Diuretics and hypertension in black adults.
A randomized controlled, single-blind trial was conducted to compare the effectiveness of a high-dose diuretic with a combination of a diuretic and metoprolol in black adults with hypertension. All subjects were first treated with 50 mg/d of hydrochlorothiazide for four weeks. Only subjects with a diastolic blood pressure of 95 mm Hg or higher at the end of this four-week period entered the randomized trial. We hypothesized that black patients with uncontrolled hypertension and low plasma renin activity on usual-dose hydrochlorothiazide therapy (ie, 50 mg/d) would respond better to higher doses of hydrochlorothiazide (ie, 100 to 150 mg/d) than to a usual-dose diuretic and metoprolol. Diuretic-metoprolol combination therapy was significantly more effective than high-dose diuretic therapy regardless of plasma renin status.
Hawkins
D W
DW
College of Pharmacy, University of Georgia, Athens.
Dieckmann
M R
MR
Horner
R D
RD
D000328:Adult; D044383:Black People; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage*; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008790:Metoprolol / Q000008:administration & dosage*; D011897:Random Allocation; D012083:Renin / Q000097:blood
D006852:Hydrochlorothiazide; D012083:Renin; D008790:Metoprolol