title: Comparison between propofol and midazolam as sedative agents for surgery under regional anaesthesia.
abstract: Propofol (25 patients) or midazolam (25 patients) was used to provide sedation in patients who underwent abdominal or orthopaedic surgery under epidural anaesthesia after intravenous premedication with droperidol 1 mg and fentanyl 20 micrograms. The quality of sedation whilst the block was performed, was assessed as good in 19 patients after propofol 1.49 mg/kg but six patients exhibited uncontrolled movement. Good sedation was provided in 22 patients after midazolam 3 mg. A mean infusion rate of propofol of 1.74 mg/kg/hour resulted in easily controllable sedation during the procedure. Eleven patients given midazolam required no further sedation but a mean of 5.79 mg was needed in the remaining 14 patients; the dose was unpredictable in individual patients. Recovery was significantly more rapid in the propofol group.
authors.affiliation: Department of Anaesthesia, Clinique Ste-Anne, Brussels, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Fanard
authors.forename: A
authors.initials: A
authors.lastname: Van Steenberge
authors.forename: X
authors.initials: X
authors.lastname: Demeire
authors.forename: F
authors.initials: F
authors.lastname: van der Puyl
mesh_terms: D000293:Adolescent; D000328:Adult; D000767:Anesthesia, Epidural; D004329:Droperidol; D005260:Female; D005283:Fentanyl; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D008297:Male; D008874:Midazolam / Q000008:administration & dosage; D008875:Middle Aged; D010636:Phenols / Q000008:administration & dosage; D011229:Preanesthetic Medication; D015742:Propofol; D013514:Surgical Procedures, Operative
chemical_list: D006993:Hypnotics and Sedatives; D010636:Phenols; D004329:Droperidol; D008874:Midazolam; D005283:Fentanyl; D015742:Propofol