Recognition and transport of adenine derivatives with synthetic receptors.
Several new synthetic agents show high affinity for binding adenine derivatives. The structures feature complementary hydrogen bonds that cause the molecular chelation of the purine nucleus. The high lipophilicity of the new agents permits the transport of adenosine and deoxyadenosine across organic liquid membranes. The use of synthetic receptors for small biological targets may have application in drug delivery.
Benzing
T
T
Department of Chemistry, University of Pittsburgh, PA 15260.
Tjivikua
T
T
Wolfe
J
J
Rebek
J
J
D000225:Adenine / Q000031:analogs & derivatives / Q000378:metabolism*; D001692:Biological Transport; D002725:Chloroform; D003839:Deoxyadenosines / Q000378:metabolism; D004337:Drug Carriers; D006860:Hydrogen Bonding; D007700:Kinetics; D008567:Membranes, Artificial; D015394:Molecular Structure
D003839:Deoxyadenosines; D004337:Drug Carriers; D008567:Membranes, Artificial; D002725:Chloroform; D000225:Adenine