Severe combined immunodeficiency syndrome, tissue transplant, leukaemia, and Q fever.
A child born with severe combined immunodeficiency, who was immunoreconstituted by a fetal liver and thymus transplant, developed acute lymphoblastic leukaemia in the donor cell line. During remission she contracted acute Q fever, which gave rise to unexpected complications. Early treatment of the Q fever might have altered the subsequent events and prevented her death.
Loudon
M M
MM
Department of Child Health, University of Wales College of Medicine, Cardiff.
Thompson
E N
EN
D002648:Child; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000628:therapy*; D007945:Leukemia, Lymphoid / Q000209:etiology*; D016031:Liver Transplantation; D011183:Postoperative Complications; D011778:Q Fever / Q000209:etiology*; D013950:Thymus Gland / Q000637:transplantation*