Effect of nucleotide restriction and supplementation on resistance to experimental murine candidiasis.
The influence of dietary nucleotides on susceptibility to candidiasis in mice was studied using two criteria: animal survival and recovery of viable Candida albicans organisms from the kidney and spleen. One-month-old mice were placed on one of five diets with varying nucleotide content. The results show that mice maintained on a nucleotide-free diet (NF) exhibit a significantly decreased mean survival time and a significantly increased viable organism recovery in the spleen following intravenous injection of graded inocula of C. albicans compared to mice fed diets containing RNA or uracil as a nucleotide source.
Fanslow
W C
WC
Department of Biochemistry, Rice University, Houston, Texas.
Kulkarni
A D
AD
Van Buren
C T
CT
Rudolph
F B
FB
D000818:Animals; D002176:Candida albicans / Q000302:isolation & purification; D002177:Candidiasis / Q000276:immunology* / Q000382:microbiology / Q000401:mortality; D005526:Food, Formulated; D005527:Food, Fortified; D007111:Immunity, Cellular / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D007668:Kidney / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D009711:Nucleotides / Q000008:administration & dosage / Q000494:pharmacology*; D013154:Spleen / Q000382:microbiology
D009711:Nucleotides