title: Increases of neuropeptide Y-like immunoreactivity in plasma during insulin-induced hypoglycemia in man.
abstract: Neuropeptide Y-like immunoreactivity (NPY-LI) in plasma during insulin-induced hypoglycemia was measured in 4 healthy male volunteers. Plasma NPY-LI increased from 167 +/- 11 pg/ml to 247 +/- 25 pg/ml 30 min after the administration of insulin (0.1 U/kg body weight IV), reached the maximum (296 +/- 6 pg/ml) 45 min after the insulin, and then decreased. These results suggest that NPY is released into the systemic circulation during insulin-induced hypoglycemia in man.
authors.affiliation: Second Department of Internal Medicine, Tohoku University School of Medicine, Miyagi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Mouri
authors.forename: O
authors.initials: O
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Itoi
authors.forename: M
authors.initials: M
authors.lastname: Sone
authors.forename: M
authors.initials: M
authors.lastname: Ohneda
authors.forename: M
authors.initials: M
authors.lastname: Nozuki
authors.forename: K
authors.initials: K
authors.lastname: Yoshinaga
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D006801:Humans; D007003:Hypoglycemia / Q000097:blood* / Q000139:chemically induced; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009478:Neuropeptide Y / Q000097:blood*; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D007328:Insulin; D009478:Neuropeptide Y