title: Novel R-factor borne beta-lactamase of Escherichia coli confering resistance to cephalosporins.
abstract: Strains of Escherichia coli resistant to ceftazidime but susceptible to other third generation cephalosporins were detected in three patients at two different locations (München, Bremen). The resistance was self-transmissible to other E. coli strains. Resistance against ampicillin, kanamycin, chloramphenicol and sulfonamide was co-transferred. The isoelectric point (pI) of the beta-lactamase was similar to the pI of the AER-1 and LCR-1 beta-lactamases. These enzymes, however, do not confer resistance to ceftazidime. Therefore the beta-lactamase described is the first example for a ceftazidimase.
authors.affiliation: Max von Pettenkofer Institute, University of Munich.
authors.forename: A
authors.initials: A
authors.lastname: Bauernfeind
authors.forename: G
authors.initials: G
authors.lastname: Hörl
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002442:Ceftazidime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D003550:Cystic Fibrosis / Q000382:microbiology; D004352:Drug Resistance, Microbial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D005260:Female; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D011014:Pneumonia / Q000382:microbiology; D011815:R Factors; D001618:beta-Lactamases / Q000032:analysis / Q000235:genetics*
chemical_list: D002511:Cephalosporins; D002442:Ceftazidime; D001618:beta-Lactamases