[Possibility of the current segregation analysis to discriminate between monogenic and multifactorial types of inheritance of traits. The effect of the structure of family data on model robustness and power of the analysis].
The influence of sampling designs for robustness of the autosomal major locus model and the multifactorial model as well as possibility of segregation analysis to discriminate these models was studied. Nuclear families and 3-generation pedigrees were considered. It was found that robustness of models increased, when the size of sibships in nuclear families grows and when configuration of pedigrees is complicated. The resolution power of the analysis is always increased with size elevation of sibships, the highest effect of the analysis being observed for sibships of the size 3 or 4. Consideration of new generations is only advisable, if attracting sibs of these generations, the resolution power being increased, provided that the parameters of models are of high value.
Koroleva
A G
AG
Ageev
S V
SV
D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D010375:Pedigree; D012494:Sampling Studies
Issledovanie vozmozhnosti sovremennogo segregatsionnogo analiza razgranichivat' monogennyĭ i mul'tifaktorial'nyĭ tipy nasledovaniia priznakov. Vliianie struktury semeĭnykh dannykh na ustoĭchivost' modeleĭ i moshchnost' analiza.