Genes within the major histocompatibility complex influence the response to ampicillin therapy and severity of relapse in H-2 congenic, susceptible Itys mice infected with virulent Salmonella typhimurium.
Control by genes within H-2 of natural resistance to fully virulent salmonellae in susceptible mice was studied by the typhoid relapse model. Susceptible (Itys), H-2 congenic C57BL/10 (B10) lines were infected with a lethal dose of the virulent S. typhimurium C5 and rescued from death by ampicillin therapy, inducing a chronic infection. The response to therapy and its cessation, both early and late in the infection, varied in different strains. B10 (H-2b) and B10.D2 (H-2d) responded less well to therapy, and were more prone to relapse on its removal, than B10.A (H-2a) or B10.M (H-2f) mice. This haplotype distribution is the same as that previously reported for H-2 linked resistance and susceptibility of similar mice to salmonellae of low virulence. The results indicate that resistance to a virulent salmonella capable of causing natural infection is influenced by genes within the MHC.
Maskell
D J
DJ
Hormaeche
C E
CE
D000667:Ampicillin / Q000627:therapeutic use; D000818:Animals; D005260:Female; D006183:H-2 Antigens / Q000235:genetics*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012481:Salmonella Infections, Animal / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D012486:Salmonella typhimurium
D006183:H-2 Antigens; D000667:Ampicillin