Effects of a lidocaine derivative QX-572 on CA1 neuronal responses to electrical and chemical stimuli in a hippocampal slice.
Activity of CA1 neurons was recorded in rat hippocampal slices with a lidocaine-derived QX-572-filled micropipette. The QX compound abolished Na action potentials as reported earlier. In addition it reduced markedly the burst slow afterhyperpolarization seen in these neurons in response to a depolarizing current pulse. It also modified responses to neurotransmitter substances associated with changes in K currents, acetylcholine and serotonin. QX-filled micropipettes can therefore provide some insight into mechanisms of action of certain neurotransmitters in the brain but they cannot be used as selective blockers of Na currents.
Segal
M
M
Center for Neurosciences, Weizmann Institute of Science, Rehovot, Israel.
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology
D012701:Serotonin; D008012:Lidocaine; D000109:Acetylcholine; C006110:carcainium chloride