title: Impaired parasite growth and increased susceptibility to phagocytosis of Plasmodium falciparum infected alpha-thalassemia or hemoglobin Constant Spring red blood cells.
abstract: In vitro multiplication of Plasmodium falciparum in hemoglobin H or hemoglobin Constant Spring red blood cells (from homozygotes or double heterozygotes) was significantly reduced as compared with that in normal erythrocytes. The parasitized genetically abnormal red blood cells showed furthermore a high propensity for being phagocytosed by peripheral blood monocytes. Both impaired parasite growth and increased susceptibility to phagocytosis may be related to mechanisms for protection of the variants from P. falciparum infection.
authors.affiliation: Department of Biochemistry, Faculty of Science, Ramathibodi Hospital, Bangkok, Thailand.
authors.forename: Y
authors.initials: Y
authors.lastname: Yuthavong
authors.forename: P
authors.initials: P
authors.lastname: Butthep
authors.forename: A
authors.initials: A
authors.lastname: Bunyaratvej
authors.forename: S
authors.initials: S
authors.lastname: Fucharoen
authors.forename: S
authors.initials: S
authors.lastname: Khusmith
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000469:parasitology; D006447:Hemoglobin H; D006455:Hemoglobins, Abnormal / Q000235:genetics; D006579:Heterozygote; D006790:Host-Parasite Interactions; D006801:Humans; D009000:Monocytes / Q000502:physiology; D010587:Phagocytosis; D010963:Plasmodium falciparum / Q000502:physiology*; D013789:Thalassemia / Q000097:blood*
chemical_list: D006455:Hemoglobins, Abnormal; D006447:Hemoglobin H; C035541:Hemoglobin Constant Spring