title: Swedish multicenter study on prepyloric and gastric ulcer.
abstract: A double-blind, randomized, multicenter study was performed to compare the effects of sucralfate and cimetidine for the short-term treatment of gastric and prepyloric ulcers. Ulcer healing was evaluated endoscopically at 4-week intervals up to 8 weeks in the PPU study and up to 12 weeks in the GU study. A total of 142 PPU and 134 GU patients completed the study. The overall healing rates after 8 weeks in the PPU study were 83% for the sucralfate group and 90% for the cimetidine group (NS), while the cumulative healing rates after 12 weeks in the GU study were 98% for the sucralfate group and 94% for the cimetidine group (NS). The confidence interval means that the 95% confidence limit ranges from 11% in favour of sucralfate to 2% in favour of cimetidine in the GU study and corresponding figures of 4% 19% in the PPU study. There were significantly more patients in the cimetidine group taking antacid tablets after 3 weeks in the GU study. Symptomatic relief did not differ significantly. Reported side effects and symptoms, pooled together with our duodenal ulcer study, were mostly non-specific and in some part related to the ulcer disease. In conclusion, sucralfate and cimetidine are both excellent healing agents for the short-term treatment of PPU and GU. Both give rapid and good symptomatic relief with no side effects of any importance.
authors.forename: I
authors.initials: I
authors.lastname: Kagevi
authors.forename: O
authors.initials: O
authors.lastname: Anker-Hansen
authors.forename: L
authors.initials: L
authors.lastname: Carling
authors.forename: H
authors.initials: H
authors.lastname: Glise
authors.forename: B
authors.initials: B
authors.lastname: Hallerbäck
authors.forename: J H
authors.initials: JH
authors.lastname: Solhaug
authors.forename: L E
authors.initials: LE
authors.lastname: Svedberg
authors.forename: L
authors.initials: L
authors.lastname: Wählby
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000863:Antacids / Q000008:administration & dosage; D002927:Cimetidine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013276:Stomach Ulcer / Q000188:drug therapy*; D013392:Sucralfate / Q000627:therapeutic use*; D013548:Sweden
chemical_list: D000863:Antacids; D013392:Sucralfate; D002927:Cimetidine