title: Aortic valve replacement and coronary bypass grafting for patients with aortic stenosis and coronary artery disease: early and late results.
abstract: From 1967 to 1981, 294 patients (group A) with aortic stenosis and coronary atherosclerosis underwent aortic valve replacement (AVR) combined with bypass grafting; there were 13 (4.4%) in-hospital deaths. Follow-up of the in-hospital survivors documented late survival of 89%, 79%, and 52% at 2, 5, and 10 postoperative years, respectively. Univariate and multivariate testing identified age greater than or equal to 70 years (P = 0.02) and Class IV symptoms (P = 0.002) as factors decreasing late survival. Patients with bioprostheses who did not take warfarin had the best late survival (P = 0.03) and event-free survival (P = 0.05) and patients with mechanical prostheses who did not take warfarin had the worst (P less than 0.0001) (P = 0.001). From 1981 to 1986, 375 further patients (group B) with aortic stenosis and coronary artery disease underwent AVR and bypass grafting with 20 (5.3%) in-hospital deaths. Group B contained more patients greater than or equal to 70 years (35% vs. 16%) than did group A. Logistic regression analysis identified patients with moderate or severe impairment of left ventricular function and women as sub-groups with increased in-hospital mortality in group B. Patients with aortic stenosis and coronary artery disease can undergo AVR and bypass grafting with a risk slightly increased over that for isolated AVR. Bioprostheses enhance late survival and event-free survival.
authors.affiliation: Cleveland Clinic Foundation, OH 44106.
authors.forename: B W
authors.initials: BW
authors.lastname: Lytle
authors.forename: D M
authors.initials: DM
authors.lastname: Cosgrove
authors.forename: M
authors.initials: M
authors.lastname: Goormastic
authors.forename: F D
authors.initials: FD
authors.lastname: Loop
mesh_terms: D000328:Adult; D000368:Aged; D001024:Aortic Valve Stenosis / Q000601:surgery*; D001026:Coronary Artery Bypass / Q000401:mortality*; D003327:Coronary Disease / Q000601:surgery*; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications; D012044:Regression Analysis; D012737:Sex Factors