title: 2,3-Bisphosphoglycerate inhibits ATP-stimulated proteolysis.
abstract: Intracellular protein breakdown could be regulated at the substrate level by changes in the environment. Under in vitro conditions, ATP increases the proteolytic susceptibility of several mitochondrial and cytosolic proteins, while 2,3-bisphosphoglycerate not only has the opposite effect but also prevents the ATP-stimulated proteolysis. ATP and 2,3-bisphosphoglycerate, present at relatively high levels in many tissues, provide a good model of environmental components that may influence intracellular proteolysis.
authors.forename: E
authors.initials: E
authors.lastname: Roche
authors.forename: F
authors.initials: F
authors.lastname: Aniento
authors.forename: E
authors.initials: E
authors.lastname: Knecht
authors.forename: S
authors.initials: S
authors.lastname: Grisolía
mesh_terms: D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D004163:Diphosphoglyceric Acids / Q000494:pharmacology*; D019286:Endopeptidase K; D010450:Endopeptidases / Q000494:pharmacology; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D010196:Pancreatic Elastase / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004163:Diphosphoglyceric Acids; D011506:Proteins; D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D010450:Endopeptidases; D010196:Pancreatic Elastase; D019286:Endopeptidase K