Granulomatous lung disease in children by aspiration of medications.
Post mortem examinations of 8 infants, 11 d to 5 months old and one 12 year old girl, demonstrated foreign bodies in the lungs which could be identified as orally administered drugs: cholestyramine (Questran) and phenobarbital (Luminal, Gardenal) or phenydantin-components. The microscopic changes caused by such deposits and the histologic methods of identifying medicines are presented. The authors point to the role of aspiration in deposit formation and to the pseudomiliary granulomatous nature of subsequent changes. It is proposed to define the alterations as a separate form of aspiratory lesion in children.
Hański
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W
Figurski
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Fermus
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R
D000284:Administration, Oral; D000632:Aminopyrine / Q000009:adverse effects; D002648:Child; D002792:Cholestyramine Resin / Q000009:adverse effects; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D062385:Hydroxybenzoates / Q000009:adverse effects; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000473:pathology; D008297:Male; D009581:Nitrofurans / Q000009:adverse effects; D010634:Phenobarbital / Q000009:adverse effects; D010672:Phenytoin / Q000009:adverse effects; D011015:Pneumonia, Aspiration / Q000139:chemically induced* / Q000473:pathology
D062385:Hydroxybenzoates; D009581:Nitrofurans; D000632:Aminopyrine; D002792:Cholestyramine Resin; D010672:Phenytoin; C013150:nifuroxazide; D010634:Phenobarbital