Effect of lung airway branching pattern and gas composition on particle deposition. I. Background and literature review.
This paper reviews (1) the influence of airflow and particle motion on particle deposition within human lung airways, (2) the effects of carrier gas properties on mass transport in lung airways, and (3) the differences in particle deposition patterns and efficiencies between humans and experimental animals. The primary purpose of this review of general principles and available literature is to identify critical factors affecting the dosimetry of inhaled toxicants. Special attention is paid to studies utilizing gases of varying composition, which illuminate the role of flow profiles and turbulence in gas and particle penetration, and to studies of the effects of interspecies differences in airway branching patterns on particle deposition patterns within the airways.
Lippmann
M
M
Institute of Environmental Medicine, New York University Medical Center, NY 10016.
Esch
J L
JL
D000818:Animals; D001693:Biological Transport, Active; D055592:Biophysical Phenomena; D001703:Biophysics; D005740:Gases / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000033:anatomy & histology / Q000502:physiology*; D011659:Pulmonary Gas Exchange; D012119:Respiration
D005740:Gases