title: The design and synthesis of mimetics of peptide beta-turns.
abstract: The synthesis of an 11 membered ring bis-lactam, a system which is designed as a conformationally restricted mimetic of type I and type II beta-turns is described. Computer assisted molecular modeling was used to compare the predicted low energy conformers of the turn mimetic with idealized type I and type II turn structures. Initial computational analysis indicates that the basic ring structure will provide an excellent foundation for the development of a varieity of beta-turn mimetics.
authors.affiliation: University of Illinois, Department of Chemistry, Chicago 60680.
authors.forename: M
authors.initials: M
authors.lastname: Kahn
authors.forename: S
authors.initials: S
authors.lastname: Wilke
authors.forename: B
authors.initials: B
authors.lastname: Chen
authors.forename: K
authors.initials: K
authors.lastname: Fujita
authors.forename: Y H
authors.initials: YH
authors.lastname: Lee
authors.forename: M E
authors.initials: ME
authors.lastname: Johnson
mesh_terms: D015198:Designer Drugs; D010455:Peptides / Q000138:chemical synthesis; D011487:Protein Conformation; D047090:beta-Lactams
chemical_list: D015198:Designer Drugs; D010455:Peptides; D047090:beta-Lactams