title: [Histological observations on muscle tissue reactions to porous hydroxyapatite sintered bodies in rats].
abstract: Blocks of porous hydroxyapatite (dimensions, 2 X 3 X 4 mm3; sintering temperature, 1,150 degrees C; macroporosity, 48%; pore diameter, 50-300 microns) were implanted into the intervening space between the tibial periosteum and the tibialis anterior muscle in 36 male Wistar rats at the age of 5 months. Specimens from the lower leg were obtained 1, 2, 3, 5, 8 and 12 weeks after implantation. The implants were found to adhere firmly to the tibialis anterior in the 5 and 12 week-specimens. No inflammatory reactions were seen around the implants and a layer of fibrous tissue was observed between the implanted apatite block and the muscle in all specimens. The fibrous tissue penetrated deeply into pores of the apatite block. The resistance to pulling of the interface (3 X 4 mm2) between porous hydroxyapatite and the tibialis anterior muscle was measured using a universal testing machine. The mean of the resistance to pulling was 24.7 +/- 5.1 gf/mm2 in 4 specimens of 12 weeks implantation.
authors.affiliation: Department of Orthopedic Surgery, Yokohama City University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Negami
mesh_terms: D000818:Animals; D005549:Foreign-Body Reaction / Q000473:pathology*; D006614:Hindlimb; D006882:Hydroxyapatites / Q000009:adverse effects*; D008297:Male; D009132:Muscles / Q000473:pathology*; D019736:Prostheses and Implants / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006882:Hydroxyapatites