title: Changes in the rat sleep-wake cycle produced by D,L-beta-(1-naphthyl)alanine, a tryptophan analog.
abstract: The effects of i.p. injections of D,L-beta-(1-naphthyl)alanine, a synthetic analog of tryptophan were tested on the rat sleep-waking cycle. Administration of 30, 60 and 120 mg/kg resulted in a significant increase in slow-wave sleep (SWS) and a decrease in paradoxical sleep (PS). These modifications were dose-dependent. These results were compared with those previously obtained with L-tryptophan and several analogs and discussed in relation with possible changes in central serotonergic activity.
authors.affiliation: INSERM U. 205, Department of Biological Chemistry, INSA, Villeurbanne, France.
authors.forename: C
authors.initials: C
authors.lastname: Rogemont
authors.forename: N
authors.initials: N
authors.lastname: Sarda
authors.forename: A
authors.initials: A
authors.lastname: Gharib
authors.forename: H
authors.initials: H
authors.lastname: Pacheco
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects*
chemical_list: C059031:1-naphthylalanine; D000409:Alanine