Renal nerves and sodium conservation in conscious rats of different strains kept on various diets.
Earlier contradictory results as to whether renal nerves are necessary for adaptation to a low dietary sodium intake in the rat were ascribed to strain differences or to sympathetic stimulation caused by carbohydrates when changing from a low-sucrose normal-sodium diet to a high-sucrose sodium-deficient diet. In the present work, daily sodium excretion was studied for 4 days before and after bilateral renal denervation or sham operation in three strains of rats (CFY, Wistar, and Long Evans). After ingesting a normal sodium diet containing no sucrose, CFY and Wistar rats were fed a sodium-deficient diet containing 67% sucrose. Long Evans rats were sodium-depleted by feeding them boiled rice. Daily and cumulative sodium excretion and sodium balance were similar in all three groups during 4-day sodium-depletion periods before and after bilateral renal denervation or sham operation. The results suggest that in sodium-depleted rats denervation natriuresis can be ascribed neither to strain differences nor to the high sucrose content of the low-sodium diet.
Takács
L
L
Division of Clinical Immunology, Nephrology and Endocrinology, Joint Research Organization of the Hungarian Academy of Sciences, Budapest.
Szénási
G
G
Bencsáth
P
P
D000818:Animals; D001835:Body Weight; D004032:Diet; D004039:Diet, Sodium-Restricted; D007668:Kidney / Q000294:innervation* / Q000502:physiology; D008297:Male; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012964:Sodium / Q000378:metabolism* / Q000652:urine; D013045:Species Specificity; D013562:Sympathectomy
D012964:Sodium; D011188:Potassium