[Effects of beta-lactamases on the antibacterial activity of carumonam and aztreonam against Klebsiella sp. in comparison with 4 other beta-lactams].
Carumonam and aztreonam are two similar monocyclic beta lactam antibiotics. We have studied their antibacterial activities on Klebsiella, in comparison with cefotaxime, cefoxitin, cefotetan and imipenem. In the case of K. pneumoniae (53 strains) the antibacterial activities of the two monobactams are very similar. On the contrary, with K. oxytoca (22 strains) carumonam is significantly more active. This situation seems to be justified by an improved stability of carumonam to beta lactamases. In addition, the antibacterial activities of imipenem and of cephamycins remain quite constant within all the strains. Then the antibacterial activity of cefotaxime is fluctuant, which is in relation with a clear susceptibility to the Klebsiella beta lactamases.
Labia
R
R
Muséum d'Histoire Naturelle, UA 401 CNRS, Paris.
Morand
A
A
Pitton
J S
JS
Philippin
J L
JL
Fournier
P
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001398:Aztreonam / Q000494:pharmacology* / Q000031:analogs & derivatives; D002439:Cefotaxime / Q000494:pharmacology; D015313:Cefotetan; D002440:Cefoxitin / Q000494:pharmacology; D002513:Cephamycins / Q000494:pharmacology; D015378:Imipenem; D007709:Klebsiella / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D007711:Klebsiella pneumoniae / Q000187:drug effects; D010957:Plasmids; D013845:Thienamycins / Q000494:pharmacology; D001618:beta-Lactamases / Q000032:analysis*
D000900:Anti-Bacterial Agents; D002513:Cephamycins; D013845:Thienamycins; C044145:carumonam; D015313:Cefotetan; D002440:Cefoxitin; D015378:Imipenem; D001618:beta-Lactamases; D001398:Aztreonam; D002439:Cefotaxime
Incidence des bêtalactamases sur l'activité antibactérienne du carumonam et de l'aztréonam chez Klebsiella sp en comparaison avec quatre autres bêtalactamines.