title: In vivo measurement of carbon-11 thymidine uptake in non-Hodgkin's lymphoma using positron emission tomography.
abstract: Carbon-11 thymidine (TdR) uptake using positron emission tomography (PET) has been measured in ten patients with non-Hodgkin's lymphoma (NHL). The rate of TdR uptake (mean +/- s.d.) was of 0.009 +/- 0.006 mumol.100 cc-1.min-1 in low-grade NHL. This rate was 0.063 +/- 0.049 mumol.100 cc-1.min-1 in intermediate-grade NHL and 0.159 mumol.100 cc-1.min-1 in a patient with high-grade NHL. Lymphoma radioactivity reached a plateau at 0.42 +/- 0.22%. 100 cc-1 of the injected dose from 10 min after injection. The highest 11C uptakes were observed in the kidneys and in the liver (3.30 +/- 1.30 and 2.10 +/- 0.05%. 100 cc-1 of the injected dose, respectively). The lymphoma-to-muscle ratio was of 11.8 +/- 1.7, whereas the lymphoma-to-intestine ratio was of 1.5 +/- 0.7. Accordingly, the measurement of [11C]TdR uptake in the abdomen may need other imaging methods for adequate interpretation. The results suggest that [11C]TdR uptake using PET might be a method for noninvasively measuring cell proliferation in vivo.
authors.affiliation: Department of Hematology, University of Louvain, Medical School, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Martiat
authors.forename: A
authors.initials: A
authors.lastname: Ferrant
authors.forename: D
authors.initials: D
authors.lastname: Labar
authors.forename: M
authors.initials: M
authors.lastname: Cogneau
authors.forename: A
authors.initials: A
authors.lastname: Bol
authors.forename: C
authors.initials: C
authors.lastname: Michel
authors.forename: J L
authors.initials: JL
authors.lastname: Michaux
authors.forename: G
authors.initials: G
authors.lastname: Sokal
mesh_terms: D002250:Carbon Radioisotopes; D002455:Cell Division; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging*; D013936:Thymidine; D013997:Time Factors; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D013936:Thymidine