[Synthesis of 5-bromosalicyl-4'-chloroanilide-O-beta-D-xylopyranoside and other transport forms enzymatically activated by microbes].
The synthesis of 5-bromosalicyl-4'-chloroanilide-O-beta-D-xylopyranoside and other glycosides of 5-bromosalicyl-4'-chloroanilide, salicylanilide, 3,5-dichlorophenol and tetrachlorohydrochinone is described. Glycosidations follow the procedures described by Latham et al. Sabalitschka and Helferich et al. These glycosides represent relatively untoxic transport-forms of drugs, which are activated to the free drug by specific enzymes of the organisms to be destroyed. This new mechanisms can help to destroy fungi and parasites in dermatology, agriculture, horticulture and cultivation of decorative plants without side effects on the host.
Schwabe
K
K
Zentralinstitut für Krebsforschung, Akademie der Wissenschaften der DDR, Berlin-Buch.
Tschiersch
B
B
Wohlrab
W
W
Redslob
J
J
D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004337:Drug Carriers; D004789:Enzyme Activation; D006027:Glycosides / Q000138:chemical synthesis* / Q000494:pharmacology; D012459:Salicylates / Q000138:chemical synthesis* / Q000494:pharmacology
D000890:Anti-Infective Agents; D004337:Drug Carriers; D006027:Glycosides; D012459:Salicylates; C035836:ZIK 1392
Synthese des 5-Bromsalicyl-4'-chloranilid-O-beta-D-xylopyranosids und weiterer durch Mikroben enzymatisch aktivierbarer Wirkstoff-Transportformen.