Malotilate reduces collagen synthesis and cell migration activity of fibroblasts in vitro.
Diisopropyl-1,3-dithiol-2-ylidenemalonate (malotilate) was studied for and compared with cyanidanol, hydrocortisone and colchicin on its impact on fibroblast cultures. Under in vitro conditions, malotilate specifically reduces collagen synthesis of fibroblasts. In addition, malotilate is an efficient inhibitor of fibroblast migration as tested by a chemotaxis assay in a modified Boyden chamber. Our data may support the notion that malotilate is of potential interest for interfering with fibrotic processes.
Poeschl
A
A
Max-Planck-Institut fuer Biochemie, Martinsried, Federal Republic of Germany.
Rehn
D
D
Dumont
J M
JM
Mueller
P K
PK
Hennings
G
G
D002392:Catechin / Q000494:pharmacology; D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects*; D003078:Colchicine / Q000494:pharmacology; D003094:Collagen / Q000096:biosynthesis*; D005347:Fibroblasts / Q000187:drug effects; D005455:Fluorescent Antibody Technique; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D008314:Malonates / Q000494:pharmacology*
D008314:Malonates; D002392:Catechin; D003094:Collagen; C024808:diisopropyl 1,3-dithiol-2-ylidenemalonate; D003078:Colchicine; D006854:Hydrocortisone