Mechanism of action of high-load copper IUDs.
A comparative study was made of four intrauterine contraceptive devices: the Nova-T, MLCu250 Short, MLCu375, and the Gyne T. An endometrial biopsy was performed on the 25th day of the menstrual cycle. The tissue obtained was analyzed to determine estrogen and progesterone receptor concentration. After two years of IUD use, both estrogen and progesterone receptors decreased proportionally to the increased amount of copper in the IUD.
de Castro
A
A
Hospital La Paz, Departamento de Obstetricia y Ginecologia, Madrid, Spain.
Gonzalez-Gancedo
P
P
D000328:Adult; D001706:Biopsy; D004717:Endometrium / Q000502:physiology*; D005260:Female; D006801:Humans; D007435:Intrauterine Devices, Copper; D011960:Receptors, Estrogen / Q000502:physiology*; D011980:Receptors, Progesterone / Q000502:physiology*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone