Relationship between central cholinergic and GABAergic neurotransmitters activity in the steroid treated rat.
Contraceptive steroid treatment to female rat alters the concentration of acetylcholine and gamma-aminobutyric acid, though not uniformly in most of the brain areas, i.e. in cerebellum, medulla oblongata-pons, hypothalamus, striatum-hippocampus, midbrain-thalamus-subthalamus, and cortex. Both neutrotransmitters vary conjointly in the hypothalamus and striatum-hippocampus after combined steroid treatment. This may indicate a concerted effect on the modulation of gonadotrophin release.
Das
P C
PC
Department of Physiology, Calcutta University, College of Sciences and Technology, India.
Dey
C D
CD
Pharikal
K
K
Dasgupta
S
S
D000109:Acetylcholine / Q000032:analysis*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D009644:Norgestrel / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000032:analysis*
D003278:Contraceptives, Oral, Hormonal; D009644:Norgestrel; D004997:Ethinyl Estradiol; D005680:gamma-Aminobutyric Acid; D019304:Ethinyl Estradiol-Norgestrel Combination; D000109:Acetylcholine