Lesions of testis and epididymis associated with prenatal diethylstilbestrol exposure.
Cryptorchidism and retention of Müllerian duct structures occur with high frequency among the male offspring of CD-1 mice treated with 100 micrograms diethylstilbestrol/kg body weight on days 9 through 16 of pregnancy. Hyperplasia of the rete testis and Müllerian duct structures were found in many of the DES-treated male mice, as was a low but significant number of reproductive tract neoplasms.
Bullock
B C
BC
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Newbold
R R
RR
McLachlan
J A
JA
D000818:Animals; D004054:Diethylstilbestrol / Q000633:toxicity*; D004822:Epididymis / Q000187:drug effects*; D005260:Female; D008297:Male; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013736:Testicular Neoplasms / Q000139:chemically induced; D013737:Testis / Q000187:drug effects*
D004054:Diethylstilbestrol