Detection of linkage between a quantitative trait and a marker locus by the lod score method: sample size and sampling considerations.
A simulation study is here conducted to measure the power of the lod score method to detect linkage between a quantitative trait and a marker locus in various situations. The number of families necessary to detect such linkage with 80% power is assessed for different sets of parameters at the trait locus and different values of the recombination fraction. The effects of varying the mode of sampling families and the sibship size are also evaluated.
Demenais
F
F
Unité de Recherches de Génétique Epidémiologique, I.N.S.E.R.M. U.155, Château de Longchamp, Bois de Boulogne, Paris, France.
Lathrop
G M
GM
Lalouel
J M
JM
D003198:Computer Simulation; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D009679:Nuclear Family; D012494:Sampling Studies
D005819:Genetic Markers