The effect of thymopoietin 32-34 (TP3) on suramin-induced inhibition on delayed type hypersensitivity in guinea pigs.
Suramin administration inhibits virus replication and produces impaired immunoregulation. Delayed type hypersensitivity (DTH)-reaction was inhibited by Suramin (200 mg/kg, i.p.) injection in guinea-pigs immunized with BCG vaccine. Suramin-inhibited DTH-reaction was restored to normal level after 4 days of treatment with thymopoietin 32-34 (TP 3) and TP5 (1 mg/kg, i.p.), TP3 greater than TP5. TP3 produced the strongest restoration when applied together with Suramin, but a single treatment with TP3 or TP5 oligopeptide inhibited the development of DTH-reaction. TP3 with Suramin treatment might be advantageous to eliminate defective side effects of Suramin on immune system and TP3 with indirect inducing action on IL-2, IFN-gamma production may be useful in therapy of AIDS patients.
Dénes
L
L
Chemical Works of Gedeon Richter Ltd., Pharmacological Research Centre, Budapest, Hungary.
Hajós
G
G
Szporny
L
L
Szende
B
B
Lapis
K
K
Sipka
S
S
Szegedi
G
G
D000818:Animals; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007111:Immunity, Cellular / Q000187:drug effects*; D009842:Oligopeptides / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D013498:Suramin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D016305:Thymopentin; D013946:Thymopoietins / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*
D009842:Oligopeptides; D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; C051920:splenotritin; D013498:Suramin; C045802:thymocartin; D016305:Thymopentin