title: Saccharomyces cerevisiae acquires resistance to 2-deoxyglucose at a very high frequency.
abstract: We have found that Saccharomyces cerevisiae acquires spontaneously increasing resistance to 2-deoxyglucose at a very high frequency. This finding allows the easy isolation of different types of resistant strains of interest for metabolic studies with 2-deoxyhexoses. On the other hand, it sounds a note of caution in the widespread use of 2-deoxyglucose as a selective agent for the isolation of yeast mutants with impaired hexose transport or phosphorylation systems.
authors.affiliation: Instituto de Investigaciones Biomédicas, Facultad de Medicina, Universidad Autónoma, Spain.
authors.forename: M F
authors.initials: MF
authors.lastname: Heredia
authors.forename: C F
authors.initials: CF
authors.lastname: Heredia
mesh_terms: D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics
chemical_list: D003837:Deoxy Sugars; D003847:Deoxyglucose