Molecular structure and properties of fos-oncogene.
Finkel, Biskis and Jinkins murine osteosarcoma virus is a retrovirus that induces bone tumors in mice. The cellular homologue of this virus, c-fos, has been found in normal human and murine cells. This protooncogene is activated during several cell steps: is rapidly induced in cells stimulated to growth and to differentiate; often its induction precedes induction by other protooncogenes. The gene product is a phospho-nucleoprotein having a molecular weight of 55,000 d. The function of this protein is not known at the moment, opening a lot of interesting questions about the role of this protooncogene in normal cells.
Gandino
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Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD 21701-1013.
D000818:Animals; D001483:Base Sequence; D001859:Bone Neoplasms / Q000382:microbiology; D005814:Genes, Viral; D006801:Humans; D008970:Molecular Weight; D009857:Oncogenes; D012516:Osteosarcoma / Q000382:microbiology; D011519:Proto-Oncogenes; D012190:Retroviridae / Q000235:genetics