title: GnRH agonists and antagonists. Current clinical status.
abstract: Gonadotrophin-releasing hormone (GnRH) analogues offer a novel approach for the non-steroidal manipulation of the reproductive endocrine axis. GnRH agonists are now effectively employed in the management of precocious puberty, prostate and breast cancer, endometriosis, uterine leiomyoma, polycystic ovarian disease, and various other disorders. Unfortunately, contraceptive applications of GnRH agonists have been disappointing. The availability of slow release depot formulations of GnRH agonists, and the development of GnRH antagonists may further optimise and extend the clinical application of these compounds.
authors.affiliation: Department of Obstetrics and Gynecology, University of Bologna.
authors.forename: M
authors.initials: M
authors.lastname: Filicori
authors.forename: C
authors.initials: C
authors.lastname: Flamigni
mesh_terms: D006801:Humans; D010906:Pituitary Hormone-Releasing Hormones / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D010906:Pituitary Hormone-Releasing Hormones