Immunomodulatory activity of an aqueous extract of Azadirachta indica stem bark.
The interference of an aqueous extract of the stem bark of Azadirachta indica with different parts of the human immune system was investigated. The extract showed strong anticomplementary effects which were dose-and time-dependent and most pronounced in the classical complement pathway assay. Moreover, a dose-dependent decrease in the chemiluminescence of polymorphonuclear leukocytes was observed and a dose-dependent increase in the production of migration inhibition factor by lymphocytes.
van der Nat
J M
JM
Klerx
J P
JP
van Dijk
H
H
de Silva
K T
KT
Labadie
R P
RP
D000276:Adjuvants, Immunologic; D003171:Complement Pathway, Classical / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis; D008163:Luminescent Measurements; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013188:Sri Lanka
D000276:Adjuvants, Immunologic; D007961:Leukocyte Migration-Inhibitory Factors; D010936:Plant Extracts; D011043:Pokeweed Mitogens