The Ity/Lsh/Bcg gene significantly affects mouse resistance to Mycobacterium lepraemurium.
Mouse resistance to infection with Mycobacterium lepraemurium was measured by counting the total number of intact acid-fast bacilli in the spleen 8 weeks after i.v. injection of a standard inoculation. The effect of Ityr on resistance to M. lepraemurium was confirmed and the results extended to two Ityr strains of mice, A and C57L, not previously tested. Resistance to M. lepraemurium was also examined in the F1, backcross and F2 generations of BALB/c X CBA crosses, and in the congenic strain B10.LLshr that is Ityr. In all experiments the results were consistent with the view that resistance to M. lepraemurium is significantly affected by a gene close to or identical to the Ity/Lsh/Bcg gene on mouse chromosome 1. Sex had a marked effect on resistance to M. lepraemurium, so that the males of some genetically resistant strains were almost as susceptible as some genetically susceptible females.
Brown
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St Mary's Hospital Medical School, London, U.K.
Glynn
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D000818:Animals; D003433:Crosses, Genetic; D004198:Disease Susceptibility; D005260:Female; D005796:Genes; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009164:Mycobacterium Infections / Q000235:genetics* / Q000382:microbiology; D009167:Mycobacterium lepraemurium / Q000302:isolation & purification; D012737:Sex Factors; D013154:Spleen / Q000382:microbiology