Mouse glandular kallikrein genes: identification and characterization of the genes encoding the epidermal growth factor binding proteins.
Previously, three proteins have been separately identified as the mouse epidermal growth factor binding protein (EGF-BP). We have identified and sequenced the coding regions of three distinct genes encoding these EGF-BPs from the BALB/c strain. The genes are all members of the glandular kallikrein gene family, which encodes a highly homologous group of serine proteases. Expression of the EGF-BP genes was detected in mouse salivary gland only and was at a relatively similar level for each gene. The isolation of three distinct genes from the one mouse strain indicates that the conflicting data previously reported in the literature are not a result of allelic polymorphisms or strain differences.
Drinkwater
C C
CC
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
Evans
B A
BA
Richards
R I
RI
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D010450:Endopeptidases / Q000235:genetics*; D005796:Genes; D007610:Kallikreins / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis; D012469:Salivary Glands / Q000378:metabolism*; D020840:Tissue Kallikreins
D009838:Oligodeoxyribonucleotides; D010450:Endopeptidases; D007610:Kallikreins; C489120:Klk13 protein, mouse; D020840:Tissue Kallikreins; C489121:Klk1b22 protein, mouse; C489119:Klk9 protein, mouse; C053223:epidermal growth factor binding protein, mouse