title: Differential effects of inflammation models on rat T-kininogen and rat angiotensinogen.
abstract: The effect of different experimental models of inflammation on plasma concentrations of T-kininogen and angiotensinogen was examined in the rat. T-kininogen, a major phase protein which inhibits cysteine proteinase is increased in all cases of induced inflammation: administration of lipopolysaccharide and turpentine, bilateral nephrectomy or sham-operation and intraperitoneal injection of peanut oil. Angiotensinogen, the renin-substrate, is increased by lipopolysaccharide but is decreased by turpentine. Sham-operation or peanut oil injection have no effect on angiotensinogen whereas, bilateral nephrectomy and dexamethasone increase its concentration. Therefore, angiotensinogen is regulated differently than T-kininogen during inflammation.
authors.affiliation: INSERM U36, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Bouhnik
authors.forename: F
authors.initials: F
authors.lastname: Savoie
authors.forename: P
authors.initials: P
authors.lastname: Corvol
mesh_terms: D000808:Angiotensinogen / Q000097:blood*; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D007249:Inflammation / Q000097:blood*; D007704:Kininogens / Q000097:blood*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D014425:Turpentine / Q000494:pharmacology
chemical_list: D007704:Kininogens; D008070:Lipopolysaccharides; D000808:Angiotensinogen; D003907:Dexamethasone; D012083:Renin; D014425:Turpentine