Effect of cholesterol-rich diet on the susceptibility of rodent malarial parasites to chloroquine chemotherapy.
Mice were fed a cholesterol-rich diet and then subsequently infected with chloroquine-sensitive strains of either Plasmodium berghei or P. chabaudi. Chloroquine therapy, which was started 24 hours post-infection and continued for 3-4 days, was significantly less effective in cholesterol-fed animals compared to controls. The consequences of these findings to the resistance of P. falciparum in man to chloroquine, are discussed.
Ginsburg
H
H
Department of Biological Chemistry, Hebrew University of Jerusalem, Israel.
Landau
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I
Baccam
D
D
D000818:Animals; D002738:Chloroquine / Q000627:therapeutic use*; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000494:pharmacology*; D004351:Drug Resistance; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D010962:Plasmodium berghei / Q000187:drug effects
D002791:Cholesterol, Dietary; D002738:Chloroquine