UDS activity in the rat liver of the human carcinogens benzidine and 4-aminobiphenyl, and the rodent carcinogens 3,3'-dichlorobenzidine and direct black 38.
The activity of benzidine and three structurally related carcinogens in an in vivo/in vitro rat liver assay for unscheduled DNA synthesis is described. The first three of these chemicals, benzidine, 4-aminobiphenyl (4AB) and Direct Black 38 have been reported as positive in this assay by other investigators, albeit the data reported for 4AB were limited. The fourth compound, 3,3'-dichlorobenzidine has not been studied in this assay before. Each compound gave a clear positive response under conditions of routine testing.
Ashby
J
J
Imperial Chemical Industries Plc, Central Toxicology Laboratory, Macclesfield, Cheshire, UK.
Mohammed
R
R
D015101:3,3'-Dichlorobenzidine / Q000633:toxicity; D000611:Aminobiphenyl Compounds / Q000633:toxicity; D000818:Animals; D001391:Azo Compounds / Q000633:toxicity; D001560:Benzidines / Q000633:toxicity; D002273:Carcinogens / Q000633:toxicity*; D004261:DNA Replication / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D009153:Mutagens; D051381:Rats
D000611:Aminobiphenyl Compounds; D001391:Azo Compounds; D001560:Benzidines; D002273:Carcinogens; D009153:Mutagens; C006757:4-biphenylamine; D015101:3,3'-Dichlorobenzidine; C029876:benzidine; C015844:direct black 3