[Monoclonal antibodies against the alpha-chain of human lymphocyte function-associated antigen-1].
The goal of the investigation was to further characterize ICO-II monoclonal antibodies. ICO-II have been shown to block NK activity of mononuclear cells from the blood of healthy donors against K-562 and Molt-4 target cells, cytotoxic T lymphocytes induced in a 7-day mixed lymphocyte culture, the reaction of lymphocyte blast cell transformation to phytohemagglutinin and the formation of En-rosettes. The molecular weight of the antigen detected by ICO-II is 180 KD. ICO-II are shown to detect alpha-subunit of human lymphocyte function-associated antigen-I (LFA-I).
Baryshnikov
A Iu
AIu
Dubinkin
I V
IV
Savel'eva
E V
EV
Veskova
T K
TK
Tupitsyn
N N
NN
D000208:Acute Disease; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D006801:Humans; D007938:Leukemia / Q000276:immunology; D016169:Lymphocyte Function-Associated Antigen-1; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D016169:Lymphocyte Function-Associated Antigen-1
Monoklonal'nye antitela protiv al'fa-tsepi chelovecheskogo limfotsitarnogo funktsional'no-assotsiirovannogo antigena-(LFA-1).