Production of tumour necrosis factor and interleukin 1 by monocytes of patients with previous Yersinia arthritis.
We studied production of tumour necrosis factor (TNF) and interleukin 1 (IL-1) by using purified peripheral blood monocytes of patients with previous yersinia arthritis (YA) and of healthy HLA-B27 positive and negative controls. Lipopolysaccharide-exposed cells of HLA-B27 positive and negative patients, and those of HLA-B27 positive controls, generated significantly more TNF than did HLA-B27 negative control cells. There was a positive correlation between the levels of TNF and IL-1. Our results give credence to the view that augmented production of phlogistic mediators may contribute to inflammatory symptoms in patients with HLA-B27 associated disease.
Repo
H
H
Department of Bacteriology and Immunology, University of Helsinki, Finland.
Jäättelä
M
M
Leirisalo-Repo
M
M
Hurme
M
M
D000328:Adult; D001170:Arthritis, Infectious / Q000209:etiology / Q000276:immunology*; D005260:Female; D015235:HLA-B Antigens / Q000032:analysis; D015796:HLA-B27 Antigen; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007375:Interleukin-1 / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*; D015009:Yersinia Infections / Q000276:immunology*
D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D007375:Interleukin-1; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D007213:Indomethacin