Clinical and autoantibody correlations in Orientals with systemic lupus erythematosus.
Serum samples from 94 patients with systemic lupus erythematosus (SLE) from a medical unit in Singapore were analysed for autoantibodies of 10 different specificities. The prevalence of antibodies to the following antigens was as follows: double stranded (ds) DNA (43%), histone (81%), Sm (26%), nuclear ribonuclear protein (nRNP) (32%), SS-A(Ro) (63%), SS-B(La) (12%), SL/Ki (9%), ribosomal RNP (rRNP) (16%), p70/p80 (5%), proliferating cell nuclear antigen (PCNA) (3%). Except for a higher prevalence of anti-SS-A(Ro), other autoantibodies were within the range reported from Western countries, indicating a high uniformity of autoantibody profiles in SLE in different countries. Patients with neuropsychiatric manifestations showed a higher plurality of antibodies per patient than patients without neuropsychiatric symptoms, 4.22 v 2.77. Patients with anti-Sm were more likely to have active lupus disease. There was no increased prevalence or specific type of autoantibody in those with renal manifestations.
Boey
M L
ML
Department of Medicine IV, Tan Tock Seng Hospital, Singapore.
Peebles
C L
CL
Tsay
G
G
Feng
P H
PH
Tan
E M
EM
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology; D002493:Central Nervous System Diseases / Q000276:immunology; D002681:China / Q000208:ethnology; D004247:DNA / Q000276:immunology; D005260:Female; D006657:Histones / Q000276:immunology; D006801:Humans; D007194:India / Q000208:ethnology; D008180:Lupus Erythematosus, Systemic / Q000208:ethnology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D017411:Ribonucleoproteins, Small Nuclear; D012846:Singapore; D055517:snRNP Core Proteins; D000099207:SS-A Antigen
D000974:Antibodies, Antinuclear; D001324:Autoantigens; D004247:DNA; D006657:Histones; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D017411:Ribonucleoproteins, Small Nuclear; D055517:snRNP Core Proteins; D000099207:SS-A Antigen; C116006:RO60 protein, human