Concomitant K- and N-ras gene point mutations in clonal murine lymphoma.
We have surveyed a panel of induced murine lymphomas for c-ras gene mutations. The K-ras gene seems to be preferentially activated in our system, and there are at least two examples of concomitant K- and N-ras gene mutations in the same tumor. This indicates that in some cases additional ras mutations may contribute to tumorigenesis and is evidence for a role of ras activation in tumor progression.
Diamond
L E
LE
Department of Pathology, New York University Medical Center, New York 10016.
Guerrero
I
I
Pellicer
A
A
D000483:Alleles; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D008223:Lymphoma / Q000139:chemically induced / Q000209:etiology / Q000235:genetics*; D008770:Methylnitrosourea / Q000633:toxicity; D051379:Mice; D009154:Mutation; D009381:Neoplasms, Radiation-Induced / Q000235:genetics; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras); D013953:Thymus Neoplasms / Q000139:chemically induced / Q000209:etiology / Q000235:genetics*; D014170:Transformation, Genetic
D004273:DNA, Neoplasm; D011518:Proto-Oncogene Proteins; D008770:Methylnitrosourea; D016283:Proto-Oncogene Proteins p21(ras)