[Endocrine mechanisms of a delay in the onset of sexual maturity in female rats after neonatal exposure to cortisol].
A study was made of the effect of neonatal cortisol treatment on maturity development, ontogenesis of the secretion of estradiol by the endocrine glands and its reception in the uterine cytosol in female rats. This treatment caused a considerable delay of the vaginal opening and the onset of the first estrus. An increase in estradiol secretion by the adrenal glands was observed in maturing rats of the study group. Estradiol secretion by the ovaries was not greatly changed. Neonatal cortisol treatment did not influence the development of estradiol reception in the uterine cytosol either. It was assumed that sex developmental disturbance was associated with estradiol hypersecretion by the adrenal glands.
Tinnikov
A A
AA
Bazhan
N M
NM
Ivanova
L N
LN
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism; D000375:Aging / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011959:Receptors, Estradiol / Q000187:drug effects / Q000378:metabolism; D012741:Sexual Maturation / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism
D011959:Receptors, Estradiol; D004958:Estradiol; D006854:Hydrocortisone
Endokrinnye mekhanizmy zaderzhki nastupleniia polovoĭ zrelosti u krys-samok posle neonatal'nogo vozdeĭstviia kortizolom.