Severe hepatotoxicity from Escherichia coli L-asparaginase.
A 51-year-old black woman with diabetes mellitus developed severe hepatotoxicity after receiving high-dose L-asparaginase (Elspar) for acute lymphatic leukemia. Patients with diabetes should be given this drug cautiously. Glutaminase-free L-asparaginase from Vibrio succinogenes has been reported to be less hepatotoxic in mice; it might be a safer product for this group of patients.
Jenkins
R
R
Perlin
E
E
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001215:Asparaginase / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D004926:Escherichia coli / Q000201:enzymology; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D008875:Middle Aged
D001215:Asparaginase