Malignant pituitary tumors.
Pituitary malignancies are rare. The definition of pituitary malignancy is still subject to debate. Three types of malignancy with the description of clinical course and complete autopsy were presented; i) true carcinosarcoma, ii) ectopic sphenoid invasive tumor, and iii) post-irradiation sarcoma. The first true carcinosarcoma had a long natural tumor history of 46 years, ending in malignant transformation with extracranial metastasis from a pituitary adenoma. The second ectopic sphenoid tumor was prolactin-producing, locally invasive, with the intact pituitary gland. The third post-irradiation sarcoma was followed by chromophobe pituitary adenoma. The interval between irradiation to the adenoma and malignant transformation to fibrosarcoma was about 14 years.
Kameya
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Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
D000236:Adenoma / Q000473:pathology* / Q000532:radiotherapy; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D010911:Pituitary Neoplasms / Q000201:enzymology / Q000473:pathology* / Q000532:radiotherapy; D015175:Prolactinoma / Q000473:pathology*
D010751:Phosphopyruvate Hydratase