[Synthesis and pharmacologic activity of 9-R-octahydroindolo[2,3-a]quinolazine].
By acid induced cyclization of quinolizidin-1-one 4-R-phenylhydrazones several derivatives of 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine (1), bearing a substituent on position 9, were prepared. When R = Cl this reaction gave rise also to a red-orange compound to which the structure (V) of 1-(p-chloro)phenylazo-3,4,6,7,8,9-hexahydroquinolizine was assigned. Substances (1 b)-(1-f) were tested for spontaneous locomotor, muscle relaxant, analgesic, antiinflammatory, diuretic and cardiovascular activities and for influence on pentylentetrazole and sodium pentobarbital actions. Interesting levels of activity were exhibited in several cases.
Boido-Canu
C
C
Istituto di Scienze Farmaceutiche, Università di Genova.
Boido
V
V
Sparatore
F
F
Sparatore
A
A
Susanna
V
V
Russo
S
S
Cenicola
M L
ML
Marmo
E
E
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D004232:Diuretics / Q000138:chemical synthesis; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis; D010424:Pentobarbital / Q000037:antagonists & inhibitors; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011807:Quinolizines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004232:Diuretics; D007211:Indoles; D009125:Muscle Relaxants, Central; D011807:Quinolizines; D010424:Pentobarbital; D010433:Pentylenetetrazole
Sintesi ed attività farmacologica di 9-R-ottaidroindolo [2,3-a]chinolizine.