Immunological factors influencing liver graft survival.
Donor-recipient ABO blood group mismatching is associated with a decreased graft survival rate in liver transplantation. We have been unable to demonstrate an effect of high levels of panel reactive antibody or a positive donor-specific cytotoxic antibody cross-match on graft survival. A limited analysis of HLA-matching for the A, B, and DR loci suggests a paradoxical effect, but much more experience is needed before the true effect of HLA matching on graft outcome can be reliably evaluated.
Gordon
R D
RD
Department of Surgery and Pathology, University of Pittsburgh, PA.
Fung
J J
JJ
Iwatsuki
S
S
Duquesnoy
R J
RJ
Starzl
T E
TE
D000017:ABO Blood-Group System / Q000276:immunology; D006084:Graft Rejection; D006085:Graft Survival; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D016031:Liver Transplantation
D000017:ABO Blood-Group System; D006680:HLA Antigens