title: Effect of 24R,25-dihydroxyvitamin D3 in experimental diabetic rats.
abstract: The results are presented of a controlled study in male Wistar rats into the effects of 24R,25-dihydroxyvitamin D3 on blood glucose levels, bone calcium content and ADP-induced platelet aggregation in streptozocin-induced diabetes mellitus. Blood glucose levels were shown to be decreased by 10 micrograms/kg 24R,25-dihydroxyvitamin D3. The reduced bone calcium content associated with diabetes mellitus was returned to normal levels with both 1 and 10 micrograms/kg 24R,25-dihydroxyvitamin D3. It was also shown to exhibit dose-dependent anti-platelet activity. The data suggest that 24R,25-dihydroxyvitamin D3 might have potential as a mild therapeutic agent in the treatment of osteoporosis and platelet hyperactivity associated with diabetes mellitus.
authors.affiliation: Biomedical Research Laboratories, Kureha Chemical Industry Co., Ltd, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Katoh
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: H
authors.initials: H
authors.lastname: Yamato
authors.forename: T
authors.initials: T
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Fujii
authors.forename: F
authors.initials: F
authors.lastname: Yoshino
authors.forename: T
authors.initials: T
authors.lastname: Kodaira
authors.forename: Y
authors.initials: Y
authors.lastname: Konai
mesh_terms: D015650:24,25-Dihydroxyvitamin D 3; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001791:Blood Platelet Disorders / Q000188:drug therapy; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy*; D004100:Dihydroxycholecalciferols / Q000494:pharmacology*; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001786:Blood Glucose; D004100:Dihydroxycholecalciferols; D015650:24,25-Dihydroxyvitamin D 3; D002118:Calcium