Association of HLA-DQw3 (TA10-) with type I diabetes occurs with DR3/4 but not DR1/4 patients.
We have shown in previous studies that the TA10-subtype of HLA-DQw3 is significantly increased in HLA-DR4 type I (insulin-dependent) diabetic patients. Data presented in this article indicate that this association only occurs in heterozygous DR3/4 patients and not in DR1/4 patients. Because there is an interactive effect of both DR3/4 and DR1/4 in type I diabetes, the data indicate that the contribution of DR4 haplotypes varies depending on the haplotype borne on the homologous chromosome. In addition, the frequency of the B44-DR4 haplotype was shown to be decreased in DQw3 (TA10-) diabetic subjects who were DR3/4 compared with those who were DR1/4 or DR4/x (a pooled group of patients with different DR alleles). This finding suggests that the decrease in the B44-DR4 haplotype in type I diabetes is not solely dependent on its linkage disequilibrium with the DQw3 (TA10+) allele but suggests there is an additional effect exerted independently.
Tait
B D
BD
Tissue Typing Laboratory, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Mraz
G
G
Harrison
L C
LC
D000483:Alleles; D001402:B-Lymphocytes / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D006681:HLA-D Antigens / Q000032:analysis*; D006683:HLA-DQ Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis* / Q000235:genetics; D015798:HLA-DR1 Antigen; D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans
D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; C051569:HLA-DQ3 antigen; D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen