Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia.
12 AIDS/ARC patients with or suspected of Pneumocystis carinii pneumonia were treated with co-trimoxazole and received supplementary folic or folinic acid to avoid peripheral blood cytopenia. Most patients developed decreased numbers of neutrophils and hemoglobin while receiving co-trimoxazole. Supplementary folate/folinate could not abolish the drug-induced cytopenia. Routine prescription of folinic acid is not recommended. Folic acid is cheap and may be beneficial and should be prescribed.
Bygbjerg
I C
IC
Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Lund
J T
JT
Hørding
M
M
D000386:AIDS-Related Complex / Q000150:complications; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000740:Anemia / Q000139:chemically induced / Q000517:prevention & control; D004338:Drug Combinations / Q000009:adverse effects / Q000627:therapeutic use; D005492:Folic Acid / Q000627:therapeutic use*; D006402:Hematologic Diseases / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D007970:Leukopenia / Q000139:chemically induced / Q000517:prevention & control; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy*; D011446:Prospective Studies; D013420:Sulfamethoxazole / Q000009:adverse effects* / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000139:chemically induced / Q000517:prevention & control; D013997:Time Factors; D014295:Trimethoprim / Q000009:adverse effects* / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D005492:Folic Acid; D014295:Trimethoprim; D013420:Sulfamethoxazole; D002955:Leucovorin