title: Azimexone and cysteine hydrazide in the treatment of allergic encephalomyelitis.
abstract: In the course of allergic encephalomyelitis (EAE) in chickens, azimexone suppressed the production of the specific IgM immunoglobulins. Moreover, it decreased the level of haptoglobin and sialic acid but stimulated the activity of antitrypsin. It was also observed to reduce the production of the plasmatic cells in the spleen. L-cysteine hydrazide hydrochloride decreased the level of sialic acid in EAE; intensified the activity of trypsin inhibitor and exerted no effect upon the level of antimyelin antibodies.
authors.affiliation: Department of Experimental Therapy, Polish Academy of Sciences, Wrocław.
authors.forename: B
authors.initials: B
authors.lastname: Błaszczyk
authors.forename: J
authors.initials: J
authors.lastname: Giełdanowski
authors.forename: M
authors.initials: M
authors.lastname: Woźniak
authors.forename: W
authors.initials: W
authors.lastname: Dobryszycka
authors.forename: E M
authors.initials: EM
authors.lastname: Lemmel
authors.forename: M
authors.initials: M
authors.lastname: Katkiewicz
authors.forename: M
authors.initials: M
authors.lastname: Viljanen
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001388:Aziridines / Q000627:therapeutic use*; D001389:Azirines / Q000627:therapeutic use*; D002645:Chickens; D003545:Cysteine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology; D009186:Myelin Sheath / Q000276:immunology*; D000515:alpha 1-Antitrypsin / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D001388:Aziridines; D001389:Azirines; D000515:alpha 1-Antitrypsin; C016866:azimexon; C025196:cysteine hydrazide; D003545:Cysteine