title: Hexose metabolism in pancreatic islets stimulation by D-glucose of [2-3H]glycerol detritiation.
abstract: 1. In pancreatic islets, a rise in glucose concentration is known to increase the ratio between D-[6-14C]glucose oxidation and D-[5-3H]glucose utilization. The opposite situation was found to prevail in parotid cells. 2. In rat pancreatic islets, D-glucose caused a concentration-related stimulation of 3H2O production from [2-3H]glycerol, but failed to affect 3H2O production from [1(3)-3H]glycerol or 14CO2 production from [U-14C]glycerol. At the low concentration used in most of these experiments (i.e. 1.0 mM), glycerol failed to affect D-[U-14C]glucose oxidation. 3. These findings suggest that the preferential stimulation by D-glucose of mitochondrial oxidative events in pancreatic islets represents an unusual situation in secretory cells and involves an accelerated circulation in the glycerol phosphate shuttle.
authors.affiliation: Laboratory of Experimental Medicine, Brussels Free University, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Sener
authors.forename: J
authors.initials: J
authors.lastname: Rasschaert
authors.forename: D
authors.initials: D
authors.lastname: Zähner
authors.forename: W J
authors.initials: WJ
authors.lastname: Malaisse
mesh_terms: D000693:Anaerobiosis; D000818:Animals; D002250:Carbon Radioisotopes; D003981:Diazoxide / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D005990:Glycerol / Q000378:metabolism*; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D010306:Parotid Gland / Q000378:metabolism; D011865:Radioisotope Dilution Technique; D051381:Rats; D014316:Tritium
chemical_list: D002250:Carbon Radioisotopes; D014316:Tritium; D005947:Glucose; D003981:Diazoxide; D005990:Glycerol