[Chlorambucil pulse therapy in progressive chronic polyarthritis. Initial results of an open multicenter study].
The first preliminary clinical results with chlorambucil pulse-therapy in patients with refractory rheumatoid arthritis are reported, with a dose of chlorambucil below that which might risk inducing leukaemia. The clinical response was good in 15 out of 19 patients; symptoms and objective findings of rheumatoid arthritis had significantly improved. However, multiple toxic reactions have been identified in our patients.
Aeschlimann
A
A
Rheumatologische Universitätsklinik Basel, Schweiz.
Brackertz
D
D
Kaiser
H
H
Müller
W
W
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002699:Chlorambucil / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D002699:Chlorambucil
Chlorambucil-Stosstherapie bei progressiver chronischer Polyarthritis. Erste Ergebnisse einer offenen multizentrischen Studie.