[Changes in the kallikrein-kinin and complement system in angiography using non-ionic contrast media].
To examine alterations of the kallikrein-kinin system and of the complement due to the bolus injection of newer non-ionic contrast agents, venous blood samples were taken before and 3 min after angiography. There were no adverse contrast reactions clinically evident. Prekallikrein, kallikrein inhibition, beta-factor XIIa inhibition, C1-esterase inhibitor, C1q, C3, ATIII, HMW-kininogen, fibrinogen and factor XII were determined. Bolus injection of the contrast medium caused an activation of the kallikrein-kinin system (p less than 0.05) with reduction of prekallikrein, kallikrein-inhibition, beta-factor XIIa inhibition and C1-esterase inhibitor. The levels of C1q and C3 were also decreased (p less than 0.05) indicating an activation of the complement. Our results demonstrate, that angiography causes a significant activation of the kallikrein-kinin as well as of the complement system in spite of the use of newer non-ionic contrast agents.
Hoffmeister
H M
HM
Medizinische Klinik, Abteilung III, Universität Tübingen.
Fuhrer
G
G
Pirschel
J
J
Heller
W
W
D000792:Angiography; D003166:Complement Activating Enzymes / Q000037:antagonists & inhibitors; D003167:Complement Activation / Q000187:drug effects*; D003174:Complement C1 Inactivator Proteins / Q000097:blood; D015922:Complement C1q; D003176:Complement C3 / Q000037:antagonists & inhibitors; D006801:Humans; D007472:Iohexol / Q000009:adverse effects*; D007479:Iopamidol / Q000009:adverse effects*; D007610:Kallikreins / Q000037:antagonists & inhibitors*; D007705:Kinins / Q000037:antagonists & inhibitors*
D003174:Complement C1 Inactivator Proteins; D003176:Complement C3; D007705:Kinins; D007472:Iohexol; D015922:Complement C1q; D003166:Complement Activating Enzymes; D007610:Kallikreins; D007479:Iopamidol
Veränderungen des Kallikrein-Kinin- und des Komplement-Systems bei Angiographien mit nicht-ionischen Kontrastmitteln.