Sodium dependence of amino acid-stimulated acid secretion in the conscious rat.
Gastric acid secretion in conscious gastric-fistulated rats was measured by non-recirculating constant gastric perfusion, and extragastric autotitration. Luminal L-amino acids stimulated acid secretion with a potency histidine greater than alanine greater than tryptophan. The response to histidine was concentration dependent, and was inhibited by low pH and by low luminal sodium. These results are consistent with the idea that a sodium-dependent uptake mechanism might, in part, mediate the acid secretory response to intragastric amino acids.
Martin
V
V
Physiological Laboratory, University of Liverpool.
Dimaline
R
R
D000409:Alanine / Q000494:pharmacology; D000596:Amino Acids / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001693:Biological Transport, Active; D005744:Gastric Acid / Q000378:metabolism*; D006639:Histidine / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*; D014364:Tryptophan / Q000494:pharmacology
D000596:Amino Acids; D006639:Histidine; D014364:Tryptophan; D012964:Sodium; D000409:Alanine