Insulin-induced drinking: an analysis of the involvement of renal angiotensin II and insulin-induced changes in plasma volume.
Male Long-Evans rats were used to investigate the potential hydrational mechanisms underlying insulin-induced drinking (IID). Plasma volume effects of insulin were assessed using both hematocrit and dye dilution procedures. Evidence is presented indicating that insulin produces a long-lasting and dose-dependent reduction in plasma volume. However, it does not appear that the drinking response is tightly tied to the reduced plasma volume because a 50% blockade of this effect does not reduce water intake. In addition, it does not appear that insulin-induced drinking is related to a release of renal angiotensin because IID is not blocked by nephrectomy. The mechanism underlying IID may be related to the activation of the recently described brain insulin receptor system.
Waldbillig
R J
RJ
Department of Psychology, University of Florida, Gainesville.
Bartness
T J
TJ
D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D004326:Drinking / Q000187:drug effects*; D007201:Indicator Dilution Techniques; D007328:Insulin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D007677:Kidney Function Tests; D008297:Male; D009392:Nephrectomy; D010953:Plasma Volume / Q000187:drug effects*; D051381:Rats; D013156:Splenectomy; D013997:Time Factors
D007328:Insulin; D000804:Angiotensin II