N-acetyl-beta-glucosaminidase (NAG) and alpha-glycosidase released by PAF in isolated perfused rat kidney.
The action of PAF is involved in various biological activities, including alterations at the renal level. Previous experiments of ours have shown that PAF is capable of inducing histamine release at this level, and causing histological damage in the isolated perfused rat kidney. On the basis of these observations, the same experimental model was used to evaluate the release of enzymes such as NAG and alpha-glycosidase, which are precocious markers of renal damage. Results show that both NAG and alpha-glycosidase increase after PAF administration.
Giovannini
L
L
Institute of Pharmacology, Medical School, University of Pisa, Italy.
Mian
M
M
Alessandrì
M G
MG
Galligani
P
P
Bertelli
A A
AA
D000118:Acetylglucosaminidase / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006596:Hexosaminidases / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D010972:Platelet Activating Factor / Q000008:administration & dosage / Q000502:physiology* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D000520:alpha-Glucosidases / Q000378:metabolism*
D010972:Platelet Activating Factor; D006596:Hexosaminidases; D000520:alpha-Glucosidases; D000118:Acetylglucosaminidase