Dietary supplementation with pectin in the maintenance treatment of duodenal ulcer. A controlled study.
Patients with recently healed duodenal ulcers diagnosed by endoscopy were randomly allocated to receive 10 g apple pectin USP powder twice daily, 150 mg ranitidine at night, or one tablet matching ranitidine placebo at night for 6 months. Repeat endoscopy was performed at 6 months or if symptoms recurred. Eighty-three patients completed the study. Recurrences occurred in 23 of 27 (85%) patients taking pectin, 6 of 28 (21%) patients taking ranitidine, and 20 of 28 (71%) patients taking placebo. (Pectin versus placebo, NS; ranitidine versus pectin, p less than 0.00001; ranitidine versus placebo, p less than 0.0005). The average amount of pectin taken was 12.7 g/day in patients who relapsed and 12.4 g/day in those who did not. At the doses taken, therefore, dietary supplementation with pectin did not reduce the incidence of duodenal ulcer relapse.
Kang
J Y
JY
Dept. of Medicine, National University of Singapore, National University Hospital.
Tay
H H
HH
Guan
R
R
Math
M V
MV
Yap
I
I
Labrooy
S J
SJ
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000178:diet therapy* / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010368:Pectins / Q000008:administration & dosage* / Q000009:adverse effects; D011899:Ranitidine / Q000009:adverse effects / Q000627:therapeutic use; D012008:Recurrence
D011899:Ranitidine; D010368:Pectins