Superactivated charcoal versus cholestyramine for cholesterol lowering: a randomized cross-over trial.
To evaluate the relative abilities of superactivated charcoal (20 g twice daily) and cholestyramine (8 g twice daily) to lower plasma cholesterol concentrations acutely, six hypercholesterolemic patients were studied using a randomized cross-over design. After a 1-week dietary control period, each subject received 3 weeks of each treatment regimen on separate occasions. Superactivated charcoal and cholestyramine reduced total plasma cholesterol by 21.8 +/- 3.8% and 16.2 +/- 2.4%, respectively. Side effects were mild and similar for both treatments. At the dosage regimens studied, superactivated charcoal and cholestyramine have comparable ability to lower plasma cholesterol concentrations.
Park
G D
GD
Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City.
Spector
R
R
Kitt
T M
TM
D000328:Adult; D000924:Anticholesteremic Agents; D002606:Charcoal / Q000009:adverse effects / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood*; D002792:Cholestyramine Resin / Q000009:adverse effects / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D000924:Anticholesteremic Agents; D014280:Triglycerides; D002792:Cholestyramine Resin; D002606:Charcoal; D002784:Cholesterol