Immunization of dogs with a Leishmania infantum-derived vaccine.
A partially-purified extract of Leishmania infantum has been administered to healthy dogs. Post-immunization sera were found to neutralize the infectivity of L. infantum and to abate the development of L. major. Muramyl dipeptide and one of its derivates, murabutide, were the best adjuvants.
Ogunkolade
B W
BW
Department of Tropical Medicine, Pitié-Salpétrière School of Medicine, Paris, France.
Vouldoukis
I
I
Frommel
D
D
Davoust
B
B
Rhodes-Feuillette
A
A
Monjour
L
L
D000276:Adjuvants, Immunologic; D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis*; D004283:Dog Diseases / Q000517:prevention & control; D004285:Dogs; D005260:Female; D005455:Fluorescent Antibody Technique; D005620:Freund's Adjuvant / Q000009:adverse effects; D007114:Immunization / Q000662:veterinary*; D007118:Immunoassay; D007893:Leishmania donovani / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000517:prevention & control / Q000662:veterinary; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012510:Sarcoma 180; D014407:Tumor Cells, Cultured; D014612:Vaccines / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000913:Antibodies, Protozoan; D014612:Vaccines; D005620:Freund's Adjuvant