title: Collateral ventilation of obstructed lung during high-frequency oscillation in dogs and pigs.
abstract: To determine if collateral ventilation (CV) occurs in pigs and dogs during intermittent positive-pressure ventilation (IPPV) and high-frequency oscillation (HFO), seven pigs and seven dogs were studied by measuring Xenon 133 washout (XeW) from an occluded subsegmental bronchus. The rate constant/min (K) for Xe blood uptake (KXeb) was derived, and when subtracted from K for XeW (KXeW) gave K for removal of Xe by CV (KXecv). Pig XeW were single exponentials with mean KXew = 0.25/min during IPPV and 0.12/min with HFO. In pigs, mean K of XeW was no different from KXeb so that all XeW occurred by blood uptake and none by CV. XeW in dogs had two exponentials. Dogs had over 11 times greater mean KXeW than pigs during IPPV and over 24 times greater during HFO. In dogs, on average, 79% (IPPV) and 87% (HFO) of XeW occurred by CV. CV is a means of gas exchange during HFO and IPPV in dogs but not in pigs.
authors.forename: J
authors.initials: J
authors.lastname: Takeda
authors.forename: C F
authors.initials: CF
authors.lastname: Mackenzie
authors.forename: R
authors.initials: R
authors.lastname: Watson
authors.forename: H G
authors.initials: HG
authors.lastname: Roberts
authors.forename: R
authors.initials: R
authors.lastname: Moorman
authors.forename: B H
authors.initials: BH
authors.lastname: Hoff
authors.forename: D
authors.initials: D
authors.lastname: Wilson
authors.forename: G S
authors.initials: GS
authors.lastname: Johnston
authors.forename: J L
authors.initials: JL
authors.lastname: Hill
mesh_terms: D000818:Animals; D001980:Bronchi / Q000378:metabolism; D004285:Dogs; D007385:Intermittent Positive-Pressure Ventilation; D011175:Positive-Pressure Respiration; D011659:Pulmonary Gas Exchange; D012121:Respiration, Artificial; D013045:Species Specificity; D013552:Swine; D014978:Xenon / Q000378:metabolism
chemical_list: D014978:Xenon