Immunoglobulin A subclass-containing plasma cells in the jejunum in primary IgA nephropathy and in Henoch-Schönlein purpura.
We studied the distribution of IgA1- and IgA2-containing plasma cells in the jejunum of 5 patients with primary IgA nephropathy and of 2 patients with Henoch-Schönlein purpura. The percentage of IgA-containing cells (62.3 +/- 4.6) was below the level found in normal (79.4 +/- 5.1) (p less than 0.001). The percentage of IgA1-containing plasma cells relative to the total IgA-containing cells was too low in 2, normal in 3 and too high in 2 subjects (mean percentage 68.1 +/- 9.6; normal 69.0 +/- 3.8). Our data do not support an increased production of IgA1 in the jejunal mucosa of patients with primary IgA nephropathy or with Henoch-Schönlein purpura.
Hené
R J
RJ
Department of Nephrology and Hypertension, University Hospital, Utrecht, The Netherlands.
Schuurman
H J
HJ
Kater
L
L
D000293:Adolescent; D000328:Adult; D005260:Female; D005455:Fluorescent Antibody Technique; D005922:Glomerulonephritis, IGA / Q000276:immunology*; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology*; D007070:Immunoglobulin A / Q000378:metabolism*; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007413:Intestinal Mucosa / Q000276:immunology; D007583:Jejunum / Q000276:immunology*; D008297:Male; D010950:Plasma Cells / Q000276:immunology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M