title: Subependymal giant-cell astrocytoma in children. An unusual discrepancy between histological and clinical features.
abstract: The authors describe five cases of subependymal giant-cell astrocytoma in children in which many clinical, histological, immunohistochemical, and ultrastructural features typical of this tumor were present. However, prominent focal necrosis and mitoses, features usually associated with high-grade tumors, were seen in all cases. Despite the presence of necrosis and mitoses, clinical follow-up studies have revealed a lack of aggressive tumor behavior after surgery alone. The discrepancy between the histological and clinical features in these cases is emphasized so that excessive treatment of a basically low-grade tumor may be avoided. Mast cells were seen in all five cases, often in large numbers.
authors.affiliation: Department of Anatomical Pathology, Royal Children's Hospital, Melbourne, Australia.
authors.forename: C W
authors.initials: CW
authors.lastname: Chow
authors.forename: G L
authors.initials: GL
authors.lastname: Klug
authors.forename: E A
authors.initials: EA
authors.lastname: Lewis
mesh_terms: D002551:Cerebral Ventricle Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D002648:Child; D002675:Child, Preschool; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005910:Glioma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron
chemical_list: D005904:Glial Fibrillary Acidic Protein