title: Unilateral vesicoureteral reflux in children. study on urine specific gravity, osmolality, beta-2-microglobulin and lactoferrin.
abstract: Vesicoureteral reflux was defined as unilateral in 17 of 36 cases. Urine was collected from both kidneys. Urine specific gravity and osmolality were significantly reduced; beta 2-microglobulin was elevated and lactoferrin depressed on the reflux side. We also observed a significant correlation between specific gravity or osmolality on one side and lactoferrin on the other side, and between osmolality and beta 2-microglobulin. These observations showed a depressed concentrating capacity and reduced tubular absorption of beta 2-microglobulin suggesting reduced tubular function on the reflux side.
authors.affiliation: Department of Pediatrics, University Hospital, Tromsø, Norway.
authors.forename: T J
authors.initials: TJ
authors.lastname: Gutteberg
authors.forename: P
authors.initials: P
authors.lastname: Strømme
authors.forename: J
authors.initials: J
authors.lastname: Saebø-Larsen
authors.forename: T
authors.initials: T
authors.lastname: Flaegstad
mesh_terms: D002648:Child; D006801:Humans; D007684:Kidney Tubules / Q000503:physiopathology; D007781:Lactoferrin / Q000652:urine*; D007782:Lactoglobulins / Q000652:urine*; D009994:Osmolar Concentration; D013046:Specific Gravity; D014718:Vesico-Ureteral Reflux / Q000503:physiopathology / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine*
chemical_list: D007782:Lactoglobulins; D001613:beta 2-Microglobulin; D007781:Lactoferrin