DNA content of T-cell lymphomas. A flow-cytometric analysis.
Paraffin-embedded archival tissue from 29 cases of malignant non-Hodgkin's lymphoma of T-cell type and 9 control lymph nodes were examined by flow cytometry for DNA aneuploidy and cell-cycle kinetics. DNA aneuploidy was detected in 4 cases (13%) and was not related to histologic grade. Proliferative activity, as measured by proliferative index and S-phase fraction, was significantly increased in lymphomas, compared with controls, and was significantly higher in morphologically high-grade lymphomas, compared with low-grade lymphomas and control lymph nodes (P less than 0.05). Different morphologic types of T-cell lymphoma were also significantly different in their proliferative activity P less than 0.05). Moreover, within the category of peripheral T-cell lymphoma, different proliferative rates occurred in tumors in which small cells predominated, compared with intermediate- and large-cell tumors, suggesting biologic differences within this group.
Egerter
D A
DA
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California.
Said
J W
JW
Epling
S
S
Lee
S
S
D000782:Aneuploidy; D002453:Cell Cycle; D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000032:analysis* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000032:analysis; D013601:T-Lymphocytes
D004273:DNA, Neoplasm