Enhancement by alloxan-induced diabetes of the rate of metabolic activation of three pyrolysate carcinogens via increase in the P-448-H content in rat liver.
Yamazoe
Y
Y
Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan.
Abu-Zeid
M
M
Yamauchi
K
K
Murayama
N
N
Shimada
M
M
Kato
R
R
D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D002273:Carcinogens / Q000378:metabolism*; D019388:Cytochrome P-450 CYP1A2; D003580:Cytochromes / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D007093:Imidazoles / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D007538:Isoniazid / Q000494:pharmacology; D008862:Microsomes, Liver / Q000378:metabolism*; D009152:Mutagenicity Tests; D051381:Rats
D002273:Carcinogens; D003580:Cytochromes; D007093:Imidazoles; D007328:Insulin; C017170:Cyp1a2 protein, rat; D019388:Cytochrome P-450 CYP1A2; D007538:Isoniazid