The design of molecular hosts, guests, and their complexes.
The origins, definitions, tools, and guiding principles of host-guest chemistry are developed. Perching, nesting, and capsular complexes are exemplified through molecular model and crystal structure comparisons. The degree of preorganization of a host for binding is a central determinant of its binding power. Complementarity of binding site placement in host and guest is a central determinant of structural recognition in complexation. Examples are given of chiral recognition in complexation, of partial transacylase mimics, of caviplexes, and of a synthetic molecular cell.
Cram
D J
DJ
Department of Chemistry and Biochemistry, University of California, Los Angeles 90024.
D000215:Acylation; D001665:Binding Sites; D055598:Chemical Phenomena; D002621:Chemistry; D003460:Crystallization; D004798:Enzymes; D008956:Models, Chemical; D008958:Models, Molecular; D009696:Nucleic Acids; D013816:Thermodynamics
D004798:Enzymes; D009696:Nucleic Acids