title: Immature optic nerve glia of rat do not promote axonal regeneration when transplanted into a peripheral nerve.
abstract: The ability of immature central nervous system (CNS) glia to promote axonal regeneration was studied by grafting segments of embryonic and neonatal rat optic nerves into the sciatic nerves of adult rats. Unexpectedly, very few axons regenerated through these grafts. The majority of the axons bypassed the grafts and were associated with Schwann cells. These results were similar to those obtained with grafts of adult rat optic nerves. The failure of immature CNS glia to promote axonal regeneration under these conditions suggests that they may be less effective than Schwann cells in promoting the regeneration and growth of axons.
authors.affiliation: Department of Neurology, Montreal General Hospital Research Institute, McGill University, Que., Canada.
authors.forename: N
authors.initials: N
authors.lastname: Giftochristos
authors.forename: S
authors.initials: S
authors.lastname: David
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001369:Axons / Q000502:physiology*; D002452:Cell Count; D005260:Female; D009416:Nerve Regeneration; D009457:Neuroglia / Q000502:physiology*; D009900:Optic Nerve / Q000196:embryology / Q000502:physiology / Q000637:transplantation*; D051381:Rats; D011917:Rats, Inbred Lew; D012584:Sciatic Nerve / Q000502:physiology*