Nodular sclerosing Hodgkin's disease with giant Reed-Sternberg cells.
A 70-year-old woman with multiple symptoms and extensive lymphadenopathy had a lymph node biopsy specimen that contained highly pleomorphic, giant Reed-Sternberg cells that resembled cells from other malignant giant cell neoplasms. The cells were strongly positive for Leu-M1, alpha 1-antitrypsin, S-100 protein, kappa light chain, and lambda light chain. With five courses of chemotherapy for pathologic stage IV-B Hodgkin's disease, the patient achieved a complete remission, and remains free of disease 85 months after diagnosis.
Frierson
H F
HF
Department of Pathology, University of Virginia Medical Center, Charlottesville 22908.
Innes
D J
DJ
Hess
C E
CE
D000368:Aged; D001706:Biopsy; D001856:Bone Marrow Examination; D001859:Bone Neoplasms / Q000188:drug therapy / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005870:Giant Cell Tumors / Q000473:pathology; D006644:Histiocytes / Q000473:pathology*; D006689:Hodgkin Disease / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D012598:Sclerosis