title: Optic neuropathy as an initial manifestation of Sjögren's syndrome.
abstract: Although optic neuropathy is a known complication of systemic lupus erythematosus, its association with other connective tissue diseases is less well documented. We describe 3 previously asymptomatic women presenting with optic neuropathy in whom changes highly suggestive of primary Sjögren's syndrome (SS) were found by minor salivary gland biopsy 1-6 years after initial presentation. Typical symptoms of SS were absent initially and developed slowly, while serologic abnormalities were consistently present. Optic neuropathy may be a presenting neurologic feature of SS and may antedate typical signs and symptoms of SS. Primary SS should be considered in the differential diagnosis of optic neuropathy.
authors.affiliation: Department of Medicine, Bowman Gray School of Medicine, Winston-Salem, NC 27103.
authors.forename: C M
authors.initials: CM
authors.lastname: Wise
authors.forename: C A
authors.initials: CA
authors.lastname: Agudelo
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009103:Multiple Sclerosis / Q000175:diagnosis; D009901:Optic Nerve Diseases / Q000150:complications / Q000175:diagnosis*; D012470:Salivary Glands, Minor / Q000473:pathology; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D014786:Vision Disorders / Q000209:etiology
chemical_list: D000974:Antibodies, Antinuclear