title: [Characteristics of intrarenal ampicillin distribution in chronic pyelonephritis in children].
abstract: Pharmacokinetics and characteristic features of ampicillin kidney distribution were studied in 21 children with chronic pyelonephritis without signs of renal insufficiency who had undergone urological operations. It was found possible to provide the antibiotic concentrations efficient against ampicillin sensitive and partially middle sensitive microorganisms in the renal parenchyma, pelvis wall, ureterocele, megaureter and urinary bladder. Ampicillin concentrations in tissues of the urinary system were shown to correspond to a higher extent to the concentrations attained in blood than those in urine.
authors.forename: V P
authors.initials: VP
authors.lastname: Iakovlev
authors.forename: L Z
authors.initials: LZ
authors.lastname: Skala
authors.forename: A G
authors.initials: AG
authors.lastname: Nekhorosheva
authors.forename: L A
authors.initials: LA
authors.lastname: Shabalova
authors.forename: I N
authors.initials: IN
authors.lastname: Borisov
mesh_terms: D000667:Ampicillin / Q000032:analysis / Q000493:pharmacokinetics*; D001681:Biological Assay; D002648:Child; D002908:Chronic Disease; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D009176:Mycoplasma mycoides / Q000378:metabolism; D011704:Pyelonephritis / Q000378:metabolism*; D014018:Tissue Distribution; D014551:Urinary Tract / Q000002:abnormalities / Q000378:metabolism
chemical_list: D000667:Ampicillin
vernacular_title: Osobennosti vnutripochechnogo raspredeleniia ampitsillina pri khronicheskom pielonefrite u deteĭ.