title: Insulin receptor evaluation in congenital generalized lipodystrophy. Case report of an infant.
abstract: Insulin specific receptors on red blood cells and cultured fibroblasts were investigated in a male infant affected of congenital generalized lipodystrophy (CGL). Total insulin binding capacity appeared mildly reduced, with apparently selective involvement of the high-affinity receptors on red blood cells but not on fibroblasts. Such alterations did not produce any impairment of glucose metabolism.
authors.affiliation: Department of Pediatrics, University of Pavia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Aricò
authors.forename: A
authors.initials: A
authors.lastname: Ricordi
authors.forename: D
authors.initials: D
authors.lastname: Caselli
authors.forename: M
authors.initials: M
authors.lastname: Aschei
authors.forename: A
authors.initials: A
authors.lastname: Colombo
authors.forename: P
authors.initials: P
authors.lastname: Fratino
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D002478:Cells, Cultured; D004912:Erythrocytes / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D007223:Infant; D007328:Insulin / Q000097:blood; D008060:Lipodystrophy / Q000151:congenital* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D011972:Receptor, Insulin / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D011972:Receptor, Insulin