Elimination from rat circulation of goat and sheep haptoglobin and their complexes with rat haemoglobin.
The rate of elimination from rat circulation of 125I-labelled human, goat and sheep haptoglobin, and their complexes with rat haemoglobin was studied. The clearance of human haptoglobin-rat haemoglobin complex from rat circulation was about 5 times faster than that of free haptoglobin. For sheep and goat haptoglobin and their complexes with rat haemoglobin the rate of elimination was identical, the half-life time t 1/2 ranging from 8 to 9 h.
Osada
J
J
Department of Pharmaceutical Biochemistry Medical Academy, Szewska, Wrocław.
D000818:Animals; D001667:Binding, Competitive; D001775:Blood Circulation; D006041:Goats; D006242:Haptoglobins / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007457:Iodine Radioisotopes; D051381:Rats; D012636:Secretory Rate; D012756:Sheep; D013045:Species Specificity
D006242:Haptoglobins; D006454:Hemoglobins; D007457:Iodine Radioisotopes