K transfer in ureter ligated dogs loaded with KCl.
In control ureter ligated dogs infused with 2 mEq KCl/kg.h until prelethal electrocardiographic changes of hyperkalemic cardiotoxicity appear, a kaluresis independent K homeostatic mechanism delays the development of hyperkalemia by transferring some 55% of administered K to intracellular fluid. In preparations with cervical trunk vagotomy the proportion increases to about 70%; but not if the adrenals are simultaneously removed or denervated. A dosage of atropine that crosses the blood-brain barrier is an exact substitute for cervical vagotomy. Our findings suggest that ureter ligated K loaded dogs, ureteral and/or renal afferent vagal fibres to the brain release a "muscarinic" neurotransmitter(s) that modulated neural traffic in rami of splanchnic nerves to the adrenal medulla.
Hiatt
N
N
Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Chapman
L W
LW
Mack
H
H
Hiatt
J
J
D000311:Adrenal Glands / Q000294:innervation; D000315:Adrenalectomy; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D003714:Denervation; D004285:Dogs; D006706:Homeostasis; D011188:Potassium / Q000378:metabolism*; D011189:Potassium Chloride / Q000378:metabolism; D012016:Reference Values; D014513:Ureter / Q000502:physiology*
D011189:Potassium Chloride; D001285:Atropine; D011188:Potassium