title: [Modifications in the urinary excretion of gamma-carboxyglutamic acid induced by vitamin K].
abstract: To evaluate urinary GLA excretion, a marker of vitamin K metabolism, the effect of an oral calcium load was studied in 8 volunteers under three conditions: (1) after 1.5 g elementary calcium (calcium carbonate), (2) after 1.5 g calcium (Ossopan, a preparation containing 1 mg osteocalcin per g) and (3) after 1.5 g calcium but with pretreatment of 10 mg vitamin K1 orally for 3 days. No differences in blood calcium, osteocalcin concentration of calciuria were observed. However, GLA excretion was significantly higher with Ossopan or after pretreatment with vitamin K1.
authors.affiliation: Service de médecine, Hôpital de la Providence, Neuchâtel.
authors.forename: D
authors.initials: D
authors.lastname: Werlen
authors.forename: D
authors.initials: D
authors.lastname: Robert
authors.forename: M
authors.initials: M
authors.lastname: Leclerq
authors.forename: G
authors.initials: G
authors.lastname: Guelpa
authors.forename: C E
authors.initials: CE
authors.lastname: Pfister
mesh_terms: D015055:1-Carboxyglutamic Acid / Q000652:urine*; D000328:Adult; D002118:Calcium / Q000494:pharmacology*; D002119:Calcium Carbonate / Q000494:pharmacology; D002135:Calcium-Binding Proteins / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D015675:Osteocalcin; D014812:Vitamin K / Q000494:pharmacology*
chemical_list: D002135:Calcium-Binding Proteins; D015675:Osteocalcin; D014812:Vitamin K; D015055:1-Carboxyglutamic Acid; D002119:Calcium Carbonate; D002118:Calcium
vernacular_title: Modifications de l'excrétion urinaire de GLA (acide gamma-carboxyglutamique) induite par la vitamine K.