DNA models for A, B, C and D conformations related to fiber X-ray, infrared and NMR measurements.
A conformational analysis of the A, B, C and D DNA forms was made in order to establish molecular models presenting a good agreement with experimental data obtained from fiber X-ray, infrared linear dichroism and 31P NMR. The proposed models have been refined and do present good stereochemistry and optimized H-bond distances between bases associated with the Watson-Crick pairing. The DNA conformations proposed are a left handed double helix for the C form and right handed helices for A, B and D. Relations to conformational transitions between these forms are discussed.
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Laboratoire de Biophysique Moléculaire, U.A. CNRS 497, Faculté des Sciences, Université de Nancy I, B.P.No 239, Vandoeuvre les Nancy, France.
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D004247:DNA / Q000648:ultrastructure*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
D004247:DNA