title: Relationship between an activated N-ras oncogene and chromosomal abnormality during leukemic progression from myelodysplastic syndrome.
abstract: The relationship between chromosomal abnormality and oncogene activation was investigated during leukemic progression in two patients with myelodysplastic syndrome (MDS). Both patients had partial or complete deletion of chromosome 5 in metaphase cells obtained throughout the progression to leukemia. Analysis with specific oligonucleotide probes revealed that bone marrow cells containing an activated N-ras oncogene proliferated in a dominant manner during the process of leukemic conversion in both patients. These observations suggest that the chromosomal abnormality may precede activation of the N-ras gene in these patients, and that both the chromosomal abnormality and the activated N-ras oncogene contribute to the development of leukemia.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Hongo.
authors.forename: H
authors.initials: H
authors.lastname: Hirai
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: H
authors.initials: H
authors.lastname: Mizoguchi
authors.forename: H
authors.initials: H
authors.lastname: Mano
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: J
authors.initials: J
authors.lastname: Nishida
authors.forename: F
authors.initials: F
authors.lastname: Takaku
mesh_terms: D000208:Acute Disease; D000328:Adult; D000753:Anemia, Refractory / Q000235:genetics* / Q000473:pathology; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics* / Q000473:pathology; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras)
chemical_list: D011518:Proto-Oncogene Proteins; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)