title: Placebo-controlled trial of cisapride in postoperative ileus.
abstract: The effect of 4 mg of the gastrointestinal motility enhancing agent cisapride on postoperative ileus was compared with that of a placebo in 53 patients who had undergone various types of surgery. They received one i.v. injection of the double-blind medication, or two if no distinct flatus occurred within an hour after the first injection. The placebo response was very limited; borborygmi or flatus did not occur in more than 12% of the patients not even after the second injection. Cisapride was significantly effective: bowel sounds were present in 43% and 50% within 1 hour after the first and second injection of 4 mg, respectively, and flatus in 36% and 43%. The recognition that colon inactivity probably is the major determinant of the ileus, may be indicative of a substantial relative impact of cisapride's stimulating effects on colon motility.
authors.affiliation: O. L. Vrouw Hospital, Aalst, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Boghaert
authors.forename: G
authors.initials: G
authors.lastname: Haesaert
authors.forename: P
authors.initials: P
authors.lastname: Mourisse
authors.forename: M
authors.initials: M
authors.lastname: Verlinden
mesh_terms: D000328:Adult; D020117:Cisapride; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007415:Intestinal Obstruction / Q000188:drug therapy; D008297:Male; D010880:Piperidines / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy*
chemical_list: D010880:Piperidines; D020117:Cisapride