Effect of maternal ketorolac administration of platelet function in the newborn.
Ketorolac is a potent analgesic agent with antiplatelet properties which is known to cross the placenta. The aim of this study was to determine whether maternal administration of ketorolac in labour had any effect on neonatal platelet function as compared with maternal administration of pethidine and prochlorperazine. Eighteen parous women were studied in labour, twelve received pethidine (control) and six received ketorolac for analgesia. Immediately after delivery, blood was taken from the umbilical vein and anticoagulated with citrate. Platelet aggregation in whole blood was studied. Ketorolac significantly inhibited aggregation in response to arachidonic acid and collagen but not ADP. These findings confirm that ketorolac crosses the placenta. The antiplatelet effects are likely to be related to ketorolac's inhibitory effect on TxA2 production which is required for arachidonic acid and collagen-induced aggregation, but not the primary aggregation response induced by ADP. These effects suggest that ketorolac should be used with caution in patients whose neonates are at risk of haemostatic problems.
Greer
I A
IA
Department of Obstetrics, University of Edinburgh, U.K.
Johnston
J
J
Tulloch
I
I
Walker
J J
JJ
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D005260:Female; D005333:Fetus; D006801:Humans; D007231:Infant, Newborn; D020910:Ketorolac; D008431:Maternal-Fetal Exchange; D008614:Meperidine / Q000494:pharmacology; D007744:Obstetric Labor Complications / Q000188:drug therapy*; D010974:Platelet Aggregation / Q000187:drug effects*; D011247:Pregnancy; D011758:Pyrroles / Q000494:pharmacology*; D011897:Random Allocation; D014046:Tolmetin / Q000031:analogs & derivatives / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011758:Pyrroles; D008614:Meperidine; D014046:Tolmetin; D020910:Ketorolac