title: Estimation of extracellular fluid volume from plasma clearance on technetium-99m DTPA by a single-injection, two-sample method.
abstract: A simple method is presented for estimating extracellular fluid volume from the plasma clearance of [99mTc])DTPA or [169Yb]DTPA. Two plasma samples are required, at 1 and 3 hr, following a single intravenous injection. (The same plasma samples can be used for measurement of glomerular filtration rate.) Using the complete plasma clearance curve as a reference (eight samples at 10 to 240 min), the error of the two-sample method in 40 patients was 1.5 I for [99mTc]DTPA, 2.1 I for [169Yb]DTPA (residual standard deviation).
authors.affiliation: Division of Nuclear Medicine, University of Alabama Hospital, Birmingham 35233.
authors.forename: C D
authors.initials: CD
authors.lastname: Russell
authors.forename: P G
authors.initials: PG
authors.lastname: Bischoff
authors.forename: K L
authors.initials: KL
authors.lastname: Rowell
authors.forename: L K
authors.initials: LK
authors.lastname: Lloyd
authors.forename: E V
authors.initials: EV
authors.lastname: Dubovsky
mesh_terms: D005110:Extracellular Space; D006801:Humans; D007677:Kidney Function Tests / Q000379:methods*; D009942:Organometallic Compounds / Q000378:metabolism; D004369:Pentetic Acid / Q000378:metabolism; D013667:Technetium / Q000378:metabolism; D016284:Technetium Tc 99m Pentetate
chemical_list: D009942:Organometallic Compounds; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate