[Effect of sulfalene and furosemide on benzylpenicillin kinetics in rats with aseptic inflammation].
The effect of sulfalen and furosemide on benzylpenicillin kinetics in blood serum, intact tissues and aseptic inflammation foci was studied on rats. It was shown that under the action of sulfalen and furosemide protein binding of benzylpenicillin lowered by 30 per cent. The changes in the antibiotic kinetics after combined use with sulfalen and furosemide were of the same type: markedly increased concentrations in blood serum and tissues and retarded elimination.
Agapitova
I V
IV
Iakovlev
V P
VP
D000818:Animals; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000378:metabolism; D004357:Drug Synergism; D005665:Furosemide / Q000008:administration & dosage / Q000494:pharmacology*; D010400:Penicillin G / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D013415:Sulfalene / Q000008:administration & dosage / Q000494:pharmacology*; D013424:Sulfanilamides / Q000494:pharmacology*
D013424:Sulfanilamides; D005665:Furosemide; D010400:Penicillin G; D013415:Sulfalene
Vliianie sul'falena i furosemida na kinetiku benzilpenitsillina u krys s asepticheskim vospaleniem.