The influence of irradiation on the biological half-life of prostacyclin in plasma of patients with gastrointestinal cancer.
In seven patients suffering from inoperable pancreatic cancer and in 14 patients with inoperable colonic cancer the half-life (T/2) of prostaglandin (PG)I2 in plasma in vitro has been determined before and at various intervals after irradiation. No significant difference of PGI2-T/2 could be observed either before irradiation, at the end of the irradiation period or 3 and 6 weeks after the last irradiation. Thus irradiation does not appear to interfere with the degradation of PGI2-T/2 in plasma. In patients with inoperable pancreatic and colonic cancer the PGI2-T/2 was not significantly different to that of the PGI2-T/2 of controls. Thus, a shortening of PGI2-T/2 is not a common feature in tumour patients. Hyperaggregation promoting seeding of metastases is not influenced by irradiation via the particular parameter of the PG-system.
Polterauer
P
P
Second Department of Gastroenterology and Hepatology, University of Vienna, Austria.
Sinzinger
H
H
Peskar
B A
BA
D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000097:blood* / Q000532:radiotherapy; D011464:Epoprostenol / Q000097:blood*; D005260:Female; D005720:Gamma Rays; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000532:radiotherapy; D011830:Radiation Effects; D013997:Time Factors
D011464:Epoprostenol