Radioprotection of peripheral blood cells with a combination of hydroxytryptophan and a thiol compound in mice.
Radiation induced changes in peripheral blood cells were studied in male Swiss albino mice after 4 Gy and 10 Gy whole body gamma irradiation with and without pretreatment with 2-amino-ethylisothiuronium bromide hydrobromide (AET) or with a combination of 5-hydroxy-L-tryptophan (5-HTP) and AET. Combination of 5-HTP with AET or AET alone in a high dose achieved excellent protection against both 4 Gy and 10 Gy whole body irradiation as regards peripheral blood cell counts.
Basu
S K
SK
Radiation Biochemistry Division, Institute of Nuclear Medicine and Allied Sciences, Delhi, India.
Chandra
K
K
Chuttani
K
K
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D001773:Blood Cells / Q000187:drug effects / Q000528:radiation effects*; D004906:Erythrocyte Count; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D011829:Radiation Dosage; D011837:Radiation-Protective Agents; D013997:Time Factors; D014916:Whole-Body Irradiation; D000338:beta-Aminoethyl Isothiourea / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D006916:5-Hydroxytryptophan