Alpha-1-antitrypsin (Pi) types in multiple sclerosis and lack of interaction with immunoglobulin (Gm) markers.
Susceptibility to multiple sclerosis is thought to involve several genetic loci apart from the HLA region on chromosome 6. No Pi allotype nor phenotype was associated with the disease in 125 unrelated patients from the Grampian region of northeast Scotland. Despite a previously reported Gm-HLA association in this population there was no apparent interaction between Pi alleles and Gm type which influenced disease susceptibility.
Francis
D A
DA
Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
Klouda
P T
PT
Brazier
D M
DM
Batchelor
J R
JR
McDonald
W I
WI
Hern
J E
JE
D000483:Alleles; D005787:Gene Frequency; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics; D007074:Immunoglobulin G / Q000235:genetics; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology; D010641:Phenotype; D000515:alpha 1-Antitrypsin / Q000235:genetics*
D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D000515:alpha 1-Antitrypsin