Evidence that leukocyte function-associated antigen-1 is involved in recirculation and homing of human lymphocytes via high endothelial venules.
We report the results of mAb inhibition studies of human lymphocyte-high endothelial venule interaction in vitro. These studies in which T cells from both normal donors and from a LFA-1-deficient patient were used indicate that in addition to a system of organ-specific 90-kDa "homing" receptors on lymphocytes, LFA-1 is also involved in lymphocyte recirculation and homing.
Pals
S T
ST
Department of Pathology, Free University, Amsterdam, The Netherlands.
den Otter
A
A
Miedema
F
F
Kabel
P
P
Keizer
G D
GD
Scheper
R J
RJ
Meijer
C J
CJ
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000172:deficiency / Q000276:immunology / Q000502:physiology*; D002448:Cell Adhesion; D002465:Cell Movement; D006801:Humans; D007231:Infant, Newborn; D016169:Lymphocyte Function-Associated Antigen-1; D009928:Organ Specificity; D013601:T-Lymphocytes / Q000502:physiology*; D014699:Venules
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D016169:Lymphocyte Function-Associated Antigen-1