Effects of apomorphine in quantified electroencephalography in the frontal cortex: changes with dose and time.
The purpose of this study was to investigate the role of four doses of apomorphine (0.01, 0.05, 0.25, 1 mg/kg s.c.) on the cortical activity by a quantified electroencephalography (EEG) method recently developed in our laboratory. The EEG-effects of apomorphine were changed significantly according to the dose and the time. When initial effects were considered an opposition in the apomorphine-induced variations between low (0.01 mg/kg) and higher doses were observed. In the time course with 0.01, 0.25 and 1 mg/kg SC, EEG variations changed the direction in 6-17 Hz and diminished in the other spectral components. Qualitatively, this tardive change with 0.01 mg/kg may show a feed-back response of the dopaminergic system to the initial low dose-induced depressant effects of apomorphine. On the other hand higher doses-induced tardive EEG pattern may show a possible changed balance in the stimulated D1 and D2 receptors.
Shvaloff
A
A
Laboratoire de Biologie du Vieillissement, Hopital Charles Foix, Ivry/Seine, France.
Tesolin
B
B
Sebban
C
C
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001058:Apomorphine