title: Alprazolam in the treatment of cardiology patients with atypical chest pain and panic disorder.
abstract: Ten cardiology chest pain patients without clinical evidence of coronary artery disease and with panic disorder were enrolled in an open label trial of alprazolam. Two dropped out at week 3 because of excessive side effects. The eight study completers showed significant decreases in both Hamilton Anxiety and Hamilton Depression scales by week 2 that remained significant by week 8. On the physician's global impression of change since baseline, all completers were rated at least "much improved." Seven experienced a 50% or greater reduction in panic frequency at week 8 compared to baseline. These results suggest that alprazolam is likely to be of benefit to this patient population.
authors.affiliation: Department of Psychiatry, University of Missouri, Columbia 65201.
authors.forename: B D
authors.initials: BD
authors.lastname: Beitman
authors.forename: I M
authors.initials: IM
authors.lastname: Basha
authors.forename: L H
authors.initials: LH
authors.lastname: Trombka
authors.forename: M A
authors.initials: MA
authors.lastname: Jayaratna
authors.forename: B D
authors.initials: BD
authors.lastname: Russell
authors.forename: S K
authors.initials: SK
authors.lastname: Tarr
mesh_terms: D000328:Adult; D000525:Alprazolam / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000787:Angina Pectoris / Q000150:complications / Q000188:drug therapy*; D001007:Anxiety / Q000188:drug therapy; D001259:Ataxia / Q000139:chemically induced; D002637:Chest Pain / Q000150:complications / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003221:Confusion / Q000139:chemically induced; D004334:Drug Administration Schedule; D005239:Fear; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010200:Panic
chemical_list: D000525:Alprazolam