title: Immunohistochemical study of carcinoembryonic antigen (CEA) in gastric tumors: correlation with preoperative serum levels, histologic type, and grade of anaplasia of the tumor.
abstract: The occurrence of carcinoembryonic antigen (CEA) was studied in 45 cases of gastric tumors by the immunoperoxidase technique. CEA-positive staining was found in 48.8% of tumors. A correlation was found between preoperative CEA values and tumor CEA staining. All patients with serum CEA values below 2.5 ng/ml showed CEA-negative staining of tumor. In patients with serum CEA values between 2.6 and 10 ng/ml, the tumors showed a minority of CEA-positive cells; but in patients with serum CEA values above 10 ng/ml, the tumors contained a majority of CEA-positive cells. CEA-positive staining was found in 34.4% of tumors of the diffuse type, and in 75% of tumors of the intestinal type. A high percentage of CEA positivity was seen in well-differentiated tumors (87.7%) compared to the moderately differentiated (69.2%), and to the undifferentiated (28.7%). A faint CEA-positivity was observed in intestinal metaplasia, while normal gastric mucosa was CEA-negative.
authors.affiliation: Dipartimento di Biopatologia Umana, Universitá degli Studi di Roma, La Sapienza, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Santeusanio
authors.forename: L
authors.initials: L
authors.lastname: Peronace
authors.forename: G
authors.initials: G
authors.lastname: Castagna
authors.forename: G
authors.initials: G
authors.lastname: De Muro
authors.forename: D
authors.initials: D
authors.lastname: Santi
authors.forename: A
authors.initials: A
authors.lastname: D'Orazio
authors.forename: C
authors.initials: C
authors.lastname: Amanti
authors.forename: G
authors.initials: G
authors.lastname: Midiri
authors.forename: C
authors.initials: C
authors.lastname: Campisi
authors.forename: G
authors.initials: G
authors.lastname: D'Ambra
mesh_terms: D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D002272:Carcinoembryonic Antigen