title: Heterotopic prosthetic ventricles as a bridge to cardiac transplantation. A multicenter study in 29 patients.
abstract: Heterotopic prosthetic ventricles were used to support the circulation in 29 candidates for heart transplantation who were expected to die before procurement of a donor heart. Twenty-one of these patients (average age, 36 years) underwent successful transplantation after 8 hours to 31 days of circulatory support. The other eight patients died because their condition could not be stabilized for transplantation, despite restoration of blood flow. Fourteen patients received biventricular support; 15 received only left ventricular support, with pharmacologic assistance of right heart function. Before transplantation, blood flow from the left prosthetic ventricle averaged 2.8 +/- 0.4 liters per minute per square meter of body-surface area, and from the right prosthesis 2.4 +/- 0.4 liters, as compared with an average flow of 1.6 +/- 0.5 liters per minute per square meter before implantation. Of the 21 patients who received heart transplants, 20 were discharged from the hospital after a median of 31 days. Nineteen patients were alive at 7 to 39 months, and 11 of the first 12 were alive at one year. We conclude that heterotopic placement of prosthetic ventricles as a bridge to transplantation provides an effective method of temporarily supporting cardiac function in critically ill patients without removing the natural heart. The early survival rate after transplantation is similar to that with elective cardiac transplantation.
authors.affiliation: Department of Cardiovascular Surgery, Pacific Presbyterian Medical Center, San Francisco, CA 94120.
authors.forename: D J
authors.initials: DJ
authors.lastname: Farrar
authors.forename: J D
authors.initials: JD
authors.lastname: Hill
authors.forename: L A
authors.initials: LA
authors.lastname: Gray
authors.forename: D G
authors.initials: DG
authors.lastname: Pennington
authors.forename: L R
authors.initials: LR
authors.lastname: McBride
authors.forename: W S
authors.initials: WS
authors.lastname: Pierce
authors.forename: W E
authors.initials: WE
authors.lastname: Pae
authors.forename: B
authors.initials: B
authors.lastname: Glenville
authors.forename: D
authors.initials: D
authors.lastname: Ross
authors.forename: T A
authors.initials: TA
authors.lastname: Galbraith
mesh_terms: D000293:Adolescent; D000328:Adult; D001243:Assisted Circulation / Q000009:adverse effects; D002986:Clinical Trials as Topic; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation; D006353:Heart-Assist Devices / Q000009:adverse effects; D006439:Hemodynamics; D006801:Humans; D007423:Intra-Aortic Balloon Pumping; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design; D013997:Time Factors