An investigation of the metabolism of S-carboxymethyl-L-cysteine in man using a novel HPLC-ECD method.
The metabolism of an oral dose of S-carboxymethyl-L-cysteine (SCMC) in man has been studied; the quantitative determination of SCMC, S-methyl-L-cysteine (SMC) and their sulphoxide metabolites (SCMCO and SMCO), in urine, was carried out using high performance liquid chromatography (HPLC) with electrochemical detection (ECD); the possibility of stereospecific sulphoxidation was investigated.
Karim
E F
EF
Department of Pharmacy, Queen's University of Belfast, Northern Ireland.
Millership
J S
JS
Temple
D J
DJ
Woolfson
A D
AD
D002233:Carbocysteine / Q000032:analysis / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003545:Cysteine / Q000031:analogs & derivatives* / Q000032:analysis; D006801:Humans; D008297:Male; D013454:Sulfoxides / Q000032:analysis
D013454:Sulfoxides; D002233:Carbocysteine; C008425:S-methylcysteine; D003545:Cysteine