The Wellcome Trust lecture. Inflammatory responses to filarial connective tissue parasites.
The inflammatory responses to lymphatic filariae and to Onchocerca volvulus are reviewed with particular attention to evolutionary biology; inflammatory host spectrum; non-specific components; immunoregulation; immune evasion versus immunomodulation; chronic tissue damage and scarring and disease models. Basic principles of pathogenesis are emphasized, comparisons drawn with schistosome infection, and critical items of missing information are highlighted.
von Lichtenberg
F
F
D000818:Animals; D002009:Brugia / Q000276:immunology / Q000502:physiology*; D003238:Connective Tissue / Q000469:parasitology* / Q000473:pathology; D005368:Filariasis / Q000276:immunology / Q000473:pathology*; D006790:Host-Parasite Interactions; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000276:immunology / Q000473:pathology; D009854:Onchocerca / Q000276:immunology / Q000502:physiology*; D014957:Wuchereria / Q000502:physiology*; D014958:Wuchereria bancrofti / Q000276:immunology / Q000502:physiology*