[Selection for a decrease in metastatic potential in a cell population of transplantable rat rhabdomyosarcoma RA-2].
The method of individual cloning was used for checking the reduction of metastatic potential (MP) in cell population of highly malignant rhabdomyosarcoma RA-2. In the course of 15 selection cycles MP was lowered by 10-15 times. These data enabled us to consider the MP value as a quantitative character of malignant cells with low heritability (the mean value of realized heritability coefficient is equal to 0.18).
Guzhova
I V
IV
Vakhtin
Iu B
IuB
D000818:Animals; D002999:Clone Cells / Q000166:cytology; D008175:Lung Neoplasms / Q000473:pathology*; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D051381:Rats; D012208:Rhabdomyosarcoma / Q000473:pathology*; D012641:Selection, Genetic; D014407:Tumor Cells, Cultured
Otbor na snizhenie metastaticheskogo potentsiala v populiatsii kletok perevivnoĭ rabdomiosarkomy PA-2 krys.