Comparison of the effects of nebulized terbutaline with intravenous enprofylline in patients with acute asthma.
We compared the bronchodilating effects of intravenously administered enprofylline (2 mg/kg) with nebulized terbutaline (10 mg) in patients presenting to hospital with acute asthma in a multicenter double-blind parallel study. One hundred twenty three patients were randomized into the study, and 69 of these fulfilled the inclusion criteria and a retrospective time to study entry criterion; 34 received enprofylline and 35 received terbutaline. There was no significant difference in maximum increase in forced expired volume in 1 second (FEV1) between the enprofylline group (0.24 +/- 0.33 L) and the terbutaline group (0.25 +/- 0.28 L) (p greater than 0.05), nor for the increase in FEV1 over the 1-hour study period. Tremor was reported more in the group receiving terbutaline, and nausea was reported more in the group receiving enprofylline. Two patients experienced hypotension and one patient had a vasovagal episode with enprofylline treatment. Both agents acted as bronchodilators with similar efficacy in patients with acute asthma in this study.
Ruffin
R
R
Bryant
D
D
Burdon
J
J
Marlin
G
G
Mitchell
C
C
O'Hehir
R
R
Wilson
J
J
Woolcock
A
A
Webb
S
S
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005541:Forced Expiratory Volume; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D011897:Random Allocation; D013726:Terbutaline / Q000008:administration & dosage* / Q000009:adverse effects; D014970:Xanthines / Q000008:administration & dosage* / Q000009:adverse effects
D001993:Bronchodilator Agents; D014970:Xanthines; C034347:enprofylline; D013726:Terbutaline