Purging tumor cells from bone marrow by use of antibody and complement: a critical appraisal.
This review highlighted several problems associated with the use of antibody and complement in the elimination of tumor cells from bone marrow that was to be used for transplantation, and it discussed some of the difficulties encountered in developing this approach in model systems. These problems should be seriously considered by any clinician contemplating this method for bone marrow purging.
Gee
A P
AP
Department of Immunology and Medical Microbiology, College of Medicine, University of Florida, Gainesville 32610.
Boyle
M D
MD
D000906:Antibodies / Q000276:immunology*; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D003165:Complement System Proteins / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D006801:Humans; D009369:Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy
D000906:Antibodies; D003165:Complement System Proteins