title: Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-beta.
abstract: Transforming growth factor-beta (TGF-beta) inhibits proliferation of Nb2 cells, a rat T lymphoma, in response to lactogens and interleukin-2. Prostaglandins may play an important role in the pathway through which TGF-beta exerts its inhibitory actions, because prostaglandin E2 also inhibits proliferation of Nb2 cells, and indomethacin, an inhibitor of prostaglandin synthesis, reverses the inhibitory effects of TGF-beta on Nb2 cell proliferation.
authors.affiliation: Department of Life Sciences, Indiana State University, Terre Haute.
authors.forename: E J
authors.initials: EJ
authors.lastname: Rayhel
authors.forename: D A
authors.initials: DA
authors.lastname: Prentice
authors.forename: P S
authors.initials: PS
authors.lastname: Tabor
authors.forename: W H
authors.initials: WH
authors.lastname: Flurkey
authors.forename: R W
authors.initials: RW
authors.lastname: Geib
authors.forename: R F
authors.initials: RF
authors.lastname: Laherty
authors.forename: S B
authors.initials: SB
authors.lastname: Schnitzer
authors.forename: R
authors.initials: R
authors.lastname: Chen
authors.forename: J P
authors.initials: JP
authors.lastname: Hughes
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D015232:Dinoprostone; D013006:Growth Hormone / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology; D008223:Lymphoma / Q000473:pathology*; D010455:Peptides / Q000494:pharmacology*; D011388:Prolactin / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D013601:T-Lymphocytes / Q000187:drug effects; D015291:Transforming Growth Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D007376:Interleukin-2; D010455:Peptides; D011453:Prostaglandins; D011458:Prostaglandins E; D015291:Transforming Growth Factors; D011388:Prolactin; D013006:Growth Hormone; D015232:Dinoprostone; D007213:Indomethacin