title: [Open multicenter study of the differential diagnosis of erectile dysfunction with a papaverine-phentolamine combination (BY023)].
abstract: We report the results of an open multicenter clinical trial with 115 patients. The results of a pharmacological test using intracavernously applied mixture of papaverine and phentolamine were compared with the results of a multidisciplinary evaluation of erectile dysfunction. Sensitivity and specificity of our test were determined. The injection of our drug solution caused an increase in tumescence and/or rigidity in all patients. The evaluation of the dose dependent erectile response makes it possible to distinguish between the three main pathogenetic principles: non-vascular, arterial and venous etiology of erectile dysfunction. The pharmacological test requires one to four intracavernous injections of 0.5-3.0 ml of the drug solution (7.5-45 mg papaverine hydrochloride, 0.25-1.5 mg phentolamine mesylate).
authors.affiliation: Abteilung Urologie, Städtische Kliniken Kassel.
authors.forename: K P
authors.initials: KP
authors.lastname: Jünemann
authors.forename: E
authors.initials: E
authors.lastname: Jecht
authors.forename: V
authors.initials: V
authors.lastname: Müller-Mattheis
authors.forename: W H
authors.initials: WH
authors.lastname: Weiske
authors.forename: U
authors.initials: U
authors.lastname: Wetterauer
authors.forename: M
authors.initials: M
authors.lastname: Baccouche
authors.forename: R
authors.initials: R
authors.lastname: Lühmann
authors.forename: M
authors.initials: M
authors.lastname: Zentgraf
authors.forename: W
authors.initials: W
authors.lastname: Bähren
authors.forename: J E
authors.initials: JE
authors.lastname: Altwein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003937:Diagnosis, Differential; D004338:Drug Combinations; D007172:Erectile Dysfunction / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010208:Papaverine; D010410:Penile Erection / Q000187:drug effects; D010413:Penis / Q000098:blood supply; D010646:Phentolamine; D012039:Regional Blood Flow / Q000187:drug effects; D014463:Ultrasonography
chemical_list: D004338:Drug Combinations; C055514:papaverine, phentolamine drug combination; D010208:Papaverine; D010646:Phentolamine
vernacular_title: Offene Multizenterstudie zur Differentialdiagnostik der erektilen Dysfunktion mit einer Papaverin-Phentolamin-Kombination (BY023).