title: [Cardiotoxicity of 5-fluorouracil. Personal cases and review of the literature].
abstract: Two cases of 5-Fluorouracil (5FU) cardiotoxicity, chest pain with changes in ECG the former, and myocardial infarction the latter, are described. Review of literature shows the existence of 49 cases of cardiotoxicity due to 5FU (38 angina = 77.5% 8 myocardial infarction = 16.3%). This complication seems due to a "coronary toxicity" whose onset is very precocious and not dose-dependent. Since 5FU therapy could result very dangerous when cardiotoxicity occurs, it is strictly advisable to withdraw further administration of the drug. As a matter of fact 18 patients out of 21 who again were treated with 5FU, had more serious complications which resulted in 3 myocardial infarctions (2 deaths).
authors.affiliation: Divisione di Medicina Generale, Ospedale Bassini, Milano.
authors.forename: G
authors.initials: G
authors.lastname: Segalini
authors.forename: R
authors.initials: R
authors.lastname: Labianca
authors.forename: G D
authors.initials: GD
authors.lastname: Beretta
authors.forename: E
authors.initials: E
authors.lastname: Borsotti
authors.forename: F
authors.initials: F
authors.lastname: Calasso
authors.forename: L
authors.initials: L
authors.lastname: Carini
authors.forename: S
authors.initials: S
authors.lastname: De Ceglia
authors.forename: A
authors.initials: A
authors.lastname: Rocca
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000139:chemically induced*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced*
chemical_list: D005472:Fluorouracil
vernacular_title: Cardiotossicità da 5-fluorouracile. Casistica personale e revisione della letteratura.