Dietary sodium deprivation raises blood pressure in the rat but does not produce irreversible hyperaldosteronism.
It is reported that dietary deprivation of sodium in young rats produces changes of sodium balance and aldosterone excretion which persist when normal sodium intake is restored. To test this further, sodium intake was reduced 10-fold in rats. In the first experiment sodium intake was reduced for 5 weeks in rats aged 3 weeks. Systolic blood pressure, heart rate and plasma renin concentration increased and growth rate was reduced. Sodium intake was then increased for 10 weeks. Blood pressure, heart rate and plasma renin concentration fell and growth rate increased but body weight did not regain control values. As compared with controls, plasma concentrations of aldosterone and corticosterone did not increase after the 10-week period. Thus, sodium depletion did not produce an irreversible change in aldosterone but it did raise arterial pressure. Further experiments confirmed the pressor effect in young and adult rats. Blood pressure was measured in the tail in these experiments but the increase in pressure was not a technical artifact as measurements made in the tail correlated well with measurements made simultaneously by intra-arterial catheter. Catheters were inserted under general anaesthetic for this comparison of pressure and rats previously deprived of sodium showed a significantly higher mortality rate due to the anaesthesia and surgery involved. Thus, a 10-fold reduction of dietary sodium raises blood pressure in young and adult rats and it may increase mortality from a minor surgical procedure. It does not produce irreversible changes in aldosterone.
Webb
D J
DJ
MRC Blood Pressure Unit, Western Infirmary, Glasgow, Scotland, UK.
Clark
S A
SA
Brown
W B
WB
Fraser
R
R
Lever
A F
AF
Murray
G D
GD
Robertson
J I
JI
D000450:Aldosterone / Q000097:blood; D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D003345:Corticosterone / Q000097:blood; D006339:Heart Rate; D006929:Hyperaldosteronism / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D012964:Sodium / Q000172:deficiency*; D012982:Sodium, Dietary
D012982:Sodium, Dietary; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D003345:Corticosterone