[Lymphokine-like activity in a culture of cells of the embryonal human brain and in the cerebrospinal fluid].
Factors functionally similar or even identical to interleukin-1 (IL-1) and interleukin-2 (IL-2) were found in the tissues of human embryo. These factors were found to be in reciprocal interrelationship. No activity of colony-stimulating factor was found in materials of cerebral origin. A high level of activity of the IL-2 was observed in the CSF of epileptic patients. The data obtained suggest a participation of lymphokines in the mechanisms of cellular cooperation in the brain as well as in proliferative processes underlying progressing diseases of the central nervous system.
Kiselev
O I
OI
Kambarova
D K
DK
Tsveibakh
A S
AS
Baloian
L N
LN
Ivanenko
A I
AI
D001921:Brain / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D002478:Cells, Cultured; D004827:Epilepsy / Q000134:cerebrospinal fluid / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000302:isolation & purification; D007376:Interleukin-2 / Q000302:isolation & purification; D008222:Lymphokines / Q000134:cerebrospinal fluid / Q000378:metabolism*
D007375:Interleukin-1; D007376:Interleukin-2; D008222:Lymphokines
Limfokino-podobnaia aktivnost' v kul'ture kletok émbrional'nogo mozgacheloveka i v spinnomozgovoĭ zhidkosti.