[Analysis of the effects of oxytocin, vasopressin, angiotensin, serotonin and histamine on the blood flow in the reproductive organs of swine the during estrous cycle].
We have measured the magnitude of flow in the uterine artery (ua) and in ovarian artery (oa) in the isolated reproductive organs of pig (100-130 kg/per head) perfused with their own blood or Krebs-Henseleit's solution. The pressure was kept on the constant level 100 mm Hg. Were administered intraarterially Oxytocin (O), vasopressin (W), histamine (H), serotonin (5-HT) and hypertensin (A). Their possible influence on the processes of regulation of blood flow in the porcine reproductive organs during oestrus cycle was analysed. It was stated that O produced a decrease of blood flow (bf) in the periovulatory period (1-2 and 16-18 day of cycle). On the other hand doses many times bigger did not cause significant changes in ua in the luteal phase and in oa in all phases of the cycle. Action of O is connected with its pressing action on the uterine vessels, contracted by the smooth muscular coat of this organ. Limiting bf action of W and A is mainly connected with their direct vasoconstructive effect. Our results indicated that in physiological conditions during oestrous cycle O, W and A did not evoke significant changes in the regulation of blood flow in the porcine reproductive organs. High sensitivity of the investigated vessels on 5-HT in the luteal phase and lower sensitivity in the periovulatory phase could indicate serotonin's influence on the regulating changes of blood flow during oestrous cycle. Vessels of both investigated areas were very sensitive to H. Especially high sensitivity of oa vessels on H is correlated with an increase of sensitivity of the vessels on 5-HT and catecholamines in the luteal phase. It seem that H has significant importance as a factor antagonising influence of 5-HT and catecholamines in the luteal phase of cycle in the pig. Sensitivity of oa vessels on the investigated drugs was lower in all phases of the cycle studied than sensitivity of ua vessels, the only exception was when H was used. We observed similar reaction on used drugs, both in experiments with perfusion with the blood and with the Krebs-Henseleit's solution. It may suggest that vessels reaction depends upon the functional state of the organ and it is not directly connected with the hormones present in the blood.
Dynarowicz
I
I
Zakład Farmakologii, Instytut Podstawowych Nauk Weterynaryjnych, Akademia Rolniczo-Techniczna w Olsztynie
Watkowski
T
T
Dziegielewski
M
M
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D015306:Biogenic Monoamines / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects / Q000502:physiology; D005260:Female; D066298:In Vitro Techniques; D010053:Ovary / Q000098:blood supply* / Q000187:drug effects; D010909:Pituitary Hormones, Posterior / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D013552:Swine / Q000502:physiology*; D014599:Uterus / Q000098:blood supply* / Q000187:drug effects
D015306:Biogenic Monoamines; D010909:Pituitary Hormones, Posterior; D000804:Angiotensin II
Analiza wpływu oksytocyny, wazopresyny, angiotensyny, serotoniny i histaminy na przepływ krwi w narzadzie rozrodczym świń w przebiegu cyklu płciowego.