Cerebellar hemangioblastoma with prominent stromal astrocytosis: diagnostic and histogenetic considerations.
A cerebellar hemangioblastoma with atypical radiologic and morphologic features is reported. On computed tomography this tumor presented as a single ring-enhancing mass in the right cerebellar hemisphere without adjacent cyst formation. It was radiologically indistinguishable from an abscess or malignant neoplasm. Postmortem examination demonstrated a circumscribed, cystic neoplasm arising in the pia at the base of a sulcus. Microscopically, the tumor contained a prominent astrocytic component that mimicked the appearance of a highly vascular astrocytoma. Hemangioblastomas with this degree of astrocytosis are unusual. They must be distinguished pathologically from both cystic astrocytoma and mixed hemangioblastoma-glioma (angioglioma).
McComb
R D
RD
Department of Pathology, University of Nebraska Medical Center, Omaha 68105.
Eastman
P J
PJ
Hahn
F J
FJ
Bennett
D R
DR
D000368:Aged; D000369:Aged, 80 and over; D001253:Astrocytes / Q000473:pathology*; D002528:Cerebellar Neoplasms / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology; D003937:Diagnosis, Differential; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006394:Hemangiosarcoma / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D014057:Tomography, X-Ray Computed
D005904:Glial Fibrillary Acidic Protein