title: Abnormal GM-CSA generation by lymphocytes in patients with cyclic hematopoiesis.
abstract: Human cyclic hematopoiesis (CH) is a disease characterized by regular 21-day cyclic fluctuations of blood cell counts due to fluctuations in bone marrow cell production. The regular periodicity of the fluctuations suggests a defect in a regulatory feedback control loop. We examined the production of monocyte-derived recruiting activity (MRA) by monocytes and the response to MRA of lymphocytes from three patients with CH. MRA production was normal or increased in patients' monocytes, but granulocyte-macrophage colony-stimulating activity (GM-CSA) production in response to MRA was decreased in lymphocytes from patients with CH (p = 0.005). These data suggest that the regulatory defect in CH may involve defective lymphocyte generation of GM-CSA, resulting in deficient production of mature neutrophils.
authors.affiliation: Department of Medicine, University of Washington, Seattle 98195.
authors.forename: W P
authors.initials: WP
authors.lastname: Hammond
authors.forename: J E
authors.initials: JE
authors.lastname: Miller
authors.forename: E
authors.initials: E
authors.lastname: McCall
mesh_terms: D003115:Colony-Stimulating Factors / Q000096:biosynthesis*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000096:biosynthesis*; D006410:Hematopoiesis; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism; D010507:Periodicity
chemical_list: D003115:Colony-Stimulating Factors; D006133:Growth Substances; D016178:Granulocyte-Macrophage Colony-Stimulating Factor