Experience with thymopentin in the treatment of periarthritis humeroscapularis, tendinitis, and gonarthrosis by local infiltration.
A total of 122 patients with periarthritis humeroscapularis, tendinitis, and gonarthrosis were accepted into a controlled, randomized double-blind study; of these patients, 61 subjects were administered local infiltrations of thymopentin (Timunox) 1 ml (50 mg) plus lidocaine 1 ml (2%), once a week for a period of 5 weeks. 61 subjects were during the same time treated with methylprednisolone depot 1 ml (40 mg) plus lidocaine 1 ml (2%). Demographic and clinical parameters were comparable in both groups. Intergroup comparison on completion of the therapy with regard to the criteria "pain at rest", "pain on pressure", "disability of articulation", and "pain relief" revealed statistically significant superiority of thymopentin. No unexpected drug experiences were observed in this double-blind study.
Pipino
F
F
1st Clinic of Orthopedics, University of Bari, Italy.
Vittore
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001168:Arthritis / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy; D010446:Peptide Fragments / Q000627:therapeutic use*; D010489:Periarthritis / Q000188:drug therapy* / Q000503:physiopathology; D052256:Tendinopathy / Q000188:drug therapy* / Q000503:physiopathology; D016305:Thymopentin; D013946:Thymopoietins / Q000627:therapeutic use*; D013951:Thymus Hormones / Q000627:therapeutic use*
D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; D016305:Thymopentin; D008775:Methylprednisolone