[Establishment of a new hereditary-cataract mouse (CSM) strain derived from SENCAR mouse].
A mouse representing a new hereditary cataract strain was found in a mouse colony and a new line was established strain CSM. These mice were investigated genetically, histologically and biochemically. The results suggested that this cataract was apparently inherited through two recessive autosomal genes. Histologically the denucleation process of lens fibers was abnormal and small vacuoles appeared in the equatorial region of the lens cortex at 12 days. Biochemically, insoluble protein and sodium increased in the lens with age.
Sato
T
T
Drug Development Laboratories, CHUGAI Pharmaceutical Co., Ltd., Tokyo, Japan.
Miyai
T
T
Akaike
I
I
Togashi
M
M
Kojima
M
M
Okamoto
M
M
D000818:Animals; D002386:Cataract / Q000235:genetics* / Q000473:pathology; D004195:Disease Models, Animal; D005808:Genes, Recessive; D007904:Lens Cortex, Crystalline / Q000473:pathology*; D007908:Lens, Crystalline / Q000473:pathology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*