Comparative study on effects of 14- and 16-membered macrolides on gastrointestinal motility in unanaesthetized dogs.
Comparative studies on the effects of 14-membered and 16-membered macrolides on gastrointestinal motility were conducted in unanaesthetized dogs. Midecamycin acetate, a new 16-membered macrolide, and leucomycin, another 16-membered macrolide, did not disturb the gastrointestinal motility and no dogs showed any adverse effects. In contrast, erythromycin stearate, erythromycin ethylsuccinate and triacetyloleandomycin, 14-membered macrolides, caused adverse effects such as strong contractile motility, nausea, vomiting and diarrhoea. The adverse effects of macrolides on the gastrointestinal tract are related to their chemical structure.
Nakayoshi
T
T
Pharmaceutical Development Laboratories, Meiji Seika Kaisha, Ltd., Kawasaki, Japan.
Izumi
M
M
Shinkai
S
S
Fujita
M
M
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004285:Dogs; D004917:Erythromycin / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007275:Injections, Intravenous; D007933:Leucomycins / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014217:Troleandomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007933:Leucomycins; D004917:Erythromycin; D014217:Troleandomycin; C011462:erythromycin stearate; C026483:midecamycin