title: The effect of captopril on cutaneous blood flow in patients with primary Raynaud's phenomenon.
abstract: Fifteen patients with primary Raynaud's phenomenon received captopril 25 mg or placebo, three times daily for 6 weeks, in a randomized double-blind cross-over study. Compared with placebo, captopril produced a significant improvement in cutaneous blood flow but did not alter the frequency or severity of attacks of Raynaud's phenomenon.
authors.affiliation: Department of Dermatology, Middlesex Hospital, London, U.K.
authors.forename: M H
authors.initials: MH
authors.lastname: Rustin
authors.forename: N E
authors.initials: NE
authors.lastname: Almond
authors.forename: J A
authors.initials: JA
authors.lastname: Beacham
authors.forename: R J
authors.initials: RJ
authors.lastname: Brooks
authors.forename: D P
authors.initials: DP
authors.lastname: Jones
authors.forename: E D
authors.initials: ED
authors.lastname: Cooke
authors.forename: P M
authors.initials: PM
authors.lastname: Dowd
mesh_terms: D000328:Adult; D002216:Captopril / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D011897:Random Allocation; D011928:Raynaud Disease / Q000188:drug therapy* / Q000503:physiopathology; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply*
chemical_list: D002216:Captopril