The effect of various MAO-B inhibitors on rabbit arterial strip response to tyramine.
Studies on the response to tyramine of the rabbit pulmonal artery strip have revealed that several specific MAO-B inhibitors (TZ-650, J-580, AGN-1135, U-1424 MDL-72165 and Ro 16-6491) potentiated the responses in a dose-dependent manner, similarly as a semi-selective MAO-B inhibitor pargyline and a nonselective MAO inhibitor tranylcypromine did. Only (-)deprenyl inhibited the response. Thus the inhibition of noradrenaline-releasing effect of tyramine, a property favorable from the point of view of safety in clinical practice, is a specific feature of (-)deprenyl and not a more general characteristics of MAO-B inhibitors.
Abdorubo
A
A
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
Knoll
J
J
D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D011651:Pulmonary Artery / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits; D014439:Tyramine / Q000494:pharmacology*
D008996:Monoamine Oxidase Inhibitors; D009638:Norepinephrine; D014439:Tyramine