title: The effect of trauma to the leg on the first-pass uptake of bacteria by the lung.
abstract: Our previous studies have shown that the first-pass pulmonary uptake of lidocaine and serotonin were not impaired by bullet wounding of the leg. Since there is decreased resistance to bacterial infection with trauma, it was of interest to study the uptake of bacteria. First-pass pulmonary uptake of 51-chromium-labeled, killed Salmonella typhimurium bacteria was studied in 26 pigs. In 16 controls, four injections at hourly intervals revealed an initial uptake of 84.5% +/- 1.5 (Mean +/- S.E.M.) and a 95% first-pass uptake of 78.6% +/- 2.4, and no significant change with time. In the ten traumatized animals only the values at 5 hours were significantly lower than the controls. It is concluded that repeated injections of killed Salmonella typhimurium bacteria without trauma do not interfere with the ability of the lung to remove these bacteria during their first passage through the lung, but that with trauma to the leg do to a slight degree.
authors.affiliation: Clinical Research Center, University Hospital, Linköping, Sweden.
authors.forename: K E
authors.initials: KE
authors.lastname: Behm
authors.forename: K
authors.initials: K
authors.lastname: Falk
authors.forename: T
authors.initials: T
authors.lastname: Skogh
authors.forename: D H
authors.initials: DH
authors.lastname: Lewis
mesh_terms: D000818:Animals; D007869:Leg Injuries / Q000503:physiopathology*; D008168:Lung / Q000503:physiopathology*; D012486:Salmonella typhimurium / Q000276:immunology*; D013552:Swine; D014948:Wounds, Gunshot / Q000503:physiopathology*