Impaired glucose metabolism in heroin and methadone users.
Plasma glucose and insulin responses to both oral and intravenous glucose stimulation were evaluated in heroin and methadone addicts, compared to healthy control subjects. Both groups of addicts had an altered response to oral and intravenous glucose load. These phenomena were linked to a reduced insulin response. Moreover, increased fasting insulin levels in both groups of addicts were observed. These data show that both heroin and methadone addiction may alter glucose metabolism, and, furthermore, stress the findings of similarities between opiate addicts and non-insulin dependent diabetics.
Ceriello
A
A
Istituto di Clinica Medica, I Facoltà di Medicina, Università di Napoli, Italy.
Giugliano
D
D
Passariello
N
N
Quatraro
A
A
Dello Russo
P
P
Torella
R
R
D'Onofrio
F
F
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006556:Heroin Dependence / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007328:Insulin; D008297:Male; D008691:Methadone; D009293:Opioid-Related Disorders / Q000097:blood / Q000378:metabolism*
D001786:Blood Glucose; D007328:Insulin; D008691:Methadone