A new prostaglandin E1 analogue (TFC-612) prevents a decrease in motor nerve conduction velocity in streptozocin-diabetic rats.
A new prostaglandin E1 analogue (TFC-612) was orally given to streptozocin-diabetic rats for 4 weeks after the induction of diabetes and its effects on motor nerve conduction velocity were studied. The compound significantly prevented a decrease of the velocity but did not reverse abnormal sorbitol and myo-inositol contents of the sciatic nerve. The results suggest that TFC-612 has a potent effect on diabetic nerve dysfunction via other mechanism than the correction of sorbitol and myo-inositol metabolisms and could be a potential compound for therapy of diabetic polyneuropathy.
Yasuda
H
H
Third Department of Medicine, Shiga University of Medical Science, Japan.
Sonobe
M
M
Hatanaka
I
I
Yamashita
M
M
Miyamoto
Y
Y
Terada
M
M
Amenomori
M
M
Kikkawa
R
R
Shigeta
Y
Y
Motoyama
Y
Y
D000527:Alprostadil / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000503:physiopathology; D007294:Inositol / Q000378:metabolism; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D009046:Motor Neurons / Q000502:physiology; D009431:Neural Conduction; D011459:Prostaglandins E, Synthetic; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000503:physiopathology; D013012:Sorbitol / Q000378:metabolism
D007328:Insulin; D011459:Prostaglandins E, Synthetic; D007294:Inositol; D013012:Sorbitol; C054546:TFC 612; D000527:Alprostadil