TGTG, G clustering and other signals near non-mammalian vertebrate mRNA 3' termini: some implications.
Analysis of non-mammalian vertebrate DNA sequences in the 500 nucleotides preceding and 200 nucleotides following mRNA 3' termini yields some distinct signals. In addition to the well known AATAAA sequence, TGTG recurs very frequently further downstream. GGGG, TGGG, GGAG and GAGG are frequent in this region too. It is suggested that unlike the AATAAA mRNA cleavage/processing signal, the other signals noted above are signals on the DNA, i.e. they are signals for mRNA termination. An asymmetric distribution of some complementary sequences, e.g. TGTG vs. CACA, GGGG vs. CCCC, on the same DNA strand is noted as well. A few other signals are also observed.
Nussinov
R
R
Laboratory of Mathematical Biology, National Cancer Institute, Bethesda, MD 20205.
D000818:Animals; D001483:Base Sequence; D004247:DNA; D008969:Molecular Sequence Data; D012333:RNA, Messenger; D015398:Signal Transduction; D014714:Vertebrates
D012333:RNA, Messenger; D004247:DNA