Expression of heterophile, Paul-Bunnell and Hanganutziu-Deicher antigens on human melanoma cell lines.
Expression of heterophile antigens was studied on 6 human melanoma cell lines. Paul-Bunnell and Hanganutziu-Deicher (H-D) antigens, but not Forssman antigen, were demonstrated on these cell lines. H-D antigen was also demonstrated on melanoma cells isolated from primary and metastatic lesions. Evidence was also presented that HLA class I but not class II (DR and DQ) molecules are expressed on these cell lines. H-D antibodies of IgG class were detected in 10 of 23 (42%) melanoma patients suggesting the possibility that H-D antigen might have been expressed in an immunogenic form in the patients.
Nakarai
H
H
Saida
T
T
Shibata
Y
Y
Irie
R F
RF
Kano
K
K
D000910:Antibodies, Heterophile / Q000276:immunology; D015478:Antigens, Heterophile / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000032:analysis*; D002460:Cell Line; D005455:Fluorescent Antibody Technique; D005577:Forssman Antigen / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008545:Melanoma / Q000276:immunology*
D000910:Antibodies, Heterophile; D015478:Antigens, Heterophile; D000951:Antigens, Neoplasm; D006680:HLA Antigens; D005577:Forssman Antigen