title: The effects of flosequinan and nifedipine on glucose tolerance in healthy volunteers.
abstract: The influence of flosequinan and nifedipine on glucose tolerance has been investigated in a placebo-controlled four-way crossover study in 12 healthy volunteers. There was no statistical difference between the glucose tolerance curves after placebo, a single dose of flosequinan, chronic treatment with flosequinan or nifedipine at steady state. Headache was more frequent in volunteers on flosequinan than after either nifedipine or placebo.
authors.affiliation: Department of Pharmacology, University of Birmingham, Medical School, Edgbaston, U.K.
authors.forename: H
authors.initials: H
authors.lastname: Lewis
authors.forename: M
authors.initials: M
authors.lastname: Kendall
authors.forename: J R
authors.initials: JR
authors.lastname: Bratty
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000009:adverse effects / Q000494:pharmacology*; D011804:Quinolines / Q000009:adverse effects / Q000494:pharmacology*; D013997:Time Factors; D014665:Vasodilator Agents / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D011804:Quinolines; D014665:Vasodilator Agents; C047316:flosequinan; D009543:Nifedipine