Effect of captopril treatment on proteinuria in NZB/NZW F1 hybrid mice.
Oral treatment of female NZB/NZW F1 hybrid mice with captopril prevented the development of proteinuria and prolonged survival in mice demonstrating slight (trace to 1+) proteinuria. Captopril treatment also markedly reduced the incidence and magnitude of proteinuria and prevented death in mice showing significant (3+ or greater) proteinuria. Histopathological studies of the kidneys of treated mice further demonstrated improvements in the renal lesions of autoimmune mice. The mechanisms whereby captopril treatment influences the course of disease in NZB/NZW mice are not known.
Kurakata
S
S
Biological Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Fukami
M
M
Kitamura
K
K
D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D005260:Female; D007668:Kidney / Q000473:pathology; D051379:Mice; D008814:Mice, Inbred NZB; D011507:Proteinuria / Q000188:drug therapy* / Q000401:mortality
D002216:Captopril