title: Priming reduces the bone marrow toxicity of carboplatin.
abstract: A dose of 170 mg/kg of carboplatin is lethal in mice, death occurring through bone marrow failure. This lethality can be avoided by giving the animals 200 mg/kg cyclophosphamide 1 or 2 days before this dose of carboplatin. The improved normal tissue tolerance cannot be explained by altered pharmacokinetics of carboplatin. Increased survival appears to be associated with a more rapid regeneration of the haemopoietic stem cells. Tumour tissue is not protected in the same way and thus a therapeutic gain can be achieved using this protocol.
authors.forename: M E
authors.initials: ME
authors.lastname: Gore
authors.forename: C A
authors.initials: CA
authors.lastname: Hills
authors.forename: Z H
authors.initials: ZH
authors.lastname: Siddik
authors.forename: J P
authors.initials: JP
authors.lastname: Sloane
authors.forename: A R
authors.initials: AR
authors.lastname: Winkley
authors.forename: I E
authors.initials: IE
authors.lastname: Smith
authors.forename: J L
authors.initials: JL
authors.lastname: Millar
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000633:toxicity*; D001835:Body Weight; D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism; D016190:Carboplatin; D002470:Cell Survival / Q000187:drug effects; D003114:Colony-Forming Units Assay; D003520:Cyclophosphamide / Q000494:pharmacology*; D007958:Leukocyte Count / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D009944:Organoplatinum Compounds / Q000378:metabolism / Q000633:toxicity*; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D003520:Cyclophosphamide; D016190:Carboplatin