Structural analogies between adhesive proteins and cysteine proteinase inhibitors.
Structural analogies were found between adhesive proteins, fibronectin and laminin, and a group of cysteine proteinase inhibitors. The sequences analogous with inhibitors occur in both adhesive molecules in the vicinity of their cell-binding sites: they comprise residues 1112-1212 in fibronectin and residues 1538-1639 of B1 chain in laminin. Both adhesive molecules display the highest degree of analogy with stefin-type inhibitors. The structural analogies also exist between fibronectin, laminin and P21, the c-Ha-ras gene protein produced by Escherichia coli.
Keil-Dlouha
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Unité de Chimie des Protéines, Institut Pasteur, Paris, France.
Turk
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D000595:Amino Acid Sequence; D000818:Animals; D015853:Cysteine Proteinase Inhibitors; D005353:Fibronectins / Q000032:analysis*; D006801:Humans; D007797:Laminin / Q000032:analysis*; D051379:Mice; D008969:Molecular Sequence Data; D008970:Molecular Weight; D011480:Protease Inhibitors / Q000032:analysis*
D015853:Cysteine Proteinase Inhibitors; D005353:Fibronectins; D007797:Laminin; D011480:Protease Inhibitors