[Effect of interleukin-1 on adrenal function in mice].
The influence of macrophage secretion product on the functional activity of the adrenal glands has been studied in mice. It has been shown that intravenously injected interleukin-1 caused dose-dependent increase in corticosterone content in the blood plasma. The hormonal response of the adrenal glands to interleukin-1 injection was abolished by the inhibition of prostaglandin synthesis. The results obtained indicate that interleukin-1 stimulates the functional activity of the adrenal glands, with the effect mediated by prostaglandins.
Krymskaia
L G
LG
Gromykhina
N Iu
NIu
Kozlov
V A
VA
D000311:Adrenal Glands / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000917:Antibody Formation; D003345:Corticosterone / Q000097:blood; D007375:Interleukin-1 / Q000378:metabolism / Q000494:pharmacology*; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA
D007375:Interleukin-1; D003345:Corticosterone
Vliianie interleĭkina-1 na funktsional'nuiu aktivnost' nadpochechnikov u mysheĭ.