Decreased production of IL-6 by peripheral blood mononuclear cells of patients with chronic lymphocytic leukemia and related disorders.
The present study has shown a decreased production of IL-6 by LPS-stimulated mononuclear cells of B-CLL blood. This decrease with attributed to an abnormality of either monocytes or T lymphocytes. A similar decrease was seen in HCL and NHL. Experiments with mixtures of normal and CLL cells suggest that the decreased IL-6 production in CLL is due neither to an inhibition of normal blood mononuclear cells IL-6 production by B-CLL lymphocytes nor to the absence in CLL blood of cell(s) or cytokine(s) needed for IL-6 production.
Stryckmans
P
P
Service de Médecine Interne, Université Libre de Bruxelles, Belgium.
Vandenplas
B
B
Dorval
C
C
Vandenbussche
P
P
Massy
M
M
Bernier
M
M
Content
J
J
D006801:Humans; D015850:Interleukin-6; D007378:Interleukins / Q000096:biosynthesis*; D007943:Leukemia, Hairy Cell / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism*
D015850:Interleukin-6; D007378:Interleukins; D008070:Lipopolysaccharides