title: Optical and nuclear magnetic resonance studies of hypoxia in human tissue and tumors.
abstract: Correlations of energy state with response to therapy are more difficult to analyze because of the large effect of tumor clearing and oxygenation upon the tumor energy state as detected by PMRS alone. The combination of time-resolved hemoglobinometry using picosecond laser technology and localized PMRS seems appropriate to unravel the complexities of therapeutic intervention, tumor energetics, and oxygenation.
authors.affiliation: Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104.
authors.forename: B
authors.initials: B
authors.lastname: Chance
authors.forename: E
authors.initials: E
authors.lastname: Borer
authors.forename: A
authors.initials: A
authors.lastname: Evans
authors.forename: G
authors.initials: G
authors.lastname: Holtom
authors.forename: J
authors.initials: J
authors.lastname: Kent
authors.forename: M
authors.initials: M
authors.lastname: Maris
authors.forename: K
authors.initials: K
authors.lastname: McCully
authors.forename: J
authors.initials: J
authors.lastname: Northrop
authors.forename: M
authors.initials: M
authors.lastname: Shinkwin
mesh_terms: D004734:Energy Metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*
chemical_list: D010100:Oxygen