Selective elevation of c-myc transcript levels in the liver of the aging Fischer-344 rat.
The expression of several proto-oncogenes involved in normal cell growth was examined as a function of age in male Fischer-344 rats aged 3, 6-9, 12 and 21-23 months. Northern blot analysis using RNA isolated from pooled livers or brains showed that the transcript levels of c-myc, but not c-sis or c-src-related genes, were markedly elevated in the liver with age. In contrast, there was no substantial change in transcript levels of any of these genes in aging brain. When c-myc expression was analyzed in livers from individual rats ranging in age from 4 to 22 months, a significant (p less than 0.01) 5-fold increase in c-myc transcript levels in relation to age was detected. The results indicate that expression of c-myc in rat liver is modulated during aging and more generally, that aging in rats is associated with organ-specific changes in the transcript levels of particular genes.
Matocha
M F
MF
Cosgrove
J W
JW
Atack
J R
JR
Rapoport
S I
SI
D000375:Aging; D000818:Animals; D001921:Brain / Q000502:physiology; D005786:Gene Expression Regulation; D008099:Liver / Q000502:physiology; D008297:Male; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011916:Rats, Inbred F344 / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*; D014158:Transcription, Genetic
D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger