title: [Cooperative inactivation of glutamate dehydrogenase of 2,2,6,6- tetramethyl-4-oxopiperidine-1-oxyl. Interpretation of results within the scope of a hexamer model with equivalent subunit orientation].
abstract: It was shown that the blockage of epsilon-amino group of Lis-126 residue by 2,2,6,6-tetramethyl-4-oxo-piperidine-1-oxyl (TMPO) leads to the cooperative inactivation of glutamate dehydrogenase (L-glutamate-NAD(P)-oxidoreductase, EC 1.4.1.3). The data concerning cooperative inactivation of the enzyme are interpreted by the model of hexamer with identical orientation of subunits. It was shown that the modification of any of enzyme subunits is accompanied by an inactivation of the hexamer's fragment which is a dimer, with subunits interacting reciprocally by means of isological contacts.
authors.forename: L V
authors.initials: LV
authors.lastname: Karabashian
authors.forename: S A
authors.initials: SA
authors.lastname: Agadzhanian
mesh_terms: D000818:Animals; D002417:Cattle; D002853:Chromatography, Liquid; D003497:Cyclic N-Oxides / Q000494:pharmacology*; D005969:Glutamate Dehydrogenase / Q000037:antagonists & inhibitors*; D046911:Macromolecular Substances; D008954:Models, Biological; D013056:Spectrophotometry, Ultraviolet; D014216:Triacetoneamine-N-Oxyl / Q000494:pharmacology*
chemical_list: D003497:Cyclic N-Oxides; D046911:Macromolecular Substances; D014216:Triacetoneamine-N-Oxyl; D005969:Glutamate Dehydrogenase
vernacular_title: Kooperativnaia inaktivatsiia glutamatdegidrogenazy 2,2,6,6- tetrametil-4-oksopiperidin-1-oksilom. Interpretatsiia resul'tatov v ramkakh modeli geksamera s ékvivalentnoĭ orientatsieĭ sub''edinits.