title: Gastrin responses in patients with adrenergic insufficiency.
abstract: High basal gastrin levels in pure autonomic failure could result from peripheral vagus nerve involvement, whereas the increased response during hypoglycaemia may reflect adrenergic supersensitivity. A reduced gastrin increment in multiple system atrophy was found following insulin-hypoglycaemia and is consistent with decreased gastrin release secondary to diminished central sympathetic nervous system activation in the absence of peripheral denervation supersensitivity.
authors.affiliation: Clinical Neuropharmacology Section, N.I.N.C.D.S., Bethesda, MD 20892.
authors.forename: R J
authors.initials: RJ
authors.lastname: Polinsky
authors.forename: I L
authors.initials: IL
authors.lastname: Taylor
authors.forename: V
authors.initials: V
authors.lastname: Weise
authors.forename: I J
authors.initials: IJ
authors.lastname: Kopin
mesh_terms: D000328:Adult; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000503:physiopathology*; D001786:Blood Glucose / Q000378:metabolism; D004837:Epinephrine / Q000097:blood; D005260:Female; D005755:Gastrins / Q000097:blood*; D006801:Humans; D007003:Hypoglycemia / Q000503:physiopathology; D007024:Hypotension, Orthostatic / Q000503:physiopathology; D007328:Insulin; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D013270:Stomach / Q000294:innervation*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
chemical_list: D001786:Blood Glucose; D005755:Gastrins; D007328:Insulin; D009638:Norepinephrine; D004837:Epinephrine