title: MR contrast enhancement of intracranial lesions with Gd-DTPA.
abstract: Gd-DTPA is a paramagnetic contrast agent for MR that produces enhancement of lesions on T1-weighted images. Since it does not cross the intact blood-brain barrier (BBB), Gd-DTPA enhances only those pathologic processes that are associated with breakdown of the BBB and structures or lesions that are devoid of a BBB. Gd-DTPA improves conspicuity, helps characterize and delineate the extent of lesions, and increases the sensitivity for detection of cerebral abnormalities.
authors.affiliation: University of California School of Medicine, San Diego.
authors.forename: J R
authors.initials: JR
authors.lastname: Hesselink
authors.forename: G A
authors.initials: GA
authors.lastname: Press
mesh_terms: D001927:Brain Diseases / Q000175:diagnosis*; D003287:Contrast Media / Q000009:adverse effects / Q000493:pharmacokinetics; D005682:Gadolinium / Q000009:adverse effects; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000009:adverse effects / Q000493:pharmacokinetics; D004369:Pentetic Acid / Q000009:adverse effects / Q000493:pharmacokinetics
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA