title: Urinary excretion kinetics of p-nitrophenol following oral administration of parathion in the rabbit.
abstract: The urinary excretion kinetics of p-nitrophenol were studied in rabbits following oral administration of parathion at a dose of 3 mg/kg. Elimination of p-nitrophenol began rapidly, and of the total amount excreted during the study period, 46% was excreted in the first 3 h; 85% was excreted at 6 h after administration of the pesticide. The mean maximum excretion rate of p-nitrophenol was 111.15 +/- 61.02 micrograms/h reached in a time of 0.77 +/- 0.26 h. The formation and disappearance rate constants of the metabolite were 2.85 +/- 2.80 h-1 and 0.80 +/- 0.28 h-1, respectively. A linear relationship was observed between the plasma concentrations of parathion and the urinary excretion rate of p-nitrophenol.
authors.affiliation: Department of Food Science, Toxicology and Chemical Analysis, Faculty of Pharmacy, University of Salamanca, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Peña-Egido
authors.forename: E L
authors.initials: EL
authors.lastname: Mariño-Hernandez
authors.forename: C
authors.initials: C
authors.lastname: Santos-Buelga
authors.forename: J C
authors.initials: JC
authors.lastname: Rivas-Gonzalo
mesh_terms: D000284:Administration, Oral; D000818:Animals; D008297:Male; D009596:Nitrophenols / Q000652:urine*; D010278:Parathion / Q000493:pharmacokinetics* / Q000633:toxicity; D011817:Rabbits
chemical_list: D009596:Nitrophenols; D010278:Parathion; C024836:4-nitrophenol