title: The evolution and outcome of cavitating periventricular leukomalacia in infancy. A study of 46 cases.
abstract: Forty six infants with the ultrasonic diagnosis of cavitating periventricular leukomalacia (CPVL) have been reviewed. Follow up examination results allow correlation between the ultrasound appearances and subsequent neurodevelopmental and neurological deficits. The highest incidence of this condition was found in infants at and below 27 weeks gestation, and occurred in 15% of very premature infants surviving 14 days or more. Cavities developed 15 days after the onset of periventricular echodensity (median time). Ventricular dilatation occurred in 24% of the infants who developed cavities. Follow up information was available in 27 infants and 18 of these (67%) had significant neurodevelopmental handicap. The location of echolucent cavities were described as involving anterior, middle or posterior cerebral zones or any combination of these. Cerebral palsy was closely related to the presence of cavities, but there was little association between cavities and developmental delay. Four factors were found to predict cerebral palsy: cavities within the occipital zone, the involvement of multiple regions of the brain, lesions greater than 1 cm in diameter and cavities associated with subcortical leukomalacia. Lesions confined to the anterior or middle zones were unlikely to be associated with significant handicap. The presence of cavities per se was not associated with a higher incidence of severe developmental delay.
authors.affiliation: Department of Child Health, Leicester University School of Medicine, Great Britain.
authors.forename: D
authors.initials: D
authors.lastname: Shortland
authors.forename: M I
authors.initials: MI
authors.lastname: Levene
authors.forename: J
authors.initials: J
authors.lastname: Trounce
authors.forename: Y
authors.initials: Y
authors.lastname: Ng
authors.forename: M
authors.initials: M
authors.lastname: Graham
mesh_terms: D002547:Cerebral Palsy / Q000209:etiology; D015331:Cohort Studies; D004678:Encephalomalacia / Q000503:physiopathology*; D004739:England; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007969:Leukomalacia, Periventricular / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D011379:Prognosis; D013997:Time Factors