[Decrease in arterial PO2 with captopril administration in secondary pulmonary hypertension and right heart failure].
The ventilation-perfusion match under therapy with captopril was registered in 14 patients with secondary pulmonary hypertension and right heart failure caused by chronic obstructive lung disease. In none of the cases, changes of cranialisation of the perfusion or increasing ventilation-perfusion mismatch was found, but a significant fall in O2 was seen in all patients. This O2-depression is due to decreasing stroke volume of the right to left shunt.
Borkenstein
J
J
Medizinischen Universittsklinik Graz.
D002216:Captopril / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D008173:Lung Diseases, Obstructive / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D011660:Pulmonary Heart Disease / Q000188:drug therapy; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D014692:Ventilation-Perfusion Ratio / Q000187:drug effects
D002216:Captopril; D010100:Oxygen
Abnahme des arteriellen PO2 unter Captoprilgabe bei sekundärer pulmonaler Hypertonie und Rechtsherzschwäche.