title: Large scale production of the vertebrate infective stage (L3) of Onchocerca volvulus (Filarioidea: Onchocercidae).
abstract: Laboratory-derived Simulium yahense and S. sanctipauli females were used to produce large numbers of Onchocerca volvulus infective stage larvae (L3) for use in assessing the possible chemoprophylactic potential of ivermectin in the chimpanzee model. Engorgement rates and subsequent post-prandial survival were correlated with the time at which adult flies were offered a carbohydrate source following emergence and the age of flies that fed on microfiladermic volunteers.
authors.affiliation: Department of Entomology, Cornell University, Ithaca, New York 14853-0999.
authors.forename: E W
authors.initials: EW
authors.lastname: Cupp
authors.forename: M J
authors.initials: MJ
authors.lastname: Bernardo
authors.forename: A E
authors.initials: AE
authors.lastname: Kiszewski
authors.forename: M
authors.initials: M
authors.lastname: Trpis
authors.forename: H R
authors.initials: HR
authors.lastname: Taylor
mesh_terms: D000818:Animals; D015331:Cohort Studies; D004195:Disease Models, Animal; D005260:Female; D007303:Insect Vectors / Q000469:parasitology*; D009854:Onchocerca / Q000254:growth & development*; D009855:Onchocerciasis / Q000469:parasitology*; D002679:Pan troglodytes; D012843:Simuliidae / Q000469:parasitology*