Streptococcal cell-wall-induced arthritis in rats: an overview.
The author summarizes research performed by himself and his colleagues to study chronic erosive arthritis by means of injecting fragments of streptococcal cell walls into rats. By study of rat strains resistant and susceptible to various stages of the disease, as well as the effects of therapeutic drugs, information has been obtained on the pathogenesis of the synovitis and on the role of cellular and humoral factors in regulating inflammatory disease.
Wilder
R L
RL
Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892.
D000818:Animals; D001168:Arthritis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D002473:Cell Wall / Q000502:physiology; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D005260:Female; D051381:Rats; D013291:Streptococcus / Q000166:cytology*; D013583:Synovial Membrane / Q000473:pathology