Clinical applications of gonadotrophin-releasing hormone and its analogues.
The clinical applications of GnRH and its analogues are discussed. GnRH can be used diagnostically to assess the releasable pool of LH and the status of gonadotrophin secretion. Clinically it can be used to induce follicle growth and ovulation in patients with hypogonadotrophic amenorrhoea, especially when given in pulsatile form, and there are reports that it might also stimulate spermatogenesis in men with hypogonadotrophic hypogonadism. Analogues are proving valuable in the treatment of precocious puberty, but are not yet practical for contraception. They are more valuable in the treatment of endometriosis, hormone-dependent cancers, the polycystic ovary and for the induction of ovulation for in-vitro fertilization.
Bartfai
G
G
Department of Obstetrics and Gynecology, University Medical School of Szeged, Hungary.
D001943:Breast Neoplasms / Q000188:drug therapy; D003270:Contraceptive Agents; D004715:Endometriosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy; D008297:Male; D010062:Ovulation Induction / Q000379:methods; D010906:Pituitary Hormone-Releasing Hormones / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy; D011471:Prostatic Neoplasms / Q000188:drug therapy; D011629:Puberty, Precocious / Q000188:drug therapy; D013091:Spermatogenesis / Q000187:drug effects; D014594:Uterine Neoplasms / Q000188:drug therapy
D003270:Contraceptive Agents; D010906:Pituitary Hormone-Releasing Hormones