title: Resistance to infection with Eimeria vermiformis in mouse radiation chimeras is determined by donor bone-marrow cells.
abstract: The course of infection with Eimeria vermiformis was determined in BALB/b, BALB/c, and C57BL/10ScSn (B10) mice and in radiation chimeras prepared from the H-2-compatible BALB/b and B10 mice. The BALB strains, irrespective of H-2 haplotype, were resistant, the B10 mice were susceptible, and in the chimeras infection was characterized by the genotype of the donated bone-marrow cells and not by the phenotype of the recipient. Thus, the genetic control of relative resistance or susceptibility to infection with this parasite is expressed through bone-marrow-derived cells.
authors.affiliation: Houghton Laboratory, Institute for Animal Health, Huntingdon, United Kingdom.
authors.forename: H S
authors.initials: HS
authors.lastname: Joysey
authors.forename: D
authors.initials: D
authors.lastname: Wakelin
authors.forename: M E
authors.initials: ME
authors.lastname: Rose
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000276:immunology*; D016026:Bone Marrow Transplantation; D003048:Coccidiosis / Q000235:genetics / Q000276:immunology*; D007111:Immunity, Cellular; D051379:Mice; D008815:Mice, Inbred Strains; D011828:Radiation Chimera; D013601:T-Lymphocytes / Q000276:immunology