title: Studies on the effect of superoxide dismutase (peroxinorm) on interleukin-1 activity.
abstract: The experiments were undertaken to determine the effect of Peroxinorm (superoxide dismutase) on the activity of interleukin-1 in vitro. The results give evidence that the influence of the drug examined on the activity/production of interleukin-1 can take different forms, relative to the concentration applied. At higher dilution (10(-7)) Peroxinorm suppressed the activity of Il-1, whereas at lower dilutions it was devoid of this effect. A conceivable mechanism of its activity in the treatment of the inflammations is also discussed.
authors.affiliation: Department of Experimental Therapy, Polish Academy of Sciences, Wrocław.
authors.forename: J
authors.initials: J
authors.lastname: Giełdanowski
authors.forename: B
authors.initials: B
authors.lastname: Orłowska
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D007375:Interleukin-1 / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D013482:Superoxide Dismutase / Q000494:pharmacology*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
chemical_list: D007375:Interleukin-1; D013482:Superoxide Dismutase