Comparison of the in vitro cytotoxicity of cyclodisone with a series of structurally related analogues.
The in vitro cytotoxicity of a series of cyclic and linear sulfonate esters has been tested against the BE and HT-29 human colon carcinoma cell lines. Cyclodisone, a cyclic sulfonate ester, was found to be more toxic to the BE cell line when compared with the HT-29 cell line. In contrast, busulfan, a linear sulfonate ester, was equally toxic to both cell lines. Furthermore, alteration of the cyclodisone structure was found to produce marked differences in its cytotoxicity to these cell lines. These compounds would thus appear an excellent class of structures with which to produce new alkylating anti-cancer agents.
Gibson
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Laboratory of Pharmacology, AMC Cancer Research Center, Denver, CO 80214.
D000970:Antineoplastic Agents; D002277:Carcinoma; D002470:Cell Survival / Q000187:drug effects*; D003110:Colonic Neoplasms; D006801:Humans; D013329:Structure-Activity Relationship; D013846:Thiepins / Q000633:toxicity*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D013846:Thiepins; C048244:cyclodisone