title: [Mechanisms of insulin resistance in pregnancy].
abstract: The causes of insulin resistance were studied in rats at late terms of pregnancy. A decrease in the sensitivity to insulin dependent incorporation of glucose in total lipids and CO2 of isolated fatty tissue of pregnant rats was shown. The maximum tissue reaction to insulin (reactivity) did not lessen indicating together with hyperinsulinemia after a glucose tolerance test and a rise of the activity of blood serum insulin-like growth factors the absence of postreceptor defects. An increase in the pregnant rats blood levels of cholesterol, triglycerides and lipoprotein atherogenic fractions was revealed. The latter in physiological concentrations made an inhibitory effect on respiration of liver and thyroid sections of intact rats. Together with the action of hormones of the fetoplacental system it was considered as one of the mechanisms of development of insulin resistance at late terms of pregnancy.
authors.forename: M I
authors.initials: MI
authors.lastname: Kosovskiĭ
authors.forename: S P
authors.initials: SP
authors.lastname: Katkova
authors.forename: T D
authors.initials: TD
authors.lastname: Saipov
authors.forename: M M
authors.initials: MM
authors.lastname: Mirakhmedov
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003345:Corticosterone / Q000097:blood; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D005951:Glucose Tolerance Test; D007328:Insulin / Q000008:administration & dosage / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D010052:Ovariectomy; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood / Q000187:drug effects*; D051381:Rats; D013002:Somatomedins / Q000097:blood; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D008074:Lipoproteins; D013002:Somatomedins; D005947:Glucose; D003345:Corticosterone
vernacular_title: O mekhanizmakh insulinrezistentnosti pri beremennosti.