title: Activity of epomediol in the treatment of hepatopathies: a double-blind multi-centre study.
abstract: A multi-centre study with epomediol discoids (200 mg three times daily for 30 days) versus placebo was carried out in 519 patients either with symptoms attributable to hepatopathy and/or alterations in the hepatic function. Epomediol was given to 257 patients chosen at random and the remaining 262 were given placebo. In cases of hepatopathy in which there was no severe damage to the hepatic parenchyma the symptoms of the disease were reduced and the laboratory parameters were improved on treatment with epomediol, whereas the activity of the drug was low in patients with chronic hepatopathy. This confirms that the clinical use of epomediol is most useful in cases of hepatopathy in which the change in hepatic function is still reversible.
authors.forename: L
authors.initials: L
authors.lastname: Capurso
authors.forename: M
authors.initials: M
authors.lastname: Kock
authors.forename: F
authors.initials: F
authors.lastname: Ferrario
authors.forename: F
authors.initials: F
authors.lastname: Del Sette
authors.forename: C
authors.initials: C
authors.lastname: Gramolini
authors.forename: C L
authors.initials: CL
authors.lastname: Castiglioni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002756:Cholagogues and Choleretics / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004415:Dyspepsia / Q000188:drug therapy; D005260:Female; D006505:Hepatitis / Q000188:drug therapy*; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013729:Terpenes / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D002756:Cholagogues and Choleretics; D013729:Terpenes; C031365:epomediol