Microbiologic characteristics of unpreserved saline.
This study was designed to assess the microbiological risk associated with using unpreserved saline buffered with either borate or phosphate salts. The results indicate that borate buffer has measurable antimicrobial activity and can control some microbiological contamination. However, phosphate-buffered saline can become easily contaminated and usually promotes growth or maintains viability of adventitious contaminants.
Houlsby
R D
RD
CooperVision Ophthalmic Products, San Jose, CA 95134.
Ghajar
M
M
Chavez
G
G
D000818:Animals; D001230:Aspergillus / Q000187:drug effects / Q000254:growth & development; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D001888:Boric Acids / Q000494:pharmacology*; D002021:Buffers / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D007552:Isotonic Solutions; D010710:Phosphates / Q000494:pharmacology*; D011549:Pseudomonas / Q000187:drug effects / Q000254:growth & development; D012706:Serratia marcescens / Q000187:drug effects / Q000254:growth & development; D012965:Sodium Chloride / Q000494:pharmacology*
D001888:Boric Acids; D002021:Buffers; D007552:Isotonic Solutions; D010710:Phosphates; D012965:Sodium Chloride