title: The gerontological decline of the renin-aldosterone system: a chronobiological approach extended to essential hypertension.
abstract: The circadian (about 24-hr) oscillating function of the renin-angiotensin-aldosterone system (RAAS) was investigated as a function of age in clinically healthy participants and in essential hypertensive patients. A peculiar age-related decline in the RAAS circadian mesor (rhythm-adjusted mean) and amplitude (variability from mesor) was found in the essential hypertensive patients. This finding suggests a nonphysiologic evolution in the tonic (24-hr mean level) as well as phasic (oscillating amplitude) circadian activity of the RAAS with increasing age. A relative hyperreninemic aldosteronism characterized the aged essential hypertensive patients.
authors.forename: P
authors.initials: P
authors.lastname: Cugini
authors.forename: G
authors.initials: G
authors.lastname: Murano
authors.forename: P
authors.initials: P
authors.lastname: Lucia
authors.forename: C
authors.initials: C
authors.lastname: Letizia
authors.forename: D
authors.initials: D
authors.lastname: Scavo
authors.forename: F
authors.initials: F
authors.lastname: Halberg
authors.forename: H
authors.initials: H
authors.lastname: Schramm
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D000450:Aldosterone / Q000097:blood; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System
chemical_list: D000450:Aldosterone; D012083:Renin