Urolithogenesis of mixed foreign body stones.
Urine of male Sprague-Dawley rats was supersaturated for struvite and often contained struvite crystals. Ethylene glycol administration to these rats resulted in elevation of urinary oxalate and calcium oxalate supersaturation, and induced calcium oxalate crystalluria. Implantation of foreign bodies in their urinary bladders and changing their urinary ambient conditions by administering ethylene glycol for two weeks at two week intervals resulted in the formation of urinary stones of mixed composition containing calcium oxalate and struvite. Crystal-onto-crystal epitaxy did not appear to play any role in the development of these stones.
Khan
S R
SR
Department of Pathology, College of Medicine, University of Florida, Gainesville 32610.
Hackett
R L
RL
D000818:Animals; D002129:Calcium Oxalate / Q000652:urine; D003460:Crystallization; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000494:pharmacology; D005547:Foreign Bodies / Q000150:complications*; D005549:Foreign-Body Reaction / Q000209:etiology* / Q000652:urine; D008274:Magnesium / Q000652:urine; D017616:Magnesium Compounds; D008297:Male; D008855:Microscopy, Electron, Scanning; D010710:Phosphates / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D000069877:Struvite; D013997:Time Factors; D001743:Urinary Bladder; D001744:Urinary Bladder Calculi / Q000209:etiology* / Q000652:urine
D005026:Ethylene Glycols; D017616:Magnesium Compounds; D010710:Phosphates; D002129:Calcium Oxalate; D000069877:Struvite; D019855:Ethylene Glycol; D008274:Magnesium