Amine fluorescence histochemical investigation of the striatum in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced parkinsonian mice.
Treatment of mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) markedly decreased dopamine fluorescence in the lateral part of the striatum but not in the median part of the striatum. However, dopamine fluorescence in lateral part of the striatum recovered by treatment L-dihydroxyphenylalanine(L-DOPA).
Mizukawa
K
K
Department of Anatomy, Okayama University Medical School, Japan.
Ogawa
N
N
Sora
Y H
YH
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D006651:Histocytochemistry; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008856:Microscopy, Fluorescence; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000378:metabolism*; D011725:Pyridines
D011725:Pyridines; D007980:Levodopa; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine