Immunohistological evaluation of endothelial markers and basement membrane components in port-wine stains.
As shown by an immunohistological study, the endothelial cells in the lesions of port-wine stains (PWSs), investigated for factor VIII-related antigen and Ulex europaeus agglutinin I lectin, were found to be swollen or flattened corresponding to mild or pronounced dilatation of vessels, respectively. Furthermore, dilated vessels in the lesional skin exhibited a broader staining for type IV collagen, laminin and fibronectin, which, however, was not considered to be of primary pathogenetic importance for vessel dilatation in PWSs. As concluded from the number of vessels, no vascular proliferation occurred, which indicates that PWS is not a true hemangioma but a special clinical type of telangiectasia.
Mitsuhashi
Y
Y
Department of Dermatology, University Hospital, Zürich, Switzerland.
Odermatt
B F
BF
Schneider
B V
BV
Schnyder
U W
UW
D000293:Adolescent; D000328:Adult; D001485:Basement Membrane / Q000032:analysis / Q000166:cytology*; D002648:Child; D004727:Endothelium / Q000032:analysis / Q000166:cytology*; D005455:Fluorescent Antibody Technique; D006391:Hemangioma / Q000032:analysis / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D012878:Skin Neoplasms / Q000032:analysis / Q000473:pathology*; D013684:Telangiectasis / Q000473:pathology*