title: Blended effects of herbal components of tokishakuyakusan on rat corpus luteum function in vivo.
abstract: The effect of herbal components of Tokishakuyakusan on progestin levels in serum and ovarian tissue from rats treated with PMS and hCG was examined in vivo. Hoelen + peony root + Japanese angelica root increased progesterone/20 alpha-OHP ratio in serum, and hoelen or peony root also increased the ratio in ovarian tissue, while atractylodes lanceae rhizome or hoelen + atractylodes lanceae rhizome decreased the ratio in serum and ovarian tissue. These data suggested that hoelen or peony root has a luteotropic effect but that atractylodes lanceae rhizome develops luteolysis. Furthermore, the data indicated a blended effect of herbal components of Tokishakuyakusan on the corpus luteum.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tsukuba, Ibaraki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Usuki
mesh_terms: D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects* / Q000502:physiology; D004339:Drug Compounding; D004365:Drugs, Chinese Herbal; D005260:Female; D006027:Glycosides / Q000494:pharmacology*; D010946:Plants, Medicinal; D011374:Progesterone / Q000096:biosynthesis; D051381:Rats
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; C413220:toki-shakuyaku-san; D011374:Progesterone