Histological changes caused by intralesional injection of a streptococcal preparation into bladder cancer.
OK-432, a lyophilized preparation of Streptococcus pyogenes, was cystoscopically injected into bladder cancer to destroy cancer cells and to prevent recurrences. Marked reactions occurred such as stromal edema, vascular dilation, cancer cell exfoliation, and polymorphonuclear cell infiltration, succeeded by monocyte and lymphocyte infiltration with occasional lymph follicle formation. Cancer cells were sometimes intermingled in microscopic necrotic foci. Foamy granuloma was another characteristic finding. The postoperative follow-up study showed a significantly low recurrence rate.
Fujita
K
K
Department of Urology, National Medical Center Hospital, Tokyo, Japan.
D000368:Aged; D000369:Aged, 80 and over; D001688:Biological Products / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010844:Picibanil / Q000008:administration & dosage / Q000627:therapeutic use*; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy
D001688:Biological Products; D010844:Picibanil