[Immunohistochemistry of the human fetal mesonephros with anti-human N-myc protein antibody].
Expression of a N-myc gene has been found in Wilms' tumor. N-myc protein, which is a N-myc gene product, can be detected using an anti-N-myc antibody. Paraffin sections of the fetal tissues at the seventh week of gestation were prepared for immunohistochemistry, stained by PAP method. The N-myc gene product was observed in the cells consisting of the mesonephric ductular wall. This result may suggest that Wilms' tumor is originated from the mesonephric tissue.
Kawahara
M
M
Department of Urology, Toho University School of Medicine.
Tsukahara
T
T
Nakagawa
C
C
D000595:Amino Acid Sequence; D000906:Antibodies / Q000276:immunology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008650:Mesonephros / Q000032:analysis*; D008969:Molecular Sequence Data; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011518:Proto-Oncogene Proteins / Q000032:analysis* / Q000276:immunology; D016271:Proto-Oncogene Proteins c-myc
D000906:Antibodies; D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc