title: Interaction between cigarette smoke condensate and radiation for the induction of genotoxic effects in yeast.
abstract: Induction of gene conversion in diploid yeast strains BZ34 and D7 was investigated following exposure to cigarette smoke condensate (CSC) and gamma radiation. Cells treated with CSC for 1 h showed 5-10-fold increase in gene conversion over the background frequency. Log-phase cells were 2-3 times more sensitive compared to stationary-phase cells. Cells exposed to a combination of CSC and radiation suggested an additive response of the 2 agents, irrespective of the order of the 2 treatments.
authors.affiliation: Division of Radiological Protection, Bhabha Atomic Research Centre, Trombay, Bombay, India.
authors.forename: N S
authors.initials: NS
authors.lastname: Narayanan
authors.forename: B S
authors.initials: BS
authors.lastname: Rao
mesh_terms: D005720:Gamma Rays; D007700:Kinetics; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000254:growth & development / Q000528:radiation effects; D012906:Smoke
chemical_list: D012906:Smoke