Effect of 15-deoxyspergualin on experimental organ transplantation.
DSPG had a definite but relatively feeble immunosuppressive effect in rats undergoing heterotopic heart transplantation and in dogs after renal transplantation. The drug was toxic in both species, although less so in rats. In dogs, synergistic interactions with cyclosporine and steroids were not evident.
Todo
S
S
Department of Surgery, University of Pittsburgh, PA 15213.
Murase
N
N
Kahn
D
D
Pan
C E
CE
Okuda
K
K
Cemej
S
S
Casavilla
A
A
Mazzaferro
V
V
Ghalab
A
A
Rhoe
B S
BS
D000818:Animals; D003524:Cyclosporins / Q000008:administration & dosage; D004285:Dogs; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000187:drug effects; D006146:Guanidines / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D016027:Heart Transplantation; D007166:Immunosuppressive Agents / Q000627:therapeutic use* / Q000633:toxicity; D016030:Kidney Transplantation; D011241:Prednisone / Q000008:administration & dosage; D051381:Rats; D011912:Rats, Inbred ACI / Q000276:immunology; D011917:Rats, Inbred Lew / Q000276:immunology
D003524:Cyclosporins; D006146:Guanidines; D007166:Immunosuppressive Agents; C037258:gusperimus; D011241:Prednisone