Identification of the gene for the yeast ribonucleotide reductase small subunit and its inducibility by methyl methanesulfonate.
We have identified, cloned, and sequenced the gene for the small subunit of ribonucleotide diphosphate reductase of Saccharomyces cerevisiae. The protein and its transcript are induced about 10-fold by the alkylating agent methyl methanesulfonate, a result which suggests that the gene is induced by DNA damage.
Hurd
H K
HK
Section of Biochemistry, Molecular & Cell Biology, Cornell University, Ithaca, New York 14853.
Roberts
C W
CW
Roberts
J W
JW
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D003429:Cross Reactions; D004249:DNA Damage; D005786:Gene Expression Regulation / Q000187:drug effects*; D005796:Genes; D005800:Genes, Fungal; D008741:Methyl Methanesulfonate / Q000494:pharmacology*; D008969:Molecular Sequence Data; D011938:Rec A Recombinases / Q000235:genetics; D012264:Ribonucleotide Reductases / Q000235:genetics* / Q000276:immunology; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects
D008741:Methyl Methanesulfonate; D012264:Ribonucleotide Reductases; D011938:Rec A Recombinases