title: Monoamine oxidase inhibitors and anaesthesia. A review.
abstract: There has been a recent renewal of interest in the use of monoamine oxidase inhibitors in psychiatry. The concurrent administration of anaesthetic agents, particularly narcotic analgesics, is often a cause for concern. Although many monoamine oxidase inhibitor-drug interactions have been reported, in practice it is only the interaction with pethidine which has led to fatalities. What is not appreciated is that the monoamine oxidase inhibitor-pethidine interaction has two distinct forms-"excitatory" and "depressive". It is this lack of appreciation that has led to much confusion when dealing with patients taking monoamine oxidase inhibitors.
authors.affiliation: Shackleton Department of Anaesthetics, Southampton General Hospital.
authors.forename: C G
authors.initials: CG
authors.lastname: Stack
authors.forename: P
authors.initials: P
authors.lastname: Rogers
authors.forename: S P
authors.initials: SP
authors.lastname: Linter
mesh_terms: D000758:Anesthesia; D000777:Anesthetics / Q000009:adverse effects; D004347:Drug Interactions; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects*
chemical_list: D000777:Anesthetics; D008996:Monoamine Oxidase Inhibitors