Polyclonal B-cell activation after intravenous immunoglobulin therapy in idiopathic thrombocytopenic purpura--an anti-idiotype response?
Polyclonal B cell activation occurred in 3 patients following treatment with intravenous immunoglobulin (i.v. Ig) for idiopathic thrombocytopenic purpura (ITP). The possibility that this may represent an anti-idiotype response and the hypothesis that prolonged remission of ITP may be induced by this mechanism are discussed.
Wangel
A G
AG
Department of Medicine, University of Adelaide (Queen Elizabeth Hospital), South Australia.
Lorenzetti
M
M
Pettersson
T
T
D000328:Adult; D000368:Aged; D001402:B-Lymphocytes; D001696:Biomechanical Phenomena; D005260:Female; D006462:Hemolytic Plaque Technique; D006801:Humans; D007116:Immunization, Passive; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D007275:Injections, Intravenous; D008213:Lymphocyte Activation; D011696:Purpura, Thrombocytopenic / Q000628:therapy*
D007130:Immunoglobulin Idiotypes