title: Immunoregulatory properties of synthetic peptides, fragments of a proline-rich polypeptide (PRP) from ovine colostrum.
abstract: It has been previously found that a proline-rich polypeptide (PRP) isolated from ovine colostrum has a regulatory effect on the immune response. A nonapeptide fragment Val-Glu-Ser-Tyr-Val-Pro-Leu-Phe-Pro was isolated from the chymotryptic digest of PRP. The nonapeptide showed biological activity similar to PRP. The determined amino acid sequence was now confirmed by synthesis. Synthetic nonapeptide as well as its C-terminal hexapeptide, Tyr-Val-Pro-Leu-Phe-Pro, showed biological activity similar to PRP and the nonapeptide obtained from PRP.
authors.affiliation: Department of Immunochemistry, Polish Academy of Sciences, Wrocław, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Janusz
authors.forename: Z
authors.initials: Z
authors.lastname: Wieczorek
authors.forename: K
authors.initials: K
authors.lastname: Spiegel
authors.forename: A
authors.initials: A
authors.lastname: Kubik
authors.forename: Z
authors.initials: Z
authors.lastname: Szewczuk
authors.forename: I
authors.initials: I
authors.lastname: Siemion
authors.forename: J
authors.initials: J
authors.lastname: Lisowski
mesh_terms: D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D003126:Colostrum / Q000276:immunology*; D005260:Female; D006462:Hemolytic Plaque Technique; D051379:Mice; D008808:Mice, Inbred CBA; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000276:immunology*; D010455:Peptides / Q000276:immunology*; D055232:Proline-Rich Protein Domains; D012756:Sheep
chemical_list: D010446:Peptide Fragments; D010455:Peptides