title: Prospective clinical study of Hydron, a synthetic dressing, in delivery of an antimicrobial drug to second-degree burns.
abstract: This clinical trial prospectively evaluates the potential beneficial effects of antimicrobial drug delivery from a synthetic dressing (Hydron-AgSD) formed on second-degree burn wounds. A paste composed of polyethylene glycol-400, poly 2-OH ethylmethacrylate, and silver sulfadiazine (AgSD 1%-3%) matured within one hour to form a solid dressing. In 27 patients, comparable areas of second-degree wounds on the same patient were selected at random for test and control (silver sulfadiazine 1% only) sites. The mean total time of the synthetic dressing application per patient was about nine days, and each dressing remained in place for nearly four days. During this interval the control sites required four dressings changes. In 17 tests for infections, the control areas were contaminated but no bacteria were detected under the synthetic dressing; in three tests, the controls had no bacteria, whereas the synthetic dressing did. Healing of burns was similar under both types of dressing. Benefits of Hydron treatment included increased patient comfort because of the reduced number of dressing changes and, in some cases, greater freedom from contaminating bacteria.
authors.forename: C H
authors.initials: CH
authors.lastname: Fang
authors.forename: P
authors.initials: P
authors.lastname: Nathan
authors.forename: E C
authors.initials: EC
authors.lastname: Robb
authors.forename: J W
authors.initials: JW
authors.lastname: Alexander
authors.forename: B G
authors.initials: BG
authors.lastname: MacMillan
mesh_terms: D000293:Adolescent; D000328:Adult; D001458:Bandages; D002056:Burns / Q000628:therapy*; D002648:Child; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D006801:Humans; D008768:Methylmethacrylates / Q000008:administration & dosage; D011092:Polyethylene Glycols / Q000008:administration & dosage; D011446:Prospective Studies; D011897:Random Allocation; D013411:Sulfadiazine / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; D008768:Methylmethacrylates; D013411:Sulfadiazine; D011092:Polyethylene Glycols; C009931:poly(ethylmethacrylate)