title: Facile preparation of purine and pyrimidine 2-deoxy-beta-D-ribonucleosides by biotransformation on encapsulated cells.
abstract: A preparative-scale synthesis of pyrimidine or purine 2'-deoxy-beta-D-ribonucleosides from a heterocyclic base and 2'-deoxyuridine proceeds by biotransformation reaction in the presence of thymine-dependent E. coli mutant cells encapsulated in alginate gel. The products are isolated by octadecyl-silica or ion-exchange chromatography.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Praha 6.
authors.forename: A
authors.initials: A
authors.lastname: Holý
authors.forename: I
authors.initials: I
authors.lastname: Votruba
mesh_terms: D001711:Biotransformation; D003853:Deoxyribonucleosides / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism*; D005782:Gels; D013941:Thymine / Q000378:metabolism
chemical_list: D003853:Deoxyribonucleosides; D005782:Gels; D013941:Thymine