title: Anti-idiotypic humoral and cellular responses to antibody to hepatitis B surface antigen in hepatitis B viral infections.
abstract: In order to investigate regulatory significance of humoral and cellular responses to the idiotypic (Id) determinants on the antibody to hepatitis B surface antigen (anti-HBs), they were studied in acute hepatitis B and in chronic HBV infection. The results were compared with humoral and cellular responses of the same patients to hepatitis B surface antigen (HBsAg). In acute hepatitis B, the responses to HBsAg, were delayed until 3-4 weeks after the onset of clinical symptoms. However, the leucocyte migration inhibition (LMI) and the lymphocyte transformation (LTT) responses to affinity purified anti-HBs were found to be evolved very early in the course of acute hepatitis B, though anti-Id antibodies were absent. The majority of chronic HBV carriers showed a poor humoral and cellular response to HBsAg. Ten out of 38 chronic carriers showed anti-Id antibodies which recognized a major cross-reactive idiotype (CRI) on the anti-HBs molecule. Twenty-five out of 38 chronic carriers also showed LMI response to the Id determinants on the anti-HBs. LMI response induced by anti-HBs could be blocked by a specific Balb/c anti-Id antibody which also recognized the CRI. Thus, in both acute and chronic HBV infections, the anti-Id humoral and cellular responses correlated with poor humoral and cellular responses to HBsAg, indicating regulatory significance.
authors.affiliation: Department of Clinical Pathology, Haffikine Institute, Bombay, India.
authors.forename: S
authors.initials: S
authors.lastname: Rath
authors.forename: V
authors.initials: V
authors.lastname: Bal
authors.forename: B J
authors.initials: BJ
authors.lastname: Mohite
authors.forename: V
authors.initials: V
authors.lastname: Haridas
authors.forename: S R
authors.initials: SR
authors.lastname: Naik
authors.forename: S A
authors.initials: SA
authors.lastname: Kamat
authors.forename: A J
authors.initials: AJ
authors.lastname: Zuckerman
authors.forename: R S
authors.initials: RS
authors.lastname: Kamat
mesh_terms: D000208:Acute Disease; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis*; D002464:Cell Migration Inhibition; D002908:Chronic Disease; D005260:Female; D006509:Hepatitis B / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male
chemical_list: D000888:Antibodies, Anti-Idiotypic; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D007130:Immunoglobulin Idiotypes