Free drug monitoring.
The principles, technique of measurement, and clinical significance of free drugs are reviewed. Albumin, alpha-1-acid glycoprotein, and lipoprotein are the main drug-binding proteins in blood. Variations of the concentrations of these proteins owing to disease would result in changes in the free drug levels. These levels may be determined by equilibrium dialysis, ultrafiltration, and other techniques.
Chan
S
S
Gerson
B
B
D001798:Blood Proteins / Q000378:metabolism; D006801:Humans; D008991:Monitoring, Physiologic; D004364:Pharmaceutical Preparations / Q000097:blood*; D011485:Protein Binding
D001798:Blood Proteins; D004364:Pharmaceutical Preparations