The extracellular matrix is a soluble and solid-phase agonist and receptor.
The components of the extracellular space have well-recognized structural functions. The role of the matrix as a conduit and/or repository for signals, however, has received much less attention. Because we know that cells require contact with the extracellular matrix for their normal function, that intact matrix and/or fragments of matrix in either soluble or solid phase can effect significant changes in cellular physiology, and that matrix components can be integral membrane proteins, we conclude that a major function of the matrix is as a soluble and solid-phase agonist and receptor.
Trelstad
R L
RL
Department of Pathology, Robert Wood Johnson Medical School, Piscataway, NJ 08854.
D002450:Cell Communication; D003094:Collagen / Q000502:physiology; D004820:Epidermolysis Bullosa / Q000209:etiology; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000502:physiology; D009024:Morphogenesis; D009844:Oligosaccharides / Q000378:metabolism; D010455:Peptides / Q000378:metabolism
D046911:Macromolecular Substances; D008565:Membrane Proteins; D009844:Oligosaccharides; D010455:Peptides; D003094:Collagen