title: Effect of positive end-expiratory pressure on right ventricular performance. Importance of baseline right ventricular function.
abstract: Thirty-six patients with diverse baseline right ventricular function were evaluated during incremental positive end-expiratory pressure (PEEP) application. Right heart pressures, cardiac output, right ventricular ejection fractions, and ventricular volumes were obtained at each PEEP level. Right ventricular peak systolic pressure-end-systolic volume relations were analyzed as an index of contractile function. Patients with severely depressed baseline right ventricular ejection fractions (30 percent or less) had an increase in end-diastolic (270 +/- 74 to 391 +/- 76 ml, 0 to 20 cm water (H2O) PEEP, p less than 0.05) and end-systolic volumes (210 +/- 70 to 321 +/- 70 ml, 0 to 20 cm H2O PEEP, p less than 0.05). These patients also had a decline in estimated right ventricular contractile function at 20 cm H2O PEEP as estimated by the slope of systolic pressure-volume relations (0.12 to 0.04 mm Hg/ml, 0 to 15 and 15 to 20 cm H2O PEEP, respectively, p less than 0.05). Patients with normal (40 percent or more) or moderately depressed (31 to 40 percent) baseline right ventricular ejection fractions had no change in right ventricular volumes or estimated contractile function. Therefore, the effect of PEEP on right ventricular function differs depending on the baseline right ventricular ejection fraction.
authors.affiliation: Department of Internal Medicine (Cardiology Section), Yale University School of Medicine, New Haven, Connecticut 06510.
authors.forename: D S
authors.initials: DS
authors.lastname: Schulman
authors.forename: J W
authors.initials: JW
authors.lastname: Biondi
authors.forename: R A
authors.initials: RA
authors.lastname: Matthay
authors.forename: P G
authors.initials: PG
authors.lastname: Barash
authors.forename: B L
authors.initials: BL
authors.lastname: Zaret
authors.forename: R
authors.initials: R
authors.lastname: Soufer
mesh_terms: D000328:Adult; D000368:Aged; D002302:Cardiac Output; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D011175:Positive-Pressure Respiration; D013318:Stroke Volume