On the mechanism of antiaggregatory effect of myricetin.
Myricetin at a dose of 3.6 micrograms/kg iv was found to inhibit the cat blood platelet aggregation in vivo. It disaggregated platelet thrombi in vitro at a concentration of 60 nM. This flavonoid bound to platelet membranes and prevented prostacyclin synthase against oxygen free radicals owing to its antioxidant properties. Myricetin inhibited soybean lipoxygenase when linoleic acid was used as a substrate.
Robak
J
J
Department of Pharmacology, N. Copernicus Academy of Medicine, Kraków, Poland.
Korbut
R
R
Shridi
F
F
Swies
J
J
Rzadkowska-Bodalska
H
H
D000818:Animals; D002415:Cats; D005419:Flavonoids / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D013997:Time Factors
D005419:Flavonoids; C040015:myricetin