title: Comparison of mackerel-oil and lard-fat enriched diets on plasma lipids, cardiac membrane phospholipids, cardiovascular performance, and morphology in young pigs.
abstract: Purified mackerel-oil extract or lard fat (9.1% wt/wt) was added to a basal diet of young pigs for 8 wk. Effects on plasma lipids, glucose and insulin, cardiac membrane phospholipids, cardiovascular performance, and morphology were studied. A time-dependent reduction of plasma triglyceride (62%), total cholesterol (41%), and HDL cholesterol (47%) was found in the mackerel-oil-fed pigs. The postprandial glucose and insulin response may indicate a mackerel-oil-induced resistance of insulin receptors. Although the polyunsaturated fatty acid composition of cardiac sarcolemma widely differed between the two groups, all determined indices of heart function were equal. It is concluded that consumption of a fish-oil diet with a low content of monoenes and supplemented with antioxidants reduces plasma lipid levels without producing pathological side effects.
authors.forename: J M
authors.initials: JM
authors.lastname: Hartog
authors.forename: J M
authors.initials: JM
authors.lastname: Lamers
authors.forename: A
authors.initials: A
authors.lastname: Montfoort
authors.forename: A E
authors.initials: AE
authors.lastname: Becker
authors.forename: M
authors.initials: M
authors.lastname: Klompe
authors.forename: H
authors.initials: H
authors.lastname: Morse
authors.forename: F J
authors.initials: FJ
authors.lastname: ten Cate
authors.forename: L
authors.initials: L
authors.lastname: van der Werf
authors.forename: W C
authors.initials: WC
authors.lastname: Hülsmann
authors.forename: P G
authors.initials: PG
authors.lastname: Hugenholtz
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage* / Q000494:pharmacology; D006439:Hemodynamics; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D012508:Sarcolemma / Q000378:metabolism; D012643:Selenium / Q000008:administration & dosage; D013552:Swine / Q000254:growth & development*; D014810:Vitamin E / Q000008:administration & dosage
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D005395:Fish Oils; D007328:Insulin; D008055:Lipids; D008563:Membrane Lipids; D010743:Phospholipids; D014810:Vitamin E; D012643:Selenium