title: A comparison of autoantibodies and common DNA antibody idiotypes in SLE patients and their spouses.
abstract: In order to determine whether environmental influence per se might influence autoantibody production, sera from the spouses of 20 SLE patients were examined. No antibodies to cardiolipin, poly (ADP-ribose), or ENA were detected and none had detectable rheumatoid factor. One weakly positive ANA reaction was noted, one had anti-DNA antibodies (by RIA and ELISA) and in two sera the common DNA antibody idiotype 16/6 was found. The idiotype was not, however, present on either anti-DNA or anti-K30 antibodies. Although long-term analyses are required, it is evident that sharing the same environment with patients who commonly express a wide range of autoantibodies and common idiotypes rarely leads to their expression in non-autoimmune subjects.
authors.affiliation: Immunology Department, St. Thomas' Hospital, London.
authors.forename: D A
authors.initials: DA
authors.lastname: Isenberg
authors.forename: W
authors.initials: W
authors.lastname: Williams
authors.forename: S
authors.initials: S
authors.lastname: Le Page
authors.forename: G
authors.initials: G
authors.lastname: Swana
authors.forename: R
authors.initials: R
authors.lastname: Feldman
authors.forename: I
authors.initials: I
authors.lastname: Addison
authors.forename: R
authors.initials: R
authors.lastname: Bakimer
authors.forename: Y
authors.initials: Y
authors.lastname: Shoenfeld
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D002308:Cardiolipins / Q000032:analysis; D004247:DNA / Q000276:immunology*; D005260:Female; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000032:analysis*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008393:Marriage; D011064:Poly Adenosine Diphosphate Ribose / Q000276:immunology; D012217:Rheumatoid Factor / Q000032:analysis
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D002308:Cardiolipins; D007130:Immunoglobulin Idiotypes; D011064:Poly Adenosine Diphosphate Ribose; D004247:DNA; D012217:Rheumatoid Factor