The effect of microwave radiation on the primary IgM response to sheep red blood cells in mice.
We investigated the changes in the number of plaque-forming cells (PFC) in spleens of CBA mice after microwave (MW) irradiation. The mice were immunized with sheep red blood cells, the number of PFC was determined on days 4 and 5 after immunization. Mice received single doses of MW irradiation on days 1, 2, or 3 after immunization (exposure duration 1 to 9 min). It was found that the number of PFC was changed after MW irradiation and that this effect depended on the absorbed dose. Shorter exposures for 1, 3, and 5 min (SA = 4, 12, and 20.1 kJ/kg) stimulated the formation of PFC, exposures for 7 and 9 min did not change the number of PFC. After MW heating (exposure 5 min), the rectal temperature of mice was elevated by 2.5 degrees C. If the same thermal effect was induced by elevating the environmental temperature, the number of PFC was not increased. The observed changes in PFC number are probably due to the specific effect of MW radiation.
Lojek
A
A
Cesnek
J
J
Misustová
J
J
D000818:Animals; D004912:Erythrocytes / Q000276:immunology / Q000528:radiation effects*; D005260:Female; D006462:Hemolytic Plaque Technique; D007075:Immunoglobulin M / Q000096:biosynthesis*; D051379:Mice; D008808:Mice, Inbred CBA; D008872:Microwaves; D012756:Sheep / Q000276:immunology
D007075:Immunoglobulin M