[Activation of the kallikrein-kinin system by intravenous administration of ionic and non-ionic radiographic contrast media].
Conventional ionic contrast media (sodium meglumine and amidotrizoate) were injected intravenously in 22 patients (group A); the nonionic, low-osmolar contrast medium iohexol was similarly administered to 24 patients (group B). This resulted in a significant (group A: P less than 0.05; group B: P less than 0.01) reduction in prekallikrein (93 and 94%, respectively), inhibition of kallikrein (90 and 88%), beta-factor XIIa inhibition (86 and 85%), and C1 inhibition (90 and 91%). Factor XII levels remained unchanged in both groups. These results indicate that the kallikrein-kinin system is activated even during routine, complication-free radiographic procedures involving contrast-media injection. There was no difference between ionic and nonionic contrast media.
Hoffmeister
H M
HM
Medizinische Klinik, Abteilung III, Universität Tübingen.
Fuhrer
G
G
Abels
G A
GA
Pirschel
J
J
Heller
W
W
D003174:Complement C1 Inactivator Proteins; D003287:Contrast Media / Q000494:pharmacology*; D003973:Diatrizoate / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D005174:Factor XII / Q000032:analysis / Q000037:antagonists & inhibitors*; D015956:Factor XIIa; D005260:Female; D006801:Humans; D007472:Iohexol / Q000494:pharmacology*; D007610:Kallikreins / Q000037:antagonists & inhibitors* / Q000097:blood*; D008297:Male; D011288:Prekallikrein / Q000097:blood*; D015842:Serine Proteinase Inhibitors
D003174:Complement C1 Inactivator Proteins; D003287:Contrast Media; D004338:Drug Combinations; D015842:Serine Proteinase Inhibitors; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D007472:Iohexol; C027278:urovision; D005174:Factor XII; D011288:Prekallikrein; D007610:Kallikreins; D015956:Factor XIIa
Aktivierung des Kallikrein-Kinin-Systems durch intravenöse Gabe von ionischen und nicht-ionischen Röntgenkontrastmitteln.