[Stimulation with quaterin of DNA replication and repair].
Quaterine [3-(2,2,3-trimethylhydrasinium)propionate] possessing a wide spectrum of physiological activity has been studied for its effect on the intensity of replicative and reparative DNA synthesis in different rat tissues (liver, thymus, heart, intestine mucosa and spleen) in order to investigate molecular mechanisms of its action. It is shown that the pronounced stimulation of DNA synthesis in all tissues, as a rule, takes place 1-6h after quaterine administration in doses of 25 and 100 mg/kg. The estimation of the given compound effect on DNA synthesis after its multiple administration to animals (for 5, 10, 15 days in a dose of 100 mg/kg) permits supposing that 3-(2,2,2-trimethylhydrasinium)propionate is able of providing either stable proliferation of cells (thymus, spleen) or their hyperplasia and polyploidization (heart, liver). The data obtained make it possible to explain (to some extent) quaterine ability to activate immune responses, to stimulate healing of wounds and burns.
Blium
Ia B
IaB
Kalvin'sh
I Ia
IIa
Kucherenko
N E
NE
Lukevits
E Ia
EIa
D000818:Animals; D004260:DNA Repair / Q000187:drug effects*; D004261:DNA Replication / Q000187:drug effects*; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D014018:Tissue Distribution
D008763:Methylhydrazines; C050147:3-(2,2,2-trimethylhydrazine)propionate
Stimuliatsiia kvaterinom intensivnosti replikativnogo i reparativnogo sinteza DNK.