title: Preservation of pathology specimens by silicone plastination. An innovative adjunct to pathology education.
abstract: The authors have used the process of plastination to preserve gross anatomic specimens for teaching purposes. A specimen is fixed in 10% buffered formalin and dehydrated in increasing grades of ethanol. Thereafter it is saturated with methylene chloride and then impregnated in vacuo at -20 degrees C with silicone rubber. Final steps involve drainage and exposure to a curing agent. The total time required is approximately 16 weeks. The finished plastinated specimen is dry to the touch, odorless, and nontoxic, yet it maintains its original shape and, in many cases, is reasonably close in color and consistency. It resists deterioration and can be stored at room temperature indefinitely. The authors have found plastinated specimens to be superior to those preserved in formalin for teaching anatomic pathology to undergraduate medical students.
authors.forename: H C
authors.initials: HC
authors.lastname: Bickley
authors.forename: A N
authors.initials: AN
authors.lastname: Walker
authors.forename: R L
authors.initials: RL
authors.lastname: Jackson
authors.forename: R S
authors.initials: RS
authors.lastname: Donner
mesh_terms: D003365:Costs and Cost Analysis; D006652:Histological Techniques; D006801:Humans; D010336:Pathology / Q000193:education*; D012828:Silicones / Q000494:pharmacology; D014021:Tissue Preservation / Q000379:methods*
chemical_list: D012828:Silicones