[In vitro study of the transplacental passage of chloroquine sulfate].
The authors, by performing in vitro perfusion on six human placentas, have studied the passage of chloroquine sulphate into the placenta. The drug levels were recorded by high performance liquid chromatography (HPLC). The placental perfusions lasted one hour and drug passage into placental tissue was low (14.21%) which seems to be due to the high degree of fixation of chloroquine on placental tissue.
Leng
J J
JJ
Maternité A, Hôpital Pellegrin, Bordeaux, France.
Mbanzulu
P N
PN
Akbaraly
J P
JP
Albin
H
H
Guibert
S
S
Gravier
J
J
Demotes-Mainard
F
F
D002738:Chloroquine / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D013997:Time Factors
D002738:Chloroquine
Etude in vitro du passage trans-placentaire du sulfate de chloroquine.