Inhibition of drug-gated chloride currents by calcium influx in frog sensory neurons.
In isolated and internally perfused frog sensory neurons, muscimol-, pentobarbital- and alpha-chloralose-induced Cl- currents were suppressed by voltage-dependent Ca2+ currents. The amount of chloride currents inhibited by Ca2+ influx developed in a hyperbolic manner as a function of Ca2+ influx. The increase in intracellular Ca2+ concentration also suppressed the currents carried by monovalent anions, such as Br-, I-, NO3- and HCOO-.
Akaike
N
N
Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Oyama
Y
Y
Tokutomi
N
N
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000502:physiology*; D002463:Cell Membrane Permeability; D002712:Chlorides / Q000502:physiology*; D007477:Ions; D009475:Neurons, Afferent / Q000502:physiology*; D011892:Rana catesbeiana; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D002712:Chlorides; D007477:Ions; D005680:gamma-Aminobutyric Acid; D002118:Calcium