title: [Value of exchange transfusion in the treatment of severe malaria (apropos of 5 cases)].
abstract: Five imported falciparum malaria cases with severe evolution are reported. Treatment associated a blood exchange transfusion and an antimalaria chemotherapy (mefloquine in three patients and quinine in two patients). All patients were successfully cured despite of serious visceral complications occurring in two patients (pulmonary and cerebral oedema). Technical management of treatment is detailed. Exchange transfusion should be considered in falciparum malaria when parasitaemia overcomes 20% and when serious visceral impairment, hemolysis or consumption coagulopathy are occurring.
authors.affiliation: Service de Médecine Interne et Tropicale, Hôpital Saint-André, Bordeaux.
authors.forename: P
authors.initials: P
authors.lastname: Lataste
authors.forename: G
authors.initials: G
authors.lastname: Soubiran
authors.forename: A
authors.initials: A
authors.lastname: Nlend
authors.forename: M
authors.initials: M
authors.lastname: Le Bras
authors.forename: R
authors.initials: R
authors.lastname: Roue
authors.forename: C
authors.initials: C
authors.lastname: Wone
authors.forename: J C
authors.initials: JC
authors.lastname: Ragnaud
authors.forename: A
authors.initials: A
authors.lastname: Buil
authors.forename: M C
authors.initials: MC
authors.lastname: Briand
authors.forename: C
authors.initials: C
authors.lastname: Ripert
mesh_terms: D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D015767:Mefloquine; D008875:Middle Aged; D010963:Plasmodium falciparum; D011803:Quinine / Q000627:therapeutic use; D011804:Quinolines / Q000627:therapeutic use
chemical_list: D000962:Antimalarials; D011804:Quinolines; D011803:Quinine; D015767:Mefloquine
vernacular_title: Intérêt de l'exsanguinotransfusion dans le traitement du paludisme grave (à propos de 5 observations).