title: Cutaneous angiomas in POEMS syndrome. An ultrastructural and immunohistochemical study.
abstract: Cutaneous manifestations of POEMS (polyneuropathy, organomegaly, endocrinopathies, M-protein, and skin changes) syndrome in a 51-year-old white man included two types of hemangiomas, ie, cherry-type and subcutaneous hemangiomas. By light microscopy and immunohistochemistry, both types of tumors showed features of capillary hemangiomas. By electron microscopy, a peculiar finding of subcutaneous hemangiomas was the presence of slender abluminal processes of endothelial cells that were frequently anastomosing to form electron-lucent blebs. Although the precise etiopathogenesis of the vascular proliferations remains speculative, these lesions merit study since they constitute an easily recognizable marker of POEMS syndrome.
authors.affiliation: Department of Dermatology, Hôpital Edouard Herriot, Lyon, France.
authors.forename: J
authors.initials: J
authors.lastname: Kanitakis
authors.forename: H
authors.initials: H
authors.lastname: Roger
authors.forename: M
authors.initials: M
authors.lastname: Soubrier
authors.forename: J J
authors.initials: JJ
authors.lastname: Dubost
authors.forename: B
authors.initials: B
authors.lastname: Chouvet
authors.forename: P
authors.initials: P
authors.lastname: Souteyrand
mesh_terms: D004967:Estrogens / Q000097:blood; D005455:Fluorescent Antibody Technique; D006391:Hemangioma / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010265:Paraproteinemias / Q000473:pathology*; D012878:Skin Neoplasms / Q000648:ultrastructure*; D013577:Syndrome
chemical_list: D004967:Estrogens