Genetic polymorphism of IgG in mink. II. A genetic analysis of allotypes.
Population distribution and inheritance pattern were analyzed in mink IgG allotypes: L1 (L chains), H2, H3, H4, H6, H7, and H8 (the constant region of the H chains, i.e. C gamma-allotypes) and conformational allotype 5 with unknown chain localization. Contrary to expectation, neither allelism, nor close linkage were demonstrated for these allotypes. The major feature of the inheritance of H2, H3, and H4 C gamma-allotypes, as well as allotype 5, was significant excess of negative (without these allotypes) progeny in the F1 generation from monohybrid cross. The explanation offered for this departure of the C gamma-allotypes from normal Mendelian genetics suggests widespread latencies of their expression in mink.
Belyaev
D K
DK
Institute of Cytology and Genetics, USSR Academy of Sciences.
Fomicheva
I I
II
Taranin
A V
AV
Baranov
O K
OK
D000818:Animals; D003433:Crosses, Genetic; D005787:Gene Frequency; D005803:Genes, Immunoglobulin; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007128:Immunoglobulin Fragments / Q000235:genetics; D007074:Immunoglobulin G / Q000235:genetics*; D008907:Mink / Q000235:genetics* / Q000276:immunology; D010641:Phenotype; D011110:Polymorphism, Genetic
D007126:Immunoglobulin Allotypes; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G