Effects of piperine on calcitonin gene-related peptide (CGRP)-containing nerves in the isolated rat atria.
Piperine, a major pungent agent of black peppers, induced both positive chronotropic and inotropic responses in the isolated atria of rats. These responses were not blocked by various antagonists but exhibited rapid tachyphylaxis. After exposure to piperine in vitro, endogenous calcitonin gene-related peptide (CGRP) was profoundly depleted from intracardiac nerves. These results suggest that piperine releases endogenous CGRP from intracardiac non-adrenergic non-cholinergic nerves and that released CGRP exerts positive chronotropic and inotropic effects.
Miyauchi
T
T
Department of Internal Medicine, University of Tsukuba, Japan.
Ishikawa
T
T
Sugishita
Y
Y
Saito
A
A
Goto
K
K
D000470:Alkaloids; D000818:Animals; D052117:Benzodioxoles; D015740:Calcitonin Gene-Related Peptide; D006325:Heart Atria / Q000187:drug effects / Q000294:innervation* / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009479:Neuropeptides / Q000378:metabolism*; D010525:Peripheral Nerves / Q000187:drug effects / Q000378:metabolism*; D010880:Piperidines / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides; D051381:Rats; D011919:Rats, Inbred Strains
D000470:Alkaloids; D052117:Benzodioxoles; D009479:Neuropeptides; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D015740:Calcitonin Gene-Related Peptide; C008922:piperine