Characteristics of blood cells responding to insulin in children with insulin-dependent diabetes.
Cells responding to insulin in peripheral blood of children with insulin-dependent diabetes mellitus were characterized using monoclonal antibodies and autoradiography. The results indicate that the cells responding to insulin were T cells mainly of the helper (CD4+) phenotype and that they required adherent cells of the monocyte/macrophage lineage for proliferation to occur.
Scheinin
T
T
Department of Microbiology, Aurora Hospital, Helsinki, Finland.
D001773:Blood Cells / Q000187:drug effects* / Q000276:immunology; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D007328:Insulin / Q000276:immunology / Q000494:pharmacology*; D007330:Insulin Antibodies / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D007328:Insulin; D007330:Insulin Antibodies