title: Amino acid sequence of the beta subunit of bovine lung casein kinase II.
abstract: The amino acid sequence of the 209-residue beta subunit of bovine lung casein kinase II has been determined. Excluding the amino-terminal blocking group, which was not identified, the molecular weight of the polypeptide chain is 24,239. A marked polarity of the beta subunit is indicated by clusters of negative charges in the amino-terminal region and of positive charges in the carboxyl-terminal region. Whereas the beta subunit shows no homology with any known protein, a segment of the sequence of the larger and microheterogeneous alpha subunit exhibits homology with the catalytic domains of other protein kinases, particularly with the yeast cell-division-control protein CDC28.
authors.forename: K
authors.initials: K
authors.lastname: Takio
authors.forename: E A
authors.initials: EA
authors.lastname: Kuenzel
authors.forename: K A
authors.initials: KA
authors.lastname: Walsh
authors.forename: E G
authors.initials: EG
authors.lastname: Krebs
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D047388:Casein Kinases; D002417:Cattle / Q000235:genetics*; D008168:Lung / Q000201:enzymology; D011494:Protein Kinases / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
chemical_list: D011494:Protein Kinases; D047388:Casein Kinases