Effect of hyperthermia on growth of Ehrlich ascites tumor cells.
Hyperthermic treatment at 43 degrees C suppressed the growth of Ehrlich ascites tumor (EAT) cells in vitro. Incubation of EAT cells at 43 degrees C for as little as 1.5 h totally abolished the transplantability of the tumor. At the same time, the rate of cellular glucose uptake, the density of glucose transporter on the cells as well as the extent of thymidine, uridine and leucine incorporation were significantly reduced.
Fung
K P
KP
Department of Biochemistry, Chinese University of Hong Kong/Shatin.
Lam
W P
WP
Wen
H L
HL
Choy
Y M
YM
Lee
C Y
CY
D000818:Animals; D001665:Binding Sites; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism* / Q000473:pathology; D003571:Cytochalasin B; D003847:Deoxyglucose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006979:Hyperthermia, Induced; D007930:Leucine / Q000378:metabolism; D051379:Mice; D009368:Neoplasm Transplantation; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D003571:Cytochalasin B; D003847:Deoxyglucose; D007930:Leucine; D005947:Glucose; D013936:Thymidine; D014529:Uridine