The effect of flunarizine and nimodipine on rotatory evoked potentials in rabbit.
Rotatory evoked potentials were recorded in 6 normal albino rabbits before and after administration of flunarizine and nimodipine. Latencies of REP were unchanged by the Ca-antagonists whereas their amplitudes showed some characteristic alterations. There was a significant lowering of amplitude in those peaks which had previously been shown to be of vestibular origin. The peaks that reflect somatosensory activity were amplified by the drugs. Flunarizine showed a more marked effect on the vestibular part of the response than nimodipine. A selective action of Ca-antagonists on brainstem nuclei is suspected.
Zünkeler
B
B
Department of Neurology, University of Münster, West Germany.
Hofferberth
B
B
D000818:Animals; D001933:Brain Stem / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects; D007758:Ear, Inner / Q000601:surgery; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D005444:Flunarizine / Q000494:pharmacology*; D009553:Nimodipine / Q000494:pharmacology*; D011817:Rabbits; D011930:Reaction Time / Q000187:drug effects; D014722:Vestibule, Labyrinth / Q000187:drug effects
D009553:Nimodipine; D005444:Flunarizine