title: Active immunization against hepatitis B: immunogenicity of a recombinant DNA vaccine in females, heterosexual and homosexual males.
abstract: Three groups of subjects (58 females, 54 heterosexual males, and 50 homosexual males) received three doses of a recombinant DNA yeast-derived hepatitis B vaccine according to a 0, 1, and 6 month vaccination schedule. Local and general side effects were mild. Seroconversion rates after three injections were not significantly different between the groups. Females showed a significantly higher anti-HBs response than both groups of males, and heterosexual males had higher antibody titres than homosexual males. Among the four homosexual non-responders, three were carriers of the human immunodeficiency virus.
authors.affiliation: Landesinstitut für Tropenmedizin, Berlin, FRG.
authors.forename: U
authors.initials: U
authors.lastname: Laukamm-Josten
authors.forename: G
authors.initials: G
authors.lastname: von Laer
authors.forename: H
authors.initials: H
authors.lastname: Feldmeier
authors.forename: U
authors.initials: U
authors.lastname: Bienzle
authors.forename: A
authors.initials: A
authors.lastname: Uy
authors.forename: R
authors.initials: R
authors.lastname: Thomssen
authors.forename: I
authors.initials: I
authors.lastname: Guggenmoos-Holzmann
mesh_terms: D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000627:therapeutic use*; D004274:DNA, Recombinant / Q000276:immunology; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006716:Homosexuality; D006801:Humans; D008297:Male; D008875:Middle Aged; D012441:Saccharomyces cerevisiae / Q000235:genetics; D013997:Time Factors; D014611:Vaccination / Q000009:adverse effects; D014614:Vaccines, Synthetic / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000941:Antigens; D004274:DNA, Recombinant; D006510:Hepatitis B Antibodies; D014614:Vaccines, Synthetic