title: Renal reflexes in the regulation of blood pressure and sodium excretion.
abstract: The rich innervation of the kidney is distributed to all structures of renal parenchyma thus providing important anatomical support to the functional evidence that the renal nerves can control kidney functions and send signals on the kidney environment to the central nervous system. Efferent renal nerve fibres are known to influence renal haemodynamics by modifying arteriolar vascular tone, renin release by a direct action on juxtaglomerular cells, and the excretion of sodium and water by changing tubular reabsorption of sodium and water at the different tubular levels. Mechano- and chemo-receptors have been shown in the kidney. Afferent fibres connected with renal receptors convey signals to the central nervous system both at spinal and supraspinal levels. The central areas receiving inputs from the kidney are those involved in the control of cardiovascular homeostasis and fluid balance. Activation of renal receptors by the electrical stimulation of renal afferent fibres were found to elicit both excitatory and inhibitory sympathetic responses. Although the existence of excitatory renorenal reflexes has been suggested, electrophysiological and functional data demonstrate that neural renorenal reflexes exert a tonic inhibitory influence on the tubular sodium and water reabsorption and on the secretion of renin from the juxtaglomerular cells.
authors.affiliation: Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Stella
authors.forename: R
authors.initials: R
authors.lastname: Golin
authors.forename: S
authors.initials: S
authors.lastname: Genovesi
authors.forename: A
authors.initials: A
authors.lastname: Zanchetti
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001794:Blood Pressure; D006339:Heart Rate; D006801:Humans; D007668:Kidney / Q000294:innervation* / Q000502:physiology; D012018:Reflex; D012964:Sodium / Q000652:urine*
chemical_list: D012964:Sodium