title: Inhibition of complement activation by high-dose corticosteroids in total hip arthroplasty.
abstract: Anaphylatoxins are released during total hip arthroplasties (THA) when methylmethacrylate is used. These toxins may be responsible for hemodynamic and pulmonary instability during surgery. Recent studies have shown that the release of anaphylatoxins may be inhibited by high-dose corticosteroids (HDC). In a double-blind study 30 consecutive patients with osteoarthritis or failed hip fractures were randomized into two groups; 15 patients received HDC at the beginning of the operation and 15 patients, designated the control group, received infused saline. Anaphylatoxin formation, arterial oxygen tension, and blood pressure were determined preoperatively, during the operation, and one day postoperatively. The patients who received HDC had no significant alteration regarding the anaphylatoxins or arterial oxygen tension during surgery. However, in the control group elevated C3a levels and decreased PaO2 levels were found. Corticosteroids therefore inhibit complement activation and anaphylatoxin release in hip arthroplasty surgery.
authors.affiliation: Department of Orthopedic Surgery, Ludvika Hospital, Sweden.
authors.forename: W
authors.initials: W
authors.lastname: Gammer
authors.forename: A
authors.initials: A
authors.lastname: Bengtson
authors.forename: M
authors.initials: M
authors.lastname: Heideman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000706:Anaphylatoxins / Q000037:antagonists & inhibitors*; D003167:Complement Activation / Q000187:drug effects*; D003176:Complement C3 / Q000032:analysis; D015926:Complement C3a; D003182:Complement C5 / Q000032:analysis; D015936:Complement C5a; D004311:Double-Blind Method; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000601:surgery*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D010455:Peptides / Q000037:antagonists & inhibitors*; D011292:Premedication; D011897:Random Allocation
chemical_list: D000706:Anaphylatoxins; D003176:Complement C3; D003182:Complement C5; D010455:Peptides; D015926:Complement C3a; D015936:Complement C5a; D010100:Oxygen; D008775:Methylprednisolone