title: Delayed hypometabolism induced by bilateral ischemia in the gerbil: regional metabolic thresholds.
abstract: The common carotid arteries were occluded in gerbils for 5 min and the metabolic rate was estimated by measuring the loss of high-energy phosphate equivalents at 4 days of reperfusion in the cerebral cortex, hippocampus, and striatum. Metabolites values at 4 days of reperfusion were not different from those of controls with the exception of glycogen, which was significantly elevated in the hippocampus. The metabolic rate, as determined by the "closed-box" method at 4 days of reflow, was decreased by more than 50% in all three regions after 5 min of bilateral ischemia. The ischemic time necessary to elicit the hypometabolic response at 4 days of reflow was 2, 3 and 4 min for the striatum, hippocampus, and cortex, respectively. It is suggested that delayed postischemic hypometabolism may be a component of an adaptive process which counteracts, to varying degrees, the deleterious effects of ischemia depending on the region examined.
authors.affiliation: Institute of Biochemistry, School of Medicine, Belgrade, Yugoslavia.
authors.forename: B B
authors.initials: BB
authors.lastname: Mrsulja
authors.forename: Y
authors.initials: Y
authors.lastname: Ueki
authors.forename: W D
authors.initials: WD
authors.lastname: Lust
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism* / Q000503:physiopathology; D003342:Corpus Striatum / Q000378:metabolism* / Q000503:physiopathology; D004734:Energy Metabolism; D005849:Gerbillinae; D005947:Glucose / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism* / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D008297:Male
chemical_list: D000255:Adenosine Triphosphate; D005947:Glucose