title: Bacterial infections of the lower urinary tract treated with ciprofloxacin or cefalexin--a comparative study.
abstract: 30/30 patients with lower UTI were enrolled in a randomized study to compare ciprofloxacin (250 mg/b.i.d.) and cefalexin (1 g/t.i.d.). In addition, 59 patients with cefalexin-resistant bacterial strains were treated in an open study arm. Ciprofloxacin showed convincingly better clinical and bacteriological efficacy than cefalexin. Both antibiotics were well tolerated. Ciprofloxacin has proved to be superior to cefalexin in the treatment of lower UTI.
authors.affiliation: III Clinic of Internal Medicine, Academy of Medicine, Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Polubiec
authors.forename: H
authors.initials: H
authors.lastname: Weuta
authors.forename: K
authors.initials: K
authors.lastname: Stepka
authors.forename: K
authors.initials: K
authors.lastname: Ktos
authors.forename: R
authors.initials: R
authors.lastname: Strazynska
authors.forename: J
authors.initials: J
authors.lastname: Jórasz
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy*; D002506:Cephalexin / Q000008:administration & dosage / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D011897:Random Allocation; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D002939:Ciprofloxacin; D002506:Cephalexin