title: Ro/SSA antigen in human epidermis.
abstract: It has been shown previously by an immunofluorescence technique, that whole serum from patients who have anti-Ro/SSA autoantibodies reacts with a component or components of the epidermis. We have now demonstrated by immunoblotting that the antigen identified in human epidermis by anti-Ro/SSA sera is Ro/SSA antigen, and that Ro/SSA antigen is present both in adult and in neonatal epidermis. The presence of this antigen in tissues which are injured in the anti-Ro/SSA-associated syndromes subacute cutaneous lupus erythematosus and neonatal lupus erythematosus supports the hypothesis that anti-Ro/SSA antibodies react with Ro/SSA antigen in the skin and are important in the initiation of tissue damage.
authors.affiliation: Department of Dermatology, University of Colorado School of Medicine, Denver 80262.
authors.forename: S K
authors.initials: SK
authors.lastname: Jones
authors.forename: S
authors.initials: S
authors.lastname: Coulter
authors.forename: C
authors.initials: C
authors.lastname: Harmon
authors.forename: D A
authors.initials: DA
authors.lastname: Norris
authors.forename: M
authors.initials: M
authors.lastname: Rosandich
authors.forename: L A
authors.initials: LA
authors.lastname: Lee
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000276:immunology; D001324:Autoantigens / Q000032:analysis*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007231:Infant, Newborn; D008178:Lupus Erythematosus, Cutaneous / Q000276:immunology; D008179:Lupus Erythematosus, Discoid / Q000276:immunology; D008970:Molecular Weight; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D012867:Skin / Q000276:immunology*; D000099207:SS-A Antigen
chemical_list: D000974:Antibodies, Antinuclear; D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human; C035356:SS-A antibodies