Factor B subtypes in Japanese patients with IgA nephropathy and with idiopathic membranous nephropathy.
The present paper describes a method of subtyping of properdin factor B (BF) using polyacrylamide gel isoelectric focusing followed by immunoblotting, and the distribution of BF subtypes in Japanese patients with IgA nephropathy or idiopathic membranous nephropathy (IMN) along with controls. BF*F allele was splitted into two suballeles, named BF*FA and BF*FB. There were significant differences in the BF suballele frequencies between the IMN patient group and the control group. A significant association of IMN with the BF FA subtype (p less than 0.05) and with the BF FB subtype (p less than 0.001) was also found. BF*FB may be a susceptibility suballele to IMN rather than BF*FA.
Nishimukai
H
H
Department of Forensic Medicine, Medical College of Oita, Japan.
Nakanishi
I
I
Kitamura
H
H
Tamaki
Y
Y
D000328:Adult; D011415:Complement Factor B / Q000235:genetics*; D004792:Enzyme Precursors / Q000235:genetics*; D005922:Glomerulonephritis, IGA / Q000276:immunology*; D015433:Glomerulonephritis, Membranous / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D007525:Isoelectric Focusing; D007564:Japan; D011110:Polymorphism, Genetic
D004792:Enzyme Precursors; D011415:Complement Factor B