B-cell chronic lymphocytic leukaemia with aberrant expression of CD8 antigen.
The monoclonal antibodies against CD8 (T suppressor/cytotoxic) antigen (Leu2/OKT8) were found to bind to leukaemic lymphocytes from a patient with chronic lymphocytic leukaemia. The cells also had an unusual type of rod-like cytoplasmic immunoglobulin of IgM/lambda type as seen by light, fluorescence and electron microscopy, and displayed several antigens characteristic for B lymphocytes. Gene rearrangement analysis showed rearrangement of mu heavy chain gene. In spite of an expression of CD8 antigen, T-cell receptor genes were not rearranged.
Porwit
A
A
Division of Haematology, Karolinska Hospital, Stockholm, Sweden.
Borgonovo
L
L
Osby
E
E
Lenkei
R
R
Smith
C I
CI
Hammarström
L
L
D000368:Aged; D000951:Antigens, Neoplasm / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D001345:Autoradiography; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000276:immunology*; D016169:Lymphocyte Function-Associated Antigen-1
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D016169:Lymphocyte Function-Associated Antigen-1