title: [Genetic aspects of systematic mineralization disorders].
abstract: Forced selection for high daily gains and meatiness induced biological maladaptations of genetical-hormonal origin. They manifest themselves not only by well-known myopathies and predispositions to stress, but also in the so-called leg weakness of pigs, in dyschondroplasias of broilers; similar "correlated" effects are observed even in dogs and laboratory animals. As far as bones, cartilages and joints are concerned by these deficiencies in mineralization and synthesis of fibrous structures, the terms "osteochondrosis" or "osteochondropathies" were introduced recently. Manifestations and severeness of this phenomenon--induced by antagonistic selection criteria--species not always directly comparable from species to species or even from breed to breed within species. This variability can be interpreted as an indication for the compound effects of heredity and environment. Even in pure breeds like German landrace and Piétrain and even under identical rearing and fattening conditions a significant individuality was found with respect to utilization of minerals; this is documented by different biomechanical strength and mineralization of bones and cartilaginous structures in these animals and by estimates of heritability for these traits, which range slightly higher than those estimated for "leg weakness". Selective measures, therefore, against the antagonisms mentioned could be feasible. On the other hand these investigations revealed that at least in some contingents of domestic animals a biological borderline was trespassed when selecting rigorously for a few economically important traits.
authors.affiliation: Institut für Tierzucht der Tierärztlichen Hochschule Hannover.
authors.forename: W
authors.initials: W
authors.lastname: Wegner
mesh_terms: D000818:Animals; D001851:Bone Diseases, Metabolic / Q000235:genetics / Q000662:veterinary*; D001947:Breeding; D008903:Minerals / Q000378:metabolism*; D010007:Osteochondritis / Q000235:genetics / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000235:genetics*
chemical_list: D008903:Minerals
vernacular_title: Genetische Aspekte systemischer Mineralisationsstörungen.