Plasma levels and therapeutic response with trimipramine treatment of endogenous depression.
In a 6-week, double-blind study involving 34 endogenously depressed patients, plasma trimipramine levels of two dosage groups, 75-mg/day and 150-mg/day, were compared with regard to clinical efficacy as determined by scores on the Hamilton Rating Scale for Depression, the Clinical Global Impressions scale, and the Zung Self-Rating Depression Scale. Both dosage levels of trimipramine produced prompt, consistent, and progressive antidepressant effects. No correlation between plasma levels and clinical efficacy was found.
Simpson
G M
GM
Department of Psychiatry, Medical College of Pennsylvania, Philadelphia 19129.
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E H
EH
Gross
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Baron
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November
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D000328:Adult; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D003984:Dibenzazepines / Q000097:blood*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011897:Random Allocation; D012894:Sleep Stages; D014299:Trimipramine / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D014987:Xerostomia / Q000139:chemically induced
D003984:Dibenzazepines; D014299:Trimipramine