Effect of antithyroid autoantibodies on pancreatic islet-cell function.
Insulin-dependent diabetes mellitus is frequently associated with organ-specific autoimmune diseases and/or high titers of organ-specific autoantibodies. The effects of thyroid autoantibodies on islet-cell function were examined in the present study. Islet cell surface antibody (ICSAb) was detected in sera from 6 of 40 patients with autoimmune thyroid disease (AITD) who were positive for thyroid microsomal autoantibodies (TMA). Furthermore, all of the ICSAb-positive patients had high TMA titers. In vitro study using isolated rat pancreatic islets revealed that TMA positive sera significantly suppressed glucose-induced insulin release. Only one of 19 (5%) AITD patients showed complement-dependent antibody-mediated cytotoxicity and only one of 6 AITD patients (17%) was positive for antibody-dependent cellular cytotoxicity. These results suggest that TMA has an effect on an antigen of the islet cell membrane in which insulin releasing mechanism might be involved.
Kitano
N
N
Taminato
T
T
Seno
M
M
Miyamoto
Y
Y
Seino
Y
Y
Matsukura
S
S
Imura
H
H
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D000954:Antigens, Surface / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D003165:Complement System Proteins / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology; D005069:Evaluation Studies as Topic; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000276:immunology* / Q000378:metabolism; D010179:Pancreas / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000276:immunology*
D000954:Antigens, Surface; D001323:Autoantibodies; D007328:Insulin; D003165:Complement System Proteins