title: Paldimycins A and B and antibiotics 273a2 alpha and 273a2 beta. Synthesis and characterization.
abstract: Paldimycin (antibiotic 273a1) and antibiotic 273a2 as well as their individual components, paldimycins A (273a1 alpha) and B (273a1 beta) and antibiotics 273a2 alpha and 273a2 beta were synthesized from paulomycin, paulomycin A and paulomycin B, respectively, by reacting with N-acetyl-L-cysteine. The semisynthetic antibiotics had chromatographic behavior (TLC, HPLC) and physical and chemical properties identical to the properties of the corresponding antibiotics produced by Streptomyces paulus.
authors.forename: A D
authors.initials: AD
authors.lastname: Argoudelis
authors.forename: L
authors.initials: L
authors.lastname: Baczynskyj
authors.forename: S A
authors.initials: SA
authors.lastname: Mizsak
authors.forename: F B
authors.initials: FB
authors.lastname: Shilliday
authors.forename: P A
authors.initials: PA
authors.lastname: Spinelli
authors.forename: J
authors.initials: J
authors.lastname: DeZwaan
mesh_terms: D000111:Acetylcysteine / Q000031:analogs & derivatives; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D004187:Disaccharides; D006020:Glycopeptides / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D013053:Spectrophotometry; D013211:Staphylococcus aureus / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D004187:Disaccharides; D006020:Glycopeptides; D007202:Indicators and Reagents; C052531:paldimycin B; C052530:paldimycin A; D000111:Acetylcysteine