[Diffusion of fluoroquinolones in the aqueous humor and crystalline lens].
In 53 patients undergoing cataract extraction, the authors measured pefloxacin and ofloxacin penetration in aqueous humour and lens. Cataract removal was performed at varying times after either the end of one-hour infusion of pefloxacin, ofloxacin per os in one time, or pefloxacin per os during 3 days. In the two first schemes, acme concentrations in aqueous humour are 1.45 mg/l for pefloxacin, 1.14 mg/l for ofloxacin. These concentrations reach the MIC90 of most bacteria usually involved in endophthalmia. The steady state concentrations of pefloxacin are between 6 and 7 mg/l during the first 12 h: they reach the MIC of 80% of Streptococci. There is no evidence of accumulation of pefloxacin in lens; lenticular concentrations of ofloxacin are very low and rapidly decrease.
Lafaix
C
C
Service des Maladies Infectieuses, Centre Hospitalier, Villeneuve-Saint-Georges.
Salvanet
A
A
Fisch
A
A
Forestier
F
F
Montay
G
G
Meulemans
A
A
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D004058:Diffusion; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism*; D008875:Middle Aged; D009643:Norfloxacin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D015242:Ofloxacin; D010078:Oxazines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015366:Pefloxacin
D000900:Anti-Bacterial Agents; D010078:Oxazines; D015366:Pefloxacin; D015242:Ofloxacin; D009643:Norfloxacin
Diffusion des fluoroquinolones dans l'humeur aqueuse et le cristallin.