title: Neurophysiological aspects of auditory hallucinations. 99mTc-(HMPAO)-SPECT investigations in patients with auditory hallucinations and normal controls--a preliminary report.
abstract: In a symptom-oriented study 17 patients suffering from chronic auditory hallucinations were investigated by means of 99mTc-HMPAO-SPECT and compared with healthy controls. The results confirm the relative frontal hypoactivity in junction with a relative hyperactivity in the basal ganglia and mesial limbic structures in both hemispheres found in a previous pilot study in auditorily hallucinating patients. Our results should fortify the symptom-oriented approach in psychiatric research.
authors.affiliation: Department of Psychiatry, University of Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Musalek
authors.forename: I
authors.initials: I
authors.lastname: Podreka
authors.forename: E
authors.initials: E
authors.lastname: Suess
authors.forename: D
authors.initials: D
authors.lastname: Nutzinger
authors.forename: V
authors.initials: V
authors.lastname: Passweg
authors.forename: R
authors.initials: R
authors.lastname: Strobl
authors.forename: H
authors.initials: H
authors.lastname: Walter
authors.forename: C
authors.initials: C
authors.lastname: Baumgartner
authors.forename: O M
authors.initials: OM
authors.lastname: Lesch
mesh_terms: D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D001479:Basal Ganglia / Q000098:blood supply; D001921:Brain / Q000098:blood supply*; D001931:Brain Mapping / Q000379:methods; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply; D006212:Hallucinations / Q000503:physiopathology*; D006624:Hippocampus / Q000098:blood supply; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D010091:Oximes; D011618:Psychotic Disorders / Q000503:physiopathology*; D012039:Regional Blood Flow; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime