title: Prostaglandin E1: an effective treatment of right heart failure after orthotopic heart transplantation.
abstract: Three patients are presented who had life-threatening postoperative pulmonary hypertension after orthotopic heart transplantation. This pulmonary hypertension was unresponsive to standard therapy but responded dramatically to treatment with prostaglandin E1. The problem of evaluating and treating heart transplant patients with pulmonary hypertension and the role of prostaglandins are discussed.
authors.affiliation: Division of Cardiothoracic Surgery, University of Pittsburgh, PA 15261.
authors.forename: J M
authors.initials: JM
authors.lastname: Armitage
authors.forename: R L
authors.initials: RL
authors.lastname: Hardesty
authors.forename: B P
authors.initials: BP
authors.lastname: Griffith
mesh_terms: D000527:Alprostadil / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology; D016027:Heart Transplantation; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy
chemical_list: D000527:Alprostadil