title: Prevention of nephrotoxic cyclosporine peak concentrations by daily drug division in 3 equal oral portions.
abstract: Nephrotoxicity is the main side effect of cyclosporine therapy. In this study 2 groups consisting of 6 kidney transplant recipients were investigated. The oral cyclosporine daily dose was in the first group 13 mg/kg, in the second 11 mg/kg, respectively. In both groups, the daily dose was divided on the first day of investigation in 2 equal portions given at an interval of 12 hours. On the second day, the same dose was divided in 3 equal portions given at an interval of 8 hours. After cyclosporine administration twice a day very high blood cyclosporine peak concentrations (two to three times higher than the therapeutic range) were measured. These potential nephrotoxic cyclosporine concentrations could be prevented by cyclosporine application in 3 equal portions. A reduction of the daily dose in the early period after kidney transplantation to a starting daily dose of 12 mg/kg or even 10 mg/kg can be recommended.
authors.forename: J
authors.initials: J
authors.lastname: Zazgornik
authors.forename: J
authors.initials: J
authors.lastname: Schindler
authors.forename: P
authors.initials: P
authors.lastname: Balcke
authors.forename: H
authors.initials: H
authors.lastname: Kopsa
authors.forename: F
authors.initials: F
authors.lastname: Gremmel
authors.forename: K
authors.initials: K
authors.lastname: Derfler
authors.forename: G
authors.initials: G
authors.lastname: Kretschmer
authors.forename: F
authors.initials: F
authors.lastname: Mühlbacher
authors.forename: F
authors.initials: F
authors.lastname: Piza
mesh_terms: D000328:Adult; D003524:Cyclosporins / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D004334:Drug Administration Schedule; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D016030:Kidney Transplantation; D007700:Kinetics; D008875:Middle Aged
chemical_list: D003524:Cyclosporins