In situ localization of murine c-Ki-ras-2 oncogene: preliminary evidence for conservation of telomeric territory of oncogenes?
The use of a human cDNA probe and a Robertsonian translocation marker allowed us to localize the murine c-Ki-ras-2 oncogene to 6F-G at the telomere. Our finding provides support for the hypothesis that oncogenes have a preferred telomeric territory that is evolutionarily conserved. Given our physical mapping of c-Ki-ras-2 to 6F-G, the role of this oncogene in the genesis and/or maintenance of granulocytic leukemias can now be explored by correlating the oncogenic site to that of the structural rearrangement of chromosome 6 seen in the tumors.
Martin-DeLeon
P A
PA
School of Life and Health Sciences, University of Delaware, Newark 19716.
Picciano
S R
SR
D000818:Animals; D001483:Base Sequence; D002871:Chromosome Banding; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D011905:Genes, ras; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D051379:Mice; D011519:Proto-Oncogenes; D012689:Sequence Homology, Nucleic Acid; D014178:Translocation, Genetic
D005819:Genetic Markers; D004247:DNA