title: The relationship of drug use to denture function and saliva flow rate in a geriatric population.
abstract: This study investigated an "old elderly" population and the relationships between the use of hyposalivatory drugs and denture function, including saliva flow rates and denture-supporting structures and health. There was a high prevalence of drug use and medical problems. Hyposalivatory drugs were prescribed for more than half of the subjects. There was a significant relationship between increased hyposalivatory drug use and reduced saliva flow rates. Reduced values for denture-supporting structures were found to be related to increased medical problems and hyposalivatory drug use. Reduced values for denture-supporting tissue health were found to be related to masticatory performance and retention and stability. Bite force showed a strong positive relationship with masticatory performance. Some of the subjective evaluations by the subjects showed statistically significant relationship with their respective objective measures: perceptions of dry mouth were related to saliva flow rates, perceptions of denture rocking or looseness were related to retention and stability ratings, and reports of pain on chewing were related to masticatory performance. It may be concluded that the use of drugs with hyposalivatory side effects may have a deleterious influence on the denture-bearing tissue. Direct influence on denture function, however, was not found. These findings provide valuable insights into the effects of drug usage in old age and their impact on oral health and denture function. Diagnostic and treatment capabilities are thus enhanced in that physicians, pharmacists, and other health-related professionals can be alerted to the problems accompanying hyposalivatory drug use. This may permit alternatives in medication when possible, and dentists may more effectively plan and conduct prosthodontic care for these individuals.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.forename: J M
authors.initials: JM
authors.lastname: Kreher
authors.forename: G N
authors.initials: GN
authors.lastname: Graser
authors.forename: S L
authors.initials: SL
authors.lastname: Handelman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001732:Bite Force; D003781:Denture Retention; D003824:Denture, Complete; D004358:Drug Therapy; D005260:Female; D006801:Humans; D007575:Jaw, Edentulous / Q000503:physiopathology*; D008297:Male; D008409:Mastication; D009061:Mouth Mucosa / Q000033:anatomy & histology; D012463:Saliva / Q000502:physiology*; D012636:Secretory Rate / Q000187:drug effects