Nonsteroidal antiinflammatory agents. XVIII - Stereomeric optically active halogenophenyl-biphenylyl-hydroxypropionic acids.
The optically active stereomers of some 3-(fluoro-, chloro-, bromophenyl)-2-biphenylyl-3-hydroxypropionic acids were prepared and tested for antiinflammatory activity. Surprisingly, the four bromo-isomers were the most active ones, particularly in the threo configuration.
Varoli
L
L
Departimento di Scienze Farmaceutiche Università di Bologna, Italy.
Burnelli
S
S
Guarnieri
A
A
Ghedini
N
N
Scapini
G
G
Ferri
S
S
Cavicchini
E
E
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004487:Edema / Q000188:drug therapy; D010666:Phenylpropionates / Q000627:therapeutic use; D013237:Stereoisomerism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates