[Effects of recombinant human interferon-alpha A/D on the growth of experimental tumors in mice].
The effects of recombinant human interferon-alpha A/D (rIFN-alpha A/D, a subtype of recombinant human leukocyte interferon with biological activities against murine tumor cells) on the growth of murine tumors were studied. rIFN-alpha A/D significantly inhibited the growth of mouse M5076 reticulum cell sarcoma, MOPC-104E myeloma, colon carcinoma 26 and Meth A fibrosarcoma by dose-dependent fashion. rIFN-alpha A/D also inhibited the metastases and growth of Lewis lung carcinoma and showed a synergistic effect with combination of cyclophosphamide. The antitumor activity of rIFN-alpha A/D was observed by intra-muscular, intravenous, subcutaneous, intraperitoneal injections or by the injection at the site of the tumors.
Ootsu
K
K
Kozai
Y
Y
Houkan
T
T
Gotoh
K
K
Matsutani
E
E
D000818:Animals; D005260:Female; D005354:Fibrosarcoma / Q000628:therapy; D007370:Interferon Type I / Q000627:therapeutic use*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000628:therapy; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use
D007370:Interferon Type I; D011994:Recombinant Proteins