title: Encephalitis among Cree children in northern Quebec.
abstract: We report a neurological disease among Cree Indian children in a northern Quebec village. The disease manifests as severe mental retardation, cerebral atrophy with white matter changes and calcifications, and systemic immunological abnormalities. Eleven cases are known in five families. The familial incidence of cases and the high degree of parental consanguinity suggest a genetic contribution. We propose that this entity may be caused by an unusual viral infection in a genetically vulnerable host.
authors.affiliation: Department of Neurogenetics, Montreal Neurological Institute, Quebec.
authors.forename: D N
authors.initials: DN
authors.lastname: Black
authors.forename: G V
authors.initials: GV
authors.lastname: Watters
authors.forename: E
authors.initials: E
authors.lastname: Andermann
authors.forename: C
authors.initials: C
authors.lastname: Dumont
authors.forename: M E
authors.initials: ME
authors.lastname: Kabay
authors.forename: P
authors.initials: P
authors.lastname: Kaplan
authors.forename: K
authors.initials: K
authors.lastname: Meagher-Villemure
authors.forename: J
authors.initials: J
authors.lastname: Michaud
authors.forename: G
authors.initials: G
authors.lastname: O'Gorman
authors.forename: E
authors.initials: E
authors.lastname: Reece
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D001284:Atrophy; D001927:Brain Diseases / Q000209:etiology* / Q000235:genetics / Q000382:microbiology; D002114:Calcinosis / Q000209:etiology* / Q000235:genetics / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D004660:Encephalitis / Q000150:complications / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000209:etiology* / Q000235:genetics / Q000382:microbiology; D008297:Male; D011792:Quebec
chemical_list: D000914:Antibodies, Viral