Improvement of vestibular plasticity in the guinea pig with a calcium entry blocker.
The influence of flunarizine on vestibular compensation was investigated in hemilabyrinthectomized guinea pigs. The results showed that the vestibular deficits from hemilabyrinthectomy disappeared more rapidly in the treated animals than in the controls. To elucidate the mechanism by which the drug could affect the compensatory process, further studies on the spontaneous and evoked activity of vestibular nuclei were performed in normal, labyrinthectomized and labyrinthectomized-cerebellectomized animals. These electrophysiological data implied that flunarizine improved the vestibular compensation by inhibiting the receptor and nuclear activities of the intact labyrinth. The drug excited the cerebellar cortex, which modulated the activity of the vestibular nuclei of both sides, restoring the balance disrupted by hemilabyrinthectomy.
Tolu
E
E
Institute of Human Physiology, University of Sassari, Italy.
Mameli
O
O
Caria
M A
MA
Melis
F
F
D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism; D007758:Ear, Inner / Q000601:surgery; D005444:Flunarizine / Q000494:pharmacology*; D006168:Guinea Pigs; D009473:Neuronal Plasticity / Q000187:drug effects*; D014726:Vestibular Nuclei / Q000187:drug effects* / Q000502:physiology; D014722:Vestibule, Labyrinth / Q000378:metabolism
D002135:Calcium-Binding Proteins; D005444:Flunarizine