Pathogenesis of the mucosal hyperplasia in self-filling blind loops of rat jejunum: a morphometric study in germ free animals.
Bacterial overgrowth and high intraluminal concentrations of deconjugated bile acids are thought to be responsible for mucosal hyperplasia in self-filling blind loops of rat jejunum. To investigate this hypothesis further we have assessed the three dimensional architecture of these loops created in germ free animals without or with di- or mono-association of different bacterial species. It was found that mucosal hyperplasia develops in the absence of any bacterial contamination and that bacterial association does not lead to a more pronounced mucosal proliferation. This implies that other mechanisms provoke this morphological phenomenon. Increased bulk contents in these loops or immunological events are probably the most likely explanation.
Menge
H
H
Klinikum Steglitz, Abteilung für innere Medizin mit Schwerpunkt Gastroenterologie, Freie Universität, Berlin, FRG.
Germer
C T
CT
Stössel
R
R
Simes
G
G
Hahn
H
H
Riecken
E O
EO
D000818:Animals; D001439:Bacteroides / Q000254:growth & development; D001765:Blind Loop Syndrome / Q000382:microbiology / Q000473:pathology*; D004926:Escherichia coli / Q000254:growth & development; D006965:Hyperplasia / Q000209:etiology / Q000382:microbiology; D007413:Intestinal Mucosa / Q000382:microbiology / Q000473:pathology*; D007583:Jejunum / Q000382:microbiology / Q000473:pathology*; D007778:Lactobacillus / Q000254:growth & development; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains