[Bronchial asthma combined with a congenital deficiency of alpha 1-proteinase inhibitor].
Some data on the determination of proteinase alpha 1-inhibitor phenotypes in children and adults with chronic non-specific pulmonary diseases were described. In pediatric patients the frequency of detection of heterozygotes PI MZ, PI MS did not exceed that in a healthy population whereas in adult patients heterozygotes were detected twice as more frequently. Among 149 adult patients one case of PI ZZ and one case of PI SS were detected. A patient with bronchial asthma had the MI ZZ phenotype. A possible frequency of the prevalence of PI ZZ phenotypes in a population and appropriateness of determination of blood levels and phenotypes of proteinase alpha 1-inhibitor in patients with bronchial asthma and other chronic nonspecific pulmonary diseases were considered.
Basis
V Iu
VIu
Shatkauskas
B A
BA
D000328:Adult; D001249:Asthma / Q000097:blood* / Q000235:genetics / Q000473:pathology; D001798:Blood Proteins / Q000032:analysis / Q000172:deficiency*; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000097:blood / Q000235:genetics; D010375:Pedigree; D010641:Phenotype; D011480:Protease Inhibitors / Q000097:blood / Q000172:deficiency*; D000515:alpha 1-Antitrypsin
D001798:Blood Proteins; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin
Bronkhial'naia astma v sochetanii s vrozhdennoĭ nedostatochnost'iu al'fa 1-ingibitora proteinaz.