title: The CNS effects of 5-aminobenzoic acids inhibiting the biosynthesis of prostaglandins.
abstract: It was found that the 2,5-diaminobenzoic acid derivatives 1 activating the biosynthesis of prostaglandins have CNS side effects. The replacement of the 2-NH group in 1 by O or S resulted an inhibition of prostaglandin biosynthesis and increased CNS activity.
authors.affiliation: Institute for Drug Research, Budapest, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Kosáry
authors.forename: I
authors.initials: I
authors.lastname: Kovács-Szabó
authors.forename: I
authors.initials: I
authors.lastname: Király
authors.forename: E
authors.initials: E
authors.lastname: Kasztreiner
mesh_terms: D062365:Aminobenzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D002492:Central Nervous System Depressants / Q000138:chemical synthesis*; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011453:Prostaglandins / Q000096:biosynthesis*; D013055:Spectrophotometry, Infrared
chemical_list: D062365:Aminobenzoates; D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D011453:Prostaglandins