[Cardiac effects of insulin in ethanol intoxication and in the postintoxication period].
Insulin (2 IU/ml) effect on the contractile function, glucose consumption and lactate release by the myocardium was studied in experiments on the isolated rat heart performed at different time after a single (8 g/kg) and 10-fold with a 12-hour interval (8-10 g/kg) intragastric administration of ethanol. A single administration of ethanol failed to influence the contractile function, glucose consumption and lactate release by the isolated heart. The magnitude of a positive inotropic reaction to insulin increased and its stimulating effect on glucose utilization by the myocardium weakened. The reaction of ethanol withdrawal developing after its 10-fold administration led to a disturbance of the contractile and rhythmic functions of the heart and activation of glycolysis. The heart inotropic reaction to insulin in this period weakened and glucose consumption and lactate release stimulated by insulin did not differ from control. During perfusion of intact rat hearts with and without glucose insulin (2 IU/ml) weakened the cardiodepressive effect of ethanol (200 mM).
Tezikov
E B
EB
Nuzhnyĭ
V P
VP
Savitskaia
E V
EV
D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013599:Systole / Q000187:drug effects; D013997:Time Factors
D007328:Insulin; D000431:Ethanol; D005947:Glucose
Kardial'nye éffekty insulina pri intoksikatsii étanolom i v postintoksikatsionnyĭ period.