title: Cerebral germinomas and Klinefelter syndrome. A review.
abstract: Patients with Klinefelter syndrome appear to be predisposed to the development of extragonadal cerebral germinomas. A case of a pineal region germinoma in a boy 15 years of age with Klinefelter syndrome is documented in this article. In view of three other cases of cerebral germinomas associated with Klinefelter syndrome in the literature, a hypothesis for this predisposition is suggested.
authors.affiliation: Department of Pediatrics B, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Arens
authors.forename: D
authors.initials: D
authors.lastname: Marcus
authors.forename: S
authors.initials: S
authors.lastname: Engelberg
authors.forename: G
authors.initials: G
authors.lastname: Findler
authors.forename: R M
authors.initials: RM
authors.lastname: Goodman
authors.forename: J H
authors.initials: JH
authors.lastname: Passwell
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000209:etiology*; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications*; D008297:Male; D010871:Pinealoma / Q000209:etiology*