[Diffusion of vancomycin in the cerebrospinal fluid, in the dog, in the absence of meningeal inflammation].
The diffusion of vancomycin into the cerebro-spinal fluid was studied in 5 healthy dogs. Its appears that vancomycin does diffuse across the blood-brain barrier. Though the concentrations reached in the CSF are low, they are of the same order of magnitude as the minimal inhibitory concentrations of this antibiotic towards the germs usually treated. The usual pharmacokinetic parameters were determined.
Chabenat
C
C
Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, Saint-Etienne-du-Rouvray, France.
Moore
N
N
Flipo
J L
JL
Barois
A
A
Boismare
F
F
Boucly
P
P
D000818:Animals; D001812:Blood-Brain Barrier; D004058:Diffusion; D004285:Dogs; D008297:Male; D008578:Meninges / Q000378:metabolism; D012016:Reference Values; D014640:Vancomycin / Q000097:blood / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics
D014640:Vancomycin
Diffusion de la vancomycine dans le liquide céphalo-rachidien, chez le chien, en l'absence d'inflammation méningée.