title: The role of mononuclear cell products as modulators of cartilage degradation.
abstract: Human articular cartilage cultured in the presence of interleukin 1 (IL-1) produced from activated peripheral blood mononuclear cells, exhibits the concomitant release of a latent metalloproteinase and fragments of proteoglycan. The manner in which the activated form of the metalloproteinase degrades proteoglycan subunit and link protein suggests a role for this enzyme in cartilage degradation in vivo. While cartilage cultured in the continuous presence of purified IL-1 shows sustained release of metalloproteinase, tissue cultured in the presence of the total products released by activated mononuclear cells from some individuals showed initial stimulation followed by a decline, suggesting the presence of a modulator of IL-1 action.
authors.forename: J S
authors.initials: JS
authors.lastname: Mort
authors.forename: I K
authors.initials: IK
authors.lastname: Campbell
authors.forename: A
authors.initials: A
authors.lastname: Guttman
authors.forename: E E
authors.initials: EE
authors.lastname: Golds
authors.forename: P J
authors.initials: PJ
authors.lastname: Roughley
mesh_terms: D002358:Cartilage, Articular / Q000187:drug effects / Q000378:metabolism*; D046508:Culture Techniques; D010450:Endopeptidases / Q000378:metabolism; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*; D008666:Metalloendopeptidases; D011509:Proteoglycans / Q000378:metabolism
chemical_list: D007375:Interleukin-1; D011509:Proteoglycans; D010450:Endopeptidases; D008666:Metalloendopeptidases