title: Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas.
abstract: The acute effects of recombinant human interleukin-1 beta (rIL-1) on basal and glucose-stimulated insulin release were investigated in the isolated perfused pancreas. At a concentration of 20 micrograms/l rIL-1 had no effect on basal insulin release, but increased the total amount of insulin released during first and second phase insulin release in response to 20 mmol/l D-glucose in the rat pancreas (P less than 0.05). In addition, 26 micrograms/l of rIL-1 potentiated insulin release in response to square wave infusions of stimulatory concentrations of glucose (11 mmol/l) in the porcine pancreas. We hypothesize that IL-1 in the systemic circulation may affect B cell function in vivo.
authors.affiliation: Steno Memorial Hospital, Gentofte, Denmark.
authors.forename: L D
authors.initials: LD
authors.lastname: Wogensen
authors.forename: T
authors.initials: T
authors.lastname: Mandrup-Poulsen
authors.forename: H
authors.initials: H
authors.lastname: Markholst
authors.forename: J
authors.initials: J
authors.lastname: Mølvig
authors.forename: A
authors.initials: A
authors.lastname: Lernmark
authors.forename: J J
authors.initials: JJ
authors.lastname: Holst
authors.forename: C A
authors.initials: CA
authors.lastname: Dinarello
authors.forename: J
authors.initials: J
authors.lastname: Nerup
mesh_terms: D000818:Animals; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D010477:Perfusion; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine
chemical_list: D007328:Insulin; D007375:Interleukin-1