Urinary excretion kinetics of p-nitrophenol following oral administration of parathion in the rabbit.
The urinary excretion kinetics of p-nitrophenol were studied in rabbits following oral administration of parathion at a dose of 3 mg/kg. Elimination of p-nitrophenol began rapidly, and of the total amount excreted during the study period, 46% was excreted in the first 3 h; 85% was excreted at 6 h after administration of the pesticide. The mean maximum excretion rate of p-nitrophenol was 111.15 +/- 61.02 micrograms/h reached in a time of 0.77 +/- 0.26 h. The formation and disappearance rate constants of the metabolite were 2.85 +/- 2.80 h-1 and 0.80 +/- 0.28 h-1, respectively. A linear relationship was observed between the plasma concentrations of parathion and the urinary excretion rate of p-nitrophenol.
Peña-Egido
M J
MJ
Department of Food Science, Toxicology and Chemical Analysis, Faculty of Pharmacy, University of Salamanca, Spain.
Mariño-Hernandez
E L
EL
Santos-Buelga
C
C
Rivas-Gonzalo
J C
JC
D000284:Administration, Oral; D000818:Animals; D008297:Male; D009596:Nitrophenols / Q000652:urine*; D010278:Parathion / Q000493:pharmacokinetics* / Q000633:toxicity; D011817:Rabbits
D009596:Nitrophenols; D010278:Parathion; C024836:4-nitrophenol