title: [Clinical use of the artificial heart, indications and results].
abstract: Clinical experience with the artificial heart now comprises 520 cases. 390 patients had to be supported mechanically when they could not be weaned off cardiopulmonary bypass. 177 (45%) subsequently had their assist devices removed and 100 (25.4%) were discharged. Good functional results were achieved, since 30 of 36 long-term survivors are in NYHA class I or II. 140 underwent two-stage cardiac transplantation. Of 63 patients implanted with a ventricular assist device (VAD) 71% were transplanted and 51% survived. A total artificial heart (TAH) was used in 77 cases, 81% were transplanted and 47% survived. Five patients received TAH implantations as a permanent replacement of the failing heart. Though the clinical courses were complicated by strokes and infections and the patients were tethered to bulky drive units, it was proven that the TAH may sustain human life for up to 622 days, much longer than so far achieved in animal experiments. Improvements of the atrial connectors and valve holding components and of the biocompatibility of the blood contacting surfaces should overcome the complication of thromboembolism. Fully implantable devices which are currently being developed will avoid the problem of drive-line infections and provide fuller mobility to the patient.
authors.affiliation: II. Chirurgische Universitätsklinik, Wien.
authors.forename: A
authors.initials: A
authors.lastname: Moritz
authors.forename: E
authors.initials: E
authors.lastname: Wolner
authors.forename: Y
authors.initials: Y
authors.lastname: Nose
mesh_terms: D001243:Assisted Circulation; D006333:Heart Failure / Q000628:therapy*; D016027:Heart Transplantation; D006354:Heart, Artificial; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans
vernacular_title: Die klinische Anwendung des künstlichen Herzens, Indikationen und Ergebnisse.