Planning mantle radiation therapy in patients with Hodgkin disease: role of gallium-67 scintigraphy.
Detection of all sites of lymphoma is imperative for accurate planning of radiation therapy. In patients with Hodgkin disease, mantle radiation is used to treat the thoracic lymph nodes; in those with early-stage or nonbulky disease, mantle and paraaortic radiation may be the only treatment given. CT scanning of the chest adds important information to that obtained from chest radiographs. Gallium-67 scintigraphy has also been used to provide additional information on sites of active tumor. To determine the usefulness of 67Ga-citrate scintigraphy in planning the portals for radiation therapy, we analyzed the radiation treatment plans in 26 consecutive patients with Hodgkin disease; in all 26 patients, the disease had been staged by chest radiographs, chest CT scans, and gallium-67 images. Gallium-67 imaging alone provided unique information that affected the treatment plans in three patients (12%). The combined results of gallium-67 imaging and CT scans influenced the planning of radiation therapy in eight patients (31%). Gallium-67 imaging was found to be an important adjunctive study for optimal planning of radiation therapy in patients with Hodgkin disease.
Jochelson
M S
MS
Department of Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Herman
T S
TS
Stomper
P C
PC
Mauch
P M
PM
Kaplan
W D
WD
D005710:Gallium Radioisotopes; D006689:Hodgkin Disease / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D006801:Humans; D013902:Radiography, Thoracic; D011877:Radionuclide Imaging; D013899:Thoracic Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy; D013909:Thorax / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
D005710:Gallium Radioisotopes