The evolution of chemotherapy of lymphomas of adults.
Patients with advanced stages of Hodgkin's disease and diffuse large-cell lymphoma are curable with combination chemotherapy. The studies conducted at the National Cancer Institute over the past 20 years are reviewed along with pertinent studies conducted elsewhere. It is the author's contention that there is room for considerable improvement in results with existing therapy if greater attention is paid to dosing and less to trying to improve, by slight modifications, on treatments that should be regarded as a temporary stage in the development of standard lymphoma treatment.
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National Cancer Institute, Bethesda, Maryland 20205.
D000971:Antineoplastic Combined Chemotherapy Protocols; D003131:Combined Modality Therapy; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000532:radiotherapy