Autoantibodies to the core proteins of hnRNPs.
A novel autoantibody reacting the the core polypeptides of hnRNP particles has been detected in the serum of a patient with systemic lupus erythematosus (SLE) and Sjögren's syndrome manifestations. Immunoblot analysis, using either rat liver or HeLa nuclear extracts as the antigen source, demonstrated that the autoantibody interacts with a specific subgroup of the core polypeptides of hnRNP particles, namely A2, B1 and B2, but not with A1, C1 and C2.
Dangli
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A
Biological Research Center, National Hellenic Research Foundation, Athens, Greece.
Guialis
A
A
Vretou
E
E
Sekeris
C E
CE
D000818:Animals; D001323:Autoantibodies / Q000302:isolation & purification*; D002467:Cell Nucleus / Q000276:immunology*; D002846:Chromatography, Affinity; D005455:Fluorescent Antibody Technique; D006367:HeLa Cells / Q000276:immunology; D000076245:Heterogeneous Nuclear Ribonucleoprotein A1; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; D034482:Heterogeneous-Nuclear Ribonucleoprotein Group C; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D006801:Humans; D008099:Liver / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D051381:Rats; D012261:Ribonucleoproteins / Q000276:immunology*; D012859:Sjogren's Syndrome / Q000276:immunology
D001323:Autoantibodies; C439788:C1 HNRNP; C503635:HNRNPC protein, human; D000076245:Heterogeneous Nuclear Ribonucleoprotein A1; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; D034482:Heterogeneous-Nuclear Ribonucleoprotein Group C; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D012261:Ribonucleoproteins; C439768:hnRNP A2