title: The human hematopoietic colony-stimulating factors.
abstract: The complementary DNAs and genes encoding the four major human myeloid growth factors--granulocyte colony-stimulating factor, macrophage colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and interleukin-3--have all been molecularly cloned. These DNA clones have proved valuable for studying the molecular biology of these important regulatory molecules as well as for the large-scale production of the recombinant growth factor proteins. These advances have led to a much better understanding of the role of the myeloid growth factors in regulating hematopoiesis in vivo that should soon find practical application in clinical medicine.
authors.forename: S C
authors.initials: SC
authors.lastname: Clark
authors.forename: R
authors.initials: R
authors.lastname: Kamen
mesh_terms: D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D006098:Granulocytes / Q000166:cytology; D006801:Humans; D007377:Interleukin-3 / Q000235:genetics / Q000502:physiology / Q000627:therapeutic use; D008264:Macrophages / Q000166:cytology; D011994:Recombinant Proteins
chemical_list: D007377:Interleukin-3; D011994:Recombinant Proteins