Levels of erythromycin in tear fluid and serum in infants with conjunctivitis.
38 newborns with purulent conjunctivitis were treated with oral erythromycin ethylsuccinate 25 mg/kg every 12 h for 14 days. 3-4 days after initiation of therapy, erythromycin levels in serum and tear fluid were measured 1 and 12 h after the administration of erythromycin. The level of erythromycin in tear fluid was significantly higher than that in serum 1 and 12 h after administration of the antibiotic. On both occasions the concentrations of erythromycin in tear fluid and in serum exceeded the minimum inhibitory concentration (MIC) in vitro for Chlamydia trachomatis.
Sandström
I
I
Department of Ophthalmology, Karolinska Institute, Stockholm, Sweden.
Ringertz
O
O
D002692:Chlamydia trachomatis / Q000187:drug effects; D003234:Conjunctivitis, Bacterial / Q000188:drug therapy* / Q000378:metabolism; D003235:Conjunctivitis, Inclusion / Q000188:drug therapy* / Q000378:metabolism; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000627:therapeutic use; D015643:Erythromycin Ethylsuccinate; D006801:Humans; D007231:Infant, Newborn; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000378:metabolism; D013211:Staphylococcus aureus / Q000187:drug effects; D013666:Tears / Q000032:analysis*; D013997:Time Factors
D015643:Erythromycin Ethylsuccinate; D004917:Erythromycin