Genotoxicity assessment of the plasmacytomagenic agent pristane (2.6.10.14-tetramethylpentadecane) and four related alkanes by the SOS chromotest.
The most extensively studied model of plasmacytomagenesis is the induction of plasmacytomas in BALB/c mice by i.p. injections of mineral oil or, chemically more defined, by several branched alkanes such as pristane (2.6.10.14-tetramethylpentadecane), phytane (2.6.10.14-tetramethylhexadecane), and 7-n-hexyloctadecane. The available evidence suggests that the primary biologic action of these plasmacytomagenic agents is to induce the formation of a chronic granulomatous tissue, the histological matrix of plasmacytoma development. However, certain genotoxic effects caused by the presence of these substances can not be ruled out a priori. Pristane, 2-methyldodecane, and 1.3-di-tert-butyl-5-methyl-cyclohexane as well as perhydroanthracene and hexahydrodibenzsuberane were proofed as potential genotoxic agents by the SOS chromotest, a quantitative bacterial colorimetric assay for genotoxins. The substances tested did not express any sign of genotoxicity, but exerted toxic effects to the E. coli tester strain.
Janz
S
S
Institute of Clinical Immunology, Karl-Marx-University, Leipzig, G.D.R.
Huttunen
T
T
Herzschuh
R
R
Storch
H
H
D000473:Alkanes / Q000633:toxicity; D000873:Anthracenes / Q000633:toxicity; D002273:Carcinogens; D003508:Cycloheptanes / Q000633:toxicity; D003510:Cyclohexanes / Q000633:toxicity; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D009152:Mutagenicity Tests; D010954:Plasmacytoma / Q000139:chemically induced; D013014:SOS Response, Genetics / Q000187:drug effects*; D013729:Terpenes / Q000633:toxicity*
D000473:Alkanes; D000873:Anthracenes; D002273:Carcinogens; D003508:Cycloheptanes; D003510:Cyclohexanes; D013729:Terpenes; C056115:1,3-di-tert-butyl-5-methylcyclohexane; C009042:pristane; C056113:perhydroanthracene; C056114:hexahydrodibenzsuberane; C056117:2-methyldodecane