title: Effects of different compositions of diets and chronic ethanol administration on proteolytic and antiproteolytic systems in the pancreatic tissue of rats.
abstract: The effects of dietary composition in combination with chronic ethanol ingestion on pancreatic proteolytic-antiproteolytic systems were studied by submitting 192 male Wistar rats to a 12-week dietary period. The rats were fed with a standard (S), fat-rich (F), protein-rich (P), or carbohydrate-rich (C) diet after randomized division into four groups. Half of the animals in each dietary group received water and the other half a mixture of 15% (v/v) ethanol and water as their drinking solution. The C-diet caused a significant increase of BAPNA hydrolysis, which was even more pronounced in rats receiving ethanol. Casein hydrolysis was increased significantly by the C-diet, but ethanol did not have any significant effect on this. Hydrolysis of ATEE was decreased significantly by the P- and C-diets, and ethanol in combination with the S- and F-diets decreased hydrolysis of ATEE in comparison with the corresponding water-receiving groups. The trypsin-inhibiting capacity of the pancreatic tissue was significantly increased in the group receiving C- and F-diets as compared to the S-diet-receiving group of animals. It seems that the composition of the consumed diet in combination with chronic ethanol ingestion may play a role in regulating the pancreatic proteolytic-antiproteolytic system. However, these changes were not parallel. The trypsin-inhibiting capacity of pancreatic tissue was also affected by the quality of the diet.
authors.forename: O J
authors.initials: OJ
authors.lastname: Rämö
authors.forename: P
authors.initials: P
authors.lastname: Jalovaara
authors.forename: L K
authors.initials: LK
authors.lastname: Korhonen
mesh_terms: D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism*; D011480:Protease Inhibitors / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D011480:Protease Inhibitors; D010447:Peptide Hydrolases