Gene sequences coding for S-adenosylmethionine decarboxylase are present on human chromosome 6 and the X and are not amplified in colon neoplasia.
Sequences for human S-adenosylmethionine decarboxylase, an enzyme involved in polyamine biosynthesis, which is elevated in tumors, have been localized on chromosome 6 and the X.
Radford
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Department of Surgical Oncology, Roswell Park Memorial Institute, New York State Department of Health, Buffalo 14263.
Eddy
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Haley
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Henry
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Pegg
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Pajunen
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D012437:Adenosylmethionine Decarboxylase / Q000235:genetics*; D000818:Animals; D002262:Carboxy-Lyases / Q000235:genetics*; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D003110:Colonic Neoplasms / Q000201:enzymology / Q000235:genetics*; D003111:Colonic Polyps / Q000201:enzymology / Q000235:genetics; D015342:DNA Probes; D015252:Deoxyribonucleases, Type II Site-Specific; D005784:Gene Amplification; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D009693:Nucleic Acid Hybridization; D011110:Polymorphism, Genetic; D014960:X Chromosome
D015342:DNA Probes; C024388:CTGCAG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific; D002262:Carboxy-Lyases; D012437:Adenosylmethionine Decarboxylase