[Characterization and evaluation of the pathogenic nature of duodenogastric reflux by measurement of intragastric choline and sialic acid in normal subjects and in patients with duodenal ulcer].
The high choline content in pancreatic juice and bile-contaminated gastric juice samples suggested that intragastric choline content could be related to duodenogastric reflux (DGR). In 308 secretory tests in normal subjects (38) and in duodenal ulcer patients (DU) (270), acid, pepsin, sialic acid and choline outputs were measured in basal secretion and after pentagastrin, insulin or secretin modulation. The distribution of choline output values in basal secretion showed that 77% subjects had no or small choline amounts (less than 10 mumol/h) and another population had high output values (greater than or equal to 10 mumol/h). Choline hourly outputs greater than or equal to 10 mumol/h could be related with positive DGR. DGR did not seem to modify acid or pepsin secretion except if acid outputs were low: in these cases the neutralizing activity reduced acid outputs and resulted in a pepsin inactivation. DGR by itself increased sialic acid outputs as evidenced by mucus erosion. In normal subjects, weak mucus erosion might be due to proteolytic activity. In DU patients without DGR, erosion was increased but was due to the same mechanism. In DU patients with DGR, erosion was stronger and no relationship with proteolytic activity could be established because of the introduction of eroded duodenal glycoprotein into the stomach. Pentagastrin, insulin and secretin were able to induce DGR. Reflux could contribute to mucus erosion either by its detersive properties or by the proteolytic material coming from the pancreas.
Vatier
J
J
INSERM U-10, Unité de Recherche de Gastroentérologie, CHU Xavier-Bichat, Paris.
Poitevin
C
C
Vitré
M T
MT
Mignon
M
M
D000328:Adult; D002794:Choline / Q000378:metabolism* / Q000502:physiology; D004381:Duodenal Ulcer / Q000150:complications* / Q000378:metabolism; D004383:Duodenogastric Reflux / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D012633:Secretin / Q000494:pharmacology; D012794:Sialic Acids / Q000378:metabolism*
D007328:Insulin; D012794:Sialic Acids; D012633:Secretin; D002794:Choline
Caractérisation et évaluation du caractère pathogène du reflux duodénogastrique par la mesure de la choline et de l'acide sialique intragastriques chez le sujet normal et l'ulcéreux duodénal.