Effectiveness of pinaverium bromide in the treatment of primitive biliary dyskinesia: 99mTc-P-IDA scintigraphic evaluation.
The 99mTc-P-IDA (technetium-p-iminodiacetic acid) hepatocholangiocholecystoscintigraphy is a diagnostic technique which allows information on the liver biligenetic and excretory capabilities to be obtained. It is, moreover, a test that mirrors closely the anatomic and functional conditions of the cholecyst and choledochus. In this study the authors wanted to verify whether pinaverium bromide, a drug with a documented musculotropic-spasmolytic activity, was able to induce changes in some abnormal instrumental parameters observed in 24 subjects with primitive biliary dyskinesia. The results revealed that the ti values, characteristically longer in those subjects, were significantly reduced in the group of patients treated with pinaverium bromide. On the contrary, in the group of patients treated with placebo, there was no change with respect to this parameter.
Scaffidi
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Institute of Clinical Medicine, University of Palermo, Italy.
Costa
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Frontespezi
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D000328:Adult; D001657:Biliary Dyskinesia / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007098:Imino Acids; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000627:therapeutic use*; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D010276:Parasympatholytics / Q000627:therapeutic use*; D011877:Radionuclide Imaging; D011897:Random Allocation
D007098:Imino Acids; D009025:Morpholines; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D010276:Parasympatholytics; C046767:technetium Tc 99m iminodiacetic acid; C013199:pinaverium