title: [Changes in the cell surface and cytoskeleton of A-431 cells under the action of epidermal growth factor].
abstract: Certain changes in human carcinoma A-431 are found by scanning electron microscopy. The early cell response to growth factor (after 10 minutes) involves a disappearance of microvilli, an appearance of ruffles and rounded cells, along with a decrease in cell attachment to the substrate. The cell surface changes correlate with the state of cytoskeleton elements: the material stained with iron hematoxylin is accumulated in ruffle formation sites. Retractional fibrils filled with the cytoskeleton material result from a decrease in the cell area.
authors.forename: V I
authors.initials: VI
authors.lastname: Skopicheva
authors.forename: V G
authors.initials: VG
authors.lastname: Skopichev
authors.forename: L V
authors.initials: LV
authors.lastname: Teslenko
authors.forename: N N
authors.initials: NN
authors.lastname: Nikol'skiĭ
mesh_terms: D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D003599:Cytoskeleton / Q000187:drug effects* / Q000648:ultrastructure; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008871:Microvilli / Q000187:drug effects / Q000648:ultrastructure; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000648:ultrastructure
chemical_list: D004815:Epidermal Growth Factor
vernacular_title: Izmeneniia kletochnoĭ poverkhnosti i tsitoskeleta kletok A-431 pri deĭstvii épidermal'nogo faktora rosta.