title: Effects of dipyridamole on prostaglandin synthesis in human fibroblasts.
abstract: The effect of varied doses of dipyridamole (Persantin) on the arachidonic acid metabolites prostaglandin (PG)I2, PGE2 and thromboxane (TX)A2 has been studied in human skin fibroblasts cultured in vitro. A 24-h exposure to the drug induced a dose-dependent increase of all the examined prostaglandins (PG's). Bradykinin stimulation of cells that had been preexposed to the drug induced a continuous increase in PG-production as compared to controls, despite the absence of the drug. In addition, an acute 5-min exposure to dipyridamole produced an increased thromboxane production, but no consistent changes of PGI2 or PGE2, and it inhibited significantly and dose-dependently the comcomitant bradykinin stimulated production of all the examined PG's. The implications of a combined dipyridamole-acetylsalicylic acid therapy is discussed.
authors.forename: O
authors.initials: O
authors.lastname: Oetliker
authors.forename: C
authors.initials: C
authors.lastname: Lüthy
authors.forename: M
authors.initials: M
authors.lastname: Siegrist
authors.forename: R
authors.initials: R
authors.lastname: Odavic
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D001920:Bradykinin / Q000494:pharmacology; D002478:Cells, Cultured; D002675:Child, Preschool; D004176:Dipyridamole / Q000494:pharmacology*; D011464:Epoprostenol / Q000096:biosynthesis; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis*; D013268:Stimulation, Chemical; D013931:Thromboxanes / Q000096:biosynthesis
chemical_list: D011453:Prostaglandins; D013931:Thromboxanes; D015121:6-Ketoprostaglandin F1 alpha; D004176:Dipyridamole; D011464:Epoprostenol; D001920:Bradykinin