title: HIPDM-SPECT in patients with medically intractable complex partial seizures. Ictal study.
abstract: Both interictal and ictal N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3,propanediamine -single photon emission computed tomography (HIPDM-SPECT) were performed in 16 patients with medically intractable complex partial seizures. Ictal HIPDM-SPECT localized epileptic foci in 13 of 14 patients with unilateral temporal focus and provided confirmative evidence of epileptic focus in 11 patients by demonstrating maximally increased regional cerebral perfusion (rCP) in epileptic foci that had shown decreased rCP in a previous interictal study. Ictal HIPDM-SPECT in two patients with bitemporal foci showed more complicated patterns consisting of slightly increased rCP in bilateral multifocal regions. Ictal HIPDM-SPECT was particularly useful for investigating epileptic foci, and correlation with simultaneously recorded ictal electroencephalograms provided further insight for localizing epileptic foci.
authors.affiliation: Department of Neurology, Indiana University Medical Center, Indianapolis 46223.
authors.forename: B I
authors.initials: BI
authors.lastname: Lee
authors.forename: O N
authors.initials: ON
authors.lastname: Markand
authors.forename: H N
authors.initials: HN
authors.lastname: Wellman
authors.forename: A R
authors.initials: AR
authors.lastname: Siddiqui
authors.forename: H M
authors.initials: HM
authors.lastname: Park
authors.forename: B
authors.initials: B
authors.lastname: Mock
authors.forename: R M
authors.initials: RM
authors.lastname: Worth
authors.forename: M K
authors.initials: MK
authors.lastname: Edwards
authors.forename: J
authors.initials: J
authors.lastname: Krepshaw
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000493:pharmacokinetics; D014055:Tomography, Emission-Computed
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C036739:N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine