title: Polypodoside A, an intensely sweet constituent of the rhizomes of Polypodium glycyrrhiza.
abstract: Polypodoside A, a novel intensely sweet constituent of the rhizomes of Polypodium glycyrrhiza, was established by spectral and chemical methods as 26-O-alpha-L-rhamnopyranosyl-polypodogenin-3-O-alpha-L-rhamnopyran osyl- (1----2)-beta-D-glucopyranoside [1]. At the doses tested, this isolate was not acutely toxic for mice and was nonmutagenic with Salmonella typhimurium strain TM677. This compound was rated by a human taste panel as exhibiting 600 times the sweetness intensity of a 6% w/v aqueous sucrose solution.
authors.affiliation: Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612.
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: D D
authors.initials: DD
authors.lastname: Soejarto
authors.forename: F A
authors.initials: FA
authors.lastname: Lang
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000818:Animals; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010944:Plants / Q000032:analysis*; D011283:Pregnenes / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D013649:Taste
chemical_list: D006027:Glycosides; D011283:Pregnenes; C058889:polypodoside A