title: Comparison of Roche RIA, Roche EIA, Hybritech EIA, and Abbott EIA methods for measuring carcinoembryonic antigen.
abstract: Using 600 clinical specimens, we compared the concordance of four methods for carcinoembryonic antigen: the Roche RIA (I); the Roche EIA (II); Hybritech EIA (III); and Abbott EIA (IV). EDTA-treated plasma was used for Methods I and II and serum for Methods III and IV. However, no significant difference was found between results for serum and plasma in Method II. The normal reference interval (in micrograms/L) was I (222 specimens), 1.94 +/- 1.54; II (57 specimens), 0.8 +/- 0.5; III (100 specimens), 2.94 +/- 2.47; and IV (614 specimens), less than 5.0. The precision of all four methods was acceptable. Concordance among all of the methods exceeded 90%.
authors.affiliation: Department of Clinical Chemistry, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
authors.forename: J S
authors.initials: JS
authors.lastname: Nisselbaum
authors.forename: C A
authors.initials: CA
authors.lastname: Smith
authors.forename: D
authors.initials: D
authors.lastname: Schwartz
authors.forename: M K
authors.initials: MK
authors.lastname: Schwartz
mesh_terms: D002272:Carcinoembryonic Antigen / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D011863:Radioimmunoassay / Q000379:methods; D012016:Reference Values
chemical_list: D002272:Carcinoembryonic Antigen