[Synthesis of carbon-14 labeled 1-acetoxyethyl 2-(2-fluoro-4-biphenyl)propionate (14C-FP 83)].
1-Acetoxyethyl 2-(2-fluoro-4-biphenylyl) [14C-methyl]propionate (14C-Me-FP 83), a novel nonsteroidal antiinflammatory agent for injection, was synthesized in order to investigate the metabolic fate. 14C-Me-FP 83 was obtained by the condensation of 2-(2-fluoro-4-biphenylyl) [14C-methyl]propionic acid with 1-chloroethyl acetate. The chemical yield of 1 was 62% after purification. The specific activity was 258 kBq/mg (6.99 microCi/mg) and its radiochemical purity was 99% in thin layer chromatographic method.
Uchida
K
K
Central Research Laboratories, Kaken Pharmaceutical Co. Ltd., Kyoto.
Konishi
Y
Y
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001713:Biphenyl Compounds / Q000138:chemical synthesis; D002250:Carbon Radioisotopes; D007553:Isotope Labeling / Q000379:methods*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001713:Biphenyl Compounds; D002250:Carbon Radioisotopes; C059375:FP 83