Criteria to define anti-idiotypic antibodies carrying the internal image of an antigen.
Anti-idiotypic antibodies which carry the internal image of a foreign antigen, i.e. so-called Ab2 beta antibodies, have been successfully used as vaccines to pathogens, as tools to isolate cellular receptors or as reagents in cancer therapy. An attempt is made to establish structural, immunochemical and and functional criteria to define anti-idiotypic antibodies of the Ab2 beta type.
Ertl
H C
HC
Dana-Faber Cancer Institute, Harvard Medical School, Boston.
Bona
C A
CA
D000937:Antigen-Antibody Reactions; D001424:Bacterial Infections / Q000517:prevention & control / Q000628:therapy; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007167:Immunotherapy; D009369:Neoplasms / Q000628:therapy; D010272:Parasitic Diseases / Q000517:prevention & control / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology; D014612:Vaccines / Q000276:immunology; D014777:Virus Diseases / Q000517:prevention & control / Q000628:therapy
D007130:Immunoglobulin Idiotypes; D014612:Vaccines