Correlation between estrophilin immunoreactivity and androgen receptor-binding activity in meningiomas.
Estrogen receptor (ER) analysis was performed with an enzyme immunoassay using monoclonal antibodies against human ER protein (estrophilin) in 70 meningiomas. [3H]methyltrienolone, a synthetic androgen, was used for concurrent determination of the androgen receptor (AR)-binding activity. Low levels of ER immunoreactivity were detected in 36 cases (51%), whereas moderately high AR-binding activity was demonstrated in 33 (47%) tumors. A positive correlation between ER immunoreactivity and AR-binding activity is indicative for an estrogen regulation of AR via the ER system. The presence of gonadal steroid receptors in a large proportion of meningiomas and the tendency for a dependence of receptor concentrations on the histological subtype could have implications for tumor therapy.
Lesch
K P
KP
Schott
W
W
Engl
H G
HG
Gross
S
S
D000911:Antibodies, Monoclonal; D002352:Carrier Proteins / Q000032:analysis; D004963:Estrenes; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism*; D008579:Meningioma / Q000378:metabolism*; D015741:Metribolone; D008875:Middle Aged; D011944:Receptors, Androgen / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000032:analysis*; D014316:Tritium
D000911:Antibodies, Monoclonal; D002352:Carrier Proteins; D004963:Estrenes; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; C010140:estrophilin; D014316:Tritium; D015741:Metribolone