title: Outer-membrane permeability to beta-lactam antibiotics in Yersinia enterocolitica.
abstract: Two outer-membrane (OM) proteins of Yersinia enterocolitica YOMP-C and YOMP-F appear to function as porins. Mutants that were YOMP-C- and YOMP-F- exhibited changes in cephaloridine and [3H]glucose uptake and increased resistance to beta-lactam antibiotics (especially cephalosporins) and tetracycline. Alterations in OM permeability may contribute to antibiotic resistance in Yersinia.
authors.affiliation: Institute of Microbiology, Warsaw University, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Brzostek
authors.forename: J
authors.initials: J
authors.lastname: Hrebenda
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D002463:Cell Membrane Permeability; D002511:Cephalosporins / Q000378:metabolism; D004352:Drug Resistance, Microbial; D009154:Mutation; D013753:Tetracycline Resistance; D015008:Yersinia enterocolitica / Q000378:metabolism*; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D002511:Cephalosporins; D001618:beta-Lactamases