title: Double-blind study comparing aztreonam with placebo for prophylaxis of infection following prostatic surgery.
abstract: In a prospective, randomised, double-blind study, 179 patients undergoing retropubic or transurethral prostatectomy were given pre-operatively either 1 g aztreonam or a placebo. In patients treated with aztreonam there was a significant reduction in the number with post-operative bacteriuria and in the number requiring treatment of post-operative bacteriuria. Other differences were not significant. The mean duration of post-operative hospital stay for patients receiving aztreonam was 7.1 days compared with 6.9 days for those receiving placebo. In patients treated with aztreonam there was no increase in the frequency of infections due to Gram-positive bacterial species.
authors.affiliation: Department of Medical Microbiology, University of Leeds.
authors.forename: M R
authors.initials: MR
authors.lastname: Millar
authors.forename: T
authors.initials: T
authors.lastname: Inglis
authors.forename: R
authors.initials: R
authors.lastname: Ewing
authors.forename: P
authors.initials: P
authors.lastname: Clark
authors.forename: R E
authors.initials: RE
authors.lastname: Williams
authors.forename: R W
authors.initials: RW
authors.lastname: Lacey
mesh_terms: D001398:Aztreonam / Q000627:therapeutic use*; D001437:Bacteriuria / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication; D011446:Prospective Studies; D011468:Prostatectomy; D011897:Random Allocation
chemical_list: D001398:Aztreonam