title: [Acute leukemia with translocation (8;16)].
abstract: Three cases of M5 acute leukemia, 1 with a t(8;16)(p11;p13), 2 with variant translocations, both with a breakpoint at band 8p11, t(6;8)(q27;p11) and t(8;19)(p11;q13) are reported and 12 other published cases reviewed. This is a rare new entity, of variable but rather poor prognosis, seen from birth to 75 years of age, with several cases in infants. Leukemic cells, which often show conspicuous phagocytic activity on bone marrow smears, bear both monocytic and granulocytic markers in at least some cases. The best therapeutic regimen is not well-defined. The molecular basis of the disorder remains to be elucidated.
authors.affiliation: Centre de Recherches sur les Maladies du Sang, Centre Hospitalo-Universitaire, Poitiers, France.
authors.forename: J
authors.initials: J
authors.lastname: Tanzer
authors.forename: A
authors.initials: A
authors.lastname: Brizard
authors.forename: F
authors.initials: F
authors.lastname: Guilhot
authors.forename: E
authors.initials: E
authors.lastname: Benz-Lemoine
authors.forename: B
authors.initials: B
authors.lastname: Dreyfus
authors.forename: M
authors.initials: M
authors.lastname: Lessard
authors.forename: C
authors.initials: C
authors.lastname: Herchkovitch
authors.forename: H
authors.initials: H
authors.lastname: Mossafa
authors.forename: F
authors.initials: F
authors.lastname: Davi
authors.forename: J
authors.initials: J
authors.lastname: Huret
mesh_terms: D000328:Adult; D000368:Aged; D002885:Chromosomes, Human, Pair 16; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic
vernacular_title: La leucémie aiguë à translocation (8;16).