title: Cytodiagnosis of a spindle-cell tumor of the breast using antisera to epithelial membrane antigen.
abstract: A case of an unusual breast tumor is described in which the smear from a fine needle aspiration (FNA) biopsy caused difficulty in differentiating between a spindle-cell carcinoma and a sarcoma. The problem was resolved by the immunoperoxidase demonstration of epithelial membrane antigen (EMA) in the cells, thus enabling a definitive diagnosis of spindle-cell carcinoma to be made. This case further demonstrates the utility of demonstrating EMA in FNA specimens to distinguish between epithelial and nonepithelial neoplasms.
authors.forename: R
authors.initials: R
authors.lastname: Gal
authors.forename: S
authors.initials: S
authors.lastname: Gukovsky-Oren
authors.forename: J M
authors.initials: JM
authors.lastname: Lehman
authors.forename: P
authors.initials: P
authors.lastname: Schwartz
authors.forename: E
authors.initials: E
authors.lastname: Kessler
mesh_terms: D000368:Aged; D000906:Antibodies / Q000032:analysis*; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D002277:Carcinoma / Q000175:diagnosis*; D003581:Cytodiagnosis; D003937:Diagnosis, Differential; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008565:Membrane Proteins / Q000276:immunology*; D018396:Mucin-1; D012509:Sarcoma / Q000175:diagnosis; D012698:Serologic Tests
chemical_list: D000906:Antibodies; D008565:Membrane Proteins; D018396:Mucin-1