title: [Ammonia release and binding processes and the activity of acid proteinase and glycolysis enzymes in the dynamics of experimental toxic adrenal encephalopathy].
abstract: The content of ammonium, glutamine, glutamate, aspartate and GABA, glutamine synthetase activity, acid proteinase, hexonase, phosphohexoisomerase and dehydrogenase glucose-6-phosphate were studied in dog brain homogenates after individual injections of Bacillus coli endotoxin (10 micrograms/kg) and adrenaline (75 micrograms/kg) into veins and their combined injections into the carotid artery. Isolated injections of endotoxin and adrenaline were shown to cause transient metabolic compensatory changes. Combined injections caused stable progressing brain metabolic disorders. It is suggested that neurochemical changes influence endogenous development of toxic adrenal encephalopathy.
authors.forename: V M
authors.initials: VM
authors.lastname: Kovalenko
authors.forename: R A
authors.initials: RA
authors.lastname: Trapezontseva
authors.forename: G A
authors.initials: GA
authors.lastname: Vilkov
mesh_terms: D000641:Ammonia / Q000378:metabolism*; D000818:Animals; D016282:Aspartic Acid Endopeptidases; D001927:Brain Diseases / Q000209:etiology / Q000378:metabolism*; D004285:Dogs; D010450:Endopeptidases / Q000378:metabolism*; D004731:Endotoxins / Q000008:administration & dosage; D004837:Epinephrine / Q000008:administration & dosage; D004926:Escherichia coli; D005260:Female; D005956:Glucose-6-Phosphate Isomerase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006593:Hexokinase / Q000378:metabolism; D008297:Male
chemical_list: D004731:Endotoxins; D000641:Ammonia; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; D005956:Glucose-6-Phosphate Isomerase; D004837:Epinephrine
vernacular_title: Protsessy osvobozhdeniia i sviazyvaniia ammiaka, aktivnost' kisloĭ proteinazy i fermentov glikoliza v dinamike éksperimental'noĭ toksiko-adrenalovoĭ éntsefalopatii.