title: Insulin secretion to glucose infusion in gestational diabetes subjects with differing DNA polymorphisms flanking the insulin gene.
abstract: Glucose-stimulated insulin secretion was assessed in relation to the DNA polymorphism flanking the insulin gene in 16 women who had had gestational diabetes. When not pregnant they were studied by a Constant Glucose Infusion for 1 hr with Model Assessment (CIGMA). The patients with either heterozygous 1/3 alleles or homozygous 1/1 or 3/3 alleles in the 5' flanking region of the insulin gene had similar plasma insulin and C-peptide concentrations and similar estimates of beta-cell function. This suggests that the large DNA insert (Class 3 allele) near the insulin gene does not directly affect insulin secretion. The association of polymorphisms with Type 2 diabetes may be due to linkage disequilibrium with other disease-related alleles.
authors.forename: A
authors.initials: A
authors.lastname: Samanta
authors.forename: A C
authors.initials: AC
authors.lastname: Burden
authors.forename: N I
authors.initials: NI
authors.lastname: Jowett
authors.forename: D J
authors.initials: DJ
authors.lastname: Galton
authors.forename: J P
authors.initials: JP
authors.lastname: Hosker
authors.forename: R C
authors.initials: RC
authors.lastname: Turner
mesh_terms: D000328:Adult; D000483:Alleles; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000235:genetics* / Q000378:metabolism; D000078790:Insulin Secretion; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000235:genetics* / Q000378:metabolism
chemical_list: D007328:Insulin; D005947:Glucose