Nephrotoxicity of continuous intravenous infusion of recombinant interleukin-2.
Adoptive immunotherapy with recombinant interleukin-2 has been complicated by significant nephrotoxicity of uncertain etiology. Creatinine clearance, effective renal plasma flow, plasma renin activity, aldosterone levels, and urinary prostaglandin excretion were evaluated in a 62-year-old man receiving continuous infusion recombinant interleukin-2. There was a marked decrease in the creatinine clearance and renal plasma flow, accompanied by an elevation in plasma renin activity and aldosterone level. Prostaglandin excretion also decreased, implying a direct effect on renal prostaglandin synthesis. The decrease in renal prostaglandin synthesis at a time of increased plasma renin activity may explain the reduction in renal function seen with recombinant interleukin-2 therapy.
Christiansen
N P
NP
Department of Medicine, University of Minnesota Medical School, Minnesota.
Skubitz
K M
KM
Nath
K
K
Ochoa
A
A
Kennedy
B J
BJ
D000450:Aldosterone / Q000097:blood; D003404:Creatinine / Q000378:metabolism; D006801:Humans; D007376:Interleukin-2 / Q000008:administration & dosage / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012079:Renal Circulation / Q000187:drug effects; D012083:Renin / Q000097:blood
D007376:Interleukin-2; D011994:Recombinant Proteins; D000450:Aldosterone; D003404:Creatinine; D012083:Renin