title: Testing a mechanism of control in human cholesterol metabolism: relation of arginine and glycine to insulin and glucagon.
abstract: Eight men were given 2 casein meals, one with and one without a supplement of arginine and glycine, to measure the effect on plasma amino acids, insulin and glucagon. Supplementation resulted in increased levels of plasma glucagon, glycine and arginine, a tendency to decreased insulin and significantly lower insulin/glucagon ratio, tryptophan and tyrosine. The data suggest that insulin and glucagon, which control cholesterol metabolism, respond to dietary and postprandial plasma amino acid levels of arginine and glycine.
authors.affiliation: School of Public Health; Department of Pathology, Loma Linda University, CA 92350.
authors.forename: A
authors.initials: A
authors.lastname: Sanchez
authors.forename: R W
authors.initials: RW
authors.lastname: Hubbard
authors.forename: E
authors.initials: E
authors.lastname: Smit
authors.forename: G F
authors.initials: GF
authors.lastname: Hilton
mesh_terms: D000596:Amino Acids / Q000097:blood; D001120:Arginine / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism*; D004044:Dietary Proteins / Q000494:pharmacology*; D005934:Glucagon / Q000097:blood* / Q000502:physiology; D005998:Glycine / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000502:physiology; D008297:Male; D008875:Middle Aged
chemical_list: D000596:Amino Acids; D004044:Dietary Proteins; D007328:Insulin; D005934:Glucagon; D001120:Arginine; D002784:Cholesterol; D005998:Glycine