Assessment of potential therapies for acute T-2 toxicosis in the rat.
The efficacy of a variety of approaches for the treatment of animals with acute T-2 toxicosis was assessed utilizing young female rats. A single large dose of the water soluble salt of methylprednisolone significantly prolonged survival times in T-2 toxin treated animals. The use of diltiazem hydrochloride, dazemgrel, N-acetylcysteine, dimethyl sulfoxide, adenosine triphosphate (ATP), ATP combined with magnesium chloride, ascorbic acid, and aprotinin did not prolong survival times at the dosages administered. Trichodermin, a trichothecene similar in structure and biochemical activity to T-2 toxin but much less acutely toxic, had a detrimental effect on survival times whether given 1 hr prior to or after T-2 toxin.
Poppenga
R H
RH
Beasley
V R
VR
Buck
W B
WB
D000255:Adenosine Triphosphate / Q000627:therapeutic use; D000818:Animals; D004110:Diltiazem / Q000627:therapeutic use; D008776:Methylprednisolone Hemisuccinate / Q000627:therapeutic use; D009145:Mushroom Poisoning / Q000628:therapy*; D051381:Rats; D012717:Sesquiterpenes / Q000037:antagonists & inhibitors*; D013605:T-2 Toxin / Q000037:antagonists & inhibitors*; D014243:Trichodermin / Q000627:therapeutic use
D012717:Sesquiterpenes; D014243:Trichodermin; D008776:Methylprednisolone Hemisuccinate; D000255:Adenosine Triphosphate; D004110:Diltiazem; D013605:T-2 Toxin