[Autoimmune hemolytic anemia during treatment with cyclosporin after liver transplantation].
Hemolytic anemia was observed in a 36 year-old liver transplant patient. The immunosuppressive regimen included cyclosporine A and prednisolone. Hemolysis appeared a few days after amoxicillin treatment. The presence of anti-D allo-antibodies, auto-antibodies active against erythrocytes, and an immuno-allergic phenomenon against erythrocytic membrane coated by cyclosporine was demonstrated. Increase of daily dose of prednisolone without modification of cyclosporine doses was followed by the disappearance of allo- and auto-sensitization. The role of amoxicillin in promoting these hemolytic phenomenons may be suggested.
Causse
X
X
Service d'hépatogastroentérologie, Hôpital E. Herriot, Lyon.
Meyer
F
F
Bergeret
A
A
Faure
J L
JL
Paliard
P
P
D000328:Adult; D000658:Amoxicillin / Q000009:adverse effects* / Q000276:immunology; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D016031:Liver Transplantation; D011183:Postoperative Complications / Q000517:prevention & control
D001323:Autoantibodies; D003524:Cyclosporins; D007518:Isoantibodies; D000658:Amoxicillin
Anémie hémolytique auto-immune au cours d'un traitement par la ciclosporine après transplantation hépatique.