A selected ion monitoring assay for triclosan in medical waste water.
A method for determinations of triclosan (TCS) and hexachlorophene (HCP) disinfectants in medical waste water by selected ion monitoring (SIM) using bithionol (BTN) as an internal standard compound has been developed. The method consists of the following procedures. (i) TCS and HCP in medical waste water were extracted and purified by an Extrelut column with ethyl acetate. (ii) The eluted TCS, HCP and BTN were converted to trimethylsilyl (TMS) derivatives with N,O-bis(trimethylsilyl)trifluoroacetamide-ethyl acetate (1:4). (iii) The TMS derivatives of TCS, HCP and BTN were identified and determined by SIM. Recoveries of these compounds added to medical waste water were more than 88% in amounts ranging from 1 to 10 micrograms. In the waters from our medical waste water treatment plant, TCS and HCP concentrations were found to be 0.43-8.01 and 0.24-4.69 micrograms l-1, respectively. The present method is superior to the pre-existing ones in quick separation, specificity and sensitivity.
Matsushima
H
H
Department of Hygiene, Hamamatsu University School of Medicine, Japan.
D008401:Gas Chromatography-Mass Spectrometry; D006582:Hexachlorophene / Q000032:analysis; D007202:Indicators and Reagents; D008506:Medical Waste / Q000032:analysis*; D010647:Phenyl Ethers / Q000032:analysis*; D012722:Sewage / Q000032:analysis*; D014260:Triclosan / Q000032:analysis*; D014297:Trimethylsilyl Compounds / Q000032:analysis; D014866:Waste Products / Q000032:analysis*
D007202:Indicators and Reagents; D008506:Medical Waste; D010647:Phenyl Ethers; D012722:Sewage; D014297:Trimethylsilyl Compounds; D014866:Waste Products; D014260:Triclosan; D006582:Hexachlorophene