title: Successful transplantation of 100 untransfused cyclosporine-treated primary recipients of cadaveric renal allografts.
abstract: This report examines the effect of pretransplant (pre-Tx) blood transfusions (BT) on the patient and graft survival results of 320 cyclosporine (CsA) and prednisone (Pred)-treated primary (1 degree) recipients of cadaveric (CAD) donor renal allografts. The 320 CsA-Pred treated 1 degree-CAD recipients included 100 pre-Tx untransfused (O-BT) and 220 transfused patients. The overall patient survival at 12, 24, and 36 months post-Tx were 94%, 94%, and 93%, respectively. There were no differences observed in graft survivals at 12, 24, or 36 months post-Tx whether patients received 0, 1-4, greater than or equal to 5-10 or greater than 10 pre-Tx BTs. A mean serum creatinine of 1.9 +/- 0.7 mg/dl was comparable among all BT groups at 12, 24, and 36 months post-Tx. The frequency of rejection episodes--namely, 37% for O-BT and 36% for greater than O-BT were identical. High-risk patients (greater than 45 years of age, diabetics, or blacks) were comparably distributed in O-BT and greater than O-BT groups and did not impact on the data. Similarly, increasing panel-reactive antibodies (PRA), associated with increasing numbers of pre-Tx BTs, did not influence the data. When HLA A, B, and DR matching results were combined with the BT groupings no differences were observed in patient or graft survivals. Poorly matched and untransfused recipients did as well as well-matched, transfused recipients. These findings suggest that CsA-Pred immunosuppressive therapy allows for successful 1 degree-CAD renal allograft transplantation without the need for pretransplant blood transfusion conditioning or matching of donor HLA A, B, and DR antigens to recipients.
authors.affiliation: Department of Surgery, University of Texas Medical School, Houston 77030.
authors.forename: R H
authors.initials: RH
authors.lastname: Kerman
authors.forename: C T
authors.initials: CT
authors.lastname: Van Buren
authors.forename: R M
authors.initials: RM
authors.lastname: Lewis
authors.forename: B D
authors.initials: BD
authors.lastname: Kahan
mesh_terms: D001803:Blood Transfusion; D002102:Cadaver; D003524:Cyclosporins / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006082:Graft Enhancement, Immunologic; D006085:Graft Survival; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D016030:Kidney Transplantation; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D011300:Preoperative Care; D014184:Transplantation, Homologous
chemical_list: D003524:Cyclosporins; D006680:HLA Antigens; D011241:Prednisone