[Metastatic neuroblastoma: consolidation treatment with 2 courses of high-dose chemotherapy followed by a bone marrow autograft].
Among 62 children over 1 year of age at diagnosis who were treated for stage IV neuroblastoma, 33 entered remission after conventional therapy. They received high-dose chemotherapy and in vitro purged bone marrow transplantation as consolidation therapy. Fifteen patients received one course and 18 two courses. At present, 16/33 grafted patients are alive in CR with a median follow-up of 28 months. Toxicity of this regimen was tolerable. Under this treatment, actuarial disease free survival is improved compared with that observed under conventional therapy.
Hartmann
O
O
Institut Gustave-Roussy, Villejuif, France.
Benhamou
E
E
Beaujean
F
F
Kalifa
C
C
Lejars
O
O
Patte
C
C
Behard
C
C
Flamant
F
F
Thyss
A
A
Deville
A
A
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D002330:Carmustine / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000188:drug therapy / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D011379:Prognosis; D013713:Teniposide / Q000008:administration & dosage; D014182:Transplantation, Autologous
D013713:Teniposide; D008558:Melphalan; D002330:Carmustine
Neuroblastomes métastatiques: traitement de consolidation par deux cures de chimiothérapie lourde suivies d'autogreffe médullaire.