Incidence of pancreatic tumors and tumor precursors in Sprague-Dawley rats after administration of olive oil.
We studied the pancreata of 280 (140 males and 140 females) olive-oil-treated and 240 (120 males and 120 females) untreated Sprague-Dawley rats of the breed used at the BT Experimental Unit of the Bologna Institute of Oncology. Extra-virgin olive oil was administered by stomach tube, once daily, for 4-5 days weekly, for 2 years. The animals were kept under observation for as long as 130 weeks. Only a borderline increase in acinar cell adenomas and adenocarcinomas was observed. We found no increase in endocrine oncologic lesions.
Perino
G
G
Institute of Oncology F. Addarii, Bologna, Italy.
Conti
B
B
Ciliberti
A
A
Maltoni
C
C
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology; D000236:Adenoma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D005260:Female; D008297:Male; D000069463:Olive Oil; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D010938:Plant Oils / Q000633:toxicity*; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D000069463:Olive Oil; D010938:Plant Oils