title: Prognostic significance of estrogen and progesterone receptors in stage II breast cancer.
abstract: Estrogen (ER) and progesterone receptors (PgR) were evaluated in samples from primary tumors in 539 patients with stage II breast cancer participating in a randomized multicenter controlled clinical trial on adjuvant therapy. At the cut-off points of 10 fmol ER/mg protein and 30 fmol PgR/mg protein, no significant difference in recurrence-free survival (RFS) existed between premenopausal patients with receptor-positive and negative tumors, respectively. After recurrence, premenopausal patients with receptor-positive tumors had a significant longer survival than patients with receptor-negative tumors. In postmenopausal patients not treated with adjuvant tamoxifen, no correlations between RFS and receptor status were found. Patients with ER+ tumors survived longer than patients with ER-tumors. In postmenopausal patients treated with adjuvant tamoxifen, highly significant differences in RFS and in survival were observed when receptor-positive patients were compared with receptor-negative patients. No differences in survival after recurrence were registered among these patients.
authors.affiliation: Department of Surgery, University Hospital, Lund, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Rydén
authors.forename: M
authors.initials: M
authors.lastname: Fernö
authors.forename: A
authors.initials: A
authors.lastname: Borg
authors.forename: L
authors.initials: L
authors.lastname: Hafström
authors.forename: T
authors.initials: T
authors.lastname: Möller
authors.forename: A
authors.initials: A
authors.lastname: Norgren
mesh_terms: D001943:Breast Neoplasms / Q000032:analysis* / Q000401:mortality / Q000628:therapy; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008593:Menopause; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D011897:Random Allocation; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone