Effect of insulin deficiency on low density lipoprotein metabolism in rabbits.
These studies have been carried out in rabbits with alloxan-induced diabetes in order to see if insulin deficiency affects low density lipoprotein (LDL) catabolism. The results showed that plasma LDL-cholesterol was lower in diabetic rabbits, associated with a fall in the cholesterol to protein ratio of LDL particles. In addition, 125I-LDL disappeared more slowly from plasma of diabetic rabbits, leading to a significant reduction in fractional catabolic rate and a decrease in residence time of 125I-LDL. These data demonstrated that LDL composition and catabolism are greatly altered as a consequence of insulin deficiency.
Golay
A
A
Department of Medicine, Stanford University School of Medicine.
Zech
L
L
Shi
M Z
MZ
Chiou
Y A
YA
Reaven
G M
GM
Chen
Y D
YD
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D007328:Insulin / Q000097:blood / Q000172:deficiency*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol