title: History of chronic alcohol abuse is associated with increased nighttime hypoxemia in older men.
abstract: The all-night blood oxygen saturations (SaO2) of 19 older abstaining male alcoholics and 19 healthy age-matched controls were recorded. The alcohol group had significantly lower nighttime mean and minimum oxygen saturations, significantly greater absolute (mean-minimum) SaO2 desaturations, and significantly more desaturations below 90% compared with the control group. Additionally, the alcohol group had significantly more individuals with nighttime SaO2 means below 95% and nighttime SaO2 minimums below 90%. Finally, within the alcohol group, alcohol history was found to significantly correlate with nighttime mean and minimum SaO2 and absolute SaO2 desaturation. This preliminary study finds evidence that chronic alcohol abuse may predispose an individual to nighttime hypoxemia, and, inferentially, to sleep apnea. However, the effect is modest and it will need to be confirmed in larger, more carefully controlled studies.
authors.forename: M V
authors.initials: MV
authors.lastname: Vitiello
authors.forename: P N
authors.initials: PN
authors.lastname: Prinz
authors.forename: J P
authors.initials: JP
authors.lastname: Personius
authors.forename: M A
authors.initials: MA
authors.lastname: Nuccio
authors.forename: R K
authors.initials: RK
authors.lastname: Ries
authors.forename: R M
authors.initials: RM
authors.lastname: Koerker
mesh_terms: D000367:Age Factors; D000437:Alcoholism / Q000097:blood* / Q000150:complications; D002940:Circadian Rhythm; D006801:Humans; D000860:Hypoxia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012891:Sleep Apnea Syndromes / Q000209:etiology