[Effect of glycopyrrolate and atropine on the behavior of heart rate and pH value of gastric juice during microlaryngoscopies].
In a prospective study a total of 51 patients were given either a premedication with atropine (10 micrograms/kg) (n = 17), with glyopyrrolate (5 micrograms/kg) (n = 15) or no anticholinergic premedication (n = 19). In the group of patients premedicated with glycopyrrolate the pH levels of the gastric juice were more often above 2.50 than in the group without anticholinergic premedication (p less than 0.05). During the microlaryngoscopic interventions there was a trend to fewer A-node rhythms or bradycardias in the group premedicated with glycopyrrolate than in the other groups. Reduction of salivary gland secretion by anticholinergics made intervention easier. Glycopyrrolate has advantages over atropine as far as the induction of anaesthesia for microlaryngoscopic interventions is concerned.
Lischke
V
V
Zentrum der Anaesthesiologie und Wiederbelebung der Johann-Wolfgang-Goethe-Universität, Frankfurt am Main.
Behne
M
M
Mickel
A
A
D000368:Aged; D000369:Aged, 80 and over; D000768:Anesthesia, General; D001285:Atropine / Q000008:administration & dosage*; D005745:Gastric Acidity Determination; D006024:Glycopyrrolate / Q000008:administration & dosage*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007828:Laryngoscopy; D011229:Preanesthetic Medication; D011446:Prospective Studies; D011759:Pyrrolidines / Q000008:administration & dosage*; D012472:Salivation / Q000187:drug effects
D011759:Pyrrolidines; D001285:Atropine; D006024:Glycopyrrolate
Untersuchungen zum Einfluss von Glycopyrrolat und Atropin auf das Verhalten der Herzfrequenz und den pH-Wert des Magensaftes während Mikrolaryngoskopien.