title: Aminoacetyl derivatives of 1,5-benzodiazepin-2-one.
abstract: A series of six compounds, 5-chloroacetyl-4-methyl-1H-tetrahydro-1,5-benzodiazepin-2-one and 5-dialkilaminoacetyl derivatives of 4-methyl-1H-tetrahydro-1,5-benzodiazepin-2-one, have been synthesized. 5-Diizobutylaminoacetyl-4-methyl-1H-tetrahydro-1,5-benzodiazepi n-2-one showed weak analgesic and antiinflammatory activity.
authors.affiliation: Department of Technology of Drugs, Medical Academy, Wrocław, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Nawojski
authors.forename: W
authors.initials: W
authors.lastname: Nawrocka
authors.forename: H
authors.initials: H
authors.lastname: Liszkiewicz
authors.forename: L
authors.initials: L
authors.lastname: Krzywosiński
authors.forename: M
authors.initials: M
authors.lastname: Bogdal
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001570:Benzodiazepinones; D009270:Naloxone