Some N-acyl-D-amino acid derivatives having antibotulinal properties.
Several N-acyl derivatives of D-tryptophan, D-alanine, D-methionine, D-valine, and D-aspartic acid were synthesized in high yields using the succinimidyl ester method and examined for their antibotulinal properties. In conjunction with 60 ppm of sodium nitrite, sorbyl-D-tryptophan, sorbyl-D-alanine, myristoyl-D-aspartic acid, and glycyl-D-alanine were highly inhibitory. In the absence of sodium nitrite, the N-acyl derivatives of the D-amino acids were not inhibitory. On its own, 60 ppm of sodium nitrite was only slightly inhibitory. Sorbyl-L-tryptophan and sorbyl-L-alanine had no effect in the presence or absence of 60 ppm of sodium nitrite.
Paquet
A
A
Food Research Centre, Canada Department of Agriculture, Ottawa, Ont.
Rayman
K
K
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003014:Clostridium botulinum / Q000187:drug effects*; D004952:Esters; D005516:Food Microbiology; D008460:Meat; D012977:Sodium Nitrite / Q000494:pharmacology; D013171:Spores, Bacterial / Q000187:drug effects; D013552:Swine
D000596:Amino Acids; D004952:Esters; D012977:Sodium Nitrite