title: Overview of current status and future direction of clinical trials with 5-fluorouracil in combination with folinic acid.
authors.affiliation: Investigational Drug Branch, National Cancer Institute, Bethesda, MD 20892.
authors.forename: J L
authors.initials: JL
authors.lastname: Grem
authors.forename: D F
authors.initials: DF
authors.lastname: Hoth
authors.forename: J M
authors.initials: JM
authors.lastname: Hamilton
authors.forename: S A
authors.initials: SA
authors.lastname: King
authors.forename: B
authors.initials: B
authors.lastname: Leyland-Jones
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000188:drug therapy; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects; D005544:Forecasting; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D012004:Rectal Neoplasms / Q000188:drug therapy
chemical_list: D002955:Leucovorin; D005472:Fluorouracil