Mutagenic activity of 27 dyes and related chemicals in the salmonella/microsome and mouse lymphoma TK+/- assays.
A total of 27 dyes and related chemicals were tested for mutagenicity in both the Salmonella typhimurium plate-incorporation and FMN-modified assays as well as the mouse lymphoma TK+/- assay. Half of the compounds tested were monoazo dyes (14); the remainder consisted of disazo (3), aminotriphenylmethane derivatives (4), and other miscellaneous (6) color compounds. The results obtained in this study are compared with data from dyes of the same batch tested in other laboratories in the Salmonella plate-incorporation assay and in both in vitro and in vivo/in vitro UDS assays. Agreement of results from the various assays that could be compared (excluding results that were equivocal or indeterminate) ranged from 80 to 91%. Sufficient data were available to provide an overall index of in vitro activity for 15 chemicals; of these, 14 compounds could be compared to and agreed with reports of their carcinogenic potential in the literature.
Cameron
T P
TP
National Cancer Institute, Bethesda, MD 20892.
Hughes
T J
TJ
Kirby
P E
PE
Fung
V A
VA
Dunkel
V C
VC
D000818:Animals; D004396:Coloring Agents / Q000494:pharmacology*; D006224:Cricetinae; D007940:Leukemia L5178 / Q000201:enzymology / Q000235:genetics; D008297:Male; D008647:Mesocricetus; D051379:Mice; D009152:Mutagenicity Tests; D009363:Neoplasm Proteins / Q000235:genetics; D051381:Rats; D011916:Rats, Inbred F344; D012486:Salmonella typhimurium / Q000187:drug effects*; D013937:Thymidine Kinase / Q000235:genetics; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000201:enzymology
D004396:Coloring Agents; D009363:Neoplasm Proteins; D013937:Thymidine Kinase