title: Pachydermoperiostosis with gastric hypertrophy, anemia, and increased serum bone Gla-protein levels.
abstract: We evaluated a patient in whom pachydermoperiostosis occurred in conjunction with anemia and gastric hypertrophy. The mechanism of the anemia appears multifactorial because, besides a myelofibrosis, a serum inhibitor of the late stage of erythropoiesis was detected. The elevated serum bone Gla-protein (osteocalcin) favors the hypothesis that primary hypertrophic osteoarthropathy represents an imbalance between increased osteoblastic bone formation and normal bone resorption.
authors.affiliation: Unité de Dermatologie, Centre Hospitalier Universitaire, Bicêtre, France.
authors.forename: P Y
authors.initials: PY
authors.lastname: Venencie
authors.forename: G A
authors.initials: GA
authors.lastname: Boffa
authors.forename: P D
authors.initials: PD
authors.lastname: Delmas
authors.forename: O
authors.initials: O
authors.lastname: Verola
authors.forename: I
authors.initials: I
authors.lastname: Benkaïdali
authors.forename: J
authors.initials: J
authors.lastname: Frija
authors.forename: B
authors.initials: B
authors.lastname: Pillet
authors.forename: A
authors.initials: A
authors.lastname: Puissant
mesh_terms: D000328:Adult; D000740:Anemia / Q000150:complications*; D001706:Biopsy; D002135:Calcium-Binding Proteins / Q000097:blood*; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D006984:Hypertrophy; D008297:Male; D010004:Osteoarthropathy, Primary Hypertrophic / Q000097:blood / Q000150:complications* / Q000235:genetics / Q000473:pathology; D015675:Osteocalcin; D055728:Primary Myelofibrosis / Q000150:complications
chemical_list: D002135:Calcium-Binding Proteins; D015675:Osteocalcin