title: Recent advances in laboratory tests for autoantibodies to thyrotropin receptor protein in Graves' disease.
abstract: Graves' disease is characterized by the presence of autoantibodies with variable reactivities to TSH receptor protein. These autoantibodies are heterogeneous in nature and may act as TSH agonists or infrequently as TSH antagonists (blocking antibodies). With new technical advances, it has become possible to quantitate these antibodies and their reactivities in clinical laboratories. Technical aspects of these assays and their clinical utility in the diagnosis and management of patients with Graves' disease are discussed.
authors.affiliation: Department of Immunopathology, Cleveland Clinic Foundation, Ohio.
authors.forename: M K
authors.initials: MK
authors.lastname: Gupta
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D001681:Biological Assay; D006111:Graves Disease / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D007457:Iodine Radioisotopes; D011869:Radioligand Assay; D011989:Receptors, Thyrotropin / Q000276:immunology*; D013972:Thyrotropin / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D007457:Iodine Radioisotopes; D011989:Receptors, Thyrotropin; D013972:Thyrotropin