HLA-A antigen incompatibility and HLA-B antigen compatibility associated with enhanced kidney allograft survival in blood-transfused patients.
The combined effect on 2-year primary kidney allograft survival of pretransplant blood transfusion, HLA-DR matching, HLA-A matching, HLA-B matching and other factors was analyzed in 116 azathioprine- and prednisolone-treated patients. The results show an hitherto unreported, statistically significant association between incompatibility for HLA-A antigens and enhanced graft survival in transfused recipients of transplants mismatched for HLA-DR (p = 0.005) and for HLA-B (p = 0.008). As expected, compatibility for HLA-B antigens was significantly associated with increased graft survival in transfused recipients of both HLA-DR compatible (p = 0.004) and HLA-DR incompatible (p = 0.01) grafts. If confirmed, the findings foreshadow new aspects of HLA matching in kidney transplantation and might explain the beneficial effect of blood transfusion on renal allograft survival.
Bućin
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Blood Bank and Tissue Typing Laboratory, University Hospital, Lund, Sweden.
D001803:Blood Transfusion; D006082:Graft Enhancement, Immunologic; D006085:Graft Survival / Q000276:immunology; D015234:HLA-A Antigens / Q000276:immunology*; D015235:HLA-B Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology; D006648:Histocompatibility; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D012189:Retrospective Studies
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens