[Evaluation of dipyridamole efficacy as an agent for preventing acute respiratory viral diseases].
The epidemiological effectiveness of a low molecular interferon inducer, dipyridamole, as a means of prevention of influenza and ARD was studied in a double-blind epidemiological trial in a period of seasonal rise of ARD (Dec., 26, 1984-March 13, 1985). A statistically significant decrease of ARD incidence (1.91-fold) in the experimental group was confirmed by the results of serological studies and titrations of serum interferon in paired sera collected before the prevention and 10 days after its termination in selected subgroups from the experimental and control groups. The results indicate that the use of dipyridamole may be effective for mass prevention of influenza and ARD.
Kozhukharova
M S
MS
Slepushkin
A N
AN
Radeva
Kh T
KhT
Lavrukhina
L A
LA
Demidova
S A
SA
D000208:Acute Disease; D000328:Adult; D002031:Bulgaria; D002986:Clinical Trials as Topic; D004176:Dipyridamole / Q000627:therapeutic use*; D004196:Disease Outbreaks / Q000517:prevention & control; D004311:Double-Blind Method; D006801:Humans; D007251:Influenza, Human / Q000517:prevention & control; D007369:Interferon Inducers; D008875:Middle Aged; D010919:Placebos; D012141:Respiratory Tract Infections / Q000517:prevention & control*; D012621:Seasons; D014505:Urban Population; D014777:Virus Diseases / Q000517:prevention & control*
D007369:Interferon Inducers; D010919:Placebos; D004176:Dipyridamole
Otsenka éffektivnosti dipiridamola kak sredstva profilaktiki ostrykh respiratornykh virusnykh zabolevaniĭ.