[Effect of topical glucocorticoids on endogenous cortisol production].
In a randomized double blind study, we investigated the systemic effects of 3 different ointments containing corticoids. Every 7 patients out of a total of 21 patients suffering from various skin diseases were daily treated with 40 g of one of the 3 corticoid preparations over 8 days (group A: 0.05% clobetasol-17-propionate; group B: 0.25% fluocortolone trimethyl acetate; group C: 0.25% fluocortolone trimethyl acetate + 0.25% fluocortolone capronate). The plasma cortisol levels were determined by radioimmune assay. In group B and C, we did not observe any effect on the pituitary-adrenal axis, whereas in group A the plasma cortisol levels were extremely low already after 1 day of corticoid application. This adrenal suppression did not return to normal within 4 days after discontinuation of the corticoid. Our results suggest that highly potent topical corticoids are capable of adrenal suppression even without occlusive dressing and even in healthy persons.
Neumann
R A
RA
II. Universitäts-Hautklinik Wien.
Schmidt
J B
JB
Spona
J
J
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D002990:Clobetasol / Q000009:adverse effects / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005448:Fluocortolone / Q000009:adverse effects / Q000031:analogs & derivatives; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012871:Skin Diseases / Q000188:drug therapy*; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D005448:Fluocortolone; D002990:Clobetasol; D006854:Hydrocortisone
Einfluss topischer Glukokortikoide auf die körpereigene Cortisolproduktion.