title: Investigation of the skin thinning effect of prednicarbate and other corticoids in mouse skin.
abstract: In this investigation skin fold thinning was determined after topical application of several potent corticosteroids in hairless mice using a simple mechanical measuring device. The skin thinning effect of prednicarbate was compared with other corticosteroids (amcinonide, beta-methasone-17-valerate, clobetasol-17-propionate, diflorasone-17,21-diacetate, hydrocortisone-21-acetate). Prednicarbate produced a clear thinning of skin. Like other tested dermatocorticoids prednicarbate caused a significant atrophy of the mouse tail epidermis. By prednicarbate the 3H-thymidine triphosphate incorporation into epidermal DNA was inhibited.
authors.affiliation: Department of Dermatology, Hautklinik Linden, Medizinische Hochschule Hannover, FRG.
authors.forename: D
authors.initials: D
authors.lastname: Lubach
authors.forename: M
authors.initials: M
authors.lastname: Kietzmann
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D005260:Female; D006639:Histidine / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D051379:Mice; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D012867:Skin / Q000033:anatomy & histology* / Q000187:drug effects; D013936:Thymidine / Q000378:metabolism
chemical_list: D000305:Adrenal Cortex Hormones; D000596:Amino Acids; D000893:Anti-Inflammatory Agents; D006639:Histidine; D004247:DNA; D011239:Prednisolone; D007930:Leucine; C035287:prednicarbate; D013936:Thymidine