title: Ribavirin small-particle-aerosol treatment of influenza B virus infection.
abstract: In a randomized double-blind trial of aerosolized ribavirin for the treatment of influenza B virus infection, no significant difference was found in the febrile course or symptom score of the ribavirin-treated versus placebo-treated patients. The apparent lack of efficacy in this study as compared with that in previous studies is unexplained.
authors.affiliation: Clinical Virology Division, James N. Gamble Institute of Medical Research, Cincinnati, Ohio 45219.
authors.forename: D I
authors.initials: DI
authors.lastname: Bernstein
authors.forename: P D
authors.initials: PD
authors.lastname: Reuman
authors.forename: J R
authors.initials: JR
authors.lastname: Sherwood
authors.forename: E C
authors.initials: EC
authors.lastname: Young
authors.forename: G M
authors.initials: GM
authors.lastname: Schiff
mesh_terms: D000328:Adult; D000336:Aerosols; D001831:Body Temperature; D002986:Clinical Trials as Topic; D004196:Disease Outbreaks; D004311:Double-Blind Method; D006801:Humans; D009981:Influenza B virus / Q000254:growth & development; D007251:Influenza, Human / Q000188:drug therapy*; D011897:Random Allocation; D012254:Ribavirin / Q000008:administration & dosage / Q000627:therapeutic use*; D012263:Ribonucleosides / Q000627:therapeutic use*
chemical_list: D000336:Aerosols; D012263:Ribonucleosides; D012254:Ribavirin