[Effects of opioid peptides on rats with a second heart transplanted into the abdominal cavity].
To determine whether opioid peptides have direct effects on myocardium we compared the effects of enkephalin analogs DAGO and DADL on both an innervated heart and a denervated heterotopically transplanted heart in the same animal. DAGO and DADL injected intravenously into anesthetized rats with two hearts produced hypotension, fall in end-systolic left ventricular pressure of both recipient's and donor's heart, bradycardia and decreasing of contractility in recipient's heart. Opioid peptides exerted no chronotropic effect and a slight positive inotropic effect on denervated transplanted heart. Both bradycardia and decreasing of contractility in recipient's heart have the neurogenic origin.
Martynova
E R
ER
Khalatov
V Iu
VIu
Medvedev
O S
OS
Akchurin
R S
RS
D000005:Abdomen; D000818:Animals; D006328:Cardiac Catheterization; D003714:Denervation; D004723:Endorphins / Q000494:pharmacology*; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine; D004745:Enkephalins / Q000494:pharmacology; D006321:Heart / Q000187:drug effects* / Q000294:innervation; D016027:Heart Transplantation; D006439:Hemodynamics / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D004723:Endorphins; D004745:Enkephalins; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D011433:Propranolol; D007545:Isoproterenol
Izuchenie éffektov opioidnykh peptidov na krysakh s transplantirovannym v briushnuiu polost' vtorym serdtsem.