[Lipid and protein composition of membranes and carbohydrate metabolism in rats subjected to bilateral adrenalectomy; correction of disorders by vitamins K and E].
Experiments in rats have confirmed that fractional composition of membrane (mitochondria, erythrocytes) phospholipids changes under adrenalectomy conditions. These changes are accompanied by disturbances in quantitative composition and correlation of basic phospholipid fractions (phosphatidyl ethanolamine, phosphatidyl choline, cholesterol and its ether). While investigating the content of integral proteins and lipoproteins under adrenalectomy conditions changes in absolute composition and correlation of fractions are observed. Additional injection of vitamins K and E to adrenalectomized animals prevented these disturbances. Changes of main biomembrane structural components (mitochondria, erythrocytes) were accompanied by changes in the direction of metabolism.
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D000315:Adrenalectomy; D000818:Animals; D050260:Carbohydrate Metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism; D008297:Male; D008563:Membrane Lipids / Q000097:blood / Q000378:metabolism*; D008565:Membrane Proteins / Q000097:blood / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D010743:Phospholipids / Q000097:blood / Q000378:metabolism; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology*; D014812:Vitamin K / Q000494:pharmacology*
D008074:Lipoproteins; D008563:Membrane Lipids; D008565:Membrane Proteins; D010743:Phospholipids; D014812:Vitamin K; D014810:Vitamin E
Lipidnyĭ i belkovyĭ sostav membran i uglevodnyĭ obmen u krys s dvustoronneĭ adrenaléktomieĭ; korrektsiia narusheniĭ vitaminami K i E.