Direct-acting alkylating and acylating agents. DNA adduct formation, structure-activity, and carcinogenesis.
Van Duuren
B L
BL
Institute of Environmental Medicine, New York University Medical Center, New York 10016.
D000215:Acylation; D000447:Aldehydes / Q000633:toxicity; D000477:Alkylating Agents / Q000633:toxicity*; D000818:Animals; D001725:Bis(Chloromethyl) Ether / Q000633:toxicity; D002273:Carcinogens; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D004852:Epoxy Compounds / Q000633:toxicity; D015946:Ethylene Dibromide / Q000633:toxicity; D013329:Structure-Activity Relationship; D014752:Vinyl Chloride / Q000633:toxicity
D000447:Aldehydes; D000477:Alkylating Agents; D002273:Carcinogens; D004852:Epoxy Compounds; D015946:Ethylene Dibromide; D001725:Bis(Chloromethyl) Ether; D004247:DNA; C007871:glycinaldehyde; D014752:Vinyl Chloride