title: Opiate-like peptides. Part XI. 2-[2-phenyl-1,3-indandionyl]--amides of enkephalin analogs. Synthesis and analgesic activity.
abstract: Four enkephalin analogs containing C-terminal 2-amino-2-phenyl-1,3-indandione residue were prepared: [Met-NHPID5]--enkephalin (E3), [D-Ala2,Met-NHPID5]--enkephalin (E4), [Leu-NHPID5]--enkephalin (E5), [D-Ala2,Leu-NHPID5]--enkephalin (E6). Their analgesic activities were assayed by three in vivo tests: the "hot plate" method, the reaction to electric painful stimulus and the writhing syndrome test. Neurotoxicity effects were determined by the rota-rod test. The most pronounced analgesic effect was induced by compounds with D-Ala in position 2, particularly in the "hot plate" test.
authors.affiliation: Pedagogical Institute, Shoumen, Bulgaria.
authors.forename: H
authors.initials: H
authors.lastname: Nedev
authors.forename: K
authors.initials: K
authors.lastname: Rolka
authors.forename: S
authors.initials: S
authors.lastname: Minchev
authors.forename: G
authors.initials: G
authors.lastname: Kupryszewski
authors.forename: K
authors.initials: K
authors.lastname: Kolasa
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D004723:Endorphins / Q000138:chemical synthesis* / Q000494:pharmacology; D004745:Enkephalins / Q000031:analogs & derivatives*; D006358:Hot Temperature; D051379:Mice; D010146:Pain / Q000517:prevention & control; D010147:Pain Measurement; D011930:Reaction Time
chemical_list: D004723:Endorphins; D004745:Enkephalins