title: Comparison of ticarcillin plus clavulanic acid with clindamycin and gentamicin in the treatment of postcesarean endomyometritis.
abstract: The efficacy of a single antibiotic--Timentin (ticarcillin with clavulanic acid)--was compared with a standard two antibiotic regimen (clindamycin and gentamicin) for the treatment of endomyometritis after cesarean delivery. The regimens were 3 grams of ticarcillin plus 100 milligrams of clavulanic acid given intravenously every four hours, or 600 milligrams of clindamycin given intravenously every six hours plus 3 to 5 milligrams per kilogram per day of gentamicin given intramuscularly. The diagnosis of endomyometritis was based upon an oral temperature of 100.4 degrees F. or higher on any two occasions, excluding the first 24 hours post partum, uterine tenderness and the absence of another focus of infection. Ninety-one patients were treated. Treatment failure rates were three of 49 in the clindamycin and gentamicin group and four of 42 of the ticarcillin plus clavulanic acid group. Treatment failures did not appear to be different from successes demographically or in risk factors for endomyometritis. The results of this study suggest that ticarcillin with clavulanic acid is as effective in the treatment of postcesarean endomyometritis as the standard regimen of clindamycin and gentamicin.
authors.affiliation: University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Department of Obstetrics & Gynecology, Newark.
authors.forename: J J
authors.initials: JJ
authors.lastname: Apuzzio
authors.forename: V
authors.initials: V
authors.lastname: Ganesh
authors.forename: Z
authors.initials: Z
authors.lastname: Kaminski
authors.forename: B
authors.initials: B
authors.lastname: Bergen
authors.forename: B
authors.initials: B
authors.lastname: Holland
authors.forename: D B
authors.initials: DB
authors.lastname: Louria
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy*; D002585:Cesarean Section / Q000009:adverse effects*; D002969:Clavulanic Acids / Q000627:therapeutic use*; D002981:Clindamycin / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004338:Drug Combinations / Q000627:therapeutic use; D004716:Endometritis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D010406:Penicillins / Q000627:therapeutic use*; D013982:Ticarcillin / Q000627:therapeutic use*; D065093:beta-Lactamase Inhibitors
chemical_list: D002969:Clavulanic Acids; D004338:Drug Combinations; D005839:Gentamicins; D010406:Penicillins; D065093:beta-Lactamase Inhibitors; D002981:Clindamycin; C043215:ticarcillin-clavulanic acid; D013982:Ticarcillin