title: Ultrastructural studies on the interaction of Plasmodium falciparum ookinetes with the midgut epithelium of Anopheles stephensi mosquitoes.
abstract: The interaction of Plasmodium falciparum ookinetes with the midgut epithelium of Anopheles stephensi is described by electron microscopy. Plasmodium falciparum ookinetes have been traced during the early stages of invasion and localization beneath the basal lamina of the midgut. It is generally assumed that ookinetes break through two membranes to reach the basal lamina of the midgut epithelium by an intracellular route. In the present study evidence is presented that the ookinete takes an intercellular route in traversing the epithelial layer. Compared to the mode of penetration and intracellular development of sporozoites and merozoites, an intercellular route for penetration of the ookinete is not inconsistent with its further extracellular development.
authors.affiliation: Department of Medical Parasitology, University of Nijmegen, The Netherlands.
authors.forename: J F
authors.initials: JF
authors.lastname: Meis
authors.forename: T
authors.initials: T
authors.lastname: Ponnudurai
mesh_terms: D000818:Animals; D000852:Anopheles / Q000469:parasitology*; D006790:Host-Parasite Interactions; D008854:Microscopy, Electron; D010963:Plasmodium falciparum / Q000502:physiology* / Q000648:ultrastructure