Recurrent sickle cell nephropathy in a transplanted kidney.
Of patients who developed end-stage renal disease secondary to sickle cell anemia (SCA), some have undergone renal transplantation with reasonable success. We recently cared for a patient with SCA and a functioning, transplanted kidney who experienced a permanent decline in renal function three and one-half years following transplant. The evaluation of his renal dysfunction revealed multiple features to support recurrence of sickle cell nephropathy as the cause for the deterioration.
Miner
D J
DJ
Department of Medicine, University of Pennsylvania, Philadelphia 19104.
Jorkasky
D K
DK
Perloff
L J
LJ
Grossman
R A
RA
Tomaszewski
J E
JE
D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000473:pathology; D001706:Biopsy; D006801:Humans; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000628:therapy; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008297:Male; D008854:Microscopy, Electron; D012008:Recurrence