The effect of DOCA and 9 alpha-fludrocortisone on renal renin content and production.
1. DOCA and 9 alpha-fludrocortisone were given to rats. 2. Plasma renin fell rapidly with both treatments. 3. Renal renin fell slowly to a low level. 4. Renal renin fell to a lower level with DOCA than with 9 alpha-fludrocortisone. 5. When DOCA and 9 alpha-fludrocortisone were stopped plasma renin levels rose rapidly and the renal renin levels increased. 6. The data suggest that synthesis is altered rapidly but it takes a prolonged time for the kidney to become depleted of renin due to the high tissue stores and the associated inhibition of release.
Menting
J
J
Department of Physiology, University of Melbourne, Parkville, Australia.
Morgan
T
T
Barrett
G
G
Di Nicolantonio
R
R
D015065:17-Hydroxycorticosteroids / Q000494:pharmacology*; D000818:Animals; D003350:Cortodoxone / Q000494:pharmacology*; D004032:Diet; D005438:Fludrocortisone / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000378:metabolism*; D012965:Sodium Chloride / Q000008:administration & dosage
D015065:17-Hydroxycorticosteroids; D012965:Sodium Chloride; D012083:Renin; D005438:Fludrocortisone; D003350:Cortodoxone