[Human epidermal growth factor (h-EGF) in gastric carcinomas].
Two hundred and twenty one gastric carcinomas were immunohistochemically stained for h-EGF and we examined the correlation between h-EGF immunoreactivities and histologic findings. Regarding macroscopic and histologic types, incidence of h-EGF immunoreactivities in infiltrating type and in poorly differentiated type was significantly higher than those in localized type and in differentiated type, respectively. In addition, h-EGF producing carcinomas showed high positive rate in prognostic serosal involvement and scirrhous type in stroma. Prognosis in patients with h-EGF producing tumors was poorer than that in those with h-EGF non-producing tumors, especially in stages II and III. These results suggest that h-EGF immunoreactivities serves as a biological marker of high malignancy.
Fushida
S
S
Second Department of Surgery, Kanazawa University of Medicine, Japan.
Yonemura
Y
Y
Sugiyama
K
K
Matsumoto
H
H
Kamata
T
T
Miwa
K
K
Miyazaki
I
I
D000230:Adenocarcinoma / Q000032:analysis / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D004815:Epidermal Growth Factor / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000032:analysis* / Q000473:pathology
D014408:Biomarkers, Tumor; D004815:Epidermal Growth Factor