title: [Lines of transformed murine thymus cells. I. Production of the lines].
abstract: Supernatant of activated cells of human T-leucosis line "Jurkat" enriched with interleukin-2 (IL-2) was injected to Balb/c mice. After a number of injections the animals were sacrificed and the thymus cells were cultured in vitro. Transformed cell clones were formed on days 3-4. Two stable T-cell strains of the reproduced primary cells were obtained (TC.SC-1/1.1. and TC.SC-1/2.0). The strains corresponded to the transitional stage of pre-T-lymphocytes and consisted of tumour cells. A possible mechanism of malignant transformation of these cells is discussed.
authors.forename: V P
authors.initials: VP
authors.lastname: Shichkin
authors.forename: A A
authors.initials: AA
authors.lastname: Iarilin
authors.forename: O P
authors.initials: OP
authors.lastname: Terekhov
mesh_terms: D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000473:pathology*; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology; D007938:Leukemia / Q000473:pathology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D013601:T-Lymphocytes / Q000637:transplantation; D013950:Thymus Gland / Q000166:cytology* / Q000187:drug effects; D013997:Time Factors
chemical_list: D007376:Interleukin-2
vernacular_title: Linii transformirovannykh kletok timusa myshi. I. Poluchenie liniĭ.