title: Focal arteriolar insudation. A response of arterioles to chronic nonspecific irritation.
abstract: The subcutaneous insertion of sterile, inert plastic pellets over the cremaster muscles of rats induces characteristic focal lesions of the arterioles at a distance from the pellets. These lesions appear with a delay of about 6 hours; by light microscopy they are characterized by a focal dilatation accompanied by endothelial damage and increased permeability. They are more severe if the pellets are loaded with histamine and are inhibited if the pellets are loaded with serotonin. Electron microscopy shows interendothelial gaps; the media is massively infiltrated with blood components and fibrin. The medial smooth muscle cells are stretched and at times necrotic; inflammatory cells are scarce. On the basis of these features the lesion was named focal arteriolar insudation (FAI). Although its pathogenesis is not yet clear, the data at hand suggest that it is caused by endogenous mediators affecting the smooth muscle cells and/or the endothelium. FAI appears to be a specific arteriolar response to chronic nonspecific irritation.
authors.forename: H F
authors.initials: HF
authors.lastname: Cuénoud
authors.forename: I
authors.initials: I
authors.lastname: Joris
authors.forename: R S
authors.initials: RS
authors.lastname: Langer
authors.forename: G
authors.initials: G
authors.lastname: Majno
mesh_terms: D000818:Animals; D001158:Arteries / Q000473:pathology*; D001160:Arterioles / Q000473:pathology* / Q000503:physiopathology; D002199:Capillary Permeability; D004343:Drug Implants; D005549:Foreign-Body Reaction / Q000473:pathology* / Q000503:physiopathology; D006632:Histamine / Q000633:toxicity*; D008297:Male; D008854:Microscopy, Electron; D010539:Permeability; D051381:Rats; D012018:Reflex; D012701:Serotonin / Q000494:pharmacology; D013997:Time Factors; D014699:Venules / Q000473:pathology
chemical_list: D004343:Drug Implants; D012701:Serotonin; D006632:Histamine