Pharmacokinetics of high-dose etoposide.
The pharmacokinetics of etoposide at doses of 1 gm/m2 to 3 gm/m2 were studied in patients with hematologic malignancies. The noncompartmental systemic clearance, mean residence time, steady-state volume of distribution, and elimination half-life were independent of the dose of etoposide, whereas the AUC was proportional to the dose. Comparison of these results with those reported previously indicates that etoposide exhibits linear pharmacokinetics over a thirtyfold range in doses (0.1 to 3 gm/m2).
Newman
E M
EM
Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA 91010.
Doroshow
J H
JH
Forman
S J
SJ
Blume
K G
KG
D000410:Alanine Transaminase / Q000097:blood; D016026:Bone Marrow Transplantation; D004305:Dose-Response Relationship, Drug; D005047:Etoposide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008657:Metabolic Clearance Rate
D005047:Etoposide; D000410:Alanine Transaminase