Population pharmacokinetics of gentamicin in neonates.
The influence of a number of clinical characteristics on the population pharmacokinetics of gentamicin were examined using routine drug-monitoring data from a group of 113 neonates. The data were analyzed using the programme NONMEM. Clearance was 0.053 litres.h-1.kg-1 and was reduced in neonates with postconceptional age less than or equal to 34 weeks (X 0.83) and 5-min Apgar score less than 7 (X 0.82). Volume of distribution was 0.47 litres.kg-1. These population mean parameter estimates were used to generate dosage regimens to achieve concentrations within the therapeutic range.
Thomson
A H
AH
Department of Materia Medica, University of Glasgow, UK.
Way
S
S
Bryson
S M
SM
McGovern
E M
EM
Kelman
A W
AW
Whiting
B
B
D000375:Aging / Q000378:metabolism; D001034:Apgar Score; D005260:Female; D005839:Gentamicins / Q000493:pharmacokinetics*; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D008297:Male
D005839:Gentamicins