title: [Effect of respiratory and circulatory hypoxia on the insulin-producing function of the pancreas and on insulin transport and utilization in tissue in congenital heart defects].
abstract: Radioimmunoassays of plasma C-peptide, and plasma and erythrocyte insulin were made in mixed venous-arterial blood specimens of normal children and those with congenital heart diseases. In all cases, insulin level was higher in erythrocytes, as compared to plasma specimens, obviously due to active insulin deposition by erythrocytes. Venous-arterial difference in insulin may be indicative of tissue insulin uptake. Respiratory and circulatory hypoxia is associated with decreased erythrocyte capacity for insulin deposition and tissue insulin uptake. It is suggested that plasma C-peptide content may be an indicator of pancreatic function.
authors.forename: A A
authors.initials: AA
authors.lastname: Tsyganiĭ
authors.forename: B N
authors.initials: BN
authors.lastname: Gumeniuk
mesh_terms: D001692:Biological Transport; D002096:C-Peptide / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000378:metabolism; D006330:Heart Defects, Congenital / Q000503:physiopathology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D000860:Hypoxia / Q000503:physiopathology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D010179:Pancreas / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D002096:C-Peptide; D007328:Insulin; D006854:Hydrocortisone
vernacular_title: Vliianie dykhatel'noĭ i tsirkuliatornoĭ gipoksii na insulinprodutsiruiushchuiu funktsiiu podzheludochnoĭ zhelezy, transport i utilizatsiiu insulina v tkaniakh pri vrozhdennykh porokakh sertdsa.