2-(N-nitroso-N-methylamino)propiophenone, a direct acting bacterial mutagen found in nitrosated Ephedra altissima tea.
A new N-nitroso compound identified in a nitrosated tea extract made from the plant Ephedra altissima and shown to be formed under in vivo conditions was identified as 2-(N-nitroso-N-methylamino)propiophenone (NMAP). N-Nitrosoephedrine (NEP), another N-nitroso compound detected in nitrosated Ephedra altissima tea and NMAP are shown to exert mutagenic activity in the Salmonella/mammalian microsome mutagenicity (Ames) test. Base-pair substitution mutation-detecting strains (TA100 and TA1535) showed both compounds to be weak direct-acting mutagens without the addition of S9-mix. The identification, synthesis and mutagenicity of NMAP are discussed.
Tricker
A R
AR
Wacker
C D
CD
Preussmann
R
R
D009152:Mutagenicity Tests; D009153:Mutagens / Q000302:isolation & purification / Q000633:toxicity*; D009602:Nitrosamines / Q000138:chemical synthesis / Q000302:isolation & purification / Q000633:toxicity*; D010936:Plant Extracts / Q000302:isolation & purification / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects*
D009153:Mutagens; D009602:Nitrosamines; D010936:Plant Extracts; C052682:2-(N-nitroso-N-methylamino)propiophenone; C017918:N-nitrosoephedrine