Interleukin 1 as a tumor cytostatic mediator released from tumor ascites-treated macrophages.
Peritoneal macrophages from DBA/2 mice, elicited by injection of Corynebacterium parvum (C.p.), were in vitro activated to Eb tumor cytostasis by incubation with tumor-induced ascites that was harvested 7 days after intraperitoneal Eb injection. The active cytostasis-mediating compound was found to be interleukin 1 (IL 1). When tumor ascites was fractionated according to molecular weight size, the most active IL 1-inducing fraction was found to comprise molecules of greater than 100,000 daltons. The data show that tumor-bearing hosts are capable of producing compounds that induce a high IL 1 secretion which may enable macrophages to mount an antiproliferative effect against tumor cells.
Gong
J H
JH
Institute of Immunology, Philipps University, Marburg, Federal Republic of Germany.
Renz
H
H
Nain
M
M
Gemsa
D
D
D000818:Animals; D001201:Ascites / Q000276:immunology; D003603:Cytotoxins / Q000096:biosynthesis*; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis*; D007940:Leukemia L5178 / Q000276:immunology; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains
D003603:Cytotoxins; D007375:Interleukin-1