[Characteristics of the mutagenic and toxic effects of ethylene imine and its oligomers. Comparative study in the automated SOS-chromotest system and in standard bacterial test systems].
Raising total positive charge of a chemical mutagen does increase its local concentration in the area of biological target-DNA, and, as a consequence, causes increase in the rate of interaction of a mutagen with the target. Experimental evidence of this idea has been obtained in three test systems: the Ames test, Trp+ reversions in Escherichia coli WP2 and in the automated "SOS-chromotest" system with E. coli PQ 37 ("Labsystems", Finland).
Tanirbergenov
T B
TB
Vasil'eva
S V
SV
Kostianovskiĭ
R G
RG
Rappoport
I A
IA
Huttunen
T
T
D001388:Aziridines / Q000633:toxicity*; D001389:Azirines / Q000633:toxicity*; D004260:DNA Repair; D004926:Escherichia coli / Q000235:genetics; D009152:Mutagenicity Tests; D009153:Mutagens; D013014:SOS Response, Genetics; D012486:Salmonella typhimurium / Q000235:genetics; D013329:Structure-Activity Relationship
D001388:Aziridines; D001389:Azirines; D009153:Mutagens; C033132:aziridine
Zakonomernosti mutagennogo i toksicheskogo deĭstviia étilenimina i ego oligomerov. Sravnitel'noe izuchenie v avtomatizirovannoĭ sisteme SOS-khromotest i v standartnykh bakterial'nykh test-sistemakh.