[Beta interferon therapy in hairy cell leukemia].
Eleven patients with histologically proven hairy-cell leukemia were treated for 2 to 6 months with a natural beta-interferon (beta-IFN) preparation (3 X 4 million units week i.v.). Three of the eight evaluable patients experienced a partial response, two a minor response, and three no improvement. A reduction of the hairy-cell infiltration of the bone marrow was observed in one patient. Typical IFN side-effects with flu-like symptoms were noted. These results demonstrate that IFN-beta has some clinical efficacy in hairy-cell leukemia.
von Wussow
P
P
Dühlmann
J
J
Grethlein
T
T
Hirschmann
W D
WD
Hügl
E
E
Koch
O
O
Martin
W R
WR
Pees
H W
HW
Urbanitz
W
W
Freund
M
M
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects / Q000627:therapeutic use*; D007943:Leukemia, Hairy Cell / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction
D007370:Interferon Type I
IFN-beta-Therapie bei der Haarzelleukämie.