Meiotic segregation of human sperm chromosomes in translocation heterozygotes: report of a t(9;10)(q34;q11) and a review of the literature.
Meiotic segregation products were studied in sperm from a man who was heterozygous for a reciprocal translocation, t(9;10)(q34;q11). A total of 171 sperm chromosome complements were studied by in vitro fertilization of hamster eggs. All possible 2:2 and 3:1 meiotic segregations were observed with the following frequencies: alternate, 41%; adjacent-1, 48%; adjacent-2, 5%; 3:1, 6%. Within alternate segregations, the number of normal sperm (35) was not significantly different from the number of sperm carrying a balanced form of the translocation (33), as expected. The proportion of sperm with an unbalanced form of the translocation was 60%. There was no evidence for an interchromosomal effect, since the frequencies of numerical (8%) and structural (15%) chromosomal abnormalities (both unrelated to the translocation) were within the normal range of control donors. The literature on a total of 10 translocation heterozygotes studied by sperm chromosome analysis was reviewed.
Martin
R H
RH
Department of Pediatrics, University of Calgary, Alberta, Canada.
D000328:Adult; D000782:Aneuploidy; D000818:Animals; D002879:Chromosomes, Human, Pair 10 / Q000648:ultrastructure*; D002899:Chromosomes, Human, Pair 9 / Q000648:ultrastructure*; D006224:Cricetinae; D005260:Female; D006579:Heterozygote; D006801:Humans; D008297:Male; D008540:Meiosis; D009865:Oocytes; D010375:Pedigree; D013094:Spermatozoa / Q000648:ultrastructure*; D014178:Translocation, Genetic