Preinduction cervical softening with endocervical PGE2 gel. A multi-center trial.
In a prospective, randomized trial, a single dose of PGE2 gel, 0.5 mg (2.5 ml), was given to 416 low Bishop Score patients 12 h prior to indicated oxytocin induction and compared with 404 non-gel controls. Successful initial induction was achieved in 83% of the treated and 58% of the non-treated subjects. In addition the induction-delivery interval was shortened (median times 9.0 h vs. 11.3 h) and fewer cesarean sections were performed (16% vs. 21%) in the PGE2 gel series. The endocervical administration of PGE2 was well tolerated and, provided care is taken to avoid excess extra-amniotic placement, systemic PGE2 effects are minimal.
Noah
M L
ML
DeCoster
J M
JM
Fraser
T J
TJ
Orr
J D
JD
D000328:Adult; D002585:Cesarean Section; D002986:Clinical Trials as Topic; D015232:Dinoprostone; D005260:Female; D005782:Gels; D006801:Humans; D007231:Infant, Newborn; D007751:Labor, Induced; D011247:Pregnancy; D011379:Prognosis; D011446:Prospective Studies; D011458:Prostaglandins E / Q000008:administration & dosage* / Q000009:adverse effects; D011897:Random Allocation
D005782:Gels; D011458:Prostaglandins E; D015232:Dinoprostone