title: Third-trimester biparietal diameter as a predictor of fetal lung maturity.
abstract: The major fetal risk associated with elective delivery is unexpected fetal lung immaturity and the development of hyaline membrane disease soon after birth. Prior to elective vaginal or abdominal delivery it has become standard obstetric practice to predict fetal lung maturity by the analysis of amniotic fluid obtained by amniocentesis or vaginal pool sample following preterm rupture of membranes. A correlation between third-trimester fetal biparietal diameter and the lecithin/sphingomyelin (L/S) ratio has been established by several investigators. In order to determine if a threshold BPD could be consistently correlated with fetal lung maturity, we retrospectively examined the hospital and laboratory records of a group of 115 nondiabetic parturients in whom BPD measurements and amniotic fluid analysis for L/S ratio had been performed for various clinical indications. A threshold BPD of greater than or equal to 9.2 cm in all parturients who underwent elective repeat cesarean delivery was associated with no hyaline membrane disease (HMD). Two of the three neonates who developed HMD had mature L/S ratios but were products of pregnancies complicated by third-trimester hemorrhage. A review of our present data suggests that about one-third of clinically-indicated amniocenteses in the absence of maternal diabetes or third-trimester hemorrhage could potentially be avoided without adverse neonatal impact. Possible therapeutic application of this finding requires further prospective study.
authors.forename: W A
authors.initials: WA
authors.lastname: Slocum
authors.forename: J N
authors.initials: JN
authors.lastname: Martin
authors.forename: R W
authors.initials: RW
authors.lastname: Martin
authors.forename: N S
authors.initials: NS
authors.lastname: Whitworth
authors.forename: J C
authors.initials: JC
authors.lastname: Morrison
mesh_terms: D000653:Amniotic Fluid / Q000032:analysis; D002508:Cephalometry / Q000379:methods; D005260:Female; D005325:Fetal Organ Maturity; D006801:Humans; D006819:Hyaline Membrane Disease / Q000175:diagnosis; D007231:Infant, Newborn; D008168:Lung / Q000196:embryology*; D008297:Male; D010294:Parietal Bone / Q000196:embryology*; D010713:Phosphatidylcholines / Q000032:analysis; D011237:Predictive Value of Tests; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D013109:Sphingomyelins / Q000032:analysis; D014463:Ultrasonography
chemical_list: D010713:Phosphatidylcholines; D013109:Sphingomyelins