[Influence of ethacizin (the diethyl analog of ethmozine) on phase-dependent parasympathetic effects on the heart].
The influence of ethacizin (a diethylamine analog of ethmozine) (1.10(-7)-1.10(-6) g/ml) upon the phase-dependent chronotropic parasympathetic effects was studied on the perfused frog heart. The vagolytic influence of ethacizin (5.10(-7) and 1.10(-6) g/ml) was detected; the concentration of 1.10(-7) g/ml was found ineffective. The vagolytic effect consisted of a decreased maximum of phase-dependent effect, reduced latency and time required for the manifestation of the maximum increase. The period of inhibitory vagal stimulus effectiveness did not change significantly.
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D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D016293:Moricizine / Q000031:analogs & derivatives*; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D010640:Phenothiazines / Q000494:pharmacology*; D011896:Rana temporaria; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; C027240:diethylamino-ethmozine; D016293:Moricizine
Vliianie étatsizina (dietilovogo analoga étmozina) na fazozavisimye parasimpaticheskie éffekty na serdtse.