title: Immunological factors influencing liver graft survival.
abstract: Donor-recipient ABO blood group mismatching is associated with a decreased graft survival rate in liver transplantation. We have been unable to demonstrate an effect of high levels of panel reactive antibody or a positive donor-specific cytotoxic antibody cross-match on graft survival. A limited analysis of HLA-matching for the A, B, and DR loci suggests a paradoxical effect, but much more experience is needed before the true effect of HLA matching on graft outcome can be reliably evaluated.
authors.affiliation: Department of Surgery and Pathology, University of Pittsburgh, PA.
authors.forename: R D
authors.initials: RD
authors.lastname: Gordon
authors.forename: J J
authors.initials: JJ
authors.lastname: Fung
authors.forename: S
authors.initials: S
authors.lastname: Iwatsuki
authors.forename: R J
authors.initials: RJ
authors.lastname: Duquesnoy
authors.forename: T E
authors.initials: TE
authors.lastname: Starzl
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology; D006084:Graft Rejection; D006085:Graft Survival; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D016031:Liver Transplantation
chemical_list: D000017:ABO Blood-Group System; D006680:HLA Antigens