[Effect of sodium selenite on the chromosomal aberration of V 79 cells induced in vitro by MNNG and MNU].
Effect of sodium selenite on chromosomal aberration of V 79 cells induced by MNNG and MNU was studied. Na2SeO3 alone, at the concentration of 10(-7)-10(-4) M, increased the incidence of chromosomal aberration. However, Na2SeO3 at 10(-7)-10(-5) M, having been preincubated with the cells for 4 hours, could reduce the number of cells with chromosomal aberration induced by MNNG. Na2SeO3 at 10(-7)-10(-4) M inhibited mutagenic activity of chromosomal aberration induced by MNU. The same inhibition was observed even sodium selenite was added to the medium simultaneously with this carcinogen. The results indicate that sodium selenite alone, at the concentration range used in this experiment, is an aberration-inducing agent. But when combined with the carcinogen, anti-cancer effect is obtained.
Chen
Q G
QG
Gao
F Z
FZ
Ke
Y
Y
Hu
G G
GG
Liu
X
X
Liu
J
J
Luo
X M
XM
D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D005347:Fibroblasts; D008168:Lung / Q000166:cytology; D008769:Methylnitronitrosoguanidine; D008770:Methylnitrosourea; D064586:Selenic Acid; D012643:Selenium / Q000494:pharmacology*; D018036:Selenium Compounds
D018036:Selenium Compounds; D008769:Methylnitronitrosoguanidine; D008770:Methylnitrosourea; D012643:Selenium; D064586:Selenic Acid