Influence of joint inflammation on chondrocyte function.
Chondrocyte metabolism changes dramatically during joint inflammation. This overview summarizes the potential mechanisms underlying cartilage destruction in experimental arthritis models and provides arguments for a role for various inflammatory mediators. The contributions of both proteoglycan breakdown and impairment of chondrocyte function are discussed.
van den Berg
W B
WB
Department of Rheumatology, University Hospital St Radboud, Nijmegen, The Netherlands.
D000818:Animals; D000941:Antigens / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D002356:Cartilage / Q000187:drug effects / Q000473:pathology* / Q000502:physiology; D004195:Disease Models, Animal; D051379:Mice
D000941:Antigens