Influence of thymus factor (TFX "Polfa") on migration of granulocytes in vivo and in vitro in patients treated for a long time with corticosteroids.
The test of leukocyte migration was carried out in vitro and in vivo in 162 patients suffering from chronic bronchitis with bronchospasm, who had been treated with corticosteroids for long time periods. Half of the patients were given TFX "Polfa" besides corticosteroids. TFX was found to have no effect on the leukocyte migration ability in vivo and in vitro. However, a significant improvement was observed in the clinical state of the patients taking TFX.
Matusiewicz
R
R
First Department of Internal Diseases, Grochów Hospital, Warsaw.
Waśniewski
J
J
D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D001991:Bronchitis / Q000188:drug therapy* / Q000276:immunology; D002464:Cell Migration Inhibition; D005260:Female; D006098:Granulocytes / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013949:Thymus Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors
D000305:Adrenal Cortex Hormones; C019108:TFX; D013949:Thymus Extracts