Cutaneous angiomas in POEMS syndrome. An ultrastructural and immunohistochemical study.
Cutaneous manifestations of POEMS (polyneuropathy, organomegaly, endocrinopathies, M-protein, and skin changes) syndrome in a 51-year-old white man included two types of hemangiomas, ie, cherry-type and subcutaneous hemangiomas. By light microscopy and immunohistochemistry, both types of tumors showed features of capillary hemangiomas. By electron microscopy, a peculiar finding of subcutaneous hemangiomas was the presence of slender abluminal processes of endothelial cells that were frequently anastomosing to form electron-lucent blebs. Although the precise etiopathogenesis of the vascular proliferations remains speculative, these lesions merit study since they constitute an easily recognizable marker of POEMS syndrome.
Kanitakis
J
J
Department of Dermatology, Hôpital Edouard Herriot, Lyon, France.
Roger
H
H
Soubrier
M
M
Dubost
J J
JJ
Chouvet
B
B
Souteyrand
P
P
D004967:Estrogens / Q000097:blood; D005455:Fluorescent Antibody Technique; D006391:Hemangioma / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010265:Paraproteinemias / Q000473:pathology*; D012878:Skin Neoplasms / Q000648:ultrastructure*; D013577:Syndrome
D004967:Estrogens