title: Accuracy of ultrasound diagnoses in pregnancies complicated by suspected fetal anomalies.
abstract: Referral of pregnancies complicated by suspected fetal anomalies to level III perinatal centres for further evaluation and management is increasing as use of real-time ultrasound spreads, but the sensitivity and specificity of the prenatal diagnoses made in this population are unknown. We undertook a prospective study that followed pregnancies referred to a designated programme dealing with suspected fetal abnormalities. Follow-up of 257 pregnancies revealed that 282 separate anomalies were accurately diagnosed in 212 cases. Normal anatomy was correctly predicted in 42 cases, 16 per cent of the referred population. False-positive and false-negative rates were 1.5 per cent (4/257) and 2 per cent (1/46), respectively. However, 37 per cent of those infants born with anomalies had additional problems not prenatally detected by ultrasound. These results indicate that prenatal ultrasound diagnoses are remarkably accurate overall but that they may be insensitive to associated anomalies in individual cases.
authors.affiliation: Department of Pediatrics, University of Colorado School of Medicine, Denver.
authors.forename: D K
authors.initials: DK
authors.lastname: Manchester
authors.forename: D H
authors.initials: DH
authors.lastname: Pretorius
authors.forename: C
authors.initials: C
authors.lastname: Avery
authors.forename: M L
authors.initials: ML
authors.lastname: Manco-Johnson
authors.forename: J
authors.initials: J
authors.lastname: Wiggins
authors.forename: P R
authors.initials: PR
authors.lastname: Meier
authors.forename: W H
authors.initials: WH
authors.lastname: Clewell
mesh_terms: D000013:Congenital Abnormalities / Q000150:complications / Q000175:diagnosis*; D005069:Evaluation Studies as Topic; D005260:Female; D005315:Fetal Diseases / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D010347:Patient Care Planning / Q000458:organization & administration; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D014463:Ultrasonography / Q000592:standards*