Diffusing lung capacity and cyclosporine in patients with heart transplants.
Pulmonary function studies were performed in 10 patients undergoing surgery for heart transplantation. The study was repeated 6 to 12 months after surgery. The comparison between data before and after transplantation showed an overall improvement in lung function indices, except for the lung diffusing capacity (DLCO). A mean 14% reduction (p less than 0.01) of DLCO was observed. In the absence of evidence of other lung disease or rejection reaction in these patients, this finding may be related to a side effect of cyclosporine on the lung and deserves further investigation.
Casan
P
P
Sanchis
J
J
Cladellas
M
M
Amengual
M J
MJ
Caralps
J M
JM
D000328:Adult; D003524:Cyclosporins / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000502:physiology; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged
D003524:Cyclosporins