[Mutagenesis and responses induced by DNA damage in Escherichia coli: principle of bacterial tests for detecting carcinogenic or antitumoral substances].
Various bacterial tests are used for the detection of potential carcinogenic or antitumoral agents. These so-called short-term tests measure different processes triggered by DNA damage: mutagenesis ("Mutatest"), induction of genes that belong to the recA-lexA regulon ("Umu-test" and "SOS-chromotest"), and induction of provirus ("Inductest"). Although these tests share common properties, each exhibits characteristic properties which are revealed by analyzing the various DNA repair mechanisms brought about in E. coli.
Moreau
P L
PL
Laboratoire d'enzymologie, CNRS, Gif-sur-Yvette, France.
D004249:DNA Damage; D004269:DNA, Bacterial / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D009152:Mutagenicity Tests; D009154:Mutation
D004269:DNA, Bacterial
Mutagénèse et réponses induites par l'endommagement de l'ADN chez Escherichia coli: principe des tests bactériens pour la détection des substances cancérogènes ou antitumorales.