title: The islets of Langerhans in uremic patients receiving chronic hemodialysis.
abstract: Ten autopsied cases of uremia (none with diabetes mellitus) who had been treated with hemodialysis were studied histopathologically. Hyaline replacement of islets of Langerhans was found in 6 out of 10 cases, while such a change was observed in only 1 of 15 control non hemodialzyed controls. These 6 cases had received hemodialysis therapy for a duration of more than 2 years and 10 months. The hyaline material in the islets of Langerhans was confirmed as the presence of amyloid by electron microscopy. Clinically, urinary glucose was present in 1 out of 3 patients and the blood glucose level was moderately elevated in 2 other cases. Therefore, it should be emphasized that care should be taken about glucose tolerance in uremic patients receiving chronic hemodialysis.
authors.forename: K
authors.initials: K
authors.lastname: Suda
authors.forename: R
authors.initials: R
authors.lastname: Ariwa
mesh_terms: D000328:Adult; D000368:Aged; D000682:Amyloid / Q000032:analysis; D005260:Female; D005947:Glucose / Q000032:analysis; D006801:Humans; D007515:Islets of Langerhans / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014511:Uremia / Q000378:metabolism / Q000473:pathology* / Q000628:therapy
chemical_list: D000682:Amyloid; D005947:Glucose