Immuno-electron microscopic study of calcitonin gene-related peptide (CGRP) in axis cylinders of the vagus nerve. CGRP is present in both myelinated and unmyelinated fibers.
The localization of immunoreactive calcitonin gene-related peptide (IR-CGRP) in vagus nerve fibers of the rat was studied with pre-embedding electron immunocytochemistry. IR-CGRP was localized in a small number (approximately 5%) of myelinated fibers and approximately 50% of unmyelinated fibers of the vagus. The immumoreactivity was observed in the dense cored vesicles (75-150 nm) and in the axoplasm, but absent in the clear vesicles.
Kakudo
K
K
Department of Pathology, Tokai University School of Medicine, Bouseidai Ishehara, Kanagawa, Japan.
Hasegawa
H
H
Komatsu
N
N
Nakamura
A
A
Itoh
Y
Y
Watanabe
K
K
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D015740:Calcitonin Gene-Related Peptide; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D009413:Nerve Fibers, Myelinated / Q000166:cytology / Q000648:ultrastructure*; D009479:Neuropeptides / Q000032:analysis* / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000166:cytology / Q000648:ultrastructure*
D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide