title: Fetal oxygen uptake during uterine contractures.
abstract: During contractures there are decreases in fetal oxygen tension. In order to determine if there are concomitant changes in fetal oxygen consumption, we calculated the latter during contractures from measurements of the umbilical blood flow and venous arterial oxygen content differences across the umbilical circulation. There were decreases in both the umbilical venous (from 8.8 +/- 0.2 (SEM) to 8.5 +/- 0.2 ml.dl-1, P less than 0.01) and umbilical arterial (5.9 +/- 0.1 to 5.2 +/- 0.2 mg.dl-1, P less than 0.001) oxygen contents. The umbilical venous-arterial oxygen content difference increased from 2.9 +/- 0.1 to 3.3 +/- 0.2 ml.dl-1 (P less than 0.005). Umbilical blood flow was 194.3 +/- 4.5 ml.min-1 kg-1 during relaxation and was unchanged during contractures. Fetal oxygen uptake increased from 5.7 +/- 0.3 to 6.5 +/- 0.4 ml.min-1 kg-1 (P less than 0.005) during contractures. This observation is consistent with our previous speculation that there is increased muscular activity of tone associated with contractures.
authors.affiliation: Departamento de Preclinicas, Facultad de Medicina, Universidad de Chile, Santiago.
authors.forename: A J
authors.initials: AJ
authors.lastname: Llanos
authors.forename: B S
authors.initials: BS
authors.lastname: Block
authors.forename: D J
authors.initials: DJ
authors.lastname: Court
authors.forename: A M
authors.initials: AM
authors.lastname: Germain
authors.forename: J T
authors.initials: JT
authors.lastname: Parer
mesh_terms: D000818:Animals; D005260:Female; D005333:Fetus / Q000378:metabolism*; D010101:Oxygen Consumption; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D012756:Sheep / Q000378:metabolism*; D014590:Uterine Contraction