Immunoglobulin gene rearrangement and its implications for the study of B-cell neoplasia.
Molecular biologic investigation of the process of immunoglobulin gene rearrangement has elucidated the mechanism of immunologic diversification and has provided essential tools for the study of B-cell neoplasia. The use of immunoglobulin gene probes has permitted a clearer understanding of B-cell malignancies, but has also raised new questions and pointed out new directions for ultimately clarifying the mechanism of B-cell transformation. Thus, we have a difficult challenge ahead, but with our present knowledge, we are in a better position than ever to address critical issues relating to the genesis of lymphoid neoplasia.
Pugh
W C
WC
University of Texas System Cancer Center, Houston.
Stass
S A
SA
D000818:Animals; D001402:B-Lymphocytes / Q000648:ultrastructure; D002454:Cell Differentiation; D005803:Genes, Immunoglobulin; D005812:Genes, Switch; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics*