A novel method to study directed cell migration in culture.
Directional migration of gingival fibroblasts was elicited in a cell culture system using reconstituted type I collagen fibers as a source of the putative chemoattractant. The rate of migration was expressed as Migration Index which turned out to be dependent on and directly related to the distance between the cells and the collagen. It is believed that this method enables one to study many different phenomena associated with extracellular matrix and cell interactions.
Yaffe
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Department of Oral Rehabilitation, Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem, Israel.
Shoshan
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S
D000818:Animals; D002465:Cell Movement; D002478:Cells, Cultured; D002633:Chemotaxis; D003094:Collagen; D003584:Cytological Techniques; D004285:Dogs; D005347:Fibroblasts / Q000166:cytology*; D005881:Gingiva / Q000166:cytology; D008722:Methods
D003094:Collagen