Increases of neuropeptide Y-like immunoreactivity in plasma during insulin-induced hypoglycemia in man.
Neuropeptide Y-like immunoreactivity (NPY-LI) in plasma during insulin-induced hypoglycemia was measured in 4 healthy male volunteers. Plasma NPY-LI increased from 167 +/- 11 pg/ml to 247 +/- 25 pg/ml 30 min after the administration of insulin (0.1 U/kg body weight IV), reached the maximum (296 +/- 6 pg/ml) 45 min after the insulin, and then decreased. These results suggest that NPY is released into the systemic circulation during insulin-induced hypoglycemia in man.
Takahashi
K
K
Second Department of Internal Medicine, Tohoku University School of Medicine, Miyagi, Japan.
Mouri
T
T
Murakami
O
O
Itoi
K
K
Sone
M
M
Ohneda
M
M
Nozuki
M
M
Yoshinaga
K
K
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D006801:Humans; D007003:Hypoglycemia / Q000097:blood* / Q000139:chemically induced; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009478:Neuropeptide Y / Q000097:blood*; D012016:Reference Values
D001786:Blood Glucose; D007328:Insulin; D009478:Neuropeptide Y