title: [Effect of copper and selenium on the histopathologic picture of the internal organs and the accumulation of these metals in hens].
abstract: The hens were given per os every second day for the period of 6 weeks selenium in the amount of 0.2 mg/l water (group I), 1.4 mg (group II), copper in amount of 1000 mg/kg feed (group III) and both metals jointly (group IV)--0.2 mg Se and 1000 mg Cu and group V--1.4 mg Se and 1000 mg Cu. Histopathological studies on hens organs and accumulation of metals in tissue were carried out. It was found that selenium in the amount of 1.4 mg/l water causes insignificant oedema of liver and kidneys, whereas copper (group III) shows clear hepato- and nephropathic effect. Selenium administered jointly with copper (group V) acts protectively in parenchymatous organs against the toxic effect of copper alone.
authors.affiliation: Katedra Anatomii Patologicznej i Weterynarii Sadowej.
authors.forename: J A
authors.initials: JA
authors.lastname: Madej
authors.forename: G
authors.initials: G
authors.lastname: Radzanowska
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D002645:Chickens / Q000378:metabolism*; D003300:Copper / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D004336:Drug Antagonism; D005260:Female; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D008107:Liver Diseases / Q000473:pathology / Q000662:veterinary*; D012643:Selenium / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014781:Viscera / Q000187:drug effects* / Q000473:pathology
chemical_list: D003300:Copper; D012643:Selenium
vernacular_title: Wpływ podawania Cu i Se na obraz histopatologiczny narzadów wewnetrznych oraz kumulacje metali w organizmie kur.