Transforming activity of the human mammary line HBL100 DNA is associated with SV40 large T antigen genetic information integrated in its genome.
The HBL100 cell line, established in vitro from milk of an apparently healthy woman, expresses SV40 large T antigen defective in some of its functions. Here we demonstrate that the HBL100 genomic DNA possesses transforming activity in NIH3T3 cells and that this activity is associated with the viral information.
Vanhamme
L
L
Université Libre de Bruxelles, Département de Biologie Moléculaire, Rhode-St-Genèse, Belgium.
Szpirer
C
C
D000952:Antigens, Polyomavirus Transforming / Q000235:genetics*; D001940:Breast; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic; D005260:Female; D005814:Genes, Viral; D006801:Humans; D007124:Immunoenzyme Techniques
D000952:Antigens, Polyomavirus Transforming