Genetic activity of trimethoprim in the Salmonella/microsomal screening system.
Trimethoprim, a widely used antibacterial drug was tested for its mutagenic potential in the Ames Salmonella/microsomal test system. The results indicated that, when used in the recommended dose range, the drug produced a several-fold increase in the reversion mutations on his(-)----his+ marker in some of the tester strains, compared with the spontaneous reversions. Dose-dependent curves were also obtained for reversion mutations caused by the drug. Ethyl methanesulfonate and benzo[alpha]pyrene were used a control mutagens.
Rasool
S A
SA
Khan
M A
MA
Alvi
A Z
AZ
Umer
M N
MN
D000818:Animals; D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D014295:Trimethoprim / Q000633:toxicity*
D009153:Mutagens; D014295:Trimethoprim