Acetic acids bearing the 1-phenyl-1H-indazole nucleus with analgesic and antiinflammatory activity.
The synthesis of [(1-phenyl-1H-indazol-4-yl)oxy]acetic acid (IV), (1-phenyl-1H-indazol-4-yl)acetic acid (IX) and (1,5,6,7)tetrahydro-1-phenyl-4H-indazol-4-iminooxy)acetic acid (XIII) starting from 1,5,6,7-tetrahydro-1-phenyl-4H-indazol-4-one (I) is described. These compounds showed a good antiinflammatory activity in rats, and an analgesic activity in mice similar or comparable to that of indomethacin.
Mosti
L
L
Istituto di Scienze Farmaceutiche, Università di Genova, Italy.
Menozzi
G
G
Schenone
P
P
Molinario
L
L
Conte
F
F
Montanario
C
C
Marmoe
E
E
D000085:Acetates / Q000032:analysis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007191:Indazoles / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis*; D051381:Rats
D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007191:Indazoles; D011720:Pyrazoles