[Vitamin D deficiency and its correction in children with terminal stage of chronic kidney failure].
Content of vitamin D, evaluated by the level of 25(OH]D2 (calcidiol), was decreased in 68 patients with chronic kidney insufficiency, among which 16 patients required hemodialysis, 52 patients exhibited a terminal step of chronic kidney insufficiency and were treated with programme-assigned hemodialysis. Content of the vitamin was more distinctly decreased in the patients, kidney insufficiency of which developed simultaneously with congenital and hereditary kidney diseases. Phosphorus-calcium metabolism in the patients was corrected using both high doses of vitamin D2 (20,000 IU) and I alpha-hydroxycholecalciferol (oxidevite) combined with small doses of vitamin D2 (2,000 IU). The later procedure was more effective. After the treatment calcidiol was normalized within a month and maintained within a year at a level close to normal values. Blood calcium was normalized within 2 months, while normalization of parathormone and thyrocalcitonine occurred within a year. After treatment with vitamin D2 at a dose of 20,000 IU distinct hypercalcediolemia as observed in all the patients within 4 months. In 25% of the patients we noted hypercalcemia, which might lead to metastatic calcification.
Tsybysheva
A K
AK
Burkov
I V
IV
Blazhevich
N V
NV
Pereverzeva
O G
OG
Spirichev
V B
VB
D000293:Adolescent; D002118:Calcium / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004872:Ergocalciferols / Q000627:therapeutic use; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000378:metabolism / Q000628:therapy; D010758:Phosphorus / Q000378:metabolism; D006435:Renal Dialysis; D014808:Vitamin D Deficiency / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism
D004872:Ergocalciferols; D006887:Hydroxycholecalciferols; D010758:Phosphorus; D002118:Calcium; C008088:alfacalcidol
Obespechennost' vitaminom D deteĭ v terminal'noĭ stadii khronicheskoĭ pochechnoĭ nedostatochnosti i ee korrektsiia.