title: Regulation of the pentose phosphate cycle in bass (Dicentrarchus labrax L.) liver.
abstract: The influence in the activities of the glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase produced by the ratio changes NADPH/NADP is studied. The intracellular ratios of 20 and 10 are enough to achieve total inhibition of these two enzymes, respectively. Measurements of a number of metabolic intermediates show that the concentrations of Krebs cycle compounds are higher than those of glycolytic pathway metabolites. From a consideration of these values, the regulation of the pentose phosphate cycle mainly by the intracellular NADPH/NADP ratio, is discussed.
authors.affiliation: Departamento de Bioquímica, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain.
authors.forename: M M
authors.initials: MM
authors.lastname: Medina-Puerta
authors.forename: M
authors.initials: M
authors.lastname: Gallego-Iniesta
authors.forename: A
authors.initials: A
authors.lastname: Garrido-Pertierra
mesh_terms: D000818:Animals; D001492:Bass; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D009249:NADP / Q000378:metabolism*; D010427:Pentose Phosphate Pathway; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism*
chemical_list: D009249:NADP; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase