Behavioral pharmacology of cocaine.
Laboratory data suggest that animals self-administer cocaine in patterns similar to those seen in humans. Conditions of availability and species are relatively unimportant determinants of cocaine self-administration. Furthermore, studies have shown that animals will continue to self-administer the drug, even in the face of severe toxic side effects. The data indicate that cocaine is a potent reinforcer with significant abuse liability. The animal self-administration model and laboratory data concerning self-administration in humans show cross-species generality and provide useful information about cocaine's behavioral mechanisms of action.
Fischman
M W
MW
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002415:Cats; D003042:Cocaine / Q000494:pharmacology; D006801:Humans; D008253:Macaca mulatta; D010215:Papio; D051381:Rats; D012646:Self Administration; D019966:Substance-Related Disorders / Q000523:psychology*
D003042:Cocaine