Tissue residues of diacetoxyscirpenol in pigs and calves after intravenous dosing.
Pigs (n = 19) were given 0, 0.1, 0.5, or 1 mg of diacetoxyscirpenol (DAS)/kg of body weight, and heifers (n = 7) were given 0 or 0.5 mg of DAS/kg. Animals were anesthetized and exsanguinated 8 hours after administration of DAS, and liver, kidney, skeletal muscle, mesenteric lymph node, and spleen were analyzed for DAS. Diacetoxyscirpenol was not detected in tissues from animals not given DAS. All tissues from pigs and calves given DAS contained at least traces (less than or equal to 10 ng/g of tissue) of DAS.
Coppock
R W
RW
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Swanson
S P
SP
Gelberg
H B
HB
Buck
W B
WB
D000818:Animals; D002417:Cattle / Q000378:metabolism*; D004350:Drug Residues / Q000032:analysis*; D005260:Female; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008198:Lymph Nodes / Q000378:metabolism; D008297:Male; D008643:Mesentery; D009132:Muscles / Q000378:metabolism; D011897:Random Allocation; D012717:Sesquiterpenes / Q000032:analysis*; D013154:Spleen / Q000378:metabolism; D013552:Swine / Q000378:metabolism*; D014255:Trichothecenes / Q000032:analysis* / Q000493:pharmacokinetics
D012717:Sesquiterpenes; D014255:Trichothecenes; C001809:diacetoxyscirpenol