Effect of methotrexate on local cerebral blood flow in conscious rats.
The effect of methotrexate (MTX) on local cerebral blood flow (I-CBF) was studied with autoradiographic [14C]-iodoantipyrine methods in normal conscious rats. I-CBF was reduced by 30-57% in the rats given MTX (100 mg or 200 mg/body) as compared to that in the saline injected control group, but no dose-dependent effect was observed. The mechanism of I-CBF reduction by MTX was discussed.
Mizusawa
S
S
Department of Internal Medicine, Research Institute for Brain and Blood Vessels-Akita, Japan.
Kondoh
Y
Y
Murakami
M
M
Nakamichi
H
H
Sasaki
H
H
Komatsu
K
K
Takahashi
A
A
Kudoh
Y
Y
Watanabe
K
K
Ono
Y
Y
D000818:Animals; D001345:Autoradiography; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003243:Consciousness; D008297:Male; D008727:Methotrexate / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D008727:Methotrexate