The hypotensive effect of captopril is not mediated by renal medullary lipids.
The role of renomedullary lipids in the hypotensive effect of captopril was studied in spontaneously hypertensive rats, one-kidney, one clip hypertensive rats and two-kidney, one clip hypertensive rats using inhibitors of acetyl glyceryl ether phosphorylcholine and prostaglandins, and chemical medullectomy. Our experiments indicate that it is unlikely that renomedullary lipids contribute to the hypotensive action of captopril.
Saeki
S
S
Ogihara
T
T
Masugi
F
F
Kumahara
Y
Y
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006977:Hypertension, Renal / Q000188:drug therapy*; D007213:Indomethacin / Q000494:pharmacology; D007679:Kidney Medulla / Q000502:physiology*; D008055:Lipids / Q000502:physiology*; D051381:Rats; D011918:Rats, Inbred SHR
D008055:Lipids; D002216:Captopril; D007213:Indomethacin