Bromocriptine-desipramine protocol in treatment of cocaine addiction.
Thirty-six male cocaine abusers, in withdrawal, were studied for 99 days in a double-blind design. Treatment with bromocriptine was significantly more effective than placebo in alleviating withdrawal symptoms. Adding desipramine to the bromocriptine regimen was significantly more effective than either placebo or bromocriptine alone. The authors hypothesize that these results support a model of dopamine depletion and receptor supersensitivity in cocaine withdrawal.
Giannini
A J
AJ
Northeastern Ohio Universities, College of Medicine, Youngstown.
Billett
W
W
D000328:Adult; D001971:Bromocriptine / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003042:Cocaine; D003891:Desipramine / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011897:Random Allocation; D019966:Substance-Related Disorders / Q000188:drug therapy* / Q000523:psychology; D013997:Time Factors
D001971:Bromocriptine; D003042:Cocaine; D003891:Desipramine