Do serotoninergic drugs decrease energy intake by reducing fat or carbohydrate intake? Effect of d-fenfluramine with supplemented weight-increasing diets.
The capacity of serotoninergic drugs to selectively suppress carbohydrate (CHO) intake was investigated using a procedure sensitive to drug action. The drug d-fenfluramine was administered chronically to rats whose weight had been increased by exposure to either a fat or CHO-supplemented hyperphagia-inducing diet. The drug exerted a more potent anorexic effect and weight-reducing action in rats given the dietary supplements than in control chow-fed rats. Tolerance to the drug was not apparent even after 40 days of treatment. However, there was no evidence for a selective inhibition of CHO intake, nor was the drug more potent with the CHO-supplemented diet. d-Fenfluramine was equally effective against the hyperphagia and weight gain induced by either fat or CHO supplements.
Blundell
J E
JE
Psychology Department, University of Leeds, U.K.
Hill
A J
AJ
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D004327:Drinking Behavior / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology*; D051381:Rats
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005277:Fenfluramine