title: Studies on possible sulfadimethoxine toxicity to liver and liver drug metabolizing enzyme system of goats, quail and rats.
abstract: No significant increases in serum SDH, ALT and AST activities were observed in goats and rats receiving oral sulfadimethoxine at 5 times the therapeutic dose. The quail showed significantly higher activities of SDH and ALT when compared to control values. Moderate increases in liver microsomal cytochrome P-450 and aniline hydroxylase activity were observed in goats and quail but no appreciable change in benzphetamine N-demethylase activity was detected in any species. These results suggest a lack of hepatic toxicity of sulfadimethoxine to these species under the reported experimental conditions.
authors.affiliation: School of Veterinary Medicine, Tuskegee University, AL 36088.
authors.forename: R R
authors.initials: RR
authors.lastname: Dalvi
authors.forename: S J
authors.initials: SJ
authors.lastname: Trivedi
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology*; D003088:Colinus; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006041:Goats; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013045:Species Specificity; D013412:Sulfadimethoxine / Q000633:toxicity*
chemical_list: D011506:Proteins; D013412:Sulfadimethoxine; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D007064:L-Iditol 2-Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase