title: Mutagenicity testing of some medicinal herbs.
abstract: Extracts of four brands of a Pakistani local medicine called naswar and six indigenous herbs commonly used as medicine in children were tested for their ability to induce mutations to prototrophy in Salmonella typhimurium tester strains TA98, TA100, TA1535, and TA1537. Petroleum ether extracts of one brand of naswar, namely green naswar of Peshawar, exhibited mutagenicity in all of the four tester strains. Organic extracts of three herbs, Saussurea lappa, Swertia chiraita, and Skimmia laureola, exhibited mutagenic activity in tester strain TA98. Green naswar of Bannu, grey naswar, red naswar, and the remaining three herbs, namely, Acorous calamus, Azadarachta indica, and Zanthozylum alatum, exhibited no mutagenic activity under the present experimental conditions. The abilities of green naswar of Peshawar and Saussurea lappa to induce mutations was shown to be related to the presence of cyclic aromatic compounds with molecular formulas C34 H44 O9 and C15 H18 O2, respectively. The experimental data are discussed as they relate to the potential hazards of such naturally occurring compounds and to synthetic compounds in excessive and uncontrolled use by the general public in villages in Pakistan.
authors.affiliation: Centre for Advanced Molecular Biology, University of the Punjab, Lahore, Pakistan.
authors.forename: S
authors.initials: S
authors.lastname: Riazuddin
authors.forename: M M
authors.initials: MM
authors.lastname: Malik
authors.forename: A
authors.initials: A
authors.lastname: Nasim
mesh_terms: D000818:Animals; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D010154:Pakistan; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000032:analysis*; D010947:Plants, Toxic; D011083:Polycyclic Compounds / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*; D014026:Nicotiana / Q000032:analysis
chemical_list: D010936:Plant Extracts; D011083:Polycyclic Compounds