title: Activation of protein kinase C from B lymphocytes by lipid A.
abstract: The effect of lipid A, a residue of the lipopolysaccharide molecule, on protein kinase C from B lymphocytes has been studied. Lipid A activates and promotes the translocation of protein kinase C from the soluble to the particulate membrane fraction in a cell-free system reconstituted with purified enzyme and membranes isolated from B lymphocytes. These results demonstrate that the activating effect of lipopolysaccharide on protein kinase C from B cells is due to the lipid moieties of this molecule.
authors.affiliation: Instituto de Bioquímica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Boscá
authors.forename: M J
authors.initials: MJ
authors.lastname: Díaz-Guerra
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000201:enzymology*; D004789:Enzyme Activation; D007700:Kinetics; D008050:Lipid A / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D011493:Protein Kinase C / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D008050:Lipid A; D011493:Protein Kinase C