Antibacterial activities of fluorovinyl- and chlorovinylglycine and several derived dipeptides.
The in vitro antibacterial activities of several halovinylglycine compounds and their L-norvalyl peptide derivatives are presented. The most potent of them, L-norvalyl-L-chlorovinylglycine, displayed good activity against gram-positive organisms, including methicillin-resistant Staphylococcus species. Chlorovinylglycine is an efficient inhibitor of alanine racemase, but the antibacterial activity of L-norvalyl-L-chlorovinylglycine may involve other physiological targets as well.
Patchett
A A
AA
Merck, Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065.
Taub
D
D
Weissberger
B
B
Valiant
M E
ME
Gadebusch
H
H
Thornberry
N A
NA
Bull
H G
HG
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003470:Culture Media; D003523:Cycloserine / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007700:Kinetics; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D003470:Culture Media; D004151:Dipeptides; C055749:fluorovinylglycine; C055748:chlorovinylglycine; D003523:Cycloserine; D005998:Glycine