[Effect of PGE1 on the left ventricular ejection fraction].
12 patients with impaired left ventricular function were submitted to left ventricular ejection fraction measurements before and after increasing doses of PGE1 administered by i.v. or i.a. infusion. 6 responders out of the 12 patients showed a significant (p less than 0.01) improvement in LVEF, whereas the LVEF remained unchanged in the remaining 6 patients. 4 of the responders had received intravenous and 2 had received intraarterial PGE 1. Afterload reduction, venous tonisation, increased myocardial contractility and metabolic effects may be causative factors. These results suggest that PGE 1 therapy may be of therapeutic benefit in some patients with impaired LVEF.
Auinger
C
C
Nuklearmedizinische Abteilung, II. Medizinischen Universitätsklinik, Wien.
Weissel
M
M
Bergmann
H
H
Sinzinger
H
H
D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000627:therapeutic use*; D002303:Cardiac Output, Low / Q000188:drug therapy*; D009202:Cardiomyopathies / Q000150:complications; D003327:Coronary Disease / Q000150:complications; D005260:Female; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications; D013318:Stroke Volume / Q000187:drug effects*
D000527:Alprostadil
Einfluss von PGE1 auf die linksventrikuläre Auswurffraktion.