Preliminary molecular studies on two chromosome 2 encoded genes, c-abl and beta 2M, in radiation-induced murine myeloid leukaemias.
The majority of radiation-induced murine myeloid leukaemias are characterized by deletion and/or translocation of an interstitial region of chromosome 2, and there is evidence that such events may occur very early in myeloid leukaemogenesis. Analyses presented and discussed here on the structure and function of two possibly relevant chromosome 2 encoded genes (c-abl and beta 2M) lead to the preliminary conclusion that neither are directly involved nor activationally changed by the characteristic chromosome 2 rearrangements.
Silver
A R
AR
Division of Radiation Oncogenesis, MRC Radiobiology Unit, Oxon, U.K.
Masson
W K
WK
Breckon
G
G
Cox
R
R
D000818:Animals; D002872:Chromosome Deletion; D004249:DNA Damage; D004273:DNA, Neoplasm / Q000032:analysis; D005796:Genes / Q000528:radiation effects*; D007951:Leukemia, Myeloid / Q000209:etiology / Q000235:genetics*; D007953:Leukemia, Radiation-Induced / Q000235:genetics*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016315:Proto-Oncogene Proteins c-abl; D011519:Proto-Oncogenes / Q000528:radiation effects*; D014178:Translocation, Genetic; D001613:beta 2-Microglobulin / Q000235:genetics*
D004273:DNA, Neoplasm; D011518:Proto-Oncogene Proteins; D001613:beta 2-Microglobulin; D016315:Proto-Oncogene Proteins c-abl