An increase of collagen biosynthesis precedes other symptoms of ethanol-induced liver damage in rats.
Treatment of rats with 10% ethanol for 6 months induced a 3-4-fold increase of [3H]proline incorporation into liver collagen and enhanced the level of prolyl hydroxylase activity in liver and serum of intoxicated rats. Several diagnostic tests used to assess liver disease failed to demonstrate any symptom of liver damage. Therefore, increased collagen biosynthesis appears to precede other symptoms of liver damage induced by ethanol.
Pawlicka
E
E
Department of Biochemistry, Medical Academy, Bialystok, Poland.
Bańkowski
E
E
Chrostek
L
L
Szmitkowski
M
M
D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D008099:Liver / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003094:Collagen