Mortality in various intervention trials in elderly hypertensive patients: a review.
Results on total and cause-specific mortality from various randomized intervention trials on antihypertensive drug treatment in elderly hypertensives are reviewed, compared and pooled. Mortality from all causes tended to decrease in all trials, but this decrease was not statistically significant in any of the trials separately, nor when all results were pooled. When the results of all the trials were combined, there was a significant overall decrease in cardiovascular mortality of 28%. This decrease in cardiovascular mortality was mainly related to a significant reduction in cerebrovascular mortality of 41%. Mortality from coronary heart disease also tended to decrease by 28%, but statistical significance was not reached.
Staessen
J
J
Department of Pathophysiology, University of Leuven, Belgium.
Fagard
R
R
Van Hoof
R
R
Amery
A
A
D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001315:Australia; D002318:Cardiovascular Diseases / Q000401:mortality; D002986:Clinical Trials as Topic; D004739:England; D005060:Europe; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000401:mortality*; D007564:Japan; D008875:Middle Aged; D010349:Patient Compliance; D011897:Random Allocation; D012107:Research Design; D014852:Wales
D000959:Antihypertensive Agents