IL 1 and bacterial lipopolysaccharide increase the ability of human endothelial cells to bind peripheral blood monocytes.
Human endothelial cells (EC) exposed to human recombinant IL 1 and to bacterial lipopolysaccharide (LPS) demonstrated a time dependent increase in their ability to bind peripheral blood monocytes (M0). The enhancement of endothelial-M0 interactions was shown to represent a direct alteration of EC and was not explained by IL 1 and LPS affecting M0. Other experiments indicated that the enhancement represented an acceleration in EC binding of M0 suggesting that EC may play a role in initiating proinflammatory events prior to the recruitment of inflammatory cells by chemotactic peptides.
Downs
E C
EC
Department of Physiological Chemistry, Ohio State University 43210.
Cornwell
D G
DG
Proctor
V K
VK
Whisler
R L
RL
D002448:Cell Adhesion / Q000187:drug effects*; D002478:Cells, Cultured; D004727:Endothelium / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D007700:Kinetics; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D012486:Salmonella typhimurium
D007375:Interleukin-1; D008070:Lipopolysaccharides