title: [Inadequate treatment in multibacillary leprosy and incubation times for relapses].
abstract: Among a population of over 500 PB patients treated with different regimens, 6 multibacillary relapses were detected: 5 in patients erroneously classified as PB but in reality MB with a low bacterial load, one patient was PB at the start. Treatment regimens had been: 10 weekly doses of RMP either 600 mg (1 case) or 900 mg (1 case) two successive doses of RMP 1500 mg (1 case) a single dose of RMP 40 mg/K (3 cases). Four MB patients with proven DDS-R relapsed after a single dose of RMP either 20 mg/K (1 case) or 40 mg/K (3 cases). The two strains isolated were RMP sensitive. Seven of the 10 relapses appeared within 24 months after start of treatment.
authors.forename: S R
authors.initials: SR
authors.lastname: Pattyn
authors.forename: J A
authors.initials: JA
authors.lastname: Husser
authors.forename: L
authors.initials: L
authors.lastname: Janssens
authors.forename: S
authors.initials: S
authors.lastname: Grillone
authors.forename: J
authors.initials: J
authors.lastname: Bourland
mesh_terms: D003622:Dapsone / Q000627:therapeutic use*; D006801:Humans; D007918:Leprosy / Q000188:drug therapy*; D012008:Recurrence; D012293:Rifampin / Q000627:therapeutic use*
chemical_list: D003622:Dapsone; D012293:Rifampin
vernacular_title: Traitements insuffisants dans la lèpre multibacillaire et temps d'incubation des rechutes.