title: Treatment of herpes zoster. Recombinant alpha interferon versus acyclovir.
abstract: Sixty-four patients received systemic alpha-interferon (10 million units subcutaneously daily) and 63 received systemic acyclovir (5 mg/kg body weight intravenously thrice daily) in a randomized study of acute herpes zoster. Start of healing, complete healing, development of new skin lesions in the primarily affected and in other dermatomes, and degree and duration of pain were evaluated. Both drugs proved equally clinically efficient without statistically different findings between the two groups; herpes zoster neuralgia was not prevented by either interferon or acyclovir therapy. Minor clinical side effects occurred slightly more frequently during interferon treatment and included fever and nausea. Transient and moderate leukopenia was observed in nearly all patients in the interferon group.
authors.affiliation: Department of Dermatology, Hospital Vienna Lainz, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Duschet
authors.forename: T
authors.initials: T
authors.lastname: Schwarz
authors.forename: P
authors.initials: P
authors.lastname: Soyer
authors.forename: A
authors.initials: A
authors.lastname: Henk
authors.forename: H
authors.initials: H
authors.lastname: Hausmaninger
authors.forename: F
authors.initials: F
authors.lastname: Gschnait
mesh_terms: D000212:Acyclovir / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D005334:Fever / Q000139:chemically induced; D006562:Herpes Zoster / Q000188:drug therapy*; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects / Q000627:therapeutic use*; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D011897:Random Allocation; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D007370:Interferon Type I; D011994:Recombinant Proteins; D000212:Acyclovir