title: Synthesis of 5,17-dihydroxy-5 alpha, 17 alpha,-19-norpregn-20-yn-3-one, a major photodegradation product of norethindrone.
abstract: A convenient synthesis of 5,17-dihydroxy-5 alpha,17 alpha-19-norpregn-20-yn-3-one in multigram quantities from norethindrone is reported. Confirmation of the structural assignment of this major photodegradation product of norethindrone is thus made.
authors.affiliation: Institute of Organic Chemistry, Syntex Research, Palo Alto, CA 94304.
authors.forename: G F
authors.initials: GF
authors.lastname: Cooper
mesh_terms: D009640:Norethindrone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism*; D010777:Photochemistry
chemical_list: C058988:5,17-dihydroxy-5,17,19-norpregn-20-yn-3-one; D009640:Norethindrone