title: Effect of tranexamic acid on gastric bleeding in rats.
abstract: Bleeding from an induced gastric mucosal wound was monitored for 2 h in a rat model, in which normal hemostasis was disturbed mechanically by perfusing the lesion with saline. The hemorrhage was characterized by continuous bleeding and/or episodes of spontaneous rebleeding, as often seen in patients with gastric hemorrhage. The antifibrinolytic agent, tranexamic acid, significantly reduced total bleeding volume and number of rebleeding episodes, suggesting that plasmin-induced fibrinolysis might aggravate gastric mucosal hemorrhage.
authors.affiliation: Division of Gastroenterology, University of Alabama, Birmingham.
authors.forename: A
authors.initials: A
authors.lastname: Berstad
authors.forename: K
authors.initials: K
authors.lastname: Almodovar
authors.forename: K
authors.initials: K
authors.lastname: Berstad
authors.forename: W
authors.initials: W
authors.lastname: Anderson
authors.forename: B I
authors.initials: BI
authors.lastname: Hirschowitz
mesh_terms: D000818:Animals; D003509:Cyclohexanecarboxylic Acids / Q000008:administration & dosage*; D005342:Fibrinolysis / Q000187:drug effects; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D007262:Infusions, Intravenous; D051381:Rats; D011919:Rats, Inbred Strains; D014148:Tranexamic Acid / Q000008:administration & dosage*
chemical_list: D003509:Cyclohexanecarboxylic Acids; D014148:Tranexamic Acid