[Determination of blood ceftriaxone. Comparison of microbiological and HPLC methods].
108 serum samples in 27 patients were collected after the first, before the second, after and before the fifth dose of 2 g every 24 h and assayed for ceftriaxone by microbiological method and high pressure liquid chromatography (HPLC). The statistical analysis of the results show a correlation coefficient equal to 0.95. The protein binding doesn't affect the microbiological method. The two methods are convenient for clinical use.
de Barbeyrac
B
B
Laboratoire de Bactériologie, Hôpital Pellegrin, Bordeaux.
Penouil
F
F
Gardère
J J
JJ
Saux
M C
MC
Brachet-Liermain
A
A
Bebear
C
C
D001431:Bacteriological Techniques; D002443:Ceftriaxone / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D006801:Humans
D002443:Ceftriaxone
Dosage sérique de la ceftriaxone. Comparaison des méthodes par microbiologie et CLHP.