The effect of methotrexate upon tumour ATP as determined by in vivo 31P inversion spin transfer.
The effect of methotrexate upon tumour growth in the hind leg muscle of rats containing a transplanted mammary adenocarcinoma was investigated by 31P magnetic resonance spectroscopy. Using inversion-transfer techniques, ATP resonances arising from the tumour could be distinguished from those arising from surrounding skeletal muscle. Methotrexate was shown to inhibit, but not prevent, tumour growth as evidenced by the tumour ATP resonances of methotrexate treated animals compared to those of control animals. These findings correlated with decreased tumour volume and enhanced life expectancy.
Haseler
L J
LJ
School of Science, Griffith University, Brisbane, Australia.
Irving
M G
MG
Doddrell
D M
DM
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D008727:Methotrexate / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains
D000255:Adenosine Triphosphate; D008727:Methotrexate