Peripheral and central satiety factors in neuropeptide Y-induced feeding in rats.
In the first study, injection of NPY into the hypothalamic paraventricular nucleus (PVN) caused a robust feeding effect that was attenuated by intravenous infusions of glucose, but not fructose. It is suggested that increased blood glucose has a direct central effect on NPY feeding mechanisms. In a second study, and contrary to a previous report, peripheral administration of CCK-8 had a marked satiety effect in NPY-treated rats. Thus, NPY-induced feeding is, at least for a short time, possibly subject to the satiating action of prandially-released CCK. In a final study, NPY was shown to be without effect on gastric emptying of a solid test meal.
Rowland
N E
NE
Department of Psychology, University of Florida, Gainesville 32611.
D000818:Animals; D004435:Eating / Q000187:drug effects*; D005632:Fructose / Q000494:pharmacology; D005746:Gastric Emptying / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology; D007267:Injections; D008297:Male; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000494:pharmacology*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012527:Satiation; D012528:Satiety Response; D012844:Sincalide / Q000494:pharmacology
D009478:Neuropeptide Y; D005632:Fructose; D005947:Glucose; D012844:Sincalide