title: Adrenergic innervation of aortic patch-grafts in rats.
abstract: The regeneration of vascular adrenergic nerves was studied using the glyoxylic acid-induced fluorescence method for the specific demonstration of adrenergic nerves in syngeneic patch-grafts of the right atrium of the heart, vena cava and glutaraldehyde-treated vena cava transplanted into the abdominal aorta of the rat. Glutaraldehyde-treated segments of the supradiaphragmatic inferior vena cava were transplanted into the abdominal aorta of rats as well. At the end of the observation period of 24 weeks limited, patchy and defective innervation was observed in the syngeneic vena cava and atrial patches. No adrenergic nerves were found in the glutaraldehyde-treated vein patch-grafts or vein grafts. Owing to the very poor innervation of atrial and venous patch-grafts the results are not entirely in agreement with the target organ concept of adrenergic nerve regeneration. In this study the suture line around the patch graft probably hampers regeneration of vascular adrenergic nerves in the patches.
authors.affiliation: Department of Surgery, Oulu University Central Hospital, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Waris
authors.forename: J
authors.initials: J
authors.lastname: Hukki
authors.forename: T
authors.initials: T
authors.lastname: Lähteenmäki
authors.forename: T
authors.initials: T
authors.lastname: Löfstedt
authors.forename: K
authors.initials: K
authors.lastname: Kyösola
authors.forename: K
authors.initials: K
authors.lastname: van Smitten
mesh_terms: D000320:Adrenergic Fibers / Q000502:physiology*; D000714:Anastomosis, Surgical; D000818:Animals; D001012:Aorta, Abdominal / Q000294:innervation / Q000601:surgery*; D002395:Catecholamines / Q000032:analysis; D006325:Heart Atria / Q000601:surgery; D008856:Microscopy, Fluorescence; D009416:Nerve Regeneration; D051381:Rats; D011917:Rats, Inbred Lew; D014682:Vena Cava, Inferior / Q000637:transplantation
chemical_list: D002395:Catecholamines