Comparison of L-baclofen and racemic baclofen in trigeminal neuralgia.
L-Baclofen was compared with racemic baclofen (Lioresal) in a double-blind crossover trial in 15 patients with typical trigeminal neuralgia. L-Baclofen was more effective than five times as much racemic baclofen in nine patients. Six of these nine patients have continued pain-free on L-baclofen for 4 to 17 months (mean, 10 months). L-Baclofen was much better tolerated than racemic baclofen. Our results suggest that L-baclofen represents a significant improvement over racemic baclofen in the treatment of trigeminal neuralgia, and support our laboratory observations indicating that D-baclofen antagonizes the action of L-baclofen.
Fromm
G H
GH
Department of Neurology, University of Pittsburgh School of Medicine, PA 15261.
Terrence
C F
CF
D000328:Adult; D000368:Aged; D001418:Baclofen / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D007536:Isomerism; D008875:Middle Aged; D014277:Trigeminal Neuralgia / Q000188:drug therapy* / Q000503:physiopathology
D001418:Baclofen