Significance of biological parameters of human blood levels of CoQ10.
Ninety-one men and 143 women who were so-called normal subjects were tested for cardiac performance at rest and their blood levels of co-enzyme Q10 (CoQ10) were determined. In males, a negative relationship between progression of age and cardiac performance, and a positive relationship between progression of age and blood levels of CoQ10 were revealed. In females, a positive relationship between age and blood levels of CoQ10 was found. The mean CoQ10 blood level for both sexes was the same (0.79 +/- 0.20 micrograms/ml for males and 0.79 +/- 0.23 for females). Cardiac performance declines with age in the male population. A decreased biosynthesis and/or incorporation of CoQ10 into mitochondrial structures of muscle cells may occur with age in a normal population.
Komorowski
J
J
Institute for Biomedical Research, University of Texas, Austin 78712.
Muratsu
K
K
Nara
Y
Y
Willis
R
R
Folkers
K
K
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002302:Cardiac Output; D003067:Coenzymes; D005260:Female; D006801:Humans; D008297:Male; D005082:Physical Exertion; D012016:Reference Values; D012737:Sex Factors; D013318:Stroke Volume; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood
D015415:Biomarkers; D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10