title: Coumarin necrosis--a review of the literature.
abstract: Skin and soft tissue necrosis is a rare complication of anticoagulation therapy. Two patients who exhibited the spectrum of this disorder are described. The clinical features, etiology, pathophysiology, and treatment of coumarin skin necrosis are outlined, and the English-language literature is reviewed.
authors.affiliation: Department of Surgery, University of Texas Medical Branch, Galveston 77550.
authors.forename: M S
authors.initials: MS
authors.lastname: Cole
authors.forename: P K
authors.initials: PK
authors.lastname: Minifee
authors.forename: F J
authors.initials: FJ
authors.lastname: Wolma
mesh_terms: D000328:Adult; D000368:Aged; D003374:Coumarins / Q000009:adverse effects*; D004438:Ecchymosis / Q000139:chemically induced; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced*; D011693:Purpura / Q000139:chemically induced; D013924:Thrombophlebitis / Q000188:drug therapy; D014859:Warfarin / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D003374:Coumarins; D014859:Warfarin