title: Cytoplasmic polyhedrosis viruses in Phlebotomus papatasi inhibit development of Leishmania major.
abstract: Cytoplasmic polyhedrosis viruses (CPV's) were observed in wild-caught and laboratory-reared Phlebotomus papatasi. Chronic CPV pathology of the midgut, characterized by structural aberrations in the epithelium and the peritrophic membrane, interfered with blood digestion and rendered the sand flies refractory to Leishmania major infections. Rates of natural and artificial L. major infections were inversely correlated to the incidence of CPV infections. The interaction between viruses and protozoan parasites in an insect host is of basic biological interest and in this case may be of significance in the epidemiology of cutaneous leishmaniasis.
authors.forename: A
authors.initials: A
authors.lastname: Warburg
authors.forename: K
authors.initials: K
authors.lastname: Ostrovska
mesh_terms: D000818:Animals; D000898:Antibiosis; D003593:Cytoplasm / Q000382:microbiology; D005260:Female; D007304:Insect Viruses / Q000502:physiology*; D007422:Intestines / Q000382:microbiology / Q000648:ultrastructure; D007895:Leishmania tropica / Q000254:growth & development*; D010691:Phlebotomus / Q000382:microbiology* / Q000469:parasitology