Development of Ly-1+ B cells in immunodeficient CBA/N mice.
Spleen cells from CBA/N mice developing a systemic autoimmune disease after daily injection of CsA during an autologous bone marrow reconstitution were transferred into unmanipulated syngeneic recipients. Adoptive transfer allowed the development of Ly-1+ B cells, which shared Mac-1 differentiation antigen expression with the myelomonocytic lineage. Interestingly, expansion of formerly absent Ly-1+ B cells was paralleled by a severe reduction in common, Ly-1-, B cell development in the recipient. We conclude that precursors for Ly-1+ B lineage do exist in CBA/N mice.
de la Hera
A
A
Marcos
M A
MA
Toribio
M L
ML
Marquez
C
C
Gaspar
M L
ML
Martinez
C
C
D000818:Animals; D000950:Antigens, Ly / Q000276:immunology*; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000473:pathology; D003524:Cyclosporins; D006412:Hematopoietic Stem Cells / Q000473:pathology; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000473:pathology / Q000637:transplantation; D014916:Whole-Body Irradiation
D000950:Antigens, Ly; D003524:Cyclosporins