Endogenous production of infectious Inoue-Melnick virus in a human meningioma cell line.
We investigated continuous production of Inoue-Melnick virus (IMV) in the MG-1 cell line, established from human meningioma. The infectious virus, identified as a type 1 virus, was mostly recovered extracellularly. Assay of MG-1 cells as infective centers indicated that most of the cells were capable of producing infectious virus. By immunofluorescence, more than 90% of the cells were found to have IMV-associated cytoplasmic antigen(s) (IMCA).
Nishibe
Y
Y
Institute for Virus Research, Kyoto University, Japan.
Inoue
Y K
YK
Hollinshead
A C
AC
D002460:Cell Line; D005455:Fluorescent Antibody Technique; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008577:Meningeal Neoplasms; D008579:Meningioma; D009500:Neutralization Tests; D014780:Viruses / Q000254:growth & development* / Q000302:isolation & purification