Evidence that protein kinase C is involved in regulating glucose transport in the adipocyte.
The role of protein kinase C in the mechanism of stimulation of glucose transport in rat adipocytes was investigated. Glucose transport was stimulated by dioleoylglycerol (DOG), tetradecanoyl phorbol acetate (TPA) and phospholipase C (PLC). Agents that inhibit protein kinase C (polymyxin B, gossypol and quercitin) also inhibited glucose transport that had been stimulated by DOG, TPA, PLC and insulin.
Christensen
R L
RL
Shade
D L
DL
Graves
C B
CB
McDonald
J M
JM
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D004075:Diglycerides / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D006072:Gossypol / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*; D011112:Polymyxin B / Q000494:pharmacology; D011493:Protein Kinase C / Q000378:metabolism*; D011794:Quercetin / Q000494:pharmacology; D051381:Rats; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D010738:Type C Phospholipases / Q000494:pharmacology
D004075:Diglycerides; D007328:Insulin; D009004:Monosaccharide Transport Proteins; D011794:Quercetin; D011493:Protein Kinase C; D010738:Type C Phospholipases; D005947:Glucose; D011112:Polymyxin B; D006072:Gossypol; D013755:Tetradecanoylphorbol Acetate; C013965:diolein