Polymorphous light eruption: experimental reproduction of skin lesions by whole-body UVA irradiation.
Fifty patients suffering from polymorphous light eruption (PLE), selected by criteria pointing to UVA sensitivity, were phototested with 2 different polychromatic UVA sources for reproduction of skin lesions. To simulate natural conditions, the patients were whole-body irradiated for up to 5 consecutive days. In 64% of the patients successful reproduction of PLE lesions was obtained by 1 to 4 irradiations. The total dosage ranged from 20 to 280 J/cm2, and the total exposure times from 10 to 60 min. Our results suggest that irradiation of the whole body in UVA-sensitive PLE patients does not provide more convincing test results than phototesting of small previously involved skin sites, as has been done by other groups.
Neumann
R A
RA
Department of Dermatology II, University of Vienna, Austria.
Pohl-Markl
H
H
Knobler
R M
RM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D008027:Light / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011833:Radiation Injuries, Experimental; D012867:Skin / Q000528:radiation effects; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014916:Whole-Body Irradiation