A review of major histocompatibility complex-disease associations in man and dog.
The organization and biology of the Major Histocompatibility Complexes (MHC) of man (HLA) and dog (DLA) are reviewed, and a summary is presented of laboratory techniques used to define allotypes. The nomenclature of this field and the mechanisms of disease association with the MHC are discussed. Currently recognized HLA-disease associations are enumerated, with emphasis on the value of the complement C4 marker. DLA-disease association studies into autoimmune disease, allergy and neoplasia are reviewed.
Day
M J
MJ
Penhale
W J
WJ
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology / Q000662:veterinary; D003181:Complement C4 / Q000032:analysis / Q000235:genetics; D004283:Dog Diseases / Q000235:genetics / Q000276:immunology*; D004285:Dogs / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics; D006649:Histocompatibility Antigens / Q000235:genetics; D006801:Humans; D007154:Immune System Diseases / Q000235:genetics / Q000276:immunology* / Q000662:veterinary; D007126:Immunoglobulin Allotypes / Q000032:analysis; D008285:Major Histocompatibility Complex
D003181:Complement C4; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D007126:Immunoglobulin Allotypes