Animal experiments for estimating the radiation exposure of human subjects by radioactive drugs.
The radiation exposure of human subjects is extrapolated from the elimination rate of radioactivity from the plasma and a single determination of the tissue distribution of radioactivity in rats. With an interval of 3-4 half-lives between administration and determination, the radiation exposure of an organ is underestimated only if the elimination rate from the organ is 5.5-12.9 times lower than from the plasma. Determining the elimination rate from the relevant organs is recommendable only if the radiation exposure calculated for the commonly used dose of 100 microCi per volunteer approaches the official yearly limit.
Schaumann
W
W
Research Department, Boehringer Mannheim GmbH, Mannheim, FRG.
Neubert
P
P
D000818:Animals; D004064:Digestive System / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D007700:Kinetics; D011868:Radioisotopes / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D051381:Rats; D013045:Species Specificity; D014018:Tissue Distribution
D011868:Radioisotopes