title: The role of epsilon-aminocaproic acid in reducing bleeding after cardiac operation: a double-blind randomized study.
abstract: Sixty patients scheduled for elective coronary artery bypass graft operations were randomly assigned to receive epsilon-aminocaproic acid or placebo to test whether antifibrinolytic therapy would decrease postoperative bleeding. A small but significant decrease in bleeding was observed in the treated group without complications resulting from treatment with epsilon-aminocaproic acid.
authors.affiliation: Department of Surgery, University of Massachusetts Medical Center, Worcester 01655.
authors.forename: T J
authors.initials: TJ
authors.lastname: Vander Salm
authors.forename: J E
authors.initials: JE
authors.lastname: Ansell
authors.forename: O N
authors.initials: ON
authors.lastname: Okike
authors.forename: T H
authors.initials: TH
authors.lastname: Marsicano
authors.forename: R
authors.initials: R
authors.lastname: Lew
authors.forename: W P
authors.initials: WP
authors.lastname: Stephenson
authors.forename: K
authors.initials: K
authors.lastname: Rooney
mesh_terms: D000614:Aminocaproates / Q000627:therapeutic use*; D015119:Aminocaproic Acid / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D001026:Coronary Artery Bypass; D004311:Double-Blind Method; D005260:Female; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011183:Postoperative Complications / Q000517:prevention & control*; D011897:Random Allocation
chemical_list: D000614:Aminocaproates; D015119:Aminocaproic Acid