Failure of intravenously infused spleen cells bearing a minor histoincompatibility to delay rejection of skin grafts bearing additional antigens.
Intravenous infusions of spleen cells bearing single minor H antigens have been shown to induce an antigen-specific prolongation of survival of subsequently applied skin grafts bearing the infused antigen. In this report it is shown that i.v. infusion of spleen cells bearing only H-Y as an alloantigen fails to prolong the survival of subsequently applied skin grafts bearing H-Y and additional H antigens. In contrast, others have shown that the i.v. infusion of alloantigen-bearing cells can inhibit DTH reactions, CTL generation, or organ allograft rejection directed against additional alloantigens, provided they are present in the challenge inoculum or graft together with the i.v.-infused antigens. Several possible reasons for the discrepancy between the results with skin grafts, and the results of others using different assays of responsiveness to H antigens are examined.
Johnson
L L
LL
Trudeau Institute, Inc., Saranac Lake, New York 12983.
D000818:Animals; D005260:Female; D006084:Graft Rejection; D006183:H-2 Antigens / Q000276:immunology; D006182:H-Y Antigen / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007165:Immunosuppression Therapy / Q000379:methods; D007519:Isoantigens / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008912:Minor Histocompatibility Loci; D016038:Skin Transplantation; D013154:Spleen / Q000276:immunology
D006183:H-2 Antigens; D006182:H-Y Antigen; D000949:Histocompatibility Antigens Class II; D007519:Isoantigens