title: Evidence of hypovitaminosis D in patients with mitral ring calcification.
abstract: In order to evaluate the role of calcium regulating hormones in the pathogenesis of mitral ring calcification, we have studied the serum levels of PTH and vitamin D metabolites in aged females both with and without mitral ring calcification (MRC). In the patients with MRC (n = 17), significantly lower levels of serum total protein (6.6 +/- 0.2 in the MRC group vs 7.1 +/- 0.1 g/dl in the control group, mean +/- SEM), BUN (15.7 +/- 0.9 vs 18.3 +/- 0.9 mg/dl), creatinine (0.7 +/- 0.02 vs 0.9 +/- 0.02 mg/dl) and calcium (8.4 +/- 0.1 vs 9.2 +/- 0.1 mg/ml) were observed as compared with those in the controls (n = 32). Significantly higher PTH levels (0.57 +/- 0.07 vs 0.38 +/- 0.04 ng/ml) were found in the MRC group. Levels of all three vitamin D metabolites in the MRC group were significantly lower than those in the control group (25-OHD; 11.2 +/- 1.4 vs 19.6 +/- 1.2 ng/ml, 24,25(OH)2D; 0.7 +/- 0.1 vs 1.3 +/- 0.1 ng/ml and 1,25(OH)2D; 12.5 +/- 2.4 vs 43.0 +/- 3.5 pg/ml). The correlation coefficient between PTH and 1,25(OH) 2D was -0.382(n = 49, p less than 0.01). Thus, the significantly higher PTH levels in the MRC group might result in hypovitaminosis D. In conclusion, evidence of hypovitaminosis D in the patients with mitral ring calcification was demonstrated.
authors.affiliation: Section of Laboratory Medicine, Tokyo Metropolitan Geriatric Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shiraki
authors.forename: A
authors.initials: A
authors.lastname: Miyagawa
authors.forename: I
authors.initials: I
authors.lastname: Akiguchi
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Ohkawa
authors.forename: M
authors.initials: M
authors.lastname: Sugiura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002114:Calcinosis / Q000097:blood; D002118:Calcium / Q000097:blood; D004100:Dihydroxycholecalciferols / Q000097:blood; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood; D006962:Hyperparathyroidism, Secondary / Q000150:complications; D008943:Mitral Valve / Q000473:pathology*; D010281:Parathyroid Hormone / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications / Q000175:diagnosis*
chemical_list: D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D002118:Calcium