Lymphocyte-mediated regulation of platelet activation during desensitization in patients with hymenoptera venom hypersensitivity.
T cells from peripheral blood of hymenoptera sensitive patients were studied before and after venom desensitization. Before treatment, T cells showed a variable but higher proliferative response to allergen than T cells of treated patients or controls. While before desensitization, T cell products, specifically released after in vitro allergen stimulation, were able to amplify the IgE-dependent platelet activity, we showed that after treatment of the same patients, T cell products strongly reduced platelet activation. Considering the modifications in platelet activation previously observed in patients treated by specific immunotherapy, the present results suggest that, through a modification of T cell reactivity to allergen, T cell functions are modulated by desensitization, and emphasize the involvement of T cell products in the desensitization mechanisms.
Ledru
E
E
Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France.
Pestel
J
J
Tsicopoulos
A
A
Joseph
M
M
Wallaert
B
B
Tonnel
A B
AB
Capron
A
A
D000293:Adolescent; D000328:Adult; D000707:Anaphylaxis / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D000818:Animals; D001792:Blood Platelets / Q000276:immunology*; D002455:Cell Division; D003888:Desensitization, Immunologic; D006801:Humans; D006927:Hymenoptera; D007299:Insect Bites and Stings / Q000150:complications*; D008214:Lymphocytes / Q000473:pathology; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*