[Changes in phospholipid composition of high density lipoproteins in children as a possible precursor of the development of ischemic heart disease].
The proportion of apoprotein-AI (apo-AI) phospholipids (PL) and HDLP phospholipid spectrum were determined in addition to principal coronary risk factors; cholesterol (CS), triglycerides (TG) and high-density lipoprotein (HDLP) CS, in high-risk children, whose parents had survived myocardial infarction at a young age, and also in children with vegetovascular dystonia and a control group. It is demonstrated that children with relatively low percentage of lecithin in HDLP, in the absence of changes in CS, TG, apo-B and apo-AI, and HDLP CS, could be found in all the examined groups, and were particularly numerous in the high-risk group. Correlations coefficients for the HDLP PL percentage in the father-child, mother-child and father-mother pairs were estimated, revealing a positive correlation with respect to lecithin in these pairs, an evidence of the contribution of the general familial environment to the variability of the parameter in question in the examined groups. Different correlations were demonstrated between lecithin/sphingomyelin and lecithin/kephalin ratios in boys and girls from the control and high-risk groups.
Gerasimova
E N
EN
Ozerova
I N
IN
Aingorn
E D
ED
Sipiagina
A E
AE
Belokon'
N A
NA
D000293:Adolescent; D000328:Adult; D002648:Child; D003327:Coronary Disease / Q000209:etiology* / Q000235:genetics; D005260:Female; D006801:Humans; D007009:Hypolipoproteinemias / Q000150:complications* / Q000235:genetics; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000097:blood / Q000172:deficiency*; D012307:Risk Factors; D012737:Sex Factors; D013109:Sphingomyelins / Q000097:blood*
D008075:Lipoproteins, HDL; D010713:Phosphatidylcholines; D013109:Sphingomyelins
Izmenenie fosfolipidnogo sostava lipoproteidov vysokoĭ plotnosti u deteĭ kak vozmozhnyĭ predvestnik razvitiia ishemicheskoĭ bolezni serdtsa.