Diet composition and lipoprotein lipase (EC 3.1.1.34) activity in human obesity.
1. Adipose tissue lipoprotein lipase (EC 3.1.1.34; AT-LPL), a rate-limiting enzyme in triglyceride storage in adipose tissue, is hormonally regulated and may be important in the maintenance of obesity. 2. In twelve obese women, AT-LPL activity was measured before weight loss, during weight loss and after 1 and 2 weeks of weight maintenance on either a high-carbohydrate or a high-protein diet. 3. When related to tissue weight, AT-LPL activity during the 2 weeks of weight maintenance was higher than the initial AT-LPL activity; there was no difference when activity was expressed per cell. 4. Changes in AT-LPL activity were not affected by diet composition. AT-LPL activity correlated with insulin levels and a change in insulin sensitivity of AT-LPL was observed after weight loss.
Smolin
L A
LA
Grosvenor
M B
MB
Handelsman
D J
DJ
Brasel
J A
JA
D000273:Adipose Tissue / Q000201:enzymology*; D000328:Adult; D001835:Body Weight; D004038:Diet, Reducing; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008071:Lipoprotein Lipase / Q000378:metabolism*; D009765:Obesity / Q000097:blood / Q000178:diet therapy / Q000201:enzymology*
D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D007328:Insulin; D008071:Lipoprotein Lipase