High sodium rehydration solutions in well-nourished outpatients.
We studied the safety and efficacy of high-sodium oral rehydration solution in the out-patient management of children with diarrhea, with or without dehydration. We studied 68 outpatients with acute diarrhea; 32% had mild-to-moderate dehydration; the rest were not dehydrated. They were treated at home for 24 h with either high-sodium (90 mmol/l) or low-sodium (30 mmol/l) solution. None of the patients given high-sodium solution became hypernatremic. Of those patients who were dehydrated, 55% did not take enough fluid at home to repair their dehydration. We conclude that patients must be closely supervised for the initial rehydration period, but that high-sodium rehydration solutions can be safely given to outpatients for up to 24 hours.
Herzog
L W
LW
Bithoney
W G
WG
Grand
R J
RJ
D000208:Acute Disease; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003967:Diarrhea / Q000097:blood / Q000628:therapy*; D003968:Diarrhea, Infantile / Q000097:blood / Q000628:therapy*; D005440:Fluid Therapy / Q000009:adverse effects; D006801:Humans; D007223:Infant; D011320:Primary Health Care