title: In vivo treatment with IL-1 reduces the severity and duration of antigen-induced arthritis in rats.
abstract: IL-1 has been implicated in the pathogenesis of arthritis. Although IL-1 injected in vivo into normal joints results in a transient inflammatory reaction, we have shown that three weekly repetitive injections of IL-1 do not produce a progressive inflammatory condition suggestive of chronic arthritis. In fact, priming normal joints with three weekly IL-1 intraarticular injections results in a significant reduction in joint swelling and diminished histopathologic alterations/lesions caused by subsequent methylated BSA-induced arthritis. Similarly, post treatment with IL-1 intraarticular injection after arthritis induction reduced arthritic swelling and joint injury if IL-1 was given during the developing stage of arthritis. Our results suggest that IL-1 might limit arthritic inflammation and progressive cartilage destruction through an, as yet, undetermined mechanism(s). Further in vivo investigations are required to determine the therapeutic utility of IL-1 in reducing early arthritic inflammation.
authors.affiliation: Department of Cellular Immunology, Immunex Corporation, Seattle, WA 98101.
authors.forename: C
authors.initials: C
authors.lastname: Jacobs
authors.forename: D
authors.initials: D
authors.lastname: Young
authors.forename: S
authors.initials: S
authors.lastname: Tyler
authors.forename: G
authors.initials: G
authors.lastname: Callis
authors.forename: S
authors.initials: S
authors.lastname: Gillis
authors.forename: P J
authors.initials: PJ
authors.lastname: Conlon
mesh_terms: D000818:Animals; D000941:Antigens; D001168:Arthritis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D004334:Drug Administration Schedule; D005260:Female; D007270:Injections, Intra-Articular; D007375:Interleukin-1 / Q000008:administration & dosage* / Q000627:therapeutic use; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology; D011292:Premedication; D011859:Radiography; D051381:Rats; D011917:Rats, Inbred Lew; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D012710:Serum Albumin, Bovine; D013997:Time Factors
chemical_list: D000941:Antigens; D007375:Interleukin-1; D011994:Recombinant Proteins; C029180:methylated bovine serum albumin; D012710:Serum Albumin, Bovine