title: Loss of parvalbumin-immunoreactive neurones from cortex in Alzheimer-type dementia.
abstract: The type and cell size of parvalbumin-immunoreactive (PV-Ir) neurones were examined in 14 postmortem brains from elderly control and Alzheimer-type dementia (ATD) patients with the aid of an image analyser. Morphological features of PV-Ir neurones suggested the existence of PV in the non-pyramidal interneurones in the cerebral cortex. A significant loss of PV-Ir cells was found in the frontal and temporal cortex in ATD. A significant reduction in the size of PV-Ir cells was also noted in the temporal cortex in ATD. These findings suggested that PV-Ir neurones in the cortex are affected in ATD.
authors.affiliation: MRC Group, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, U.K.
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: P C
authors.initials: PC
authors.lastname: Emson
authors.forename: C Q
authors.initials: CQ
authors.lastname: Mountjoy
authors.forename: L H
authors.initials: LH
authors.lastname: Carassco
authors.forename: C W
authors.initials: CW
authors.lastname: Heizmann
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D002452:Cell Count; D002540:Cerebral Cortex / Q000032:analysis* / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D009124:Muscle Proteins / Q000032:analysis*; D010320:Parvalbumins / Q000032:analysis*
chemical_list: D009124:Muscle Proteins; D010320:Parvalbumins