Effects of captopril on circulating T lymphocyte subsets.
Six patients treated with captopril for severe essential hypertension were studied to determine whether the drug significantly altered circulating peripheral blood T (Thymus derived) lymphocytes and T lymphocyte subsets. OKT3+ (functionally mature T lymphocytes), OKT4+ (class II major histocompatibility complex [MHC] reactive T lymphocytes) and OKT8+ (class I MHC reactive T lymphocytes) T lymphocytes were monitored using monoclonal antibodies and flow cytometry before commencement of treatment and then at intervals during 14 months of captopril administration. Results showed a significant increase in the absolute numbers of OKT4+ cells at 2 h (p less than 0.05) and a decrease at 12 weeks (p less than 0.01) during captopril treatment. These findings indicate that captopril has an effect on cellular immunity in vivo.
Smart
Y C
YC
Gillies
A H
AH
Waga
S W
SW
Carney
S L
SL
Smith
A J
AJ
Burton
R C
RC
D000368:Aged; D002216:Captopril / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007958:Leukocyte Count / Q000187:drug effects; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000145:classification / Q000187:drug effects*
D002216:Captopril