Absorption of nicotine from a cigarette that does not burn tobacco.
Ten smokers participated in a study to compare the absorption of nicotine from the smoke aerosol of a new cigarette that heats, but does not burn tobacco (test) with a cigarette that burns tobacco (reference). The average plasma nicotine concentrations obtained by the 7th test cigarette (13 ng/ml) and 7th reference cigarette (24 ng/ml) were proportional to the nicotine yielded by the two cigarettes as determined under Federal Trade Commission machine-smoking conditions. These data demonstrate that the smoke aerosol obtained by smoking a cigarette which heats tobacco produces plasma profiles of nicotine that are similar to the profiles obtained from smoking a cigarette that burns tobacco.
deBethizy
J D
JD
Bowman Gray Technical Center, R.J. Reynolds Tobacco Company, Winston-Salem, N.C.
Robinson
J H
JH
Davis
R A
RA
Doolittle
D J
DJ
Burger
G T
GT
Reynolds
J H
JH
Fletcher
R G
RG
Hayes
A W
AW
D000042:Absorption; D000328:Adult; D000336:Aerosols; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000097:blood*; D010947:Plants, Toxic; D012906:Smoke / Q000032:analysis; D012907:Smoking / Q000097:blood*; D014026:Nicotiana
D000336:Aerosols; D012906:Smoke; D009538:Nicotine