title: [Chromosome aberrations and malignant lymphomas].
abstract: Chromosomal findings in malignant lymphomas are correlated to the histopathology and the immunologic phenotype of lymphoma subgroups. The prognostic significance of a cytogenetic analysis and its value for therapy planning are discussed. With respect to tumorigenesis it is emphasized that a number of proto-oncogenes and genes for cell differentiation, such as immunoglobulin and T-cell receptor genes, have been localized at sites of recurring chromosomal rearrangements. One chapter deals with cytogenetic data in correlation to findings of DNA recombination studies in Hodgkin's disease.
authors.affiliation: Institut für Humangenetik, Medizinische Universität zu Lübeck.
authors.forename: C
authors.initials: C
authors.lastname: Fonatsch
authors.forename: G
authors.initials: G
authors.lastname: Gradl
mesh_terms: D002869:Chromosome Aberrations; D006689:Hodgkin Disease / Q000235:genetics*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D011379:Prognosis; D011519:Proto-Oncogenes
vernacular_title: Chromosomenaberrationen und maligne Lymphome.