Heart and kidney transplantation in the rat using a mixed cuff-stent microsurgical technique.
A method has been described for heart and kidney transplantation in rats using a mixed cuff-stent microsurgical technique. The advantages of the method include reduction of total ischemia time to an average of 11 minutes for heart grafting and 6 minutes for kidney grafting, provided donor and recipient operations are performed simultaneously; ease of performance and short training period, which allows the method to be employed by transplantation novices and to be extended to laboratories that lack experienced microsurgeons; and the possibility of applying the method to transplantation of other vascularized organs in the rat.
Marni
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Instituto di Patologia Generale, Università di Milano, Italy.
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D000818:Animals; D003331:Coronary Vessels; D016027:Heart Transplantation; D007511:Ischemia / Q000517:prevention & control; D007668:Kidney / Q000098:blood supply; D016030:Kidney Transplantation; D008297:Male; D008866:Microsurgery / Q000379:methods*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors