[Lysosome proteinases and protein turnover in the liver, spleen and thymus of rats undergoing antigenic stimulation and fasting].
Antigenic stimulation (AS) inhibited cathepsin A and D activation in the liver induced by fasting. AS after short-term fasting (4 days) induced the activation increase in the most of lysosomal proteinases by 20-80% in the spleen and thymus, while AS of animals, upon 6- and 8-day fasting depressed the activation of all the investigated lysosomal hydrolases (cathepsin A, B, C, D and arylsulphatases A and B) and decreased the total protein half-life. The revealed peculiarities in the lysosomal proteolytic system function and intensified protein turnover in lymphoid organs may reflect the general reaction of the organism, directed towards the maintenance of immunological homeostasis and, in particular, towards antibody production.
Vasil'ev
A V
AV
Konovalova
L S
LS
Pletsityĭ
K D
KD
Davydova
T V
TV
Tutel'ian
V A
VA
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology*; D010450:Endopeptidases / Q000378:metabolism*; D005215:Fasting; D006207:Half-Life; D007114:Immunization; D008099:Liver / Q000276:immunology / Q000378:metabolism*; D008247:Lysosomes / Q000201:enzymology* / Q000276:immunology; D008297:Male; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology / Q000378:metabolism*; D013950:Thymus Gland / Q000276:immunology / Q000378:metabolism*; D013997:Time Factors
D000941:Antigens; D011506:Proteins; D010450:Endopeptidases
Proteinazy lizosom i obnovlenie belka v pecheni, selezenke i timuse krys pri antigennoĭ stimuliatsii i golodanii.