Relationship between platelet cytosolic free calcium concentration and plasma renin activity.
1. Plasma renin activity (PRA) and platelet cytosolic free calcium concentration ([Ca2+]i) were simultaneously determined in 18 untreated essential hypertensive subjects and 17 normotensive controls. A significant positive correlation was found between [Ca2+]i and PRA (slope = 42 nmol/l/ng/ml/h) in these 35 subjects. 2. Two determinations more than one week apart in nine subjects confirmed the parallel fluctuations of [Ca2+]i and PRA. A strict sodium restriction produced a progressive PRA elevation associated with a parallel rise in [Ca2+]i in one subject. 3. These results are consistent with the hypothesis that angiotensin II causes a concentration-dependent calcium mobilization.
Le Quan Sang
K H
KH
Laboratoire de Pharmacologie, INSERM U7, Faculté de Médecine Necker-Enfants Malades, Paris, France.
Elghozi
J L
JL
Meyer
P
P
Devynck
M A
MA
D001792:Blood Platelets / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D003600:Cytosol / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D012083:Renin / Q000097:blood*
D012083:Renin; D002118:Calcium