title: Synthesis of interleukin-1-like activity by normal rat chondrocytes in culture.
abstract: Chondrocytes prepared from the articular cartilage of young rats synthesize and secrete an interleukin-1-like activity into the medium. The physical and biochemical properties of this IL-1-like activity are similar to macrophage-derived IL-1. Immunological studies suggest that this activity is related to IL-1 alpha. Isolated chondrocytes and those grown in culture can express Ia.
authors.affiliation: Department of Inflammation and Immunology, American Cyanamid Company, Lederle Laboratories Division, Pearl River, New York 10965.
authors.forename: N C
authors.initials: NC
authors.lastname: Rath
authors.forename: A L
authors.initials: AL
authors.lastname: Oronsky
authors.forename: S S
authors.initials: SS
authors.lastname: Kerwar
mesh_terms: D000818:Animals; D001681:Biological Assay; D002358:Cartilage, Articular / Q000166:cytology / Q000378:metabolism*; D002478:Cells, Cultured; D007158:Immunologic Techniques; D007375:Interleukin-1 / Q000096:biosynthesis*; D051381:Rats; D013997:Time Factors
chemical_list: D007375:Interleukin-1