title: Effects of interleukin-2 on oxygen delivery and consumption in patients with advanced malignancy.
abstract: We evaluated the effects of fluid challenges on oxygen delivery (DO2) and oxygen consumption (VO2) in nine patients receiving immunotherapy with interleukin-2. Fluid resuscitation produced an increase in DO2 from 15.7 +/- 3.1 to 17.4 +/- 3.5 ml/min/kg (mean +/- SD, p less than 0.001), which was associated with a corresponding increase in VO2, from 2.8 +/- 0.7 to 3.1 +/- 0.6 ml/min/kg (p less than 0.01). These results suggest that oxygen consumption may be dependent on oxygen delivery in patients on IL-2 therapy. The presence of oxygen supply dependency may contribute to the multiple organ failure observed with IL-2 administration.
authors.affiliation: Department of Medicine, University of Maryland Medical System, Baltimore.
authors.forename: H J
authors.initials: HJ
authors.lastname: Silverman
authors.forename: J
authors.initials: J
authors.lastname: Abrams
authors.forename: L J
authors.initials: LJ
authors.lastname: Rubin
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002496:Central Venous Pressure; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011669:Pulmonary Wedge Pressure; D014655:Vascular Resistance
chemical_list: D007376:Interleukin-2; D010100:Oxygen