[Change in the composition of phospholipids and antioxidative activity of lipids of mouse organs after administration of adriamycin].
The phospholipid composition and the antioxidative activity (AOA) of lipids from liver, heart and brain of F1(CBA X C57Bl) mice change significantly after intraperitoneal injection of adriamycin (7 mg/kg). All tissues studied are characterized by a drastic fall in the phosphatidylethanolamine (PEA) content and the AOA of lipids with a minimum on the 2nd-4th days and a subsequent return to normal values on the 10th-14th days. These results are consistent with the hypothesis on the intensification of adriamycin-induced lipid peroxidation and the predominant expenditure of readily oxidized phospholipids, including PEA.
Pal'mina
N P
NP
Dzhaparova
A A
AA
Gaintseva
V D
VD
Burlakova
E B
EB
D000818:Animals; D001921:Brain / Q000378:metabolism; D004317:Doxorubicin / Q000494:pharmacology*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity; D010084:Oxidation-Reduction; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010743:Phospholipids / Q000032:analysis*
D010714:Phosphatidylethanolamines; D010743:Phospholipids; D004317:Doxorubicin
Izmenenie sostava fosfolipidov i antiokislitel'noĭ aktivnosti lipidov organov mysheĭ posle vvedeniia adriamitsina.