title: Indicators of lead, zinc and cadmium exposure in cattle: II. Controlled feeding and recovery.
abstract: Two pre-exposed and 2 normal heifers were fed lead (Pb), zinc (Zn), and cadmium (Cd) polluted hay (500 g/100 kg body weight) over a 17-week period. They were then examined over a 10-month period (42 or 38 weeks) to study the decay of the indicators of exposure. The elimination pattern of blood Pb and Zn protoporphyrin concentrations displayed a very slow decay. A bi-exponential equation, with the half-times of the fast component set at approximately 1 week, and the half-times of the slow component set from 3 mo to 2 years, was fitted to blood Pb levels. In man, the half-life of the slow component is still longer (2 to 15 years). This slow elimination rate represents release of Pb from skeleton, which in bovines, may accumulate up to 100 ppm Pb/dry or more. Lead concentrations in the hair were not proportionate to the areas under the curves of blood Pb levels; there was the same lack of correlation concerning skeleton and viscerae Pb levels. The withdrawal of contaminated hay from the diet resulted in a significant increase in blood copper. This is in accordance with the depressive effect of Pb and Zn on the bioavailability of this metal.
authors.affiliation: Pharmacy and Toxicology, National Veterinary School Alfort.
authors.forename: S
authors.initials: S
authors.lastname: Mehennaoui
authors.forename: E
authors.initials: E
authors.lastname: Charles
authors.forename: B
authors.initials: B
authors.lastname: Joseph-Enriquez
authors.forename: M
authors.initials: M
authors.lastname: Clauw
authors.forename: G E
authors.initials: GE
authors.lastname: Milhaud
mesh_terms: D000821:Animal Feed / Q000633:toxicity*; D000818:Animals; D002104:Cadmium / Q000378:metabolism / Q000633:toxicity*; D002417:Cattle; D005260:Female; D005506:Food Contamination; D006197:Hair / Q000032:analysis; D007854:Lead / Q000378:metabolism / Q000633:toxicity*; D011524:Protoporphyrins / Q000097:blood / Q000378:metabolism; D014018:Tissue Distribution; D015032:Zinc / Q000378:metabolism / Q000633:toxicity*
chemical_list: D011524:Protoporphyrins; D002104:Cadmium; C017803:zinc protoporphyrin; D007854:Lead; D015032:Zinc