Cross-reactive antigens and HLA matching.
Anti-HLA-A2 and anti-B17 reactivity of 87 broadly reactive sera was studied by inhibition of monoclonal Ab binding. These Abs were detected as often in patients bearing Ags cross-reactive with A2 or B17 as in those not bearing such Ags. These results indicate that predictions of negative cross-matches based on Ag cross-reactivity or reactivity against public epitopes will not be accurate in a high proportion of cases.
Scornik
J C
JC
Department of Pathology, University of Florida College of Medicine, Gainesville 32610.
D000911:Antibodies, Monoclonal; D003429:Cross Reactions; D006680:HLA Antigens / Q000276:immunology; D015234:HLA-A Antigens / Q000276:immunology; D015235:HLA-B Antigens / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*
D000911:Antibodies, Monoclonal; D006680:HLA Antigens; D015234:HLA-A Antigens; C037164:HLA-A28 antigen; D015235:HLA-B Antigens; C037449:HLA-B17 antigen