Transient expression of choline acetyltransferase-like immunoreactivity in Purkinje cells of the developing rat cerebellum.
The expression of choline acetyltransferase (ChAT)-like immunoreactivity was studied immunohistochemically in the cerebelli of developing rats. Brains were examined from the day of birth (postnatal day 1: P1) until adulthood. From P4 through P21, several Purkinje cells in the uvula, nodule, and flocculus of the cerebellum demonstrated ChAT-like immunoreactivity. After P23, no ChAT-positive neurons were observed in any region of the cerebellum. This finding paralleled the transient expression of acetylcholinesterase in Purkinje cells of these same cerebellar areas during development.
Gould
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Butcher
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D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002525:Cerebellar Cortex / Q000254:growth & development; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D005260:Female; D005455:Fluorescent Antibody Technique; D007120:Immunochemistry; D008297:Male; D011689:Purkinje Cells / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase