title: Coagulation abnormalities associated with neoplasia.
abstract: Subclinical abnormalities in hemostasis occur commonly in small animal patients with cancer, but the incidence of clinical thrombosis or hemorrhage is unknown. Malignancy can lead to abnormalities in both primary and secondary hemostasis, which in turn can lead to either thrombotic or hemorrhagic tendencies. These coagulation abnormalities can be associated with the tumor itself, with anticancer chemotherapy, or with secondary organ dysfunction. Thrombocytopenia and DIC are probably the most common defects associated with clinical bleeding in small animal patients.
authors.affiliation: Department of Veterinary Clinical Sciences, Ohio State University College of Veterinary Medicine, Columbus.
authors.forename: D A
authors.initials: DA
authors.lastname: O'Keefe
authors.forename: C G
authors.initials: CG
authors.lastname: Couto
mesh_terms: D000818:Animals; D001778:Blood Coagulation Disorders / Q000139:chemically induced / Q000209:etiology / Q000662:veterinary*; D001791:Blood Platelet Disorders / Q000209:etiology / Q000662:veterinary; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000662:veterinary; D004283:Dog Diseases; D004285:Dogs; D006487:Hemostasis; D009369:Neoplasms / Q000097:blood / Q000150:complications / Q000662:veterinary*; D013921:Thrombocytopenia / Q000209:etiology / Q000662:veterinary; D013927:Thrombosis / Q000209:etiology / Q000662:veterinary