In vivo dopaminergic neurotoxicity of the 2-beta-methylcarbolinium ion, a potential endogenous MPP+ analog.
The MPP+-like neurotoxicity of the 2-methyl-beta-carbolinium species, a possible endogenous condensation product structurally related to MPP+, has been assessed by an intracerebral microdialysis technique. Although much less potent, this compound appears to cause the selective and irreversible destruction of nigrostriatal nerve terminals in rat brain in a manner similar to that observed under comparable conditions with MPP+.
Rollema
H
H
Department of Pharmaceutical Chemistry, University of California, San Francisco 94143.
Booth
R G
RG
Castagnoli
N
N
D015655:1-Methyl-4-phenylpyridinium; D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D002243:Carbolines / Q000633:toxicity*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D003956:Dialysis; D004298:Dopamine / Q000378:metabolism; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced*; D011726:Pyridinium Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology*
D002243:Carbolines; D011726:Pyridinium Compounds; D011954:Receptors, Dopamine; D015102:3,4-Dihydroxyphenylacetic Acid; D015655:1-Methyl-4-phenylpyridinium; D004298:Dopamine