title: Changes in phosphate do not affect insulin release from isolated mouse islets of Langerhans.
abstract: Phosphate affects glucose tolerance, insulin release and peripheral insulin sensitivity. In the present study moderate changes in the phosphate concentration of the incubation medium from 0.3 to 2 mmol/l (i.e., within the physiological range) did not affect insulin release from isolated mouse islets in vitro. In addition, the vitamin-D status of the animals had no effect on the glucose-stimulated insulin response in the different phosphate concentrations. Therefore these data indicate that the impaired glucose tolerance seen in hypophosphatemic states is not due to a direct effect of phosphorus levels on the insulin-releasing B-cell.
authors.affiliation: Department of Histology and Cell Biology, University of Umeå, Sweden.
authors.forename: B J
authors.initials: BJ
authors.lastname: Frankel
authors.forename: S
authors.initials: S
authors.lastname: Sjunghall
mesh_terms: D000818:Animals; D002117:Calcitriol / Q000627:therapeutic use; D005260:Female; D007328:Insulin / Q000378:metabolism*; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D010710:Phosphates / Q000494:pharmacology*; D014808:Vitamin D Deficiency / Q000378:metabolism
chemical_list: D007328:Insulin; D010710:Phosphates; D002117:Calcitriol