title: The new generation gelatins. A review of their history, manufacture and properties.
abstract: Gelatin solutions of various kinds have been used as intravenous infusions since the First World War and belong to a heterogeneous group of fluids which tend to maintain the colloid osmotic pressure. They are produced by the breakdown of bovine collagen to yield solutions with a range of molecular weights. Anaphylactoid reactions are a rare but well-recognised complication of their use. The solutions help to fill a hiatus that exists between crystalloids and blood products.
authors.affiliation: Shackleton Department of Anaesthetics, Southampton General Hospital.
authors.forename: J M
authors.initials: JM
authors.lastname: Saddler
authors.forename: P J
authors.initials: PJ
authors.lastname: Horsey
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced; D003102:Colloids; D005780:Gelatin / Q000009:adverse effects / Q000266:history; D049673:History, 20th Century; D006801:Humans; D007262:Infusions, Intravenous; D010952:Plasma Substitutes / Q000009:adverse effects / Q000266:history
chemical_list: D003102:Colloids; D010952:Plasma Substitutes; D005780:Gelatin