Activated Fc alpha T cells in Crohn's disease are involved in regulation of IgA.
Activated peripheral T cells (APT) of patients with Crohn's disease (CD) have been analysed for the expression of IgA-Fc receptors and for competence of IgA regulation. It was found that within the subset of APT an increased number of cells express binding sites for IgA (IgA-Fc), that was not found in other diseases with elevated numbers of APT. Moreover the number of IgA-Fc receptor expressing T cells was found to be increased in the inflamed mucosa too. Cocultures with autologous B cells revealed that isolated IgA-Fc receptor bearing T cells of patients with CD suppress IgA secretion. These data support the hypothesis that APT are involved in the immunopathogenesis of CD.
Raedler
A
A
Med. Dept. Univ., Hamburg, FRG.
Schreiber
S
S
Schulz
K H
KH
Peters
S
S
Greten
H
H
Thiele
H G
HG
D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D003424:Crohn Disease / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D011961:Receptors, Fc / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; C036832:Fc(alpha) receptor; D007070:Immunoglobulin A; D011961:Receptors, Fc