Stimulation of B-cell progenitors by cloned murine interleukin-7.
The events involved in the commitment and development of lymphoid lineage cells are poorly understood. We have used a recently described long-term culture system to establish a bioassay that can detect a novel growth factor capable of stimulating the proliferation of lymphoid progenitors. Using direct expression in mammalian cells we have isolated a complementary DNA clone encoding this novel haematopoietic growth factor, designated interleukin-7.
Namen
A E
AE
Immunex Corporation, Seattle, Washington 98101.
Lupton
S
S
Hjerrild
K
K
Wignall
J
J
Mochizuki
D Y
DY
Schmierer
A
A
Mosley
B
B
March
C J
CJ
Urdal
D
D
Gillis
S
S
D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D001483:Base Sequence; D002454:Cell Differentiation / Q000187:drug effects*; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D015851:Interleukin-7; D007378:Interleukins / Q000235:genetics / Q000494:pharmacology*; D051379:Mice; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics
D015851:Interleukin-7; D007378:Interleukins; D012333:RNA, Messenger; D004247:DNA