title: Evidence for discrete alterations in central cardiovascular catecholamine and neuropeptide Y immunoreactive neurons in aged male rats and in genetically hypertensive male rats of the Lyon strain.
abstract: A computer-assisted morphometrical and microdensitometrical analysis has been performed on cardiovascular noradrenaline (NA), adrenaline (A) and neuropeptide (Y (NPY) neurons in adult and 24-month-old male rats and on hypotensive (LL), normotensive (LN) and hypertensive (LH) male rats of the Lyon strain using the indirect immunoperoxidase procedures. It was found that in NPY/phenylethanolamine-N-methyltransferase (PNMT) costoring neurons of the CI area of the rostral medulla oblongata NPY-like immunoreactivity showed a more marked reduction than the PNMT immunoreactivity. Furthermore, within the parvocellular part of the paraventricular hypothalamic nucleus. NPY immunoreactive nerve terminal profiles were much more affected than the PNMT immunoreactive profiles during aging as revealed by a marked reduction in the number of profiles and by a marked reduction of absorbency values in the microdensitometrical analysis. Thus, in the NPY/PNMT costoring neurons of the A C1 group of the ventrolateral medulla projecting, for example, to the hypothalamus, the peptide transmission line may have a special vulnerability to the aging processes which may contribute to the development of hypertension in old people in view of a vasodepressor role of many central NPY/PNMT neurons. An extensive morphometrical and microdensitometrical analysis of the various catecholamine (CA) cell groups of the medulla oblongata of the LL, LN and LH rats of the Lyon strain was performed. In a comparison between LL and LH rats the A2 cell group of the LH strain showed a trend for an increase in the mean tyrosine hydroxylase (TH) immunoreactive cell body area and the C3 group showed a significant increase in the number of PNMT immunoreactive profiles.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.forename: K
authors.initials: K
authors.lastname: Fuxe
authors.forename: L F
authors.initials: LF
authors.lastname: Agnati
authors.forename: I
authors.initials: I
authors.lastname: Kitayama
authors.forename: M
authors.initials: M
authors.lastname: Zoli
authors.forename: A M
authors.initials: AM
authors.lastname: Janson
authors.forename: A
authors.initials: A
authors.lastname: Härfstrand
authors.forename: M
authors.initials: M
authors.lastname: Vincent
authors.forename: M
authors.initials: M
authors.lastname: Kalia
authors.forename: M
authors.initials: M
authors.lastname: Goldstein
authors.forename: J
authors.initials: J
authors.lastname: Sassard
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D002395:Catecholamines / Q000032:analysis*; D003720:Densitometry; D006973:Hypertension / Q000473:pathology*; D007124:Immunoenzyme Techniques; D008297:Male; D008526:Medulla Oblongata / Q000473:pathology*; D009474:Neurons / Q000032:analysis / Q000473:pathology; D009478:Neuropeptide Y / Q000032:analysis*; D010625:Phenylethanolamine N-Methyltransferase / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002395:Catecholamines; D009478:Neuropeptide Y; D010625:Phenylethanolamine N-Methyltransferase