Reactions in rat gluteal muscle to titanium implants.
A new approach to the analysis of tissue-implant interaction is presented using rat gluteal muscle as implantation site and using monoclonal antibodies to identify and quantify cells around the implant. The method can be used for comparative studies on biocompatibility. In this methodological investigation, pure titanium (Ti) was studied, revealing an initial response of macrophages, followed by the formation of a fibrous membrane, in which, even at 50 and 70 d, la-expressing cells and suppressor T-lymphocytes were present.
Lindberg
L R
LR
Department of Orthopaedics, Malmö General Hospital, Lund University, Sweden.
Johnell
O
O
Linder
L
L
D000818:Animals; D000911:Antibodies, Monoclonal; D001672:Biocompatible Materials; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D009132:Muscles / Q000276:immunology / Q000473:pathology*; D019736:Prostheses and Implants; D051381:Rats; D011917:Rats, Inbred Lew; D014025:Titanium
D000911:Antibodies, Monoclonal; D001672:Biocompatible Materials; D000949:Histocompatibility Antigens Class II; D014025:Titanium