Erythrocyte repopulation after allogeneic bone marrow transplantation. Analysis using erythrocyte antigens.
Blood samples from 31 of 50 consecutive patients receiving bone marrow from an HLA-identical and mixed lymphocyte culture-nonreactive sibling were investigated for the presence of donor and autologous erythrocytes. Simple serological techniques using antigenic differences between donor and recipient and a blood transfusion policy taking these differences into account made this study possible. A total of 71% of the patients had donor erythrocytes demonstrable 4 weeks after bone marrow transplantation; almost all patients did so after 2 months. Disappearance or absence of donor red cells indicated poor patient prognosis. Persistence or reappearance of autologous erythrocytes in small percentages (0.05-10%) occurred without relapse of leukemia. Reappearance in high percentage (50-100%) indicated relapse.
van Dijk
B A
BA
Blood Transfusion Service, St. Radboud University Hospital, Nijmegen, The Netherlands.
Drenthe-Schonk
A M
AM
Bloo
A
A
Kunst
V A
VA
Janssen
J T
JT
de Witte
T J
TJ
D000943:Antigens, Differentiation / Q000032:analysis*; D016026:Bone Marrow Transplantation; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D011379:Prognosis; D013997:Time Factors; D014019:Tissue Donors; D014184:Transplantation, Homologous
D000943:Antigens, Differentiation