Tendon cell outgrowth rates and morphology associated with kevlar-49.
A rat tendon cell model was used to evaluate the in vitro biocompatibility of kevlar-49. The cell response to kevlar was compared to carbon AS-4 and nylon sutures. Three trials were run and cell growth rates were statistically similar for all the materials tested. A separate experiment was conducted in which the same fiber materials were placed in the same Petri dish. Again, the rates were similar for each material. Finally, the cells were observed with a scanning electron microscope, and the three classic cell morphologies associated with this tendon cell model were observed. Also, cellular attachment to the fiber and cellular encapsulation of the fiber were identical for the three materials tested. Kevlar-49 proved to be comparable to carbon AS4 and nylon sutures in terms of cellular response and cell outgrowth rates.
Zimmerman
M
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Orthopaedic Engineering and Research Center, Helen Hayes Hospital, West Haverstraw, New York 10993.
Gordon
K E
KE
D000818:Animals; D001672:Biocompatible Materials; D002448:Cell Adhesion; D002455:Cell Division; D005347:Fibroblasts; D008297:Male; D008422:Materials Testing; D008854:Microscopy, Electron; D009757:Nylons; D011108:Polymers; D051381:Rats; D011919:Rats, Inbred Strains; D013537:Sutures; D013710:Tendons / Q000166:cytology*
D001672:Biocompatible Materials; D009757:Nylons; D011108:Polymers; C058852:Kevlar 49