Synthesis and pharmacological properties of new N-aminoalkyl-2-pyrrolidinone derivatives.
The paper describes the mode of obtaining and physico-chemical properties of new 1-(beta-hydroxy-gamma-aminopropyl)-2-pyrrolidinone derivatives and their antiarrhythmic effect and the action on the circulatory system.
Malawska
B
B
Department of Pharmaceutical Chemistry, Medical Academy, Kraków, Poland.
Gorczyca
M
M
Cebo
B
B
Krupińska
J
J
D000758:Anesthesia; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004562:Electrocardiography; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects; D013045:Species Specificity
D000889:Anti-Arrhythmia Agents; D011760:Pyrrolidinones