Autoregulation of testicular LH receptors in Ames dwarf (df/df) and pigmy (pg/pg) mice.
The autoregulation of testicular LH receptors was studied in mutant mice with congenital PRL and GH deficiency (df/df) and in mutant mice with congenital resistance to GH (pg/pg). Low dose of hCG produced an increase in LH receptors in df/df mice, but not in normal mice of the same strain. Intermediate doses of hCG did not affect LH receptors in df/df mice, while decreasing them in normal mice. In pg/pg mice, hCG caused changes in LH receptors which were identical to those observed in their normal siblings. Comparison of these two mutations suggests a lack of involvement of GH in the regulation of testicular LH receptors. Moreover, results obtained from df/df mice could indicate the presence of direct effects of the df mutation on testicular LH receptors.
Amador
A G
AG
Department of Physiology, School of Medicine, Southern Illinois University, Carbondale 62901-6512.
Bartke
A
A
Beamer
W G
WG
Siler-Khodr
T M
TM
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D013006:Growth Hormone / Q000502:physiology*; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D011388:Prolactin / Q000502:physiology*; D011974:Receptors, LH / Q000502:physiology*; D013737:Testis / Q000502:physiology*; D013739:Testosterone / Q000097:blood
D006063:Chorionic Gonadotropin; D011974:Receptors, LH; D013739:Testosterone; D011388:Prolactin; D013006:Growth Hormone