Testing a mechanism of control in human cholesterol metabolism: relation of arginine and glycine to insulin and glucagon.
Eight men were given 2 casein meals, one with and one without a supplement of arginine and glycine, to measure the effect on plasma amino acids, insulin and glucagon. Supplementation resulted in increased levels of plasma glucagon, glycine and arginine, a tendency to decreased insulin and significantly lower insulin/glucagon ratio, tryptophan and tyrosine. The data suggest that insulin and glucagon, which control cholesterol metabolism, respond to dietary and postprandial plasma amino acid levels of arginine and glycine.
Sanchez
A
A
School of Public Health; Department of Pathology, Loma Linda University, CA 92350.
Hubbard
R W
RW
Smit
E
E
Hilton
G F
GF
D000596:Amino Acids / Q000097:blood; D001120:Arginine / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism*; D004044:Dietary Proteins / Q000494:pharmacology*; D005934:Glucagon / Q000097:blood* / Q000502:physiology; D005998:Glycine / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000502:physiology; D008297:Male; D008875:Middle Aged
D000596:Amino Acids; D004044:Dietary Proteins; D007328:Insulin; D005934:Glucagon; D001120:Arginine; D002784:Cholesterol; D005998:Glycine