Effect of normobaric hyperoxia on airways of normal subjects.
Airway responsiveness to inhaled cholinergic agonist during the early stage of pulmonary O2 toxicity was examined to determine whether normobaric hyperoxia alters airway function. Eight healthy nonsmoking males with moderate base-line methacholine responsiveness breathed normobaric O2 (greater than or equal to 95%) over 12 h and on another occasion breathed air in an identical protocol. Vital capacity, expiratory flow, airway responsiveness to methacholine, and respiratory symptoms were measured at 0, 4, 8, and 12 h while subjects breathed O2 and 12 h afterwards. After 12 h, forced vital capacity was significantly decreased with O2 breathing but not with air breathing. At 4, 8, or 12 h of exposure and 12 h after exposure, there was no difference in methacholine sensitivity or reactivity between O2 and air-exposure trials. The earliest manifestations of pulmonary normobaric O2 toxicity in normal adults include diminished vital capacity and the onset of respiratory symptoms, but early O2 toxicity does not produce altered responsiveness to inhaled methacholine.
Beckett
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WS
John B. Pierce Foundation Laboratories, Yale University School of Medicine, New Haven, Connecticut 06510.
Wong
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ND
D000328:Adult; D005541:Forced Expiratory Volume; D006400:Hematocrit; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds; D010100:Oxygen / Q000633:toxicity*; D012016:Reference Values; D013997:Time Factors; D014797:Vital Capacity / Q000187:drug effects
D008688:Methacholine Compounds; D016210:Methacholine Chloride; D010100:Oxygen