title: Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin.
abstract: A cDNA encoding a human endothelium-derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary structure of the human preproendothelin has 212 amino acid residues and is highly homologous to porcine preproendothelin, and that human endothelin is identical with porcine endothelin.
authors.affiliation: Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd, Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Yanagisawa
authors.forename: S
authors.initials: S
authors.lastname: Ohkubo
authors.forename: C
authors.initials: C
authors.lastname: Kimura
authors.forename: T
authors.initials: T
authors.lastname: Kosaka
authors.forename: A
authors.initials: A
authors.lastname: Inoue
authors.forename: N
authors.initials: N
authors.lastname: Ishida
authors.forename: Y
authors.initials: Y
authors.lastname: Mitsui
authors.forename: H
authors.initials: H
authors.lastname: Onda
authors.forename: M
authors.initials: M
authors.lastname: Fujino
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D019332:Endothelin-1; D016232:Endothelins; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000235:genetics*; D010920:Placenta / Q000032:analysis; D011498:Protein Precursors / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D013552:Swine / Q000235:genetics
chemical_list: D019332:Endothelin-1; D016232:Endothelins; D010455:Peptides; D011498:Protein Precursors; D004247:DNA