Effect of the calcium antagonist nilvadipine on haemodynamics at rest and during cold stimulation in essential hypertension.
The immediate haemodynamic effects of the calcium antagonist nilvadipine have been studied in ten patients with established mild essential hypertension. Nilvadipine 4 mg p.o. reduced both the systolic and diastolic blood pressures within 60 min, associated with a fall in total peripheral resistance and an increase in heart rate and cardiac index. The peak of blood pressure and total peripheral resistance reached during a cold pressor test were reduced by nilvadipine, but it did not affect the haemodynamic responsiveness to cold stimulation. Plasma renin activity was unaltered and the plasma noradrenaline concentration was increased only slightly. Thus, nilvadipine lowered blood pressure at rest and during cold stimulation as a result of arteriolar dilatation. The hypotensive effect at rest was associated with a reflex increase in heart rate and cardiac index.
Takabatake
T
T
First Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
Yamamoto
Y
Y
Nakamura
S
S
Hashimoto
N
N
Satoh
S
S
Yamada
Y
Y
Ohta
H
H
Hattori
N
N
D000328:Adult; D000368:Aged; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002395:Catecholamines / Q000097:blood; D003080:Cold Temperature; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D012083:Renin / Q000097:blood; D014655:Vascular Resistance / Q000187:drug effects
D002121:Calcium Channel Blockers; D002395:Catecholamines; C035100:nilvadipine; D012083:Renin; D009543:Nifedipine