[Immunoenzyme detection of autoantibodies to the surface of pancreatic islet cells in diabetes mellitus and in increased risk of its development].
The authors described the use of an enzyme-linked immunosorbent assay to determine islet cell surface antibodies (ICSA) in persons at high risk of developing insulin dependent diabetes (IDD) and different types of manifest disease. Among I degree healthy relatives of probands with IDD antibodies were detected in 16%. In disorder of the oral GTT (a small group) ICSA were found in 57% of examinees. In the group of IDD patients which was heterogeneous in duration of disease and age at its onset, the frequency of ICSA was 38%. The least frequency (10%) of antibodies was observed in patients with non-insulin dependent (NIDD) compensated by a diet and oral hypoglycaemic drugs. Among non-compensated NIDD patients 62% were ICSA-positive. Thus, ICSA determined by the enzyme-linked immunosorbent assay, could be employed as a marker of autoimmune damage of the insular apparatus for prognosis of the development of "primary" and "secondary" insulin dependence.
Kondrat'ev
Iu Iu
IuIu
Sadovnikova
N V
NV
Kuraeva
T L
TL
Shcherbacheva
L N
LN
Smirnova
O M
OM
D000954:Antigens, Surface / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D003920:Diabetes Mellitus / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007124:Immunoenzyme Techniques; D007515:Islets of Langerhans / Q000276:immunology*; D011236:Prediabetic State / Q000276:immunology
D000954:Antigens, Surface; D001323:Autoantibodies; D007004:Hypoglycemic Agents
Immunofermentnoe vyiavlenie autoantitel k poverkhnosti ostrovkovykh kletok podzheludochnoĭ zhelezy pri sakharnom diabete i pri povyshennom riske ego razvitiia.