title: Hypothetical interpretation of the calcium paradox in renin secretion.
abstract: Most renin-positive cells of the preglomerular arteriole are intermediate in morphological appearence between smooth muscle cells and epithelioid cells. Intermediate cells contain, in addition to secretory granules, contractile proteins arranged as a sublemmal network. The paradoxical (inhibitory) role of calcium in renin secretion is explained, on the basis of these findings, by an increased tone of the sublemmal network; this might impair the preexocytotic access of renin granules to the cell membrane.
authors.affiliation: I. Physiologisches Institut, Universität Heidelberg, Federal Republic of Germany.
authors.forename: R
authors.initials: R
authors.lastname: Taugner
authors.forename: R
authors.initials: R
authors.lastname: Nobiling
authors.forename: R
authors.initials: R
authors.lastname: Metz
authors.forename: F
authors.initials: F
authors.lastname: Taugner
authors.forename: C
authors.initials: C
authors.lastname: Bührle
authors.forename: E
authors.initials: E
authors.lastname: Hackenthal
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D007668:Kidney / Q000098:blood supply / Q000201:enzymology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008954:Models, Biological; D051381:Rats; D012083:Renin / Q000378:metabolism*
chemical_list: D012083:Renin; D002118:Calcium