Poor prognosis of acute lymphoblastic leukemia with translocation (1;19) in childhood: potential interest of allogeneic bone marrow transplantation.
We report a new case of childhood acute lymphoblastic leukemia with translocation (1;19). At the time of diagnosis, the only adverse prognosis factor was the existence of this translocation. Under conventional chemotherapy, the girl experienced early marrow relapse (duration of first remission was 2 months). She received allogeneic bone marrow transplantation during the second remission and is alive in continuous complete remission 20 months after transplant. Several earlier reports have suggested that children with the (1;19) have a poor prognosis; If this poor response to conventional therapy is confirmed, an allogeneic bone marrow transplantation should be considered during the first remission.
Vagner-Capodano
A M
AM
Laboratoire de Génétique, Faculté de Médecine, Marseille, France.
Michel
G
G
Maraninchi
D
D
Tubiana
N
N
Gouzien
M
M
Perrimond
H
H
Carcassonne
Y
Y
D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000628:therapy; D011379:Prognosis; D014178:Translocation, Genetic