[Effect of prostaglandins I2 and E1 on the cholesterol level in cultured smooth muscle cells from the human aorta].
Prostaglandins I2(PGI2) and E1(PGE1) (5 X 10(-7) M) reduced by 30% the content of intracellular cholesterol in cultured human aorta smooth muscle cells after 24 hrs of incubation in a medium without fetal calf serum. Total HDL, as well as HDL3 and HDL2b fractions stimulated the effect of prostaglandins on the reduction (by 50%) of cholesterol level.
Shakhov
Iu A
IuA
Lamaziere
J M
JM
Dorian
B
B
Daret
D
D
Larrue
J
J
D000328:Adult; D000527:Alprostadil / Q000494:pharmacology*; D001013:Aorta, Thoracic / Q000378:metabolism; D002478:Cells, Cultured; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D011464:Epoprostenol / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*
D008075:Lipoproteins, HDL; D002784:Cholesterol; D011464:Epoprostenol; D000527:Alprostadil
Vliianie prostaglandinov I2 i E1 na soderzhanie kholesterina v kul'ture gladkomyshechnykh kletok aorty cheloveka.