title: Peripheral T-cell lymphoma presenting with angioedema and diffuse pulmonary infiltrates.
abstract: Peripheral T-cell lymphoma is becoming increasingly recognized as a clinical entity despite its protean clinical manifestations and morphological features. Pulmonary involvement is evident in 20% of patients at initial diagnosis and develops in a further 20% during the course of their disease. Angioedema resulting from immune-mediated complement depletion is a rare complication of B-cell tumors. It has not been reported in T-cell lymphoma. We describe a patient with peripheral T-cell lymphoma who presented with angioedema and diffuse pulmonary infiltrates. Normal serum complement levels suggest that this patient developed angioedema independent of abnormalities in the complement cascade.
authors.affiliation: Department of Thoracic Medicine, Brompton Hospital, London, United Kingdom.
authors.forename: N K
authors.initials: NK
authors.lastname: Harrison
authors.forename: C
authors.initials: C
authors.lastname: Twelves
authors.forename: B J
authors.initials: BJ
authors.lastname: Addis
authors.forename: A J
authors.initials: AJ
authors.lastname: Taylor
authors.forename: R L
authors.initials: RL
authors.lastname: Souhami
authors.forename: P G
authors.initials: PG
authors.lastname: Isaacson
mesh_terms: D000799:Angioedema / Q000175:diagnosis* / Q000473:pathology; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D013902:Radiography, Thoracic; D013601:T-Lymphocytes