The CNS effects of 5-aminobenzoic acids inhibiting the biosynthesis of prostaglandins.
It was found that the 2,5-diaminobenzoic acid derivatives 1 activating the biosynthesis of prostaglandins have CNS side effects. The replacement of the 2-NH group in 1 by O or S resulted an inhibition of prostaglandin biosynthesis and increased CNS activity.
Kosáry
J
J
Institute for Drug Research, Budapest, Hungary.
Kovács-Szabó
I
I
Király
I
I
Kasztreiner
E
E
D062365:Aminobenzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D002492:Central Nervous System Depressants / Q000138:chemical synthesis*; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011453:Prostaglandins / Q000096:biosynthesis*; D013055:Spectrophotometry, Infrared
D062365:Aminobenzoates; D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D011453:Prostaglandins