title: Isolation and structure of the cytostatic lignan glycoside phyllanthostatin A.
abstract: An unusual cytostatic (PS ED50 4 micrograms/ml) lignan ester has been isolated from the Central American tree Phyllanthus acuminatus and designated phyllanthostatin A [1]. Separation of an MeOH extract of the root by size exclusion chromatography, high speed counter-current distribution, and semipreparative hplc afforded glycoside 1 in 0.007% yield. In solution, phyllanthostatin A was slowly transformed into justicidin B [4]. The structure of lignan glycoside 1 was determined by hrfabms and 2D-nmr spectroscopy.
authors.affiliation: Cancer Research Institute, Arizona State University, Tempe 85287-1604.
authors.forename: G R
authors.initials: GR
authors.lastname: Pettit
authors.forename: D E
authors.initials: DE
authors.lastname: Schaufelberger
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006027:Glycosides / Q000302:isolation & purification*; D017705:Lignans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009281:Naphthalenes; D010936:Plant Extracts
chemical_list: D006027:Glycosides; D017705:Lignans; D009281:Naphthalenes; D010936:Plant Extracts; C058885:phyllanthostatin A