[Evaluation of deferoxamine capacity to revert a severe porphyria induced by hexachlorobenzene].
The purpose of the present work is to investigate the ability of desferrioxamine (DF) as an iron chelator to revert or decrease a severe experimental porphyria induced by hexachlorobenzene (HCB) in rats; DF treatment started after 17 weeks of HCB intoxication and was continued until the 27th week. The urinary excretions of -aminolevulinic acid (ALA), porphobilinogen and porphyrins were weekly quantitated. At the end of the experiment the animals were sacrificed and hepatic porphyrins, ALA-synthase and porphyrinogen carboxy-lyase activities were determined. The results obtained indicated that, under the present conditions, the administered iron chelator does not improve the disturbance promoted by HCB on the haem pathway. These results were compared with those obtained when the DF was given simultaneously with HCB from the beginning of fungicide administration. In this last situation the chelator was able to delay and diminish the porphyrinogenic effect of HCB.
Wainstok de Calmanovici
R
R
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Billi
S C
SC
Aldonatti
C A
CA
San Martín de Viale
L C
LC
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism / Q000652:urine; D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism; D003676:Deferoxamine / Q000627:therapeutic use*; D006581:Hexachlorobenzene; D008099:Liver / Q000201:enzymology; D011162:Porphobilinogen / Q000652:urine; D011164:Porphyrias / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology / Q000652:urine; D011166:Porphyrins / Q000378:metabolism / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012074:Remission Induction; D012871:Skin Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology / Q000652:urine
D011166:Porphyrins; D006581:Hexachlorobenzene; D011162:Porphobilinogen; D000624:5-Aminolevulinate Synthetase; D002262:Carboxy-Lyases; C022430:porphyrinogen carboxy-lyase; D003676:Deferoxamine
Evaluación de la capacidad de la desferrioxamina para revertir una severa porfiria inducida por hexaclorobenceno.