Effects of a stable prostacyclin analog on experimental ischemic acute renal failure.
The effect of OP-41483, a stable prostacyclin (PGI2) analog, on ischemic acute renal failure (ARF) was investigated in dogs. Administration of OP-41483 for three days after ischemia significantly increased renal cortical blood flow (RCBF) when compared with dogs treated with the saline vehicle. In the OP-41483-treated group, serum creatinine levels remained relatively low during postoperative days 1-3 and mean survival time was prolonged. Injection of a silicone rubber vascular casting compound (Microfil) revealed increased numbers of visible renal cortical glomeruli and microvessels compared to the saline vehicle group. Histologic sections showed only very limited tubular necrosis, whereas sections of kidneys treated with saline showed extensive tubular necrosis. In conclusion, this stable prostacyclin analog provided a significant degree of protection for the kidneys from ischemic injury and may be useful in a clinical setting.
Tobimatsu
M
M
Department of Surgery 1, Kyushu University Faculty of Medicine, Fukuoka, Japan.
Ueda
Y
Y
Saito
S
S
Tsumagari
T
T
Konomi
K
K
D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D000818:Animals; D003404:Creatinine / Q000097:blood; D004285:Dogs; D011464:Epoprostenol / Q000627:therapeutic use* / Q000031:analogs & derivatives; D005260:Female; D007511:Ischemia / Q000150:complications; D007668:Kidney / Q000098:blood supply; D008297:Male; D012079:Renal Circulation / Q000187:drug effects*
D003404:Creatinine; D011464:Epoprostenol; C035847:ataprost