title: A new syndrome: angiotensin-converting enzyme dysfunction syndrome: differential diagnosis and pathogenesis--case reports.
abstract: The authors previously reported a new syndrome, angiotensin-converting enzyme dysfunction syndrome (ACEDS), which is clinically characterized by mild systemic hypertension, a hypokalemic alkalosis, and hyperreninism with a high concentration of angiotensin-I (ANG-I), a normal angiotensin-II (ANG-II) value, and a normal aldosterone level. In the present study, they investigated the diagnosis and differentiation of diseases concomitant with hyperreninism, such as ACEDS, Bartter's syndrome, familial periodic paralysis, and renovascular hypertension treated with captopril for two months, and discussed the pathogenesis of ACEDS.
authors.affiliation: Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Umeki
authors.forename: A
authors.initials: A
authors.lastname: Terao
authors.forename: T
authors.initials: T
authors.lastname: Sawayama
mesh_terms: D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood; D000803:Angiotensin I / Q000097:blood*; D000804:Angiotensin II / Q000097:blood; D001477:Bartter Syndrome / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood*; D006978:Hypertension, Renovascular / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010245:Paralyses, Familial Periodic / Q000097:blood* / Q000188:drug therapy; D010243:Paralysis / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D010507:Periodicity; D011188:Potassium / Q000627:therapeutic use; D012083:Renin / Q000097:blood*; D013577:Syndrome
chemical_list: D000804:Angiotensin II; D000450:Aldosterone; D000803:Angiotensin I; D012083:Renin; D011188:Potassium