The art gene product of human immunodeficiency virus is required for replication.
A mutation that alters the initiation codon of the art gene of the human immunodeficiency virus renders the virus replication defective. The replication defect of this mutation can be complemented in trans by the art gene product. These findings indicate that the art protein is essential for replication and, as such, represents a good target for development of new antiviral agents that could be useful in the control of human immunodeficiency virus infection.
Terwilliger
E
E
Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
Burghoff
R
R
Sia
R
R
Sodroski
J
J
Haseltine
W
W
Rosen
C
C
D002478:Cells, Cultured; D003062:Codon / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D003673:Defective Viruses / Q000235:genetics / Q000502:physiology; D015694:Gene Products, rev; D005814:Genes, Viral; D006678:HIV / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008854:Microscopy, Electron; D009154:Mutation; D010957:Plasmids; D011533:Proviruses / Q000235:genetics / Q000502:physiology; D013601:T-Lymphocytes / Q000382:microbiology; D014162:Transfection; D014764:Viral Proteins / Q000235:genetics* / Q000502:physiology; D014779:Virus Replication; D054321:rev Gene Products, Human Immunodeficiency Virus
D003062:Codon; D004279:DNA, Viral; D015694:Gene Products, rev; D014764:Viral Proteins; D054321:rev Gene Products, Human Immunodeficiency Virus