Platelet-directed antibody in the serum of patients with primary thrombotic thrombocytopenic purpura.
Utilizing two platelet antibody assay systems, flow cytometric analysis and a microcytotoxicity assay, it was possible to demonstrate for the first time platelet-directed antibody in the sera of three of six patients with primary thrombotic thrombocytopenic purpura. These results lend support for an immune-mediated pathologic process in some patients with this disorder.
Lazarchick
J
J
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston 29425.
Graddick
S L
SL
Hall
S A
SA
Genco
P V
PV
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001792:Blood Platelets / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008875:Middle Aged; D011697:Purpura, Thrombotic Thrombocytopenic / Q000276:immunology*
D001323:Autoantibodies