title: Relationships of low density lipoprotein cholesterol with age and other factors: a cross-sectional analysis of the CARDIA study.
abstract: Presumed evolution of low density lipoprotein cholesterol (LDL-C) was studied in a baseline cross-sectional survey of 4955 18-30 year old men and women of various sociodemographic backgrounds. Specifically studied were the influences on LDL-C and the change of LDL-C with age of race, gender, education, diet, physical activity, fatness and fitness. Men increased about 20 mg/dl per 10 years of age, while women increased about 3 mg/dl. Increasing education was found to be associated with higher LDL-C in blacks, but with lower LDL-C in whites. Higher Keys diet score and body mass index were positively associated with LDL-C, while higher total caloric intake, vigorous physical activity, duration on a treadmill exercise test and usual intake of alcohol were negatively associated with LDL-C. The finding of a different relationship of LDL-C to increasing education in whites than in blacks suggests a cultural or behavioral influence in rate of increase in LDL-C.
authors.affiliation: Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis.
authors.forename: D R
authors.initials: DR
authors.lastname: Jacobs
authors.forename: G L
authors.initials: GL
authors.lastname: Burke
authors.forename: K
authors.initials: K
authors.lastname: Liu
authors.forename: G
authors.initials: G
authors.lastname: Cutter
authors.forename: G
authors.initials: G
authors.lastname: Hughes
authors.forename: S
authors.initials: S
authors.lastname: Hulley
authors.forename: S
authors.initials: S
authors.lastname: Sidney
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D000375:Aging / Q000097:blood*; D001835:Body Weight; D008078:Cholesterol, LDL / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004522:Educational Status; D002149:Energy Intake; D005260:Female; D006801:Humans; D008297:Male; D010809:Physical Fitness; D012307:Risk Factors
chemical_list: D008078:Cholesterol, LDL