title: Diagnosis of pre-type I diabetes.
abstract: Islet cell antibodies were found in 71 of 1169 first-degree relatives (6.1%) from 448 families who had a proband with type I diabetes. Seven children have since become insulin dependent. All had islet cell antibodies and were followed up prospectively with measurement of first-phase insulin production during intravenous glucose tolerance testing. In this group the statistical probability of developing type I diabetes within 12 months with 95% confidence was found to be 59% to 100% when the first-phase insulin secretion was less than 25 microU/mL. The identification of the prediabetes time period should allow an opportunity for intervention in the underlying disease process to determine if the onset of type I diabetes can be altered.
authors.affiliation: Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262.
authors.forename: H P
authors.initials: HP
authors.lastname: Chase
authors.forename: M A
authors.initials: MA
authors.lastname: Voss
authors.forename: N
authors.initials: N
authors.lastname: Butler-Simon
authors.forename: S
authors.initials: S
authors.lastname: Hoops
authors.forename: D
authors.initials: D
authors.lastname: O'Brien
authors.forename: M J
authors.initials: MJ
authors.lastname: Dobersen
mesh_terms: D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D011236:Prediabetic State / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D011446:Prospective Studies
chemical_list: D000906:Antibodies