title: Urinary thromboxane B2 as an indicator of acute rejection in lung allotransplantation.
abstract: The behavior of urinary thromboxane B2 (TXB2) during acute rejection of lung allotransplants was evaluated. Unmatched mongrel dogs were submitted to a left lung orthotopic allotransplantation (groups I and II), or a sham operation (group III). All animals had an initial significant elevation of TXB2 excretion due to surgical trauma; however, in sham-operated animals (group III) this elevation returned to basal levels after 3 days. All transplanted animals (groups I and II) had persistent TXB2 elevation with 2 important peaks on postop days 5 and 9. The elevated TXB2 excretion persisted in spite of immunosuppressive treatment with azathioprine and prednisone (group II). Rejection was followed by means of an objective grading system applied to chest roentgenograms taken on all animals. It was found that TXB2 levels correlated directly with the grade of radiographic changes seen, thus indicating degree of rejection. TXB2 can be useful as a noninvasive indicator for surveillance of lung allograft rejection.
authors.affiliation: Instituto Nacional de Enfermedades Respiratorias, Department of Experimental Surgery, Tlalpan, Mexico.
authors.forename: P
authors.initials: P
authors.lastname: Santillan-Doherty
authors.forename: A
authors.initials: A
authors.lastname: Odor-Morales
authors.forename: R
authors.initials: R
authors.lastname: Jasso-Victoria
authors.forename: M
authors.initials: M
authors.lastname: Selman
authors.forename: M
authors.initials: M
authors.lastname: Gaxiola
authors.forename: R
authors.initials: R
authors.lastname: Lopez-Medrano
authors.forename: S
authors.initials: S
authors.lastname: Chavira-Estefan
authors.forename: C
authors.initials: C
authors.lastname: de la Rosa-Laris
authors.forename: J
authors.initials: J
authors.lastname: Villalba-Caloca
mesh_terms: D000818:Animals; D004285:Dogs; D006084:Graft Rejection; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D016040:Lung Transplantation; D011859:Radiography; D013929:Thromboxane B2 / Q000652:urine*; D013997:Time Factors
chemical_list: D013929:Thromboxane B2