Rat LDL metabolism in the perinatal period.
In fetal rats at term LDL carries 75% of the total serum cholesterol, whereas in adult ones this value amounts to 20% only. Using a time-dependent two pool model the flux rates for LDL cholesterol can be calculated for the newborn. The data reveal that at birth the LDL cholesterol flux is 15-20 times higher than in the adult. During the first 2 h of postnatal life the FCR drops down from 0.4 at birth to values measured in the adult. Since at least 75% of LDL is of another origin than VLDL, a direct hepatic LDL synthesis is postulated for the newborn. The liver contributes to about 30% of the total LDL uptake which is mainly realized by a receptor-dependent mechanism, even though the fetus and the newborn exhibit markedly elevated LDL serum concentrations.
Dargel
R
R
Institute of Pathological Biochemistry, Medical Faculty, Friedrich Schiller University, Jena, GDR.
Plonné
D
D
Schlag
B
B
Franke
H
H
Winkler
L
L
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D005312:Fetal Blood / Q000378:metabolism; D008074:Lipoproteins / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol