Treatment of lupus nephritis with total lymphoid irradiation. Observations during a 12-79-month followup.
Seventeen patients with intractable lupus nephritis and nephrotic syndrome were treated with total lymphoid irradiation. Statistically significant improvement in mean renal disease and serologic activity parameters occurred within 3 months and persisted for at least 3 years. Although there was a marked reduction of T helper cell numbers and function after total lymphoid irradiation, recovery of these parameters was not associated with a return of disease activity. Risks of sterility, severe infections, and hematologic malignancy appeared to be lower than with alkylating agents.
Strober
S
S
Department of Medicine, Stanford University School of Medicine, California.
Fariñas
M C
MC
Field
E H
EH
Solovera
J J
JJ
Kiberd
B A
BA
Myers
B D
BD
Hoppe
R T
RT
D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D008181:Lupus Nephritis / Q000276:immunology / Q000503:physiopathology / Q000532:radiotherapy*; D008221:Lymphoid Tissue; D008297:Male; D011832:Radiation Injuries; D013601:T-Lymphocytes / Q000145:classification / Q000502:physiology; D013997:Time Factors
D007136:Immunoglobulins