title: [Evaluation of the specific immune response after anti-rubella vaccination].
abstract: A selective rubella immunization program was carried out in the Siena (Italy) area since 1984. 912 schoolgirls aged 10 to 18 were screened for rubella antibodies. Seropositivity rates, increasing with age, appeared quite heterogenous among subjects living in different villages. Seronegative girls were partly voluntarily immunized with RA 27/3 live attenuated rubella vaccine. Serological and clinical controls performed on 238 subjects one month after immunization showed a 99.6% vaccine-induced seroconversion rate and mild post-vaccinal reactions in 26% of vaccinees. Serological control performed, on 172 subjects, at 8-12 days after vaccination revealed that in most cases vaccine induced haemagglutination-inhibiting antibodies are not detectable at the time. The results are discussed in relation to a forthcoming introduction of compulsory rubella vaccination in our Country.
authors.affiliation: Instituto di clinica delle malattie infettive Università, Siena.
authors.forename: C
authors.initials: C
authors.lastname: Cellesi
authors.forename: A
authors.initials: A
authors.lastname: Rossolini
authors.forename: G M
authors.initials: GM
authors.lastname: Rossolini
authors.forename: M L
authors.initials: ML
authors.lastname: Bianchi Bandinelli
authors.forename: M G
authors.initials: MG
authors.lastname: Cusi
authors.forename: P
authors.initials: P
authors.lastname: Egisto Valensin
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000276:immunology; D000918:Antibody Specificity; D002648:Child; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007558:Italy; D012411:Rubella Vaccine / Q000276:immunology*; D012412:Rubella virus / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D012411:Rubella Vaccine
vernacular_title: Valutazione della risposta immunitaria specifica dopo vaccinazione anti-rosolia.