Dissolution rate studies from a stationary disk/rotating fluid system.
The dissolution rates for hydrocortisone alcohol and acetate were determined using a stationary disk/rotating fluid system. The hydrocortisone was compressed in a tablet die, and the die placed in a vessel above a rotating magnetic bar. Dissolution rates were evaluated in aqueous media under conditions involving the following independent variables: solubility (Cs), diffusion coefficient (D), viscosity (v), rotational speed (omega), and tablet radius (r). A design equation which relates dissolution rate (R) to these variables was formulated for the system R alpha Cs D2/3 (v) -1/6(omega)1/2(r)3/2 This design equation adequately represents the system, which is related to fluid mechanics and convective diffusion models. The fluid mechanics model assumes that the fluid ideally rotates as solid-body rotation and the momentum layer is initiated at the outside radius of the tablet die. The convective diffusion model is based on the formation of a diffusion layer at the outside radius of the dissolving surface and a predictable relationship between the momentum and the mass transport quantities of bulk viscosity and diffusion coefficient. This configuration, like the rotating disk in a stationary fluid, offers the attractive attribute of being useful to study drug release mechanisms for systems of pharmaceutical interest.
Khoury
N
N
School of Pharmacy, West Virginia University, Morgantown 26506.
Mauger
J W
JW
Howard
S
S
D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D006854:Hydrocortisone / Q000032:analysis; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical; D014783:Viscosity
D013607:Tablets; D006854:Hydrocortisone