[T- and B-cell double lymphoma: immunologic characterization using monoclonal antibodies].
The coexistence of two non-Hodgkin lymphomas in one patient is extremely rare. We describe a patient who suffered for 17 years from chronic lymphocytic leukemia of B-cell origin with bone marrow and peripheral blood involvement until he developed clinically typical mycosis fungoides of the skin. The neoplastic lymphatic cells in the skin infiltrates were T-cells of the helper/inducer phenotype and thus differed morphologically and by immunological markers from the neoplastic cells in peripheral blood and bone marrow. The clonal B-cell expansion was controlled well over many years by cytotoxic drug therapy, the cutaneous T-cell lymphoma only with limited success by oral photochemotherapy owing to lack of compliance. The patient died 3 years after the diagnosis of MF from a parallel exacerbation of both diseases. Extensive immunohistochemical studies verified the nature of both lymphomas in vivo and at autopsy.
Aberer
W
W
I Universitäts-Hauklinik Wien.
Groh
V
V
Bettelheim
P
P
Radaszkiewicz
T
T
Wolff
K
K
D000368:Aged; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*; D013601:T-Lymphocytes
D000911:Antibodies, Monoclonal
T- und B-Zell-Doppellymphom: immunologische Charakterisierung mittels monoklonaler Antikörper.