title: Malignant pituitary tumors.
abstract: Pituitary malignancies are rare. The definition of pituitary malignancy is still subject to debate. Three types of malignancy with the description of clinical course and complete autopsy were presented; i) true carcinosarcoma, ii) ectopic sphenoid invasive tumor, and iii) post-irradiation sarcoma. The first true carcinosarcoma had a long natural tumor history of 46 years, ending in malignant transformation with extracranial metastasis from a pituitary adenoma. The second ectopic sphenoid tumor was prolactin-producing, locally invasive, with the intact pituitary gland. The third post-irradiation sarcoma was followed by chromophobe pituitary adenoma. The interval between irradiation to the adenoma and malignant transformation to fibrosarcoma was about 14 years.
authors.affiliation: Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kameya
mesh_terms: D000236:Adenoma / Q000473:pathology* / Q000532:radiotherapy; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D010911:Pituitary Neoplasms / Q000201:enzymology / Q000473:pathology* / Q000532:radiotherapy; D015175:Prolactinoma / Q000473:pathology*
chemical_list: D010751:Phosphopyruvate Hydratase