IgA dermatosis in an adult Chinese population. A 10-year study of linear IgA and dermatitis herpetiformis in Singapore.
During a 10-year period (1976-1985), eight Chinese patients from a population of 2.5 million fulfilled the criteria for dermatitis herpetiformis and linear IgA bullous dermatosis (LABD). These rare diseases among Asians presented during the third decade of life with homogenous linear IgA deposits along the dermoepidermal junction in four of the eight cases. Three had classic granular deposits in the papillary dermis, while one was negative. There has been a remission in two of the patients. Dermatitis herpetiformis among the Chinese differs from experience elsewhere in that there was no associated gluten-sensitive enteropathy. The response to a very low-dose dapsone was excellent in most cases.
Ratnam
K V
KV
Department of Dermatology, Middle Road Hospital, Singapore.
D000328:Adult; D002681:China / Q000208:ethnology; D003622:Dapsone / Q000627:therapeutic use; D003874:Dermatitis Herpetiformis / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D012846:Singapore; D012867:Skin / Q000276:immunology* / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology
D007070:Immunoglobulin A; D003622:Dapsone; D011239:Prednisolone