Whole body hyperthermia (41-42 degrees C) induces interleukin-1 in vivo.
The role of endogenous mediated fever and exogenous hyperthermia as modulators of immunological processes against infection and neoplasms remains poorly understood. Hyperthermia appears to modulate the activity of a number of immunological cytokines including Interleukin-1 (IL-1). Using a recently developed Radiant Heat technology for safely producing 41-42 degrees C Whole Body Hyperthermia in mice, we have investigated the effect of 1 hour of 41 +/- 0.5 degrees C WBH on the production of cutaneous IL-1. After a transient fall in IL-1 production 4 hours post WBH, significant elevations (up to twice control levels) were noted with a peak at 16-20 hours post WBH. IL-1 levels remained elevated for 5-6 days post-WBH. The potential clinical significance of this finding is discussed with particular reference to human malignant melanoma.
Neville
A J
AJ
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Sauder
D N
DN
D000818:Animals; D015342:DNA Probes; D006979:Hyperthermia, Induced; D007111:Immunity, Cellular; D007375:Interleukin-1 / Q000096:biosynthesis*; D008545:Melanoma / Q000628:therapy; D051379:Mice; D012333:RNA, Messenger / Q000032:analysis; D012867:Skin / Q000032:analysis; D012878:Skin Neoplasms / Q000628:therapy
D015342:DNA Probes; D007375:Interleukin-1; D012333:RNA, Messenger