Genotoxicity in the hepatocyte/DNA repair test and toxicity to liver mitochondria of 1-hydroxyanthraquinone and several dihydroxyanthraquinones.
1-Hydroxyanthraquinone and dihydroxyanthraquinones (alizarin, quinizarin, anthrarufin and chrysazin) were examined for genotoxicity in the hepatocyte/DNA repair test and for effects on oxidative phosphorylation in isolated rat liver mitochondria. Of the anthraquinone compounds tested, 1-hydroxyanthraquinone and 1,8-dihydroxyanthraquinone (chrysazin) induced DNA repair synthesis in rat hepatocytes, indicating their genotoxic activity. Only 1,2-dihydroxyanthraquinone (alizarin) exerted an uncoupling and inhibitory effect on mitochondrial respiration. The possible relationships of the genotoxic potencies and the uncoupling activities of these anthraquinones to their chemical structures are discussed.
Kawai
K
K
Department of Food and Nutrition, Faculty of Home Economics, Chukyo Women's University, Aichi, Japan.
Mori
H
H
Sugie
S
S
Yoshimi
N
N
Inoue
T
T
Nakamaru
T
T
Nozawa
Y
Y
Matsushima
T
T
D000818:Animals; D000880:Anthraquinones / Q000633:toxicity*; D004260:DNA Repair / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects*; D009152:Mutagenicity Tests; D051381:Rats
D000880:Anthraquinones; C061208:1-hydroxyanthraquinone