title: Dysarthria after large doses of intravenous diazepam.
abstract: This is a description of a 34-month-old girl with dysarthria after a dosage of 37.5 mg/15 hours of intravenous diazepam (DZP). Dysarthria lasted 180 hours after the final dose. However, her respiration and blood pressure were normal, and disturbance of consciousness was mild and normalized at 77 hours. The clinical correlations of the concentrations of DZP and its active metabolite are discussed.
authors.affiliation: Department of Pediatrics, Nagoya City University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.forename: M
authors.initials: M
authors.lastname: Hato
authors.forename: A
authors.initials: A
authors.lastname: Tauchi
authors.forename: Y
authors.initials: Y
authors.lastname: Wada
mesh_terms: D001143:Arousal / Q000187:drug effects; D002675:Child, Preschool; D003975:Diazepam / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004401:Dysarthria / Q000139:chemically induced*; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D011183:Postoperative Complications / Q000188:drug therapy*; D013064:Speech Disorders / Q000139:chemically induced*
chemical_list: D003975:Diazepam