title: Computerized EEG correlates of depression and antidepressant treatment.
abstract: Quantitative EEG was used to examine: differences between non-medicated depressives and normal controls; chronic effects of antidepressant drug treatment. Spectral analysis of cortical EEG activity revealed: significant group differences in slow and fast wave activity and significant differences in hemispheric asymmetry; limited effects of antidepressants which were restricted to slow wave activity. Group differences are supportive of cortical disactivation of the right-hemisphere in depressive disorders and the limited drug-EEG effects in depressives argue for additional studies on multi-lead oriented pharmaco-EEG profiles in psychiatric populations.
authors.forename: V J
authors.initials: VJ
authors.lastname: Knott
authors.forename: Y D
authors.initials: YD
authors.lastname: Lapierre
mesh_terms: D015057:1-Naphthylamine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003201:Computers; D003866:Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000295:instrumentation*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D009281:Naphthalenes / Q000627:therapeutic use*; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D020280:Sertraline
chemical_list: D009281:Naphthalenes; D012702:Serotonin Antagonists; D000639:Amitriptyline; D015057:1-Naphthylamine; D020280:Sertraline