Serum levels of RHP and of unbound C1q in rheumatoid arthritis and systemic lupus erythematosus.
RHP is a recently described serum protein which inhibits a number of physiologic functions of C1q unbound to C1r2 x C1s2. In this report we show that sera from patients with rheumatoid arthritis contained elevated levels of RHP and of unbound C1q. Sera from patients with systemic lupus erythematosus contained normal levels of RHP and were characterized by deficits of C1q required to form C1 from existing levels of C1r and C1s.
Rosano
C L
CL
Research Service, Veterans Administration Medical Center, Albany, New York.
Parhami
N
N
Hechemy
K E
KE
Hurwitz
C
C
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis*; D003166:Complement Activating Enzymes / Q000032:analysis*; D003172:Complement C1 / Q000032:analysis*; D003174:Complement C1 Inactivator Proteins / Q000032:analysis*; D015922:Complement C1q; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D008297:Male; D008875:Middle Aged
D001798:Blood Proteins; D003172:Complement C1; D003174:Complement C1 Inactivator Proteins; D015922:Complement C1q; D003166:Complement Activating Enzymes