title: 5-Fluorouracil-associated cardiotoxicity.
abstract: Cardiotoxicity manifested as myocardial ischemia is not generally recognized as a side effect of 5-fluorouracil. However, there have been at least 35 cases reported since 1975. In only one of these cases was a somewhat detailed evaluation done to rule out underlying coronary disease. The case reported here of 5-FU cardiotoxicity included an extensive cardiac evaluation to rule out underlying coronary disease and to assess spasm. The literature on 5-FU cardiotoxicity is also reviewed, and its possible mechanisms are analyzed.
authors.affiliation: Division of Medical Oncology, University of Massachusetts Medical School, Worcester 01605.
authors.forename: N J
authors.initials: NJ
authors.lastname: Freeman
authors.forename: M E
authors.initials: ME
authors.lastname: Costanza
mesh_terms: D004562:Electrocardiography; D005472:Fluorouracil / Q000009:adverse effects* / Q000493:pharmacokinetics; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005472:Fluorouracil