Glutathione and peroxide metabolism in malaria-parasitized erythrocytes.
The glutathione metabolism of Plasmodium falciparum, P. vinckei and P. berghei has been investigated. Human erythrocytes with low glutathione reductase and synthetase activity are still capable of harbouring P. falciparum. Both enzymes have been demonstrated in Plasmodium spp. Moreover, evidence is given for a selenium-independent glutathione peroxidase in malaria parasites.
Fritsch
B
B
Physiologisch-chemisches Institut der Universität, Tübingen, Federal Republic of Germany.
Dieckmann
A
A
Menz
B
B
Hempelmann
E
E
Fritsch
K G
KG
Fritsch
G
G
Jung
A
A
D000818:Animals; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism / Q000469:parasitology*; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005981:Glutathione Synthase / Q000378:metabolism; D006801:Humans; D051379:Mice; D010084:Oxidation-Reduction; D010545:Peroxides / Q000378:metabolism*; D010961:Plasmodium / Q000201:enzymology / Q000378:metabolism*; D010962:Plasmodium berghei / Q000201:enzymology / Q000378:metabolism; D010963:Plasmodium falciparum / Q000201:enzymology / Q000378:metabolism; D012643:Selenium / Q000097:blood; D013379:Substrate Specificity
D010545:Peroxides; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005981:Glutathione Synthase; D005978:Glutathione; D012643:Selenium