Drug-induced bronchopulmonary pleural disease.
More than 75 drugs are known to have adverse effects on the bronchopulmonary pleural system. Many of these drug reactions are fatal unless they are recognized, administration is stopped, and other measures are instituted. No data exist on the number of adverse drug reactions on the lung, because there is no mandatory reporting system in the United States. Probably less than 5% are reported. The clinician should be aware of the drugs that can produce adverse reactions on the lungs and stop the administration as soon as possible. In this article, I have classified the drugs known to produce adverse pulmonary effects as follows: chemotherapeutic, cardiovascular, antibiotic, and anti-inflammatory agents, drugs known to induce systemic lupus erythematosus, inhalants, illicit drugs such as heroin, and miscellaneous drugs. There are no blood tests or other means of diagnosing adverse drug effects on the lung. Chest roentgenographic findings are nonspecific. Pulmonary function abnormalities generally correlate with the degree of dyspnea and chest roentgenographic changes. Therefore, the clinician trying to explain the onset of pulmonary symptoms must be aware of the drugs the patient is taking.
Rosenow
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Division of Thoracic Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D001982:Bronchial Diseases / Q000139:chemically induced*; D002317:Cardiovascular Agents / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects; D008171:Lung Diseases / Q000139:chemically induced*; D010995:Pleural Diseases / Q000139:chemically induced*
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D002317:Cardiovascular Agents; D013287:Illicit Drugs