Haemostatic aspects of renal transplantation.
Platelet function and protein C activity and antigen level was studied in 31 renal transplant recipients and 10 healthy controls. The patients were divided into three groups: (I) cyclosporin treated, (II) azathioprine treated, and (III) azathioprine treated patients with chronic rejection. The platelet function in the renal transplant patients was normal and there was no difference between groups I and II. The specific activity of protein C was decreased in patients after renal transplantation and decreasing protein C activity and progressive renal failure was found to be positively correlated in the azathioprine treated groups.
Sørensen
P J
PJ
Department of Nephrology, Aalborg Hospital, Denmark.
Schmidt
E B
EB
Knudsen
F
F
Nielsen
A H
AH
Kristensen
S D
SD
Dyerberg
J
J
Kornerup
H J
HJ
D000328:Adult; D001379:Azathioprine / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects*; D003404:Creatinine / Q000378:metabolism; D003524:Cyclosporins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011486:Protein C / Q000378:metabolism*
D003524:Cyclosporins; D011486:Protein C; D003404:Creatinine; D001379:Azathioprine