title: Nonmutagenicity of maleic acid and its sodium salts in salmonella assays.
abstract: Maleic acid (cis-butenedioic acid) and its mono- and disodium salts are shown to be non-mutagenic in the standard Ames Salmonella/mammalian microsome assay in the absence and presence of Aroclor-1254-induced rat liver S9. This lack of activity occurred despite depression of top agar pH in accordance with the degree of protonation of this polybasic acid. These results indicate that when chemical compounds which are maleate salts show activity in this assay, the effect is attributable to the base moiety rather than maleate or pH depression per se.
authors.affiliation: Safety Evaluation Center, Schering Corporation, Lafayette, NJ 07848.
authors.forename: R S
authors.initials: RS
authors.lastname: Lake
authors.forename: G L
authors.initials: GL
authors.lastname: DeVito
authors.forename: R J
authors.initials: RJ
authors.lastname: Szot
authors.forename: E
authors.initials: E
authors.lastname: Schwartz
mesh_terms: D006863:Hydrogen-Ion Concentration; D008298:Maleates / Q000633:toxicity*; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D008298:Maleates; C030272:maleic acid