Immunoglobulin allotypes and familial cutaneous malignant melanoma/dysplastic nevi. A family study.
Gm and Km allotypes were examined in 355 members of 14 large pedigrees segregating for autosomal dominant cutaneous malignant melanoma/dysplastic nevi. No evidence for linkage was found between the disease locus and the immunoglobulin loci. Furthermore, there was no association of G1m(2) or Gm(-1) with cutaneous malignant melanoma in the 14 independent family probands.
Buchmann
R B
RB
Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Md.
Bale
S J
SJ
Greene
M H
MH
Pandey
J P
JP
D002883:Chromosomes, Human, Pair 14; D002889:Chromosomes, Human, Pair 2; D004416:Dysplastic Nevus Syndrome / Q000235:genetics / Q000276:immunology*; D008040:Genetic Linkage; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology*
D007126:Immunoglobulin Allotypes; D007129:Immunoglobulin Gm Allotypes