New antiparasitic agents. III. Comparison between trypanocidal activities of some acridine derivatives against Trypanosoma cruzi in vitro.
Some acridine compounds referred to as 9-imino, 9-oxo and 9-thio derivatives were screened for activity against Trypanosoma cruzi in vitro. The results are discussed here with reference to the structure of the compounds tested. Attempts to elucidate the mode of action of active acridines are also included. The most active compounds that were tested were 9-thioacridanones and 9-thio-1,2,3,4-tetrahydroacridanones Added to this, the dialkylaminoalkylthio group seems to be the most convenient molecular moiety for trypanocidal activity in the 9-substituted acridine series.
Osuna
A
A
Departamento de Parasitologia, Facultad de Farmacia, Universidad de Granada, Spain.
Ruiz-Perez
L M
LM
Gamarro
F
F
Rodriguez-Santiago
J I
JI
Castanys
S
S
Sharples
D
D
Galy
A M
AM
Giovannageli
G
G
Galy
J P
JP
Soyfer
J C
JC
D000166:Acridines / Q000494:pharmacology*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
D000166:Acridines; D014344:Trypanocidal Agents