Distribution of cyclosporin A between blood cells and plasma of cardiac and renal transplant recipients.
The relationship between blood cells and plasma concentrations of cyclosporin A (Cy A) determined by radioimmunoassay, was investigated in 12 heart and 12 kidney transplant recipients. The decision between a linear and nonlinear model was made according to a standardized residuals plot. We observed high blood cells-plasma concentration ratios in the two groups, indicating a high affinity of Cy A for blood cells. The distribution of Cy A between blood cells and plasma was ascribed to a nonlinear saturable model in the two groups. According to our results we have simulated the blood-plasma concentration ratio of Cy A as a function of plasma Cy A concentration and hematocrit.
Hamberger
C
C
Service Hospitalo-Universitaire de Pharmacologie, Centre Hospitalier Intercommunal, Creteil, France.
Urien
S
S
Barre
J
J
Brandebourger
M
M
Lemaire
M
M
Lang
P
P
Buisson
C
C
Loisance
D
D
Cachera
J P
JP
Lagrue
G
G
D000293:Adolescent; D000328:Adult; D001773:Blood Cells / Q000032:analysis*; D003524:Cyclosporins / Q000097:blood*; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D010949:Plasma / Q000032:analysis*
D003524:Cyclosporins