title: Determination of clozapine in human serum by capillary gas chromatography.
abstract: A gas chromatographic method using a fused-silica wide-bore capillary column and a nitrogen-specific detector for the determination of the antipsychotic agent clozapine in human serum is described. This method was found to be suitable for the determination of serum levels down to 1-2 ng/ml. The sensitivity, precision and accuracy of this method are adequate for studies on pharmacokinetics and bioavailability.
authors.affiliation: Institut für Klinische Pharmakologie der Medizinischen Akademie Carl Gustav Carus, Dresden, G.D.R.
authors.forename: K
authors.initials: K
authors.lastname: Richter
mesh_terms: D002849:Chromatography, Gas; D003024:Clozapine / Q000097:blood*; D003984:Dibenzazepines / Q000097:blood*; D006801:Humans
chemical_list: D003984:Dibenzazepines; D003024:Clozapine