A new case of Creutzfeldt-Jakob disease associated with human growth hormone therapy in New Zealand.
A clinically atypical, neuropathologically verified case of Creutzfeldt-Jakob disease is described in a 32-year-old New Zealand woman with idiopathic hypopituitarism who had been treated in late adolescence (1970 to 1973) with human growth hormone processed from pooled cadaveric pituitary glands.
Croxson
M
M
Auckland Hospital, New Zealand.
Brown
P
P
Synek
B
B
Harrington
M G
MG
Frith
R
R
Clover
G
G
Wilson
J
J
Gajdusek
D C
DC
D000328:Adult; D000682:Amyloid / Q000302:isolation & purification; D001921:Brain / Q000473:pathology*; D001923:Brain Chemistry; D002531:Cerebellum / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D007562:Creutzfeldt-Jakob Syndrome / Q000209:etiology* / Q000473:pathology; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D013006:Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007018:Hypopituitarism / Q000188:drug therapy*; D009419:Nerve Tissue Proteins / Q000032:analysis
D000682:Amyloid; D002556:Cerebrospinal Fluid Proteins; D009419:Nerve Tissue Proteins; D013006:Growth Hormone