title: Immunoscintigraphy in the follow-up of patients operated on for carcinoma of the sigmoid and rectum. Preliminary report with a new monoclonal antibody: B72.3.
abstract: Thirty patients who had curative surgery for sigmoid and rectal carcinoma were studied by immunoscintigraphy using a new monoclonal antibody: B72.3 radiolabeled with Iodine-131 (I-131) or Indium-111 (In-111). Results were compared with other conventional diagnostic procedures such as computed tomography, ultrasound, endoscopy, and tumor markers. Seven patients had local recurrences and/or distant metastases. Immunoscintigraphy identified all local recurrences (five cases) that were confirmed by CT and was able to localize three of five liver metastases (two false-negatives). Furthermore, immunoscintigraphy also recorded a false-positive. Preliminary use of B72.3 shows good potential for the evaluation and detection of neoplastic sites.
authors.forename: A
authors.initials: A
authors.lastname: Renda
authors.forename: M
authors.initials: M
authors.lastname: Salvatore
authors.forename: M
authors.initials: M
authors.lastname: Sava
authors.forename: R
authors.initials: R
authors.lastname: Landi
authors.forename: S
authors.initials: S
authors.lastname: Lastoria
authors.forename: L
authors.initials: L
authors.lastname: Coppola
authors.forename: J
authors.initials: J
authors.lastname: Schlom
authors.forename: D
authors.initials: D
authors.lastname: Colcher
authors.forename: G
authors.initials: G
authors.lastname: Zannini
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D004724:Endoscopy; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D011877:Radionuclide Imaging; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000601:surgery; D012811:Sigmoid Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D000911:Antibodies, Monoclonal