title: [Metastatic neuroblastoma: consolidation treatment with 2 courses of high-dose chemotherapy followed by a bone marrow autograft].
abstract: Among 62 children over 1 year of age at diagnosis who were treated for stage IV neuroblastoma, 33 entered remission after conventional therapy. They received high-dose chemotherapy and in vitro purged bone marrow transplantation as consolidation therapy. Fifteen patients received one course and 18 two courses. At present, 16/33 grafted patients are alive in CR with a median follow-up of 28 months. Toxicity of this regimen was tolerable. Under this treatment, actuarial disease free survival is improved compared with that observed under conventional therapy.
authors.affiliation: Institut Gustave-Roussy, Villejuif, France.
authors.forename: O
authors.initials: O
authors.lastname: Hartmann
authors.forename: E
authors.initials: E
authors.lastname: Benhamou
authors.forename: F
authors.initials: F
authors.lastname: Beaujean
authors.forename: C
authors.initials: C
authors.lastname: Kalifa
authors.forename: O
authors.initials: O
authors.lastname: Lejars
authors.forename: C
authors.initials: C
authors.lastname: Patte
authors.forename: C
authors.initials: C
authors.lastname: Behard
authors.forename: F
authors.initials: F
authors.lastname: Flamant
authors.forename: A
authors.initials: A
authors.lastname: Thyss
authors.forename: A
authors.initials: A
authors.lastname: Deville
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D002330:Carmustine / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000188:drug therapy / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D011379:Prognosis; D013713:Teniposide / Q000008:administration & dosage; D014182:Transplantation, Autologous
chemical_list: D013713:Teniposide; D008558:Melphalan; D002330:Carmustine
vernacular_title: Neuroblastomes métastatiques: traitement de consolidation par deux cures de chimiothérapie lourde suivies d'autogreffe médullaire.