Anti-inflammatory and peripheral analgesic activity of esculetin in vivo.
Esculetin determined a reduction in oedema and granulocyte infiltration in the Croton oil ear test in vivo. The drug was able to inhibit Acethylcholine-writhing test and showed a LD50 of 1450 mg/kg i.p. and greater than 2000 mg/kg by mouth. In our experimental conditions, esculetin has an anti-inflammatory and analgesic effect.
Tubaro
A
A
Institute of Pharmacology and Pharmacognosy, University of Trieste, Italy.
Del Negro
P
P
Ragazzi
E
E
Zampiron
S
S
Della Loggia
R
R
D000109:Acetylcholine / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity; D003436:Croton Oil / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010544:Peroxidases / Q000378:metabolism; D014468:Umbelliferones / Q000494:pharmacology* / Q000633:toxicity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014468:Umbelliferones; D003436:Croton Oil; D010544:Peroxidases; D000109:Acetylcholine; C007628:esculetin