title: [Changes in metabolism of the nervous system in exposure to ionizing radiation at supralethal doses].
abstract: Some biochemical disorders in the animals' central nervous system mainly in brain have been analysed after the exposure to superlethal doses of ionizing radiation as well in a state of the so-called early transient incapacity. The metabolism of gamma-aminobutyric acid, ammonia, histamine, cyclic nucleotides, prostaglandins and other biologically active substances is compared. Their investigation as metabolic regulators and modulators for nerve tissue seems to be of particular importance for deciphering the molecular mechanisms of changes in the central nervous system functional state and for discovering the possibility of its maintaining at a given level of activity.
authors.forename: T I
authors.initials: TI
authors.lastname: Sokolova
authors.forename: E F
authors.initials: EF
authors.lastname: Romantsev
mesh_terms: D000641:Ammonia / Q000378:metabolism / Q000528:radiation effects; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000528:radiation effects; D006632:Histamine / Q000378:metabolism / Q000528:radiation effects; D009420:Nervous System / Q000378:metabolism / Q000528:radiation effects*; D009712:Nucleotides, Cyclic / Q000378:metabolism / Q000528:radiation effects; D011453:Prostaglandins / Q000378:metabolism / Q000528:radiation effects; D011829:Radiation Dosage; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000528:radiation effects
chemical_list: D009712:Nucleotides, Cyclic; D011453:Prostaglandins; D005680:gamma-Aminobutyric Acid; D000641:Ammonia; D006632:Histamine
vernacular_title: Izmeneniia metabolizma nervnoĭ sistemy pri deĭstvii ioniziruiushcheĭ radiatsii v sverkhletal'nykh dozakh.