title: Maintenance of high-energy brain phosphorous compounds during insulin-induced hypoglycemia in men. 31P nuclear magnetic resonance spectroscopy study.
abstract: 31P nuclear magnetic resonance (NMR) spectroscopy allows noninvasive studies of cerebral energy-rich phosphorous compounds in humans. In an attempt to characterize the relationship between peripheral blood glucose concentrations and whole-brain phosphate metabolism during insulin-induced hypoglycemia, 31P NMR spectra were obtained before and after intravenous injection of insulin (0.15 IU/kg body wt) in six men. Compared with prehypoglycemic measurements, no significant changes were found in brain content of Pi, sugar phosphates, phosphocreatine, phosphodiesters, and ATP, and brain pH remained constant during the experiment. These results show that the integrated brain profile of energy-rich phosphorous compounds is unaffected by experimental insulin-induced hypoglycemia in humans.
authors.affiliation: Department of Magnetic Resonance, Hvidovre Hospital, Copenhagen, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Hilsted
authors.forename: K E
authors.initials: KE
authors.lastname: Jensen
authors.forename: C
authors.initials: C
authors.lastname: Thomsen
authors.forename: S
authors.initials: S
authors.lastname: Larsen
authors.forename: O
authors.initials: O
authors.lastname: Henriksen
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D001921:Brain / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007003:Hypoglycemia / Q000139:chemically induced / Q000378:metabolism*; D007328:Insulin; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010755:Organophosphates / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D013403:Sugar Phosphates / Q000378:metabolism
chemical_list: D007328:Insulin; D010755:Organophosphates; D010710:Phosphates; D013403:Sugar Phosphates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate