Effect of combined administration of a prostacyclin analogue and adriamycin against the artificial metastasis of Meth A cell.
Antimetastatic effect of a stable prostacyclin analogue (PGI2-TEI8153) in combination use with adriamycin (ADM) was investigated. Meth A cell, which had membrane protein of 18,000 daltons specifically bound to platelets, induced platelet aggregation dose-dependently. This platelet aggregation was totally suppressed by PGI2-TEI8153. PGI2-TEI8153 also suppressed the pulmonary arrest as well as pulmonary metastasis of Meth A cells. Combined use of PGI2-TEI8153 and ADM exerted much less antimetastatic effect than that with PGI2-TEI8153 alone, indicating the counteracting effect of ADM against the PGI2-TEI8153. However, this combination use brought about additive antimetastatic effects with 2-fold reduction of pulmonary nodules compared to that of ADM alone. Consequently, even the anticancer drug itself has a negative influence on metastasis, the combined use of PGI2-TEI8153 with it is promising for the prevention of metastasis.
Niitsu
Y
Y
Department of Internal Medicine (Section 4), Sapporo Medical College, Japan.
Ishigaki
S
S
Kogawa
K
K
Mogi
Y
Y
Watanabe
N
N
Kohgo
Y
Y
Urushizaki
I
I
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage*; D011464:Epoprostenol / Q000008:administration & dosage*; D005354:Fibrosarcoma / Q000188:drug therapy / Q000556:secondary*; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D010974:Platelet Aggregation
D004317:Doxorubicin; D011464:Epoprostenol