Intravitreal liposome-encapsulated drugs: a preliminary human report.
Intravitreal liposome-encapsulated antibiotics and antiviral drugs were used in patients with acute toxoplasmosis retinochoroiditis, presumed propionibacterium acne endophthalmitis after cataract surgery, and presumed cytomegalovirus retinitis associated with AIDS. A single intravitreal dose was effective in the treatment of all the conditions. Intravitreal liposomes may prove to be an advantageous drug delivery system for the treatment of chronic intraocular inflammatory disorders.
Peyman
G A
GA
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans.
Charles
H C
HC
Liu
K R
KR
Khoobehi
B
B
Niesman
M
M
D000212:Acyclovir / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000328:Adult; D002981:Clindamycin / Q000008:administration & dosage*; D004337:Drug Carriers; D004338:Drug Combinations; D005128:Eye Diseases / Q000188:drug therapy*; D015774:Ganciclovir; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D014822:Vitreous Body
D004337:Drug Carriers; D004338:Drug Combinations; D005839:Gentamicins; D008081:Liposomes; D002981:Clindamycin; D015774:Ganciclovir; D000212:Acyclovir