X-ray structure determination of mexiprostil, a new gastroprotective 16-methoxy-16-methyl-PGE1 analogue.
Mexiprostil is a new gastroprotective 16-methoxy-16-methyl-PGE1 methyl ester. To assign the absolute configuration at C-15, a crystalline high-melting C-1 ester analog 5 11,15-dihydroxy-16-methoxy-16-methyl-9-oxoprost-13-en-1-oic acid 4-(4-bromobenzamide)phenyl ester (15R, 16R) was prepared and submitted to single crystal X-ray analysis. Since C-8, C-11, C-12 and C-16 are shown to have R configurations, the X-ray diffraction results established that the configuration at C-15 is also R.
Pelizzi
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Department of Diffractometry, CNR, University of Parma, Italy.
Ciabatti
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R
Padova
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Tarzia
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G
D000527:Alprostadil / Q000031:analogs & derivatives*; D000897:Anti-Ulcer Agents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D011459:Prostaglandins E, Synthetic; D014961:X-Ray Diffraction
D000897:Anti-Ulcer Agents; D011459:Prostaglandins E, Synthetic; D000527:Alprostadil; C036058:mexiprostil