title: [Synthesis and pharmacologic activity of 9-R-octahydroindolo[2,3-a]quinolazine].
abstract: By acid induced cyclization of quinolizidin-1-one 4-R-phenylhydrazones several derivatives of 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine (1), bearing a substituent on position 9, were prepared. When R = Cl this reaction gave rise also to a red-orange compound to which the structure (V) of 1-(p-chloro)phenylazo-3,4,6,7,8,9-hexahydroquinolizine was assigned. Substances (1 b)-(1-f) were tested for spontaneous locomotor, muscle relaxant, analgesic, antiinflammatory, diuretic and cardiovascular activities and for influence on pentylentetrazole and sodium pentobarbital actions. Interesting levels of activity were exhibited in several cases.
authors.affiliation: Istituto di Scienze Farmaceutiche, Università di Genova.
authors.forename: C
authors.initials: C
authors.lastname: Boido-Canu
authors.forename: V
authors.initials: V
authors.lastname: Boido
authors.forename: F
authors.initials: F
authors.lastname: Sparatore
authors.forename: A
authors.initials: A
authors.lastname: Sparatore
authors.forename: V
authors.initials: V
authors.lastname: Susanna
authors.forename: S
authors.initials: S
authors.lastname: Russo
authors.forename: M L
authors.initials: ML
authors.lastname: Cenicola
authors.forename: E
authors.initials: E
authors.lastname: Marmo
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D004232:Diuretics / Q000138:chemical synthesis; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis; D010424:Pentobarbital / Q000037:antagonists & inhibitors; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011807:Quinolizines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004232:Diuretics; D007211:Indoles; D009125:Muscle Relaxants, Central; D011807:Quinolizines; D010424:Pentobarbital; D010433:Pentylenetetrazole
vernacular_title: Sintesi ed attività farmacologica di 9-R-ottaidroindolo [2,3-a]chinolizine.