The structural gene for the M1 subunit of ribonucleotide reductase maps to chromosome 11, band p15, in human and to chromosome 7 in mouse.
The genes for the M1 subunit of the enzyme ribonucleotide reductase have been mapped in the human and the murine species by use of two independently derived mouse cDNA clones. Southern blot analysis of rodent x human somatic cell hybrid DNAs confirmed the assignment of RRM1 to the short arm of human chromosome 11. In situ hybridization to human metaphase chromosomes revealed a peak of silver grains over the distal third of band 11p15, a region corresponding to subbands p15.4----p15.5. The mouse Rrml locus was assigned to chromosome 7, where it forms part of a conserved syntenic group of at least seven other genes assigned to human chromosome band 11p15.
Brissenden
J E
JE
Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510.
Caras
I
I
Thelander
L
L
Francke
U
U
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D006224:Cricetinae; D004247:DNA / Q000378:metabolism; D005796:Genes; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology; D046911:Macromolecular Substances; D051379:Mice; D009693:Nucleic Acid Hybridization; D012264:Ribonucleotide Reductases / Q000235:genetics*
D046911:Macromolecular Substances; D004247:DNA; D012264:Ribonucleotide Reductases