title: Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes.
abstract: A number of rat monoclonal antibodies of the IgG2b subclass have been used to deplete mice of T lymphocyte subsets. It has been possible to produce long-term depletion where antibodies are administered to mice thymectomized in their adult life, or short-term depletion in euthymic animals. It is therefore feasible to ablate a T lymphocyte subpopulation at any stage in the course of an immune response and to examine in detail the role of a particular subset in the induction or effector phases of that response. We have used such ablative procedures to define the T cell subsets which participate in graft rejection, graft-versus-host disease, antigenic competition and antiviral and anti-self immunity and have attempted to exploit such knowledge to establish immunological tolerance in an adult animal.
authors.affiliation: Department of Pathology, University of Cambridge, Cambridge, UK.
authors.forename: H
authors.initials: H
authors.lastname: Waldmann
authors.forename: S
authors.initials: S
authors.lastname: Cobbold
authors.forename: S
authors.initials: S
authors.lastname: Qin
authors.forename: R
authors.initials: R
authors.lastname: Benjamin
authors.forename: T
authors.initials: T
authors.lastname: Nash
authors.forename: J
authors.initials: J
authors.lastname: Welsh
authors.forename: G
authors.initials: G
authors.lastname: Tarnesby
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D000950:Antigens, Ly / Q000276:immunology*; D006084:Graft Rejection; D006086:Graft vs Host Disease / Q000276:immunology; D008212:Lymphocyte Depletion; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000950:Antigens, Ly