title: Penetration of ceftazidime into heart valves and subcutaneous and muscle tissue of patients undergoing open-heart surgery.
abstract: Patients undergoing open-heart surgery were given an intravenous bolus injection of 2 g of ceftazidime as a single dose over a period of 5 min. Within 12 h, ceftazidime concentrations in serum declined from 55.8 to 3.9 mg/liter. Subcutaneous tissue concentrations of the drug decreased from 21.0 to 2.7 micrograms/g, and muscle concentrations decreased from 34.5 to 2.5 micrograms/g. Ceftazidime concentrations in cardiac valvular tissue were even higher than those in muscle or fat, declining from 37.4 to 6.3 micrograms/g within 10 h.
authors.forename: U
authors.initials: U
authors.lastname: Frank
authors.forename: I
authors.initials: I
authors.lastname: Kappstein
authors.forename: E
authors.initials: E
authors.lastname: Schmidt-Eisenlohr
authors.forename: V
authors.initials: V
authors.lastname: Schlosser
authors.forename: G
authors.initials: G
authors.lastname: Spillner
authors.forename: M
authors.initials: M
authors.lastname: Schindler
authors.forename: F D
authors.initials: FD
authors.lastname: Daschner
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D006348:Cardiac Surgical Procedures; D002442:Ceftazidime / Q000378:metabolism*; D005260:Female; D006351:Heart Valves / Q000378:metabolism*; D006801:Humans; D008297:Male; D009132:Muscles / Q000378:metabolism*; D011292:Premedication; D014018:Tissue Distribution
chemical_list: D002442:Ceftazidime