[Prevention of thromboembolism in accident surgery--angiospastic complications with DHE-heparin. A multicenter study].
In immobilized patients different drugs are used for thromboembolism prophylaxis. Arterial vasospastic complications have recently been reported after Heparin-DHE. In our clinical observation five of these cases were treated. A multicenter study was performed in 82 Austrian trauma units investigating the incidence and outcome of complications of Heparin DHE prophylaxis. 147,290 patients had different drugs for thromboembolism prophylaxis. 61,092 got Heparin-DHE. Complications could be observed at 142 patients but only in the group receiving Heparin DHE. 135 cases were treated conservatively (amputation of limbs became necessary in seven patients). In seven other cases immediate operative exposure of the vessels and balloon catheter dilatation was successfully performed. Vasospasm occurred only in patients with Heparin DHE prophylaxis. It is important to realize this possibility, so that early therapeutic measurements can be taken to avoid unnecessary permanent ischaemic damages and limb amputation.
Gatterer
R
R
I. Universitätsklinik für Unfallchirurgie, Wien.
Wruhs
O
O
Havelec
L
L
Polterauer
P
P
Marosi
L
L
D002986:Clinical Trials as Topic; D004087:Dihydroergotamine / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations / Q000008:administration & dosage / Q000009:adverse effects; D005121:Extremities / Q000098:blood supply*; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006495:Heparin, Low-Molecular-Weight; D006801:Humans; D007511:Ischemia / Q000139:chemically induced* / Q000628:therapy; D011183:Postoperative Complications / Q000517:prevention & control; D013923:Thromboembolism / Q000517:prevention & control*; D014661:Vasoconstriction / Q000187:drug effects*; D014947:Wounds and Injuries / Q000601:surgery*
D004338:Drug Combinations; D006495:Heparin, Low-Molecular-Weight; C031388:heparin-dihydergot; D004087:Dihydroergotamine; D006493:Heparin
Thromboembolieprophylaxe in der Unfallchirurgie--angiospastische Komplikationen bei DHE-Heparin. Eine multizentrische Erhebung.