Beta 2 microglobulin expression in keratoacanthomas and squamous cell carcinoma.
The cell surface expression of beta-2-microglobulin (beta 2 M) was investigated in 33 keratoacanthomas (KA) and 58 squamous cell carcinomas (SCC) to determine whether this antigen was expressed to a different extent in these two conditions and, thus, whether this constitutes a reliable and practical test for distinguishing them. Loss of beta 2 M expression was not a reliable feature for distinguishing between KA and SCC and seemed to be related more to the degree of cellular differentiation and maturation, than to malignancy as such.
Graham
R M
RM
University Department of Dermatology, Liverpool University, U.K.
MacFarlane
A W
AW
Curley
R K
RK
Nash
J R
JR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000954:Antigens, Surface / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007636:Keratoacanthoma / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology; D001613:beta 2-Microglobulin / Q000276:immunology*
D000954:Antigens, Surface; D001613:beta 2-Microglobulin