Postoperative analgesia by continuous extradural infusion of bupivacaine and diamorphine.
Three solutions administered by continuous extradural infusion for postoperative analgesia were compared in a randomized, double-blind manner. All patients underwent major abdominal gynaecological surgery and received 0.125% bupivacaine in 0.9% saline, diamorphine in 0.9% saline (0.5 mg in 15 ml) or diamorphine mixed with 0.125% bupivacaine (0.5 mg in 15 ml), at a rate of 15 ml h-1. The bupivacaine-diamorphine mixture provided significantly superior analgesia compared with either bupivacaine or diamorphine alone. No major side effects were encountered.
Lee
A
A
Department of Anaesthetics, Royal Infirmary, Edinburgh.
Simpson
D
D
Whitfield
A
A
Scott
D B
DB
D000005:Abdomen / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D000767:Anesthesia, Epidural; D002045:Bupivacaine / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D003932:Heroin / Q000008:administration & dosage*; D006801:Humans; D007263:Infusions, Parenteral; D008875:Middle Aged; D010149:Postoperative Pain / Q000628:therapy*; D011897:Random Allocation; D013997:Time Factors
D003932:Heroin; D002045:Bupivacaine