title: [Effect of prostaglandins I2 and E1 on the cholesterol level in cultured smooth muscle cells from the human aorta].
abstract: Prostaglandins I2(PGI2) and E1(PGE1) (5 X 10(-7) M) reduced by 30% the content of intracellular cholesterol in cultured human aorta smooth muscle cells after 24 hrs of incubation in a medium without fetal calf serum. Total HDL, as well as HDL3 and HDL2b fractions stimulated the effect of prostaglandins on the reduction (by 50%) of cholesterol level.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Shakhov
authors.forename: J M
authors.initials: JM
authors.lastname: Lamaziere
authors.forename: B
authors.initials: B
authors.lastname: Dorian
authors.forename: D
authors.initials: D
authors.lastname: Daret
authors.forename: J
authors.initials: J
authors.lastname: Larrue
mesh_terms: D000328:Adult; D000527:Alprostadil / Q000494:pharmacology*; D001013:Aorta, Thoracic / Q000378:metabolism; D002478:Cells, Cultured; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D011464:Epoprostenol / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*
chemical_list: D008075:Lipoproteins, HDL; D002784:Cholesterol; D011464:Epoprostenol; D000527:Alprostadil
vernacular_title: Vliianie prostaglandinov I2 i E1 na soderzhanie kholesterina v kul'ture gladkomyshechnykh kletok aorty cheloveka.