Hepatic amyloidosis presenting as severe intrahepatic cholestasis: a case report and review of the literature.
Although hepatic involvement is common in all forms of amyloidosis, jaundice is infrequent and usually mild. We report a case of a 74-yr-old man with severe intrahepatic cholestasis and hepatic amyloid. The topography of amyloid deposition was unusual, in that deposits were confined predominantly to the portal tract. They appeared as a dense eosinophilic infiltrate that stained with congo red. A review of the English-language literature revealed only 18 prior patients with hepatic amyloid associated with severe intrahepatic cholestasis. The histology of only one of these patients showed a similar distribution of amyloid deposits.
Hoffman
M S
MS
Sarah C. Upham Division of Gastroenterology, New York Medical College, Valhalla.
Stein
B E
BE
Davidian
M M
MM
Rosenthal
W S
WS
D000368:Aged; D000686:Amyloidosis / Q000150:complications* / Q000473:pathology; D002780:Cholestasis, Intrahepatic / Q000209:etiology*; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000473:pathology; D008297:Male