title: Autoimmunity and chondrolysis of the hip. A report of two cases.
abstract: Two patients with rapidly progressive chondrolysis of the hip are reported. Immunofluorescent staining showed deposits of immunoglobulins and complement components in the synovium and the remaining femoral head cartilage. Seven patients with osteoarthritis of the hip and knee, or femoral neck fractures, were used as controls and all had a negative immunofluorescent staining reaction in the synovium. We suggest that an autoimmune reaction against articular cartilage antigens may play a role in the development of chondrolysis.
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshioka
authors.forename: K
authors.initials: K
authors.lastname: Shichikawa
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000473:pathology*; D002357:Cartilage Diseases / Q000276:immunology*; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D005270:Femur Head / Q000276:immunology / Q000473:pathology; D005455:Fluorescent Antibody Technique; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008875:Middle Aged; D011859:Radiography; D013583:Synovial Membrane / Q000276:immunology
chemical_list: D007136:Immunoglobulins; D003165:Complement System Proteins