T-cell subsets in the cerebrospinal fluid and blood of patients with multiple sclerosis.
The absolute numbers and ratios of helper/inducer (T4) and cytotoxic/suppressor (T8) T-cells were determined in cerebrospinal fluid (CSF) and blood of patients with multiple sclerosis (MS) and various other neurologic diseases (OND). In patients with MS, the T4:T8 ratio was higher in both blood and CSF, and the increase was significantly greater in CSF than in blood. These findings were due to an increased proportion of T4-lymphocytes in the CSF and to a decreased proportion of T8-cells in blood. These results indicate the need for additional studies of CSF lymphocytes in patients with MS.
Kölmel
H W
HW
Department of Neurology, Klinikum Rudolf-Virchow, Standort Charlottenburg, Berlin, F.R.G.
Sudau
C
C
D006801:Humans; D008214:Lymphocytes / Q000145:classification; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000473:pathology; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid / Q000473:pathology; D013601:T-Lymphocytes / Q000032:analysis / Q000145:classification*