Responses of human B-cells to recombinant lymphokines.
The effects of recombinant or purified cytokines on the growth and differentiation of human B-cells from a variety of sources were evaluated. The results suggest that IL-1, BCGF and BSF-2 have either "growth-factor" or "differentiation-factor" activity and that only IL-2 has both these functions. In addition, evidence is presented that the two forms of human IL-1 affect B-cell growth differently. Finally, the separation of human normal and leukaemic B-cells into subsets defined by their buoyant cell density, is described.
Gallagher
G
G
Immunology Division, University of Strathclyde, Todd Centre, Glasgow.
Taylor
N
N
Willdridge
J
J
Christie
J F
JF
Stimson
W H
WH
D001402:B-Lymphocytes / Q000145:classification / Q000276:immunology*; D002455:Cell Division; D002478:Cells, Cultured; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology; D015847:Interleukin-4; D015850:Interleukin-6; D007378:Interleukins / Q000276:immunology; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology*
D007375:Interleukin-1; D015850:Interleukin-6; D007378:Interleukins; D008222:Lymphokines; D011994:Recombinant Proteins; D015847:Interleukin-4