Dietary fish oil reduces intimal proliferation of the coronary artery caused by implantation of a constrictor in pigs.
Piglets received a basal diet to which either lard fat (L) or a mixture of lard fat and mackerel oil (ML) was added. After 2 months a constrictor was placed around the left descending coronary artery (LADCA) and the dietary regimen continued for 2 more months. During the dietary period plasma thromboxane B2 levels, thromboxane B2/6-keto-PGF1 alpha ratio, platelet membrane 20:4 n-6 content and ADP-induced platelet aggregation were all lower in ML than in L. Morphological examination at the site of the LADCA stenosis showed a higher encroachment due to intimal proliferation in L. It is postulated that alterations in eicosanoid synthesis indirectly affected the rate of intimal proliferation.
Lamers
J M
JM
Department of Biochemistry I, Erasmus University, Rotterdam, The Netherlands.
Hartog
J M
JM
Verdouw
P D
PD
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology*; D005395:Fish Oils / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D012016:Reference Values; D013552:Swine; D013929:Thromboxane B2 / Q000097:blood; D014661:Vasoconstriction / Q000187:drug effects*
D005395:Fish Oils; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha