title: Long-term follow-up of 500 patients with mild to moderate hypertension who had successfully completed a 3-month general practice study of a timolol-bendrofluazide combination ('Prestim').
abstract: A sample of 500 patients with mild to moderate hypertension, who had been successfully controlled on once daily timolol/bendrofluazide at the end of a 3-month general practice study, was followed up after approximately 1 year of treatment. Physicians who had participated in the trial were questioned on the current status of these patients. Out of 479 reports received, data showed that 358 (75%) patients were still normotensive 47 weeks after starting treatment with timolol/bendrofluazide and in a further 8 patients other antihypertensive agents had been added to this therapy. Of the 113 patients no longer receiving timolol/bendrofluazide, only 38 (7.9%) had stopped therapy due to adverse effects. It is concluded that the results are a further indication that timolol/bendrofluazide offers an acceptable and balanced long-term form of therapy in hypertension for both the patient and the physician.
authors.affiliation: Medical Department, Leo Laboratories Ltd., Princes Risborough, England.
authors.forename: A C
authors.initials: AC
authors.lastname: Head
authors.forename: B T
authors.initials: BT
authors.lastname: Marsh
authors.forename: I T
authors.initials: IT
authors.lastname: Fairey
mesh_terms: D000328:Adult; D000368:Aged; D001539:Bendroflumethiazide / Q000009:adverse effects / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D002986:Clinical Trials as Topic; D004338:Drug Combinations / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011674:Pulse / Q000187:drug effects; D013999:Timolol / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D001539:Bendroflumethiazide; C038311:prestim; D013999:Timolol