Cardiovascular function and arterial blood gases during sham dialysis in healthy man.
Cardiovascular function and alveolar gas exchange were studied in healthy subjects undergoing sham dialysis (SHD)--i.e. the circulation of blood through a cuprophane dialyzer with the dialysate compartment closed to avoid diffusion and convective transport of fluid and solutes. The blood-membrane contact induced complement activation (rise in C3d) and transient leukopenia, as described during clinical hemodialysis. PaO2, PaCO2 and calculated oxygen uptake remained unchanged. Heart rate, cardiac index (thermodilution), systemic vascular resistance index and brachial and pulmonary arterial blood pressures did not change significantly during 150 min of SHD (n = 8). In 12 subjects, in whom more frequent measurements were made during the first 30 min of SHD, pulmonary arterial systolic and diastolic blood pressures decreased significantly while the dialyzer and the tubing set filled with blood, and pulmonary arterial mean blood pressure did not change significantly. Pulmonary capillary wedge pressure fell during the filling phase, but did not change significantly during SHD; pulmonary vascular resistance index remained unchanged. We conclude that in nonuremic subjects sham dialysis with a cuprophane dialyzer does not result in hypoxemia, pulmonary vascular constriction and pulmonary hypertension, in spite of complement activation and marked leukopenia.
Danielsson
A
A
Department of Renal Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Freyschuss
U
U
Bergström
J
J
D000136:Acid-Base Equilibrium; D000328:Adult; D002482:Cellulose / Q000031:analogs & derivatives; D003176:Complement C3 / Q000378:metabolism; D015933:Complement C3d; D006439:Hemodynamics; D006801:Humans; D008297:Male; D011659:Pulmonary Gas Exchange; D006435:Renal Dialysis / Q000295:instrumentation
D003176:Complement C3; D015933:Complement C3d; D002482:Cellulose; C009865:cuprammonium cellulose