Identification of human chorionic gonadotropin (HCG) secreting cells and other cell types using antibody to HCG and a new monoclonal antibody (mABlu-5) in cultures of human placental villi.
We have identified cells which secrete human chorionic gonadotropin (HCG) of cultures if first trimester placental villi. As a first step, we identified epithelial cells using a new monoclonal antibody. We then added HCG antibodies to the cultured cells. We found that syncytiotrophoblast (and not cytotrophoblast), Hofbauer cells and some mesenchymal cells stained with HCG antibodies.
Frauli
M
M
Department of Obstetrics and Gynecology, University of Basle, Switzerland.
Ludwig
H
H
D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D002478:Cells, Cultured; D006063:Chorionic Gonadotropin / Q000276:immunology / Q000378:metabolism*; D002824:Chorionic Villi / Q000166:cytology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D011247:Pregnancy; D011261:Pregnancy Trimester, First
D000911:Antibodies, Monoclonal; D006063:Chorionic Gonadotropin