BN-52021 protects guinea-pig from heart anaphylaxis.
BN-52021 preserves "in vitro" the actively sensitized guinea-pig heart from the immunological reaction. This ginkgolide reduces mediator release (histamine, thromboxane-A2 and slow reacting substance of anaphylaxis) in a dose-dependent manner, particularly that of histamine. These results evidence either an important role for PAF in guinea pig anaphylaxis or a wider spectrum of activity for BN-52021.
Magni
F
F
Institute of Pharmacological Sciences, University of Milan, Italy.
Rossoni
G
G
Berti
F
F
D000707:Anaphylaxis / Q000517:prevention & control*; D000818:Animals; D004224:Diterpenes; D046934:Ginkgolides; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006632:Histamine / Q000378:metabolism; D007783:Lactones / Q000627:therapeutic use*; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D013929:Thromboxane B2 / Q000378:metabolism
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; D013929:Thromboxane B2; D006632:Histamine; C045856:ginkgolide B