Evaluation of the activity of the carbocysteine-sobrerol combination on mucus spinnability.
Among the rheological properties of bronchial mucus, "spinnability", i.e. the ability to form threads under the effect of traction, should be regarded as the most closely related to the mucociliary transport function. In the present study the "spinnability" parameter was included in the functional tests aimed at evaluating the efficacy of the carbocysteine-sobrerol combination in 16 patients suffering from chronic abstructive lung disease with bronchial hypersection. Treatment was administered for ten days under double-blind conditions compared with a placebo. The results obtained showed the tested combination to be able to favourably affect all the most important rheological parameters of mucus, including spinnability, leading to a rapid disappearance of signs and symptoms and to the improvement of the most important respiratory function indexes.
Distefano
S M
SM
Institute of Respiratory Disease, University of Catania, Italy.
Palermo
F
F
Crimi
N
N
Mistretta
A
A
Pamparana
F
F
Messa
A
A
D002233:Carbocysteine / Q000008:administration & dosage / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003545:Cysteine / Q000031:analogs & derivatives*; D004311:Double-Blind Method; D004338:Drug Combinations; D005100:Expectorants / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009093:Mucus / Q000187:drug effects*; D011897:Random Allocation; D013729:Terpenes / Q000008:administration & dosage / Q000494:pharmacology*; D014797:Vital Capacity
D004338:Drug Combinations; D005100:Expectorants; D013729:Terpenes; D002233:Carbocysteine; C003316:sobrerol; D003545:Cysteine