A group of related surface glycoproteins distinguish sets and subsets of sensory afferents in the leech nervous system.
The distribution of 4 surface glycoproteins on axons of peripheral neurons was studied in the leech Hirudo medicinalis through monoclonal antibodies. All 4 glycoproteins have a similar molecular weight of 130 kDa. Immunohistochemical localization of these glycoproteins on tissue sections of nerves and neuropil reveals tracts of afferent axons organized as nested sets. Their distribution suggests a possible role for these molecules in mediating axon fasciculation.
Peinado
A
A
Macagno
E R
ER
Zipser
B
B
D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis; D001369:Axons / Q000032:analysis; D006023:Glycoproteins / Q000032:analysis*; D007158:Immunologic Techniques; D007865:Leeches / Q000032:analysis*; D008970:Molecular Weight; D009475:Neurons, Afferent / Q000032:analysis*; D010525:Peripheral Nerves / Q000032:analysis
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D006023:Glycoproteins