Strain variation in the frequency of Abelson murine leukemia virus-transformed fetal liver pre-B cells bearing complete immunoglobulin heavy chain rearrangements.
Fetal liver Abelson pre-B cell lines obtained from CBA/Tufts.xid and (CBA/Tufts.xid x CBA/Tufts)F1 mice have complete VDJH rearrangements on at least one allele. Such high frequencies of VDJH rearrangements have previously been observed in adult derived but not fetal liver derived Abelson pre-B cell lines. Genetic analyses suggest that CBA/Tufts.xid carries an autosomal dominant gene(s) that determines the predominance of VDJH rearrangements among transformants. This autosomal gene(s) might affect the intrinsic development of the early B cell lineage in the fetus or the fetal microenvironment, expanding pre-B cells of the "more mature" VDJH phenotype.
Osman
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GE
Immunology Program, Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts.
Wortis
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HH
Brodeur
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PH
D000011:Abelson murine leukemia virus; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002472:Cell Transformation, Viral; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D008040:Genetic Linkage; D007153:Immunologic Deficiency Syndromes / Q000235:genetics; D008099:Liver / Q000196:embryology*; D051379:Mice; D008815:Mice, Inbred Strains; D013234:Stem Cells / Q000276:immunology; D014960:X Chromosome