Sprouting of CGRP nerve fibers in response to dentin injury in rat molars.
Light and electron microscopic immunocytochemistry showed extensive increases in the number of calcitonin gene-related peptide immunoreactive (CGRP-IR) nerve fibers subjacent to injured root dentin of rat molars. Sprouting was greatest at 4 days and returned to normal 10-21 days post injury. Non-CGRP-IR fibers were also increased at 4 days. The results suggest that rapid reversible sprouting of sensory nerve fibers may be an integral part of tissue reactions to injury.
Taylor
P E
PE
Department of Endodontics, Dental School, University of Washington, Seattle 98195.
Byers
M R
MR
Redd
P E
PE
D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D003804:Dentin / Q000293:injuries* / Q000294:innervation / Q000648:ultrastructure; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D008963:Molar / Q000293:injuries*; D009475:Neurons, Afferent / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D009479:Neuropeptides / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide