[Synovial level of interleukin 1 and C3a in chronic polyarthritis, psoriatic arthritis and activated arthritis].
Concentrations of interleukin-1 (IL-1), C3a des Arg and immune complexes (IC) were investigated in knee effusions of patients with rheumatoid arthritis (RA; n = 36), psoriatic arthritis (Ps.A., n = 19) and osteoarthritis (n = 7). Maximal concentrations of IC and C3a des Arg were found in RA patients, high IL-1-activities could be demonstrated in patients with Ps.A. and seropositive RA. We found significant correlations between IL-1 and C3a des Arg, IL-1 and IC and C3a des Arg, and IC in Ps.A. patients, but not in RA or osteoarthritis patients. The role of IL-1 in the chronic inflammatory response and joint destruction in inflammatory joint diseases is discussed.
Hermann
E
E
Rheumatologische Universitätsklinik, Felix Platter-Spital, Basel.
Vogt
P
P
Hagmann
W
W
Dunky
A
A
Müller
W
W
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000936:Antigen-Antibody Complex / Q000378:metabolism; D001168:Arthritis / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D003166:Complement Activating Enzymes / Q000378:metabolism; D003172:Complement C1 / Q000378:metabolism; D015922:Complement C1q; D003176:Complement C3 / Q000031:analogs & derivatives / Q000378:metabolism*; D015926:Complement C3a; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000276:immunology*; D011565:Psoriasis / Q000276:immunology*; D013582:Synovial Fluid / Q000276:immunology*
D000936:Antigen-Antibody Complex; D003172:Complement C1; D003176:Complement C3; D007375:Interleukin-1; C044541:complement C3a, des-Arg-(77)-; D015922:Complement C1q; D015926:Complement C3a; D003166:Complement Activating Enzymes
Synoviaspiegel von Interleukin-1 und C3a bei chronischer Polyarthritis, Psoriasisarthritis und aktivierter Arthrose.