Deafferentation pain in man.
Pains of various etiologies are described in so many overlapping ways that verbal descriptions alone do not permit a valid distinction between those pains associated with neurological injury (with or without sensory loss) and those associated with neurological compression. Nor does the fact of some sensory loss plus pain constitute a useful classification to determine either the mechanism of the pain or its treatment. Progress is more likely to ensue if we seek to characterize in detail each type of painful lesion. Evidence for these conclusions is drawn from cases of brachial plexus injury, trigeminal rhizotomy and tractotomy, postcordotomy dysesthesia and central pain treated by regional guanethidine block. Examples of the value of totally innovative approaches are drawn from the physics of elementary particles.
Sweet
W H
WH
Neurosurgical Service, Massachusetts General Hospital, Boston.
D000344:Afferent Pathways / Q000502:physiology; D003714:Denervation; D005260:Female; D006801:Humans; D008297:Male; D009475:Neurons, Afferent / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000503:physiopathology; D013116:Spinal Cord / Q000503:physiopathology* / Q000601:surgery