Interaction between Candida agglutinins and antifungal agents.
Antifungal agents alter the function and morphology of Candida cell membranes and cell walls. We observed that brief (30 minute) exposure to either amphotericin B or clotrimazole inhibited the agglutination of Candida blastoconidia by murine bronchoalveolar lavage fluid. This inhibition required continuous drug presence. Neither amphotericin nor clotrimazole inhibited Candida agglutination by concanavalin A or pooled human serum. These results demonstrate that antifungal drugs can produce rapid changes in the surface characteristics of some fungi.
Lutz
J C
JC
Nugent
K M
KM
D000371:Agglutination / Q000187:drug effects; D000373:Agglutinins / Q000378:metabolism*; D000666:Amphotericin B / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D002176:Candida albicans / Q000187:drug effects* / Q000276:immunology / Q000648:ultrastructure; D002462:Cell Membrane / Q000187:drug effects; D002473:Cell Wall / Q000187:drug effects; D003022:Clotrimazole / Q000378:metabolism / Q000494:pharmacology*; D003208:Concanavalin A / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology*; D051379:Mice
D000373:Agglutinins; D007093:Imidazoles; D003208:Concanavalin A; D000666:Amphotericin B; D003022:Clotrimazole