Behavioral and metabolic effects of sucrose-supplemented feeding in hyperactive rats.
Two hyperactive rat strains [spontaneously hypertensive rats (SHR) and SHR-Wistar-Kyoto cross (WK-HA)] and their nonhyperactive genetic control strain (Wistar-Kyoto) were fed ad libitum sucrose-supplemented rat chow, or chow alone in controls, to determine the effects of dietary sugar on behavior. The diets were given either overnight (acute sugar) or for 14-18 days (chronic sugar), and testing was carried out on the morning after each of the dietary schedules. The metabolic studies revealed significant strain, sex, and age differences in appetite for sucrose, caloric intake, postprandial plasma levels of glucose and insulin, and weight gain after sucrose feeding. The findings indicate that sugar feeding led to increased plasma glucose and insulin levels; however, total caloric intake was decreased, and less weight gain was observed than in chow-fed controls, particularly among the hyperactive strains. In behavioral tests, sugar feeding did not alter spontaneous activity levels in any of the strains after either acute or chronic diets. There were also no significant effects of sucrose consumption on spatial learning and memory in a plus-shaped maze as determined by use of a shock-avoidance paradigm. The only significant behavioral effects of sucrose observed were an impairment in habituation and distractibility among the WK-HA females, the most hyperactive group among these strains.
Hendley
E D
ED
Conti
L H
LH
Wessel
D J
DJ
Horton
E S
ES
Musty
R E
RE
D000367:Age Factors; D000818:Animals; D001288:Attention / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000502:physiology*; D002149:Energy Intake; D005260:Female; D006185:Habituation, Psychophysiologic; D006948:Hyperkinesis / Q000503:physiopathology*; D007328:Insulin / Q000097:blood; D007858:Learning / Q000502:physiology; D008297:Male; D008568:Memory / Q000502:physiology; D009043:Motor Activity / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013395:Sucrose / Q000502:physiology*
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin; D013395:Sucrose