title: Gastric relaxation and vasoactive intestinal peptide output in response to reflex vagal stimulation in the dog.
abstract: 1. Gastric relaxation, vasodilatation and vasoactive intestinal peptide (VIP) output from the stomach in response to stimulation of the central end of the cut vagus nerve were studied in anaesthetized dogs. 2. Central vagal stimulation (10 Hz, 40 V, 0.5 ms) normally produced a non-adrenergic, non-cholinergic (NANC) gastric relaxation via a vago-vagal reflex. It also caused an increase followed by a decrease in gastric blood flow. 3. The increase in blood flow was attributable to a NANC gastric vasodilatation via a vago-vagal reflex and the subsequent reduction in blood flow was decreased by splanchinicotomy. All these gastric and vascular responses were abolished by hexamethonium. 4. The gastric relaxation and vasodilatation induced by the vago-vagal reflex had similar stimulation frequency-response and pulse duration-response relations. 5. Central vagal stimulation caused an increase in gastric venous VIP output which was abolished by vagotomy or hexamethonium but unaffected by splanchnicotomy. 6. VIP injected into the gastric artery mimicked the gastric relaxant and vasodilator responses to the vago-vagal reflex. 7. We conclude that the intramural NANC inhibitory nerves activated by the vago-vagal reflex release VIP which causes both gastric relaxation and vasodilatation.
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, Hokkaido University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.forename: A
authors.initials: A
authors.lastname: Ohga
authors.forename: T
authors.initials: T
authors.lastname: Ohta
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009126:Muscle Relaxation; D010646:Phentolamine / Q000494:pharmacology; D013270:Stomach / Q000098:blood supply / Q000294:innervation*; D014630:Vagus Nerve / Q000502:physiology*; D014655:Vascular Resistance; D014660:Vasoactive Intestinal Peptide / Q000097:blood* / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects
chemical_list: D014660:Vasoactive Intestinal Peptide; D010646:Phentolamine