Relapse of systemic lupus erythematosus in a patient receiving cyclosporine A.
Cyclosporine A (CyA) is being increasingly used as an immunosuppressive agent to treat various autoimmune diseases. A patient with systemic lupus erythematosus (SLE) receiving CyA after renal transplantation suffered a disease relapse associated with high serum CyA levels. Lowering of the CyA dose and the start of steroids resulted in a rapid improvement in her condition. Trials evaluating CyA for SLE should proceed with caution since under certain circumstances this drug may exacerbate disease activity.
Makover
D
D
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.
Freundlich
B
B
Zurier
R B
RB
D000328:Adult; D003524:Cyclosporins / Q000009:adverse effects* / Q000097:blood; D005260:Female; D005921:Glomerulonephritis / Q000628:therapy; D006801:Humans; D016030:Kidney Transplantation; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced*; D011605:Psychoses, Substance-Induced / Q000209:etiology; D012008:Recurrence; D012640:Seizures / Q000139:chemically induced
D003524:Cyclosporins