T-2 toxin inhibits mitochondrial function in yeast.
T-2 toxin inhibits oxygen consumption of whole cells and purified mitochondria of Saccharomyces cerevisiae. Inhibition of mitochondrial respiration is not relieved by 2, 4-dinitrophenol, indicating that T-2 toxin inhibits mitochondrial function at the level of the electron transport chain. T-2 toxin inhibition of state 3 respiration (with succinate) is overcome by N, N, N', N'-tetramethyl-p-phenylenediamine, indicating inhibition of site II of the electron transport chain. T-2 toxin inhibits mitochondrial succinate dehydrogenase activity and increases mitochondrial NADH dehydrogenase activity.
Koshinsky
H
H
Department of Applied Microbiology and Food Service, University of Saskatchewan, Saskatoon, Canada.
Honour
S
S
Khachatourians
G
G
D019297:2,4-Dinitrophenol; D004140:Dinitrophenols / Q000494:pharmacology; D004579:Electron Transport; D007700:Kinetics; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D009245:NADH Dehydrogenase / Q000037:antagonists & inhibitors; D010101:Oxygen Consumption / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D012717:Sesquiterpenes / Q000494:pharmacology*; D013605:T-2 Toxin / Q000494:pharmacology*
D004140:Dinitrophenols; D012717:Sesquiterpenes; D009245:NADH Dehydrogenase; D013605:T-2 Toxin; D019297:2,4-Dinitrophenol