title: In vitro and clinical evaluation of ofloxacin in urinary tract infection and enteric fever.
abstract: During 1984 to 1988, 35 patients with urinary tract infection (UTI) and 37 patients with enteric fever were treated successfully with 400 mg ofloxacin twice a day for 7 to 10 days. Clinical cure or improvement was observed in 31 of the 35 patients with UTI; 32 patients were bacteriologically assessed and eradication was achieved in all of them. Ofloxacin was particularly effective in the treatment of enteric fever in 35 patients; eradication was achieved in all of them; 34 patients were clinically cured within 4 days, however, one patient with bacteraemia due to Salmonella paratyphi A subsequently died, due to his underlying disorder. The MIC90 of the Enterobacteriaceae including Salmonella was less than 0.12 micrograms/ml. Interestingly, beta-lactamase-producing strains of Salmonella and other Enterobacteriaceae in the present study were 28% and 29%, respectively. Ofloxacin therefore offers an effective b.i.d. dosage schedule for enteric fever and UTI due to beta-lactamase-producing bacteria.
authors.affiliation: Mahidol University, Bangkok, Thailand.
authors.forename: D
authors.initials: D
authors.lastname: Tanphaichitra
authors.forename: S
authors.initials: S
authors.lastname: Srimuang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000627:therapeutic use*; D012475:Salmonella / Q000187:drug effects / Q000201:enzymology; D014435:Typhoid Fever / Q000188:drug therapy*; D014552:Urinary Tract Infections / Q000188:drug therapy*; D001618:beta-Lactamases / Q000096:biosynthesis
chemical_list: D015242:Ofloxacin; D001618:beta-Lactamases