Further studies on the role of the adrenals in the capsaicin-sensitive "gastric defence mechanism".
Adrenalectomy enhances the degree of gastric ulcers induced in rats by indomethacin or acetylsalicylic acid (ASA), but not that induced by 96% ethanol. Systemic capsaicin pretreatment, which selectively induces degeneration of primary sensory neurons, produces aggravation of gastric ulcers induced by ASA, indomethacin or 96% ethanol in sham-operated animals but not in adrenalectomized rats. These findings provide evidence for the involvement of adrenal glands in the capsaicin-sensitive "gastric defence mechanism" regardless of the ulcerogenic stimulus used.
Evangelista
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S
Pharmacology Dept., Menarini Pharm., Florence, Italy.
Maggi
C A
CA
Giuliani
S
S
Meli
A
A
D000311:Adrenal Glands / Q000502:physiology*; D000818:Animals; D001241:Aspirin / Q000633:toxicity; D002211:Capsaicin / Q000633:toxicity*; D004357:Drug Synergism; D000431:Ethanol / Q000633:toxicity; D007213:Indomethacin / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000503:physiopathology
D000431:Ethanol; D001241:Aspirin; D002211:Capsaicin; D007213:Indomethacin