Augmentation and stable expression of a novel transcription factor SII in CD4-positive cells on infection with human immunodeficiency virus type-1 (HIV-1).
We have examined the expression of a novel transcription factor SII in HIV-infected cells. Concomitant with the increasing expression of HIV-1 mRNA, the viability of HIV infected cells dropped and the expression of beta-actin gene also diminished. Concurrently, the expression of SII mRNA was stabilized or augmented. The data presented in this communication suggests that in HIV-1 infected cells, selective transcriptional controls were taking place and that a novel transcriptional factor, SII, plays an essential role in HIV-1 expression leading to cytocidal effects.
Hamamoto
Y
Y
Department of Virology and Parasitology, Yamaguchi University School of Medicine, Japan.
Hirashima
S
S
Natori
S
S
Yamamoto
N
N
Kobayashi
N
N
D000199:Actins / Q000235:genetics; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D002470:Cell Survival / Q000187:drug effects; D004591:Electrophoresis, Polyacrylamide Gel; D005786:Gene Expression Regulation; D015490:HTLV-I Infections / Q000235:genetics* / Q000378:metabolism; D015368:Human T-lymphotropic virus 1 / Q000235:genetics; D006801:Humans; D012333:RNA, Messenger / Q000378:metabolism; D012367:RNA, Viral / Q000378:metabolism; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics; D035165:Transcription Factors, General; D014158:Transcription, Genetic; D035602:Transcriptional Elongation Factors
D000199:Actins; D000945:Antigens, Differentiation, T-Lymphocyte; D012333:RNA, Messenger; D012367:RNA, Viral; D014157:Transcription Factors; D035165:Transcription Factors, General; D035602:Transcriptional Elongation Factors; C018648:transcription factor S-II