title: Total insulin levels in type 1 diabetic patients with insulin antibodies and their effect on insulin requirement and metabolic control.
abstract: In 158 type 1 diabetic patients the relations between insulin antibodies and total insulin and between total insulin and insulin requirement, mean blood glucose, post-prandial change in blood glucose, mean deviation factor of blood glucose, M-value and frequency of hypoglycemias were investigated. Forty-eight patients were antibody negative (antibody level less than or equal to 0.4%) and 110 patients had various levels of insulin antibodies and elevated levels of total insulin, but not of free insulin. After having made all necessary efforts to stabilize metabolism, parameters of metabolic control were determined. No effect of the elevated total insulin levels in patients with insulin antibodies could be demonstrated on insulin requirement, mean blood glucose, postprandial rise in blood glucose, mean deviation factor of blood glucose and M-value. The efforts needed to reach acceptable blood glucose levels were not greater in patients with elevated total insulin. The frequency of hypoglycemias during the night was increased in patients with total insulin levels higher than 2 mmol/l which, although not statistically significant, may be of clinical relevance.
authors.affiliation: Diabetes Research Institute, Düsseldorf, FRG.
authors.forename: A
authors.initials: A
authors.lastname: Hübinger
authors.forename: A
authors.initials: A
authors.lastname: Becker
authors.forename: F A
authors.initials: FA
authors.lastname: Gries
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002940:Circadian Rhythm / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007003:Hypoglycemia / Q000453:epidemiology; D007328:Insulin / Q000097:blood* / Q000494:pharmacology / Q000627:therapeutic use; D007330:Insulin Antibodies / Q000276:immunology*; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007330:Insulin Antibodies