Comparison of adjuvanticity and autoantibody inducing capacity of endotoxin and radio-detoxified endotoxin in mice.
Endotoxin (LPS) and radio-detoxified endotoxin (RD-LPS: 150 kGy 60Co-gamma irradiated) preparations were compared in mice (C57Bl X CBA: F1/Rapo) for capacity to enhance the immune response against sheep red blood cells and to induce the production of antibody against autologous (bromelain-treated) erythrocytes. As RD-LPS retains its capacity to stimulate immune response against heterologous antigen, it may be used as an immuno-adjuvant. The LPS preparation gave rise to a significant increase of autoreactive cells. However, RD-LPS activated the autoantibody forming cells only to a very small degree.
Klimovich
V B
VB
Samoilovich
M P
MP
Denisova
G N
GN
Sirota
N S
NS
Schuls
T S
TS
Zeludov
V I
VI
Bertók
L
L
D000276:Adjuvants, Immunologic; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D004731:Endotoxins / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D004926:Escherichia coli; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male; D051379:Mice
D000276:Adjuvants, Immunologic; D001323:Autoantibodies; D004731:Endotoxins; D008070:Lipopolysaccharides