[Features of mimicry in Plasmodium falciparum].
In this study, we aim to show, by comparing the amino-acid sequences of several antigens of Plasmodium falciparum with those of some proteins manufactured by the host immune system, that the parasite appears to have a remarkable capacity for mimicry. This would help greatly to reduce the efficiency of the immune response during its asexual cycle. Indeed, the major sporozoite surface protein (CSP) has amino-acid sequences in common with interleukin 1; homologies between Pf 11, expressed at the trophozoite stage, and thymosin alpha 1 may be found. Lastly, RESA present at the schizont stage and protein S liberated when the parasitized erythrocyte is lysed, have sequences in common, respectively with thymosin alpha 1 and thymulin.
Bayard
P
P
Laboratoire de Parasitologie Expérimentale, Faculté de Médecine, Pitié-Salpêtrière, Paris.
Monjour
L
L
D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan; D000954:Antigens, Surface; D007375:Interleukin-1; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins; D000077596:Thymalfasin; D013947:Thymosin / Q000031:analogs & derivatives
D000953:Antigens, Protozoan; D000954:Antigens, Surface; D007375:Interleukin-1; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan; D013947:Thymosin; D000077596:Thymalfasin
Traits de mimétisme de Plasmodium falciparum.