[Multivariate analysis of biological markers of excessive consumption of alcohol. Value of lipoprotein parameters].
In order to investigate the usefulness of lipid, lipoprotein and apolipoprotein parameters for detection of intemperate drinkers, 90 adult male subjects with an alcohol consumption above 400 g weekly were compared to 90 matched (age, body weight index) male subjects with an alcohol consumption below 250 g weekly. GGT and MCV were also evaluated. Univariate analysis showed GGT, apolipoprotein A-II and phospholipid-LP no B levels to be parameters the most significantly different between drinkers and controls. Discriminant analysis using six parameters in addition to apolipoprotein A-II allowed to classify correctly 80% of subjects (efficacy) with respect to their alcohol consumption. However, sensitivity of the parameters remains relatively low and a good efficacy is obtained only with a composite index of several parameters.
Parra
H J
HJ
Service de Recherche sur les Lipoprotéines et l'Athérosclérose Serlia, France.
Puchois
P
P
Demarquilly
C
C
Fruchart
J C
JC
D000328:Adult; D000437:Alcoholism / Q000097:blood*; D001053:Apolipoproteins / Q000097:blood*; D001774:Blood Chemical Analysis; D002784:Cholesterol / Q000097:blood*; D005163:Factor Analysis, Statistical; D006801:Humans; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood*; D014280:Triglycerides / Q000097:blood*
D001053:Apolipoproteins; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol
Analyse multivariée d'indicateurs biologiques de consommation excessive d'alcool. Intérêt des paramètres lipoprotéiques.