Antinuclear autoantibodies specific for lamins. Characterization and clinical significance.
In 11 patients, sera displaying a ringlike nuclear immunofluorescent staining on sections of rat liver tissue were shown by Western blotting to contain antibodies to lamins. Sera from 8 patients contained autoantibodies reacting with lamin B, whereas sera from the other 3 patients reacted with lamins A and C. All patients (9 women and 2 men) had a chronic autoimmune disorder, which rarely fulfilled the usual criteria for a diagnosis of systemic lupus erythematosus. The disorder was characterized by acute or chronic (active or granulomatous) hepatitis; steroid-responsive blood cytopenia, often associated with a circulating anticoagulant, or anticardiolipin antibodies, or both; and cutaneous leukocytoclastic angiitis or probable brain vasculitis. Eight patients had at least two of these three conditions. Antilamin autoantibodies may thus be a marker for an unusual subset of autoimmune diseases.
Lassoued
K
K
Laboratory of Immunochemistry and Immunopathology, INSERM U 108, University of Paris VII, France.
Guilly
M N
MN
Danon
F
F
Andre
C
C
Dhumeaux
D
D
Clauvel
J P
JP
Brouet
J C
JC
Seligmann
M
M
Courvalin
J C
JC
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis / Q000276:immunology*; D000918:Antibody Specificity; D001327:Autoimmune Diseases / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006402:Hematologic Diseases / Q000276:immunology; D006801:Humans; D007158:Immunologic Techniques; D034921:Lamin Type B; D034882:Lamins; D008107:Liver Diseases / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000276:immunology*; D014657:Vasculitis / Q000276:immunology
D000974:Antibodies, Antinuclear; D034921:Lamin Type B; D034882:Lamins; D009687:Nuclear Proteins