T-cell acute lymphoblastic leukemia with translocation (1;18).
A case of T-cell acute lymphoblastic leukemia with a translocation between chromosomes #1 and #18 is described. The breakpoints were at bands 1q23 and 18q21. A single cell contained the translocation t(1;19)(q23;p13). The breakpoint on chromosome #1 was the same in both translocations, and the breakpoint on chromosome #18 was the same as that in t(14;18)(q32;q21) associated with follicular lymphoma. The possible relationship between chromosome bands 1q23 and 18q21 and the morphologic features of the leukemia cells is discussed.
Suciu
S
S
Department Oncology-Hematology, Medical University Clinic, Hamburg, Germany.
Weh
H J
HJ
Hossfeld
D K
DK
D000293:Adolescent; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002887:Chromosomes, Human, Pair 18; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics*; D013601:T-Lymphocytes; D014178:Translocation, Genetic
D005819:Genetic Markers