title: Cure of brain abscess caused by Nocardia asteroides resistant to multiple antibiotics.
abstract: A 29-year-old man with pulmonary infiltrates due to pulmonary alveolar proteinosis had Nocardia asteroides pneumonia and brain abscess. The nocardial infections persisted after therapy with sulfonamides, minocycline, and cefotaxime. Based on the susceptibility studies and serum antibiotic concentrations, he was treated with minocycline, 400 to 600 mg daily, cefotaxime, 12 to 30 gm daily, and probenecid for 15 months. Proteinuria observed near the completion of therapy was transient. Three years after therapy, the infections appear to have been cured.
authors.affiliation: Department of Internal Medicine, University of Kansas Medical Center, College of Health Sciences and Hospital, Kansas City 66103.
authors.forename: J
authors.initials: J
authors.lastname: Fried
authors.forename: D
authors.initials: D
authors.lastname: Hinthorn
authors.forename: J
authors.initials: J
authors.lastname: Ralstin
authors.forename: P
authors.initials: P
authors.lastname: Gerjarusak
authors.forename: C
authors.initials: C
authors.lastname: Liu
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001922:Brain Abscess / Q000150:complications / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications; D008297:Male; D008826:Microbial Sensitivity Tests; D009617:Nocardia Infections / Q000150:complications / Q000188:drug therapy*; D009616:Nocardia asteroides / Q000187:drug effects / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents