Concentrations of isotretinoin and the arotinoid Ro 15-0778 in plasma and tissues of hamsters and rats.
The arotinoid Ro 15-0778 is a potent inhibitor of sebum secretion in rodents but not in humans, while isotretinoin (13-cis-retinoic acid, Accutane) inhibits sebum secretion in rodents and humans. The concentrations of Ro 15-0778 and isotretinoin were determined in plasma and target tissues of castrated, testosterone-stimulated hamsters after oral and topical dosing and in castrated, testosterone-stimulated rats after oral dosing. Comparison of this concentration data to that obtained in the plasma and sebum of humans after dosing with Ro 15-0778 and with isotretinoin did not explain why Ro 15-0778 was a potent inhibitor of sebum production in rodents but not in humans.
Vane
F M
FM
Dermatology Research, Hoffmann-La Roche Inc., Nutley, N.J.
Chari
S S
SS
Hurley
J F
JF
Shapiro
S S
SS
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D015474:Isotretinoin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008647:Mesocricetus; D051381:Rats; D011919:Rats, Inbred Strains; D012176:Retinoids / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D012629:Sebum / Q000378:metabolism; D012867:Skin / Q000378:metabolism
D012176:Retinoids; C053595:temarotene; D015474:Isotretinoin