[Pharmacokinetics of pefloxacin in burn patients].
The aim of this study was to evaluate pharmacokinetics of pefloxacin (PFL) in burn patients (n = 11), compared with 5 non burned subjects. The role of the extent of the burn and the delay after initial thermal trauma were also evaluated. Our results suggest that neither the extent of the burn, nor the delay of the study play a role. Compared with non-burned subjects, burn patients exhibit a shorter elimination half-life, but modifications in dosage regimen are not required.
Potel
G
G
Service des Urgences, CHU, Hôtel-Dieu, Nantes.
Meignier
M
M
Touzé
M D
MD
Montay
G
G
Drugeon
H B
HB
Baron
D
D
D000328:Adult; D000704:Analysis of Variance; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D002056:Burns / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D009643:Norfloxacin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D015366:Pefloxacin
D000890:Anti-Infective Agents; D015366:Pefloxacin; D009643:Norfloxacin
Pharmacocinétique de la Péfloxacine chez le brûlé.