Resistance to infection with Eimeria vermiformis in mouse radiation chimeras is determined by donor bone-marrow cells.
The course of infection with Eimeria vermiformis was determined in BALB/b, BALB/c, and C57BL/10ScSn (B10) mice and in radiation chimeras prepared from the H-2-compatible BALB/b and B10 mice. The BALB strains, irrespective of H-2 haplotype, were resistant, the B10 mice were susceptible, and in the chimeras infection was characterized by the genotype of the donated bone-marrow cells and not by the phenotype of the recipient. Thus, the genetic control of relative resistance or susceptibility to infection with this parasite is expressed through bone-marrow-derived cells.
Joysey
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Houghton Laboratory, Institute for Animal Health, Huntingdon, United Kingdom.
Wakelin
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Rose
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D000818:Animals; D001853:Bone Marrow / Q000276:immunology*; D016026:Bone Marrow Transplantation; D003048:Coccidiosis / Q000235:genetics / Q000276:immunology*; D007111:Immunity, Cellular; D051379:Mice; D008815:Mice, Inbred Strains; D011828:Radiation Chimera; D013601:T-Lymphocytes / Q000276:immunology