Anti-inflammatory effect of glutathione peroxidase on experimental lens-induced uveitis.
An acute lens-induced necrotizing intraocular inflammation was produced in Lewis rats. Treatment of these animals by intraperitoneal injection of glutathione peroxidase resulted in marked decrease in uveal inflammation, retinal edema, hemorrhage and vasculitis. Intraperitoneal injection of glutathione peroxidase resulted in increased levels of this enzyme in ocular tissue. These findings suggest that glutathione peroxidase can modulate acute lens-induced ocular inflammation by serving as a potent anti-inflammatory agent.
Rao
N A
NA
Estelle Doheny Eye Foundation, University of Southern California, Los Angeles.
Romero
J L
JL
Sevanian
A
A
Fernandez
M A
MA
Wong
C
C
Ward
P A
PA
Marak
G E
GE
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002829:Choroid / Q000473:pathology; D005123:Eye / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000378:metabolism / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007908:Lens, Crystalline / Q000502:physiology*; D051381:Rats; D011917:Rats, Inbred Lew; D012160:Retina / Q000473:pathology; D012164:Retinal Diseases / Q000209:etiology; D012171:Retinal Vessels; D014605:Uveitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
D000893:Anti-Inflammatory Agents; D005979:Glutathione Peroxidase