Activity of selected beta-lactam antibiotics against Mycobacterium leprae.
Twelve beta-lactam antibiotics were tested for activity against Mycobacterium leprae growing in the foot pads of mice. Two cephalosporins (7-aminocephalosporanic acid and cefuroxime) and one cephamycin (cefoxitin) showed significant activity against M. leprae, and one penicillin (mezlocillin) exerted possible growth-promoting activity. These results suggest that particular molecular structures may be required for activity against M. leprae.
Shepard
C C
CC
Van Landingham
R M
RM
Walker
L L
LL
Good
R C
RC
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002440:Cefoxitin / Q000494:pharmacology; D002444:Cefuroxime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D005260:Female; D007918:Leprosy / Q000188:drug therapy / Q000382:microbiology; D008802:Mezlocillin / Q000494:pharmacology; D051379:Mice; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000254:growth & development; D010406:Penicillins / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins; D002440:Cefoxitin; C030735:7-aminocephalosporanic acid; D002444:Cefuroxime; D008802:Mezlocillin