Sequence-specific chemical modification of a hybrid bacteriophage M13 single-stranded DNA by alkylating oligonucleotide derivatives.
Alkylating oligonucleotide derivatives react with the complementary sequences in hybrid M13mp7 bacteriophage single-stranded DNA and destroy the infecting ability of the DNA. The reagents do not damage M13mp9 single-stranded DNA lacking the target nucleotide sequence.
Vlassov
V V
VV
Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk.
Zarytova
V F
VF
Kutyavin
I V
IV
Mamaev
S V
SV
D000478:Alkylation; D001483:Base Sequence; D003090:Coliphages / Q000235:genetics*; D004249:DNA Damage; D004277:DNA, Single-Stranded / Q000187:drug effects* / Q000235:genetics; D004279:DNA, Viral / Q000187:drug effects* / Q000235:genetics; D005821:Genetic Techniques; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology*
D004277:DNA, Single-Stranded; D004279:DNA, Viral; D009838:Oligodeoxyribonucleotides