Wiskott-Aldrich syndrome in identical twins: abnormality of CD4 and CD8 positive lymphocytes.
The rare occurrence of Wiskott-Aldrich syndrome (WAS) in identical twin brothers without a preceding family history of the disease is described. Investigation into the nature of the lymphocyte abnormality in the surviving twin suggests that the frequency of T cell clone forming cells is markedly decreased. Further analysis of the T cell clones showed a deficiency of CD8 positive cytotoxic/suppressor cells. This alteration may be an underlying mechanism in the development of some of the clinical manifestations of WAS.
Forsyth
K
K
Flinders Medical Centre, SA.
Seshadri
R
R
Matthews
C
C
Heddle
R
R
D000911:Antibodies, Monoclonal; D002999:Clone Cells / Q000276:immunology; D004200:Diseases in Twins; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010641:Phenotype; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D014430:Twins, Monozygotic; D014923:Wiskott-Aldrich Syndrome / Q000276:immunology*
D000911:Antibodies, Monoclonal