title: Influence of ion-pair-formation on the pharmacokinetic properties of drugs. Part 4: Influence of hexylsalicylic acid on the pharmacokinetics of bretylium.
abstract: Based on in vitro results it was found that the pharmacokinetic parameters of the hydrophilic drug bretylium (2) can be influenced by an ion-pair-formation with the lipophilic hexylsalicyclic acid (1). After simultaneous i.v. application of 1 and 2 on rabbits a significant increase of the AUC of 2 was observed. Under these conditions a marked increase of the AUC and the MRT of 1 was also obtained, since the blood levels of 2 are high enough for such an influence. A combined rectal application of 1 and 2 causes an increase of the AUC of 2.
authors.affiliation: Sektion Pharmazie, Martin-Luther-Universität Halle.
authors.forename: R
authors.initials: R
authors.lastname: Neubert
authors.forename: A
authors.initials: A
authors.lastname: Ritter
authors.forename: E
authors.initials: E
authors.lastname: Stolte
authors.forename: G
authors.initials: G
authors.lastname: Albrecht
authors.forename: H J
authors.initials: HJ
authors.lastname: Loh
authors.forename: M
authors.initials: M
authors.lastname: Jirka
authors.forename: W
authors.initials: W
authors.lastname: Fürst
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001949:Bretylium Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004347:Drug Interactions; D007275:Injections, Intravenous; D011817:Rabbits; D012459:Salicylates / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D001949:Bretylium Compounds; D012459:Salicylates; C059285:3-hexylsalicylic acid