title: Does regular treatment with ketotifen inhibit bronchoconstriction induced by isocapnic hyperventilation?
abstract: Eight asthmatic patients completed a 12-week, double-blind, placebo controlled study to assess the efficacy of ketotifen, 1 mg twice daily, in the inhibition of bronchoconstriction induced by isocapnic hyperventilation (IH). There was no significant difference in the degree of bronchoconstriction produced by IH after treatment with ketotifen or placebo.
authors.forename: P
authors.initials: P
authors.lastname: Rafferty
authors.forename: P M
authors.initials: PM
authors.lastname: Tweeddale
authors.forename: R J
authors.initials: RJ
authors.lastname: Ferguson
authors.forename: B A
authors.initials: BA
authors.lastname: Biggs
authors.forename: I W
authors.initials: IW
authors.lastname: Grant
mesh_terms: D000328:Adult; D001249:Asthma / Q000150:complications / Q000188:drug therapy*; D001986:Bronchial Spasm / Q000209:etiology / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D006985:Hyperventilation / Q000150:complications / Q000503:physiopathology*; D007665:Ketotifen / Q000494:pharmacology*; D008297:Male; D011897:Random Allocation
chemical_list: D007665:Ketotifen