B prolymphocytic leukemia cell lines: phenotype and response to B cell differentiation factor.
Three recently-derived cell lines of prolymphocytic leukemia origin were studied. The phenotype of the cells, analysed in terms of expression of immunoglobulin and other B cell maturation markers, indicates that the cells are mature B lymphocytes close to the plasma cell stage of differentiation. All three cell lines secrete IgM, and two of the three lines respond to B cell differentiation factor with an increased secretion of IgM.
Zola
H
H
Department of Clinical Immunology, Flinders Medical Centre, Bedford Park, South Australia.
Furness
V
V
Nikoloutsopoulos
A
A
Bradley
J
J
Melo
J V
JV
Catovsky
D
D
D000944:Antigens, Differentiation, B-Lymphocyte; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D002454:Cell Differentiation; D002460:Cell Line; D006680:HLA Antigens; D006801:Humans; D007136:Immunoglobulins; D015847:Interleukin-4; D007378:Interleukins / Q000494:pharmacology*; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000473:pathology; D010641:Phenotype; D014407:Tumor Cells, Cultured / Q000276:immunology / Q000473:pathology
D000944:Antigens, Differentiation, B-Lymphocyte; D006680:HLA Antigens; D007136:Immunoglobulins; D007378:Interleukins; D015847:Interleukin-4