Amelioration of normothermic canine liver ischemia with prostacyclin.
A model of hepatic ischemia was developed in dogs using a pump-driven splanchnic-to-jugular vein bypass during crossclamping of the portal triad. An LD50 was established with three hours of ischemia. PGI2 given for one hour before the ischemic insult ameliorated the ischemic injury and increased survival.
Todo
S
S
Department of Surgery, University of Pittsburgh, PA.
Yokoi
H
H
Podesta
L
L
ChapChap
P
P
Pan
C
C
Okuda
K
K
Kamiyama
Y
Y
Demetris
J
J
Makowka
L
L
Iwatsuki
S
S
D000818:Animals; D004285:Dogs; D011464:Epoprostenol / Q000494:pharmacology*; D007511:Ischemia / Q000503:physiopathology; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology
D011464:Epoprostenol