Calcium dobesilate and its effects on hemorheology and microcirculation.
In series, 50 patients suffering from cerebral (n = 33) and peripheral (n = 17) diseases were treated with 3 x 500 mg calcium dobesilate (Doxium) per day. Before onset of therapy and after 14 days the viscoelasticity of whole blood and plasma as well as hematocrit and microcirculation at the finger pad were measured. Viscoelasticity of whole blood, plasma and hematocrit decreased in a significant manner (p less than or equal to 0.001), while microcirculation increased significantly (p less than or equal to 0.001). The results justify the application of calciumdobesilate for ischemic diseases with elevated viscosity.
Költringer
P
P
Hospital of the Barmherzige Brüder at Graz-Eggenberg, Austria.
Eber
O
O
Rothlauer
W
W
Klima
G
G
Lind
P
P
Langsteger
W
W
Wakonig
P
P
D000328:Adult; D000368:Aged; D001557:Benzenesulfonates / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects*; D002123:Calcium Dobesilate / Q000494:pharmacology*; D005260:Female; D006400:Hematocrit; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D008875:Middle Aged
D001557:Benzenesulfonates; D002123:Calcium Dobesilate