title: Glucose and lipid metabolism and insulin sensitivity in type 1 diabetes: the effect of guar gum.
abstract: The effect of guar gum on glucose and lipid metabolism and on body insulin sensitivity was examined in nine type 1 diabetic patients treated with continuous subcutaneous insulin infusion. The study was done in a randomized, double-blind, crossover fashion with either guar gum or a placebo added to the usual diet four times per day for 4 wk each. Blood glucose levels after breakfast and lunch and daily insulin requirements were significantly lower during the guar-gum than the placebo diet. After a 4-wk guar-gum supplementation, blood glucose response to a test meal was significantly reduced by guar gum compared with the placebo. Hemoglobin A1 (HbA1) and insulin sensitivity remained unchanged. Serum total cholesterol fell by 21% (p less than 0.025). Thus, guar gum can reduce postprandial blood glucose, insulin requirements, and serum total cholesterol levels in type 1 diabetic patients.
authors.affiliation: Department of Medicine, Helsinki University Hospital, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Ebeling
authors.forename: H
authors.initials: H
authors.lastname: Yki-Järvinen
authors.forename: A
authors.initials: A
authors.lastname: Aro
authors.forename: E
authors.initials: E
authors.lastname: Helve
authors.forename: M
authors.initials: M
authors.lastname: Sinisalo
authors.forename: V A
authors.initials: VA
authors.lastname: Koivisto
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000503:physiopathology; D004032:Diet; D005260:Female; D005502:Food; D005685:Galactans / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008351:Mannans / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D053149:Plant Gums
chemical_list: D001786:Blood Glucose; D005685:Galactans; D007328:Insulin; D008055:Lipids; D008351:Mannans; D053149:Plant Gums; C007894:guar gum; D005947:Glucose