Phenobarbital adsorption from simulated intestinal fluid, U.S.P., and simulated gastric fluid, U.S.P., by two activated charcoals.
Adsorption of phenobarbital from simulated intestinal and gastric fluids by two activated charcoals was studied. Adsorption isotherm data were analyzed by the linearized Langmuir equation and by nonlinear least-squares regression employing both Langmuir and Freundlich models. These analyses indicated differences in the capacities of the two charcoals for phenobarbital which could not be completely explained by surface-area considerations.
Wurster
D E
DE
College of Pharmacy, University of Iowa, Iowa City 52242.
Burke
G M
GM
Berg
M J
MJ
Veng-Pedersen
P
P
Schottelius
D D
DD
D000327:Adsorption; D002606:Charcoal; D005750:Gastric Juice / Q000378:metabolism*; D007419:Intestinal Secretions / Q000378:metabolism*; D010634:Phenobarbital / Q000493:pharmacokinetics*
D002606:Charcoal; D010634:Phenobarbital