Cholecystokinin-58 is the major molecular form in man, dog and cat but not in pig, beef and rat intestine.
Cholecystokinin (CCK)-58 was found to be the most abundant form in upper small intestinal mucosa of man, dog and cat. However, in pig, beef and rat upper small intestinal mucosa CCK-33/39 and smaller CCK-forms were dominant. The differences in the distribution of the molecular forms of cholecystokinin between these species presumably reflects altered posttranslational processing of procholecystokinin. This may be caused by the different feeding habits of the investigated species. The different forms of cholecystokinin were distributed over the entire length of the mucosa in canine small intestine. The total amount of CCK decreased from the duodenal mucosa towards the colon. In the canine duodenal mucosa, CCK-58 accounted for 85% of the total CCK-like immunoreactivity. The relative amounts of small forms of CCK increased towards the distal jejunum.
Eberlein
G A
GA
University of Essen, Department of Gastroenterology, Federal Republic of Germany.
Eysselein
V E
VE
Goebell
H
H
D000595:Amino Acid Sequence; D000818:Animals; D002415:Cats; D002417:Cattle; D002766:Cholecystokinin / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D004386:Duodenum / Q000032:analysis; D006801:Humans; D007413:Intestinal Mucosa / Q000032:analysis; D007421:Intestine, Small / Q000032:analysis*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000032:analysis*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013552:Swine
D010446:Peptide Fragments; C038823:cholecystokinin 58; D002766:Cholecystokinin