Experimental increase in brain HIPDM uptake by hypercapnia.
The 30-min brain uptake of [125I]HIPDM was measured in conscious rats--normocapnic (n = 8), hypercapnic (n = 12), and hyperoxic (n = 6). A mean 41.2% higher uptake was found in the brains of hypercapnic animals (p less than 0.01). In the three groups of rats, brain HIPDM uptake had a negative correlation with body weight (p less than 0.001) and a positive correlation with arterial pCO2 (p less than 0.01), when adjusted for body weight. These results indicate that HIPDM uptake with hypercapnia may be used as a provocative test to measure cerebral blood flow reserves.
Karatzas
N D
ND
Department of Radiology, University of Miami School of Medicine, FL 33101.
Sfakianakis
G N
GN
Pappas
D
D
Duncan
R
R
Heal
A
A
Serafini
A
A
Kung
H F
HF
D000818:Animals; D001835:Body Weight; D001921:Brain / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D006935:Hypercapnia / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014055:Tomography, Emission-Computed
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C036739:N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine