Insulin-dependent changes in lysosomal cathepsin D activity in rat liver, kidney, brain and heart.
Streptozotocin-induced diabetes resulted in a decrease in the cathepsin D activity (free and total) in rat liver, kidney, brain and heart with a concomitant increase in tissue protein content and amino acids pool size. Treatment with insulin brought about the restoration of the cathepsin D activity to normal or greater than normal levels; tissue protein content and amino acids pool size also returned to normal values.
Nerurkar
M A
MA
Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
Satav
J G
JG
Katyare
S S
SS
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology; D002402:Cathepsin D / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000201:enzymology*; D007328:Insulin / Q000494:pharmacology* / Q000627:therapeutic use; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D007328:Insulin; D002402:Cathepsin D