Prevention of early postoperative renal dysfunction in cardiac transplantation.
Fifty six patients undergoing cardiac transplantation were immunosuppressed with a multi-drug induction regimen in which Cs administration was delayed postoperatively until satisfactory hemodynamics and renal function were achieved. The advantage of this approach is the absence of acute renal dysfunction in the early postoperative period. This immunosuppressive regimen was well tolerated and without significant detrimental effects on patient survival, graft rejection, or infection.
Keith
F M
FM
Division of Thoracic Surgery, Henry Ford Hospital, Detroit, MI 48202.
Magilligan
D J
DJ
Lakier
J B
JB
Drost
C J
CJ
D000961:Antilymphocyte Serum / Q000008:administration & dosage; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000097:blood; D016027:Heart Transplantation; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007674:Kidney Diseases / Q000517:prevention & control
D000961:Antilymphocyte Serum; D003524:Cyclosporins; D003404:Creatinine