[Hemodynamic effects of different antihypertensive combinations].
The haemodynamic effects of combinations of antihypertensive drugs were tested in an open trial on 15 patients with essential arterial hypertension. The following combinations were used: Piretanid/Captopril, Piretanid/Urapidil and Acebutolol/Piretanid. All three combinations significantly lowered arterial pressure at rest and on exercise. Both Piretanid/Captopril and Piretanid/Urapidil reduced the arterial pressure exclusively by reduction of the peripheral resistance, while cardiac output rose. On the other hand, Acebutolol/Piretanid reduced the blood pressure through reduction of cardiac output, less so by lowering the peripheral resistance. Mean pulmonary arterial pressure, as a measure of left-ventricular filling pressure, fell under Piretanid/Captopril and Piretanid/Urapidil, remaining high under Acebutolol/Piretanid. Thus the combinations of Piretanid/Captopril and Piretanid/Urapidil are most likely to fulfill the demands to be placed on an "ideal" antihypertensive treatment.
Wiechmann
H W
HW
Medizinische Universitätsklinik der Ruhr-Universität Bochum, Marienhospital Herne 1.
D000070:Acebutolol / Q000008:administration & dosage; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002216:Captopril / Q000008:administration & dosage; D002908:Chronic Disease; D004232:Diuretics / Q000008:administration & dosage; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000008:administration & dosage; D011897:Random Allocation; D013449:Sulfonamides / Q000008:administration & dosage; D013997:Time Factors
D000959:Antihypertensive Agents; D004232:Diuretics; D010879:Piperazines; D013449:Sulfonamides; D000070:Acebutolol; D002216:Captopril; C015568:urapidil; C015451:piretanide
Hämodynamische Wirkungen verschiedener antihypertensiver Kombinationen.