IgE-dependent killing of Schistosoma mansoni schistosomula by human platelets: modulation by T cell products.
The in vitro stimulation of T lymphocytes is known to induce the release of factors that possess distinct biological activities. In the present report, we describe the presence, in supernatants of Schistosoma mansoni antigen stimulated T cells from S. mansoni infected patients, of a factor able to inhibit the IgE-dependent platelet cytotoxicity of the same individuals toward the young larvae of S. mansoni.
Pancré
V
V
Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France.
Cesbron
J Y
JY
Joseph
M
M
Barbier
M
M
Capron
A
A
Auriault
C
C
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D001792:Blood Platelets / Q000276:immunology*; D002474:Cell-Free System; D005434:Flow Cytometry; D006801:Humans; D007073:Immunoglobulin E / Q000502:physiology*; D007814:Larva / Q000276:immunology; D008213:Lymphocyte Activation; D012550:Schistosoma mansoni / Q000254:growth & development / Q000276:immunology*; D013491:Suppressor Factors, Immunologic / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*
D013491:Suppressor Factors, Immunologic; D007073:Immunoglobulin E