Astrocyte mitogen inhibitor related to epidermal growth factor receptor.
Epidermal growth factor (EGF) is a well-characterized polypeptide hormone with diverse biological activities, including stimulation of astrocyte division. A soluble astrocyte mitogen inhibitor, immunologically related to the EGF receptor, is present in rat brain. Injury to the brain causes a time-dependent reduction in the levels of this inhibitor and the concomitant appearance of EGF receptor on the astrocyte surface. Intracerebral injection of antibody capable of binding the inhibitor caused the appearance of numerous reactive astrocytes. EGF receptor-related inhibitors may play a key role in the control of glial cell division in both normal and injured brain.
Nieto-Sampedro
M
M
Department of Psychobiology, University of California, Irvine 92717.
D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D001930:Brain Injuries / Q000503:physiopathology*; D002455:Cell Division; D003429:Cross Reactions; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000276:immunology; D007158:Immunologic Techniques; D051381:Rats; D011975:Receptors, Mitogen / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013997:Time Factors
D011975:Receptors, Mitogen; D066246:ErbB Receptors