Enhancement of human immunodeficiency virus production by natural lymphotoxin.
The effect of natural lymphotoxin (n-LT) on CD4+ MOLT-4 cells and those cells producing human immunodeficiency virus (HIV), MOLT-4/HIVHTLV-IIIB cells, was studied. Four days after treatment with n-LT, a significant cytotoxic/cytostatic effect was observed predominantly on MOLT-4/HIVHTLV-IIIB cells. Furthermore, with regard to the production of HIV, an almost 3- to 5-fold increase of viral particles was observed in MOLT-4/HIVHTLV-IIIB cells 6 h after treatment with n-LT. These data indicate the possibility that this cytotoxic factor is one of the responsible molecules in the pathogenesis of the acquired immunodeficiency syndrome (AIDS).
Matsuyama
T
T
Department of Virology and Parasitology, Yamaguchi University School of Medicine, Japan.
Hamamoto
Y
Y
Kobayashi
S
S
Kurimoto
M
M
Minowada
J
J
Kobayashi
N
N
Yamamoto
N
N
D000911:Antibodies, Monoclonal; D002460:Cell Line; D006678:HIV / Q000187:drug effects / Q000254:growth & development*; D006801:Humans; D007700:Kinetics; D008233:Lymphotoxin-alpha / Q000302:isolation & purification / Q000494:pharmacology*
D000911:Antibodies, Monoclonal; D008233:Lymphotoxin-alpha