Effect of excretory-secretory products of Giardia lamblia on glucose and phenylalanine transport in the small intestine of Swiss albino mice.
The transport of D-glucose and L-phenylalanine was measured in intestinal brush border membrane (BBM) vesicles treated with Excretory-secretory (ES) products of Giardia lamblia. Uptake was found to be significantly lower (P/0.01) in the treated vesicles than in the controls. Exposure of intestinal tissue to ES products resulted in net secretion (P/0.01) of Na+, C1- and 3-O-methyl-D-glucose. Both observations indicate that alterations in the absorptive functions of the intestine might be attributed to interaction of ES products with the BBM.
Samra
H K
HK
Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ganguly
N K
NK
Garg
U C
UC
Goyal
J
J
Mahajan
R C
RC
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D005872:Giardia; D005947:Glucose / Q000378:metabolism*; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism / Q000469:parasitology*; D051379:Mice; D008871:Microvilli / Q000187:drug effects / Q000378:metabolism; D010649:Phenylalanine / Q000378:metabolism*; D014118:Toxins, Biological / Q000302:isolation & purification / Q000494:pharmacology*
D014118:Toxins, Biological; D010649:Phenylalanine; D005947:Glucose