title: Relation of renal thromboxane A2 production to urine flow, electrolyte excretion and plasma renin activity in control state and drug induced hypotension.
abstract: The functional importance of renal TxB2 generation in the maintenance of elevated arterial blood pressure in essential hypertension was followed in 22 patients, using the method of sustained blood pressure decrease by i.v. sodium nitroprusside infusion. Linear correlation between urinary excretion of TxB2, urine flow, and sodium excretion could be established in both control and hypotensive periods. Presumably, changes in urinary excretion of TxB2 reflect a secondary intrarenal counterregulatory response.
authors.affiliation: Second Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
authors.forename: B
authors.initials: B
authors.lastname: Székács
authors.forename: E
authors.initials: E
authors.lastname: Mohácsi
authors.forename: B
authors.initials: B
authors.lastname: Gachályi
authors.forename: K
authors.initials: K
authors.lastname: Tihanyi
authors.forename: I
authors.initials: I
authors.lastname: Juhász
mesh_terms: D000328:Adult; D001794:Blood Pressure; D004231:Diuresis; D006801:Humans; D007022:Hypotension / Q000097:blood / Q000652:urine*; D008875:Middle Aged; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000652:urine*; D013928:Thromboxane A2 / Q000652:urine*; D014563:Urodynamics
chemical_list: D013928:Thromboxane A2; D012964:Sodium; D012083:Renin