title: Secreted peptides as regulators of neuron-glia and glia-glia interactions in the developing nervous system.
abstract: Secreted peptides of the nervous system help to regulate neuron-glia and glia-glia interactions during development. These regulatory factors, referred to as glia-promoting factors (GPFs), act on specific classes of glia and include oligodendroglia-stimulating peptides, interleukin-1 (IL-1), colony-stimulating factors (CSF), and fibroblast growth factor (FGF). The maturity of secretory and target cells determines, in part, the ability of a factor to influence glial proliferation, activation, or differentiation. During neural development, GPFs help to control such fundamentally important events as cell movement, neurite outgrowth, and myelination.
authors.affiliation: Department of Neurology, Baylor College of Medicine, Houston, TX 77030.
authors.forename: D
authors.initials: D
authors.lastname: Giulian
authors.forename: K
authors.initials: K
authors.lastname: Vaca
authors.forename: B
authors.initials: B
authors.lastname: Johnson
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D003115:Colony-Stimulating Factors / Q000378:metabolism / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000378:metabolism / Q000502:physiology; D007375:Interleukin-1 / Q000378:metabolism / Q000502:physiology; D009414:Nerve Growth Factors / Q000378:metabolism* / Q000502:physiology; D009457:Neuroglia / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D009474:Neurons / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D051381:Rats
chemical_list: D003115:Colony-Stimulating Factors; D007375:Interleukin-1; D009414:Nerve Growth Factors; D005346:Fibroblast Growth Factors