Retinal toxicity study of intravitreal carboplatin and iproplatin.
We tested the intravitreal toxicity of two second-generation, antineoplastic, platinum-coordination compounds, carboplatin and iproplatin, in the rabbit. No histologic or electroretinographic changes were observed in doses of 3 micrograms or less. These analogues of cisplatin are 30 times less toxic than the parent compound and may be useful in the prevention of cell proliferation in the vitreous.
Zlioba
A
A
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans.
Peyman
G A
GA
Nikoleit
J
J
D000818:Animals; D016190:Carboplatin; D007267:Injections; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D012160:Retina / Q000187:drug effects*; D014822:Vitreous Body
D009944:Organoplatinum Compounds; C023359:iproplatin; D016190:Carboplatin