title: Amelioration of normothermic canine liver ischemia with prostacyclin.
abstract: A model of hepatic ischemia was developed in dogs using a pump-driven splanchnic-to-jugular vein bypass during crossclamping of the portal triad. An LD50 was established with three hours of ischemia. PGI2 given for one hour before the ischemic insult ameliorated the ischemic injury and increased survival.
authors.affiliation: Department of Surgery, University of Pittsburgh, PA.
authors.forename: S
authors.initials: S
authors.lastname: Todo
authors.forename: H
authors.initials: H
authors.lastname: Yokoi
authors.forename: L
authors.initials: L
authors.lastname: Podesta
authors.forename: P
authors.initials: P
authors.lastname: ChapChap
authors.forename: C
authors.initials: C
authors.lastname: Pan
authors.forename: K
authors.initials: K
authors.lastname: Okuda
authors.forename: Y
authors.initials: Y
authors.lastname: Kamiyama
authors.forename: J
authors.initials: J
authors.lastname: Demetris
authors.forename: L
authors.initials: L
authors.lastname: Makowka
authors.forename: S
authors.initials: S
authors.lastname: Iwatsuki
mesh_terms: D000818:Animals; D004285:Dogs; D011464:Epoprostenol / Q000494:pharmacology*; D007511:Ischemia / Q000503:physiopathology; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology
chemical_list: D011464:Epoprostenol