[Propofol versus methohexital in the surgery of the spinal canal].
The aim of this study was to compare the quality of postanaesthetic recovery after anaesthesia with methohexitone (M) or with propofol (P). Thirty patients undergoing spinal surgery were randomly assigned to either group. The induction dose was 2 mg . kg-1 for both M and P. Anaesthesia was maintained by continuous infusion. The rate was 0.15 mg . kg-1 . min-1 for P and 0.07 mg . kg-1 . min-1 for M. Analgesia was obtained with fentanyl with the same doses in both groups. The maintenance doses were subsequently decreased by 50 and 75% of the initial values. This work compared the quality induction and the criteria of recovery (Aldrete score, Newman test). In two patients in each group, sensory evoked potentials (SEP) were recorded to monitor neurological integrity. The quality of induction was similar in both groups. Awakening was significantly more rapid in group P. The SEP were much decreased in group P, whilst there were few changes in group M. Monitoring of medullar integrity is mandatory in spinal surgery, requiring a rapid recovery. This objective was obtained with shorter delays in patients anaesthetized with propofol than in those who had received methohexitone. However, the former, at the doses used, seemed to depress the SEP.
Destribats
B
B
Maurette
P
P
Castagnera
L
L
Esposito
J
J
Macouillard
G
G
Cantin
P
P
Héraut
L A
LA
D000328:Adult; D000762:Anesthesia Recovery Period; D000777:Anesthetics; D002986:Clinical Trials as Topic; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008723:Methohexital; D008875:Middle Aged; D010636:Phenols; D011184:Postoperative Period; D015742:Propofol; D013115:Spinal Canal / Q000601:surgery*
D000777:Anesthetics; D010636:Phenols; D008723:Methohexital; D015742:Propofol
Propofol versus méthohexital dans la chirurgie du canal rachidien.