title: Comparison of inhaled metaproterenol, inhaled atropine sulfate, and their combination in treatment of children with acute asthma.
abstract: The separate and combined effects of inhaled metaproterenol and atropine sulfate were evaluated in the treatment of 44 episodes of acute asthma occurring in 35 children ranging in age from 13 months to 13 years. Peak expiratory flow rate and pulmonary index were measured before and after each of up to three inhalation treatments. Significant improvement in peak flow rate (P less than .04) was noted after the second inhalation of metaproterenol both with and without the combination of atropine sulfate compared with the effects of atropine alone. Patients treated with metaproterenol and metaproterenol combined with atropine also experienced fewer therapeutic failures (2/15 and 2/16, respectively) compared with those treated with atropine (6/13, P less than .02). Pulmonary index scores did not differ among the treatment groups. Inhaled metaproterenol appears to be more effective than inhaled atropine sulfate in the treatment of children with acute asthma. The addition of inhaled atropine sulfate appears to offer no advantage over treatment with inhaled metaproterenol alone.
authors.affiliation: Department of Pediatrics, Medical College of Georgia, Augusta.
authors.forename: M F
authors.initials: MF
authors.lastname: Guill
authors.forename: M J
authors.initials: MJ
authors.lastname: Maloney
authors.forename: R H
authors.initials: RH
authors.lastname: DuRant
mesh_terms: D000208:Acute Disease; D000280:Administration, Inhalation; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001285:Atropine / Q000008:administration & dosage*; D001986:Bronchial Spasm / Q000188:drug therapy / Q000503:physiopathology; D002648:Child; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D009921:Metaproterenol / Q000008:administration & dosage*; D010366:Peak Expiratory Flow Rate; D011897:Random Allocation; D012135:Respiratory Sounds
chemical_list: D009921:Metaproterenol; D001285:Atropine