[Effect of benzydamine on release of prostaglandin E2 and prostacyclin from rabbit gastric mucosa cells].
The effect of the antiinflammatory drug benzydamine (Tantum) on prostaglandin E2 (PGE2) release from rabbit gastric mucosal cells was investigated. Up to 1 mmol/l benzydamine had no significant effect on PGE2 and prostacyclin (PGI2) formation and release. The lack of interference with gastric mucosal prostaglandin synthesis might explain the non-ulcerogenicity of this compound compared to other non-steroidal antiinflammatory drugs (e.g. indomethacin).
Hell
M
M
Bauer
A C
AC
Sewing
K F
KF
D000818:Animals; D001591:Benzydamine / Q000494:pharmacology*; D015232:Dinoprostone; D011464:Epoprostenol / Q000378:metabolism*; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011458:Prostaglandins E / Q000378:metabolism*; D011720:Pyrazoles / Q000494:pharmacology*; D011817:Rabbits
D011458:Prostaglandins E; D011720:Pyrazoles; D001591:Benzydamine; D011464:Epoprostenol; D015232:Dinoprostone
Einfluss von Benzydamin auf die Freisetzung von Prostaglandin E2 und Prostazyklin aus Magenschleimhautzellen des Kaninchens.