Interpretation of DNA vibration modes. II--The adenosine and thymidine residues involved in oligonucleotides and polynucleotides.
Normal coordinate analysis of the adenosine and thymidine residues involved in the right- and left-handed conformations of oligonucleotides and polynucleotides has been performed. The valence force field, employed in this work, allowed recently to reproduce the vibrational spectra of 2'-deoxythymidine and 2'-deoxyadenosine. The calculated wavenumbers based on a non-redundant set of internal coordinates have been compared to the Raman and infrared peak positions arising from A, B, C, D and Z conformations, in the 1550-1250 cm-1 and 800-600 cm-1 spectral regions: i.e. characteristic of adenosine and thymidine residues. Moreover, a systematic study has been performed on the evolution of the vibrational wavenumbers as a function of the glycosidic angle (chi) and the sugar pucker conformation.
Letellier
R
R
Laboratoire de Spectroscopie Biomoléculaire, U.F.R. Biomédicale de Bobigny, Université Paris XIII, France.
Ghomi
M
M
Taillandier
E
E
D000241:Adenosine; D004247:DNA; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides; D011119:Polynucleotides; D013059:Spectrum Analysis, Raman; D013936:Thymidine; D014732:Vibration
D009841:Oligonucleotides; D011119:Polynucleotides; D004247:DNA; D000241:Adenosine; D013936:Thymidine