title: [In vitro sensitivity of Aspergillus to terbinafine: comparative study on amphotericin B, 5-fluorocytosine and ketoconazole].
abstract: Terbinafine, a new antifungal agent derived from allylamine, effective by oral route, was tested against 32 different strains of Aspergilli to determine its in vitro efficiency compared with amphotericin B, 5-fluorocytosine and ketoconazole. Antifungal sensitivity was determine by the MIC method in liquid and solid mediums (Sabouraud, Casitone, YMA, YMB, YNB): with MIC between 0.005 and 5 micrograms/ml, whatever the species and the techniques, terbinafine is more efficient than amphotericin B, ketoconazole (0.5 to 100 micrograms/ml) and 5-FC (1-greater than 100 micrograms/ml).
authors.affiliation: Laboratoire de Botanique et Cryptogamie, Faculté de Pharmacie, Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Goudard
authors.forename: P
authors.initials: P
authors.lastname: Regli
authors.forename: Y
authors.initials: Y
authors.lastname: Buffard
authors.forename: B
authors.initials: B
authors.lastname: Gabriel
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects*; D005437:Flucytosine / Q000494:pharmacology*; D007654:Ketoconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000494:pharmacology*; D000077291:Terbinafine
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000666:Amphotericin B; D005437:Flucytosine; D000077291:Terbinafine; D007654:Ketoconazole
vernacular_title: Sensibilité in vitro des Aspergillus à la terbinafine: étude comparative avec l'amphotéricine B, la 5-fluorocytosine et le kétoconazole.