title: Secretion of interleukin 1 (IL-1) by peritoneal macrophages upon contact with syngeneic T cells is Ia-restricted and antigen-independent process.
abstract: We deliver an evidence that secretion of interleukin 1 by macrophages upon contact with T cells is an Ia-restricted and antigen-independent event. Antigen-specific T cell lines or quiescent thymocytes induce comparable quantities of IL-1 from Ia-compatible macrophages. Addition of antigen together with antigen-specific T cells does not increase production of IL-1. Con A-activated thymocyte-derived blasts induce less IL-1 than unstimulated thymocytes. Peritoneal B cells do not secrete IL-1 although they present GAT effeciently to GAT-specific T cell clones. Lastly, the production of IL-1 can be inhibited by a treatment of macrophages with monoclonal antibodies against Ia but not H-2D antigens. The results indicate that the release of IL-1 is solely a result of an interaction between Ia molecules on macrophages and the receptor for Ia on interacting T cells. This process does not require antigen/lectin bridge between the interacting cells.
authors.affiliation: Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
authors.forename: M
authors.initials: M
authors.lastname: Zimecki
authors.forename: Z
authors.initials: Z
authors.lastname: Wieczorek
authors.forename: J A
authors.initials: JA
authors.lastname: Kapp
authors.forename: C W
authors.initials: CW
authors.lastname: Pierce
mesh_terms: D000818:Animals; D002460:Cell Line; D005260:Female; D007378:Interleukins / Q000378:metabolism*; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D008285:Major Histocompatibility Complex; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010529:Peritoneal Cavity / Q000166:cytology*; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
chemical_list: D007378:Interleukins