title: Glutamate dehydrogenase: biochemical and clinical aspects of an interesting enzyme.
abstract: The molecular properties and possible metabolic functions of glutamate dehydrogenase (GLDH-EC 1.4.1.3) are described. The distribution of this enzyme in the body and particularly in the liver are outlined. The significance of these properties for GLDH release into the extracellular space, for the distribution and elimination of the enzyme and, foremost, for the assay of GLDH as a diagnostic indicator of hepatic and biliary disease are shown. Analytical methods are reviewed.
authors.affiliation: Abteilung Gastroenterologie und Hepatologie, Zentrum Innere Medizin und Dermatologie, Medizinische Hochschule Hannover (FRG).
authors.forename: E S
authors.initials: ES
authors.lastname: Schmidt
authors.forename: F W
authors.initials: FW
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D001660:Biliary Tract Diseases / Q000175:diagnosis; D005969:Glutamate Dehydrogenase / Q000032:analysis*; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis
chemical_list: D005969:Glutamate Dehydrogenase