Epimerization kinetics of moxalactam in frozen solution.
The epimerization rate constants of R- and S-epimers of moxalactam (LMOX) in a frozen aqueous solution decreased as the temperature decreased. The reaction proceeded in the unfrozen region remaining in the frozen solution, without being affected by the ice. The reaction stopped completely below the collapse temperature of the LMOX aqueous solution. The ratio of R- and S-epimers at equilibrium, which was equal to the ratio of the epimerization rate constant, increased as the temperature decreased. This change in the ratio at equilibrium could be ascribed to the difference in the activation energy between the two epimers.
Hashimoto
N
N
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Ichihashi
T
T
Yamamoto
E
E
Hirano
K
K
Inoue
M
M
Tanaka
H
H
Yamada
H
H
D002851:Chromatography, High Pressure Liquid; D005615:Freezing; D009070:Moxalactam / Q000032:analysis*; D012996:Solutions; D013237:Stereoisomerism; D013696:Temperature; D013997:Time Factors
D012996:Solutions; D009070:Moxalactam