Initial depression and response to imipramine in agoraphobia.
Thirty-seven patients participating in a controlled treatment study with imipramine were classified as high or low depressed simultaneously on two depression measures. Analysis of variance by 2 (high-low depressed) X 2 (high-low imipramine dosage) groupings revealed significant dose but no depression main effects. The greater dose effect observed in the low depressed group and the greater response rates found among high-dose patients with low initial depression strongly suggest that the beneficial effect of imipramine in agoraphobia was not primarily antidepressant in nature.
Mavissakalian
M
M
D000379:Agoraphobia / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D002986:Clinical Trials as Topic; D003863:Depression / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D003866:Depressive Disorder / Q000150:complications / Q000175:diagnosis; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D010698:Phobic Disorders / Q000188:drug therapy*; D011569:Psychiatric Status Rating Scales
D007099:Imipramine