title: Alpha-tocopherol: effect on plasma lipoproteins in hypercholesterolemic patients.
abstract: This study was designed to examine the hypothesis that dl-alpha-tocopheryl acetate (vitamin E) increases the level of high-density lipoprotein cholesterol (HDLC) with a concomitant decrease of the ratio of total cholesterol/HDLC and a resultant amelioration of the coronary risk profile. Vitamin E (500 IU/day) or placebo were administered under double-blind randomized allocation to 69 hypercholesterolemic patients for 3 months. Sixty patients completed the study (30 in the active treatment group and 30 in the placebo group). Vitamin E raised the mean level of HDLC from 1.39 +/- 0.38 (SD) to 1.58 +/- 0.41 mmol, a 13.6% increase. This increase significantly (P less than 0.05) exceeded a parallel smaller increase of only 0.05 mmol (3.8%) in the placebo group. As total cholesterol (TC) declined by similar proportions in the vitamin E (7.8%) and placebo (9.4%) groups, a concomitant reduction of 23% in the TC/HDLC ratio was achieved in the vitamin E group, significantly exceeding a 9.1% reduction under placebo. Significant beneficial effects were noted on apolipoprotein (Apo) A (which rose) and Apo B (which declined). An increase of Apo A/Apo B ratio by 17.9% was observed only in the vitamin E group. These results suggest that the oral administration of vitamin E (500 IU/day) is beneficial in hyperlipoproteinemia and offers a potential tool for treating the increased coronary heart disease risk.
authors.affiliation: Hôpital Tenon, Polyclinique Medicale, Paris, France.
authors.forename: M J
authors.initials: MJ
authors.lastname: Cloarec
authors.forename: G M
authors.initials: GM
authors.lastname: Perdriset
authors.forename: F A
authors.initials: FA
authors.lastname: Lamberdiere
authors.forename: J F
authors.initials: JF
authors.lastname: Colas-Belcour
authors.forename: J P
authors.initials: JP
authors.lastname: Sauzieres
authors.forename: H N
authors.initials: HN
authors.lastname: Neufeld
authors.forename: U
authors.initials: U
authors.lastname: Goldbourt
mesh_terms: D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008297:Male; D011897:Random Allocation; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D014810:Vitamin E