Inverse correlation between combined mutagenicity in Salmonella typhimurium and strength of coordinate bond in mixtures of cobalt(II) chloride and 4-substituted pyridines.
Cobalt(II) chloride (CoCl2), non-mutagenic by itself, has been tested for mutagenic activity in the presence of 4-substituted pyridines in the test strains of Salmonella typhimurium. CoCl2 was found to be mutagenic in strains TA1537 and TA2637, when combined pyridine, with methyl isonicotinate, 4-methyl-pyridine, 4-ethylpyridine, 4-chloropyridine or 4-bromopyridine. Mixtures of CoCl2 and isonicotinic acid, 4-cyanopyridine, 4-aminopyridine, or 4-dimethylaminopyridine exhibited no mutagenicity. Judging from the spectral observations, such combined mutagenicity may be due to the formation of moderate to weak complexes between these compounds and the Co(II) cation.
Ogawa
H I
HI
Faculty of Engineering, Kyushu Institute of Technology, Kitakyushu, Japan.
Liu
S Y
SY
Sakata
K
K
Niyitani
Y
Y
Tsuruta
S
S
Kato
Y
Y
D003035:Cobalt / Q000494:pharmacology*; D004347:Drug Interactions; D007539:Isonicotinic Acids / Q000494:pharmacology; D009152:Mutagenicity Tests; D011725:Pyridines / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects*; D013329:Structure-Activity Relationship
D007539:Isonicotinic Acids; D011725:Pyridines; D003035:Cobalt; C018021:cobaltous chloride