title: Platelet reactions after interaction with cultured Plasmodium falciparum infected erythrocytes.
abstract: An in vitro model for studying the interaction between normal human platelets and Plasmodium falciparum infected erythrocytes in culture is described. After the interaction, changes in platelet function such as enhanced aggregation response to exogenous ADP and increased secretion of dense granule contents were reproduced. Some of these responses represented manifestations of platelet hypersensitivity described earlier in acute malaria infections in man and mice. Preliminary investigations of the mechanisms involved in such reactions revealed that ADP and thromboxane A2 mechanisms contributed about 79% and 18.5% of the enhanced aggregation response to exogenous stimuli in the system.
authors.forename: A L
authors.initials: AL
authors.lastname: Inyang
authors.forename: O
authors.initials: O
authors.lastname: Sodeinde
authors.forename: D T
authors.initials: DT
authors.lastname: Okpako
authors.forename: E M
authors.initials: EM
authors.lastname: Essien
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000502:physiology*; D002478:Cells, Cultured; D004912:Erythrocytes / Q000469:parasitology*; D006801:Humans; D008288:Malaria / Q000097:blood*; D010963:Plasmodium falciparum; D010974:Platelet Aggregation / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors
chemical_list: D012701:Serotonin; D000244:Adenosine Diphosphate; D013930:Thromboxane-A Synthase