[Effectiveness and safety of using cyclosporin A in the treatment of primary Sjögren's syndrome].
We used oral cyclosporine-A (CyA) (5 mg/kg/day) initially in a double blind study for 6 mos. 10 patients received CyA and 10 placebo. At the end of this study it was observed that CyA improved subjective xerostomia, while subjective xerophthalmia, parotid gland enlargement, Schirmer-I-test and parotid flow rate did not show any significant differences in the two study groups. 9 of 10 patients who had received CyA for 6 mos and 9 of 10 in the placebo group continued in an open trial (CyA at the same dose) for an additional 6 mos. At the end of the study the only efficacy of CyA observed was improvement of subjective xerostomia. The side-effects observed were hypertrichosis (14 persons), mild hypertension (4), infections (5) and 3 dropped out because of nausea, tremor, paresthesias and infections. In conclusion, small doses of CyA for 12 mos are rather ineffective for Sjogren's syndrome.
Drosos
A A
AA
Moutsopoulos
N M
NM
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003524:Cyclosporins / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012469:Salivary Glands / Q000187:drug effects / Q000378:metabolism; D012472:Salivation / Q000187:drug effects; D012859:Sjogren's Syndrome / Q000188:drug therapy*; D014985:Xerophthalmia / Q000188:drug therapy; D014987:Xerostomia / Q000188:drug therapy
D003524:Cyclosporins
Effektivnost' i bezopasnost' primeneniia tsiklosporina A pri lechenii pervichnogo sindroma Shegrena.