title: Single course versus maintenance bacillus Calmette-Guerin therapy for superficial bladder tumors: a prospective, randomized trial.
abstract: A total of 42 patients with recurrent superficial bladder tumors or carcinoma in situ entered a prospective, randomized trial to compare the efficacy of bacillus Calmette-Guerin therapy with and without quarterly maintenance instillations of bacillus Calmette-Guerin. Maintenance therapy did not reduce further bladder tumor recurrence rates or the interval to recurrence in patients who responded to the initial course of therapy. However, prolongation of toxicity was observed with maintenance bacillus Calmette-Guerin therapy.
authors.forename: M A
authors.initials: MA
authors.lastname: Hudson
authors.forename: T L
authors.initials: TL
authors.lastname: Ratliff
authors.forename: D P
authors.initials: DP
authors.lastname: Gillen
authors.forename: E O
authors.initials: EO
authors.lastname: Haaff
authors.forename: S M
authors.initials: SM
authors.lastname: Dresner
authors.forename: W J
authors.initials: WJ
authors.lastname: Catalona
mesh_terms: D000283:Administration, Intravesical; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002278:Carcinoma in Situ / Q000628:therapy*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D011446:Prospective Studies; D011897:Random Allocation; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000628:therapy*
chemical_list: D001500:BCG Vaccine