title: Comparison of miocamycin versus amoxycillin in lower respiratory tract infections in children. Clinical response and effect on natural killer activity.
abstract: The clinical efficacies of 50 mg/kg.day miocamycin and 60 mg/kg.day amoxycillin were studied in 23 patients aged 3-11.5 years with presumed bacterial infection of the lower respiratory tract (bronchopneumonia and acute bronchitis). During the therapy, which continued for 10 days, non-specific immune function, represented by natural killer cell activity, was monitored by measurement of the rate of lysis induced on target K-562 51Cr-labelled tumour cells. The results confirmed the therapeutical efficacy of miocamycin and amoxycillin in the oral therapy of bronchopneumonia and acute bronchitis in paediatric patients. The natural killer cell activity of patients treated with miocamycin was increased on days 7 and 10 of therapy compared with baseline. This finding did not occur in patients treated with amoxycillin.
authors.affiliation: Paediatric Clinic V, S. Paulo Hospital, University of Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Agostoni
authors.forename: M
authors.initials: M
authors.lastname: Giovannini
authors.forename: F
authors.initials: F
authors.lastname: Fraschini
authors.forename: F
authors.initials: F
authors.lastname: Scaglione
authors.forename: C
authors.initials: C
authors.lastname: Galluzzo
authors.forename: E
authors.initials: E
authors.lastname: Riva
authors.forename: F
authors.initials: F
authors.lastname: Ferrara
mesh_terms: D000208:Acute Disease; D000658:Amoxicillin / Q000627:therapeutic use*; D001991:Bronchitis / Q000188:drug therapy; D001996:Bronchopneumonia / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects*; D007933:Leucomycins / Q000627:therapeutic use*; D008297:Male; D015644:Miocamycin; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000276:immunology
chemical_list: D007933:Leucomycins; D015644:Miocamycin; D000658:Amoxicillin