title: [The problem and value of therapy in multiple sclerosis].
abstract: Some fundamental problems of therapy in multiple sclerosis (MS) and the difficulties in assessing the results of treatment are represented. Basing on a survey of several principles of therapy, the findings of own therapeutic trials using corticosteroids, immunosuppressive agents (azathioprine, cyclophosphamide, antihumanlymphocyte globulin) are pointed out; in particular, the analysis of a longer period of the course of disease produced few favourable effects. In further therapeutic studies, i.e. plasmapheresis and immunoadsorption, a long lasting observation of the course is lacking; this likewise concerns the study on ultraviolet irradiation of blood. As to the aspects of a multi-stage pathogenesis of MS an appraisal of therapeutic conceptions and procedures is given; in critical evaluation their efficacy is little convincing.
authors.affiliation: Abteilung Neurologie, Bereiches Medizin der Wilhelm-Pieck-Universität Rostock.
authors.forename: B
authors.initials: B
authors.lastname: Hitzschke
authors.forename: H J
authors.initials: HJ
authors.lastname: Meyer-Rienecker
authors.forename: F
authors.initials: F
authors.lastname: Buddenhagen
authors.forename: M
authors.initials: M
authors.lastname: Richter
mesh_terms: D000328:Adult; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000628:therapy*; D010865:Pilot Projects; D010956:Plasmapheresis; D011239:Prednisolone / Q000627:therapeutic use; D014467:Ultraviolet Therapy
chemical_list: D000961:Antilymphocyte Serum; D003520:Cyclophosphamide; D011239:Prednisolone; D001379:Azathioprine
vernacular_title: Zur Problematik und Wertigkeit der Therapie bei Multipler Sklerose.