title: Managing trichomonal vaginitis refractory to conventional treatment with metronidazole.
abstract: Three patients with vulvovaginitis caused by Trichomonas vaginalis, which was refractory to conventional treatment with metronidazole are described. The T vaginalis strain isolated from one patient was resistant to metronidazole (minimum inhibitory concentration (MIC) more than 100 mg/l) under aerobic conditions, although under anaerobic conditions it was as susceptible as a normal reference strain. The effect of the concomitant use of other medication and the influence of other vaginal pathogens on the efficacy of metronidazole are highlighted.
authors.affiliation: Department of Genitourinary Medicine, Royal Hospital, Liverpool.
authors.forename: I H
authors.initials: IH
authors.lastname: Ahmed-Jushuf
authors.forename: A E
authors.initials: AE
authors.lastname: Murray
authors.forename: J
authors.initials: J
authors.lastname: McKeown
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use; D019980:Amoxicillin-Potassium Clavulanate Combination; D000818:Animals; D002969:Clavulanic Acids / Q000627:therapeutic use; D002985:Clinical Protocols; D004334:Drug Administration Schedule; D004338:Drug Combinations / Q000627:therapeutic use; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D013290:Streptococcal Infections / Q000150:complications; D013292:Streptococcus agalactiae; D014247:Trichomonas Vaginitis / Q000150:complications / Q000188:drug therapy*; D014246:Trichomonas vaginalis / Q000187:drug effects
chemical_list: D002969:Clavulanic Acids; D004338:Drug Combinations; D008795:Metronidazole; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin