Immunocytochemical localization of angiotensin-(1-7) in the rat forebrain.
Recent findings by this group have led us to reconsider the view that amino (N-) terminal fragments of angiotensin (Ang) II are inactive degradation products of renin-angiotensin system. To further examine this possibility, an antibody to Ang-(1-7), the N-terminal heptapeptide, was produced to demonstrate the neuroanatomical distribution of the rat brain. Ang-(1-7)-immunoreactivity was found in paraventricular, supraoptic, and suprachiasmatic nuclei, bed nucleus of the stria terminalis, substantia innominata, median eminence, and neurohypophysis. This distribution of Ang-(1-7) in the rat forebrain, together with our previous demonstrations of vasopressin secretion in response to this peptide, suggest that Ang-(1-7) functions as a neuromodulator.
Block
C H
CH
Research Institute of the Cleveland Clinic Foundation, OH 44195-5070.
Santos
R A
RA
Brosnihan
K B
KB
Ferrario
C M
CM
D000803:Angiotensin I; D000804:Angiotensin II / Q000032:analysis*; D000818:Animals; D001921:Brain / Q000166:cytology* / Q000187:drug effects; D001933:Brain Stem / Q000166:cytology; D003078:Colchicine / Q000494:pharmacology; D007150:Immunohistochemistry; D008297:Male; D009928:Organ Specificity; D010446:Peptide Fragments / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D010446:Peptide Fragments; D000804:Angiotensin II; D000803:Angiotensin I; C118790:angiotensin I (1-7); D003078:Colchicine