title: The effect of captopril on blood pressure and glucose tolerance in hypertensive non-insulin dependent diabetics.
abstract: Thirteen hypetensive non-insulin dependent diabetics (9 male, 4 female, mean age 61.6 +/- 6 years) were given 6 weeks treatment with captopril in a dose range 75-150 mg/day. Each patient underwent a standard glucose tolerance test and had blood pressure profiles recorded before and after captopril. Supine systolic blood pressure (mmHg) improved from 181 (+/- 16) to 162 (+/- 17) and diastolic blood pressure from 103 (+/- 11) to 89 (+/- 9). A similar improvement was seen in erect systolic (174 +/- 19 to 156 +/- 19) and diastolic (103 +/- 14 to 87 +/- 11) blood pressures. Following treatment there was no significant change in glucose tolerance although the 120 minute plasma glucose value improved from 15.3 +/- 4.2 to 13.9 +/- 3.4 mmol/l (P less than 0.05). The drug was well tolerated and free of adverse effects. Captopril would therefore appear to be an effective and safe anti-hypertensive agent in non-insulin dependent diabetes and did not result in any deterioration of glucose tolerance.
authors.affiliation: Diabetic Department, The Royal Infirmary, Edinburgh, EH39YW, UK.
authors.forename: D W
authors.initials: DW
authors.lastname: Matthews
authors.forename: C G
authors.initials: CG
authors.lastname: Wathen
authors.forename: D
authors.initials: D
authors.lastname: Bell
authors.forename: A
authors.initials: A
authors.lastname: Collier
authors.forename: A L
authors.initials: AL
authors.lastname: Muir
authors.forename: B F
authors.initials: BF
authors.lastname: Clarke
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D002216:Captopril