Monoamine oxidase inhibitors: safety and efficacy issues.
Controversy has historically centered on the use of monoamine oxidase inhibitors (MAOI) in the treatment of depression because of safety and efficacy issues. Hypertensive crisis following ingestion of foods containing tyramine is the most feared problem associated with MAOI therapy. The authors conclude that only four tyramine-containing foods clearly warrant absolute prohibition, but indicate situations where moderation should apply. Although MAOI remain second-line agents in the treatment of endogenous depression, it is unclear whether MAOI or tricyclic antidepressants should be the drugs of choice in atypical depression and this question necessitates future research.
Brown
C S
CS
Department of Clinical Pharmacy, University of Tennessee, Memphis 38163.
Bryant
S G
SG
D003866:Depressive Disorder / Q000188:drug therapy; D004032:Diet; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
D008996:Monoamine Oxidase Inhibitors