A double-masked study of timolol and pilocarpine combined.
In a double-masked, randomized, multicenter study, 25 patients received timolol 0.5%-pilocarpine 2% twice a day, 25 received timolol 0.5%-pilocarpine 4% twice a day, and 25 received pilocarpine 4% four times a day. The combination drugs showed an immediate, significant reduction in intraocular pressure of 7.2 mm Hg (25%) and 10.7 mm Hg (37%), respectively. The lowered intraocular pressure level was maintained throughout the three-week test period. With pilocarpine alone, intraocular pressure was reduced 5.3 mm Hg (19%). The mean intraocular pressure 12 hours after the last dose compared to two hours after the last dose was significantly higher both in patients receiving pilocarpine four times a day and in patients receiving timolol 0.5%-pilocarpine 4% twice a day (5.1 and 3.6 mm Hg, respectively), but not in patients receiving timolol 0.5%-pilocarpine 2% twice a day (2.6 mm Hg).
Airaksinen
P J
PJ
Department of Ophthalmology, University of Oulu, Finland.
Valkonen
R
R
Stenborg
T
T
Takki
K
K
Klemetti
A
A
Kontkanen
M
M
Oskala
P
P
D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D010862:Pilocarpine / Q000008:administration & dosage* / Q000627:therapeutic use; D013999:Timolol / Q000008:administration & dosage* / Q000627:therapeutic use
D004338:Drug Combinations; D010862:Pilocarpine; D013999:Timolol