Reversal of renovascular hypertension: role of the renal medulla.
The fall in blood pressure, which occurs when renovascular hypertension is corrected surgically, offers a means of elucidating the factors responsible for blood pressure control. When Goldblatt two-kidney, one-clip hypertension in the rat is reversed by unclipping the renal artery, or by removal of the ischaemic kidney, restoration of normal blood pressure is due to a fall in peripheral resistance. This is associated with sodium retention and cannot be modified by inhibition of the renin-angiotensin system. The fall is, however, partially inhibited by chemical removal of the renal medulla by means of 2-bromo-ethylamine hydrobromide. When normal rats are chemically medullectomized, moderate hypertension is produced, which cannot be attributed to the renin-angiotensin system or sodium retention. It is concluded that a renomedullary vasodepressor system is ablated by chemical medullectomy: further, this system plays a role in the surgical correction of Goldblatt hypertension.
Swales
J D
JD
Department of Medicine, University of Leicester, U.K.
Bing
R F
RF
Edmunds
M E
ME
Russell
G I
GI
Thurston
H
H
D000818:Animals; D001794:Blood Pressure; D006339:Heart Rate; D006978:Hypertension, Renovascular / Q000503:physiopathology* / Q000628:therapy; D007679:Kidney Medulla / Q000503:physiopathology*; D009392:Nephrectomy; D051381:Rats; D012079:Renal Circulation; D012083:Renin / Q000097:blood; D014655:Vascular Resistance
D012083:Renin