Novel formazans as potent anti-inflammatory and analgesic agents.
Various new substituted formazans were synthesized and characterized by elemental analyses, IR and mass spectral data. The compounds were evaluated for their ability to protect against inflammation by carrageenin-induced paw edema in albino rats of either sex. The active derivatives of the present series were also tested for their analgesic activity against aconitine-induced writhing in albino mice and ulcerogenic activity in albino rats. The toxicity of the compounds was assessed by determination of their approximate LD50 on albino mice. An attempt has also been made to establish a structure-activity relationship.
Kalsi
R
R
Jawahar Lal Nehru Laboratory of Molecular Biology, Department of Pharmacology and Therapeutics, King George's Medical College, Lucknow, India.
Pande
K
K
Bhalla
T N
TN
Parmar
S S
SS
Barthwal
J P
JP
D000700:Analgesics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001391:Azo Compounds / Q000494:pharmacology*; D004487:Edema / Q000517:prevention & control; D005260:Female; D005562:Formazans / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy; D051381:Rats; D013329:Structure-Activity Relationship; D014456:Ulcer / Q000139:chemically induced
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001391:Azo Compounds; D005562:Formazans