title: Comparison of body composition, adipocyte size, and glucose and insulin concentrations in Pima Indian and Caucasian children.
abstract: Pima Indian adults with normal glucose tolerance have higher plasma glucose and insulin concentrations than Caucasian adults. To estimate the age of onset of these differences, and to assess their relationship to abdominal and gluteal adipocyte size, we measured adiposity, adipocyte size, and glucose and insulin concentrations during a glucose tolerance test in lean (less than 20% body fat), prepubertal children from each race. The Pima (n = 13) and Caucasian (n = 10) groups were of similar age, percent body fat, and weight. Pima Indian children had higher fasting glucose (101 +/- 2 v 94 +/- 2 mg/dL, P = .01) and insulin (22 +/- 2 v 15 +/- 2 microU/mL, P less than .01) concentrations and larger abdominal adipocytes (0.49 +/- 0.03 v 0.37 +/- 0.04 microgram lipid/cell, P less than .05) than the Caucasian children. Postprandial glucose and insulin concentrations and gluteal adipocyte size were similar in the two races. The higher plasma glucose and insulin concentrations found in Pima adults are present in lean Pima children, and are associated with increased abdominal adipocyte size. These increases may precede the development of obesity in this racial group.
authors.forename: W G
authors.initials: WG
authors.lastname: Abbott
authors.forename: J E
authors.initials: JE
authors.lastname: Foley
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D001130:Arizona; D001786:Blood Glucose / Q000032:analysis*; D001823:Body Composition; D002648:Child; D005215:Fasting; D006801:Humans; D006946:Hyperinsulinism / Q000453:epidemiology; D007198:Indians, North American; D007328:Insulin / Q000097:blood*; D044465:White People
chemical_list: D001786:Blood Glucose; D007328:Insulin