Effect of nifedipine on the shuttlebox escape deficit induced by inescapable shock in the rat.
The behavioural effect of subchronic treatment with calcium channel antagonists (nifedipine, verapamil) and with imipramine was assessed in rats subjected to inescapable shock (IS). The effect of subchronic treatment with nifedipine and imipramine on specific [3H]nitrendipine ([3H]NDP) binding was investigated in frontal cortex of naive rats and in rats given IS then tested for shuttlebox escape. The rats showed a severe impairment in escape behaviour after IS. Imipramine and nifedipine significantly reduced FR1 and FR2 escape deficits. Verapamil had no effect. A small but significant increase in the number of [3H]NDP binding sites (Bmax) was seen in rats exposed to the shuttlebox escape test independent of a previous exposure to IS. Imipramine had no influence on Bmax in any of the groups. Nifedipine did not affect [3H]NDP binding in naive rats but decreased Bmax in rats subjected to IS and the shuttlebox escape test. The comparable ability of nifedipine and imipramine to reverse the shuttlebox escape deficit induced by IS argues for a possible antidepressant activity of nifedipine. The biochemical data indicate that cortical [3H]NDP binding sites are not correlated to performance in the shuttlebox escape test.
Geoffroy
M
M
Psychopharmacological Research Laboratory, Sct. Hans Hospital, Roskilde, Denmark.
Mogilnicka
E
E
Nielsen
M
M
Rafaelsen
O J
OJ
D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003863:Depression / Q000378:metabolism; D004597:Electroshock; D004924:Escape Reaction / Q000187:drug effects* / Q000502:physiology; D007099:Imipramine / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D009568:Nitrendipine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000494:pharmacology
D009568:Nitrendipine; D014700:Verapamil; D009543:Nifedipine; D007099:Imipramine