Localized epileptiform activity induced by murine CRF in rats.
Murine corticotropin releasing factor (rCRF), injected intracerebroventricularly into rats at a dose of 10 micrograms produced increased motor activity, grooming, and recurrent episodes of epileptic activity localized in the hippocampal leads. Such activity persisted for approximately 5 h and was characterized by recurrent trains of biphasic spikes never associated with behavioral signs of epilepsy. The intraperitoneal administration of carbamazepine (15 and 30 mg/kg) reduced the epileptic activity for approximately 90 and 120 min, respectively, whereas that of naloxone (8 mg/kg) was ineffective. The results suggest that rCRF-induced spiking activity might be a model of temporal lobe epilepsy.
Marrosu
F
F
Institute of Neurology, University of Cagliari, Italy.
Fratta
W
W
Carcangiu
P
P
Giagheddu
M
M
Gessa
G L
GL
D000818:Animals; D001921:Brain / Q000503:physiopathology; D003346:Corticotropin-Releasing Hormone; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D008959:Models, Neurological; D051381:Rats; D011919:Rats, Inbred Strains
D003346:Corticotropin-Releasing Hormone