Acute poststreptococcal glomerulonephritis and sickle cell disease.
In this paper, we describe a case of acute poststreptococcal glomerulonephritis in a patient with sickle cell disease and review four other cases in the literature. Acute glomerulonephritis in patients with sickle disease frequently presents with anasarca, severe proteinuria, hypoproteinemia and normal complement. This presentation makes it difficult to differentiate acute glomerulonephritis from nephrotic syndrome associated with sickle cell disease. The prognosis of the two entities is extremely different; a renal biopsy may be needed to confirm the diagnosis.
Assar
R
R
Department of Pediatrics, University of Florida Health Science Center-Jacksonville.
Pitel
P A
PA
Lammert
N L
NL
Tolaymat
A
A
D000208:Acute Disease; D000755:Anemia, Sickle Cell / Q000150:complications*; D002648:Child; D003937:Diagnosis, Differential; D005921:Glomerulonephritis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000175:diagnosis; D013290:Streptococcal Infections / Q000150:complications*