HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.
Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the beta-chain, specifies the autoimmune response against the insulin-producing islet cells.
Todd
J A
JA
Department of Medical Microbiology, Stanford University School of Medicine, California 94305.
Bell
J I
JI
McDevitt
H O
HO
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D002896:Chromosomes, Human, Pair 6; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D004198:Disease Susceptibility; D008040:Genetic Linkage; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D006238:Haploidy; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D007113:Immunity, Innate; D007515:Islets of Langerhans / Q000276:immunology; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000032:analysis; D011110:Polymorphism, Genetic
D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D009841:Oligonucleotides