Pharmacologic effects of lactones isolated from Pulsatilla alpina subsp. apiifolia.
Two lactone compounds, protoanemonin and anemonin, were determined in the flowering aerial parts of P. alpina subsp. apiifolia. Anemonin is the primary compound responsible for the antipyretic activity and both anemonin and protoanemonin participate in the sedating effect.
Martin
M L
ML
Department of Physiology and Pharmacology, Faculty of Pharmacy, University of Salamanca, Spain.
Ortíz de Urbina
A V
AV
Montero
M J
MJ
Carrón
R
R
San Román
L
L
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002845:Chromatography / Q000379:methods; D005260:Female; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology*; D006993:Hypnotics and Sedatives; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010936:Plant Extracts / Q000032:analysis; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013030:Spain; D013053:Spectrophotometry / Q000379:methods; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005663:Furans; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D013729:Terpenes; C037354:protoanemonin; C028304:anemonin