Activity of protein kinase C in erythrocytes in primary hypertension.
The activity of protein kinase C and A was studied in the erythrocytes of patients with essential hypertension (EH) and in spontaneously hypertensive rats (SHR, Okamoto-Aoki strain). Protein kinase C activity was also studied in the erythrocytes of patients with hypertension of renal origin. Protein kinase C activity in the lysate of erythrocytes of patients with EH and in SHR was found to be increased 1.6-2.0-fold as compared to that in normotensive controls. No notable differences in protein kinase A activity were observed between hypertensive and normotensive groups. In erythrocytes of patients with renal hypertension, no notable changes in protein kinase C activity were revealed.
Kravtsov
G M
GM
Central Research Laboratory, Ministry of Public Health, Moscow, USSR.
Dulin
N O
NO
Postnov
Y V
YV
D000328:Adult; D000818:Animals; D002118:Calcium / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D010718:Phosphatidylserines / Q000097:blood; D011493:Protein Kinase C / Q000097:blood*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D010718:Phosphatidylserines; D011493:Protein Kinase C; D002118:Calcium