title: Human gastric lipase: variations induced by gastrointestinal hormones and by pathology.
abstract: Secretin and cholecystokinin-pancreozymin had no effect on the secretion of human gastric lipase, in contrast to pentagastrin, which increased the gastric lipase output but not the enzyme concentration in gastric juice. The secretion of gastric lipase was not significantly different in patients with duodenal ulcer or chronic pancreatitis and in controls. In contrast, basal gastric lipase concentration was significantly lower in children with cystic fibrosis than in normal children. This shows that neither in adults nor in children is there a compensation for a decreased lipase secretion by an increased gastric lipase secretion.
authors.affiliation: Center for Biochemistry and Molecular Biology of the CNRS, Marseilles; France.
authors.forename: H
authors.initials: H
authors.lastname: Moreau
authors.forename: J F
authors.initials: JF
authors.lastname: Sauniere
authors.forename: Y
authors.initials: Y
authors.lastname: Gargouri
authors.forename: G
authors.initials: G
authors.lastname: Pieroni
authors.forename: R
authors.initials: R
authors.lastname: Verger
authors.forename: H
authors.initials: H
authors.lastname: Sarles
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003550:Cystic Fibrosis / Q000503:physiopathology*; D010188:Exocrine Pancreatic Insufficiency / Q000503:physiopathology*; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology*; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D006801:Humans; D008049:Lipase / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D005768:Gastrointestinal Hormones; D008049:Lipase