title: A comparative study of aztreonam and procaine penicillin/probenecid in the treatment of uncomplicated gonorrhoea.
abstract: 236 patients with uncomplicated gonorrhoea were randomly allocated to receive either aztreonam or procaine penicillin plus probenecid. 115 patients (50 men and 65 women) with uncomplicated gonorrhoea were treated with 1 g aztreonam as a single intramuscular injection. The success rate among those who attended at least one follow up examination after treatment was 99%. The antibiotic was well tolerated and there were no side effects. The observed minimum inhibitory concentrations (MICs) of aztreonam in vitro were very much lower than obtainable serum concentrations. The penicillin treated patients who were evaluable showed a failure rate of 12.8%. We conclude that aztreonam is effective against Neisseria gonorrhoeae, including penicillinase-producing strains, both in vivo and in vitro.
authors.affiliation: Department of Genito-Urinary Medicine, St. Luke's Hospital, Bradford, West Yorkshire, England.
authors.forename: K C
authors.initials: KC
authors.lastname: Mohanty
authors.forename: R
authors.initials: R
authors.lastname: Deighton Fimls
authors.forename: R G
authors.initials: RG
authors.lastname: Strachan
mesh_terms: D001398:Aztreonam / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000627:therapeutic use*; D010402:Penicillin G Procaine / Q000008:administration & dosage / Q000627:therapeutic use*; D010405:Penicillinase / Q000096:biosynthesis; D011339:Probenecid / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation
chemical_list: D010402:Penicillin G Procaine; D010405:Penicillinase; D001398:Aztreonam; D011339:Probenecid; D010400:Penicillin G