Effectiveness of growth hormone (GH) therapy in GH-deficient children and non-GH-deficient short children.
The growth response during short-term growth hormone (GH) treatment was evaluated in eight prepubertal non-GH-deficient (non-GHD) children and compared with six prepubertal GH-deficient (GHD) patients. Standard doses of GH can improve growth rate in GHD and in some non-GHD patients. In neither group the growth response can be predicted by the acute increase in Thymidine Activity or Somatomedin-C levels. A diagnostic trial of GH treatment may be the only certain method of selecting the short non-GHD patients who may benefit from long-term GH therapy.
Bozzola
M
M
Clinica Pediatrica, II Catt., IRCCS, Policlinico San Matteo, Pavia, Italy.
Cisternino
M
M
Biscaldi
I
I
Maghnie
M
M
Valtorta
A
A
Moretta
A
A
Severi
F
F
D000293:Adolescent; D001827:Body Height / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005240:Feasibility Studies; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy*; D013006:Growth Hormone / Q000097:blood / Q000172:deficiency / Q000627:therapeutic use*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000097:blood; D008297:Male; D013936:Thymidine / Q000097:blood
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D013936:Thymidine