title: Increase in ganglion cell size after optic nerve regeneration in the frog, Rana pipiens.
abstract: Even though optic regeneration is successful in the frog, Rana pipiens, at completion considerable ganglion cell loss has occurred. To determine whether ganglion cell loss affects the size of the remaining ganglion cells, these cells were back-filled with horseradish peroxidase. The size of one class of ganglion cell 6 months to 1 year following nerve crush injury (N = 4) was compared to that of normal cells of this class (N = 4). The average area of the perikaryon was 35% larger than normal (less than 0.01). This change is interpreted to reflect the increased metabolic needs of the neuron required to maintain a larger than normal axonal arbor.
authors.affiliation: Department of Anatomy and Cell Biology, SUNY Health Science Center, Syracuse 13210.
authors.forename: D J
authors.initials: DJ
authors.lastname: Stelzner
authors.forename: J A
authors.initials: JA
authors.lastname: Strauss
mesh_terms: D000818:Animals; D009416:Nerve Regeneration; D009900:Optic Nerve / Q000502:physiology*; D011894:Rana pipiens; D012160:Retina / Q000166:cytology*; D012165:Retinal Ganglion Cells / Q000166:cytology*