[Soluble and membrane-bound forms of neutral alpha-glucosidase in human urine in normal conditions and in kidney diseases].
Soluble and membrane-bound forms of neutral alpha-glucosidase, which are immunologically similar to the corresponding forms of kidney enzymes, were found in urine of healthy persons and of patients with kidney impairments. Membrane-bound enzyme was only slightly active in urine of healthy persons and constituted 3-10% of total urine activity although the ratio of membrane-bound enzyme was simultaneously elevated under pathological conditions. The increased rate of soluble enzyme secretion was responsible for distinct activation of neutral alpha-glucosidase in urine of the patients with kidney impairments.
Ushakova
N A
NA
Lavrenova
T P
TP
Kazlas
E V
EV
Tomilina
N A
NA
Zubkin
M L
ML
D006801:Humans; D007668:Kidney / Q000201:enzymology*; D007674:Kidney Diseases / Q000175:diagnosis / Q000201:enzymology* / Q000652:urine; D008871:Microvilli / Q000201:enzymology; D017830:Octoxynol; D011092:Polyethylene Glycols; D012016:Reference Values; D012995:Solubility; D000520:alpha-Glucosidases / Q000302:isolation & purification / Q000652:urine*
D011092:Polyethylene Glycols; D017830:Octoxynol; D000520:alpha-Glucosidases
Rastvorimaia i membranno-sviazannaia formy neĭtral'noĭ alpha-gliukozidazy mochi cheloveka v norme i pri zabolevaniiakh pochek.