title: A 3-year clinical trial to compare efficacy of dentifrices containing 1.14% and 0.76% sodium monofluorophosphate.
abstract: A 3-yr daily supervised toothbrushing study with a double blind design was conducted to evaluate the anticaries effectiveness of a 1.14% sodium monofluorophosphate (MFP) dentifrice (1500 ppm F) compared to a 0.76% MFP dentifrice (1000 ppm F). This study began with nearly 4000 children, primarily aged 8-11, in grades 3-5, residing in a nonfluoridated community in Florida. A total of 2415 children completed 3 yr of the study, representing 61% of the children who began the study. The results indicate a statistically significant (P less than 0.001) anticaries benefit was derived over a 3-yr period from the use of the higher fluoride dentifrice (1500 ppm F) when compared to the positive control (1000 ppm F). Percent reductions in mean dental caries increments were 20.9%, 22.1%, 21.8%, 24.3%, and 35.2% for DMFT, DFT, DMFS, DFS, and DFS Interproximal, respectively.
authors.affiliation: Department of Community Dentistry, College of Dentistry, University of Florida, Gainesville.
authors.forename: A J
authors.initials: AJ
authors.lastname: Conti
authors.forename: S
authors.initials: S
authors.lastname: Lotzkar
authors.forename: R
authors.initials: R
authors.lastname: Daley
authors.forename: L
authors.initials: L
authors.lastname: Cancro
authors.forename: R G
authors.initials: RG
authors.lastname: Marks
authors.forename: D R
authors.initials: DR
authors.lastname: McNeal
mesh_terms: D000293:Adolescent; D002648:Child; D002986:Clinical Trials as Topic; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control*; D003802:Dentifrices; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D010710:Phosphates / Q000008:administration & dosage*; D014099:Toothbrushing
chemical_list: D003802:Dentifrices; D010710:Phosphates; C012980:fluorophosphate; D005459:Fluorides