title: Control of IGF-II mRNA levels by glucocorticoids in the neonatal rat.
abstract: Insulin-like growth factor-II (IGF-II) is thought to be a major growth factor during fetal and neonatal development. Levels of IGF-II mRNA fall dramatically in the liver - the major site of endocrine production - between 18 and 20 days post-natally. No information concerning the control of gene expression post-natally has hitherto been available. Using Northern blotting and in-situ hybridization, we show here that cortisone acetate rapidly extinguishes IGF-II mRNA expression in the neonatal rat liver. The effect at putative autocrine/paracrine locations such as skeletal muscle and choroid plexus is much less marked or absent. The repression by cortisone acetate is discussed in the light of the available IGF-II gene sequence.
authors.affiliation: Department of Anatomy, University of Leicester.
authors.forename: F
authors.initials: F
authors.lastname: Beck
authors.forename: N J
authors.initials: NJ
authors.lastname: Samani
authors.forename: P
authors.initials: P
authors.lastname: Senior
authors.forename: S
authors.initials: S
authors.lastname: Byrne
authors.forename: K
authors.initials: K
authors.lastname: Morgan
authors.forename: R
authors.initials: R
authors.lastname: Gebhard
authors.forename: W J
authors.initials: WJ
authors.lastname: Brammar
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D015152:Blotting, Northern; D002831:Choroid Plexus / Q000378:metabolism; D003348:Cortisone / Q000031:analogs & derivatives* / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects*; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000502:physiology; D051381:Rats; D013002:Somatomedins / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D013002:Somatomedins; D007335:Insulin-Like Growth Factor II; D003348:Cortisone