Leukocytosis induced by microinjection of endogenous pyrogen or interleukin-1 into the preoptic and anterior hypothalamus.
We investigated the effect of microinjection of endogenous pyrogen or interleukin-1 (EP/IL-1) into 40 selected brain regions on the circulating leukocyte count in rabbits. The results show that injections into the rostral region of the hypothalamus, especially the preoptic and anterior hypothalamus, induce leukocytosis.
Morimoto
A
A
Department of Physiology, Yamaguchi University, School of Medicine, Japan.
Watanabe
T
T
Sakata
Y
Y
Murakami
N
N
D000818:Animals; D004731:Endotoxins / Q000494:pharmacology*; D007032:Hypothalamus, Anterior / Q000187:drug effects / Q000503:physiopathology*; D007375:Interleukin-1 / Q000494:pharmacology*; D007964:Leukocytosis / Q000139:chemically induced*; D008297:Male; D008845:Microinjections; D011301:Preoptic Area / Q000187:drug effects / Q000503:physiopathology*; D011817:Rabbits; D012485:Salmonella typhi
D004731:Endotoxins; D007375:Interleukin-1