The mechanism by which calcium reduces blood pressure.
The mechanism by which exogenous calcium reduces blood pressure was investigated. The verapamil (300 micrograms/kg i.v.)-induced decrease of the mean arterial pressure in the conscious rat was prolonged by 400% by pretreatment with CaCl2 (300 mumol/kg i.v.). This ability of calcium to enhance the effect of verapamil was decreased by i.c.v. injection of EDTA (10 nmol/kg). In light of our previous reports, these results suggest that i.v. calcium reduces blood pressure by a central calcium-calmodulin-dependent mechanism.
Sutoo
D
D
Institute of Medical Science, University of Tsukuba, Ibaraki-Ken, Japan.
Matsukura
T
T
Akiyama
K
K
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001978:Bromphenol Blue; D002118:Calcium / Q000494:pharmacology*; D002122:Calcium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology
D001978:Bromphenol Blue; D014700:Verapamil; D002122:Calcium Chloride; D002118:Calcium