HLA-DR-expressing cells and T-lymphocytes in sural nerve biopsies.
Thirty-five sural nerve biopsies were stained immunohistochemically for HLA-DR antigen. HLA-DR was expressed on nonmyelinating Schwann cells, macrophages, vascular endothelium, and perineurium. By means of double immunofluorescence staining the identity of the HLA-DR presenting structures was confirmed. HLA-DR expression was found in all biopsies and thus was not restricted to any particular type of neuropathy. The HLA-DR expression appeared to correlate with severity and activity of the neuropathy. HLA-DR-expressing macrophages wrapping myelinated fibers were prominent in primary demyelinating neuropathies. T-cells were found in 6 out of 15 nerves examined. Their presence correlated with moderate to strong HLA-DR expression of nonmyelinating Schwann cells, and they occurred during active disease.
Schrøder
H D
HD
Department of Pathology, Karolinska Institute, Huddinge Hospital, Sweden.
Olsson
T
T
Solders
G
G
Kristensson
K
K
Link
H
H
D000328:Adult; D000368:Aged; D001706:Biopsy; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008264:Macrophages / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000175:diagnosis*; D012583:Schwann Cells / Q000473:pathology; D013127:Spinal Nerves / Q000473:pathology*; D013497:Sural Nerve / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology*
D006684:HLA-DR Antigens