title: Induction of the SOS response by new 4-quinolones.
abstract: The 4-quinolones ciprofloxacin, difloxacin, enoxacin, norfloxacin, ofloxacin, and nalidixic acid were found to induce the SOS response in qualitative and quantitative tests on Escherichia coli K12 containing the sfiA::lacZ gene fusion. Maximum induction of the SOS-response was observed with the quinolone concentrations that produced the most killing. There was also a modest increase in the rate of mutation in the lactose and galactose operons in a GalE- background, provided there was a functioning SOS system.
authors.affiliation: Department of Microbiology, Hospital Ramon y Cajal, Madrid, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Phillips
authors.forename: E
authors.initials: E
authors.lastname: Culebras
authors.forename: F
authors.initials: F
authors.lastname: Moreno
authors.forename: F
authors.initials: F
authors.lastname: Baquero
mesh_terms: D004260:DNA Repair / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D008826:Microbial Sensitivity Tests; D009153:Mutagens; D011804:Quinolines / Q000494:pharmacology*; D013014:SOS Response, Genetics / Q000187:drug effects*
chemical_list: D009153:Mutagens; D011804:Quinolines