title: Interaction of ascorbate and alpha-tocopherol.
abstract: Vitamins C and E function as water-soluble and lipid-soluble chain-breaking antioxidants, respectively, and protect lipids, proteins, and membranes from oxidative damage. Vitamin C scavenges oxygen radicals in the aqueous phase, whereas vitamin E scavenges oxygen radicals within the membranes. Vitamin C regenerates vitamin E by reducing vitamin E radicals formed when vitamin E scavenges the oxygen radicals. This interaction between vitamin C and vitamin E radicals can take place not only in homogeneous solutions but also in liposomal membrane systems where vitamins C and E reside separately outside and within the membranes respectively, and vitamin C can act as a synergist.
authors.forename: E
authors.initials: E
authors.lastname: Niki
mesh_terms: D000975:Antioxidants; D001205:Ascorbic Acid / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004357:Drug Synergism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005520:Food Preservatives; D005609:Free Radicals; D008054:Lipid Peroxides / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D005231:Fatty Acids, Unsaturated; D005520:Food Preservatives; D005609:Free Radicals; D008054:Lipid Peroxides; D014810:Vitamin E; D001205:Ascorbic Acid; D010100:Oxygen