title: Influence of sialomucin at the resection margin on local tumour recurrence and survival of patients with colorectal cancer: a multivariate analysis.
abstract: In a multicentre prospective trial 358 patients undergoing curative surgery for colorectal cancer were followed for a median 18.0 months (+/- 7.2 months). The presence or absence of sialomucin in either resection margin was studied using the high iron diamine-alcian blue stain. There was evidence of excess sialomucin at one or other resection margin in 106 patients (29.6 per cent). Apart from sigmoid carcinomas occurring more often in the sialomucin positive group, there were no significant differences in any histological or clinical parameters between groups. Survival analysis for the events 'death', 'local recurrence', and 'all recurrence' was undertaken using the Cox regression model. The best prognostic variables selected in a stepwise fashion for death and all recurrence were 'Dukes' classification', 'sialomucin present' and 'histological differentiation'. The best prognostic variables selected for local recurrence were 'sialomucin present', 'Dukes' classification' and 'histological differentiation'. Sialomucin in a resection margin is an important independent prognostic variable for the development of local tumour recurrence and of subsequent survival for patients with colorectal carcinoma.
authors.forename: P M
authors.initials: PM
authors.lastname: Dawson
authors.forename: N A
authors.initials: NA
authors.lastname: Habib
authors.forename: H C
authors.initials: HC
authors.lastname: Rees
authors.forename: R C
authors.initials: RC
authors.lastname: Williamson
authors.forename: C B
authors.initials: CB
authors.lastname: Wood
mesh_terms: D000368:Aged; D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000401:mortality; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D009077:Mucins / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000401:mortality; D011379:Prognosis; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000378:metabolism* / Q000401:mortality; D052116:Sialomucins
chemical_list: D009077:Mucins; D052116:Sialomucins