title: Effectiveness of acarbose, an alpha-glucosidase inhibitor, in uncontrolled non-obese non-insulin dependent diabetes.
abstract: The effect of acarbose, an alpha-glucosidase inhibitor, on glycaemic control, was compared with placebo in a double-blind, randomised, group comparison study during 16 weeks in 20 non-obese non-insulin dependent diabetic patients in whom sulphonylurea treatment had been withdrawn. There was significant deterioration in glycaemic control as assessed by HbA1 following withdrawal of the sulphonylurea. There was no significant improvement in HbA1 between weeks 0 and 16 in either the acarbose (11.3% and 12.4% respectively) or the placebo group (10.6% and 12.2% respectively). In both the acarbose and placebo treated groups fasting glucose and insulin concentrations were unaltered. This study also suggests that acarbose was not an effective substitute for sulphonylureas in non-obese Type 2 diabetes uncontrolled by diet alone.
authors.affiliation: Diabetic and Dietetic Department, Royal Infirmary, Edinburgh, UK.
authors.forename: D R
authors.initials: DR
authors.lastname: Buchanan
authors.forename: A
authors.initials: A
authors.lastname: Collier
authors.forename: E
authors.initials: E
authors.lastname: Rodrigues
authors.forename: A M
authors.initials: AM
authors.lastname: Millar
authors.forename: R S
authors.initials: RS
authors.lastname: Gray
authors.forename: B F
authors.initials: BF
authors.lastname: Clarke
mesh_terms: D020909:Acarbose; D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight; D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013997:Time Factors; D014312:Trisaccharides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000520:alpha-Glucosidases / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D020909:Acarbose; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D065089:Glycoside Hydrolase Inhibitors; D007328:Insulin; D014312:Trisaccharides; D000520:alpha-Glucosidases