[Pyloroplasty and motile functions of the stomach and duodenum].
Mongrel dogs were prepared by attaching 2 and 1 silver needle bipolar electrodes on the gastric antrum and bulbus of the duodenum, respectively. Among the obtained active potential from these dogs at chronic stage, investigations were performed mainly on the discharge frequency of spikes, propagation pattern of electrical excitation, and relationship of the stomach and duodenum. In addition, barium was loaded as the stomach contents and extraction dynamics of the loads were observed radiologically. The following was these investigations concerning about the pyloroplasty and motile functions of the stomach and duodenum. Experimental methods 1) Electromyography and extraction dynamics of stomach contents were observed in no treated control dogs. 2) Heineke-Mikulicz type pyloroplasty, Finney type pyloroplasty, or pylorectomy was performed on the above described control dogs. Electromyographical comparison was made among the types of pyloroplasty. 3) Dogs subjected to selective vagolysis (SV), selective proximal vagotomy (SPV), or gastric transection (Tr) were divided into groups with and without pyloroplasty. Electromyography and extraction dynamics of stomach contents were observed in these groups of animals. Results 1) In the control dogs, the mean discharge frequency of spikes in the gastric antrum at fasting time was 4.86 cycle/minute. The spikes propagated to the pyloric side periodically. The discharge frequency of spikes was reduced by the load of stomach contents which took about 120 minutes to be extracted. 2) When the types of pyloroplasty were compared, smaller electromyographical changes were obtained in dogs subjected to Heineke-Mikulicz type pyloroplasty. 3) Pyloroplasty did not affect the discharge frequency of spikes at fasting time, whereas, high incidences of antiperistaltic propagation pattern of electrdcal excitation were observed in dogs subjected to SPV. 4) When stomach contents were loaded, drainage effects of pyloroplasty were suggested from the discharge frequency of spikes, propagation pattern of electrical excitation, and findings in extraction dynamics of the stomach contents. In the dogs subjected to SPV, pylorplasty induced no significant fluctuations in the discharge frequency of spikes. Dogs subjected to Tr showed no improvement in the frequent antiperistaltic propagation pattern of electrical excitement after the pyloroplasty. 5) By pyloroplasty, the frequency of simultaneous generation of spikes in the gastric antrum and duodenum was decreased in the SV and Tr groups, while it was increased in the SPV group.
Hashimura
C
C
Second Department of Surgery, Toho University, School of Medicine, Tokyo.
D000200:Action Potentials; D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000503:physiopathology*; D004576:Electromyography; D005743:Gastrectomy; D005769:Gastrointestinal Motility; D015391:Gastroplasty; D011708:Pylorus / Q000601:surgery; D013270:Stomach / Q000503:physiopathology*; D014628:Vagotomy