title: Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis.
abstract: A regulatory cascade, initiated during the syncytial stage of embryogenesis, culminates in the striped pattern of engrailed gene expression at the cellular blastoderm stage. The early regulatory genes, for example the pair-rule genes, are expressed transiently and as their products decay a distinct regulatory programme involving segment polarity genes takes over. This late programme maintains and perhaps modifies the striped pattern of engrailed expression through interactions that may involve cell communication.
authors.affiliation: Department of Biochemistry and Biophysics, UCSF School of Medicine 94143-0448.
authors.forename: S
authors.initials: S
authors.lastname: DiNardo
authors.forename: E
authors.initials: E
authors.lastname: Sher
authors.forename: J
authors.initials: J
authors.lastname: Heemskerk-Jongens
authors.forename: J A
authors.initials: JA
authors.lastname: Kassis
authors.forename: P H
authors.initials: PH
authors.lastname: O'Farrell
mesh_terms: D000818:Animals; D002450:Cell Communication; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D005786:Gene Expression Regulation; D005809:Genes, Regulator; D012045:Regulatory Sequences, Nucleic Acid