[Ascorbic acid level and the indicators of cellular immunity in patients with hepatitis A during pathogenetic therapy].
Ascorbic acid content was assayed in plasma and neutrophils of peripheral blood in 260 patients with virus hepatitis A during acute period of the disease. The data obtained have evidenced C-hypovitaminosis in these patients, that was more pronounced in the winter-spring period, according to the disease severity 300 mg of ascorbic acid for 1.5 g of galascorbin/day have proved to be the most optimal dose for vitamin C deficiency elimination. A significant decrease in T-lymphocyte level and an increase in 0-cell content were recorded in the acute period of virus hepatitis A. Ascorbic acid drugs promoted more rapid recovery of T-lymphocyte content in the peripheral blood that has confirmed the necessity of vitamin C administration in combined pathogenetic therapy of patients with virus hepatitis A.
Vasil'ev
V S
VS
Komar
V I
VI
D001205:Ascorbic Acid / Q000097:blood* / Q000627:therapeutic use; D001206:Ascorbic Acid Deficiency / Q000188:drug therapy / Q000276:immunology; D006506:Hepatitis A / Q000097:blood*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D009504:Neutrophils / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*
D001205:Ascorbic Acid
Obespechennost' askorbinovoĭ kislotoĭ i pokazateli kletochnogo immuniteta u bol'nykh virusnym gepatitom A v protsesse patogeneticheskoi terapii.