Pharmacokinetics and renal accumulation of three iodinated contrast agents. A comparative study of Telebrix, Hexabrix and Omnipaque in the rabbit.
Male and female New Zealand rabbits were given a single bolus injection of 5 ml/kg of Telebrix, Hexabrix or Omnipaque intravenously. Animals were sacrificed 2, 8 and 24 h after the injection. One group of animals received a continuous i.v. infusion of contrast medium at a constant rate of 2.5 ml/kg/h for 4 h. Animals from this group were killed 30 min after the end of the infusion. Product clearance from plasma was studied in the animals given the i.v. bolus of contrast material and sacrified at 24 h postinjection. Plasma and tissue concentrations of contrast material were determined by high-performance liquid chromatography. Plasma elimination half-lives were identical in males and females and for all three products (approximately 45 min). The same held true for the volume of distribution which comprised between 20 and 26% of body weight. At 2 h postinjection, renal cortical concentrations of contrast medium were 8 to 10 times higher than plasma concentrations. For all three contrast agents, concentrations found in the renal cortex were higher than those in the medulla or the papilla at all observation times. As compared with the evolution of plasma concentrations over time, renal accumulation of the products was found to be persistent. The ionic or non-ionic nature of the tested products and their hydrophilic properties seem to play an essential role in the renal accumulation pattern.
Morin
J P
JP
I.N.S.E.R.M. U-295, University of Rouen, France.
Boutelet
I
I
Toutain
H
H
Fillastre
J P
JP
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003287:Contrast Media / Q000493:pharmacokinetics*; D005260:Female; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D007472:Iohexol / Q000493:pharmacokinetics*; D007483:Iothalamic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D007485:Ioxaglic Acid / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D011817:Rabbits
D003287:Contrast Media; D007483:Iothalamic Acid; D007472:Iohexol; C002587:ioxitalamic acid; D007485:Ioxaglic Acid