[Corticosterone receptor binding by various brain structures in extreme body states].
Studies on receptor binding of 3H-corticosterone in different brain structures of mature Wistar rats after a single x-irradiation at a dose of 12.9 mCoul/kg, short-term vertical vibration, glucocorticoid application, and surgical adrenalectomy showed a high sensitivity of all studied structures to the body level of glucocorticoids. Any of these influences caused redistribution of receptor binding of 3H-corticosterone in all brain structures, with a marked effect in the parietal cortex and mediobasal hypothalamus, which characterized the central mechanisms of regulation of the pituitary-adrenal system under extreme influences.
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D000315:Adrenalectomy; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D003345:Corticosterone / Q000378:metabolism* / Q000528:radiation effects; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D011987:Receptors, Steroid; D014316:Tritium; D014732:Vibration / Q000009:adverse effects
D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; C024357:corticosterone receptor; D014316:Tritium; C021650:hydrocortisone acetate; D003345:Corticosterone; D006854:Hydrocortisone
Retseptornoe sviazyvanie kortikosterona razlichnymi strukturami golovnogo mozga pri ékstremal'nykh sostoianiiakh organizma.