[One-dose treatment of male gonococcal urethritis by ofloxacin].
Ofloxacin is a new fluoroquinolone with excellent in vitro activity against N. gonorrhoeae. 32 adult males with acute uncomplicated gonococcal urethritis were treated with a single-dose of orally administered ofloxacin (400 mg). 1 out of 32 isolates was penicillinase-producing N. gonorrhoeae. Urethral cultures were obtained before treatment and on day 3-5. Microbiological cure was achieved in all patients (100%). No side effects were observed. According to these results, single-dose ofloxacin therapy (400 mg) is effective and safe against uncomplicated gonococcal urethritis in adult males.
Morel
P
P
Lassau
F
F
Casin
I
I
Baury
A
A
Perol
Y
Y
D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D015242:Ofloxacin; D010078:Oxazines / Q000627:therapeutic use*; D014526:Urethritis / Q000188:drug therapy*
D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin
Traitement minute des urétrites masculines gonococciques par l'ofloxacine.