title: Endodermal sinus (yolk sac) tumour of the liver. A case report and review of the literature.
abstract: A primary endodermal sinus tumour of the liver which developed in a 27-year-old woman is reported. The dimensions of the tumour were 11 x 11 x 9.5 cm. Most parts were friable, haemorrhagic, and necrotic. No metastasis was found, but one part of the tumour was invading the diaphragm directly. Histologically, the tumour had mainly a reticular pattern, and partly a solid pattern, and was characterized by the presence of Schiller-Duval bodies and intra- and extracellular hyaline globules. A small part of the tumour showed a polyvesicular vitelline pattern and glandular structures with enteric differentiation. Serum alpha-fetoprotein was very high (28,500 ng/ml), but carcinoembryonic antigen was within the normal range. Immunohistochemically, most of the tumour cells contained alpha-fetoprotein and alpha-1-antitrypsin. Carcinoembryonic antigen and glutathione S-transferase, which was recently proved to be a useful marker for colonic carcinoma, were detected only in the glandular part Four previously reported cases of primary endodermal sinus tumour of the liver are reviewed.
authors.affiliation: Department of Pathology, Hirosaki University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Narita
authors.forename: Y
authors.initials: Y
authors.lastname: Moriyama
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology*; D008649:Mesonephroma / Q000473:pathology*