Effect of orally administered aromatic retinoid on murine Langerhans cells.
The effect of orally administered aromatic retinoid (Ro 10-9359) on murine epidermal Langerhans cells (LC) was studied in vivo and in vitro. Daily administration of retinoid caused a transient increase in LC density, as determined by staining for Ia antigens, during the first few days of treatment and thereafter a continuing decrease that reached a maximum at 2 weeks. In addition, the morphology and location in the epidermis had been altered. When the treatment was continued to 4 weeks, the density of LC returned to normal. The Ia-antigen-presenting function of epidermal cells to an allo-Ia-reactive cloned T cell line was elevated at all stages of retinoid treatment examined. This elevation did not correlate with the density of histochemically stainable Ia+ LC. These findings suggest that orally administered retinoid profoundly alters the functional capacity of Ia+ LC.
Shiohara
T
T
Kobayashi
M
M
Narimatsu
H
H
Nagashima
M
M
D000284:Administration, Oral; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D003584:Cytological Techniques; D000078404:Epidermal Cells; D004817:Epidermis / Q000276:immunology; D005050:Etretinate / Q000494:pharmacology*; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007801:Langerhans Cells / Q000187:drug effects* / Q000648:ultrastructure; D051379:Mice; D008809:Mice, Inbred C3H; D012176:Retinoids / Q000494:pharmacology*
D000949:Histocompatibility Antigens Class II; D012176:Retinoids; D005050:Etretinate