title: Pulmonary arterial transit times.
abstract: To begin to characterize the pulmonary arterial transport function we rapidly injected a bolus containing a radiopaque dye and a fluorescence dye into the right atrium of anesthetized dogs. The concentrations of the dye indicators were measured in the main pulmonary artery (fluoroscopically) and in a subpleural pulmonary arteriole (by fluorescence microscopy). The resulting concentration vs. time curves were subjected to numerical deconvolution and moment analysis to determine how the bolus was dispersed as it traveled through the arteriole stream tube from the main pulmonary artery to the arteriole. The mean transit time and standard deviation of the transport function from the main pulmonary artery to the arterioles studied averaged 1.94 and 1.23 s, respectively, and the relative dispersion (ratio of standard deviation to mean transit time) was approximately 64%. This relative dispersion is at least as large as those reported for the whole dog lung, indicating that relative to their respective mean transit times the dispersion upstream from the arterioles is comparable to that taking place in capillaries and/or veins. The standard deviations of the transport functions were proportional to their mean transit times. Thus the relative dispersion from the main pulmonary artery to the various arterioles studied was fairly consistent. However, there were variations in mean transit time even between closely adjacent arterioles, suggesting that variations in mean transit times between arteriole stream tubes also contribute to the dispersion in the pulmonary arterial tree.
authors.affiliation: Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.
authors.forename: C A
authors.initials: CA
authors.lastname: Dawson
authors.forename: R L
authors.initials: RL
authors.lastname: Capen
authors.forename: L P
authors.initials: LP
authors.lastname: Latham
authors.forename: W L
authors.initials: WL
authors.lastname: Hanson
authors.forename: S E
authors.initials: SE
authors.lastname: Hofmeister
authors.forename: T A
authors.initials: TA
authors.lastname: Bronikowski
authors.forename: D A
authors.initials: DA
authors.lastname: Rickaby
authors.forename: W W
authors.initials: WW
authors.lastname: Wagner
mesh_terms: D000818:Animals; D001160:Arterioles / Q000378:metabolism; D001692:Biological Transport; D004285:Dogs; D005456:Fluorescent Dyes; D007201:Indicator Dilution Techniques; D008954:Models, Biological; D011651:Pulmonary Artery / Q000378:metabolism*; D011652:Pulmonary Circulation; D013997:Time Factors
chemical_list: D005456:Fluorescent Dyes