Single-dose versus traditional therapy for uncomplicated urinary tract infections.
In the treatment of uncomplicated urinary tract infection, single-dose therapy has appeared to be as efficacious as traditional 7-14 day therapy in women with cystitis without renal involvement. Current localizing techniques to differentiate between lower- and upper-tract disease are inadequate for routine clinical practice. As a result we have proposed that failure of cure with single-dose treatment may be the most specific test available to diagnose renal infection. Most of the published data on single-dose therapy involves treatment with either amoxicillin or trimethoprim-sulfamethoxazole. Single-dose therapy offers advantages over traditional therapy, including improved compliance, reduced adverse effects, and decreased cost. Appropriate patient selection is critical if the outcome of single-dose therapy is to be effective.
Zhanel
G G
GG
Department of Pharmaceutical Services, Health Sciences Center, Winnipeg, Manitoba, Canada.
Ronald
A R
AR
D000658:Amoxicillin / Q000008:administration & dosage; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004338:Drug Combinations / Q000008:administration & dosage; D005260:Female; D006801:Humans; D013420:Sulfamethoxazole / Q000008:administration & dosage; D014295:Trimethoprim / Q000008:administration & dosage; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000892:Anti-Infective Agents, Urinary; D004338:Drug Combinations; D000658:Amoxicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole