[Study of the participation of the alpha-chain of the LFA-1 antigen in the phenomenon of lymphocyte adherence inhibition using ICO-11 monoclonal antibodies in vitro].
The influence of monoclonal antibodies (Mabs) ICO-11 on the ability of lymphocytes from breast cancer patients to react in lymphocyte adherence inhibition (LAI) test has been studied in vitro. It has been demonstrated that Mabs ICO-11 in the dilutions 1/4 and higher blocked the reaction to tumor extracts in LAI-test, without affecting the reaction to the extracts of normal tissues and a spontaneous adhesion of lymphocytes of healthy donors as well. The addition of the control supernatants of myeloma cells X63.Ag8. 653 to the test-system in the same dilutions caused no influence upon LAI-reaction and spontaneous adhesion of lymphocytes from healthy donors. A possible participation of alpha-chains of function-associated antigens in the binding of tumor-associated antigens to T-cells in the inductive phase of the reaction of lymphocyte adherence inhibition in vitro has been suggested.
Kharkevich
D D
DD
Baryshnikov
A Iu
AIu
Savel'eva
E V
EV
Polevaia
E B
EB
Kadagidze
Z G
ZG
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology; D005260:Female; D006801:Humans; D007158:Immunologic Techniques; D066298:In Vitro Techniques; D007957:Leukocyte Adherence Inhibition Test; D016169:Lymphocyte Function-Associated Antigen-1
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D016169:Lymphocyte Function-Associated Antigen-1
Izuchenie uchastiia al'fa-tsepi LFA-1-antigena v fenomene ingibitsii adgezii limfotsitov s pomoshch'iu monoklonal'nykh antitel IKO-11 in vitro.