title: Five year results of a randomized trial of adjuvant 5-fluorouracil and levamisole in colorectal cancer.
abstract: Following curative surgery for colorectal cancer 141 patients were randomized to receive a 6 month course of 5-fluorouracil (5FU) with or without postoperative levamisole or supportive treatment only. The patients have been followed up for a minimum of 5 years and 52 per cent of patients in the control group, 44 per cent of the 5FU group and 32 per cent of the 5FU/levamisole group have died of tumour recurrence. This represents a significant survival advantage in the patients receiving levamisole, even when other patient and tumour factors are allowed for.
authors.forename: R
authors.initials: R
authors.lastname: Windle
authors.forename: P R
authors.initials: PR
authors.lastname: Bell
authors.forename: D
authors.initials: D
authors.lastname: Shaw
mesh_terms: D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007961:Leukocyte Migration-Inhibitory Factors; D007978:Levamisole / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011184:Postoperative Period; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery
chemical_list: D007961:Leukocyte Migration-Inhibitory Factors; D007978:Levamisole; D005472:Fluorouracil