[Autovaccination in chronic pyelonephritis in the animal experiment--effect of cyclophosphamide on splenic and thymus lymphocytes].
In rats with experimental pyelonephritis, cyclophosphamide leads to changes in the spleen and thymus lymphocyte populations. When cyclophosphamide was given five times a week from the fifth week of infection on, the population of electrophoretically slow moving spleen lymphocytes, which are believed to be B-lymphocytes, decreased in the seventh week. This effect is independent of autovaccination. During the same period the number of immature slow moving thymus lymphocytes decreased. Further treatment with cyclophosphamide until the twelfth week of infection led to the differences almost disappearing in the histogramm. Cyclophosphamide showed a slight effect on antibody production and did not influence the elimination of infective agents from the kidneys of animals with pyelonephritis.
Straube
E
E
Institut für Mikrobiologie des Bereiches Medizin, der Wilhelm-Pieck-Universität Rostock.
Schütt
W
W
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D001428:Bacterial Vaccines / Q000276:immunology*; D002908:Chronic Disease; D003520:Cyclophosphamide / Q000494:pharmacology*; D004926:Escherichia coli / Q000276:immunology; D004927:Escherichia coli Infections / Q000276:immunology*; D022361:Escherichia coli Vaccines; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D011704:Pyelonephritis / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000187:drug effects*
D001428:Bacterial Vaccines; D022361:Escherichia coli Vaccines; D003520:Cyclophosphamide
Autovakzination bei der chronischen Pyelonephritis im Tierversuch--Einfluss von Cyclophosphamid auf Milz- und Thymuslymphozyten.