Burn and trauma associated proteinuria: the role of lipid peroxidation, renin and myoglobin.
Ten trauma patients and 13 burns patients were studied intensively for the first 36 h and subsequent 6 days post injury in order to investigate the mechanism of trauma and burn associated proteinuria. Burns patient's initial maximum proteinuria occurred between 4 and 8 h post injury, whilst trauma patients showed greatest proteinuria within 4 h. In both groups coexisting myoglobinuria or marked elevation of serum renin activity was not found during the first 36 h. Following admission serum lipid peroxides rose in burns patients reaching a maximum between 2 and 8 h following injury, after which levels fell rapidly; in contrast trauma patient's values were initially within normal limits, but rose sharply after 12 h with peaks occurring between 16 h and 7 days post injury. Some patients within both groups showed a recurrent protein leak 2 to 5 days post injury. The data suggest that myoglobinuria or raised renin levels do not play an important role in trauma associated proteinuria.
Gosling
P
P
Biochemistry Department, Selly Oak Hospital, Birmingham, UK.
Sutcliffe
A J
AJ
Cooper
M A
MA
Jones
A F
AF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000209:etiology; D002056:Burns / Q000150:complications*; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008054:Lipid Peroxides / Q000097:blood / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000502:physiology*; D009212:Myoglobinuria / Q000209:etiology; D011507:Proteinuria / Q000378:metabolism* / Q000652:urine; D012083:Renin / Q000097:blood / Q000502:physiology*; D013858:Thiobarbiturates / Q000652:urine; D013997:Time Factors; D014947:Wounds and Injuries / Q000150:complications* / Q000378:metabolism
D008054:Lipid Peroxides; D009211:Myoglobin; D013858:Thiobarbiturates; D003404:Creatinine; D012083:Renin