Inhibition of long-term potentiation of the hippocampal CA1 EPSP by a negative cooperativity.
Tetanization of commissural-CA1 input to the apical dendrites of the dorsal hippocampal CA1 area was found to produce a marked long-term potentiation of the field EPSP. Whereas by concurrent tetanization of the commissural pathway and medial septo-CA1 input, this potentiation was significantly reduced. Thus a negative cooperativity in LTP induction was revealed.
Xie
X P
XP
Institute of Basic Medical Sciences, Beijing, People's Republic of China.
D000818:Animals; D003712:Dendrites / Q000502:physiology; D004558:Electric Stimulation; D005071:Evoked Potentials; D006624:Hippocampus / Q000502:physiology*; D011712:Pyramidal Tracts / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013238:Stereotaxic Techniques