title: Lower respiratory illness in early childhood and lung function and bronchial reactivity in adolescent males.
abstract: We examined the relationship between lower respiratory illness (LRI) experience in early childhood and lung function and bronchial reactivity in 57 boys, 11 to 22 yr of age, whose histories of outpatient physician visits for wheezing and nonwheezing LRI had been documented prospectively during their first 6 yr of life. These boys were a subpopulation of 159 children whose early childhood LRI experience and spirometric performance had been studied an average of 4 yr previously. The majority of boys had been free of chronic respiratory symptoms in the 2 yr before evaluation. Boys with histories of 2 or more preschool wheezing illnesses had lower mean levels of performance for FEV1, FEF25-75, FEF50, FEF75, and FEV1/FVC than did boys who had zero or 1 preschool wheezing illness, replicating observations that had been made when the boys had been studied 4 yr previously. Boys with lower spirometric performance relative to the study population on initial testing continued to have lower relative levels of spirometric performance 4 yr later. Neither preschool wheezing nor nonwheezing illness experience was associated with the degree of methacholine sensitivity measured in adolescence. Increasing degrees of methacholine sensitivity were associated with lower levels of spirometric performance; however, preschool wheezing illness experience remained a significant correlate of spirometric performance after adjustment for level of methacholine sensitivity. We conclude that recurrent preschool wheezing illness in these adolescent boys was associated with persistently lower lung function, but not enhanced methacholine sensitivity, during the middle to late school years.
authors.affiliation: Department of Pediatrics, School of Medicine, University of North Carolina, Chapel Hill 27514.
authors.forename: K Z
authors.initials: KZ
authors.lastname: Voter
authors.forename: M M
authors.initials: MM
authors.lastname: Henry
authors.forename: P W
authors.initials: PW
authors.lastname: Stewart
authors.forename: F W
authors.initials: FW
authors.lastname: Henderson
mesh_terms: D000293:Adolescent; D001980:Bronchi / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds; D012135:Respiratory Sounds / Q000503:physiopathology; D012141:Respiratory Tract Infections / Q000503:physiopathology*; D013147:Spirometry; D014797:Vital Capacity
chemical_list: D008688:Methacholine Compounds; D016210:Methacholine Chloride