[Clinical immunosorbents on a basis of polymeric matrices].
Immobilization of anti-IgE on space-network polymers containing aliphatic amino- and hydrazido groups as a way of producing clinical immunosorbents has been studied. Influence of active group concentration on the specific activity of the immobilized antibodies and sorption dynamics of IgE from plasma of patents are investigated. Immunosorbents can be sterilized by gamma-irradiation without any loss of capacity. It is shown that the immunosorbents can be reused after regeneration. Basing on the results obtained, acrylonitrile- divinylbenzene copolymer with hydrazido groups is considered as the most perspective for production of clinical immunosorbents.
Chuchalin
A G
AG
Gorchakov
V D
VD
Lebedin
Iu S
IuS
Avdiushkina
T V
TV
Sakodynskiĭ
K I
KI
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000302:isolation & purification; D000936:Antigen-Antibody Complex; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology / Q000302:isolation & purification; D007164:Immunosorbents; D011108:Polymers; D011817:Rabbits
D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D007164:Immunosorbents; D011108:Polymers; C026408:anti-IgE antibodies; D007073:Immunoglobulin E
Klinicheskie immunosorbenty na osnove polimernykh matrits.