Macrophages and C3-deposition in early biopsies as a sign of poor prognosis in human kidney graft rejection.
Clinical characteristics such as retransplantation, cytotoxic antibodies, no or delayed graft onset, or early anuria seem to be important factors to define this group of patients. If early biopsies show intravascular presence of macrophages in venulae or capillaries usually combined with a C3-deposition in glomular capillary walls, the prognosis of graft outcome seems to be poor even with rather heavy antirejection therapy.
Hedman
L
L
Department of Surgery I, Sahlgren's Hospital, Gothenburg, Sweden.
Svalander
C
C
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis; D001706:Biopsy; D003176:Complement C3 / Q000032:analysis*; D006084:Graft Rejection; D006801:Humans; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation; D008264:Macrophages / Q000473:pathology*; D008875:Middle Aged; D011379:Prognosis
D000906:Antibodies; D003176:Complement C3