Augmented interleukin-1 production and HLA-DR expression in the synovium of rheumatoid arthritis patients. Possible involvement in joint destruction.
Potent interleukin-1 (IL-1) activity was detected in culture supernatants from synovium, obtained by arthroscopy, from rheumatoid arthritis (RA) patients but not from non-RA patients. Production of IL-1 by RA synovium correlated well with findings of inflammation on arthroscopy and HLA-DR expression in immunohistochemical staining. Furthermore, there was a positive correlation between IL-1 production from RA synovium and joint changes detected on roentgenograms. These findings strongly suggest that IL-1 might play an important role in the joint destruction in RA.
Miyasaka
N
N
Division of Clinical Immunology, Tokyo Women's Medical College, Japan.
Sato
K
K
Goto
M
M
Sasano
M
M
Natsuyama
M
M
Inoue
K
K
Nishioka
K
K
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology; D001706:Biopsy; D005260:Female; D006681:HLA-D Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013583:Synovial Membrane / Q000032:analysis / Q000098:blood supply / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D007375:Interleukin-1