[Stability of ferricinium cations and their cytostatic effect].
The relative stabilities of different ferricinium cations were studied in buffer or serum-containing solution and in vivo and compared with their cytostatic effects in cultures of Yoshida ascites tumor cells. Although the ferricinium cation itself was the most unstable cation compared with the dimethyl-ferricinium cation and the deuterated ferricinium derivatives it showed the highest cytostatic effect.
Wenzel
M
M
Pharmazeutisches Institut der Freien Universität Berlin.
Wu
Y
Y
Liss
E
E
Neuse
E W
EW
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004355:Drug Stability; D005296:Ferrous Compounds / Q000494:pharmacology; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D000075163:Metallocenes; D051379:Mice; D009942:Organometallic Compounds / Q000494:pharmacology; D012517:Sarcoma, Yoshida / Q000473:pathology
D005296:Ferrous Compounds; D000075163:Metallocenes; D009942:Organometallic Compounds; C050099:1,1'-dimethylferrocene; C004998:ferrocene
Stabilität des Ferricinium-Kations und seine cytostatische Wirkung.