Vitamin D metabolites and bioactive parathyroid hormone levels during Spacelab 2.
The purpose of this study was to determine whether plasma levels of the vitamin D hormone and parathyroid hormone (PTH), two potent activators of bone remodeling sites, were altered in four astronauts during the 8-day (d) Spacelab 2 mission (SL2). Increased circulating levels of either hormone could change calcium homeostasis and bone cell activity and, thus, contribute to bone loss in crewmembers in space. The vitamin D hormone was elevated in all astronauts at the end of the first inflight day but returned to normal by the seventh day. Biologically active PTH tended to be normal throughout the mission. Both hormones were within the normal range by the end of the 8-d flight of this SL2 crew. Plasma levels of 25OHD, 24,25(OH)2D, calcium, phosphorus, and albumin were essentially normal during the mission.
Morey-Holton
E R
ER
Space Biology Branch, NASA-Ames Research Center, Moffett Field, CA 94035.
Schnoes
H K
HK
DeLuca
H F
HF
Phelps
M E
ME
Klein
R F
RF
Nissenson
R H
RH
Arnaud
C D
CD
D015650:24,25-Dihydroxyvitamin D 3; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood; D004100:Dihydroxycholecalciferols / Q000097:blood; D006706:Homeostasis; D006801:Humans; D010281:Parathyroid Hormone / Q000097:blood*; D012016:Reference Values; D013026:Space Flight; D014807:Vitamin D / Q000097:blood*
D004100:Dihydroxycholecalciferols; D010281:Parathyroid Hormone; D014807:Vitamin D; D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol; D002112:Calcifediol