title: Contrast injection bradycardia during coronary angiography: effects in the denervated human heart.
abstract: To assess the contribution of cardiac innervation toward understanding the mechanisms of bradycardia during contrast coronary angiography, heart rate (HR) responses in eight patients after heart transplantation were compared with 10 normal patients (control), 10 patients with coronary artery disease (CAD) and normal ventricular function, and 10 patients with congestive cardiomyopathy and normal coronary arteries. The longest P-P interval was measured beat to beat before (HR 1) and after (HR 2) coronary angiography. The coronary vessel perfusing the sinus node did not influence HR 2 responses within each group. HR 1 was significantly different from HR 2 (p less than 0.05) in the control and CAD groups but was not different in the transplant and cardiomyopathy groups. Compared with the control group, the percent decrease in HR was significantly less in transplant patients than in patients with cardiomyopathy. Thus contrast injection bradycardia is absent in denervated patients after heart transplant, and this response is markedly blunted in cardiomyopathy patients who are known to have diminished vasodepressor reflexes. These findings suggest that the bradycardia response is probably a neurally mediated phenomenon.
authors.forename: J
authors.initials: J
authors.lastname: Mukharji
authors.forename: M D
authors.initials: MD
authors.lastname: Thames
authors.forename: M
authors.initials: M
authors.lastname: Newton
authors.forename: P D
authors.initials: PD
authors.lastname: Hirsh
authors.forename: S A
authors.initials: SA
authors.lastname: Lewis
authors.forename: R B
authors.initials: RB
authors.lastname: Rehr
authors.forename: M J
authors.initials: MJ
authors.lastname: Cowley
authors.forename: M L
authors.initials: ML
authors.lastname: Hess
authors.forename: A
authors.initials: A
authors.lastname: Hastillo
authors.forename: R R
authors.initials: RR
authors.lastname: Lower
mesh_terms: D000328:Adult; D000792:Angiography / Q000009:adverse effects*; D001919:Bradycardia / Q000209:etiology*; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging; D003714:Denervation; D003973:Diatrizoate / Q000009:adverse effects; D003974:Diatrizoate Meglumine / Q000009:adverse effects; D004338:Drug Combinations / Q000009:adverse effects; D005260:Female; D006321:Heart / Q000294:innervation*; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; C027278:urovision