Effect of fluphenazine on the footshock-induced opioid analgesia and leu-enkephalin concentration in the rat brain.
The effect of post-shock injection of 5 mg/kg fluphenazine on stress-induced analgesia (tail immersion test) and leu-enkephalin content in discrete brain areas (radioimmunoassay) was studied in male Wistar rats. The stress-induced analgesia, which was naloxone-reversible, was attenuated and shortened by fluphenazine, the drug also antagonized the stress-induced fall in hypothalamic leu-enkephalin content. Fluphenazine alone depressed the leu-enkephalin content in the medulla oblongata, and this effect was less marked in rats subjected to footshock.
Kowalski
J
J
Department of Clinical Pharmacology, Silesian Medical Academy, Katowice, Poland.
Huzarska
M
M
Jasiński
R
R
D000698:Analgesia; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D004597:Electroshock; D004743:Enkephalin, Leucine / Q000378:metabolism*; D005476:Fluphenazine / Q000494:pharmacology*; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000378:metabolism; D009270:Naloxone / Q000494:pharmacology; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000378:metabolism; D013997:Time Factors
D009270:Naloxone; D004743:Enkephalin, Leucine; D005476:Fluphenazine