title: [Ultrastructural features of pancreatic islet cells during prolonged glucose administration].
abstract: The time course of ultrastructural changes in pancreatic islet cells was studied in experiments on albino male rats in prolonged administration of glucose at a dose of 15 g per 1 kg of body mass 3 times daily. Changes in the ultrastructures of beta-cells revealed in the first 10 days, indicated their functional tension. Later on (in 15-30 days) an increase in the level of blood serum immunoreactive insulin manifested itself in hypertrophy and hyperplasia of the intracellular structures of beta-insulocytes. An increase in the synthesis and excretion of insulin by beta-cells promoted the utilization of administered glucose manifesting itself in hypoglycemia on an empty stomach and a more intensive increment of the body mass of experimental animals. A relative volume of pancreatic islets over a studied period did not significantly change as compared with the control one.
authors.forename: B A
authors.initials: BA
authors.lastname: Khidoiatov
authors.forename: T A
authors.initials: TA
authors.lastname: Tomina
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology*; D006965:Hyperplasia; D006984:Hypertrophy; D007328:Insulin / Q000378:metabolism; D007515:Islets of Langerhans / Q000378:metabolism / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D009940:Organoids / Q000648:ultrastructure; D051381:Rats; D013997:Time Factors
chemical_list: D007328:Insulin; D005947:Glucose
vernacular_title: Ul'trastrukturnye osobennosti kletok pankreaticheskikh ostrovkov pri dlitel'nom vvedeniia gliukozy.