Immunohistochemical examination of Peyer's patches in autoimmune mice.
The distribution of T-cells and B-cells in Peyer's patches was examined in three autoimmune model mice, MRL/Mp-lpr/lpr, BXSB, NZBWF1/J mice and normal BALB/c mice, between one and ten months old. A multiple layering technique was used for immunohistochemical detection of lymphocyte surface antigens of T-cells (Thy1.2, Lyt1, Lyt2) and B-cells (surface IgM) and peanut agglutinin receptor for germinal center cells. The T-cell population of female MRL/Mp-lpr/lpr mice increased markedly with age, and the B-cell population of the male BXSB mouse tended to increase. However, little change was observed with age in the NZBWF1/J mice. The immunohistochemical properties of the Peyer's patches in the three autoimmune model mice were different.
Yoshioka
H
H
Department of Pathology, Kyoto University, Japan.
Ohshio
G
G
Furukawa
F
F
Inada
M
M
Miyata
S
S
Hamashima
Y
Y
Miyake
T
T
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010581:Peyer's Patches / Q000032:analysis* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D001323:Autoantibodies