Analysis of IgA1 and IgA2 subclass distribution in IgA- containing circulating immune complexes in patients with diabetes mellitus.
Immune complexes (IC) containing IgA1 and IgA2 have been detected in diabetes mellitus. In particular IgA1 and IgA2-IC are equally distributed in type 2 diabetes. On the other hands IgA1-IC are prevailingly found in type 1 diabetes mellitus. IgA2-IC (immune complexes of "mucosal" origin?) seen to be of relevance in the pathogenesis of diabetic microangiopathy.
Triolo
G
G
Istituto di Clinica Medica, University of Palermo, Italy.
Giardina
E
E
Seddio
G
G
Terrizzi
C
C
D000936:Antigen-Antibody Complex / Q000032:analysis*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D003925:Diabetic Angiopathies / Q000209:etiology / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D007070:Immunoglobulin A / Q000032:analysis*; D008875:Middle Aged
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A