Lung immunogenicity, rejection, and obliterative bronchiolitis.
Evidence suggests that obliterative bronchiolitis (OB) following human heart-lung transplantation is a form of allograft rejection related to augmented expression of class II major histocompatibility complex antigens (MHCII) on airway epithelium and mediated by activated T cells. Other forms of OB, including those related to viral infection and autoimmune disease, may reflect a similar mechanism.
Burke
C M
CM
Glanville
A R
AR
Theodore
J
J
Robin
E D
ED
D001991:Bronchitis / Q000276:immunology*; D006084:Graft Rejection; D006680:HLA Antigens / Q000276:immunology*; D016027:Heart Transplantation; D006801:Humans; D008168:Lung / Q000276:immunology; D016040:Lung Transplantation; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology
D006680:HLA Antigens