title: Trial of a cysteine proteinase inhibitor, EST, in experimental chloroquine myopathy in rats.
abstract: The administration of 50 mg/kg/day of chloroquine to rats for 8 weeks produced the chloroquine myopathy characterized by autophagic vacuole formation and increases in lysosomal enzymes, especially cathepsins B & L. Coadministration of 10 mg/kg/day of a potent cysteine proteinase inhibitor, EST, and chloroquine prevented the induction of the chloroquine myopathy. Rats already suffering from the chloroquine myopathy were treated with 10 mg/kg/day of EST together with chloroquine injections for 5 weeks and also recovered remarkably from the myopathy. Thus, EST may be beneficial for myopathies associated with autophagic vacuoles.
authors.forename: H
authors.initials: H
authors.lastname: Sugita
authors.forename: I
authors.initials: I
authors.lastname: Higuchi
authors.forename: M
authors.initials: M
authors.lastname: Sano
authors.forename: S
authors.initials: S
authors.lastname: Ishiura
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000037:antagonists & inhibitors; D003546:Cysteine Endopeptidases; D010450:Endopeptidases; D007930:Leucine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D009132:Muscles / Q000201:enzymology / Q000473:pathology; D009135:Muscular Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D009929:Organ Size; D011480:Protease Inhibitors; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011480:Protease Inhibitors; D002738:Chloroquine; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; D007930:Leucine; C108192:aloxistatin