Single dose comparison of torasemide and furosemide in patients with advanced renal failure.
In a comparative study on the fluid and electrolyte excretion of 90 patients with chronic renal failure (serum creatinine greater than or equal to 3.0 mg/dl) 100 and 200 mg torasemide (1-isopropyl-3- ([4-(3-methyl-phenylamino)pyridine]-3-sulfonyl)urea) vs. 100 and 200 mg furosemide were administered intravenously. A long-acting salidiuretic effect was demonstrated for torasemide. Torasemide can thus be categorized as a high-ceiling, long-acting diuretic. Tolerance of both diuretics was comparable.
Klütsch
K
K
Department of Internal Medicine, Kreiskrankenhaus Wetzlar, Mannheim, Fed. Rep. of Germany.
Grosswendt
J
J
Haecker
W
W
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002712:Chlorides / Q000097:blood; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000097:blood; D004232:Diuretics / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005665:Furosemide / Q000008:administration & dosage / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D011897:Random Allocation; D012964:Sodium / Q000097:blood; D013449:Sulfonamides / Q000008:administration & dosage / Q000627:therapeutic use*; D000077786:Torsemide
D002712:Chlorides; D004232:Diuretics; D013449:Sulfonamides; D005665:Furosemide; D012964:Sodium; D003404:Creatinine; D011188:Potassium; D000077786:Torsemide