title: Insulin-dependent changes in lysosomal cathepsin D activity in rat liver, kidney, brain and heart.
abstract: Streptozotocin-induced diabetes resulted in a decrease in the cathepsin D activity (free and total) in rat liver, kidney, brain and heart with a concomitant increase in tissue protein content and amino acids pool size. Treatment with insulin brought about the restoration of the cathepsin D activity to normal or greater than normal levels; tissue protein content and amino acids pool size also returned to normal values.
authors.affiliation: Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
authors.forename: M A
authors.initials: MA
authors.lastname: Nerurkar
authors.forename: J G
authors.initials: JG
authors.lastname: Satav
authors.forename: S S
authors.initials: SS
authors.lastname: Katyare
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology; D002402:Cathepsin D / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000201:enzymology*; D007328:Insulin / Q000494:pharmacology* / Q000627:therapeutic use; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000596:Amino Acids; D007328:Insulin; D002402:Cathepsin D