title: Resting lymphocytes are the target of cyclosporin action.
abstract: Immunomodulation with Cyclosporin may allow better management of the patient with insulin dependent diabetes mellitus. The cellular effects of CsA were determined on rabbit lymphocytes which are a resting (Go) population for which the kinetics of activation have been defined. Cyclosporin inhibited polyclonal T-cell activation as well as B-cell activation by T-dependent and T-independent antigens. Resting lymphocytes were the exclusive target of CsA. Primed or activated cells, as well as cells in G1, were resistant to the drug. Cyclosporin inhibited the generation of T-helper cells and spared suppressor cell generation. The inhibitory effects of cyclosporin were not reversible.
authors.affiliation: Department of Pathology, University of Texas Health Science Center, Houston 77030.
authors.forename: P M
authors.initials: PM
authors.lastname: Kimball
authors.forename: N
authors.initials: N
authors.lastname: Gamaz
authors.forename: S
authors.initials: S
authors.lastname: Sell
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001402:B-Lymphocytes / Q000276:immunology; D003524:Cyclosporins / Q000494:pharmacology*; D004261:DNA Replication; D007074:Immunoglobulin G / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D003524:Cyclosporins; D007074:Immunoglobulin G