title: Appearance of hybridoma growth factor/interleukin-6 in the serum of mice bearing a methylcholanthrene-induced sarcoma.
abstract: Serum concentrations of hybridoma growth factor/interleukin-6 progressively increased in mice bearing a transplantable methylcholanthrene-induced sarcoma with tumor growth. Elevated HGF/interleukin-6 concentrations were also positively correlated with increased serum concentrations of the hepatic acute phase reactant protein, amyloid P. Daily Indomethacin treatment of sarcoma-bearing mice prolonged survival and reduced the magnitude of the serum amyloid P response, but failed to attenuate either tumor growth or serum HGF/interleukin-6 responses. Since previous studies have demonstrated that neither interleukin-1 nor tumor necrosis factor-alpha can be detected in the serum of these sarcoma-bearing mice, and that HGF/interleukin-6 is a principal mediator of the hepatic acute phase response, we conclude that circulating HGF/interleukin-6 may contribute significantly to the host responses which accompany experimentally-introduced cancer. Furthermore, prostanoid inhibition does not appear to regulate the synthesis and release of HGF/interleukin-6 during tumor growth.
authors.affiliation: Department of Surgery I, University of Gothenburg, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Gelin
authors.forename: L L
authors.initials: LL
authors.lastname: Moldawer
authors.forename: C
authors.initials: C
authors.lastname: Lonnroth
authors.forename: P
authors.initials: P
authors.lastname: deMan
authors.forename: C
authors.initials: C
authors.lastname: Svanborg-Eden
authors.forename: S F
authors.initials: SF
authors.lastname: Lowry
authors.forename: K G
authors.initials: KG
authors.lastname: Lundholm
mesh_terms: D000818:Animals; D007213:Indomethacin / Q000494:pharmacology; D015850:Interleukin-6; D007378:Interleukins / Q000096:biosynthesis*; D051379:Mice; D012513:Sarcoma, Experimental / Q000378:metabolism*; D000683:Serum Amyloid P-Component / Q000097:blood; D013997:Time Factors
chemical_list: D015850:Interleukin-6; D007378:Interleukins; D000683:Serum Amyloid P-Component; D007213:Indomethacin