Anaphylactoid and anti-ovulatory activities of LHRH antagonists in rats.
Studies were conducted with LHRH antagonists examining the relationship of structure to anaphylactoid-like activity and the relationship of anaphylactoid-like activity to anti-ovulatory activity in rats. Substitution of basic amino acids appeared to enhance the anaphylactoid-like activity of these peptides but other complex structural characteristics may also be involved. Anaphylactoid and anti-ovulatory activities were clearly independent and potent LHRH antagonists with minimal anaphylactoid-like activity were identified.
Phillips
A
A
Research Laboratories, Ortho Pharmaceutical Corp., Raritan, NJ 08869.
Hahn
D W
DW
Capetola
R J
RJ
Bishop
C
C
McGuire
J L
JL
D000595:Amino Acid Sequence; D000707:Anaphylaxis / Q000139:chemically induced*; D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D010060:Ovulation / Q000187:drug effects*; D011359:Proestrus; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D007987:Gonadotropin-Releasing Hormone