[Secretory gastric function and the development of reflux esophagitis in peptic ulcer].
129 patients with peptic ulcer in the acute stage of the disease were studied clinically, roentgenologically, endoscopically and morphologically. The patients were classified into two groups--with or without dyspeptic syndrome. The gastric acidity was examined by the fractionary titration method with pentagastrin as stimulant, Reflux-esophagitis was found in patients with hyperacidity as well as in patients with normal and hypoacidity. The destructive changes in the esophageal epithelium were more frequent in the patients with duodenal ulcer--12.9% than in the patients with gastric ulcer. The reflux-esophagitis was found three times less in the patients with peptic ulcer without dyspeptic syndrome than in the patients with peptic ulcer with dyspeptic syndrome, without reliable differences in the secretory indices between the two groups. The conclusion is made that the gastric acidity without functional disorders in the gastroesophageal segment is not a decisive factor in the development of the dyspeptic syndrome in peptic ulcer.
Simitchiev
S
S
Bodurov
I
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D004381:Duodenal Ulcer / Q000150:complications* / Q000503:physiopathology; D004724:Endoscopy; D004942:Esophagitis, Peptic / Q000209:etiology* / Q000503:physiopathology; D004947:Esophagus / Q000473:pathology; D005260:Female; D005336:Fiber Optic Technology; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D013276:Stomach Ulcer / Q000150:complications* / Q000503:physiopathology
Sekretorna stomashna funktsiia i razvitie na refluks-ezofagit pri iazvena bolest.