A role for prostaglandins in estrogen growth regulation.
Several lines of evidence support the theory that estrogen increases prostaglandin F2 alpha (PGF2 alpha) receptor number and amplifies the intracellular response to the uterine mitogen, PGF2 alpha, in primary cultures of rabbit endometrium. It is proposed here that estrogen induction of growth in target tissues may be mediated through prostaglandins. Determination of prostaglandin receptor status and prostaglandin levels in estrogen dependent tumors could be of importance as diagnostic tools. The use of prostaglandin synthesis inhibitors and/or antagonists in the therapy of these tumors should be considered.
Orlicky
D J
DJ
Department of Pathology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262.
Lieberman
R
R
Gerschenson
L E
LE
D000818:Animals; D002455:Cell Division; D015237:Dinoprost; D004958:Estradiol / Q000378:metabolism*; D006801:Humans; D011460:Prostaglandins F / Q000378:metabolism*; D011817:Rabbits; D011982:Receptors, Prostaglandin / Q000378:metabolism
D011460:Prostaglandins F; D011982:Receptors, Prostaglandin; C034671:prostaglandin F2alpha receptor; D004958:Estradiol; D015237:Dinoprost