[Value of immunological analysis for the detection of residual neuroblasts in the bone marrow].
Immunological analysis is complementary of morphological analyses in the detection of neuroblastoma BM metastases. It attests the neuroblastic nature of rare pseudolymphocytic isolated cells. The combination of immunocytochemical technique (alkaline phosphate) and double-immunofluorescence technique allows the detection of as few as 10(-5) residual neuroblastoma cells. At the time of bone marrow harvest, it permits a precise evaluation of malignant cells in the graft.
Combaret
V
V
Centre Léon-Bérard, Lyon, France.
Favrot
M C
MC
Bailly
C
C
Philip
I
I
Zucker
J M
JM
Philip
T
T
D001853:Bone Marrow / Q000473:pathology; D001856:Bone Marrow Examination; D016026:Bone Marrow Transplantation; D001859:Bone Neoplasms / Q000556:secondary; D006801:Humans; D007158:Immunologic Techniques; D007694:Killer Cells, Natural; D009447:Neuroblastoma / Q000473:pathology*
Intérêt de l'analyse immunologique pour la détection de neuroblastes résiduels dans la moelle osseuse.