title: Bronchial responsiveness to methacholine: relation to respiratory symptoms and pulmonary function.
abstract: A methacholine bronchial provocation test was administered to 290 subjects obtained from the 1,900 male volunteers participating in the Normative Aging Study. A positive response (less than 20% decline in FEV1) was obtained in 83 subjects. A positive response was associated with current smoking, presence of wheeze and reduced FEV1. Bronchial responsiveness, cigarette smoking, normal subjects, FEV1.
authors.affiliation: Normative Aging Study, VA Outpatient Clinic, Boston, Ma.
authors.forename: D
authors.initials: D
authors.lastname: Sparrow
authors.forename: G
authors.initials: G
authors.lastname: O'Connor
authors.forename: S T
authors.initials: ST
authors.lastname: Weiss
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D001900:Boston; D001980:Bronchi / Q000187:drug effects*; D001982:Bronchial Diseases / Q000453:epidemiology*; D001985:Bronchial Provocation Tests; D003430:Cross-Sectional Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008448:Maximal Expiratory Flow Rate; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000494:pharmacology*; D008875:Middle Aged; D012907:Smoking
chemical_list: D008688:Methacholine Compounds; D016210:Methacholine Chloride