Isolation and structure of the cytostatic lignan glycoside phyllanthostatin A.
An unusual cytostatic (PS ED50 4 micrograms/ml) lignan ester has been isolated from the Central American tree Phyllanthus acuminatus and designated phyllanthostatin A [1]. Separation of an MeOH extract of the root by size exclusion chromatography, high speed counter-current distribution, and semipreparative hplc afforded glycoside 1 in 0.007% yield. In solution, phyllanthostatin A was slowly transformed into justicidin B [4]. The structure of lignan glycoside 1 was determined by hrfabms and 2D-nmr spectroscopy.
Pettit
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Cancer Research Institute, Arizona State University, Tempe 85287-1604.
Schaufelberger
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D002851:Chromatography, High Pressure Liquid; D006027:Glycosides / Q000302:isolation & purification*; D017705:Lignans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009281:Naphthalenes; D010936:Plant Extracts
D006027:Glycosides; D017705:Lignans; D009281:Naphthalenes; D010936:Plant Extracts; C058885:phyllanthostatin A