Renal dysfunction following high-dose carboplatin treatment.
A case history is reported or renal failure during and after treatment with carboplatin for 3 days, total dose 750 mg/m2, in a conditioning regimen prior to autologous bone marrow transplantation. Pretreatment renal function was compromised after nephrectomy and chemotherapy with cisplatin. A decrease in glomerular filtration rate concurred with a decrease in excretion of platinum in the urine and an increase in urinary beta 2 microglobulin. Treatment with high-dose carboplatin in patients with impaired renal function and previous treatment with cisplatin may lead to further loss of renal function.
Mulder
P O
PO
Department of Intensive care Medicine, University Hospital, Groningen, The Netherlands.
Sleijfer
D T
DT
de Vries
E G
EG
Uges
D R
DR
Mulder
N H
NH
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016026:Bone Marrow Transplantation; D016190:Carboplatin; D003404:Creatinine / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009944:Organoplatinum Compounds / Q000009:adverse effects*
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D003404:Creatinine; D016190:Carboplatin