Synergistic effect of sialagogues in management of xerostomia after radiation therapy.
The combined effects of two sialagogues, with proposed different mechanisms of action, were studied in a phase I/II trial in the management of xerostomia. Improvement in saliva-flow rates and subjective symptoms were seen in the patients.
Epstein
J B
JB
Schubert
M M
MM
D000328:Adult; D000368:Aged; D000781:Anethole Trithione / Q000008:administration & dosage*; D000840:Anisoles / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010862:Pilocarpine / Q000008:administration & dosage*; D011878:Radiotherapy / Q000009:adverse effects*; D012463:Saliva / Q000187:drug effects / Q000378:metabolism; D012636:Secretory Rate; D014987:Xerostomia / Q000188:drug therapy* / Q000209:etiology
D000840:Anisoles; D010862:Pilocarpine; D000781:Anethole Trithione