Immunochemical analysis of the structure and function of chromosomal proteins.
Immunochemical approaches are useful in studying the nuclear organization and cellular function of chromosomal components. Antibodies specific to histones and to defined nonhistone proteins have been used to study nucleosome heterogeneity, to visualize the presence of histone in transcriptionally active chromatin, and to isolate DNA sequences associated with specific chromosomal proteins.
Bustin
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D000818:Animals; D000906:Antibodies; D000936:Antigen-Antibody Complex; D002868:Chromosomal Proteins, Non-Histone / Q000032:analysis; D002875:Chromosomes / Q000648:ultrastructure*; D006657:Histones / Q000032:analysis; D007118:Immunoassay; D009698:Nucleoproteins / Q000032:analysis* / Q000502:physiology
D000906:Antibodies; D000936:Antigen-Antibody Complex; D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; D009698:Nucleoproteins