The uridine nucleotides constitute a natriuretic pressor system.
1. Uridine monophosphate was tested in the conscious rat for natriuretic properties and an immunoperoxidase technique was used to localize uridine-containing compounds in the rat kidney. 2. Uridine monophosphate, infused in a moderate pressor dose, caused a significant natriuresis compared to the effect of control infusions of solvent vehicle. 3. Uridine-containing compounds were found in most tubular elements with particularly dense staining in the distal and collecting tubules. 4. While the increased sodium excretion may have been due to increased renal perfusion pressure, the high density of uridine staining in distal nephrons suggests that the uridine nucleotides have a specific nephron function, possibly relating to sodium transport.
Macdonald
G
G
University of New South Wales, School of Medicine, Little Bay, Australia.
Assef
R
R
Watkins
S
S
Burrell
J
J
D000818:Animals; D007124:Immunoenzyme Techniques; D007262:Infusions, Intravenous; D007668:Kidney / Q000378:metabolism; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014500:Uracil Nucleotides / Q000494:pharmacology*; D014542:Uridine Monophosphate / Q000494:pharmacology*
D014500:Uracil Nucleotides; D014542:Uridine Monophosphate