Genotoxicity of selenite in diploid yeast.
Selenite, a chemical of industrial importance and also an antimutagenic/anticarcinogenic agent, was tested for mutagenic and recombinogenic effects in 2 diploid yeast strains, Saccharomyces cerevisiae BZ 34 and D7. Selenite induced gene conversion and toxicity in BZ 34 and a variety of genetic events, viz. back-mutation, gene conversion, mitotic crossing-over, aberrant colony formation and also toxicity in the D7 strain. In both strains, the genetic effects of selenite showed a peak and a decline during 5 h of treatment while its toxicity increased marginally during 1-5 h. In the BZ 34 strain, the presence of glutathione (GSH) during selenite treatment greatly enhanced the convertogenic and toxic effects of selenite.
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Division of Radiological Protection, Bhabha Atomic Research Centre, Trombay, Bombay, India.
Madhvanath
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D055598:Chemical Phenomena; D002621:Chemistry; D003434:Crossing Over, Genetic / Q000187:drug effects; D005785:Gene Conversion / Q000187:drug effects; D005978:Glutathione; D009152:Mutagenicity Tests; D010084:Oxidation-Reduction; D011995:Recombination, Genetic / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D020887:Selenious Acid; D012643:Selenium / Q000633:toxicity*
D020887:Selenious Acid; D005978:Glutathione; D012643:Selenium