Drug interactions in hypertension.
Interactions between drugs and antihypertensive agents can result in either increased or decreased antihypertensive effects. These interactions may be pharmacokinetic or pharmacodynamic in type, resulting in either altered plasma drug concentrations or altered drug effects at similar plasma concentrations. Drugs may limit the absorption of antihypertensive agents, alter their metabolism through either enzyme inhibition or induction, or change renal excretion. In addition, by altering cardiovascular and volume homeostasis, changes in antihypertensive response may be produced.
Wood
A J
AJ
Department of Medicine, Vanderbilt University, School of Medicine, Nashville, TN 37232.
D000959:Antihypertensive Agents / Q000494:pharmacology; D004347:Drug Interactions; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008019:Life Style; D010599:Pharmacokinetics
D000959:Antihypertensive Agents