High salt diet decreases longevity in the spontaneously hypertensive rat.
1. Blood pressure, body weight and mortality rate were examined in female spontaneously hypertensive rats (SHR) of the Okamoto strain maintained on a lifelong high (5% NaCl w/w) or low (0.1% NaCl w/w) salt diet. 2. A high salt diet increased mortality and decreased body weight in SHR, but failed to significantly alter blood pressure up to 24 months of age. 3. Hence, a low salt diet does not appear to be a long-term risk factor and may protect the SHR from cardiovascular accidents.
Di Nicolantonio
R
R
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.
Silvapulle
M J
MJ
Spargo
S
S
Morgan
T O
TO
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006973:Hypertension / Q000503:physiopathology*; D008136:Longevity; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D012307:Risk Factors; D012982:Sodium, Dietary / Q000494:pharmacology*
D012982:Sodium, Dietary