title: Implications from the occurrence of Reiter's syndrome and related disorders in association with advanced HIV infection.
abstract: Information bearing on the prevalence and character of Reiter's syndrome and allied disorders as they occur in a setting of HIV infection was reviewed. Based on the frequency of infections by organisms capable of inducing reactive arthritis and the presence of HLA-B27 in 71% of the individuals, it was concluded that the disorder strongly resembled Reiter's syndrome occurring in the non-HIV infected group. Preliminary evidence suggested an enhanced penetrance of susceptibility among HLA-B27 individuals. In view of the preservation of CD8 lineage T cells and functional loss of CD4 lineage T cells in HIV-infected patients, it was suggested that a specific immune recognition event is at the center of the pathogenesis of this syndrome which involves preservation of an unknown antigen in the context of HLA-B27 to CD8 lineage suppressor/cytotoxic T cells.
authors.affiliation: Hospital for Joint Diseases, Department of Rheumatology, New York, NY 10003.
authors.forename: R
authors.initials: R
authors.lastname: Winchester
authors.forename: L
authors.initials: L
authors.lastname: Brancato
authors.forename: S
authors.initials: S
authors.lastname: Itescu
authors.forename: M L
authors.initials: ML
authors.lastname: Skovron
authors.forename: G
authors.initials: G
authors.lastname: Solomon
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology*; D001168:Arthritis / Q000276:immunology; D016918:Arthritis, Reactive / Q000150:complications / Q000276:immunology*; D004198:Disease Susceptibility; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D006801:Humans; D011565:Psoriasis / Q000276:immunology
chemical_list: D015235:HLA-B Antigens; D015796:HLA-B27 Antigen