Evaluation of single-dose ciprofloxacin in the eradication of Neisseria meningitidis from nasopharyngeal carriers.
The ability of a single oral 750-mg dose of ciprofloxacin to eradicate Neisseria meningitidis from persistent nasopharyngeal carriers was prospectively evaluated in a placebo-controlled, randomized, double-blinded study. Cultures of specimens taken from all 23 ciprofloxacin-dosed subjects 1 day postdose were negative; cultures from 96% of these subjects were negative at 7 and 21 days postdose, including a specimen from a subject colonized with a minocycline-resistant strain. Of 22 placebo recipients, 20 (91%) remained culture positive. Single-dose ciprofloxacin appears efficacious for meningococcal prophylaxis.
Dworzack
D L
DL
Department of Medical Microbiology, Creighton University, Omaha, Nebraska 68178.
Sanders
C C
CC
Horowitz
E A
EA
Allais
J M
JM
Sookpranee
M
M
Sanders
W E
WE
Ferraro
F M
FM
D002353:Carrier State / Q000382:microbiology / Q000517:prevention & control*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004341:Drug Evaluation; D006801:Humans; D008585:Meningitis, Meningococcal / Q000382:microbiology / Q000517:prevention & control*; D009305:Nasopharynx / Q000187:drug effects / Q000382:microbiology*; D010919:Placebos; D011897:Random Allocation
D010919:Placebos; D002939:Ciprofloxacin