[50 years of phalloidine: its discovery, characterization and current and future applications in cell research].
Phalloidin, like the later-detected phallotoxins, consists of a cyclic heptapeptide backbone, the ring being crosslinked by a 2'-indolylthioether moiety (tryptathionine). After intraperitoneal administration--not per os--it will, after a short time, damage the liver specifically, presumably in consequence of its very tight binding to F-actin preventing its dissociation. This affinity can be utilized for a sensitive visual identification of F-actin by using fluorescent derivatives.
Wieland
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Max-Planck-Institut für medizinische, Heidelberg.
D000199:Actins / Q000378:metabolism; D000818:Animals; D008099:Liver / Q000187:drug effects / Q000473:pathology; D009842:Oligopeptides / Q000302:isolation & purification / Q000633:toxicity; D010590:Phalloidine / Q000302:isolation & purification / Q000633:toxicity
D000199:Actins; D009842:Oligopeptides; D010590:Phalloidine
50 Jahre Phalloidin. Seine Entdeckung, Charakterisierung sowie gegenwärtige und zukünftige Anwendung in der Zellforschung.