title: Preliminary clinical trial of immunotherapy for malignant glioma.
abstract: An immunotherapy protocol based on intracranial implantation of stimulated, autologous lymphocytes into the tumor bed following surgical debulking of malignant glioma is described. Phase I clinical trials in human patients are now in progress. Preliminary data representing the first 39 patients treated are presented briefly.
authors.affiliation: Experimental and Clinical Immunotherapy Laboratory, Huntington Medical Research Institutes, Pasadena, CA 91101.
authors.forename: M
authors.initials: M
authors.lastname: Ingram
authors.forename: C H
authors.initials: CH
authors.lastname: Shelden
authors.forename: S
authors.initials: S
authors.lastname: Jacques
authors.forename: R G
authors.initials: RG
authors.lastname: Skillen
authors.forename: W G
authors.initials: WG
authors.lastname: Bradley
authors.forename: G B
authors.initials: GB
authors.lastname: Techy
authors.forename: D B
authors.initials: DB
authors.lastname: Freshwater
authors.forename: R M
authors.initials: RM
authors.lastname: Abts
authors.forename: R W
authors.initials: RW
authors.lastname: Rand
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000628:therapy*; D002986:Clinical Trials as Topic; D005260:Female; D005910:Glioma / Q000628:therapy*; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D007376:Interleukin-2 / Q000494:pharmacology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D007376:Interleukin-2