title: Activity of phenothiazines against medically important yeasts.
abstract: Two phenothiazine compounds, trifluoperazine and chlorpromazine, inhibited growth in vitro of the five most common pathogenic yeasts, with MICs ranging from 10 to 40 micrograms/ml. Daily intraperitoneal injections of trifluoperazine (4 to 7 mg/kg of body weight) increased the survival of mice experimentally infected with Candida albicans or Cryptococcus neoformans. The potential use of these drugs against fungal meningitis is discussed.
authors.forename: Y
authors.initials: Y
authors.lastname: Eilam
authors.forename: I
authors.initials: I
authors.lastname: Polacheck
authors.forename: G
authors.initials: G
authors.lastname: Ben-Gigi
authors.forename: D
authors.initials: D
authors.lastname: Chernichovsky
mesh_terms: D000818:Animals; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002177:Candidiasis / Q000188:drug therapy; D002746:Chlorpromazine / Q000494:pharmacology*; D003453:Cryptococcosis / Q000188:drug therapy; D003454:Cryptococcus / Q000187:drug effects*; D003455:Cryptococcus neoformans / Q000187:drug effects* / Q000254:growth & development; D005260:Female; D006801:Humans; D051379:Mice; D014268:Trifluoperazine / Q000494:pharmacology*
chemical_list: D014268:Trifluoperazine; D002746:Chlorpromazine