Resolution of experimental microvascular vasoconstriction in rats by topical application of lidocaine hydrochloride in varying concentrations.
Various lidocaine hydrocholoride concentrations were used to measure the degree of resolution of ergotamine-induced vasospasm of the rat tail artery. Also further studies are indicated; 12% lidocaine seems to be as effective as 20% lidocaine. The widely used 2% lidocaine had little effect on the experimentally induced vasospasm.
Beekman
W H
WH
Department of Plastic and Reconstructive Surgery, Academic Hospital Dijkzigt, Rotterdam, the Netherlands.
Sluimers
J E
JE
Kort
W J
WJ
van der Meulen
J C
JC
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004878:Ergotamine / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013623:Tail / Q000098:blood supply; D014661:Vasoconstriction / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*
D008012:Lidocaine; D004878:Ergotamine