Yohimbine increases plasma insulin concentrations and reverses xylazine-induced hypoinsulinemia in dogs.
Xylazine (1.1 mg/kg of body weight, IV), an alpha 2-adrenoreceptor agonist, suppressed the increase in plasma insulin concentration induced by glucose (0.6 g/kg, IV) in dogs. Yohimbine (0.11 mg/kg, IV), an alpha 2-adrenoreceptor antagonist, given 5 minutes after xylazine, reversed effects of xylazine, whereas yohimbine alone increased plasma insulin and decreased plasma glucose concentrations. Seemingly, alpha 2-adrenoreceptors exert a negative control of insulin release.
Hsu
W H
WH
Department of Veterinary Physiology and Pharmacology, Iowa State University, Ames 50011.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004285:Dogs / Q000097:blood*; D005260:Female; D007328:Insulin / Q000097:blood*; D008297:Male; D013843:Thiazines / Q000037:antagonists & inhibitors*; D014991:Xylazine / Q000037:antagonists & inhibitors*; D015016:Yohimbine / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D013843:Thiazines; D014991:Xylazine; D015016:Yohimbine