title: Coagulation-fibrinolytic and kinin-forming systems in toxemia of pregnancy.
abstract: The relationship between the hemostatic system and the severity of toxemia was studied in 78 pregnant women with toxemia. The activities of plasma antithrombin III (AT-III), prekallikrein, plasminogen, alpha 2-plasmin inhibitor and factor XIII were determined using the chromogenic substrate and fluorescent methods. The antigens of both AT-III and factor XIII were determined by the single radial immunodiffusion method. Plasma bradykinin was determined by radioimmunoassay. The main results obtained were as follows. Both activities of AT-III and plasma prekallikrein decreased as the gestosis index increased (p less than 0.001), and a significant negative correlation was observed between the total score of the gestosis index and AT-III (r = -0.447, p less than 0.005) or plasma prekallikrein (r = -0.434, p less than 0.005). The levels of plasminogen, alpha 2-plasmin inhibitor and factor XIII decreased and plasma bradykinin increased in toxemia. Among the various factors, plasma AT-III and prekallikrein were the most sensitive indicators of the severity of toxemia.
authors.affiliation: Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita City, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hayakawa
authors.forename: M
authors.initials: M
authors.lastname: Maki
mesh_terms: D000941:Antigens / Q000032:analysis; D000990:Antithrombin III / Q000032:analysis / Q000276:immunology; D001777:Blood Coagulation; D001920:Bradykinin / Q000097:blood; D004211:Disseminated Intravascular Coagulation / Q000097:blood; D005176:Factor XIII / Q000032:analysis / Q000276:immunology; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D010958:Plasminogen / Q000032:analysis; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011288:Prekallikrein / Q000032:analysis; D000979:alpha-2-Antiplasmin / Q000032:analysis
chemical_list: D000941:Antigens; D000979:alpha-2-Antiplasmin; D000990:Antithrombin III; D010958:Plasminogen; D005176:Factor XIII; D011288:Prekallikrein; D001920:Bradykinin