Enhanced allograft survival in H-2 compatible cyclosporine-treated mice.
Skin allograft survival time has been prolonged in a variety of animal and human studies. Burn injury, histocompatibility matching, and cyclosporine administration each independently have been shown to increase skin allograft survival times. A mouse model was developed to study these relationships. Histocompatibility matching of mouse H-2 I showed a trend toward skin allograft prolongation when comparing nonburned and burned animals. When there was complete histocompatibility of mouse H-2 and H-4 allograft survival time was significantly prolonged. Cyclosporine administration to the optimally matched donor/recipient combination further enhanced allograft survival. This study demonstrated that histocompatibility matching for the entire H-2 locus correlated with prolonged allograft survival. Optimal histocompatibility and cyclosporine administration further enhanced skin allograft survival in burned mice.
Krob
M J
MJ
Department of Surgery, Mercy Hospital of Pittsburgh, PA 15219.
Shelby
J
J
D000818:Animals; D002056:Burns / Q000601:surgery*; D003524:Cyclosporins / Q000627:therapeutic use*; D006082:Graft Enhancement, Immunologic / Q000379:methods*; D006085:Graft Survival / Q000187:drug effects; D006649:Histocompatibility Antigens / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D003524:Cyclosporins; D006649:Histocompatibility Antigens