title: Sjögren's syndrome: a study of its neurological complications.
abstract: A detailed retrospective study of 105 patients with Sjögren's syndrome (50 primary and 55 secondary cases), showed that 31 had vasculitis and 18 had neurological abnormalities which after full investigation were not attributable to other causes. Most of the neurological symptoms were mild and when found in patients with secondary Sjögren's syndrome were more characteristic of the underlying autoimmune rheumatic disease. We found no significant association between the frequency of either vasculitis or any autoantibodies and the presence of neurological disease, but did confirm a significant association between vasculitis and the presence of antibodies to extractable nuclear antigens. We therefore question whether severe and relapsing neurological disease is common in patients with Sjögren's syndrome.
authors.affiliation: Bloomsbury Rheumatology Department, University College, London.
authors.forename: A
authors.initials: A
authors.lastname: Binder
authors.forename: M L
authors.initials: ML
authors.lastname: Snaith
authors.forename: D
authors.initials: D
authors.lastname: Isenberg
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis; D002349:Carpal Tunnel Syndrome / Q000209:etiology; D006801:Humans; D002546:Ischemic Attack, Transient / Q000209:etiology; D009422:Nervous System Diseases / Q000209:etiology*; D012217:Rheumatoid Factor / Q000032:analysis; D012859:Sjogren's Syndrome / Q000150:complications* / Q000276:immunology; D013223:Statistics as Topic; D014277:Trigeminal Neuralgia / Q000209:etiology
chemical_list: D000974:Antibodies, Antinuclear; D012217:Rheumatoid Factor