title: CV-1, a new antibiotic produced by a strain of Streptomyces sp. I. Fermentation, isolation and biological properties of the antibiotic.
abstract: A new antibiotic, CV-1, was isolated from the culture broth of a Streptomyces sp. by various chromatographies. CV-1 showed antibacterial activity against Escherichia coli in cooperation with spiramycin, a macrolide antibiotic. The mode of action of CV-1 seemed to be the inhibition of lipopolysaccharide synthesis.
authors.forename: M
authors.initials: M
authors.lastname: Ichimura
authors.forename: T
authors.initials: T
authors.lastname: Koguchi
authors.forename: T
authors.initials: T
authors.lastname: Yasuzawa
authors.forename: F
authors.initials: F
authors.lastname: Tomita
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D002845:Chromatography; D004347:Drug Interactions; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D005285:Fermentation; D005944:Glucosamine / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D007933:Leucomycins / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000096:biosynthesis; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D007933:Leucomycins; D008070:Lipopolysaccharides; C053067:1,2-diamino-1,2-N,N'-carbonyl-1,2-dideoxyglucose hydrate; D005944:Glucosamine