title: Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling.
abstract: Proteins undergo a series of nonenzymatic reactions with glucose over time to form advanced glycosylation end products (AGEs). Macrophages have a receptor that recognizes the AGE moiety and mediates the uptake and degradation of AGE proteins. This removal process is associated with the production and secretion of cachectin (tumor necrosis factor) and interleukin-1, two cytokines with diverse and seemingly paradoxical biological activities. The localized release and action of these cytokines could account for the coordinated removal and replacement of senescent extracellular matrix components in normal tissue homeostasis.
authors.affiliation: Laboratory of Medical Biochemistry, Rockefeller University, New York, NY 10021.
authors.forename: H
authors.initials: H
authors.lastname: Vlassara
authors.forename: M
authors.initials: M
authors.lastname: Brownlee
authors.forename: K R
authors.initials: KR
authors.lastname: Manogue
authors.forename: C A
authors.initials: CA
authors.lastname: Dinarello
authors.forename: A
authors.initials: A
authors.lastname: Pasagian
mesh_terms: D006031:Glycosylation; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000235:genetics; D007700:Kinetics; D008562:Membrane Glycoproteins / Q000502:physiology*; D009000:Monocytes / Q000378:metabolism*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D007375:Interleukin-1; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha