title: Biotransformation of 1,4-cineole, a monoterpene ether.
abstract: 1. The metabolism of 1,4-cineole, a monoterpene ether, was studied in the rabbit. 2. Four neutral and one acidic metabolites were isolated from the urine and shown to be 9-hydroxy-1,4-cineole, 3,8-dihydroxy-1,4-cineole, 8,9-dihydroxy-1,4-cineole, 1,4-cineole-8-en-9-ol and 1,4-cineole-9-carboxylic acid.
authors.affiliation: Faculty of Pharmaceutical Science, Tokushima Bunri University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Asakawa
authors.forename: M
authors.initials: M
authors.lastname: Toyota
authors.forename: T
authors.initials: T
authors.lastname: Ishida
mesh_terms: D000818:Animals; D001711:Biotransformation; D000081005:Cyclohexane Monoterpenes; D006900:Hydroxylation; D039821:Monoterpenes; D011817:Rabbits; D013729:Terpenes / Q000493:pharmacokinetics*
chemical_list: D000081005:Cyclohexane Monoterpenes; D039821:Monoterpenes; D013729:Terpenes; C058951:1,4-cineole