title: Effects of cyclosporine in recent-onset juvenile type 1 diabetes: impact of age and duration of disease.
abstract: Administration of cyclosporine resulted in reduced insulin requirements and improved glycemic control in patients with insulin-dependent diabetes mellitus of recent onset, but the drug was less effective in young children. Renal toxic effects and other problems related to therapy resolved after discontinuation of the drug. Sustained remission seemed dependent on continued administration of cyclosporine. Although short-term control of diabetes may be achieved in some patients, more studies are needed to determine whether cyclosporine can be given safely as maintenance therapy to maintain glycemic control and prevent the long-term consequences of the disease.
authors.affiliation: Department of Medicine, University Hospital, London, Ontario, Canada.
authors.forename: C R
authors.initials: CR
authors.lastname: Stiller
authors.forename: J
authors.initials: J
authors.lastname: Dupre
authors.forename: M
authors.initials: M
authors.lastname: Gent
authors.forename: D
authors.initials: D
authors.lastname: Heinrichs
authors.forename: M R
authors.initials: MR
authors.lastname: Jenner
authors.forename: P A
authors.initials: PA
authors.lastname: Keown
authors.forename: A
authors.initials: A
authors.lastname: Laupacis
authors.forename: R
authors.initials: R
authors.lastname: Martell
authors.forename: N W
authors.initials: NW
authors.lastname: Rodger
authors.forename: B M
authors.initials: BM
authors.lastname: Wolfe
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D003524:Cyclosporins / Q000009:adverse effects / Q000627:therapeutic use*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D004341:Drug Evaluation; D005951:Glucose Tolerance Test; D006801:Humans; D007223:Infant; D007328:Insulin / Q000008:administration & dosage; D007515:Islets of Langerhans / Q000276:immunology; D007674:Kidney Diseases / Q000139:chemically induced; D008875:Middle Aged; D013997:Time Factors
chemical_list: D001323:Autoantibodies; D003524:Cyclosporins; D007328:Insulin