Polyalkylcyanoacrylates as colloidal drug carriers.
A considerable amount of energy has been spent in creating new colloidal drug delivery systems that are acceptable for general systemic use. Among these new systems, nanoparticles made with biodegradable polymers are gaining more and more interest. The aim of this paper is to describe the preparation and characterization of these nanoparticles and their in vivo behavior and to show the possibilities of using them in various fields of human medicine. The interaction of polyalkylcyanoacrylate nanoparticles with cells in culture is also discussed, as well as the possibility of improving the specificity of the carrier by coating it with monoclonal antibodies.
Couvreur
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CNRS, 1218, Faculté de Pharmacie, Université de Paris XI, Chatenay-Malabry, France.
D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D003102:Colloids; D003487:Cyanoacrylates / Q000008:administration & dosage*; D004337:Drug Carriers; D007328:Insulin / Q000008:administration & dosage; D011108:Polymers / Q000008:administration & dosage
D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D003102:Colloids; D003487:Cyanoacrylates; D004337:Drug Carriers; D007328:Insulin; D011108:Polymers