Evaluation of methods of administering tyramine to raise systolic blood pressure.
To compare the relative merits of two different administration regimens, tyramine was administered intravenously in ascending doses to 12 healthy subjects to raise systolic blood pressure slightly more than 30 mm Hg. Six subjects received tyramine by bolus injection and six other subjects received tyramine by infusion. The bolus dose of tyramine needed was 4.34 +/- 1.51 mg (X +/- SD) and the infusion rate needed was 1.11 +/- 0.33 mg/min. Four blood pressure response patterns to continuous tyramine infusion were observed. Because different units were measured for the quantity of tyramine administered, the between-subject variance estimate to within-subject variance estimate ratios were calculated. The two techniques had equivalent consistency. With the bolus method, in contrast to the infusion procedure, the dose-response relationship was obvious in most subjects. Therefore the bolus method was judged to be more useful than the infusion method.
Pace
D G
DG
Department of Clinical Research and Development, Hoffmann-La Roche, Inc., Nutley, NJ 07110.
Reele
S B
SB
Rozik
L M
LM
Rogers-Phillips
C A
CA
Dabice
J A
JA
Givens
S V
SV
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D011897:Random Allocation; D012044:Regression Analysis; D014439:Tyramine / Q000008:administration & dosage*
D014439:Tyramine