Serology and genetics of human monocyte antigens (HMA system). Antibody, population and family studies.
This study was conducted for the purpose of detecting monocyte-specific alloantibodies by screening of sera which had been retroplacentally obtained, and with a view to delimitating their reactivity pattern from B and T lymphocytes. The data presented provide evidence for an unambiguous distinction of seven different monocyte antigens, MA-1 to MA-7. Segregation analyses of 14 informative families with 69 children revealed HLA-linked autosomal, codominant inheritance of these human monocyte antigen (HMA) via two gene loci (HMA-A and HMA-B) each of them with multiple allelism. The following gene frequencies were established: 0.1340 for HMA-A1; 0.0315 for HMA-A3; 0.0315 for HMA-A5; 0.0146 for HMA-A6; 0.0657 for HMA-B2; 0.0289 for HMA-B4, and 0.0614 for HMA-B7.
Rose
M
M
Institute of Forensic Medicine, School of Medicine Charité, Humboldt-Universität, Berlin, GDR.
D000483:Alleles; D000954:Antigens, Surface / Q000235:genetics*; D003602:Cytotoxicity, Immunologic; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006681:HLA-D Antigens / Q000235:genetics; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009000:Monocytes / Q000276:immunology*; D010375:Pedigree
D000954:Antigens, Surface; D006680:HLA Antigens; D006681:HLA-D Antigens; D007518:Isoantibodies