Promoting effects of 105K glycoprotein on cell proliferation in chicken lymphoblastoid cell lines.
The promoting effects on cell proliferation of the 105K glycoprotein (105Kgp), purified from sera of chickens to which a Marek's disease (MD) lymphoblastoid cell line, MDCC-MSB1-41C (MSB1-41C), had been transplanted, were examined using culture cells from various sources. The MSB1-41C line as well as the other chicken lymphoblastoid cell lines examined were sensitive to the 105Kgp. The growth-promoting effects of 105Kgp showed a biphasic pattern depending upon the amount of 105Kgp added into the culture medium. These findings indicate that the 105Kgp may be a promoting factor for chicken growing cells, especially lymphoblastoid cell lines.
Kotomura
N
N
Department of Microbiology and Hygiene, Faculty of Applied Biological Science, Hiroshima University, Japan.
Matsuda
H
H
Murata
M
M
Matsumura
K
K
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002645:Chickens; D006023:Glycoproteins / Q000097:blood / Q000494:pharmacology*; D006133:Growth Substances / Q000097:blood / Q000494:pharmacology; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D008380:Marek Disease / Q000097:blood; D008970:Molecular Weight
D006023:Glycoproteins; D006133:Growth Substances