Serum selenium levels in diuretic-treated hypertensives: a double-blind trial of piretanide against hydrochlorothiazide plus amiloride.
In a double-blind parallel group study carried out on 47 patients with mild to moderate essential hypertension, the effects of 6 mg piretanide once or twice daily on serum selenium levels were compared with 50 mg hydrochlorothiazide plus 5 mg amiloride before treatment and after 6 and 12 weeks of treatment. Serum levels of the trace element, selenium, over a treatment period of 12 weeks remained unchanged in all three treatment groups, indicating that the selenium homeostasis is not disturbed during a treatment period of three months with either piretanide or a potassium sparer/thiazide-diuretic combination.
Verho
M
M
Clinical Research, Hoechst AG, Frankfurt am Main, Federal Republic of Germany.
Bossaller
W
W
Malerczyk
V
V
D000328:Adult; D000368:Aged; D000584:Amiloride / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D011897:Random Allocation; D012643:Selenium / Q000097:blood*; D013449:Sulfonamides / Q000627:therapeutic use*
D004232:Diuretics; D013449:Sulfonamides; D006852:Hydrochlorothiazide; D000584:Amiloride; C015451:piretanide; D012643:Selenium