[Active antihelminitic alkaloids: active in vitro against Leishmanic Tropica the protozoa involved in leishmaniasis].
Leishmaniasis caused by protozoan Leishmania ssp., is an endemic parasitic disease in Central and South America. The chemotherapeutic agents against Leishmania ssp. (pentavalent antimony compounds, pentamidine and amphothericine B) are toxic and expensive products. Basing on the Bolivian folk medicine, we tried to find new active principles. Fourteen isoquinoline alkaloids, especially bisbenzylisoquinoline alkaloids extracted from Annonaceae, Berberidaceae, Hernandiaceae and Menispermaceae, demonstrate highly effective activity against this protozoan. Among them gyrocarpine, daphnandrine and obaberine seem to be of particular interest. The therapeutic effect was studied by biological assays on culture forms in vitro three strains of Leishmania, L. donovani, L. braziliensis (cutaneous and mucocutaneous leishmaniasis), L. mexicana amazonensis (cutaneous) and L. donovani (visceral leishmaniasis).
Fournet
A
A
Laboratoire de Pharmacognosie, ORSTOM-IBBA, La Paz, Bolivia.
Muñoz
V
V
Manjon
A M
AM
Angelo
A
A
Hocquemiller
R
R
Cortes
D
D
Cave
A
A
Bruneton
J
J
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents; D001838:Bolivia; D004353:Drug Evaluation, Preclinical; D007546:Isoquinolines / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D007892:Leishmania braziliensis / Q000187:drug effects; D007893:Leishmania donovani / Q000187:drug effects; D007894:Leishmania mexicana / Q000187:drug effects; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000494:pharmacology
D000470:Alkaloids; D000981:Antiprotozoal Agents; D007546:Isoquinolines; D010936:Plant Extracts
Activité antiparasitaire d'alcaloïdes bisbenzylisoquinoleiques. I: Activité in vitro sur des promastigotes de trois souches de Leishmania.