title: Topical antibiotics in the high-risk biliary surgical patient. A prospective, randomized study.
abstract: This randomized, prospective study has evaluated the efficacy of topical antibiotics in preventing infective complications in patients undergoing high-risk biliary surgery. Sixty-nine patients who underwent bile duct exploration, choledochoenteric anastomosis, or cholecystectomy, either for acute cholecystitis or because they were older than 65 years of age, were randomized to the following three groups: Group I, topical antibiotics alone (22 patients); Group II, cefoxitin and topical antibiotics (24 patients); and Group III, penicillin, tobramycin, clindamycin, and topical antibiotics (23 patients). The incidence of infective complications was no different among the groups. There was one wound infection in each group, one episode of bacteremia in Group II, and no intraabdominal abscesses. This study has demonstrated that parenteral antibiotics administered prophylactically in the perioperative period offer no additional benefit over the use of effective topical antibiotics used intraoperatively in patients undergoing high-risk biliary surgery.
authors.affiliation: Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
authors.forename: M G
authors.initials: MG
authors.lastname: Sarr
authors.forename: K J
authors.initials: KJ
authors.lastname: Parikh
authors.forename: H
authors.initials: H
authors.lastname: Sanfey
authors.forename: S L
authors.initials: SL
authors.lastname: Minken
authors.forename: J L
authors.initials: JL
authors.lastname: Cameron
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001662:Biliary Tract Surgical Procedures; D002440:Cefoxitin / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000627:therapeutic use; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014031:Tobramycin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D010406:Penicillins; D002981:Clindamycin; D002440:Cefoxitin; D014031:Tobramycin