Complete C4B deficiency in black Americans with systemic lupus erythematosus.
We report 3 black American patients with systemic lupus erythematosus (SLE) in whom C4B was completely deficient in plasma. They all exhibited antibody against the nucleoprotein antigen SSA (Ro), as well as cutaneous involvement, features that have been previously associated with complement deficiency states. IgG antibody against cardiolipin was also present in 2 patients, in association with a biologic false positive test for syphilis in one patient, and with thrombocytopenia in another. This is the first description of the clinical presentation of complete C4B deficiency in blacks with SLE.
Wilson
W A
WA
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
Perez
M C
MC
D000328:Adult; D000974:Antibodies, Antinuclear / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001324:Autoantigens / Q000276:immunology; D044383:Black People; D002308:Cardiolipins / Q000276:immunology; D003181:Complement C4 / Q000172:deficiency*; D015935:Complement C4b; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D008875:Middle Aged; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D012871:Skin Diseases / Q000276:immunology; D001741:Black or African American; D000099207:SS-A Antigen
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D001324:Autoantigens; D002308:Cardiolipins; D003181:Complement C4; D015935:Complement C4b; D007074:Immunoglobulin G; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human