Complement activation produced by biomaterials.
The complement-activating potential of biomaterials may be defined by appropriate application of C3a and C5a anaphylatoxin radioimmunoassays. Studies performed with hemodialysis membranes demonstrate that blood contact with these model biomaterials results in complement activation that may be ascribed to specific properties of the material surface. Further delineation of these chemical and physical properties may permit design of biocompatible materials.
Chenoweth
D E
DE
Baxter Healthcare Corporation, Round Lake, IL 60073.
D000706:Anaphylatoxins / Q000032:analysis*; D001672:Biocompatible Materials; D001769:Blood; D003167:Complement Activation; D003176:Complement C3 / Q000032:analysis; D015926:Complement C3a; D003182:Complement C5 / Q000032:analysis; D015936:Complement C5a; D006801:Humans; D010455:Peptides / Q000032:analysis*; D011863:Radioimmunoassay; D013499:Surface Properties
D000706:Anaphylatoxins; D001672:Biocompatible Materials; D003176:Complement C3; D003182:Complement C5; D010455:Peptides; D015926:Complement C3a; D015936:Complement C5a