Synthesis of antiprogestational steroids.
The discovery of the first competitive progesterone antagonist RU 38,486 has initiated an intense search for more potent and more selective anti-progestins. Among several hundreds of compounds under preliminary investigation, biological characterization is most advanced for derivatives RU 38,486, ZK 98,734 and ZK 98,299. These compounds do not only differ in relative potency, but are clearly distinguished by their different behaviour in various animal models. Emphasis is laid on the synthetic problems associated with chemical operations in a sterically crowded environment as represented by structures RU 38,486 and ZK 98,299.
Wiechert
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Research Laboratories, Schering AG, Berlin, F.R.G.
Neef
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D055598:Chemical Phenomena; D002621:Chemistry; D004963:Estrenes / Q000138:chemical synthesis; D006067:Gonanes / Q000138:chemical synthesis; D015735:Mifepristone; D011372:Progestins / Q000037:antagonists & inhibitors*
D004963:Estrenes; D006067:Gonanes; D011372:Progestins; D015735:Mifepristone; C048260:lilopristone; C053238:onapristone