Renal amyloidosis in children: an ultrastructural study.
Eleven renal biopsy specimens from 10 children affected with systemic amyloidosis were studied by electron microscopy. Focal parietal deposits of amyloid fibrils and detachment of podocytes were observed in the 9 patients having marked proteinuria. Adjacent capillary loops were normal with intact podocyte foot processes. In the 2 renal biopsies obtained after treatment of the underlying disease a double layer of subendothelial and subepithelial basement membrane material enclosed the parietal amyloid deposits and separated them from adjacent cells.
Gubler
M C
MC
INSERM U.192, Hôpital Necker Enfants-Malades, Paris, France.
Naizot
C
C
D000293:Adolescent; D000686:Amyloidosis / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007668:Kidney / Q000648:ultrastructure*; D007674:Kidney Diseases / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron