Plants as sources of antimalarial drugs, Part 6: Activities of Simarouba amara fruits.
Extracts prepared from Simarouba amara fruits collected in Panama have been found to be active against Plasmodium falciparum in vitro and against Plasmodium berghei in mice. Four active quassinoids have been identified as ailanthinone, 2'-acetylglaucarubinone, glaucarubinone and holacanthone.
O'Neill
M J
MJ
Department of Pharmacognosy, School of Pharmacy, University of London.
Bray
D H
DH
Boardman
P
P
Wright
C W
CW
Phillipson
J D
JD
Warhurst
D C
DC
Gupta
M P
MP
Correya
M
M
Solis
P
P
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D051379:Mice; D010176:Panama; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis*; D010962:Plasmodium berghei / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects
D000962:Antimalarials; D010936:Plant Extracts