The effect of buthobendin on glycolysis in rabbit myocardial slices in vitro.
The effect of buthobendin (2S,2'S isomer of N,N'-dimethyl N,N'-bis[1-(3',4',5'-trimethoxybenzoyloxy)-butyl-2]-ethylenediamin e dihydrochloride), (CravitenR) on aerobic and anaerobic glycolysis in rabbit myocardial slices was compared with that of the biologically inactive isomer 2R,2'R and the well-known antiarrhythmic drugs quinidine and procainamide. Only buthobendin stimulated lactate formation under anaerobic and aerobic conditions. However, that effect was not accompanied with a parallel increase in the glucose uptake, but was related to a decrease in the glycogen level. This finding might indicate that buthobendin stimulates glycolysis by mobilization of the glycogen degradation.
Marchut
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E
Institute of Medical Biochemistry, N. Copernicus Medical Academy, Kraków, Poland.
Gumińska
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M
Kedryna
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T
D000332:Aerobiosis; D000693:Anaerobiosis; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D005029:Ethylenediamines / Q000494:pharmacology*; D006019:Glycolysis / Q000187:drug effects*; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D007773:Lactates / Q000096:biosynthesis; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010766:Phosphorylation; D011342:Procainamide / Q000494:pharmacology; D011802:Quinidine / Q000494:pharmacology; D011817:Rabbits
D000889:Anti-Arrhythmia Agents; D005029:Ethylenediamines; D007773:Lactates; C030706:butobendin; D011802:Quinidine; D011342:Procainamide