Linear order of the four BCR-related loci in 22q11.
It has recently been shown the a probe for the 3' end of the BCR gene recognizes a family of four BCR-like genes that map to 22q11. Using a panel of somatic cell hybrids with rearrangement of chromosome 22, we have determined their order within 22q11: BCR-2, BCR4, BCR1, BCR-3, with BCR-2 the most centromere proximal. All of the BCR-like genes map proximal to the 22q11-q12 breakpoint of a t(11;22) in a Ewing sarcoma.
Budarf
M
M
Department of Pediatrics and Human Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104.
Canaani
E
E
Emanuel
B S
BS
D015139:Blotting, Southern; D002460:Cell Line; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D006822:Hybrid Cells; D009693:Nucleic Acid Hybridization; D009857:Oncogenes