Effect of captopril on angiotensin II release from vascular tissues in rats.
Isolated rat hindlegs were perfused with Krebs-Ringer solution and released angiotensin I (ANG I) and ANG II were determined. The release of ANG I and ANG II in nephrectomized rats did not differ from those in control group. Pretreatment with captopril (50 mg/kg/day) for 3 days or addition of captopril (2 X 10(-6) M) to the perfusate induced increase in ANG I release and decrease in ANG II release. These findings suggest that ANG II is locally generated and release from the vascular tissues. Captopril may inhibit the conversion of vascular ANG I into ANG II.
Nakamaru
M
M
Inagami
T
T
Ogihara
T
T
Kumahara
Y
Y
D000803:Angiotensin I / Q000378:metabolism; D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001808:Blood Vessels / Q000378:metabolism*; D002216:Captopril / Q000494:pharmacology*; D006614:Hindlimb / Q000098:blood supply; D008297:Male; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains
D000804:Angiotensin II; D000803:Angiotensin I; D002216:Captopril