title: [Comparative study of the interaction of acetylcholinesterases of human erythrocytes and the heads of houseflies with phosphorylated alkylchloroformoximes].
abstract: Studies have been made on the interaction of four types of phosphorylated alkylchloroformoximes, i.e. analogues of an insecticide-acaricide valexon, with acetylcholinesterases from human erythrocytes and from the heads of the housefly Musca domestica. Antiacetylcholinesterase activity of the drugs depended both on the structure of the organophosphorus compounds, and the origin of the enzyme, indicating the existence of differences in the active surface of these acetylcholinesterases. Incorporation of one or two chloride atoms into alkylchloroformoxime group of the cleaved part of the organophosphorus compounds increased anticholinesterase activity with respect to both enzymes. Diethyl derivatives of these drugs exhibited higher specificity with respect to housefly enzyme as compared to human acetylcholinesterase.
authors.forename: G A
authors.initials: GA
authors.lastname: Shataeva
authors.forename: G F
authors.initials: GF
authors.lastname: Makhaeva
authors.forename: V L
authors.initials: VL
authors.lastname: Iankovskaia
authors.forename: V B
authors.initials: VB
authors.lastname: Sokolov
authors.forename: A N
authors.initials: AN
authors.lastname: Ivanov
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004347:Drug Interactions; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D006257:Head / Q000187:drug effects / Q000201:enzymology; D006793:Houseflies / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D007306:Insecticides / Q000494:pharmacology*; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D002800:Cholinesterase Inhibitors; D007306:Insecticides; D009946:Organothiophosphorus Compounds; C003135:phoxim; D000110:Acetylcholinesterase
vernacular_title: Sravnitel'noe izuchenie vzaimodeĭstviia atsetilkholinésteraz éritrotsitov cheloveka i golov komnatnykh mukh s fosforilirovannymi alkilkhlorformoksimami.