title: Resistive training can reduce coronary risk factors without altering VO2max or percent body fat.
abstract: Eleven healthy, untrained males (age = 44 +/- 1 yr; range = 40 to 55 yr) were studied to determine the effects of 16 wk of high-intensity resistive training on risk factors for coronary artery disease. Lipoprotein-lipid profiles, plasma glucose and insulin responses during an oral glucose tolerance test, and blood pressure at rest were determined before and after training. The training program resulted in a 13% increase in high-density lipoprotein-cholesterol (39 +/- 2 vs 44 +/- 3 mg.dl-1, P less than 0.05), a 43% increase in high-density lipoprotein-cholesterol (7 +/- 2 vs 10 +/- 2 mg.dl-1, P less than 0.05), a 5% reduction in low-density lipoprotein cholesterol (129 +/- 5 vs 122 +/- 5 mg.dl-1, P less than 0.05), and an 8% decrease in the total cholesterol/high-density lipoprotein-cholesterol ratio (5.1 +/- 0.3 vs 4.7 +/- 0.3, P less than 0.01), despite no changes in VO2max, body weight, or percent body fat. Glucose-stimulated plasma insulin concentrations during oral glucose tolerance testing were significantly lower, and supine diastolic blood pressure was reduced (P less than 0.05) as a result of the training program. No changes in any of these variables occurred in a sedentary control group. These findings indicate that resistive training can lower risk factors for coronary artery disease independent of changes in VO2max, body weight, or body composition.
authors.affiliation: Department of Medicine, Washington University, School of Medicine, St. Louis, MO 63110.
authors.forename: B F
authors.initials: BF
authors.lastname: Hurley
authors.forename: J M
authors.initials: JM
authors.lastname: Hagberg
authors.forename: A P
authors.initials: AP
authors.lastname: Goldberg
authors.forename: D R
authors.initials: DR
authors.lastname: Seals
authors.forename: A A
authors.initials: AA
authors.lastname: Ehsani
authors.forename: R E
authors.initials: RE
authors.lastname: Brennan
authors.forename: J O
authors.initials: JO
authors.lastname: Holloszy
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D001835:Body Weight; D003327:Coronary Disease / Q000517:prevention & control*; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D010806:Physical Education and Training / Q000379:methods*; D012307:Risk Factors; D014891:Weight Lifting
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D008074:Lipoproteins