title: Treatment of epidural cord compressions from Hodgkin's disease with chemotherapy. A report of two cases and a review of the literature.
abstract: Epidural cord compressions are a frequent and serious problem for patients with cancer. Standard treatment for these lesions includes local irradiation with or without surgery. Herein are reported two cases of epidural cord compression from Hodgkin's disease that responded dramatically to systemic chemotherapy. A review of the literature reveals reports of successful chemotherapy in the treatment of seven patients with epidural metastases secondary to lymphomas and 15 secondary to a variety of other tumors. The use of systemic chemotherapy is an increasingly important therapeutic option for treatment of epidural cord compressions in carefully selected patients.
authors.affiliation: Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland.
authors.forename: P A
authors.initials: PA
authors.lastname: Burch
authors.forename: S A
authors.initials: SA
authors.lastname: Grossman
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D008297:Male; D013117:Spinal Cord Compression / Q000188:drug therapy* / Q000209:etiology*