Chronic treatment with desmethylimipramine increases the oxytocin content in the hypothalamus and neurohypophysis of normal and pinealectomized male rats.
The effect of chronic treatment with desmethylimipramine (i.p., 10 mg/kg; twice daily over 5 days) on the content of oxytocin in the hypothalamus and neurohypophysis of normal and pinealectomized male rats has been investigated. Pinealectomy resulted in a decrease of oxytocin content in the hypothalamus and neurohypophysis. Treatment with desmethylimipramine (desipramine; DMI) was followed by a distinct increase of the oxytocin potency in the hypothalamus and neurohypophysis in both normal and pinealectomized rats. It may be supposed that chronic treatment with DMI inhibits the oxytocin release from neurohypophysis.
Juszczak
M
M
Department of Pathophysiology, School of Medicine, Lódź.
D000818:Animals; D001681:Biological Assay; D003891:Desipramine / Q000494:pharmacology*; D005260:Female; D007031:Hypothalamus / Q000032:analysis / Q000187:drug effects*; D008297:Male; D010121:Oxytocin / Q000032:analysis* / Q000378:metabolism; D010870:Pineal Gland / Q000502:physiology*; D010904:Pituitary Gland, Posterior / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D010121:Oxytocin; D003891:Desipramine