Metabolic clearance and production of diiodotyrosine in healthy man.
Metabolic clearance rate (MCR) and daily production rate (PR) of diiodotyrosine (DIT) were estimated using a constant infusion technique of trace amounts of [125-I]-DIT followed by chromatographical isolation of tracer. Median DIT MCR was in eight healthy subjects estimated to 162 l/day x 70 kg (range 135-242), whereas PR was 52 nmol/day x 70 kg (range 25-126). The median serum DIT concentration was 0.27 nmol/l (range 0.16-0.62). In five L-thyroxine substituted subjects without endogenous thyroxine (T4) production, serum DIT concentrations were below 0.02 nmol/l, suggesting that more than 94% of daily produced DIT is secreted by the thyroid gland.
Faber
J
J
Medical Department of E, Frederiksberg Hospital, Denmark.
Kirkegaard
C
C
Meinhold
H
H
Bregengaard
C
C
D000328:Adult; D004105:Diiodotyrosine / Q000096:biosynthesis / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008657:Metabolic Clearance Rate
D007457:Iodine Radioisotopes; D004105:Diiodotyrosine