Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient.
A patient with Type 1 (insulin-dependent) diabetes mellitus developed localised amyloidosis at the sites of his injections of porcine insulin. A major amyloid fibril protein was extracted and, by means of its amino acid composition and amino acid sequence, it was shown to contain intact insulin molecules. Porcine insulin is the tenth protein and the first foreign protein to be chemically identified in human amyloid fibrils.
Dische
F E
FE
Department of Morbid Anatomy, King's College School of Medicine and Dentistry, London, UK.
Wernstedt
C
C
Westermark
G T
GT
Westermark
P
P
Pepys
M B
MB
Rennie
J A
JA
Gilbey
S G
SG
Watkins
P J
PJ
D000328:Adult; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000682:Amyloid / Q000302:isolation & purification*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D012867:Skin / Q000187:drug effects / Q000473:pathology*
D000596:Amino Acids; D000682:Amyloid; D007328:Insulin