Diet and nutritional factors in the aetiology of colon cancer (review).
Epidemiological studies suggest that diet may be a major risk factor in the aetiology of colon cancer. Total fat, meat, animal protein and dietary fibre have received most attention. A high-fat - high-protein diet leading to increased faecal steroids has been implicated, but no active carcinogen derived from these has been isolated from human faeces. Alternatively, a refined, low fibre diet with decreased faecal bulk leads to increased large bowel concentration of carcinogens of co-carcinogens which contribute to the development of a malignant tumour. The aetiology of colonic cancer is probably multifactorial but a diet low in animal fat and protein and abundant in vegetables containing vitamin A and lignans may protect against colon cancer.
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D003110:Colonic Neoplasms / Q000453:epidemiology / Q000209:etiology*; D004032:Diet / Q000009:adverse effects*; D004813:Epidemiology; D005260:Female; D014943:Global Health; D006801:Humans; D008297:Male; D008954:Models, Biological; D009751:Nutritional Requirements; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D012306:Risk