[Effect of Polfos on bleeding time. I. Changes in the formed elements of the blood in rats exposed to Polfos].
The influence of Polfos and its metabolite, 2,4 dichlorophenacyl bromide, on the bleeding time, count of platelets, platelets aggregation, count of erythrocytes, level of haemoglobin and count of leucocytes in rats were studied. The data indicate that Polfos prolonged the bleeding time in the 2nd hour after its administration. A decrease of the platelets count was observed only in the initial phase of the intoxication. In the study the platelets count, red cells count, hematocrit and the level of haemoglobin increased 24 hours after the administration of the pesticide. The results demonstrate that the prolongation of the bleeding time in the rats after the administration of Polfos partly depends on the changing of the platelets count.
Konopelko
M
M
Akademia Medyczna w Białymstoku, Zakład Farmakodynamiki.
Malinowska
B
B
Chabielska
E
E
Buczko
W
W
D000818:Animals; D001772:Blood Cell Count; D002709:Chlorfenvinphos / Q000031:analogs & derivatives / Q000506:poisoning*; D004912:Erythrocytes / Q000187:drug effects* / Q000473:pathology; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007306:Insecticides / Q000506:poisoning*; D007962:Leukocytes / Q000187:drug effects* / Q000473:pathology; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D006454:Hemoglobins; D007306:Insecticides; D010975:Platelet Aggregation Inhibitors; C006037:methylbromfenvinphos; D002709:Chlorfenvinphos
Wpływ Polfosu na czas krawawienia. I. Zachowanie sie elementów morfotycznych krwi szczurów eksponowanych na Polfos.