Development of chronic renal cyclosporin-A toxicity.
Treatment with cyclosporine in renal transplantation causes an increased incidence of interstitial fibrosis. The degree of interstitial fibrosis seems to be correlated with high cyclosporine consumption and episodes of acute CyA nephrotoxicity. The cause of acute CyA nephrotoxicity seems to be hemodynamic alterations. Whether this is the cause for the chronic nephrotoxicity has still not been shown.
Klintmalm
G
G
Department of Surgery, Baylor University Medical Center, Dallas.
D001379:Azathioprine / Q000009:adverse effects; D001706:Biopsy; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects*; D004334:Drug Administration Schedule; D005355:Fibrosis; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D016030:Kidney Transplantation
D003524:Cyclosporins; D001379:Azathioprine