Reactivity of human trophoblast with an antibody to the HLA class II antigen, HLA-DP.
Cytotrophoblast cells in term amniochorion and in first trimester chorionic villi were shown by immunohistology of frozen tissue sections to bind B7/21, an antibody specific for the MHC Class II antigen, HLA-DP. This binding was shown to be specific, as adsorption of the B7/21 antibody with a B cell line expressing HLA-DP prevented subsequent binding to trophoblast. When tested with a variety of other antibodies reacting with HLA-DR, HLA-DQ or the common sequences of HLA-DR, -DQ and -DP, trophoblast was negative, thus confirming previous reports. The significance of this unique pattern of reactivity of trophoblast is discussed.
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D000911:Antibodies, Monoclonal; D005260:Female; D006681:HLA-D Antigens / Q000302:isolation & purification*; D006682:HLA-DP Antigens / Q000302:isolation & purification*; D006801:Humans; D007124:Immunoenzyme Techniques; D011247:Pregnancy; D014327:Trophoblasts / Q000276:immunology*
D000911:Antibodies, Monoclonal; D006681:HLA-D Antigens; D006682:HLA-DP Antigens