Lack of hybridization between Yersinia enterocolitica and HLA-B27 DNA.
No homology was observed between Yersinia enterocolitica O:3 and HLA-B27 at DNA level when Yersinia enterocolitica chromosomal probes were hybridized with human HLA-B27 positive leukocyte DNA or in the hybridization of Yersinia DNA with HLA-B27 specific probe. Our results do not exclude the existence of molecular mimicry between Yersinia proteins and HLA-B27 antigen, since the crossreactive epitope might be a conformational determinant not detected with hybridization.
Viitanen
A M
AM
Department of Medical Microbiology, Turku University, Finland.
Lahesmaa-Rantala
R
R
Weiss
E
E
Toivanen
A
A
D001170:Arthritis, Infectious / Q000209:etiology; D004247:DNA; D004269:DNA, Bacterial; D015235:HLA-B Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen; D006801:Humans; D009693:Nucleic Acid Hybridization; D012016:Reference Values; D012689:Sequence Homology, Nucleic Acid; D015009:Yersinia Infections / Q000235:genetics; D015008:Yersinia enterocolitica / Q000235:genetics*
D004269:DNA, Bacterial; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D004247:DNA