title: [Vasculo-thrombocyte hemostasis in arterial hypertension].
abstract: The components of the vascular-thrombocyte hemostasis were studied in two models of arterial hypertension: the genetically determined spontaneous (SAH) hypertension and the acute renovascular one (RAH). The reactivity of thrombocytes to the aggregation inductors was increased in hypertensive rats. Disaggregation was considerably accelerated in RAH which led to a shortening of the aggregation response. The contents of serotonin free adenine nucleotides and glycogen were decreased in the thrombocyte of hypertensive rats, the serotonin exchange was altered and the aorta antiaggregation activity was enhanced. The model of laser-induced thrombosis revealed an enhancement of thrombogenesis and a reduction of thromboresistance of the vessels in SAH. The prevalence of the thrombogenesis in vessels seems to be a potentiating factor for thrombosis in hypertension.
authors.forename: N N
authors.initials: NN
authors.lastname: Petrishchev
authors.forename: S A
authors.initials: SA
authors.lastname: Shestakova
mesh_terms: D000227:Adenine Nucleotides / Q000097:blood; D000244:Adenosine Diphosphate / Q000502:physiology; D000818:Animals; D001011:Aorta / Q000503:physiopathology; D006003:Glycogen / Q000097:blood; D006487:Hemostasis; D007834:Lasers / Q000009:adverse effects; D008833:Microcirculation; D010974:Platelet Aggregation; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012701:Serotonin / Q000097:blood; D013917:Thrombin / Q000502:physiology; D013927:Thrombosis / Q000503:physiopathology
chemical_list: D000227:Adenine Nucleotides; D012701:Serotonin; D000244:Adenosine Diphosphate; D006003:Glycogen; D013917:Thrombin
vernacular_title: Sosudisto-trombotsitarnyĭ gemostaz pri arterial'noĭ gipertenzii.