title: A bolus/basal multiple injection regimen in type I diabetes. A multicentre trial using a new 'fountain-pen' device for short-acting human insulin as well as long-acting human insulin.
abstract: A trial was undertaken to ascertain the effect and acceptability of a multiple insulin injection regimen (MII) in patients with insulin-dependent diabetes mellitus using short-acting monocomponent human soluble insulin (Actrapid HM; Novo) for pre-meal bolus injections with the NovoPen injection device (Novo) and long-acting human insulin (Ultratard HM; Novo) at bedtime. Fifty-four patients, all previously on twice-daily short/intermediate-acting human insulin (Monotard HM; Novo) and Actrapid HM, were randomly selected. There was a significant overall improvement in diabetic control over the 12 weeks of the trial, the glycosylated haemoglobin (Hb A1) dropping from a mean of 9.8 +/- 2.2% to 8.6 +/- 1.7% (P less than 0.05). MII, using the NovoPen, was found to be more convenient than conventional insulin administration by 92% of the subjects. It is concluded that the NovoPen is a useful and convenient means of administering pre-meal boluses in an MII regimen, with a very high rate of acceptance by patients of all ages.
authors.forename: L A
authors.initials: LA
authors.lastname: Distiller
authors.forename: L I
authors.initials: LI
authors.lastname: Robertson
authors.forename: R
authors.initials: R
authors.lastname: Moore
authors.forename: F
authors.initials: F
authors.lastname: Bonnici
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002986:Clinical Trials as Topic; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D005069:Evaluation Studies as Topic; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007267:Injections / Q000295:instrumentation*; D007328:Insulin / Q000008:administration & dosage*; D049528:Insulin, Long-Acting / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013997:Time Factors
chemical_list: D006442:Glycated Hemoglobin; D007328:Insulin; D049528:Insulin, Long-Acting