title: Failla memorial lecture. Risk, research, and radiation protection.
abstract: Radiation protection concerns the risk of stochastic late effects, especially cancer, and limits on radiation exposure both occupationally and for the public tend to be based on these risks. The risks are determined, mainly by expert committees, from the steadily growing information on exposed human populations, especially the survivors of the atomic bombs dropped in Japan in 1945. Risks of cancer estimated up to the early 1980s were in the range 1 to 5 X 10(-2)/Sv, but recent revisions in the dosimetry of the Japanese survivors and additional cycles of epidemiological information suggest values now probably at the high end of this range. These are likely to require an increase in the values used for radiation protection. A major problem with risk estimation is that data are available only for substantial doses and must be extrapolated down to the low-dose region of interest in radiation protection. Thus the shape of the dose-response curve is important, and here we must turn to laboratory research. Of importance are studies involving (1) dose rate, which affects the response to low-LET radiation and often to high-LET radiation as well; (2) radiation quality, since the shapes of the dose-response curves for high- and low-LET radiation differ and thus the RBE, the ratio between them, varies, reaching a maximum value RBEM at low doses; and (3) modifiers of the carcinogenic response, which either enhance or reduce the effect of a given dose. Radiation protection depends both on risk information, and especially also on comparisons with other occupational and public risks, and on research, not only for extrapolations of risk to low doses but also in areas where human information is lacking such as in the effects of radiation quality and in modifications of response.
authors.affiliation: National Council on Radiation Protection and Measurements, Bethesda, Maryland 20814.
authors.forename: W K
authors.initials: WK
authors.lastname: Sinclair
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects; D006801:Humans; D051379:Mice; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D011830:Radiation Effects; D011835:Radiation Protection; D011878:Radiotherapy / Q000009:adverse effects; D012306:Risk