title: The in vitro screening of methylated 4-oxypiperidine compounds for inhibition of protein synthesis in a rabbit reticulocyte cell-free translation system.
abstract: A variety of methylated 4-oxypiperidine derivatives were tested for their ability to inhibit protein synthesis in vitro. A direct correlation was found between the extent of methylation of these compounds and their inhibitory activity in a rabbit reticulocyte lysate cell-free translation system.
authors.affiliation: Laboratory of Toxicology, Moscow City Station for Sanitation and Epidemiology, USSR.
authors.forename: D A
authors.initials: DA
authors.lastname: Kuznetsov
authors.forename: N V
authors.initials: NV
authors.lastname: Zavijalov
authors.forename: G J
authors.initials: GJ
authors.lastname: Kelman
authors.forename: A V
authors.initials: AV
authors.lastname: Govorkov
mesh_terms: D000818:Animals; D003497:Cyclic N-Oxides / Q000494:pharmacology*; D066298:In Vitro Techniques; D008745:Methylation; D014176:Protein Biosynthesis / Q000187:drug effects*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D013113:Spin Labels
chemical_list: D003497:Cyclic N-Oxides; D011500:Protein Synthesis Inhibitors; D013113:Spin Labels; C001803:tempol