[In vitro evaluation of the antibiotic effect of imipenen on bacterial strains isolated mostly from compromised patients].
The antibacterial activity in vitro of Imipenem (N-formimidoyl-thienamycin) was studied on 237 recently-isolated nosocomial bacterial strains and compared with Aztreonam, Cefotaxime, Ceftazidime, Ceftriaxone, Piperacillin, Amikacin and Netilmicin through the determination of susceptibility by the Kirby-Bauer method. Taking into account that 65% bacterial strains, out of the examined ones, came from antibiotic high-pressure departments (45% from bone-marrow transplanted patients in the Hematological Department and 20% from Intensive Care Unit patients), the results obtained in vitro show an activity of Imipenem on Gram-negative bacteria as much as a 92.7% susceptibility and a 75.7% on Gram-positive bacteria; when compared with the activity of the other antibiotics, Imipenem shows a really excellent activity.
Bartolucci
M
M
Laboratorio di analisi cliniche e microbiologiche, Ospedale s. Salvatore, Pesaro.
Galluzzi
F
F
Sanchioni
G
G
Aureli
G
G
D004341:Drug Evaluation; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D007108:Immune Tolerance; D008826:Microbial Sensitivity Tests
D015378:Imipenem
Valutazione in vitro dell'attività antibiotica dell'imipenem su ceppi batterici isolati in prevalenza da pazienti compromessi.