A translocation t(9;11)(p11;q23) in T-cell acute lymphoblastic leukemia (FAB-l2).
We here report a t(9;11)(p11;q23) as the only abnormality in the affected cells of a 20-year-old male with acute lymphoblastic leukemia (L2) of T-cell origin. One hundred six patients with acute leukemia and involvement of band 11q23 were reviewed. Young age, hyperleukocytosis, and poor prognosis characterized almost all the cases in the acute leukemias with the 11q23 translocation, despite involvement of different recipient chromosomes and different morphologic and immunologic phenotypes.
Fan
Y S
YS
Department of Genetics and Endocrinology, Roswell Park Memorial Institute, Buffalo, New York.
Rowe
J M
JM
Dal Cin
P D
PD
Sandberg
A A
AA
D000328:Adult; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D002899:Chromosomes, Human, Pair 9; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics*; D008297:Male; D013601:T-Lymphocytes; D014178:Translocation, Genetic
D005819:Genetic Markers