Improved exercise performance of hypertensive patients treated with guanfacine (Estulic Sandoz).
Guanfacine (trade name Estulic Sandoz), has turned out to be a very effective antihypertensive drug. During follow-up of 20 men with a hypertensive response to exercise, and with blood pressure values reaching or exceeding 230/120 mmHg, administration of 1-2 mg of the drug daily led to a decrease in heart rate and blood pressure. At the same time, patients' performance during exercise increased considerably, from 705 W prior to guanfacine administration, to 1.128 W after three-week therapy. Of the biochemical parameters monitored, a statistically significant decrease was observed in the levels of cholesterol, triglycerides and non-esterified fatty acids. There was an insignificant decrease in glycaemia.
Bazika
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Laboratory of Angiology, Charles University Faculty of General Medicine, Prague, Czechoslovakia.
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D005080:Exercise Test; D016316:Guanfacine; D006146:Guanidines / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D010648:Phenylacetates / Q000627:therapeutic use*; D012307:Risk Factors
D000959:Antihypertensive Agents; D006146:Guanidines; D010648:Phenylacetates; D016316:Guanfacine