Expression of Ley antigen in human immunodeficiency virus-infected human T cell lines and in peripheral lymphocytes of patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC).
Ley determinant (Fuc alpha 1----2Gal beta 1----4[Fuc alpha 1----3]GlcNAc beta 1----R) defined by mAb BM-1 is highly expressed in human immunodeficiency virus (HIV)-infected T cell lines and in CD3+ peripheral mature T cells of patients with acquired immune deficiency syndrome (AIDS) or with AIDS-related complex (ARC). Ley expression increased greatly in the CD3+ population in the advanced stage of AIDS when the CD4+ population decreased greatly. Six other carbohydrate antigens tested by their respective mAbs were not detected in these same cells. None of the carbohydrate antigens tested by the seven mAbs used in this study were found in noninfected T cell lines and in normal peripheral blood lymphocytes.
Adachi
M
M
Japan Immunoresearch Laboratories, Takasaki.
Hayami
M
M
Kashiwagi
N
N
Mizuta
T
T
Ohta
Y
Y
Gill
M J
MJ
Matheson
D S
DS
Tamaoki
T
T
Shiozawa
C
C
Hakomori
S
S
D000386:AIDS-Related Complex / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D000937:Antigen-Antibody Reactions; D002460:Cell Line; D006028:Glycosphingolipids / Q000032:analysis*; D006678:HIV / Q000276:immunology*; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000276:immunology; D013601:T-Lymphocytes / Q000032:analysis / Q000276:immunology*
D000911:Antibodies, Monoclonal; D006028:Glycosphingolipids; D007983:Lewis Blood Group Antigens; C048890:Le(y)-active trifucosylnonaosylceramide