Effect of calcium blocking agent verapamil on blood pressure, ventricular contractility, parathyroid hormone, calcium and phosphorus in plasma, catecholamines, corticosterone and plasma renin activity in spontaneously hypertensive rats.
In four-month-old spontaneously hypertensive rats (SHR) the effect of a calcium blocking agent verapamil on blood pressure, ventricular contractility indices, parathyroid hormone (PTH), plasma renin activity (PRA), plasma and adrenal corticosterone content and catecholamines in hypothalamus, myocardium and adrenal gland was evaluated. Calcium and phosphorus in plasma were also determined. Verapamil treatment resulted in a significant decrease in systolic and diastolic blood pressure and a reduction in maximum left ventricular pressure. Verapamil exerted a negative inotropic effect, evaluated by a decrease in dP/dt max and dP/dt neg. PRA was elevated, calcium tended to decrease, and no changes in PTH and phosphorus were found. The hypotensive effect of verapamil in SHR was accompanied by a decrease in plasma and adrenal corticosterone content, and a fall in catecholamine concentration in adrenal glands and myocardium.
Nicolov
N
N
Department of Pathophysiology, Research Medico-Biological Institute, Sofia, Bulgaria.
Todorova
M
M
Ilieva
T
T
Velkov
Z
Z
Lolov
R
R
Petkova
M
M
Ancov
V
V
Sheitanova
S
S
Tzoncheva
A
A
Grigorova
R
R
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000097:blood; D002395:Catecholamines / Q000097:blood; D003345:Corticosterone / Q000097:blood; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D051381:Rats; D011918:Rats, Inbred SHR; D012083:Renin / Q000097:blood; D014700:Verapamil / Q000097:blood / Q000494:pharmacology*
D002395:Catecholamines; D010281:Parathyroid Hormone; D010758:Phosphorus; D014700:Verapamil; D012083:Renin; D002118:Calcium; D003345:Corticosterone