title: Oxidant-antioxidant balance.
abstract: We briefly consider some examples illustrating the pathophysiologic roles of oxidants in lung injury: pathologic changes induced by hyperoxia (exudative alveolar oedema and proliferation of fibroblasts), cell toxicity (especially endothelial cells) and inactivation of alpha-1-proteinase inhibitor (by oxidation of a methionyl residue at the active site of the inhibitor). These suggest the possibility of a beneficial role for antioxidants in many types of lung injury.
authors.affiliation: Université Claude-Bernard, Hôpital Louis-Pradel, Lyon, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Cordier
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D005609:Free Radicals; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced* / Q000503:physiopathology; D010100:Oxygen / Q000633:toxicity*; D011480:Protease Inhibitors / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D011480:Protease Inhibitors; D010100:Oxygen