title: Hachimijiogan produces testosterone in adult rat testes.
abstract: The effect of Hachimijiogan (HZ) and Keishibukuryogan (KB) on the steroid production in rats was examined in vivo and in vitro. In an in vivo study, HZ stimulated the testes from ten-week old male rats to produce testosterone, whereas KB decreased the tissue testosterone concentrations. The delta 4-androstenedione and estradiol-17 beta (E2) showed no significant changes. In an incubation study, HZ also stimulated the testosterone production. The data suggested that HZ produces testosterone in rat testes. The role of KB is questionable.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tsukuba, Ibaraki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Usuki
mesh_terms: D000735:Androstenedione / Q000096:biosynthesis; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004958:Estradiol / Q000096:biosynthesis; D066298:In Vitro Techniques; D008297:Male; D008518:Medicine, East Asian Traditional; D010946:Plants, Medicinal; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D013739:Testosterone / Q000096:biosynthesis*
chemical_list: D004365:Drugs, Chinese Herbal; C054591:hachimijiogan; C054593:keishibukuryogan; D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol