In-vitro activity of antifungal agents in combination with four quinolones.
The antifungal activity of amphotericin B (AMB), mepartricin (MEPA), 5-fluorocytosine (5FC) and three imidazoles was tested in combination with each of four quinolones against 60 clinical yeast isolates. The inhibitory activity of AMB and MEPA was marginally enhanced by the azaquinolones, nalidixic acid (NAL) and enoxacin (ENO), but there was antagonism when combined with the fluorinated quinolones ciprofloxacin (CIP) and norfloxacin (NOR). All quinolones except NAL partially antagonised 5FC. Miconazole (MCZ), ketoconazole (KTZ) and itraconazole (ITZ) were each found to be synergistic with low concentrations of the quinolones, and also with high concentrations of NAL and ENO, but were strongly antagonised by high concentrations of CIP and NOR.
Petrou
M A
MA
Department of Medical Microbiology, Charing Cross and Westminster Medical School, London, UK.
Rogers
T R
TR
D042462:4-Quinolones; D000666:Amphotericin B / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000890:Anti-Infective Agents; D000935:Antifungal Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D002939:Ciprofloxacin / Q000494:pharmacology; D004338:Drug Combinations; D015365:Enoxacin; D005437:Flucytosine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008613:Mepartricin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009268:Nalidixic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D009287:Naphthyridines / Q000494:pharmacology; D009643:Norfloxacin / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects*
D042462:4-Quinolones; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D004338:Drug Combinations; D009287:Naphthyridines; D011804:Quinolines; D008613:Mepartricin; D015365:Enoxacin; D009268:Nalidixic Acid; D002939:Ciprofloxacin; C028959:citrated nalidixic acid; D000666:Amphotericin B; D005437:Flucytosine; D009643:Norfloxacin