Suppression of human cytotoxic T lymphocyte responses by adherent peripheral blood leukocytes.
Cytotoxic T lymphocyte (CTL) responses to HLA alloantigens are unexpectedly weak compared to the CTL response to influenza virus. Allogeneic CTL activity was increased dramatically by removal of a Leu M3+ cell with adherence properties. The Leu M3+-enriched population was capable of suppressing the allogeneic-CTL response. Precultured cells suppressed both allogeneic and influenza-specific CTL responses. Inactivation of suppression was achieved by addition of influenza virus to the cultures in which suppressor activity was generated. A high proportion of asymptomatic HIV-seropositive and AIDS patients, as well as one high-risk group appear to have lost suppressor-cell activity. These findings are discussed with respect to the possible role of this suppressor system in transplantation immunology and the T cell-immune abnormalities observed in development of AIDS.
Bernstein
D C
DC
Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892.
Shearer
G M
GM
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D002448:Cell Adhesion; D002478:Cells, Cultured; D006678:HIV / Q000276:immunology; D006679:HIV Seropositivity; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007519:Isoantigens / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D006680:HLA Antigens; D007519:Isoantigens