[Hemochromatosis: the clinical picture, diagnosis and treatment].
A survey of literature data and the author's own observation of 18 patients with hemochromatosis (H) have shown that H is a polysyndrome disease. Men aged 35 to 60 suffer more frequently. Its most significant symptoms and syndromes are skin hyperpigmentation, hypersideremia, liver cirrhosis, diabetes, cardiomyopathy, and endocrinopathy. Three variants in a course of H--mild, average severe and severe (complicated)--were defined with regard to the duration of disease, a degree of morphofunctional changes and insufficiency of the affected organs. Intravital diagnosis of H was possible in clinical awareness and in the detection of hypersideremia and hemosiderin in liver and skin biopsy specimens. Multimodality therapy (blood-letting, desferal and insulin) promoted compensation of metabolic derangement, stabilization and even regression of disease.
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D000328:Adult; D003131:Combined Modality Therapy; D006432:Hemochromatosis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006486:Hemosiderosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012880:Skin Pigmentation; D013577:Syndrome
Gemokhromatoz: klinika, diagnostika i lechenie.