title: High-dose therapy and autologous bone marrow transplantation in partial remission after first-line induction therapy for diffuse non-Hodgkin's lymphoma.
abstract: Seventeen patients received high-dose therapy with autologous bone marrow transplantation (ABMT) when in partial response after induction therapy. There were 11 children and six adults between 3 and 57 years old. Twelve patients were determined to have high-grade lymphoma (ten Burkitt's and two lymphoblastic), and five had intermediate-grade diffuse lymphoma. Ten patients had surgically proven active disease in the abdomen, two had active disease in the bone marrow, and five persistent neurological symptoms. The time interval between diagnosis and ABMT was 2-10 months (median 4 months). Two patients died of progressive disease and two others died while in complete remission (CR) because of toxicity. Thirteen of 17 are still alive and disease free with a median observation time of 2 years. Morbidity was high with 6/17 life threatening reversible complications but overall survival is 75% at 24 months in a group of patients clearly defined as having a very bad prognosis in previous studies.
authors.affiliation: Bone Marrow Transplant Unit, Centre Leon Berard, Lyon, France.
authors.forename: T
authors.initials: T
authors.lastname: Philip
authors.forename: O
authors.initials: O
authors.lastname: Hartmann
authors.forename: P
authors.initials: P
authors.lastname: Biron
authors.forename: J Y
authors.initials: JY
authors.lastname: Cahn
authors.forename: F
authors.initials: F
authors.lastname: Pein
authors.forename: P
authors.initials: P
authors.lastname: Bordigoni
authors.forename: G
authors.initials: G
authors.lastname: Souillet
authors.forename: M
authors.initials: M
authors.lastname: Gartner
authors.forename: C
authors.initials: C
authors.lastname: Lasset
authors.forename: F
authors.initials: F
authors.lastname: Chauvin
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012074:Remission Induction