Association of complement allotype C4B2 with anterior uveitis.
We have studied allotypes of the fourth component of complement (C4) in 44 patients with inflammatory eye disease in order to define genetic susceptibility factors further. Twenty-six patients had uveitis (18 had anterior uveitis) and 18 patients had retinal vasculitis. There was an increased incidence of the C4B2 allotype in patients with anterior uveitis (pc less than 0.002), especially in HLA B27 positive males. In contrast, there was no increased incidence of specific allotypes in patients with posterior uveitis or retinal vasculitis. This genetic association may form part of a disease susceptibility supratype in patients with anterior uveitis.
Wakefield
D
D
Laboratory of Ocular Immunology, School of Pathology, University of New South Wales, Australia.
Buckley
R
R
Golding
J
J
McCluskey
P
P
Abi-Hanna
D
D
Charlesworth
J
J
Pussell
B
B
D000483:Alleles; D003181:Complement C4 / Q000235:genetics*; D015935:Complement C4b; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D012164:Retinal Diseases / Q000235:genetics / Q000276:immunology; D014605:Uveitis / Q000235:genetics / Q000276:immunology; D014606:Uveitis, Anterior / Q000235:genetics / Q000276:immunology*; D014657:Vasculitis / Q000235:genetics / Q000276:immunology
D003181:Complement C4; D005819:Genetic Markers; D015935:Complement C4b