[Cytotoxicity of bile acids and lysolecithin--a factor in the pathogenesis of stomach ulcer?].
The role of bile acids and lysolecithin in the pathogenesis of peptic ulcer is as yet not unequivocally defined. Based on the physiochemical properties of bile acids and animal experiments they have damaging potential on the mucosal cell. However, the majority of results reported in patients do not favour a significant role of bile acids in the pathogenesis of peptic ulcer. With regard to lysolecithin a sufficient data base is missing. Based on the damaging potential in animal experiments and the few reported patient studies a role in pathogenesis is more probable than for bile acids. Studies on concentrations and effects of both, bile acids and lysolecithin over prolonged periods of time in patients with ulcer disease are necessary to further clarify their role in pathogenesis of ulcer disease.
Schölmerich
J
J
Medizinische Universitätsklinik Freiburg.
D000818:Animals; D001647:Bile Acids and Salts / Q000502:physiology*; D001655:Bile Reflux / Q000503:physiopathology; D002470:Cell Survival; D004383:Duodenogastric Reflux / Q000503:physiopathology; D005753:Gastric Mucosa / Q000503:physiopathology; D006801:Humans; D008244:Lysophosphatidylcholines / Q000502:physiology*; D013276:Stomach Ulcer / Q000209:etiology*
D001647:Bile Acids and Salts; D008244:Lysophosphatidylcholines
Zytotoxizität von Gallensäuren und Lysolecithin--ein Faktor in der Pathogenese des Ulcus ventriculi?