Cerebral involvement in systemic lupus erythematosus.
Four patients with central nervous system lupus erythematosus (SLE), were studied with nuclear magnetic resonance imaging (NMRI) and positron emission tomography (PET) to assess cerebral blood flow and glucose metabolism. The NMRI showed brain atrophy and demyelinating defects. The PET scan showed cerebral blood flow and metabolic abnormalities that improved in one patient after neuropsychiatric recovery. These preliminary findings demonstrate cerebral derangements in patients with SLE cerebritis.
Volkow
N D
ND
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston 77030.
Warner
N
N
McIntyre
R
R
Valentine
A
A
Kulkarni
M
M
Mullani
N
N
Gould
L
L
D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D014055:Tomography, Emission-Computed