[Participation of the proteolysis system in promoting the virulence of the influenza virus and development of the infectious process; the antiviral effect of protease inhibitors].
The results of the authors' own studies and data from the literature attesting to an important role of proteolytic mechanisms in influenza virus physiology and the development of the infectious process are summarized. The etiotropic and pathogenetic effectiveness of proteolysis inhibitors in influenza was demonstrated experimentally and clinically. Data are presented on the immunostimulating and prophylactic effect of a proteolysis inhibitor, E-aminocaproic acid. It is concluded that the use of proteolysis inhibitors in viral infections holds good promise.
Lozitskiĭ
V P
VP
Fedchuk
A S
AS
Puzis
L E
LE
Buĭko
V P
VP
Girlia
Iu I
IuI
D000818:Animals; D000998:Antiviral Agents; D006801:Humans; D007251:Influenza, Human / Q000209:etiology* / Q000382:microbiology; D051379:Mice; D009975:Orthomyxoviridae / Q000187:drug effects / Q000201:enzymology / Q000472:pathogenicity*; D010447:Peptide Hydrolases / Q000378:metabolism*; D011480:Protease Inhibitors / Q000627:therapeutic use*; D014774:Virulence / Q000187:drug effects; D014776:Virus Cultivation
D000998:Antiviral Agents; D011480:Protease Inhibitors; D010447:Peptide Hydrolases
Uchastie sistemy proteoliza v realizatsii virulentnosti virusa grippa i razvitii infektsionnogo protsessa; protivovirusnoe deĭstvie ingibitorov proteaz.