Multiple organ-reactivity of monoclonal autoantibodies to mouse erythrocytes.
Autoantibodies reacting with bromelain-treated autologous mouse red blood cells (Br-MRBC) are spontaneously produced by normal mice. In order to understand the biological significance of these autoantibodies, anti-Br-MRBC monoclonal autoantibodies have been prepared and studied for reactivity with a panel of frozen tissue sections from organs of normal mice by direct immunofluorescence. It has been found that the anti-Br-MRBC monoclonal autoantibodies are polyspecific, since they react with cells in multiple organs.
Garzelli
C
C
Basolo
F
F
Puglisi
C
C
Pacciardi
A
A
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000032:analysis* / Q000276:immunology; D001963:Bromelains / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D005753:Gastric Mucosa / Q000276:immunology; D008221:Lymphoid Tissue / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012469:Salivary Glands / Q000276:immunology; D013737:Testis / Q000276:immunology
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D001324:Autoantigens; D001963:Bromelains