title: Effects of systemic morphine and epidural bupivacaine on postoperative oxygen consumption during rewarming.
abstract: The alterations in hemodynamics and oxygen consumption as a consequence of continuous epidural infusions of bupivacaine at room temperature and conventionally administered morphine were studied during recovery from general anesthesia for total hip replacement. Twenty-four patients were randomized to receive either bupivacaine or morphine in the recovery room. The bupivacaine group received from 6 to 12 ml per hour of 0.25% bupivacaine epidurally. Patients in the morphine group received 0.1 mg/kg of morphine intramuscularly no more frequently than every 4 hours. A pulmonary artery flotation catheter was inserted into each patient to determine hemodynamics and oxygen consumption at three instances: before analgesia, when pulmonary artery blood temperature reached 36 degrees C, and when it reached 37 degrees C. During the rewarming there was a decrease in mean arterial blood pressure and the systemic vascular resistance index and an increase in heart rate. The whole body oxygen consumption index increased in the bupivacaine group at the last measuring point but was stable in the morphine group. There was no effect on the arterial-venous oxygen content difference in either group. At 37 degrees C, the cardiac index and oxygen consumption index were significantly higher in the bupivacaine group than in the morphine group. In contrast to regional analgesia, systemic morphine administration can partially antagonize cardiovascular response to postoperative rewarming because it induces a stable oxygen demand.
authors.affiliation: Département d'Anesthésiologie, Hôtel-Dieu, Centre Hospitalier Universitaire, Nantes, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Bernard
authors.forename: B
authors.initials: B
authors.lastname: Bourreli
authors.forename: M
authors.initials: M
authors.lastname: Pinaud
mesh_terms: D000368:Aged; D015360:Analgesia, Epidural; D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature; D002045:Bupivacaine / Q000008:administration & dosage*; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006622:Hip Prosthesis; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage*; D010101:Oxygen Consumption / Q000187:drug effects*; D010149:Postoperative Pain / Q000517:prevention & control*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D009020:Morphine; D002045:Bupivacaine