Intravenous indomethacin and oxycone-papaverine in the treatment of acute renal colic. A double-blind study.
In a prospective double-blind, cross-over study, 61 patients with acute renal colic were treated with either indomethacin (50 mg) or oxycone-papaverine (5 mg + 50 mg) administered intravenously. For those patients requiring a second injection the drugs were reversed. The intensity of pain was evaluated before and 20 min after each injection according to an analogue visual scale 0 to 100. Both drug regimens provided comparable and significant pain relief; a pain score of less than 20 appeared to be satisfactory and was achieved in almost all cases.
Jönsson
P E
PE
Olsson
A M
AM
Petersson
B A
BA
Johansson
K
K
D000208:Acute Disease; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003061:Codeine / Q000031:analogs & derivatives*; D003085:Colic / Q000188:drug therapy*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects / Q000627:therapeutic use*; D007275:Injections, Intravenous; D007674:Kidney Diseases / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010098:Oxycodone / Q000009:adverse effects / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy; D010208:Papaverine / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies
D004338:Drug Combinations; D010098:Oxycodone; D010208:Papaverine; D003061:Codeine; D007213:Indomethacin