title: Resolution of experimental microvascular vasoconstriction in rats by topical application of lidocaine hydrochloride in varying concentrations.
abstract: Various lidocaine hydrocholoride concentrations were used to measure the degree of resolution of ergotamine-induced vasospasm of the rat tail artery. Also further studies are indicated; 12% lidocaine seems to be as effective as 20% lidocaine. The widely used 2% lidocaine had little effect on the experimentally induced vasospasm.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Academic Hospital Dijkzigt, Rotterdam, the Netherlands.
authors.forename: W H
authors.initials: WH
authors.lastname: Beekman
authors.forename: J E
authors.initials: JE
authors.lastname: Sluimers
authors.forename: W J
authors.initials: WJ
authors.lastname: Kort
authors.forename: J C
authors.initials: JC
authors.lastname: van der Meulen
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004878:Ergotamine / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013623:Tail / Q000098:blood supply; D014661:Vasoconstriction / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D008012:Lidocaine; D004878:Ergotamine