Investigation of the skin thinning effect of prednicarbate and other corticoids in mouse skin.
In this investigation skin fold thinning was determined after topical application of several potent corticosteroids in hairless mice using a simple mechanical measuring device. The skin thinning effect of prednicarbate was compared with other corticosteroids (amcinonide, beta-methasone-17-valerate, clobetasol-17-propionate, diflorasone-17,21-diacetate, hydrocortisone-21-acetate). Prednicarbate produced a clear thinning of skin. Like other tested dermatocorticoids prednicarbate caused a significant atrophy of the mouse tail epidermis. By prednicarbate the 3H-thymidine triphosphate incorporation into epidermal DNA was inhibited.
Lubach
D
D
Department of Dermatology, Hautklinik Linden, Medizinische Hochschule Hannover, FRG.
Kietzmann
M
M
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D005260:Female; D006639:Histidine / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D051379:Mice; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D012867:Skin / Q000033:anatomy & histology* / Q000187:drug effects; D013936:Thymidine / Q000378:metabolism
D000305:Adrenal Cortex Hormones; D000596:Amino Acids; D000893:Anti-Inflammatory Agents; D006639:Histidine; D004247:DNA; D011239:Prednisolone; D007930:Leucine; C035287:prednicarbate; D013936:Thymidine