title: Thoracic and abdominal lymph drainage in relation to mechanical ventilation and PEEP.
abstract: Thoracic and abdominal lymph flow have been studied in 25 dogs. Thoracic lymph flow (TLF) was found to be (mean +/- s.e. mean) 6.1 +/- 1.4 ml/h before, and 29 +/- 4.6 ml/h after the induction of lung damage with oleic acid. TLF was depressed by 50% both before and after lung damage, when a positive end-expiratory pressure (PEEP) of 1.0 kPa (10 cmH2O) was applied. This suggests impeded drainage of the lung tissue. Spontaneous breathing, compared to mechanical ventilation, significantly increased TLF by approximately 70%. Abdominal lymph flow increased from 61 +/- 5.3 ml/h to 111 +/- 12.6 ml/h, when a PEEP of 1.0 kPa was applied. These findings demonstrate that PEEP may contribute to oedema in a surgical area. It is concluded that increased intrathoracic pressure reduces TLF, and spontaneous breathing increases TLF, as compared to mechanical ventilation without PEEP.
authors.forename: C
authors.initials: C
authors.lastname: Frostell
authors.forename: H
authors.initials: H
authors.lastname: Blomqvist
authors.forename: G
authors.initials: G
authors.lastname: Hedenstierna
authors.forename: I
authors.initials: I
authors.lastname: Halbig
authors.forename: R
authors.initials: R
authors.lastname: Pieper
mesh_terms: D000005:Abdomen / Q000378:metabolism*; D000818:Animals; D004285:Dogs; D005260:Female; D008171:Lung Diseases / Q000139:chemically induced / Q000378:metabolism; D008196:Lymph / Q000378:metabolism*; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids; D011175:Positive-Pressure Respiration; D012121:Respiration, Artificial; D013909:Thorax / Q000378:metabolism*
chemical_list: D009829:Oleic Acids; D019301:Oleic Acid