Hepoxilins, potential endogenous mediators of insulin release.
Evidence is presented to show that pancreatic islets of Langerhans are capable of producing hepoxilins A3 and B3 from endogenous substrates as well as 14C-labeled 12-HPETE. Both hepoxilins are active in stimulating the release of insulin from these cells in the presence of 10 mM glucose. These experiments suggest that the hepoxilins may participate as potential endogenous mediators of insulin release in islets of Langerhans.
Pace-Asciak
C R
CR
Research Institute, Hospital for Sick Children, Toronto, Canada.
Martin
J M
JM
Corey
E J
EJ
D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives / Q000378:metabolism*; D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D006893:Hydroxyeicosatetraenoic Acids / Q000378:metabolism*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D007515:Islets of Langerhans / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D005231:Fatty Acids, Unsaturated; D006893:Hydroxyeicosatetraenoic Acids; D007328:Insulin; C049211:hepoxilin B4; C049210:hepoxilin A4; C022948:10-hydroxy-11,12-epoxyeicosa-5,8,14-trienoic acid; C038243:8-hydroxy-11,12-epoxyeicosa-5,9,14-trienoic acid; D015126:8,11,14-Eicosatrienoic Acid