Morphological transformation and tumorigenicity in C3H/10T1/2 cells transformed with an inducible c-Ha-ras oncogene.
A C3H/10T1/2 cell line containing an inducible metallothionein-ras hybrid oncogene was conditionally and reversibly transformed upon exposure to zinc ions. Interestingly, although the cell line was fully malignant when expressing only low levels of ras, complete morphological transformation required much higher levels.
Trimble
W S
WS
Department of Medical Genetics, University of Toronto, Ontario, Canada.
Boulianne
G L
GL
Hozumi
N
N
D000818:Animals; D002448:Cell Adhesion; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D005796:Genes; D011905:Genes, ras; D008668:Metallothionein / Q000235:genetics; D051379:Mice; D008809:Mice, Inbred C3H; D008819:Mice, Nude; D011401:Promoter Regions, Genetic; D011519:Proto-Oncogenes
D008668:Metallothionein