Alterations in hypothalamic serotonergic-catecholaminergic relationships in aging C57BL/6J female mice.
The effects of aging and estradiol on the three major hypothalamic monoaminergic systems were measured in female C57BL/6J mice. Both aging and estradiol treatment induced small (10-15%) changes in the levels and ratios of the monoamines and their catabolites. In addition, the levels of 5-hydroxyindoleacetic acid, the major serotonergic catabolite, were strongly correlated with the levels of the two major dopaminergic catabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid. Aging affected the relationship between 5-hydroxyindoleacetic acid and the dopaminergic catabolites such that the slope of the regression lines of 5-hydroxyindoleacetic acid on the dopaminergic compounds was increased in older mice. The age-related alteration in the correlations between the serotonergic and dopaminergic compounds may be due to an effect of aging on the acid export system.
Telford
N
N
Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191.
Mobbs
C V
CV
Osterburg
H H
HH
Finch
C E
CE
D000375:Aging / Q000378:metabolism*; D000818:Animals; D015306:Biogenic Monoamines / Q000032:analysis*; D002396:Catechols / Q000032:analysis; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007031:Hypothalamus / Q000032:analysis*; D007211:Indoles / Q000032:analysis; D051379:Mice; D008810:Mice, Inbred C57BL
D015306:Biogenic Monoamines; D002396:Catechols; D007211:Indoles; D004958:Estradiol