title: Multiple cerebral metastases: detectability with Gd-DTPA-enhanced MR imaging.
abstract: Sixteen patients with suspected cerebral metastases were studied with magnetic resonance (MR) imaging before and after the intravenous administration of 0.1 mmol/kg of gadolinium diethylenetriaminepenta-acetic acid. The images were interpreted blindly by two neuroradiologists; all clinical, radiologic (computed tomographic and MR imaging), and pathologic data were reviewed to arrive at a final "best diagnosis," which was then compared with the prior blinded interpretations. Of seven patients found to have multiple metastases, six (86%) had at least one tumor nodule depicted by postinfusion MR imaging that was missed by one or both observers on review of preinfusion images alone. Lesions missed on preinfusion studies were usually small nodules hidden by or not detected next to regions of high-signal edema thought to be related to the adjacent tumor nodule. The authors believe that contrast enhancement improves detection of metastatic foci with MR imaging and that the findings indicate broader implications for the detection of multiple lesions from other causes.
authors.affiliation: Department of Diagnostic Radiology, Northwestern University Medical School, Northwestern Memorial Hospital, Chicago, IL 60611.
authors.forename: E J
authors.initials: EJ
authors.lastname: Russell
authors.forename: G K
authors.initials: GK
authors.lastname: Geremia
authors.forename: C E
authors.initials: CE
authors.lastname: Johnson
authors.forename: M S
authors.initials: MS
authors.lastname: Huckman
authors.forename: R G
authors.initials: RG
authors.lastname: Ramsey
authors.forename: J
authors.initials: J
authors.lastname: Washburn-Bleck
authors.forename: D A
authors.initials: DA
authors.lastname: Turner
authors.forename: M
authors.initials: M
authors.lastname: Norusis
mesh_terms: D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005188:False Negative Reactions; D005189:False Positive Reactions; D005682:Gadolinium / Q000009:adverse effects; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009942:Organometallic Compounds / Q000009:adverse effects; D004369:Pentetic Acid / Q000009:adverse effects; D013997:Time Factors
chemical_list: D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA