title: Hepatic amyloidosis presenting as severe intrahepatic cholestasis: a case report and review of the literature.
abstract: Although hepatic involvement is common in all forms of amyloidosis, jaundice is infrequent and usually mild. We report a case of a 74-yr-old man with severe intrahepatic cholestasis and hepatic amyloid. The topography of amyloid deposition was unusual, in that deposits were confined predominantly to the portal tract. They appeared as a dense eosinophilic infiltrate that stained with congo red. A review of the English-language literature revealed only 18 prior patients with hepatic amyloid associated with severe intrahepatic cholestasis. The histology of only one of these patients showed a similar distribution of amyloid deposits.
authors.affiliation: Sarah C. Upham Division of Gastroenterology, New York Medical College, Valhalla.
authors.forename: M S
authors.initials: MS
authors.lastname: Hoffman
authors.forename: B E
authors.initials: BE
authors.lastname: Stein
authors.forename: M M
authors.initials: MM
authors.lastname: Davidian
authors.forename: W S
authors.initials: WS
authors.lastname: Rosenthal
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000150:complications* / Q000473:pathology; D002780:Cholestasis, Intrahepatic / Q000209:etiology*; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000473:pathology; D008297:Male