The design and synthesis of mimetics of peptide beta-turns.
The synthesis of an 11 membered ring bis-lactam, a system which is designed as a conformationally restricted mimetic of type I and type II beta-turns is described. Computer assisted molecular modeling was used to compare the predicted low energy conformers of the turn mimetic with idealized type I and type II turn structures. Initial computational analysis indicates that the basic ring structure will provide an excellent foundation for the development of a varieity of beta-turn mimetics.
Kahn
M
M
University of Illinois, Department of Chemistry, Chicago 60680.
Wilke
S
S
Chen
B
B
Fujita
K
K
Lee
Y H
YH
Johnson
M E
ME
D015198:Designer Drugs; D010455:Peptides / Q000138:chemical synthesis; D011487:Protein Conformation; D047090:beta-Lactams
D015198:Designer Drugs; D010455:Peptides; D047090:beta-Lactams