title: Repeat cadaver kidney transplantation using cyclosporine A immunosuppression.
abstract: Repeat cadaver kidney transplantation using azathioprine immunosuppression carried a higher risk of graft loss than primary transplants. We analyzed the results of repeat cadaver kidney grafting with cyclosporine A immunosuppression. A total of 33 cyclosporine A-treated patients received the second kidney transplant at varying intervals after failure of the first transplant. Graft survival at 1 year was 66 per cent. A concurrent group of 189 cyclosporine A-treated first cadaver kidney recipients had a 1-year graft survival rate of 75 per cent, although this better result was not statistically significant (p greater than or equal to 0.25). A historical group of 31 azathioprine-treated second graft recipients had a significantly worse 1-year graft survival rate of 45 per cent compared to the cyclosporine A second graft group (p less than 0.1). Patient age, sex, early first graft loss, interval between transplants and the presence of panel reactive antibodies were not factors in predicting second graft outcome. A complete DR mismatch appeared to worsen the second transplant survival. These findings indicate that early graft survival of cyclosporine A-treated repeat cadaveric transplants is acceptable and is better than azathioprine-treated first or second grafts.
authors.affiliation: Transplant Unit, Victoria General Hospital, Halifax, Nova Scotia, Canada.
authors.forename: P A
authors.initials: PA
authors.lastname: Anderson
authors.forename: P
authors.initials: P
authors.lastname: Belitsky
authors.forename: H
authors.initials: H
authors.lastname: Bitter-Suermann
authors.forename: A D
authors.initials: AD
authors.lastname: Cohen
authors.forename: A S
authors.initials: AS
authors.lastname: MacDonald
mesh_terms: D000206:Actuarial Analysis; D000367:Age Factors; D002102:Cadaver; D003524:Cyclosporins / Q000627:therapeutic use*; D006084:Graft Rejection; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D016030:Kidney Transplantation; D012086:Reoperation; D012307:Risk Factors; D013997:Time Factors
chemical_list: D003524:Cyclosporins