title: Soluble antigen of M. leprae coupled with liposomes elicits both "early" and "late" delayed hypersensitivity skin reactions.
abstract: The soluble antigen(s) of Mycobacterium leprae was(were) coupled to liposomes and used for skin testing of leprosy patients, hoping that this mode of antigen presentation would be identical to that of integral lepromin. The liposomized antigen(s) elicited both early (24-48 hr) and late (3-4 weeks) delayed-type hypersensitivity reactions, true to the nature of lepromin, unlike the soluble antigen(s) alone which elicit(s) only the early reaction.
authors.affiliation: Central JALMA Institute for Leprosy, Agra, India.
authors.forename: U
authors.initials: U
authors.lastname: Sengupta
authors.forename: S
authors.initials: S
authors.lastname: Sinha
authors.forename: G
authors.initials: G
authors.lastname: Ramu
authors.forename: R K
authors.initials: RK
authors.lastname: Lavania
authors.forename: C M
authors.initials: CM
authors.lastname: Gupta
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed; D007916:Lepromin / Q000276:immunology*; D008081:Liposomes; D009166:Mycobacterium leprae / Q000276:immunology*; D012882:Skin Tests
chemical_list: D000942:Antigens, Bacterial; D008081:Liposomes; C041383:leprosin A; D007916:Lepromin