title: Humoral immunodeficiency: a review.
abstract: Humoral immunodeficiency is a heterogeneous group of rare disorders. The availability of IVGG has meant significant improvement for many patients, but infections continue to occur even on Ig replacement therapy. This may be partially due to associated T cell defects, the inability of current therapy to provide antibody effectively to mucosal surfaces, or the difficulty of providing antibody of sufficiently high titer, affinity, or specificity during infection. A combination of maintenance Ig replacement coupled with increased amounts of Ig and appropriate antibiotics during specific infections remain the mainstays of current therapy.
authors.forename: J M
authors.initials: JM
authors.lastname: Hassett
mesh_terms: D000361:Agammaglobulinemia / Q000235:genetics; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology; D017098:IgA Deficiency; D007116:Immunization, Passive; D007075:Immunoglobulin M; D007136:Immunoglobulins / Q000172:deficiency; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D007223:Infant
chemical_list: D007075:Immunoglobulin M; D007136:Immunoglobulins