Increased frequency of HLA-A3 in subjects with sporadic porphyria cutanea tarda.
The HLA-A3 alloantigen, usually associated with the hemochromatosis gene, was detected in 12 of 18 patients (67%) with sporadic porphyria cutanea tarda but in only 23 per cent of 328 normal subjects (p = 0.0006). This difference remained significant after correcting for the number of HLA-A locus antigens tested (p = 0.025). These results suggest that an HLA-linked hemochromatosis allele is present and may account for the iron abnormalities in many patients with sporadic porphyria cutanea tarda.
Edwards
C Q
CQ
Department of Medicine, University of Utah College of Medicine, Salt Lake City.
Griffen
L M
LM
Kushner
J P
JP
D006680:HLA Antigens / Q000032:analysis*; D015791:HLA-A3 Antigen; D006432:Hemochromatosis / Q000235:genetics; D006801:Humans; D007519:Isoantigens / Q000032:analysis*; D011164:Porphyrias / Q000276:immunology*; D012871:Skin Diseases / Q000276:immunology*
D006680:HLA Antigens; D015791:HLA-A3 Antigen; D007519:Isoantigens