Studies on the effect of superoxide dismutase (peroxinorm) on interleukin-1 activity.
The experiments were undertaken to determine the effect of Peroxinorm (superoxide dismutase) on the activity of interleukin-1 in vitro. The results give evidence that the influence of the drug examined on the activity/production of interleukin-1 can take different forms, relative to the concentration applied. At higher dilution (10(-7)) Peroxinorm suppressed the activity of Il-1, whereas at lower dilutions it was devoid of this effect. A conceivable mechanism of its activity in the treatment of the inflammations is also discussed.
Giełdanowski
J
J
Department of Experimental Therapy, Polish Academy of Sciences, Wrocław.
Orłowska
B
B
D000818:Animals; D002478:Cells, Cultured; D007375:Interleukin-1 / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D013482:Superoxide Dismutase / Q000494:pharmacology*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D007375:Interleukin-1; D013482:Superoxide Dismutase