Effect of calcium-channel blockade on the aldosterone response to sodium depletion and potassium loading in man.
Angiotensin II (Ang II) and potassium (K+) increase aldosterone (Aldo) production in vitro via Ca2+-dependent mechanisms. To determine the effects of Ca2+ antagonism in vivo, we examined the influence of nifedipine on the Aldo response to Na+ depletion and K+ loading in 11 healthy subjects. On the fifth day of a low-Na+/high-K+ diet (10 mmol Na+/100 mmol K+) the subjects were randomly given either nifedipine 30 mg po or placebo, and on the sixth day they received the alternative drug. KCl in 5% glucose was infused on days 5 and 6 from 10:00 to 12:00 AM (0.6 mmol/kg over 2 hours). Dexamethasone was given to suppress adrenal corticotrophic hormone. Plasma renin activity (PRA) and plasma Aldo were determined every 20 minutes. Nifedipine induced a rise in heart rate at 60 minutes but did not change blood pressure. During KCl/glucose infusions, plasma glucose increased significantly, but plasma K+ remained stable. PRA, but not baseline plasma Aldo, was stimulated by nifedipine. KCl provoked a significant and similar Aldo rise (P less than .01) under placebo and nifedipine. Baseline Aldo/PRA ratio was reduced under nifedipine when compared to placebo (P less than .01), whereas during KCl infusions this ratio was similarly elevated under placebo and nifedipine. We conclude that acute inhibition of slow Ca2+ channels does not interfere with K+-induced Aldo secretion in man, suggesting that adaptive mechanisms operate in vivo.
Favre
L
L
Division of Endocrinology, University Hospital, Geneva, Switzerland.
Riondel
A
A
Vallotton
M B
MB
D000328:Adult; D000450:Aldosterone / Q000096:biosynthesis* / Q000652:urine; D001794:Blood Pressure / Q000187:drug effects; D004039:Diet, Sodium-Restricted; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D011188:Potassium / Q000097:blood / Q000652:urine; D011189:Potassium Chloride / Q000008:administration & dosage*; D012083:Renin / Q000097:blood; D012964:Sodium / Q000652:urine
D000450:Aldosterone; D011189:Potassium Chloride; D012964:Sodium; D012083:Renin; D009543:Nifedipine; D011188:Potassium