title: [Nasal provocation using histamine. A comparison of threshold determination using 3 methods of rhinomanometry].
abstract: Three methods of rhinomanometry were compared with each other with respect to their ability to determine the histamine threshold (histamine concentration for a 100% increase of the initial total nasal resistance): the active anterior rhinomanometry (AAR), the active posterior rhinomanometry (APR) and the passive anterior rhinomanometry (PAR). Nasal challenge and consecutive measurement by the three methods of rhinomanometry were conducted in a group of 11 volunteers. The three methods gave significantly different histamine concentration thresholds (p = 0.002). Unilateral histamine thresholds as available from AAR and PAR (at a flow of 250 cm3/sec) did not differ significantly (p = 0.299). For AAR and APR, histamine thresholds were assessed at 5 different pressure values as well as at 5 different flow values. The thresholds did not appear to be significantly different at any one of those pressure gradients (p = 0.690) or flow values (p = 0.357).
authors.affiliation: VUB, Brussel, België.
authors.forename: F
authors.initials: F
authors.lastname: Gordts
authors.forename: P A
authors.initials: PA
authors.lastname: Clement
authors.forename: M P
authors.initials: MP
authors.lastname: Derde
mesh_terms: D000328:Adult; D000403:Airway Resistance; D005260:Female; D006632:Histamine; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods; D009299:Nasal Provocation Tests / Q000379:methods*; D011312:Pressure
chemical_list: D006632:Histamine
vernacular_title: Neusprovocatie met histamine. Een vergelijking van de drempelbepaling aan de hand van drie rhinomanometrie-methoden.