Hemoglobin D-beta (0) thalassemia. A case report and family study.
Findings are presented on a Pakistani family in Doha, Qatar with hemoglobin D-Los Angeles (alpha 2 beta 3 121 (glutamine----glycine) and thalassemia trait. The propositus, a child, has hemoglobin D-beta(0) thalassemia, and suffers from moderately severe hemolytic anemia. The father has beta-thalassemia trait, and the mother is heterozygous for hemoglobin D-Los Angeles. This, the eighth confirmed case in the medical literature, is reported to emphasize its clinical manifestations and genetic basis.
Dawod
S T
ST
Department of Pediatrics, Hamad General Hospital, Qatar, Arabian Gulf.
Abulaban
M
M
Kamel
K
K
Huisman
T H
TH
D006455:Hemoglobins, Abnormal / Q000032:analysis / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D010154:Pakistan; D013789:Thalassemia / Q000235:genetics* / Q000473:pathology
D006455:Hemoglobins, Abnormal; C026237:hemoglobin D Punjab