Sporozoite-induced infections of the Salvador I strain of Plasmodium vivax in Saimiri sciureus boliviensis monkeys.
Twenty Saimiri sciureus boliviensis monkeys from Bolivia were inoculated intravenously with sporozoites of the Salvador I strain of Plasmodium vivax. All animals were splenectomized 7 days after inoculation. Inoculation of 100,000 sporozoites resulted in prepatent periods averaging 16.6 days; all monkeys developed high-level parasitemias with an average maximum of 103,000 per mm3. Inoculation of 10,000 sporozoites resulted in average prepatent periods of 19.4 days; one of the resulting infections produced a transient low-level parasitemia. Of 5 monkeys inoculated with 1,000 sporozoites, 4 had prepatent periods of from 24 to 35 days and 1 failed to demonstrate any parasitemia; 1 monkey supported a low-level transient parasitemia, whereas the other 3 monkeys had high-level parasitemias. It is proposed that by using a minimum inoculum of 10,000 sporozoites, the model system may be useful in the testing of anti-sporozoite vaccines directed against P. vivax.
Collins
W E
WE
Malaria Branch, Center for Infectious Diseases, Atlanta, Georgia 30333.
Skinner
J C
JC
Pappaioanou
M
M
Broderson
J R
JR
Filipski
V K
VK
McClure
H M
HM
Strobert
E
E
Sutton
B B
BB
Stanfill
P S
PS
Huong
A Y
AY
D000818:Animals; D000852:Anopheles; D004195:Disease Models, Animal; D008288:Malaria / Q000097:blood / Q000469:parasitology*; D010966:Plasmodium vivax / Q000254:growth & development; D012453:Saimiri