The effect of indomethacin on the response of protein synthesis to feeding in rats and man.
Protein synthesis was measured in muscle of fed and fasted rats. Synthesis rates were 29% higher with feeding. Treatment with indomethacin before feeding completely blocked the stimulation of protein synthesis. Whole-body protein synthesis was measured in six healthy volunteers with [15N]glycine in fasted and fed states. Feeding increased synthesis rates by 50%. An oral dose of indomethacin 2 h before the measurement of protein synthesis had no effect in either the fasted or fed state.
McNurlan
M A
MA
McHardy
K C
KC
Broom
J
J
Milne
E
E
Fearns
L M
LM
Reeds
P J
PJ
Garlick
P J
PJ
D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005215:Fasting; D005502:Food; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D009124:Muscle Proteins / Q000096:biosynthesis; D009584:Nitrogen / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D009124:Muscle Proteins; D009584:Nitrogen; D007213:Indomethacin