[Course of the diffusion of cefotiam in infected ascitic fluid].
The cefotiam (CFT) penetration in infected ascitic fluid was investigated in 12 cirrhotic patients. CFT (1 g every 8 h) was given intravenously and measured by HPLC in plasmatic and ascitic samples. The mean ascitic concentrations (+/- SEM), 1 h, 3 h and 8 h after the first injection (J1) were 14.6 +/- 4.6, 11.8 +/- 3 and 8.4 +/- 2.9 micrograms/ml respectively. These values were 38, 62 and 88% of the corresponding mean plasmatic concentrations and higher than the MIC's for the organisms most commonly involved. The mean plasmatic and ascitic concentrations, a few days later (4.5 or 6 days) (Jn) were not significantly different from the corresponding values at J1. A significant decrease of polymorphonuclear cell count was observed between J1 and Jn. These results suggest that CFT diffusion into ascitic fluid is independent of inflammation and CFT is an adequate antibiotic in cirrhotic patients with infected ascitic fluid.
Latrive
J P
JP
Service de Gastroentérologie, Centre Hospitalier de Compiègne.
Barbare
J C
JC
Darchis
J P
JP
Hercelin
B
B
Rosembaum
M
M
D000328:Adult; D000368:Aged; D001202:Ascitic Fluid / Q000378:metabolism* / Q000382:microbiology; D001424:Bacterial Infections / Q000188:drug therapy* / Q000378:metabolism; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D015310:Cefotiam; D004058:Diffusion; D004926:Escherichia coli / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013296:Streptococcus pneumoniae / Q000302:isolation & purification; D015009:Yersinia Infections / Q000188:drug therapy; D015008:Yersinia enterocolitica / Q000302:isolation & purification
D015310:Cefotiam; D002439:Cefotaxime
Evolution de la diffusion du céfotiam dans le liquide d'ascite infecté.