Mechanism of lithium-induced augmentation of T-cell proliferation.
The mechanism whereby lithium augments mitogen-stimulated T-cell proliferation was investigated. Lithium in a concentration of 5mM caused a significant increase in interleukin 2 (IL-2) production after phytohemagglutinin (PHA) stimulation. Lithium also caused an increase in interleukin 1 production from peripheral blood monocytes. Lithium did not influence the expression of IL-2 receptors on T-cells. However, lithium did result in increased proliferative response to IL-2 in an IL-2 responsive cell line. Thus, lithium influences the T-cell proliferation response to mitogens in several ways, by stimulation of lymphokine and monokine production as well as by augmenting the response of IL-2 responsive cells to IL-2.
Kucharz
E J
EJ
Department of Medicine, Medical College of Wisconsin, Milwaukee 53226.
Sierakowski
S
S
Staite
N D
ND
Goodwin
J S
JS
D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D008094:Lithium / Q000494:pharmacology*; D011975:Receptors, Mitogen / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects*
D007375:Interleukin-1; D007376:Interleukin-2; D011975:Receptors, Mitogen; D008094:Lithium