title: Lung immunogenicity, rejection, and obliterative bronchiolitis.
abstract: Evidence suggests that obliterative bronchiolitis (OB) following human heart-lung transplantation is a form of allograft rejection related to augmented expression of class II major histocompatibility complex antigens (MHCII) on airway epithelium and mediated by activated T cells. Other forms of OB, including those related to viral infection and autoimmune disease, may reflect a similar mechanism.
authors.forename: C M
authors.initials: CM
authors.lastname: Burke
authors.forename: A R
authors.initials: AR
authors.lastname: Glanville
authors.forename: J
authors.initials: J
authors.lastname: Theodore
authors.forename: E D
authors.initials: ED
authors.lastname: Robin
mesh_terms: D001991:Bronchitis / Q000276:immunology*; D006084:Graft Rejection; D006680:HLA Antigens / Q000276:immunology*; D016027:Heart Transplantation; D006801:Humans; D008168:Lung / Q000276:immunology; D016040:Lung Transplantation; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D006680:HLA Antigens