Ocular distribution studies of the topical carbonic anhydrase inhibitors L-643,799 and L-650,719 and related alkyl prodrugs.
The ocular distribution of the carbonic anhydrase inhibitors 6-hydroxybenzothiazide-2-sulphonamide (L-643,799) and 6-hydroxybenzothiophene-2-sulphonamide (L-650,719) has been investigated in albino rabbits after conjunctival administration of these compounds or related alkyl prodrugs. The ocular penetration of L-650,719 has been compared in ocular normotensive rabbits and in animals whose intraocular pressure has been experimentally elevated.
Grove
J
J
Centre de Recherche, Merck Sharp & Dohme-Chibret, Riom, France.
Gautheron
P
P
Plazonnet
B
B
Sugrue
M F
MF
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D002257:Carbonic Anhydrase Inhibitors / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D002924:Ciliary Body / Q000378:metabolism; D003228:Conjunctiva / Q000378:metabolism; D003315:Cornea / Q000378:metabolism; D005016:Ethoxzolamide / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D005123:Eye / Q000378:metabolism*; D007498:Iris / Q000378:metabolism; D011355:Prodrugs / Q000494:pharmacology*; D011817:Rabbits; D013666:Tears / Q000378:metabolism; D013844:Thiazoles / Q000493:pharmacokinetics*; D013876:Thiophenes / Q000493:pharmacokinetics*
D002257:Carbonic Anhydrase Inhibitors; D011355:Prodrugs; D013844:Thiazoles; D013876:Thiophenes; C059454:6-hydroxybenzothiazide-2-sulfonamide; C054723:L 650719; D005016:Ethoxzolamide