[Multicenter skin tumor of the interdigitating dendritic cell].
This report concerns a multicentric skin tumor of dendritic cells. Skin-colored to reddish-brown papules and nodules erupted on the right arm of a 68-year-old man and, during the following years, spread to the upper extremities, shoulders, legs and face. Immunohistochemically the large, histiocyte-like tumor cells are Leu-6 (CD1), Leu-3a (CD4), HLA-DR/DQ and S-100 protein positive, but on thorough ultrastructural investigation were found to lack Birbeck granules. Thus, this disease represents a skin tumor of the interdigitating dendritic cell, an accessory cell which, in this case, was associated with a high content of T-lymphocytes within the cutaneous cellular infiltrate. The clinical course is characterized by periodic progression with intermittent, spontaneous regression. During a 7-year follow-up it was not possible to ascertain involvement of either lymph nodes or internal organs.
Weber
L
L
Abteilung Dermatologie, Universität Ulm.
Hesse
G
G
Feller
A C
AC
Rodermund
O E
OE
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D003713:Dendritic Cells / Q000473:pathology*; D054747:Histiocytic Sarcoma / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
D014408:Biomarkers, Tumor
Multizentrischer Hauttumor der interdigitierenden dendritischen Zelle.