title: Shift in phenotype of acute T-lymphocytic leukemia to eosinophilic leukemia: a case report.
abstract: Acute T-lymphocytic leukemia diagnosed in a 14-year old boy on the basis of typical cell morphology, as well as by membrane antigen analysis with monoclonal antibodies, shifted to the phenotype of an acute eosinophilic leukemia 5 months after the initiation of chemotherapy. The transformation was evident by a change in morphology of cells derived from bone marrow aspirates, by cytochemistry and by a shift in the membrane antigen pattern.
authors.affiliation: 2nd Department of Medicine, Vienna University Hospital.
authors.forename: P P
authors.initials: PP
authors.lastname: Preis
authors.forename: C C
authors.initials: CC
authors.lastname: Zielinski
authors.forename: W
authors.initials: W
authors.lastname: Linkesch
authors.forename: P
authors.initials: P
authors.lastname: Bettelheim
authors.forename: T
authors.initials: T
authors.lastname: Radaskiewicz
authors.forename: M
authors.initials: M
authors.lastname: Pavelka
authors.forename: O
authors.initials: O
authors.lastname: Haas
authors.forename: P
authors.initials: P
authors.lastname: Aiginger
mesh_terms: D000293:Adolescent; D000954:Antigens, Surface / Q000235:genetics; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D004804:Eosinophils / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000139:chemically induced / Q000235:genetics*; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D010641:Phenotype; D012074:Remission Induction; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D000954:Antigens, Surface