Long-term survivors of kidney transplantation, mortality, rehabilitation, and immunologic reactivities.
1. The overall patient and graft survival rates (83.6% and 82% respectively) up to 23 years posttransplant of the group who survived a minimum of 10 years is reasonably good regardless of the donor source. 2. The primary grafts that survived a minimum of 10 years and were lost during the subsequent 12 years (17.7%) were equally due to rejection and the death of the patient. 3. Rehabilitation of the long-term survivor has been very good. Cardiovascular disease is becoming a significant morbidity among pediatric-aged recipients reaching the thirties. 4. The causes of death after 10-year survival are evenly distributed among infection, cardiovascular disease, neoplasms, dialysis, and hepatic failure. 5. The selected studies of immunologic reactivities in the long-term survivors show their failure to generate significant killing against donor-specific antigens while displaying normal MLR response against donor and third party. Significant depressions in their ability to respond in vitro to soluble antigens was also demonstrated.
Lee
H M
HM
Department of Surgery and Microbiology/Immunology, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298.
Kenyon
N
N
Mendez-Picon
G
G
Posner
M P
MP
D002102:Cadaver; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D007159:Immunologic Tests; D016030:Kidney Transplantation / Q000401:mortality / Q000502:physiology* / Q000534:rehabilitation; D014019:Tissue Donors