The role of epsilon-aminocaproic acid in reducing bleeding after cardiac operation: a double-blind randomized study.
Sixty patients scheduled for elective coronary artery bypass graft operations were randomly assigned to receive epsilon-aminocaproic acid or placebo to test whether antifibrinolytic therapy would decrease postoperative bleeding. A small but significant decrease in bleeding was observed in the treated group without complications resulting from treatment with epsilon-aminocaproic acid.
Vander Salm
T J
TJ
Department of Surgery, University of Massachusetts Medical Center, Worcester 01655.
Ansell
J E
JE
Okike
O N
ON
Marsicano
T H
TH
Lew
R
R
Stephenson
W P
WP
Rooney
K
K
D000614:Aminocaproates / Q000627:therapeutic use*; D015119:Aminocaproic Acid / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D001026:Coronary Artery Bypass; D004311:Double-Blind Method; D005260:Female; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011183:Postoperative Complications / Q000517:prevention & control*; D011897:Random Allocation
D000614:Aminocaproates; D015119:Aminocaproic Acid