title: Autonomic regulation of potassium release from human labial salivary glands in vitro.
abstract: Labial salivary-gland slices from normal human subjects were incubated in vitro according to various protocols. The autonomic regulation of these was significantly different from that of most major salivary glands. K release was stimulated by incubation with a cholinergic agonist but not with alpha- or beta-adrenergic agonists. The cholinergically-induced K release was dependent on agonist concentration and was inhibited by the addition of atropine, and by the removal of Ca in the presence of EGTA.
authors.affiliation: Department of Oral Biology, School of Dentistry, University of Washington, Seattle 98195.
authors.forename: K
authors.initials: K
authors.lastname: Izutsu
authors.forename: W
authors.initials: W
authors.lastname: Ensign
authors.forename: B
authors.initials: B
authors.lastname: Ramsey
authors.forename: M
authors.initials: M
authors.lastname: Schubert
authors.forename: B
authors.initials: B
authors.lastname: Allan
authors.forename: E
authors.initials: E
authors.lastname: Truelove
mesh_terms: D000328:Adult; D001285:Atropine / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D002217:Carbachol / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D011188:Potassium / Q000378:metabolism*; D012469:Salivary Glands / Q000378:metabolism*; D012470:Salivary Glands, Minor / Q000187:drug effects / Q000378:metabolism*
chemical_list: D001285:Atropine; D002217:Carbachol; D011188:Potassium; D002118:Calcium