Oxygen-independent bactericidal systems. Mechanisms and disorders.
Neutrophils contain microbicidal proteins packaged in numerous cytoplasmic granules. During phagocytosis, granules fuse to phagolysosomes where the granule contents contribute to the destruction and dissolution of ingested bacteria. The properties of the microbicidal proteins cathepsin G, BPI, and defensins are described and contrasted.
Lehrer
R I
RI
Department of Medicine, UCLA School of Medicine.
Ganz
T
T
Selsted
M E
ME
D000818:Animals; D023181:Antimicrobial Cationic Peptides; D001770:Blood Bactericidal Activity; D001798:Blood Proteins / Q000378:metabolism / Q000502:physiology*; D056649:Cathepsin G; D002403:Cathepsins / Q000502:physiology; D002609:Chediak-Higashi Syndrome / Q000097:blood / Q000276:immunology*; D023082:Defensins; D006801:Humans; D008565:Membrane Proteins; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D012697:Serine Endopeptidases
D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D023082:Defensins; D008565:Membrane Proteins; C021623:bactericidal permeability increasing protein; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G