title: Ontogeny of ovine lymphocytes. III. An immunohistological study on the development of T lymphocytes in sheep fetal lymph nodes.
abstract: The development of T lymphocytes in ovine fetal lymph nodes was studied immunohistologically using a panel of monoclonal antibodies. T lymphocyte subsets appeared within the ovine fetal lymph node in a specific sequence. SBU-T1- and SBU-T8-positive lymphocytes were seen at Day 47 of gestation. LCA, sIg, MHC I, MHC II, SBU-T6 and 46.66 antigens were also seen within the lymph node at this time. The first SBU-T4-positive cells were seen within the fetal lymph node at Day 50 of gestation, along with the first 20.96-, 25.69- and 38.38-positive cells. SBU-T19 lymphocytes appeared later in gestation, being present in fetal lymph nodes from Day 69 of gestation. The appearance and distribution of T and B cells in the developing lymph nodes of the ovine fetus is described and compared with the ontogeny of lymphocytes in the fetal thymus and spleen.
authors.affiliation: Department of Veterinary Preclinical Sciences, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: J F
authors.initials: JF
authors.lastname: Maddox
authors.forename: C R
authors.initials: CR
authors.lastname: Mackay
authors.forename: M R
authors.initials: MR
authors.lastname: Brandon
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002454:Cell Differentiation; D005865:Gestational Age; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000196:embryology* / Q000276:immunology; D012540:Scapula; D012756:Sheep / Q000196:embryology* / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology