The relevance of hyperresponsiveness but not of atopy to FEV1 decline. Preliminary results in a working population.
Five-year FEV1 decline in 329 working men was shown to be significantly related only among eversmokers to methacholine bronchial hyperresponsiveness (assessed at the end of follow-up), allergic rhinitis and rhinitis induced by cold air, independent of asthma and FEV1 level. Positive skin prick test was not associated with FEV1 decline.
Annesi
I
I
INSERM U 169, Villejuif, France.
Neukirch
F
F
Orvoen-Frija
E
E
Oryszczyn
M P
MP
Korobaeff
M
M
Doré
M F
MF
Kauffmann
F
F
D000328:Adult; D000402:Airway Obstruction / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology*; D001985:Bronchial Provocation Tests; D003080:Cold Temperature; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008448:Maximal Expiratory Flow Rate; D016210:Methacholine Chloride; D008688:Methacholine Compounds; D008875:Middle Aged; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D012882:Skin Tests; D012907:Smoking; D006113:United Kingdom
D008688:Methacholine Compounds; D016210:Methacholine Chloride