Serum levels and urinary excretion of beta-2-microglobulin in patients with urinary bladder carcinoma.
The levels of beta 2-microglobulin in urine and serum were determined in 34 patients with urinary bladder carcinoma. In 22 patients (64%) serum beta 2-microglobulin was elevated and in 11 patients (32%) urinary excretion of the protein was increased. It was also found that all but 1 patient with elevated serum beta 2-microglobulin or urinary beta 2-microglobulin had WHO grade-II or grade-III tumors. In contrast, all patients with grade-I tumors, except 1, displayed normal levels of urine and serum beta 2-microglobulin.
Engström
W
W
Department of Tumor Pathology, Karolinska Hospital, Stockholm, Sweden.
D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000378:metabolism*; D006801:Humans; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*; D001613:beta 2-Microglobulin / Q000378:metabolism*
D014408:Biomarkers, Tumor; D001613:beta 2-Microglobulin