Peculiarities of the effect of hormones and transmitters during aging: modulation of changes in dopaminergic action.
Loss of motor control is an important functional manifestation of aging. This dysfunction appears to be at least partially due to loss of striatal dopamine receptors. We have examined the possible mechanisms by which such a deterioration occurs as well as possible manipulations to delay and/or reverse these impairments.
Roth
G S
GS
Molecular Physiology and Genetics Section, National Institute on Aging, Francis Scott Key Medical Center, Baltimore, Md.
Joseph
J A
JA
D000375:Aging / Q000378:metabolism*; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism; D004032:Diet; D006801:Humans; D009069:Movement Disorders / Q000378:metabolism; D011388:Prolactin / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*
D011954:Receptors, Dopamine; D011388:Prolactin