5-Fluorouracil-associated cardiotoxicity.
Cardiotoxicity manifested as myocardial ischemia is not generally recognized as a side effect of 5-fluorouracil. However, there have been at least 35 cases reported since 1975. In only one of these cases was a somewhat detailed evaluation done to rule out underlying coronary disease. The case reported here of 5-FU cardiotoxicity included an extensive cardiac evaluation to rule out underlying coronary disease and to assess spasm. The literature on 5-FU cardiotoxicity is also reviewed, and its possible mechanisms are analyzed.
Freeman
N J
NJ
Division of Medical Oncology, University of Massachusetts Medical School, Worcester 01605.
Costanza
M E
ME
D004562:Electrocardiography; D005472:Fluorouracil / Q000009:adverse effects* / Q000493:pharmacokinetics; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
D005472:Fluorouracil