title: Can potential hazard of Creutzfeldt-Jakob disease infectivity be reduced in the production of human growth hormone? Inactivation experiments with the 263K strain of scrapie. Rapid communication.
abstract: Scrapie infectivity is reduced 5-6 logs following filtration through 100,000 MW cut-off filter plus overnight treatment with 6 M urea. These steps, applied to purified human Growth Hormone (hGH), increase the margin of safety of hGH.
authors.affiliation: Istituto di Neurologia, Universitá Cattolica S. Cuore, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pocchiari
authors.forename: G
authors.initials: G
authors.lastname: Macchi
authors.forename: S
authors.initials: S
authors.lastname: Peano
authors.forename: A
authors.initials: A
authors.lastname: Conz
mesh_terms: D000818:Animals; D007562:Creutzfeldt-Jakob Syndrome / Q000517:prevention & control*; D006224:Cricetinae; D005260:Female; D005374:Filtration; D013006:Growth Hormone / Q000302:isolation & purification*; D012608:Scrapie / Q000517:prevention & control*; D012972:Sodium Hydroxide; D014508:Urea
chemical_list: D012972:Sodium Hydroxide; D014508:Urea; D013006:Growth Hormone