title: Human T cell specific proteinase (HuTSP) is encoded by the T cell and natural killer cell specific human Hanukah factor (HuHF) gene.
abstract: HuTSP, a serine proteinase which is specifically associated with activated t lymphocytes, was purified to homogeneity and characterized. N-terminal amino acid sequencing revealed identity with a sequence predicted from the human Hanukah factor (HF) gene, which was isolated from a human T cell cDNA library. The dimeric structure of HuTSP, together with its extensive sequence homologies with the murine T cell specific proteinase, MTSP-1, suggests phylogenetic conservation of this serine proteinase family.
authors.affiliation: Max-Planck-Institut für Immunbiologie, Freiburg, FRG.
authors.forename: U
authors.initials: U
authors.lastname: Fruth
authors.forename: C
authors.initials: C
authors.lastname: Eckerskorn
authors.forename: F
authors.initials: F
authors.lastname: Lottspeich
authors.forename: M D
authors.initials: MD
authors.lastname: Kramer
authors.forename: M
authors.initials: M
authors.lastname: Prester
authors.forename: M M
authors.initials: MM
authors.lastname: Simon
mesh_terms: D000595:Amino Acid Sequence; D002460:Cell Line; D005796:Genes; D053804:Granzymes; D006801:Humans; D007694:Killer Cells, Natural / Q000201:enzymology*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D012697:Serine Endopeptidases / Q000235:genetics* / Q000302:isolation & purification; D013601:T-Lymphocytes / Q000201:enzymology*
chemical_list: D053804:Granzymes; D012697:Serine Endopeptidases; C509212:GZMA protein, human