Plasminogen activator and plasminogen activator inhibitor activities in a reference population.
The influence of age, gender, and aspirin ingestion on plasma levels of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) activities was studied in a reference population of 35 men and 35 women between the ages of 20 and 65 years. The t-PA values (mean +/- SD) in the women before and after 5 minutes of venous occlusion were 3.8 +/- 1.4 and 7.8 +/- 4.4 micrograms/L, respectively; in men these values were 3.3 +/- 1.2 and 8.8 +/- 8.9 micrograms/L. Men had higher mean PAI levels than did women (5.0 vs. 2.5 kU/L). T-PA showed an inverse relationship to PAI in both sexes. There was a negative correlation of t-PA levels with age, whereas PAI levels were positively correlated. The ingestion of a single dose of aspirin (650 mg) did not alter PAI or t-PA activities. This study indicates that factors such as age and sex may need to be considered when reference populations are developed for clinical studies of fibrinolysis.
Krishnamurti
C
C
Department of Hematology, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100.
Tang
D B
DB
Barr
C F
CF
Alving
B M
BM
D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000097:blood*; D015849:Plasminogen Inactivators; D012737:Sex Factors
D006023:Glycoproteins; D015849:Plasminogen Inactivators; D010960:Plasminogen Activators