title: Physiology and pathophysiology of gastrin: a review.
abstract: Recent advances in understanding the physiology and pathophysiology of the gastrointestinal hormone, gastrin, are reviewed. Details of gastrin biosynthesis, secretion, and cellular actions may have broad implications for other peptide hormones. Potentially useful antigastrin drugs are described. Areas of future development are suggested.
authors.affiliation: Department of Surgery, University of Washington, Seattle 98195.
authors.forename: M W
authors.initials: MW
authors.lastname: Mulholland
authors.forename: H T
authors.initials: HT
authors.lastname: Debas
mesh_terms: D004261:DNA Replication / Q000187:drug effects; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000254:growth & development; D005755:Gastrins / Q000096:biosynthesis / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D010437:Peptic Ulcer / Q000378:metabolism; D011964:Receptors, Gastrointestinal Hormone / Q000378:metabolism; D013274:Stomach Neoplasms / Q000378:metabolism; D014628:Vagotomy; D015043:Zollinger-Ellison Syndrome / Q000378:metabolism
chemical_list: D005755:Gastrins; D011964:Receptors, Gastrointestinal Hormone