Effect of sham-feeding on glucose tolerance and insulin secretion.
Glucose, 25 g, was infused iv with or without sham-feeding in seven normal males. Sham-feeding improved glucose tolerance, incremental area of blood glucose being 63% (P less than 0.05) of that during iv glucose without sham-feeding. The actual insulin secretion evaluated from the total area under the C-peptide and insulin curves did not differ during iv glucose with or without sham-feeding. These results suggest that the cephalic-vagal reflex improves glucose tolerance during iv glucose, independent of changes in beta-cell function.
Lorentzen
M
M
Madsbad
S
S
Kehlet
H
H
Tronier
B
B
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D004435:Eating; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010191:Pancreatic Polypeptide / Q000097:blood
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D010191:Pancreatic Polypeptide