Effect of human recombinant interleukin 5 and G-CSF on eosinophil colony formation.
Human recombinant (r) IL-5 was shown to have the activity to stimulate eosinophil (Eo) colony formation from human non-T, non-adherent bone marrow cells. The majority of these colonies were found to contain a small number of basophils, macrophages or neutrophils. Human rG-CSF, which alone did not stimulate Eo colony formation, showed an enhancing effect on Eo colony formation when added with IL-5. IL-5 seems to stimulate the proliferation and differentiation of CFU-Eo, while G-CSF acts on the early stage of eosinophilopoiesis.
Enokihara
H
H
Third Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
Nagashima
S
S
Noma
T
T
Kajitani
H
H
Hamaguchi
H
H
Saito
K
K
Furusawa
S
S
Shishido
H
H
Honjo
T
T
D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003114:Colony-Forming Units Assay; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D004804:Eosinophils / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D015848:Interleukin-5; D007378:Interleukins / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology
D003115:Colony-Stimulating Factors; D015848:Interleukin-5; D007378:Interleukins; D011994:Recombinant Proteins