[Effects of regimens of total body irradiation on interstitial pneumonitis after bone marrow transplantation].
Data from 224 patients with leukemia who received TBI followed with allogeneic BMT between 1975 and 1985 were retrospectively analyzed to determine the effects of dose-fractionation factors on the incidences of interstitial pneumonitis (IP). Among several factors examined, the fraction size most predominantly correlated with the IP rate. The selection of the optimal dose rate adjusted to the fraction size also contributed to decreasing the rate of the IP. The total lung dose significantly correlated with the IP rate on a single dose, and the fractionated TBI with a high fraction dose. The dose-response curves of idiopathic IP, derived by a multivariate analyses using the three factors mentioned above, have been presented.
Sugawara
T
T
Dept. of Radiotherapy, Jichi Medical School.
Inoue
T
T
Mori
T
T
Iino
Y
Y
Masaoka
T
T
D016026:Bone Marrow Transplantation; D006801:Humans; D007938:Leukemia / Q000532:radiotherapy / Q000628:therapy*; D011658:Pulmonary Fibrosis / Q000209:etiology*; D011879:Radiotherapy Dosage; D012307:Risk Factors; D014916:Whole-Body Irradiation / Q000009:adverse effects