[Anti-inflammatory properties of asperase--a new enzymatic substance with proteolytic action].
The anti-inflammatory effect of asperase was shown on models of protein, aerosil and formalin edemas. The effect was the same as that of trypsin and was more pronounced as compared with that of chymotrypsin. Intramuscular administration of asperase stimulated the growth of granulation tissue as well. Inhibition of the enzyme activity with respect to a high molecular protein (casein) had no influence on the manifestation of its anti-inflammatory effect.
Maslov
N F
NF
Liubetskaia
Zh A
ZhA
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002918:Chymotrypsin / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006097:Granulation Tissue / Q000187:drug effects; D051379:Mice; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D051381:Rats; D014357:Trypsin / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D010447:Peptide Hydrolases; C036595:asperase; D002918:Chymotrypsin; D014357:Trypsin
Protivovospalitel'nye svoĭstva asperazy--novogoo fermentnogo veshchestva proteoliticheskogo deĭstviia.