In vitro induction of differentiation in HL-60 leukemic cell line by clerodendron fragrans.
The promyelocytic cell line HL-60 could be induced to differentiate into morphologically and functionally mature monocytoid cells (up to 20%) following exposure to the Chinese herb Clerodendron Fragrans (1 mg/ml). This effect was time dependent and appeared to work synergistically with interferon-r in this promotion of differentiation. Our study suggests that Clerodendron Fragrans has potential therapeutic value for the treatment of certain acute myelocytic leukemia putatively caused by a block in the myeloid differentiation process.
Chen
P M
PM
Department of Medicine, Veterans General Hospital, Taipei, Taiwan.
Yung
L L
LL
Hsiao
K I
KI
Chen
C M
CM
Yeh
H M
HM
Chuang
M H
MH
Tzeng
C H
CH
D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D004365:Drugs, Chinese Herbal