title: Current therapeutic possibilities of GIFT.
abstract: We have used GIFT in 74 couples affected with unexplained sterility, male hypofertility, endometriosis, phymosis of the fimbria and adhesions impeding oocyte pick-up. We systematically desensitized the pituitary using a GnRH analog from the 20th day of the cycle preceding GIFT. All the patients were hyperstimulated with purified FSH and hMG (Metrodin and Pergonal-Serono) from the 3rd day of the cycle. When several follicles were obtained woth a diameter greater than 16 mm together with serum estradiol values of 300 pg/ml per follicle, 10,000 IU hCG were administered intramuscularly in a single dose (Profasi-Serono). A maximum of 5 oocytes per patient were transferred (2-3 per tube). Our results confirm the validity of the GIFT method, with an average success rate of 19% in all pathological conditions and a far greater success rate in couples with unexplained sterility than in those with male hypofertility (31% and 10% respectively). The Authors stress that the best results of GIFT were achieved when the ratio between E2 and follicles with a diameter greater than 16 mm was in excess of 500 pg/ml.
authors.affiliation: Istituto di Clinica Ostetrica e Ginecologica, Università Cattolica del Sacro Cuore, Roma.
authors.forename: N
authors.initials: N
authors.lastname: Garcea
authors.forename: S
authors.initials: S
authors.lastname: Campo
authors.forename: R
authors.initials: R
authors.lastname: Dargenio
authors.forename: P
authors.initials: P
authors.lastname: Cannella
authors.forename: L
authors.initials: L
authors.lastname: Iaconianni
authors.forename: G
authors.initials: G
authors.lastname: Bonavolontà
authors.forename: S
authors.initials: S
authors.lastname: Mancuso
mesh_terms: D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D015181:Gamete Intrafallopian Transfer; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000628:therapy*; D008297:Male; D010062:Ovulation Induction / Q000379:methods
chemical_list: D004958:Estradiol