title: Characteristics and functions of Na-K-Cl cotransport in epithelial tissues.
abstract: This review summarizes our present understanding of Na-K-Cl cotransport and its physiological role in absorption and secretion of electrolytes and water in epithelial tissues. In the past several years an extensive literature about this cotransporter has developed due to its widespread distribution in a variety of cell types and its essential role in fluid and electrolyte transport in several epithelial tissues. We summarize this literature and speculate on the future characterization of this transport system. Although this review focuses on cotransport as it relates to absorptive and secretory processes in epithelia, important information concerning the pharmacology, stoichiometry, and regulation of Na-K-Cl cotransport in nonepithelial systems (i.e., erythrocytes, fibroblasts, squid axon, etc.) has been included to supplement areas that are less well established in the epithelial literature.
authors.forename: S M
authors.initials: SM
authors.lastname: O'Grady
authors.forename: H C
authors.initials: HC
authors.lastname: Palfrey
authors.forename: M
authors.initials: M
authors.lastname: Field
mesh_terms: D000345:Affinity Labels; D000818:Animals; D002034:Bumetanide / Q000378:metabolism; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002412:Cations / Q000494:pharmacology; D004848:Epithelium / Q000378:metabolism*; D005544:Forecasting; D011189:Potassium Chloride / Q000378:metabolism; D049992:Sodium Chloride Symporters; D028021:Sodium-Potassium-Chloride Symporters; D027981:Symporters; D014316:Tritium
chemical_list: D000345:Affinity Labels; D002352:Carrier Proteins; D002412:Cations; D049992:Sodium Chloride Symporters; D028021:Sodium-Potassium-Chloride Symporters; D027981:Symporters; D002034:Bumetanide; D014316:Tritium; D011189:Potassium Chloride