title: Intracellular Ca2+ in pancreatic acinar cells: regulation and role in stimulation of enzyme secretion.
abstract: Evidence for a primary role for intracellular Ca2+ in the stimulation of pancreatic enzyme secretion is reviewed. Measurements of cytoplasmic free Ca2+ concentration have allowed direct demonstration of its importance in triggering enzyme secretion and defined the concentration range over which membrane Ca2+ pumps must work to regulate intracellular Ca2+. Current evidence suggests a key role for the Ca2+, Mg-ATPase of rough endoplasmic reticulum in regulating intracellular Ca2+ and accumulating a Ca2+ store which is released by the action of inositol-1,4,5 trisphosphate following stimulation of secretion.
authors.affiliation: Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK.
authors.forename: R L
authors.initials: RL
authors.lastname: Dormer
authors.forename: G R
authors.initials: GR
authors.lastname: Brown
authors.forename: C
authors.initials: C
authors.lastname: Doughney
authors.forename: M A
authors.initials: MA
authors.lastname: McPherson
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D005089:Exocytosis; D010179:Pancreas / Q000166:cytology / Q000201:enzymology*
chemical_list: D002118:Calcium