[Bone marrow monosomy 7 in children].
Three new cases of monosomy 7 are described. Two children, before onset of overt leukemia, had a preleukemic state: one with thrombopathy and myelodysplastic syndrome, the other with a moderate splenomegaly and an absolute monocytosis. In these two cases the leukemia was chemoresistant. The last child had a subacute myelomonocytic syndrome (juvenile type of chronic myelogenous leukemia) without high fetal hemoglobin value. She died from cachexia. The poor prognosis of monosomy 7 is underlined and such a chromosome deletion should be searched in myeloproliferative syndrome with monocytosis.
Nelken
B
B
L'Unité d'Hématologie Oncologique, Hôpital Calmette, Lille.
Lai
J L
JL
Facon
T
T
Lambilliotte
A
A
Gaudier
B
B
D001772:Blood Cell Count; D001856:Bone Marrow Examination; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D007621:Karyotyping; D009000:Monocytes / Q000473:pathology; D009006:Monosomy; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000235:genetics*; D011289:Preleukemia / Q000150:complications / Q000235:genetics*; D011379:Prognosis
Monosomie 7 médullaire chez l'enfant.