[Delayed development of chimerism following T-cell depleted bone marrow transplantation].
Comparison of cytogenetic chimaerism was performed in two children after bone marrow transplantation (bmt) with resp. without T-cell depletion for ANLL. It showed a marked delay of full bone marrow function in the patient with a T-depleted graft. Host type bone marrow cells persisted over many months, whereas they disappeared quickly when undepleted marrow was transplanted. Donor-T-cells apparently interact with remaining host cells and thus they might more efficiently eliminate leukaemia. Therefore total removal of T-cells from the graft seems risky in bmt for leukaemia.
Walther
J U
JU
Bender-Götze
C
C
Haas
R
R
Rieber
E
E
D016026:Bone Marrow Transplantation; D002648:Child; D002678:Chimera; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000628:therapy*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
Verzögerte Chimärismusentwicklung nach T-Zell-depletierter Knochenmark-transplantation.