The synthesis of two repeating units of Haemophilus influenzae type a capsular antigen.
The repeating units 2-O-beta-D-glucopyranosyl-L-ribitol 4'- and 1-phosphate of Haemophilus influenzae type a capsular antigen have been synthesised by condensation of an alpha-D-glucopyranosyl bromide derivative with 5-O-allyl-1,2,3-tri-O-benzyl-D-ribitol followed by selective deprotection of HO-4' or HO-1, phosphorylation, and removal of the blocking groups.
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Institute of Organic Chemistry, Polish Academy of Sciences, Warszawa.
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Zamojski
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D000942:Antigens, Bacterial; D016667:Bacterial Capsules; D001428:Bacterial Vaccines; D004187:Disaccharides / Q000138:chemical synthesis*; D018073:Haemophilus Vaccines; D006193:Haemophilus influenzae / Q000276:immunology*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009904:Optical Rotation; D011135:Polysaccharides, Bacterial / Q000138:chemical synthesis*; D013402:Sugar Alcohols / Q000138:chemical synthesis*; D013403:Sugar Phosphates / Q000138:chemical synthesis*
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D004187:Disaccharides; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D007202:Indicators and Reagents; D011135:Polysaccharides, Bacterial; D013402:Sugar Alcohols; D013403:Sugar Phosphates; C056714:2-O-glucopyranosylribitol-4'-phosphate; C056715:2-O-glucopyranosylribitol-1-phosphate