The effect of ranitidine on oesophageal motility.
Ranitidine is used to treat symptomatic oesophageal reflux; its effect is probably to a great extent due to reduced gastric secretion. Whether it also affects oesophageal motility is a matter of controversy. In a randomized double-blind study oesophageal motility was recorded in 21 healthy individuals after 3 doses of 150 mg ranitidine or placebo given over 36 h. Ranitidine increased the pressure in the lower oesophageal sphincter from 14 to 18 mmHg (p = 0.05) but otherwise did not influence oesophageal motility.
Naess
F
F
Surgical Dept., Ullevål Hospital, University of Oslo, Norway.
Nygaard
K
K
Haffner
J
J
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004947:Esophagus / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D010528:Peristalsis / Q000187:drug effects; D011897:Random Allocation; D011899:Ranitidine / Q000008:administration & dosage* / Q000494:pharmacology
D011899:Ranitidine