[The action of the venom of the spider Eresus niger on the neuromuscular synapses of the frog].
The effect of Eresus niger spider venom on frog neuromuscular preparations has been studied using the intracellular microelectrodes. The spider venom has been found to block both spontaneous and elicited transmitter release and possesses the phospholipase activity. It has been suggested that the venom blocking synaptic transmission results from its phospholipase activity by analogy with the action of snake presynaptic neurotoxins.
Usmanov
P B
PB
Kalikulov
D
D
Nenilin
A B
AB
Nasyrov
K E
KE
Akhmedov
K D
KD
D000818:Animals; D001180:Arthropod Venoms / Q000494:pharmacology*; D003864:Depression, Chemical; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D010740:Phospholipases / Q000032:analysis / Q000494:pharmacology; D011896:Rana temporaria; D013111:Spider Venoms / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects* / Q000502:physiology
D001180:Arthropod Venoms; D013111:Spider Venoms; D010740:Phospholipases
Deĭstvie iada pauka Eresmus niger na nervno-myshechnye sinapsy liagushki.