title: Absorption of nicotine from a cigarette that does not burn tobacco.
abstract: Ten smokers participated in a study to compare the absorption of nicotine from the smoke aerosol of a new cigarette that heats, but does not burn tobacco (test) with a cigarette that burns tobacco (reference). The average plasma nicotine concentrations obtained by the 7th test cigarette (13 ng/ml) and 7th reference cigarette (24 ng/ml) were proportional to the nicotine yielded by the two cigarettes as determined under Federal Trade Commission machine-smoking conditions. These data demonstrate that the smoke aerosol obtained by smoking a cigarette which heats tobacco produces plasma profiles of nicotine that are similar to the profiles obtained from smoking a cigarette that burns tobacco.
authors.affiliation: Bowman Gray Technical Center, R.J. Reynolds Tobacco Company, Winston-Salem, N.C.
authors.forename: J D
authors.initials: JD
authors.lastname: deBethizy
authors.forename: J H
authors.initials: JH
authors.lastname: Robinson
authors.forename: R A
authors.initials: RA
authors.lastname: Davis
authors.forename: D J
authors.initials: DJ
authors.lastname: Doolittle
authors.forename: G T
authors.initials: GT
authors.lastname: Burger
authors.forename: J H
authors.initials: JH
authors.lastname: Reynolds
authors.forename: R G
authors.initials: RG
authors.lastname: Fletcher
authors.forename: A W
authors.initials: AW
authors.lastname: Hayes
mesh_terms: D000042:Absorption; D000328:Adult; D000336:Aerosols; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000097:blood*; D010947:Plants, Toxic; D012906:Smoke / Q000032:analysis; D012907:Smoking / Q000097:blood*; D014026:Nicotiana
chemical_list: D000336:Aerosols; D012906:Smoke; D009538:Nicotine