Non-co-ordinate expression of HLA-DR antigens and invariant chain.
The expression of HLA-DR and MHC class II antigen-associated invariant chain (Ii) was studied in normal colorectal mucosa, adenomas and carcinomas using monoclonal antibodies and a sensitive immunoperoxidase technique on frozen sections. In six of 15 specimens of normal mucosa, epithelial cells expressed Ii, but were unreactive for HLA-DR antigens. In 15/20 adenomas and 51/70 carcinomas, Ii-positive tumour cells clearly outnumbered HLA-DR-positive tumour cells. Expression of Ii in non-neoplastic epithelium adjacent to carcinoma was much stronger than expression of HLA-DR. The results indicate that in certain tissues expression of these two antigens is not closely associated.
Momburg
F
F
Institute of Pathology, Unviersity of Heidelberg, FRG.
Möller
P
P
D000236:Adenoma / Q000276:immunology; D000944:Antigens, Differentiation, B-Lymphocyte; D000951:Antigens, Neoplasm / Q000032:analysis*; D002277:Carcinoma / Q000276:immunology; D003110:Colonic Neoplasms / Q000276:immunology; D006681:HLA-D Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D007413:Intestinal Mucosa / Q000276:immunology; D012004:Rectal Neoplasms / Q000276:immunology
D000944:Antigens, Differentiation, B-Lymphocyte; D000951:Antigens, Neoplasm; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; C045084:invariant chain