N-methyl-N'-nitro-N-nitrosoguanidine-induced resistance to ionizing radiation.
N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) pretreatments increase the resistance of Escherichia coli to gamma-radiation. The increased resistance is dependent on functional polA, recA, recB, recC, and lexA genes and is partly dependent on recN. The MNNG-induced resistance is additive to resistance induced by pretreatment with gamma-radiation but not by increases induced by hydrogen peroxide. The MNNG-induced resistance occurs in adaptive response mutants and at pretreatment levels of MNNG that do not activate cells to reactivate UV-inactivated lambda phage. The MNNG-induced resistance appears to be distinct from other inductions to gamma-radiation resistance.
Morse
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Smith
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D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development / Q000528:radiation effects*; D005720:Gamma Rays; D005838:Genotype; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D011837:Radiation-Protective Agents; D012293:Rifampin / Q000494:pharmacology; D013045:Species Specificity
D011837:Radiation-Protective Agents; D008769:Methylnitronitrosoguanidine; D012293:Rifampin