title: Altered tissue content of trace metals in diabetic hyperinsulinaemic sand rats (Psammomys obesus).
abstract: The concentrations of zinc, copper, and chromium in liver, kidney, muscle, bone and serum from control normoinsulinaemic and hyperinsulinaemic sand rats (Psammomys obesus) and from untreated spontaneously hyperinsulinaemic-hyperglycaemic sand rats were compared. A chronic hyperinsulinaemic-hyperglycaemic state was associated with a significant reduction (p less than 0.01) of zinc concentration in the liver, kidney and muscle but an elevation of zinc content in bone and of chromium in the liver. A hyperinsulinaemic-nor-moglycaemic state was not associated with similar changes in zinc concentration in the liver, kidney, muscle and bone. We conclude that in hyperinsulinaemic-hyperglycaemic sand rats there is a tendency to zinc depletion in several tissues. This depletion is not solely the result of a hyperinsulinaemic state but may be related to accompanying hyperglycaemia.
authors.affiliation: Department of Medicine B, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Raz
authors.forename: J H
authors.initials: JH
authors.lastname: Adler
authors.forename: E
authors.initials: E
authors.lastname: Havivi
mesh_terms: D000818:Animals; D003411:Arvicolinae / Q000378:metabolism*; D001842:Bone and Bones / Q000032:analysis; D002857:Chromium / Q000032:analysis; D003300:Copper / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004195:Disease Models, Animal; D006946:Hyperinsulinism / Q000378:metabolism*; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D009132:Muscles / Q000032:analysis; D012016:Reference Values; D014131:Trace Elements / Q000032:analysis* / Q000097:blood; D015032:Zinc / Q000032:analysis
chemical_list: D014131:Trace Elements; D002857:Chromium; D003300:Copper; D015032:Zinc