Treatment of nosocomial aspiration pneumonia and soft-tissue infections in diabetic patients.
Nosocomial aspiration pneumonia and infections of soft tissue are most often caused by mixed aerobic and anaerobic pathogens. Single-agent therapy with a beta-lactam antibiotic is tending to replace combination therapy because it is as effective and less toxic. Important considerations in choosing among the beta-lactam antibiotics include a long pharmacologic half-life, permitting less frequent administration, and cost per gram.
Venezio
F R
FR
Loyola University Medical Center, Maywood, Illinois.
D002437:Cefazolin / Q000627:therapeutic use; D002439:Cefotaxime / Q000031:analogs & derivatives / Q000627:therapeutic use; D015296:Ceftizoxime; D003363:Cost Control; D003428:Cross Infection / Q000188:drug therapy*; D048909:Diabetes Complications; D006207:Half-Life; D006801:Humans; D011015:Pneumonia, Aspiration / Q000188:drug therapy* / Q000209:etiology; D012883:Skin Ulcer / Q000209:etiology / Q000628:therapy*
D015296:Ceftizoxime; D002437:Cefazolin; D002439:Cefotaxime