[Preoperative nonspecific immunostimulation with Propionibacterium granulosum KP-45 in patients with colorectal cancer. A prospective randomized study].
The effect of preoperative unspecific immunomodulation with Propionibacterium granulosum KP-45 (P.g.) on postoperative complications and patient survival was evaluated in a prospectively randomized trial in patients with colorectal tumor resection. Patients of the therapy group (n = 51) received at least 3 days before operation an infusion of 10 mg P.g., patients of the control group (n = 49) were not treated at all. The wound infection rate and the number of re-explorations were significantly lower in the therapy group, however, patient survival and tumor recurrence rates were not positively affected by this P.g. pre-treatment.
Grundmann
R
R
Chirurgische Universitätsklinik Köln-Lindenthal, Universität zu Köln.
Weber
F
F
Kluger
J
J
Wienand
P
P
Pulverer
G
G
D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000276:immunology; D011424:Propionibacterium / Q000276:immunology*; D011897:Random Allocation; D012004:Rectal Neoplasms / Q000601:surgery / Q000628:therapy*; D013530:Surgical Wound Infection / Q000276:immunology; D014945:Wound Healing
Präoperative unspezifische Immunstimulation mit Propionibacterium granulosum KP-45 bei Patienten mit colorectalem Carcinom. Eine prospektiv randomisierte Studie.