title: [Influences of percutaneous nephrolithotomy on renal function, an observation using the NAG-index and beta 2-microglobulin as indices].
abstract: To examine the influence of percutaneous nephrolithotomy (PNL) on renal function, we measured the activity of urinary N-acetyl-beta-D-glucosaminidase (NAG) and beta 2-microglobulin (beta 2MG) in patients with nephrolithiasis, before and 3, 5, 7, 14 days and 1 month after PNL. With PNL, renal function was recovered within one month, and PNL was thought to be a more protective method than pyelolithotomy. Recovery of renal function was delayed in the cases in which PNL had been attempted over three times. In the patients with preoperative high-grade hydronephrosis, the excretion of NAG and beta 2MG in the urine was delayed. NAG-index was considered to be a more sensitive parameter than beta 2MG to evaluate renal function. The NAG-index and beta 2MG values of bladder urine were in good correlation with those of nephrostomy urine 5 days or more postoperatively. Measurement of the urinary NAG-index 3, 7, 14, 30 days after PNL operation was considered valuable for determining changes in renal function.
authors.affiliation: Department of Urology, Nippon Medical University.
authors.forename: I
authors.initials: I
authors.lastname: Yajima
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Tomita
authors.forename: N
authors.initials: N
authors.lastname: Hikima
authors.forename: N
authors.initials: N
authors.lastname: Kawamura
authors.forename: N
authors.initials: N
authors.lastname: Tsuboi
authors.forename: R
authors.initials: R
authors.lastname: Honda
authors.forename: M
authors.initials: M
authors.lastname: Akimoto
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D000368:Aged; D005260:Female; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D007668:Kidney / Q000503:physiopathology / Q000601:surgery*; D007669:Kidney Calculi / Q000601:surgery*; D008297:Male; D008722:Methods; D008875:Middle Aged; D011184:Postoperative Period; D001613:beta 2-Microglobulin / Q000652:urine*
chemical_list: D001613:beta 2-Microglobulin; D006596:Hexosaminidases; D000118:Acetylglucosaminidase