Changes in sulfhydryl compounds in plasma, liver and brain after acute and chronic acetaldehyde administration in rats.
The content of sulfhydryl compounds in proteins and non-proteins of plasma, liver and brain after acute and chronic administration of acetaldehyde (ACH) was investigated in rats. After ACH 1.5% w/v ingestion for 1 and 4 weeks (0.3 ml/kg) daily, proteins and non-proteins in plasma and liver were decreased significantly. After acute ACH administration SH-groups in brain proteins were not significantly decreased, but in the brain non-proteins these groups were increased significantly.
Farbiszewski
R
R
Department of Inorganic and Analytical Chemistry, Medical Academy, Białystok, Poland.
Chwiećko
M
M
Hołownia
A
A
Brzozowski
M
M
D000079:Acetaldehyde / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000097:blood*
D013438:Sulfhydryl Compounds; D000079:Acetaldehyde