title: Determinants of survival after forebrain ischemia in Mongolian gerbils.
abstract: Mongolian gerbils were exposed to 15 min of cerebral ischemia. Quantitative histology was used to establish neuronal damage in the CA1, CA2/3, and CA3 sectors of the hippocampus 2 weeks after the insult. Seven moribund animals were sacrificed earlier to examine whether there is a correlation between hippocampal damage and mortality. Surviving animals had a 86.6% loss of CA1 neurons. In the CA2/3 and CA3 sectors 62.7 and 72.6% of the neurons were preserved. Moribund animals had a further dramatic loss of nerve cells in these sectors, to 14.8 and 20.3%, respectively. The reduction of CA2/3 neurons and survival time were correlated. In addition, gerbils which would later become moribund were found to have a significant increase in plasma osmolarity from 319 to 342 mosm/liter and of hematocrit from 47.4 to 53.9 at day 4 after ischemia.
authors.affiliation: Institute for Surgical Research, Klinikum Grosshadern, Ludwig-Maximilians Universität München, FRG.
authors.forename: K
authors.initials: K
authors.lastname: Weber
authors.forename: A
authors.initials: A
authors.lastname: Baethmann
authors.forename: O
authors.initials: O
authors.lastname: Kempski
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002452:Cell Count; D006168:Guinea Pigs; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000401:mortality* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D013997:Time Factors
chemical_list: D001786:Blood Glucose