title: A single-blind randomised trial comparing adrenaline 1.0% with dipivalyl epinephrine (propine) 0.1% in the treatment of open-angle glaucoma and ocular hypertension.
abstract: The results of this single-blind randomised trial comparing adrenaline 1% with dipivalyl epinephrine (Propine) 0.1% confirm that both have a significant effect in lowering the intraocular pressure in patients with open-angle glaucoma and ocular hypertension, but it is generally insufficient to warrant their use as the first line medical treatment of these two conditions. There was no significant difference between the intraocular lowering effect of the two preparations, and 60% of patients receiving Propine and 66% of those receiving adrenaline noted side effects.
authors.affiliation: Manchester Royal Eye Hospital.
authors.forename: K B
authors.initials: KB
authors.lastname: Mills
authors.forename: N A
authors.initials: NA
authors.lastname: Jacobs
mesh_terms: D000368:Aged; D002986:Clinical Trials as Topic; D004837:Epinephrine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009798:Ocular Hypertension / Q000188:drug therapy*; D011897:Random Allocation
chemical_list: C015173:dipivefrin; D004837:Epinephrine