title: Pulmonary "cyclosporinoma" mimicking infection after heart transplantation.
abstract: Tissue from a transthoracic needle biopsy, which was performed as part of the investigation of an undiagnosed left upper lobe opacity in a patient after orthotopic heart transplantation, revealed numerous macrophages loaded with oil globules. No causative organisms were present. High-pressure liquid chromatography showed a similar profile to the oil in which cyclosporine is suspended. The lesion appears to have been caused by aspiration of cyclosporine.
authors.affiliation: Department of Cardiothoracic Surgery, University of Newcastle upon Tyne, England.
authors.forename: K
authors.initials: K
authors.lastname: Gould
authors.forename: R
authors.initials: R
authors.lastname: Freeman
authors.forename: N J
authors.initials: NJ
authors.lastname: Odom
authors.forename: T J
authors.initials: TJ
authors.lastname: Locke
authors.forename: C G
authors.initials: CG
authors.lastname: McGregor
mesh_terms: D000328:Adult; D003524:Cyclosporins / Q000009:adverse effects*; D003937:Diagnosis, Differential; D016027:Heart Transplantation; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging; D008297:Male; D011015:Pneumonia, Aspiration / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D011183:Postoperative Complications / Q000139:chemically induced*; D011859:Radiography
chemical_list: D003524:Cyclosporins