Altered expression of lymphocyte Il-2 receptors in burned patients.
Impairment of T-cell function is a consistent observation in burned patients. Concomitant with this impairment is an increase in serum factors which inhibit interleukin-2-mediated T-cell functions. These factors are heat labile and do not behave like endotoxins. Nonetheless, treatment of burned patients with endotoxin-neutralizing regimens of polymyxin B reduces the levels of these factors, suggesting that they are generated in response to endotoxin exposure. In addition to factors which inhibit Il-2 responses burn serum contains increases of circulating soluble, cell-free Il-2 receptors. However, the level of Il-2R is not altered by polymyxin B treatment and does not appear to be a direct result of endotoxin exposure. These observations suggest that multiple causes contribute to T-cell impairment in burned patients.
Xiao
G X
GX
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Chopra
R K
RK
Adler
W H
WH
Munster
A
A
Winchurch
R A
RA
D000328:Adult; D002056:Burns / Q000188:drug therapy / Q000276:immunology*; D004731:Endotoxins / Q000097:blood; D006801:Humans; D008213:Lymphocyte Activation; D011112:Polymyxin B / Q000627:therapeutic use; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D013601:T-Lymphocytes / Q000276:immunology*
D004731:Endotoxins; D015375:Receptors, Interleukin-2; D011112:Polymyxin B