Birth prevalence and recurrence rates of neural tube defects in southern Alberta in 1970-81.
Given the observed variation in birth prevalence and recurrence rates of neural tube defects, it is important to obtain such data specific to a given locality for research and genetic counseling purposes. A review of hospital medical charts, the patient lists of the Medical Genetics and Myelomeningocele clinics at Alberta Children's Hospital and data from the Canadian Congenital Anomalies Surveillance System revealed the annual birth prevalence rate of neural tube defects in southern Alberta in 1970-81 to be 1.62/1000 total births. This figure suggests southern Alberta to be a low-frequency area. There was no significant variation in the annual rates of spina bifida, encephalocele or all neural tube defects combined over the study period. A significant linear decline in the frequency of births of anencephalic infants, however, was noted (p = 0.025). Information on the total reproductive history of the mothers revealed that the empiric risk of recurrence of a neural tube defect was 2.2%, and the risk to all siblings was estimated to be 2.3%. In future prevalence studies multiple sources of case ascertainment should be used, including data on pregnancies terminated because of a fetal neural tube defect.
Thunem
N Y
NY
Department of Pediatrics, University of Calgary.
Lowry
R B
RB
Tucker
B J
BJ
Medd
B W
BW
D000416:Alberta; D000757:Anencephaly / Q000453:epidemiology / Q000235:genetics; D004677:Encephalocele / Q000453:epidemiology / Q000235:genetics; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009436:Neural Tube Defects / Q000453:epidemiology* / Q000235:genetics; D011247:Pregnancy; D016136:Spina Bifida Occulta / Q000453:epidemiology / Q000235:genetics