title: DNA synthesis in gametocytes of Plasmodium falciparum.
abstract: The DNA content of Plasmodium falciparum gametocytes during intra-erythrocytic development and during gametogenesis was established by cytophotometric methods. Intraerythrocytic micro- and macrogametocytes (Stage I-Stage VB) contain about twice the amount of DNA of haploid sporozoites and ringstages, indicating that DNA is synthesized during transformation of ringforms into Stage I gametocytes. Microgametocytes, after activation at pH 8, rapidly duplicate their genome several times, while the DNA content of macrogametocytes remains constant during gametogenesis.
authors.affiliation: Department of Tropical Veterinary Medicine and Protozoology, University of Utrecht, The Netherlands.
authors.forename: C J
authors.initials: CJ
authors.lastname: Janse
authors.forename: T
authors.initials: T
authors.lastname: Ponnudurai
authors.forename: A H
authors.initials: AH
authors.lastname: Lensen
authors.forename: J H
authors.initials: JH
authors.lastname: Meuwissen
authors.forename: J
authors.initials: J
authors.lastname: Ramesar
authors.forename: M
authors.initials: M
authors.lastname: Van der Ploeg
authors.forename: J P
authors.initials: JP
authors.lastname: Overdulve
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D005718:Gametogenesis; D005796:Genes; D006238:Haploidy; D010963:Plasmodium falciparum / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*
chemical_list: D004247:DNA