A circulating thyroid peroxidase-like substance in healthy human peripheral blood.
Circulating thyroid peroxidase (TPO)-like substance in healthy human peripheral blood was studied to clarify the immunological role of TPO. By using a highly sensitive radioimmunoassay system combined with murine monoclonal antibodies, TPO-like substance was measurable in 6 out of 84 sera. Characterization of this circulating substance by gel filtration revealed that the molecular weight of a major peak corresponded to that of trypsinized TPO. From these findings it is possible that peripheral blood lymphocytes are exposed to a low level of TPO as well as to thyroglobulin.
Kotani
T
T
Central Laboratory of Clinical Investigation, Miyazaki Medical College Hospital, Japan.
Ohtaki
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S
D000328:Adult; D000911:Antibodies, Monoclonal; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000097:blood* / Q000145:classification; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D000911:Antibodies, Monoclonal; D007453:Iodide Peroxidase