CALLA-negative, TdT- and CD7-positive acute lymphoblastic leukemia: a phenotype associated with poor prognosis.
Eight ALL patients displaying a CD7+, Tdt+, CD10-, T MoAbs-, myeloid MoAbs-, AP+ phenotype are described. Some patients showed well-known risk factors such as cytogenetic abnormalities, high WBC count, mediastinal mass, and/or organomegalies. The clinical behaviour was very poor and only one patient is in CR and off therapy. Therefore such a pre-T phenotype, although sometimes associated with the other risk factors, could be considered a poor prognosis phenotype.
De Rossi
G
G
Hematology Section of the Department of Human Biopathology, University La Sapienza, Rome, Italy.
Aloe Spiriti
M A
MA
Cafolla
A
A
Gastaldi
R
R
Lo Coco
F
F
Lopez
M
M
Luciani
M
M
Pasqualetti
D
D
Testi
A M
AM
Mandelli
F
F
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D002648:Child; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D008297:Male; D010641:Phenotype; D011379:Prognosis; D012307:Risk Factors; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal