The effect of aminopyridines on the activity recorded in the dorsal roots of an isolated hamster spinal cord preparation.
1. The aminopyridines (AP) increase the activity recorded on the dorsal roots of an isolated hamster spinal cord preparation. 2. The threshold for 4-AP was 4 X 10(-6) M and the maximum effect was 3 X 10(-5) M. The threshold for 2AP and 3AP was 3 X 10(-5) M and the maximum effect was at 10(-3) M. 3. It took longer for the preparation to recover on washing from treatment with 4-AP than from 2-AP or 3-AP. Washing often showed a transient increase in activity. 4. Treatment with AP changed the pattern of firing so that the activity after treatment and prolonged washing showed a bursting pattern. 5. The activity recorded in the dorsal roots is generated within the spinal cord and may be related to activity of central pattern generators.
Al-Zamil
Z M
ZM
Department of Neurophysiology, Medical School, Southampton University, U.K.
Bagust
J
J
Kerkut
G A
GA
D000200:Action Potentials / Q000187:drug effects; D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D004566:Electrodes; D005727:Ganglia, Spinal / Q000187:drug effects*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008647:Mesocricetus; D009475:Neurons, Afferent / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects*
D000631:Aminopyridines