title: Epidermal growth factor in plasma, serum and urine before and after prolonged exercise.
abstract: The substance concentration of epidermal growth factor immunoreactivity (EGF IR) and certain other components were studied in plasma, serum and urine from 25 individuals before and after a 2 h cross-country run. The substance concentration of plasma EGF IR increased from a median of 0.10 nM (range 0.04-0.26 nM) to a median of 0.16 nM (range 0.10-0.36 nM) after 2 h of exercise, while serum EGF showed no change. The values obtained for B-platelets were a median of 192 x 10(9)/litre (range 109-282 x 10(9)/litre) before the run, and a median of 265 x 10(9)/litre (range 216-387 x 10(9)/litre) after the run. No correlation was observed between the values obtained for B-platelets and the values for plasma or serum EGF IR. The substance concentration of EGF IR in urine increased from a median of 3.2 nM (range 0.5-7.7 nM) to a median of 7.0 nM (range 1.5-15.7 nM) after the run. Expressed relative to the output of carbamide the output of urinary EGF IR increased with a median factor of 2 following the run. Expressed relative to the output of creatinine no increase was observed.
authors.affiliation: Department of Clinical Chemistry, Central Hospital, Hillerød, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Konradsen
authors.forename: E
authors.initials: E
authors.lastname: Nexø
mesh_terms: D000293:Adolescent; D000328:Adult; D004815:Epidermal Growth Factor / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D010949:Plasma / Q000378:metabolism; D013997:Time Factors
chemical_list: D004815:Epidermal Growth Factor