title: [Non-invasive Doppler sonographic measurement of left ventricular end-diastolic pressure].
abstract: The purpose of this study was to measure left-ventricular end-diastolic pressure (LVEDP) noninvasively by pulsed Doppler ultrasound. In 30 consecutive patients of mean age 57.4 +/- 10.2 years (range 32 to 72 years) undergoing left-heart catheterization for exclusively diagnostic reasons LVEDP (range 5 to 33 mm Hg, mean 14.8 +/- 0.61 mm Hg) was measured invasively. Immediately before cardiac catheterization the flow profile along the mitral valve was derived by pulsed Doppler ultrasound. The typical flow profiles characterizing the early diastolic passive (e-wave) and late diastolic active by atrial contraction caused inflow (l-wave) into the left ventricle and represented the indexes of left ventricular diastolic function. The ratio of the velocity-time-integrals in early (e) and late diastole (l) corresponds to the ratio of blood flow along the mitral valve in early and late diastole. It could be shown that there is a highly significant linear correlation (r = 0.98, p less than 0.001) between the ratio of the velocity-time-integrals of late to early diastole (l/e-ratio) and LVEDP. LVEDP can be calculated by means of the l/e-ratio according to the formula: LVEDP (in mm Hg) = 15.15 X l/e-ratio + 1.06 With increasing LVEDP the proportional share of the active mitral blood flow in the diastole increased; the share of the early diastolic passive blood flow decreased proportionally. In patients with a l/e-ratio greater than 1.2 LVEDP, was always greater than 18.5 mm Hg; in patients with l/e-ratio greater than 0.9, LVEDP did not exceed 15 mm Hg.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Universitäts-Klinikum Rudolf Virchow - Wedding - der FU Berlin.
authors.forename: T
authors.initials: T
authors.lastname: Störk
authors.forename: G
authors.initials: G
authors.lastname: Piske
authors.forename: C
authors.initials: C
authors.lastname: Ewert
authors.forename: R
authors.initials: R
authors.lastname: Müller
authors.forename: H
authors.initials: H
authors.lastname: Hochrein
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001783:Blood Flow Velocity; D001794:Blood Pressure; D006328:Cardiac Catheterization; D002302:Cardiac Output; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology*; D003327:Coronary Disease / Q000503:physiopathology*; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000503:physiopathology*
vernacular_title: Nichtinvasive dopplersonographische Messung des linksventrikulären enddiastolischen Druckes (LVEDP).