title: Influence of long-term treatment with hydrazinophthalazines on the activity of lysosomal exoglycosidases in rat tissues.
abstract: Serum antinuclear antibodies were induced in rats by treatment with hydralazine or todralazine, given in daily dose of 25 mg/kg of body wt. for 12 months. An increased activity of alpha-glucosidase, beta-glucosidase, beta-galactosidase, alpha-fucosidase, beta-xylosidase was found in heart muscle, liver, kidney and lung. Hydralazine produced a more significant increase in the enzyme activity than todralazine. The obtained results suggest drug-induced connective tissue damage, probably of an inflammatory type. The mechanism of this phenomenon and its relationship to immunological alterations remain unclear.
authors.affiliation: Department of Clinical Chemistry and Laboratory Diagnostics, Silesian School of Medicine, Katowice, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Olczyk
authors.forename: E J
authors.initials: EJ
authors.lastname: Kucharz
authors.forename: M
authors.initials: M
authors.lastname: Drózdz
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D004195:Disease Models, Animal; D006026:Glycoside Hydrolases / Q000378:metabolism*; D006830:Hydralazine / Q000494:pharmacology*; D006834:Hydrazines / Q000494:pharmacology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D014032:Todralazine / Q000494:pharmacology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D006834:Hydrazines; D006830:Hydralazine; D006026:Glycoside Hydrolases; D014032:Todralazine