Tissue reactions to wear products from polyacetal (Delrin) and UHMW polyethylene in total hip replacement.
The tissue reaction to implanted materials and their wear products is important for the long-term fixation of a total hip replacement (THR). Recent reports indicate a relatively high incidence of aseptic loosening with Christiansen total hip prostheses. We examined tissue reactions to wear products in two groups of prostheses: 16 Christiansen prostheses with polyacetal (Delrin) sockets, and 18 Charnley-Müller total hip prostheses with ultrahigh-molecular-weight polyethylene (UHMWP) sockets. Specimens from these 34 patients were compared in a combined qualitative and semiquantitative morphological study. We saw similar histological changes in specimens of both groups, but specimens from the bone-cement interfaces of the acetabulum and femur shaft in the polyacetal group showed more inflammation and necrosis.
Mathiesen
E B
EB
Lindgren
J U
JU
Reinholt
F P
FP
Sudmann
E
E
D000080:Acetals; D000368:Aged; D001672:Biocompatible Materials; D003238:Connective Tissue / Q000473:pathology; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology* / Q000473:pathology; D006621:Hip Joint / Q000473:pathology; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009336:Necrosis; D011095:Polyethylenes / Q000009:adverse effects*; D011108:Polymers; D011475:Prosthesis Failure
D000080:Acetals; D001672:Biocompatible Materials; D011095:Polyethylenes; D011108:Polymers; C016067:polyacetal