Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas.
The acute effects of recombinant human interleukin-1 beta (rIL-1) on basal and glucose-stimulated insulin release were investigated in the isolated perfused pancreas. At a concentration of 20 micrograms/l rIL-1 had no effect on basal insulin release, but increased the total amount of insulin released during first and second phase insulin release in response to 20 mmol/l D-glucose in the rat pancreas (P less than 0.05). In addition, 26 micrograms/l of rIL-1 potentiated insulin release in response to square wave infusions of stimulatory concentrations of glucose (11 mmol/l) in the porcine pancreas. We hypothesize that IL-1 in the systemic circulation may affect B cell function in vivo.
Wogensen
L D
LD
Steno Memorial Hospital, Gentofte, Denmark.
Mandrup-Poulsen
T
T
Markholst
H
H
Mølvig
J
J
Lernmark
A
A
Holst
J J
JJ
Dinarello
C A
CA
Nerup
J
J
D000818:Animals; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D010477:Perfusion; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine
D007328:Insulin; D007375:Interleukin-1