title: Relationship between platelet cytosolic free calcium concentration and plasma renin activity.
abstract: 1. Plasma renin activity (PRA) and platelet cytosolic free calcium concentration ([Ca2+]i) were simultaneously determined in 18 untreated essential hypertensive subjects and 17 normotensive controls. A significant positive correlation was found between [Ca2+]i and PRA (slope = 42 nmol/l/ng/ml/h) in these 35 subjects. 2. Two determinations more than one week apart in nine subjects confirmed the parallel fluctuations of [Ca2+]i and PRA. A strict sodium restriction produced a progressive PRA elevation associated with a parallel rise in [Ca2+]i in one subject. 3. These results are consistent with the hypothesis that angiotensin II causes a concentration-dependent calcium mobilization.
authors.affiliation: Laboratoire de Pharmacologie, INSERM U7, Faculté de Médecine Necker-Enfants Malades, Paris, France.
authors.forename: K H
authors.initials: KH
authors.lastname: Le Quan Sang
authors.forename: J L
authors.initials: JL
authors.lastname: Elghozi
authors.forename: P
authors.initials: P
authors.lastname: Meyer
authors.forename: M A
authors.initials: MA
authors.lastname: Devynck
mesh_terms: D001792:Blood Platelets / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D003600:Cytosol / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D012083:Renin / Q000097:blood*
chemical_list: D012083:Renin; D002118:Calcium