title: Effect of iron deficiency anaemia and its treatment on the absorption and elimination of phenformin.
abstract: 1. The extent of phenformin absorption and its rate of urinary excretion have been assessed in adult patients with iron deficiency anaemia, a condition which compromises gastrointestinal function. 2. Phenformin (100 mg) was administered orally to patients before treatment, three days after the start of a course of iron treatment (oral 300 mg b.d. or total intravenous iron) and at the end of 28 days, when haemoglobin was over 10 gm%. 3. No significant difference was found between mean total amounts of phenformin and 4-hydroxyphenformin excreted in urine, before treatment or after 3 or 28 days replacement therapy. It is concluded that phenformin absorption is not affected by iron deficiency. 4. In addition, iron deficiency had no significant effect on phenformin elimination half-life.
authors.affiliation: Department of Pharmacology, Seth G.S. Medical College, Bombay, India.
authors.forename: N A
authors.initials: NA
authors.lastname: Kshirsagar
authors.forename: Y S
authors.initials: YS
authors.lastname: Saraf
authors.forename: M V
authors.initials: MV
authors.lastname: Joshi
authors.forename: M R
authors.initials: MR
authors.lastname: Takle
authors.forename: S
authors.initials: S
authors.lastname: Pohujani
authors.forename: B C
authors.initials: BC
authors.lastname: Mehta
authors.forename: V N
authors.initials: VN
authors.lastname: Acharya
authors.forename: R S
authors.initials: RS
authors.lastname: Satoskar
mesh_terms: D000328:Adult; D000747:Anemia, Hypochromic / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption; D007501:Iron / Q000627:therapeutic use; D008297:Male; D010629:Phenformin / Q000031:analogs & derivatives / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: C027283:4-hydroxyphenformin; D010629:Phenformin; D007501:Iron