Ankylosing spondylitis without B27: no evidence for gene conversion.
Isoelectric focusing gel electrophoresis was used to look for variant HLA molecules in five patients with HLA-B27 negative ankylosing spondylitis (AS). The isoelectric points of the HLA-A and B antigens from these patients and HLA paired controls were identical. This implies that the HLA-A and B antigens from the patients with AS and the controls are similar. Gene conversion of a nucleotide sequence from a B27 positive gene is thus unlikely to be the explanation for the existence of AS in patients who are HLA-B27 negative by alloantisera typing.
Pease
C T
CT
Department of Rheumatology, Westminster Hospital, London.
Ellis
S A
SA
McMichael
A J
AJ
Brewerton
D A
DA
D005260:Female; D005785:Gene Conversion; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis / Q000235:genetics*; D015796:HLA-B27 Antigen; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000276:immunology
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen