title: Helium pressure potentiates the N-methyl-D-aspartate- and D,L-homocysteate-induced decreases of field potentials in the rat hippocampal slice preparation.
abstract: We examined the influence of helium pressure on the depression induced by various excitatory amino acids in CA1 hippocampal field potentials. The effects of quisqualate, L-glutamate, L-aspartate and kainate were not significantly affected by helium pressure, while those of N-methyl-D-aspartate and D,L-homocysteate were enhanced. These findings suggest that helium pressure specifically increased the sensitivity of the N-methyl-D-aspartate receptor type in the hippocampus. Other hypotheses are discussed.
authors.affiliation: GS de Physiologie Hyperbare C.N.R.S., Faculté de Médecine Nord, Marseille, France.
authors.forename: L
authors.initials: L
authors.lastname: Fagni
authors.forename: F
authors.initials: F
authors.lastname: Zinebi
authors.forename: M
authors.initials: M
authors.lastname: Hugon
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000399:Air Pressure; D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D006371:Helium / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D006710:Homocysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D016202:N-Methylaspartate; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000596:Amino Acids; D006710:Homocysteine; C007956:homocysteic acid; D006371:Helium; D001224:Aspartic Acid; D016202:N-Methylaspartate