title: [Multiple primary intraductal tumors of Wirsung's duct: demonstration of a relation between benign and malignant tumors].
abstract: A case of multiple villous and, more rarely, tubulovillous adenomas of the main pancreatic duct, associated with a diffuse infiltrating adenocarcinoma of the pancreas in which evidence for a link between these lesions is supported by histopathologic features, is reported in a 53 year old patient. Clinical presentation included abdominal pain, weight loss and chronic diarrhea with steatorrhea related to pancreatic insufficiency. Retrograde endoscopic pancreatography showed a complete stenosis of the main pancreatic duct located 3 mm beyond the ampulla of Vater. CT scan showed an heterogeneous cephalic pancreatic tumor with extensive enlargement of the main pancreatic duct. After total pancreatectomy, recovery was maintained (follow-up 18 months). By analogy to colorectal tumors, a new pathologic classification of these rare neoplasms may be proposed.
authors.affiliation: Service de Gastroentérologie, Hôpital Saint-Lazare, Paris.
authors.forename: M
authors.initials: M
authors.lastname: Halphen
authors.forename: C
authors.initials: C
authors.lastname: Hoang
authors.forename: P
authors.initials: P
authors.lastname: Hautefeuille
authors.forename: P
authors.initials: P
authors.lastname: Marteau
authors.forename: A
authors.initials: A
authors.lastname: Bitoun
authors.forename: P
authors.initials: P
authors.lastname: Jacquenod
authors.forename: A
authors.initials: A
authors.lastname: Caruana
authors.forename: B
authors.initials: B
authors.lastname: Cochand-Priollet
authors.forename: A
authors.initials: A
authors.lastname: Galian
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000236:Adenoma / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010183:Pancreatic Ducts; D010190:Pancreatic Neoplasms / Q000473:pathology*
vernacular_title: Tumeurs intra-canalaires primitives multiples du canal de Wirsung: démonstration d'une filiation entre tumeurs bénignes et malignes.