Effect of tranexamic acid on gastric bleeding in rats.
Bleeding from an induced gastric mucosal wound was monitored for 2 h in a rat model, in which normal hemostasis was disturbed mechanically by perfusing the lesion with saline. The hemorrhage was characterized by continuous bleeding and/or episodes of spontaneous rebleeding, as often seen in patients with gastric hemorrhage. The antifibrinolytic agent, tranexamic acid, significantly reduced total bleeding volume and number of rebleeding episodes, suggesting that plasmin-induced fibrinolysis might aggravate gastric mucosal hemorrhage.
Berstad
A
A
Division of Gastroenterology, University of Alabama, Birmingham.
Almodovar
K
K
Berstad
K
K
Anderson
W
W
Hirschowitz
B I
BI
D000818:Animals; D003509:Cyclohexanecarboxylic Acids / Q000008:administration & dosage*; D005342:Fibrinolysis / Q000187:drug effects; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D007262:Infusions, Intravenous; D051381:Rats; D011919:Rats, Inbred Strains; D014148:Tranexamic Acid / Q000008:administration & dosage*
D003509:Cyclohexanecarboxylic Acids; D014148:Tranexamic Acid