Bone marrow transplantation for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.
We report the treatment outcome of allogeneic bone marrow transplantation in ten patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Six patients are alive and well for 6 to 30 months (median 19 months) after transplantation. Four patients died with transplant related complications. In view of the poor prognosis associated with this disease, marrow ablation followed by allogeneic or syngeneic marrow grafting may be the preferred treatment modality if a suitable marrow donor is available.
Forman
S J
SJ
O'Donnell
M R
MR
Nademanee
A P
AP
Snyder
D S
DS
Bierman
P J
PJ
Schmidt
G M
GM
Fahey
J L
JL
Stein
A S
AS
Parker
P M
PM
Blume
K G
KG
D000208:Acute Disease; D016026:Bone Marrow Transplantation; D006086:Graft vs Host Disease / Q000473:pathology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000628:therapy; D010677:Philadelphia Chromosome; D011183:Postoperative Complications