title: Isomer-specific determination of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds in human fat and food.
abstract: An analytical procedure for the isomer-specific quantification of polychlorinated dibenzo-p-dioxins and dibenzofurans in samples of human and animal origin is described. It consists of a large-scale clean-up including various kinds of column chromatography and high-resolution gas chromatographic/mass spectrometric quantification referring to internal 13C-labelled standards. By additional application of gel-permeation chromatography and the use of a retention gap, detection limits in the low ppq range (10(-15) were achieved.
authors.affiliation: Federal Health Office, Max von Pettenkofer Institute, Berlin, FRG.
authors.forename: H
authors.initials: H
authors.lastname: Beck
authors.forename: K
authors.initials: K
authors.lastname: Eckart
authors.forename: W
authors.initials: W
authors.lastname: Mathar
authors.forename: C S
authors.initials: CS
authors.lastname: Rühl
authors.forename: R
authors.initials: R
authors.lastname: Wittkowski
mesh_terms: D000818:Animals; D001822:Body Burden; D004041:Dietary Fats / Q000032:analysis; D004147:Dioxins / Q000032:analysis*; D005223:Fats / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007536:Isomerism; D008895:Milk, Human / Q000032:analysis; D000072317:Polychlorinated Dibenzodioxins / Q000032:analysis*; D013552:Swine
chemical_list: D004041:Dietary Fats; D004147:Dioxins; D005223:Fats; D000072317:Polychlorinated Dibenzodioxins