title: Changes in arterial norepinephrine concentration following intravenous administration in dogs with lung edema.
abstract: Arterial concentrations of given norepinephrine (NE) were measured after bolus administration in dogs with normal lungs and in those with oleic acid-induced lung edema. In both groups, the peak NE concentration was given by blood samples taken 30 sec after injection and the concentration showed a decreasing tendency thereafter. NE concentrations were always greater in the lung edema group than in the control group and a longer period was needed for NE concentrations to return to the baseline level. This delay in the clearance of NE from the circulation might reflect a diminished uptake by the pulmonary endothelium. This phenomenon may be used for the diagnosis of pulmonary endothelial injury.
authors.affiliation: Department of Anesthesiology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Imamura
authors.forename: A
authors.initials: A
authors.lastname: Yasuda
authors.forename: K
authors.initials: K
authors.lastname: Amaha
mesh_terms: D000818:Animals; D004285:Dogs; D007275:Injections, Intravenous; D009638:Norepinephrine / Q000097:blood / Q000493:pharmacokinetics*; D011654:Pulmonary Edema / Q000378:metabolism*
chemical_list: D009638:Norepinephrine