title: Induction dose of propofol in children.
abstract: In a study of 144 children aged 1-12 years, attempts were made to assess the ED50 and ED90 of the intravenous induction agent, propofol. The doses required for loss of eyelash reflex and tolerance of facemask, in 50% of unpremedicated children, were 1.6 mg/kg and 2.5 mg/kg respectively. In children premedicated with oral trimeprazine the corresponding values of ED50 were 1.1 mg/kg and 2.0 mg/kg. Doses of 2.8 mg/kg in unpremedicated and 2.0 mg/kg for those who received trimeprazine were required for loss of eyelash reflex in 90% of children. This probably corresponds to an effective induction dose. Pain and movement on induction were common; the incidence was 27% and 21.5% respectively.
authors.affiliation: Queen Mary's Hospital for Children, Carshalton, Surrey.
authors.forename: D K
authors.initials: DK
authors.lastname: Patel
authors.forename: P A
authors.initials: PA
authors.lastname: Keeling
authors.forename: G B
authors.initials: GB
authors.lastname: Newman
authors.forename: P
authors.initials: P
authors.lastname: Radford
mesh_terms: D000771:Anesthesia, Intravenous / Q000009:adverse effects; D000777:Anesthetics / Q000008:administration & dosage*; D001285:Atropine; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010636:Phenols / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D011229:Preanesthetic Medication; D015742:Propofol; D014291:Trimeprazine
chemical_list: D000777:Anesthetics; D010636:Phenols; D014291:Trimeprazine; D001285:Atropine; D015742:Propofol