Changes in the rat sleep-wake cycle produced by D,L-beta-(1-naphthyl)alanine, a tryptophan analog.
The effects of i.p. injections of D,L-beta-(1-naphthyl)alanine, a synthetic analog of tryptophan were tested on the rat sleep-waking cycle. Administration of 30, 60 and 120 mg/kg resulted in a significant increase in slow-wave sleep (SWS) and a decrease in paradoxical sleep (PS). These modifications were dose-dependent. These results were compared with those previously obtained with L-tryptophan and several analogs and discussed in relation with possible changes in central serotonergic activity.
Rogemont
C
C
INSERM U. 205, Department of Biological Chemistry, INSA, Villeurbanne, France.
Sarda
N
N
Gharib
A
A
Pacheco
H
H
D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects*
C059031:1-naphthylalanine; D000409:Alanine