Regional haemodynamic responses to intracerebroventricular administration of rat calcitonin gene-related peptide in conscious, Long-Evans and Brattleboro rats.
Rat calcitonin gene-related peptide (CGRP) was administered intracerebroventricularly (0.25 nmol in 5 microliter) to conscious, Long-Evans and Brattleboro rats, chronically instrumented with pulsed Doppler probes around the left renal and superior mesenteric arteries and the distal abdominal aorta. Tachycardias occurred in both strains, but only in Long-Evans rats was there a (modest) pressor effect of CGRP. However, both strains of rat showed renal vasodilatation and mesenteric vasoconstriction. These results indicate that the central pressor effect of CGRP in Long-Evans rats may not be due to generalized sympathetic activation, and make it unlikely that circulating vasopressin contributes to the mesenteric vasoconstriction.
Gardiner
S M
SM
Department of Physiology and Pharmacology, Medical School, Queen's Medical School, Nottingham, U.K.
Compton
A M
AM
Bennett
T
T
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D015740:Calcitonin Gene-Related Peptide; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects / Q000294:innervation; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics; D007276:Injections, Intraventricular; D009479:Neuropeptides / Q000494:pharmacology*; D051381:Rats; D011910:Rats, Brattleboro; D013045:Species Specificity; D014655:Vascular Resistance / Q000187:drug effects
D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide