title: An update of two randomized trials in previously untreated multiple myeloma comparing melphalan and prednisone versus three- and five-drug combinations: an Argentine Group for the Treatment of Acute Leukemia Study.
abstract: An update of two consecutive randomized studies in previously untreated multiple myeloma was performed. The first study (10-M-73) began in 1973; 150 patients were treated with melphalan and prednisone (MP) or semustine, cyclophosphamide, and prednisone (MeCP). In a second randomized study (3-M-77), begun in 1977, 260 patients were treated with MP or melphalan, prednisone, cyclophosphamide, semustine, and vincristine (MPCCV). A total of 27 of the 67 patients (40%) treated with MP and 33 of the 83 patients (40%) treated with MeCP showed a good response in protocol 10-M-73; 48 of 145 patients (33%) treated with MP and 51 of the 115 patients (44%) treated with MPCCV in protocol 3-M-77 obtained a good response (P is not significant). Median survival in protocol 10-M-73 was 30 months for MeCP and 38 months for MP. At 84 months, 19% and 9% remain alive, respectively. Median survival for protocol 3-M-77 was 44 months for those treated with MPCCV and 42 months for MP. At 60 months, 9% and 11% remain alive; this difference was not significant. Also, there was no survival difference for favorable or unfavorable prognostic groups among the four treatment arms of both protocols. It can be concluded, with a long-term follow-up of both protocols, that the combination of MP is as effective as the three- and five-drugs combinations, and in view of its simplicity and cost-saving advantages, it should be favored for initial therapy of multiple myeloma patients.
authors.affiliation: Instituto de Investigaciones Hematológicas, Buenos Aires, Argentina.
authors.forename: S
authors.initials: S
authors.lastname: Pavlovsky
authors.forename: C
authors.initials: C
authors.lastname: Corrado
authors.forename: M T
authors.initials: MT
authors.lastname: Santarelli
authors.forename: J
authors.initials: J
authors.lastname: Saslavsky
authors.forename: F
authors.initials: F
authors.lastname: Cavagnaro
authors.forename: M
authors.initials: M
authors.lastname: Palau
authors.forename: M
authors.initials: M
authors.lastname: de Tezanos Pinto
authors.forename: A
authors.initials: A
authors.lastname: Huberman
authors.forename: J M
authors.initials: JM
authors.lastname: Lein
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D008558:Melphalan / Q000627:therapeutic use; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000401:mortality; D011241:Prednisone / Q000627:therapeutic use; D011379:Prognosis; D011897:Random Allocation
chemical_list: D008558:Melphalan; D011241:Prednisone