Augmentation of critical skin flap survival following ibuprofen therapy.
Much research effort has attempted to identify pharmacological agents that will augment random skin flap survival. Unfortunately, the vast majority of these agents have been administered preoperatively, and as such their routine use is not often justified. Ibuprofen administered in the postoperative period significantly augments random skin flap survival in the rat.
Nichter
L S
LS
Division of Plastic and Reconstructive Surgery, University of Southern California Medical Center, Los Angeles.
Sobieski
M W
MW
Edgerton
M T
MT
D000818:Animals; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D007052:Ibuprofen / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013524:Surgical Flaps
D007052:Ibuprofen