[In vitro antifungal activity of nitroxoline. Preliminary clinical results].
Nitroxoline is an oxyquinoline derivative with a large antifungical activity. The fungistatic activity of nitroxoline is greater against Candida albicans than against Torulopsis glabrata, Candida tropicalis and Candida krusei. The MIC are compatible with urinary concentrations of nitroxoline. These preliminary clinical results favor the use of nitroxoline in the management of fungal urinary tract infections.
Cancet
B
B
Laboratoire de Biologie, Centre Hospitalier Saint-Cyr, Villeneuve-sur-Lot.
Amgar
A
A
D000368:Aged; D000369:Aged, 80 and over; D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D009600:Nitroquinolines / Q000494:pharmacology* / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000892:Anti-Infective Agents, Urinary; D000935:Antifungal Agents; D009600:Nitroquinolines; C005308:nitroxoline
Activité antifongique de la nitroxoline in vitro. Résultats cliniques préliminaires.