Monoamine oxidase inhibitors and anaesthesia. A review.
There has been a recent renewal of interest in the use of monoamine oxidase inhibitors in psychiatry. The concurrent administration of anaesthetic agents, particularly narcotic analgesics, is often a cause for concern. Although many monoamine oxidase inhibitor-drug interactions have been reported, in practice it is only the interaction with pethidine which has led to fatalities. What is not appreciated is that the monoamine oxidase inhibitor-pethidine interaction has two distinct forms-"excitatory" and "depressive". It is this lack of appreciation that has led to much confusion when dealing with patients taking monoamine oxidase inhibitors.
Stack
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CG
Shackleton Department of Anaesthetics, Southampton General Hospital.
Rogers
P
P
Linter
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SP
D000758:Anesthesia; D000777:Anesthetics / Q000009:adverse effects; D004347:Drug Interactions; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects*
D000777:Anesthetics; D008996:Monoamine Oxidase Inhibitors