Bronchial asthma induced by mediators produced in vitro by sensitized lymphomonocytes. Protective effect of ketotifen.
A new procedure for the production in vitro of mediators of asthma is shortly described. This technique can be applied to the study of efficacy of anti-asthmatic agents. A double-blind study, which included 23 asthma patients was performed. Half of the patients were treated with Ketotifen 2 mg/day for 7 days, the other half with placebo. The patients were challenged with the cell cultures supernatants before and after the treatment period. The results obtained demonstrate a clear-cut protection of the patients treated with the active substance whereas the placebo group fail to do so.
Lech
B
B
Department of Medicine, Hopital Cantonal Universitaire, Geneva, Switzerland.
Girard
J P
JP
D000946:Antigens, Fungal / Q000276:immunology; D001249:Asthma / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D002176:Candida albicans; D002478:Cells, Cultured; D004311:Double-Blind Method; D004341:Drug Evaluation; D005541:Forced Expiratory Volume; D006801:Humans; D007665:Ketotifen / Q000627:therapeutic use*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008222:Lymphokines / Q000378:metabolism; D011897:Random Allocation
D000946:Antigens, Fungal; D008222:Lymphokines; D007665:Ketotifen