MK-801 powerfully protects against N-methyl aspartate neurotoxicity.
Using the ex vivo chick embryo retina to study the efficacy of antagonists in blocking the excitotoxic effects of excitatory amino acid agonists, we previously identified phencyclidine as the most powerful known anti-excitotoxin. Here we show that MK-801 is 5 times more powerful than phencyclidine as an anti-excitotoxin, that its antagonism is specific for N-methyl-asparate toxicity, is non-competitive and does not entail inhibition of excitatory amino acid receptor binding.
Olney
J
J
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Price
M
M
Salles
K S
KS
Labruyere
J
J
Frierdich
G
G
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000633:toxicity; D001345:Autoradiography; D001667:Binding, Competitive / Q000187:drug effects; D002642:Chick Embryo; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D005971:Glutamates / Q000378:metabolism; D007608:Kainic Acid / Q000633:toxicity; D016202:N-Methylaspartate; D009474:Neurons / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000927:Anticonvulsants; D003986:Dibenzocycloheptenes; D005971:Glutamates; D001224:Aspartic Acid; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; D007608:Kainic Acid