title: Comparative double-blind study of tiaprofenic acid versus piroxicam in the treatment of osteoarthritis of the knee.
abstract: A double-blind, parallel-group study was carried out to compare the clinical efficacy and tolerance of tiaprofenic acid and piroxicam in 80 patients suffering from osteoarthritis of the knee. Tiaprofenic acid was administered orally at a dosage of 900 mg daily for 14 days and piroxicam at a dosage of 40 mg daily. The following parameters were assessed: spontaneous morning pain; spontaneous night pain; pain during walking; pain on passive mobilisation; pain on squatting; morning stiffness; duration of morning stiffness; local inflammatory signs; and overall mobility of the joint. All these parameters were evaluated before treatment started and at days 7 and 14. At the end of the study, the physician made an overall assessment, and the results were statistically evaluated. The results showed that in both groups of patients, the signs and symptoms improved significantly from the seventh day of the trial, but there were no significant differences between the 2 groups for any of the assessed parameters. However, the physician's overall assessment was in favour of tiaprofenic acid due to a greater number of important improvements.
authors.affiliation: Rheumatology Department, Hospital Francés, Buenos Aires.
authors.forename: A
authors.initials: A
authors.lastname: Maccagno
authors.forename: O
authors.initials: O
authors.lastname: Sebastian
authors.forename: E
authors.initials: E
authors.lastname: Di Giorgio
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D010894:Piroxicam / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011422:Propionates / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011897:Random Allocation
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; D010894:Piroxicam; C021270:tiaprofenic acid