CV-1, a new antibiotic produced by a strain of Streptomyces sp. I. Fermentation, isolation and biological properties of the antibiotic.
A new antibiotic, CV-1, was isolated from the culture broth of a Streptomyces sp. by various chromatographies. CV-1 showed antibacterial activity against Escherichia coli in cooperation with spiramycin, a macrolide antibiotic. The mode of action of CV-1 seemed to be the inhibition of lipopolysaccharide synthesis.
Ichimura
M
M
Koguchi
T
T
Yasuzawa
T
T
Tomita
F
F
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D002845:Chromatography; D004347:Drug Interactions; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D005285:Fermentation; D005944:Glucosamine / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D007933:Leucomycins / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000096:biosynthesis; D013302:Streptomyces / Q000378:metabolism*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D007933:Leucomycins; D008070:Lipopolysaccharides; C053067:1,2-diamino-1,2-N,N'-carbonyl-1,2-dideoxyglucose hydrate; D005944:Glucosamine