Interleukin 1 modulates collagen accumulation by rat granulation tissue cells both in vivo and in vitro.
In in vivo studies 0.5 U human interleukin 1 (IL-1) was inoculated daily into a subcutaneously implanted viscose cellulose sponge. IL-1 significantly decreased the dry weight (7.8%) and the hydroxyproline content (24.2%) of granulomas. When the cultured rat granulation tissue cells were exposed to IL-1 (0.5-2.0 U/ml) their collagen production decreased to 80% of that in controls. No effect on cell proliferation was detected.
Laato
M
M
Department of Medical Chemistry, University of Turku, Finland.
Heino
J
J
D000818:Animals; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D006097:Granulation Tissue / Q000033:anatomy & histology / Q000378:metabolism*; D006909:Hydroxyproline / Q000378:metabolism; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains
D007375:Interleukin-1; D003094:Collagen; D006909:Hydroxyproline