[Pathogenic aspects of duodenal ulcers by cysteamine. Role of the Brunner glands].
In Wistar rats, the acid factor, the peripheral dopaminergic mechanism and the role of Brunner gland (BG), in the prevention of the Cysteamine duodenal ulcer (CDU) were studied. It was found that Bromocriptine; a peripheral dopaminergic neuronal receptor agonist (DA2), produced prevention of the CDU and blocked of PAS depletion of the BG; in contrast, SCH23390, a peripheral dopaminergic vascular receptor antagonist (DA1), and SAMe, a peripheral and central antidopaminergic; induced aggravation of CDU and total depletion of the BG. In conclusion, the HCl factor, a peripheral dopaminergic mechanism and impaired Brunners gland secretion of PAS mucus, in the pathogenesis of the CDU was postulated.
Laudanno
O M
OM
Catedras de Patología III, Facultad de Medicina, Rosario, Argentina.
Bedini
O A
OA
Cesolari
J A
JA
San Miguel
P
P
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D002011:Brunner Glands / Q000503:physiopathology*; D003543:Cysteamine / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000209:etiology*; D004386:Duodenum / Q000503:physiopathology*; D005260:Female; D005744:Gastric Acid / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D001971:Bromocriptine; D003543:Cysteamine
Aspectos patogénicos en la úlcera duodenal por cisteamina. Rol de las glándulas de Brunner (GB).