[Modulation by quinolones of the in vitro proliferative response of splenic cells of the mouse and IL 1 production].
Besides their antibacterial activity, antibiotics can modulate immune response. In this work, we studied the effects of 6 quinolones (nalidixic and pipemidic acid, pefloxacin, norfloxacin, ofloxacin, ciprofloxacin) on Con A or LPS induced mitogenic response in mice. Data presented here show that pefloxacin and ofloxacin enhanced Con A (1 microgram/ml) induced proliferative response when used at low concentrations (0.1 microgram/ml and 1 microgram/ml). In the same conditions LPS induced response was not modified. When used at high concentrations (greater than 25 micrograms/ml), inhibition of both LPS and Con A induced responses was observed. Con A induced response needs interaction between macrophages and T lymphocytes. So, we investigated whether quinolones could act on interleukin 1 (IL 1) production by macrophages. Our results showed that pefloxacin and ofloxacin, used at low concentrations, enhanced LPS induced IL 1 production by macrophages.
Guenounou
M
M
Laboratoire de Microbiologie, Hôpital R. Poincaré, Garches.
Ronco
E
E
Kodari
E
E
Vacheron
F
F
Momrikof
V
V
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002455:Cell Division; D002478:Cells, Cultured; D002939:Ciprofloxacin / Q000494:pharmacology; D007375:Interleukin-1 / Q000096:biosynthesis*; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009268:Nalidixic Acid / Q000494:pharmacology; D009643:Norfloxacin / Q000031:analogs & derivatives / Q000494:pharmacology; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology; D015366:Pefloxacin; D010876:Pipemidic Acid / Q000494:pharmacology; D013154:Spleen / Q000166:cytology* / Q000276:immunology
D000890:Anti-Infective Agents; D007375:Interleukin-1; D010078:Oxazines; D015366:Pefloxacin; D009268:Nalidixic Acid; D002939:Ciprofloxacin; D015242:Ofloxacin; D010876:Pipemidic Acid; D009643:Norfloxacin
Modulation de la résponse proliférative in vitro des cellules spléniques de souris et de la production d'IL 1 par les quinolones.