Suckling increases insulin and glucagon levels in peripheral venous blood of lactating dogs.
The aim of the present investigation was to study changes in insulin, glucagon and plasma glucose levels in response to suckling in lactating dogs. Blood samples were drawn from a peripheral vein during suckling in weeks 1 and 3 of lactation in 10 lactating beagles. Insulin- and glucagon-like immunoreactivity (below referred to as insulin and glucagon) were determined by radio-immunoassay, and plasma glucose levels by the glucose oxidase method. Insulin and glucagon levels rose following onset of suckling. However, only the rises recorded in week 3 of lactation were statistically significant. Plasma glucose levels were not affected. The mechanism by which suckling influences the levels of insulin and glucagon is not known. However, the release of both hormones is under vagal control and it is possible that touching of the teats reflexly elicits a vagally mediated release of these hormones. Alternatively, since oxytocin stimulates the secretion of insulin and glucagon, the effects might be secondary to the oxytocin released by suckling. The physiological function of the suckling-related release of insulin may be to stimulate milk production. Furthermore, since glucagon is also released, each suckling period may be accompanied by a transfer of glucose to the mammary glands from other maternal stores.
Eriksson
M
M
Department of Pharmacology, Karolinska Institute, Stockholm, Sweden.
Lindén
A
A
Uvnäs-Moberg
K
K
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs; D005260:Female; D005934:Glucagon / Q000097:blood*; D004763:Glucagon-Like Peptides; D007328:Insulin / Q000097:blood*; D007774:Lactation / Q000097:blood*; D010455:Peptides / Q000097:blood; D011247:Pregnancy; D013391:Sucking Behavior / Q000502:physiology*
D001786:Blood Glucose; D007328:Insulin; D010455:Peptides; D004763:Glucagon-Like Peptides; C015236:glucagon-like-immunoreactivity; D005934:Glucagon