Paldimycins A and B and antibiotics 273a2 alpha and 273a2 beta. Synthesis and characterization.
Paldimycin (antibiotic 273a1) and antibiotic 273a2 as well as their individual components, paldimycins A (273a1 alpha) and B (273a1 beta) and antibiotics 273a2 alpha and 273a2 beta were synthesized from paulomycin, paulomycin A and paulomycin B, respectively, by reacting with N-acetyl-L-cysteine. The semisynthetic antibiotics had chromatographic behavior (TLC, HPLC) and physical and chemical properties identical to the properties of the corresponding antibiotics produced by Streptomyces paulus.
Argoudelis
A D
AD
Baczynskyj
L
L
Mizsak
S A
SA
Shilliday
F B
FB
Spinelli
P A
PA
DeZwaan
J
J
D000111:Acetylcysteine / Q000031:analogs & derivatives; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D004187:Disaccharides; D006020:Glycopeptides / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D013053:Spectrophotometry; D013211:Staphylococcus aureus / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D004187:Disaccharides; D006020:Glycopeptides; D007202:Indicators and Reagents; C052531:paldimycin B; C052530:paldimycin A; D000111:Acetylcysteine