Cytosolic calcium in platelet activation.
Experiments with permeabilised platelets, and with intact platelets loaded with fluorescent Ca2+-indicators, over the past several years have greatly extended our knowledge and understanding of cytosolic Ca2+ as a platelet activator and its interactions with other cytosolic regulators. This article outlines insights, gained from the use of the fluorescent dyes, into maintenance and restoration of basal [Ca2+]i, mechanisms of receptor-mediated Ca2+-mobilisation and quantitation of [Ca2+]i/response relations in intact human platelets.
Rink
T J
TJ
Smith Kline & French Research Ltd, The Frythe, Welwyn, Hertshire, England.
D001792:Blood Platelets / Q000378:metabolism / Q000502:physiology*; D002118:Calcium / Q000097:blood*; D003600:Cytosol / Q000378:metabolism*; D006801:Humans; D009994:Osmolar Concentration; D012146:Rest
D002118:Calcium