A study on the adjuvant activity of palatine tonsil.
The involvement of non-specific factors in the onset of focal infection should never be ignored. We pay attention to the adjuvant activity of tonsil as one of various kinds of nonspecific factors. We confirmed the presence of such substances with adjuvant activity as lipopolysaccharides and muramyl dipeptide in the lacunar debris of tonsil. Then, using experimental animals with adjuvant induced arthritis, the study was made to determine whether the lacunar debris actually exerts adjuvant activity. We demonstrated the presence of adjuvant activity in the lacunar debris.
Yamazaki
Y
Y
Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan.
Hashiguchi
K
K
Ogawa
H
H
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology / Q000473:pathology; D005260:Female; D005490:Focal Infection / Q000276:immunology; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006614:Hindlimb; D006801:Humans; D014066:Palatine Tonsil / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D011917:Rats, Inbred Lew
D000276:Adjuvants, Immunologic; D005620:Freund's Adjuvant