title: A study of pentylenetetrazol kindling in rats and mice.
abstract: The effect of repeated injection of pentylenetetrazol on pentylenetetrazol seizure thresholds was determined in mice and rats. Once per week treatment of rats with pentylenetetrazol resulted in the development of a state of kindling. On the other hand, when pentylenetetrazol was administered twice per week, a phenomenon resembling tolerance was observed. In mice, it was not possible to demonstrate kindling under experimental conditions utilizing either one or two treatments with PTZ per week.
authors.affiliation: Department of Pharmacology and Toxicology, West Virginia University Health Sciences Center, Morgantown 26506.
authors.forename: C R
authors.initials: CR
authors.lastname: Craig
authors.forename: B K
authors.initials: BK
authors.lastname: Colasanti
mesh_terms: D000818:Animals; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D007696:Kindling, Neurologic; D051379:Mice; D010433:Pentylenetetrazole / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012934:Social Isolation; D013997:Time Factors
chemical_list: D010433:Pentylenetetrazole