Regulation of metabolite fluxes and concentrations in living cells and organisms.
A quantitative framework for the analysis of metabolic control depends on the recognition of input and output fluxes occurring in steady-state systems in which the concentrations of intermediates are constant--the fluxes and concentrations peculiar to a given steady state are determined by the catalytic components of the system. Control of the variables is a global function shared among the components in a complex pattern, for reasons which are evident when the detailed properties of such systems are analysed. Such properties include circuit design and a host of factors affecting the sensitivity of catalytic components to substrates and effectors.
Gevers
W
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Department of Medical Biochemistry, University of Cape Town.
D002463:Cell Membrane Permeability; D004789:Enzyme Activation; D008660:Metabolism; D008954:Models, Biological