title: [Relative role of selective migration and pathology in the formation of genetic structure].
abstract: It is shown that elective migration, with respect to polymorphic loci genotypes, and their association with pathology affect unequally formation of genetic structure features of the population analysed. The correlative role of two processes mentioned is more or less specific, with respect to every concrete locus: the elective migration and the pathology have unidirectional impact in all groups, which leads to maximum dynamics of genotypes in groups with different duration of dwelling under extreme conditions (AcP, Pp loci). These processes act as antagonists, preserving constant genotype frequency (AK locus). Genotype frequency dynamics is mainly determined by the elective migration (Rh locus) or the pathology (PGD locus). The correlative role of the elective migration and the pathology is often unequal in groups with different duration of dwelling under the North-East conditions, as applied to concrete locus (GLO-1, PGM1), though the elective migration participates in groups with comparatively small dwelling-term in the North and the pathology has more influence as this term increases. The problem of genetic aspects of human adaptation is under discussion.
authors.forename: L L
authors.initials: LL
authors.lastname: Solovenchuk
mesh_terms: D000222:Adaptation, Physiological; D001110:Arctic Regions; D005828:Genetics, Population; D006801:Humans; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic; D012800:Siberia; D013997:Time Factors
vernacular_title: Sootnositel'naia rol' izbiratel'noĭ migratsii i patologii v formirovanii osobennosteĭ geneticheskoĭ struktury.