Effects of captopril on the physical work capacity of normotensive patients with stable-effort angina pectoris.
Twelve normotensive patients with coronary artery disease and stable effort-induced angina pectoris were selected: the antiischemic effect of captopril was studied. A maximal cycloergometer effort test was obtained before (base) and after administration of placebo or captopril (50 mg p.o.). The following parameters were measured: heart rate (HR), blood pressure (BP), maximal rate/pressure product (MRPP), maximal workload sustained, (MWS), maximal working time (MWT), and S-T depression at MRPP. The base and placebo were similar. Compared to them captopril augmented the MWT, increased the MWS, reduced S-T depression at MRPP, and decreased the number of patients with effort-induced angina pectoris. The antiischemic effect of captopril seems related both to its effect on HR and BP, and to a local enhancement of coronary blood flow.
Strozzi
C
C
Cocco
G
G
Portaluppi
F
F
Urso
L
L
Alfiero
R
R
Tasini
M T
MT
Montanari
L
L
Al Yassini
K
K
Rizzo
A
A
D000787:Angina Pectoris / Q000188:drug therapy*; D002216:Captopril / Q000627:therapeutic use*; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion / Q000187:drug effects*
D002216:Captopril