title: Urinary and faecal excretion of chrysene and chrysene metabolites by rats after oral, intraperitoneal, intratracheal or intrapulmonary application.
abstract: The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas chromatography/mass spectrometry. The metabolite profile was found to depend on the mode of excretion and on the route of administration. In all cases the oxidation of chrysene in the 1,2- or 3,4-position predominates, whereas oxidation in the 5,6-position (K-region) seems be a minor pathway.
authors.affiliation: Biochemical Institute for Environmental Carcinogens, Grosshansdorf, Federal Republic of Germany.
authors.forename: G
authors.initials: G
authors.lastname: Grimmer
authors.forename: H
authors.initials: H
authors.lastname: Brune
authors.forename: G
authors.initials: G
authors.lastname: Dettbarn
authors.forename: U
authors.initials: U
authors.lastname: Heinrich
authors.forename: J
authors.initials: J
authors.lastname: Jacob
authors.forename: E
authors.initials: E
authors.lastname: Mohtashamipur
authors.forename: K
authors.initials: K
authors.lastname: Norpoth
authors.forename: F
authors.initials: F
authors.lastname: Pott
authors.forename: R
authors.initials: R
authors.lastname: Wenzel-Hartung
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D002849:Chromatography, Gas; D002911:Chrysenes / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D005243:Feces / Q000032:analysis; D007274:Injections, Intraperitoneal; D007442:Intubation, Intratracheal; D008297:Male; D010616:Phenanthrenes / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D002911:Chrysenes; D010616:Phenanthrenes