Intracerebroventricular dopamine attenuates sodium-induced but not angiotensin-induced drinking in minipigs.
Drinking in response to dopamine (100 micrograms) injected into the lateral cerebral ventricles (i.c.v.), alone, or together with angiotensin II (AII, 300 ng) or hypertonic NaCl (1.4 Osm) was studied in water-replete minipigs trained to obtain their water under operant conditions. Dopamine itself was ineffective at producing drinking and it did not affect AII-induced drinking. Drinking in response to hypertonic NaCl was significantly attenuated by dopamine. Therefore in minipigs angiotensin-induced drinking does not appear to operate through a dopaminergic mechanism whereas sodium-induced drinking does.
Thornton
S N
SN
Sharman
D F
DF
Baldwin
B A
BA
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects*; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology*; D013552:Swine; D013556:Swine, Miniature
D012462:Saline Solution, Hypertonic; D000804:Angiotensin II; D012965:Sodium Chloride; D004298:Dopamine