title: Laxative abuse.
abstract: Two types of laxative abuse are described, namely habitual abuse and surreptitious abuse. Phenolphthalein and the anthraquinone derivatives have been most abused in this respect. Long-term anthraquinone use may lead to melanosis coli and cathartic colon, with typical histological and radiological features. Surreptitious abuse presents as a factitious illness with diarrhoea, hypokalaemia, abdominal pain and thirst, as well as melanosis coli. Over 90% of cases occur in women, many of whom work in a paramedical situation. Wider recognition of the range of normal bowel habit and a cultural change with rejection of Victorian mores and concepts of 'intestinal auto-intoxication' have led to a decrease in inappropriate laxative consumption. However, they are still widely prescribed and bought. Although it was as long ago as 1937 that Witts [108] drew attention to the dangers associated with the use of laxatives, his lesion still needs to be preached today.
authors.affiliation: Department of Medicine, Hope Hospital, University of Manchester School of Medicine, Salford, UK.
authors.forename: K J
authors.initials: KJ
authors.lastname: Moriarty
authors.forename: D B
authors.initials: DB
authors.lastname: Silk
mesh_terms: D002400:Cathartics; D003108:Colonic Diseases / Q000209:etiology; D006801:Humans; D019966:Substance-Related Disorders / Q000150:complications / Q000175:diagnosis / Q000523:psychology
chemical_list: D002400:Cathartics