Fluoxetine and pargyline on the nucleus raphe magnus inhibition of cat multireceptive dorsal horn neurones.
1. To determine whether serotonin (5-HT) is involved in the nucleus raphe magnus (NRM) inhibition of cat multireceptive dorsal horn neurones, the NRM inhibition was tested with drugs (fluoxetine and pargyline) that should enhance 5-HT synaptic activity. 2. Fluoxetine and pargyline systemically administered, individually or concurrently, decreased rather than increased the inhibition. 3. The results do not support the hypothesis that NRM stimulation-produced inhibition is mediated by 5-HT release.
Khanna
S
S
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Sinclair
J G
JG
D000818:Animals; D002415:Cats; D004347:Drug Interactions; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology*; D006358:Hot Temperature; D008297:Male; D009474:Neurons / Q000187:drug effects*; D010293:Pargyline / Q000494:pharmacology*; D011437:Propylamines / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000502:physiology*
D011437:Propylamines; D005473:Fluoxetine; D010293:Pargyline