Modulation of the pattern of axonal projections of a leech motor neuron by ablation or transplantation of its target.
The sixth segmental ganglion in the ventral nerve cord of the leech H. medicinalis contains a bilateral pair of rostral penile evertor motor neurons (RPEs) that in the adult innervate the male genitalia. During embryogenesis, the RPEs extend numerous extraganglionic projections. Only two of these innervate the target and are normally retained in the adult, while the others retract. Early, but not late, removal of the male genitalia results in the indefinite retention and continued growth of projections that would normally retract. Any of these projections can innervate targets transplanted to ectopic locations. We conclude that an RPE motor neuron requires a signal, provided by its interaction with the target organ during a critical period, in order to stop extending axons, stabilize those axons that contact the target, and retract those that do not.
Baptista
C A
CA
Department of Biological Sciences, Columbia University, New York, New York 10027.
Macagno
E R
ER
D000818:Animals; D001369:Axons / Q000502:physiology*; D005837:Genitalia, Male / Q000196:embryology / Q000294:innervation; D007865:Leeches / Q000196:embryology / Q000502:physiology*; D008297:Male; D009046:Motor Neurons / Q000502:physiology*; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D009919:Orchiectomy; D000093667:Penile Transplantation