title: Drug-receptor relationships, selection of therapeutic goals, and adaptive control of pharmacokinetic systems.
abstract: Drug-receptor relationships are governed by a host of environmental and physiological influences, which reduce the predictability of the therapeutic response to an administered dose of a drug. The management of patient therapy is aided by models that encompass the broadest aspects of the situation, from the probabilistic aspects of drug administration to the accuracy of the assay procedures for evaluating therapeutic efficacy.
authors.forename: R W
authors.initials: RW
authors.lastname: Jelliffe
mesh_terms: D000617:Aminoglycosides / Q000627:therapeutic use; D002302:Cardiac Output / Q000187:drug effects; D003198:Computer Simulation; D003404:Creatinine / Q000097:blood; D004077:Digoxin / Q000627:therapeutic use; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D007700:Kinetics; D008012:Lidocaine / Q000627:therapeutic use; D008954:Models, Biological; D011802:Quinidine / Q000627:therapeutic use; D011955:Receptors, Drug / Q000502:physiology*
chemical_list: D000617:Aminoglycosides; D005839:Gentamicins; D011955:Receptors, Drug; D004077:Digoxin; D008012:Lidocaine; D003404:Creatinine; D011802:Quinidine