Chronic lymphocytic leukaemia: case control epidemiological study in Yorkshire.
This is the second report of a large case control study of lymphoma/leukaemia occurring in Yorkshire during 1979-84, and deals with chronic lymphocytic leukaemia presenting either in its haematological (CLL) or more solid lymphomatous (malignant lymphoma-lymphocytic or MLL) forms. In all, 330 cases and 561 controls were interviewed. The results support the concept that CLL/MLL is a condition of multiple aetiologies with evidence for genetic predisposition through an excess of family cases, immune perturbation demonstrated by excessive previous skin diseases and phenylbutazone use, and viral involvement shown by links with infectious diseases and multiple sclerosis.
Cartwright
R A
RA
Bernard
S M
SM
Bird
C C
CC
Darwin
C M
CM
O'Brien
C
C
Richards
I D
ID
Roberts
B
B
McKinney
P A
PA
D064420:Drug-Related Side Effects and Adverse Reactions; D004739:England; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D007945:Leukemia, Lymphoid / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D008297:Male; D011878:Radiotherapy / Q000009:adverse effects; D012306:Risk; D012871:Skin Diseases / Q000150:complications