[Pharmacological analysis of the participation of serotonin in the central mechanisms of the development of a neurogenic stomach lesion in the rat].
The involvement of the central serotoninergic structures in the development of neurogenic gastric lesions caused by a 3-hour electrostimulation of immobilized rats was shown. D,L-5-hydroxytryptophan exerted no protective effect on the formation of destructive lesions of the gastric mucosa. Deseril and BC-15 (Pizotifen, Sandomigran) significantly reduced the formation of hemorrhagic erosions and prevented a decrease of serotonin and noradrenaline levels and creatine phosphate content in the brain tissue.
Bul'on
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VV
D006916:5-Hydroxytryptophan / Q000627:therapeutic use; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D008297:Male; D008784:Methysergide / Q000627:therapeutic use; D010918:Pizotyline / Q000627:therapeutic use; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D012149:Restraint, Physical; D012701:Serotonin / Q000502:physiology*; D013272:Stomach Diseases / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control
D011985:Receptors, Serotonin; D010918:Pizotyline; D012701:Serotonin; D006916:5-Hydroxytryptophan; D008784:Methysergide
Farmakologicheskiĭ analiz uchastiia serotonina v tsentral'nykh mekhanizmakh razvitiia neĭrogennogo povrezhdeniia zheludka krys.