Lack of mutagenic activity of ademetionine in vitro and in vivo.
Studies on the mutagenic activity of ademetionine (S-adenosylmethionine) tested in vitro at concentrations of 2 mg/sample and in vivo at doses up to 1500 mg/kg always gave negative responses. Moreover, a patent lack of abnormal methylated bases in the liver DNA of ademetionine-treated rats suggests that, if abnormal methylation occurs by exogenously administered ademetionine, the amount of formed methylated residues must be quite lower than that removable by the transmethylase enzymes responsible for the in vivo repair.
Pezzoli
C
C
BioResearch Co., Research Laboratories, Liscate/Milan, Italy.
Galli-Kienle
M
M
Stramentinoli
G
G
D000818:Animals; D002869:Chromosome Aberrations; D006224:Cricetinae; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D005260:Female; D008099:Liver / Q000378:metabolism; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D011919:Rats, Inbred Strains; D012436:S-Adenosylmethionine / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects
D009153:Mutagens; D012436:S-Adenosylmethionine