The role of T lymphocytes in autoimmune thyroid disease.
Abnormalities in cellular mechanisms of immunoregulation are important factors in the initiation and/or propagation of autoimmune thyroid disease and Graves' ophthalmopathy. The primary immunologic lesion, however, remains elusive despite increasingly sophisticated investigations in the areas of antigen presentation and subsequent T-cell responses. Emphasis on functional evaluations of relevant cell populations and advances in lymphokine analysis, interpretation of DR antigen expression, and T-cell cloning offer promise for our future understanding of this complex process.
Ahmann
A J
AJ
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
Burman
K D
KD
D000938:Antigen-Presenting Cells / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000276:immunology*
D006684:HLA-DR Antigens; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines