Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents.
Lysosomotropic detergents, which kill mammalian cells by disrupting lysosomal membranes, have now been found to be antifungals also. All strains in our assay are susceptible. The mode of action is as yet undetermined, but intracellular vacuoles may be the primary targets.
Firestone
R A
RA
Pisano
J M
JM
Garrity
G M
GM
Fromtling
R A
RA
Zimmerman
S B
SB
D002175:Candida / Q000187:drug effects; D003902:Detergents / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects* / Q000648:ultrastructure; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000494:pharmacology; D007654:Ketoconazole / Q000494:pharmacology; D008247:Lysosomes / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013501:Surface-Active Agents / Q000494:pharmacology*; D014617:Vacuoles / Q000187:drug effects
D003902:Detergents; D007093:Imidazoles; D013501:Surface-Active Agents; C002822:1-dodecylimidazole; D007654:Ketoconazole