title: The single-electron shift as a basis of organic reactivity.
abstract: The configuration mixing (CM) model is applied to the building of a simple reaction profile for nucleophilic addition to a carbonyl group. The analysis leads us to conclude that essentially all the so-called polar reaction pathways in organic chemistry are single-electron shift processes and intimately related to the class of electron transfer (ET) reactions. The implication of this finding to a variety of organic reactions, including oxidation-reduction of the NADH/NAD+ coenzyme couple, is discussed.
authors.forename: A
authors.initials: A
authors.lastname: Pross
authors.forename: D M
authors.initials: DM
authors.lastname: Chipman
mesh_terms: D002625:Chemistry, Organic; D004583:Electrons; D005609:Free Radicals; D008956:Models, Chemical; D009243:NAD; D055601:Organic Chemistry Phenomena
chemical_list: D005609:Free Radicals; D009243:NAD