[Anaphylactic reaction to human insulin. Successful desensitization].
A 48-year-old woman with diabetes mellitus (type IIb) had to be treated with insulin because of poor blood-sugar control. Infiltrates at the sight of injection occurred with two different porcine insulin preparations, necessitating a switch to human insulin. After the third injection of the latter an anaphylactic reaction developed within minutes. During a pregnancy in 1968 the patient had briefly received bovine insulin. Tests now revealed an immediate-type allergy against all three available species insulins, which was successfully treated by hyposensitisation.
Wintermantel
C
C
Medizinische Klinik und Poliklinik, Universität Tübingen sowie III.
Fischer
N
N
Müller
P H
PH
Velcovsky
H G
HG
Lischka
G
G
Eggstein
M
M
D000707:Anaphylaxis / Q000139:chemically induced* / Q000517:prevention & control; D000818:Animals; D002417:Cattle; D003888:Desensitization, Immunologic; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007328:Insulin / Q000009:adverse effects* / Q000276:immunology; D007330:Insulin Antibodies / Q000032:analysis; D008875:Middle Aged; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000188:drug therapy; D013045:Species Specificity; D013552:Swine; D013997:Time Factors
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007328:Insulin; D007330:Insulin Antibodies
Anaphylaktische Reaktion auf Humaninsulin. Erfolgreiche Hyposensibilisierung.