[Reactivity of the blood phagocytes in patients with chronic bronchitis].
Bactericidal and migration activity of neutrophils was investigated in 53 patients with chronic bronchitis by means of a spontaneous and induced (6 stimulators) NBT-test and in 18 patients by means of skin fenestrae. A spontaneous NBT-test (sNBT-test) was shown to reflect the activity of an inflammatory bronchial process and to decrease by the end of therapy indicating complete remission. A stimulation index was in reverse correlation with sNBT-test indices. Response of neutrophils to various stimuli leveled down with an increase in sNBT-test indices. In an inflammatory bronchial process inhibition of neutrophil migration into a zone of inflammation was noted, particularly in patients with lingering exacerbation. Dependence of a stimulating effect on a sNBT-test value and disorder of neutrophil migration activity should be taken into account in administration of one or another immunostimulator.
Sidorova
L D
LD
Maianskiĭ
D N
DN
Kuznetsov
P O
PO
Rassanov
S P
SP
D000276:Adjuvants, Immunologic; D000328:Adult; D001991:Bronchitis / Q000276:immunology*; D002465:Cell Movement / Q000187:drug effects; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D009580:Nitroblue Tetrazolium; D010586:Phagocytes / Q000187:drug effects / Q000276:immunology*; D012884:Skin Window Technique
D000276:Adjuvants, Immunologic; D009580:Nitroblue Tetrazolium
Reaktivnost' fagotsitov krovi u bol'nykh khronicheskim bronkhitom.