All three human ras genes are expressed in a wide range of tissues.
We examined the expression of the ras gene family (Ha-ras, Ki-ras, N-ras) in human fetal tissues (14 week) and in several human tumor cell lines. Dot blot hybridization showed that the three ras genes were expressed in all of the samples analysed, with a range of expression between 10 and 180 molecules/cell. There was no correlation between levels of expression of ras genes and the type of ras gene activated in different tumor types.
Fiorucci
G
G
Institute of Cancer Research, Royal Cancer Hospital, Chester Beatty Laboratories, London, U.K.
Hall
A
A
D004622:Embryo, Mammalian / Q000032:analysis; D006801:Humans; D009363:Neoplasm Proteins / Q000032:analysis; D009928:Organ Specificity; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D016283:Proto-Oncogene Proteins p21(ras); D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000032:analysis; D012334:RNA, Neoplasm / Q000032:analysis; D014407:Tumor Cells, Cultured / Q000032:analysis
D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)