The effect of E. coli infection on the prostaglandin synthesizing capacity of postobstructive rat kidney.
The PGE2, PGI2, PGF2 alpha and TxA2 synthesizing activities were studied in an isolated microsomal fraction of rat kidney after temporary, unilateral ureter obstruction and E. coli infection. In the early phase of regeneration the synthesis of vasodilatory PGI2 was increased, whereas that of vasoconstrictory PGF2 alpha was decreased. An increased PGE2 synthesizing activity was observed when renal obstruction was associated with infection. The role of these changes in regenerating the haemodynamics and function of postobstructive kidney is discussed.
Sallai
J
J
Túri
S
S
Falkay
G
G
D000818:Animals; D015237:Dinoprost; D015232:Dinoprostone; D011464:Epoprostenol / Q000096:biosynthesis; D004927:Escherichia coli Infections / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000378:metabolism*; D011449:Prostaglandin Endoperoxides / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis; D011462:Prostaglandins G / Q000096:biosynthesis*; D051381:Rats; D013928:Thromboxane A2 / Q000096:biosynthesis*; D014517:Ureteral Obstruction / Q000378:metabolism*
D011449:Prostaglandin Endoperoxides; D011458:Prostaglandins E; D011460:Prostaglandins F; D011462:Prostaglandins G; D013928:Thromboxane A2; D015237:Dinoprost; D011464:Epoprostenol; D015232:Dinoprostone