A platelet-activating factor antagonist inhibits interleukin 1-induced inflammation.
Treatment with a platelet-activating factor receptor antagonist, SRI 63-441, inhibited interleukin 1-induced increases in vascular permeability and leukocyte infiltration in the rabbit eye following the intravitreal injection of human interleukin 1-alpha. Treatment with the prostaglandin-synthetase inhibitor, flurbiprofen, or the corticosteroid, prednisolone, resulted in comparable attenuation of the increase in vascular permeability. In contrast to the effect of flurbiprofen, SRI 63-441 did not reduce interleukin 1-induced increases in prostaglandin E2 levels. Combined treatment with the platelet-activating factor antagonist and inhibitors of prostaglandin synthesis nearly prevented interleukin 1-induced increases in vascular permeability or cellular infiltration. These findings suggest a role for platelet-activating factor in interleukin 1-induced inflammation. Platelet-activating factor and prostaglandins may act synergistically as mediators of interleukin 1-induced vascular permeability.
Rubin
R M
RM
Department of Medicine, Oregon Health Sciences University, Portland 97201.
Rosenbaum
J T
JT
D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects* / Q000503:physiopathology; D002199:Capillary Permeability / Q000187:drug effects; D015232:Dinoprostone; D005123:Eye / Q000098:blood supply; D005260:Female; D005480:Flurbiprofen / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology*; D007375:Interleukin-1; D007958:Leukocyte Count; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D011239:Prednisolone / Q000494:pharmacology; D011458:Prostaglandins E / Q000032:analysis; D011506:Proteins / Q000032:analysis; D011806:Quinolinium Compounds / Q000494:pharmacology*; D011817:Rabbits; D011994:Recombinant Proteins
D007375:Interleukin-1; D010972:Platelet Activating Factor; D011458:Prostaglandins E; D011506:Proteins; D011806:Quinolinium Compounds; D011994:Recombinant Proteins; C050531:SRI 63-441; D005480:Flurbiprofen; D011239:Prednisolone; D015232:Dinoprostone