title: Erythrocyte repopulation after allogeneic bone marrow transplantation. Analysis using erythrocyte antigens.
abstract: Blood samples from 31 of 50 consecutive patients receiving bone marrow from an HLA-identical and mixed lymphocyte culture-nonreactive sibling were investigated for the presence of donor and autologous erythrocytes. Simple serological techniques using antigenic differences between donor and recipient and a blood transfusion policy taking these differences into account made this study possible. A total of 71% of the patients had donor erythrocytes demonstrable 4 weeks after bone marrow transplantation; almost all patients did so after 2 months. Disappearance or absence of donor red cells indicated poor patient prognosis. Persistence or reappearance of autologous erythrocytes in small percentages (0.05-10%) occurred without relapse of leukemia. Reappearance in high percentage (50-100%) indicated relapse.
authors.affiliation: Blood Transfusion Service, St. Radboud University Hospital, Nijmegen, The Netherlands.
authors.forename: B A
authors.initials: BA
authors.lastname: van Dijk
authors.forename: A M
authors.initials: AM
authors.lastname: Drenthe-Schonk
authors.forename: A
authors.initials: A
authors.lastname: Bloo
authors.forename: V A
authors.initials: VA
authors.lastname: Kunst
authors.forename: J T
authors.initials: JT
authors.lastname: Janssen
authors.forename: T J
authors.initials: TJ
authors.lastname: de Witte
mesh_terms: D000943:Antigens, Differentiation / Q000032:analysis*; D016026:Bone Marrow Transplantation; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D011379:Prognosis; D013997:Time Factors; D014019:Tissue Donors; D014184:Transplantation, Homologous
chemical_list: D000943:Antigens, Differentiation