[Positron emission tomography using pyruvate-1-11C on mitochondrial encephalomyopathy].
In order to investigate in vivo metabolism of pyruvate in the brain, positron emission tomography (PET) using pyruvate-1-11C were performed on two patients with mitochondrial encephalomyopathy, one patient with Leigh disease and one patient with epilepsy. PET images of epilepsy showed less RI uptakes in brain tissues than in skull muscles. And RI was cleared rapidly from the brain tissues. But PET images of mitochondrial encephalomyopathies showed increased RI uptakes and slow RI clearance in cerebral cortices, basal ganglia and thalamus. Also RI was cleared slowly or accumulated in ventricles. This suggested that pyruvate metabolism may be impaired with metabolical trapping of 11C by lactic acids, since it is said that 11C of pyruvate-1-11C is cleared rapidly from the normal brain tissues by decarboxylation of pyruvate. The usefulness of PET studies with pyruvate-1-11C are suggested for investigating pyruvate metabolism in brain tissues, and for diagnosing mitochondrial encephalomyopathy.
Toyoda
M
M
Department of Pediatric Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
Arai
S
S
Sakuragawa
N
N
Hara
T
T
Iio
M
M
D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007888:Leigh Disease / Q000000981:diagnostic imaging / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000378:metabolism*; D009135:Muscular Diseases / Q000000981:diagnostic imaging / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism*; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D011773:Pyruvates