[Relation between hormones of the hypothalamo-hypophyseal-gonadal system and peripheral blood serotonin levels].
The LHRH, human chorionic gonadotropin (hCG) or testosterone affected the peripheral serotonin (5HT) concentration in the blood. I. p. injection of LHRH or hCG resulted in an increase of testosterone and in a decrease of 5HT levels in the blood. The influence of these peptides on the 5HT concentration in the peripheral blood appears to be complex. On the one hand, the 5HT level depended on the level of testosterone in the blood since castration was followed by an increase of the 5HT content in the blood. On the other hand, treatment of the castrated mice with hCG resulted in an increase of the blood 5HT concentration as wall. The GHs seem to exert multiple effect on peripheral 5HT including both a direct effect and their action through testosterone.
Serova
L I
LI
Kudriavtseva
N N
NN
Popova
N K
NK
Naumenko
E V
EV
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009919:Orchiectomy; D012701:Serotonin / Q000097:blood*; D013737:Testis / Q000502:physiology*; D013739:Testosterone / Q000097:blood / Q000494:pharmacology
D006063:Chorionic Gonadotropin; D012701:Serotonin; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone
Vzaimosviaz' mezhdu gormonami gipotalamo-gipofizarno-polovoĭ sistemy i urovnem serotonina v periferichskoĭ krovi.