Mapping studies and expression of genes located on human chromosome 11, band q23.
Chromosome translocations and deletions may alter cellular proto-oncogenes and result in cellular changes that are important in the pathogenesis of malignancy. The region 11q23 is frequently involved in human malignancy. Utilizing a leukemic cell line with a reciprocal translocation involving 11q23 and somatic cell hybrids derived from this cell line, we analyzed five genes assigned to 11q23: NCAM, CD3D, CD3E, THY1, and ETS1. Our data showed no evidence of direct involvement of these genes in this leukemia but enabled a partial genetic map of this important region of the human genome to be constructed: 11cen--NCAM--CD3([G, D], E)--parallel--(ETS1, THY1)--11qter.
Savage
P D
PD
Department of Medicine, University of Minnesota Hospital and Clinic, Minneapolis 55455.
Jones
C
C
Silver
J
J
Geurts van Kessel
A H
AH
Gonzalez-Sarmiento
R
R
Palm
L
L
Hanson
C A
CA
Kersey
J H
JH
D000818:Animals; D015152:Blotting, Northern; D015139:Blotting, Southern; D002460:Cell Line; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D007938:Leukemia / Q000235:genetics
D005819:Genetic Markers