Nephrotoxicity associated with ifosfamide.
Three patients developed a Fanconi syndrome with impairment of glomerular function (endogenous creatinine clearance 30-60 ml/min per 1.73 m2) during and/or after treatment with ifosfamide according to the SIOP-MMT 84 protocol in which ifosfamide was given in a dose of 3000 mg/m2 every 4 weeks over a 10-month period. The need for early substitution therapy in patients with the Fanconi syndrome is stressed. The renal lesions in our patients were irreversible.
Smeitink
J
J
Department of Paediatrics, University Hospital, Nijmegen, The Netherlands.
Verreussel
M
M
Schröder
C
C
Lippens
R
R
D000293:Adolescent; D002675:Child, Preschool; D005198:Fanconi Syndrome / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects*
D007069:Ifosfamide