title: Comparative potency of carbachol, sham feeding, fundic distension and 16,16-dimethyl prostaglandin E2 as stimulants of human gastric bicarbonate secretion.
abstract: Six healthy subjects in random order underwent gastric bicarbonate secretion investigations, including stimulation with increasing doses of the cholinergic agonist carbachol, sham feeding, fundic distension and gastric instillation of 16,16-dimethyl prostaglandin E2. Bicarbonate secretion was measured by a computer-based system which continuously recorded pH and PCO2 of the effluent in a high-volume gastric perfusion system. The peak 30 min gastric bicarbonate output in response to carbachol, 150 mg subcutaneously, was 114% (P less than 0.05). Vagal stimulation by sham feeding resulted in a corresponding increase of 112% (P less than 0.05), while fundic distension to a volume of 600 ml gave an increase of 114% (P less than 0.05). In comparison, the response to 80 micrograms 16,16-dimethyl prostaglandin E2 was much greater, the peak bicarbonate output being increased by 245% (P less than 0.05). Both sham feeding and fundic distension appear to be either submaximal stimuli of gastric bicarbonate secretion in man or may possess both stimulatory and inhibitory actions.
authors.affiliation: Department of Surgery, Sahlgren's Hospital, Gothenburg University, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Forssell
authors.forename: T
authors.initials: T
authors.lastname: Lind
authors.forename: L
authors.initials: L
authors.lastname: Olbe
mesh_terms: D015064:16,16-Dimethylprostaglandin E2 / Q000494:pharmacology*; D000328:Adult; D001639:Bicarbonates / Q000378:metabolism*; D002217:Carbachol / Q000494:pharmacology*; D005260:Female; D005502:Food; D005748:Gastric Fundus / Q000502:physiology; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008297:Male; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*
chemical_list: D001639:Bicarbonates; D011459:Prostaglandins E, Synthetic; D002217:Carbachol; D015064:16,16-Dimethylprostaglandin E2