title: Statistical analysis of nucleotide runs in coding and noncoding DNA sequences.
abstract: A statistical analysis of the occurrence of particular nucleotide runs in DNA sequences of different species has been carried out. There are considerable differences of run distributions in DNA sequences of procaryotes, invertebrates and vertebrates. There is an abundance of short runs (1-2 nucleotides long) in the coding sequences and there is a deficiency of such runs in the noncoding regions. However, some interesting exceptions from this rule exist for the run distribution of adenine in procaryotes and for the arrangement of purine-pyrimidine runs in eucaryotes. The similarity in the distributions of such runs in the coding and noncoding regions may be due to some structural features of the DNA molecule as a whole. Runs of guanine (or cytosine) of three to six nucleotides occur predominantly in noncoding DNA regions in eucaryotes, especially in vertebrates.
authors.affiliation: Institute of Molecular Genetics USSR Academy of Sciences, Moscow.
authors.lastname: Sprizhitsky YuA
authors.lastname: Nechipurenko YuD
authors.forename: A A
authors.initials: AA
authors.lastname: Alexandrov
authors.forename: M V
authors.initials: MV
authors.lastname: Volkenstein
mesh_terms: D000818:Animals; D001482:Base Composition; D001483:Base Sequence; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004247:DNA / Q000235:genetics; D005091:Exons; D005658:Fungi / Q000235:genetics; D007438:Introns; D007448:Invertebrates / Q000235:genetics; D008322:Mammals / Q000235:genetics; D013223:Statistics as Topic; D014714:Vertebrates / Q000235:genetics
chemical_list: D004247:DNA