title: Phenazone pharmacokinetics as an index of hepatic metabolic efficiency.
abstract: Phenazone pharmacokinetics as an index of hepatic microsomal enzyme activity was studied in 31 patients with Hodgkin's disease, 11 patients with non-Hodgkin's lymphoma and 52 healthy volunteers. The mean phenazone half-life (t0.5) was significantly shorter in patients with Hodgkin's disease (8.002 +/- 2.775 h) and in patients with non-Hodgkin's lymphoma (8.775 +/- 2.440 h) than in healthy persons (11.351 +/- 3.706 h). In patients with Hodgkin's disease and in patients with non-Hodgkin's lymphoma mean elimination rate constant (Kel) (0.101 +/- 0.050 h-1; 0.086 +/- 0.028 h-1) and mean metabolic clearance rate (MCR) (70.464 +/- 50.347 ml/min; 71.621 +/- 21.448 ml/min) differed statistically significantly from the same parameters in control group, where K was 0.067 +/- 0.021 h-1 and MCR 49.361 +/- 18.167 ml/min. Treatment with antineoplastic drugs inhibited phenazone elimination. No correlations were found between the phenazone pharmacokinetics parameters and routine laboratory tests of liver function. Since many drugs are metabolized by cytochrome P-450, similar to phenazone, it is likely that their elimination in patients with Hodgkin's disease and in patients with non-Hodgkin's lymphoma will be also changed. This should be considered in selection of their dosage.
authors.affiliation: Department of Clinical Pharmacology, Medical Academy, Wroclaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Wiela
authors.forename: K
authors.initials: K
authors.lastname: Orzechowska-Juzwenko
authors.forename: S
authors.initials: S
authors.lastname: Kotlarek-Haus
authors.forename: B
authors.initials: B
authors.lastname: Plamieniak
authors.forename: D
authors.initials: D
authors.lastname: Wolowiec
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D000983:Antipyrine / Q000493:pharmacokinetics*; D005260:Female; D006689:Hodgkin Disease / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008111:Liver Function Tests; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D000983:Antipyrine