[Changes in the total proteolytic activity and inhibitory potential of tumor and lung tissue in mice during growth and metastatic spread of malignant neoplasms].
In tumour tissue and in lungs of mice with carcinoma 3LL, melanoma B-16, adenocarcinoma 755 different changes of proteolytic and antitryptic activities have been revealed. An excessive level of the protease activity and/or a decrease of the inhibitory potential activity are the factors of decompensation of the body's protease-inhibitory system and stimulate development of metastatic process.
Veksler
I G
IG
Veremeenko
K N
KN
Riabukha
V N
VN
Pogorelaia
N F
NF
Khaniuchenko
S I
SI
D000818:Animals; D005260:Female; D008168:Lung / Q000201:enzymology*; D008175:Lung Neoplasms / Q000201:enzymology / Q000473:pathology / Q000556:secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D009132:Muscles / Q000201:enzymology; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000201:enzymology* / Q000473:pathology; D009928:Organ Specificity; D010447:Peptide Hydrolases / Q000378:metabolism*; D011480:Protease Inhibitors / Q000378:metabolism*; D014018:Tissue Distribution
D011480:Protease Inhibitors; D010447:Peptide Hydrolases
Izmeneniia obshcheĭ proteoliticheskoĭ aktivnosti i ingibitornogo potentsiala tkani opukholeĭ i legkikh u mysheĭ v protsesse rosta i metastazirovaniia zlokachestvennykh novoobrazovaniĭ.