Increase in permeability of Escherichia coli outer membrane by local anesthetics and penetration of antibiotics.
The MICs of several antibiotics (both hydrophobic and hydrophilic) which penetrate very poorly into intact Escherichia coli cells were found to be 2- to 10-fold decreased in the presence of low doses of various local anesthetics (procaine, dibucaine, tetracaine, chlorpromazine, and quinine). The concentrations of anesthetics necessary for this effect have no adverse effect on cell growth and are markedly lower than those concentrations used clinically.
Labedan
B
B
Institut de Microbiologie, Université Paris-Sud, Orsay, France.
D000617:Aminoglycosides; D000779:Anesthetics, Local / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004926:Escherichia coli / Q000378:metabolism*
D000617:Aminoglycosides; D000779:Anesthetics, Local; D000900:Anti-Bacterial Agents