title: Inhibition of purified Escherichia coli leader peptidase by the leader (signal) peptide of bacteriophage M13 procoat.
abstract: The leader peptide of bacteriophage M13 procoat inhibited the cleavage of M13 procoat or pre-maltose-binding protein by purified Escherichia coli leader peptidase. This finding confirms inferences that the leader is the primary site of enzyme recognition and suggests a rationale for the rapid hydrolysis of leader peptides in vivo.
authors.forename: W
authors.initials: W
authors.lastname: Wickner
authors.forename: K
authors.initials: K
authors.lastname: Moore
authors.forename: N
authors.initials: N
authors.lastname: Dibb
authors.forename: D
authors.initials: D
authors.lastname: Geissert
authors.forename: M
authors.initials: M
authors.lastname: Rice
mesh_terms: D018528:ATP-Binding Cassette Transporters; D002213:Capsid / Q000378:metabolism*; D036022:Capsid Proteins; D002352:Carrier Proteins / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology*; D029968:Escherichia coli Proteins; D058619:Maltose-Binding Proteins; D008565:Membrane Proteins; D009004:Monosaccharide Transport Proteins; D011480:Protease Inhibitors; D011498:Protein Precursors / Q000378:metabolism*; D021382:Protein Sorting Signals / Q000378:metabolism / Q000494:pharmacology*; D012697:Serine Endopeptidases
chemical_list: D018528:ATP-Binding Cassette Transporters; D036022:Capsid Proteins; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D058619:Maltose-Binding Proteins; D008565:Membrane Proteins; D009004:Monosaccharide Transport Proteins; D011480:Protease Inhibitors; D011498:Protein Precursors; D021382:Protein Sorting Signals; C025668:coat protein, Bacteriophage M13; C461599:maltose transport system, E coli; D010450:Endopeptidases; D012697:Serine Endopeptidases; C026515:type I signal peptidase