title: T-cell acute lymphoblastic leukemia with translocation (1;18).
abstract: A case of T-cell acute lymphoblastic leukemia with a translocation between chromosomes #1 and #18 is described. The breakpoints were at bands 1q23 and 18q21. A single cell contained the translocation t(1;19)(q23;p13). The breakpoint on chromosome #1 was the same in both translocations, and the breakpoint on chromosome #18 was the same as that in t(14;18)(q32;q21) associated with follicular lymphoma. The possible relationship between chromosome bands 1q23 and 18q21 and the morphologic features of the leukemia cells is discussed.
authors.affiliation: Department Oncology-Hematology, Medical University Clinic, Hamburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Suciu
authors.forename: H J
authors.initials: HJ
authors.lastname: Weh
authors.forename: D K
authors.initials: DK
authors.lastname: Hossfeld
mesh_terms: D000293:Adolescent; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002887:Chromosomes, Human, Pair 18; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics*; D013601:T-Lymphocytes; D014178:Translocation, Genetic
chemical_list: D005819:Genetic Markers