title: B-lymphocytic hairy cells contain no HTLV-II DNA sequences.
abstract: HTLV-II has been found in some cases of the rare T-cell form of hairy-cell leukemia (HCL) and in a leukopenic chronic T-cell leukemia mimicking HCL. We asked whether the virus is implicated in the more frequent B-cell form of HCL. DNA extracted from the mononuclear cells derived from spleen (eight cases) or peripheral blood (eight cases) of 16 patients with the B-cell form of HCL was probed. No viral sequences were detected at levels of sensitivity as low as one viral genome in five cells. Therefore HTLV-II may not be involved in the B-cell form of HCL.
authors.affiliation: Joint Section of Hematology/Oncology, University of Chicago Medical Center.
authors.forename: T
authors.initials: T
authors.lastname: Lion
authors.forename: N
authors.initials: N
authors.lastname: Razvi
authors.forename: H M
authors.initials: HM
authors.lastname: Golomb
authors.forename: R H
authors.initials: RH
authors.lastname: Brownstein
mesh_terms: D001402:B-Lymphocytes / Q000032:analysis*; D001483:Base Sequence; D015139:Blotting, Southern; D004279:DNA, Viral / Q000302:isolation & purification*; D015367:Human T-lymphotropic virus 2 / Q000235:genetics*; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000235:genetics* / Q000473:pathology
chemical_list: D004279:DNA, Viral