title: The effect of protein malnutrition on the IgA immune response in mice.
abstract: The influence of protein malnutrition on the IgA immune response was determined in BALB/c mice fed isocaloric diets containing 20% (control), 4%, or 2% protein. We describe here a severely protein-deficient state (6 weeks on a 2% protein diet) and a moderately malnourished state (6-8 weeks on a 4% protein diet). The total IgA concentration in intestinal washes, as determined by radial immunodiffusion, was reduced at 6 and 8 weeks in the 4% diet group and at 6 weeks in the 2% diet group, compared to the controls. Serum IgA levels were significantly elevated in both the 2% and 4% diet-fed groups at all time intervals. The IgA anti-sheep red blood cell (SRBC) plaque-forming cell (PFC) response generated after oral immunization with SRBC did not differ between the control and the 4% diet group at any time interval, yet the IgA PFC/spleen response was significantly reduced in the 2% diet group at all time intervals studied. However, the IgA PFC/10(6) spleen cells was reduced only with the 2% protein diet group at 6 weeks. Severely protein-deficient mice replenished with the control diet for 3 weeks showed a recovery to values similar to the 8-week control group of both the IgA PFC response and the total IgA concentration in intestinal washes. These results suggest that protein deprivation leads to a reversible reduction in the IgA response to antigens encountered at the intestinal mucosa.
authors.affiliation: Department of Medical Microbiology and Immunology, Texas A & M University, College Station 77843.
authors.forename: D W
authors.initials: DW
authors.lastname: McGee
authors.forename: D N
authors.initials: DN
authors.lastname: McMurray
mesh_terms: D000818:Animals; D005260:Female; D006462:Hemolytic Plaque Technique; D007070:Immunoglobulin A / Q000032:analysis* / Q000276:immunology; D007413:Intestinal Mucosa / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009752:Nutritional Status; D011488:Protein Deficiency / Q000276:immunology*; D013154:Spleen / Q000276:immunology
chemical_list: D007070:Immunoglobulin A