Impaired insulin-mediated erythrocyte magnesium accumulation in essential hypertension.
1. This study was designed to investigate variations in erythrocyte magnesium in the presence of insulin (0.1 unit/l) in hypertensive subjects. 2. Plasma and erythrocyte magnesium levels were found to be significantly lower in hypertensive than in normotensive subjects. 3. The impaired response to insulin (0.1 units/l) of erythrocytes from hypertensive patients was not reversed by elevated extracellular Mg2+ (3.6 mmol/l). 4. Erythrocytes of hypertensive subjects showed an increased membrane microviscosity compared with normotensive subjects. 5. Lidocaine decreased erythrocyte membrane microviscosity and increased erythrocyte magnesium levels in the presence of insulin.
Paolisso
G
G
Istituto di Medicina Generale, Terapia e Malattie del Metabolismo, 1st Medical School, University of Naples, Italy.
Passariello
N
N
Sgambato
S
S
Torecca
R
R
Buoninconti
R
R
Varricchio
M
M
D'Onofrio
F
F
D000328:Adult; D001809:Blood Viscosity; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007328:Insulin / Q000494:pharmacology / Q000502:physiology*; D008012:Lidocaine / Q000494:pharmacology; D008274:Magnesium / Q000097:blood* / Q000494:pharmacology; D008297:Male
D007328:Insulin; D008012:Lidocaine; D008274:Magnesium