New vistas in chronic schizophrenia.
In view of the distinct possibility that the disturbed glucose regulation in the frontal area and basal ganglia of chronic schizophrenia is very germane to the successful treatment of this condition, a survey is given of the many factors that have to be considered in developing a therapy that takes into account this new information. The suggestion is made that the balance between cAMP and cGMP in the cells affected are dysregulated so that there is an excessive activity of the cAMP generating system which eventually leads to the pathological picture found in this condition. To restore the normal metabolic balance, use will have to be made of the various substances that are known to enhance the cGMP generating system in the cell, thereby restoring a more normal metabolic integrity. In this connection, the use of high doses of insulin under cover of hyperglycaemia and also the addition of D-ribose could become the cornerstone of a series of treatments to enhance the action of currently used medications in this often intractable illness.
Lichtigfeld
F
F
South African Brain Research Institute, Johannesburg.
Sandyk
R
R
Gillman
M
M
D000208:Acute Disease; D001921:Brain / Q000378:metabolism*; D002908:Chronic Disease; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D012559:Schizophrenia / Q000378:metabolism*
D005947:Glucose