title: Expression of Ha-ras oncogene products in human neuroblastomas and the significant correlation with a patient's prognosis.
abstract: Neuroblastomas represent a spectrum of diseases categorized by histological subtypes, age of the patient, and extent of tumor (stage) at diagnosis. In this study we analyzed Ha-ras p21 (protein with molecular weight of 21,000) expression immunohistochemically on 47 primary human neuroblastomas resected at diagnosis. The data demonstrate that the amount of the Ha-ras product correlates with a favorable prognosis (P less than 0.001) and early stages of disease at diagnosis (P less than 0.05). These findings from unmanipulated human neuroblastomas indicate that the Ha-ras gene product (p21) might play a role in the mechanism(s) controlling aggressiveness in this type of tumor in vivo and that the Ha-ras p21 detected by a simple and reproducible immunohistochemical procedure may be of clinical importance in predicting prognosis in patients with this malignancy.
authors.affiliation: Department of Pediatrics, National Kure Hospital, Hiroshima, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: D J
authors.initials: DJ
authors.lastname: Slamon
authors.forename: H
authors.initials: H
authors.lastname: Shimoda
authors.forename: C
authors.initials: C
authors.lastname: Waki
authors.forename: Y
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: N
authors.initials: N
authors.lastname: Ida
mesh_terms: D000008:Abdominal Neoplasms / Q000235:genetics; D000310:Adrenal Gland Neoplasms / Q000235:genetics; D002675:Child, Preschool; D011905:Genes, ras; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008565:Membrane Proteins / Q000032:analysis*; D009447:Neuroblastoma / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D016283:Proto-Oncogene Proteins p21(ras); D013899:Thoracic Neoplasms / Q000235:genetics
chemical_list: D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)