Decreased expression of HLA class II antigens on human uveal melanoma cells after in vivo X-ray irradiation.
In order to determine the presence of HLA antigens on human uveal melanomas, we tested anti-HLA monoclonal antibodies on tissue sections of these tumors. A great variety in expression of HLA class I and II antigens was present. A significantly lower expression of HLA class II antigens was present on uveal melanomas that had been irradiated before enucleation. These tumors lacked a lymphocytic infiltrate in comparison with nonirradiated tumors. These data suggest that radiotherapy affects expression of histocompatibility antigens on tumors.
Jager
M J
MJ
Department of Ophthalmology, University of Amsterdam, The Netherlands.
van der Pol
J P
JP
de Wolff-Rouendaal
D
D
de Jong
P T
PT
Ruiter
D J
DJ
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006681:HLA-D Antigens / Q000032:analysis / Q000528:radiation effects*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008545:Melanoma / Q000276:immunology* / Q000473:pathology / Q000532:radiotherapy; D008875:Middle Aged; D014604:Uveal Neoplasms / Q000276:immunology* / Q000473:pathology / Q000532:radiotherapy; D001613:beta 2-Microglobulin / Q000378:metabolism / Q000528:radiation effects
D000911:Antibodies, Monoclonal; D006680:HLA Antigens; D006681:HLA-D Antigens; D001613:beta 2-Microglobulin