Effects of bepridil on calcium release from rat heart mitochondria.
Bepridil at concentrations above 10 microM, and at pH 7.2 stimulates calcium release from rat heart mitochondria. However this action is different from that of ClCCP, an uncoupler of oxidative phosphorylations, since it is ruthenium red insensitive. At lower concentrations bepridil may inhibit the Na-induced calcium release. The effects of bepridil depend on the pH and indicate that the protonated form of the drug is more efficient on calcium release than the basic form.
Schneider
J M
JM
Inserm U 195, Laboratoire de Pharmacologie Médicale, Faculté de Médecine, Clermont-Ferrand, France.
Berson
G
G
Cruz
C
C
Younes
A
A
D000818:Animals; D015764:Bepridil; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D012964:Sodium / Q000502:physiology
D002121:Calcium Channel Blockers; D011759:Pyrrolidines; D015764:Bepridil; D012964:Sodium; D002118:Calcium