title: Serological studies in Crohn's disease.
abstract: ELISA and immunofluorescence tests were carried out on sera from patients with Crohn's disease and ulcerative colitis. The results indicate that mean antibody levels to Yersinia enterocolitica types O:9 and O:3 and Klebsiella pneumoniae, but not Pseudomonas maltophilia, are significantly higher in these patients than in control subjects. There are differing antibody levels in ileal and colonic disease, and there is a significant fall in antibody levels 9-12 months after remission from clinical symptoms in patients providing serial serum samples. However, there is no correlation between the severity of the disease and antibody titres.
authors.forename: J P
authors.initials: JP
authors.lastname: Ibbotson
authors.forename: P E
authors.initials: PE
authors.lastname: Pease
authors.forename: R N
authors.initials: RN
authors.lastname: Allan
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis*; D003092:Colitis / Q000276:immunology / Q000382:microbiology; D003093:Colitis, Ulcerative / Q000276:immunology / Q000382:microbiology; D003424:Crohn Disease / Q000276:immunology* / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006090:Gram-Negative Bacteria / Q000276:immunology; D006801:Humans; D007079:Ileitis / Q000276:immunology / Q000382:microbiology; D007074:Immunoglobulin G / Q000032:analysis; D007711:Klebsiella pneumoniae / Q000276:immunology*; D011549:Pseudomonas / Q000276:immunology; D015008:Yersinia enterocolitica / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G