Monoclonal antibodies for organ transplantation: prospects for the future.
Monoclonal antibodies (MoAbs) have the potential to facilitate the induction of transplantation tolerance. Realization of this potential requires both a better understanding of the cellular events concerned with rejection and tolerance, and a more detailed approach to improving antibodies for therapy. This report reviews work in our laboratory directed toward these goals.
Waldmann
H
H
Department of Pathology, New Addenbrookes Hospital, Cambridge, England.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D006084:Graft Rejection; D006801:Humans; D007108:Immune Tolerance; D051379:Mice; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D014180:Transplantation / Q000379:methods* / Q000639:trends; D014181:Transplantation Immunology
D000911:Antibodies, Monoclonal