Effect of insulin on the size of skeletal muscle fibers of fetal rhesus monkey.
Increased body weight of insulin-treated fetuses is largely attributed to increased muscle mass. Skeletal muscle from fetal rhesus monkeys was analyzed for differences in the sizes of muscle fibers from monkeys treated in utero with high or low doses of insulin and compared to control (non-insulin-treated) animals. The results indicate no significant difference among the various groups studied and suggest that hyperplasia, not hypertrophy, of skeletal muscle fibers is responsible for the observed increase in muscle mass.
Martins
E A
EA
Neave
C
C
Susa
J B
JB
Singer
D B
DB
D000818:Animals; D005333:Fetus / Q000033:anatomy & histology / Q000187:drug effects*; D007328:Insulin / Q000494:pharmacology*; D008253:Macaca mulatta; D009132:Muscles / Q000033:anatomy & histology / Q000187:drug effects*
D007328:Insulin