title: Smoking, oncogenes and human lung cancer. A review of recent laboratory evidence linking smoking and lung cancer.
abstract: Recent molecular genetic experiments conducted in the USA and The Netherlands have isolated specific mutations in human lung cancer cells. These data implicate the activation of the K-ras oncogene in the pathogenesis of adenocarcinoma of the lungs of heavy smokers and the deletion of DNA from the short arm of chromosome 3 in small-cell and non-small-cell carcinoma of the lung. The implications of these results are discussed and explained in the light of current DNA-manipulative technology which is now available in RSA.
authors.affiliation: Department of Pharmacology, University of Stellenbosch, Parowvallei.
authors.forename: C F
authors.initials: CF
authors.lastname: Albrecht
authors.forename: E L
authors.initials: EL
authors.lastname: Theron
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D005347:Fibroblasts; D011905:Genes, ras; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D051379:Mice; D012907:Smoking