title: Synchronous respiration: which ventilator rate is best?
abstract: Twenty-four infants were ventilated through a series of rates (30, 60 and 120/min), to determine which rate was most successful in provoking synchronous respiration. Their spontaneous respiratory rate was also documented during a temporary disconnection from the ventilator: respiratory rate and gestational age were significantly correlated (r = -0.85). Seventeen infants showed synchronous respiration at a ventilator rate of 120/min and 4 at 60/min. Of the remaining 3 infants, 2 only showed synchrony if ventilated at their own spontaneous respiratory frequency (between 60-75/min) and 1 infant was asynchronous at all rates including her own spontaneous respiratory frequency. The 17 infants synchronous at a ventilator rate of 120/min were significantly less mature (p less than 0.01) and had a faster spontaneous respiratory rate (p less than 0.01) than the 6 infants synchronous at ventilator rates of 60-75/min.
authors.affiliation: Department of Child Health, King's College Hospital, London, United Kingdom.
authors.forename: A
authors.initials: A
authors.lastname: Greenough
authors.forename: F
authors.initials: F
authors.lastname: Greenall
authors.forename: H
authors.initials: H
authors.lastname: Gamsu
mesh_terms: D000403:Airway Resistance; D006801:Humans; D007231:Infant, Newborn; D007385:Intermittent Positive-Pressure Ventilation / Q000009:adverse effects; D010366:Peak Expiratory Flow Rate; D011175:Positive-Pressure Respiration / Q000009:adverse effects; D012119:Respiration; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology / Q000628:therapy*