Knob antigen deposition in cerebral malaria.
Plasmodium falciparum-infected erythrocytes attach to the endothelial cells via electron-dense knobs and this attachment has been suggested as one of the contributing factors in the development of cerebral malaria. Monoclonal antibodies against an 80-95 Kd knob protein were prepared and applied to brain tissue from cerebral malaria patients. The deposition of the 80-95 Kd knob protein antibodies was observed in the basement membrane of cerebral capillaries by the peroxidase anti-peroxidase method. This result indicates involvement of knob protein deposition in the pathogenesis of cerebral malaria.
Igarashi
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Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106.
Oo
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Stanley
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Reese
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Aikawa
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D000328:Adult; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000953:Antigens, Protozoan / Q000302:isolation & purification*; D001485:Basement Membrane / Q000469:parasitology; D001927:Brain Diseases / Q000469:parasitology* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008288:Malaria / Q000276:immunology / Q000473:pathology*; D008297:Male; D010455:Peptides / Q000276:immunology; D010963:Plasmodium falciparum; D015800:Protozoan Proteins
D000911:Antibodies, Monoclonal; D000953:Antigens, Protozoan; D010455:Peptides; D015800:Protozoan Proteins; C042968:knob protein, Plasmodium falciparum