title: Depletion of protein kinase C induced by an anti HLA class I monoclonal antibody in phytohemagglutinin activated human T cells.
abstract: Anti HLA Class I Monoclonal Antibody depletes Protein Kinase C (PKC) to 20% of control value in PHA activated human T cells. The effect is reversible: in 24 hours the enzymatic activity returns to 58% of control value. Removal of antibody from the culture medium increases the rate of recovery. Implications of this finding for the modulation by HLA Class I antigens of the proliferative response of T cells to lectins are discussed.
authors.affiliation: Istituto di Genetica Medica, Università degli Studi di Ferrara, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Poltronieri
authors.forename: E
authors.initials: E
authors.lastname: Melloni
authors.forename: M
authors.initials: M
authors.lastname: Rubini
authors.forename: R
authors.initials: R
authors.lastname: Selvatici
authors.forename: C
authors.initials: C
authors.lastname: Mazzilli
authors.forename: R
authors.initials: R
authors.lastname: Baricordi
authors.forename: E
authors.initials: E
authors.lastname: Gandini
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D002478:Cells, Cultured; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology*; D011493:Protein Kinase C / Q000378:metabolism*; D013601:T-Lymphocytes / Q000187:drug effects / Q000201:enzymology*
chemical_list: D000911:Antibodies, Monoclonal; D006680:HLA Antigens; D010835:Phytohemagglutinins; D011493:Protein Kinase C