title: Serum antimuscarinic activity after a single dose of oral scopolamine hydrobromide solution measured by radioreceptor assay.
abstract: Radioreceptor assay (RRA) was used to evaluate serum antimuscarinic activity in 10 healthy volunteers after a single dose of scopolamine hydrobromide (ScHBr) solution, 0.02 mg/kg, by a new oral administration method. Cardiac, antisialogogue, and subjective effects of the drug were also recorded. Although clinically useful antisialogogue and sedative effects were obtained 40 to 60 minutes after the administration of ScHBr, no reliable antimuscarinic activity was evaluated in serum samples for up to 3 hours. Clinically useful sedative and antisialogogue effects can be reached by gastrointestinal absorption of ScHBr solution.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Markkanen
authors.forename: L
authors.initials: L
authors.lastname: Laurén
authors.forename: T
authors.initials: T
authors.lastname: Peltomäki
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001285:Atropine / Q000097:blood; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011869:Radioligand Assay; D011897:Random Allocation; D011976:Receptors, Muscarinic / Q000187:drug effects*; D012472:Salivation / Q000187:drug effects; D012601:Scopolamine / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D011976:Receptors, Muscarinic; D001285:Atropine; D012601:Scopolamine