Molecular cloning of the zeta chain of the T cell antigen receptor.
The T cell antigen receptor is a multi-subunit receptor complex present on the surface of all mature and many developing T cells. It consists of clonotypic heterodimers noncovalently linked to five invariant chains that are encoded by four genes and referred to as the CD3 complex. The CD3 gamma, delta, and epsilon chains have been molecularly characterized. In this report the molecular cloning of a complementary DNA encoding the zeta chain of the murine T cell antigen receptor is described. The predicted protein sequence of the zeta chain suggests a structure distinct from those of any of the previously described receptor subunits.
Weissman
A M
AM
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892.
Baniyash
M
M
Hou
D
D
Samelson
L E
LE
Burgess
W H
WH
Klausner
R D
RD
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002462:Cell Membrane / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003001:Cloning, Molecular; D003488:Cyanogen Bromide; D004247:DNA / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D007163:Immunosorbent Techniques; D046911:Macromolecular Substances; D008565:Membrane Proteins; D051379:Mice; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009693:Nucleic Acid Hybridization; D010446:Peptide Fragments; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013601:T-Lymphocytes / Q000032:analysis; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
D046911:Macromolecular Substances; D008565:Membrane Proteins; D010446:Peptide Fragments; D012333:RNA, Messenger; D011948:Receptors, Antigen, T-Cell; C054979:antigen T cell receptor, zeta chain; D004247:DNA; D003488:Cyanogen Bromide