5-Aminobenzimidazole inhibits gastric acid secretion in Shay-rats.
Benzimidazole and some of its derivatives as 4-nitro and 5-nitro-benzimidazoles, 2-amino-, 4-amino- and 5-aminobenzimidazoles have been tested on gastric acid secretion in Shay-rats. Only 5-aminobenzimidazole decreased the gastric secretory process basal or stimulated by betazole. The antisecretory properties of 5-aminobenzimidazole seem to be linked to an anti H2-histamine activity, since this compound depresses the amplitude of contractions of guinea pig isolated auricle stimulated by betazole. The antisecretive activity appears to be associated to a definite distance between the amino group and the imidazolyl nitrogen, since it appears only when the amino function is located in position 5 of the benzimidazole structure.
Trivulzio
S
S
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan.
Colombo
R
R
Rossoni
G
G
Caironi
E
E
D000818:Animals; D016275:Atrial Function; D001562:Benzimidazoles / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013329:Structure-Activity Relationship
D001562:Benzimidazoles; C059092:5-aminobenzimidazole