title: Degradation of epidermal growth factor receptors by cathepsin L-like protease: inhibition of the degradation by c-Ha-ras gene products.
abstract: Extract of NIH3T3 mouse fibroblasts contains a protease which can cleave epidermal growth factor receptor (EGF receptor). This protease was tentatively named cathepsin X and purified to near homogeneity. The characteristics of cathepsin X were similar to those of cathepsin L and the proteolytic activity of cathepsin X was inhibited by c-Ha-ras gene products.
authors.affiliation: Division of Biochemistry, Chiba Cancer Center Research Institute, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hiwasa
authors.forename: S
authors.initials: S
authors.lastname: Sakiyama
authors.forename: S
authors.initials: S
authors.lastname: Yokoyama
authors.forename: J M
authors.initials: JM
authors.lastname: Ha
authors.forename: S
authors.initials: S
authors.lastname: Noguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Bando
authors.forename: E
authors.initials: E
authors.lastname: Kominami
authors.forename: N
authors.initials: N
authors.lastname: Katunuma
mesh_terms: D000818:Animals; D056668:Cathepsin L; D002403:Cathepsins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D002478:Cells, Cultured; D003546:Cysteine Endopeptidases; D010450:Endopeptidases; D066246:ErbB Receptors / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics; D007700:Kinetics; D008565:Membrane Proteins / Q000502:physiology*; D051379:Mice; D010447:Peptide Hydrolases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D016283:Proto-Oncogene Proteins p21(ras)
chemical_list: D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D066246:ErbB Receptors; D002403:Cathepsins; D010450:Endopeptidases; D010447:Peptide Hydrolases; D003546:Cysteine Endopeptidases; D056668:Cathepsin L; C534278:Ctsl protein, mouse; D016283:Proto-Oncogene Proteins p21(ras)