title: Experimental increase in brain HIPDM uptake by hypercapnia.
abstract: The 30-min brain uptake of [125I]HIPDM was measured in conscious rats--normocapnic (n = 8), hypercapnic (n = 12), and hyperoxic (n = 6). A mean 41.2% higher uptake was found in the brains of hypercapnic animals (p less than 0.01). In the three groups of rats, brain HIPDM uptake had a negative correlation with body weight (p less than 0.001) and a positive correlation with arterial pCO2 (p less than 0.01), when adjusted for body weight. These results indicate that HIPDM uptake with hypercapnia may be used as a provocative test to measure cerebral blood flow reserves.
authors.affiliation: Department of Radiology, University of Miami School of Medicine, FL 33101.
authors.forename: N D
authors.initials: ND
authors.lastname: Karatzas
authors.forename: G N
authors.initials: GN
authors.lastname: Sfakianakis
authors.forename: D
authors.initials: D
authors.lastname: Pappas
authors.forename: R
authors.initials: R
authors.lastname: Duncan
authors.forename: A
authors.initials: A
authors.lastname: Heal
authors.forename: A
authors.initials: A
authors.lastname: Serafini
authors.forename: H F
authors.initials: HF
authors.lastname: Kung
mesh_terms: D000818:Animals; D001835:Body Weight; D001921:Brain / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D006935:Hypercapnia / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014055:Tomography, Emission-Computed
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C036739:N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine