title: Holoprosencephaly and related midline cerebral anomalies: a review.
abstract: We propose a simple pathogenetic mechanism that reduces a bewildering variety of central nervous system malformations to a manageable group sharing defects of midline prosencephalic growth. It is neither new nor innovative, but attempts to summarize many pathologic entities within a concept that accounts for known embryologic events and the sequence and timing of those events. We propose midline prosencephalic dysgenesis as a category of malformations including aprosencephaly, holoprosencephaly, septo-optic dysplasia, and agenesis of the corpus callosum.
authors.forename: R W
authors.initials: RW
authors.lastname: Leech
authors.forename: R M
authors.initials: RM
authors.lastname: Shuman
mesh_terms: D000015:Abnormalities, Multiple / Q000145:classification; D001921:Brain / Q000002:abnormalities* / Q000196:embryology; D002490:Central Nervous System / Q000002:abnormalities; D006801:Humans; D007231:Infant, Newborn