Disturbance of peripheral microcirculation by LHRH-agonists. II.
It could be demonstrated with the aid of a cheek pouch model of the hamster that the LHRH-agonist lutrelin (Wyeth, WY 40972) caused disturbances of microcirculation within minutes, for example constriction of the arterioles and venules, reduction in capillary density and increased permeability, effects which were not reversible within the observation period (1 h) and could not be antagonized by the cyclooxygenase inhibitor indomethacin. Likewise, the lutrelin-induced accumulation of leucocytes in the capillaries of the testes of the rat could not be prevented within 6 hours after administration of indomethacin, whereas the harmful effect of lutrelin on the germinal epithelium could be antagonized by indomethacin within 24 hours. A biphasal course is assumed, characterised by an acute non-prostaglandin-dependent phase and a second prostaglandin-dependent phase, which causes the definitive damage to the testis of the rat.
Habenicht
U F
UF
Research Laboratories of Schering AG, Berlin (West) and Bergkamen/Federal Republic of Germany.
Mueller
B
B
D000818:Animals; D001160:Arterioles / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D006224:Cricetinae; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008647:Mesocricetus; D008833:Microcirculation / Q000187:drug effects*; D014699:Venules / Q000187:drug effects
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; C030741:lutrelin acetate; D007213:Indomethacin