The arginine-stimulated insulin response is impaired in congenital duck hepatitis B virus infection.
Duck hepatitis B virus (DHBV) infects both A (glucagon-containing) and B (insulin-containing) islet cells. To examine the effect of this infection on islet cell function, baseline and secretagogue-augmented plasma insulin and glucagon levels as well as the pancreatic content of insulin and glucagon were compared in congenitally DHBV- and noninfected ducks. No difference in baseline plasma levels or the pancreatic content of insulin or glucagon was detected. However, the magnitude of the second phase of the biphasic arginine-stimulated insulin response was markedly diminished in infected ducks.
England
J M
JM
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104.
Halpern
M S
MS
D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D004372:Ducks; D004769:Enterovirus Infections / Q000151:congenital / Q000503:physiopathology*; D005934:Glucagon / Q000032:analysis; D006515:Hepatitis B virus; D007328:Insulin / Q000032:analysis / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000032:analysis / Q000378:metabolism; D010179:Pancreas / Q000032:analysis; D012636:Secretory Rate / Q000187:drug effects
D007328:Insulin; D005934:Glucagon; D001120:Arginine