The effect of naftidrofuryl on PGF2 alpha, U 46.619, 5-HT and thromboxane A2 (TXA2) induced vasoconstriction.
This study was designed to investigate the effects of Naftidrofuryl on platelet function and vessel tone and additionally platelet vessel wall interactions. It is shown that Naftidrofuryl displays a spasmolytic activity against a variety of different vasoconstrictors, including 5-HT, PGF2 alpha, U 46.619 and KC1 and inhibits platelet secretion. These effects are observed at concentrations of the compound equal to or higher than 1 mumol/l and might contribute to the clinical efficacy of the drug.
Verheggen
R
R
Neurochirurgische Klinik, Universität Göttingen, FRG.
Schrör
K
K
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000818:Animals; D002417:Cattle; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology; D015237:Dinoprost / Q000494:pharmacology*; D005663:Furans / Q000494:pharmacology*; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D009257:Nafronyl / Q000494:pharmacology*; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology*; D013928:Thromboxane A2 / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*
D005663:Furans; D011450:Prostaglandin Endoperoxides, Synthetic; D012701:Serotonin; D009257:Nafronyl; D013928:Thromboxane A2; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D015237:Dinoprost