title: Perioperative management of diabetic subjects. Subcutaneous versus intravenous insulin administration during glucose-potassium infusion.
abstract: The purpose of this study was to validate methods for the perioperative management of diabetic patients that meet the prerequisites of simplicity, applicability in the absence of a diabetologist, and flexibility, to rapidly meet changing metabolic requirements. The patients were divided into two groups that were comparable for age, sex distribution, type of diabetes, and type of surgical procedures. The results show that intravenous insulin administration achieved better glycemic control during the intraoperative period, whereas it did not offer advantages over the subcutaneous route during the pre- and postoperative periods. The satisfactory degree of steady glycemic control achieved and the absence of hypoglycemic episodes indicate that the separate administration of insulin and glucose plus electrolytes is an effective and safe management modality for diabetic patients undergoing major surgery.
authors.affiliation: Istituto di Clinica Medica Generale, Università degli Studi di Parma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pezzarossa
authors.forename: F
authors.initials: F
authors.lastname: Taddei
authors.forename: M C
authors.initials: MC
authors.lastname: Cimicchi
authors.forename: E
authors.initials: E
authors.lastname: Rossini
authors.forename: S
authors.initials: S
authors.lastname: Contini
authors.forename: E
authors.initials: E
authors.lastname: Bonora
authors.forename: A
authors.initials: A
authors.lastname: Gnudi
authors.forename: E
authors.initials: E
authors.lastname: Uggeri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage*; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011188:Potassium / Q000008:administration & dosage*; D011300:Preoperative Care; D013514:Surgical Procedures, Operative
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose; D011188:Potassium