title: Phenobarbital adsorption from simulated intestinal fluid, U.S.P., and simulated gastric fluid, U.S.P., by two activated charcoals.
abstract: Adsorption of phenobarbital from simulated intestinal and gastric fluids by two activated charcoals was studied. Adsorption isotherm data were analyzed by the linearized Langmuir equation and by nonlinear least-squares regression employing both Langmuir and Freundlich models. These analyses indicated differences in the capacities of the two charcoals for phenobarbital which could not be completely explained by surface-area considerations.
authors.affiliation: College of Pharmacy, University of Iowa, Iowa City 52242.
authors.forename: D E
authors.initials: DE
authors.lastname: Wurster
authors.forename: G M
authors.initials: GM
authors.lastname: Burke
authors.forename: M J
authors.initials: MJ
authors.lastname: Berg
authors.forename: P
authors.initials: P
authors.lastname: Veng-Pedersen
authors.forename: D D
authors.initials: DD
authors.lastname: Schottelius
mesh_terms: D000327:Adsorption; D002606:Charcoal; D005750:Gastric Juice / Q000378:metabolism*; D007419:Intestinal Secretions / Q000378:metabolism*; D010634:Phenobarbital / Q000493:pharmacokinetics*
chemical_list: D002606:Charcoal; D010634:Phenobarbital