Amphetamine and chlorpromazine modify cerebral insulin levels in rats.
Rats treated with chlorpromazine (CPZ) (1 mg/kg/day i.p.) experienced a marked decline in cerebral insulin levels (0.057 +/- 0.01 ng/g wet weight) with respect to a control group (0.38 +/- 0.05 ng/g wet weight), while rats given D-amphetamine bitartrate (AMPH) chronically (20 mg/kg/day p.o.) showed a rise in cerebral insulin (0.55 +/- 0.04 ng/g wet weight). Combined treatment with both drugs at the same dosages produced lower cerebral insulin levels (0.46 +/- 0.10 ng/g wet weight) than in the AMPH animals. In the groups of rats treated with CPZ and with AMPH + CPZ, there was a slight elevation in serum insulin levels. Serum glucose values did not vary.
Manzanares
J
J
Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Cantón
R
R
Grande
C
C
Benedi
J
J
Zaragozá
F
F
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002746:Chlorpromazine / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012559:Schizophrenia / Q000097:blood
D007328:Insulin; D000661:Amphetamine; D002746:Chlorpromazine