title: Relation between individual and ensemble release kinetics of indomethacin from microspheres.
abstract: Indomethacin microspheres based on a combination of ethylcellulose and polyethyleneglycol were prepared using the solvent evaporation process. Release profiles of ensemble and individual microspheres were measured. Both were found to follow first-order kinetics, in contrast to what was expected. This was attributed to the fact that all the particles showed the same kinetic pattern and had a greater degree of homogeneity in the payload, mean particle size and shape, and k1 values than in ensembles of microcapsules.
authors.affiliation: Department of Pharmacy, School of Pharmacy, Hebrew University of Jerusalem, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Benita
authors.forename: D
authors.initials: D
authors.lastname: Babay
authors.forename: A
authors.initials: A
authors.lastname: Hoffman
authors.forename: M
authors.initials: M
authors.lastname: Donbrow
mesh_terms: D007213:Indomethacin / Q000493:pharmacokinetics*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size
chemical_list: D007213:Indomethacin