title: Ceftazidime in antibiotic prophylaxis for emergency cesarean section: a randomized prospective study.
abstract: The efficacy of two randomized antibiotic prophylactic schedules with ceftazidime (group A: single preoperative 2 g intramuscular dose; group B: 3 perioperative 1 g intramuscular doses every 6 h) was evaluated in 200 pregnant women undergoing cesarean section. Postoperative complications were observed in 9 cases (4 in group A and 5 in group B; p = NS). Analysis of possible risk factors revealed 1) a relationship between postoperative morbidity and overweight (body mass index above 30) in group A only; 2) a possible contributory effect of duration of labor (more than 6 h) in group A; and 3) a possible effect of duration of rupture of the membranes (more than 6 h) in group B only. The results obtained lead to the conclusion that single-dose prophylaxis with ceftazidime is as effective as short-term 3-dose ceftazidime prophylaxis in preventing post-cesarean complications.
authors.affiliation: Department of Obstetrics and Gynecology, University of Brescia, Italy.
authors.forename: P G
authors.initials: PG
authors.lastname: Tassi
authors.forename: M
authors.initials: M
authors.lastname: Tarantini
authors.forename: G P
authors.initials: GP
authors.lastname: Cadenelli
authors.forename: A
authors.initials: A
authors.lastname: Gastaldi
authors.forename: M
authors.initials: M
authors.lastname: Benedetti
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000517:prevention & control*; D002442:Ceftazidime / Q000008:administration & dosage / Q000627:therapeutic use*; D002585:Cesarean Section; D004334:Drug Administration Schedule; D004630:Emergencies; D005260:Female; D006801:Humans; D011247:Pregnancy; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D002442:Ceftazidime