Monitoring cyclic antidepressants.
Therapeutic drug monitoring of antidepressants can ensure that a reasonable amount of drug reached the circulation, can aid in dosage adjustments for treating endogenous depression, can avoid toxicity, and aid in the diagnosis of drug-induced delirium. This article reviews the justification for antidepressant monitoring, discusses sample collection procedures, and presents guidelines for the interpretation of data.
DeVane
C L
CL
Colleges of Pharmacy and Medicine, University of Florida, Gainesville.
D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects / Q000145:classification / Q000493:pharmacokinetics*; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic