title: Gene probe analysis demonstrates independent clonal evolution of co-existent chronic myeloid and chronic lymphocytic leukaemia.
abstract: We describe a case of Philadelphia-positive chronic myeloid leukaemia occurring simultaneously with B-cell chronic lymphocytic leukaemia in a 69-yr-old male. Gene probe analysis of DNA from both peripheral blood and bone marrow provided evidence for the independent evolution of 2 clones in this case, with a predominant population showing immunoglobulin heavy chain gene rearrangement and a smaller population showing a rearrangement within the breakpoint cluster region of chromosome 22.
authors.affiliation: Department of Haematology, Royal Free Hospital, Hampstead, London, U.K.
authors.forename: P J
authors.initials: PJ
authors.lastname: Browett
authors.forename: J
authors.initials: J
authors.lastname: Pattinson
authors.forename: J
authors.initials: J
authors.lastname: Pinkney
authors.forename: A V
authors.initials: AV
authors.lastname: Hoffbrand
authors.forename: J D
authors.initials: JD
authors.lastname: Norton
mesh_terms: D000368:Aged; D002892:Chromosomes, Human, Pair 22; D005796:Genes; D005821:Genetic Techniques; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000473:pathology; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D008297:Male; D010677:Philadelphia Chromosome; D011995:Recombination, Genetic; D014178:Translocation, Genetic
chemical_list: D007136:Immunoglobulins