title: [Neonatal cystic leukomalacia. Perinatal case histories of 30 survivors].
abstract: In 30 surviving neonates, close prolonged ultrasonographic brain studies demonstrated cystic periventricular leucomalacias (CPVL) of varying degree (11 minor forms, 12 moderate forms, 7 severe forms). Clinical histories were reviewed for each case. There were 18 boys, 4 twins, 2 small-for-dates. Mean gestational age was 31 +/- 2 weeks, mean birthweight was 1532 +/- 356 g. No pregnancy was normal, but prenatal events were of a common occurrence in 26/30 cases (premature labor, toxaemia, twins...). Immediate perinatal events included cord difficulties in 5 cases (3 tight cords around the neck, 1 prolapse, 1 case where loose cord around the neck came down with the head), abruptio placentae (2), acute fetal distress (10, of which 8 were severe), Apgar scores 0-1 (9, of which 7 occurred after fetal distress and 2 were unexpected). In four cases, CPVL were of antenatal origin (already in the cystic stage on days 1-2). In 2 cases, CPVL occurred postnatally (infective shock on day 1 and day 46). Plausible mechanisms for anoxic-ischaemic lesions could only be found in 13 cases and remained unknown in the other 17. However, clinical histories suggested the following; cumulative minor events might become as damaging as single major events; "minor" fetal distresses should be scrutinized; pregnant women should be taught not to wait until late to arrive at hospital because this results in non-monitored delivery. No obvious relationship was found between the severity of known events and the degree of CPVL, but a number of pre- and perinatal periods were poorly monitored. The legal importance of early ultrasonographic studies was stressed.
authors.affiliation: Centre de Recherche de Biologie du Développement de l'Association Claude-Bernard, Paris.
authors.forename: M
authors.initials: M
authors.lastname: Monset-Couchard
authors.forename: O
authors.initials: O
authors.lastname: de Bethmann
authors.forename: N
authors.initials: N
authors.lastname: Iritz
authors.forename: J P
authors.initials: JP
authors.lastname: Relier
mesh_terms: D004678:Encephalomalacia / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007969:Leukomalacia, Periventricular / Q000175:diagnosis*; D008297:Male; D014463:Ultrasonography
vernacular_title: Leucomalacies kystiques néonatales. Anamnèse périnatale chez 30 survivants.