title: Standard method for the investigation of bone transplants, ceramics, or other material in a human bony layer.
abstract: A new model for the investigation of human bone regeneration is introduced. We use the iliac crest as a bony layer for implants, which are the object of research. For therapy in cases of delayed bone healing the cancellous bone is removed. The empty iliac crest is then filled with the material we want to investigate. During a further operation necessitated by therapy of the bone disease, we obtain a probe of bone and material by drilling a hole through the iliac crest. This bony cylinder can be examined by histological techniques. We have used this procedure in 69 patients to date. No specific complications were caused by the implants. Fifteen biopsies could be taken and are now under examination. In the future it may be possible to breed new bone in this layer for further therapy and to fill the gaps at donor sites.
authors.affiliation: Berufsgenossenschaftliche Unfallklinik Duisburg-Buchholz, Federal Republic of Germany.
authors.forename: M
authors.initials: M
authors.lastname: Roesgen
authors.forename: G
authors.initials: G
authors.lastname: Hierholzer
mesh_terms: D001847:Bone Diseases / Q000601:surgery; D001861:Bone Regeneration; D016025:Bone Transplantation; D002516:Ceramics; D006801:Humans; D007085:Ilium / Q000601:surgery; D019736:Prostheses and Implants