Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride.
The (R)-(+)- and (S)-(-)-enantiomers of the anticholinergic compound, oxyphencyclimine, were synthesized from (R)-(-)- and (S)-(+)-2-cyclohexyl-2-hydroxy-2-phenylethanoic acid, respectively. The potencies of the enantiomers were compared using a cholinergic receptor binding assay. The (R)-(+)-enantiomer inhibited binding 29 times more potently than the (S)-(-)-enantiomer.
Schjelderup
L
L
Department of Chemistry, Agricultural University of Norway.
Kozlowski
M R
MR
Weissman
A
A
Aasen
A J
AJ
D000818:Animals; D002417:Cattle; D002540:Cerebral Cortex / Q000378:metabolism; D010276:Parasympatholytics / Q000138:chemical synthesis / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology*; D011813:Quinuclidinyl Benzilate / Q000037:antagonists & inhibitors; D011976:Receptors, Muscarinic / Q000187:drug effects*; D013237:Stereoisomerism
D010276:Parasympatholytics; D011743:Pyrimidines; D011976:Receptors, Muscarinic; C100201:oxyphencyclimine; D011813:Quinuclidinyl Benzilate