title: The role of radiation therapy in the treatment of recurrent adult laryngeal papillomatosis.
abstract: Laryngeal papillomatosis is an uncommon condition in the adult, but it can be severe enough to require tracheostomy for obstructive changes following multiple recurrences, despite surgical local excisions and medical therapies. Few satisfactory treatments are available for such cases to restore both airway function and speech. Some patients may require laryngectomy for progressive dysfunction. The role of radiation therapy has been controversial, with some reports of malignant transformation following treatment. The authors describe two cases treated with irradiation, resulting in complete clearance of the lesions and return of airway and vocal function. Follow-up is given, and the available literature is reviewed.
authors.affiliation: Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee 53226.
authors.forename: R W
authors.initials: RW
authors.lastname: Byhardt
authors.forename: U
authors.initials: U
authors.lastname: Almagro
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy*; D010212:Papilloma / Q000473:pathology / Q000532:radiotherapy*; D014140:Tracheotomy