Short-term prophylaxis with cefuroxime in colorectal surgery for cancer.
A controlled study of short-term prophylaxis with cefuroxime was performed on a group of 52 patients with colorectal neoplasms who underwent elective surgery. The patients were divided into two groups, A and B. Group A received the antibiotic immediately before surgery, intraincisionally and immediately after the end of operation; group B was treated only postoperatively. Each patient received a total of 5,250 mg of cefuroxime. Wound sepsis was demonstrated in 11.5% of cases of group A and 23.0% of group B (P less than 0.01); another type of sepsis was observed in 34% of group A and 11.5% of group B (P less than 0.001). There was no difference in the operative mortality in the two groups.
Colizza
S
S
De Fazio
S
S
Addari
A
A
Grande
R
R
Cucchiara
G
G
D002444:Cefuroxime / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007430:Intraoperative Care; D008875:Middle Aged; D011182:Postoperative Care; D011292:Premedication; D012004:Rectal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control; D013997:Time Factors
D002511:Cephalosporins; D002444:Cefuroxime