Antibody producing ability of mouse spleen cells after subacute dietary exposure to T-2 toxin.
The effects of T-2 toxin on the antibody producing ability of CD-1 mice after dietary exposure to 0, 2.5, 5 and 15 ppm of T-2 toxin for 29 days was studied. The antibody response against sheep red blood cells, a T-lymphocyte and macrophage-dependent response was suppressed at 2.5, 5 and 15 ppm of T-2 toxin exposure. In contrast, the antibody responses against dinitrophenyl-aminoethylcarbamylmethyl - Ficoll (DNP - Ficoll), a T-lymphocyte independent macrophage-dependent response, and Escherichia coli 0127 (LPS), a T-lymphocyte and macrophage-independent response, were not affected. These results suggest that the inhibitory effects of T-2 toxin on antibody-producing ability after subacute dietary exposure appear to be a direct affect on T-lymphocyte function, possibly involving the T-helper lymphocytes.
Tomar
R S
RS
Department of Veterinary Physiological Sciences, University of Saskatchewan, Saskatoon, Canada.
Blakley
B R
BR
DeCoteau
W E
WE
D000818:Animals; D000917:Antibody Formation; D000955:Antigens, T-Independent / Q000276:immunology; D001835:Body Weight; D004032:Diet; D004140:Dinitrophenols / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012717:Sesquiterpenes / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D013605:T-2 Toxin / Q000008:administration & dosage / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000955:Antigens, T-Independent; D004140:Dinitrophenols; D012717:Sesquiterpenes; D013605:T-2 Toxin