Changes in vascular endothelium and its function in systemic arterial hypertension.
The various functions of arterial endothelium may be altered during pulmonary and arterial hypertension. Changes in the endothelium (or function) associated with hypertension are described. In both acute and chronic hypertension, permeability of the endothelium is enhanced. During the acute phase of hypertension, hyperplasia (cell replication) of the endothelium occurs while cell hypertrophy (enlarged cell size) and an increase in homocellular tight junctions are associated with sustained elevations of blood pressure. Endothelium may contribute to the increase in smooth muscle mass or cell number reported with various models of hypertension. Increased endothelial uptake or metabolism of norepinephrine and serotonin occurs during hypertension. The biotransformation of adenine nucleotides and various peptides by the endothelium is not altered by hypertension. Synthesis of prostacyclin is enhanced in the spontaneously hypertensive and Goldblatt hypertensive rat. Metabolism of prostaglandin E2, prostaglandin F2 alpha and prostacyclin by prostaglandin 15-hydroxydehydrogenase is impaired in the genetic models. Responses to endothelium-dependent vasodilators are impaired in acute and chronic models of hypertension. Production of relaxing factor by the endothelium is not inhibited, but rather the vascular smooth muscle fails to respond. Acute, severe hypertension potentiates the response to serotonin, presumably by attenuating the release or response to relaxing factor(s). In the aorta of the spontaneously hypertensive rat, the endothelium releases a constricting factor in response to acetylcholine. Pulmonary arterial endothelium (and other vessels) releases a vasoconstrictor that is blocked by inhibitors of cyclooxygenase. It is not clear whether this pressor factor is thromboxane A2. Cultured endothelial cells release a polypeptide that contracts arteries; however, any relation to hypertension is not known.
Peach
M J
MJ
Department of Pharmacology, University of Virginia School of Medicine, Charlottesville 22908.
Loeb
A L
AL
D000208:Acute Disease; D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D002455:Cell Division; D002908:Chronic Disease; D004247:DNA / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D006493:Heparin / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000378:metabolism* / Q000473:pathology; D010539:Permeability; D011453:Prostaglandins / Q000378:metabolism
D000227:Adenine Nucleotides; D001679:Biogenic Amines; D011453:Prostaglandins; D006493:Heparin; D004247:DNA