title: [Chlorambucil pulse therapy in progressive chronic polyarthritis. Initial results of an open multicenter study].
abstract: The first preliminary clinical results with chlorambucil pulse-therapy in patients with refractory rheumatoid arthritis are reported, with a dose of chlorambucil below that which might risk inducing leukaemia. The clinical response was good in 15 out of 19 patients; symptoms and objective findings of rheumatoid arthritis had significantly improved. However, multiple toxic reactions have been identified in our patients.
authors.affiliation: Rheumatologische Universitätsklinik Basel, Schweiz.
authors.forename: A
authors.initials: A
authors.lastname: Aeschlimann
authors.forename: D
authors.initials: D
authors.lastname: Brackertz
authors.forename: H
authors.initials: H
authors.lastname: Kaiser
authors.forename: W
authors.initials: W
authors.lastname: Müller
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002699:Chlorambucil / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002699:Chlorambucil
vernacular_title: Chlorambucil-Stosstherapie bei progressiver chronischer Polyarthritis. Erste Ergebnisse einer offenen multizentrischen Studie.