Clinical significance of glucocorticoid receptors in acute leukaemia. Preliminary observations in Hungary and review of the literature.
Glucocorticoid receptor (GR) levels were quantitated in leukaemic blast cells separated from peripheral blood of 15 children with acute lymphocytic leukaemia (ALL) and of 6 children with acute non-lymphocytic leukaemia (ANLL). Using a whole-cell assay, it was found that specific (3H)-dexamethasone binding exhibited a wide range in both types of acute leukaemia: GR levels scattered between 0-22,346/cell and 0-8772/cell in ALL and ANLL patients, respectively. In this paper we discuss our observations together with current knowledge on GR levels in leukaemic blast cells and their relationship to glucocorticoid sensitivity and disease outcome.
Kiss
C
C
Department of Paediatrics, Debrecen University Medical School, Hungary.
Kovács
I
I
Kerepesi
T
T
Karmazsin
L
L
D000208:Acute Disease; D002648:Child; D006801:Humans; D006814:Hungary; D007938:Leukemia / Q000097:blood*; D007945:Leukemia, Lymphoid / Q000097:blood*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D011379:Prognosis; D011965:Receptors, Glucocorticoid / Q000378:metabolism*
D011965:Receptors, Glucocorticoid