S-100 protein in Schwann cells of the developing human peripheral nerve. An immunohistochemical study.
From approximately 7 weeks gestational age in developing human peripheral nerve, as in adult nerve, S-100 protein was found to be expressed solely and uniformly by Schwann cells associated with axons. In embryos younger than 7 weeks S-100 was much less constant and many cells did not show clear staining. The trigger for the initial appearance of the protein at around this age remains unclear although a relationship of S-100 expression in Schwann cells to close axonal contact is suggested. The value of S-100 protein in distinguishing Schwann cells from perineurial cells in normal nerves and nerve sheath tumours remains unclear.
Shearman
J D
JD
Franks
A J
AJ
D004622:Embryo, Mammalian; D005260:Female; D005333:Fetus; D005865:Gestational Age; D006801:Humans; D007124:Immunoenzyme Techniques; D010525:Peripheral Nerves / Q000166:cytology / Q000196:embryology*; D011247:Pregnancy; D009418:S100 Proteins / Q000032:analysis*; D012583:Schwann Cells / Q000166:cytology*
D009418:S100 Proteins