Mass spectrometry of electrophore-labeled nucleosides. Pentafluorobenzyl and cinnamoyl derivatives.
Three structurally similar deoxynucleosides (thymidine, O4-ethylthymidine, and 2'-deoxyuridine) were studied by mass spectrometry as pentafluorobenzyl, cinnamyl, or mixed derivatives. The purpose of the work was to define the usefulness of such derivatives for structural elucidation of deoxynucleosides. The compounds were ionized in three ways: electron capture negative ion, positive ion chemical ionization, and electron impact. For each of the derivatives examined, the combined spectra were well suited for structural elucidation purposes.
Trainor
T M
TM
Department of Chemistry, Northeastern University, Boston, MA 02115.
Giese
R W
RW
Vouros
P
P
D001593:Benzyl Compounds / Q000302:isolation & purification*; D002849:Chromatography, Gas; D002934:Cinnamates / Q000302:isolation & purification*; D003853:Deoxyribonucleosides / Q000302:isolation & purification*; D003857:Deoxyuridine / Q000031:analogs & derivatives / Q000302:isolation & purification; D004563:Electrochemistry; D005461:Fluorine / Q000302:isolation & purification; D008401:Gas Chromatography-Mass Spectrometry; D013058:Mass Spectrometry; D013936:Thymidine / Q000031:analogs & derivatives / Q000302:isolation & purification
D001593:Benzyl Compounds; D002934:Cinnamates; D003853:Deoxyribonucleosides; D005461:Fluorine; D013936:Thymidine; D003857:Deoxyuridine