Immunohistochemical studies on local antitumor effects of streptococcal immunopotentiator, OK-432, in human solid malignant tumors.
Immunocytochemical techniques were used to clarify the local inhibitory effects of a streptococcal immunopotentiator, OK-432, against solid malignant tumor growth. Natural killer (NK) cells and fibronectin were chosen as immunostaining markers to demonstrate the antitumor effects. Immunocytochemical staining was performed by the avidin-biotin-peroxidase complex method. These investigations demonstrated that (1) local administration of OK-432 seems to promote a marked induction of NK cells and fibroblasts around or entering into the cancerous lesions and (2) the cancer cell-killing effect of NK cells and the fibronectin-enriched stromal reaction augmented by the injection of OK-432 suggest at least the possibility of protection against neoplastic growth with invasion and the spread of distant or nodal metastases of solid carcinomas.
Sugenoya
A
A
Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Usuda
N
N
Adachi
W
W
Kaneko
G
G
Nagata
T
T
Iida
F
F
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology*; D000911:Antibodies, Monoclonal; D001688:Biological Products / Q000008:administration & dosage*; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009333:Neck; D010844:Picibanil / Q000008:administration & dosage* / Q000627:therapeutic use; D013964:Thyroid Neoplasms / Q000188:drug therapy / Q000473:pathology*
D000911:Antibodies, Monoclonal; D001688:Biological Products; D010844:Picibanil