title: [Monoclonal antibodies against the alpha-chain of human lymphocyte function-associated antigen-1].
abstract: The goal of the investigation was to further characterize ICO-II monoclonal antibodies. ICO-II have been shown to block NK activity of mononuclear cells from the blood of healthy donors against K-562 and Molt-4 target cells, cytotoxic T lymphocytes induced in a 7-day mixed lymphocyte culture, the reaction of lymphocyte blast cell transformation to phytohemagglutinin and the formation of En-rosettes. The molecular weight of the antigen detected by ICO-II is 180 KD. ICO-II are shown to detect alpha-subunit of human lymphocyte function-associated antigen-I (LFA-I).
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Baryshnikov
authors.forename: I V
authors.initials: IV
authors.lastname: Dubinkin
authors.forename: E V
authors.initials: EV
authors.lastname: Savel'eva
authors.forename: T K
authors.initials: TK
authors.lastname: Veskova
authors.forename: N N
authors.initials: NN
authors.lastname: Tupitsyn
mesh_terms: D000208:Acute Disease; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D006801:Humans; D007938:Leukemia / Q000276:immunology; D016169:Lymphocyte Function-Associated Antigen-1; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D016169:Lymphocyte Function-Associated Antigen-1
vernacular_title: Monoklonal'nye antitela protiv al'fa-tsepi chelovecheskogo limfotsitarnogo funktsional'no-assotsiirovannogo antigena-(LFA-1).