title: Population pharmacokinetics of gentamicin in neonates.
abstract: The influence of a number of clinical characteristics on the population pharmacokinetics of gentamicin were examined using routine drug-monitoring data from a group of 113 neonates. The data were analyzed using the programme NONMEM. Clearance was 0.053 litres.h-1.kg-1 and was reduced in neonates with postconceptional age less than or equal to 34 weeks (X 0.83) and 5-min Apgar score less than 7 (X 0.82). Volume of distribution was 0.47 litres.kg-1. These population mean parameter estimates were used to generate dosage regimens to achieve concentrations within the therapeutic range.
authors.affiliation: Department of Materia Medica, University of Glasgow, UK.
authors.forename: A H
authors.initials: AH
authors.lastname: Thomson
authors.forename: S
authors.initials: S
authors.lastname: Way
authors.forename: S M
authors.initials: SM
authors.lastname: Bryson
authors.forename: E M
authors.initials: EM
authors.lastname: McGovern
authors.forename: A W
authors.initials: AW
authors.lastname: Kelman
authors.forename: B
authors.initials: B
authors.lastname: Whiting
mesh_terms: D000375:Aging / Q000378:metabolism; D001034:Apgar Score; D005260:Female; D005839:Gentamicins / Q000493:pharmacokinetics*; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D008297:Male
chemical_list: D005839:Gentamicins