title: Protective efficacy of plasma-derived hepatitis beta vaccine in preventing perinatal transmission of HBV infection in infants of HBsAg/HBeAg positive mothers.
abstract: Two hundred and four newborn infants of HBsAg/HBeAg carrier mothers were randomly assigned into three groups. Group A (69 infants) received full-dose HB vaccine, group B (70 infants) received half-dose HB vaccine at birth, 1 month, 3 months and group C (65 infants) were untreated control group. After twelve months follow-up the cumulative incidence of HBs antigenemia was 17.2%, 30% in group A, B respectively as compared with 78.4% in group C (p less than 0.001). The protective efficacy rates (PER) of group A and B were 78.1% and 61.7% respectively (p less than 0.05). The vaccine was also effective in preventing persistent HBsAg carriers (HBsAg positive for at least 6 months). The PER of group A and B were at least 74.9% and 49.2% respectively (p less than 0.001) at 1 year follow-up. From the practical point of view and economic reasons administration of full-dose HB vaccine give better protection to high risk infants.
authors.affiliation: Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
authors.forename: B
authors.initials: B
authors.lastname: Pojanagaroon
authors.forename: S
authors.initials: S
authors.lastname: Boonmar
authors.forename: K
authors.initials: K
authors.lastname: Chatiyanonda
authors.forename: S
authors.initials: S
authors.lastname: Nimmannitya
authors.forename: Y
authors.initials: Y
authors.lastname: Thanasophon
authors.forename: S
authors.initials: S
authors.lastname: Suksangium
authors.forename: V
authors.initials: V
authors.lastname: Sirivasin
authors.forename: C
authors.initials: C
authors.lastname: Chantrachaya
authors.forename: K
authors.initials: K
authors.lastname: Mizuno
mesh_terms: D002353:Carrier State / Q000635:transmission*; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009035:Mothers; D013785:Thailand; D014761:Viral Hepatitis Vaccines / Q000627:therapeutic use*
chemical_list: D014761:Viral Hepatitis Vaccines