Hypergastrinaemia evoked by omeprazole stimulates growth of gastric mucosa but not of pancreas or intestines in hamster, guinea pig and chicken.
Treatment of chickens, hamsters and guinea-pigs with the long-acting anti-secretagogue omeprazole resulted in elevated levels of serum gastrin. The chickens received 400 mumol/kg by i.m. injection once daily, the hamsters and guinea-pigs received the same dose by the oral route once daily. In all 3 species omeprazole raised the intragastric pH to 4, measured 12-14 h after the administration of the drug. After 10 weeks of treatment, trophic changes were observed in the stomach of hamster and guinea pig and in the proventriculus of chicken. The trophic changes were manifested in a greatly increased stomach weight and gastric mucosal mass. There were no trophic effects outside the stomach (or proventriculus). The results are in agreement with previous observations in the rat and support the view that long-lasting sustained hypergastrinaemia causes trophic changes in the stomach but not in the pancreas or in the intestines.
Håkanson
R
R
Department of Pharmacology, University of Lund, Sweden.
Axelson
J
J
Ekman
R
R
Sundler
F
F
D000818:Animals; D002645:Chickens; D006224:Cricetinae; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D005755:Gastrins / Q000097:blood / Q000502:physiology*; D006168:Guinea Pigs; D007413:Intestinal Mucosa / Q000473:pathology; D007422:Intestines / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009853:Omeprazole / Q000633:toxicity*; D009928:Organ Specificity; D010179:Pancreas / Q000187:drug effects / Q000473:pathology*; D012016:Reference Values; D013045:Species Specificity
D005755:Gastrins; D009853:Omeprazole