Correlated ultrastructural and immunological findings in CD8+ and CD4+ peripheral T-cell lymphomas.
Ultrastructural features of CD8+ and CD4+ peripheral T-cell lymphomas were studied and the results revealed distinct traits correlated with phenotype. CD8+ peripheral T-cell lymphomas were characterized by a rich organular pattern with a well-developed Golgi apparatus, dense granules, numerous and atypical giant mitochondria. CD4+ peripheral T-cell lymphomas were characterized by wide cytoplasmic areas devoid of organelles. Since similar ultrastructural features differentiated normal and pathological CD8+ and CD4+ peripheral T-lymphocytes, we conclude that under both normal and pathological conditions the expression on the part of the peripheral T-lymphocytes of CD8+ and CD4+ phenotypes is associated to morphological features which distinguish the two subsets.
Osculati
F
F
Istituto di Anatomia Umana ed Istologia, Università di Verona, Italy.
Cinti
S
S
Reynès
M
M
Balercia
G
G
Canon
C
C
Tricottet
V
V
Dantchev
D
D
Mathé
G
G
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis / Q000276:immunology; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000276:immunology / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010641:Phenotype; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology / Q000648:ultrastructure
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte