title: Structure-activity relationships for non-steroidal inhibitors of aromatase.
abstract: A model is described for the binding of non-steroidal inhibitors of aromatase to the enzyme with interaction of a ligand with the Fe3+-haem of the cytochrome. The model suggests that the inhibitors utilise a common binding site with ring A of the steroidal substrates.
authors.affiliation: Welsh School of Pharmacy, Cardiff, U.K.
authors.forename: L
authors.initials: L
authors.lastname: Banting
authors.forename: H J
authors.initials: HJ
authors.lastname: Smith
authors.forename: M
authors.initials: M
authors.lastname: James
authors.forename: G
authors.initials: G
authors.lastname: Jones
authors.forename: W
authors.initials: W
authors.lastname: Nazareth
authors.forename: P J
authors.initials: PJ
authors.lastname: Nicholls
authors.forename: M J
authors.initials: MJ
authors.lastname: Hewlins
authors.forename: M G
authors.initials: MG
authors.lastname: Rowlands
mesh_terms: D000735:Androstenedione / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D047072:Aromatase Inhibitors; D001665:Binding Sites; D002786:Cholesterol Side-Chain Cleavage Enzyme / Q000037:antagonists & inhibitors; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D013329:Structure-Activity Relationship
chemical_list: D047072:Aromatase Inhibitors; D000735:Androstenedione; D002786:Cholesterol Side-Chain Cleavage Enzyme