title: Synthesis and antimicrobial activity of some N-monosubstituted 2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamides.
abstract: A short series of N-monosubstituted (aryl, aminoacyl, dipeptidyl)-2-(2-aminothiazol-4-yl)-(Z) -2-methoxyiminoacetamides was synthesized and tested for antimicrobial activity. A few members showed a somewhat interesting inhibitory action against Cryptococcus neoformans (MIC = 150 micrograms/ml).
authors.affiliation: Department of Pharmaceutical Science, University of Fermentation Chemistry, Faculty of Pharmacy, Bologna, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Garuti
authors.forename: A
authors.initials: A
authors.lastname: Ferranti
authors.forename: L
authors.initials: L
authors.lastname: Varoli
authors.forename: G
authors.initials: G
authors.lastname: Giovanninetti
authors.forename: P
authors.initials: P
authors.lastname: Brigidi
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D013844:Thiazoles