Application of a cellular test battery in the decision point approach to carcinogen identification.
The assessment of the potential carcinogenicity of a chemical requires a systematic approach taking into account various types of data. Important information on the DNA reactivity and other genetic effects of chemicals can be obtained from a battery of cellular tests. A battery is described which includes DNA repair in hepatocytes, mutagenesis in Salmonella typhimurium, mutagenesis, chromosome alterations, and transformation in mammalian cells. The interpretation of findings in this battery for the identification of potential carcinogenicity of chemicals is discussed.
Williams
G M
GM
American Health Foundation, Valhalla, NY 10595.
Weisburger
J H
JH
D000818:Animals; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D002875:Chromosomes / Q000187:drug effects; D004249:DNA Damage; D004260:DNA Repair; D066298:In Vitro Techniques; D009152:Mutagenicity Tests / Q000592:standards*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D002273:Carcinogens