Effect of desipramine treatment on 3H-imipramine binding in the blood platelets of depressed patients.
Platelet imipramine binding (IB) was studied in depressed patients before and after treatment with desipramine for 17-28 days. Administration of desipramine was associated with a significant increase in Bmax. There was a trend for an increase in Kd, but it did not reach statistical significance. The net result of the changes in Bmax and Kd was an increase in IB. There were significant correlations between the change in depression ratings and pretreatment Kd, as well as the change in Kd during treatment. These results suggest that decreased IB is not a trait-dependent marker, but a state-dependent marker for depression.
Arora
R C
RC
Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.
Meltzer
H Y
HY
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy*; D003891:Desipramine / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014316:Tritium
D014316:Tritium; D003891:Desipramine