Investigations into the effect on rats of volatile organic compounds released from the set of building and finishing materials.
White, male Wistar rats were exposed continuously in chamber during 3 months on volatile organic compounds emitted from set of building and finishing materials used in living areas on ship. The air contamination was checked. The following tests for determination of combined toxic effects were performed: functional activity, the body and organ weights, basic hematological determinations, serum enzyme activity (GOT, GPT, AP, LAP, LDH), serum concentrations of protein, urea, creatinine, bilirubin, lipids, cholesterol, triglycerides, and in the liver mitochondria Mg+2(-)-ATPase, concentration of cholesterol, phospholipids, and liver function after loading with benzoate. After 3 months of the exposure we observed changes in AP and LDH activities, and decrease of the concentration of serum triglycerides.
Wiglusz
R
R
Department of Toxicology, Institute of Maritime and Tropical Medicine, Gdynia.
Jarnuszkiewicz
I
I
Delag
G
G
Dubicka
J
J
Gałuszko
E
E
Wolska
L
L
Winnicka
A
A
Hać
E
E
D000085:Acetates / Q000009:adverse effects; D000397:Air Pollution / Q000009:adverse effects; D000818:Animals; D003252:Construction Materials / Q000009:adverse effects*; D004781:Environmental Exposure; D005557:Formaldehyde / Q000009:adverse effects; D015386:Hazardous Substances / Q000009:adverse effects; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014050:Toluene / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood
D000085:Acetates; D015386:Hazardous Substances; D014280:Triglycerides; D005557:Formaldehyde; D014050:Toluene; C007650:ethyl acetate; D007770:L-Lactate Dehydrogenase