Influence of gamma radiation on the gel rigidity index and binding capability of gelatin.
Changes in the rigidity indices of gelatin gel before and after gamma irradiation were characterized by dynamic mechanical testing, and the significance of these changes on the strength of granules was evaluated. Results illustrate the difficulty of obtaining reproducible values for gels containing less than 20% gelatin. However, rigidity indices for gels with a gelatin content of 20% and higher are consistent and may provide a useful controlling factor for preparation of gelatins of more precise specifications. The data indicate that rigidity degradation kinetics of several concentrations of gelatin gel at different radiation doses are complex, showing both increasing and decreasing rates. These findings strongly suggest that doses of less than 2.0 Mrad of gamma radiation should be used in order to obtain gelatins of acceptable quality for pharmaceutical applications. The crushing strength of granules of lactose powder granulated with irradiated gelatin reveals that the binding capability of such gelatin is significantly reduced. The results obtained for various size fractions and granule hardnesses containing different binder concentrations also suggest that particle size influences the granule strength to a lesser extent than does binder concentration and its consistency.
Fassihi
A R
AR
Department of Pharmacy, University of the Witwatersrand, Medical School, Parktown, Johannesburg, South Africa.
Parker
M S
MS
D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D005780:Gelatin / Q000528:radiation effects*; D005782:Gels / Q000528:radiation effects*; D006244:Hardness; D006245:Hardness Tests; D007785:Lactose; D008855:Microscopy, Electron, Scanning; D011208:Powders; D012212:Rheology; D013499:Surface Properties; D013607:Tablets
D003037:Cobalt Radioisotopes; D005782:Gels; D011208:Powders; D013607:Tablets; D005780:Gelatin; D007785:Lactose