[Influence of the anti-HLA immunization profile before grafting on the outcome of renal transplant].
A retrospective study of HLA immunization profile before a first graft of unrelated kidney in 212 immunized recipients (with an initial peak greater than or equal to 25%) shows that one can define at least 3 groups of responder with a different graft outcome. Recipients with either weak or strong variance of HLA antibody (VP) before graft (group I: VP less than 230 and group III: VP greater than 830) have a significantly lower graft survival: 54% (p = 0.006) and 45% (p = 0.002) respectively at 4 years, than recipients of group II (230 less than VP less than 830) for whom the prognosis is of 77% after the same time period. If similar results are observed on independent series, VP would be of a great interest for the definition of a new classification of responders, and on a practical level for the choice of renal transplant.
Busson
M
M
Bouteiller
A M
AM
Prévost
P
P
Raffoux
C
C
Hors
J
J
D000906:Antibodies / Q000032:analysis*; D006085:Graft Survival; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007114:Immunization; D016030:Kidney Transplantation; D011379:Prognosis; D012189:Retrospective Studies
D000906:Antibodies; D006680:HLA Antigens
Influence du profil d'immunisation anti-HLA avant greffe sur le devenir du greffon renal.