title: [Disoprivan (Propofol) sedation during regional anesthesia. A pilot study].
abstract: In a preliminary pilot study, the effect of disoprivan for sedation during regional anesthesia was investigated. In 15 patients (ASA I or II), lumbar epidural anesthesia with bupivacaine 0.75% was performed at L 3/4. For premedication morphine or pethidine combined with scopolamine was given. After injection of the local anesthetic, a 30-min period was allowed for establishing the physiological side effects of epidural blockade, to present any further changes in circulatory and/or cardiac function. Disoprivan (1 mg/kg body weight) was injected i.v. followed by continuous disoprivan infusion. Three groups of 5 patients each were given 1, 1.5, or 2 mg/kg per hour disoprivan. Changes in heart rate, blood pressure, and respiratory rate were studied. Recovery time and personal assessment of sleep were registered. Side-effects of clinical relevance from the cardiovascular and pulmonary systems were also registered. A dose-dependent upper airway obstruction that could easily be managed by an oral or nasal airway was seen in 9 of 15 patients. Eight patients had postoperative nausea or vomiting; 9 complained of pain during the bolus injection that they could not remember postoperatively. All patients described their sleep as pleasant. Recovery time from sleep was between 1 and 12 min. All changes from normal values increased in percentage with increasing disoprivan dosage. Disoprivan (1 or 1.5 mg/kg per hour) seems to be excellent for sedation during regional anesthesia and is perhaps even superior to other available drugs.
authors.affiliation: Institut für Anaesthesiologie, Klinikum Minden, Minden/Westfalen.
authors.forename: K
authors.initials: K
authors.lastname: Döbler
authors.forename: E
authors.initials: E
authors.lastname: Dombrowski
authors.forename: H
authors.initials: H
authors.lastname: Nolte
mesh_terms: D000328:Adult; D000368:Aged; D000767:Anesthesia, Epidural; D001794:Blood Pressure / Q000187:drug effects; D002045:Bupivacaine; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000494:pharmacology; D010865:Pilot Projects; D011183:Postoperative Complications / Q000453:epidemiology; D011229:Preanesthetic Medication; D015742:Propofol; D011446:Prospective Studies; D012119:Respiration / Q000187:drug effects
chemical_list: D006993:Hypnotics and Sedatives; D010636:Phenols; D002045:Bupivacaine; D015742:Propofol
vernacular_title: Disoprivan (Propofol) zur Sedierung während der Regionalanaesthesie. Eine Pilotstudie.