[Ammonia release and binding processes and the activity of acid proteinase and glycolysis enzymes in the dynamics of experimental toxic adrenal encephalopathy].
The content of ammonium, glutamine, glutamate, aspartate and GABA, glutamine synthetase activity, acid proteinase, hexonase, phosphohexoisomerase and dehydrogenase glucose-6-phosphate were studied in dog brain homogenates after individual injections of Bacillus coli endotoxin (10 micrograms/kg) and adrenaline (75 micrograms/kg) into veins and their combined injections into the carotid artery. Isolated injections of endotoxin and adrenaline were shown to cause transient metabolic compensatory changes. Combined injections caused stable progressing brain metabolic disorders. It is suggested that neurochemical changes influence endogenous development of toxic adrenal encephalopathy.
Kovalenko
V M
VM
Trapezontseva
R A
RA
Vilkov
G A
GA
D000641:Ammonia / Q000378:metabolism*; D000818:Animals; D016282:Aspartic Acid Endopeptidases; D001927:Brain Diseases / Q000209:etiology / Q000378:metabolism*; D004285:Dogs; D010450:Endopeptidases / Q000378:metabolism*; D004731:Endotoxins / Q000008:administration & dosage; D004837:Epinephrine / Q000008:administration & dosage; D004926:Escherichia coli; D005260:Female; D005956:Glucose-6-Phosphate Isomerase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006593:Hexokinase / Q000378:metabolism; D008297:Male
D004731:Endotoxins; D000641:Ammonia; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; D005956:Glucose-6-Phosphate Isomerase; D004837:Epinephrine
Protsessy osvobozhdeniia i sviazyvaniia ammiaka, aktivnost' kisloĭ proteinazy i fermentov glikoliza v dinamike éksperimental'noĭ toksiko-adrenalovoĭ éntsefalopatii.