Expression of Pre-S-encoded proteins in sera of individuals chronically infected with hepatitis D virus.
The sera of 16 individuals chronically infected with the hepatitis D virus were analyzed for hepatitis B virus (HBV) markers. The majority of these patients had a non-replicative form of viral type B hepatitis as indicated by negative tests for HBeAg and HBV-DNA. Pre-S-encoded proteins were detected in 13/16 sera. Sera that were negative for polymerized serum albumin did also not contain pre-S1-encoded proteins. The presence of pre-S-encoded proteins is probably predominantly associated with 22-nm HBsAg forms present in large amounts in sera of individuals with chronic type D hepatitis.
Hess
G
G
I. Medizinische Klinik der Johannes-Gutenberg-Universität Mainz, BRD.
Möller
B
B
Gerken
G
G
Weber
C
C
Manns
M
M
Meyer zum Büschenfelde
K H
KH
D002908:Chronic Disease; D004279:DNA, Viral / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis; D003699:Hepatitis D / Q000097:blood*; D006801:Humans; D011498:Protein Precursors / Q000032:analysis*; D014759:Viral Envelope Proteins / Q000032:analysis*
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D011498:Protein Precursors; D014759:Viral Envelope Proteins; C050806:presurface protein 1, hepatitis B surface antigen; C050807:presurface protein 2, hepatitis B surface antigen