Severe combined immunodeficiency with T lymphocytes retaining functional activity.
Two cases of severe combined immunodeficiency (SCID) with normal numbers of T cells are reported. Studies of T-cell subsets showed an absence of TQ1+ lymphocytes and a very low percentage of CD4+ cells in Patient 2. Functional studies of T cells from this patient showed a normal suppressor activity. Patient 1 had normal percentages of T-cell subsets and his lymphocytes showed helper and suppressor activities but to a lesser degree than normal controls. Both cases stressed the heterogeneity of SCID in which T cells could be present and retain some of their functional activities.
Fontán
G
G
Immunology Service, Ciudad Sanitaria La Paz, Madrid, Spain.
García Rodriguez
M C
MC
Carrasco
S
S
Zabay
J M
JM
de la Concha
E G
EG
D000911:Antibodies, Monoclonal; D000917:Antibody Formation; D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis; D003078:Colchicine / Q000494:pharmacology; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007152:Immunologic Capping / Q000187:drug effects; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007223:Infant; D008213:Lymphocyte Activation; D008214:Lymphocytes; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D006680:HLA Antigens; D003078:Colchicine