Tubulointerstitial nephritis by Tamm-Horsfall glycoprotein or egg white component.
Experimental tubulointerstitial nephritis (TIN) was induced in Wistar rats and New Zealand white rabbits by direct intrarenal inoculation of Tamm-Horsfall glycoprotein (THG) or egg white component (egg white A). After five immunizations of THG or egg white A with complete Freund's adjuvant (CFA), direct intrarenal inoculation of THG or egg white A also induced more severe TIN in the inoculated kidney. By the 7th day, in 1 of the animals with immunizations and then intrarenal inoculation of THG, the inoculated kidney was swollen and appeared necrotic. By the 28th day, in 1 of those receiving immunizations and intrarenal inoculation of THG, the inoculated kidney became contracted. TIN was observed in three experimental models, namely (a) direct intrarenal inoculation of THG or egg white A; (b) five immunizations of THG and (c) immunizations and then intrarenal inoculations of THG or egg white A. The most severe TIN was observed in the latter model.
Nagai
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Nagai Clinic, Osaka, Japan.
Nagai
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D000818:Animals; D000917:Antibody Formation; D004529:Egg White; D005455:Fluorescent Antibody Technique; D007111:Immunity, Cellular; D007114:Immunization; D007117:Immunization, Secondary; D007668:Kidney / Q000276:immunology / Q000473:pathology; D009088:Mucoproteins; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D058949:Uromodulin
D009088:Mucoproteins; D058949:Uromodulin