title: Validation of PET-acquired input functions for cardiac studies.
abstract: To validate the determination of the arterial input function by noninvasive dynamic PET imaging, measurements of blood-pool activity in canine LV by PET were compared to beta probe measurements of arterial blood withdrawn directly from the LV. PET scans were done during intravenous bolus injections of [13N]ammonia or 82Rb, while the activity of blood withdrawn continuously from a catheter inserted in the LV was measured with a beta probe. PET determinations of LV blood-pool activity were compared with dispersion-corrected beta probe time-activity curves. In 15 experiments involving four dogs under a wide range of physiologic conditions, LV time-activity curves obtained with PET matched well in shape with those obtained with the beta probe. Linear regression yielded slopes within 10% of unity (95% confidence interval) and high correlation (r greater than 0.968, p less than 0.001). We conclude that noninvasive measurement of the arterial input function by dynamic PET imaging is valid.
authors.affiliation: UCLA School of Medicine 90024.
authors.forename: I N
authors.initials: IN
authors.lastname: Weinberg
authors.forename: S C
authors.initials: SC
authors.lastname: Huang
authors.forename: E J
authors.initials: EJ
authors.lastname: Hoffman
authors.forename: L
authors.initials: L
authors.lastname: Araujo
authors.forename: C
authors.initials: C
authors.lastname: Nienaber
authors.forename: M
authors.initials: M
authors.lastname: Grover-McKay
authors.forename: M
authors.initials: M
authors.lastname: Dahlbom
authors.forename: H
authors.initials: H
authors.lastname: Schelbert
mesh_terms: D000641:Ammonia; D000818:Animals; D003326:Coronary Circulation; D004285:Dogs; D009590:Nitrogen Radioisotopes; D012414:Rubidium Radioisotopes; D012588:Scintillation Counting / Q000295:instrumentation; D014055:Tomography, Emission-Computed
chemical_list: D009590:Nitrogen Radioisotopes; D012414:Rubidium Radioisotopes; D000641:Ammonia