title: Acetic acids bearing the 1-phenyl-1H-indazole nucleus with analgesic and antiinflammatory activity.
abstract: The synthesis of [(1-phenyl-1H-indazol-4-yl)oxy]acetic acid (IV), (1-phenyl-1H-indazol-4-yl)acetic acid (IX) and (1,5,6,7)tetrahydro-1-phenyl-4H-indazol-4-iminooxy)acetic acid (XIII) starting from 1,5,6,7-tetrahydro-1-phenyl-4H-indazol-4-one (I) is described. These compounds showed a good antiinflammatory activity in rats, and an analgesic activity in mice similar or comparable to that of indomethacin.
authors.affiliation: Istituto di Scienze Farmaceutiche, Università di Genova, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Mosti
authors.forename: G
authors.initials: G
authors.lastname: Menozzi
authors.forename: P
authors.initials: P
authors.lastname: Schenone
authors.forename: L
authors.initials: L
authors.lastname: Molinario
authors.forename: F
authors.initials: F
authors.lastname: Conte
authors.forename: C
authors.initials: C
authors.lastname: Montanario
authors.forename: E
authors.initials: E
authors.lastname: Marmoe
mesh_terms: D000085:Acetates / Q000032:analysis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007191:Indazoles / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis*; D051381:Rats
chemical_list: D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007191:Indazoles; D011720:Pyrazoles