[Ultrastructural restructurings in the rat cerebral cortex after ascorbic acid administration into the ventricular cerebrospinal fluid].
A short increase of the ascorbic acid concentration in the rat cerebral cortex after intraventricular bilateral injection of 20 mcl of 0.1% or 1% solution of ascorbic acid, as well as intracisternal injection of 20 mcl of 0.5% solution results in a prolonged (no less than 21 days) ultrastructural reorganization in the nucleus and cytoplasm of the cortical neurons: amount of lysosomes, polysomes, vesicles of the Golgi complex, subsurface cisterns increases; this demonstrates an increasing RNA and protein synthesis, catabolic processes and neuronal-glial interaction. Changes of ultrastructure of the synaptic terminals--decaying mitochondria in them, formation of myelin-like bodies and after interstitial injection, in addition, protrusions into the adjusting dendrite--demonstrate that synapses are also one of the points, where excess of ascorbic acid affects the CNS. In a long time 3 and 6 months after injection, the changes mentioned are not observed, but in the glial processes there are vacuoles, containing degenerating elements.
Grigor'ev
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IP
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000648:ultrastructure; D002555:Cerebrospinal Fluid / Q000187:drug effects*; D002946:Cisterna Magna; D007267:Injections; D007276:Injections, Intraventricular; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012996:Solutions; D013997:Time Factors
D012996:Solutions; D001205:Ascorbic Acid
Ul'trastrukturnye perestroĭki v kore bol'shogo mozga krys posle vvedeniia askorbinovoĭ kisloty v likvor zheludochkov.