Cytotoxicity and effects of T2-toxin on plasma proteins involved in coagulation, fibrinolysis and kallikrein-kinin system.
The activity of both the coagulation and fibrinolytic systems was markedly depressed 24 h after a sublethal dose of T-2 toxin. T-2 toxin was active as an anticoagulant at low doses, which did not affect the basal state of the animals. The kallikrein-kinin system was also affected by depletion of the prekallikrein, which indicates increased bradykinin levels in plasma. At the same time there was an increased activity of some clinically relevant enzymes in serum, indicating tissue injuries caused by T-2 toxin. All effects observed in this study reached their maximum within 24 h after administration, which corresponds to the time animals usually die when receiving a lethal dose. T-2 toxin does not, however, seem to affect the protease enzymes by reduced protein synthesis, because of early onset of the effects, nor does it act as a trigger itself. The effect of T-2 toxin on plasma protease enzymes is probably secondary to cytotoxic effects in the vascular endothelium.
Johnsen
H
H
Norwegian Defence Research Establishment, Division for Environmental Toxicology, Kjeller, Norway.
Odden
E
E
Johnsen
B A
BA
Bøyum
A
A
Amundsen
E
E
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D007610:Kallikreins / Q000097:blood*; D007705:Kinins / Q000097:blood*; D051379:Mice; D010447:Peptide Hydrolases / Q000097:blood*; D012717:Sesquiterpenes / Q000633:toxicity*; D013605:T-2 Toxin / Q000633:toxicity*
D007705:Kinins; D012717:Sesquiterpenes; D010447:Peptide Hydrolases; D007610:Kallikreins; D013605:T-2 Toxin