Genotoxicity of 6 oxime compounds in the salmonella/mammalian-microsome assay and mouse lymphoma TK +/- assay.
To aid in the selection of chemical candidates for in vivo tests, the mutagenicity of 6 oxime compounds was evaluated in the Salmonella plate incorporation assay and mouse lymphoma L5178Y TK +/- assay. All of the oximes were mutagenic in the mouse lymphoma assay in the absence of exogenous metabolic activation. Acetaldehyde oxime was also mutagenic in the presence of S9 activation. In contrast to these results, a positive response was noted only for 2-(hydroxyimino)-N-phenyl-acetamide oxime in strain TA1535 in the absence of activation in the Salmonella/microsome test.
Rogers-Back
A M
AM
Microbiological Associates, Bethesda, MD 20816.
Lawlor
T E
TE
Cameron
T P
TP
Dunkel
V C
VC
D000818:Animals; D001711:Biotransformation; D006224:Cricetinae; D007940:Leukemia L5178 / Q000235:genetics / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests / Q000379:methods; D009363:Neoplasm Proteins / Q000235:genetics; D010091:Oximes / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D012486:Salmonella typhimurium / Q000187:drug effects*; D013937:Thymidine Kinase / Q000235:genetics; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000378:metabolism
D009363:Neoplasm Proteins; D010091:Oximes; D013937:Thymidine Kinase