A pharmacological dose of glucagon suppresses gastric emptying of a radiolabelled solid meal in humans.
The effect of glucagon (143 nmol i.v. bolus followed by 430 nmol infused at a constant rate over 90 min) vs placebo (normal saline) on gastric emptying was examined in a blind randomized study in eight healthy males. The gastric emptying of a radiolabelled solid meal was measured with the use of a gamma camera. Glucagon elicited a pronounced delay in gastric emptying in all subjects examined--mean gastric transit time MTT90 glucagon 44.2 +/- 0.22 min vs placebo 38.6 +/- 0.74 min, p less than 0.001.
Jonderko
G
G
Fourth Department of Internal Diseases, Silesian School of Medicine, Poland.
Gołab
T
T
Jonderko
K
K
D000328:Adult; D005746:Gastric Emptying / Q000187:drug effects*; D005934:Glucagon / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D011897:Random Allocation
D005934:Glucagon