title: [Age-related heart function in patients with healthy hearts].
abstract: Left ventricular function was investigated at rest and during submaximal exercise in 191 healthy subjects, including 46 women, by means of radionuclide ventriculography (RNV). As global parameters of heart function, ejection fraction (EF) and maximal rates of volume change during systole (VS) and diastole (VD) as well as endsystolic volume (ESV) were determined. These parameters were calculated for four age groups with mean ages of 32, 45, 55, and 64 years, respectively. At rest, heart rate (HR), EF, VS, and ESV were not significantly different in all age groups, whereas VD decreased with increasing age from 3.3 +/- 0.6 s-1 to 2.6 +/- 0.6 s-1. During exercise, HR, EF, VS, and VD increased in all groups, but less in the elderly. The smaller increase of EF and VD could be accounted for by HR alone. VS was both HR- and age-dependent. The age dependence of VD (at rest) and VS (under exercise) may reflect a reduction of myocardial compliance with increasing age. Differences of EF and VS with respect to sex were not observed, whereas VD was slightly lower in males.
authors.affiliation: Nuklearmedizinische Klinik und Poliklinik, Technische Universität München.
authors.forename: R
authors.initials: R
authors.lastname: Bauer
authors.forename: U
authors.initials: U
authors.lastname: Busch
authors.forename: E
authors.initials: E
authors.lastname: van de Flierdt
authors.forename: H
authors.initials: H
authors.lastname: Stettmeier
authors.forename: W
authors.initials: W
authors.lastname: Raab
authors.forename: H R
authors.initials: HR
authors.lastname: Langhammer
authors.forename: H W
authors.initials: HW
authors.lastname: Pabst
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002306:Cardiac Volume; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D012016:Reference Values; D013318:Stroke Volume; D016276:Ventricular Function
vernacular_title: Altersabhängigkeit der Herzfunktion bei Herzgesunden.