Progress of renal dysfunction in inhabitants environmentally exposed to cadmium.
The reversibility of beta 2-microglobulinuria, glucosuria, and aminoaciduria was examined in 74 inhabitants (32 males and 42 females) over 50 yr of age, who lived in a cadmium-polluted area. The subjects participated in two examinations conducted just after the cessation of cadmium exposure and 5 yr later. All urinary parameters did not show reversible changes. During the 5 yr the geometric mean concentrations of beta 2-microglobulinuria, glucosuria, and aminoaciduria indicated significant increases in excretion. In cases where greater than 1,000 micrograms/g creatinine of beta 2-microglobulinuria was observed (at the time cadmium exposure ended), almost all individuals exposed to cadmium showed deterioration of beta 2-microglobulinuria, whereas in the case of less than 1,000 micrograms/g creatinine of beta 2-microglobulinuria, no significant changes were observed. The present study indicates that cadmium-induced renal dysfunction in individuals environmentally exposed to cadmium is irreversible.
Kido
T
T
Department of Hygiene, Kanazawa Medical University, Ishikawa, Japan.
Honda
R
R
Tsuritani
I
I
Yamaya
H
H
Ishizaki
M
M
Yamada
Y
Y
Nogawa
K
K
D000368:Aged; D002105:Cadmium Poisoning / Q000652:urine*; D004781:Environmental Exposure; D005260:Female; D006029:Glycosuria / Q000652:urine; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000652:urine; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D000608:Renal Aminoacidurias / Q000652:urine; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000652:urine
D001613:beta 2-Microglobulin