[Endoscopic studies of the stomach tolerance of ibuprofen: comparison of 2 galenically different preparations].
In randomised crossover fashion, the gastric and duodenal tolerability of two different ibuprofen galenic formulations were directly compared in ten healthy volunteers. An endoscopic evaluation was performed after 7 and 14 days treatment. 300 mg Ibuprofen q.i.d. as pellets, as well as 600 mg Ibuprofen b.i.d. as dragees, evoked a lesion score of 1.6 +/- 0.3 and 1.7 +/- 0.4 after 7 days of treatment (n.s.). After 14 days, the lesion score under ibuprofen dragees was slightly higher (1.9 +/- 0.3) when compared with the pellet formulation (1.6 +/- 0.3). This difference did not reach statistical significance. Both ibuprofen preparations were well tolerated.
Müller
P
P
Medizinische Universitätsklinik Heidelberg, Gastroenterologische Abteilung.
Dammann
H G
HG
Simon
B
B
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004304:Dosage Forms; D004381:Duodenal Ulcer / Q000139:chemically induced*; D005753:Gastric Mucosa / Q000187:drug effects; D005773:Gastroscopy; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D007413:Intestinal Mucosa / Q000187:drug effects; D011897:Random Allocation; D012307:Risk Factors; D013276:Stomach Ulcer / Q000139:chemically induced*
D004304:Dosage Forms; D007052:Ibuprofen
Endoskopische Untersuchungen zur Magenverträglichkeit von Ibuprofen: Vergleich zweier galenisch unterschiedlicher Zubereitungen.