title: Pneumocystis carinii serologic study in pediatric acquired immunodeficiency syndrome.
abstract: Pneumocystis carinii antigen and IgG antibody profiles were prepared on 17 pediatric patients with acquired immunodeficiency syndrome (AIDS) with pneumonia who were examined by a variety of invasive methods for P carinii organisms. Overall, the accuracy of the antigen assay in invasively examined pediatric patients with AIDS with pneumonia was 94% (sensitivity, 100%; specificity, 90%), as antigen and invasive test results agreed in 16 of 17 patients. No statistically significant differences in IgG titer were observed between controls and patients invasively examined for P carinii, whether the organism was observed in the specimen or not. Since 38% of all serum samples referred were derived from "blood-borne" cases of AIDS, including patients who contracted AIDS as a result of both transfusion and hemophilia A, this suggests that P carinii pneumonia or P carinii pneumonia- like pneumonias may be more common in these individuals.
authors.affiliation: Department of Pediatrics, University of Tennessee, Memphis 38163.
authors.forename: L L
authors.initials: LL
authors.lastname: Pifer
authors.forename: D R
authors.initials: DR
authors.lastname: Woods
authors.forename: C C
authors.initials: CC
authors.lastname: Edwards
authors.forename: R E
authors.initials: RE
authors.lastname: Joyner
authors.forename: F J
authors.initials: FJ
authors.lastname: Anderson
authors.forename: K
authors.initials: K
authors.lastname: Arheart
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis*; D000953:Antigens, Protozoan / Q000032:analysis*; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007841:Latex Fixation Tests; D008297:Male; D011010:Pneumocystis / Q000276:immunology*; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis* / Q000209:etiology
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D007074:Immunoglobulin G