Collection and use of aborted central nervous system material. Commendation and controversy.
A recent promising development in the field of central nervous system (CNS) transplantation has suggested the use of human fetal CNS tissue from first trimester abortions for xenografting/explantation. Such experiments would certainly expand our knowledge of the normal developmental mechanisms in human CNS, and allow studies of various indices of maturation and CNS function. However, the suggestion is looked upon with hesitance for ethical, legal and perhaps even for scientific reasons. The initial experiments have been very valuable, though, for our understanding of the structural and functional development of the human CNS, and several legal and ethical concerns have been addressed in working out the procedures for retrieving such tissue. This article tries to put our present knowledge in the right perspective of scientific achievements and potential, legal restrictions and ethical concerns.
Seiger
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Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden.
D000023:Abortion Applicants; D000028:Abortion, Induced; D000818:Animals; D002454:Cell Differentiation; D002470:Cell Survival; D002478:Cells, Cultured; D002490:Central Nervous System / Q000637:transplantation*; D003219:Confidentiality / Q000331:legislation & jurisprudence; D004992:Ethics, Medical; D005260:Female; D005333:Fetus; D006085:Graft Survival; D006801:Humans; D007258:Informed Consent / Q000331:legislation & jurisprudence; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D051381:Rats; D013548:Sweden; D014019:Tissue Donors; D014183:Transplantation, Heterologous; D014619:Vacuum Curettage