Ring chromosomes in chronic myelogenous leukemia: an ominous finding.
Two cases of Philadelphia chromosome positive chronic myelogenous leukemia (CML) demonstrated ring chromosomes. The appearance of the ring coincided with evolution from the stable to the aggressive phase. A literature search yielded six other cases of ring chromosomes in CML; all were in or were entering the aggressive phase of the disease. Thus, as is the case with acute nonlymphocytic leukemia, in CML the finding of an acquired ring chromosome is associated with a poor prognosis.
Lewis
J P
JP
Department of Medicine, University of California, School of Medicine, Davis 95616.
Jenks
H
H
Walling
P
P
D000328:Adult; D002471:Cell Transformation, Neoplastic; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000473:pathology; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D015465:Leukemia, Myeloid, Accelerated Phase / Q000235:genetics / Q000473:pathology; D011379:Prognosis; D012303:Ring Chromosomes