Influence of age on epidermal growth factor receptor level in the rat brain.
The influence of age on 125I-epidermal growth factor (EGF) binding to rat brain plasma membranes was investigated. The specific binding of EGF to membranes decreased gradually with age in both male and female rats. There was no significant difference in the specific binding between males and females. Scatchard analysis of the binding data showed that the decrease in EGF binding with age was due to a decrease in the number of EGF receptors.
Hiramatsu
M
M
Department of Dental Pharmacology, Josai Dental University, Saitama, Japan.
Kashimata
M
M
Sato
A
A
Murayama
M
M
Minami
N
N
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004815:Epidermal Growth Factor; D066246:ErbB Receptors