[Influence of captopril on the in vitro and in vivo effects of leu- and met-enkephalins].
Captopril (10(-6) g/ml) enhanced and prolonged the inhibitory effect of leu- and met-enkephalins on the contractions of the isolated guinea-pig ileum section induced by electrical stimulation. In mice, the drug (25 mg/kg, subcutaneously) increased the degree and duration of the analgetic effect of enkephalins. It is concluded that the analgetic effect of captopril is related to the influence on the activity of the endogenous antinociceptive system.
Shvarts
G Ia
GIa
Faermark
I F
IF
D000818:Animals; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004743:Enkephalin, Leucine / Q000494:pharmacology* / Q000627:therapeutic use; D004744:Enkephalin, Methionine / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy; D013997:Time Factors
D009270:Naloxone; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D002216:Captopril
Vliianie kaptoprila na éffekty leĭ- i met-énkefalinov in vitro i in vivo.