Selectivity of CF and 5-fluorouracil: critical role of polyglutamylation.
Houghton
J A
JA
Department of Biochemical and Clinical Pharmacology, St. Jude Children's Research Hospital, Memphis, TN 38101.
Williams
L G
LG
deGraaf
S S
SS
Radparvar
S
S
Wainer
I W
IW
Rodman
J R
JR
Houghton
P J
PJ
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000201:enzymology; D000818:Animals; D002460:Cell Line; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D005472:Fluorouracil / Q000627:therapeutic use*; D005492:Folic Acid / Q000031:analogs & derivatives*; D006801:Humans; D002955:Leucovorin / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051379:Mice; D009368:Neoplasm Transplantation; D011624:Pteroylpolyglutamic Acids / Q000378:metabolism*; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D014183:Transplantation, Heterologous
D011624:Pteroylpolyglutamic Acids; D005492:Folic Acid; D013940:Thymidylate Synthase; D002955:Leucovorin; D005472:Fluorouracil