Cancer-induced alterations in T-cell subsets in normal and cyclophosphamide-treated mice. A flow cytometric analysis.
The influence of an ascites carcinoma on splenic T-cell subsets in normal or cyclophosphamide (Cy)-pretreated mice immunized with sheep erythrocytes was determined by immunophenotypic analysis, using an 'EPICS C' flow cytometer. As suggested by our previous studies on lymphokine production, the results obtained were consistent with direct impairment of Th-cell function and/or with tumour-induced suppression of cell-mediated immunity by Cy-insensitive suppressor cells, such as the 'Ts effector' (Ts3) or those of non-T-cell lineage.
Tonner
E
E
Department of Pathology, University of Aberdeen, UK.
Sewell
H F
HF
Thomson
A W
AW
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D005434:Flow Cytometry; D007111:Immunity, Cellular; D051379:Mice; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification*; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000276:immunology
D003520:Cyclophosphamide