Inhibition of purified Escherichia coli leader peptidase by the leader (signal) peptide of bacteriophage M13 procoat.
The leader peptide of bacteriophage M13 procoat inhibited the cleavage of M13 procoat or pre-maltose-binding protein by purified Escherichia coli leader peptidase. This finding confirms inferences that the leader is the primary site of enzyme recognition and suggests a rationale for the rapid hydrolysis of leader peptides in vivo.
Wickner
W
W
Moore
K
K
Dibb
N
N
Geissert
D
D
Rice
M
M
D018528:ATP-Binding Cassette Transporters; D002213:Capsid / Q000378:metabolism*; D036022:Capsid Proteins; D002352:Carrier Proteins / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology*; D029968:Escherichia coli Proteins; D058619:Maltose-Binding Proteins; D008565:Membrane Proteins; D009004:Monosaccharide Transport Proteins; D011480:Protease Inhibitors; D011498:Protein Precursors / Q000378:metabolism*; D021382:Protein Sorting Signals / Q000378:metabolism / Q000494:pharmacology*; D012697:Serine Endopeptidases
D018528:ATP-Binding Cassette Transporters; D036022:Capsid Proteins; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D058619:Maltose-Binding Proteins; D008565:Membrane Proteins; D009004:Monosaccharide Transport Proteins; D011480:Protease Inhibitors; D011498:Protein Precursors; D021382:Protein Sorting Signals; C025668:coat protein, Bacteriophage M13; C461599:maltose transport system, E coli; D010450:Endopeptidases; D012697:Serine Endopeptidases; C026515:type I signal peptidase