title: Identification of the gene for the yeast ribonucleotide reductase small subunit and its inducibility by methyl methanesulfonate.
abstract: We have identified, cloned, and sequenced the gene for the small subunit of ribonucleotide diphosphate reductase of Saccharomyces cerevisiae. The protein and its transcript are induced about 10-fold by the alkylating agent methyl methanesulfonate, a result which suggests that the gene is induced by DNA damage.
authors.affiliation: Section of Biochemistry, Molecular & Cell Biology, Cornell University, Ithaca, New York 14853.
authors.forename: H K
authors.initials: HK
authors.lastname: Hurd
authors.forename: C W
authors.initials: CW
authors.lastname: Roberts
authors.forename: J W
authors.initials: JW
authors.lastname: Roberts
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D003429:Cross Reactions; D004249:DNA Damage; D005786:Gene Expression Regulation / Q000187:drug effects*; D005796:Genes; D005800:Genes, Fungal; D008741:Methyl Methanesulfonate / Q000494:pharmacology*; D008969:Molecular Sequence Data; D011938:Rec A Recombinases / Q000235:genetics; D012264:Ribonucleotide Reductases / Q000235:genetics* / Q000276:immunology; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D008741:Methyl Methanesulfonate; D012264:Ribonucleotide Reductases; D011938:Rec A Recombinases