[Insulin polyamino acid complexes--a variable principle in the preparation of sustained-release forms].
Polyglycine, polyalanine, polyleucine, poly-alpha-glutamic acid, poly-gamma-glutamic acid and poly-alpha-lysine were complexed with insulin under non denaturating conditions. The liberation behaviour of the hormone was investigated in vivo and in vitro in dependence of the insulin content, mole mass, ionic interaction and hydrophobicity of the polyamino acid. The in vitro results were mainly confirmed by animal experiments and indicated distinct effects of the physiochemical parameters to the bioavailability of insulin. The complex of poly-alpha-lysine and polyglycine were shown to be the most suited retard form, producing significant blood glucose lowering effects up to 12 hours.
Losse
G
G
Technische Universität Dresden, Sektion Chemie.
Raddatz
H
H
Naumann
W
W
Kossowicz
J
J
D000596:Amino Acids; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D007328:Insulin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008297:Male; D011817:Rabbits; D051381:Rats
D000596:Amino Acids; D001786:Blood Glucose; D003692:Delayed-Action Preparations; D007328:Insulin
Insulin-Polyaminosäure-Komplexe--ein variationsfähiges Prinzip zur Gewinnung von Verzögerungsformen.