title: [Neurotraumatology and post-traumatic epilepsy. Prevention, treatment and long-term follow-up. Barbexaclone + phenobarbital (maliasin) versus diphenylhydantoin, phenobarbital, primidone, carbamazepine].
abstract: A report is presented on 58 patients (46 males, 12 females) all suffering from post-traumatic epilepsy (PTE) and followed up for a minimum of 1 year to maximum of 23 years after the injury (mean 6.3 years). The type and site of the head injury, the nature of the brain lesions, the time elapsing before the first critical manifestation, the clinical character of the epileptic attacks, EEG, cerebral CAT and RMN data were performed are given for all patients. The therapeutic and prophylactic strategies adopted are then described in detail with particular emphasis on the use of diphenylhydantoin (DPH) and barbexaclone. The latter drug, used for the last 3 years was found to be particularly useful in the treatment of patients suffering from a post-traumatic psycho-organic syndrome in addition to the PTE.
authors.affiliation: Università di Bologna, Istituto di Clinica Neurologica.
authors.forename: A
authors.initials: A
authors.lastname: Borromei
authors.forename: R
authors.initials: R
authors.lastname: Caramelli
authors.forename: G
authors.initials: G
authors.lastname: Cipriani
authors.forename: L C
authors.initials: LC
authors.lastname: Giancola
authors.forename: L
authors.initials: L
authors.lastname: Guerra
authors.forename: A
authors.initials: A
authors.lastname: Lozito
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D001930:Brain Injuries / Q000150:complications*; D002220:Carbamazepine / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D010672:Phenytoin / Q000627:therapeutic use*; D011324:Primidone / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D011324:Primidone; C011019:barbexaclone; D002220:Carbamazepine; D010672:Phenytoin; D010634:Phenobarbital
vernacular_title: Neurotraumatologia ed epilessia post-traumatica. Profilassi, trattamento e follow-up a lunga distanza. Barbesaclone + PB ("maliasin") vs difenilidantoina, phenobarbital, primidone, carbamazepina.