title: Nonsteroidal antiinflammatory agents. XVIII - Stereomeric optically active halogenophenyl-biphenylyl-hydroxypropionic acids.
abstract: The optically active stereomers of some 3-(fluoro-, chloro-, bromophenyl)-2-biphenylyl-3-hydroxypropionic acids were prepared and tested for antiinflammatory activity. Surprisingly, the four bromo-isomers were the most active ones, particularly in the threo configuration.
authors.affiliation: Departimento di Scienze Farmaceutiche Università di Bologna, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Varoli
authors.forename: S
authors.initials: S
authors.lastname: Burnelli
authors.forename: A
authors.initials: A
authors.lastname: Guarnieri
authors.forename: N
authors.initials: N
authors.lastname: Ghedini
authors.forename: G
authors.initials: G
authors.lastname: Scapini
authors.forename: S
authors.initials: S
authors.lastname: Ferri
authors.forename: E
authors.initials: E
authors.lastname: Cavicchini
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004487:Edema / Q000188:drug therapy; D010666:Phenylpropionates / Q000627:therapeutic use; D013237:Stereoisomerism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates