[Cyclosporin A in immunosuppressive therapy of kidney transplants (clinical results in 55 patients)].
The authors report the results of a clinical study of the use of cyclosporin A plus low-dose steroids in a consecutive series of 55 kidney transplants with follow-up ranging from 6 to 20 months. The clinical results (rejects, immunosuppressant side effects, 12-month survival of transplant and patient) are compared with those of a similar group of patients on "traditional" therapy (azathioprine plus high-dose steroids). The results of the study confirm the efficacy of cyclosporin A in preventing and controlling acute reject crises in the course of allogenic transplant, though many of the problematic issues related its clinico-therapeutic management remain open questions.
Dean
P
P
Boschiero
L
L
Prati
G F
GF
Recchia
G
G
Faccincani
L
L
Turolla
P J
PJ
Firpo
M
M
D003524:Cyclosporins / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006084:Graft Rejection; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D011379:Prognosis; D013256:Steroids / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors
D003524:Cyclosporins; D013256:Steroids
La ciclosporina A nella terapia immunosoppressiva del trapianto di rene (risultati clinici su 55 pazienti).