Membranous nephropathy in a bone marrow transplant recipient.
A bone marrow transplant recipient is described who had development of nephrotic syndrome in association with chronic graft-versus-host disease (GVHD) and on cyclosporine (CsA) treatment withdrawal. Renal biopsy revealed a membranous glomerulonephritis (MG). The possible relationship between this autoimmune disorder, the immunological features of GVHD in experimental animals, and the influence of CsA is discussed.
Hiesse
C
C
Nephrology Department, University Paris-South, Hospital Paul Brousse, Villejuif, France.
Goldschmidt
E
E
Santelli
G
G
Charpentier
B
B
Machover
D
D
Fries
D
D
D000328:Adult; D001706:Biopsy; D016026:Bone Marrow Transplantation; D003524:Cyclosporins / Q000008:administration & dosage; D005921:Glomerulonephritis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000209:etiology / Q000473:pathology
D003524:Cyclosporins