title: Responses of human B-cells to recombinant lymphokines.
abstract: The effects of recombinant or purified cytokines on the growth and differentiation of human B-cells from a variety of sources were evaluated. The results suggest that IL-1, BCGF and BSF-2 have either "growth-factor" or "differentiation-factor" activity and that only IL-2 has both these functions. In addition, evidence is presented that the two forms of human IL-1 affect B-cell growth differently. Finally, the separation of human normal and leukaemic B-cells into subsets defined by their buoyant cell density, is described.
authors.affiliation: Immunology Division, University of Strathclyde, Todd Centre, Glasgow.
authors.forename: G
authors.initials: G
authors.lastname: Gallagher
authors.forename: N
authors.initials: N
authors.lastname: Taylor
authors.forename: J
authors.initials: J
authors.lastname: Willdridge
authors.forename: J F
authors.initials: JF
authors.lastname: Christie
authors.forename: W H
authors.initials: WH
authors.lastname: Stimson
mesh_terms: D001402:B-Lymphocytes / Q000145:classification / Q000276:immunology*; D002455:Cell Division; D002478:Cells, Cultured; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology; D015847:Interleukin-4; D015850:Interleukin-6; D007378:Interleukins / Q000276:immunology; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology*
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D007378:Interleukins; D008222:Lymphokines; D011994:Recombinant Proteins; D015847:Interleukin-4