title: Genotoxicity of selenite in diploid yeast.
abstract: Selenite, a chemical of industrial importance and also an antimutagenic/anticarcinogenic agent, was tested for mutagenic and recombinogenic effects in 2 diploid yeast strains, Saccharomyces cerevisiae BZ 34 and D7. Selenite induced gene conversion and toxicity in BZ 34 and a variety of genetic events, viz. back-mutation, gene conversion, mitotic crossing-over, aberrant colony formation and also toxicity in the D7 strain. In both strains, the genetic effects of selenite showed a peak and a decline during 5 h of treatment while its toxicity increased marginally during 1-5 h. In the BZ 34 strain, the presence of glutathione (GSH) during selenite treatment greatly enhanced the convertogenic and toxic effects of selenite.
authors.affiliation: Division of Radiological Protection, Bhabha Atomic Research Centre, Trombay, Bombay, India.
authors.forename: K B
authors.initials: KB
authors.lastname: Anjaria
authors.forename: U
authors.initials: U
authors.lastname: Madhvanath
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D003434:Crossing Over, Genetic / Q000187:drug effects; D005785:Gene Conversion / Q000187:drug effects; D005978:Glutathione; D009152:Mutagenicity Tests; D010084:Oxidation-Reduction; D011995:Recombination, Genetic / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D020887:Selenious Acid; D012643:Selenium / Q000633:toxicity*
chemical_list: D020887:Selenious Acid; D005978:Glutathione; D012643:Selenium