title: Changes in densities and kinetics of delayed rectifier potassium channels during neuronal differentiation.
abstract: Single-channel K+ currents were recorded from young and mature spinal neurons cultured from Xenopus embryos to examine the bases of the developmental increases in density and in rate of activation of the macroscopic voltage-dependent delayed rectifier K+ current (IKv). K+ channels of three conductance classes (integral of 80, 30, and 15 pS) are present at both ages, but only the intermediate and small conductance classes are voltage-dependent and thus underlie IKv. The increase in the density of IKv is due to increases in the numbers of intermediate and small channels per cell, but not to changes in their open probabilities. The increase in rate of activation of IKv results from a change in the activation kinetics of the intermediate channel class alone.
authors.affiliation: Department of Biology, University of California, San Diego, La Jolla 92093.
authors.forename: G L
authors.initials: GL
authors.lastname: Harris
authors.forename: L P
authors.initials: LP
authors.lastname: Henderson
authors.forename: N C
authors.initials: NC
authors.lastname: Spitzer
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D004625:Embryo, Nonmammalian; D008564:Membrane Potentials; D015221:Potassium Channels / Q000502:physiology*; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*; D014982:Xenopus laevis
chemical_list: D015221:Potassium Channels