Short-term studies on the use of amino acids as an osmotic agent in continuous ambulatory peritoneal dialysis.
1. A 1% amino acid dialysis solution with a high concentration of the branched-chain amino acids has been compared with 1.36% glucose in short-term studies. 2. The 1% amino acid solution was as effective an agent as 1.36% glucose with respect to ultrafiltration and clearance of creatinine, urea and potassium. 3. Levels of branched-chain amino acids rose to the upper end of the normal range within 1 h and remained at this level over the entire period of the study. Total and non-essential amino acids had returned to baseline by the end of the cycle. 4. Blood glucose rose to significantly greater levels during the 1.36% glucose exchange than during the 1% amino acid exchange. There was an increase in serum insulin levels during both cycles; this was significantly greater with the 1% amino acid solution than the 1.36% glucose. 5. There was no evidence of short-term metabolic complications with the 1% amino acid solution.
Goodship
T H
TH
Department of Medicine, University of Newcastle upon Tyne, U.K.
Lloyd
S
S
McKenzie
P W
PW
Earnshaw
M
M
Smeaton
I
I
Bartlett
K
K
Ward
M K
MK
Wilkinson
R
R
D000328:Adult; D000596:Amino Acids / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005934:Glucagon / Q000097:blood; D005947:Glucose; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods*; D012996:Solutions
D000596:Amino Acids; D001786:Blood Glucose; D007328:Insulin; D012996:Solutions; D005934:Glucagon; D005947:Glucose