Antibodies to Pf155, a major antigen of Plasmodium falciparum: seroepidemiological studies in Haiti.
The presence of malaria parasites and the serological antibody responses against whole Plasmodium falciparum and the Pf155 antigen were studied in the population of a small rural locality in Haiti in December 1985. Only 7 (1.5%) of the individuals were found to be infected with P. falciparum, the only species observed. Antibodies to P. falciparum were detected in an ELISA in 38.2% of the sera, the positivity rates being age-related. Anti-Pf155 antibodies were detected in 12.5% and 13.6% of individuals by two different techniques used. The anti-Pf155 positivity rates increased only after 25 years of age. No trends were detected for a clear-cut protective value of Pf155 antibodies against clinical malaria and further longitudinally conducted field surveys are needed to satisfactorily assess the potential protective effect of Pf155 antibodies.
Deloron
P
P
Duverseau
Y T
YT
Zevallos-Ipenza
A
A
Magloire
R
R
Stanfill
P S
PS
Nguyen-Dinh
P
P
D000293:Adolescent; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis*; D000953:Antigens, Protozoan / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006205:Haiti; D006801:Humans; D007223:Infant; D008288:Malaria / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D010963:Plasmodium falciparum
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan