Influence of the hypercycle on the error threshold: a stochastic approach.
The role of fluctuations on the error threshold of the hypercycle has been studied by a stochastic approach on a very simplified model. For this model, the master equation was derived and its unique steady state calculated. This state implies the extinction of the system. But the actual time necessary to reach the steady state may be astronomically long whereas for times of experimental interest the system could be near some quasi-stationary states. In order to explore this possibility a Gillespie simulation of the stochastic process has been carried out. These quasi-stationary states correspond to the deterministic steady states of the system. The error threshold shifts towards higher values of the quality factor Q. Moreover, information about the fluctuations around the quasi-stationary states is obtained. The results are discussed in relation to the deterministic states.
García-Tejedor
A
A
Departamento de Bioquímica y Biología Molecular I, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain.
Sanz-Nuño
J C
JC
Olarrea
J
J
Javier de la Rubia
F
F
Montero
F
F
D000818:Animals; D005075:Biological Evolution; D008954:Models, Biological; D011336:Probability; D013269:Stochastic Processes