[Effect of levamisole on the cellular and humoral immunity indices in patients with chronic brucellosis].
In chronic brucellosis patients receiving levamisole and placebo the dynamics of quantitative and functional characteristics of cell-mediated and humoral immunity have been studied. The immunomodulating effect of levamisole, manifested only in the process of treatment by a rise in the number of circulating lymphoid cells, their functional capacity, a decrease in the disproportion of immunoregulatory cells and the amount of circulating immune complexes, has been established. The positive dynamics of immunological characteristics have been found to improve both immediate and remote results of the clinical effectiveness of levamisole.
Mukovozova
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LA
D000276:Adjuvants, Immunologic; D000293:Adolescent; D000328:Adult; D000917:Antibody Formation / Q000187:drug effects; D000936:Antigen-Antibody Complex / Q000032:analysis; D002006:Brucellosis / Q000188:drug therapy* / Q000276:immunology; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007978:Levamisole / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D000936:Antigen-Antibody Complex; D007978:Levamisole
Vliianie levamizola na nekotorye pokazateli kletochnogo i gumoral'nogo immuniteta u bol'nykh khronicheskim brutsellezom.