Serum neutrophil chemotactic activity (NCA) during aspirin-induced bronchoconstriction.
In order to determine mast cell involvement in aspirin-induced bronchoconstriction, 16 aspirin-sensitive asthmatics and 18 control patients were studied for serum neutrophil chemotactic activity, using Nelsons method, before and after oral aspirin administration. A significant increase in NCA was observed in 6 aspirin-sensitive asthmatics during aspirin bronchoconstriction. In two persons the increase was lower. In the remaining 8 persons, no increase in NCA was observed during aspirin bronchoconstriction. None of the control patients exhibited an increase in NCA. The authors assume that, in some of the patients with aspirin-induced bronchoconstriction mast cells are really involved.
Grzelewska-Rzymowska
I
I
Department of Pneumonology and Allergology, Medical Academy of Lodź, Poland.
Szmidt
M
M
Rozniecki
J
J
Grzegorczyk
J
J
D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000097:blood / Q000139:chemically induced / Q000209:etiology; D001986:Bronchial Spasm / Q000097:blood / Q000139:chemically induced* / Q000276:immunology; D002630:Chemotactic Factors / Q000097:blood* / Q000378:metabolism; D002634:Chemotaxis, Leukocyte; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications; D016209:Interleukin-8; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D008875:Middle Aged; D009504:Neutrophils
D002630:Chemotactic Factors; D016209:Interleukin-8; D001241:Aspirin