title: Glucose, insulin and glucagon response to intravenous glucose load in patients on chronic hemodialysis.
abstract: We examined the theory that patients with chronic renal failure exhibit glucose intolerance that is not completely corrected by dialysis. I.v. glucose tolerance tests (IVGTT) were performed in 11 uremic patients who were on chronic intermittent hemodialysis therapy for a mean of 33 months, before and 24 h after dialysis. The glucose disappearance constants (K-glucose) were normal in all subjects and were not affected by dialysis. Insulin response was within normal limits, with minimal changes by dialysis. Serum glucagon was higher than normal. The early, middle and late insulin levels were the same as in the normal population. These results indicate that chronic hemodialysis therapy, together with continuous effective control of biochemical impairment, can achieve normal glucose tolerance in uremic patients.
authors.affiliation: Renal Unit, Western Galilee Regional Hospital, Nahariya, Israel.
authors.forename: S M
authors.initials: SM
authors.lastname: Shasha
authors.forename: D
authors.initials: D
authors.lastname: Nusem
authors.forename: Y
authors.initials: Y
authors.lastname: Kanter
authors.forename: F
authors.initials: F
authors.lastname: Weiner
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D002648:Child; D005260:Female; D005934:Glucagon / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014511:Uremia / Q000378:metabolism* / Q000628:therapy
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon