title: Importance of early initiation of dietary protein restriction for the prevention of experimental progressive renal disease.
abstract: The effect of dietary protein restriction on the progress of renal dysfunction was investigated in rats with adriamycin (ADR)-induced progressive glomerular disease. Dietary protein was reduced from 20% (normal diet) to 5% (low protein) immediately after (ADR-0w), 8 weeks (ADR-8w) or 16 weeks (ADR-16w) after the repeated injection of ADR. In the unrestricted (ADR-UR) group rats were fed 20% of protein throughout the 24-week experiment. Massive urinary protein developed immediately after ADR injection and significantly decreased by reducing dietary protein in all the groups (ADR-0w, ADR-8w, ADR-16w). However, plasma protein and serum albumin were low irrespective of the improvement of urinary protein. BUN and serum creatinine were unchanged in ADR-0w and ADR-8w groups, while they were increased in ADR-16w and ADR-UR groups. Glomerular sclerosis and tubular atrophy were much less severe in ADR-0w and ADR-8w than in ADR-16w and ADR-UR groups. The results indicate that dietary protein restriction checks the further progress of renal dysfunction. The importance of the time when protein intake should be reduced is discussed.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Motomura
authors.forename: S
authors.initials: S
authors.lastname: Okuda
authors.forename: T
authors.initials: T
authors.lastname: Sanai
authors.forename: T
authors.initials: T
authors.lastname: Ando
authors.forename: K
authors.initials: K
authors.lastname: Onoyama
authors.forename: M
authors.initials: M
authors.lastname: Fujishima
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D004044:Dietary Proteins / Q000008:administration & dosage*; D004317:Doxorubicin; D005921:Glomerulonephritis / Q000139:chemically induced / Q000178:diet therapy* / Q000473:pathology; D008297:Male; D011507:Proteinuria / Q000652:urine; D051381:Rats; D011917:Rats, Inbred Lew; D012709:Serum Albumin / Q000032:analysis
chemical_list: D004044:Dietary Proteins; D012709:Serum Albumin; D004317:Doxorubicin; D002784:Cholesterol; D003404:Creatinine