title: Lack of effect of atenolol on the pharmacokinetics of theophylline.
abstract: The effects of 3 days of pretreatment with cardioselective doses of atenolol on theophylline pharmacokinetics were determined. Nine healthy nonsmoking male volunteers received 6 mg kg-1 i.v. aminophylline under baseline conditions and after both 50 mg day-1 and 100 mg day-1 atenolol. Theophylline clearance, volume of distribution and half-life were not influenced by atenolol pretreatment. These data indicate that cardioselective doses of atenolol do not alter the pharmacokinetics of theophylline.
authors.affiliation: Department of Pharmacy, State University of New York, Buffalo 14260.
authors.forename: L A
authors.initials: LA
authors.lastname: Cerasa
authors.forename: J S
authors.initials: JS
authors.lastname: Bertino
authors.forename: E A
authors.initials: EA
authors.lastname: Ludwig
authors.forename: M
authors.initials: M
authors.lastname: Savliwala
authors.forename: E
authors.initials: E
authors.lastname: Middleton
authors.forename: R L
authors.initials: RL
authors.lastname: Slaughter
mesh_terms: D000328:Adult; D001262:Atenolol / Q000494:pharmacology*; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D008297:Male; D013806:Theophylline / Q000493:pharmacokinetics*
chemical_list: D001262:Atenolol; D013806:Theophylline