[Effect of hydrocortisone on the metabolic indices of hexosamine-containing biopolymers in the stomach].
The experimental findings showed that hydrocortisone effect on metabolism of hexosamine-containing biopolymers of the stomach was dose-dependent. When administered in a small dose (0.2 mg/kg body weight) it increased the activity of biosynthesis of hexosamines, which are necessary for the formation of hexosamine-containing biopolymers, and also increased the total content in the gastric wall of biopolymers, glycosaminoglycans and glycoproteins soluble in perchloric acid. Administration of a large dose of the hormone (50 mg/kg) produced opposite changes in the studied tissue. In patients with peptic ulcer of the stomach and duodenum, exacerbation of which occurred against the background of stress-induced hypercorticosteroidemia, there was observed a decrease of glycosaminoglycan content in the gastric juice and mucosa. A decrease of hexosamine content in glycoproteins was noted.
Sharaev
P N
PN
Ivanov
V G
VG
Kutiavin
L I
LI
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000328:Adult; D000818:Animals; D001704:Biopolymers; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D006595:Hexosamines / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D051381:Rats; D013270:Stomach / Q000187:drug effects*; D013276:Stomach Ulcer / Q000188:drug therapy / Q000378:metabolism
D015062:11-Hydroxycorticosteroids; D001704:Biopolymers; D006023:Glycoproteins; D006025:Glycosaminoglycans; D006595:Hexosamines; D006854:Hydrocortisone
Izuchenie vliianiia gidrokortizona na pokazateli obmena geksozaminsoderzshchikh biopolimerov zheludka.