title: [EGF receptors (epidermal growth factor) and steroid receptors in human meningioma].
abstract: Epidermal growth factor receptor (EGF-R) were assayed by 125I-EGF binding in 28 surgical samples of human meningiomas. High affinity EGF-R were found in 26/28 tumors (92 p. 100) at concentrations ranging from 20 to 410 femtomoles per mg of membrane protein (fmol/mg prot. mb.). In 18/26 cases (64 p. 100), the EGF-R concentration was between 95 and 230 fmol/mg prot. mb. No relationship was found between the EGF-R level and the site or histopathology of the tumor. The only noticeable observations were the low levels of EGF-R in the 3 anaplasic meningiomas as compared to the whole population and the undetectable level of EGF-R in the angiomatous tumors. In addition, no correlation was found between EGF-R levels and the hormonal status of the patients, nor between EGF-R levels and the intratumoral concentration of progesterone receptors assayed simultaneously. The biological relevance of EGF-R in meningioma is discussed in this context.
authors.affiliation: Laboratoire de Radiopathologie, Institut Curie, Paris.
authors.forename: M
authors.initials: M
authors.lastname: Grimaux
authors.forename: H
authors.initials: H
authors.lastname: Magdelenat
authors.forename: M
authors.initials: M
authors.lastname: Poisson
authors.forename: J M
authors.initials: JM
authors.lastname: Chamouard
authors.forename: D
authors.initials: D
authors.lastname: Barritault
authors.forename: J F
authors.initials: JF
authors.lastname: Foncin
authors.forename: J
authors.initials: J
authors.lastname: Philippon
mesh_terms: D000328:Adult; D000368:Aged; D004815:Epidermal Growth Factor / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008579:Meningioma / Q000378:metabolism* / Q000473:pathology; D008593:Menopause; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism*
chemical_list: D007457:Iodine Radioisotopes; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid; D004815:Epidermal Growth Factor; D066246:ErbB Receptors
vernacular_title: Récepteurs d'EGF (epidermal growth factor) et de stéroïdes dans les méningiomes humains.