Influence of functional groups on homologous antibody affinity of 11 alpha-hydroxyprogesterone derivatives. I. Synthesis and affinity evaluation.
Syntheses and cross-reactivities with progesterone toward the same specific antibody are reported for a series of amides of 11 alpha-hydroxyprogesterone 11-hemisuccinate. Some hypotheses are made regarding the effects of the chemical structure of the substituents on the immunological properties of derivatives.
Bacigalupo
M A
MA
C.N.R., Instituto di Chimica degli Ormoni, Milano, Italy.
Colombi
S
S
Saita
R
R
Parini
C
C
D000577:Amides / Q000138:chemical synthesis / Q000276:immunology*; D000915:Antibody Affinity; D000918:Antibody Specificity; D055598:Chemical Phenomena; D002621:Chemistry; D002845:Chromatography / Q000379:methods; D003429:Cross Reactions; D006908:Hydroxyprogesterones / Q000138:chemical synthesis / Q000276:immunology*; D011374:Progesterone / Q000031:analogs & derivatives* / Q000276:immunology; D011863:Radioimmunoassay; D013329:Structure-Activity Relationship
D000577:Amides; D006908:Hydroxyprogesterones; D011374:Progesterone; C030250:progesterone 11-hemisuccinate