[Antitumor effect of carboplatin and iproplatin on human urinary bladder and prostatic cancers grown in nude mice].
Antitumor effects of carboplatin and iproplatin, a second-generation cisplatin analog were studied using cisplatin sensitive human urinary bladder (NM-B-1) and prostatic cancers (PRO-1) grown in nude mice. Both NM-B-1 and PRO-1 were sensitive to carboplatin and iproplatin. The tumor-regression effect of carboplatin at the fourfold dose of cisplatin was comparable to that of cisplatin. Iproplatin at the eight to sixteen times dose of cisplatin showed a comparable tumor regression to cisplatin. The range of effective dose was wider in carboplatin than cisplatin and that of iproplatin was not so wide as cisplatin.
Hasegawa
J
J
Dept. of Urology, Nippon Medical School, Tokyo.
Kawamura
N
N
Yamada
S
S
Tsuboi
N
N
Akimoto
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016190:Carboplatin; D002945:Cisplatin / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D014183:Transplantation, Heterologous; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C023359:iproplatin; D016190:Carboplatin; D002945:Cisplatin