On reference values for tumor markers in prostatic carcinoma.
Serum contents of prostatic acid phosphatase, neopterin, osteocalcin, tissue polypeptide antigen and CA-50 were measured before onset of treatment in 83 patients suffering from prostatic carcinoma. In an attempt to identify patients with poor prognosis the data were related to patient survival after 2 years. It was found that the standard cut off values, obtained from the upper limits of normal, healthy subjects, were sensitive but had low specificity. A better relation to prognosis was usually found at a higher discrimination limit. The degree of elevation appears more important than the elevation of the markers as such in indicating a poor prognosis. By systematic adjustment of the discrimination levels, higher specificity can be obtained with little loss of sensitivity.
Lewenhaupt
A
A
Department of Urology, Huddinge Hospital, Stockholm, Sweden.
Ekman
P
P
Eneroth
P
P
Kallner
A
A
D000135:Acid Phosphatase / Q000097:blood; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D014408:Biomarkers, Tumor / Q000097:blood*; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D002135:Calcium-Binding Proteins / Q000097:blood; D006801:Humans; D008297:Male; D019798:Neopterin; D015675:Osteocalcin; D010455:Peptides / Q000032:analysis; D011471:Prostatic Neoplasms / Q000097:blood*; D012016:Reference Values; D019396:Tissue Polypeptide Antigen; D014812:Vitamin K / Q000097:blood
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D010455:Peptides; D019396:Tissue Polypeptide Antigen; D015675:Osteocalcin; D014812:Vitamin K; D001708:Biopterins; D019798:Neopterin; D000135:Acid Phosphatase