Polyclonal B-cell stimulation by L3T4+ T cells in experimental leishmaniasis.
The well-established polyclonal B-cell stimulation in the lymphoid organs in mice infected with Leishmania major is thought to be dependent on T cells. Here we present clear experimental evidence that this is indeed the case by showing that BALB/c-derived, L3T4-positive L. major-specific T cells induce syngeneic B cells to polyclonal proliferation and immunoglobulin production.
Lohoff
M
M
Institut für Klinische Mikrobiologie, Universität Erlangen-Nürnberg, Federal Republic of Germany.
Matzner
C
C
Röllinghoff
M
M
D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis; D000921:Antibody-Producing Cells / Q000166:cytology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology*; D002999:Clone Cells / Q000276:immunology; D006183:H-2 Antigens / Q000276:immunology; D007895:Leishmania tropica; D007896:Leishmaniasis / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D000913:Antibodies, Protozoan; D000945:Antigens, Differentiation, T-Lymphocyte; D006183:H-2 Antigens