Modulation of membrane protein function by bilayer lipids.
In many instances, the composition of fatty acyl groups of membrane phospholipids can be modified to achieve a range of fatty acyl unsaturation without any detectable change in bulk membrane fluidity. At the same time, the function of membrane proteins may be considerably altered, raising questions concerning the property of the lipids that brings about this altered protein function. There is some evidence that the lipids may be laterally distributed in a heterogeneous manner throughout the membrane, and changes in this distribution could be responsible for the effects on proteins. There is also increasing evidence for specific interactions between individual molecular species and membrane proteins that may also modulate membrane protein function.
Smith
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Department of Chemical Pathology, Middlesex Hospital Medical School, London, U. K.
Stubbs
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D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D008051:Lipid Bilayers / Q000378:metabolism*; D008560:Membrane Fluidity; D008565:Membrane Proteins / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism
D005227:Fatty Acids; D008051:Lipid Bilayers; D008565:Membrane Proteins; D010743:Phospholipids