5-Aminosalicylic acid in patients with ulcerative colitis in remission: plasma levels after administration of a new rectal enema.
Plasma levels of total 5-aminosalicylic acid (5-ASA) were determined after a single administration of 2 g and 4 g 5-ASA enemas to 6 patients with ulcerative colitis. The mean plasma levels and AUC values confirmed that the active substance is poorly absorbed by rectal route.
Gionchetti
P
P
Istituto di Clinica Medica e Gastroenterologia, Policlinico S. Orsola, Bologna, Italy.
Belluzzi
A
A
Campieri
M
M
Torresan
F
F
Tabanelli
G M
GM
Brignola
C
C
Miglioli
M
M
Barbara
L
L
D000328:Adult; D000636:Aminosalicylic Acids / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000378:metabolism*; D004733:Enema; D005260:Female; D006801:Humans; D008297:Male; D019804:Mesalamine; D008875:Middle Aged
D000636:Aminosalicylic Acids; D019804:Mesalamine