[Treatment of post-traumatic and post-neurosurgical bacterial meningitis with ceftriaxone alone or in combination with fosfomycin].
From 1984 to 1986, 13 patients (10 adults, 3 children) with bacterial meningitis following neurosurgery or traumatism were given ceftriaxone alone 6 times at a dose of 40 mg/kg one IV injection per day, or in association 7 times with fosfomycin at a dose of 200 mg/kg/day, 3 IV perfusions every 4 h. The bacteriological diagnosis was confirmed in 9 cases (3 Staphylococcus aureus, 4 Streptococcus pneumoniae, 1 Klebsiella, 1 Peptococcus). In vitro neither synergy nor antagonism were observed between the two antimicrobial agents. The acute infections episode resolved in all patients except on who died with a negative CSF culture. One superinfection meningitis with Achromobacter was seen. CSF concentrations of ceftriaxone were assayed and found to be comparable with those reported by most authors. Tolerance was excellent for all our patients.
May
T
T
Département des Maladies Infectieuses et Tropicales, CHRU Nancy-Brabois, Vandoeuvre-Les-Nancy.
Weber
M
M
Gérard
A
A
Schmit
J L
JL
Voiriot
P
P
Czorny
A
A
Canton
P
P
Dureux
J B
JB
D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy*; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D004359:Drug Therapy, Combination; D005578:Fosfomycin / Q000008:administration & dosage*; D006801:Humans; D008581:Meningitis / Q000188:drug therapy* / Q000209:etiology; D009493:Neurosurgery / Q000009:adverse effects*; D011183:Postoperative Complications / Q000188:drug therapy*; D012887:Skull Fractures / Q000150:complications
D005578:Fosfomycin; D002443:Ceftriaxone
Traitement des méningites bactériennes post-traumatiques et post-neurochirurgicales par la ceftriaxone seule ou en association avec la fosfomycine.