Clinical evaluation of subcutaneously administered DDAVP.
1-deamino-8D-arginine vasopressin was given subcutaneously at the dosage of 0.3 micrograms/Kg. b.w. to 24 mild factor VIII deficient patients (16 mild, 2 moderate hemophiliacs and 6 patients with von Willebrand's Disease), to treat bleedings (10 episodes) or to prevent bleeding during and after dental extractions (6 extractions) and surgery (11 interventions). None of the patients who underwent surgery bled. The vasopressin analogue was effective in the early treatment of muscle hematomas and promptly stopped all mucosal hemorrhages. Most of the patients treated for "spontaneous" bleedings performed self-injections at home. The drug was administered in two pharmaceutical forms (4 and 40 micrograms/ml): no differences in the clinical outcome were found. No significant side effects were recorded. The subcutaneous route of DDAVP administration thus seems to be particularly useful (mainly in the concentrated pharmaceutical form) in treating mild factor VIII deficiencies even on self- and home-treatment basis.
Ghirardini
A
A
Dipartimento di Biopathologia Umana, Università di Roma, La Sapienza, Italia.
Chistolini
A
A
Tirindelli
M C
MC
Di Paolantonio
T
T
Iacopino
G
G
Mariani
P
P
Chirletti
P
P
Agrestini
F
F
Mariani
G
G
D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000627:therapeutic use*; D006467:Hemophilia A / Q000150:complications*; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007279:Injections, Subcutaneous; D013514:Surgical Procedures, Operative / Q000009:adverse effects; D014081:Tooth Extraction / Q000009:adverse effects; D014842:von Willebrand Diseases / Q000150:complications*
D003894:Deamino Arginine Vasopressin