[Delayed-type hypersensitivity to minor histocompatibility antigens and its genetic restriction].
The analysis of skin allograft survival time and the level of delayed-type hypersensitivity (DTH) reaction to major and minor histocompatibility antigens revealed the correlation between these parameters of the transplantation immunity. The data obtained have shown that histocompatibility in several non-H-2 antigens induces DTH reaction comparable with the reaction caused by H-2 antigens. The effector phase of DTH to non-H-2 antigens is H-2 restricted. No restriction of the afferent phase is revealed. The application of these results to the analysis of the mechanisms of the recognition of minor histocompatibility antigens in DTH is discussed.
Liadova
I V
IV
Fontalin
L N
LN
D000818:Animals; D005260:Female; D006183:H-2 Antigens / Q000235:genetics; D006649:Histocompatibility Antigens / Q000235:genetics / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016038:Skin Transplantation; D014181:Transplantation Immunology
D006183:H-2 Antigens; D006649:Histocompatibility Antigens
Giperchuvstvitel'nost' zamedlennogo tipa k slabym antigenam gistosovmestimosti i ee geneticheskaia restriktsiia.