Bupivacaine acute toxicity protection by diazepam in mice.
1. The effects of acute and 8-day administration of diazepam (DZP) on the acute toxicity of bupivacaine in the mouse were studied. 2. Protection of bupivacaine-induced acute toxicity by DZP appears to be dose-dependent after treatment for 8 days but not after acute treatment.
Bruguerolle
B
B
Laboratoire de Pharmacologie Médicale, Faculté de Médecine, Marseille, France.
Emperaire
N
N
Ottomani
A
A
Manelli
J C
JC
D000818:Animals; D002045:Bupivacaine / Q000037:antagonists & inhibitors / Q000633:toxicity*; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007273:Injections, Intramuscular; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D003975:Diazepam; D002045:Bupivacaine