title: [Acute myocarditis with localized left ventricular aneurysm: a report of three cases].
abstract: Ventricular aneurysms are rarely observed in viral myocarditis. Three cases whose left ventriculograms showed localized left ventricular aneurysms in the chronic phase of myocarditis are reported. The etiology in one case was herpes simplex virus (Case 1). Two cases (Case 2, 3) of myocarditis were admitted to our Coronary Care Unit in the acute phase, when diffuse hypokinesis of the left ventricle was demonstrated by two-dimensional (2-D) echocardiography. Hypokineses progressed to localized left ventricular aneurysm formation, demonstrated by cine angiography. In the acute phase, ST segment elevation was observed in these two cases, but it resolved. Abnormal Q waves also resolved in the chronic phase. Negative T waves were nearly normalized in one of them (Case 3). Abnormal Q waves with ST segment depression were observed in another case (Case 1). Thus, there were no characteristic or consistent findings suggesting a left ventricular aneurysm on electrocardiography. 2-D echocardiography and cine angiography proved useful for diagnosing this uncommon complication. Long-term follow-up of these cases will be important, because viral myocarditis can develop into dilated cardiomyopathy. The mechanism of left ventricular aneurysm following acute viral myocarditis included: (1) direct viral injury of the myocardium, (2) localized injury due to immunological mechanisms, and (3) coronary thrombosis due to increased platelet aggregation by viral infection.
authors.affiliation: First Department of Medicine, Kinki University School of Medicine, Osaka-sayama.
authors.forename: M
authors.initials: M
authors.lastname: Morishita
authors.forename: A
authors.initials: A
authors.lastname: Oda
authors.forename: A
authors.initials: A
authors.lastname: Okayama
authors.forename: I
authors.initials: I
authors.lastname: Ogawa
authors.forename: H
authors.initials: H
authors.lastname: Namikawa
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Takada
authors.forename: T
authors.initials: T
authors.lastname: Inoki
authors.forename: K
authors.initials: K
authors.lastname: Kanamasa
authors.forename: K
authors.initials: K
authors.lastname: Ishikawa
mesh_terms: D000208:Acute Disease; D000328:Adult; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006322:Heart Aneurysm / Q000175:diagnosis / Q000209:etiology*; D006352:Heart Ventricles; D006561:Herpes Simplex; D006801:Humans; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000150:complications*; D011877:Radionuclide Imaging