Progressive bile duct injury after thiabendazole administration.
A 27-yr-old man developed jaundice 2 wk after exposure to thiabendazole. Cholestasis persisted for 3 yr, at which time a liver transplant was performed. Two liver biopsy specimens and the hepatectomy specimen were remarkable for almost complete disappearance of interlobular bile ducts. Prominent fibrosis and hepatocellular regeneration were also present; however, the lobular architecture was preserved. This case represents an example of "idiosyncratic" drug-induced liver damage in which the primary target of injury is the bile duct. An autoimmune pathogenesis of the bile duct destruction is suggested.
Manivel
J C
JC
Bloomer
J R
JR
Snover
D C
DC
D000328:Adult; D001652:Bile Ducts / Q000187:drug effects* / Q000473:pathology; D002779:Cholestasis / Q000139:chemically induced* / Q000601:surgery; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D016031:Liver Transplantation; D008297:Male; D013827:Thiabendazole / Q000009:adverse effects*
D013827:Thiabendazole