[Quantitative analysis of survival during syngeneic and semisyngeneic bone marrow transplantation: relation of the protective effect and the ability to induce secondary disease as affected by differences in the major histocompatibility locus].
The protective effect of bone marrow (BM) with both syngeneic and semisyngeneic transplantation is an exponential function of the number of transplanted cells. The regression coefficient in the logarithmic equation represents a fraction of hemopoiesis repair units (HRU). The quantitative analysis of the remote death of recipients of the parents' BM shows that the secondary disease (SD) is caused by other than HRU cells which is in agreement with the data obtained by other methods. The fraction of BM cells that induces SD is lower than the fraction of HRU. This helps to find an optimum BM dose range within which the risk of the SD-induced death is minimized.
Samoĭlina
N L
NL
Konradov
A A
AA
D000818:Animals; D016026:Bone Marrow Transplantation; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology*; D008285:Major Histocompatibility Complex; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000401:mortality / Q000517:prevention & control*; D014185:Transplantation, Isogeneic
Kolichestvennyĭ analiz vyzhivaemosti pri singennoĭ i semisingennoĭ transplantatsii kostnogo mozga: sootnoshenie zashchitnogo éffekta i sposobnosti vyzyvat' vtorichnuiu bolezn' pri razlichiiakh po glavnomu lokusu gistosovmestimosti.