title: Combined therapy with cisapride and cimetidine in severe reflux oesophagitis: a double blind controlled trial.
abstract: Combined treatment with cimetidine 1 g daily and cisapride 40 mg daily in patients with endoscopically diagnosed severe reflux oesophagitis was compared with single drug therapy (cimetidine and placebo). At the end of the six to 12 weeks treatment, 11 (46%) of the 24 patients under single drug therapy were endoscopically healed and three were improved. In contrast, 16 (70%) of the 23 patients under combined therapy were healed and all of the remainder were improved (p = 0.025). The severity of diurnal and nocturnal heartburn, decreased significantly more (p less than 0.05) on cimetidine + cisapride than on cimetidine + placebo. The combined treatment was well tolerated. These results suggest that combined therapy with cisapride and cimetidine may be useful in patients with severe reflux oesophagitis.
authors.affiliation: Clinique des maladies de l'appareil digestif, Hôpital Guillaume et René Laennec, Nantes, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Galmiche
authors.forename: G
authors.initials: G
authors.lastname: Brandstätter
authors.forename: M
authors.initials: M
authors.lastname: Evreux
authors.forename: E
authors.initials: E
authors.lastname: Hentschel
authors.forename: E
authors.initials: E
authors.lastname: Kerstan
authors.forename: P
authors.initials: P
authors.lastname: Kratochvil
authors.forename: W
authors.initials: W
authors.lastname: Reichel
authors.forename: K
authors.initials: K
authors.lastname: Schütze
authors.forename: J C
authors.initials: JC
authors.lastname: Soule
authors.forename: J
authors.initials: J
authors.lastname: Vitaux
mesh_terms: D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000627:therapeutic use*; D020117:Cisapride; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations; D004942:Esophagitis, Peptic / Q000188:drug therapy*; D004945:Esophagoscopy; D005260:Female; D006356:Heartburn / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D011897:Random Allocation
chemical_list: D004338:Drug Combinations; D010880:Piperidines; D002927:Cimetidine; D020117:Cisapride