title: Radiation therapy and conservation surgery for primary and recurrent carcinoma of the vulva: report of 40 patients and a review of the literature.
abstract: Forty patients with histologically confirmed primary or recurrent vulvar carcinoma were treated with radiation therapy for loco-regional disease. Nineteen of the patients with primary tumors received postoperative radiotherapy (5000 cGy in 6 weeks). Fifteen of the 19 exhibited local tumor control. Five patients with Stage III or IV disease were managed with radiotherapy alone. Four had a complete response with two currently NED. Two patients who received preoperative radiotherapy with local excision are also currently free of disease. The 4-year NED survival for the study population is 100%, 28%, 50%, 0% and 10% for Stage I, II, III, IV and recurrent tumors respectively. The poor results obtained in Stage II tumors is likely due to selection criteria since four of seven patients developed distant metastases. Two of the 14 patients treated for recurrent disease remain NED after local excision of their tumors prior to irradiation. Even though the number of patients is small no dose response for subclinical disease could be found between 4500 and 7000 cGy. Treatment morbidity was acceptable with two patients developing severe long-term complications requiring surgical intervention.
authors.affiliation: Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: W M
authors.initials: WM
authors.lastname: Pao
authors.forename: C A
authors.initials: CA
authors.lastname: Perez
authors.forename: R R
authors.initials: RR
authors.lastname: Kuske
authors.forename: G M
authors.initials: GM
authors.lastname: Sommers
authors.forename: H M
authors.initials: HM
authors.lastname: Camel
authors.forename: A E
authors.initials: AE
authors.lastname: Galakatos
mesh_terms: D001918:Brachytherapy; D002277:Carcinoma / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D011182:Postoperative Care; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D014844:Vulva / Q000601:surgery; D014846:Vulvar Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery