Cardiac arrest--a manifestation of 5-fluorouracil cardiotoxicity.
We report a case of cardiac arrest occurring during an infusion of 5-fluorouracil where electrocardiograms suggested coronary artery spasm as the underlying event. Treatment with vasodilators and diltiazem, proved effective. This clinical presentation of 5-fluorouracil cardiotoxicity has not previously been described.
Millward
M J
MJ
Department of Medical Oncology, Sir Charles Gairdner Hospital, Nedlands, WA.
Ganju
V
V
Buck
M
M
D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D004562:Electrocardiography; D005472:Fluorouracil / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects*; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy
D005472:Fluorouracil