title: Redesigning nature's poisons to create anti-tumor reagents.
abstract: Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.
authors.affiliation: Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.
authors.forename: E S
authors.initials: ES
authors.lastname: Vitetta
authors.forename: R J
authors.initials: RJ
authors.lastname: Fulton
authors.forename: R D
authors.initials: RD
authors.lastname: May
authors.forename: M
authors.initials: M
authors.lastname: Till
authors.forename: J W
authors.initials: JW
authors.lastname: Uhr
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D002986:Clinical Trials as Topic; D006801:Humans; D000922:Immunotoxins / Q000493:pharmacokinetics / Q000633:toxicity; D009374:Neoplasms, Experimental / Q000628:therapy; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D000922:Immunotoxins; D011994:Recombinant Proteins