Amiodarone drug interactions: potential beneficial and adverse effects.
The loading dose and maintenance of so called "resistant" cases by amiodarone oral intake is explained. In cases resistant to amiodarone alone, the combination of this drug is attempted with Class I antiarrhythmic agents. However, this association could interact with these drugs because amiodarone appears to have a definite action on the kinetics of several cardiovascular drugs. The association of amiodarone with a very low dosage of beta-blocking agents preventing interactions also looks promising. These remarks are provided in addition to classical limitations of the association of amiodarone because of pronounced interactions with other nonantiarrhythmic drugs such as warfarin or digitalis, which also should have dosage reduced to prevent side effects.
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Centre de Stimulation Cardiaque et de Rhythmologie, Hopital Jean-Rostand, Paris, France.
D000638:Amiodarone / Q000009:adverse effects / Q000494:pharmacology*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D004347:Drug Interactions; D006801:Humans
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone