Evidence for increased absorption of glucose and decreased hepatic extraction of insulin in South African Indians.
It has been previously demonstrated that Indians have an exaggerated insulin response to oral glucose when compared to Africans. In an attempt to determine the reasons for this phenomenon matched groups of Indian and African volunteers were subjected to oral and intravenous glucose tolerance testing. It was concluded that the increased absorption of glucose and reduced hepatic extraction of insulin contributed to the hyperinsulinism in Indians.
Naidoo
C
C
Dept. of Chemical Pathology, Univ. of Natal, South Africa.
Naiker
P
P
Jialal
I
I
Padayachi
T
T
Joubert
S M
SM
D000328:Adult; D044383:Black People; D002096:C-Peptide / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D005947:Glucose / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D007194:India / Q000208:ethnology; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects; D008099:Liver / Q000378:metabolism*; D008297:Male; D013019:South Africa; D013997:Time Factors
D002096:C-Peptide; D007328:Insulin; D005947:Glucose