title: Mutagenicity of monochlorodibenzofurans detected in the environment.
abstract: Recently, monochlorodibenzofuran, which is formed by the reaction of dibenzofuran with residual chlorine, has been detected in tap water in one region of Japan. The mutagenicities of 1-, 2-, 3-, and 4-chlorodibenzofuran were tested using Salmonella typhimurium TA98 and TA100. 1-Chlorodibenzofuran and 4-chlorodibenzofuran proved to be practically non-mutagenic, while 2-chlorodibenzofuran was weakly mutagenic. Unlike these three isomers, 3-chlorodibenzofuran was markedly mutagenic, and the intensity of its mutagenicity in TA98 was about one-fifth and in TA100 about one-twentieth of that of benzo[a]pyrene.
authors.affiliation: Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Ando
authors.forename: Y
authors.initials: Y
authors.lastname: Ohta
mesh_terms: D001572:Benzofurans / Q000633:toxicity*; D001711:Biotransformation; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity; D007536:Isomerism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D001572:Benzofurans; D006843:Hydrocarbons, Chlorinated; D009153:Mutagens; D014873:Water Pollutants; D014874:Water Pollutants, Chemical