title: The effect of indomethacin on the response of protein synthesis to feeding in rats and man.
abstract: Protein synthesis was measured in muscle of fed and fasted rats. Synthesis rates were 29% higher with feeding. Treatment with indomethacin before feeding completely blocked the stimulation of protein synthesis. Whole-body protein synthesis was measured in six healthy volunteers with [15N]glycine in fasted and fed states. Feeding increased synthesis rates by 50%. An oral dose of indomethacin 2 h before the measurement of protein synthesis had no effect in either the fasted or fed state.
authors.forename: M A
authors.initials: MA
authors.lastname: McNurlan
authors.forename: K C
authors.initials: KC
authors.lastname: McHardy
authors.forename: J
authors.initials: J
authors.lastname: Broom
authors.forename: E
authors.initials: E
authors.lastname: Milne
authors.forename: L M
authors.initials: LM
authors.lastname: Fearns
authors.forename: P J
authors.initials: PJ
authors.lastname: Reeds
authors.forename: P J
authors.initials: PJ
authors.lastname: Garlick
mesh_terms: D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005215:Fasting; D005502:Food; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D009124:Muscle Proteins / Q000096:biosynthesis; D009584:Nitrogen / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats
chemical_list: D001786:Blood Glucose; D007328:Insulin; D009124:Muscle Proteins; D009584:Nitrogen; D007213:Indomethacin