The influence of sympathomimetic and sympatholytic agents on the salivary flow rate and concentration of Ca, P and protein in the parotid gland of the goat.
1. The role of the sympathetic autonomic division on the parotid gland of normal and thyroparathyroidectomized (t.x.p.t.x.) goats was studied. 2. The salivary flow rate and concentration of Ca, P and protein was tested during the intravenous infusions of sympathomimetic and sympatholytic agents. 3. The intravenous infusion of isoprenaline modified the salivary flow rate and the concentration of total protein. 4. None of the tested drugs modified significantly the concentration of Ca and P in the parotid saliva. 5. The results obtained in normal and t.x.p.t.x animals were similar; it seems that PTH is not involved in the observed changes.
Isac
M D
MD
Department of Physiology, Faculty of Pharmacy, University of Granada, Spain.
Valverde
A
A
Lupiani
M J
MJ
Martinez De Victoria
E
E
Manas
M
M
D000818:Animals; D002118:Calcium / Q000302:isolation & purification; D006041:Goats / Q000502:physiology*; D010281:Parathyroid Hormone / Q000096:biosynthesis; D010306:Parotid Gland / Q000032:analysis* / Q000294:innervation; D011188:Potassium / Q000302:isolation & purification; D011506:Proteins / Q000302:isolation & purification; D012469:Salivary Glands / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D013565:Sympatholytics / Q000494:pharmacology*; D013566:Sympathomimetics / Q000494:pharmacology*
D010281:Parathyroid Hormone; D011506:Proteins; D013565:Sympatholytics; D013566:Sympathomimetics; D011188:Potassium; D002118:Calcium