Polycythaemia following renal transplantation: an association with azathioprine dosage?
Patients from a renal transplantation unit with an unusually high incidence of polycythaemia were divided into polycythaemic and control groups. The rate of rise of haemoglobin concentration was not significantly different in the two groups. The polycythaemic group received a significantly lower dose of azathioprine (p less than 0.005) and included more patients with polycystic disease than the control group (p less than 0.05). An effect of azathioprine on bone marrow function was suggested by the polycythaemic group also having a higher mean white cell count (p less than 0.02). Azathioprine dosage correlated negatively with post-transplantation polycythaemia regardless of the original cause of renal failure.
Webb
D B
DB
Price
K A
KA
Hutton
R D
RD
Newcombe
R G
RG
Salaman
J R
JR
Orchard
J
J
D001379:Azathioprine / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D009560:Niridazole / Q000627:therapeutic use; D007690:Polycystic Kidney Diseases / Q000150:complications; D011086:Polycythemia / Q000139:chemically induced* / Q000209:etiology; D011239:Prednisolone / Q000627:therapeutic use
D011239:Prednisolone; D001379:Azathioprine; D009560:Niridazole