title: HLA-DR antigen expression on T cells from cerebrospinal fluid in multiple sclerosis and aseptic meningo-encephalitis.
abstract: HLA-DR expression on T lymphocytes in cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) and acute aseptic meningo-encephalitis (AM), and from blood only from healthy controls was examined by a new double-immunofluorescence labelling assay using species-specific second layers on prefixed cell samples. Thirteen of 16 patients with AM (81%) had an elevated percentage of DR positive T cells in CSF against only two of 20 patients with MS (10%). Our data indicate that AM, an acute infection of the central nervous system (CNS), is accompanied by accumulation in CSF of activated, DR positive T cells as a reflection of actively involved cellular immunity within the CNS, while this accumulation of DR positive T cells is not seen in MS, a chronic inflammatory CNS disease, despite some of the patients being examined during clinical exacerbations.
authors.affiliation: Department of Neurology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Fredrikson
authors.forename: A
authors.initials: A
authors.lastname: Karlsson-Parra
authors.forename: T
authors.initials: T
authors.lastname: Olsson
authors.forename: H
authors.initials: H
authors.lastname: Link
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D005455:Fluorescent Antibody Technique; D006681:HLA-D Antigens / Q000134:cerebrospinal fluid*; D006684:HLA-DR Antigens / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid / Q000276:immunology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D006681:HLA-D Antigens; D006684:HLA-DR Antigens