title: Recognition and treatment of endotoxemia.
abstract: Endotoxemia occurs secondary to several diseases that disrupt the mucosal barrier to bacteria or their toxins. The effects of endotoxemia are varied and are mediated by a wide variety of proinflammatory substances. Although evidence certainly exists to incriminate the cyclooxygenase-derived products of arachidonic acid in the early responses to endotoxemia, various other mediators must also be considered. Treatment presently involves fluid replacement, correction of acid-base abnormalities, augmentation of cardiovascular function, and inhibition of cyclooxygenase activity.
authors.affiliation: Department of Large Animal Medicine, University of Georgia College of Veterinary Medicine, Athens.
authors.forename: J N
authors.initials: JN
authors.lastname: Moore
mesh_terms: D000818:Animals; D004731:Endotoxins / Q000032:analysis*; D006734:Horse Diseases / Q000175:diagnosis / Q000628:therapy; D006736:Horses; D012772:Shock, Septic / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*
chemical_list: D004731:Endotoxins