title: Lack of necessity for corrections for pyloric losses and duodenogastric reflux in the performance of gastric secretory studies.
abstract: Gastric secretory studies are subject to considerable error owing to incomplete collections and to contamination by reflux of alkaline duodenal contents. Corrections for these sources of error have been defined, and they have been extensively applied in a research setting. In order to assess their utility in the performance of routine gastric secretory studies, the value of such corrections was assessed in 56 studies in patients with duodenal ulceration (10), previous surgical vagotomy (8), reflux oesophagitis (30) and primary oesophageal motility disorders (8). The effect of such corrections was small, and there were close correlations between uncorrected and corrected acid outputs in all four groups. The status of the vagal efferent gastric fibres was assessed by comparing the acid output after insulin hypoglycaemia with the maximal acid output after pentagastrin (insulin: pentagastrin ratio). The application of the corrections did not alter the conclusion regarding the assessment of vagal status in 55 of the 56 studies performed. It is concluded that such corrections are not necessary in the routine performance of gastric secretory studies.
authors.affiliation: Department of Surgery, University Hospital, Queen's Medical Centre, Nottingham, UK.
authors.forename: A L
authors.initials: AL
authors.lastname: Ogilvie
authors.forename: M
authors.initials: M
authors.lastname: Atkinson
mesh_terms: D000328:Adult; D004381:Duodenal Ulcer / Q000378:metabolism*; D004383:Duodenogastric Reflux / Q000378:metabolism*; D004935:Esophageal Diseases / Q000378:metabolism*; D005260:Female; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin / Q000008:administration & dosage; D011708:Pylorus / Q000378:metabolism
chemical_list: D007328:Insulin; D010418:Pentagastrin