title: [Intravenous penicillin therapy in high doses in neurosyphilis: study of 62 cases. I. Clinical evaluation].
abstract: Sixty-two patients with symptomatic neurosyphilis were treated with 20 or 24 megaunits of intravenous penicillin G daily for 15 to 30 days. The mean follow-up time after the treatment was 30 months. Thirteen patients developed new neurological signs after the treatment. Their diagnosis were: general paresis (9), taboparesis (2), tabes dorsalis (1) and meningovascular neurosyphilis (1). After the treatment, thirty-six patients (58.1%) improved, 22 patients (35.5%) were unchanged and 4 patients (6.4%) deteriorated on clinical grounds. In two patients there was a progression to other forms of neurosyphilis. The results of the treatment of these patients with high doses of intravenous penicillin G were not different from the results verified with classical intramuscular penicillin that were reported in the literature, from the clinical standpoint.
authors.affiliation: Clínica Neurológica do Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo.
authors.forename: R
authors.initials: R
authors.lastname: Nitrini
authors.forename: A
authors.initials: A
authors.lastname: Spina-França
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009494:Neurosyphilis / Q000188:drug therapy*; D010400:Penicillin G / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D010400:Penicillin G
vernacular_title: Penicilinoterapia intravenosa em altas doses na neurossífilis: estudo de 62 casos. I. Avaliação clínica.