Group contributions to hydrophobicity and elution behaviour of pyridine derivatives in reversed-phase high-performance liquid chromatography.
The mean hydrophobic contributions, pi*m, of substituents in a sample of 34 monosubstituted pyridines has been determined by using reversed-phase high-performance liquid chromatography. The values are compared with those obtained for benzene.
Gago
F
F
Department of Pharmacology, University of Alcalá de Henares, Madrid, Spain.
Alvarez-Builla
J
J
Elguero
J
J
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D011725:Pyridines / Q000302:isolation & purification*; D013056:Spectrophotometry, Ultraviolet
D011725:Pyridines