[Immunological elimination of cytogenetically aberrant cells induced by infectious factors].
Injection of measles virus and streptolysin-O into the cultures of human fibroblasts (HF) significantly increased the number of cells with cytogenetic aberrations. Injection of non-immune autologous T-lymphocytes resulted in the decrease in the number of aneuploid HF leading to the intact condition. Immune homologous T-lymphocytes, in contrast to non-immune autologous ones, were shown to remove cells with structural chromosome damage, without affecting the number of polyploid and aneuploid cells. Two equally possible suggestions can be made concerning non-immune autologous T-lymphocytes: 1) T-lymphocytes remove HF having virus antigens on their surface or 2) T-lymphocytes define and eliminate fibroblasts with the cell surface changed, as a result of virus-induced damage.
Il'inskikh
N N
NN
D000782:Aneuploidy; D000917:Antibody Formation; D001426:Bacterial Proteins; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006801:Humans; D007111:Immunity, Cellular; D007114:Immunization; D007231:Infant, Newborn; D008457:Measles / Q000235:genetics / Q000276:immunology*; D011123:Polyploidy; D013301:Streptolysins / Q000633:toxicity*; D013601:T-Lymphocytes / Q000276:immunology
D001426:Bacterial Proteins; D013301:Streptolysins; C025964:streptolysin O
Immunologicheskaia éliminatsiia tsitogeneticheski aberrantnykh kletok, indutsirovannykh infektsionnymi faktorami.