title: Effect of propofol on cerebral blood flow and metabolism in man.
abstract: Cerebral blood flow, cerebral oxygen consumption, lactate and glucose metabolism were measured in 13 patients during anaesthesia with nitrous oxide, oxygen and enflurane 0.5% and after 30 minutes infusion of propofol. The mean blood concentration of propofol was 4.06 micrograms/ml. Cerebral blood flow decreased by 27.6% and cerebral vascular resistance by 51%. There were no changes in lactate and glucose metabolism. Cerebral oxygen consumption decreased by 18.25%. Changes in the electro-encephalograph were related to the blood levels of propofol.
authors.affiliation: Department of Isotopes, Erasme Hospital, Free University of Brussels, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Vandesteene
authors.forename: V
authors.initials: V
authors.lastname: Trempont
authors.forename: E
authors.initials: E
authors.lastname: Engelman
authors.forename: T
authors.initials: T
authors.lastname: Deloof
authors.forename: M
authors.initials: M
authors.lastname: Focroul
authors.forename: A
authors.initials: A
authors.lastname: Schoutens
authors.forename: M
authors.initials: M
authors.lastname: de Rood
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D000777:Anesthetics / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D010636:Phenols / Q000494:pharmacology*; D015742:Propofol; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D000777:Anesthetics; D010636:Phenols; D015742:Propofol