title: [Spatial-temporal organization of the deep cortex of the lymph node].
abstract: In various areas of the deep cortex: central and peripheral parts, as well as T-territory (adjoining the fundus of the germinative center) various cells (small and middle lymphocytes, immunoblasts, plasmoblasts, immature and mature plasma cells and mitotically dividing cells) have been counted. The population density of various immunocompetent cells differs significantly in various areas of the deep cortex. Immunoblasts predominate in the center, cells of the plasmic line--in the periphery of the deep cortex and in the T-territory. Fluctuations of the population density are time-dependent. Spectral composition and parameters of rhythmicity for each cellular type and general course of the process are estimated. In the spectral composition ultradian components predominate. The circadian components are more specific for T- than for B-dependent zone. For immunoblasts in all the zones a common period of fluctuations, nearly 10 h, is revealed, and for the cells of the plasmic line 7 hours' period is common; therefore, it is possible to suppose presence of synchronizing pace-makers of the rhythm for T-lymphocytes, on the one hand, and for antibody-forming cells, on the other hand. Spectral composition of rhythmicity of the cells in the T-territory and in other part of the deep cortex has a number of similar components, that demonstrates functional unity of these zones. A higher part of the cells of the plasmic line in the T-territory and in the periphery of the deep cortex is, perhaps, connected with their migration along these areas towards medullar cords. The general process is of a complex character, rises and drops are registered at various time of the day.
authors.forename: T S
authors.initials: TS
authors.lastname: Smirnova
authors.forename: L V
authors.initials: LV
authors.lastname: Ermolina
mesh_terms: D000818:Animals; D002452:Cell Count; D002455:Cell Division; D002940:Circadian Rhythm; D008198:Lymph Nodes / Q000033:anatomy & histology* / Q000166:cytology; D008297:Male; D051379:Mice
vernacular_title: Prostranstvenno-vremennaia organizatsiia glubokoĭ kory limfaticheskogo uzla.