title: The efficacy results and safety profile of imipenem/cilastatin from the clinical research trials.
abstract: Imipenem/cilastatin is highly effective for infections in many body sites against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. During therapy, development of resistance is uncommon except in the case of Pseudomonas aeruginosa in which the incidence appears similar to that for other beta-lactam antibiotics. There appears to be a very low probability of cross-resistance. The clinical and laboratory adverse reactions are similar in type to those for other beta-lactam antibiotics. The frequency of colonization and superinfection during treatment with imipenem/cilastatin has been comparable to other antibiotics in comparative trials and to literature reports for other antibiotics for noncomparative trials.
authors.affiliation: Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486.
authors.forename: G B
authors.initials: GB
authors.lastname: Calandra
authors.forename: F M
authors.initials: FM
authors.lastname: Ricci
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: K R
authors.initials: KR
authors.lastname: Brown
mesh_terms: D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D015377:Cilastatin; D003521:Cyclopropanes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D015378:Imipenem; D013845:Thienamycins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D003521:Cyclopropanes; D013845:Thienamycins; D015377:Cilastatin; D015378:Imipenem