Histologic characteristics of lichen planus transplanted onto nude mice and cultured in vitro.
Typical confluent lesions of lichen planus were transplanted onto nude mice and cultured in organ culture. The characteristic histologic appearance of lichen planus disappeared after grafting and became similar to normal skin within 6 weeks on nude mice; the dense lymphocyte infiltrate in dermis disappeared, the basal cell layer normalized, and the colloid bodies disappeared from epidermis, although some of them were found in dermis. The granular layer also normalized, but the stratum corneum remained hyperkeratotic 6 weeks after transplantation. In organ culture, characteristic histologic features of lichen planus disappeared in 3-5 days via a rapid necrosis of the upper part of the epidermis and formation of a new, normal-looking basal epidermis. These results suggest that lesions of lichen planus are primarily dependent on the influence of the host to maintain their typical histologic appearance.
Tammi
R
R
Department of Anatomy, University of Kuopio, Finland.
Hyyryläinen
A
A
Fräki
J E
JE
D000328:Adult; D000818:Animals; D006801:Humans; D008010:Lichen Planus / Q000473:pathology*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009924:Organ Culture Techniques; D016038:Skin Transplantation; D014183:Transplantation, Heterologous