Efficacy of defibrinogenation and steroid therapies on sudden deafness.
Effects of defibrinogenation therapy and steroid therapy for sudden deafness were compared by paired double-blind testing. The average hearing recovery for five frequencies (250 to 4000 Hz) was more than 30 dB; overall improvement rate was 57.3% (47/82) for the patients assigned to defibrinogenation therapy and 38.7% (31/80) for the patients assigned to steroid therapy. Thus, the former treatment resulted in significantly better hearing recovery.
Kubo
T
T
Department of Otolaryngology, Osaka University School of Medicine, Japan.
Matsunaga
T
T
Asai
H
H
Kawamoto
K
K
Kusakari
J
J
Nomura
Y
Y
Oda
M
M
Yanagita
N
N
Niwa
H
H
Uemura
T
T
D000284:Administration, Oral; D000328:Adult; D012103:Batroxobin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001623:Betamethasone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001809:Blood Viscosity; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D003639:Hearing Loss, Sudden / Q000097:blood / Q000628:therapy*; D006400:Hematocrit; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D012697:Serine Endopeptidases / Q000627:therapeutic use*
D005340:Fibrinogen; D001623:Betamethasone; D012103:Batroxobin; D012697:Serine Endopeptidases