Rapid urease test provides specific identification of Campylobacter pylori in antral mucosal biopsies.
In a prospective study, three antral biopsies were taken from 175 dyspeptic patients during routine endoscopy. One biopsy was inserted immediately into a gel-containing well of a CLOtest slide and two biopsies were sent to histopathology. Using the CLOtest, 84 of the 175 samples (48%) detected urease activity in the gastric biopsy, suggesting infection with Campylobacter pylori. Histopathological examination by two independent observers reported that 93 (52%) of the biopsies contained Campylobacter-like organisms. The CLOtest was found to have a specificity of 1.0 and sensitivity of 0.91, providing a rapid identification of most patients harbouring the organism in their gastric mucus.
Szeto
M L
ML
Academic Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
Pounder
R E
RE
Hamilton-Dutoit
S J
SJ
Dhillon
A P
AP
D001706:Biopsy; D002167:Campylobacter / Q000201:enzymology / Q000302:isolation & purification*; D005753:Gastric Mucosa / Q000382:microbiology*; D006801:Humans; D009092:Mucous Membrane / Q000382:microbiology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D014510:Urease / Q000032:analysis*
D014510:Urease