title: Premenstrual changes. Impaired hormonal homeostasis.
abstract: Premenstrual changes (PMCs) in mood and behavior are very prevalent. Nonetheless, their pathophysiology is still obscure and no proven treatment is yet available. Evaluation of the plethora of available data leads to the suggestion that PMCs may result from a temporary impairment of homeostasis among a multitude of systems. This impairment is triggered by a differential pace and magnitude of change-over-time in levels of several hormones and other substances during the luteal phase.
authors.affiliation: State University of New York, Buffalo.
authors.forename: U
authors.initials: U
authors.lastname: Halbreich
authors.forename: I H
authors.initials: IH
authors.lastname: Alt
authors.forename: L
authors.initials: L
authors.lastname: Paul
mesh_terms: D004723:Endorphins / Q000097:blood; D005260:Female; D006706:Homeostasis; D006728:Hormones / Q000097:blood*; D006801:Humans; D008597:Menstrual Cycle; D009490:Neurosecretory Systems / Q000378:metabolism* / Q000503:physiopathology; D011293:Premenstrual Syndrome / Q000097:blood* / Q000503:physiopathology; D011388:Prolactin / Q000097:blood; D011453:Prostaglandins / Q000097:blood; D013997:Time Factors; D014667:Vasopressins / Q000097:blood
chemical_list: D004723:Endorphins; D006728:Hormones; D011453:Prostaglandins; D014667:Vasopressins; D011388:Prolactin