Cure of mucormycosis in a renal transplant patient receiving ciclosporin with maintenance of immunosuppression.
Rhinocerebral mucormycosis in renal transplant recipients is associated with high mortality and allograft rejection. We report the first case of successful treatment of mucormycosis in a renal transplant recipient receiving ciclosporin and corticosteroids with maintenance of renal function. It is postulated that the relatively specific immunosuppression caused by ciclosporin, together with aggressive medical and surgical intervention, may enable the cure of this life-threatening fungal infection without loss of donor kidney function.
Kaplan
A H
AH
Department of Internal Medicine, University of North Carolina School of Medicine, Chapel Hill.
Poza-Juncal
E
E
Shapiro
R
R
Stapleton
J T
JT
D000328:Adult; D003131:Combined Modality Therapy; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D009091:Mucormycosis / Q000209:etiology / Q000628:therapy*; D009668:Nose Diseases / Q000209:etiology / Q000628:therapy*; D010254:Paranasal Sinus Diseases / Q000209:etiology / Q000628:therapy*; D012233:Rhizopus
D003524:Cyclosporins