Synthesis and photobiological activity of new N,N-disubstituted 4-amino-3-chloroangelicins.
The synthesis of a series of new N,N-disubstituted 4-amino-3-chloroangelicins (4-amino-3-chloro-2H-furo[2,3-h]-1-benzopyran-2-ones) starting from N,N-disubstituted (E)-5-aminomethylene-6,7-dihydrobenzo[b]furan-4(5H)-ones is described. Their capacity of inhibiting DNA synthesis in Ehrlich ascites tumor cells by U.V.-A light irradiation as well as their phototoxic activity on guinea-pig skin have been studied and the data computed by probit analysis; the results are discussed in the light of the modifications introduced in the molecular structure.
Mosti
L
L
Istituto di Scienze Farmaceutiche, Università di Genova, Italy.
Menozzi
G
G
Schenone
P
P
Carlassare
F
F
Baccichetti
F
F
Bordin
F
F
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D004273:DNA, Neoplasm / Q000096:biosynthesis; D011564:Furocoumarins / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D051379:Mice; D010778:Photochemotherapy
D004273:DNA, Neoplasm; D011564:Furocoumarins