title: Induction and maintenance of propofol anaesthesia. A manual infusion scheme.
abstract: A simple, manually controlled infusion scheme for continuous administration of propofol was derived by simulation of a computer algorithm designed to achieve a predetermined blood concentration of propofol within 2 minutes and to maintain a constant blood level for the duration of surgery. The manual infusion scheme for a target blood propofol concentration of 3 micrograms/ml, consisted of a loading dose of 1 mg/kg followed immediately by an infusion of 10 mg/kg/hour for 10 minutes, 8 mg/kg/hour for the next 10 minutes and 6 mg/kg/hour thereafter. An overall mean blood propofol concentration of 3.67 micrograms/ml was achieved within 2 minutes and maintained stable for the subsequent 80-90 minutes of surgery. The decrease of systolic and diastolic arterial pressures at induction was much less than that previously described after larger induction doses of propofol and there was a negligible haemodynamic response to laryngoscopy and intubation or to the subsequent surgery. The quality of induction and maintenance of anaesthesia was satisfactory in every patient.
authors.affiliation: Sir Humphry Davy Department of Anaesthesia, University of Bristol, Bristol Royal Infirmary.
authors.forename: F L
authors.initials: FL
authors.lastname: Roberts
authors.forename: J
authors.initials: J
authors.lastname: Dixon
authors.forename: G T
authors.initials: GT
authors.lastname: Lewis
authors.forename: R M
authors.initials: RM
authors.lastname: Tackley
authors.forename: C
authors.initials: C
authors.lastname: Prys-Roberts
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000008:administration & dosage*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007260:Infusion Pumps; D008875:Middle Aged; D010636:Phenols / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D015742:Propofol; D013997:Time Factors
chemical_list: D000777:Anesthetics; D010636:Phenols; D015742:Propofol