title: [Detection of ischemia with thallium-201 single photon emission computerized tomography (SPECT) and radionuclide ventriculography in comparison with stress cineventriculography].
abstract: The accuracy of radionuclide techniques for detection of exercise-induced myocardial ischemia was analyzed with TL-201 single-photon emission computer tomography (SPECT) and gated blood pool ventriculography in 31 patients. Reversible and persistent perfusion defects in the biphasic SPECT studies, parametric phase and amplitude images and global indices of left ventricular function were evaluated and compared to the results of exercise cineventriculography. Out of 25 patients with coronary heart disease, 20 had exercise-induced ischemia and 17 patients had a prior myocardial infarction. SPECT detected ischemia with a sensitivity of 85% and a specificity of 100%, gated blood pool ventriculography had a sensitivity of 60% and a specificity of 91%. Both scintigraphic methods were comparable in the detection of myocardial infarcts (SPECT/gated blood pool ventriculography: sensitivity 88%/82%; specificity 100%/93%; positive predictive value 100%/93%). A difference in detection of ischemia between both methods was found in patients with myocardial infarct and additional ischemia: all patients with additional ischemia were detected by SPECT, whereas gated blood pool ventriculography failed to identify the additional ischemia in 1/4 of these patients (p less than 0.05).
authors.affiliation: Medizinische Klinik, Abt. III, Universität Tübingen.
authors.forename: H M
authors.initials: HM
authors.lastname: Hoffmeister
authors.forename: H
authors.initials: H
authors.lastname: Hanke
authors.forename: R
authors.initials: R
authors.lastname: Unterberg
authors.forename: W
authors.initials: W
authors.lastname: Voelker
authors.forename: W
authors.initials: W
authors.lastname: Müller-Schauenburg
authors.forename: K R
authors.initials: KR
authors.lastname: Karsch
mesh_terms: D002302:Cardiac Output; D002932:Cineangiography; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D004912:Erythrocytes; D005080:Exercise Test; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000000981:diagnostic imaging; D013667:Technetium; D013794:Thallium Radioisotopes; D014055:Tomography, Emission-Computed
chemical_list: D013794:Thallium Radioisotopes; D013667:Technetium
vernacular_title: Ischämieerkennung mit Thallium-201-Single-Photon-Emissionscomputertomographie (SPECT) und Radionuklidventrikulographie im Vergleich zur Belastungscineventrikulographie.