title: Prolonged sedation with propofol in ICU patients: recovery and blood concentration changes during periodic interruptions in infusion.
abstract: Propofol (mean dose 2.85 mg kg-1 h-1) was administered for 4 days by continuous i.v. infusion for sedation in 14 agitated and restless ICU patients. This provided rapid control of the level of sedation. When the infusion was discontinued, adequate recovery with response to commands was obtained in most patients by 10 min. Recovery times and the decrease in blood propofol concentration were similar after 24, 48, 72 and 96 h of infusion. Cumulative effects, tachyphylaxis, or other untoward effects were not observed.
authors.affiliation: Service d'anesthésie-réanimation chirurgicale, Hôpital de Hautepierre, Strasbourg, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Beller
authors.forename: T
authors.initials: T
authors.lastname: Pottecher
authors.forename: A
authors.initials: A
authors.lastname: Lugnier
authors.forename: P
authors.initials: P
authors.lastname: Mangin
authors.forename: J C
authors.initials: JC
authors.lastname: Otteni
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003422:Critical Care; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D015742:Propofol; D013997:Time Factors
chemical_list: D006993:Hypnotics and Sedatives; D010636:Phenols; D015742:Propofol