title: Ventilation imaging in the horse with 99mtechnetium-DTPA radioaerosol.
abstract: This study describes the development of a radioaerosol technique for horses using 99mtechnetium-DTPA (diethylenetriaminepentacetate). In 24 normal, adult horses, very satisfactory ventilation images were obtained with the technique. Four-minute administrations of the aerosol resulted in a mean uptake of radioactivity in the lung fields of 3.02 mCi, with mean maximum counts (+/- sd) of 159,800 +/- 75,000 per camera field. The mean clearance half-time for the 99mtechnetium-DTPA from the lung fields was 55.6 +/- 14.2 mins which is very similar to figures obtained for normal human and dog lungs. The results of this study suggest that ventilation imaging with 99mtechnetium-DTPA is a clinically practical method of obtaining regional information on ventilation function in the horse.
authors.affiliation: Department of Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: M W
authors.initials: MW
authors.lastname: O'Callaghan
authors.forename: W J
authors.initials: WJ
authors.lastname: Hornof
authors.forename: P E
authors.initials: PE
authors.lastname: Fisher
authors.forename: O G
authors.initials: OG
authors.lastname: Rabbe
mesh_terms: D000336:Aerosols; D000818:Animals; D006736:Horses / Q000502:physiology*; D008168:Lung / Q000000981:diagnostic imaging; D009296:Nasal Cavity / Q000000981:diagnostic imaging; D009330:Nebulizers and Vaporizers / Q000662:veterinary; D009942:Organometallic Compounds / Q000008:administration & dosage; D004369:Pentetic Acid / Q000008:administration & dosage; D011877:Radionuclide Imaging; D012119:Respiration; D012137:Respiratory System / Q000000981:diagnostic imaging*; D016284:Technetium Tc 99m Pentetate
chemical_list: D000336:Aerosols; D009942:Organometallic Compounds; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate