title: [Detection of left ventricular thrombi after acute myocardial infarction using Ga-67-DFO-DAS-fibrinogen].
abstract: Ga-67-DFO-DAS-fibrinogen (Ga-fbg) scintigraphy, a new radiopharmaceutical method, was performed for detecting intraventricular thrombi following acute myocardial infarction in five patients. The thrombi in four of them were detected by two-dimensional echocardiography (2DE) and that in the fifth patient was suspected during magnetic resonance imaging. Imaging of the heart was performed using a scinticamera with a medium energy collimator and multiple views (anterior, LAO 30 degrees, LAO 45 degrees, and lateral) three and four days after the intravenous administration of Ga-fbg. By Ga-fbg scintigraphy, intraventricular thrombi were detected in four patients. The size of the thrombi visualized by Ga-fbg appeared larger than those by 2DE. In one patient examined again after anticoagulant therapy, a thrombus was missed by 2-DE, but it was detected by Ga-fbg, though the radioactivity of the thrombus decreased. We concluded that Ga-fbg scintigraphy is a very simple method and sufficiently useful for detecting active left ventricular thrombi and for monitoring the effect of anticoagulant therapy. It could be more sensitive than 2DE for determining the extent of an active intraventricular thrombus.
authors.affiliation: First Department of Internal Medicine, Osaka City University Medical School.
authors.forename: H
authors.initials: H
authors.lastname: Itagane
authors.forename: K
authors.initials: K
authors.lastname: Hirota
authors.forename: M
authors.initials: M
authors.lastname: Teragaki
authors.forename: K
authors.initials: K
authors.lastname: Akioka
authors.forename: M
authors.initials: M
authors.lastname: Yasuda
authors.forename: H
authors.initials: H
authors.lastname: Oku
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: H
authors.initials: H
authors.lastname: Ochi
mesh_terms: D000328:Adult; D003676:Deferoxamine; D004452:Echocardiography; D005260:Female; D005340:Fibrinogen; D005710:Gallium Radioisotopes; D006331:Heart Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000209:etiology; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D011877:Radionuclide Imaging; D013213:Starch / Q000031:analogs & derivatives*; D013927:Thrombosis / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000209:etiology
chemical_list: D005710:Gallium Radioisotopes; C056464:gallium(67)-deferoxamine-dialdehyde starch-fibrinogen conjugate; D005340:Fibrinogen; D013213:Starch; D003676:Deferoxamine