title: Estrogen and progesterone receptor determination in the papillary cystic neoplasm of the pancreas. With immunohistochemical and ultrastructural observations.
abstract: Two cases of papillary cystic neoplasm (PCN) of the pancreas occurring in 18- and 34-year-old women are described. In both, the clinicopathologic features were typical. Immunohistochemical staining for neuron-specific enolase (NSE), S100 protein (S100), alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), and several peptide hormones was negative. Alpha-1-antitrypsin immunoreactivity was prominent, and its significance is discussed. Ultrastructural features were most compatible with partial acinar differentiation. Of the well-described cases of PCN, approximately 95% have occurred in women between the ages of 12 and 35, suggesting a role for hormonal factors in the pathogenesis of this tumor. Consequently, tumor tissue from one patient was assayed for estrogen and progesterone receptors: significant levels of high-affinity receptors were demonstrated for both hormones. Assays for the same receptors in five normal pancreases were negative. This constitutes the first reported measurement of these receptors in the PCN; the results indicate that the PCN may be another hormone-sensitive tumor.
authors.forename: M
authors.initials: M
authors.lastname: Ladanyi
authors.forename: S
authors.initials: S
authors.lastname: Mulay
authors.forename: J
authors.initials: J
authors.lastname: Arseneau
authors.forename: P
authors.initials: P
authors.lastname: Bettez
mesh_terms: D000293:Adolescent; D000328:Adult; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D010190:Pancreatic Neoplasms / Q000032:analysis* / Q000601:surgery; D010212:Papilloma / Q000032:analysis* / Q000601:surgery; D011397:Promegestone / Q000378:metabolism; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D000515:alpha 1-Antitrypsin; D004958:Estradiol; D011397:Promegestone