Role of early and late oestrogenic effects on implantation in the mouse.
Oestrogen action in the uterus is expressed in an early phase (Phase I) and a late phase (Phase II). The role of this biphasic oestrogen action in implantation is not clear. To determine the relative importance of Phase I and II responses, triphenylethylene compounds (CI-628, LY-117018, nafoxidine, clomiphene citrate and tamoxifen) and oestrogens (oestriol and oestradiol-17 beta) were used in a physiologically relevant experimental system for studying implantation. All compounds elicited uterine water imbibition to various degrees in ovariectomized-progesterone-treated mice at 6 h (Phase I response) and their effectiveness in inducing implantation in delayed implanting mice correlated with their respective potency to increase uterine wet weight. This suggests that Phase I might be an essential component of oestrogen action in implantation and that the efficiency of a compound to elicit a Phase I response might serve as a predictive indicator of its potential action on implantation.
Huet
Y M
YM
Department of Physiology, Ralph L. Smith Research Center, University of Kansas Medical Center, Kansas City 66103.
Dey
S K
SK
D000818:Animals; D002996:Clomiphene / Q000494:pharmacology; D010064:Embryo Implantation / Q000187:drug effects*; D010065:Embryo Implantation, Delayed / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology; D004964:Estriol / Q000494:pharmacology; D004967:Estrogens / Q000502:physiology*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009256:Nafoxidine / Q000494:pharmacology; D009594:Nitromifene / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D010052:Ovariectomy; D011374:Progesterone / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology; D013629:Tamoxifen / Q000494:pharmacology; D013876:Thiophenes / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects / Q000502:physiology*
D004967:Estrogens; D011759:Pyrrolidines; D013876:Thiophenes; D013629:Tamoxifen; D002996:Clomiphene; D011374:Progesterone; D009256:Nafoxidine; D004958:Estradiol; D009594:Nitromifene; C025430:LY 117018; D004964:Estriol