The relationship between anti-Ro (SS-A) antibody-positive Sjögren's syndrome and anti-Ro (SS-A) antibody-positive lupus erythematosus.
Ten Ro(SS-A) antibody-positive patients with Sjögren's syndrome and lupus erythematosus are described. These patients have a disease process characterized by the frequent appearance of annular polycyclic lupus lesions of subacute cutaneous lupus erythematosus (SCLE), as well as neurologic and pulmonary disease. The Ro(SS-A) antibody-positive patients may have Sjögren's syndrome for many years and then suddenly develop lupus erythematosus, and vice versa. These studies demonstrate that the patient with Ro(SS-A) antibody may exhibit a dynamic clinical disease expression over time and that there is a closer pathologic relationship between Sjögren's syndrome and SCLE in these patients with Ro(SS-A)-antibody than has previously been appreciated. Furthermore, Ro(SS-A)-positive patients with Sjögren's syndrome and lupus erythematosus appear to have a much more guarded prognosis than those Ro(SS-A)-positive lupus patients described under the classifications of antinuclear antibody-negative lupus erythematosus and SCLE.
Provost
T T
TT
Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
Talal
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N
Harley
J B
JB
Reichlin
M
M
Alexander
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E
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D008431:Maternal-Fetal Exchange; D008875:Middle Aged; D011247:Pregnancy; D011379:Prognosis; D012859:Sjogren's Syndrome / Q000150:complications / Q000276:immunology* / Q000503:physiopathology
D000974:Antibodies, Antinuclear; C035356:SS-A antibodies; C035357:SS-B antibodies