The metabolism of aromatic ring fission products by Bacillus stearothermophilus strain IC3.
Bacillus stearothermophilus IC3 degraded the meta cleavage product of catechol, 2-hydroxymuconic semialdehyde, to pyruvate and acetaldehyde via the 4-oxalocrotonate pathway. The pathway was identical to those previously delineated in several mesophilic organisms. However, all the enzymes showed activity at 55 degrees C and other properties (substrate specificities and effects of metal ions) also differed from those displayed by the mesophilic enzymes. All enzymes of this meta cleavage pathway, except the 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase and 4-hydroxy-2-oxovalerate aldolase activities, were induced by growth on phenol.
Adams
D
D
Centre for Biotechnology, Imperial College of Science and Technology, London, UK.
Ribbons
D W
DW
D002396:Catechols / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D001411:Geobacillus stearothermophilus / Q000201:enzymology / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D009243:NAD / Q000494:pharmacology; D019800:Phenol; D010636:Phenols / Q000494:pharmacology
D002396:Catechols; D005231:Fatty Acids, Unsaturated; D010636:Phenols; D009243:NAD; C002091:hydroxymuconic semialdehyde; D019800:Phenol; D005947:Glucose