[Characteristics of copper-induced streptomycin transport in Escherichia coli].
Copper dependent uptake of streptomycin by resting E. coli cells was studied. It was shown that copper stimulates the aminoglycoside uptake only when bacteria possess endogenic energy sources. Additional accumulation of positive charged molecules of the antibiotic is accompanied by partial depolarisation of the membrane, its steady state distribution between cells and the medium corresponding to the resulted value of the membrane potential. On the basis of the data obtained it was suggested that under the influence of copper membrane permeability for streptomycin increases.
Lebedev
V S
VS
Kuzovnikova
T A
TA
Kornev
A P
AP
Fedorov
Iu I
IuI
D001692:Biological Transport / Q000187:drug effects; D003300:Copper / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D008564:Membrane Potentials / Q000187:drug effects; D013307:Streptomycin / Q000493:pharmacokinetics*
D003300:Copper; D013307:Streptomycin
Zakonomernosti indutsirovannogo med'iu transporta streptomitsina v Escherichia coli.