Effect of hydrocortisone and interleukins 1 and 2 on eosinophil progenitors in hypereosinophilic states.
The growth of eosinophil progenitors (CFU-Eo) and its modulation by hydrocortisone (HC), mononuclear cells, interleukin 1 (IL-1), and interleukin 2 (IL-2) in three cases of eosinophilia are reported in this paper. One microM HC decreased the proportion of CFU-Eo in each of these three patients, and in each case, the addition of autologous mononuclear cells at a 1:1 ratio abrogated the effect of HC on CFU-Eo. As studied in two of the three cases, IL-1 and IL-2 were able to prevent the effect of HC. Further studies showed no effect of HC when monocyte T cell-depleted marrow cells were used as the target population. These results suggest that CFU-Eo production in eosinophilic states is subject to modulation by HC and T lymphocytes.
Liesveld
J L
JL
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Abboud
C N
CN
Slovick
F T
FT
Rowe
J M
JM
Brennan
J K
JK
D000328:Adult; D003114:Colony-Forming Units Assay; D004802:Eosinophilia / Q000473:pathology*; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D007375:Interleukin-1 / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged
D007375:Interleukin-1; D007376:Interleukin-2; D006854:Hydrocortisone