title: Expression of class II MHC gene products by macrophages in human uteroplacental tissue.
abstract: The expression of class II MHC determinants by fetal and maternal macrophages in human uteroplacental tissues was examined with monoclonal antibodies directed against HLA-DR, DP and DQ antigens. Maternal macrophages in early and full-term pregnancy decidua were HLA-DR positive, and a substantial proportion also expressed DP and DQ antigens. Fetal macrophages in chorionic villous stroma in first-trimester pregnancy were rarely HLA-DR positive, and DQ and DP antigens were never expressed. In term placental tissues, groups of villous stromal macrophages were HLA-DR positive, as were fetal macrophages within amniotic mesenchyme. In contrast, DP and DQ antigens were detected on a small minority of fetal macrophages in term placental tissues. DP and DQ antigens were not detected in the absence of DR antigens.
authors.affiliation: Department of Pathology, University of Leeds, U.K.
authors.forename: J N
authors.initials: JN
authors.lastname: Bulmer
authors.forename: L
authors.initials: L
authors.lastname: Morrison
authors.forename: J C
authors.initials: JC
authors.lastname: Smith
mesh_terms: D002824:Chorionic Villi / Q000276:immunology; D003656:Decidua / Q000276:immunology; D005321:Extraembryonic Membranes / Q000276:immunology; D005260:Female; D005333:Fetus / Q000276:immunology*; D006681:HLA-D Antigens / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D008264:Macrophages / Q000276:immunology*; D010920:Placenta / Q000276:immunology*; D011247:Pregnancy / Q000276:immunology*; D011261:Pregnancy Trimester, First; D011263:Pregnancy Trimester, Third
chemical_list: D006681:HLA-D Antigens