Insulin action on brain microvessels; effect on alkaline phosphatase.
The effects of insulin on brain alkaline phosphatase activity have been examined. Insulin inhibited the activity of alkaline phosphatase on brain microvessels in in vitro experiments. The inhibition observed was of the non-competitive type. These observations indicate that the hormone is able to induce neurochemical modifications revealed in this case as changes in the phosphate transfer enzymes in brain microvessels.
Catalán
R E
RE
Departamento de Bioquímica y Biología Molecular, Centro de Biología Molecular (CSIC-UAM), Universidad Autónoma de Madrid, Spain.
Martínez
A M
AM
Aragonés
M D
MD
Miguel
B G
BG
Robles
A
A
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D002196:Capillaries / Q000187:drug effects / Q000201:enzymology; D002417:Cattle; D002540:Cerebral Cortex / Q000098:blood supply*; D002560:Cerebrovascular Circulation; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D008833:Microcirculation / Q000201:enzymology
D007328:Insulin; D000469:Alkaline Phosphatase