Induction of tumour necrosis factor by staphylococcal toxic shock toxin 1.
Staphylococcal toxic shock syndrome toxin 1 (TSST1) induced the release of tumour necrosis factor (TNF) from human and rabbit monocytes in vitro. Nanogram amounts of TSST1 were sufficient to induce TNF release. There was considerable variation in response between cells from different rabbits and different donors. Rabbit monocytes were slightly more sensitive to TSST1 than were human monocytes. Release of TNF in vivo could explain many of the symptoms of toxic shock syndrome.
de Azavedo
J C
JC
Department of Microbiology, Trinity College, Dublin, Eire.
Drumm
A
A
Jupin
C
C
Parant
M
M
Alouf
J E
JE
Arbuthnott
J P
JP
D000328:Adult; D000818:Animals; D001427:Bacterial Toxins; D004768:Enterotoxins / Q000633:toxicity*; D006801:Humans; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000633:toxicity; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits; D012772:Shock, Septic / Q000209:etiology; D013045:Species Specificity; D013211:Staphylococcus aureus; D018089:Superantigens; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D001427:Bacterial Toxins; D004768:Enterotoxins; D008070:Lipopolysaccharides; D018089:Superantigens; D014409:Tumor Necrosis Factor-alpha; C030107:enterotoxin F, Staphylococcal