title: Selectivity of CF and 5-fluorouracil: critical role of polyglutamylation.
authors.affiliation: Department of Biochemical and Clinical Pharmacology, St. Jude Children's Research Hospital, Memphis, TN 38101.
authors.forename: J A
authors.initials: JA
authors.lastname: Houghton
authors.forename: L G
authors.initials: LG
authors.lastname: Williams
authors.forename: S S
authors.initials: SS
authors.lastname: deGraaf
authors.forename: S
authors.initials: S
authors.lastname: Radparvar
authors.forename: I W
authors.initials: IW
authors.lastname: Wainer
authors.forename: J R
authors.initials: JR
authors.lastname: Rodman
authors.forename: P J
authors.initials: PJ
authors.lastname: Houghton
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000201:enzymology; D000818:Animals; D002460:Cell Line; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D005472:Fluorouracil / Q000627:therapeutic use*; D005492:Folic Acid / Q000031:analogs & derivatives*; D006801:Humans; D002955:Leucovorin / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051379:Mice; D009368:Neoplasm Transplantation; D011624:Pteroylpolyglutamic Acids / Q000378:metabolism*; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D014183:Transplantation, Heterologous
chemical_list: D011624:Pteroylpolyglutamic Acids; D005492:Folic Acid; D013940:Thymidylate Synthase; D002955:Leucovorin; D005472:Fluorouracil