title: Alterations of acyl-neuraminic acids on T-lymphocytes in cases of melanoma.
abstract: Content and distribution of the different sialic acids on human lymphocytes, isolated from 7-10 ml of fresh human blood, were determined using microanalytical methods, such as HPLC and a colorimetric test. Comparison of the data of patients with melanoma with those of healthy persons shows an evident increase of the sialic acid content combined with a shift of the sialic acid distribution to higher O-acetylated derivatives.
authors.affiliation: Universität des Saarlandes, Biochemie.
authors.forename: R
authors.initials: R
authors.lastname: Holzhauser
authors.forename: H
authors.initials: H
authors.lastname: Faillard
authors.forename: W
authors.initials: W
authors.lastname: Klose
authors.forename: W
authors.initials: W
authors.lastname: Huber
authors.forename: H
authors.initials: H
authors.lastname: Stickl
authors.forename: M
authors.initials: M
authors.lastname: Landthaler
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003124:Colorimetry; D006801:Humans; D008545:Melanoma / Q000276:immunology*; D012794:Sialic Acids / Q000378:metabolism*; D012878:Skin Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D012794:Sialic Acids