title: The effects of E series prostaglandins on blastogenic responses in vitro and graft vs. host responses in vivo.
abstract: In this study the ability of prostaglandin E1 (PGE1), Misoprostol (a stable analog of PGE1), and 16,16-dimethyl PGE2 (a stable analog of PGE2) to suppress immune responses in vitro and in vivo was determined. All of the compounds caused a titratable (10(-6) to 10(-9) M) suppression of Con A blastogenesis and the mixed lymphocyte response whereas there was only slight inhibition of the LPS response. When either 16,16-dimethyl PGE2 (30 ug/mouse) or Misoprostol (60 ug/mouse) was administered daily in vivo, there was a significant suppression of splenomegaly in F1 mice (C57Bl/6 x CBA) which had been injected with parental (C57Bl/6) spleen cells. We conclude that prostaglandins of the E series can function as immunosuppressive reagents both in vitro and in vivo. In the future they may serve to augment existing forms of immunosuppressive therapy.
authors.affiliation: Department of Pathology, Loyola University School of Medicine, Maywood, Illinois 60153.
authors.forename: G P
authors.initials: GP
authors.lastname: Duffie
authors.forename: R R
authors.initials: RR
authors.lastname: Romanelli
authors.forename: N K
authors.initials: NK
authors.lastname: Ellis
authors.forename: M R
authors.initials: MR
authors.lastname: Young
authors.forename: H T
authors.initials: HT
authors.lastname: Wepsic
mesh_terms: D000818:Animals; D000917:Antibody Formation; D006087:Graft vs Host Reaction / Q000187:drug effects*; D007165:Immunosuppression Therapy; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011458:Prostaglandins E / Q000494:pharmacology*; D011462:Prostaglandins G / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D011458:Prostaglandins E; D011462:Prostaglandins G