Removal of the vomeronasal organ disrupts the activation of reproduction in female voles.
The reproductive system of female prairie voles remains quiescent in the absence of stimulation from males; however, chemosignals from males are capable of at least partially activating female reproduction. In other species, the vomeronasal system mediates some of the reproductive responses of females to males. We found that surgical removal of the vomeronasal organ (VNX) from adult female prairie voles impeded reproductive activation in response to pairing with stud males: ovarian and uterine weights of VNX females paired with stud males for 24 or 60 hours were significantly less than those of normal (NORMAL) or sham-operated (SHAM) females. Furthermore, 8 of 9 NORMAL, 10 of 13 SHAM, but only 4 of 9 VNX females paired with stud males for 60 hours mated. VNX females, however, were still able to use chemosensory cues to locate food. Behavioral observations of females encountering stud males were similar for VNX, SHAM and NORMAL females. We conclude that vomeronasal chemoreception may be a primary component of reproductive activation in female prairie voles, presumably by mediating neuroendocrine responses to chemosignals.
Lepri
J J
JJ
Monell Chemical Senses Center, Philadelphia, PA 19104.
Wysocki
C J
CJ
D000818:Animals; D003411:Arvicolinae / Q000502:physiology*; D001522:Behavior, Animal / Q000502:physiology*; D002628:Chemoreceptor Cells / Q000502:physiology*; D005260:Female; D008297:Male; D009300:Nasal Septum / Q000294:innervation / Q000502:physiology*; D009929:Organ Size; D010053:Ovary / Q000033:anatomy & histology / Q000502:physiology; D012098:Reproduction; D014599:Uterus / Q000033:anatomy & histology / Q000502:physiology