title: In vitro chloroquine-resistant falciparum malaria in Malabo, Equatorial Guinea: case reports.
abstract: For many years the chloroquine-resistant problem in Africa was circumscribed to East Africa, but in the last two years it has been spreading progressively to the West. We report here the two first cases of chloroquine-resistant falciparum malaria imported into Spain from Equatorial Guinea. Both cases show a parasitological grade III resistance in a W.H.O. in vitro macrotest. The clinical recovery with the alternative treatment (Fansidar) was satisfactory.
authors.affiliation: Centro Nacional de Microbiología, Virología e Immunología Sanitarias, Majadahonda, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Alvar
authors.forename: S
authors.initials: S
authors.lastname: Puente
authors.forename: J
authors.initials: J
authors.lastname: Blázquez
mesh_terms: D000293:Adolescent; D000354:Africa, Western; D000818:Animals; D002738:Chloroquine / Q000494:pharmacology / Q000627:therapeutic use*; D004351:Drug Resistance; D006169:Guinea-Bissau; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics; D013030:Spain
chemical_list: D002738:Chloroquine