Synthesis and pharmacological properties of derivatives of isoxazolo [5,4-d]-6,7-dihydropyrimidines.
The synthesis of 4-hydroxy-4-amino substituted 5-phenylisoxazolo [5,4-d]-6,7-dihydropyrimidines was described. The compounds with alkylamine and semicarbazide substituents in position 4 showed the activity against sarcoma Sa-180, while those with heterocyclic substituents at the same position have analgesic properties.
Machoń
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Z
Department of Organic Chemistry, Medical Academy, Wrocław, Poland.
Ryng
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D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D010080:Oxazoles / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D012510:Sarcoma 180 / Q000188:drug therapy
D000700:Analgesics; D000970:Antineoplastic Agents; D007555:Isoxazoles; D010080:Oxazoles; D011743:Pyrimidines