Chromosomal localization of the hst oncogene and its co-amplification with the int.2 oncogene in a human melanoma.
In this report we described the linkage between two oncogenes of the fibroblast growth factor family. Using in situ hybridization to human metaphase chromosomes we mapped the hst gene to chromosome 11 at band q13. This is also the location of the int.2 gene. Furthermore, the two genes are co-amplified in a human melanoma, raising the possibility that amplification in human tumors may be a mechanism of activation of genes of the FGF family.
Adelaide
J
J
Unité 119 de l'INSERM, Marseille, France.
Mattei
M G
MG
Marics
I
I
Raybaud
F
F
Planche
J
J
De Lapeyriere
O
O
Birnbaum
D
D
D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D004273:DNA, Neoplasm / Q000032:analysis; D005784:Gene Amplification; D005786:Gene Expression Regulation; D006801:Humans; D008545:Melanoma / Q000235:genetics*; D005810:Multigene Family; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D004273:DNA, Neoplasm; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins