[Current problems and future perspectives in drug delivery systems for cancer therapy].
The current problems and future perspectives in DDS and targeting therapy for the treatment of cancer patients were reviewed on the basis of the following experimental data obtained in our laboratory. 1) IgG fractions isolated from the serum of a patient with systemic lupus erythematosus showed marked accumulation in cancer cells, indicating that certain serum IgGs may be useful as carriers of anticancer agents. 2) Lipid microspheres were also incorporated within cancer cells to enhance the anti-tumor activities of anti-cancer agents. In addition, this material may be applied for prevention of lymph node metastasis because of its lymphotrophic property. 3) Lipid microspheres including non-steroidal analgesics were quite effective for the management of cancerous pain, suggesting its efficacy as a DDS in this direction, besides its usefulness with anti-cancer agents.
Mizushima
Y
Y
1st Dept. of Internal Medicine, St. Marianna University, School of Medicine.
Shoji
Y
Y
Saotome
T
T
Yanagawa
A
A
Nakagawa
T
T
D000700:Analgesics / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D004337:Drug Carriers; D006801:Humans; D008055:Lipids; D008863:Microspheres
D000700:Analgesics; D000970:Antineoplastic Agents; D004337:Drug Carriers; D008055:Lipids