Effect of aminophylline aerosol on the bronchial response to ultrasonic mist of distilled water in asthmatic patients.
To ascertain whether inhaled aminophylline was effective in preventing the bronchial response induced by inhalating of an ultrasonic mist of distilled water (UMDW), we examined 8 asthmatic patients who had previously been shown to be reactive to this agent. Patients were given either 30 mg aminophylline or saline placebo aerosols followed by inhalation of 60 liters of UMDW; measurements of specific airway conductance (sGaw) were made before and after aminophylline or saline administration and after UMDW challenge. UMDW consistently induced a significant decrease in sGaw in all patients; however, in our subjects as a group, the degree of UMDW-induced bronchoconstriction was significantly less after premedication with aminophylline aerosol than after saline (p less than 0.01). Our results suggest that aminophylline is effective in preventing UMDW-induced bronchoconstriction; the possible relationships between bronchial response to UMDW and its modulation by inhaled aminophylline are discussed.
Fontana
G A
GA
Dipartimento di Fisiopatologia Clinica, Unità di Fisiopatologia Respiratoria, Firenze, Italia.
Hanson
P J
PJ
Cardellicchio
S
S
Cresci
F
F
Panuccio
P
P
D000280:Administration, Inhalation; D000328:Adult; D000336:Aerosols; D000628:Aminophylline / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D001985:Bronchial Provocation Tests; D005260:Female; D006801:Humans; D008297:Male
D000336:Aerosols; D000628:Aminophylline