Kinetics of interleukin-1 production by macrophages during infection with Listeria monocytogenes.
Production of interleukin-1 (IL-1) by peritoneal macrophages from mice inoculated intravenously with Listeria monocytogenes was measured at increasing intervals of infection. IL-1 activity in the 24 h macrophage supernatants was determined by using the thymocyte PHA co-mitogenesis assay. IL-1 production increased as the infection progressed, reached a peak on the 9th or 10th day and then declined progressively to approach normal values by the 20th day. Our data on the kinetics of IL-1 levels during an acute infection with L.monocytogenes are discussed in relationship to the development of cell-mediated immunity and its regulation by macrophages.
Petit
J C
JC
Department of Microbiology, Faculty of Medicine Saint-Antoine, Paris, France.
Burghoffer
B
B
Richard
G
G
Daguet
G L
GL
D000818:Animals; D007111:Immunity, Cellular; D007375:Interleukin-1 / Q000096:biosynthesis*; D007700:Kinetics; D008088:Listeriosis / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D010529:Peritoneal Cavity / Q000166:cytology / Q000276:immunology
D007375:Interleukin-1