title: CALLA-negative, TdT- and CD7-positive acute lymphoblastic leukemia: a phenotype associated with poor prognosis.
abstract: Eight ALL patients displaying a CD7+, Tdt+, CD10-, T MoAbs-, myeloid MoAbs-, AP+ phenotype are described. Some patients showed well-known risk factors such as cytogenetic abnormalities, high WBC count, mediastinal mass, and/or organomegalies. The clinical behaviour was very poor and only one patient is in CR and off therapy. Therefore such a pre-T phenotype, although sometimes associated with the other risk factors, could be considered a poor prognosis phenotype.
authors.affiliation: Hematology Section of the Department of Human Biopathology, University La Sapienza, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: De Rossi
authors.forename: M A
authors.initials: MA
authors.lastname: Aloe Spiriti
authors.forename: A
authors.initials: A
authors.lastname: Cafolla
authors.forename: R
authors.initials: R
authors.lastname: Gastaldi
authors.forename: F
authors.initials: F
authors.lastname: Lo Coco
authors.forename: M
authors.initials: M
authors.lastname: Lopez
authors.forename: M
authors.initials: M
authors.lastname: Luciani
authors.forename: D
authors.initials: D
authors.lastname: Pasqualetti
authors.forename: A M
authors.initials: AM
authors.lastname: Testi
authors.forename: F
authors.initials: F
authors.lastname: Mandelli
mesh_terms: D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D002648:Child; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D008297:Male; D010641:Phenotype; D011379:Prognosis; D012307:Risk Factors; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal