[Dynamics of clinico-immunologic indices in patients with endocrine ophthalmopathy undergoing treatment with the preparation parlodel].
The immune status and the time course of ophthalmological indices were studied in 54 patients with endocrine ophthalmopathy during bromocriptine therapy. Twelve weeks after the onset of therapy indices of the immune status returned to normal in parallel with the regression of ophthalmological symptoms. In the control group (20 patients with endocrine ophthalmopathy who did not receive bromocriptine) significant improvement of the clinicoimmunological status was unnoticed. An increase in the number of T-lymphocytes, a decrease in the number of B-lymphocytes, an increase in the level of IgG, and a decrease in the levels of IgA and IgM were observed during bromocriptine therapy. The time of the immunity indices could serve as a criterion of bromocriptine therapeutic efficacy in patients with endocrine ophthalmopathy.
Zinkevich
I V
IV
Kazeev
K N
KN
Poliak
A I
AI
Zhuravlev
V S
VS
D000328:Adult; D000368:Aged; D000917:Antibody Formation / Q000187:drug effects; D001402:B-Lymphocytes / Q000276:immunology; D001971:Bromocriptine / Q000627:therapeutic use*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D005128:Eye Diseases / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007136:Immunoglobulins / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology; D013959:Thyroid Diseases / Q000150:complications / Q000188:drug therapy / Q000276:immunology*
D007136:Immunoglobulins; D001971:Bromocriptine
Dinamika kliniko-immunologicheskikh pokazateleĭ u bol'nykh s éndokrinnoĭ oftal'mopatieĭ pri lechenii preparatom parlodel.