title: Absence of genotoxic activity of refined smoke flavor (RSF) in two bacterial short-term tests.
abstract: The genotoxic activities of refined smoke flavor (RSF) produced in Poland and used in food processing were investigated in 2 bacterial short-term tests. Its mutagenic activity was examined in the Salmonella/histidine plate assay and its SOS-inducing capacity in the SOS Chromotest both without and with 'activation' by a rat liver homogenate. No genotoxic activity was detected using these 2 bacterial tests.
authors.affiliation: Unité de Programmation Moléculaire et Toxicologie Génétique, CNRS LA271, Institut Pasteur, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Jenek
authors.forename: P
authors.initials: P
authors.lastname: Quillardet
authors.forename: D
authors.initials: D
authors.lastname: Chomiak
authors.forename: A
authors.initials: A
authors.lastname: Borys
authors.forename: M
authors.initials: M
authors.lastname: Hofnung
mesh_terms: D000818:Animals; D004260:DNA Repair / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D005503:Food Additives / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests / Q000379:methods; D051381:Rats; D013014:SOS Response, Genetics / Q000187:drug effects*; D012486:Salmonella typhimurium / Q000187:drug effects*; D012906:Smoke / Q000032:analysis*
chemical_list: D005503:Food Additives; D012906:Smoke