[Action of a yeast dsRNA preparation on the humoral immune response and the delayed hypersensitivity reaction].
The studies showed that yeast dsRNA in a dose of 2.5 mg/kg had a stimulating effect on the humoral immune response. When the preparation was administered soon after sensitization of experimental animals by the thymus-dependent antigen (sheep red blood cells, SRBC), there were observed a more than two-fold increase in the AFC count in the spleen and increased titers of hemolysins in blood serum. With the use of higher doses of the preparation (up to 10 mg/kg) the level of the immunostimulating effect remained unchanged. The efficacy of the preparation in CBA and C57BL/6 mice with high and low reactivity to the antigen was the same. Delayed-type hypersensitivity in the animals sensitized by SRBC was inhibited by yeast dsRNA in a dose of 10 mg/kg.
Razvorotnev
V A
VA
Sysoeva
G M
GM
Fadina
V A
VA
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization / Q000379:methods; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012330:RNA, Double-Stranded / Q000494:pharmacology*; D012331:RNA, Fungal / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D012330:RNA, Double-Stranded; D012331:RNA, Fungal
Issledovanie deĭstviia preparata drozhzhevoĭ dsRNK na gumoral'nyĭ immunnyĭ otvet i reaktsiiu giperchuvstvitel'nosti zamedlennogo tipa.