[Exploration of endogenous mechanisms controlling the inflammatory reaction, by the study of counter-irritation: release of prostaglandins, formation of kinins and accumulation of leukocytes].
This review was focused on counter irritation by turpentine in the rat. The involvement of sympathetic system, adrenal steroids, beta-endorphin, axon reflexes, haptoglobin, alpha-2-macroglobulin, complement activation, prostaglandin synthesis, kinin formation and leukocyte accumulation was considered as possible explanation of the anti-inflammatory effect of counter irritation by turpentine. The main mechanism consists of the reduction of leucocyte accumulation.
Damas
J
J
Institut Léon-Fredericq, Physiologie humaine normale et pathologique, Liege, Belgique.
Deflandre
E
E
D000818:Animals; D001808:Blood Vessels / Q000187:drug effects; D003165:Complement System Proteins / Q000378:metabolism; D006168:Guinea Pigs; D007249:Inflammation / Q000378:metabolism* / Q000473:pathology; D007705:Kinins / Q000378:metabolism*; D007958:Leukocyte Count / Q000187:drug effects*; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D014425:Turpentine / Q000494:pharmacology*
D007705:Kinins; D011453:Prostaglandins; D003165:Complement System Proteins; D014425:Turpentine
Exploration des mécanismes endogènes contrôlant la réaction inflammatoire, par l'étude de la contre-irritation: libération de prostaglandines, formation de kinines et accumulation des leucocytes.