[Significance of clinical and biological markers in autistic syndromes in children].
Several biological theories were proposed to explain symptoms of childhood autism in terms of monoamine metabolic dysfunction. Clinical, electrophysiological and biochemical markers which support the dopaminergic hypothesis will be given in this paper. A factorial analysis, performed on the 'behavior summarized evaluation' (BSE, scoring behavioral data), exhibits a first component corresponding to the autistic DSM III criteria, and also shows that the disturbances of attention and perception belonged to this component. So, as well as communication, selective attention, perception and gestures, usually considered as regulated by the dopaminergic system are deeply modified and appeared as primary symptoms in autistic syndromes. Many electrophysiological data recorded in autistic children suggest both faulty modulation of sensory input and deficiency in dealing with sensory cross-modal association which have been related to a dysfunctioning of the dopaminergic system. Elevated homovanillic acid levels, the main dopamine metabolite, have been attributed to a reduced re-uptake of dopamine related to a 'longer occupation' of the receptors which is in agreement with the electrophysiological 'sensory overload'. The relationships found between these markers are discussed. Such an approach would contribute to a better understanding of the underlying mechanism of autism.
Martineau
J
J
Laboratoire de Neurophysiologie et de Thérapeutique en Pédopsychiatrie, CHU Bretonneau, Tours, France.
Bruneau
N
N
Garreau
B
B
Barthélémy
C
C
Muh
J P
JP
Lelord
G
G
D001321:Autistic Disorder / Q000378:metabolism* / Q000523:psychology; D002648:Child; D002652:Child Behavior; D002675:Child, Preschool; D004298:Dopamine / Q000378:metabolism*; D004569:Electroencephalography; D005071:Evoked Potentials; D006719:Homovanillic Acid / Q000652:urine; D006801:Humans
D004298:Dopamine; D006719:Homovanillic Acid
Intérêt des marqueurs cliniques et biologiques dans les syndromes autistiques de l'enfant.