Atypical membranous glomerulonephritis with fibrillar subepithelial deposits in a patient with malignant lymphoma.
A 61-year-old male treated for a malignant lymphoma developed a nephrotic syndrome. Renal biopsy revealed an atypical form of membranous glomerulonephritis whereby the epimembranous deposits were of fibrillar configuration. Immunoglobulin, kappa light chains and complement were demonstrated in a granular pattern. It is suggested that the fibrillar deposits represent an abnormal structural configuration of immune complex deposits.
Rosenmann
E
E
Department of Pathology, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Que., Canada.
Brisson
M L
ML
Bercovitch
D D
DD
Rosenberg
A
A
D005455:Fluorescent Antibody Technique; D005920:Glomerular Mesangium / Q000648:ultrastructure; D005921:Glomerulonephritis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000648:ultrastructure; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000473:pathology