DNA synthesis in gametocytes of Plasmodium falciparum.
The DNA content of Plasmodium falciparum gametocytes during intra-erythrocytic development and during gametogenesis was established by cytophotometric methods. Intraerythrocytic micro- and macrogametocytes (Stage I-Stage VB) contain about twice the amount of DNA of haploid sporozoites and ringstages, indicating that DNA is synthesized during transformation of ringforms into Stage I gametocytes. Microgametocytes, after activation at pH 8, rapidly duplicate their genome several times, while the DNA content of macrogametocytes remains constant during gametogenesis.
Janse
C J
CJ
Department of Tropical Veterinary Medicine and Protozoology, University of Utrecht, The Netherlands.
Ponnudurai
T
T
Lensen
A H
AH
Meuwissen
J H
JH
Ramesar
J
J
Van der Ploeg
M
M
Overdulve
J P
JP
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D005718:Gametogenesis; D005796:Genes; D006238:Haploidy; D010963:Plasmodium falciparum / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*
D004247:DNA