[New knowledge of the modifiability of QRS amplitudes of the surface electrocardiogram of the transplanted human heart].
Applying immunosuppressive therapy with Ciclosporin A, the myocardium shows only little or no oedema in the cardiac rejection process. Thus the usefulness of electrocardiographic diagnosis using QRS-amplitudes of the surface electrocardiogram (unipolar precordial chest leads) for the early recognition of the (acute) cardiac rejection process, is considerably limited if not questionable when compared with the pre-ciclosporin period (63 cases with heart transplants). In a heart-lung transplant for instance a massive accumulation of fluid in the lungs (erroneously) can influence the QRS-amplitudes. In addition, the cardiac rejection index (KRI) obtained by unipolar chest leads and other electrocardiographic alterations should be watched continuously. With a high degree of reliance, the intra-myocardial electrogram (IMEG) permits a better diagnosis of the acute cardiac rejection process. For the early clinical diagnosis the use of additional noninvasive methods of examinations is advisable.
Kriehuber
E A
EA
D001145:Arrhythmias, Cardiac / Q000175:diagnosis*; D003524:Cyclosporins / Q000627:therapeutic use; D004562:Electrocardiography; D006084:Graft Rejection / Q000187:drug effects; D016027:Heart Transplantation; D006801:Humans; D011183:Postoperative Complications / Q000175:diagnosis*
D003524:Cyclosporins
Neue Erkenntnisse über die Beeinflussbarkeit der QRS-Amplituden des Oberflächenelektro-kardiogramms von transplantierten Menschenherzen.