Effect of 5-hydroxytryptamine on the rate of cerebrospinal fluid production in rabbit.
Infusion of 5-hydroxytryptamine in mock cerebrospinal fluid of rabbits lowered cerebrospinal fluid production dose-dependently by nearly 30%. The effect was amplified in the presence of the monoamine oxidase inhibitor, nialamide. The 5-hydroxytryptamine-induced inhibition was partly counteracted by ketanserin, and further addition of practolol completely blocked the reduction in cerebrospinal fluid formation, suggesting that both 5-hydroxytryptamine receptors and beta 1-adrenergic receptors were involved in the response mediated by both the secretory epithelium and the vascular bed of the plexus.
Lindvall-Axelsson
M
M
Department of Medical Cell Research, University of Lund, Sweden.
Mathew
C
C
Nilsson
C
C
Owman
C
C
D000818:Animals; D002555:Cerebrospinal Fluid / Q000187:drug effects / Q000502:physiology*; D002831:Choroid Plexus / Q000378:metabolism; D004357:Drug Synergism; D005260:Female; D007201:Indicator Dilution Techniques; D007276:Injections, Intraventricular; D007444:Inulin; D008297:Male; D009526:Nialamide / Q000494:pharmacology; D010477:Perfusion; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D007444:Inulin; D009526:Nialamide