Circulating immunocomplexes in the diagnosis of autoimmune and neoplastic disorders: new perspectives.
Two new competitive immunoenzymatic assays ("C.I.C.-conglutinin" and "C.I.C.-C1q") were employed to evaluate circulating immunocomplexes in 90 patients with a variety of autoimmune and neoplastic disorders. In autoimmune diseases the assays appeared very sensitive and relatively concordant, while in malignancies sensitivity was high with the C.I.C.-conglutinin method but much lower with the C.I.C.-C1q method. The clinical significance of these results is discussed with particular regard to the possibilities of application of the two assays in the diagnostic routine of a general hospital laboratory.
Grassi
R
R
Immunohematology and Blood Transfusion Service, Hospital of the Local Health Unit, Lucca, Italy.
Grazzini
G
G
Sodini
F
F
Ronchi
M C
MC
Nottolini
M
M
D000936:Antigen-Antibody Complex / Q000032:analysis*; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology; D014408:Biomarkers, Tumor / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D009369:Neoplasms / Q000175:diagnosis* / Q000276:immunology
D000936:Antigen-Antibody Complex; D014408:Biomarkers, Tumor