title: [The effect of radio- and chemotherapy on survival in advanced head and neck tumors].
abstract: Inoperable cases of advanced squamous cell carcinomas in the head and neck area which have a very poor prognosis are often treated by a combined radio- and chemotherapy. Tumor remissions up to 70% are induced by both radiotherapy and chemotherapy alone; an increase of the survival time is not reported. The present randomized study investigates the efficacy of two therapy schemes, i.e. chemotherapy alone and chemotherapy combined with irradiation. Tumor remissions of 75% were achieved in 80 evaluable patients, the median remission period was four months and the median survival period eleven months. The survival curves do not show any dependence of the survial time on the size of tumor or metastases. Only responders had a significantly longer survival time than non-responders.
authors.forename: A
authors.initials: A
authors.lastname: Klima
authors.forename: C
authors.initials: C
authors.lastname: von Ilberg
authors.forename: L
authors.initials: L
authors.lastname: Bergmann
authors.forename: T
authors.initials: T
authors.lastname: Klippstein
authors.forename: A
authors.initials: A
authors.lastname: Zoubek
authors.forename: P S
authors.initials: PS
authors.lastname: Mitrou
authors.forename: S
authors.initials: S
authors.lastname: Szepisi
authors.forename: A
authors.initials: A
authors.lastname: Jakobi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000401:mortality* / Q000532:radiotherapy; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000532:radiotherapy; D006801:Humans; D011379:Prognosis; D011897:Random Allocation
vernacular_title: Zur Wirksamkeit von Radio- und Chemotherapie auf die Uberlebenszeit bei fortgeschrittenen Kopf-Hals-Tumoren.