Protection by phospholipids of Schistosoma mansoni schistosomula against the action of cytotoxic antibodies and complement.
Schistosoma mansoni schistosomula cultured in the presence of phospholipids showed a decreased sensitivity to the lethal complement-mediated action of anti-schistosome antibodies. Phosphatidyl choline, sphingomyelin and phosphatidyl ethanolamine had a protective action on the schistosomula transformed in vitro by passage through the skin or by a mechanical procedure. Phosphatidyl choline acted regardless of its fatty acid composition. Phosphatidyl serine and phosphatidic acid did not protect. Thus, it appears that phospholipids can play a role in parasite resistance to immune attack by cytotoxic antibodies and complement, and that this role is specific to certain phospholipid types.
Billecocq
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Unité de Biochimie des Antigènes, Institut Pasteur, Paris, France.
D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D002784:Cholesterol / Q000494:pharmacology; D003165:Complement System Proteins / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D007106:Immune Sera / Q000276:immunology; D010712:Phosphatidic Acids / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology; D010714:Phosphatidylethanolamines / Q000494:pharmacology; D010718:Phosphatidylserines / Q000494:pharmacology; D010743:Phospholipids / Q000494:pharmacology*; D012550:Schistosoma mansoni / Q000276:immunology*; D013109:Sphingomyelins / Q000494:pharmacology
D000909:Antibodies, Helminth; D000954:Antigens, Surface; D007106:Immune Sera; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010718:Phosphatidylserines; D010743:Phospholipids; D013109:Sphingomyelins; D003165:Complement System Proteins; D002784:Cholesterol