Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release.
MK-801 was found to be more potent than phencyclidine (PCP) as an inhibitor of N-methyl-D-aspartate-induced [3H]norepinephrine (NE) release and [3H]TCP binding in the hippocampus. On the other hand, MK-801 was slightly less potent than PCP to enhance kainate-stimulated [3H]NE release and to inhibit hippocampal [3H]NE uptake. Further, MK-801 was strikingly less potent than PCP as an inhibitor of striatal synaptosomal [3H]dopamine uptake. These data are discussed with reference to the therapeutic potential of MK-801.
Snell
L D
LD
Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston 77550.
Yi
S J
SJ
Johnson
K M
KM
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D002395:Catecholamines / Q000378:metabolism*; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D006624:Hippocampus / Q000187:drug effects; D066298:In Vitro Techniques; D016202:N-Methylaspartate; D009638:Norepinephrine / Q000378:metabolism*; D010622:Phencyclidine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats
D002395:Catecholamines; D003986:Dibenzocycloheptenes; D001224:Aspartic Acid; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; C012058:tenocyclidine; D010622:Phencyclidine; D009638:Norepinephrine