title: Kallikrein genes: cloning in man and expression in rat renal hypertension.
abstract: Genes for the small human glandular kallikrein gene family were isolated. Members of this family include renal/pancreatic kallikrein, prostate-specific antigen and a kallikrein encoded by the first gene that was isolated and completely sequenced, hGK-1. All share strong nucleotide sequence homology, although hGK-1 and the prostate-specific antigen gene are more closely related (86% identity in coding nucleotides). Renal/pancreatic kallikrein has 77% nucleotide homology to prostate-specific antigen, but only 60% amino acid homology. There is strong homology in the 5'-flanking DNA with mouse kallikrein genes, suggesting common regulatory mechanisms. In the rat one-kidney, one clip model of hypertension, renal kallikrein messenger (m)RNA increased during the initial transient rise in plasma renin, and then decreased.
authors.affiliation: Department of Physiology, University of Sydney, New South Wales, Australia.
authors.forename: L J
authors.initials: LJ
authors.lastname: Schedlich
authors.forename: D F
authors.initials: DF
authors.lastname: Catanzaro
authors.forename: B J
authors.initials: BJ
authors.lastname: Morris
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D006978:Hypertension, Renovascular / Q000235:genetics*; D007610:Kallikreins / Q000235:genetics*; D007668:Kidney / Q000503:physiopathology; D008969:Molecular Sequence Data; D051381:Rats; D015183:Restriction Mapping
chemical_list: D007610:Kallikreins