title: Carpal tunnel syndrome. A scientific basis for clinical care.
abstract: The series of experimental studies reviewed in this article supports a classification of median nerve compression at the wrist into early, intermediate, advanced, and acute nerve compression. The findings correlate well with experimental studies on the pathophysiology of nerve compression. A patient-specific management approach is recommended based upon the clinical and electrophysiologic findings which can be correlated with previously demonstrated intraneural pathologic changes.
authors.affiliation: Harvard Medical School, Boston, Massachusetts.
authors.forename: R H
authors.initials: RH
authors.lastname: Gelberman
authors.forename: B L
authors.initials: BL
authors.lastname: Rydevik
authors.forename: G M
authors.initials: GM
authors.lastname: Pess
authors.forename: R M
authors.initials: RM
authors.lastname: Szabo
authors.forename: G
authors.initials: G
authors.lastname: Lundborg
mesh_terms: D002349:Carpal Tunnel Syndrome / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D002370:Casts, Surgical; D006801:Humans; D008012:Lidocaine; D008475:Median Nerve / Q000503:physiopathology / Q000601:surgery; D009407:Nerve Block / Q000379:methods; D009431:Neural Conduction; D013165:Splints
chemical_list: D008012:Lidocaine