p53 increases experimental metastatic capacity of murine carcinoma cells.
Transfection of a cloned p53 gene into a murine bladder carcinoma cell with a low metastatic capacity led to elevated levels of p53 protein in clonal transfectants. After intravenous inoculation into syngeneic mice, p53-transfected clones showed significantly increased metastatic potential in comparison with control transfectants. The observed change did not seem to be due to a change in growth potential per se since the cell lines showed similar growth properties in vitro.
Pohl
J
J
Institute for Immunology and Genetics, German Cancer Research Center, Heidelberg.
Goldfinger
N
N
Radler-Pohl
A
A
Rotter
V
V
Schirrmacher
V
V
D000818:Animals; D002277:Carcinoma / Q000473:pathology* / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology*; D009368:Neoplasm Transplantation; D010750:Phosphoproteins / Q000235:genetics / Q000502:physiology*; D011994:Recombinant Proteins / Q000502:physiology; D014162:Transfection; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53; D001749:Urinary Bladder Neoplasms / Q000473:pathology
D009363:Neoplasm Proteins; D010750:Phosphoproteins; D011994:Recombinant Proteins; D016159:Tumor Suppressor Protein p53