title: Combined chemotherapy and surgery for pulmonary metastases from osteogenic sarcoma. Results of 10 years experience.
abstract: Twenty-three patients presented with isolated pulmonary metastases from osteogenic sarcoma following primary treatment by amputation or limb salvage, combined with chemotherapy. The metastases were treated by conservative surgical excision combined with chemotherapy; surgical excision was repeated for recurrent pulmonary metastases, provided there were none elsewhere. Six patients are alive and disease-free following their initial surgery. Of the remaining 17, 10 had recurrence confined to the lungs, and 7 developed extra-pulmonary metastases. The 10 with isolated pulmonary metastases all had further thoracotomies but eventually 7 died, as did all those with extra-pulmonary metastases. There were in all 45 operations, with 1 hospital death and 1 serious complication. Actuarial survival at 1, 3, 5 and 7 years was 87%, 45%, 39% and 31%, respectively. In the 10 patients who had recurrence of isolated pulmonary metastases, survival at 1 and 3 years was 70% and 34%.
authors.affiliation: United Bristol Hospital, UK.
authors.forename: A N
authors.initials: AN
authors.lastname: al-Jilaihawi
authors.forename: J
authors.initials: J
authors.lastname: Bullimore
authors.forename: M
authors.initials: M
authors.lastname: Mott
authors.forename: J D
authors.initials: JD
authors.lastname: Wisheart
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects; D012516:Osteosarcoma / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D011183:Postoperative Complications / Q000401:mortality; D011446:Prospective Studies; D012008:Recurrence; D015996:Survival Rate
chemical_list: D008727:Methotrexate