title: Efficacy of defibrinogenation and steroid therapies on sudden deafness.
abstract: Effects of defibrinogenation therapy and steroid therapy for sudden deafness were compared by paired double-blind testing. The average hearing recovery for five frequencies (250 to 4000 Hz) was more than 30 dB; overall improvement rate was 57.3% (47/82) for the patients assigned to defibrinogenation therapy and 38.7% (31/80) for the patients assigned to steroid therapy. Thus, the former treatment resulted in significantly better hearing recovery.
authors.affiliation: Department of Otolaryngology, Osaka University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kubo
authors.forename: T
authors.initials: T
authors.lastname: Matsunaga
authors.forename: H
authors.initials: H
authors.lastname: Asai
authors.forename: K
authors.initials: K
authors.lastname: Kawamoto
authors.forename: J
authors.initials: J
authors.lastname: Kusakari
authors.forename: Y
authors.initials: Y
authors.lastname: Nomura
authors.forename: M
authors.initials: M
authors.lastname: Oda
authors.forename: N
authors.initials: N
authors.lastname: Yanagita
authors.forename: H
authors.initials: H
authors.lastname: Niwa
authors.forename: T
authors.initials: T
authors.lastname: Uemura
mesh_terms: D000284:Administration, Oral; D000328:Adult; D012103:Batroxobin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001623:Betamethasone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001809:Blood Viscosity; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D003639:Hearing Loss, Sudden / Q000097:blood / Q000628:therapy*; D006400:Hematocrit; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D012697:Serine Endopeptidases / Q000627:therapeutic use*
chemical_list: D005340:Fibrinogen; D001623:Betamethasone; D012103:Batroxobin; D012697:Serine Endopeptidases