Modulation of T-cell-mediated regulation of antibody production by interaction with specific immune complexes.
The importance of the phlogogenic effects of immune complexes in disease pathogenesis has been emphasized, but they also have a role in immunoregulation. We examined the effects of DNA: anti-DNA immune complexes, formed at different antigen:antibody ratios, on the ability of T cells to modulate DNA antibody production in vitro. We found that antigen-excess complexes promote IgM anti-DNA synthesis, whereas antibody-excess complexes favor a switch to IgG anti-DNA production. We suggest that interaction of T cells with immune complexes is an important feedback mechanism in control of the immune response.
Clough
J D
JD
Department of Rheumatic and Immunologic Disease, Cleveland Clinic Foundation, Ohio.
Calabrese
L H
LH
Budervic
S A
SA
D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000276:immunology*; D004247:DNA / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D010956:Plasmapheresis; D011948:Receptors, Antigen, T-Cell / Q000032:analysis; D011961:Receptors, Fc / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology*
D000936:Antigen-Antibody Complex; D011948:Receptors, Antigen, T-Cell; D011961:Receptors, Fc; D004247:DNA