title: Renal magnesium wasting in two families with autosomal dominant inheritance.
abstract: Hypomagnesemia due to isolated renal magnesium loss was demonstrated in two unrelated families with autosomal dominant mode of inheritance. Magnesium infusions performed in two patients showed not only a reduced renal magnesium threshold but also a lowered renal tubular maximum for magnesium. All members of both families who presented with hypomagnesemia had also a lowered excretion of calcium in the urine, presumably as a consequence of increased reabsorption in Henle's loop.
authors.forename: W B
authors.initials: WB
authors.lastname: Geven
authors.forename: L A
authors.initials: LA
authors.lastname: Monnens
authors.forename: H L
authors.initials: HL
authors.lastname: Willems
authors.forename: W C
authors.initials: WC
authors.lastname: Buijs
authors.forename: B G
authors.initials: BG
authors.lastname: ter Haar
mesh_terms: D002118:Calcium / Q000097:blood / Q000652:urine; D002869:Chromosome Aberrations / Q000235:genetics* / Q000378:metabolism; D025063:Chromosome Disorders; D007668:Kidney / Q000378:metabolism*; D008274:Magnesium / Q000097:blood / Q000652:urine; D008275:Magnesium Deficiency / Q000150:complications / Q000235:genetics*; D010375:Pedigree; D012083:Renin / Q000097:blood; D012640:Seizures / Q000209:etiology
chemical_list: D012083:Renin; D008274:Magnesium; D002118:Calcium