title: [Synthesis of 5-bromosalicyl-4'-chloroanilide-O-beta-D-xylopyranoside and other transport forms enzymatically activated by microbes].
abstract: The synthesis of 5-bromosalicyl-4'-chloroanilide-O-beta-D-xylopyranoside and other glycosides of 5-bromosalicyl-4'-chloroanilide, salicylanilide, 3,5-dichlorophenol and tetrachlorohydrochinone is described. Glycosidations follow the procedures described by Latham et al. Sabalitschka and Helferich et al. These glycosides represent relatively untoxic transport-forms of drugs, which are activated to the free drug by specific enzymes of the organisms to be destroyed. This new mechanisms can help to destroy fungi and parasites in dermatology, agriculture, horticulture and cultivation of decorative plants without side effects on the host.
authors.affiliation: Zentralinstitut für Krebsforschung, Akademie der Wissenschaften der DDR, Berlin-Buch.
authors.forename: K
authors.initials: K
authors.lastname: Schwabe
authors.forename: B
authors.initials: B
authors.lastname: Tschiersch
authors.forename: W
authors.initials: W
authors.lastname: Wohlrab
authors.forename: J
authors.initials: J
authors.lastname: Redslob
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004337:Drug Carriers; D004789:Enzyme Activation; D006027:Glycosides / Q000138:chemical synthesis* / Q000494:pharmacology; D012459:Salicylates / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D004337:Drug Carriers; D006027:Glycosides; D012459:Salicylates; C035836:ZIK 1392
vernacular_title: Synthese des 5-Bromsalicyl-4'-chloranilid-O-beta-D-xylopyranosids und weiterer durch Mikroben enzymatisch aktivierbarer Wirkstoff-Transportformen.