Infectious episodes following diphtheria-pertussis-tetanus vaccination. A preliminary observation in infants.
Eighty two infants, aged 2-12 months, were prospectively studied for infectious episodes following diphtheria-pertussis-tetanus (DPT) immunization. The occurrence of infectious episodes during the month following vaccination was compared to that during the month prior to its administration. The 3 days following vaccination were not included. In comparison to the month prior to immunization, during the month following there were significantly more infants with fever (6.1% vs. 24.4%, p less than 0.001), with diarrhea (7.3% vs. 23.1%, p less than 0.005), and with cough (37.7% vs. 52.4% p N.S.). After the first month of the study, there was an increase in morbidity in the region, so we reevaluated those cases who had been seen during the latter 3 months. The same trend was found: in the month following immunization there were significantly more infants with fever (5.3% vs. 25%, p less than 0.005), with diarrhea (10.5% vs. 28%, p less than 0.02), and with cough (26% vs. 54%, p less than 0.01). There was no correlation between the incidence of these episodes and the age at vaccination. In addition to reactive fever during the first 3 days following DPT immunization, an increase in infectious episodes seems to occur in infants during the month following administration of this vaccine.
Jaber
L
L
Department of Pediatrics, Beilinson Medical Center, Petah Tiqva, Israel.
Shohat
M
M
Mimouni
M
M
D003141:Communicable Diseases / Q000453:epidemiology*; D004168:Diphtheria Toxoid / Q000009:adverse effects*; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004198:Disease Susceptibility; D004338:Drug Combinations / Q000009:adverse effects; D005260:Female; D006801:Humans; D007223:Infant; D007557:Israel; D008297:Male; D010567:Pertussis Vaccine / Q000009:adverse effects*; D011446:Prospective Studies; D012621:Seasons; D013745:Tetanus Toxoid / Q000009:adverse effects*
D004168:Diphtheria Toxoid; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid