[The possibilities of selecting an adequate therapy of systemic lupus erythematosus based on the results of HLA typing].
In order to find out the most suitable treatment for systemic lupus erythematodes the frequency of various antigens in the locus A and B of the system HLA was examined in various clinical subgroups of patients with systemic lupus erythematodes. A correlation was established between the group of patient treated intensively and the antigens HLA-A11, HLA-B18, HLA-B8. The antigens HLA-B35 and HLA-B5 were associated with the group of patients treated with a moderately intensive treatment for systemic lupus erythematodes. The patients with systemic lupus erythematodes with antigens HLA-A11, HLA-B18 and HLA-B8 should be actively treated from the onset of the disease in order to avoid severe lesions of the kidneys and the CNS and the polysyndrome clinical manifestations.
Lesniak
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OM
D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D003422:Critical Care; D005260:Female; D006680:HLA Antigens / Q000032:analysis* / Q000145:classification; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000628:therapy*; D008875:Middle Aged
D006680:HLA Antigens
Vŭrkhu vŭzmozhnostite za izbor na adekvatna terapiia na sistemniia lupus erythematodes vŭz osnova na rezultatite ot HLA tipiziraneto.