A twin study of febrile convulsions in the general population.
Seven monozygotic (MZ) and six dizygotic (DZ) twin pairs with febrile convulsions (FC) in the general population were studied. The pairwise concordance rate for FC in MZ 85.7% (6/7) was higher than that in DZ 16.7% (1/6). In a discordant MZ pair, the unaffected co-twin was attacked by epileptic seizures later. Between the concordant DZ twins, the clinical symptoms and EEGs differed in quality. According to the ratio of concordance rate in MZ to that in DZ 5.1, a multifactorial mode of inheritance for FC was suspected.
Sunami
K
K
Department of Human Genetics, Tokyo Metropolitan Institute for Neurosciences.
Hayashi
N
N
Endo
S
S
D002648:Child; D004200:Diseases in Twins; D006801:Humans; D003294:Seizures, Febrile / Q000235:genetics*; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic