title: Delayed hypersensitivity responses in children after local cutaneous anesthesia.
abstract: The effect of cutaneous analgesia on delayed type hypersensitivity (DTH) reactions as challenged by injections in the skin was assessed by comparing a lidocaine/prilocaine mixture with placebo. Application of 5 g of the mixture 90 min before testing significantly (p less than 0.001) reduced pain but did not influence the DH-reactions as read after 48 hours. Based on these findings, DTH to several antigens were measured in 116 school children, aged 7-15 years. All the children were positive to either tetanus antigen, 7.5 Lf/ml (98% at 48 hours) or mumps test antigen (82%), while positivity to tuberculin 2 TU/ml and candida 1000 PNU/ml were only 11 and 62% respectively. Therefore, DTH tests in an adequately immunized population of children can be limited to two antigens. Application of cutaneous analgesia is recommended as a routine procedure in DTH testing in young children.
authors.affiliation: Department of Pediatrics, University Hospital, Linköping, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Björkstén
authors.forename: B
authors.initials: B
authors.lastname: Jung
authors.forename: E B
authors.initials: EB
authors.lastname: Tågsjö
authors.forename: O
authors.initials: O
authors.lastname: Groth
mesh_terms: D000293:Adolescent; D000772:Anesthesia, Local; D000941:Antigens / Q000008:administration & dosage; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis*; D007271:Injections, Intradermal / Q000009:adverse effects; D008012:Lidocaine / Q000008:administration & dosage; D010146:Pain / Q000517:prevention & control*; D011318:Prilocaine / Q000008:administration & dosage
chemical_list: D000941:Antigens; D011318:Prilocaine; D008012:Lidocaine