title: Effect of short course chemotherapy on salivary paracetamol elimination.
abstract: 1. Salivary elimination of paracetamol was studied in six male pulmonary tuberculosis patients on short course chemotherapy. 2. Peak paracetamol concentration showed a steady decrease at the end of first week and continued until the end of the study. 3. The elimination half-life of paracetamol decreased 5 weeks after the therapy with a corresponding increase in the clearance rate. 4. Adjustment of dosage of drugs that are metabolized by the microsomal enzymes may be required in patients on anti-tubercular drug regimen in which rifampicin is included.
authors.affiliation: Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, India.
authors.forename: K
authors.initials: K
authors.lastname: Madhusudanarao
authors.forename: J S
authors.initials: JS
authors.lastname: Bapna
authors.forename: C
authors.initials: C
authors.lastname: Adithan
authors.forename: K
authors.initials: K
authors.lastname: Ray
authors.forename: N
authors.initials: N
authors.lastname: Venkatadri
authors.forename: G L
authors.initials: GL
authors.lastname: Kamatchi
authors.forename: M L
authors.initials: ML
authors.lastname: Seetharaman
authors.forename: P
authors.initials: P
authors.lastname: Bahadur
mesh_terms: D000082:Acetaminophen / Q000493:pharmacokinetics*; D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D008297:Male; D012463:Saliva / Q000378:metabolism*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D000995:Antitubercular Agents; D000082:Acetaminophen