title: Specific therapy in severe fetal intrauterine growth retardation: failure of prostacyclin.
abstract: Two case histories of severe, early onset intrauterine growth retardation are presented. Intravenous prostacyclin was administered in an attempt to promote fetal growth and thus prolong the pregnancy, but was unsuccessful and resulted in intrauterine death in each case. The possible reasons for the failure of this treatment and alternative therapeutic options are discussed.
authors.affiliation: Department of Obstetrics & Gynaecology, St George's Hospital Medical School, London.
authors.forename: S A
authors.initials: SA
authors.lastname: Steel
authors.forename: J M
authors.initials: JM
authors.lastname: Pearce
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D011464:Epoprostenol / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005317:Fetal Growth Retardation / Q000188:drug therapy*; D006801:Humans; D011247:Pregnancy
chemical_list: D011464:Epoprostenol