title: Regulation of H-2 class I gene expression in virally transformed and infected cells.
abstract: Early studies of the resistance and susceptibility of mouse strains to radiation-induced leukemia virus have demonstrated the important role of altered histocompatibility (H-2) antigen expression in the effectiveness of the immune response of the host to virus-infected and transformed cells. Changes in H-2 gene expression have now been correlated with disease resistance in a variety of viral systems. The experiments discussed indicate that viruses may directly or indirectly affect H-2 antigen expression at various levels of gene expression. These investigations generate a framework for approaching a molecular understanding of viral-induced changes in H-2 gene expression.
authors.affiliation: Department of Pathology, New York University Medical Center, New York.
authors.forename: G D
authors.initials: GD
authors.lastname: Brown
authors.forename: Y
authors.initials: Y
authors.lastname: Choi
authors.forename: C
authors.initials: C
authors.lastname: Pampeno
authors.forename: D
authors.initials: D
authors.lastname: Meruelo
mesh_terms: D000818:Animals; D002472:Cell Transformation, Viral; D005786:Gene Expression Regulation; D005805:Genes, MHC Class I; D006183:H-2 Antigens / Q000235:genetics*; D007942:Leukemia, Experimental / Q000235:genetics / Q000276:immunology; D051379:Mice; D012190:Retroviridae / Q000235:genetics; D014412:Tumor Virus Infections / Q000235:genetics / Q000276:immunology
chemical_list: D006183:H-2 Antigens