title: Selective induction of a heat shock gene in fibre tracts and cerebellar neurons of the rabbit brain detected by in situ hybridization.
abstract: In situ hybridization reveals striking regional differences in the expression of constitutive and inducible heat shock genes in the rabbit brain. Fibre tracts throughout the brain show a dramatic induction of heat shock mRNA after hyperthermia, a pattern consistent with a strong glial response to heat shock. While neurons in the cerebellum exhibit a marked induction of heat shock mRNA, neurons of the hippocampus do not. Constitutive expression of a heat shock gene is observed in neuronal laminae of the hippocampus and cerebellum.
authors.affiliation: Department of Zoology, University of Toronto, West Hill, Ont., Canada.
authors.forename: G K
authors.initials: GK
authors.lastname: Sprang
authors.forename: I R
authors.initials: IR
authors.lastname: Brown
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000166:cytology / Q000502:physiology*; D005334:Fever / Q000235:genetics; D005786:Gene Expression Regulation; D005796:Genes; D005821:Genetic Techniques; D006360:Heat-Shock Proteins / Q000235:genetics*; D009412:Nerve Fibers / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011817:Rabbits
chemical_list: D006360:Heat-Shock Proteins