[Decreased sensitivity to the hypoglycemic action of insulin in animals with a lowered blood heparin concentration].
It has been shown that in animals with reduced heparin blood concentration the hypoglycemic insulin action was considerably low. This was established for rats with alloxan diabetes and ageing rats with depressed anticoagulation system and atherosclerosis enhanced by prolonged atherogenic diet. With insulin injection (0.2-0.3 U/200 g), blood sugar concentration in such animals was 2-2.5 times lower than in normal ones. The compensation of endogenous heparin deficiency by an intravenous injection of heparin normalizes the reaction of animals to exogenous insulin.
Ul'ianov
A M
AM
Shapiro
F B
FB
Bazaz'ian
G G
GG
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D004036:Diet, Atherogenic; D006493:Heparin / Q000097:blood* / Q000494:pharmacology; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced*; D007328:Insulin / Q000494:pharmacology*; D007330:Insulin Antibodies / Q000032:analysis; D007333:Insulin Resistance; D008297:Male; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D007330:Insulin Antibodies; D006493:Heparin
Snizhenie chuvstvitel'nosti k gipoglikemicheskomu deĭstviiu insulina u zhivotnykh s ponizhennoĭ kontsentratsieĭ geparina v krovi.