title: Effects of cisapride on gastroparesis in patients with insulin-dependent diabetes mellitus. A double-blind controlled trial.
abstract: Fourteen insulin-dependent diabetics with symptoms and signs of delayed gastric emptying were treated with a new prokinetic agent, cisapride. In a placebo-controlled cross-over trial no significant differences from placebo was found regarding overall symptomatic effects and effects on gastric emptying of a mixed solid/liquid isotope marked test meal. Solid emptying was most markedly delayed in diabetics compared with healthy controls, but the emptying rate was not correlated to the severity of symptoms as observed for liquid emptying. During active treatment with cisapride the amelioration of symptoms was correlated to increased emptying rates assessed by combined measure of liquid/solid gastric emptying.
authors.affiliation: Department of Medical Gastroenterology, Odense University Hospital, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Havelund
authors.forename: E
authors.initials: E
authors.lastname: Oster-Jørgensen
authors.forename: O
authors.initials: O
authors.lastname: Eshøj
authors.forename: M L
authors.initials: ML
authors.lastname: Larsen
authors.forename: K
authors.initials: K
authors.lastname: Lauritsen
mesh_terms: D020117:Cisapride; D002986:Clinical Trials as Topic; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D004311:Double-Blind Method; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D010880:Piperidines / Q000494:pharmacology*
chemical_list: D010880:Piperidines; D020117:Cisapride