title: Are effects of antihypertensive treatment on lipoproteins merely "side-effects"? A comparison of prazosin and metoprolol.
abstract: Thirty-seven patients with a supine systolic blood pressure greater than 160 and/or a diastolic blood pressure greater than 95 mmHg were enrolled in the study and treated for 6 months with prazosin and 6 months with metoprolol (in random order). Neither the systolic nor the diastolic blood pressures differed after the two types of treatment (median difference 0/0 mmHg). The mean and median differences in serum cholesterol, however, were 0.4 and 0.3 mmol/l respectively, which were 9 and 5% of the pretreatment values. The corresponding differences in the atherogenic index (in which cholesterol in high density lipoproteins is integrated) were 10 and 8% of the pretreatment values. This difference in the metabolic response to the two drugs at the same blood pressure level is most probably of importance in the long-term prevention of ischaemic heart disease, for which high levels of serum cholesterol and atherogenic index are major risk factors.
authors.affiliation: Department of Geriatrics, Uppsala University, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Lithell
authors.forename: K
authors.initials: K
authors.lastname: Haglund
authors.forename: F
authors.initials: F
authors.lastname: Granath
authors.forename: J
authors.initials: J
authors.lastname: Ostman
mesh_terms: D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D011224:Prazosin / Q000627:therapeutic use*; D011897:Random Allocation
chemical_list: D008055:Lipids; D008074:Lipoproteins; D008790:Metoprolol; D011224:Prazosin