title: Influence of joint inflammation on chondrocyte function.
abstract: Chondrocyte metabolism changes dramatically during joint inflammation. This overview summarizes the potential mechanisms underlying cartilage destruction in experimental arthritis models and provides arguments for a role for various inflammatory mediators. The contributions of both proteoglycan breakdown and impairment of chondrocyte function are discussed.
authors.affiliation: Department of Rheumatology, University Hospital St Radboud, Nijmegen, The Netherlands.
authors.forename: W B
authors.initials: WB
authors.lastname: van den Berg
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D002356:Cartilage / Q000187:drug effects / Q000473:pathology* / Q000502:physiology; D004195:Disease Models, Animal; D051379:Mice
chemical_list: D000941:Antigens