Serum pancreatic secretory trypsin inhibitor (PSTI) in seriously injured and septic patients.
Changes of serum PSTI in 49 patients with serious injury or sepsis were investigated. The patients were divided into three groups according to the maximum serum PSTI levels. The mean maximum PSTI was 14.3 +/- 5.7 ng/ml (mean +/- SD) in Group 1 (17 patients), 61.9 +/- 25.6 ng/ml in Group 2 (19 patients) and 678.6 +/- 401.3 ng/ml in Group 3 (13 patients). Serum PSTI in Group 1 stayed within the normal range. Serum PSTI in Group 2 rose from the second or third hospital day, reached its maximum within seven days, and returned to normal thereafter. All 13 patients in Group 3 were suffering from either sepsis (8 patients) or irreversible shock (5 patients) and serum PSTI showed a remarkably high level. Judging by multiple organ failure (MOF) index, there was a significant correlation between the maximum serum PSTI and the severity of traumatic stress, tissue destruction or infection.
Tanaka
H
H
Department of Traumatology, Osaka University Medical School.
Ogawa
M
M
Yoshioka
T
T
Sugimoto
T
T
D001424:Bacterial Infections / Q000097:blood*; D006801:Humans; D010179:Pancreas / Q000378:metabolism*; D014361:Trypsin Inhibitors / Q000097:blood*; D014947:Wounds and Injuries / Q000097:blood*
D014361:Trypsin Inhibitors