Glucose-induced insulin response and insulin sensitivity is not related to HLA-type but to age in young siblings of type 1 (insulin-dependent) diabetic patients.
Glucose-induced insulin response and insulin sensitivity were studied in 32 HLA-identical, 38 haplo-identical and 24 non-identical, islet-cell-antibody-negative, healthy siblings of young Type 1 (insulin-dependent) diabetic patients (age range 10-28 years). No significant differences were obtained between HLA-identical, HLA-haplo-identical siblings and HLA-non-identical siblings in insulin response using an i.v. glucose infusion test even when the insulin sensitivity as estimated by the somatostatin-insulin-glucose infusion test was taken into account. A significant inverse correlation to age was found for both insulin response (r = -0.24, p = 0.02) and insulin sensitivity (r = -0.36, p less than 0.01) in the young siblings studied.
Lindgren
F
F
Department of Pediatrics, Karolinska Institute, Sachs' Children's Hospital, Stockholm, Sweden.
Dahlquist
G
G
Efendic
S
S
Möller
E
E
Persson
B
B
Thalme
B
B
Olsson
M L
ML
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000235:genetics; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D004200:Diseases in Twins; D005260:Female; D005951:Glucose Tolerance Test; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000235:genetics; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D012307:Risk Factors
D001323:Autoantibodies; D006680:HLA Antigens; D007328:Insulin