title: New heterocyclic ring systems--V synthesis and pharmacological activity of 6H-1,3,4-thiadiazolo [3',2':1,2]-5-oxopyrimido [5,4-b] indole derivatives and of 1-phenyl-6H-1,2,4-triazolo [1',5':1,2]-5-oxopyrimido[5,4-b] indole.
abstract: As a part of a study on analgesic and antiinflammatory active condensed heterocyclic compounds containing the pyrimidinic ring, a number of 6H-1,3,4-thiadiazolo [3',2':1,2]-5-oxopyrimido [5,4-b]indole and 1-phenyl-6H-1,2,4-triazolo [1',5':1,2]-5-oxopyrimido [5,4-b] indole were synthesized and tested. The results of pharmacological assays are reported and discussed.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica dell'Università di Catania, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Russo
authors.forename: S
authors.initials: S
authors.lastname: Guccione
authors.forename: N A
authors.initials: NA
authors.lastname: Santagati
authors.forename: A
authors.initials: A
authors.lastname: Santagati
authors.forename: A
authors.initials: A
authors.lastname: Caruso
authors.forename: M G
authors.initials: MG
authors.lastname: Leone
authors.forename: A
authors.initials: A
authors.lastname: Felice
authors.forename: G
authors.initials: G
authors.lastname: Attaguile
authors.forename: M
authors.initials: M
authors.lastname: Amico Roxas
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007211:Indoles; D011743:Pyrimidines; D013830:Thiadiazoles; D014230:Triazoles