Psychopharmacological profile of 1-(m-(trifluoromethyl) phenyl) piperazine (TFMPP).
The effect of TFMPP, an agonist of the 5-HT1b receptors, was studied in mice on several psychopharmacological parameters. In contrast to imipramine-like drugs, TFMPP neither antagonized reserpine-induced hypothermia nor increased yohimbine-induced toxicity. Similarly to imipramine-like drugs, TFMPP antagonized oxotremorine-induced hypothermia and was active in the behavioural despair test. In addition, TFMPP normalized a social behavioural deficit induced by isolation. The effects of TFMPP on oxotremorine-induced hypothermia in the behavioural despair test and in the isolation-induced social behavioural deficit are all antagonized by d-1 propranolol. It is concluded that TFMPP seems to possess psychotropic activity resembling only in part that of imipramine-like drugs and that these actions may be mediated through 5-HT1b receptors.
Frances
H
H
INSERM U-302, Faculté de Médecine Pitié Salpêtrière, Paris.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects; D004357:Drug Synergism; D007036:Hypothermia, Induced; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010095:Oxotremorine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D011600:Psychopharmacology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012110:Reserpine / Q000494:pharmacology; D012919:Social Behavior / Q000187:drug effects; D012934:Social Isolation / Q000187:drug effects; D015016:Yohimbine / Q000494:pharmacology / Q000633:toxicity
D010879:Piperazines; D011985:Receptors, Serotonin; C018406:1-(3-trifluoromethylphenyl)piperazine; D015016:Yohimbine; D010095:Oxotremorine; D012110:Reserpine; D011433:Propranolol