[Adhesiveness and membrane glycoproteins of human polynuclear neutrophils].
Clinical and biological features of a recently recognized inherited syndrome are reported. This syndrome, Leukocyte Adherence Deficiency, is characterized by recurrent, life-threatening infections. The increased susceptibility to infectious agents is mainly related in the inability of the leukocytes to adhere to certain surfaces, because all adherence-related functions of the neutrophils that lead to bacterial killing are impaired. Adherence deficiency is due to moderate or severe deficiency of three structurally related glycoproteins (MO1, LFA-1 and gp 150,95). All three glycoproteins are heterodimers and share a common subunit whose absence is the cause of the disease.
Pham
H T
HT
Chollet-Martin
S
S
Hakim
J
J
D000954:Antigens, Surface / Q000172:deficiency*; D001798:Blood Proteins / Q000172:deficiency*; D002448:Cell Adhesion; D006023:Glycoproteins / Q000172:deficiency*; D006801:Humans; D016169:Lymphocyte Function-Associated Antigen-1; D016177:Macrophage-1 Antigen; D008565:Membrane Proteins / Q000172:deficiency* / Q000235:genetics; D009504:Neutrophils / Q000502:physiology*; D013577:Syndrome; D014945:Wound Healing
D000954:Antigens, Surface; D001798:Blood Proteins; D006023:Glycoproteins; D016169:Lymphocyte Function-Associated Antigen-1; D016177:Macrophage-1 Antigen; D008565:Membrane Proteins
Adhésivité et glycoprotéines membranaires des polynucléaires neutrophiles humains.