title: [The mouse paw edema test for titrating Shigella toxin and antitoxin and for determining the safety of the anatoxin].
abstract: The method for the titration of Shigella dysenteriae I neurotoxin, toxoid prepared from this toxin and different antitoxic preparations in the mouse paw edema test has been developed. The quantitative determination of antitoxin is based on the neutralization test. The conditions of titration (the dilutions of the neurotoxin and the neutralization doses of the antitoxin), as well as criteria for the evaluation of the positive or negative results, have been established.
authors.forename: N B
authors.initials: NB
authors.lastname: Kamzolkina
authors.forename: A V
authors.initials: AV
authors.lastname: Volkov
mesh_terms: D000818:Animals; D000992:Antitoxins / Q000276:immunology*; D003126:Colostrum / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004487:Edema / Q000139:chemically induced*; D005260:Female; D005528:Foot; D006041:Goats / Q000276:immunology; D007114:Immunization; D051379:Mice; D008892:Milk / Q000276:immunology; D009498:Neurotoxins / Q000276:immunology*; D009500:Neutralization Tests / Q000379:methods; D012762:Shigella dysenteriae; D014121:Toxoids / Q000276:immunology*
chemical_list: D000992:Antitoxins; D009498:Neurotoxins; D014121:Toxoids
vernacular_title: Test oteka lapy myshi dlia titrovaniia shigelleznogo toksina, antitoksina i opredeleniia bezvrednosti anatoksina.