title: Synovial macrophage response to aluminium oxide ceramic and cobalt-chrome alloy wear particles in rats.
abstract: The tissue response to intra-articular injection into rat knees of similar concentrations of sterile cobalt-chrome (Co-Cr) alloy and aluminium oxide (AL2O3) ceramic prosthesis wear particles was assessed at 1, 4 and 13 wk. A semiquantitative method of histological assessment showed a correlation between the numbers of particles and macrophage response in the tissues, and a difference in the response to different concentrations of Co-Cr particles. At 1 wk, the macrophage response to Co-Cr particles was significantly greater (p less than or equal to 0.01) than that to AL2O3 particles but no difference was detected at 4 and 13 wk. The difference may be due to necrosis of macrophages induced by Co-Cr particles.
authors.affiliation: Department of Pathology, University of Adelaide, Australia.
authors.forename: D W
authors.initials: DW
authors.lastname: Howie
authors.forename: B
authors.initials: B
authors.lastname: Vernon-Roberts
mesh_terms: D000535:Aluminum / Q000494:pharmacology*; D000537:Aluminum Oxide / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials; D002516:Ceramics; D002858:Chromium Alloys / Q000494:pharmacology*; D006622:Hip Prosthesis; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D013583:Synovial Membrane / Q000166:cytology* / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D002858:Chromium Alloys; D000535:Aluminum; D000537:Aluminum Oxide