title: In vitro susceptibility of bacteria to a ticarcillin-clavulanic acid combination.
abstract: In vitro testing of bacterial susceptibility to a combination of ticarcillin and clavulanic acid was done, using 406 aerobic gram-positive and gram-negative isolates (considered to be pathogens) cultured from equine and small animal specimens. A microdilution broth technique of susceptibility testing was performed, using trays with wells containing a range of doubling concentrations of dehydrated ticarcillin (range, 0.50 to 128 micrograms/ml) with fixed concentration of clavulanic acid (4 micrograms/ml). The following isolates of equine origin were (90%) susceptible to concentrations of ticarcillin and clavulanic acid combinations of less than or equal to 16 and 4 micrograms/ml, respectively: Staphylococcus aureus, S intermedius, Klebsiella pneumoniae, Enterobacter aerogenes, Ent agglomerans, Ent cloacae, Escherichia coli, Actinobacillus sp, Corynebacterium pseudotuberculosis, Rhodococcus equi, Proteus vulgaris, and Bordetella bronchiseptica. Isolates of small animal origin (90%) susceptible to less than or equal to 16 and 4 micrograms of ticarcillinclavulanic/ml included S aureus, S intermedius, Ent aerogenes, Ent agglomerans, Pasteurella multocida, B bronchiseptica, Pr mirabilis, and Serratia sp.
authors.affiliation: Diagnostic Laboratories, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
authors.forename: S E
authors.initials: SE
authors.lastname: Sparks
authors.forename: R L
authors.initials: RL
authors.lastname: Jones
authors.forename: W R
authors.initials: WR
authors.lastname: Kilgore
mesh_terms: D000828:Animal Population Groups / Q000382:microbiology; D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D002415:Cats; D002969:Clavulanic Acids / Q000008:administration & dosage* / Q000494:pharmacology; D004285:Dogs; D004359:Drug Therapy, Combination / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000008:administration & dosage*; D011817:Rabbits; D013982:Ticarcillin / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D002969:Clavulanic Acids; D010406:Penicillins; D013982:Ticarcillin