title: The effects of bulk versus particulate polymethylmethacrylate on bone.
abstract: Twenty-one mature New Zealand white female rabbits were allocated into three groups of seven rabbits. Group I received a bolus of doughy Simplex polymethylmethacrylate (PMMA) cement injected into the proximal tibia through a drill hole. Group II received a preformed, cooled, bulk PMMA pellet. Group III had particulate PMMA powder implanted. The operated, but nonimplanted, left tibiae served as controls. Animals were killed after four months. Histologically, both Group I and Group II demonstrated a thin, fibrous tissue membrane at the implant interface. Particulate PMMA (Group III) stimulated a much thicker, florid, foreign body reaction composed of histiocytes and giant cells. The foreign body response to particulate acrylic cement was similar to that seen in failed cemented joint replacement arthroplasty in humans.
authors.affiliation: Stanford University Medical Center, Division of Orthopaedic Surgery, California 94305-5326.
authors.forename: S B
authors.initials: SB
authors.lastname: Goodman
authors.forename: V L
authors.initials: VL
authors.lastname: Fornasier
authors.forename: J
authors.initials: J
authors.lastname: Kei
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology; D008768:Methylmethacrylates / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D013977:Tibia / Q000187:drug effects / Q000601:surgery / Q000648:ultrastructure
chemical_list: D008768:Methylmethacrylates