Cytochemical localization of NADH and NADPH oxidases during interaction of Trypanosoma cruzi with activated macrophages.
NADH- or NADPH-oxidase activity was cytochemically detected at the ultrastructural level during the process of interaction between Trypanosoma cruzi and activated mouse peritoneal macrophages. The reaction product, indicative of enzyme activity, was found in the portion of the plasma membrane of the macrophages to which the parasites attached. It was also found in the membrane which surrounds endocytic vacuoles containing ingested parasites.
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D000818:Animals; D006790:Host-Parasite Interactions; D008262:Macrophage Activation; D008264:Macrophages / Q000201:enzymology / Q000469:parasitology* / Q000648:ultrastructure; D051379:Mice; D008854:Microscopy, Electron; D009097:Multienzyme Complexes / Q000032:analysis*; D009247:NADH, NADPH Oxidoreductases / Q000032:analysis*; D019255:NADPH Oxidases; D014349:Trypanosoma cruzi / Q000502:physiology* / Q000648:ultrastructure
D009097:Multienzyme Complexes; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases