Analysis of dose-response curves for the in vitro susceptibility of Plasmodium falciparum to antimalarials using a pocket computer.
A small pocket computer, Sharp PC-1500, was programmed to analyze the dose-response curves generated by the in vitro assay of antimalarials against field isolates of Plasmodium falciparum. Using nonlinear regression the analysis provided an estimate of the 50% inhibitory concentration with 95% confidence limits and a graph of the data points and regression function line. The pocket computer with the nonlinear regression program offers a powerful, portable, and inexpensive data analysis system suitable for field use.
Childs
G E
GE
Armed Forces Research Institute, Medical Sciences, Bangkok, Thailand.
Pang
L
L
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D003201:Computers; D004305:Dose-Response Relationship, Drug; D008838:Microcomputers; D010963:Plasmodium falciparum / Q000187:drug effects*; D012044:Regression Analysis; D012984:Software
D000962:Antimalarials