Electrophysiological measures of visual and auditory function as indices of neurotoxicity.
The application of auditory and visual evoked potentials (VEP) to neurotoxicity testing of humans and animals is reviewed. VEPs elicited by flash, reversing-checkerboard patterns, and sine wave grating are described. The flask evoked potential in rats is altered by exposure to many heavy metals, pesticides and solvents. The brainstem auditory evoked potential also appears to be sensitive to neurotoxic chemicals, but the evidence available is limited. The homology of auditory and visual evoked potentials in rats and humans is useful for cross-species extrapolation in neurotoxicology research.
Otto
D
D
Neurotoxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.
Hudnell
K
K
Boyes
W
W
Janssen
R
R
Dyer
R
R
D000818:Animals; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D006801:Humans; D009420:Nervous System / Q000187:drug effects*