title: T cell receptor alpha mRNA transcription in T-lymphoblastic transformation of chronic myelocytic leukemia.
abstract: Analysis at the DNA and RNA level revealed a mature genetic marker profile in a case of T type blast crisis of chronic myelocytic leukemia. T cell receptor beta chain gene rearrangement as well as T cell receptor alpha mRNA transcription was demonstrated in blasts of the malignant clone. Corresponding findings were obtained from immunological phenotyping. Blasts were found to be CD7+, CD1+, CD3+, CD4+, CD8+, and TdT- and classified as common/mature thymocytes. The presence of the breakpoint cluster region gene on chromosome 22 excluded the possibility of a second neoplastic process.
authors.affiliation: Department of Medicine, University of Vienna, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Valent
authors.forename: C R
authors.initials: CR
authors.lastname: Bartram
authors.forename: T
authors.initials: T
authors.lastname: Radaszkiewicz
authors.forename: W
authors.initials: W
authors.lastname: Hinterberger
authors.forename: K
authors.initials: K
authors.lastname: Lechner
authors.forename: P
authors.initials: P
authors.lastname: Bettelheim
mesh_terms: D000328:Adult; D000954:Antigens, Surface / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000032:analysis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D008213:Lymphocyte Activation; D008297:Male; D010641:Phenotype; D012333:RNA, Messenger / Q000032:analysis; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology*; D014158:Transcription, Genetic
chemical_list: D000954:Antigens, Surface; D012333:RNA, Messenger; D011948:Receptors, Antigen, T-Cell