Quantifying genotoxicity and non-genotoxicity.
Since the ability to induce genotoxicity is often equated with the potential for initiating the carcinogenic process, a method for quantitating genotoxicity would provide a useful measure for this potential. It is demonstrated herein that CPBS, the Carcinogenicity Prediction and Battery Selection method, provides a useful quantitative measure of genotoxicity as well as allowing for the detailed evaluation of the performance of batteries of short-term tests in order to select those predictive of carcinogenic potential.
Rosenkranz
H S
HS
Department of Environmental Health Sciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106.
Ennever
F K
FK
D000818:Animals; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic; D002869:Chromosome Aberrations; D004249:DNA Damage; D004260:DNA Repair; D066298:In Vitro Techniques; D009152:Mutagenicity Tests / Q000592:standards*; D009153:Mutagens; D011336:Probability; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012854:Sister Chromatid Exchange; D013997:Time Factors
D002273:Carcinogens; D009153:Mutagens