title: The relationship between primary hyperparathyroidism and diabetes mellitus.
abstract: Previous reports have suggested that control of diabetes improves after successful parathyroidectomy for primary hyperparathyroidism. To investigate this proposition further, a review was made of all insulin-requiring diabetics undergoing curative parathyroidectomy at the Mayo Clinic between 1970 and 1984 (36 patients). All contemporary insulin-requiring diabetics undergoing thyroidectomy for benign euthyroid disease served as a control group (34 patients). One patient in each group had type I diabetes mellitus, and the remainder had type II diabetes mellitus. Preoperative insulin requirements, insulin requirements at follow-up, and change in insulin requirements did not differ significantly between the two groups. This study suggests that parathyroidectomy does not lead to a statistically significant reduction in the insulin requirements of diabetic patients with primary hyperparathyroidism and that coexistent type II diabetes mellitus should not be considered a further indication for parathyroidectomy in patients with primary hyperparathyroidism.
authors.affiliation: Department of Surgery, Mayo Clinic, Rochester, MN 55905.
authors.forename: M P
authors.initials: MP
authors.lastname: Bannon
authors.forename: J A
authors.initials: JA
authors.lastname: van Heerden
authors.forename: P J
authors.initials: PJ
authors.lastname: Palumbo
authors.forename: D M
authors.initials: DM
authors.lastname: Ilstrup
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000601:surgery; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000601:surgery*; D013959:Thyroid Diseases / Q000150:complications / Q000601:surgery; D013965:Thyroidectomy
chemical_list: D007328:Insulin