Hepatitis B and AIDS and the promise for their control by vaccines.
Human hepatitis B virus and human immunodeficiency virus (HIV), that causes AIDS, share attributes and possible evolutionary relationships. The specific requirements for inducing effective immunity against hepatitis B and HIV are discussed. Lessons learned in studies of hepatitis B and its vaccine may find application in creating a vaccine against HIV.
Hilleman
M R
MR
Merck Institute for Therapeutic Research, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486.
D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D000956:Antigens, Viral / Q000276:immunology; D005822:Genetic Vectors; D006678:HIV / Q000276:immunology*; D015488:HIV Antigens; D006511:Hepatitis B Antigens / Q000235:genetics / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D006801:Humans; D014614:Vaccines, Synthetic / Q000302:isolation & purification; D014759:Viral Envelope Proteins / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000302:isolation & purification*
D000956:Antigens, Viral; D015488:HIV Antigens; D006511:Hepatitis B Antigens; D014614:Vaccines, Synthetic; D014759:Viral Envelope Proteins; D014761:Viral Hepatitis Vaccines