title: Azathioprine hypersensitivity. Case report and review of the literature.
abstract: Fever in a transplant recipient is an important sign of graft rejection or infection. Rarely, fever may result from an immunosuppressive agent used to prevent graft rejection. A case of fever, rigors, arthralgias, and myalgias is reported in a cardiac transplant recipient in whom azathioprine therapy was recently begun. These findings resolved on discontinuation of the azathioprine, recurred on rechallenge, and were most consistent with a hypersensitivity reaction. The clinical spectrum of reported azathioprine hypersensitivity reactions is reviewed.
authors.affiliation: Department of Medicine and Cardiovascular Surgery, University of Alabama at Birmingham Hospitals 35294.
authors.forename: P A
authors.initials: PA
authors.lastname: Saway
authors.forename: L W
authors.initials: LW
authors.lastname: Heck
authors.forename: J R
authors.initials: JR
authors.lastname: Bonner
authors.forename: J K
authors.initials: JK
authors.lastname: Kirklin
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000209:etiology*; D006084:Graft Rejection; D016027:Heart Transplantation; D006801:Humans; D008297:Male
chemical_list: D001379:Azathioprine