Cerebral blood flow changes during sodium-lactate-induced panic attacks.
Dynamic single-photon emission computed axial tomography (CAT) with inhaled xenon-133 was used to measure regional cerebral blood flow in 10 drug-free patients with DSM-III-diagnosed panic disorder and in five normal control subjects. All subjects underwent regional cerebral blood flow studies while at rest or during normal saline infusion and during sodium lactate infusion. Six of the 10 patients and none of the control subjects experienced lactate-induced panic attacks. Lactate infusion markedly raised hemispheric blood flow levels in both control subjects and patients who did not panic. Patients who did panic experienced either a minimal increase or a decrease in hemispheric blood flow.
Stewart
R S
RS
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235-9070.
Devous
M D
MD
Rush
A J
AJ
Lane
L
L
Bonte
F J
FJ
D000328:Adult; D001008:Anxiety Disorders / Q000139:chemically induced* / Q000503:physiopathology; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D002540:Cerebral Cortex / Q000098:blood supply; D005239:Fear; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007773:Lactates / Q000008:administration & dosage; D019344:Lactic Acid; D008297:Male; D010200:Panic; D012039:Regional Blood Flow; D014055:Tomography, Emission-Computed; D014980:Xenon Radioisotopes
D007773:Lactates; D014980:Xenon Radioisotopes; D019344:Lactic Acid