title: Controlled evaluation of nabumetone in the treatment of active adult rheumatoid arthritis. Nabumetone versus naproxen double-blind parallel study.
abstract: Nabumetone is a new nonsteroidal anti-inflammatory agent. Therapy with nabumetone 1,000 mg given at bedtime was compared with naproxen 250 mg given twice daily in a prospective double-blind study of patients with rheumatoid arthritis. Both drugs were found to be efficacious in a comparable fashion. Both drugs were well tolerated in terms of patient withdrawal rates, which were 5 and 8 percent, respectively. Gastrointestinal side effects were the most commonly encountered problem. Nabumetone holds promise as an important new therapeutic approach in arthritis.
authors.affiliation: Department of Internal Medicine, University of South Florida College of Medicine, Tampa 33612.
authors.forename: F B
authors.initials: FB
authors.lastname: Vasey
authors.forename: B F
authors.initials: BF
authors.lastname: Germain
authors.forename: L R
authors.initials: LR
authors.lastname: Espinoza
authors.forename: P
authors.initials: P
authors.lastname: Box
authors.forename: B I
authors.initials: BI
authors.lastname: Bockow
authors.forename: J A
authors.initials: JA
authors.lastname: Lipani
authors.forename: B J
authors.initials: BJ
authors.lastname: Mullen
authors.forename: A L
authors.initials: AL
authors.lastname: Brodsky
authors.forename: R M
authors.initials: RM
authors.lastname: Fleischmann
authors.forename: R A
authors.initials: RA
authors.lastname: Fogari
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002074:Butanones / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077430:Nabumetone; D009288:Naproxen / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002074:Butanones; D009288:Naproxen; D000077430:Nabumetone