[Anticarcinogenic and antitumor properties of selenium-containing phenol derivatives].
Certain derivatives of phenolselenonic acid, namely ammonium, calcium, potassium, and sodium 3-acetoxy-4-methoxybenzolselenonates as well as the corresponding derivatives of 3-hydroxy-4-methoxybenzolselenonic acid were studied. These compounds were tested for anticarcinogenic activity against urethane-induced pulmonary adenomas and for antitumoral activity against some transplanted tumours such as leukemia L 1210, mammary adenocarcinoma Ca 755 and Walker carcinosarcoma 256. These compounds were found to produce more intensive anticarcinogenic action than antitumoral one. The results showed that ammonium 3-acetoxy-4-methoxybenzolselenonate given before the injection of urethane or together with urethane exert a significant influence on adenomas, while calcium 3-hydroxy-4-methoxybenzolselenonate inhibited the formation of adenomas at various stages of their development.
Didzhiapetrene
Ia K
IaK
Shukialene
D F
DF
Dzhiuvene
D A
DA
Degutis
Iu A
IuA
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy; D010636:Phenols / Q000627:therapeutic use*; D051381:Rats; D012643:Selenium / Q000627:therapeutic use*; D013997:Time Factors; D014520:Urethane
D000970:Antineoplastic Agents; D010636:Phenols; D014520:Urethane; D012643:Selenium
Antikantserogennye i protivoopukholevye svoĭstva nekotorykh selensoderzhashchikh proizvodnykh fenolov.