title: Drug therapy in hypoxic-ischemic cerebral insults and intraventricular hemorrhage of the newborn.
abstract: Recent progress in understanding the pathophysiology of hypoxic-ischemic encephalopathies and intraventricular hemorrhages have enabled us to propose new therapeutic modalities in preventing the development and severity of these disorders in the newborn. Because neuronal damage may be reversible under certain conditions, appropriate evaluation of these drugs (single or in combination) is very important in the continuous attempt to ameliorate the neurodevelopmental outcome of these infants. An interventionist attitude should prove to be a better alternative than a supportive one.
authors.affiliation: Department of Pediatrics and of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Chemtob
authors.forename: N
authors.initials: N
authors.lastname: Laudignon
authors.forename: J V
authors.initials: JV
authors.lastname: Aranda
mesh_terms: D001238:Asphyxia Neonatorum / Q000188:drug therapy* / Q000209:etiology; D001463:Barbiturates / Q000627:therapeutic use; D002545:Brain Ischemia / Q000188:drug therapy* / Q000209:etiology; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D005311:Fetal Hypoxia / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007223:Infant; D007231:Infant, Newborn; D010197:Pancuronium / Q000627:therapeutic use; D011247:Pregnancy
chemical_list: D001463:Barbiturates; D010197:Pancuronium; D007213:Indomethacin