[24,25-Dihydroxyvitamin D3 modulates the effect of 1alpha-hydroxyvitamin D3 on B lymphocyte maturation in chickens].
Patterns of calcium metabolism and maturation of lymphocytes in chicken Fabricius bursa were studied in presence of various doses of I alpha-hydroxy vitamin D3 and 24,25-dihydroxy vitamin D3 administered separately and at various combinations. 24,25(OH2)D3 was distinctly less effective in the antirickets activity as compared with I alpha (OH)D3. A decrease in mass of Fabricius bursa and inhibition of lymphocytes maturation within early steps were observed in the birds with rickets. A toxic dose of I alpha (OH)D3 caused pseudohypertrophy of Fabricius bursa. Small doses of these drugs administered simultaneously exhibited higher effect both on rickets and on stimulation of B lymphocytes maturation. 24,25(OH)2D3 attenuated the negative effect of either subtoxic (0.65 nmol/day) or toxic (1.3 nmol/day) doses of I alpha (OH)D3 on an increase in body mass, calcemia, ash content of bones, content of small lymphocytes in Fabricius bursa.
Babarykin
D A
DA
Smiltnieks
E Kh
EKh
Valinietse
M Iu
MIu
Bauman
V K
VK
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism*; D002060:Bursa of Fabricius / Q000378:metabolism / Q000473:pathology; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002454:Cell Differentiation; D002645:Chickens; D004357:Drug Synergism; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D014808:Vitamin D Deficiency / Q000378:metabolism* / Q000473:pathology
D006887:Hydroxycholecalciferols; D002117:Calcitriol; D002118:Calcium; C008088:alfacalcidol
24,25-Digidroksivitamin D3 moduliruet deĭstvie 1alpha-gidroksivitamina D3 na sozrevanie B-limfotsitov u tsipliat.