title: The use of [99mTc]-HM-PAO in the diagnosis of primary degenerative dementia.
abstract: The clinical value of single photon emission computed tomography (SPECT) in the differential diagnosis of dementia due to cerebral atrophy was evaluated by comparing the pattern of distribution [99mTc]-HM-PAO in three dementing conditions. Imaging was carried out in 26 patients with suspected Alzheimer's disease, 14 with dementia of the frontal-lobe type, and 13 with progressive supranuclear palsy. Images were evaluated and reported without knowledge of clinical diagnosis with respect to regions of reduced uptake of tracer. Reduced uptake in the posterior cerebral hemispheres was characteristic of Alzheimer's disease, while selective anterior hemisphere abnormalities characterized both dementia of the frontal-lobe type and progressive supranuclear palsy. The latter conditions could be distinguished on the basis of the appearance of integrity of the rim of the frontal cortex. The technique has an important role in the differentiation of degenerative dementias.
authors.affiliation: Department of Nuclear Medicine, Manchester Royal Infirmary, England.
authors.forename: H J
authors.initials: HJ
authors.lastname: Testa
authors.forename: J S
authors.initials: JS
authors.lastname: Snowden
authors.forename: D
authors.initials: D
authors.lastname: Neary
authors.forename: R A
authors.initials: RA
authors.lastname: Shields
authors.forename: A W
authors.initials: AW
authors.lastname: Burjan
authors.forename: M C
authors.initials: MC
authors.lastname: Prescott
authors.forename: B
authors.initials: B
authors.lastname: Northen
authors.forename: P
authors.initials: P
authors.lastname: Goulding
mesh_terms: D000368:Aged; D001284:Atrophy; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D003704:Dementia / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D010091:Oximes; D013667:Technetium; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed
chemical_list: D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D013667:Technetium