Killing of virus-induced thymic lymphoma cells obtained from primary and early transfers by activated macrophages.
Primary radiation leukemia virus-induced thymic lymphomas were susceptible to both stasis and lysis mediated by LPS-activated macrophages. During short in vitro cultivation the X-irradiation-induced lymphoma (PIR-2) cells were killed to the same extent (up to 99%) by LPS-activated macrophages as the RadLV lymphoma cells at effector:target ratios of 10:1 and 1:1. Since RadLV is not present in PIR-2 lymphoma cells, its presence is not required for susceptibility of the lymphoma cells to macrophage-mediated killing. Our data also disprove the assumption that artifacts of long-term cultivation in vitro are responsible for tumor susceptibility to cytostasis and cytolysis mediated by activated macrophages.
Boteach
D
D
Lautenberg Center for General and Tumor Immunology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Gallily
R
R
D000818:Animals; D005260:Female; D008223:Lymphoma / Q000209:etiology / Q000276:immunology*; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes; D013997:Time Factors; D014407:Tumor Cells, Cultured; D014412:Tumor Virus Infections / Q000276:immunology