title: Retinoblastoma, chromosome abnormalities and oncogene expression.
abstract: Recurrent chromosomal abnormalities in retinoblastomas involve numbers 13, 1, and 6, as well as homogeneously staining regions (HSR) and double minutes (DMS). Evidence suggesting that chromosome 13 contains a gene responsible for tumorigenesis has already been presented. We postulate that the genetic changes resulting from abnormalities of chromosomes 1 and 6 and the HSR/DMS provide a selective growth advantage to cells in which they occur. Support for this hypothesis, as it relates to the HSR/DMS and oncogene amplification, is discussed.
authors.forename: F
authors.initials: F
authors.lastname: Gilbert
authors.forename: V R
authors.initials: VR
authors.lastname: Potluri
authors.forename: M P
authors.initials: MP
authors.lastname: Short
authors.forename: C L
authors.initials: CL
authors.lastname: Kau
authors.forename: F
authors.initials: F
authors.lastname: Lalatta
mesh_terms: D002869:Chromosome Aberrations / Q000235:genetics*; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002878:Chromosomes, Human, Pair 1; D002882:Chromosomes, Human, Pair 13; D002896:Chromosomes, Human, Pair 6; D005134:Eye Neoplasms / Q000235:genetics*; D006801:Humans; D009857:Oncogenes; D012175:Retinoblastoma / Q000235:genetics*