CSF-endorphines in acute and chronic brain lesions.
In order to answer the question of an opioid influence on consciousness, a radio-immuno-assay (n = 852) of beta-endorphin and beta-LPH (beta-lipotropic hormone) in both ventricular CSF and blood plasma was carried out in 101 neurosurgical patients. The following results were obtained: I) beta-END and beta-LPH levels were found to be lower in the CSF than in blood plasma. II) beta-END and beta-LPH in the CSF was the same in both sexes. III) beta-END levels in the CSF decreased with age. IV) beta-END and beta-LPH levels showed a diurnal rhythm with a maximum in the late a. m. hours. V) beta-END levels in the ventricular CSF tend to decrease parallel to a drop in conciousness as well as with longlasting comatous states. VI) beta-END in ventricular CSF becomes higher with increasing systolic arterial blood pressure. VII) beta-END and beta-LPH levels in ventricular CSF are not correlated with the type of the disease, CSF pressure, body temperature or respiratory changes.
Hamel
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Department of Neurosurgery Klinikum Ingolstadt, West Germany.
D000328:Adult; D001927:Brain Diseases / Q000134:cerebrospinal fluid* / Q000150:complications; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid* / Q000150:complications; D003128:Coma / Q000134:cerebrospinal fluid* / Q000209:etiology; D004723:Endorphins / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D004723:Endorphins