A comparative study of behavioural and autonomic effects of atropine and Atropa belladonna.
Atropa belladonna L. (Solanaceae) tincture was compared with atropine for its anticholinergic activity, both in vivo and in vitro. In all tests, the biological activity of A. belladonna resulted greater than that suggested by its alkaloid content. The results suggest the presence in A. belladonna leaves of unknown compounds with a significant biological activity.
Mazzanti
G
G
Institute of Pharmacology and Pharmacognosy, University of Rome La Sapienza, Italy.
Tita
B
B
Bolle
P
P
Bonanomi
M
M
Piccinelli
D
D
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D001532:Atropa belladonna; D001285:Atropine / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000633:toxicity; D001337:Autonomic Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010095:Oxotremorine / Q000494:pharmacology; D010276:Parasympatholytics / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D010947:Plants, Toxic; D012601:Scopolamine / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000633:toxicity
D000470:Alkaloids; D001337:Autonomic Agents; D010276:Parasympatholytics; D010936:Plant Extracts; D010095:Oxotremorine; D001285:Atropine; D012601:Scopolamine