Estrogen-progesterone treatment of Osler-Weber-Rendu disease.
A 56-year-old woman with Osler-Weber-Rendu disease had longstanding iron deficiency anemia from recurrent melena. Since neither laser photocoagulation nor surgery were successful in stopping the increasing transfusion need, combined estrogen-progesterone therapy was started. Except for slight bleeding from a temporary ileostomy, the bleeding and need for transfusion terminated promptly. This experience confirms that estrogen-progesterone therapy may promote cessation of bleeding gastrointestinal telangiectasias and indicates the need for controlled investigations.
Van Cutsem
E
E
Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium.
Rutgeerts
P
P
Geboes
K
K
Van Gompel
F
F
Vantrappen
G
G
D045166:Estradiol Congeners / Q000627:therapeutic use*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D011374:Progesterone / Q000627:therapeutic use*; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000150:complications / Q000188:drug therapy*
D045166:Estradiol Congeners; D011374:Progesterone