title: In vitro activities of eight antibiotics against methicillin-resistant S. aureus and S. epidermidis strains isolated in Korea.
abstract: Staphylococcus aureus and Staphylococcus epidermidis strains isolated at eight large medical centers in Korea were examined for methicillin resistance and resistance to eight other antibiotics; cefazolin, cefamandole, cefuroxime, cefoxitin, cefotaxime, moxalactam, penicillin G and vancomycin. Methicillin resistance was found in 296 of 1225 strains (24.2%) of S. aureus and 126 of 348 strains (36.2%) of S. epidermidis. Methicillinresistant strains were isolated from all sources with the frequency of isolation ranging from 11% to 60%. From pleural effusion, throat swab and blood, methicillin-resistant strains of S. aureus were more frequently isolated with statistical significance (Chi-squared test, 95% confidence). Almost all of Methicillin-resistant S. aureus (MRSA) and S. epidermidis (MRSE) strains were multiply resistant to one or more tested eight antibiotics. However only 7(2.4%) of 296 MRSA strains and 2(1.6%) of 126 MRSE strains were resistant to vancomycin. Vancomycin was the most effective antibiotic against staphylococcal isolates as well as MRSA and MRSE.
authors.affiliation: College of Medicine, Seoul National Univ.
authors.forename: W H
authors.initials: WH
authors.lastname: Chang
authors.forename: M S
authors.initials: MS
authors.lastname: Choi
authors.forename: H Y
authors.initials: HY
authors.lastname: Chung
authors.forename: W J
authors.initials: WJ
authors.lastname: Seo
authors.forename: T Y
authors.initials: TY
authors.lastname: Choi
authors.forename: Y S
authors.initials: YS
authors.lastname: Chong
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
authors.forename: S S
authors.initials: SS
authors.lastname: Chung
authors.forename: S H
authors.initials: SH
authors.lastname: Hong
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006801:Humans; D007723:Korea; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents