Appearance of hybridoma growth factor/interleukin-6 in the serum of mice bearing a methylcholanthrene-induced sarcoma.
Serum concentrations of hybridoma growth factor/interleukin-6 progressively increased in mice bearing a transplantable methylcholanthrene-induced sarcoma with tumor growth. Elevated HGF/interleukin-6 concentrations were also positively correlated with increased serum concentrations of the hepatic acute phase reactant protein, amyloid P. Daily Indomethacin treatment of sarcoma-bearing mice prolonged survival and reduced the magnitude of the serum amyloid P response, but failed to attenuate either tumor growth or serum HGF/interleukin-6 responses. Since previous studies have demonstrated that neither interleukin-1 nor tumor necrosis factor-alpha can be detected in the serum of these sarcoma-bearing mice, and that HGF/interleukin-6 is a principal mediator of the hepatic acute phase response, we conclude that circulating HGF/interleukin-6 may contribute significantly to the host responses which accompany experimentally-introduced cancer. Furthermore, prostanoid inhibition does not appear to regulate the synthesis and release of HGF/interleukin-6 during tumor growth.
Gelin
J
J
Department of Surgery I, University of Gothenburg, Sweden.
Moldawer
L L
LL
Lonnroth
C
C
deMan
P
P
Svanborg-Eden
C
C
Lowry
S F
SF
Lundholm
K G
KG
D000818:Animals; D007213:Indomethacin / Q000494:pharmacology; D015850:Interleukin-6; D007378:Interleukins / Q000096:biosynthesis*; D051379:Mice; D012513:Sarcoma, Experimental / Q000378:metabolism*; D000683:Serum Amyloid P-Component / Q000097:blood; D013997:Time Factors
D015850:Interleukin-6; D007378:Interleukins; D000683:Serum Amyloid P-Component; D007213:Indomethacin