The effect of frontal cortex lesion on the activity of the dopaminergic system in rat striatum.
The experiment was carried out on male Wistar rats weighing 180-220 g with lesion in the cortex of the frontal lobe. The activity of the dopaminergic system was studied by means of behavioural tests such as determination of spontaneous motor activity, apomorphine-induced stereotypy, haloperidol-induced catalepsy. Increased intensity of stereotypy was observed reaching a maximum 14 days after frontal lobe damage. Moreover, a slight tendency was observed for inhibition of haloperidol-induced catalepsy without changes in the spontaneous motor activity of the animals. Biochemical investigations demonstrated reduced dopamine content in the striatum on the side of the lesion.
Sieklucka-Dziuba
M
M
Department of Pharmacology, School of Medicine, Lublin.
Wamil
A
A
Kleinrok
Z
Z
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004298:Dopamine