title: Distribution of cyclosporin A between blood cells and plasma of cardiac and renal transplant recipients.
abstract: The relationship between blood cells and plasma concentrations of cyclosporin A (Cy A) determined by radioimmunoassay, was investigated in 12 heart and 12 kidney transplant recipients. The decision between a linear and nonlinear model was made according to a standardized residuals plot. We observed high blood cells-plasma concentration ratios in the two groups, indicating a high affinity of Cy A for blood cells. The distribution of Cy A between blood cells and plasma was ascribed to a nonlinear saturable model in the two groups. According to our results we have simulated the blood-plasma concentration ratio of Cy A as a function of plasma Cy A concentration and hematocrit.
authors.affiliation: Service Hospitalo-Universitaire de Pharmacologie, Centre Hospitalier Intercommunal, Creteil, France.
authors.forename: C
authors.initials: C
authors.lastname: Hamberger
authors.forename: S
authors.initials: S
authors.lastname: Urien
authors.forename: J
authors.initials: J
authors.lastname: Barre
authors.forename: M
authors.initials: M
authors.lastname: Brandebourger
authors.forename: M
authors.initials: M
authors.lastname: Lemaire
authors.forename: P
authors.initials: P
authors.lastname: Lang
authors.forename: C
authors.initials: C
authors.lastname: Buisson
authors.forename: D
authors.initials: D
authors.lastname: Loisance
authors.forename: J P
authors.initials: JP
authors.lastname: Cachera
authors.forename: G
authors.initials: G
authors.lastname: Lagrue
mesh_terms: D000293:Adolescent; D000328:Adult; D001773:Blood Cells / Q000032:analysis*; D003524:Cyclosporins / Q000097:blood*; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D010949:Plasma / Q000032:analysis*
chemical_list: D003524:Cyclosporins