title: Effects of chronic endotoxaemia on oxygen consumption at different ambient temperatures in the unanaesthetised rat.
abstract: Oxygen consumption has been measured at different ambient temperatures at intervals during the intravenous infusion of endotoxin (1 mg/kg.day-1) from a subcutaneously implanted osmotic minipump in unanaesthetised rats. On day 1 of the infusion oxygen consumption was elevated at ambient temperatures of 10, 28, and 31 degrees C but not at 20 degrees C, compared with pair-fed saline-infused controls. There was a significant negative correlation between oxygen consumption on days 1 and 3 and environmental temperature (10, 20, and 28 degrees C) in both groups, but the regression line describing the relation in endotoxin-infused rats was displaced above that for the saline-infused control without a change in slope. The "minimal observed" oxygen consumption, which is taken as an estimate of basal metabolic rate, was elevated by the infusion of endotoxin. The endotoxin-induced increase in "minimal observed" oxygen consumption was removed by indomethacin (5 mg/kg.sc) on day 1 of the infusion but was ineffective on days 3 and 7.
authors.affiliation: North Western Injury Research Centre, University of Manchester, UK.
authors.forename: M I
authors.initials: MI
authors.lastname: Goran
authors.forename: R A
authors.initials: RA
authors.lastname: Little
authors.forename: K N
authors.initials: KN
authors.lastname: Frayn
authors.forename: R
authors.initials: R
authors.lastname: Jones
authors.forename: G
authors.initials: G
authors.lastname: Fozzard
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D001835:Body Weight; D002908:Chronic Disease; D003243:Consciousness; D004195:Disease Models, Animal; D004435:Eating; D004731:Endotoxins; D004926:Escherichia coli; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D013696:Temperature
chemical_list: D004731:Endotoxins; D007213:Indomethacin