Effect of a single intravenous dose of verapamil on some immune parameters in duodenal ulcer patients.
The effect of a single intravenous dose of calcium channel blocking agent verapamil (VER) on immune parameters in humans remains uncertain. In this study the effects of VER on lymphocyte subpopulations, interleukin 1 (IL-1) and 2 (IL-2) production in vitro, autologous mixed lymphocyte reaction (AMLR), IL-2 receptor expression (Tac positive cells) and natural killer (NK) cell activity were assessed. The investigations were undertaken on 12 hospitalized men, aged 19-23 years, with small abdominal complaints. None of them had active duodenal ulcer disease, while in the remaining no signs of organic disease were found. VER was given intravenously in a dose of 0.15 mg/kg and examinations were performed on peripheral blood mononuclear cells (PBL) drawn before and 30 and 150 min following VER injection. The single VER dose induced a significant, but transient increase in T, T helper, T suppressor lymphocytes and monocytes, and decrease in IL-1 and IL-2 generation as well as diminished Tac antigen expression. These data provide evidence that calcium channel blockers may transiently disturb immunoregulation.
Malec
P
P
1st Department of Internal Medicine, Military Medical Academy, Lódź, Poland.
Tchórzewski
H
H
Markiewicz
K
K
Zeman
K
K
Baj
Z
Z
Nowak
Z
Z
Pokoca
L
L
D000328:Adult; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007166:Immunosuppressive Agents; D007275:Injections, Intravenous; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008297:Male; D015375:Receptors, Interleukin-2 / Q000187:drug effects; D014700:Verapamil / Q000008:administration & dosage / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D007375:Interleukin-1; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D014700:Verapamil