Glutamate decarboxylase-like immunoreactive neurons in the rat caudate putamen.
GAD-IR neurons were roughly divided into those with medium sized perikarya and large perikarya. The medium-sized GAD-IR neurons accounted for about 85% of the GAD-IR neurons. The medium-sized perikarya were further divided into two, those with a smooth nuclear membrane and those with an indented nucleus. The former were very similar to medium-sized spiny neurons and the latter corresponded to medium-sized aspiny neurons. The GAD-IR large cells that were identified by light microscopy, had nuclear indentations and were divided into two classes based on their ultrastructural features, type 1 large cells received few synaptic inputs and type 2 large cells received many synaptic contacts from non-immunoreactive or immunoreactive boutons. The former resembles Type I large cells and the latter Type II large cells identified recently by Chang and Kitai; the latter are also similar to the second type of projecting neurons identified by Bolam et al.
Kubota
Y
Y
Inagaki
S
S
Shimada
S
S
Kito
S
S
Wu
J Y
JY
D000818:Animals; D002421:Caudate Nucleus / Q000201:enzymology* / Q000648:ultrastructure; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D011699:Putamen / Q000201:enzymology* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000201:enzymology / Q000648:ultrastructure
D005968:Glutamate Decarboxylase