title: Topological properties of DNA domains and interaction with RNA polymerase II.
abstract: We have analyzed the relationship between the alterations of the DNA structure induced by topological constraint and the template properties of promoters in vitro. A cause-effect relationship has been defined in several instances. Experimental protocols have been developed for the study of the topological properties of RNA polymerase II promoters. The goal of these studies is the definition of the intrinsic structural informations of DNA.
authors.affiliation: Dipartimento Genetica e Biologia Molecolare Facoltà Scienze Università La Sapienza, Roma, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Negri
authors.forename: F
authors.initials: F
authors.lastname: Della Seta
authors.forename: A G
authors.initials: AG
authors.lastname: Ficca
authors.forename: G
authors.initials: G
authors.lastname: Camilloni
authors.forename: E
authors.initials: E
authors.lastname: Di Mauro
mesh_terms: D004247:DNA / Q000378:metabolism*; D004278:DNA, Superhelical; D009690:Nucleic Acid Conformation; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000378:metabolism*; D012045:Regulatory Sequences, Nucleic Acid; D012441:Saccharomyces cerevisiae / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D004278:DNA, Superhelical; D004247:DNA; D012319:RNA Polymerase II