Multiple organ failure during interleukin-2 administration and LAK cells infusion.
Adoptive immunotherapy is a new promising treatment for cancer but is associated with severe toxicity mainly related to a capillary leak syndrome. We report the case of a patient with metastatic hypernephroma, who had many complications such as coma, renal failure, pulmonary edema, life-threatening acidosis, cardiac arrhythmias and venous thrombosis. Critical care specialists should be aware of this type of cancer therapy because of multiple side effects requiring ICU supportive care.
Sculier
J P
JP
Service de Médecine, Institut Jules Bordet, Centre des Tumeurs de l'Université, Libre de Bruxelles, Belgium.
Bron
D
D
Verboven
N
N
Klastersky
J
J
D001859:Bone Neoplasms / Q000556:secondary / Q000628:therapy; D006801:Humans; D007376:Interleukin-2 / Q000008:administration & dosage / Q000009:adverse effects*; D007694:Killer Cells, Natural / Q000637:transplantation*; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy; D008222:Lymphokines / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000139:chemically induced*
D007376:Interleukin-2; D008222:Lymphokines