Effects of flunarizine on postischemic blood flow, energy metabolism and neuronal damage in the rat brain.
The effects of flunarizine on local cerebral blood flow, cortical energy metabolism and neuronal necrosis were evaluated in a rat model of forebrain ischemia. The application of flunarizine (2 X 40 mg/kg p.o.) at 24 and 4 h before ischemia accelerated the restoration of cortical high-energy phosphates during early post-ischemic recirculation and also increased the flow in cortical but not in hippocampal areas. Neuronal necrosis was reduced in the hippocampal CA 1 sector but unchanged in the cortex. It is concluded that flunarizine reduces ischemic damage mainly via a direct effect on brain tissue.
Beck
T
T
Institut für Pharmakologie und Toxikologie, Philipps-Universität, Marburg, F.R.G.
Nuglisch
J
J
Sauer
D
D
Bielenberg
G W
GW
Mennel
H D
HD
Rossberg
C
C
Krieglstein
J
J
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D005444:Flunarizine / Q000494:pharmacology*; D006624:Hippocampus / Q000098:blood supply / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D010710:Phosphates / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
D010710:Phosphates; D005444:Flunarizine