Unique HLA-D region heterogeneity in American blacks.
American blacks and whites show heterogeneity in serologically detected and lymphocyte-defined HLA-D region antigen frequencies. Also, alterations in linkage relationships are seen in DR and DQ specificities. Since homozygous typing cells probably identify a cluster of specificities that are usually found in linkage disequilibrium in a given population, it is not surprising that blacks have unique HLA-D types. The significance of the observed differences in the function of class II molecules is being investigated.
Dunston
G M
GM
Howard University College of Medicine, Washington, DC.
Hurley
C K
CK
Hartzman
R J
RJ
Johnson
A H
AH
D044383:Black People / Q000235:genetics*; D015342:DNA Probes; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059810:HLA-DR Serological Subtypes; D006650:Histocompatibility Testing; D006801:Humans; D014481:United States; D001741:Black or African American
D015342:DNA Probes; D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C097337:HLA-DR13 antigen