Total ischemic burden: effect of vasoactive agents.
Treatment of the total ischemic burden is dependent on adequate documentation of both painful and painless episodes of myocardial ischemia, an understanding of the pathophysiologic mechanisms involved, and knowledge of prognosis for affected patients. Because a vasoconstrictive component appears to be an important element in the genesis of many episodes of myocardial ischemia, those vasoactive drugs that produce increased flow in the coronary circulation should be clinically useful. Nitrates and calcium blockers--especially nifedipine--have been found to be particularly valuable in this regard in both experimental and clinical trials.
Cohn
P F
PF
Cardiology Division, State University of New York Health Sciences Center, Stony Brook 11794.
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology*; D006801:Humans; D010146:Pain / Q000503:physiopathology; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents