title: [Proposal for changing the ministerial instructions for antirabies prophylaxis in the light of the experience of the Centro Antirabbico di Roma].
abstract: Records of clinical assistance and of post-exposure antirabies prophylaxis from 4820 outpatients who attended the Antirabies Center of Rome following animal bites in 1986 were analysed. We observed a high proportion of people submitted to active immunization (44% received at least one shot of HDCV vaccine) in spite of the fact that rabies is absent from Central Italy since many decades in both wild and domestic animals. These considerations suggest the opportunity of a major revision of the official recommendations for rabies prevention, and we feel that different policies should be adopted in rabies enzootic areas (such as Northern Italy) compared to those where the risk is only potential. Immunization should be avoided after bites by rodents; passive immunization should be added to the vaccine after bites by wild animals in enzootic areas, while bites by cats and dogs, even uncaptured, will not be necessarily followed by vaccination in non enzootic areas.
authors.affiliation: I Cattedra di Igiene, Università di Roma La Sapienza.
authors.forename: G M
authors.initials: GM
authors.lastname: Fara
authors.forename: A
authors.initials: A
authors.lastname: Panà
authors.forename: C
authors.initials: C
authors.lastname: Signorelli
authors.forename: S
authors.initials: S
authors.lastname: Mancinelli
authors.forename: M C
authors.initials: MC
authors.lastname: Marazzi
authors.forename: L
authors.initials: L
authors.lastname: Palombi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000829:Animals, Domestic; D000835:Animals, Wild; D001733:Bites and Stings / Q000150:complications / Q000453:epidemiology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D004197:Disease Reservoirs; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007223:Infant; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011818:Rabies / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D012306:Risk; D013045:Species Specificity
chemical_list: D011819:Rabies Vaccines
vernacular_title: Contributi per una proposta di modifica delle istruzioni ministeriali per la profilassi antirabbica alla luce dell'esperienza del Centro Antirabbico di Roma.