[Nasal provocation using histamine. A comparison of threshold determination using 3 methods of rhinomanometry].
Three methods of rhinomanometry were compared with each other with respect to their ability to determine the histamine threshold (histamine concentration for a 100% increase of the initial total nasal resistance): the active anterior rhinomanometry (AAR), the active posterior rhinomanometry (APR) and the passive anterior rhinomanometry (PAR). Nasal challenge and consecutive measurement by the three methods of rhinomanometry were conducted in a group of 11 volunteers. The three methods gave significantly different histamine concentration thresholds (p = 0.002). Unilateral histamine thresholds as available from AAR and PAR (at a flow of 250 cm3/sec) did not differ significantly (p = 0.299). For AAR and APR, histamine thresholds were assessed at 5 different pressure values as well as at 5 different flow values. The thresholds did not appear to be significantly different at any one of those pressure gradients (p = 0.690) or flow values (p = 0.357).
Gordts
F
F
VUB, Brussel, België.
Clement
P A
PA
Derde
M P
MP
D000328:Adult; D000403:Airway Resistance; D005260:Female; D006632:Histamine; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods; D009299:Nasal Provocation Tests / Q000379:methods*; D011312:Pressure
D006632:Histamine
Neusprovocatie met histamine. Een vergelijking van de drempelbepaling aan de hand van drie rhinomanometrie-methoden.