title: B-cell chronic lymphocytic leukaemia with aberrant expression of CD8 antigen.
abstract: The monoclonal antibodies against CD8 (T suppressor/cytotoxic) antigen (Leu2/OKT8) were found to bind to leukaemic lymphocytes from a patient with chronic lymphocytic leukaemia. The cells also had an unusual type of rod-like cytoplasmic immunoglobulin of IgM/lambda type as seen by light, fluorescence and electron microscopy, and displayed several antigens characteristic for B lymphocytes. Gene rearrangement analysis showed rearrangement of mu heavy chain gene. In spite of an expression of CD8 antigen, T-cell receptor genes were not rearranged.
authors.affiliation: Division of Haematology, Karolinska Hospital, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Porwit
authors.forename: L
authors.initials: L
authors.lastname: Borgonovo
authors.forename: E
authors.initials: E
authors.lastname: Osby
authors.forename: R
authors.initials: R
authors.lastname: Lenkei
authors.forename: C I
authors.initials: CI
authors.lastname: Smith
authors.forename: L
authors.initials: L
authors.lastname: Hammarström
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D001345:Autoradiography; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000276:immunology*; D016169:Lymphocyte Function-Associated Antigen-1
chemical_list: D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D016169:Lymphocyte Function-Associated Antigen-1