R 8110, a new short-acting hypnotic in dogs.
The clinical, respiratory and cardiovascular effects of intravenous injections of R 8110, a fluor analogue of etomidate, were studied in unpremedicated dogs. Clinical observations were carried out after intravenous injections of 3 and 4 mg kg-1 of R 8110. Cardiovascular studies were conducted after an intravenous injection of 3 mg kg-1. The drug proved to be a safe and reliable agent for induction and produced a short-lasting hypnosis and some analgesia. Both induction and recovery were smooth and rapid. Heart rate and systolic and diastolic blood pressure decreased significantly (P less than or equal to 0.05) 10 minutes after injection; the influence on arterial blood parameters was minimal.
van Dijk
P
P
Degryse
A D
AD
Ooms
L A
LA
Lagerweij
E
E
D000768:Anesthesia, General / Q000662:veterinary; D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs / Q000502:physiology*; D005045:Etomidate / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007385:Intermittent Positive-Pressure Ventilation / Q000662:veterinary; D008297:Male; D012119:Respiration / Q000187:drug effects*
D006993:Hypnotics and Sedatives; C052803:R 8110; D005045:Etomidate