Yq deletion and failure of spermatogenesis.
The spermatogenesis of a sterile male carrying a Y long arm deletion was analyzed by meiotic techniques and by light and electron microscopy on testicular biopsies. R-, Q- and C- banding techniques have shown that the Y long arm deletion included the entire heterochromatin and a part of the euchromatic region, with breakpoint between q11.21 and q11.23. The seminiferous tubules showed a sharp decrease in spermatogonia, degenerative phenomena in their nuclei and a spermatogenic block. Abnormal meiotic aspects were observed: pairing failure with atypical diakinesis configurations. These findings confirm the presence of spermatogenesis controlling factors on the distal euchromatic region of the Y long arm.
Hartung
M
M
Laboratoire de Génétique, Faculté de Médecine, Marseille.
Devictor
M
M
Codaccioni
J L
JL
Stahl
A
A
D000328:Adult; D002872:Chromosome Deletion; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008540:Meiosis; D013091:Spermatogenesis; D013093:Spermatogonia / Q000648:ultrastructure; D013737:Testis / Q000473:pathology / Q000648:ultrastructure; D014998:Y Chromosome