title: Comparative metabolic effects of chronic ethanol intake and undernutrition in pregnant rats and their fetuses.
abstract: Female rats receiving ethanol in the drinking water before and during gestation (ET) were compared to pair-fed animals (PF) and normal controls (C) fed ad libitum. On the 21st day of gestation the maternal body and liver weight, blood glucose, and plasma protein concentrations were lower in ET and PF animals as compared to C. In contrast to C or PF mothers, ET-fed mothers had higher circulating beta-hydroxybutyrate and triacyglyceride levels and beta-hydroxy-butyrate/acetoacetate ratio. Liver triacylglycerides were increased whereas liver glycogen concentration was reduced in ET-fed animals. Only fetal body and liver weights and blood glucose were lower in both ET and PF than in C. Blood beta-hydroxybutyrate was increased and liver glycogen was decreased only in ET fetuses. There were no differences among the groups in fetal circulating beta-hydroxy-butyrate/acetoacetate ratio, plasma proteins, and triacylglycerides or liver triacyglyceride content. Results indicate that certain changes in ET mothers are specifically produced by the ethanol intake rather than undernutrition. Further, metabolic changes occurring in the fetus are influenced by the ethanol effects in the mother and these actions may be added to those directly produced by the ethanol crossing the placenta. However, the collaterals were three times more likely to report more drinking days than the patients; 40.4% (86/213) of the cohabiting contacts reported more drinking days compared to 12.7% (27/213) of the patients reporting more drinking days (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Departament de Bioquimica y Fisiologia, Universitat de Barcelona, Spain.
authors.forename: X
authors.initials: X
authors.lastname: Testar
authors.forename: M
authors.initials: M
authors.lastname: Llobera
authors.forename: E
authors.initials: E
authors.lastname: Herrera
mesh_terms: D020155:3-Hydroxybutyric Acid; D000437:Alcoholism / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000378:metabolism* / Q000473:pathology; D006885:Hydroxybutyrates / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008112:Liver Glycogen / Q000378:metabolism; D009748:Nutrition Disorders / Q000209:etiology / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism* / Q000473:pathology; D011270:Pregnancy, Animal / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism
chemical_list: D001798:Blood Proteins; D006885:Hydroxybutyrates; D008112:Liver Glycogen; D014280:Triglycerides; D020155:3-Hydroxybutyric Acid