Relationships between ionizing radiation, bone marrow transplantation and leukemogenesis.
Studies of the relationships between ionizing radiation, bone marrow transplantation and leukemogenesis were carried out in 343 LACA mice. The recipients (female) were given whole-body irradiation with 7 or 8 Gy of Co-60 gamma-rays, while the donors (male) were given whole-body irradiation with 3, 1.5, 0.5, 0.1, 0.05 and 0 Gy of Co-60 gamma-rays. Each recipient was intravenously infused with 1-3 X 10(7) of the mixed marrow cells of donors. In the result, the average incidence of surviving over 1 month was 86% in the recipients. Myelocytic leukemia developed in all the transplanted groups, the average incidence being 88.5%. Leukemia was observed in 1.5-2.5 months after transplantation in the recipients receiving marrow cells from donors exposed to 3 Gy, but in 5-8 months in other groups. It was demonstrated by the analysis of Y-chromosome that the leukemic cells were derived from the donor's marrow cells. The results suggest that marrow transplantation for the mice irradiated by Co-60 gamma-rays of lethal dose can protect them from death, but promote the development of leukemia. Radiation can induce production of factors which lead to leukemic transformation of engrafted normal marrow cells in the irradiated mice; the direct damage of DNA caused by radiation is not the unique factor that gives rise to leukemia.
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D000818:Animals; D016026:Bone Marrow Transplantation; D005260:Female; D007942:Leukemia, Experimental / Q000209:etiology*; D007953:Leukemia, Radiation-Induced / Q000209:etiology*; D008297:Male; D051379:Mice; D014916:Whole-Body Irradiation / Q000009:adverse effects*