F-18 deoxyglucose and stress N-13 ammonia positron emission tomography in anterior wall healed myocardial infarction.
To evaluate myocardial blood flow and glucose utilization, N-13 ammonia (NH3) and F-18 deoxyglucose positron emission tomography scanning was performed in 22 patients with previous anterior wall myocardial infarction, using a high-resolution, multi-slice, whole-body scanner. The N-13 ammonia study was performed at rest and after exercise. The F-18 deoxyglucose study was performed at rest after fasting greater than 5 hours. The N-13 ammonia study revealed a hypoperfused area in 19 of the 22 patients (86%), that corresponded to the infarcted regions as diagnosed by electrocardiography, coronary arteriography and left ventriculography (21 patients). The hypoperfused areas expanded after exercise in 16 of 22 patients (73%). F-18 deoxyglucose uptake was observed in these hypoperfused areas, especially in patients with hypokinetic wall motion on left ventriculography and in exercise-induced hypoperfused areas. However, positron emission tomography demonstrated diffuse uptake of F-18 deoxyglucose in 3 of 8 patients with dyskinetic wall motion. Thus, metabolically active myocardium in infarcted areas or periinfarct ischemia can be visualized with F-18 deoxyglucose and stress N-13 ammonia studies.
Fudo
T
T
Department of Internal Medicine, Kyoto University, Japan.
Kambara
H
H
Hashimoto
T
T
Hayashi
M
M
Nohara
R
R
Tamaki
N
N
Yonekura
Y
Y
Senda
M
M
Konishi
J
J
Kawai
C
C
D000328:Adult; D000368:Aged; D000641:Ammonia; D003326:Coronary Circulation; D003837:Deoxy Sugars; D003847:Deoxyglucose; D005080:Exercise Test; D005462:Fluorine Radioisotopes; D005947:Glucose / Q000378:metabolism; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009590:Nitrogen Radioisotopes; D014055:Tomography, Emission-Computed / Q000295:instrumentation / Q000379:methods*
D003837:Deoxy Sugars; D005462:Fluorine Radioisotopes; D009590:Nitrogen Radioisotopes; D000641:Ammonia; D003847:Deoxyglucose; D005947:Glucose