title: [Decreased sensitivity to the hypoglycemic action of insulin in animals with a lowered blood heparin concentration].
abstract: It has been shown that in animals with reduced heparin blood concentration the hypoglycemic insulin action was considerably low. This was established for rats with alloxan diabetes and ageing rats with depressed anticoagulation system and atherosclerosis enhanced by prolonged atherogenic diet. With insulin injection (0.2-0.3 U/200 g), blood sugar concentration in such animals was 2-2.5 times lower than in normal ones. The compensation of endogenous heparin deficiency by an intravenous injection of heparin normalizes the reaction of animals to exogenous insulin.
authors.forename: A M
authors.initials: AM
authors.lastname: Ul'ianov
authors.forename: F B
authors.initials: FB
authors.lastname: Shapiro
authors.forename: G G
authors.initials: GG
authors.lastname: Bazaz'ian
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D004036:Diet, Atherogenic; D006493:Heparin / Q000097:blood* / Q000494:pharmacology; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced*; D007328:Insulin / Q000494:pharmacology*; D007330:Insulin Antibodies / Q000032:analysis; D007333:Insulin Resistance; D008297:Male; D051381:Rats
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007330:Insulin Antibodies; D006493:Heparin
vernacular_title: Snizhenie chuvstvitel'nosti k gipoglikemicheskomu deĭstviiu insulina u zhivotnykh s ponizhennoĭ kontsentratsieĭ geparina v krovi.