[Comparative evaluation of the treatment of Sjögren's syndrome with anti-rheumatic preparations].
The paper is devoted to comparative assessment of combined therapy of prednisolone, chlorambucil, chloroquine phosphate and ibuprofen at small doses and its effect on clinicolaboratory signs of Sjogren's disease in 80 patients in the course of 1 and 5 years. Patients of the control group received only local therapy of the parotid glands. The results have demonstrated that combined therapy at small doses of prednisolone and chlorambucil (5 mg + 4 mg) is an effective method of treatment of the stomatological, ophthalmological and articular manifestations of SD and is also capable of preventing the systemic signs of disease. Combined therapy with chloroquine phosphate and ibuprofen neither influenced the clinicolaboratory signs of disease nor prevented disease progression with the development of systemic signs of diseases of various degrees. Disease progression was observed in 80% of patients receiving no basic drugs or receiving chloroquine phosphate+ibuprofen while in groups of patients receiving small doses of prednisolone and chloambucil disease progression was observed in 20% only.
Vasil'ev
V I
VI
Simonova
M V
MV
Safonova
T N
TN
Mach
E S
ES
D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002699:Chlorambucil / Q000008:administration & dosage; D002738:Chloroquine / Q000008:administration & dosage / Q000031:analogs & derivatives; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D012859:Sjogren's Syndrome / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D002699:Chlorambucil; C023676:chloroquine diphosphate; D002738:Chloroquine; D011239:Prednisolone; D007052:Ibuprofen
Sravnitel'naia otsenka lecheniia bolezni Shegrena protivo-revmaticheskimi preparatami.