title: Antimicrobial properties of topical anesthetic liquids containing lidocaine or benzocaine.
abstract: Six species of microorganisms commonly found within the oral cavity were exposed for either one minute or two hours to 5% lidocaine liquid topical anesthetic and benzocaine liquid topical anesthetic. Mixtures of microorganisms and anesthetics were diluted and plated onto a brain heart infusion medium. Reduction in cell viability was 73-100% after exposure to the anesthetic agents when compared with the saline/buffer controls. A significant reduction (p < .005) in cell growth by Streptococcus mutans, S. sanguis, S. mitis, S. salivarius, Actinomyces viscosus, and Candida albicans was associated with a one-minute and two-hour exposure to lidocaine, benzocaine, 5% lidocaine, and the benzocaine vehicle control. Five percent lidocaine reduced growth of the test orgainisms more than benzocaine in one-minute exposures to S. mutans, A. viscosus and S. salivarius and with a two-hour exposure to S. salivarius.Five percent lidocaine was bacteriocidal or fungicidal to all microorganisms for both time periods whereas, benzocaine liquid topical anesthetic was predominately bacteriostatic or fungistatic after one-minute exposures and bacteriocidal or fungicidal after two hours.The results indicated that two dental liquid topical anesthetics containing lidocaine or benzocaine possessed considerable antimicrobial activity to selected oral microorganisms. The exclusive use of a topical liquid anesthetic may be an adequate means to render the oral mucosa aseptic before injection of a local anesthetic.
authors.forename: M E
authors.initials: ME
authors.lastname: Morrow
authors.forename: C W
authors.initials: CW
authors.lastname: Berry
mesh_terms: D000190:Actinomyces / Q000187:drug effects; D000287:Administration, Topical; D000891:Anti-Infective Agents, Local; D001419:Bacteria / Q000187:drug effects*; D001566:Benzocaine / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D008012:Lidocaine / Q000494:pharmacology*; D013291:Streptococcus / Q000187:drug effects
chemical_list: D000891:Anti-Infective Agents, Local; D008012:Lidocaine; D001566:Benzocaine