Cerebral germinomas and Klinefelter syndrome. A review.
Patients with Klinefelter syndrome appear to be predisposed to the development of extragonadal cerebral germinomas. A case of a pineal region germinoma in a boy 15 years of age with Klinefelter syndrome is documented in this article. In view of three other cases of cerebral germinomas associated with Klinefelter syndrome in the literature, a hypothesis for this predisposition is suggested.
Arens
R
R
Department of Pediatrics B, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Marcus
D
D
Engelberg
S
S
Findler
G
G
Goodman
R M
RM
Passwell
J H
JH
D000293:Adolescent; D001932:Brain Neoplasms / Q000209:etiology*; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications*; D008297:Male; D010871:Pinealoma / Q000209:etiology*