title: cDNA clones coding for the structural subunit of a chicken brain nicotinic acetylcholine receptor.
abstract: Nicotinic acetylcholine receptors (AChRs) immunoaffinity-purified from brains are composed of only two kinds of subunits rather than the four kinds present in muscle-type AChRs. Here we report the N-terminal protein sequences of the structural subunits of AChRs from rat and chicken brains and the cloning of full-length cDNAs for the chicken brain AChR structural subunit. Previously, the N-terminal amino acid sequence of the ACh-binding subunit of AChR immunoaffinity-purified from rat brain was shown to correspond to the cDNA alpha 4. Thus, cDNA sequences are now known for both of the subunits that form one AChR subtype in vivo.
authors.affiliation: Receptor Biology Laboratory, Salk Institute for Biological Studies, San Diego, California 92138.
authors.forename: R
authors.initials: R
authors.lastname: Schoepfer
authors.forename: P
authors.initials: P
authors.lastname: Whiting
authors.forename: F
authors.initials: F
authors.lastname: Esch
authors.forename: R
authors.initials: R
authors.lastname: Blacher
authors.forename: S
authors.initials: S
authors.lastname: Shimasaki
authors.forename: J
authors.initials: J
authors.lastname: Lindstrom
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000032:analysis*; D008969:Molecular Sequence Data; D011978:Receptors, Nicotinic / Q000032:analysis* / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
chemical_list: D011978:Receptors, Nicotinic; D004247:DNA