Elevation of urinary trehalase activity in patients of itai-itai disease.
The elevation of urinary trehalase activity in patients of itai-itai disease was examined. Urinary trehalase was correlated with tubular reabsorption of phosphorus (%TRP): the lower the trehalase activity, the worse was %TRP. Furthermore, this activity was inversely correlated with urinary glucose and urinary total protein. In itai-itai disease, the excretion of beta 2-microglobulin seems to be maximal, and urinary trehalase activity was low in the latter stages of the disease. It is inferred that itai-itai disease produces extremely severe tubular damage as well as glomerular dysfunction.
Nakano
M
M
Aoshima
K
K
Katoh
T
T
Teranishi
H
H
Kasuya
M
M
D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000652:urine; D002104:Cadmium / Q000652:urine; D002105:Cadmium Poisoning / Q000201:enzymology* / Q000652:urine; D005260:Female; D006029:Glycosuria / Q000652:urine; D006801:Humans; D007931:Leucyl Aminopeptidase / Q000652:urine; D008875:Middle Aged; D011507:Proteinuria / Q000139:chemically induced; D014198:Trehalase / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine
D001613:beta 2-Microglobulin; D002104:Cadmium; D000469:Alkaline Phosphatase; D014198:Trehalase; D007931:Leucyl Aminopeptidase