Effect of total-body irradiation with bone marrow transplantation on toxicity of cisplatin.
In defined-flora, barrier-maintained rats (WAG/RijMCW males), radiation nephritis is the principal late toxicity seen after high-dose-rate, total-body irradiation (TBI) when hematologic toxicity is prevented by bone marrow transplantation. Pneumonitis develops only if rats are exposed to a conventional environment during and after bone marrow transplantation. Low-dose-rate TBI gives similar toxicity at doses twice as large. Rats surviving for 9 months after TBI show decreased tolerance for cisplatin. This decreased tolerance is related to dose and dose rate and is seen for radiation doses that show little or no renal toxicity. Evidence suggests that the decrease in renal tolerance is due to decreased renal platinum clearance in the irradiated kidneys.
Moulder
J E
JE
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee 53226.
Fish
B L
BL
Holcenberg
J S
JS
Cheng
M
M
D000818:Animals; D016026:Bone Marrow Transplantation; D002945:Cisplatin / Q000493:pharmacokinetics / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D008657:Metabolic Clearance Rate; D011829:Radiation Dosage; D051381:Rats; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D002945:Cisplatin