title: Terodiline in the treatment of diurnal enuresis in children.
abstract: Efficacy and tolerance of the anticholinergic and calcium antagonistic drug terodiline (Mictrol) were investigated in comparison to placebo in 42 children with diurnal enuresis. The study was double-blind with a modified cross-over design with 2 treatment periods of 4 weeks. Terodiline in a daily dose of 25 mg was well tolerated. A statistically significant decrease in the number of wet episodes per day was found with terodiline when compared to placebo. In addition a high patient preference for terodiline was observed. This study shows that terodiline is effective in the treatment of daytime enuresis in children. The low incidence of side-effects also favours the use of terodiline in children.
authors.affiliation: St. Lars Primary Health Care Centre, Lund, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Elmér
authors.forename: J P
authors.initials: JP
authors.lastname: Nørgaard
authors.forename: J C
authors.initials: JC
authors.lastname: Djurhuus
authors.forename: T
authors.initials: T
authors.lastname: Adolfsson
mesh_terms: D000293:Adolescent; D002082:Butylamines / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004775:Enuresis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D011897:Random Allocation
chemical_list: D002082:Butylamines; D002121:Calcium Channel Blockers; C010637:terodiline