title: Interleukin-1 immunoreactive innervation of the human hypothalamus.
abstract: Interleukin-1 (IL-1) is a cytokine that mediates the acute phase reaction. Many of the actions of IL-1 involve direct effects on the central nervous system. However, IL-1 has not previously been identified as an intrinsic component within the brain, except in glial cells. An antiserum directed against human IL-1 beta was used to stain the human brain immunohistochemically for IL-1 beta-like immunoreactive neural elements. IL-1 beta-immunoreactive fibers were found innervating the key endocrine and autonomic cell groups that control the central components of the acute phase reaction. These results indicate that IL-1 may be an intrinsic neuromodulator in central nervous system pathways that mediate various metabolic functions of the acute phase reaction, including the body temperature changes that produce the febrile response.
authors.affiliation: Committee on Neurobiology, University of Chicago, IL 60637.
authors.forename: C D
authors.initials: CD
authors.lastname: Breder
authors.forename: C A
authors.initials: CA
authors.lastname: Dinarello
authors.forename: C B
authors.initials: CB
authors.lastname: Saper
mesh_terms: D006801:Humans; D007031:Hypothalamus / Q000032:analysis* / Q000033:anatomy & histology / Q000502:physiology; D007150:Immunohistochemistry; D007375:Interleukin-1 / Q000032:analysis* / Q000276:immunology; D009928:Organ Specificity
chemical_list: D007375:Interleukin-1