Effect of copper on activation of human T cells.
Immunomodulatory properties of copper were investigated. Human T cells, isolated from blood of healthy donors, were stimulated with phytohemagglutinin and cultured in vitro. It was found that copper sulphate depressed T cell proliferation when added in concentration of 10(-3) M. A slight increase in the T cell proliferation was shown in presence of 10(-5) M of copper ion while 10(-7)-10(-9) M had no effect on proliferation. Production of interleukin 2 by human T cells was depressed by all investigated doses of copper. The obtained results suggest the direct toxicity of copper on T cell activation.
Kucharz
E J
EJ
Department of Medicine, Medical College of Wisconsin, Milwaukee.
Sierakowski
S J
SJ
D002478:Cells, Cultured; D003300:Copper / Q000494:pharmacology*; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D007376:Interleukin-2; D003300:Copper