title: Plasma levels and therapeutic response with trimipramine treatment of endogenous depression.
abstract: In a 6-week, double-blind study involving 34 endogenously depressed patients, plasma trimipramine levels of two dosage groups, 75-mg/day and 150-mg/day, were compared with regard to clinical efficacy as determined by scores on the Hamilton Rating Scale for Depression, the Clinical Global Impressions scale, and the Zung Self-Rating Depression Scale. Both dosage levels of trimipramine produced prompt, consistent, and progressive antidepressant effects. No correlation between plasma levels and clinical efficacy was found.
authors.affiliation: Department of Psychiatry, Medical College of Pennsylvania, Philadelphia 19129.
authors.forename: G M
authors.initials: GM
authors.lastname: Simpson
authors.forename: E H
authors.initials: EH
authors.lastname: Pi
authors.forename: L
authors.initials: L
authors.lastname: Gross
authors.forename: D
authors.initials: D
authors.lastname: Baron
authors.forename: M
authors.initials: M
authors.lastname: November
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D003984:Dibenzazepines / Q000097:blood*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011897:Random Allocation; D012894:Sleep Stages; D014299:Trimipramine / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D014987:Xerostomia / Q000139:chemically induced
chemical_list: D003984:Dibenzazepines; D014299:Trimipramine