title: A case of cebocephaly-holoprosencephaly with an aberrant adenohypophysis.
abstract: An autopsy case of cebocephaly-holoprosencephaly at 27 weeks' gestation is reported. Chromosome analysis revealed a 46, XX,-7, +der(7), t(7;13) (q32;q34) pat karyotype. Pathological examination disclosed a hypoplastic aberrant adenohypophysis, in which immunohistochemical localization of four anterior pituitary hormones (ACTH, GH, PRL, TSH-beta) was demonstrated. Malformation of the pituitary gland in holoprosencephaly can include ectopic adenohypophysis as well as pituitary dysgenesis, so a careful search for adenohypophysis should be made in future cases for a better understanding of endocrine dysgenesis associated with holoprosencephaly.
authors.affiliation: Division of Neurosurgery, Tohoku University, Sendai, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Niizuma
authors.forename: J
authors.initials: J
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Takabayashi
authors.forename: N
authors.initials: N
authors.lastname: Ozawa
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics / Q000473:pathology*; D001921:Brain / Q000002:abnormalities* / Q000473:pathology; D002828:Choristoma / Q000473:pathology*; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D010255:Paranasal Sinus Neoplasms / Q000473:pathology*; D010903:Pituitary Gland, Anterior; D010908:Pituitary Hormones, Anterior / Q000378:metabolism; D013101:Sphenoid Sinus / Q000473:pathology*
chemical_list: D010908:Pituitary Hormones, Anterior