[Possibilities and limitations of using inhaled sympathomimetics in patients with bronchial asthma in older age groups].
Using a method of circadian ECG monitoring, the authors detected a peculiar phenomenon of frequent arrhythmic action of sympathomimetic inhalants in patients with bronchial asthma, mainly during remission. Possible interpretation of the results obtained was as follows: reduction during remission of functional beta block including heart block determining "cardioprotective" action in sympathomimetic inhalations; depletion of reserves of myocardial sympathetic mediators at the height of exacerbation of bronchial asthma; peculiarities of absorption of sympathomimetic inhalants with relation to a stage of disease. The authors discussed the potentialities and limitations of the use of sympathomimetic inhalants during exacerbation and remission of bronchial asthma with relation to patients' age and concomitant coronary heart disease.
Gembitskiĭ
E V
EV
Sinopal'nikov
A I
AI
Alekseev
V G
VG
D000280:Administration, Inhalation; D000367:Age Factors; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D006801:Humans; D008297:Male; D008875:Middle Aged; D013566:Sympathomimetics / Q000008:administration & dosage* / Q000009:adverse effects
D001993:Bronchodilator Agents; D013566:Sympathomimetics
Vozmozhnosti i ogranicheniia primeneniia ingaliatsionnykh simpatomimetikov u bol'nykh bronkhial'noĭ astmoĭ v starshikh vozrastnykh gruppakh.