[Correlation of the total activity of blood plasma renin with levels of active and inactive renin, angiotensinogen and angiotensin II under different functional loads in patients with hypertension].
Components of the renin-angiotensin system (plasma renin activity, total and inactive renin, angiotensinogen and angiotensin II) were examined in 90 patients with labile and stable essential hypertension before and after functional and pharmacologic tests. New data have been obtained on intrasystemic regulatory mechanisms of the pressor renin-angiotensin systems. Different patterns of plasma active and inactive renin variations in response to salt loading are demonstrated in patients with different "renin" variants of essential hypertension. Angiotensin II is shown to have a stimulating effect on angiotensinogen synthesis.
Ustinova
S E
SE
Uchitel'
I A
IA
Masenko
V P
VP
D000328:Adult; D000804:Angiotensin II / Q000097:blood*; D000808:Angiotensinogen / Q000097:blood*; D002216:Captopril / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion / Q000187:drug effects; D011433:Propranolol / Q000627:therapeutic use; D011458:Prostaglandins E / Q000494:pharmacology; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System / Q000187:drug effects; D012965:Sodium Chloride / Q000494:pharmacology; D013997:Time Factors
D011458:Prostaglandins E; D000808:Angiotensinogen; D000804:Angiotensin II; D012965:Sodium Chloride; D002216:Captopril; D011433:Propranolol; D012083:Renin
Sootnoshenie obshcheĭ aktivnosti renina plazmy krovi, soderzhaniia aktivnogo i neaktivnogo renina, angiotenzinogena i angiotenzina II pri razlichnykh funktsional'nykh nagruzkakh u bol'nykh gipertonicheskoĭ bolezn'iu.