[Pharmacokinetics of triamcinolone following oral administration].
Plasma levels of triamcinolone were measured by RIA (radioimmunoassay) on 10 patients following oral application of 16 mg triamcinolone (Delphicort), the pharmacokinetic parameters were calculated. The terminal half-life of 2.7 +/- 1.3 h and tmax of 1.9 +/- 0.5 h are in agreement with corresponding data of other glucocorticoids, whereas the normalized plasma concentration and the volume of distribution are different. The normalized volume of distribution for triamcinolone is twice the value of prednisolone or methylprednisolone, cmax is about 2/3 of the values of these two other glucocorticoids.
Pörtner
M
M
Institut für Pharmazeutische Chemie, Westfälischen Wilhelms-Universität, Münster/Westf.
Möllmann
H
H
Barth
J
J
Rohdewald
P
P
D000284:Administration, Oral; D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000097:blood; D006207:Half-Life; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D014221:Triamcinolone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D005938:Glucocorticoids; D014221:Triamcinolone
Pharmakokinetik von Triamcinolon nach oraler Verabreichung.