Demonstration of immunoreactive eosinophil granule major basic protein in the plasma and placentae of non-human primates.
A protein immunologically identical to the major basic protein (MBP) of eosinophil granules is present in the plasma of pregnant women and has been localized to human placental X cells using immunofluorescence. This study demonstrates the presence of similar immunoreactive molecules in the placental X cells from several non-human primates. We also describe the presence of increased plasma levels of MBP in the pregnant gorilla and in pregnant cynomolgus and rhesus monkeys as compared to non-pregnant counterparts. Such findings suggest that non-human primates are a suitable animal model for the study of the X cell function and in particular the physiological importance of MBP in pregnancy.
Wasmoen
T L
TL
Department of Immunology, Mayo Clinic, Rochester, MN.
Benirschke
K
K
Gleich
G J
GJ
D000818:Animals; D001798:Blood Proteins / Q000276:immunology / Q000378:metabolism*; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D006071:Gorilla gorilla; D008252:Macaca fascicularis; D008253:Macaca mulatta; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011863:Radioimmunoassay; D012260:Ribonucleases
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D012260:Ribonucleases