The biological activity and immunotherapeutic properties of AS-101, a synthetic organotellurium compound.
AS-101 (ammonium trichloro[dioxoethylene-O,O'-]tellurate) is a newly developed synthetic compound with immunomodulating properties and minimal toxicity. We evaluated the effects of AS-101 on various parameters of the activation and function of immunocompetent cells. AS-101 induced IL-2 receptor expression, IL-2 production and proliferation by human and mouse lymphocytes in vitro and enhanced the production colony-stimulating factor (CSF) by mouse spleen cells. In vivo treatment of Balb/c mice with AS-101 caused a significantly increased production of IL-2 and CSF in vitro in the presence of mitogen. When administered systemically to mice, AS-101 mediated antitumor effects in vivo. These results suggest that AS-101 is an active biological response modifier, which might have potential use in the treatment of conditions such as malignancy, AIDS and some types of immune deficiency.
Sredni
B
B
Department of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Caspi
R R
RR
Lustig
S
S
Klein
A
A
Kalechman
Y
Y
Danziger
Y
Y
Ben Ya'akov
M
M
Tamari
T
T
Shalit
F
F
Albeck
M
M
D000276:Adjuvants, Immunologic; D000818:Animals; D003115:Colony-Stimulating Factors / Q000096:biosynthesis; D005030:Ethylenes / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D006801:Humans; D007167:Immunotherapy; D007376:Interleukin-2 / Q000096:biosynthesis; D007928:Lethal Dose 50; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000628:therapy; D051381:Rats; D015375:Receptors, Interleukin-2 / Q000187:drug effects
D000276:Adjuvants, Immunologic; D003115:Colony-Stimulating Factors; D005030:Ethylenes; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; C054105:ammonium trichloro(dioxoethylene-O,O'-)tellurate