99mTc-2,3-diaminopropionic acid complex as renal function agent: comparison of biological properties with 99mTc-DTPA and 131I-OIH.
The preparation, purification, biodistribution, blood disappearance kinetics and imaging characteristics of 99mTc-2,3-diamino propionic acid (99m-Tc-DAPA) is studied. The latter three studies were conducted on rabbits as the experimental animal and the data thus obtained were compared with 99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA) and 131I-orthoiodohippurate (131I-OIH) with a view to find a possible replacement of the latter radiopharmaceutical with a more convenient 99mTc based compound. Preliminary data indicates favourable results for 99mTc-2,3-diamino propionic acid which warrants further investigation.
Chattopadhyay
M
M
Indian Institute of Chemical Biology, Calcutta.
Jalan
K N
KN
Pal
A K
AK
Banerjee
S N
SN
D000818:Animals; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid / Q000493:pharmacokinetics; D007668:Kidney / Q000000981:diagnostic imaging*; D007700:Kinetics; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D004369:Pentetic Acid / Q000493:pharmacokinetics; D011817:Rabbits; D011877:Radionuclide Imaging; D016284:Technetium Tc 99m Pentetate; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D009942:Organometallic Compounds; D007465:Iodohippuric Acid; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate