[Pathogenetic relationship between insulin resistance, insulin secretion and impaired glucose tolerance in patients with obesity].
The distribution of obese patients without diabetes based on the results of the oral glucose tolerance test (OGTT) made it possible to define 2 groups of patients: with normal (the 1st group) and disturbed (the 2nd group) OGTT. A moderate increase in the levels of insulin and C-peptide after GTT and almost unchanged sensitivity to insulin were observed in the 1st group. A considerable increase in the levels of insulin and C-peptide after glucose intake and a considerable decrease in the sensitivity to insulin were observed in the 2nd group. In obese patients with diabetes mellitus the levels of insulin and C-peptide after the GTT were significantly lower than those in the 1st and 2nd groups. A conclusion has been made that whereas certain stages of pathogenesis of diabetes mellitus in obesity are associated with hyperinsulinemia and GTT disorder, obvious diabetes mellitus is characterized by a decrease in secretory potentialities of the insular apparatus in parallel with glucose intolerance.
Abdurakhmanova
A M
AM
Kosovskiĭ
M I
MI
Rakhimov
N R
NR
Guliamov
T D
TD
D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D003920:Diabetes Mellitus / Q000209:etiology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007330:Insulin Antibodies / Q000032:analysis; D007333:Insulin Resistance; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D013997:Time Factors
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D007330:Insulin Antibodies
Patogeneticheskaia sviaz' mezhdu insulinrezistentnost'iu, sekretsieĭ insulina i narusheniem tolerantnosti k gliukoze u bol'nykh ozhireniem.