title: Long-term alcohol consumption reduces the number of neuronal nuclear pores. A morphometric study undertaken in CA3 hippocampal pyramids of rats.
abstract: A close relationship between the number of nuclear pores and the cellular protein synthesis activity is known to exist. Previous biochemical investigations lead to admit that the widespread neuronal alcohol-induced degenerative changes could depend on a decrease in the neuronal protein synthesis. The morphometric analysis made on the nuclear pore complexes of CA3 hippocampal pyramids of long-term alcohol-fed rats fully supports this attractive hypothesis, since it has been found a marked reduction in the number of pores per unit surface area of nuclear membrane, together with a reduction in their total number per nucleus.
authors.affiliation: Department of Anatomy, Oporto School of Medicine, Portugal.
authors.forename: J P
authors.initials: JP
authors.lastname: Andrade
authors.forename: A
authors.initials: A
authors.lastname: Cadete-Leite
authors.forename: M M
authors.initials: MM
authors.lastname: Paula-Barbosa
authors.forename: B
authors.initials: B
authors.lastname: Volk
authors.forename: M A
authors.initials: MA
authors.lastname: Tavares
mesh_terms: D000437:Alcoholism / Q000473:pathology*; D000818:Animals; D006624:Hippocampus / Q000648:ultrastructure*; D008297:Male; D009685:Nuclear Envelope / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains