Comparative analysis of normal and malignant CD5+ B lymphocytes.
The T-cell related CD5 molecule is expressed by the major B cell population which forms primary follicles in fetal lymph nodes and spleen and circulates in cord blood but decreases to a numerically minor proportion (5-10% of all B cells) in adults [1, 3-5, 8, 9, 12, 14, 16]. The CD5 molecule is also expressed by the monoclonal B cells of B-chronic lymphocytic leukemia (B-CLL: reviewed in [5]). Even if there is no proof that CD5+ B cells are the target of the transforming events which lead to B-CLL, they are regarded as the normal counterpart of B-CLL. Therefore, the aim of the present work was the analysis of the phenotype, the cell cycle control and the cytoskeleton organization of normal CD5+ B lymphocytes in comparison with the data obtained on malignant CD5+ cells from B-CLL patients.
Riva
M
M
Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Italy.
Schena
M
M
Bergui
L
L
Tesio
L
L
Gaidano
G
G
Marchisio
P
P
Caligaris-Cappio
F
F
D000944:Antigens, Differentiation, B-Lymphocyte; D001402:B-Lymphocytes / Q000145:classification* / Q000166:cytology / Q000473:pathology; D002453:Cell Cycle; D003599:Cytoskeleton / Q000032:analysis / Q000473:pathology; D005312:Fetal Blood / Q000032:analysis / Q000166:cytology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000473:pathology; D010641:Phenotype
D000944:Antigens, Differentiation, B-Lymphocyte