title: B lymphocytic lymphoma (large cell) of possible splenic marginal zone origin presenting with prominent splenomegaly and unusual cordal red pulp distribution.
abstract: Two cases of large cell lymphoma, B-cell type, primarily involving the red pulp of the spleen rather than the white pulp are described. A number of unusual features suggest that this may be a lymphoma originating from a distinct splenic B-cell lymphocyte whose origin may be the marginal zone of the spleen or the splenic cords. The patients presented with splenomegaly, cytopenias, and no peripheral lymphadenopathy. The gross appearance of the spleens was beefy red without tumor nodules. The tumor cells were primarily in the splenic cords and surrounding residual normal white pulp. There was a minimal hemic phase. The tumor cells had abundant cytoplasm, surface IgM, IgD, kappa, and FC receptors, tartrate-resistant acid phosphatase, but no alkaline phosphatase or interleukin-2 receptors. They had a similar DNA aneuploidy. The most unusual feature was that tumor cells in both cases had phagocytic properties. These lymphomas may be clinically more indolent than their follicular center counterparts.
authors.affiliation: Wayne State University School of Medicine, Department of Pathology, Berman Memorial Laboratories, Detroit, Michigan 48201.
authors.forename: M
authors.initials: M
authors.lastname: Palutke
authors.forename: L
authors.initials: L
authors.lastname: Eisenberg
authors.forename: S
authors.initials: S
authors.lastname: Narang
authors.forename: L L
authors.initials: LL
authors.lastname: Han
authors.forename: T C
authors.initials: TC
authors.lastname: Peeples
authors.forename: D L
authors.initials: DL
authors.lastname: Kukuruga
authors.forename: P M
authors.initials: PM
authors.lastname: Tabaczka
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000166:cytology; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D013160:Splenic Neoplasms / Q000175:diagnosis / Q000473:pathology*; D013163:Splenomegaly
chemical_list: D004273:DNA, Neoplasm