The effect of oxygen toxicity and cigarette smoking on the binding of heterologous antibodies to alveolar basement membrane in the rat.
It has been suspected that pulmonary lesions of the Goodpasture type may be the result of circulating antibodies to alveolar basement membrane and that environmental factors such as cigarette smoke may influence antibody binding. Carefully designed experiments in this study have shown that exposure to cigarette smoke for 3 weeks or 100% oxygen for 65 h did not influence the binding of heterologous antibodies to alveolar basement membrane in Wistar rats, nor did these regimes increase any pathological changes associated with the antibody binding as detected by light microscopy. The results which are at variance with other reported findings are discussed with reference to reported animal models of antibody mediated pneumonitis and Goodpasture's syndrome in man.
Rhodes
G C
GC
School of Pathology, University of New South Wales, Sydney, Australia.
Horn
J
J
Watkins
S G
SG
Yong
L C
LC
D000818:Animals; D000910:Antibodies, Heterophile / Q000276:immunology*; D001485:Basement Membrane / Q000276:immunology*; D001666:Binding Sites, Antibody / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D005260:Female; D005455:Fluorescent Antibody Technique; D008297:Male; D010100:Oxygen / Q000633:toxicity*; D011650:Pulmonary Alveoli / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D012907:Smoking / Q000009:adverse effects*
D000910:Antibodies, Heterophile; D010100:Oxygen