Studies on possible sulfadimethoxine toxicity to liver and liver drug metabolizing enzyme system of goats, quail and rats.
No significant increases in serum SDH, ALT and AST activities were observed in goats and rats receiving oral sulfadimethoxine at 5 times the therapeutic dose. The quail showed significantly higher activities of SDH and ALT when compared to control values. Moderate increases in liver microsomal cytochrome P-450 and aniline hydroxylase activity were observed in goats and quail but no appreciable change in benzphetamine N-demethylase activity was detected in any species. These results suggest a lack of hepatic toxicity of sulfadimethoxine to these species under the reported experimental conditions.
Dalvi
R R
RR
School of Veterinary Medicine, Tuskegee University, AL 36088.
Trivedi
S J
SJ
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology*; D003088:Colinus; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006041:Goats; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013045:Species Specificity; D013412:Sulfadimethoxine / Q000633:toxicity*
D011506:Proteins; D013412:Sulfadimethoxine; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D007064:L-Iditol 2-Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase