title: Technetium-99m HM-PAO-SPECT study of regional cerebral perfusion in early Alzheimer's disease.
abstract: Regional cerebral perfusion was evaluated by single photon emission computed tomography (SPECT) using technetium-99m hexamethylpropyleneamine oxime ([99mTc]HM-PAO) in sixteen patients with Alzheimer's disease (AD) in early clinical phase and in 16 healthy elderly controls. In all patients transmission computed tomography (TCT) and/or magnetic resonance imaging (MRI) did not show focal brain abnormalities. Relative to normal subjects, AD patients showed significant reductions in cortical/cerebellar activity ratio: cortical perfusion was globally depressed with the largest reductions in frontal and posterior temporo-parietal cortices. Asymmetries of relative perfusion between cerebral hemispheres were also demonstrated when language was affected or visuospatial functions were unevenly impaired. In patients with early AD, SPECT provides functional information to be compared with clinical and psychometric data.
authors.affiliation: Department of Biomedical Technologies, H. S. Raffaele, University of Milan, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Perani
authors.forename: V
authors.initials: V
authors.lastname: Di Piero
authors.forename: G
authors.initials: G
authors.lastname: Vallar
authors.forename: S
authors.initials: S
authors.lastname: Cappa
authors.forename: C
authors.initials: C
authors.lastname: Messa
authors.forename: G
authors.initials: G
authors.lastname: Bottini
authors.forename: A
authors.initials: A
authors.lastname: Berti
authors.forename: D
authors.initials: D
authors.lastname: Passafiume
authors.forename: G
authors.initials: G
authors.lastname: Scarlato
authors.forename: P
authors.initials: P
authors.lastname: Gerundini
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D001921:Brain / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D010091:Oximes; D013667:Technetium; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed
chemical_list: D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D013667:Technetium