Regulation of H-2 class I gene expression in virally transformed and infected cells.
Early studies of the resistance and susceptibility of mouse strains to radiation-induced leukemia virus have demonstrated the important role of altered histocompatibility (H-2) antigen expression in the effectiveness of the immune response of the host to virus-infected and transformed cells. Changes in H-2 gene expression have now been correlated with disease resistance in a variety of viral systems. The experiments discussed indicate that viruses may directly or indirectly affect H-2 antigen expression at various levels of gene expression. These investigations generate a framework for approaching a molecular understanding of viral-induced changes in H-2 gene expression.
Brown
G D
GD
Department of Pathology, New York University Medical Center, New York.
Choi
Y
Y
Pampeno
C
C
Meruelo
D
D
D000818:Animals; D002472:Cell Transformation, Viral; D005786:Gene Expression Regulation; D005805:Genes, MHC Class I; D006183:H-2 Antigens / Q000235:genetics*; D007942:Leukemia, Experimental / Q000235:genetics / Q000276:immunology; D051379:Mice; D012190:Retroviridae / Q000235:genetics; D014412:Tumor Virus Infections / Q000235:genetics / Q000276:immunology
D006183:H-2 Antigens