title: [2 cases of multiresistant Plasmodium falciparum malaria contracted in Douala with atypical clinical presentation].
abstract: We present two cases of Plasmodium falciparum malaria contracted in Douala despite adequate prophylaxis by Fansidar for one and by chloroquine for the other. Failure of curative treatment by Fansidar for the first case (in vitro chloroquine-resistant strain) and by amodiaquine plus erythromycin for the second. After these therapeutic failures, both patients presented without fever, but with splenomegaly and anaemia. The successful therapeutic was mefloquine.
authors.affiliation: Hôpital de l'Institut Pasteur, Paris.
authors.forename: G
authors.initials: G
authors.lastname: Charmot
authors.forename: F
authors.initials: F
authors.lastname: Simon
authors.forename: J
authors.initials: J
authors.lastname: Le Bras
mesh_terms: D000293:Adolescent; D000328:Adult; D000655:Amodiaquine / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D002163:Cameroon; D002738:Chloroquine / Q000627:therapeutic use; D004338:Drug Combinations / Q000627:therapeutic use; D004351:Drug Resistance; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology*; D008297:Male; D015767:Mefloquine; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000627:therapeutic use; D011804:Quinolines / Q000627:therapeutic use; D013413:Sulfadoxine / Q000627:therapeutic use
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; D011804:Quinolines; D000655:Amodiaquine; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D002738:Chloroquine; D015767:Mefloquine; D011739:Pyrimethamine
vernacular_title: Deux cas de paludisme à Plasmodium falciparum multirésistant contractés à Douala avec présentation clinique atypique.