title: [Clinico-biochemical parallels against a background of traditional treatment and laser therapy of patients with ischemic heart disease].
abstract: The paper is devoted to analysis of clinico-biochemical indices and a quest for additional pathologico-chemical criteria at the cell membrane level of the efficacy of helium-neon laser therapy in coronary heart disease (CHD). Another task was to decipher a number of metabolic signs of the phenomenon of CHD "exacerbation" in laser therapy (during 4-6 sessions). Positive clinical results were obtained in 98% of the patients. A favorable time course was noted in serum lipoprotein spectrum indices and in lipid and phospholipid structure of erythrocyte membranes. Laser therapy caused mobilization of the cell membrane antioxidant defense. The 4th-6th session of irradiation was marked by temporary clinical deterioration--"exacerbation" of disease accompanied by an increase in the level of erythrocyte total phospholipids (at the expense of PTEA), a decrease in free fatty acid deficiency against a background of advancing alpha-tocopherol deficiency and a rise of the blood level of lipid peroxidation primary products (diene conjugates). A conclusion was that membrane protective drugs and drugs enhancing cell energy and antioxidant defense resources promoting the "deactivation" of influence on the membrane of lipid peroxidation metabolites (tocopherol, Essentiale, retinol, etc.) should be incorporated in therapy of CHD in order to prevent the phenomenon of its "exacerbation".
authors.forename: I M
authors.initials: IM
authors.lastname: Korochkin
authors.forename: A V
authors.initials: AV
authors.lastname: Kartelishev
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Leshakov
authors.forename: G M
authors.initials: GM
authors.lastname: Kapustina
authors.forename: N S
authors.initials: NS
authors.lastname: Vernekina
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000097:blood* / Q000628:therapy; D004910:Erythrocyte Membrane / Q000378:metabolism / Q000528:radiation effects; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D053685:Laser Therapy; D015227:Lipid Peroxidation / Q000528:radiation effects; D008055:Lipids / Q000097:blood / Q000528:radiation effects; D008074:Lipoproteins / Q000097:blood / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood / Q000528:radiation effects; D012074:Remission Induction; D014810:Vitamin E / Q000097:blood / Q000528:radiation effects
chemical_list: D008055:Lipids; D008074:Lipoproteins; D010743:Phospholipids; D014810:Vitamin E
vernacular_title: Kliniko-biokhimicheskie paralleli na fone traditsionnogo lecheniia i lazeroterapii bol'nykh ishemicheskoĭ bolezn'iu serdtsa.