title: The N-methyl-D-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils.
abstract: N-Methyl-D-aspartate (NMDA) antagonists reduce ischemic brain damage and associated hypermotility. Two potent, selective and competitive NMDA antagonists, cis-4-(phosphonomethyl)-2-piperidine-carboxylic acid (CGS 19755) and 4-(3-phosphonopropyl)-2-piperazine-carboxylic acid (CPP), were characterized in the gerbil ischemia model with respect to dose-response and time course effects. Both drugs were effective in reducing ischemia-induced hippocampal brain damage as well as hypermotility. In this model, CGS 19755 was more potent than CPP, and had protective effects when given after longer delays between ischemia and drug administration.
authors.affiliation: Research Department, Ciba-Geigy Corp., Summit, NJ 07901.
authors.forename: C A
authors.initials: CA
authors.lastname: Boast
authors.forename: S C
authors.initials: SC
authors.lastname: Gerhardt
authors.forename: G
authors.initials: G
authors.lastname: Pastor
authors.forename: J
authors.initials: J
authors.lastname: Lehmann
authors.forename: P E
authors.initials: PE
authors.lastname: Etienne
authors.forename: J M
authors.initials: JM
authors.lastname: Liebman
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D001921:Brain / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D005260:Female; D005849:Gerbillinae; D006624:Hippocampus / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D009043:Motor Activity / Q000187:drug effects*; D016202:N-Methylaspartate; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010875:Pipecolic Acids; D010879:Piperazines / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*
chemical_list: D010875:Pipecolic Acids; D010879:Piperazines; D010880:Piperidines; D001224:Aspartic Acid; C053672:selfotel; D016202:N-Methylaspartate; C050592:3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid