The effect of FeCl3 on the accumulation of gallium-67 into inflammatory and normal tissues.
The effect of FeCl3 on the uptake of 67Ga by inflammatory and normal tissues was studied to clarify the role of transferrin in 67Ga uptake by inflammatory tissue. The administration of FeCl3 5 min before the injection of 67Ga decreased the uptake of 67Ga by liver and spleen, but had little effect on the uptake of 67Ga by the inflammatory tissue. These results suggest that 67Ga is taken up by normal tissues in a transferrin-bound form but in an unbound form by inflammatory tissue. On the other hand, when FeCl3 was simultaneously injected with 67Ga, the uptake of 67Ga by liver and spleen was markedly increased but the uptake by inflammatory tissue was decreased.
Ohkubo
Y
Y
Department of Radiopharmacy, Tohoku College of Pharmacy, Sendai, Japan.
Araki
S
S
Abe
K
K
Takasu
S
S
Kohno
H
H
Kubodera
A
A
D000818:Animals; D002712:Chlorides; D005290:Ferric Compounds / Q000494:pharmacology*; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics*; D006099:Granuloma / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D002712:Chlorides; D005290:Ferric Compounds; D005710:Gallium Radioisotopes; C024555:ferric chloride