Membrane antioxidants.
In this chapter, I have discussed both lipid-soluble and water-soluble antioxidants that exert protective action with respect to inhibiting lipid, and in some cases, protein oxidation in both natural and artificial membranes. In addition, recent work has begun to clarify exactly how antioxidant enzymes can protect membranes against peroxidative damage. Although we have some understanding of the mechanisms of several of these antioxidants, much work remains to be done before we can begin making dietary recommendations that may have profound implications with respect to aging, cancer, and the many other human diseases that have been associated with radical-induced damage.
Krinsky
N I
NI
Department of Biochemistry, Tufts University Health Sciences Campus, Boston, Massachusetts 02111.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001663:Bilirubin / Q000494:pharmacology; D002338:Carotenoids / Q000494:pharmacology; D002462:Cell Membrane / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000502:physiology; D006801:Humans; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D014810:Vitamin E; D002338:Carotenoids; D005979:Glutathione Peroxidase; D001205:Ascorbic Acid; D001663:Bilirubin