[Contrary action of khingamin on the rejection of a skin allograft and on the level of antibody-producing cells in mice].
The effect of antimalarial drug khingamin preinjection on skin allograft rejection and the level of antibody forming cells (AFC) in Jerne reaction has been investigated. The drug at the doses of 30, 40, 50 mg/kg inhibited skin allograft rejection. The dose of 20 mg/kg proved ineffective. A single preinjection at a dose of 20 mg/kg had a stimulating effect on antibody formation, whereas the dose of 40 mg/kg induced no effect. When the latter dose was injected simultaneously with sheep red blood cells, it caused a significant inhibition of AFC levels. Fourfold preliminary injection of khingamin at doses 40 and 20 mg/kg had a stimulating effect. The reverse effect of khingamin may be accounted for by the diverse action of the drug itself and its metabolites.
Gamburg
L Iu
LIu
Cheredeev
A N
AN
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects*; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology; D006084:Graft Rejection / Q000187:drug effects*; D007114:Immunization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D016038:Skin Transplantation; D013997:Time Factors; D014184:Transplantation, Homologous
D000962:Antimalarials; C023676:chloroquine diphosphate; D002738:Chloroquine
Oppozitnoe deĭstvie khingamina na ottorzhenie kozhnogo allotransplantata i na uroven' antiteloobrazuiushchikh kletok u mysheĭ.