title: [Endoscopic sclerotherapy and esophageal varices].
abstract: 60 consecutive patients underwent sclerotherapy for hemorrhage from ruptured esophageal varices. Sclerosis was always started within the first 48 hours. 12 patients (20%) died during initial hospitalization, but only 5 from recurrent bleeding. Of 48 survivors, 22 (46%) did not rebleed during a mean 18-month follow-up, whereas 26 (54%) had recurrences, 27 of these bleeding episodes occurred early (within 4 months) and 17 late (mean 16.5 months). Eradication of the varices was achieved in 29 patients (60%) with a mean of 6.2 sessions and within a mean of 6 months. Of these 48 patients 2 have been lost to follow-up, 25 (52%) are alive after a mean follow-up of 29 months, and 21 (44%) died (though only 2 from variceal bleeding). The survival curve (Kaplan-Meier) of these 60 bleeders is 45% and 37% at 2 and 4 years respectively. Sclerotherapy caused no death and only minor adverse effects. These results confirm those in the literature. We advocate endoscopic sclerosis as first choice in the treatment of ruptured esophageal varices.
authors.affiliation: Division de gastroentérologie et nutrition, Hôpital cantonal universitaire de Genève.
authors.forename: R
authors.initials: R
authors.lastname: Berclaz
authors.forename: R
authors.initials: R
authors.lastname: de Peyer
authors.forename: B
authors.initials: B
authors.lastname: Miazza
authors.forename: A
authors.initials: A
authors.lastname: Laszlo
authors.forename: M
authors.initials: M
authors.lastname: Cunningham
authors.forename: J P
authors.initials: JP
authors.lastname: Dederding
authors.forename: R
authors.initials: R
authors.lastname: Loup
authors.forename: E
authors.initials: E
authors.lastname: Loizeau
mesh_terms: D000328:Adult; D000368:Aged; D004932:Esophageal and Gastric Varices / Q000150:complications / Q000628:therapy*; D004945:Esophagoscopy; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012421:Rupture; D012597:Sclerosing Solutions / Q000008:administration & dosage*
chemical_list: D012597:Sclerosing Solutions
vernacular_title: Sclérose endoscopique et varices oesophagiennes.