An ongoing surveillance study of persistent crying and hypotonic-hyporesponsive episodes following routine DTP immunization: a preliminary report.
Hypotonic-hyporesponsive episodes and persistent crying are specific complications of pertussis immunization. Hyperinsulinemia, hypoglycemia, and leukocytosis have been noted after pertussis vaccine administration in a murine model. Five children with hypotonic-hyporesponsive episodes and 6 children with persistent crying following DTP immunization were studied. The children were found to have leukocytosis acutely, similar to findings reported in children following routine DTP immunization. No abnormalities were noted in plasma insulin or serum glucose. Five of 6 children with persistent crying had severe local reactions, suggesting that localized inflammation may be a cause of persistent crying.
Blumberg
D A
DA
Department of Pediatrics, UCLA School of Medicine 90024.
Morgan
C A
CA
Lewis
K
K
Leach
C
C
Holtzman
A
A
Levin
S R
SR
Baraff
L J
LJ
Cherry
J D
JD
D003448:Crying; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects* / Q000032:analysis; D004731:Endotoxins / Q000009:adverse effects / Q000032:analysis; D006801:Humans; D007223:Infant; D007964:Leukocytosis / Q000209:etiology; D009123:Muscle Hypotonia / Q000209:etiology; D012769:Shock / Q000209:etiology
D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004731:Endotoxins