title: [Anaphylactic reaction to human insulin. Successful desensitization].
abstract: A 48-year-old woman with diabetes mellitus (type IIb) had to be treated with insulin because of poor blood-sugar control. Infiltrates at the sight of injection occurred with two different porcine insulin preparations, necessitating a switch to human insulin. After the third injection of the latter an anaphylactic reaction developed within minutes. During a pregnancy in 1968 the patient had briefly received bovine insulin. Tests now revealed an immediate-type allergy against all three available species insulins, which was successfully treated by hyposensitisation.
authors.affiliation: Medizinische Klinik und Poliklinik, Universität Tübingen sowie III.
authors.forename: C
authors.initials: C
authors.lastname: Wintermantel
authors.forename: N
authors.initials: N
authors.lastname: Fischer
authors.forename: P H
authors.initials: PH
authors.lastname: Müller
authors.forename: H G
authors.initials: HG
authors.lastname: Velcovsky
authors.forename: G
authors.initials: G
authors.lastname: Lischka
authors.forename: M
authors.initials: M
authors.lastname: Eggstein
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000517:prevention & control; D000818:Animals; D002417:Cattle; D003888:Desensitization, Immunologic; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007328:Insulin / Q000009:adverse effects* / Q000276:immunology; D007330:Insulin Antibodies / Q000032:analysis; D008875:Middle Aged; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000188:drug therapy; D013045:Species Specificity; D013552:Swine; D013997:Time Factors
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007328:Insulin; D007330:Insulin Antibodies
vernacular_title: Anaphylaktische Reaktion auf Humaninsulin. Erfolgreiche Hyposensibilisierung.