[The relation of the acetylation phenotype to the predisposition to typhoid fever and its clinical course].
Altogether 33 typhoid fever convalescents and 36 contacts of a control group were examined during an epidemic outbreak. In one year 17 former patients and 65 controls (persons who had been at the center of the outbreak but contracted no disease) were examined. Norsulfazole was used as a model agent to study an acetylation phenotype. Unimodal distribution of a degree of norsulfazole distribution was noted in the convalescents, bimodal distribution in the controls and patients examined in one year. Persons with a rapid type of acetylation were more predisposed to typhoid fever, and intoxication in them was more noticeable.
Musabaev
E I
EI
D000107:Acetylation; D003289:Convalescence; D004198:Disease Susceptibility; D006801:Humans; D010641:Phenotype; D012008:Recurrence; D000077589:Sulfathiazole; D013432:Sulfathiazoles / Q000493:pharmacokinetics / Q000652:urine; D014435:Typhoid Fever / Q000209:etiology / Q000378:metabolism*
D013432:Sulfathiazoles; D000077589:Sulfathiazole
Sviaz' fenotipa atsetilirovaniia s predraspolozhennost'iu k briushnomu tifu i ego klinicheskim techeniem.