title: Penetration of cefuroxime and ceftazidime into human lungs.
abstract: We have studied the penetration of cefuroxime and ceftazidime into lung tissue of 40 patients subjected to pulmonary surgery. Samples of blood and lung tissue were taken 1 and 2 h after antibiotic administration. Patients were randomly assigned to four dosage schedule groups: group A received a single intravenous injection of 750 mg cefuroxime; the lung tissue levels at 1 and 2 h were 9.6 +/- 3.1 and 4.54 +/- 2.64 micrograms/g of cefuroxime; the percentage penetration from serum into the lung tissue was 33.7 and 34.6%, respectively. Group B patients received three doses of 750 mg cefuroxime; lung tissue levels were 17.1 +/- 7.7 and 14.7 +/- 5.4 micrograms/g, the percentage of penetration being 89.1 and 102.8% at 1 and 2 h. Group C received a single intravenous injection of 1 g ceftazidime; the lung tissue levels were 16.3 +/- 10.1 and 10 +/- 5.04 micrograms/g; the percentage of penetration from serum was 38.3 and 35.3%. Group D received three doses of 1 g ceftazidime; the lung tissue concentrations were 11.98 +/- 7.5 and 8.5 +/- 7.3 micrograms/g and the percentage of penetration 35.1 and 32.2% at 1 and 2 h after last dose.
authors.affiliation: Department of Microbiology, University Hospital, Seville, Spain.
authors.forename: E J
authors.initials: EJ
authors.lastname: Perea
authors.forename: J
authors.initials: J
authors.lastname: Ayarra
authors.forename: M C
authors.initials: MC
authors.lastname: García Iglesias
authors.forename: I
authors.initials: I
authors.lastname: García Luque
authors.forename: J
authors.initials: J
authors.lastname: Loscertales
mesh_terms: D000328:Adult; D000368:Aged; D002442:Ceftazidime / Q000097:blood / Q000493:pharmacokinetics*; D002444:Cefuroxime / Q000097:blood / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation
chemical_list: D002511:Cephalosporins; D002442:Ceftazidime; D002444:Cefuroxime