Anti-L3T4 monoclonal antibodies prolong survival of Ia-antigen disparate skin allografts.
Administration of monoclonal antibodies against L3T4 determinant significantly prolongs survival of Ia antigen-disparate skin allografts in mice. On the contrary, anti-Lyt-2 monoclonal antibodies had no suppressive effect on the rejection of skin allografts in the same model. These findings are different from the previous observations made in the strain combinations with disparities only in the class I antigens, in which anti-Lyt-2, but not anti-L3T4, antibodies were effective in suppression of allotransplantation reactions, and show that different cell populations are responsible for rejection of skin allografts disparate in class I or class II antigens.
Holán
V
V
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D006085:Graft Survival; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D051379:Mice; D008815:Mice, Inbred Strains; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II