Maternal arterial desaturation with 15-methyl prostaglandin F2 alpha for uterine atony.
Over a six-month period, five women with severe uterine atony and postpartum hemorrhage developed marked maternal arterial oxygen desaturation within five to ten minutes of the administration of 15-methyl prostaglandin F2 alpha. The average fall from baseline was 10.4 +/- 5.4%, to a mean arterial oxygen saturation of 88.8 +/- 5.45%. The desaturation was accompanied by acute increases, averaging 20.7 +/- 5.9%, in the intrapulmonary shunt.
Hankins
G D
GD
Department of Obstetrics and Gynecology, Wilford Hall United States Air Force Medical Center, Lackland Air Force Base, Texas.
Berryman
G K
GK
Scott
R T
RT
Hood
D
D
D001784:Blood Gas Analysis; D002260:Carboprost / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D006473:Postpartum Hemorrhage / Q000097:blood*; D011247:Pregnancy; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects*; D013997:Time Factors; D014593:Uterine Inertia / Q000097:blood* / Q000150:complications / Q000188:drug therapy
D011461:Prostaglandins F, Synthetic; D002260:Carboprost; D010100:Oxygen