title: Semisynthetic human insulin: biological and pharmacokinetic effects in normal subjects.
abstract: The assessment of pharmacokinetic and pharmacodynamic properties of semisynthetic human insulin produced by enzymatic conversion was done in normal subjects, and compared to those of highly purified pork insulin. Ten healthy volunteers were submitted to an intravenous injection of 0.06 U/kg of regular insulin, semisynthetic (Actrapid HM) and monocomponent pork insulin (Actrapid MC) in succession. No significant differences were pointed out as far as the pharmacokinetic parameters, immunoreactivity and hypoglycemic effect of both types of insulin are concerned. Only a stronger inhibition of endogenous insulin secretion, expressed by a significantly lower plasma-C-peptide levels, was observed after PPI. Stimulation of glucagon secretion was similar with both types of insulin.
authors.forename: J M
authors.initials: JM
authors.lastname: Brogard
authors.forename: D
authors.initials: D
authors.lastname: Paris-Bockel
authors.forename: J F
authors.initials: JF
authors.lastname: Blickle
authors.forename: B
authors.initials: B
authors.lastname: Cohen
authors.forename: M
authors.initials: M
authors.lastname: Pinget
authors.forename: A
authors.initials: A
authors.lastname: Stahl
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D005260:Female; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood / Q000276:immunology / Q000494:pharmacology*; D007700:Kinetics; D008297:Male
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D005934:Glucagon