The spectrum and significance of autoantibodies reacting with the thyrotropin receptor.
Autoantibodies that occur in autoimmune thyroid disease and that interact with the TSH receptor are reviewed. Current limited understanding of the nature of the TSH receptor is detailed, and available assays for the different types of antibodies are described. The incidence, clinical significance, and interactions of the various antibodies are summarized.
Zakarija
M
M
Department of Medicine, University of Miami School of Medicine, Florida.
McKenzie
J M
JM
D001323:Autoantibodies / Q000276:immunology*; D006111:Graves Disease / Q000235:genetics / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008135:Long-Acting Thyroid Stimulator / Q000276:immunology; D011989:Receptors, Thyrotropin / Q000276:immunology*; D013959:Thyroid Diseases / Q000276:immunology
D001323:Autoantibodies; D007074:Immunoglobulin G; D011989:Receptors, Thyrotropin; D008135:Long-Acting Thyroid Stimulator