title: Islet cell surface antibodies (ICSA) in subjects with a previous mumps infection--a prospective study over a 4 year period.
abstract: It has been suggested that the mumps virus may be involved in the etiopathogenesis of Type-I diabetes mellitus. Most studies have analyzed this relationship retrospectively. We, however, carried out a prospective study over a 4 year period after a mumps infection in two age groups (16 years and under [group A no = 32] and over 16 years [group B no = 18]). These subjects with "diabetic risk factors" (impaired glucose tolerance, low insulin response, ICSA and/or HLA-DR3/DR4) were selected from 1581 registered cases, in whom an antecedent mumps infection had occurred in 1980 and 1981. Glucose tolerance and insulin secretion did not change significantly during 4 years after a mumps infection. Overt diabetes was not observed in any of the cases. One year after a mumps infection 35% of children and 63% of adolescents/adults exhibited ICSA (control subjects = 5%; a serum was considered ICSA-positive if more than 25% of the intact rat islet cells showed distinct cell surface immunofluorescence). After 4 years the percentage of subjects with ICSA decreased significantly to 13% and 14%, resp. Only 21% of ICSA-positive sera were found to be cytotoxic on rat islet cells (51Cr-release assay). No relationship could be evaluated between complications resulting from a mumps infection and the appearance of ICSA. There was no correlation between ICSA, glucose tolerance, and insulin secretion. In fact, our prospective study did not reveal any relationship between a mumps infection and Type-I diabetes. ICSA would seem to be of no predictive value.
authors.affiliation: Central Institute of Diabetes, Gerhardt Katsch, Karlsburg, GDR.
authors.forename: B
authors.initials: B
authors.lastname: Schulz
authors.forename: D
authors.initials: D
authors.lastname: Michaelis
authors.forename: W
authors.initials: W
authors.lastname: Hildmann
authors.forename: S
authors.initials: S
authors.lastname: Witt
authors.forename: B
authors.initials: B
authors.lastname: Hehmke
authors.forename: I
authors.initials: I
authors.lastname: Rjasanowski
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000382:microbiology*; D005260:Female; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D008297:Male; D009107:Mumps / Q000150:complications*; D009109:Mumps virus / Q000276:immunology*; D011446:Prospective Studies
chemical_list: D000914:Antibodies, Viral