Is serum creatinine a reliable expression of an adequate cyclosporine immunosuppression?
In 13 renal transplant patients with an excellent graft function, but concomitant abnormal T6 CsA plasma levels (CsA plasma level, 6 hours after oral administration of the drug), dose adjustments of CsA were performed until a normal T6 was achieved. A significant decrease of serum creatinine values was obtained after dose modification. Prophylactic monitoring of CsA immunosuppression by T6 could be a means of avoiding nephrotoxicity or undertreatment in patients with acceptable serum creatinine levels and unsuspected drug related renal dysfunction.
Cantarovich
F
F
Nephrology Clinic, Hospital Edouard Herriot, Lyon, France.
Cantarovich
D
D
Suso
E
E
Lefrançois
N
N
Touraine
J L
JL
Traeger
J
J
D000328:Adult; D003404:Creatinine / Q000097:blood*; D003524:Cyclosporins / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D013997:Time Factors
D003524:Cyclosporins; D003404:Creatinine