title: Carbon monoxide poisoning at a lowered myocardial adaptation capacity: animal ECG models.
abstract: Two animal models for testing foreign substances for the hypoxic type of cardiotoxicity proved to be valid and reproducible: i.e. decreased reserve capacity of the heart in rats recovered from the calciferol cardiopathy and increased heart work provoked by isoproterenol (5 mg/kg i.p.). In both cases obvious hypoxic ECG changes appeared at lower levels of exposure to carbon monoxide (500 ppm, 572 mg.m-3) and carboxyhemoglobin (18%), when compared with nonpretreated animals. The models have shown, that injured or overloaded heart displays a substantially increased sensitivity to CO poisoning.
authors.affiliation: Institute of Hygiene and Epidemiology, Centre of Industrial Medicine and Occupational Diseases, Praha.
authors.forename: H
authors.initials: H
authors.lastname: Mikisková
authors.forename: E
authors.initials: E
authors.lastname: Frantík
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002249:Carbon Monoxide Poisoning / Q000503:physiopathology*; D009202:Cardiomyopathies / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D002784:Cholesterol; D004562:Electrocardiography; D004872:Ergocalciferols; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D000860:Hypoxia / Q000139:chemically induced / Q000503:physiopathology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D051381:Rats
chemical_list: D004872:Ergocalciferols; D002784:Cholesterol; D007545:Isoproterenol