title: Diagnostic value of elastase-alpha 1-proteinase inhibitor in cerebrospinal fluid.
abstract: In this report we introduce CSF Elastase-alpha 1-Proteinase inhibitor as a valuable indicator for differentiating bacterial meningitis from aseptic meningitis and other neurological disorders. All patients (n = 26) with bacterial meningitis had increased CSF concentrations of E-alpha 1-PI above the range of normal (range of reference values: 0.0-2.3 micrograms/l, n = 79; bacterial meningitis: 30-3490 micrograms/l, n = 26). Concentrations of E-alpha 1-PI in bacterial meningitis were significantly elevated when compared with those in aseptic meningitis (0.0-194 micrograms/l, n = 37), polyneuropathy (0-23 micrograms/l, n = 24) and cerebrovascular attack (0-23.2 micrograms/l, n = 17).
authors.affiliation: Department of Pediatrics, University of Göttingen, West Germany.
authors.forename: C P
authors.initials: CP
authors.lastname: Speer
authors.forename: C
authors.initials: C
authors.lastname: Rocchetti
authors.forename: M
authors.initials: M
authors.lastname: Rethwilm
authors.forename: W
authors.initials: W
authors.lastname: Hohenwallner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000134:cerebrospinal fluid*; D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000201:enzymology / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000201:enzymology* / Q000276:immunology; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism; D000515:alpha 1-Antitrypsin
chemical_list: D001798:Blood Proteins; D000515:alpha 1-Antitrypsin