title: A novel non-H1, non-H2 histamine antagonist protects against cysteamine-induced duodenal ulcers in rats.
abstract: A newly synthesized para-diphenylmethane derivative, N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine-HCl (DPPE), binds with high affinity to the microsomal anti-estrogen binding site (AEBS). Recent data suggest that the DPPE/AEBS binding site is closely related to a novel low-affinity, non-H1, non-H2 histamine site which may be associated with a calcium channel. We previously have shown that DPPE markedly reduces stress-induced and ethanol-induced gastric ulcers and attenuates gastric acid secretion. We now show that DPPE also profoundly reduces cysteamine-induced duodenal ulcers in rats.
authors.affiliation: Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada.
authors.forename: G B
authors.initials: GB
authors.lastname: Glavin
authors.forename: L J
authors.initials: LJ
authors.lastname: Brandes
mesh_terms: D000818:Animals; D001665:Binding Sites; D003543:Cysteamine; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D006633:Histamine Antagonists / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D010647:Phenyl Ethers / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006633:Histamine Antagonists; D010647:Phenyl Ethers; D003543:Cysteamine; C043062:tesmilifene