Assay of the cell-mediated immunity in patients with malignant and non-malignant diseases.
The depression of cell-mediated immunity (CMI) was determined in patients with ovarian and breast carcinomas by lymphokine production under Con-A-stimulation (migration inhibitory factor), T-lymphocyte-transformation test under PHA-stimulation and with a skin reactivity test with a viscum album extract (Plenosol, Dr. Madaus, Cologne, FRG). The results show a good correlation between the different types of CMI function tests. The cytostatics have a depressive effect on CMI more through a cumulative effect than through the actual concentration. Some of the patients with chronic rheumatism who were not treated were anergic, and that also had an influence on the therapy.
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D001168:Arthritis / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology*; D002478:Cells, Cultured; D005260:Female; D006261:Headache / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D010051:Ovarian Neoplasms / Q000276:immunology*; D010146:Pain / Q000276:immunology; D012016:Reference Values; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology*