Effects of T-2 mycotoxin on tumor susceptibility in mice.
The effect of Fusarium-produced T-2 toxin on tumor growth was evaluated in ICR, CFW, and C57B6/6 mice inoculated with murine sarcoma, Ehrlich ascites carcinoma, or B16F1 melanoma tumor cell lines. Mice were given T-2 toxin intragastrically either at the rate of 2 mg of toxin/kg of body weight daily for 5 days or a single dosage of 4 mg of toxin/kg and were inoculated SC with tumor cells 1 or 2 days after administration of toxin. Tumor growth was assessed 15 to 41 days after tumor challenge by determining the frequency of tumor development and tumor weights. Significant increases in the frequency of development of murine sarcoma (P less than 0.005), Ehrlich ascites carcinoma (P less than 0.01), and B16F1 melanoma tumors (P less than 0.05) were detected in toxin-treated mice, compared with control mice. Murine sarcoma and B16F1 melanoma tumor weights also were significantly (P less than 0.01) higher in toxin-treated mice. The effect of T-2 toxin on tumor growth was more marked after 5 daily treatments than after a single dose.
Corrier
D E
DE
USDA, Veterinary Toxicology and Entomology Research Laboratory, College Station, TX 77841.
Norman
J O
JO
D000818:Animals; D002277:Carcinoma / Q000473:pathology; D002460:Cell Line; D004198:Disease Susceptibility; D005260:Female; D007166:Immunosuppressive Agents; D008297:Male; D008545:Melanoma / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology*; D012509:Sarcoma / Q000473:pathology; D012717:Sesquiterpenes / Q000633:toxicity*; D013605:T-2 Toxin / Q000633:toxicity*
D007166:Immunosuppressive Agents; D012717:Sesquiterpenes; D013605:T-2 Toxin