Genetic control of C3 production by the S region of the mouse MHC.
The present paper reports evidence indicating that the level of the third complement component (C3) is regulated by the S region of the murine H-2 complex. In fact, using congenic strains of mice we demonstrate that mice with the k haplotype at the S region show high C3 levels, whereas mice with the d haplotype at the S region show low C3 levels.
Dieli
F
F
Institute of General Pathology, University of Palermo, Italy.
Lio
D
D
Sireci
G
G
Salerno
A
A
D000483:Alleles; D000818:Animals; D003176:Complement C3 / Q000096:biosynthesis / Q000235:genetics*; D005786:Gene Expression Regulation; D006183:H-2 Antigens / Q000235:genetics; D006239:Haplotypes; D006461:Hemolysis; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D003176:Complement C3; D006183:H-2 Antigens