title: Antibacterial activities of fluorovinyl- and chlorovinylglycine and several derived dipeptides.
abstract: The in vitro antibacterial activities of several halovinylglycine compounds and their L-norvalyl peptide derivatives are presented. The most potent of them, L-norvalyl-L-chlorovinylglycine, displayed good activity against gram-positive organisms, including methicillin-resistant Staphylococcus species. Chlorovinylglycine is an efficient inhibitor of alanine racemase, but the antibacterial activity of L-norvalyl-L-chlorovinylglycine may involve other physiological targets as well.
authors.affiliation: Merck, Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065.
authors.forename: A A
authors.initials: AA
authors.lastname: Patchett
authors.forename: D
authors.initials: D
authors.lastname: Taub
authors.forename: B
authors.initials: B
authors.lastname: Weissberger
authors.forename: M E
authors.initials: ME
authors.lastname: Valiant
authors.forename: H
authors.initials: H
authors.lastname: Gadebusch
authors.forename: N A
authors.initials: NA
authors.lastname: Thornberry
authors.forename: H G
authors.initials: HG
authors.lastname: Bull
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003470:Culture Media; D003523:Cycloserine / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007700:Kinetics; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D004151:Dipeptides; C055749:fluorovinylglycine; C055748:chlorovinylglycine; D003523:Cycloserine; D005998:Glycine