Effects of sesame and cod liver oils on prostacyclin synthesis by the rat thoracic aorta.
The influence of sesame and cod liver oils (0.5 and 1 g/kg/day s.c. for 2 weeks) on arterial PGI2 synthesis in the rat was investigated using a rat platelet antiaggregatory bioassay and HPLC methods. Smaller doses did not affect PGI2 synthesis. However, sesame oil at a dose of 1 g/kg/day significantly stimulated PGI2 synthesis, whereas cod liver oil at the same dose significantly decreased the synthesis. Incubation of control tissues in presence of exogenous arachidonic acid (33 microM) significantly stimulated PGI2 synthesis, however, incubation of cod liver oil-treated tissues in presence of arachidonic acid resulted in PGI2 synthesis, similar to that observed in the nontreated controls. The changes observed in PGI2 synthesis in the tissues from oil-treated rats may have resulted from modulation in arachidonic acid release and/or direct effects on the enzymes involved in PGI2 synthesis. The oil-induced changes in PGI2 synthesis may partly contribute towards better understanding of the biochemical mechanisms that underly some of the in vivo actions of these oils.
el Tahir
K E
KE
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Hamad
E A
EA
Ageel
A M
AM
Abu Nasif
M A
MA
Gadkarim
E A
EA
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism*; D003060:Cod Liver Oil / Q000494:pharmacology*; D011464:Epoprostenol / Q000096:biosynthesis*; D005395:Fish Oils / Q000494:pharmacology*; D008297:Male; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012715:Sesame Oil / Q000494:pharmacology*
D005395:Fish Oils; D010938:Plant Oils; D003060:Cod Liver Oil; D012715:Sesame Oil; D011464:Epoprostenol