title: Immunohistochemical examination of Peyer's patches in autoimmune mice.
abstract: The distribution of T-cells and B-cells in Peyer's patches was examined in three autoimmune model mice, MRL/Mp-lpr/lpr, BXSB, NZBWF1/J mice and normal BALB/c mice, between one and ten months old. A multiple layering technique was used for immunohistochemical detection of lymphocyte surface antigens of T-cells (Thy1.2, Lyt1, Lyt2) and B-cells (surface IgM) and peanut agglutinin receptor for germinal center cells. The T-cell population of female MRL/Mp-lpr/lpr mice increased markedly with age, and the B-cell population of the male BXSB mouse tended to increase. However, little change was observed with age in the NZBWF1/J mice. The immunohistochemical properties of the Peyer's patches in the three autoimmune model mice were different.
authors.affiliation: Department of Pathology, Kyoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yoshioka
authors.forename: G
authors.initials: G
authors.lastname: Ohshio
authors.forename: F
authors.initials: F
authors.lastname: Furukawa
authors.forename: M
authors.initials: M
authors.lastname: Inada
authors.forename: S
authors.initials: S
authors.lastname: Miyata
authors.forename: Y
authors.initials: Y
authors.lastname: Hamashima
authors.forename: T
authors.initials: T
authors.lastname: Miyake
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010581:Peyer's Patches / Q000032:analysis* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001323:Autoantibodies