title: Genetic and environmental influences on behavioral and neurochemical aspects of emotionality in rats.
abstract: Three pairings of rats (two derived from divergent, selective breeding and one from divergent environmental conditions) were compared with regard to behavioral and hormonal parameters. Striking differences were observed: results obtained in our own laboratory as well as those found in a review of the literature pointed to higher emotionality (e.g., increased defecation and corticosterone secretion, etc.) in Roman low-avoidance, Wistar-Kyoto and group-housed rats, as compared to their respective counterparts, Roman high-avoidance, spontaneously hypertensive, and individually housed Wistar rats. Concomitant receptor binding studies reviewed here (3H-diazepam- and 3H-imipramine-binding sites) have revealed, however, less consistent intrapair differences.
authors.affiliation: Psychiatrische Universitätsklinik Basel, Biochem. Labor, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Gentsch
authors.forename: M
authors.initials: M
authors.lastname: Lichtsteiner
authors.forename: H
authors.initials: H
authors.lastname: Feer
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001569:Benzodiazepines / Q000378:metabolism; D004195:Disease Models, Animal; D004644:Emotions; D004777:Environment; D005823:Genetics; D006801:Humans; D001523:Mental Disorders / Q000209:etiology / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains; D011955:Receptors, Drug / Q000502:physiology
chemical_list: D011955:Receptors, Drug; D001569:Benzodiazepines