title: Effects of flunarizine on postischemic blood flow, energy metabolism and neuronal damage in the rat brain.
abstract: The effects of flunarizine on local cerebral blood flow, cortical energy metabolism and neuronal necrosis were evaluated in a rat model of forebrain ischemia. The application of flunarizine (2 X 40 mg/kg p.o.) at 24 and 4 h before ischemia accelerated the restoration of cortical high-energy phosphates during early post-ischemic recirculation and also increased the flow in cortical but not in hippocampal areas. Neuronal necrosis was reduced in the hippocampal CA 1 sector but unchanged in the cortex. It is concluded that flunarizine reduces ischemic damage mainly via a direct effect on brain tissue.
authors.affiliation: Institut für Pharmakologie und Toxikologie, Philipps-Universität, Marburg, F.R.G.
authors.forename: T
authors.initials: T
authors.lastname: Beck
authors.forename: J
authors.initials: J
authors.lastname: Nuglisch
authors.forename: D
authors.initials: D
authors.lastname: Sauer
authors.forename: G W
authors.initials: GW
authors.lastname: Bielenberg
authors.forename: H D
authors.initials: HD
authors.lastname: Mennel
authors.forename: C
authors.initials: C
authors.lastname: Rossberg
authors.forename: J
authors.initials: J
authors.lastname: Krieglstein
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D005444:Flunarizine / Q000494:pharmacology*; D006624:Hippocampus / Q000098:blood supply / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D010710:Phosphates / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010710:Phosphates; D005444:Flunarizine