[Nuclear receptors in estrogen receptor negative tumors with progesterone receptors].
The nuclear estrogen receptors ERn were determined in 12 carcinomas whose cytoplasm contained progesterone receptors PRc but no estrogen receptors ERc. ERn were found in 9 of the tumors. Their concentration correlated to those of PRc and reached a mean of only 20% of the ERn concentrations found in ERc+/PRc + carcinomas. These results suggest that in carcinomas of the ERc-/PRc+-type, originally present cytoplasmic estrogen receptors induce the synthesis of progesterone receptors in a concentration corresponding to that of the nuclear receptors, following translocation by endogenous estradiol in the nucleus.
Geyer
H
H
Braun
A
A
D001943:Breast Neoplasms / Q000032:analysis; D002467:Cell Nucleus / Q000032:analysis*; D003593:Cytoplasm / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D004958:Estradiol / Q000032:analysis; D005260:Female; D005833:Genital Neoplasms, Female / Q000032:analysis*; D006801:Humans; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D014594:Uterine Neoplasms / Q000032:analysis
D004273:DNA, Neoplasm; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D004958:Estradiol
Kernrezeptoren in Ostrogenrezeptor-negativen tumoren mit Progesteronrezeptoren.