Transcending the impenetrable: how proteins come to terms with membranes.
In the living cell, proteins are efficiently sorted to a whole range of subcellular compartments. In many cases, sorting specificity is mediated by short 'sorting signals' attached either permanently or transiently to the protein. At long last, a fairly coherent picture of the design and function of many such sorting signals is beginning to emerge.
von Heijne
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Department of Molecular Biology, Karolinska Institutet, Huddinge University Hospital, Sweden.
D000465:Algorithms; D002451:Cell Compartmentation; D002462:Cell Membrane / Q000378:metabolism*; D008051:Lipid Bilayers / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D021382:Protein Sorting Signals / Q000502:physiology; D011506:Proteins / Q000378:metabolism*
D008051:Lipid Bilayers; D008563:Membrane Lipids; D021382:Protein Sorting Signals; D011506:Proteins