Calcitonin suppresses gastric emptying of a radiolabelled solid meal in humans.
The effects on gastric emptying of calcitonin/i.v. 1.5 i.u. kg-1 body mass bolus or 10 i.u. followed by infusion to overall 1.5 i.u. kg-1 body mass dose vs placebo were studied in four healthy volunteers and in four patients with an active peptic ulcer. Gastric emptying of a radiolabelled solid meal was surveyed. Pronounced delay in gastric emptying was observed in all studied subjects, mean transit time MTT90 calcitonin 39.2 +/- 0.85 min vs placebo 32.8 +/- 1.31 min, P less than 0.001.
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D000328:Adult; D002116:Calcitonin / Q000494:pharmacology*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate
D009942:Organometallic Compounds; D004369:Pentetic Acid; D002116:Calcitonin; D016284:Technetium Tc 99m Pentetate