[6 beta-hydroxycortisol: a non-invasive reflection of enzymes of drug metabolism].
6-beta-hydroxycortisol (6-beta-OHF) is the main unconjugated metabolite of cortisol in human urine. 6-beta-OHF could be assayed in urine by several methods : chromatography followed by colour reaction, high performance liquid chromatography, radioimmunoassay and enzyme immunoassay. Urinary 6-beta-OHF is increased in some physiological conditions (such as pregnancy) and pathological states (such as hypercortisolemia and liver disease). The measurement of 6-beta-OHF in human urine may provide a useful index of enzyme induction, its excretion being enhanced by many inducers of the mixed function oxygenase.
Zhiri
A
A
Centre de Médecine Préventive, Vandoeuvre-les-Nancy, France.
Wellman-Bednawska
M
M
Siest
G
G
D004790:Enzyme Induction; D004794:Enzyme Repression; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000652:urine; D008099:Liver / Q000201:enzymology*; D010105:Oxygenases / Q000096:biosynthesis; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D004364:Pharmaceutical Preparations; C001380:6 beta-hydroxycortisol; D010105:Oxygenases; D006854:Hydrocortisone
Le 6-beta-hydroxycortisol: un reflet non invasif des enzymes du métabolisme des médicaments.