title: Significance of hemorrhage into brain tumors: clinicopathological study.
abstract: A retrospective clinical and pathological review of 905 consecutive brain tumor cases (excluding pituitary adenoma and recurrent tumor) was conducted to identify cases in which intratumoral hemorrhage was confirmed grossly and/or pathologically. There were 132 cases so identified, for an overall tumor hemorrhage rate of 14.6%; of these, 5.4% were classified as macroscopic and 9.2% as microscopic. The presence of hemorrhage was correlated with the neurological presentation. The highest hemorrhage rate (70.0%) was found in patients with prior neurological history who experienced apoplectic deterioration (acute-on-chronic presentation). Only 57.1% of patients with acute deterioration in the absence of prior neurological symptoms had hemorrhages. The highest hemorrhage rate for primary brain tumors was 29.2% for mixed oligodendroglioma/astrocytoma, while the highest hemorrhage rate for any tumor type was 50% for metastatic melanoma. The clinical relevance of tumor hemorrhage is discussed.
authors.affiliation: Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Ontario, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Kondziolka
authors.forename: M
authors.initials: M
authors.lastname: Bernstein
authors.forename: L
authors.initials: L
authors.lastname: Resch
authors.forename: C H
authors.initials: CH
authors.lastname: Tator
authors.forename: J F
authors.initials: JF
authors.lastname: Fleming
authors.forename: R G
authors.initials: RG
authors.lastname: Vanderlinden
authors.forename: H
authors.initials: H
authors.lastname: Schutz
mesh_terms: D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies