S-100 beta positive human T lymphocytes: their characteristics and behavior under normal and pathologic conditions.
The characteristics of human S-100 beta-positive T lymphocytes (S-100 beta+ T cells) and their fluctuation in peripheral blood under normal and various pathologic conditions were investigated. S-100 beta+ T cells were small lymphocytes with no particular subcellular structures and showed a proliferative response to mitogens. They were present mainly in peripheral blood under normal conditions but accumulated in T zones of lymph nodes with nonspecific T-zone hyperplasia, where numerous interdigitating reticulum cells existed. In healthy adults approximately 1% to 4% (mean 3.4%) of peripheral blood mononuclear cells were S-100 beta+ T cells. The proportion of S-100 beta+ T cells in peripheral blood tended to significantly decrease (less than 0.5%) in patients with neoplastic diseases; this tendency was apparently related to tumor progression.
Takahashi
K
K
Yoshino
T
T
Hayashi
K
K
Sonobe
H
H
Ohtsuki
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000032:analysis*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology; D009414:Nerve Growth Factors; D011951:Receptors, Complement / Q000032:analysis; D011961:Receptors, Fc / Q000032:analysis; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000032:analysis* / Q000276:immunology; D013274:Stomach Neoplasms / Q000097:blood; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000648:ultrastructure
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D008934:Mitogens; D009414:Nerve Growth Factors; D011951:Receptors, Complement; D011961:Receptors, Fc; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins