Fulminant hepatitis in renal transplant recipients. The role of the delta agent.
In a series of about 300 renal transplant patients followed from 1972 to 1983, 3 cases of fulminant hepatitis were observed in HBs Ag-positive patients. In the liver biopsies of 2/3 of them, the delta antigen was detected by direct immunofluorescence with a specific anti-delta serum. This result demonstrates the responsibility of the delta agent for the development of fulminant hepatitis, and emphasizes the possibility of delta infection in HBs Ag-positive transplant patients with severe hepatitis.
Kharsa
G
G
Degott
C
C
Degos
F
F
Carnot
F
F
Potent
F
F
Kreis
H
H
D000956:Antigens, Viral / Q000032:analysis; D001706:Biopsy; D002467:Cell Nucleus / Q000382:microbiology; D005260:Female; D006508:Hepatitis Antibodies / Q000032:analysis; D006513:Hepatitis B e Antigens / Q000032:analysis; D003699:Hepatitis D / Q000209:etiology* / Q000473:pathology; D003698:Hepatitis Delta Virus / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male
D000956:Antigens, Viral; D006508:Hepatitis Antibodies; D006513:Hepatitis B e Antigens