Synthesis of interleukin-1-like activity by normal rat chondrocytes in culture.
Chondrocytes prepared from the articular cartilage of young rats synthesize and secrete an interleukin-1-like activity into the medium. The physical and biochemical properties of this IL-1-like activity are similar to macrophage-derived IL-1. Immunological studies suggest that this activity is related to IL-1 alpha. Isolated chondrocytes and those grown in culture can express Ia.
Rath
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NC
Department of Inflammation and Immunology, American Cyanamid Company, Lederle Laboratories Division, Pearl River, New York 10965.
Oronsky
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AL
Kerwar
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D000818:Animals; D001681:Biological Assay; D002358:Cartilage, Articular / Q000166:cytology / Q000378:metabolism*; D002478:Cells, Cultured; D007158:Immunologic Techniques; D007375:Interleukin-1 / Q000096:biosynthesis*; D051381:Rats; D013997:Time Factors
D007375:Interleukin-1