Infantile subcortical leukohypodensity demonstrated by computed tomography.
We reviewed the computed tomography scans of 126 term infants, ages 1-6 months; leukohypodensity was found just under the cerebral cortex (subcortical leukohypodensity [SLD]) in 3 infants (2.4%) at 1-3 months of age. On subsequent computed tomography at over 4 months of age, SLD had disappeared and anterior horn predominant dilatation of the lateral ventricles had appeared. Only 1 patient with a distinct SLD had a poor neurodevelopmental outcome: spastic diplegia. SLD in our patients is believed to be closely related to subcortical leukomalacia because of the similar location and age distribution. Transient SLD may be a mild form of cystic SLD which would require careful computed tomography follow-up examination in early infancy.
Houdou
S
S
Division of Child Neurology, Tottori University School of Medicine, Yonago, Japan.
Takashima
S
S
Takeshita
K
K
Ohta
S
S
D001724:Birth Weight; D002540:Cerebral Cortex / Q000000981:diagnostic imaging; D004678:Encephalomalacia / Q000000981:diagnostic imaging*; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000000981:diagnostic imaging; D007969:Leukomalacia, Periventricular / Q000000981:diagnostic imaging*; D008297:Male; D012307:Risk Factors; D014057:Tomography, X-Ray Computed