title: Anticentromere antibodies--clinical correlates.
abstract: We tested 11,594 consecutive sera for antinuclear antibodies and 1,502 were found to be positive; 68 patients (72 sera) had anticentromere antibodies. A retrospective analysis of the clinical characteristics and diagnoses of patients found to have anticentromere antibodies were correlated and showed a diverse array of findings. The association of anticentromere antibodies and the CREST variant of scleroderma may be less specific than originally thought when used as a screening test in an unselected population with rheumatic disease. Anticentromere antibody was present in patients with drug induced lupus, a finding not previously reported.
authors.affiliation: Department of Rheumatology/Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: J P
authors.initials: JP
authors.lastname: Wade
authors.forename: B
authors.initials: B
authors.lastname: Sack
authors.forename: P H
authors.initials: PH
authors.lastname: Schur
mesh_terms: D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis*; D002503:Centromere / Q000276:immunology*; D002875:Chromosomes / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012216:Rheumatic Diseases / Q000175:diagnosis / Q000276:immunology*; D012595:Scleroderma, Systemic / Q000175:diagnosis / Q000276:immunology*; D013577:Syndrome
chemical_list: D000974:Antibodies, Antinuclear