title: Genetic activity of trimethoprim in the Salmonella/microsomal screening system.
abstract: Trimethoprim, a widely used antibacterial drug was tested for its mutagenic potential in the Ames Salmonella/microsomal test system. The results indicated that, when used in the recommended dose range, the drug produced a several-fold increase in the reversion mutations on his(-)----his+ marker in some of the tester strains, compared with the spontaneous reversions. Dose-dependent curves were also obtained for reversion mutations caused by the drug. Ethyl methanesulfonate and benzo[alpha]pyrene were used a control mutagens.
authors.forename: S A
authors.initials: SA
authors.lastname: Rasool
authors.forename: M A
authors.initials: MA
authors.lastname: Khan
authors.forename: A Z
authors.initials: AZ
authors.lastname: Alvi
authors.forename: M N
authors.initials: MN
authors.lastname: Umer
mesh_terms: D000818:Animals; D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D014295:Trimethoprim / Q000633:toxicity*
chemical_list: D009153:Mutagens; D014295:Trimethoprim