title: Generation of homozygosity at the c-Ha-ras-1 locus on chromosome 11p in an adrenal adenoma from an adult with Wiedemann-Beckwith syndrome.
abstract: Generation of homozygosity for the human c-Ha-ras-1 locus on the short arm of chromosome #11 (11p) has been demonstrated for an adrenal adenoma from an adult with Wiedemann-Beckwith syndrome (WBS). This is the first demonstration of loss of somatic heterozygosity for a locus on 11p in an adrenal neoplasm and is the first instance where a tumor of any type, from a patient with WBS, shows loss of heterozygosity in this region of the genome. Generation of homozygosity in an adenoma, rather than a carcinoma, demonstrates that this mechanism is an early event in tumorigenesis rather than a late event associated with tumor progression.
authors.affiliation: Queensland Institute of Medical Research, Brisbane, Australia.
authors.forename: N K
authors.initials: NK
authors.lastname: Hayward
authors.forename: M H
authors.initials: MH
authors.lastname: Little
authors.forename: R H
authors.initials: RH
authors.lastname: Mortimer
authors.forename: W M
authors.initials: WM
authors.lastname: Clouston
authors.forename: P J
authors.initials: PJ
authors.lastname: Smith
mesh_terms: D000236:Adenoma / Q000150:complications / Q000235:genetics*; D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000235:genetics*; D001506:Beckwith-Wiedemann Syndrome / Q000150:complications / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D005260:Female; D011905:Genes, ras; D005819:Genetic Markers; D006720:Homozygote; D006801:Humans; D008875:Middle Aged; D011519:Proto-Oncogenes
chemical_list: D005819:Genetic Markers