Release of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) from organs of the genitourinary tract in rats.
Calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) was detected in the rat urinary bladder, ureter and vas deferens and was depleted by systemic capsaicin desensitization. Exposure to capsaicin in vitro produced a prompt increase in CGRP-LI outflow in superfusates of these tissues, while a second application of the drug was ineffective indicating desensitization. These findings provide further evidence for a transmitter role of CGRP from peripheral endings of sensory nerves and the involvement of CGRP-LI in the specific motor response to capsaicin in the rat genitourinary tract.
Santicioli
P
P
Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
Maggi
C A
CA
Geppetti
P
P
Del Bianco
E
E
Theodorsson
E
E
Meli
A
A
D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin / Q000494:pharmacology; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014566:Urogenital System / Q000187:drug effects / Q000294:innervation* / Q000378:metabolism
D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin