title: Epidemiological and genetic study of 200 cases of oral cleft in the Emilia Romagna region of northern Italy.
abstract: Epidemiological and genetic variables in clefts were analyzed during the years 1978-1986 in a case-control study of congenital malformations in the Emilia Romagna region of northern Italy. Among 150,168 newborns, 200 cases of cleft were detected, yielding a prevalence of 1.33 per 1,000. These clefts consisted of 112 (0.075%) cases of cleft lip with or without cleft palate (CL +/- P) and 88 cases (0.058%) of cleft palate (CP). Coexisting abnormalities were found in 32% of cases. The heritability coefficient of CL +/- P was 0.84. No cluster in time or space could be demonstrated. Epilepsy was the only maternal risk factor found to be correlated with clefts. A predominance of males was found among CL +/- P cases.
authors.affiliation: Istituto di Genetica Medica, Università Ferrara, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Calzolari
authors.forename: M
authors.initials: M
authors.lastname: Milan
authors.forename: G B
authors.initials: GB
authors.lastname: Cavazzuti
authors.forename: G
authors.initials: G
authors.lastname: Cocchi
authors.forename: E
authors.initials: E
authors.lastname: Gandini
authors.forename: C
authors.initials: C
authors.lastname: Magnani
authors.forename: M
authors.initials: M
authors.lastname: Moretti
authors.forename: G P
authors.initials: GP
authors.lastname: Garani
authors.forename: G P
authors.initials: GP
authors.lastname: Salvioli
authors.forename: S
authors.initials: S
authors.lastname: Volpato
mesh_terms: D002971:Cleft Lip / Q000453:epidemiology* / Q000235:genetics; D002972:Cleft Palate / Q000453:epidemiology* / Q000235:genetics; D003241:Consanguinity; D003582:Cytogenetics; D006801:Humans; D007231:Infant, Newborn; D007558:Italy; D008297:Male; D012042:Registries; D012307:Risk Factors; D012744:Sex Ratio