Agnathia, holoprosencephaly, and situs inversus: report of a case.
We present the first documented case of agnathia-holoprosencephaly (an uncommon form of craniofacial anomaly) associated with situs inversus. This case may represent the concordance of multiple field complex anomalies, but the possibility of a major midline malformation (situs inversus) caused by a timed insult (environmental or genetic) which affects multiple structures and occurs concurrently with a major field defect during early embryogenesis cannot be excluded.
Leech
R W
RW
Department of Pathology, University of Oklahoma College of Medicine, Oklahoma City 73190.
Bowlby
L S
LS
Brumback
R A
RA
Schaefer
G B
GB
D000015:Abnormalities, Multiple; D005147:Facial Bones / Q000002:abnormalities*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012886:Skull / Q000002:abnormalities*