title: Neonatal gallbladder enlargement and alpha 1-antitrypsin deficiency.
abstract: Patients with clinical signs of alpha 1-antitrypsin deficiency in the neonatal period usually present with prolonged obstructive jaundice. We report a patient with alpha 1-antitrypsin deficiency who presented with gallbladder enlargement in the neonatal period. This gallbladder enlargement may be due to cystic duct hypoplasia or atresia, which has been reported in association with alpha 1-antitrypsin deficiency. The diagnosis of alpha 1-antitrypsin deficiency should be considered in neonates with gallbladder enlargement and prolonged obstructive jaundice.
authors.affiliation: Department of Pediatrics, University of South Alabama Medical Center, Mobile 36617.
authors.forename: D A
authors.initials: DA
authors.lastname: Gremse
authors.forename: K J
authors.initials: KJ
authors.lastname: Peevy
authors.forename: N
authors.initials: N
authors.lastname: Simon
authors.forename: H J
authors.initials: HJ
authors.lastname: Wiseman
mesh_terms: D005705:Gallbladder Diseases / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D006984:Hypertrophy; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000150:complications; D008297:Male; D014463:Ultrasonography; D000515:alpha 1-Antitrypsin / Q000032:analysis; D019896:alpha 1-Antitrypsin Deficiency
chemical_list: D000515:alpha 1-Antitrypsin