[In vitro sensitivity of Aspergillus to terbinafine: comparative study on amphotericin B, 5-fluorocytosine and ketoconazole].
Terbinafine, a new antifungal agent derived from allylamine, effective by oral route, was tested against 32 different strains of Aspergilli to determine its in vitro efficiency compared with amphotericin B, 5-fluorocytosine and ketoconazole. Antifungal sensitivity was determine by the MIC method in liquid and solid mediums (Sabouraud, Casitone, YMA, YMB, YNB): with MIC between 0.005 and 5 micrograms/ml, whatever the species and the techniques, terbinafine is more efficient than amphotericin B, ketoconazole (0.5 to 100 micrograms/ml) and 5-FC (1-greater than 100 micrograms/ml).
Goudard
M
M
Laboratoire de Botanique et Cryptogamie, Faculté de Pharmacie, Marseille, France.
Regli
P
P
Buffard
Y
Y
Gabriel
B
B
D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects*; D005437:Flucytosine / Q000494:pharmacology*; D007654:Ketoconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000494:pharmacology*; D000077291:Terbinafine
D000935:Antifungal Agents; D009281:Naphthalenes; D000666:Amphotericin B; D005437:Flucytosine; D000077291:Terbinafine; D007654:Ketoconazole
Sensibilité in vitro des Aspergillus à la terbinafine: étude comparative avec l'amphotéricine B, la 5-fluorocytosine et le kétoconazole.