Normalization of high plasma level of ouabain-like immunoreactivity in primary aldosteronism after removal of adenoma.
Plasma ouabain-like immunoreactivity, which has been supposed to be associated with hypertension, was significantly higher in five patients with primary aldosteronism than in age-matched normotensive subjects. High plasma levels of ouabain-like immunoreactivity decreased to normal after removal of adenoma. Extracts of adenoma tissue did not contain any apparent ouabain-like immunoreactivity. Anti-ouabain antibody used in this study did not cross-react with aldosterone, cortisol, corticosterone, arachidonic acid or lysophosphatidylcholine. Hypertension, hypokalemia, a high plasma aldosterone level and low plasma renin activity were also normalized after surgery. These results indicate that hyperaldosteronism induces the high plasma level of ouabain-like immunoreactivity and this is associated in part with high blood pressure (BP) in primary aldosteronism.
Masugi
F
F
Department of Medicine and Geriatrics, Osaka University Medical School, Japan.
Ogihara
T
T
Hasegawa
T
T
Sakaguchi
K
K
Kumahara
Y
Y
D000236:Adenoma / Q000032:analysis / Q000276:immunology / Q000601:surgery*; D000306:Adrenal Cortex Neoplasms / Q000032:analysis / Q000276:immunology / Q000601:surgery*; D000328:Adult; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood* / Q000276:immunology; D008297:Male; D010042:Ouabain / Q000097:blood* / Q000276:immunology; D011184:Postoperative Period; D011863:Radioimmunoassay
D010042:Ouabain