title: HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA phenotype B27,B44.
abstract: In a consecutive case study 231 patients with Crohn's disease were investigated for ankylosing spondylitis (AS) and HLA-A, B, C, DR antigen association. Eighteen patients (7.8%) had definite AS according to the New York criteria; 13 (72%) were HLA-B27 positive. The phenotype B27,B44 was seen in 8 patients (44%) compared to only 3 (1%) of 300 controls (p less than 10(-7), and 1 (0.5%) of 213 patients with Crohn's disease without AS (p less than 10(-7). We conclude that patients with the phenotype B27,B44 are highly at risk (relative risk = 68.8) for the common manifestation of Crohn's disease and AS.
authors.affiliation: Department of Gastroenterology, University of Düsseldorf, FRG.
authors.forename: J
authors.initials: J
authors.lastname: Purrmann
authors.forename: H
authors.initials: H
authors.lastname: Zeidler
authors.forename: J
authors.initials: J
authors.lastname: Bertrams
authors.forename: E
authors.initials: E
authors.lastname: Juli
authors.forename: S
authors.initials: S
authors.lastname: Cleveland
authors.forename: W
authors.initials: W
authors.lastname: Berges
authors.forename: R
authors.initials: R
authors.lastname: Gemsa
authors.forename: C
authors.initials: C
authors.lastname: Specker
authors.forename: H E
authors.initials: HE
authors.lastname: Reis
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000150:complications* / Q000276:immunology; D004198:Disease Susceptibility; D005260:Female; D015235:HLA-B Antigens / Q000032:analysis*; D015796:HLA-B27 Antigen; D059948:HLA-B44 Antigen; D015236:HLA-C Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012307:Risk Factors; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000276:immunology
chemical_list: D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D059948:HLA-B44 Antigen; D015236:HLA-C Antigens; C048767:HLA-C*02 antigen