An open trial of maprotiline for the treatment of cocaine abuse: a pilot study.
Eleven consecutive severe cocaine abusers were treated openly with maprotiline. Nine completed a 7-week trial, and eight maintained abstinence for at least 1 month as outpatients. Treatment compliance and response appeared better than for a similar group of subjects treated without antidepressants.
Brotman
A W
AW
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston 02114.
Witkie
S M
SM
Gelenberg
A J
AJ
Falk
W E
WE
Wojcik
J
J
Leahy
L
L
D000328:Adult; D000873:Anthracenes / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003042:Cocaine; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008376:Maprotiline / Q000008:administration & dosage / Q000627:therapeutic use*; D010349:Patient Compliance; D010865:Pilot Projects; D012189:Retrospective Studies; D019966:Substance-Related Disorders / Q000188:drug therapy*
D000873:Anthracenes; D008376:Maprotiline; D003042:Cocaine