Prediction of the secondary structures of bovine blood coagulation factor IX, factor X, and prothrombin.
The secondary structures of bovine blood coagulation factors IX and X, as well as that of bovine prothrombin, were predicted on the basis of a computerized combination of the Chou-Fasman and Burgess algorithms. Refinements in the predictions were made after consideration of the content of various secondary structures, as determined by circular dichroism studies of these same proteins. The final turn assignments were in good agreement with those assigned with use of an algorithm involving pattern matching of beta-turns in proteins of known structure.
Beals
J M
JM
Department of Chemistry, University of Notre Dame, Indiana 46556.
Weber
J
J
Derwent
P
P
Grant
K L
KL
Castellino
F J
FJ
D000818:Animals; D002417:Cattle; D005164:Factor IX; D005170:Factor X; D011237:Predictive Value of Tests; D011487:Protein Conformation; D011516:Prothrombin
D011516:Prothrombin; D005164:Factor IX; D005170:Factor X