Fructose-induced insulin resistance and hypertension in rats.
To determine if hypertension could be produced in normal rats by feeding them a fructose-enriched diet, Sprague-Dawley rats were fed either normal chow or a diet containing 66% fructose as a percentage of total calories for approximately 2 weeks. At the end of this period systolic blood pressure had increased from 124 +/- 2 to 145 +/- 2 (SEM) mm Hg in the fructose-fed rats, whereas no change occurred in the control group. In addition, hyperinsulinemia and hypertriglyceridemia were associated with hypertension in fructose-fed rats. The addition of clonidine to the drinking water inhibited fructose-induced hypertension, but not the increase in plasma insulin or triglyceride concentration seen in fructose-fed rats. Thus, the metabolic changes associated with fructose-induced hypertension are unlikely to be secondary to an increase in sympathetic activity. Whether or not this is also true of the hypertension remains to be clarified.
Hwang
I S
IS
Department of Medicine, Stanford University School of Medicine, Palo Alto, California.
Ho
H
H
Hoffman
B B
BB
Reaven
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GM
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003000:Clonidine / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005632:Fructose; D006973:Hypertension / Q000139:chemically induced* / Q000517:prevention & control; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014280:Triglycerides; D005632:Fructose; D003000:Clonidine