Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-beta.
Transforming growth factor-beta (TGF-beta) inhibits proliferation of Nb2 cells, a rat T lymphoma, in response to lactogens and interleukin-2. Prostaglandins may play an important role in the pathway through which TGF-beta exerts its inhibitory actions, because prostaglandin E2 also inhibits proliferation of Nb2 cells, and indomethacin, an inhibitor of prostaglandin synthesis, reverses the inhibitory effects of TGF-beta on Nb2 cell proliferation.
Rayhel
E J
EJ
Department of Life Sciences, Indiana State University, Terre Haute.
Prentice
D A
DA
Tabor
P S
PS
Flurkey
W H
WH
Geib
R W
RW
Laherty
R F
RF
Schnitzer
S B
SB
Chen
R
R
Hughes
J P
JP
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D015232:Dinoprostone; D013006:Growth Hormone / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology; D008223:Lymphoma / Q000473:pathology*; D010455:Peptides / Q000494:pharmacology*; D011388:Prolactin / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D013601:T-Lymphocytes / Q000187:drug effects; D015291:Transforming Growth Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects
D007376:Interleukin-2; D010455:Peptides; D011453:Prostaglandins; D011458:Prostaglandins E; D015291:Transforming Growth Factors; D011388:Prolactin; D013006:Growth Hormone; D015232:Dinoprostone; D007213:Indomethacin