title: A comparison of blood, crystalloid and oxygenated crystalloid cardioplegia solutions on myoglobin and creatine kinase release following cardiac surgery.
abstract: Oxygenated crystalloid cardioplegia was found not to produce better cardioprotection than blood or crystalloid cardioplegia, as assessed by myoglobin and creatine kinase MB (CPK-MB) isoenzyme, in patients undergoing coronary artery surgery. Myoglobin and CPK-MB levels were found to peak at 1 and 3 h, respectively, following release of the aortic cross-clamp. There was a good correlation between peak myoglobin and CPK-MB levels. CPK-MB of non-cardiac origin was found to represent a substantial proportion of total CPK-MB 4 h after the release of the aortic cross-clamp.
authors.affiliation: Department of Cardiothoracic Surgery, Northern General Hospital, Sheffield, UK.
authors.forename: S P
authors.initials: SP
authors.lastname: Gerrish
authors.forename: J J
authors.initials: JJ
authors.lastname: Goiti
authors.forename: J E
authors.initials: JE
authors.lastname: Hunsley
mesh_terms: D001769:Blood; D002314:Cardioplegic Solutions / Q000494:pharmacology*; D001026:Coronary Artery Bypass; D003402:Creatine Kinase / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism*; D009211:Myoglobin / Q000378:metabolism*; D010100:Oxygen / Q000494:pharmacology; D011184:Postoperative Period; D011188:Potassium / Q000494:pharmacology; D017680:Potassium Compounds; D011446:Prospective Studies
chemical_list: D002314:Cardioplegic Solutions; D007527:Isoenzymes; D009211:Myoglobin; D017680:Potassium Compounds; C018369:potassium cardioplegic solution; D003402:Creatine Kinase; D011188:Potassium; D010100:Oxygen