Hepatic carbohydrate metabolism in rats bred for alcohol preference.
The influence of ethanol on the carbohydrate metabolism was studied in two strains of rats: the AA strain with an inherited preference for alcohol and the ANA strain with an aversion to alcohol. In both strains, a single intraperitoneal dose of ethanol (1.5 g/kg body wt.) slightly increased the blood glucose concentration. In AA rats alcohol increased the rate of gluconeogenesis from alanine and had no effect on the liver glycogen stores, whereas in ANA rats the rate of gluconeogenesis remained unchanged and the glycogen stores decreased. It thus appears that the two rat strains maintain their blood glucose concentration by different mechanisms; the ANA rats utilise both glycogenolysis and gluconeogenesis but the AA rats only gluconeogenesis.
Forsander
O A
OA
Research Laboratories of the Finnish State Alcohol Company (Alko Ltd.), Helsinki.
Pösö
A R
AR
D000409:Alanine / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D050260:Carbohydrate Metabolism; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D005518:Food Preferences; D005934:Glucagon / Q000097:blood; D005943:Gluconeogenesis / Q000187:drug effects; D007328:Insulin / Q000097:blood; D008099:Liver / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D008112:Liver Glycogen; D000431:Ethanol; D005934:Glucagon; D000409:Alanine