title: The effect on the blood-brain barrier of intracarotid contrast media--iopamidol and diatrizoate.
abstract: The effect on the blood-brain barrier (BBB) was assessed following intracarotid injection of iopamidol (300 mgI/ml.), meglumine diatrizoate (305 mgI/ml.) and isotonic saline. Four ml/kg of 2% Evans blue solution and 0.1 mCi 99m Technetium-DTPA (Tc-DTPA) were used as tracers. No blue staining was observed in the saline group. Three out of 10 animals showed blue staining in the iopamidol group. All ten animals showed blue staining in the diatrizoate group. There were statistical differences between the diatrizoate and the other two groups. Tc-DTPA extravasation was 0.37 +/- 0.13 (mean +/- SD) in the saline group, 1.29 +/- 0.77 in the iopamidol group and 3.88 +/- 1.67 in the diatrizoate group. Statistical differences were observed among three groups. These observations suggest that Tc-DTPA is very sensitive in detecting a subtle BBB injury and that iopamidol had a significantly smaller effect on the BBB than did meglumine diatrizoate.
authors.affiliation: Department of Radiology Fukui Medical School.
authors.forename: K
authors.initials: K
authors.lastname: Hayakawa
authors.forename: R
authors.initials: R
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Ishii
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002339:Carotid Arteries; D003974:Diatrizoate Meglumine / Q000633:toxicity*; D005260:Female; D007269:Injections, Intra-Arterial; D007479:Iopamidol / Q000633:toxicity*; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011817:Rabbits; D013667:Technetium; D016284:Technetium Tc 99m Pentetate
chemical_list: D009942:Organometallic Compounds; D003974:Diatrizoate Meglumine; D013667:Technetium; D004369:Pentetic Acid; D007479:Iopamidol; D016284:Technetium Tc 99m Pentetate