title: Canine American cutaneous leishmaniasis: a clinical and immunological study in dogs naturally infected with Leishmania braziliensis braziliensis in an endemic area of Rio de Janeiro, Brazil.
abstract: Clinical and immunological findings from 35 dogs infected with Leishmania braziliensis braziliensis are described. The majority of the dogs had ulcerated single lesions on the ears. Sera from all infected dogs showed detectable Leishmania-induced antibodies using an indirect fluorescent antibody test. Antimonial therapy resulted in prompt healing of the lesions in 80.9% of the animals followed by a significant reduction in the anti-Leishmania antibody titers. However, treatment follow-up showed recurrences at the site of the primary lesion in 42.8% of the cases. These data were correlated with a persistence of the parasite in clinically healed lesions as well as with a negative intradermal test (leishmanin-delayed type hypersensitivity) observed in all animals but one.
authors.affiliation: Department of Immunology, WHO Collaborating Centre for Research, Training in the Immunology of Parasitic Diseases, Rio de Janeiro, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: Pirmez
authors.forename: S G
authors.initials: SG
authors.lastname: Coutinho
authors.forename: M C
authors.initials: MC
authors.lastname: Marzochi
authors.forename: M P
authors.initials: MP
authors.lastname: Nunes
authors.forename: G
authors.initials: G
authors.lastname: Grimaldi
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D000965:Antimony / Q000627:therapeutic use; D001938:Brazil; D004283:Dog Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D004285:Dogs; D005260:Female; D005455:Fluorescent Antibody Technique; D005500:Follow-Up Studies; D007892:Leishmania braziliensis / Q000276:immunology / Q000302:isolation & purification; D007897:Leishmaniasis, Mucocutaneous / Q000188:drug therapy / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D012882:Skin Tests / Q000662:veterinary
chemical_list: D000913:Antibodies, Protozoan; D000965:Antimony