Postnatal effects of prenatal insult.
Exogenous agents may perturb development during the embryonic period and adversely affect the formation of organs. However, adverse effects on development are not limited to the embryonic period nor are the manifestations restricted solely to outright gross structural malformation, but may instead be expressed as a decrement or abberration of postnatal function. Susceptibility to altered development may extend well into the postnatal period. Studies of functional parameters in several organ systems have demonstrated the broad-based susceptibility, subtlety of expression and potential of long-lasting effects of altered development assessed by physiologic assays. Adverse effects on functional development, whether in the CNS, reproductive, gastrointestinal, genitourinary, respiratory, or immune systems, etc., merit continuing investigation. From the viewpoint of risk estimation and hazard detection, evaluations of postnatal functional parameters may be relevant for several reasons. First, such parameters may serve as low-dose triggers. Second, they may be useful as a focal point for epidemiological studies. Finally, a more thorough understanding of the degree and magnitude of such postnatal functional deficits is needed since an adverse maternal effect may be transient, considered acceptable, or unperceived, but the effect on the conceptus may be permanent and severe. The immune and respiratory systems are discussed as two examples of how subtle and protean adverse effects on functional development may be.
Johnson
E M
EM
Department of Anatomy, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Newman
L M
LM
Schmidt
R R
RR
D000818:Animals; D005260:Female; D006801:Humans; D007121:Immunocompetence / Q000187:drug effects*; D008168:Lung / Q000187:drug effects* / Q000196:embryology / Q000254:growth & development; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014801:Vitamin A / Q000633:toxicity
D014801:Vitamin A