title: Congenital diaphragmatic hernia: impact of preoperative stabilization. A prospective pilot study in 13 patients.
abstract: In case of congenital diaphragmatic hernia (CDH), survival generally depends not on prenatal diagnosis, planned delivery, and immediate postnatal operation, but on the gravity of pulmonary hypoplasia and persistent hypertension (PPH). Many vasoactive drugs have become available for lowering PPH, but the mortality rate for CDH still amounts to 40% to 70%. Preoperative stabilization might prevent or at least reduce the risk of PPH. This method was evaluated in a pilot study lasting 15 months and involving 13 patients. All were admitted to the pediatric surgical intensive care unit within six hours of birth, all requiring mechanical ventilation. Continuous suction of the stomach and bowel proved successful in reducing the mediastinal shift. Study parameters were alveolar-arterial oxygenation differences ((A-a)DO2), mean airway pressure (MAP), oxygenation index (OI), and ventilation index (VI), measured on admission and at set times before and after surgery. Eight patients did not survive, but in two cases death was not directly related to CDH. The following conclusions were reached: (1) satisfactory ventilation parameters on admission will remain good during the preoperative stabilization phase and will not be affected by its duration or by subsequent surgery, spelling survival; (2) unsatisfactory ventilation parameters on admission may improve with preoperative stabilization, giving these patients a better chance of survival; and (3) poor ventilation parameters on admission that fail to improve with preoperative stabilization will not improve with surgery or postoperatively, spelling death.
authors.affiliation: Department of Pediatric Surgery, Medical School of Erasmus University, Rotterdam, The Netherlands.
authors.forename: F W
authors.initials: FW
authors.lastname: Hazebroek
authors.forename: D
authors.initials: D
authors.lastname: Tibboel
authors.forename: A P
authors.initials: AP
authors.lastname: Bos
authors.forename: A W
authors.initials: AW
authors.lastname: Pattenier
authors.forename: G C
authors.initials: GC
authors.lastname: Madern
authors.forename: J H
authors.initials: JH
authors.lastname: Bergmeijer
authors.forename: J C
authors.initials: JC
authors.lastname: Molenaar
mesh_terms: D005260:Female; D006548:Hernia, Diaphragmatic / Q000601:surgery / Q000628:therapy; D065630:Hernias, Diaphragmatic, Congenital; D006611:High-Frequency Jet Ventilation / Q000379:methods; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010865:Pilot Projects; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D013396:Suction / Q000379:methods