Two alloantigens on human monocytes: a diallelic system?
A positive monocyte crossmatch and therefore anti-monocyte antibodies are negative factors in bone marrow and renal transplantation. When the monocyte antigens themselves can be recognized, matching for the antigens involved here may become a possibility. In order to find useful anti-monocyte sera as typing reagents, human sera were screened against panel cells. Several monocyte specific sera were obtained. These sera recognized two monocyte antigens, HMA-1 and HMA-2. No similarity with any of the HLA antigens was observed. Every individual tested was positive for at least one of these two monocyte antigens, suggesting that HMA-1 and HMA-2 constitute a diallelic system.
Jager
M J
MJ
Claas
F H
FH
D'Amaro
J
J
Baldwin
W M
WM
van Rood
J J
JJ
D005455:Fluorescent Antibody Technique; D005816:Genetic Complementation Test; D006801:Humans; D066298:In Vitro Techniques; D007519:Isoantigens / Q000032:analysis* / Q000235:genetics; D009000:Monocytes / Q000276:immunology*; D010641:Phenotype
D007519:Isoantigens