Double blind controlled randomized study on azathioprine efficacy in multiple sclerosis. Preliminary results.
The preliminary results of a double blind controlled prospective randomized trial of Azathioprine for therapeutic efficacy in 38 patients with Multiple Sclerosis are reported. Progression of the disease is significantly reduced in Azathioprine-treated group in comparison to Placebo-treated patients, but this effect is reached only after 3 years of treatment (P less than 0.025) regardless of the clinical course and without affecting relapse rate.
Milanese
C
C
Istituto Neurologico, C. Besta, Milano.
La Mantia
L
L
Salmaggi
A
A
Campi
A
A
Bortolami
C
C
Tajoli
L
L
Nespolo
A
A
Corridori
F
F
D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy*; D011897:Random Allocation
D001379:Azathioprine