Sex-steroid receptors and cancer--are we on the right tracks? (Review).
Despite the overemphasis on sex-steroid receptors in cancer, the latter remains a multifactorial process. Many hypotheses have been put forward for the interaction of steroids with receptors but relatively little attention has been paid to other binding components, e.g., antioestrogen binding sites, intracellular sex hormone binding globulin, calcium-calmodulin, protein kinases and other receptor-independent phenomena, which may be pertinent to malignancy and are reviewed in this article.
Iqbal
M J
MJ
Department of Surgery, King's College School of Medicine and Dentistry, Rayne Institute, London, England.
Colletta
A A
AA
Valyani
S H
SH
D001665:Binding Sites; D002118:Calcium / Q000502:physiology; D002147:Calmodulin / Q000502:physiology; D004965:Estrogen Antagonists / Q000378:metabolism; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D009857:Oncogenes; D011494:Protein Kinases / Q000502:physiology; D011987:Receptors, Steroid / Q000502:physiology*; D012738:Sex Hormone-Binding Globulin / Q000502:physiology
D002147:Calmodulin; D004965:Estrogen Antagonists; D006133:Growth Substances; D011987:Receptors, Steroid; D012738:Sex Hormone-Binding Globulin; D011494:Protein Kinases; D002118:Calcium