Effect of 24R,25-dihydroxyvitamin D3 in experimental renal insufficiency.
This placebo-controlled study in JCL-Wistar rats showed that 100 micrograms/kg 24R,25-dihydroxyvitamin D3, when given for 12 days consecutively, restored immune function which had deteriorated following aminonucleoside-induced nephrosis. Urinary creatinine excretion in five-sixths nephrectomized rats was also shown to be increased by 10 micrograms/kg 24R,25-dihydroxyvitamin D3. Hypophosphataemic effects in both these cases of experimentally-induced renal insufficiency was also shown following administration of 24R,25-dihydroxyvitamin D3.
Katoh
T
T
Biomedical Research Laboratories, Kureha Chemical Industry Co., Ltd, Tokyo, Japan.
Maeda
Y
Y
Yamato
H
H
Hirai
T
T
Fujii
T
T
Matsunaga
K
K
Kodaira
T
T
Konai
Y
Y
D015650:24,25-Dihydroxyvitamin D 3; D000818:Animals; D003404:Creatinine / Q000652:urine; D004100:Dihydroxycholecalciferols / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000188:drug therapy*; D008297:Male; D009392:Nephrectomy; D009401:Nephrosis / Q000150:complications / Q000188:drug therapy*; D010710:Phosphates / Q000097:blood / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000187:drug effects
D004100:Dihydroxycholecalciferols; D010710:Phosphates; D015650:24,25-Dihydroxyvitamin D 3; D003404:Creatinine