title: Gene sequences coding for S-adenosylmethionine decarboxylase are present on human chromosome 6 and the X and are not amplified in colon neoplasia.
abstract: Sequences for human S-adenosylmethionine decarboxylase, an enzyme involved in polyamine biosynthesis, which is elevated in tumors, have been localized on chromosome 6 and the X.
authors.affiliation: Department of Surgical Oncology, Roswell Park Memorial Institute, New York State Department of Health, Buffalo 14263.
authors.forename: D M
authors.initials: DM
authors.lastname: Radford
authors.forename: R
authors.initials: R
authors.lastname: Eddy
authors.forename: L
authors.initials: L
authors.lastname: Haley
authors.forename: W M
authors.initials: WM
authors.lastname: Henry
authors.forename: A E
authors.initials: AE
authors.lastname: Pegg
authors.forename: A
authors.initials: A
authors.lastname: Pajunen
authors.forename: T B
authors.initials: TB
authors.lastname: Shows
mesh_terms: D012437:Adenosylmethionine Decarboxylase / Q000235:genetics*; D000818:Animals; D002262:Carboxy-Lyases / Q000235:genetics*; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D003110:Colonic Neoplasms / Q000201:enzymology / Q000235:genetics*; D003111:Colonic Polyps / Q000201:enzymology / Q000235:genetics; D015342:DNA Probes; D015252:Deoxyribonucleases, Type II Site-Specific; D005784:Gene Amplification; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D009693:Nucleic Acid Hybridization; D011110:Polymorphism, Genetic; D014960:X Chromosome
chemical_list: D015342:DNA Probes; C024388:CTGCAG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific; D002262:Carboxy-Lyases; D012437:Adenosylmethionine Decarboxylase