title: [High-dose chemotherapy: principles, indications and complications].
abstract: Cure rates of children and adolescents with malignant diseases have improved since the introduction of systemic chemotherapy in cooperative trials in the recent 10 to 15 years. Tumors resistant to conventional doses have responded to high dose regimens. The rationale for the use of high dose regimens is discussed as well as adequate methods of protecting against severe and often lifethreatening complications.
authors.affiliation: Abteilung für Hämatologie und Onkologie, Zentrum für Kinderheilkunde der Universität Düsseldorf.
authors.forename: U
authors.initials: U
authors.lastname: Göbel
authors.forename: H
authors.initials: H
authors.lastname: Jürgens
authors.forename: D
authors.initials: D
authors.lastname: Schwamborn
authors.forename: V
authors.initials: V
authors.lastname: Wahn
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002648:Child; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Hochdosierte Chemotherapie: Grundlagen, Indikationen, Komplikationen.