Antidepressants for cancer pain and other painful syndromes with deafferentation component: comparison of amitriptyline and trazodone.
The Authors report a clinical multicentre experience with antidepressant agents (trazodone and amitriptyline) in the treatment of chronic cancer pain with deafferentation component. Forty-five patients were admitted to the study: 27 with oncological peripheral nerve lesions, 6 with post herpetic neuralgias, 10 with not oncological nerve lesions, 2 with central nervous lesions. Almost all of them were already being treated with NSAID associated with weak or strong opioids. A random double blind study was performed: 23 patients were treated with trazodone, 22 with amitriptyline. In the assessment of results, pain intensity, hours of sleep, hours standing and lying, side effects, mood, anxiety, weakness were all taken into consideration. The therapeutic analgesic efficacy of the two drugs proved to be similar.
Ventafridda
V
V
Divisione di terapia del dolore e cure palliative, Istituto Nazionale dei Tumori, Milano.
Bonezzi
C
C
Caraceni
A
A
De Conno
F
F
Guarise
G
G
Ramella
G
G
Saita
L
L
Silvani
V
V
Tamburini
M
M
Toscani
F
F
D000328:Adult; D000368:Aged; D000639:Amitriptyline / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000503:physiopathology*; D009437:Neuralgia / Q000188:drug therapy*; D010292:Paresthesia / Q000188:drug therapy*; D011897:Random Allocation; D014196:Trazodone / Q000009:adverse effects / Q000627:therapeutic use*
D000639:Amitriptyline; D014196:Trazodone