Morphological effects of pyronaridine on malarial parasites.
The ultrastructural changes caused by a new antimalarial drug, pyronaridine, were investigated using mice infected with erythrocytic forms of Plasmodium berghei and P. falciparum cultivated in vitro in human erythrocytes. The first changes observed in both parasites after exposure to pyronaridine occurred in the food vacuoles. This suggests that the target organelle of this drug may be the food vacuole of malarial parasites. In addition, rapid alterations were also noted within the pellicular complex of both plasmodia.
Wu
L J
LJ
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, WHO Collaborating Centre of Malaria, Shanghai.
Rabbege
J R
JR
Nagasawa
H
H
Jacobs
G
G
Aikawa
M
M
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D008854:Microscopy, Electron; D009287:Naphthyridines / Q000494:pharmacology*; D009940:Organoids / Q000187:drug effects / Q000648:ultrastructure; D010962:Plasmodium berghei / Q000187:drug effects* / Q000648:ultrastructure; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000648:ultrastructure; D014617:Vacuoles / Q000187:drug effects / Q000648:ultrastructure
D000962:Antimalarials; D009287:Naphthyridines; C027871:pyronaridine