title: Prevalence of late-onset 11 beta-hydroxylase deficiency in hirsute patients.
abstract: Serum levels of 11-deoxycortisol were determined in 182 hirsute women. Three patients presented high basal 11-deoxycortisol levels and an exaggerated response of this steroid to ACTH stimulation. A fourth patient had normal basal 11-deoxycortisol but was hyperresponsive to ACTH stimulation. Therefore diagnosis of late-onset 11 beta-hydroxylase deficiency was made in 4 out of 182 hirsute women with a prevalence of 2.2% in the group studied. In these patients, clinical findings and other hormonal patterns were not different from those of other women suffering from hirsutism.
authors.affiliation: Cattedra di Endocrinologia, University of Palermo, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Carmina
authors.forename: G
authors.initials: G
authors.lastname: Malizia
authors.forename: M
authors.initials: M
authors.lastname: Pagano
authors.forename: A
authors.initials: A
authors.lastname: Janni
mesh_terms: D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital; D000328:Adult; D005260:Female; D006628:Hirsutism / Q000201:enzymology* / Q000453:epidemiology; D006801:Humans; D012802:Sicily; D013250:Steroid Hydroxylases / Q000172:deficiency*; D013997:Time Factors
chemical_list: D013250:Steroid Hydroxylases