The processing and secretion of rat serum albumin by oocytes from Xenopus laevis.
Microinjection of rat liver mRNA into Xenopus oocytes led to the synthesis of intracellular proalbumin and the secretion of mature albumin into the incubation medium. The ionophore monensin abolished the secretion of albumin but not the processing of the precursor. A variety of protease inhibitors were added to the incubation medium but there was no detectable inhibition of proalbumin cleavage.
Foreman
R C
RC
Judah
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JD
D000818:Animals; D005260:Female; D006868:Hydrolysis; D008985:Monensin / Q000494:pharmacology; D009865:Oocytes / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism; D011228:Prealbumin / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014982:Xenopus laevis
D011228:Prealbumin; D008985:Monensin; D010447:Peptide Hydrolases