[A new peptide activator of reparative tissue regeneration].
Synthetic analog of leucine enkephalin--hexapeptide dalargin was shown to stimulate healing of skin wounds in rats, dogs and mini-pigs at local and parenteral administration in doses of 0.1-100 micrograms/kg. Acceleration of proliferation with an increase of fibroblast mitoses, earlier and active growth of vascular elements, rapid maturation of granulation tissue and accelerated epithelialization were observed.
Il'inskiĭ
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Solov'eva
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D000818:Animals; D004285:Dogs; D004743:Enkephalin, Leucine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D005260:Female; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D008297:Male; D009824:Ointments; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects / Q000293:injuries; D013268:Stimulation, Chemical; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D009824:Ointments; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Novyĭ peptidnyĭ aktivator reparativnoĭ regeneratsii tkaneĭ.