title: Malignancy arising in endometriosis associated with unopposed estrogen replacement.
abstract: Malignant transformation of endometriosis is a well documented phenomenon. Although it occurs most commonly in the ovaries, there have been approximately 50 reported cases of extraovarian malignant transformation of endometriosis. This paper presents two cases of malignancy arising from a dormant focus of endometriosis after total abdominal hysterectomy, bilateral salpingo-oophorectomy, and exogenous estrogen replacement therapy. These malignancies are often well differentiated and may behave similarly to estrogen-induced endometrial carcinomas. After surgical castration of a premenopausal woman with endometriosis, the use of progestins in replacement therapy may reduce the risk of malignancy arising in endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, University of California at Los Angeles School of Medicine.
authors.forename: C
authors.initials: C
authors.lastname: Reimnitz
authors.forename: E
authors.initials: E
authors.lastname: Brand
authors.forename: R K
authors.initials: RK
authors.lastname: Nieberg
authors.forename: N F
authors.initials: NF
authors.lastname: Hacker
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced*; D003131:Combined Modality Therapy; D004715:Endometriosis / Q000188:drug therapy* / Q000601:surgery; D004967:Estrogens / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000139:chemically induced* / Q000188:drug therapy / Q000601:surgery
chemical_list: D004967:Estrogens