title: Anti-histone antibodies in schizophrenia and affective disorders.
abstract: Sera from 81 psychiatric patients (51 with schizophrenia and 30 with affective disorders) were analyzed using several assays in parallel for the presence of non-organ-specific autoantibodies, namely anti-nuclear antibodies, anti-deoxyribonucleic acid antibodies (native and denatured DNA), anti-histone antibodies, anti-centromere antibodies, and anti-nuclear antigen antibodies. Nine out of the 81 sera studied were positive for the presence of anti-nuclear antibodies. Moreover, in 15 patients, significant titers of anti-histone antibodies were detected. No correlation can be drawn concerning the presence of anti-histone antibodies and the clinical situation. Although no clear association was noted with a specific class of drugs, it cannot be excluded at present that the therapeutic regimen received by the patients may explain the results observed.
authors.affiliation: INSERM U 25-CNRS UA122, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Villemain
authors.forename: M
authors.initials: M
authors.lastname: Magnin
authors.forename: M N
authors.initials: MN
authors.lastname: Feuillet-Fieux
authors.forename: E
authors.initials: E
authors.lastname: Zarifian
authors.forename: H
authors.initials: H
authors.lastname: Loo
authors.forename: J F
authors.initials: JF
authors.lastname: Bach
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D001714:Bipolar Disorder / Q000276:immunology; D004247:DNA / Q000276:immunology; D003866:Depressive Disorder / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006657:Histones / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000276:immunology*; D012560:Schizophrenia, Catatonic / Q000276:immunology; D012562:Schizophrenia, Disorganized / Q000276:immunology; D012563:Schizophrenia, Paranoid / Q000276:immunology
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006657:Histones; D004247:DNA