title: Cap Z(36/32), a barbed end actin-capping protein, is a component of the Z-line of skeletal muscle.
abstract: Various biological activities have been attributed to actin-capping proteins based on their in vitro effects on actin filaments. However, there is little direct evidence for their in vivo activities. In this paper, we show that Cap Z(36/32), a barbed end, actin-capping protein isolated from muscle (Casella, J. F., D. J. Maack, and S. Lin, 1986, J. Biol. Chem., 261:10915-10921) is localized to the barbed ends of actin filaments by electron microscopy and to the Z-line of chicken skeletal muscle by indirect immunofluorescence and electron microscopy. Since actin filaments associate with the Z-line at their barbed ends, these findings suggest that Cap Z(36/32) may play a role in regulating length, orienting, or attaching actin filaments to Z-discs.
authors.forename: J F
authors.initials: JF
authors.lastname: Casella
authors.forename: S W
authors.initials: SW
authors.lastname: Craig
authors.forename: D J
authors.initials: DJ
authors.lastname: Maack
authors.forename: A E
authors.initials: AE
authors.lastname: Brown
mesh_terms: D051344:Actin Capping Proteins; D008841:Actin Cytoskeleton / Q000032:analysis* / Q000648:ultrastructure; D051339:Actin Depolymerizing Factors; D000199:Actins / Q000032:analysis*; D000818:Animals; D000906:Antibodies / Q000276:immunology; D002645:Chickens; D003599:Cytoskeleton / Q000032:analysis*; D051345:Destrin; D005455:Fluorescent Antibody Technique; D008840:Microfilament Proteins; D008854:Microscopy, Electron; D009132:Muscles / Q000648:ultrastructure*; D011506:Proteins / Q000032:analysis* / Q000276:immunology / Q000502:physiology
chemical_list: D051344:Actin Capping Proteins; D051339:Actin Depolymerizing Factors; D000199:Actins; D000906:Antibodies; D051345:Destrin; D008840:Microfilament Proteins; D011506:Proteins