Expression of a metallothionein-vasopressin fusion gene in transgenic mice produces hypervasopressinemia and manifestations of nephrogenic diabetes insipidus.
Habener
J F
JF
Laboratory of Molecular Endocrinology, Harvard Medical School, Boston, MA 02114.
Cwikel
B
B
Hermann
H
H
Hammer
R E
RE
Palmiter
R D
RD
Brinster
R L
RL
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood / Q000235:genetics*; D001769:Blood; D004274:DNA, Recombinant; D003919:Diabetes Insipidus / Q000235:genetics*; D015870:Gene Expression; D008297:Male; D008668:Metallothionein / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D009481:Neurophysins / Q000235:genetics*; D009994:Osmolar Concentration; D010121:Oxytocin; D011498:Protein Precursors / Q000235:genetics*; D011499:Protein Processing, Post-Translational; D014667:Vasopressins / Q000097:blood* / Q000235:genetics
D004274:DNA, Recombinant; D009481:Neurophysins; D011498:Protein Precursors; D014667:Vasopressins; D001127:Arginine Vasopressin; D010121:Oxytocin; D008668:Metallothionein