Chloramphenicol and vancomycin.
These two antibiotics have been important agents in the treatment of serious infections. Chloramphenicol use is decreasing owing to the potentially fatal toxicities associated with its use. Vancomycin use, on the other hand, is increasing owing to the emergence of methicillin-resistant staphylococci. It is important to routinely monitor serum concentrations of these drugs. An overview of the pharmacology and methods of analysis for each drug is presented in this review.
Miceli
J N
JN
Department of Pharmacology and Medicine, Morehouse School of Medicine, Atlanta, Georgia.
D002701:Chloramphenicol / Q000097:blood* / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D008991:Monitoring, Physiologic / Q000379:methods; D014640:Vancomycin / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use
D002701:Chloramphenicol; D014640:Vancomycin