title: The splanchnic organs as the source of toxic mediators in shock.
abstract: The splanchnic organs, and especially the pancreas and the small intestine, are susceptible to injury during ischemia and shock and the following reperfusion. This particular tissue injury is associated with a release of cardiotoxic and other toxic mediators which further aggravate the shock condition, leading to further tissue injury etc. Thereby a vicious circle is created, which is likely to contribute to collapse and death.
authors.affiliation: Department of Surgery, Lund University, Malmö General Hospital, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Haglund
mesh_terms: D001427:Bacterial Toxins / Q000502:physiology*; D006801:Humans; D007422:Intestines / Q000098:blood supply / Q000503:physiopathology*; D007511:Ischemia / Q000503:physiopathology; D010179:Pancreas / Q000098:blood supply / Q000503:physiopathology*; D012772:Shock, Septic / Q000503:physiopathology*; D013152:Splanchnic Circulation; D014118:Toxins, Biological / Q000502:physiology*; D014661:Vasoconstriction
chemical_list: D001427:Bacterial Toxins; D014118:Toxins, Biological