[Tumor heterogeneity and the mechanisms of natural resistance in the metastatic process].
Data from literature concerning differences in cell populations between the primary and metastatic tumours are generalized. Their properties are considered as dependent on heterogeneity of the cell composition, karyotype, cell surface peculiarities and oncogene expression. The problem of the dependence of the ability of tumours to metastasize on their interaction with macrophages and natural killer cells is under discussion.
Kiseleva
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EG
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D009857:Oncogenes; D010641:Phenotype
Geterogennost' opukholi i mekhanizmy estestvennoĭ rezistentnosti pri metastazirovanii.