A comparison of blood, crystalloid and oxygenated crystalloid cardioplegia solutions on myoglobin and creatine kinase release following cardiac surgery.
Oxygenated crystalloid cardioplegia was found not to produce better cardioprotection than blood or crystalloid cardioplegia, as assessed by myoglobin and creatine kinase MB (CPK-MB) isoenzyme, in patients undergoing coronary artery surgery. Myoglobin and CPK-MB levels were found to peak at 1 and 3 h, respectively, following release of the aortic cross-clamp. There was a good correlation between peak myoglobin and CPK-MB levels. CPK-MB of non-cardiac origin was found to represent a substantial proportion of total CPK-MB 4 h after the release of the aortic cross-clamp.
Gerrish
S P
SP
Department of Cardiothoracic Surgery, Northern General Hospital, Sheffield, UK.
Goiti
J J
JJ
Hunsley
J E
JE
D001769:Blood; D002314:Cardioplegic Solutions / Q000494:pharmacology*; D001026:Coronary Artery Bypass; D003402:Creatine Kinase / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism*; D009211:Myoglobin / Q000378:metabolism*; D010100:Oxygen / Q000494:pharmacology; D011184:Postoperative Period; D011188:Potassium / Q000494:pharmacology; D017680:Potassium Compounds; D011446:Prospective Studies
D002314:Cardioplegic Solutions; D007527:Isoenzymes; D009211:Myoglobin; D017680:Potassium Compounds; C018369:potassium cardioplegic solution; D003402:Creatine Kinase; D011188:Potassium; D010100:Oxygen