Disparate effects of ACTH (1-24) and corticosterone on lipoprotein lipase in rat adipose tissue.
The effects of corticosterone and ACTH(1-24) on lipoprotein lipase (LPL) activity of rat epididymal fat tissue were studied. Hypercorticism induced by s.c. administration of 10 mg corticosterone acetate for 3 days led to a decrease in LPL activity. This decrease could be prevented by treatment of the rats simultaneously with synthetic ACTH(1-24). Adrenalectomy also reduced LPL activity. Corticosterone and ACTH(1-24) treatment had a similar effect on LPL activity in adrenalectomized and intact rats. These results indicate that ACTH(1-24) may affect adipose tissue LPL in the rat by a mechanism in which corticosterone is not involved.
Baggen
M G
MG
Department of Medicine (III), University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands.
Jansen
H
H
Lammers
R
R
Verschoor
L
L
Birkenhäger
J C
JC
D000273:Adipose Tissue / Q000201:enzymology*; D000315:Adrenalectomy; D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology*; D003366:Cosyntropin / Q000494:pharmacology*; D004822:Epididymis / Q000187:drug effects; D007328:Insulin / Q000097:blood; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D003366:Cosyntropin; D008071:Lipoprotein Lipase; D003345:Corticosterone