title: High salt diet decreases longevity in the spontaneously hypertensive rat.
abstract: 1. Blood pressure, body weight and mortality rate were examined in female spontaneously hypertensive rats (SHR) of the Okamoto strain maintained on a lifelong high (5% NaCl w/w) or low (0.1% NaCl w/w) salt diet. 2. A high salt diet increased mortality and decreased body weight in SHR, but failed to significantly alter blood pressure up to 24 months of age. 3. Hence, a low salt diet does not appear to be a long-term risk factor and may protect the SHR from cardiovascular accidents.
authors.affiliation: Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Di Nicolantonio
authors.forename: M J
authors.initials: MJ
authors.lastname: Silvapulle
authors.forename: S
authors.initials: S
authors.lastname: Spargo
authors.forename: T O
authors.initials: TO
authors.lastname: Morgan
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006973:Hypertension / Q000503:physiopathology*; D008136:Longevity; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D012307:Risk Factors; D012982:Sodium, Dietary / Q000494:pharmacology*
chemical_list: D012982:Sodium, Dietary