title: The hemodynamic effects of intravenous ranitidine in intensive care unit patients: a double-blind prospective study.
abstract: The hemodynamic effects of intravenous ranitidine were studied in a prospective double-blind fashion in postoperative intensive care unit patients to determine if this H2 blocker produced the same transient fall in mean arterial pressure and systemic vascular resistance known to occur with cimetidine infusion. We found no statistically significant hemodynamic changes from baseline associated with infusion of 50 mg ranitidine over a 5-minute period. The different chemical ring structure of ranitidine and its effect on H2 vascular and cardiac receptors may account for these observations.
authors.affiliation: Department of Surgery, Mount Sinai Medical Center, City University of New York, New York 10029-6574.
authors.forename: D
authors.initials: D
authors.lastname: Onofrey
authors.forename: K M
authors.initials: KM
authors.lastname: Kelly
authors.forename: D R
authors.initials: DR
authors.lastname: Gentili
authors.forename: E
authors.initials: E
authors.lastname: Benjamin
authors.forename: T J
authors.initials: TJ
authors.lastname: Iberti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003422:Critical Care; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011899:Ranitidine / Q000494:pharmacology*
chemical_list: D011899:Ranitidine