In vitro studies with selectively lipid adsorbing materials.
A new synthetic material was developed by ASAHI Chemical Industry Co., Ltd., Tokyo, Japan. In vitro studies revealed selective bindings of cholesterol, LDL (low density lipids) and beta-lipoprotein by this material. Maximal bindings were reached within 1 min, and therefore, the affinities of the LDL-adsorbent to these lipid components seem to be high. In contrast to these results the plasma values of HDL (high density lipids) and apoprotein A remained nearly unchanged. Triglycerides were removed only moderately. Investigations about lipid removing capacity of the new material with the plasma of patient with familiar hypercholesterolemia and studies about interactions with the complement system were also promising. Synthetic materials which are under development in G.D.R. showed similar lipid binding capacities.
Behm
E
E
Department of Internal Medicine, Wilhelm-Pieck-University, Rostock, GDR.
Toewe
D
D
Kuroda
T
T
Yamawaki
N
N
Tsuda
N
N
Loth
F
F
Klinkmann
H
H
D000180:Acrylic Resins; D000327:Adsorption; D002482:Cellulose; D004573:Electrolytes; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*
D000180:Acrylic Resins; D004573:Electrolytes; D008077:Lipoproteins, LDL; C006903:carbopol 940; D002482:Cellulose