Inhibitory effect of kassinin on salt intake induced by different natriorexigenic treatments in the rat.
Pulse intracerebroventricular (i.c.v.) injection of kassinin, 100-500 ng/rat, potently inhibits salt intake induced by sodium depletion. The effect appears to be selective since the same doses of kassinin do not inhibit milk intake or solid food intake. When given by continuous i.c.v. infusion kassinin elicits a clear anti-natriorexic effect at doses of 1-10 ng/min/rat. Kassinin not only suppresses sodium depletion-induced salt appetite, but it also inhibits sodium intake induced by pulse i.c.v. injection of renin or by subcutaneous (s.c.) deoxycorticosterone. Finally it also suppresses the elevated need-free intake of 1.5% NaCl in multidepleted female rats, which is not mediated by the renin-angiotensin-aldosterone system. These findings show that kassinin exerts a general suppressive effect on salt intake, irrespective of the natriorexigenic treatment. The present study suggests that the kassinin-like peptides that are endogenous to the rat brain may be involved in the behavioral regulation of extracellular body fluids in the rat by inhibiting sodium intake.
Massi
M
M
Istituto di Farmacologia, Universita' di Camerino, Italy.
Perfumi
M
M
de Caro
G
G
Epstein
A N
AN
D000818:Animals; D001066:Appetite / Q000187:drug effects*; D003900:Desoxycorticosterone / Q000494:pharmacology; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D007276:Injections, Intraventricular; D015286:Kassinin; D009842:Oligopeptides / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000494:pharmacology; D012965:Sodium Chloride / Q000008:administration & dosage*
D009842:Oligopeptides; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D015286:Kassinin; D012083:Renin