Differential effect of d-fenfluramine and metergoline on food intake in human subjects.
This study investigated the effect of the 5-HT receptor blocker metergoline (MTG) on d-fenfluramine (d-FF)-induced reduction of food intake in 13 normal male human volunteer subjects. Food was freely available for 2h, 4h after drug administration, from a four-channel automated food dispenser. d-FF (30 mg) reduced total food intake and exerted a marked effect on non-sweet food which was attenuated by the addition of MTG (4 mg). d-FF had less effect on sweet-tasting food while intake of sweet food was significantly increased by MTG. There was a significant interaction between d-FF and MTG on sweet-tasting foods. No effect on MTG was observed on d-FF-induced changes in ratings of hunger.
Goodall
E
E
Academic Unit of Human Psychopharmacology, Medical College of St Bartholomew's Hospital, London.
Silverstone
T
T
D000293:Adolescent; D000328:Adult; D000855:Anorexia / Q000139:chemically induced; D001066:Appetite / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D004873:Ergolines / Q000494:pharmacology*; D005277:Fenfluramine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008711:Metergoline / Q000494:pharmacology*; D012528:Satiety Response / Q000187:drug effects; D012702:Serotonin Antagonists; D013997:Time Factors
D004873:Ergolines; D012702:Serotonin Antagonists; D008711:Metergoline; D005277:Fenfluramine