Release of prostacyclin from the dog saphenous vein by 5-hydroxytryptamine.
5-Hydroxytryptamine (5-HT) stimulated the release of prostacyclin (PGI2) from strips of the dog saphenous vein. This stimulation was maintained after mechanical removal of the endothelium. The effect of 5-HT was mimicked by alpha-methyl-5-hydroxytryptamine (alpha-CH3-5-HT) but not by 5-carboxamidotryptamine (5-CT) and it was inhibited by ritanserin. It is concluded that, in the dog saphenous vein, the stimulation of PGI2 release by 5-HT involves 5-HT2 receptors distinct from the '5-HT1-like' receptors that mediate contraction of the vessel.
Kokkas
B
B
Institute of Interdisciplinary Research, School of Medicine, Université Libre de Bruxelles, Campus Erasme, Belgium.
Boeynaems
J M
JM
D000818:Animals; D004285:Dogs; D011464:Epoprostenol / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D012501:Saphenous Vein / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D011464:Epoprostenol