title: Prognostic role of preoperative nutritional and immunological assessment in the surgical patient.
abstract: The utilization of delayed hypersensitivity response (DHR) for the identification of high-risk patients with regard to postoperative septic complications is still discussed. The aim of this study was to clarify how much DHR may improve the prognostic capacity of nutritional assessment (NA). Nutritional and immunological evaluations were performed at admission on 405 patients undergoing elective general surgical procedures. Subjects with serum albumin less than or equal to 3.0 g/dl or total iron-binding capacity less than or equal to 220 micrograms/dl or weight loss greater than or equal to 10% with respect to usual body weight were classified as malnourished. DHR was assessed by performing skin tests with four recall antigens: PPD, candida, trichophyton, sk-sd. The incidence of postoperative complications resulted higher among the 187 malnourished patients (31.0%) than in the 218 well-nourished ones (14.2%) (p less than 0.001), and among the 213 anergic patients (29.6%) than in the 192 normal responders (13.5%) (p less than 0.001). To determine how much skin tests may improve the prognostic ability of NA, the relationship between DHR and postoperative complications was also studied in the malnourished and in the well-nourished patients, separately. In the malnourished group, the patients with an impairment of DHR had a higher incidence of postoperative infections than normal responders (p less than 0.05). In the well-nourished group, no significant differences were found between anergic patients and normal responders. In our study, DHR slightly improved the prognostic capacity of NA. Therefore, the first approach to identify the high-risk patients seems to be the unexpensive, quick and available determination of nutritional status.
authors.affiliation: Scientific Institute San Raffaele Hospital, Cattedra di Patologia Chirurgica, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Braga
authors.forename: P
authors.initials: P
authors.lastname: Baccari
authors.forename: S
authors.initials: S
authors.lastname: Scaccabarozzi
authors.forename: E
authors.initials: E
authors.lastname: Fiacco
authors.forename: G
authors.initials: G
authors.lastname: Radaelli
authors.forename: G
authors.initials: G
authors.lastname: Gallus
authors.forename: S
authors.initials: S
authors.lastname: DiPalo
authors.forename: V
authors.initials: V
authors.lastname: DiCarlo
authors.forename: M
authors.initials: M
authors.lastname: Cristallo
mesh_terms: D000946:Antigens, Fungal; D002176:Candida albicans; D003851:Deoxyribonucleases; D006801:Humans; D006968:Hypersensitivity, Delayed; D007428:Intradermal Tests; D009752:Nutritional Status; D011183:Postoperative Complications; D011300:Preoperative Care; D011379:Prognosis; D018805:Sepsis / Q000150:complications; D013300:Streptokinase
chemical_list: D000946:Antigens, Fungal; C007271:dermatophytin; D003851:Deoxyribonucleases; D013300:Streptokinase