title: Prostacyclin mediation of vasodilation following mesenteric traction.
abstract: Eight untreated patients (group I) and four patients who received ibuprofen preoperatively (group II) scheduled for elective abdominal aortic aneurysm repair were studied. Heart rate (HR); systolic, diastolic, and mean arterial pressure (MAP); systolic and diastolic pulmonary artery pressure; pulmonary capillary wedge pressure (PCWP); cardiac output (CO); and central venous pressure (CVP) were recorded pre-induction, before mesenteric traction, and 5, 15, and 30 min post-mesenteric traction. Plasma samples were obtained at these times for analysis of six-keto-prostaglandin F1 alpha (PGF1 alpha) concentration by radioimmunoassay. Group II patients received ibuprofen 12 mg/kg orally 1 1/2 h before surgery. Plasma samples from six group I patients and all group II patients taken 5 min after mesenteric traction were added to isolated helical strips of cat superior mesenteric arteries precontracted with norepinephrine (200 ng/ml) for analysis of reduction in developed force. In group I, abdominal mesenteric traction resulted in a significant decrease in MAP (P less than 0.03) and SVR (P less than 0.005) with an increase in CO (P less than 0.05) at 5 min post-mesenteric traction, which returned to mean pre-mesenteric traction values by 30 min and a significant increase in PGF1 alpha concentrations. There was a significant positive correlation between PGF1 alpha and CO (P less than 0.001) and a significant negative correlation between PGF1 alpha and SVR (P less than 0.01) at 5 min post-mesenteric traction.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
authors.forename: J L
authors.initials: JL
authors.lastname: Seltzer
authors.forename: M E
authors.initials: ME
authors.lastname: Goldberg
authors.forename: G E
authors.initials: GE
authors.lastname: Larijani
authors.forename: D E
authors.initials: DE
authors.lastname: Ritter
authors.forename: M A
authors.initials: MA
authors.lastname: Starsnic
authors.forename: G L
authors.initials: GL
authors.lastname: Stahl
authors.forename: A M
authors.initials: AM
authors.lastname: Lefer
mesh_terms: D000368:Aged; D000818:Animals; D002415:Cats; D011464:Epoprostenol / Q000502:physiology*; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology; D008643:Mesentery / Q000502:physiology*; D008875:Middle Aged; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D014143:Traction; D014664:Vasodilation / Q000187:drug effects
chemical_list: D011448:Prostaglandin Antagonists; D011464:Epoprostenol; D007052:Ibuprofen