title: Effect of immunization with Escherichia coli K1 antigen on the course of experimental infection of the urinary tract of the rat.
abstract: The influence of vaccination with an immunogenic K1 antigen of Escherichia coli on the course of pyelonephritis induced experimentally in rats by infection with Escherichia coli O2:K1:H4 was investigated. The immunogenic properties of K1 antigen are poor. A conjugate of K1 antigen with bovine serum albumin (BSA) was therefore tested. Preliminary experiments showed that the K1-BSA conjugate is immunogenic. Renal inflammatory activity in rats after retrograde infection was significantly reduced after vaccination of the animals with K1-BSA conjugate within six weeks of infection.
authors.affiliation: Institute of Microbiology, Medical School of the Wilhelm Pieck University, Rostock, GDR.
authors.forename: E
authors.initials: E
authors.lastname: Straube
authors.forename: W
authors.initials: W
authors.lastname: Nimmich
authors.forename: U
authors.initials: U
authors.lastname: Broschewitz
authors.forename: G
authors.initials: G
authors.lastname: Naumann
authors.forename: K
authors.initials: K
authors.lastname: Hacker
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000942:Antigens, Bacterial; D016667:Bacterial Capsules; D001428:Bacterial Vaccines / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology; D004927:Escherichia coli Infections / Q000276:immunology*; D022361:Escherichia coli Vaccines; D005260:Female; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D012710:Serum Albumin, Bovine / Q000276:immunology; D014552:Urinary Tract Infections / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D022361:Escherichia coli Vaccines; D011135:Polysaccharides, Bacterial; C036962:capsular polysaccharide K1; D012710:Serum Albumin, Bovine