title: Pharmacological evaluation of prophylactic anti-asthma drugs by reference to the pathological sequelae of exposure to allergen or platelet activating factor.
abstract: Exposure of guinea-pigs to platelet activating factor (PAF) induces airway hyperreactivity and causes an influx of eosinophils into the airways. These effects are inhibited by the established prophylactic anti-asthma drugs; cromoglycate, aminophylline, glucocorticosteroids and ketotifen, whereas other drug categories, with the exception of PAF-receptor antagonists, are ineffective.
authors.affiliation: Sandoz AG, Preclinical Research, Basle, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Morley
authors.forename: S
authors.initials: S
authors.lastname: Sanjar
authors.forename: K
authors.initials: K
authors.lastname: Boubekeur
authors.forename: S
authors.initials: S
authors.lastname: Aoki
authors.forename: A
authors.initials: A
authors.lastname: Kristersson
mesh_terms: D000485:Allergens; D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000209:etiology; D004341:Drug Evaluation; D004802:Eosinophilia / Q000188:drug therapy / Q000209:etiology; D006168:Guinea Pigs; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors* / Q000502:physiology; D012137:Respiratory System / Q000187:drug effects
chemical_list: D000485:Allergens; D010972:Platelet Activating Factor