title: N-methyl-N'-nitro-N-nitrosoguanidine-induced resistance to ionizing radiation.
abstract: N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) pretreatments increase the resistance of Escherichia coli to gamma-radiation. The increased resistance is dependent on functional polA, recA, recB, recC, and lexA genes and is partly dependent on recN. The MNNG-induced resistance is additive to resistance induced by pretreatment with gamma-radiation but not by increases induced by hydrogen peroxide. The MNNG-induced resistance occurs in adaptive response mutants and at pretreatment levels of MNNG that do not activate cells to reactivate UV-inactivated lambda phage. The MNNG-induced resistance appears to be distinct from other inductions to gamma-radiation resistance.
authors.forename: M L
authors.initials: ML
authors.lastname: Morse
authors.forename: D S
authors.initials: DS
authors.lastname: Smith
mesh_terms: D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development / Q000528:radiation effects*; D005720:Gamma Rays; D005838:Genotype; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D011837:Radiation-Protective Agents; D012293:Rifampin / Q000494:pharmacology; D013045:Species Specificity
chemical_list: D011837:Radiation-Protective Agents; D008769:Methylnitronitrosoguanidine; D012293:Rifampin