The central role of progesterone receptors and progestational agents in the management and treatment of breast cancer.
This article summarizes the role of progesterone receptors (PgRs) as markers of hormone-dependent breast cancers and the use of progestational agents in breast cancer treatment. We discuss the structure of PgRs, their purification, the production of anti-PgR monoclonal antibodies, and the use of these antibodies for clinical assays.
Horwitz
K B
KB
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262.
D000911:Antibodies, Monoclonal; D001943:Breast Neoplasms / Q000032:analysis / Q000188:drug therapy; D005260:Female; D006801:Humans; D007118:Immunoassay; D011372:Progestins / Q000627:therapeutic use*; D011980:Receptors, Progesterone / Q000032:analysis*
D000911:Antibodies, Monoclonal; D011372:Progestins; D011980:Receptors, Progesterone