[The effect of acetoacetate on 3-hydroxybutyrate oxidation by rat liver mitochondria].
Effect of acetoacetate on 3-hydroxybutyrate oxidation by rat liver mitochondria is described. State 3 respiration is inhibited by acetoacetate, while state 4 respiration is not inhibited, though cytochrome c reduction was decreased. Acetoacetate is also non-competitive inhibitor of 3-hydroxybutyrateoxidase and 3-hydroxybutyrate dehydrogenase activity in frozen-thawed mitochondria. The results are discussed in terms of the thermodynamic hypothesis and control strength method.
Koshkin
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D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates / Q000494:pharmacology*; D000818:Animals; D006884:Hydroxybutyrate Dehydrogenase / Q000037:antagonists & inhibitors; D006885:Hydroxybutyrates / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008930:Mitochondria, Liver / Q000201:enzymology / Q000378:metabolism*; D010084:Oxidation-Reduction; D010085:Oxidative Phosphorylation / Q000187:drug effects; D051381:Rats
D000090:Acetoacetates; D006885:Hydroxybutyrates; D006884:Hydroxybutyrate Dehydrogenase; D020155:3-Hydroxybutyric Acid
Vliianie atsetoatsetata na okislenie 3-oksibutirata mitokhondriiami pecheni krys.