Acute monoblastic leukemia with osteosclerosis and extensive myelofibrosis.
A 4-month-old infant was admitted with a monoblastic infiltration of the skin associated with osteosclerosis. Both lesions spontaneously disappeared within a few months, but 2 years later, a monoblastic leukemia occurred that was associated with marked skin erythema and myelofibrosis. Skin and bone marrow specimens showed a monoblastic infiltration with numerous intermingled mast cells of normal appearance. Whether myelofibrosis was a feature of a systemic mastocytosis or of the leukemic process is discussed in this case.
Janin
A
A
Department of Pathology, Hôpital Calmette, Lille, France.
Nelken
B
B
Dufour
S
S
Sault
M C
MC
Taboureau
O
O
Zandecki
M
M
Gosselin
B
B
D006801:Humans; D007223:Infant; D007948:Leukemia, Monocytic, Acute / Q000473:pathology*; D008297:Male; D009365:Neoplasm Regression, Spontaneous; D010026:Osteosclerosis / Q000209:etiology*; D055728:Primary Myelofibrosis / Q000209:etiology*