title: Dose-dependent induction of anti-native DNA antibodies in cats by propylthiouracil.
abstract: Cats receiving propylthiouracil (PTU) develop antinuclear antibodies (ANA) and an immune-mediated disease syndrome characterized by anorexia, lymphadenopathy, weight loss, and Coombs-positive hemolytic anemia. Investigation of the ANA specificity indicated that the predominant ANA activity consistent of anti-native DNA (nDNA) antibodies. The formation of anti-nDNA antibodies and immune-mediated disease syndrome appeared to be dose-dependent, even in cats in which a response had been induced on 4 prior occasions. These results supply further evidence that PTU-induced autoimmunity is not the result of a simple drug allergy. Rather, it appears that PTU induces a lupus-like syndrome, including the hallmark sign of systemic lupus erythematosus, anti-nDNA antibodies.
authors.affiliation: North Carolina State University, School of Veterinary Medicine, Raleigh 27606.
authors.forename: D P
authors.initials: DP
authors.lastname: Aucoin
authors.forename: R L
authors.initials: RL
authors.lastname: Rubin
authors.forename: M E
authors.initials: ME
authors.lastname: Peterson
authors.forename: M M
authors.initials: MM
authors.lastname: Reidenberg
authors.forename: D E
authors.initials: DE
authors.lastname: Drayer
authors.forename: A I
authors.initials: AI
authors.lastname: Hurvitz
authors.forename: R G
authors.initials: RG
authors.lastname: Lahita
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis / Q000276:immunology*; D000918:Antibody Specificity; D002415:Cats; D004247:DNA / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D007154:Immune System Diseases / Q000139:chemically induced; D011441:Propylthiouracil / Q000276:immunology* / Q000494:pharmacology
chemical_list: D000974:Antibodies, Antinuclear; D011441:Propylthiouracil; D004247:DNA