[Ion pair-HPLC of a pharmaceutical multicomponent system].
A multicomponent system of non-ionic (methyl- and propylhydroxybenzoate) and ionic (theophylline, phenobarbital, atropine methobromide, demelverine hydrochloride) analytes, which are applied in therapy as bronchospasmolytically effective drug (Aminophyllin compositum tablets), was investigated by means of ion-pair-HPLC-technique on reversed phases. As ion-interaction-reagents (IIR) were tried alkylsulfonates and sodium cyclamate. The influence of some factors on retention was described. The use of "mixed" IIR for improvement of the separation was investigated.
Jira
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T
Sektion Pharmazie, Ernst-Moritz-Arndt-Universität Greifswald.
Beyrich
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T
D000628:Aminophylline / Q000032:analysis; D001285:Atropine / Q000032:analysis; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D005079:Excipients / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D010634:Phenobarbital / Q000032:analysis; D013607:Tablets
D004338:Drug Combinations; D005079:Excipients; D013607:Tablets; D000628:Aminophylline; D001285:Atropine; D010634:Phenobarbital
Ionenpaar-HPLC eines pharmazeutischen Mehrkomponentensystems.