Experimental carbon tetrachloride-induced cirrhosis of the liver.
The authors produced an experimental model of cirrhosis by administering carbon tetrachloride (CCl4) intraperitoneally over 46 weeks to female Wistar rats at a dose of 0.2 ml of a solution of CCl4 in 33% mineral oil. The cytotoxic effect on the liver of this substance was evaluated in different developmental stages of the process by macroscopic, microscopic and ultrastructural studies.
Muñoz Torres
E
E
Department of Pathology, School of Medicine, University of Salamanca, Spain.
Paz Bouza
J I
JI
Abad Hernandez
M M
MM
Alonso Martin
M J
MJ
Lopez Bravo
A
A
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000166:cytology / Q000473:pathology / Q000648:ultrastructure; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains
D002251:Carbon Tetrachloride