title: Chromosome localization of the human oncogene INT1 to 12q13 by in situ hybridization.
abstract: The human oncogene INT1 has been mapped to chromosome band 12q13 by in situ hybridization. The precise localization of this gene is of particular interest, since the region 12q13----q14 has been reported to be involved in chromosomal rearrangements in lipomas, myxoid liposarcomas, pleomorphic adenomas, and myomas. The involvement of this region in both benign and malignant tumors suggests a common pathogenetic pathway in which changes affecting INT1 may be an important step.
authors.affiliation: Department of Clinical Genetics, University Hospital, Lund, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Arheden
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: B
authors.initials: B
authors.lastname: Strömbeck
authors.forename: M
authors.initials: M
authors.lastname: Isaksson
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12 / Q000648:ultrastructure; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051153:Wnt Proteins; D051155:Wnt1 Protein; D029961:Zebrafish Proteins
chemical_list: D011518:Proto-Oncogene Proteins; C495247:WNT1 protein, human; D051153:Wnt Proteins; D051155:Wnt1 Protein; D029961:Zebrafish Proteins