Effect of nifedipine on serum theophylline concentrations and asthma control.
The effect of adding slow release nifedipine to oral theophylline has been studied in eight patients with stable but symptomatic asthma, a double blind placebo controlled crossover protocol being used. No change in asthma control occurred during the nifedipine treatment period as assessed by serial peak flow measurements and symptom scores. Serum theophylline concentrations were significantly lower after nifedipine than after placebo (6.8 v 9.7 micrograms/ml) and in three patients were well below the therapeutic range (less than 4 micrograms/ml).
Smith
S R
SR
Department of Clinical Pharmacology and Therapeutics, Medical School, University of Birmingham.
Wiggins
J
J
Stableforth
D E
DE
Skinner
C
C
Kendall
M J
MJ
D000368:Aged; D001249:Asthma / Q000097:blood* / Q000188:drug therapy; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D013806:Theophylline / Q000097:blood* / Q000627:therapeutic use
D013806:Theophylline; D009543:Nifedipine