The acute renal haemodynamic and endocrine response to felodipine in normal man.
Felodipine (0.075 mg/kg p.o.), a calcium antagonist, was given to 9 male volunteers, with and without indomethacin pretreatment. Diuresis and natriuresis occurred after felodipine without significant change in effective renal plasma flow or glomerular filtration rate. There was no significant change in urinary 6 keto PGF 1 alpha or urinary kallikrein excretion and indomethacin did not inhibit the natriuretic or diuretic response to felodipine. The felodipine induced diuresis and natriuresis appears most likely to be mediated by an action of the drug on renal tubules.
Jenkins
D A
DA
Department of Medicine, University of Edinburgh, Royal Infirmary, U.K.
Craig
K
K
Cumming
A D
AD
Watson
M L
ML
D000328:Adult; D004231:Diuresis / Q000187:drug effects; D015736:Felodipine; D006801:Humans; D007610:Kallikreins / Q000502:physiology / Q000652:urine; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D009568:Nitrendipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011453:Prostaglandins / Q000502:physiology / Q000652:urine; D012079:Renal Circulation / Q000187:drug effects*; D012083:Renin / Q000502:physiology / Q000652:urine; D014665:Vasodilator Agents / Q000494:pharmacology*
D011453:Prostaglandins; D014665:Vasodilator Agents; D009568:Nitrendipine; D007610:Kallikreins; D012083:Renin; D015736:Felodipine