Saturable transport of peptides across the blood-brain barrier.
Peptides can be transported across the blood-brain barrier by saturable transport systems. One system, characterized with radioactively labeled Tyr-MIF-1 (Tyr-Pro-Leu-Gly-amide), is specific for some of the small peptides with an N-terminal tyrosine, including Tyr-MIF-1, the enkephalins, beta-casomorphin, and dynorphin (1-8). Another separate system transports vasopressin-like peptides. The choroid plexus has at least one system distinguishable from those above that is capable of uptake and possibly transport of opiate-like peptides. The possibility of saturable transport of other peptides has been investigated to a varying degree. Specificity, stereo-specificity, saturability, allosteric regulation, modulation by physiologic and pharmacologic manipulations, and noncompetitive inhibition have been demonstrated to occur in peptide transport systems and suggest a role for them in physiology and disease.
Banks
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Kastin
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D000375:Aging; D000535:Aluminum / Q000633:toxicity; D000818:Animals; D001692:Biological Transport; D001812:Blood-Brain Barrier; D002940:Circadian Rhythm; D006801:Humans; D010455:Peptides / Q000378:metabolism*; D013312:Stress, Physiological / Q000503:physiopathology
D010455:Peptides; D000535:Aluminum