One-dose beclomethasone dipropionate aerosol in the treatment of seasonal allergic rhinitis. A preliminary report.
Forty-one patients were treated during the birch pollen season for three weeks in a randomized, double-blind placebo controlled preliminary study. Ten patients were treated with beclomethasone dipropionate aerosol 400 micrograms once daily, 10 patients with placebo once daily, 10 patients with 400 micrograms beclomethasone dipropionate in the morning and placebo in the evening and 11 patients with 200 micrograms beclomethasone twice daily. The severity of the nasal symptoms was compared before the trial, during the pollen season without treatment, at the time of peak pollen counts and at the end of the treatment. Symptoms were equally controlled by beclomethasone dipropionate 400 micrograms once daily (two puffs of 100 micrograms per nostril), and 200 micrograms twice daily (two puffs of 50 micrograms per nostril twice). All active drug regimens were better than placebo. In conclusion, this study shows that one-dose beclomethasone dipropionate of 400 micrograms is effective in the treatment of seasonal allergic rhinitis.
Nuutinen
J
J
Ruoppi
P
P
Suonpää
J
J
D000328:Adult; D000336:Aerosols; D001507:Beclomethasone / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*
D000336:Aerosols; D001507:Beclomethasone