Activity of phenothiazines against medically important yeasts.
Two phenothiazine compounds, trifluoperazine and chlorpromazine, inhibited growth in vitro of the five most common pathogenic yeasts, with MICs ranging from 10 to 40 micrograms/ml. Daily intraperitoneal injections of trifluoperazine (4 to 7 mg/kg of body weight) increased the survival of mice experimentally infected with Candida albicans or Cryptococcus neoformans. The potential use of these drugs against fungal meningitis is discussed.
Eilam
Y
Y
Polacheck
I
I
Ben-Gigi
G
G
Chernichovsky
D
D
D000818:Animals; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002177:Candidiasis / Q000188:drug therapy; D002746:Chlorpromazine / Q000494:pharmacology*; D003453:Cryptococcosis / Q000188:drug therapy; D003454:Cryptococcus / Q000187:drug effects*; D003455:Cryptococcus neoformans / Q000187:drug effects* / Q000254:growth & development; D005260:Female; D006801:Humans; D051379:Mice; D014268:Trifluoperazine / Q000494:pharmacology*
D014268:Trifluoperazine; D002746:Chlorpromazine