title: Concentrations of isotretinoin and the arotinoid Ro 15-0778 in plasma and tissues of hamsters and rats.
abstract: The arotinoid Ro 15-0778 is a potent inhibitor of sebum secretion in rodents but not in humans, while isotretinoin (13-cis-retinoic acid, Accutane) inhibits sebum secretion in rodents and humans. The concentrations of Ro 15-0778 and isotretinoin were determined in plasma and target tissues of castrated, testosterone-stimulated hamsters after oral and topical dosing and in castrated, testosterone-stimulated rats after oral dosing. Comparison of this concentration data to that obtained in the plasma and sebum of humans after dosing with Ro 15-0778 and with isotretinoin did not explain why Ro 15-0778 was a potent inhibitor of sebum production in rodents but not in humans.
authors.affiliation: Dermatology Research, Hoffmann-La Roche Inc., Nutley, N.J.
authors.forename: F M
authors.initials: FM
authors.lastname: Vane
authors.forename: S S
authors.initials: SS
authors.lastname: Chari
authors.forename: J F
authors.initials: JF
authors.lastname: Hurley
authors.forename: S S
authors.initials: SS
authors.lastname: Shapiro
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D015474:Isotretinoin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008647:Mesocricetus; D051381:Rats; D011919:Rats, Inbred Strains; D012176:Retinoids / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D012629:Sebum / Q000378:metabolism; D012867:Skin / Q000378:metabolism
chemical_list: D012176:Retinoids; C053595:temarotene; D015474:Isotretinoin