title: The main obstacle to a malaria vaccine: the malaria parasite.
abstract: The challenge to development of a malaria vaccine will be the variability of the sequences of target antigens. We discuss the variability in the T cell epitopes on the circumsporozoite protein of Plasmodium falciparum and the rapid selection of mutants after immunization with a protein from the asexual erythrocytic stage of P. knowlesi.
authors.affiliation: Laboratory of Parasitic Diseases, NIAID, Bethesda, MD 20892.
authors.forename: L H
authors.initials: LH
authors.lastname: Miller
authors.forename: M F
authors.initials: MF
authors.lastname: Good
mesh_terms: D000818:Animals; D000940:Antigenic Variation; D000953:Antigens, Protozoan / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D009154:Mutation; D010961:Plasmodium / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology; D015800:Protozoan Proteins; D013601:T-Lymphocytes / Q000276:immunology; D014612:Vaccines / Q000276:immunology*
chemical_list: D000953:Antigens, Protozoan; D000954:Antigens, Surface; D015800:Protozoan Proteins; D014612:Vaccines; C041595:circumsporozoite protein, Protozoan