title: IL 1 and bacterial lipopolysaccharide increase the ability of human endothelial cells to bind peripheral blood monocytes.
abstract: Human endothelial cells (EC) exposed to human recombinant IL 1 and to bacterial lipopolysaccharide (LPS) demonstrated a time dependent increase in their ability to bind peripheral blood monocytes (M0). The enhancement of endothelial-M0 interactions was shown to represent a direct alteration of EC and was not explained by IL 1 and LPS affecting M0. Other experiments indicated that the enhancement represented an acceleration in EC binding of M0 suggesting that EC may play a role in initiating proinflammatory events prior to the recruitment of inflammatory cells by chemotactic peptides.
authors.affiliation: Department of Physiological Chemistry, Ohio State University 43210.
authors.forename: E C
authors.initials: EC
authors.lastname: Downs
authors.forename: D G
authors.initials: DG
authors.lastname: Cornwell
authors.forename: V K
authors.initials: VK
authors.lastname: Proctor
authors.forename: R L
authors.initials: RL
authors.lastname: Whisler
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects*; D002478:Cells, Cultured; D004727:Endothelium / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D007700:Kinetics; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D012486:Salmonella typhimurium
chemical_list: D007375:Interleukin-1; D008070:Lipopolysaccharides