title: Expression of lymphocyte-associated antigens on neoplastic angioendotheliomatosis.
abstract: Neoplastic angioendotheliomatosis (NAE) is a rare and fatal disorder and has been regarded as a multifocal in situ neoplastic change of endothelial cells. This report describes a case of NAE from whom a biopsy specimen was obtained and studied immunohistologically using several monoclonal antibodies against lymphocyte-associated antigens. The tumor cells occluding luminal space express both T and B cell markers such as Leu-1, Leu-3, Leu-10, Leu-M3, HLA-DR, and HLA-DQ, whereas they do not express Leu-2, Leu-4, lymphocyte-common antigen, and immunoglobulins. Factor VIII as a marker of vascular endothelial cell is false positive in the present case. Since immunoglobulins as a definitive B lymphocyte marker are negative in this case, there is no direct evidence indicating that NAE is a tumor of B lymphocytic lineage as previously reported. These results suggest the two possibilities that NAE is a unique variant of T cell lymphoma or true vascular endothelial tumor sharing the common histogenesis with malignant lymphoma. As it stands the former possibility is more likely than the latter in our case.
authors.affiliation: Department of Pathology, Tokyo Metropolitan Institute of Gerontology, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Maruyama
authors.forename: Y
authors.initials: Y
authors.lastname: Ishida
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Koike
authors.forename: K
authors.initials: K
authors.lastname: Nagao
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D006683:HLA-DQ Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D006390:Hemangioendothelioma / Q000276:immunology*; D006801:Humans; D012878:Skin Neoplasms / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens