Staphylococcus aureus and Staphylococcus epidermidis strains differ in interleukin 2 inducing activity.
Heat-killed preparations of different Staphylococcus aureus and Staphylococcus epidermidis strains were compared for interleukin 2 (IL-2) inducing activity in cultures of human mononuclear cells (MNC). S. aureus strains exhibited a strong individual variation, but they induced considerably more IL-2 than did S. epidermidis strains. Enterotoxin production, coagulase production, pigment formation and the phage type of the staphylococci showed no strict correlation of any of these properties with the IL-2 inducer activity. The results indicate that the IL-2 inducing activity may be a differential feature of S. aureus and S. epidermidis.
Nagy
Z N
ZN
Institute of Microbiology, University Medical School, Szeged.
Rosztóczy
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I
D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000276:immunology*; D013212:Staphylococcus epidermidis / Q000276:immunology*
D007376:Interleukin-2; D003208:Concanavalin A