Phosphatidylserine activity on prolactin brain receptors of aged rabbits.
1. PRL receptors in the hypothalamus and substantia nigra of aged rabbits (28-month-old) are significantly reduced in comparison with young rabbits (6-month-old). 2. Repeated treatments with BC-PS are able to gradually increase the PRL receptor number both in hypothalamus and nigra. However only after 30 days of treatment the binding reaches the mean values observed in young rabbits. 3. Aged rabbits showed an evident increase in PRL plasma levels in comparison with young animals. In BC-PS treated animals this increase was not more apparent. Moreover in young rabbits treated with BC-PS an evident decrease in basal PRL plasma levels was observed.
Di Carlo
R
R
Department of Experimental Pharmacology, University of Naples, Italy.
Muccioli
G
G
Ghe'
C
C
Bellussi
G
G
Ravetti
D
D
Genazzani
E
E
D000311:Adrenal Glands / Q000254:growth & development; D000375:Aging; D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D002831:Choroid Plexus / Q000254:growth & development; D005260:Female; D007700:Kinetics; D008081:Liposomes; D008099:Liver / Q000254:growth & development; D008297:Male; D009928:Organ Specificity; D010718:Phosphatidylserines / Q000494:pharmacology*; D011388:Prolactin / Q000378:metabolism; D011817:Rabbits; D011981:Receptors, Prolactin / Q000187:drug effects / Q000378:metabolism*
D008081:Liposomes; D010718:Phosphatidylserines; D011981:Receptors, Prolactin; D011388:Prolactin