Structure of adenosine-5'-mononicotinate (AMN) trihydrate: an analog of NAD for testing intramolecular stacking.
C16H16N6O5.3H2O, Mr = 426.4, monoclinic, P21, a = 9.535 (2), b = 13.932 (2), c = 7.138 (2) A, beta = 93.13 (2) degrees, V = 946.85 A3, Z = 2, Dx = 1.495 g cm-3, lambda (Cu K alpha) = 1.5418 A, mu = 9.93 cm-1, F(000) = 428, T = 294 K, R = 0.045 and wR = 0.059 for 1460 observed reflections [I greater than 3 sigma (I)]. The AMN molecules, unlike NAD or other model structures of NAD, are not charged and exhibit intra- as well as intermolecular stacking of pyridine ring over adenine ring. There is extensive hydrogen bonding in the crystal involving the pyridine and adenine rings and the three water molecules. Rather surprisingly, the ester carbonyl O atom is not involved in the hydrogen bonding.
Ramasubbu
N
N
Center for Crystallographic Research, Roswell Park Memorial Institute, Buffalo, NY 14203.
Parthasarathy
R
R
D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D009243:NAD / Q000031:analogs & derivatives; D014961:X-Ray Diffraction
D009243:NAD; C062207:adenosine-5'-mononicotinate