[Characteristics of endocrine disorders in the early stages of the development of chronic experimental pancreatitis].
The experiments on normal mongrel dogs and those with chronic experimental pancreatitis were performed to reveal the early changes of the endocrine pancreas function. The concentration of immunoreactive insulin and glucagon were studied in afferent vessels of the organ after intraarterial glucose-loading during pancreatic perfusion in situ. The data obtained have shown that in chronic pancreatitis the maximum secretion of insulin is decreased and delayed, as compared to normal animals. At the same time insulin-glucagon secretion ratio remains unchanged. That was indicative of the normal alpha-cell function at the early stages of the disease.
Vladimiro
V G
VG
Podotykina
O I
OI
Zhuravlev
A G
AG
Sukhanov
L D
LD
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002908:Chronic Disease; D004285:Dogs; D004700:Endocrine System Diseases / Q000097:blood / Q000209:etiology* / Q000473:pathology; D005934:Glucagon / Q000097:blood / Q000378:metabolism; D005947:Glucose / Q000008:administration & dosage; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism / Q000473:pathology; D010195:Pancreatitis / Q000097:blood / Q000209:etiology* / Q000473:pathology; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D005947:Glucose
Kharakteristika éndokrinnykh narusheniĭ na rannikh étapakh razvitiia éksperimental'nogo khronicheskogo pankreatita.