title: Antibiotic treatment of chronic central venous hemodialysis catheter infection without catheter removal.
abstract: Most catheter or shunt infections in hemodialysis patients require the removal of the access before the infection is eradicated. A hemodialysis patient is reported who had multiple previous vascular accesses which failed and thus who had very limited sites for future access placement. When a recurrent Proteus mirabilis catheter infection occurred, a 6-week course of ampicillin intraluminal and tobramycin systematically, eradicated the infection and thus the central venous catheter was salvaged. Serum bactericidal levels with these two antibiotics were obtained early in the course and supported the continued use of antibiotics alone to treat the infection.
authors.affiliation: Department of Internal Medicine, St. Louis University Medical Center, Missouri.
authors.forename: D T
authors.initials: DT
authors.lastname: Domoto
authors.forename: D J
authors.initials: DJ
authors.lastname: Kennedy
mesh_terms: D000667:Ampicillin / Q000627:therapeutic use*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002408:Catheters, Indwelling / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011512:Proteus Infections / Q000188:drug therapy* / Q000382:microbiology; D011513:Proteus mirabilis; D006435:Renal Dialysis / Q000009:adverse effects*; D014031:Tobramycin / Q000627:therapeutic use*
chemical_list: D000667:Ampicillin; D014031:Tobramycin