Effect of some benzamide derivatives on stress-induced behavior and striatum dopamine receptors.
The effects of a new benzamide derivative LIS-630 and the well-known neuroleptic, tiapride, were studied on stress-induced hyper- and hypoactive emotional behavioral reaction of animals depending on the individual ability for perceptive-cognitive activity in stress situations, and their affinity to striatal DA receptors. A modified variant of forced swimming method was used. The affinity of the substances to striatal DA receptors was studied by the radioligand binding method using 3H-spiroperidol. The results show that the psychopharmacological profile of LIS-630 differs significantly from the neuroleptic, tiapride. LIS-630 restored escape behavior from stress situation after preliminary exposure of rats to forced swimming and did not disturb escape behavior in animals more resistant to emotional hypoactivity. LIS-630 reduced immobility time at forced swimming. However, it is not effective in preventing hyperemotional reactions induced by L-dopa and stress. The radioligand binding study shows that LIS-630 did not displace 3H-spiroperidol from the binding sites of striatum membranes. The parameters of displacement with tiapride were satisfactory.
Bondarenko
N A
NA
Chemical Pharmaceutical Research Institute, Sofia, Bulgaria.
Gorantcheva
J
J
Tyutyulkova
N
N
Nikolova
M
M
Valdman
A V
AV
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001549:Benzamides / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism*; D007103:Immobilization; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D009025:Morpholines / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D013134:Spiperone / Q000378:metabolism; D013315:Stress, Psychological / Q000523:psychology*; D013976:Tiapamil Hydrochloride / Q000494:pharmacology
D001549:Benzamides; D009025:Morpholines; D011954:Receptors, Dopamine; D007980:Levodopa; D013134:Spiperone; C059049:befol; D013976:Tiapamil Hydrochloride