[Modifying action of drug preparations on the effect of promutagen compounds].
The Ames test has shown that the action of nitrosomorpholine and cyclophosphane promutagens on bacteria of Salmonella typhimurium TA 1950 increases while using S-9 liver fraction of rats treated with pharmaceuticals of amidopyrine, reserpine and pyrazidol and decreases while using those treated with phenazepam.
Oblapenko
N G
NG
Fonshteĭn
L M
LM
D000632:Aminopyrine / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology; D002227:Carbazoles / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism / Q000494:pharmacology*; D009602:Nitrosamines / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000187:drug effects
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D002227:Carbazoles; D009153:Mutagens; D009602:Nitrosamines; D000632:Aminopyrine; D001569:Benzodiazepines; C017928:phenazepam; C002741:N-nitrosomorpholine; D012110:Reserpine; D003520:Cyclophosphamide; C009830:pirlindole; D010634:Phenobarbital
Izuchenie modifitsiruiushchego deĭstviia nekotorykh lekarstvennykh preparatov na éffekt soedineniĭ-promutagenov.