Spontaneous chromosomal anomalies in lymphocytes from xeroderma pigmentosum. A study of ten patients.
A cytogenetic study of the lymphocytes from 6 classic and 4 variant forms of xeroderma pigmentosum is reported. This study performed on 978 R-banded metaphases shows that there is no specific chromosomal rearrangement in this disorder. In UDS-deficient forms, the rates of deletions, chromatid gaps and chromosome gaps are significantly increased. The preferential involvement of G-bands is discussed.
Aledo
R
R
Structure et Mutagenèse Chromosomiques, CNRS UA 620, Paris.
Avril
M F
MF
Dutrillaux
B
B
Aurias
A
A
D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D014178:Translocation, Genetic; D014983:Xeroderma Pigmentosum / Q000235:genetics*