[Role of growth factors and insulin during pregnancy].
Growth factors represent different classes of polypeptides with insulin-like and mitogenic properties, known to stimulate cellular growth and metabolism. During pregnancy, insulin, insulin-like growth factors (IGFs), EGF, and PDGF are more specifically involved in the development of the fetoplacental unit. These peptides have specific receptors in the placenta and in various fetal tissues, which initiate metabolic and mitogenic effects. In addition, the placenta plays an active part in the regulation of IGFs secretion throughout pregnancy. Several lines of evidence suggest that growth-factors would be active to enhance the proliferative phase of feto-placental growth (14-24 semaines) while insulin would rather stimulate latter metabolic events (30-40 semaines).
Hauguel de Mouzon
S
S
Centre de recherche sur la Nutrition du CNRS, Meudon-Bellevue.
D000653:Amniotic Fluid / Q000378:metabolism; D005314:Embryonic and Fetal Development; D004815:Epidermal Growth Factor / Q000502:physiology; D005260:Female; D005333:Fetus / Q000378:metabolism; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D007335:Insulin-Like Growth Factor II / Q000502:physiology; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D011247:Pregnancy; D011986:Receptors, Somatotropin / Q000032:analysis
D006133:Growth Substances; D007328:Insulin; D010982:Platelet-Derived Growth Factor; D011986:Receptors, Somatotropin; D004815:Epidermal Growth Factor; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II
Rôle des facteurs de croissance et de l'insuline pendant la grossesse.