title: Mathematical model of Klebsiella pneumoniae resistance to amikacin and gentamicin.
abstract: 1. The resistance of Klebsiella pneumoniae to amikacin and gentamicin was studied by a mathematical model to predict the rate of sensitivity decrease. The results accurately matched experimental data, showing that the model is a reliable predicting tool. 2. The observations were carried out over six years and included 2677 cultures that were positive for K. pneumoniae. At the beginning of the observation period, 85.7% of the cultures were sensitive to amikacin and 40.8% were sensitive to gentamicin. Sensitivity to amikacin showed a surprisingly rapid decrease; at the end of the experimental period, amikacin and gentamicin sensitivities were 33.3% and 27.8%, respectively. 3. We conclude that patterns of resistance of other bacteria could be investigated using this method.
authors.affiliation: Departamento de Patologia e Hospital das Clínicas, Faculdade de Medicina, Universìdade de São Paulo, Brasil.
authors.forename: M A
authors.initials: MA
authors.lastname: Nicolelis
authors.forename: E
authors.initials: E
authors.lastname: Massad
authors.forename: R U
authors.initials: RU
authors.lastname: Hutzler
authors.forename: A
authors.initials: A
authors.lastname: Engel
authors.forename: E
authors.initials: E
authors.lastname: Rodrigues
authors.forename: J C
authors.initials: JC
authors.lastname: Bazzone
authors.forename: M
authors.initials: M
authors.lastname: Tomida
mesh_terms: D000583:Amikacin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology*; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008962:Models, Theoretical
chemical_list: D005839:Gentamicins; D000583:Amikacin