[Synthesis and biological activity of 5-phenyl-1,3,4-benzotriazepines. 14. The reactions of 2-thioxo-5-phenyl-1,3,4-benzotriazepines].
The interaction of 2-aminoethanol and 2-thioxo-5-phenyl-1,3,4-benzotriazepines in abs. dioxane under refluxing conditions was investigated. Depending on the substitution of the triazepine ring several products are formed. The S-N-exchange to form the corresponding 2-(2-hydroxyethyl)-amino derivatives only takes place if the nitrogen atoms of the heterocycle are unsubstituted.
Morgenstern
O
O
Sektion Pharmazie, Ernst-Moritz-Arndt-Universität Greifswald.
Besch
A
A
Richter
P
P
D055598:Chemical Phenomena; D002621:Chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D013871:Thiones / Q000138:chemical synthesis
D006571:Heterocyclic Compounds; D013871:Thiones
Synthese und biologische Aktivität von 5-phenyl-1,3,4-benzotriazepinen. 14 Mitteilung: Untersuchungen zur Reaktion von 2-Thioxo-5-phenyl-1,3,4-benzotriazepinen mit 2-Aminoethanol.