[The system of evaluation of changes in the epithelial reticulum in the physiological and pathological transformation of the thymus gland].
The system for the immunomorphological evaluation of the degree of the human and animal thymus transformation is suggested. The degree of the epithelium demasking and the character of lymphocyte emigration were revealed due to the increase of the surface and alteration of the size of epithelial cells which under normal conditions are completely screened by lymphocytes. This was done by means of the fluorescent antibodies to the cells of epithelial reticulum of the thymic lobule cortex and some cells of the medulla layer (prekeratins). This system permits a more circumstantial characteristics of the histological changes in the thymus when the cortical part of the lobule loses the capacity for lymphocyte retention in the epithelial reticulum.
Beliaev
D L
DL
Beletskaia
L B
LB
D000818:Animals; D006224:Cricetinae; D004062:DiGeorge Syndrome / Q000276:immunology / Q000473:pathology; D004848:Epithelium / Q000276:immunology / Q000473:pathology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D051379:Mice; D011817:Rabbits; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology*
D007166:Immunosuppressive Agents
Sistema otsenki izmeneniĭ épitelial'nogo retikuluma pri fiziologicheskoĭ i patologicheskoĭ transformatsii timusa.