A rapid approach to 11 alpha-hemisuccinylprogesterone synthesis.
The synthetic hapten 11 alpha-hemisuccinylprogesterone (11 alpha-hemisuccinyl-pregn-4-ene-3,20-dione), when linked to the appropriate macromolecular carrier, has been used successfully as a solid-phase antigen for progesterone detection in immunoassay. In this study the synthesis of 11 alpha-hemisuccinylprogesterone from 11 alpha-hydroxyprogesterone has been improved by using 4-dimethylaminopyridine (DMAP in refluxing dioxane, a highly nucleophilic polar solvent.
Mitchell
M O
MO
Angenics, Inc., Cambridge, MA 02139.
D015761:4-Aminopyridine / Q000031:analogs & derivatives*; D000631:Aminopyridines; D002855:Chromatography, Thin Layer; D004146:Dioxanes; D006908:Hydroxyprogesterones / Q000138:chemical synthesis*; D013997:Time Factors
D000631:Aminopyridines; D004146:Dioxanes; D006908:Hydroxyprogesterones; C030228:11-hydroxyprogesterone; C030250:progesterone 11-hemisuccinate; D015761:4-Aminopyridine; C003885:4-dimethylaminopyridine