Stabilization of stannous pyrophosphate kits with gentisic acid.
We evaluated the ability of gentisic acid, an antioxidant, to stabilize stannous pyrophosphate (Sn:PPi) kits and extend the shelf-life of the kit after reconstitution. In vitro studies showed that gentisic acid (0.5 mg/mL) stabilized the stannous ion against oxidation by various levels of exogenous hydrogen peroxide. In patients who received stabilized Sn:PPi for in vivo red blood cell labelling, the left ventricle-to-background activity ratio was significantly higher than that in patients who received a standard formation of Sn:PPi. Gentisic acid is now used routinely in the Sn:PPi kit formulation in this institution.
Ballinger
J R
JR
Division of Nuclear Medicine, Ottawa Civic Hospital, Ontario, Canada.
Pygas
J
J
Gerson
B
B
Gulenchyn
K Y
KY
D004355:Drug Stability; D005841:Gentisates; D011122:Polyphosphates; D011933:Reagent Kits, Diagnostic; D014003:Tin Polyphosphates
D005841:Gentisates; D011122:Polyphosphates; D011933:Reagent Kits, Diagnostic; D014003:Tin Polyphosphates