Non-ketotic hyperglycinaemia: clinical and biochemical aspects.
Non-ketotic hyperglycinaemia is an autosomal recessive disorder of glycine metabolism characterized by elevated concentrations of glycine in plasma, urine and cerebrospinal fluid. The fundamental defect was found to lie in the glycine cleavage system. It is of significance that the major pathway for the catabolism of glycine was elucidated through the studies of hyperglycinaemia. The present knowledge about non-ketotic hyperglycinaemia is described in clinical and biochemical aspects.
Tada
K
K
Hayasaka
K
K
D000592:Amino Acid Metabolism, Inborn Errors / Q000235:genetics* / Q000378:metabolism; D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D003937:Diagnosis, Differential; D004569:Electroencephalography; D005808:Genes, Recessive; D005998:Glycine / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007662:Ketosis / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009097:Multienzyme Complexes / Q000378:metabolism*; D014166:Transferases / Q000378:metabolism*
D002352:Carrier Proteins; D009097:Multienzyme Complexes; C064525:glycine cleavage system; D000594:Amino Acid Oxidoreductases; D014166:Transferases; D005998:Glycine