Pirenzepine as anti-inflammatory drug in a model of experimental colitis in rat.
Pirenzepine has been widely used for the treatment of gastric and duodenal ulcer. In this work we have proved that this drug could prevent the inflammatory reaction induced in the colon with an intraluminal stimuli as the acetic acid. These data suggest the cholinergic participation in the inflammatory colonic response.
Bustos-Fernández
L
L
Instituto de Gastroenterología, Dr. Jorge Pérez Companc, Pontificia Universidad Católica Argentina Santa María de los Buenos Aires.
González
E
E
Kofoed
J A
JA
Hamamura
S
S
Schiffrin
E
E
Celener
D
D
Ledesma de Paolo
M I
MI
D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D003092:Colitis / Q000188:drug therapy*; D003106:Colon / Q000378:metabolism*; D003108:Colonic Diseases / Q000188:drug therapy; D004487:Edema / Q000188:drug therapy; D008297:Male; D009093:Mucus / Q000378:metabolism*; D010890:Pirenzepine / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D010890:Pirenzepine; D019342:Acetic Acid