title: Persistent alanine aminotransferase elevation in healthy Swedish blood donors--mainly caused by obesity.
abstract: Five hundred consecutive healthy blood donors were tested for serum alanine aminotransferase (ALT) and 44 (8.8%) had increased levels. Donors with and without raised ALT were compared in several aspects but only weight (expressed as percentage of ideal body weight) and sex differed significantly (119.1 +/- 14.5 and 106.3 +/- 12.8%, respectively; p less than 0.001 and males 97.7 and 77.1%, respectively; p less than 0.01). The 44 donors with raised ALT were followed up and in 13 out of 15 donors with persistently raised ALT without obvious reason, a liver biopsy was performed. Ten donors had various degrees of liver steatosis, 2 had normal liver morphology and in 1 donor chronic hepatitis could not be ruled out. If ALT screening is introduced as a surrogate test for non-A, non-B hepatitis in Swedish blood donors, we suggest that a correction for overweight must be considered in order to minimize donor loss.
authors.affiliation: Department of Infectious Diseases, Ostra Hospital, Göteborg, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Wejstål
authors.forename: G
authors.initials: G
authors.lastname: Hansson
authors.forename: A
authors.initials: A
authors.lastname: Lindholm
authors.forename: G
authors.initials: G
authors.lastname: Norkrans
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D001782:Blood Donors; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000201:enzymology*; D013548:Sweden
chemical_list: D000410:Alanine Transaminase