title: Reversal of renovascular hypertension: role of the renal medulla.
abstract: The fall in blood pressure, which occurs when renovascular hypertension is corrected surgically, offers a means of elucidating the factors responsible for blood pressure control. When Goldblatt two-kidney, one-clip hypertension in the rat is reversed by unclipping the renal artery, or by removal of the ischaemic kidney, restoration of normal blood pressure is due to a fall in peripheral resistance. This is associated with sodium retention and cannot be modified by inhibition of the renin-angiotensin system. The fall is, however, partially inhibited by chemical removal of the renal medulla by means of 2-bromo-ethylamine hydrobromide. When normal rats are chemically medullectomized, moderate hypertension is produced, which cannot be attributed to the renin-angiotensin system or sodium retention. It is concluded that a renomedullary vasodepressor system is ablated by chemical medullectomy: further, this system plays a role in the surgical correction of Goldblatt hypertension.
authors.affiliation: Department of Medicine, University of Leicester, U.K.
authors.forename: J D
authors.initials: JD
authors.lastname: Swales
authors.forename: R F
authors.initials: RF
authors.lastname: Bing
authors.forename: M E
authors.initials: ME
authors.lastname: Edmunds
authors.forename: G I
authors.initials: GI
authors.lastname: Russell
authors.forename: H
authors.initials: H
authors.lastname: Thurston
mesh_terms: D000818:Animals; D001794:Blood Pressure; D006339:Heart Rate; D006978:Hypertension, Renovascular / Q000503:physiopathology* / Q000628:therapy; D007679:Kidney Medulla / Q000503:physiopathology*; D009392:Nephrectomy; D051381:Rats; D012079:Renal Circulation; D012083:Renin / Q000097:blood; D014655:Vascular Resistance
chemical_list: D012083:Renin