Tribulin in post-traumatic stress disorder.
Tribulin (endogenous monoamine oxidase inhibitor/benzodiazepine receptor binding inhibitor) output was measured in the urine of 18 patients with post-traumatic stress disorder (PTSD) and 13 controls. The level of the two inhibitory activities was highly significantly correlated in the group as a whole. There was no difference between output of either inhibitor in patients and controls. However, when the PTSD group was subdivided according to various psychometric ratings, a pattern of output did emerge. Levels of both inhibitory activities were higher in agitated compared with non-agitated subjects, and lower in extroverts compared with introverts. This finding supports the view that tribulin output is raised in conditions of greater arousal.
Davidson
J
J
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina.
Glover
V
V
Clow
A
A
Kudler
H
H
Meador
K
K
Sandler
M
M
D001143:Arousal; D003130:Combat Disorders / Q000652:urine*; D005260:Female; D006801:Humans; D007510:Isatin; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000652:urine*; D013313:Stress Disorders, Post-Traumatic / Q000652:urine*
D008996:Monoamine Oxidase Inhibitors; D007510:Isatin; C039776:tribulin