms: D004355:Drug Stability; D005841:Gentisates; D011122:Polyphosphates; D011933:Reagent Kits, Diagnostic; D014003:Tin Polyphosphates
chemical_list: D005841:Gentisates; D011122:Polyphosphates; D011933:Reagent Kits, Diagnostic; D014003:Tin Polyphosphates