Distribution of vitamin B12 R binder in normal human tissues: an immunohistochemical study.
We studied the distribution of vitamin B12 R binder in various normal human tissues by use of an immunoperoxidase technique. Positive staining for R binder was observed in almost all glandular epithelia of digestive system, bronchial glands, renal proximal tubules, prostate, uterus, Fallopian tube, mammary gland, and sweat glands. The distribution of R binder was similar to that of lactoferrin and secretory component. These findings support the hypothesis that R binder plays a role in the local defense mechanism.
Kudo
H
H
Ohshio
G
G
Ogawa
K
K
Wakatsuki
Y
Y
Inada
M
M
Hamashima
Y
Y
Miyake
T
T
D004064:Digestive System / Q000378:metabolism; D004702:Endocrine Glands / Q000378:metabolism; D006413:Hematopoietic System / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D009132:Muscles / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D012137:Respiratory System / Q000378:metabolism; D014018:Tissue Distribution; D014155:Transcobalamins / Q000378:metabolism*; D014566:Urogenital System / Q000378:metabolism; D014805:Vitamin B 12 / Q000378:metabolism*
D014155:Transcobalamins; D014805:Vitamin B 12