title: [Preclinical toxicologic study of glyciram].
abstract: A preclinical study of safety of a plant preparation glyciram was carried out. At a single administration to laboratory animals the preparation is virtually a nontoxic compound. Intragastric administration of glyciram for 6 months in doses of 100 and 250 mg/kg may produce in animals functional changes of the liver and kidneys, which one should take into consideration when prescribing the preparation to patients suffering from diseases of these organs. The use of glyciram in doses of from 10 to 250 mg/kg causes no remote consequences--allergic, immunodepressive reactions, embryo-toxic, teratogenic and mutagenic effects.
authors.forename: T A
authors.initials: TA
authors.lastname: Tataurova
authors.forename: L V
authors.initials: LV
authors.lastname: Krepkova
authors.forename: V V
authors.initials: VV
authors.lastname: Bortnikova
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Kuznetsova
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Eniutina
mesh_terms: D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects; D001774:Blood Chemical Analysis; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D006034:Glycyrrhetinic Acid / Q000633:toxicity*; D007166:Immunosuppressive Agents; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009152:Mutagenicity Tests; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D006034:Glycyrrhetinic Acid
vernacular_title: Toksikologicheskoe doklinicheskoe izuchenie glitsirama.