title: MIBG and catecholamine storage in the brain: an in-vitro study.
abstract: The uptake and release of mIBG, a tracer of the monoamine uptake and storage function, were studied on superfused rat cerebral cortex sections. mIBG was taken up and released by a mechanism comparable to that of norepinephrine (NE), but this storage appeared to be less specific for mIBG than for NE. This implies that when mIBG is used as a scintigraphic tracer of monoaminergic synaptic vesicles, imaging should be delayed long enough to ensure release of the molecule from its nonspecific binding sites.
authors.affiliation: Unité INSERM U316, Laboratoire de Biophysique Médicale, U.E.R. de Médecine, Tours, France.
authors.forename: D
authors.initials: D
authors.lastname: Guilloteau
authors.forename: F
authors.initials: F
authors.lastname: Huguet
authors.forename: S
authors.initials: S
authors.lastname: Chalon
authors.forename: J L
authors.initials: JL
authors.lastname: Baulieu
authors.forename: P
authors.initials: P
authors.lastname: Gerard
authors.forename: G
authors.initials: G
authors.lastname: Narcisse
authors.forename: L
authors.initials: L
authors.lastname: Pourcelot
authors.forename: J C
authors.initials: JC
authors.lastname: Besnard
mesh_terms: D019797:3-Iodobenzylguanidine; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000493:pharmacokinetics*; D009638:Norepinephrine / Q000493:pharmacokinetics*; D051381:Rats; D014316:Tritium
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D014316:Tritium; D019797:3-Iodobenzylguanidine; D009638:Norepinephrine