Controlled trial of two keto acid supplements on renal function, nutritional status, and bone metabolism in uremic patients.
In this matched, controlled study, two different types of EAA/KA supplements were compared in uremic patients fed a 30 g protein restricted diet. The patients were paired for age, sex, and underlying renal disease. The supplement with the higher BCKA content resulted in an improvement of renal function, bone metabolism, and a normalization of plasma BCAA concentrations. With both supplements, adequate nutritional status of the patients was maintained. We conclude that the BCKA content of the supplement is of considerable importance for uremic patients on low protein diets.
Meisinger
E
E
Clinic of Nephrology, University of Heidelberg, Mannheim, Federal Republic of Germany.
Strauch
M
M
D000328:Adult; D000601:Amino Acids, Essential / Q000627:therapeutic use; D001842:Bone and Bones / Q000378:metabolism*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007651:Keto Acids / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000178:diet therapy / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D014511:Uremia / Q000178:diet therapy / Q000378:metabolism*
D000601:Amino Acids, Essential; D007651:Keto Acids