title: [Monitoring of sterilization procedures for plasma derivatives using bacteriophages].
abstract: Since 1968 the combination of beta-propiolactone (beta-PL) plus UV-inactivation for the sterilization of plasma derivatives is in use at Biotest. In 1981, a bacteriophage test system was established for routine monitoring of the efficacy of this sterilization procedure, using the bacteriophages phi x 174, phi e, Kappa and f2. In the period of 1981 to 1986, 88 control experiments were performed under production conditions demonstrating a mean inactivation of these test viruses of greater than or equal to 6.7 log10. This constant and high efficacy of the beta-PL/UV sterilization procedure guarantees the longstanding safety of beta-PL/UV sterilized blood derivatives. Bacteriophages are also useful experimental viruses for monitoring the efficacy of pasteurization processes.
authors.affiliation: Biotest Pharma Forschungsabteilung, Frankfurt am Main.
authors.forename: H
authors.initials: H
authors.lastname: Dichtelmüller
authors.forename: W
authors.initials: W
authors.lastname: Stephan
mesh_terms: D001793:Blood Preservation / Q000592:standards*; D001798:Blood Proteins / Q000592:standards; D003090:Coliphages / Q000187:drug effects / Q000528:radiation effects; D004926:Escherichia coli; D006801:Humans; D011420:Propiolactone; D013242:Sterilization / Q000592:standards*; D014466:Ultraviolet Rays
chemical_list: D001798:Blood Proteins; D011420:Propiolactone
vernacular_title: Kontrolle von Sterilisationsverfahren für Plasmaderivate mit Bakteriophagen.