Cell proliferation in rat kidney induced by 1,2-dibromoethane.
The effect of a single intragastric injection of 1,2-dibromoethane was investigated in kidneys of male Wistar rats. DNA synthesis as measured by the incorporation of tritiated thymidine was found to be approximately 5 times greater than that of controls 20-30 h after treatment. DNA synthesis was followed by a striking increase in the mitotic activity with a maximum at 30 h. The labeling and mitotic activities, after an initial increase, fell rapidly 48 h after treatment even though they were still higher than those of control animals. 1,2-Dibromoethane-induced cell proliferation is not a regenerative response because at the dose used in this study, no tubular necrosis was observed by histologic examination.
Ledda-Columbano
G M
GM
Columbano
A
A
Coni
P
P
Curto
M
M
Faa
G
G
Pani
P
P
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D015946:Ethylene Dibromide / Q000633:toxicity*; D006842:Hydrocarbons, Brominated / Q000633:toxicity*; D007668:Kidney / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008938:Mitosis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine / Q000378:metabolism
D006842:Hydrocarbons, Brominated; D015946:Ethylene Dibromide; D004247:DNA; D013936:Thymidine