Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human.
The growth-associated protein (GAP-43) is considered a crucial component of an effective regenerative response in the nervous system. Its phosphorylation by protein kinase C correlates with long-term potentiation. Sequence analysis of human cDNAs coding for this protein shows that the human GAP-43 gene is highly homologous to the rat gene; this homology extends into the 3'-untranslated region. However, the human protein contains a 10 amino acid insert. Somatic cell hybrids demonstrate localization of the GAP-43 gene to human chromosome 3 and to mouse chromosome 16.
Kosik
K S
KS
Department of Neurology (Neuroscience), Harvard Medical School, Boston, Massachusetts 02115.
Orecchio
L D
LD
Bruns
G A
GA
Benowitz
L I
LI
MacDonald
G P
GP
Cox
D R
DR
Neve
R L
RL
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002893:Chromosomes, Human, Pair 3; D019922:GAP-43 Protein; D005796:Genes; D006801:Humans; D008562:Membrane Glycoproteins / Q000032:analysis / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D019922:GAP-43 Protein; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins