Which RBE for iodine 125 in clinical applications?
The problem of the selection of a RBE value for 125I is discussed for clinical applications in interstitial therapy. Microdosimetric studies indicate that the emission of the 125I has a y spectra similar to X-rays of 12-140 keV (conventional X-rays), but differs from 60Co, 137Cs gamma-rays and high energy X-rays. The radiobiological data available show RBE values ranging from 1 to 2.4 for 125I (reference beam 60Co). Although obtained with different biological systems and endpoints, RBE values of 1.15-1.20 are in general observed for high doses and high dose rates. On the other hand, higher RBE values (up to 2) are observed at low doses or low dose rates, which is consistent with theoretical and microdosimetric data.
Scalliet
P
P
Wambersie
A
A
D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D009369:Neoplasms / Q000532:radiotherapy; D009374:Neoplasms, Experimental / Q000532:radiotherapy; D011879:Radiotherapy Dosage; D012062:Relative Biological Effectiveness
D007457:Iodine Radioisotopes