Kinetic arguments for the existence of a single form of intestinal ornithine decarboxylase during the postnatal development of normal and sparse-fur mutant mice and after EGF treatment.
The Km for ornithine is remarkably constant during the course of postnatal development in both normal and spf mutant mice even if a large but transient increase in ornithine decarboxylase (ODC) activity is noted. Four hours after EGF injection (4 micrograms/g b.wt) to 17-day-old normal and spf mice, a marked stimulation of ODC activity is observed but Km remains unaffected. These data argue against the existence of multiple forms of ODC in the intestinal mucosa of mice.
Malo
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Department of Physiology, Faculty of Medicine, University of Montreal, Québec, Canada.
D000367:Age Factors; D000818:Animals; D004815:Epidermal Growth Factor / Q000502:physiology*; D007422:Intestines / Q000201:enzymology* / Q000254:growth & development; D007700:Kinetics; D051379:Mice; D008817:Mice, Mutant Strains / Q000502:physiology; D009955:Ornithine Decarboxylase / Q000172:deficiency / Q000378:metabolism*
D004815:Epidermal Growth Factor; D009955:Ornithine Decarboxylase