Genetic and environmental influences on behavioral and neurochemical aspects of emotionality in rats.
Three pairings of rats (two derived from divergent, selective breeding and one from divergent environmental conditions) were compared with regard to behavioral and hormonal parameters. Striking differences were observed: results obtained in our own laboratory as well as those found in a review of the literature pointed to higher emotionality (e.g., increased defecation and corticosterone secretion, etc.) in Roman low-avoidance, Wistar-Kyoto and group-housed rats, as compared to their respective counterparts, Roman high-avoidance, spontaneously hypertensive, and individually housed Wistar rats. Concomitant receptor binding studies reviewed here (3H-diazepam- and 3H-imipramine-binding sites) have revealed, however, less consistent intrapair differences.
Gentsch
C
C
Psychiatrische Universitätsklinik Basel, Biochem. Labor, Switzerland.
Lichtsteiner
M
M
Feer
H
H
D000818:Animals; D001522:Behavior, Animal; D001569:Benzodiazepines / Q000378:metabolism; D004195:Disease Models, Animal; D004644:Emotions; D004777:Environment; D005823:Genetics; D006801:Humans; D001523:Mental Disorders / Q000209:etiology / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains; D011955:Receptors, Drug / Q000502:physiology
D011955:Receptors, Drug; D001569:Benzodiazepines