Molecular interaction of non-steroidal compounds with uterine progesterone receptor (Part II).
Some possible non-steroidal antiprogestins were evaluated for their receptor binding activity by competitive protein binding assay in rabbit as well as human uterine cytosol in vitro. Of the 42 compounds belonging to 5 different series tested, dimethyl ester of monobenzylidene succinic acid, 4-ethoxycarbonyl-3-(m-methoxybenzyl)-5-(m-anisyl)-gamma-butyrolact one and 2-(3-benzyl-oxybenzyl)-3-(3-acetoxybenzyl)butane-1,4-diol exhibit around 20% inhibition of 3H-progesterone binding to uterine cytosol in both species.
Agnihotri
A
A
Division of Endocrinology, Central Drug Research Institute, Lucknow, India.
Neelima
Seth
M
M
Bhaduri
A P
AP
Srivastava
A K
AK
Kamboj
V P
VP
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D011374:Progesterone / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011817:Rabbits; D011980:Receptors, Progesterone / Q000187:drug effects / Q000378:metabolism*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D011980:Receptors, Progesterone; D011374:Progesterone