Production of interleukin 1 in the joint during the development of antigen-induced arthritis in the rabbit.
Antigen-induced arthritis in the rabbit closely resembles rheumatoid arthritis. The levels of interleukin 1 (IL-1) in the synovial fluid and the synthesis of IL-1 by infiltrating cells in synovial fluid and by the synovial lining from control and inflamed joints has been assessed during the first month of this disease. A number of biological assays have been used to measure rabbit IL-1. Of these, only the assay using the murine thymoma cell line (EL-4 NOB-1) was able to detect IL-1 activity in the synovial fluid of arthritic joints, which was present only in the very early lesion. The leucocytes infiltrating the synovial cavity produced little IL-1 ex vivo in the acute lesion but released large amounts when arthritis was established. A similar finding was made with respect to the production of IL-1 by the synovial lining.
Henderson
B
B
Pharmacology Department, Wellcome Research Laboratories, Beckenham, UK.
Rowe
F M
FM
Bird
C R
CR
Gearing
A J
AJ
D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000276:immunology*; D001681:Biological Assay; D002478:Cells, Cultured; D007375:Interleukin-1 / Q000096:biosynthesis*; D007962:Leukocytes / Q000276:immunology; D008297:Male; D011817:Rabbits; D013582:Synovial Fluid / Q000378:metabolism; D013583:Synovial Membrane / Q000378:metabolism; D013997:Time Factors
D007375:Interleukin-1