title: Ceramic systems for long-term delivery of chemicals and biologicals.
abstract: Evaluation of devices, drugs, and drug delivery systems have been investigated by both in vitro and in vivo procedures. Ceramic drug delivery systems can be used to evaluate chemicals and biologicals by both in vitro and in vivo procedures. The system can also reduce handling of the animals and facilitate long-term evaluations before conducting clinical trials. To date, ceramic systems have been used to deliver aldosterone, androstanedione, beta-lactoglobulin, bovine serum albumin, chymotrypsin, danazol, difluoromeythylornithine, dihydrotestosterone, estradiol, gamma globulin, gonadotrophic releasing hormone, gossypol, growth hormone, insulin, methylene blue, pepsin, progesterone, and testosterone. The data obtained suggest that ceramic delivery systems can be used in the near future to treat diseases requiring long-term chronic drug therapy as well as disorders caused by deficiency of certain hormones.
authors.affiliation: Department of Biology, University of Dayton, Ohio 45469.
authors.forename: P K
authors.initials: PK
authors.lastname: Bajpai
authors.forename: H A
authors.initials: HA
authors.lastname: Benghuzzi
mesh_terms: D000315:Adrenalectomy; D000535:Aluminum / Q000032:analysis; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D001923:Brain Chemistry; D002118:Calcium; D017610:Calcium Compounds; D002516:Ceramics; D003345:Corticosterone / Q000097:blood; D004343:Drug Implants; D006072:Gossypol / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D006728:Hormones / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D010087:Oxides; D010758:Phosphorus; D017553:Phosphorus Compounds; D051381:Rats; D012016:Reference Values; D013089:Spermatocidal Agents / Q000493:pharmacokinetics; D013256:Steroids / Q000097:blood / Q000493:pharmacokinetics*; D013739:Testosterone / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D001798:Blood Proteins; D017610:Calcium Compounds; D004343:Drug Implants; D006728:Hormones; D010087:Oxides; D017553:Phosphorus Compounds; D013089:Spermatocidal Agents; D013256:Steroids; D010758:Phosphorus; D013739:Testosterone; C012500:phosphorus pentoxide; C016538:lime; D000535:Aluminum; D006072:Gossypol; C028178:gossypol acetic acid; D002118:Calcium; D003345:Corticosterone