CD1c antigens are present in normal and neoplastic B-cells.
The immunohistochemical detection of CD1c antigen is described in mantle zone B-cells of the tonsil, lymph node, and spleen, and also in the marginal zone B-cells of the spleen. CD1c expression was observed in most cases of low-grade, but in only a single case of high-grade, B-cell non-Hodgkin's lymphoma. It was not detected in germinal centre cells, nor in Epstein-Barr virus-transformed or Burkitt's lymphoma B-cell lines. This distribution suggests that CD1c expression may occur preferentially in slowly proliferating B-cell populations and does not support previous suggestions that CD1c is a human equivalent of the mouse thymus leukaemia antigens.
Smith
M E
ME
Histopathology Unit, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, U.K.
Thomas
J A
JA
Bodmer
W F
WF
D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis*; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D009000:Monocytes / Q000276:immunology; D014066:Palatine Tonsil / Q000276:immunology; D013154:Spleen / Q000276:immunology
D000944:Antigens, Differentiation, B-Lymphocyte