Investigations of the origin of the furan fatty acids (F-acids).
The possible role of linoleic acid as a biogenetic precursor of the furan fatty acids (F-acids) was investigated in in vivo experiments in the rat, using a C19 analogue of linoleic acid and gas chromatography-mass spectrometry. No evidence of incorporation of this compound into the F-acids was found. Using an improved analysis procedure by converting F-acids into their tetrahydrofuran derivatives (enabling a separation from the large amounts of normal fatty acids), F-acids (F3, F4 and F6) were detected in rat food, correcting earlier results. Quantification of F-acid intake with food and excretion of furandicarboxylic acids in the urine, suggested the possibility that the F-acids are not produced de novo in the rat, but instead accumulate in tissue after nutritional intake.
Gorst-Allman
C P
CP
National Chemical Research Laboratory, Council for Scientific and Industrial Research, Pretoria, Republic of South Africa.
Puchta
V
V
Spiteller
G
G
D000818:Animals; D004041:Dietary Fats / Q000302:isolation & purification / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis* / Q000302:isolation & purification; D005663:Furans / Q000096:biosynthesis* / Q000302:isolation & purification; D008956:Models, Chemical; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D004041:Dietary Fats; D005227:Fatty Acids; D005663:Furans