Application of toxico-kinetic criteria as a basis for toxicometric parameters.
In an experiment with single exposure to benzene and styrene at a level corresponding, to the threshold of harmful effect established by functional indices the intensity of metabolism was found to decrease. Toxico-kinetic characteristics of the substance in a single experiment permit us to prognosticate the risk of developing chronic intoxication. In comparison with indices characterizing general state of the organism, toxicokinetic indices enhance the reliability of toxicometric parameters used in determining Mac's for the air of the working area.
Ulanova
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Avilova
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D000395:Air Pollutants, Occupational / Q000633:toxicity*; D000397:Air Pollution / Q000032:analysis*; D000818:Animals; D001554:Benzene / Q000378:metabolism / Q000633:toxicity; D007700:Kinetics; D019800:Phenol; D010636:Phenols / Q000652:urine; D051381:Rats; D013343:Styrenes / Q000633:toxicity
D000395:Air Pollutants, Occupational; D010636:Phenols; D013343:Styrenes; D019800:Phenol; D001554:Benzene