Mobilization of different pools of glucose-incorporated calcium in pancreatic beta-cells after muscarinic receptor activation.
Muscarinic receptor activation resulted in a biphasic mobilization of Ca2+ from isolated pancreatic islets. Glucose was essential for preparing the beta-cells to respond with the initial stimulatory phase. This effect seems to depend on the ability of the sugar to promote active sequestration of Ca2+ in the endoplasmic reticulum.
Hellman
B
B
Gylfe
E
E
Bergsten
P
P
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002217:Carbachol / Q000494:pharmacology; D002460:Cell Line; D002463:Cell Membrane Permeability; D005947:Glucose / Q000494:pharmacology*; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D051379:Mice; D008820:Mice, Obese; D008954:Models, Biological; D051381:Rats; D011976:Receptors, Muscarinic / Q000502:physiology*
D011976:Receptors, Muscarinic; D000255:Adenosine Triphosphate; D002217:Carbachol; D005947:Glucose; D002118:Calcium