A role for platelet activating factor and platelets in the induction of bronchial hyperreactivity.
Platelet activating factor (PAF) is able to induce a long-lasting non-specific increase in bronchial hyperreactivity in both experimental animals and man. In the guinea-pig, PAF-induced bronchial hyperreactivity is secondary to platelet activation and associated with a recruitment of platelets into the lung. As platelets have been shown to be activated in clinical asthma and platelet abnormalities are a feature of this disease, it would seem justified to evaluate further the role of PAF and platelets in the induction of the bronchial hyperreactivity which characterizes asthma.
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D000818:Animals; D001249:Asthma / Q000209:etiology*; D001792:Blood Platelets / Q000502:physiology*; D001980:Bronchi / Q000503:physiopathology*; D004804:Eosinophils / Q000502:physiology; D006801:Humans; D008407:Mast Cells / Q000502:physiology; D010972:Platelet Activating Factor / Q000502:physiology*
D010972:Platelet Activating Factor