title: Double blind controlled randomized study on azathioprine efficacy in multiple sclerosis. Preliminary results.
abstract: The preliminary results of a double blind controlled prospective randomized trial of Azathioprine for therapeutic efficacy in 38 patients with Multiple Sclerosis are reported. Progression of the disease is significantly reduced in Azathioprine-treated group in comparison to Placebo-treated patients, but this effect is reached only after 3 years of treatment (P less than 0.025) regardless of the clinical course and without affecting relapse rate.
authors.affiliation: Istituto Neurologico, C. Besta, Milano.
authors.forename: C
authors.initials: C
authors.lastname: Milanese
authors.forename: L
authors.initials: L
authors.lastname: La Mantia
authors.forename: A
authors.initials: A
authors.lastname: Salmaggi
authors.forename: A
authors.initials: A
authors.lastname: Campi
authors.forename: C
authors.initials: C
authors.lastname: Bortolami
authors.forename: L
authors.initials: L
authors.lastname: Tajoli
authors.forename: A
authors.initials: A
authors.lastname: Nespolo
authors.forename: F
authors.initials: F
authors.lastname: Corridori
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy*; D011897:Random Allocation
chemical_list: D001379:Azathioprine