title: Comparison of hydrolases, peroxidase and protease inhibitors in bronchoalveolar fluid from Macacus cynomolgus and human controls.
abstract: 1. Serial bronchoalveolar lavages were performed on a subhuman primate (Macacus cynomolgus) in order to give an experimental model for silicosis. 2. We have measured glycosidases, proteases, peroxidase and antiproteases of the BAL fluids from seven normal monkeys. 3. The results obtained were similar to those found in human control BAL fluids. 4. For monkeys, the repetition of the bronchoalveolar procedure does not seem to have an important influence on the values obtained. 5. The present results will now permit sequential follow up studies during the course of experimental silicosis.
authors.affiliation: Unité des Protéines INSERM No. 16, Lille, France.
authors.forename: M H
authors.initials: MH
authors.lastname: Hannothiaux
authors.forename: A
authors.initials: A
authors.lastname: Scharfman
authors.forename: J J
authors.initials: JJ
authors.lastname: Lafitte
authors.forename: L
authors.initials: L
authors.lastname: Cornu
authors.forename: H
authors.initials: H
authors.lastname: Daniel
authors.forename: P
authors.initials: P
authors.lastname: Roussel
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis / Q000201:enzymology*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D006867:Hydrolases / Q000378:metabolism*; D007123:Immunoelectrophoresis, Two-Dimensional; D008252:Macaca fascicularis; D010447:Peptide Hydrolases / Q000378:metabolism*; D010544:Peroxidases / Q000378:metabolism*; D011480:Protease Inhibitors / Q000032:analysis*
chemical_list: D011480:Protease Inhibitors; D010544:Peroxidases; D006867:Hydrolases; D010447:Peptide Hydrolases