The structure and function of progesterone receptors in breast cancer.
This paper is a review of the clinical role of progesterone receptors (PR) in the management of breast cancer, and the use of synthetic progestins in treatment of the metastatic disease. Also reviewed are our basic molecular studies dealing with the structure of human breast cancer PR, focusing on the two hormone binding proteins (the A- and B-receptors) and the role of phosphorylation. A model for the structure of PR and their subcellular compartmentalization following hormone treatment is presented.
Horwitz
K B
KB
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262.
D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D002467:Cell Nucleus / Q000032:analysis; D003600:Cytosol / Q000032:analysis; D004965:Estrogen Antagonists / Q000627:therapeutic use; D008970:Molecular Weight; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy / Q000378:metabolism*; D010766:Phosphorylation; D011374:Progesterone / Q000378:metabolism*; D011372:Progestins / Q000627:therapeutic use; D011379:Prognosis; D011485:Protein Binding; D011980:Receptors, Progesterone / Q000378:metabolism*
D004965:Estrogen Antagonists; D011372:Progestins; D011980:Receptors, Progesterone; D011374:Progesterone