title: Therapeutic consequences of oesophageal function studies in patients with benign oesophageal disease.
abstract: Evaluation of oesophageal function was performed in 91 patients referred to a specialized department of cardiothoracic surgery for surgical treatment of benign oesophageal disease. Standard manometry was used in addition to radiology and endoscopy, and in some patients, an acid perfusion test, an acid clearing test, and a prolonged monitoring of pH in the distal oesophagus were additionally performed. The aim of this study was to evaluate whether assessment of oesophageal function is needed in such a patient group, and whether the results of these investigations were taken into account when making the final decision for therapy. Eleven percent of the patients referred with a diagnosis of hiatal hernia or reflux had achalasia or oesophageal spasm. Nine percent of the patients referred for motility disorders had reflux-related disease. The referral diagnosis was changed to a diagnosis with a different therapeutic approach in 16% of the patients. In 33%, a diagnosis of disordered oesophageal function was considered either at referral or during the routine assessment for oesophageal disease. Eighty-one percent of the patients with achalasia were treated in accordance with the manometric results. In all cases where an anatomical diagnosis was replaced by a diagnosis of disordered function, the treatment was in accordance with the findings of the motility studies. None of the patients with oesophageal spasm were suspected of having this disease. It is concluded, that not only anatomical features, but also functional considerations have to be taken into account when selecting treatment for benign oesophageal disease. Treatment failure and unnecessary surgical intervention can thus be avoided.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Odense University Hospital, Denmark.
authors.forename: E
authors.initials: E
authors.lastname: Jakobsen
authors.forename: S
authors.initials: S
authors.lastname: Kruse-Andersen
authors.forename: L
authors.initials: L
authors.lastname: Wallin
authors.forename: T
authors.initials: T
authors.lastname: Madsen
authors.forename: K
authors.initials: K
authors.lastname: Andersen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D004931:Esophageal Achalasia / Q000175:diagnosis; D004935:Esophageal Diseases / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D004938:Esophageal Neoplasms / Q000175:diagnosis; D015155:Esophageal Spasm, Diffuse / Q000175:diagnosis; D004941:Esophagitis / Q000175:diagnosis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008365:Manometry; D008875:Middle Aged; D008991:Monitoring, Physiologic