[Effect of adenosine-5'-O-(beta, gamma-dichloromethane)triphosphate on ATP-activated currents in sensory neurons in rats].
The action of beta,gamma-dihalogenmethane derivatives of ATP on ATP receptors has been studied in the sensory neurons of rats. beta,gamma-Dichloromethane-ATP and beta,gamma-dibromomethane-ATP are competitive blockers and beta,gamma-difluoromethane-ATP is a partial agonist of ATP receptors. At present, beta,gamma-dichloromethane-ATP is the most efficient of the known competitive blockers of these receptors (Ki = 2.10(-5) M). The data obtained confirm that beta- and gamma-phosphates of ATP play an important role in the activation of ATP receptors.
Marchenko
S M
SM
Obukhov
A G
AG
Volkova
T M
TM
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D066298:In Vitro Techniques; D009475:Neurons, Afferent / Q000187:drug effects* / Q000502:physiology; D051381:Rats
C056864:adenosine-5'-O-(beta,gamma-dichloromethane)triphosphate; D000255:Adenosine Triphosphate
Vliianie adenozin-5'-O-(beta, gamma-dikhlormetan)trifosfata na ATF-aktiviruimye toki v sensornykh neĭronakh krysy.