[Immunocytological characteristics of primary lesions of the lymph nodes in children with lymphogranulomatosis].
Antilymphocytic monoclonal antibodies of UKO and OKT series were used to study surface lymphocytic antigens in 40 primarily affected lymphatic nodes in 19 children with lymphogranulomatosis. In 17 lymphatic nodes immunological reaction was determined as the T-type (OKT3+--42.3 +/- 2.73%); and in 23--the T-cell population depletion was revealed (OKT3+--15.1 +/- 1.37%, P less than 0.001). It was shown that in the course of the disease the depletion of T-cell lymphocytic population comes more rapidly than that of B-cell. It is accompanied by an increase in the number of lymphocytes carring Ia-like antigens on the membrane (UKO-1+).
Torubarova
N A
NA
Dolotova
L V
LV
Susuleva
N A
NA
D000293:Adolescent; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006689:Hodgkin Disease / Q000276:immunology / Q000473:pathology*; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D014408:Biomarkers, Tumor
Immunotsitologicheskie osobennosti pervichno porazhennykh limfaticheskikh uzlov u deteĭ s limfogranulematozom.