[Are cephalosporins more active than penicillin G in poisoning with the deadly Amanita?].
High dose penicillin-G has been found empirically to be effective against liver cell damage in amanita mushroom poisoning. We have recently found that betalactam antibiotics inhibit eukaryotic DNA polymerase-alpha, penicillins being more active than cephalosporins, and this may explain the antagonistic effect of penicillin-G against amanitin toxicity. Preliminary experiments in liver cell cultures and in mice are summarized, as well as first clinical experience pointing to the possibility that cephalosporins may be more effective against amanita mushroom toxicity than penicillin-G.
Neftel
K
K
Departement für Innere Medizin, Universitätsspital Zürich.
Keusch
G
G
Cottagnoud
P
P
Widmer
U
U
Hany
M
M
Gautschi
K
K
Joos
B
B
Walt
H
H
D000818:Animals; D002442:Ceftazidime / Q000627:therapeutic use; D002478:Cells, Cultured; D002511:Cephalosporins / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D002642:Chick Embryo; D006801:Humans; D051379:Mice; D009145:Mushroom Poisoning / Q000150:complications / Q000188:drug therapy*; D010400:Penicillin G / Q000627:therapeutic use*
D002511:Cephalosporins; D002442:Ceftazidime; D010400:Penicillin G
Sind Cephalosporine bei der Intoxikation mit Knollenblätterpilz besser wirksam als Penicillin-G?