title: [The antigen-antibody reaction and its inhibition].
abstract: The sera of intact and immune animals contain factors capable of inhibiting the interaction of antibodies with the homologous antigen. These agglutination inhibiting (AI) factors not only block the antigen, thus competing with antibodies, but may induce the dissociation of the antigen-antibody complex. Heating of antisera at 60-63 degrees C leads to an increase in the activity of AI factors. The phenomenon of "prozone" in the agglutination test appears to be explained by the presence of AI factors in sera.
authors.forename: S A
authors.initials: SA
authors.lastname: Bobrovnik
mesh_terms: D000372:Agglutination Tests; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis / Q000276:immunology / Q000302:isolation & purification; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D001667:Binding, Competitive; D004306:Dose-Response Relationship, Immunologic; D005455:Fluorescent Antibody Technique; D006358:Hot Temperature; D007106:Immune Sera / Q000276:immunology; D007108:Immune Tolerance; D007124:Immunoenzyme Techniques; D051379:Mice; D013210:Staphylococcus / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D007106:Immune Sera
vernacular_title: Reaktsiia antigen-antitelo i ee ingibirovanie.