[Thrombosis prevention with heparin/dihydroergotamine versus heparin/Sintrom in Ender nailing of pertrochanteric fractures].
The effect of either (randomized) Heparin/Dihydroergotamine (HDHE) or heparin-acenocoumarin (Hep/S) on the incidence of deep-vein thrombosis in the legs was studied in 212 women of more than 60 years of age with hip fractures. All patients were screened with the 125-I-fibrinogen uptake test (FUT) confirmed by a bilateral ascending venogram upon positive FUT. This revealed good sensitivity and specificity (85/84%) for the FUT. Deep vein thrombosis developed in 37.6% of the HDHE group and in 59.1% of the Hep/S group which was significantly different (p less than 0.005). The calculated thrombosis risk was significantly diminished (by 38% - p less than 0.005) in the HDHE group. Therefore we conclude that in traumatology Heparin/Dihydroergotamine seems to be the prophylaxis of choice.
Schlag
G
G
Ludwig-Boltzmann-Institut für Experimentelle Traumatologie, Wien.
Gaudernak
T
T
Pelinka
H
H
Redl
H
H
Kuderna
H
H
Poigenfürst
J
J
D000074:Acenocoumarol / Q000008:administration & dosage; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use*; D001858:Bone Nails; D004087:Dihydroergotamine / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006493:Heparin / Q000008:administration & dosage; D006620:Hip Fractures / Q000150:complications / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control*
D000925:Anticoagulants; D004087:Dihydroergotamine; D006493:Heparin; D000074:Acenocoumarol
Thromboseprophylaxe mit Heparin/Dihydroergotamin versus Heparin/Sintrom in Ender-genagelten pertrochanteren Frakturen.