Effect of yohimbine on xylazine-induced hypoinsulinemia and hyperglycemia in mares.
Serum insulin and plasma glucose concentrations were determined in 8 mares. Four IV treatments were studied: xylazine (1.1 mg/kg of body weight); yohimbine (0.125 mg/kg); yohimbine (0.125 mg/kg) followed 5 minutes later by xylazine (1.1 mg/kg); and 5 ml of isotonic saline solution as a control. Blood samples were collected before (time 0) and at 5, 15, 30, 60, 120, and 180 minutes after drug administration. Serum insulin concentration decreased and plasma glucose concentration increased in mares given xylazine. Plasma glucose concentration was unchanged in control mares and in mares given yohimbine or yohimbine followed by xylazine. Serum insulin concentration was unchanged in mares given saline solution, but transiently increased in mares given yohimbine alone. Treatment with yohimbine prevented xylazine-induced hypoinsulinemia and hyperglycemia.
Greene
S A
SA
Thurmon
J C
JC
Tranquilli
W J
WJ
Benson
G J
GJ
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D006734:Horse Diseases / Q000139:chemically induced / Q000517:prevention & control*; D006736:Horses; D006943:Hyperglycemia / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary*; D007328:Insulin / Q000097:blood*; D013843:Thiazines / Q000009:adverse effects*; D014991:Xylazine / Q000009:adverse effects*; D015016:Yohimbine / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D013843:Thiazines; D014991:Xylazine; D015016:Yohimbine