title: The effect of indomethacin on the psychomotor function of patients with rheumatic diseases.
abstract: We have compared the effect of single and multiple doses of indomethacin and placebo on objective measurements of psychomotor impairment in patients. Following a single 50 mg dose (n = 8), indomethacin produced psychomotor disturbance in only those patients who had no recent history of NSAID exposure. After multiple doses of indomethacin (25 and 50 mg tid for 5 days), significant psychomotor impairment was observed. We conclude that other NSAIDs may induce cross-tolerance to the psychomotor effects of indomethacin. Tachyphylaxis may develop to the psychomotor disturbance caused by indomethacin.
authors.affiliation: Department of Medicine, University of Leeds, UK.
authors.forename: T
authors.initials: T
authors.lastname: Pullar
authors.forename: O
authors.initials: O
authors.lastname: Myall
authors.forename: J R
authors.initials: JR
authors.lastname: Haigh
authors.forename: J R
authors.initials: JR
authors.lastname: Lowe
authors.forename: J S
authors.initials: JS
authors.lastname: Dixon
authors.forename: H A
authors.initials: HA
authors.lastname: Bird
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy* / Q000503:physiopathology; D011597:Psychomotor Performance / Q000187:drug effects*
chemical_list: D007213:Indomethacin