title: A combination of levobunolol and dipivefrin for the treatment of glaucoma.
abstract: This double-masked prospective study compared the ocular hypotensive efficacy and the safety of 0.5% and 1% levobunolol hydrochloride with 0.5% timolol maleate when each was administered topically twice daily in combination with 0.1% dipivefrin hydrochloride. Forty-three patients whose intraocular pressure was previously controlled by concomitant treatment with timolol and dipivefrin were randomly assigned to receive 0.5% or 1% levobunolol and 0.1% dipivefrin, or to continue to receive 0.5% timolol and 0.1% dipivefrin for three months. In the groups receiving levobunolol and dipivefrin concurrently, continued intraocular pressure control was achieved equal to that attained with timolol and dipivefrin before study entry. We concluded that concomitant treatment with levobunolol and dipivefrin is equal in both efficacy and safety to concomitant treatment with timolol and dipivefrin.
authors.affiliation: Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville 22908.
authors.forename: R C
authors.initials: RC
authors.lastname: Allen
authors.forename: A L
authors.initials: AL
authors.lastname: Robin
authors.forename: D
authors.initials: D
authors.lastname: Long
authors.forename: G D
authors.initials: GD
authors.lastname: Novack
authors.forename: J C
authors.initials: JC
authors.lastname: Lue
authors.forename: G
authors.initials: G
authors.lastname: Kaplan
mesh_terms: D004338:Drug Combinations; D004837:Epinephrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure; D002040:Levobunolol / Q000009:adverse effects / Q000627:therapeutic use*; D009898:Optic Disk / Q000473:pathology; D012894:Sleep Stages / Q000187:drug effects; D013999:Timolol / Q000627:therapeutic use; D014794:Visual Fields
chemical_list: D004338:Drug Combinations; D013999:Timolol; C015173:dipivefrin; D002040:Levobunolol; D004837:Epinephrine