[Oncogene products as tumor markers].
Monoclonal antibodies reactive with ras gene products were produced. Specificity of the antibodies obtained was determined by ELISA and immunoblotting assays. Using one of those anti-ras p21 monoclonal antibodies, RASK-3 the expression of p21 in human stomach cancer and thyroid cancer was studied by means of immuno-histochemistry. ras p21 was more dominantly expressed in cancer cells than in normal epithelial cells.
Shiku
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D000911:Antibodies, Monoclonal; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis*; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000276:immunology; D016283:Proto-Oncogene Proteins p21(ras); D013274:Stomach Neoplasms / Q000175:diagnosis; D013964:Thyroid Neoplasms / Q000175:diagnosis
D000911:Antibodies, Monoclonal; D011518:Proto-Oncogene Proteins; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)