Increased fibroblast colony stimulating activity (F-CSA) in serum of myeloproliferative disorders.
Sera of patients with primary myelofibrosis (PMF), primary thrombocythemia (PT), polycythaemia vera (PV) and chronic myeloid leukemia (CML) contained a significantly increased F-CSA (or F-CSAs) compared to those of normal subjects and patients with secondary thrombocytosis (ST). This F-CSA was heat sensitive and had the capacity to promote both proliferation and maturation of normal marrow fibroblast colony-forming cells (CFU-F). This F-CSA seemed to be different from human platelet derived growth factor (PDGF), tumor necrosis factor (TNF) and fibroblast growth factor (FGF) from bovine brain. This F-CSA might be of importance in the pathogenesis of bone marrow fibrosis in myeloproliferative disorders.
Han
Z C
ZC
Department of Hematology, A. Morvan Hospital, Brest University School of Medicine, France.
Briere
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J
Parent
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Abgrall
J F
JF
Sensebe
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D000818:Animals; D001854:Bone Marrow Cells; D002417:Cattle; D002455:Cell Division; D003114:Colony-Forming Units Assay; D003115:Colony-Stimulating Factors / Q000378:metabolism* / Q000494:pharmacology; D005346:Fibroblast Growth Factors / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology; D006358:Hot Temperature; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood; D009196:Myeloproliferative Disorders / Q000097:blood*; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D011087:Polycythemia Vera / Q000097:blood; D055728:Primary Myelofibrosis / Q000097:blood; D013234:Stem Cells / Q000166:cytology; D013920:Thrombocythemia, Essential / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D003115:Colony-Stimulating Factors; D010982:Platelet-Derived Growth Factor; D014409:Tumor Necrosis Factor-alpha; D005346:Fibroblast Growth Factors