Furosemide-induced glucose intolerance in mice is associated with reduced insulin secretion.
The effect of furosemide on carbohydrate metabolism was studied in ob/ob mice. Intraperitoneal injection of a single dose of furosemide (200 mg/kg body weight) into fasted mice resulted in acute hyperglycaemia and two days after such a single dose, the mice showed fasting hyperglycaemia and glucose intolerance. Pancreatic islets from mice that had been injected with furosemide (200 mg/kg body weight) two days prior to the in vitro experiments showed increased basal (3 mmol/1 D-glucose) and decreased glucose-stimulated (20 mmol/1) insulin release. Islets from furosemide- or saline-injected animals showed no difference in islet insulin content. The results show that furosemide has both acute and long-term effects on carbohydrate metabolism in ob/ob mice. It is suggested that this, at least in part, is due to an effect on the pancreatic beta-cells.
Sandström
P E
PE
Department of Histology and Cell Biology, University of Umeå, Sweden.
Sehlin
J
J
D000818:Animals; D001786:Blood Glucose; D005260:Female; D005665:Furosemide / Q000009:adverse effects*; D006943:Hyperglycemia / Q000139:chemically induced*; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D051379:Mice
D001786:Blood Glucose; D007328:Insulin; D005665:Furosemide