Hyperfractionated total body irradiation for T-depleted HLA identical bone marrow transplants.
Twenty patients suffering from malignant hemopathies (mean age 31.7 years) were given hyperfractionated total body irradiation (TBI) (120 cGy/3 fractions per day: total dose = 1440 cGy/4 days) as conditioning for T-depleted HLA identical allogeneic bone marrow transplantation. At an average of 12 months (range of 4.5-22 months) follow-up there were two cases of early death and two cases (11%) of rejection. There were no cases of acute or chronic graft versus host disease (GVHD) nor cases of interstitial pneumonitis. The average time for durable engraftment was 22 days. Disease-free survival at 12 months was 65%. To improve the results and further reduce the percent of rejection, the authors propose intensifying the immunosuppressive conditioning by increasing the cyclophosphamide dose and that of TBI so that a total dose of 1560 cGy is reached.
Latini
P
P
Radiation Oncology Service, University and Hospital, Policlinico, Perugia, Italy.
Checcaglini
F
F
Maranzano
E
E
Aristei
C
C
Panizza
B M
BM
Gobbi
G
G
Raymondi
C
C
Aversa
F
F
Martelli
M F
MF
D000328:Adult; D001853:Bone Marrow / Q000276:immunology; D016026:Bone Marrow Transplantation; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000532:radiotherapy; D007958:Leukocyte Count; D008212:Lymphocyte Depletion; D008228:Lymphoma, Non-Hodgkin / Q000532:radiotherapy; D009101:Multiple Myeloma / Q000532:radiotherapy; D013601:T-Lymphocytes / Q000276:immunology; D014916:Whole-Body Irradiation
D006680:HLA Antigens