Six-month effects of a sanguinarine dentifrice on plaque and gingivitis.
A six-month, double-blind clinical trial was conducted to determine the effectiveness of a sanguinarine-containing dentifrice in reducing plaque and gingival inflammation. One hundred twenty adult volunteers were randomly assigned to a control or experimental group. The test dentifrice contained 750 mcg/g of sanguinaria extract. A dentifrice of similar composition without sanguinarine was used as the placebo. Plaque and gingival inflammation scores were recorded for four surfaces on each of 12 index teeth at baseline, one-, three, and six-months. Matched pair t-test analyses showed no significant differences between experimental and control groups for mean six-month changes in plaque and gingival inflammation scores in analyses using all 48 sites per subject or in analyses of only the 24 interproximal sites. No long-term reduction was demonstrated in plaque or gingival inflammation with the use of a sanguinarine-containing dentifrice.
Mauriello
S M
SM
Department of Dental Ecology, School of Dentistry, University of North Carolina, Chapel Hill 27514.
Bader
J D
JD
D000328:Adult; D000470:Alkaloids / Q000627:therapeutic use*; D053119:Benzophenanthridines; D002986:Clinical Trials as Topic; D003773:Dental Plaque / Q000188:drug therapy*; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D005891:Gingivitis / Q000188:drug therapy*; D006801:Humans; D007546:Isoquinolines; D011897:Random Allocation; D013223:Statistics as Topic; D013997:Time Factors
D000470:Alkaloids; D053119:Benzophenanthridines; D003802:Dentifrices; D007546:Isoquinolines; C005705:sanguinarine