title: Amino acid sequence of the BSC-1 cell growth inhibitor (polyergin) deduced from the nucleotide sequence of the cDNA.
abstract: The complete amino acid sequence of the BSC-1 cell growth inhibitor, including its precursor polypeptide, is reported. The sequence was deduced from the nucleotide sequence of the cDNA. The N-terminal amino acid sequence of the mature bioactive BSC-1 cell growth inhibitor is identical with the N-terminal sequences of the factors that have been called type beta 2 transforming growth factor and cartilage-inducing factor B, suggesting that these are identical. The complete amino acid sequence of the mature BSC-1 cell growth inhibitor differs from that of human type beta transforming growth factor in 32 of the 112 amino acids. Polyergin is proposed as the name for the BSC-1 cell growth inhibitor.
authors.affiliation: Molecular Biology Laboratory, Salk Institute, San Diego, CA 92138.
authors.forename: S K
authors.initials: SK
authors.lastname: Hanks
authors.forename: R
authors.initials: R
authors.lastname: Armour
authors.forename: J H
authors.initials: JH
authors.lastname: Baldwin
authors.forename: F
authors.initials: F
authors.lastname: Maldonado
authors.forename: J
authors.initials: J
authors.lastname: Spiess
authors.forename: R W
authors.initials: RW
authors.lastname: Holley
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D002522:Chlorocebus aethiops; D004247:DNA / Q000235:genetics*; D006131:Growth Inhibitors / Q000235:genetics*; D007668:Kidney; D008969:Molecular Sequence Data; D010455:Peptides / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D016212:Transforming Growth Factor beta
chemical_list: D006131:Growth Inhibitors; D010455:Peptides; D016212:Transforming Growth Factor beta; D004247:DNA