[Changes in the cell surface and cytoskeleton of A-431 cells under the action of epidermal growth factor].
Certain changes in human carcinoma A-431 are found by scanning electron microscopy. The early cell response to growth factor (after 10 minutes) involves a disappearance of microvilli, an appearance of ruffles and rounded cells, along with a decrease in cell attachment to the substrate. The cell surface changes correlate with the state of cytoskeleton elements: the material stained with iron hematoxylin is accumulated in ruffle formation sites. Retractional fibrils filled with the cytoskeleton material result from a decrease in the cell area.
Skopicheva
V I
VI
Skopichev
V G
VG
Teslenko
L V
LV
Nikol'skiĭ
N N
NN
D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D003599:Cytoskeleton / Q000187:drug effects* / Q000648:ultrastructure; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008871:Microvilli / Q000187:drug effects / Q000648:ultrastructure; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000648:ultrastructure
D004815:Epidermal Growth Factor
Izmeneniia kletochnoĭ poverkhnosti i tsitoskeleta kletok A-431 pri deĭstvii épidermal'nogo faktora rosta.