Heterophile Hanganutziu-Deicher antigen in ganglioside fractions of human melanoma tissues.
Gangliosides were purified from melanoma tissue extracts obtained from 5 patients. GM3 and GD3 were identified as the major components in ganglioside fractions of the melanoma tissues. Following thin-layer chromatography, enzyme immunostaining with Hanganutziu-Deicher (H-D) antigen-specific chicken antisera demonstrated the presence of NeuGc-neolactotetraosylceramide (H-D5) and NeuGc-lacto-N-norhexa-osylceramide (H-D7) in all 5 melanoma extracts.
Kawachi
S
S
Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
Saida
T
T
Uhara
H
H
Uemura
K
K
Taketomi
T
T
Kano
K
K
D000910:Antibodies, Heterophile / Q000276:immunology*; D015478:Antigens, Heterophile / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D005732:Gangliosides / Q000032:analysis*; D006801:Humans; D008545:Melanoma / Q000032:analysis / Q000276:immunology*
D000910:Antibodies, Heterophile; D015478:Antigens, Heterophile; D000951:Antigens, Neoplasm; D005732:Gangliosides