Implications of the neglect of stereochemistry in pharmacokinetics and clinical pharmacology.
An outline is given of the implications of stereoselectivity in biological action and the use of racemic fixed-ratio combinations in pharmacology and pharmacotherapeutics. Pitfalls of the neglect of stereochemistry, such as generation of senseless pharmacokinetic data, are exemplified and emphasized.
Ariëns
E J
EJ
Institute of Pharmacology and Toxicology, University of Nijmegen, The Netherlands.
D055598:Chemical Phenomena; D002621:Chemistry; D008968:Molecular Conformation; D010599:Pharmacokinetics; D010601:Pharmacology, Clinical; D013237:Stereoisomerism