Profound suppression of lymphocyte function in early biliary obstruction.
The blastogenic response to mitogens was studied in spleen and lymph node cells from four groups of Lewis rats at 1 to 2, 3 to 5, 6 to 9 and 10 to 14 days, respectively, after common bile duct ligation (CBD) or sham celiotomy (SC). Suppression in the splenocytes' mitogenic response to concanavalin A and phytohemagglutinin was noted as early as 3 days after common bile duct ligation. The response remained suppressed during the period of observation. Lymph node cells manifested a suppressed response to concanavalin A and phytohemagglutinin after 4 days of jaundice. No alteration in splenocyte response to lipopolysaccharide was observed. There was no correlation with the level of serum bilirubin.
Feduccia
T D
TD
Department of Surgery, University of Mississippi School of Medicine, Jackson 39216-4505.
Scott-Conner
C E
CE
Grogan
J B
JB
D000818:Animals; D001663:Bilirubin / Q000097:blood; D001651:Cholestasis, Extrahepatic / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors
D008070:Lipopolysaccharides; D010835:Phytohemagglutinins; D003208:Concanavalin A; D001663:Bilirubin