title: Determination of amiodarone hydrochloride in pharmaceutical formulations by derivative UV spectrophotometry and high-performance liquid chromatography (HPLC).
abstract: Assay procedures based on derivative ultraviolet spectrophotometry and high-performance liquid chromatography (HPLC) have been developed for the specific determination of amiodarone hydrochloride in pharmaceutical dosage forms. The use of first- and second-order derivative spectrophotometry was found to have suppressed the background absorption from the excipients with comparable accuracy and precision to the reversed-phased HPLC reference method. A conventional UV absorption method (lambda = 242 nm) is subject to possible interference by formulation excipients.
authors.affiliation: Department of Pharmaceutical Sciences, University of Bologna, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Di Pietra
authors.forename: V
authors.initials: V
authors.lastname: Cavrini
authors.forename: R
authors.initials: R
authors.lastname: Gatti
authors.forename: M A
authors.initials: MA
authors.lastname: Raggi
mesh_terms: D000638:Amiodarone / Q000032:analysis*; D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
chemical_list: D002214:Capsules; D013607:Tablets; D000638:Amiodarone