In vivo effect of 1 alpha-hydroxyvitamin D3 on interleukin-2 production in hemodialysis patients.
The immunoregulatory effect of 1 alpha-OHD3, a precursor form of active vitamin D3 1,25 (OH)2D3, was examined in hemodialysis patients. Peripheral blood mononuclear cells (PBM) from hemodialysis patients produced significantly less interleukin-2 (IL-2) than those from normal controls. Four weeks of oral administration of 0.5 micrograms/day of 1 alpha-OHD3 enhanced the IL-2 production of PBM from the patients. This fact suggests that 1 alpha-OHD3 therapy may be useful for the restoration of IL-2 production in hemodialysis patients, and that the vitamin D3 deficiency may be responsible for the impairment of cellular immunity associated with IL-2 production disorder in hemodialysis patients.
Tabata
T
T
Inoue Hospital, Osaka, Japan.
Shoji
T
T
Kikunami
K
K
Matsushita
Y
Y
Inoue
T
T
Tanaka
S
S
Hino
M
M
Miki
T
T
Nishizawa
Y
Y
Morii
H
H
D000328:Adult; D000368:Aged; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000097:blood; D002478:Cells, Cultured; D006801:Humans; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000276:immunology / Q000628:therapy; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D006435:Renal Dialysis
D006887:Hydroxycholecalciferols; D007376:Interleukin-2; D010281:Parathyroid Hormone; D010710:Phosphates; D002117:Calcitriol; D002118:Calcium; C008088:alfacalcidol