title: Pharmacokinetic-pharmacodynamic modeling of CNS drug effects: an overview.
authors.affiliation: Center for Bio-Pharmaceutical Sciences, State University of Leiden, Sylvius Laboratories, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Dingemanse
authors.forename: M
authors.initials: M
authors.lastname: Danhof
authors.forename: D D
authors.initials: DD
authors.lastname: Breimer
mesh_terms: D001463:Barbiturates / Q000493:pharmacokinetics / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects*; D002491:Central Nervous System Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002492:Central Nervous System Depressants / Q000493:pharmacokinetics / Q000494:pharmacology*; D003975:Diazepam / Q000097:blood / Q000494:pharmacology; D004361:Drug Tolerance; D006801:Humans; D007700:Kinetics; D008954:Models, Biological
chemical_list: D001463:Barbiturates; D002491:Central Nervous System Agents; D002492:Central Nervous System Depressants; D003975:Diazepam