Estimation of extracellular fluid volume from plasma clearance on technetium-99m DTPA by a single-injection, two-sample method.
A simple method is presented for estimating extracellular fluid volume from the plasma clearance of [99mTc])DTPA or [169Yb]DTPA. Two plasma samples are required, at 1 and 3 hr, following a single intravenous injection. (The same plasma samples can be used for measurement of glomerular filtration rate.) Using the complete plasma clearance curve as a reference (eight samples at 10 to 240 min), the error of the two-sample method in 40 patients was 1.5 I for [99mTc]DTPA, 2.1 I for [169Yb]DTPA (residual standard deviation).
Russell
C D
CD
Division of Nuclear Medicine, University of Alabama Hospital, Birmingham 35233.
Bischoff
P G
PG
Rowell
K L
KL
Lloyd
L K
LK
Dubovsky
E V
EV
D005110:Extracellular Space; D006801:Humans; D007677:Kidney Function Tests / Q000379:methods*; D009942:Organometallic Compounds / Q000378:metabolism; D004369:Pentetic Acid / Q000378:metabolism; D013667:Technetium / Q000378:metabolism; D016284:Technetium Tc 99m Pentetate
D009942:Organometallic Compounds; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate