title: Continuous positive airway pressure improves the quality of sleep and oxygenation in obstructive sleep apnea syndrome.
abstract: We tested the effects of continuous positive airway pressure (CPAP) in 8 patients with obstructive sleep apnea syndrome (OSAS). The comparison of a nocturnal polygraphic study performed during spontaneous breathing with a study during CPAP administration performed the following night showed a significant reduction in stage 1 and increase in REM, the abolition of obstructive apneas and a significant increase in mean oxyhemoglobin saturation. Most patients reported marked relief of symptoms after the first night of treatment. However 3 patients, though confirming the improvement refused further CPAP. We conclude that CPAP is an effective measure for prevention of apneas in OSAS and that in compliant patients it may be regarded as a short-term measure when a permanent correction of the causes is planned, or as a long-term treatment when the latter is not feasible.
authors.forename: G
authors.initials: G
authors.lastname: Bonsignore
authors.forename: O
authors.initials: O
authors.lastname: Marrone
authors.forename: V
authors.initials: V
authors.lastname: Bellia
authors.forename: G
authors.initials: G
authors.lastname: Giannone
authors.forename: G
authors.initials: G
authors.lastname: Ferrara
authors.forename: F
authors.initials: F
authors.lastname: Milone
mesh_terms: D000368:Aged; D000402:Airway Obstruction / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000378:metabolism; D010349:Patient Compliance; D011175:Positive-Pressure Respiration; D012891:Sleep Apnea Syndromes / Q000097:blood / Q000628:therapy*; D012894:Sleep Stages / Q000502:physiology*
chemical_list: D010108:Oxyhemoglobins; D010100:Oxygen