The morphological study of copper chloride-induced lesions in isolated heart.
Rat hearts isolated according to Langendorff were perfused with Krebs-Henseleit medium containing 10(-7)-10(-4) mol/l CuCl2 solution. Using morphological studies combined with electron microscopic and cytochemical techniques, it was established that, by contrast to other tracer elements, severe lesions initially affect the capillary endothelium then the fibre system, being first characterized by edema of the capillary wall, accumulated pinocytotic vesicles and later by hyperconcentration necrosis. Using a concentration of 10(-4) mol/l, oxygen-paradox- or calcium-paradox-type impairments develop.
Patai
K
K
2nd Department of Obstetrics and Gynaecology, Semmelweis University Medical School, Budapest, Hungary.
Balogh
I
I
D000818:Animals; D003300:Copper / Q000633:toxicity*; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000473:pathology; D051381:Rats
D003300:Copper