MC29 deletion mutants which fail to transform chicken macrophages are competent for transformation of quail macrophages.
A number of MC29 mutants with deleted myc genes have been previously characterized. Many of these mutants have been found to be defective for transformation of chicken macrophages in vitro and for tumor induction in chickens. Such mutants are capable of transforming Japanese quail macrophages in vitro and inducing a high incidence of tumors in Japanese quail. Thus, Japanese quail may contain a factor(s) capable of complementing the defective transforming proteins encoded by some deleted v-myc genes.
Biegalke
B J
BJ
Heaney
M L
ML
Bouton
A
A
Parsons
J T
JT
Linial
M
M
D000818:Animals; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D002645:Chickens / Q000382:microbiology*; D003370:Coturnix / Q000382:microbiology*; D004273:DNA, Neoplasm / Q000032:analysis; D003673:Defective Viruses / Q000235:genetics* / Q000502:physiology; D005347:Fibroblasts / Q000382:microbiology; D008264:Macrophages / Q000382:microbiology*; D009154:Mutation; D009374:Neoplasms, Experimental / Q000209:etiology / Q000235:genetics; D016274:Oncogene Protein p55(v-myc); D011784:Quail / Q000382:microbiology*; D012191:Retroviridae Proteins / Q000235:genetics; D013045:Species Specificity
D004273:DNA, Neoplasm; D016274:Oncogene Protein p55(v-myc); D012191:Retroviridae Proteins