title: Budesonide nasal spray as prophylactic treatment after polypectomy (a double blind clinical trial).
abstract: This double-blind parallel-group study compared the effect of budesonide with placebo, in the prophylaxis of nasal polyp recurrence after evulsion. Seventy-three patients with first time or recurrent polypectomy were enrolled. At revisits 3 and 6 months after evulsion, the budesonide-treated patients had significantly lower polyp scores than the placebo-treated patients. Only patients with recurrent nasal polyposis benefited from the budesonide treatment, whereas no effect was evident in patients with first time evulsion.
authors.affiliation: ENT-Clinic, Falu hospital, Falun, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Hartwig
authors.forename: M
authors.initials: M
authors.lastname: Lindén
authors.forename: C
authors.initials: C
authors.lastname: Laurent
authors.forename: A K
authors.initials: AK
authors.lastname: Vargö
authors.forename: N
authors.initials: N
authors.lastname: Lindqvist
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D019819:Budesonide; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000517:prevention & control* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D011282:Pregnenediones / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D011282:Pregnenediones; D019819:Budesonide