title: Implantation of human keloid into athymic mice.
abstract: In the interest of developing an animal model for keloids, human keloid dermis was implanted in the subcutaneous tissues of athymic (nude) mice. Subsequent growth resulted in a lesion with histology similar to the original keloid. Fibroblasts were cultured from keloid dermis. When the fibroblasts alone were implanted in the subcutaneous tissues of nude mice, growth of a visible lesion was again produced. The fibroblasts had proliferated and deposited collagen in an abnormal fashion with the histology resembling the parent keloid. Further research could develop this into a reliable animal model to allow in vivo experimentation.
authors.affiliation: Division of Otolaryngology, Head and Neck Surgery, University of Missouri-Columbia.
authors.forename: S A
authors.initials: SA
authors.lastname: Estrem
authors.forename: M
authors.initials: M
authors.lastname: Domayer
authors.forename: J
authors.initials: J
authors.lastname: Bardach
authors.forename: A E
authors.initials: AE
authors.lastname: Cram
mesh_terms: D000328:Adult; D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D007627:Keloid / Q000473:pathology*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D016038:Skin Transplantation