Role of the endothelial antigen Eag-1 in the rejection of rat kidney allografts.
The immunogenicity of the minor histocompatibility antigen Eag-1 of the rat kidney endothelium was studied in renal allografts mismatched for antigens of the major histocompatibility complex (MHC). The rejection rates of BN.1L (RT1(1), Eag-1+), (BN.1LXMAXX)F1 (RT1l/n, Eag-1+), and LEW (RT1l, Eag-1-) kidneys transplanted into unsensitized, bilaterally nephrectomized MAXX (RT1n, Eag-1-) recipients were comparable, indicating that incompatibility for Eag-1 has no effect on the survival of MHC-incompatible kidney grafts. Transplantation of BN (RT1n, Eag-1+) and WKY (RT1k, Eag-1+) kidneys into unilaterally nephrectomized MAXX recipients led to a weak and inconsistent antibody response against Eag-1, indicating that MHC incompatibility does not influence the formation of antibodies against Eag-1.
Blankert
J J
JJ
Department of Nephrology, University Hospital, Leiden, The Netherlands.
Muizert
Y
Y
Weening
J J
JJ
Van Es
L A
LA
Paul
L C
LC
D000818:Animals; D001666:Binding Sites, Antibody; D004727:Endothelium / Q000276:immunology*; D006084:Graft Rejection; D006086:Graft vs Host Disease / Q000276:immunology / Q000473:pathology; D006649:Histocompatibility Antigens / Q000032:analysis / Q000276:immunology; D006650:Histocompatibility Testing; D007518:Isoantibodies / Q000096:biosynthesis; D007519:Isoantigens / Q000276:immunology*; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D011921:Rats, Inbred WKY
D006649:Histocompatibility Antigens; D007518:Isoantibodies; D007519:Isoantigens; C038353:histocompatibility antigens RT, rat