HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA phenotype B27,B44.
In a consecutive case study 231 patients with Crohn's disease were investigated for ankylosing spondylitis (AS) and HLA-A, B, C, DR antigen association. Eighteen patients (7.8%) had definite AS according to the New York criteria; 13 (72%) were HLA-B27 positive. The phenotype B27,B44 was seen in 8 patients (44%) compared to only 3 (1%) of 300 controls (p less than 10(-7), and 1 (0.5%) of 213 patients with Crohn's disease without AS (p less than 10(-7). We conclude that patients with the phenotype B27,B44 are highly at risk (relative risk = 68.8) for the common manifestation of Crohn's disease and AS.
Purrmann
J
J
Department of Gastroenterology, University of Düsseldorf, FRG.
Zeidler
H
H
Bertrams
J
J
Juli
E
E
Cleveland
S
S
Berges
W
W
Gemsa
R
R
Specker
C
C
Reis
H E
HE
D000328:Adult; D003424:Crohn Disease / Q000150:complications* / Q000276:immunology; D004198:Disease Susceptibility; D005260:Female; D015235:HLA-B Antigens / Q000032:analysis*; D015796:HLA-B27 Antigen; D059948:HLA-B44 Antigen; D015236:HLA-C Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012307:Risk Factors; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000276:immunology
D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D059948:HLA-B44 Antigen; D015236:HLA-C Antigens; C048767:HLA-C*02 antigen