title: Bacterial viruses, prophages, and plasmids, reconsidered.
abstract: Prophages and plasmids offer to the bacterial cells generalized access to each other's genes. The result is an extremely rich, available gene bank. It has successfully supported the original bacterial life since its beginnings and therefore it has conditioned all bacterial cells. Thus, most of the basic mechanisms for the living world, the richest variety of new genes, and particularly the improved ways of using DNA as an extremely adaptable genetic material happened in bacteria with the help of prophages and plasmids. This fact has profoundly marked all the biosphere. The ancestor of the nucleus probably started as an accumulation of prophages and plasmids integrated in the growing "chromosome" of the outer symbiont of the first eukaryotes. Many bacterial vestiges were probably retained in eukaryotes, mostly those related to the dominant and lasting role of small replicons in all their bacterial precursors. These vestiges may, for example, serve as an endogenic source for some DNA viruses in eukaryotes. The other animal and plant viruses seem to derive directly or indirectly from prophages or plasmids. In the case of RNA viruses they may have originated from probable RNA small replicons present in the first forms of life on earth. Some confusion arose in biology, as viruses were discovered first and therefore their most probable ancestors, the plasmids and the prophages which were discovered later, were thought to be viruslike, or viruses, as is the case with prophages.
authors.forename: S
authors.initials: S
authors.lastname: Sonea
mesh_terms: D001419:Bacteria / Q000235:genetics; D001435:Bacteriophages / Q000235:genetics*; D005075:Biological Evolution; D004269:DNA, Bacterial; D004279:DNA, Viral; D005057:Eukaryotic Cells; D008242:Lysogeny; D010957:Plasmids; D012093:Replicon; D013559:Symbiosis; D014161:Transduction, Genetic; D014162:Transfection
chemical_list: D004269:DNA, Bacterial; D004279:DNA, Viral