title: The fate of the circumsporozoite antigens during the exoerythrocytic stage of Plasmodium berghei.
abstract: There has been considerable interest in the circumsporozoite proteins due to their potential use in anti-malarial vaccines. Previous authors have shown that these proteins persist from the invading sporozoite throughout the growing exoerythrocytic or liver stage. We show that the different distributions of these proteins seen during the development of the exoerythrocytic parasite of Plasmodium berghei closely follow morphological changes, which can be recognized under the light microscope. At the end of the exoerythrocytic cycle, the majority of the remaining circumsporozoite proteins were associated with the spongy stroma in which the emerging exoerythrocytic merozoites lay. Cell-mediated immunity originally directed against sporozoites might recognize the stroma as a second target resulting in the indirect destruction of the exoerythrocytic merozoites.
authors.affiliation: Department of Pure and Applied Biology, Imperial College, London/United Kingdom.
authors.forename: A
authors.initials: A
authors.lastname: Suhrbier
authors.forename: A J
authors.initials: AJ
authors.lastname: Hamilton
authors.forename: J
authors.initials: J
authors.lastname: Nicholas
authors.forename: R E
authors.initials: RE
authors.lastname: Sinden
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D002460:Cell Line; D004912:Erythrocytes / Q000469:parasitology*; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D010962:Plasmodium berghei / Q000254:growth & development* / Q000648:ultrastructure; D015800:Protozoan Proteins
chemical_list: D000953:Antigens, Protozoan; D000954:Antigens, Surface; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan