Antihypertensive efficacy of low dose torasemide in essential hypertension: a placebo-controlled study.
The blood pressure lowering effect of chronic treatment with the low, non-diuretic dose of 2.5 mg of torasemide, a new loop-diuretic, was assessed in 20 patients with mild to moderate essential hypertension (WHO stage I-II) in a randomised, double-blind, balanced, placebo-controlled, cross-over study. Blood pressure was significantly reduced after four weeks of torasemide as compared to four weeks of placebo. No significant diuretic effect was detected and there were no relevant metabolic or clinical side effects. The present results show that torasemide 2.5 mg once daily has a significant BP lowering effect and is well tolerated in patients with mild to moderate hypertension. This low dose, lacking significant diuretic activity, appears to be the recommended dose for starting antihypertensive treatment with this compound.
Dupont
A G
AG
Department of Pharmacology, University Hospital, Vrije Universiteit Brussel, Belgium.
Schoors
D
D
Six
R O
RO
Vanhaelst
L
L
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D001835:Body Weight; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010919:Placebos; D013449:Sulfonamides / Q000627:therapeutic use*; D000077786:Torsemide
D000959:Antihypertensive Agents; D010919:Placebos; D013449:Sulfonamides; D000077786:Torsemide