title: Effects of benzamidine derivatives on Ha-ras-1 mRNA accumulation in a Chinese hamster cell line transformed with the activated human T24 Ha-ras-1 oncogene.
abstract: Tetra benzamidine derivatives were found to inhibit proteinase activity, cell proliferation and accumulation of the Ha-ras-1 mRNA in the FHO6T1-1 Chinese Hamster cell line, transformed with the activated human T24-Ha-ras-1 oncogene. Di- and Tri-benzamidine derivatives were also found to be potent inhibitors of proliferation of FHO6T1-1 cells. These latter compounds could be proposed as useful substrates in the synthesis of drug-conjugated monoclonal antibodies or growth factors.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Universitá di Ferrara, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Nastruzzi
authors.forename: G
authors.initials: G
authors.lastname: Feriotto
authors.forename: D
authors.initials: D
authors.lastname: Spandidos
authors.forename: D
authors.initials: D
authors.lastname: Anzanel
authors.forename: R
authors.initials: R
authors.lastname: Ferroni
authors.forename: M
authors.initials: M
authors.lastname: Guarneri
authors.forename: R
authors.initials: R
authors.lastname: Barbieri
authors.forename: R
authors.initials: R
authors.lastname: Gambari
mesh_terms: D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D000911:Antibodies, Monoclonal; D001550:Benzamidines / Q000494:pharmacology*; D002460:Cell Line / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D011905:Genes, ras; D008855:Microscopy, Electron, Scanning; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D000578:Amidines; D000911:Antibodies, Monoclonal; D001550:Benzamidines; D012333:RNA, Messenger