[Synthesis, antisecretory, and anti-ulcer activity of new 5-arylidene-2-ureidoalkyl-3-pyridazinones].
By addition of methylisocyanate to 5-arylidene 2-aminoalkyl 3-pyridazinones a series of derivatives substituted in the 2-position by an ureidoalkyl moiety was obtained in good yields. Gastric antisecretory and anti-ulcer activities of these new compounds were evaluated. The influence of the substituents attached to the pyridazine ring was discussed.
Rubat
C
C
Laboratoire de Chimie Thérapeutique, Groupede Recherche en Pharmacochimie, Faculté de Pharmacie, Clermont-Ferrand, France.
Coudert
P
P
Couquelet
J
J
Bastide
P
P
Bastide
J
J
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D000897:Anti-Ulcer Agents; D011724:Pyridazines; D014508:Urea
Synthèse et activités antisécrétoire et anti-ulcéreuse de nouvelles arylidène-5 ureidoalkyl-2 pyridazinones-3.