Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice.
Transgenic mice were generated carrying either the long terminal repeat of Human Immunodeficiency Virus fused to the bacterial chloramphenicol acetyl transferase reporter gene or a control element of the murine alpha A crystallin gene fused to the tat gene of human immunodeficiency virus. By crossing these two strains, progeny were obtained which carried both transgenes. The bacterial reporter gene was specifically transactivated in the eyes of these animals.
Khillan
J S
JS
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892.
Deen
K C
KC
Yu
S H
SH
Sweet
R W
RW
Rosenberg
M
M
Westphal
H
H
D000123:Acetyltransferases / Q000235:genetics; D000818:Animals; D015500:Chloramphenicol O-Acetyltransferase; D003001:Cloning, Molecular; D003459:Crystallins / Q000235:genetics; D005786:Gene Expression Regulation; D015694:Gene Products, rev; D005796:Genes; D005814:Genes, Viral; D005822:Genetic Vectors; D006678:HIV / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D012191:Retroviridae Proteins / Q000235:genetics*; D054321:rev Gene Products, Human Immunodeficiency Virus
D003459:Crystallins; D015694:Gene Products, rev; D012191:Retroviridae Proteins; D054321:rev Gene Products, Human Immunodeficiency Virus; D000123:Acetyltransferases; D015500:Chloramphenicol O-Acetyltransferase