title: Relapsing large cell immunoblastic lymphoma complicating well-differentiated lymphocytic lymphoma: a report of two cases showing prolonged survival with therapy.
abstract: Two patients presented with co-existing large cell immunoblastic and well-differentiated lymphocytic lymphomas. Prolonged remissions from the large cell lymphomas were achieved following intensive combination chemotherapy but both patients suffered relapses after many years. Previous reports have grouped such patients with those developing classical Richter's syndrome implying a uniformly poor prognosis. This report suggests that this is not the case. It was not possible with immunohistochemical stains to prove or disprove that these tumours had the same stem cell origins.
authors.affiliation: Department of Haematology/Oncology, St. James's Hospital, Dublin, Republic of Ireland.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kennedy
authors.forename: P A
authors.initials: PA
authors.lastname: Daly
authors.forename: E
authors.initials: E
authors.lastname: Lawlor
authors.forename: D S
authors.initials: DS
authors.lastname: O'Briain
mesh_terms: D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local