Ribavirin small-particle-aerosol treatment of influenza B virus infection.
In a randomized double-blind trial of aerosolized ribavirin for the treatment of influenza B virus infection, no significant difference was found in the febrile course or symptom score of the ribavirin-treated versus placebo-treated patients. The apparent lack of efficacy in this study as compared with that in previous studies is unexplained.
Bernstein
D I
DI
Clinical Virology Division, James N. Gamble Institute of Medical Research, Cincinnati, Ohio 45219.
Reuman
P D
PD
Sherwood
J R
JR
Young
E C
EC
Schiff
G M
GM
D000328:Adult; D000336:Aerosols; D001831:Body Temperature; D002986:Clinical Trials as Topic; D004196:Disease Outbreaks; D004311:Double-Blind Method; D006801:Humans; D009981:Influenza B virus / Q000254:growth & development; D007251:Influenza, Human / Q000188:drug therapy*; D011897:Random Allocation; D012254:Ribavirin / Q000008:administration & dosage / Q000627:therapeutic use*; D012263:Ribonucleosides / Q000627:therapeutic use*
D000336:Aerosols; D012263:Ribonucleosides; D012254:Ribavirin