title: Existence and coexistence of calcitonin gene-related peptide, vasoactive intestinal polypeptide- and somatostatin-like immunoreactivities in spinal cord motoneurons of developing embryos and post-hatch chicks.
abstract: By use of immunocytochemical methods, it is shown that immunoreactive calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP) and somatostatin (SOM) are present in motoneurons in the chicken spinal cord. While CGRP-like immunoreactivity (LI) is present in numerous motoneurons both before and after hatching, SOM- and VIP-LI markedly decline at the end of the embryonic period. Evidence is also provided for coexistence of some of these peptides in certain spinal motoneurons.
authors.affiliation: Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
authors.forename: M J
authors.initials: MJ
authors.lastname: Villar
authors.forename: M
authors.initials: M
authors.lastname: Huchet
authors.forename: T
authors.initials: T
authors.lastname: Hökfelt
authors.forename: J P
authors.initials: JP
authors.lastname: Changeux
authors.forename: J
authors.initials: J
authors.lastname: Fahrenkrug
authors.forename: J C
authors.initials: JC
authors.lastname: Brown
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D015740:Calcitonin Gene-Related Peptide; D002642:Chick Embryo; D002645:Chickens; D007150:Immunohistochemistry; D009046:Motor Neurons / Q000378:metabolism / Q000502:physiology*; D009479:Neuropeptides / Q000378:metabolism / Q000502:physiology*; D010455:Peptides / Q000378:metabolism / Q000502:physiology*; D013116:Spinal Cord / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism / Q000502:physiology*
chemical_list: D009479:Neuropeptides; D010455:Peptides; C029993:somatostatin-like peptides; D014660:Vasoactive Intestinal Peptide; D015740:Calcitonin Gene-Related Peptide