Preliminary clinical trial of immunotherapy for malignant glioma.
An immunotherapy protocol based on intracranial implantation of stimulated, autologous lymphocytes into the tumor bed following surgical debulking of malignant glioma is described. Phase I clinical trials in human patients are now in progress. Preliminary data representing the first 39 patients treated are presented briefly.
Ingram
M
M
Experimental and Clinical Immunotherapy Laboratory, Huntington Medical Research Institutes, Pasadena, CA 91101.
Shelden
C H
CH
Jacques
S
S
Skillen
R G
RG
Bradley
W G
WG
Techy
G B
GB
Freshwater
D B
DB
Abts
R M
RM
Rand
R W
RW
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000628:therapy*; D002986:Clinical Trials as Topic; D005260:Female; D005910:Glioma / Q000628:therapy*; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D007376:Interleukin-2 / Q000494:pharmacology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D007376:Interleukin-2