Synthetic peptide vaccine confers protection against murine malaria.
A synthetic peptide, (DPPPPNPN)2D, representing a subunit of the repeat domain of the Plasmodium berghei circumsporozoite protein, was conjugated to tetanus toxoid using bisdiazobenzidine. Immunization of mice and rats with the conjugate induced high serum titers of antibodies to the parasite, and most of the animals were completely protected from malaria infection when challenged with sporozoites.
Zavala
F
F
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York 10016.
Tam
J P
JP
Barr
P J
PJ
Romero
P J
PJ
Ley
V
V
Nussenzweig
R S
RS
Nussenzweig
V
V
D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis* / Q000276:immunology; D000915:Antibody Affinity; D000953:Antigens, Protozoan / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D007114:Immunization; D008288:Malaria / Q000517:prevention & control*; D051379:Mice; D008805:Mice, Inbred A; D010455:Peptides / Q000276:immunology; D010962:Plasmodium berghei / Q000276:immunology*; D015800:Protozoan Proteins; D051381:Rats; D011914:Rats, Inbred BN; D013745:Tetanus Toxoid / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology*
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D000954:Antigens, Surface; D010455:Peptides; D015800:Protozoan Proteins; D013745:Tetanus Toxoid; D014614:Vaccines, Synthetic; C041595:circumsporozoite protein, Protozoan