title: Cell metabolism response to cardiopulmonary bypass in patients undergoing aorto-coronary grafting.
abstract: The main parameters of muscle acid-base, water and energy metabolism were studied in ten patients undergoing low-flux (1.5 l/min/m2), low-pressure (40 to 60 mmHg) hypothermic (26 degrees C) cardiopulmonary bypass (CPB) for aortocoronary grafting; absolute gas exchange and haemodynamic data were also measured throughout the entire CPB period. At the end of CPB a substantial preservation of water and energy metabolic indexes was found; a condition of extracellular metabolic acidosis was apparently sustained by muscle cell anaerobic glycolysis enhancement with a consequent increase of both muscle and plasma lactate content. Subnormal cell phosphocreatine levels as well as reduced bicarbonate buffer stores and decreased intracellular pH, were detected. Direct limiting effects of hypothermia on tissue O2 delivery and muscle oxidative metabolism as well as vasoconstriction and arteriovenous shunting associated with CPB procedures are likely to be involved in the above mentioned alterations of cell metabolism.
authors.affiliation: Istituto di Clinica Medica e Nefrologia, Università di Parma, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Del Canale
authors.forename: E
authors.initials: E
authors.lastname: Fiaccadori
authors.forename: A
authors.initials: A
authors.lastname: Vezzani
authors.forename: L
authors.initials: L
authors.lastname: Belli
authors.forename: D
authors.initials: D
authors.lastname: Medici
authors.forename: E
authors.initials: E
authors.lastname: Coffrini
authors.forename: N
authors.initials: N
authors.lastname: Ronda
authors.forename: P
authors.initials: P
authors.lastname: Vitali
authors.forename: A
authors.initials: A
authors.lastname: Guariglia
authors.forename: F
authors.initials: F
authors.lastname: Fesani
mesh_terms: D000136:Acid-Base Equilibrium; D000140:Acidosis, Lactic / Q000209:etiology*; D000255:Adenosine Triphosphate / Q000378:metabolism; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D010101:Oxygen Consumption; D010725:Phosphocreatine / Q000378:metabolism; D014882:Water-Electrolyte Balance
chemical_list: D010725:Phosphocreatine; D000255:Adenosine Triphosphate