title: A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides.
abstract: Depletion of a subset of 70K stress proteins in yeast mutants shows that they are involved in the post-translational import of precursor polypeptides into both mitochondria and the lumen of the endoplasmic reticulum. The identification of such a basic function may explain the remarkable evolutionary conservation of the gene family encoding these proteins.
authors.affiliation: Department of Biochemistry, University of California, Berkeley 94720.
authors.forename: R J
authors.initials: RJ
authors.lastname: Deshaies
authors.forename: B D
authors.initials: BD
authors.lastname: Koch
authors.forename: M
authors.initials: M
authors.lastname: Werner-Washburne
authors.forename: E A
authors.initials: EA
authors.lastname: Craig
authors.forename: R
authors.initials: R
authors.lastname: Schekman
mesh_terms: D005075:Biological Evolution; D001693:Biological Transport, Active; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000235:genetics / Q000502:physiology*; D000072235:Mating Factor; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D009693:Nucleic Acid Hybridization; D010455:Peptides / Q000235:genetics / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D006360:Heat-Shock Proteins; D010455:Peptides; D011498:Protein Precursors; D011506:Proteins; D000072235:Mating Factor