[Cytogenetic studies of lung cancer].
Chromosome analysis was performed on tumor cells from 15 patients with lung cancer. The G-banding techniques were used for analysis of karyotypes. The results showed that numerical and structural abnormalities were found in each case. Chromosomal numbers varied in a range of 36-240. Aneuploids were present in 91.62% of all cells. The most common numerical alterations were subtriploidies and triploidies. Chromosomes 1, 11, 4, 5, and 3 were most frequently involved in 21 marker chromosomes. It was found that marker chromosomes M1, M3, M4 and M5 were related to chromosome 1 with the breakpoints assigned to 1p11, 1q11, 1p35 and an area of centromere. This result may suggest that breakpoint of chromosome 1 be related to the expression of oncogene of the lung cancer.
Fang
Y
Y
Cancer Institute, Zhongshan University of Medical Sciences, Guangzhou.
D000230:Adenocarcinoma / Q000235:genetics; D000368:Aged; D000782:Aneuploidy; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011123:Polyploidy
D005819:Genetic Markers