Trypanocidal activity of the stearylamine-bearing liposome in vitro.
Liposome made of stearylamine and phosphatidylcholine showed the trypanocidal activity in vitro. Cytotoxicity of the liposome against Trypanosoma cruzi appeared to be the strongest in trypomastigotes followed by amastigotes and epimastigotes. Lysis of the human erythrocyte was undetectably low under the conditions that the liposome kills more than 95% of trypomastigotes. The liposome seems to damage the plasma membrane.
Yoshihara
E
E
Tachibana
H
H
Nakae
T
T
D000588:Amines / Q000494:pharmacology*; D008081:Liposomes / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010713:Phosphatidylcholines / Q000494:pharmacology; D014344:Trypanocidal Agents; D014349:Trypanosoma cruzi / Q000187:drug effects*
D000588:Amines; D008081:Liposomes; D010713:Phosphatidylcholines; D014344:Trypanocidal Agents; C009317:stearylamine