Amnesic action of 2-deoxy-D-galactose is not related to alterations in the release of dopamine and noradrenaline.
2-deoxy-D-galactose, an inhibitor of glycoprotein fucosylation, did neither affect the K+-stimulated release of noradrenaline from rat striatal slices nor that of dopamine from striatal synaptosomes. The results are discussed in the light of an amnesic action of the deoxy-sugar in animal learning experiments.
Schröder
H
H
Institute of Pharmacology and Toxicology, Medical Academy Magdeburg, DDR.
Jork
R
R
Matthies
H
H
D000647:Amnesia / Q000139:chemically induced; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005643:Fucose / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D005643:Fucose; D011188:Potassium; D004298:Dopamine; D009638:Norepinephrine