title: Continuous 24-hour intragastric pH monitoring in the evaluation of the effect of a nightly dose of famotidine, ranitidine and placebo on gastric acidity of patients with duodenal ulcer.
abstract: In 11 duodenal ulcer patients, the antisecretory effects of bedtime famotidine 40 mg were compared to those obtained with ranitidine 300 mg and placebo by means of continuous 24-hour intragastric pH monitoring. The 24-hour areas under the curve of pH profiles of the two H2 blockers were significantly different from those related to placebo (p approximately 0 for ranitidine and p = 0.00001 for famotidine), but not from each other (p = 0.51). Onset and duration of the famotidine action, however, were respectively earlier and longer lasting (12 vs. about 9 h) than those of ranitidine. Famotidine was also significantly superior (p approximately 0) to ranitidine in keeping intragastric pH at high values (especially those comprised between 6 and 8 pH units), although theoretically equipotent doses of the two H2 antagonists were used.
authors.forename: V
authors.initials: V
authors.lastname: Savarino
authors.forename: G S
authors.initials: GS
authors.lastname: Mela
authors.forename: P
authors.initials: P
authors.lastname: Scalabrini
authors.forename: E
authors.initials: E
authors.lastname: Di Timoteo
authors.forename: M R
authors.initials: MR
authors.lastname: Magnolia
authors.forename: G
authors.initials: G
authors.lastname: Celle
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000378:metabolism; D015738:Famotidine; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011899:Ranitidine / Q000627:therapeutic use*; D013844:Thiazoles / Q000627:therapeutic use*
chemical_list: D000897:Anti-Ulcer Agents; D013844:Thiazoles; D015738:Famotidine; D011899:Ranitidine