title: Prospective study of the effects of ventilation tubes on hearing after radiotherapy for carcinoma of nasopharynx.
abstract: In patients with nasopharyngeal carcinoma, deafness sometimes occurs following radiotherapy. It is usually conductive, but may be sensorineural. Tinnitus is present frequently and usually is distressing. The role of ventilation tubes (grommets) in relieving these problems was assessed in a prospective randomized controlled trial of 115 patients. In the group with grommets, there was an improvement in hearing, with a reduction of the averaged air-bone gap (p less than .01). This was not found in the control group without ventilation tubes, who developed a larger conductive loss (p less than .01) and, in addition, a slight deterioration of the averaged bone conduction threshold (p less than .01). Surprisingly, the group with grommets did not develop this sensorineural loss (p less than .01). In addition, tinnitus was improved significantly by the insertion of ventilation tubes (p less than .01). Neither necrosis nor stenosis of the external auditory meatus was found in either group.
authors.affiliation: Medical and Health Department Institute of Radiology & Oncology, Queen Elizabeth Hospital, Hong Kong.
authors.forename: C R
authors.initials: CR
authors.lastname: Chowdhury
authors.forename: J H
authors.initials: JH
authors.lastname: Ho
authors.forename: A
authors.initials: A
authors.lastname: Wright
authors.forename: S Y
authors.initials: SY
authors.lastname: Tsao
authors.forename: G K
authors.initials: GK
authors.lastname: Au
authors.forename: Y
authors.initials: Y
authors.lastname: Tung
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D006311:Hearing Disorders / Q000209:etiology / Q000517:prevention & control*; D006314:Hearing Loss, Conductive / Q000517:prevention & control; D006319:Hearing Loss, Sensorineural / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D008876:Middle Ear Ventilation; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D011446:Prospective Studies; D011832:Radiation Injuries / Q000517:prevention & control*; D014012:Tinnitus / Q000517:prevention & control