Deletion of c-fms sequences in the 5q- syndrome.
Southern blot analyses demonstrated hemizygosity of c-fms sequences in three cases of the 5q- syndrome, cytogenetically characterized by del(5)(q13;q35) or del(5)(q31;q35). In situ hybridization studies revealed a deletion of this oncogene from the 5q- chromosome in two cases; moreover, we localized c-fms to region 5q31-33.
Bartram
C R
CR
Department of Pediatrics II, University of Ulm, Federal Republic of Germany.
Böhlke
J V
JV
Adolph
S
S
Hameister
H
H
Ganser
A
A
Anger
B
B
Heisterkamp
N
N
Groffen
J
J
D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes
D011518:Proto-Oncogene Proteins