Enzymuria in carboplatin nephrotoxicity.
Urinary excretion of N-acetyl-beta-glucosaminidase (NAG) is an early marker of nephrotoxicity. NAG activity was assayed by the fluorimetric method of Leaback and Walker in 17 patients treated (22 courses) with carboplatin (CBDCA, 220-550 mg/m2) before infusion and 24, 48, 72 and 96 h after. Increased excretion of NAG, a sensitive index of renal tubular damage, was observed following 10 of the 22 courses. A transient increase in plasma creatinine and/or abnormal proteinuria was observed in 6 cases. Impaired renal function prior to therapy seems to be a predisposing factor to the nephrotoxicity.
Damiani
E
E
Clinica Medica, Università degli Studi di Milano-Ospedale L. Sacco, Italia.
Cattaneo
M T
MT
Sessa
C
C
Zucca
E
E
Cavalli
F
F
Bertolini
A
A
Libretti
A
A
Beretta
R
R
D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016190:Carboplatin; D004796:Clinical Enzyme Tests; D003404:Creatinine / Q000097:blood; D005260:Female; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D011507:Proteinuria / Q000139:chemically induced
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D003404:Creatinine; D016190:Carboplatin; D006596:Hexosaminidases; D000118:Acetylglucosaminidase