title: Synthesis and biological activity of some new pyrimidine and thienopyrimidine derivatives.
abstract: The readily available 4-mercapto-6-methyl-2-phenyl-5-acetylpyrimidine (1) was alkylated with a variety of activated halomethylene compounds to give the corresponding thieno [2,3-d] pyrimidine derivatives 3a-h via the intermediate alkylmercaptopyrimidine derivatives 2b-h. The biological activity of the new compounds was screened against several strains of bacteria.
authors.affiliation: Department of Chemistry, Faculty of Science, Zagazig University, ARE.
authors.forename: S
authors.initials: S
authors.lastname: el-Bahaie
authors.forename: A M
authors.initials: AM
authors.lastname: Kadry
authors.forename: M G
authors.initials: MG
authors.lastname: Assy
authors.forename: Y A
authors.initials: YA
authors.lastname: Ibrahim
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D011743:Pyrimidines