title: Activated Fc alpha T cells in Crohn's disease are involved in regulation of IgA.
abstract: Activated peripheral T cells (APT) of patients with Crohn's disease (CD) have been analysed for the expression of IgA-Fc receptors and for competence of IgA regulation. It was found that within the subset of APT an increased number of cells express binding sites for IgA (IgA-Fc), that was not found in other diseases with elevated numbers of APT. Moreover the number of IgA-Fc receptor expressing T cells was found to be increased in the inflamed mucosa too. Cocultures with autologous B cells revealed that isolated IgA-Fc receptor bearing T cells of patients with CD suppress IgA secretion. These data support the hypothesis that APT are involved in the immunopathogenesis of CD.
authors.affiliation: Med. Dept. Univ., Hamburg, FRG.
authors.forename: A
authors.initials: A
authors.lastname: Raedler
authors.forename: S
authors.initials: S
authors.lastname: Schreiber
authors.forename: K H
authors.initials: KH
authors.lastname: Schulz
authors.forename: S
authors.initials: S
authors.lastname: Peters
authors.forename: H
authors.initials: H
authors.lastname: Greten
authors.forename: H G
authors.initials: HG
authors.lastname: Thiele
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D003424:Crohn Disease / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D011961:Receptors, Fc / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; C036832:Fc(alpha) receptor; D007070:Immunoglobulin A; D011961:Receptors, Fc