Effects of mephenytoin on schedule-controlled responding in the pigeon.
Acute and chronic effects of mephenytoin (30-360 mg/kg) were examined in pigeons responding under a multiple fixed-ratio 50 fixed-interval 90-sec schedule of food delivery. The highest dose administered acutely (240 mg/kg) produced substantial reductions in rate of responding under both components of the multiple schedule; the effects of other doses were small and inconsistent. With chronic exposure tolerance appeared to develop to the rate-decreasing effects of the drug.
Pellettiere
V
V
Department of Psychology, Western Michigan University, Kalamazoo 49008.
Delaney
D
D
Schlinger
H
H
Poling
A
A
D000818:Animals; D010856:Columbidae; D005502:Food; D006827:Hydantoins / Q000494:pharmacology*; D008617:Mephenytoin / Q000008:administration & dosage / Q000494:pharmacology*; D011930:Reaction Time; D012055:Reinforcement Schedule
D006827:Hydantoins; D008617:Mephenytoin