[Implantation of embryonic pancreas into the anterior chamber of healthy and diabetic rats].
The possibility of pancreatic-islet embryonic implantation into the frontal chamber of the eye in Wistar rats has been demonstrated. The implantation was followed by the induction of alloxan diabetes. Clinical diabetic compensation has been shown in a number of experimental animals (maximum time of experiments--45 days). The formation of islet-like structures in the frontal chamber of the eye was confirmed microscopically. The structures contained B cells in their cytoplasm. Cellular differentiation leading to the appearance of functionally active endocrine cells has been noted in the implants.
Zharkov
V P
VP
Iarygin
V N
VN
Gol'tsman
L L
LL
D000818:Animals; D000867:Anterior Chamber / Q000166:cytology; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000473:pathology / Q000628:therapy*; D004622:Embryo, Mammalian; D005260:Female; D008297:Male; D008722:Methods; D010179:Pancreas / Q000166:cytology; D016035:Pancreas Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014184:Transplantation, Homologous
D001786:Blood Glucose
Implantatsiia émbrional'noĭ podzheludochnoĭ zhelezy v peredniuiu kameru glaza zdorovym i diabeticheskim krysam.