Newer antiarrhythmic drugs.
The effective management of cardiac arrhythmias remains a major challenge in cardiovascular therapeutics. The management of arrhythmias encompasses a wide spectrum of supraventricular and ventricular tachyarrhythmias occurring in patients with various cardiac diagnoses and different degrees of myocardial dysfunction. A number of the newer antiarrhythmic drugs that have either recently been released or appear promising are reviewed in this article. Drugs are described with respect to their basic pharmacology, electrophysiologic actions, pharmacokinetics and metabolism, hemodynamics, antiarrhythmic effects, side effects, interactions, indications, and dosage.
Michelson
E L
EL
Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.
Dreifus
L S
LS
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000145:classification / Q000493:pharmacokinetics / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D004594:Electrophysiology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans
D000889:Anti-Arrhythmia Agents