Generation of homozygosity at the c-Ha-ras-1 locus on chromosome 11p in an adrenal adenoma from an adult with Wiedemann-Beckwith syndrome.
Generation of homozygosity for the human c-Ha-ras-1 locus on the short arm of chromosome #11 (11p) has been demonstrated for an adrenal adenoma from an adult with Wiedemann-Beckwith syndrome (WBS). This is the first demonstration of loss of somatic heterozygosity for a locus on 11p in an adrenal neoplasm and is the first instance where a tumor of any type, from a patient with WBS, shows loss of heterozygosity in this region of the genome. Generation of homozygosity in an adenoma, rather than a carcinoma, demonstrates that this mechanism is an early event in tumorigenesis rather than a late event associated with tumor progression.
Hayward
N K
NK
Queensland Institute of Medical Research, Brisbane, Australia.
Little
M H
MH
Mortimer
R H
RH
Clouston
W M
WM
Smith
P J
PJ
D000236:Adenoma / Q000150:complications / Q000235:genetics*; D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000235:genetics*; D001506:Beckwith-Wiedemann Syndrome / Q000150:complications / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D005260:Female; D011905:Genes, ras; D005819:Genetic Markers; D006720:Homozygote; D006801:Humans; D008875:Middle Aged; D011519:Proto-Oncogenes
D005819:Genetic Markers