title: A comparative study of the interactions of alcohol with amitriptyline, fluoxetine and placebo in normal subjects.
abstract: 1. Twelve normal volunteer subjects were given amitriptyline, fluoxetine and placebo in clinically relevant doses, each for a period of 7 days. A minimum of 28 days intervened between each drug treatment. 2. A battery of physiological, psychomotor and subjective tests was administered before drugs and on days 4 and 8. 3. On day 8 a measured dose of alcohol was given and the tests repeated 1 hour and 3 hours later. 4. Before alcohol, little effect was shown on physiological or psychomotor activity. Subjective ratings indicated that amitriptyline was less-well tolerated than fluoxetine. 5. Significant differences were found for many measures after alcohol but there were few differences with respect to the drugs.
authors.affiliation: Department of Psychiatry, Institute of Psychiatry, London, England.
authors.forename: D
authors.initials: D
authors.lastname: Allen
authors.forename: M
authors.initials: M
authors.lastname: Lader
authors.forename: H V
authors.initials: HV
authors.lastname: Curran
mesh_terms: D000428:Alcohol Drinking / Q000523:psychology*; D000639:Amitriptyline / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004569:Electroencephalography; D000431:Ethanol / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008606:Mental Processes / Q000187:drug effects*; D011437:Propylamines / Q000494:pharmacology*
chemical_list: D011437:Propylamines; D005473:Fluoxetine; D000639:Amitriptyline; D000431:Ethanol