Acute bromopride treatments: effects on general activity and inhibitory avoidance in rats.
Bromopride (BRO), a dopamine D2 blocker used in gastroenterology clinics, was tested acutely in rats for effects on general activity, measured in an open-field test, and on inhibitory avoidance behavior. Rats that received 2.5 and 5.0 mg/kg BRO showed lower locomotion and rearing frequencies than controls, and 5.0 mg/kg BRO blocked the inhibitory avoidance response. The data suggest that BRO may have neuroleptic effects.
Nasello
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AG
Departamento de Ciências Fisiológicas, Faculdade de Ciências Médicas da Santa Casa, São Paulo, Brasil.
Felicio
L F
LF
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains
C013855:bromopride; D008787:Metoclopramide