Use of new beta-lactam antibiotics for surgical infections.
The availability of beta-lactam antibiotics with extended spectra of activity against organisms commonly seen in surgical infections suggests that aminoglycoside-based therapy is no longer needed for most such community-acquired infections. The primary problems with specific beta-lactams are lack of activity against Bacteroides species and variable activity against Pseudomonas aeruginosa and enterococci. The pharmacokinetic properties of the newer beta-lactams vary considerably. This variation suggests specific settings in which these properties may be taken advantage of to improve clinical outcome.
Solomkin
J S
JS
Department of Surgery, University of Cincinnati College of Medicine, Ohio.
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D006801:Humans; D013530:Surgical Wound Infection / Q000188:drug therapy*; D014946:Wound Infection / Q000188:drug therapy*; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams