The effect of N-acetylneuraminic acid on the mucociliary transport impaired by cigarette smoke.
Cigarette smoke exposure impaired the mucociliary transport on the tracheal mucosa of pigeons. N-acetylneuraminic acid (NANA), but not lactose, dose-dependently protected against the impairment of the mucociliary transport. The results suggest that NANA, a representative sialic acid existing on the airway epithelium, may participate the defence mechanism in the respiratory tract against irritant gases.
Miyata
T
T
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Matsumoto
N
N
Yuki
H
H
Takahama
K
K
Okano
Y
Y
Kai
H
H
D000818:Animals; D010856:Columbidae; D005260:Female; D007785:Lactose / Q000494:pharmacology; D008297:Male; D009079:Mucociliary Clearance / Q000187:drug effects*; D012794:Sialic Acids / Q000494:pharmacology*; D012907:Smoking / Q000378:metabolism*; D013997:Time Factors
D012794:Sialic Acids; D007785:Lactose