Serum osteocalcin and other indices of bone formation: an 8-decade population study in healthy men and women.
In a study of 435 healthy men and women aged 17-97 yr, serum osteocalcin and alkaline phosphatase were measured together with 99TcMDP retention in women. In women, serum osteocalcin falls to a nadir at 35-39 yr, and the mean then rapidly rises 2-fold to a plateau from 50-75 yr. 99TcMDP retention falls to a minimum at 40-45 yr and then rises steadily with increasing age. Serum alkaline phosphatase rises in an indeterminate fashion from 20-25 yr onwards. Osteocalcin in men fell until age 60-70 yr and hardly changed thereafter, whereas serum alkaline phosphatase reached a minimum at age 30-40 yr and thereafter rose with age, as in women.
Worsfold
M
M
Charles Salt Research Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire, UK.
Sharp
C A
CA
Davie
M W
MW
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood*; D001846:Bone Development; D002135:Calcium-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin; D011863:Radioimmunoassay; D012737:Sex Factors; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics
D002135:Calcium-Binding Proteins; D015675:Osteocalcin; D000469:Alkaline Phosphatase; D013669:Technetium Tc 99m Medronate