Mutagenic activity of promutagens in plants: indirect evidence of their activation.
This review summarizes data concerning mutagenic activity of promutagens in various plant in vivo assays. These data are compared with the present knowledge about the metabolism of xenobiotics and activation of promutagens in plants obtained by biochemical studies and by the separation of the activation process from the genetic endpoints assayed for the mutagenicity. The article documents a differential response of plant species in the endogenous transforming of various classes of promutagens into mutagens. Attention is devoted to the following types of promutagens: nitrosamines, polycyclic aromatic hydrocarbons and aromatic amines, aflatoxins, pyrrolizidine alkaloids, diallate, styrene, vinylchloride, ethanol, cycasin, nitrofurans, sodium azide, s-triazine herbicides, 1,2-dibromoethane and maleic hydrazide.
Velemínský
J
J
Institute of Experimental Botany, Czechoslovak Academy of Sciences, Prague.
Gichner
T
T
D000348:Aflatoxins / Q000378:metabolism; D000588:Amines / Q000378:metabolism; D000818:Animals; D001711:Biotransformation; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000096:biosynthesis* / Q000145:classification / Q000494:pharmacology; D009602:Nitrosamines / Q000378:metabolism; D010084:Oxidation-Reduction; D010575:Pesticides / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism; D010944:Plants / Q000187:drug effects / Q000378:metabolism*; D011083:Polycyclic Compounds / Q000378:metabolism; D013045:Species Specificity
D000348:Aflatoxins; D000588:Amines; D009153:Mutagens; D009602:Nitrosamines; D010575:Pesticides; D010940:Plant Proteins; D011083:Polycyclic Compounds; D006899:Mixed Function Oxygenases