[Effects of cholecystokinin-octapeptide and tetragastrin on the contractile activities of the stomach, duodenum and papilla of Vater].
Effects of cholecystokinin-octapeptide (CCK-OP) and tetragastrin (TG) on the stomach, duodenum and papilla of Vater were examined using 13 adult dogs. The contractile activities of the stomach and duodenum were examined using the strain gage, and the manometric study of the papilla of Vater was also performed. CCK-OP increased the contractile activities of the stomach and duodenum, but at the same time the pressure of the papilla of Vater was decreased. TG increased the contractile activities of the stomach, but decreased that of the duodenum and the pressure of papilla of Vater. CCK-OP lowered the pressure of the common bile duct, and that fall corresponded with the disappearance of the phasic contraction of the papilla of Vater. We concluded that the contractile activity of the papilla of Vater was independent of the contractile activity of the duodenum, and the most effective drainage of the bile was achieved at the time of the disappearance of the phasic contraction of the papilla of Vater.
Yada
S
S
First Department of Surgery, School of Medicine, University of Tokushima.
Komi
N
N
D014670:Ampulla of Vater / Q000187:drug effects*; D000818:Animals; D001646:Bile / Q000378:metabolism; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000187:drug effects*; D005755:Gastrins / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D012844:Sincalide / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects*; D013758:Tetragastrin / Q000494:pharmacology*
D005755:Gastrins; D013758:Tetragastrin; D012844:Sincalide