Blended effects of herbal components of tokishakuyakusan on rat corpus luteum function in vivo.
The effect of herbal components of Tokishakuyakusan on progestin levels in serum and ovarian tissue from rats treated with PMS and hCG was examined in vivo. Hoelen + peony root + Japanese angelica root increased progesterone/20 alpha-OHP ratio in serum, and hoelen or peony root also increased the ratio in ovarian tissue, while atractylodes lanceae rhizome or hoelen + atractylodes lanceae rhizome decreased the ratio in serum and ovarian tissue. These data suggested that hoelen or peony root has a luteotropic effect but that atractylodes lanceae rhizome develops luteolysis. Furthermore, the data indicated a blended effect of herbal components of Tokishakuyakusan on the corpus luteum.
Usuki
S
S
Department of Obstetrics and Gynecology, University of Tsukuba, Ibaraki, Japan.
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects* / Q000502:physiology; D004339:Drug Compounding; D004365:Drugs, Chinese Herbal; D005260:Female; D006027:Glycosides / Q000494:pharmacology*; D010946:Plants, Medicinal; D011374:Progesterone / Q000096:biosynthesis; D051381:Rats
D004365:Drugs, Chinese Herbal; D006027:Glycosides; C413220:toki-shakuyaku-san; D011374:Progesterone