The electrogenic Na-K pump does not contribute to endothelium-dependent hyperpolarization in the rabbit ear artery.
The application to smooth muscle cells of the rabbit ear artery, of either K ions after incubation with K-free solution, or of ACh produced a transient hyperpolarization of the membrane. Ouabain inhibited the former hyperpolarization but not the latter, indicating that the electrogenic Na-K pump possibly does not contribute to the endothelium-dependent hyperpolarization.
Suzuki
H
H
Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004423:Ear / Q000098:blood supply* / Q000187:drug effects; D004553:Electric Conductivity / Q000187:drug effects*; D004727:Endothelium / Q000187:drug effects / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology*; D011817:Rabbits; D012964:Sodium / Q000494:pharmacology*
D010042:Ouabain; D012964:Sodium; D000109:Acetylcholine; D011188:Potassium