title: Corporate influence on threshold limit values.
abstract: Investigations into the historical development of specific Threshold Limit Values (TLVs) for many substances have revealed serious shortcomings in the process followed by the American Conference of Governmental Industrial Hygienists. Unpublished corporate communications were important in developing TLVs for 104 substances; for 15 of these, the TLV documentation was based solely on such information. Efforts to obtain written copies of this unpublished material were mostly unsuccessful. Case studies on the TLV Committee's handling of lead and seven carcinogens illustrate various aspects of corporate influence and interaction with the committee. Corporate representatives listed officially as "consultants" since 1970 were given primary responsibility for developing TLVs on proprietary chemicals of the companies that employed them (Dow, DuPont). It is concluded that an ongoing international effort is needed to develop scientifically based guidelines to replace the TLVs in a climate of openness and without manipulation by vested interests.
authors.forename: B I
authors.initials: BI
authors.lastname: Castleman
authors.forename: G E
authors.initials: GE
authors.lastname: Ziem
mesh_terms: D000181:Acrylonitrile; D001151:Arsenic; D001194:Asbestos; D001388:Aziridines; D001554:Benzene; D002273:Carcinogens; D004282:Documentation; D004781:Environmental Exposure; D049673:History, 20th Century; D006801:Humans; D007221:Industry / Q000592:standards*; D007391:International Cooperation; D007854:Lead; D008452:Maximum Allowable Concentration; D009153:Mutagens; D009784:Occupational Diseases / Q000517:prevention & control*; D013463:Sulfuric Acid Esters; D014752:Vinyl Chloride
chemical_list: D001388:Aziridines; D002273:Carcinogens; D009153:Mutagens; D013463:Sulfuric Acid Esters; D001194:Asbestos; D007854:Lead; C033132:aziridine; D001554:Benzene; C007482:dimethyl sulfate; D000181:Acrylonitrile; D001151:Arsenic; D014752:Vinyl Chloride