Effects of stress on muscarinic mechanisms.
Hyperactivity of muscarinic mechanisms may be involved in the patho-physiology of depressive disorders and stress. The literature emphasizes the impact of stress on aminergic networks and muscarinic mechanisms are generally not accorded a significant role in the neurobiology of stress. However, experiments in man and animals indicate that acute and chronic stress activate central muscarinic mechanisms. The literature reporting these results is reviewed.
Dilsaver
S C
SC
Department of Psychiatry, Ohio State University, Columbus 43210-1228.
D000818:Animals; D003863:Depression / Q000503:physiopathology*; D006801:Humans; D011976:Receptors, Muscarinic / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*
D011976:Receptors, Muscarinic