title: Expression of restricted immunoglobulin isotypes in plasmacellular hyperplasia after allogeneic bone marrow transplantation.
abstract: Plasmacellular hyperplasia in lymphoid tissue was found in 4 out of 9 patients 1-6 months after allogeneic bone marrow transplantation as treatment for leukaemia. In the plasma cell populations, 13-85% expressed a single immunoglobulin light and heavy chain isotype (monotypic Ig expression). DNA analysis, using a DNA probe specific for heavy chain JH gene segments and for light chains, did not reveal the presence of clonally restricted B lymphocytes. The patients' sera lacked homogeneous immunoglobulins. We conclude that plasmacellular hyperplasia found after allogeneic bone marrow transplantation represents a polyclonal B-cell expansion- with a restriction in Ig isotype.
authors.affiliation: Department of Internal Medicine, University Hospital, Utrecht, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: Schuurman
authors.forename: R W
authors.initials: RW
authors.lastname: Hendriks
authors.forename: L F
authors.initials: LF
authors.lastname: Verdonck
authors.forename: J
authors.initials: J
authors.lastname: van Baarlen
authors.forename: G C
authors.initials: GC
authors.lastname: de Gast
authors.forename: R K
authors.initials: RK
authors.lastname: Schuurman
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D016026:Bone Marrow Transplantation; D004247:DNA / Q000032:analysis; D006087:Graft vs Host Reaction; D006801:Humans; D006965:Hyperplasia; D007132:Immunoglobulin Isotypes / Q000032:analysis*; D008198:Lymph Nodes / Q000473:pathology; D008221:Lymphoid Tissue / Q000473:pathology*; D008223:Lymphoma / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology*; D014184:Transplantation, Homologous
chemical_list: D007132:Immunoglobulin Isotypes; D004247:DNA