Effects of kassinin, a tachykinin of the skin of the African frog Kassina senegalensis, on body fluid homeostasis in rats.
In Wistar rats loaded with SC hypertonic NaCl solution kassinin produces an inhibition of cell-dehydration drinking which lasts several hours. The long duration of the effect does not depend on a renal excretion of sodium but, hypothetically, on a redistribution of electrolytes between the extra- and the intra-cellular compartments of body fluids.
Perfumi
M
M
Institute of Pharmacology, University of Camerino, Italy.
de Caro
G
G
Panocka
I
I
Polidori
C
C
Massi
M
M
D000818:Animals; D001001:Anura; D001826:Body Fluids / Q000187:drug effects*; D004231:Diuresis / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D006706:Homeostasis / Q000187:drug effects*; D007276:Injections, Intraventricular; D015286:Kassinin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism
D015286:Kassinin; D012964:Sodium