Acute lymphoblastic leukemia in adult identical twins.
The development of acute lymphoblastic leukemia (c-ALL) in identical twins is reported. The first born had ALL in 1982 and bone marrow transplantation was performed in first complete remission (CR) from his healthy twin-brother the same year. The bone marrow donor developed ALL in 1985; he received an autologous bone marrow transplantation in first CR in 1986. Unfortunately, both patients relapsed in 1986. Cytogenetic studies of the first born revealed multiple chromosomal abnormalities and a marker chromosome whereas the second patient had a Philadelphia chromosome. Genetic reasons or exposure to leukemogenic agents may be responsible for the onset of these leukemias.
Hecht
T
T
Medizinische Universitätsklinik Freiburg, Abteilung für Hämatologie und Onkologie, Federal Republic of Germany.
Henke
M
M
Schempp
W
W
Bross
K J
KJ
Löhr
G W
GW
D000328:Adult; D016026:Bone Marrow Transplantation; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D004200:Diseases in Twins; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D008297:Male; D010677:Philadelphia Chromosome; D012008:Recurrence; D014427:Twins; D014430:Twins, Monozygotic
D005819:Genetic Markers