title: Early assessment of the effect of map-guided transcatheter intracardiac electric shock on sustained ventricular tachycardia secondary to coronary artery disease.
abstract: Short-term efficacy of transcatheter intracardiac electric shock was evaluated in 25 patients with recurrent sustained ventricular tachycardia (VT) secondary to coronary artery disease. Pace mapping and activation sequence mapping during VT were both used to direct intracardiac electric shocks applied between the distal electrode of the catheter (cathode) and a chest wall plate (anode) using a mean total energy of 588 +/- 209 J/patient. The short-term outcome of the procedure was considered successful in 3 patients (12%) who neither developed spontaneous VT nor had sustained VT in response to programmed electrical stimulation 1 week after the procedure. The short-term outcome in the remaining 22 patients (88%) was considered unsuccessful: 7 of the 22 patients developed spontaneous sustained VT and in 19 patients, including 15 with no spontaneous VT, sustained VT was still inducible by programmed electrical stimulation 7 +/- 2 days after the intracardiac electric shock. All 22 patients were subsequently treated with other modes of antiarrhythmic therapy. Using the technique described, the short-term efficacy of map-directed transcatheter intracardiac electric shock in eliminating VT is poor.
authors.affiliation: Harvard Medical School, Massachusetts General Hospital, Boston 02114.
authors.forename: H
authors.initials: H
authors.lastname: Garan
authors.forename: D
authors.initials: D
authors.lastname: Kuchar
authors.forename: C
authors.initials: C
authors.lastname: Freeman
authors.forename: D
authors.initials: D
authors.lastname: Finkelstein
authors.forename: J N
authors.initials: JN
authors.lastname: Ruskin
mesh_terms: D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D006328:Cardiac Catheterization; D002304:Cardiac Pacing, Artificial; D003131:Combined Modality Therapy; D003327:Coronary Disease / Q000150:complications*; D004599:Electric Stimulation Therapy / Q000379:methods*; D004562:Electrocardiography; D005069:Evaluation Studies as Topic; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000150:complications; D009206:Myocardium / Q000473:pathology*; D011446:Prospective Studies; D013610:Tachycardia / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors
chemical_list: D000889:Anti-Arrhythmia Agents