Relationship between parathyroid hormone and pituitary-testicular axis in patients on maintenance hemodialysis.
The effect of secondary hyperparathyroidism upon hormones of the pituitary testicular axis was studied in 39 end-stage kidney disease male patients on maintenance hemodialysis. In hemodialysed patients the mean serum levels of PTH, prolactin and LH were significantly increased, that of testosterone decreased, and of FSH unchanged. PTH and prolactin values were found to be dependent upon residual renal function measured by 24 h urine output. A significant positive correlation was found between the serum levels of PTH and LH (r = 0.405) and between PTH and serum levels of prolactin (r = 0.401). Secondary hyperparathyroidism is suggested to be responsible, at least partly, for sexual dysfunction in male patients on maintenance hemodialysis.
Bogićević
M
M
Institute of Nephrology and Hemodialysis, Faculty of Medicine, Nis/Yugoslavia.
Stefanović
V
V
D000293:Adolescent; D000328:Adult; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications / Q000209:etiology / Q000503:physiopathology; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010902:Pituitary Gland / Q000378:metabolism / Q000503:physiopathology; D006435:Renal Dialysis / Q000009:adverse effects; D012735:Sexual Dysfunction, Physiological / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D013737:Testis / Q000378:metabolism / Q000503:physiopathology; D013739:Testosterone / Q000097:blood
D006065:Gonadotropins, Pituitary; D010281:Parathyroid Hormone; D013739:Testosterone