[Chromosome aberrations and malignant lymphomas].
Chromosomal findings in malignant lymphomas are correlated to the histopathology and the immunologic phenotype of lymphoma subgroups. The prognostic significance of a cytogenetic analysis and its value for therapy planning are discussed. With respect to tumorigenesis it is emphasized that a number of proto-oncogenes and genes for cell differentiation, such as immunoglobulin and T-cell receptor genes, have been localized at sites of recurring chromosomal rearrangements. One chapter deals with cytogenetic data in correlation to findings of DNA recombination studies in Hodgkin's disease.
Fonatsch
C
C
Institut für Humangenetik, Medizinische Universität zu Lübeck.
Gradl
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G
D002869:Chromosome Aberrations; D006689:Hodgkin Disease / Q000235:genetics*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D011379:Prognosis; D011519:Proto-Oncogenes
Chromosomenaberrationen und maligne Lymphome.