title: Free drug monitoring.
abstract: The principles, technique of measurement, and clinical significance of free drugs are reviewed. Albumin, alpha-1-acid glycoprotein, and lipoprotein are the main drug-binding proteins in blood. Variations of the concentrations of these proteins owing to disease would result in changes in the free drug levels. These levels may be determined by equilibrium dialysis, ultrafiltration, and other techniques.
authors.forename: S
authors.initials: S
authors.lastname: Chan
authors.forename: B
authors.initials: B
authors.lastname: Gerson
mesh_terms: D001798:Blood Proteins / Q000378:metabolism; D006801:Humans; D008991:Monitoring, Physiologic; D004364:Pharmaceutical Preparations / Q000097:blood*; D011485:Protein Binding
chemical_list: D001798:Blood Proteins; D004364:Pharmaceutical Preparations