title: [Immunostimulant preparation made from the antigens of opportunistic microorganisms in the treatment of inflammatory lung diseases].
abstract: The results of the trial of an immunostimulating preparation, consisting of Klebsiella pneumoniae, Proteus, Escherichia coli and Staphylococcus antigenic complexes, on 20 patients with acute pulmonary abscess and bronchiectasis are presented. The preparation was introduced subcutaneously in 5 injections. The preparation was found to have low reactogenicity, and in the course of immunotherapy the manifestations of systemic and local reactions became considerably less pronounced. Immunotherapy produced a good curative effect, objectively manifested by a decrease in coughing and in the amount of sputum gradually changing its character. After the fourth and fifth injections the patients no longer ejected purulent sputum. Fluoroscopic examination revealed a considerable decrease in the size of the pathological focus. The preparation stimulated immunological reactions, and immunization resulted in a considerable increase in the titer of antibodies to all components of the combined preparation, as well as in an increase in the number of functionally active T-lymphocytes, in the blood of the patients.
authors.forename: N B
authors.initials: NB
authors.lastname: Egorova
authors.forename: V N
authors.initials: VN
authors.lastname: Efremova
authors.forename: L S
authors.initials: LS
authors.lastname: Kreĭnin
authors.forename: K G
authors.initials: KG
authors.lastname: Kaverina
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Levashov
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000907:Antibodies, Bacterial / Q000032:analysis; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D001987:Bronchiectasis / Q000276:immunology / Q000628:therapy; D004341:Drug Evaluation; D004926:Escherichia coli / Q000276:immunology; D006801:Humans; D007114:Immunization; D007136:Immunoglobulins / Q000032:analysis; D007709:Klebsiella / Q000276:immunology; D007958:Leukocyte Count; D008169:Lung Abscess / Q000276:immunology / Q000628:therapy; D011014:Pneumonia / Q000276:immunology / Q000628:therapy*; D011511:Proteus / Q000276:immunology; D013210:Staphylococcus / Q000276:immunology; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007136:Immunoglobulins
vernacular_title: Immunostimuliruiushchiĭ preparat iz antigenov uslovno-patogennykh mikroorganizmov pri lechenii vospalitel'nykh zabolevaniĭ legkikh.