Oxidant-antioxidant balance.
We briefly consider some examples illustrating the pathophysiologic roles of oxidants in lung injury: pathologic changes induced by hyperoxia (exudative alveolar oedema and proliferation of fibroblasts), cell toxicity (especially endothelial cells) and inactivation of alpha-1-proteinase inhibitor (by oxidation of a methionyl residue at the active site of the inhibitor). These suggest the possibility of a beneficial role for antioxidants in many types of lung injury.
Cordier
J F
JF
Université Claude-Bernard, Hôpital Louis-Pradel, Lyon, France.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D005609:Free Radicals; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced* / Q000503:physiopathology; D010100:Oxygen / Q000633:toxicity*; D011480:Protease Inhibitors / Q000494:pharmacology
D000975:Antioxidants; D005609:Free Radicals; D011480:Protease Inhibitors; D010100:Oxygen