Effect of chronically elevated androgen or estrogen on the glucose tolerance test and insulin response in female rhesus monkeys.
Insulin concentrations, in response to an intravenous glucose bolus after a 24-hour fast, have been studied in female rhesus monkeys in which the circulating levels of androstenedione and testosterone or estrone and estradiol have been increased for as long as 4 1/2 years. No significant differences were observed in the basal insulin or C-peptide concentrations in the androgen or estrogen-treated animals compared with each other or with normal cycling, nontreated control animals. The insulin and C-peptide responses to intravenous glucose were similar in control and androgen-treated monkeys. Compared with both the control and androgen-treated monkeys, the responses of the estrogen-treated monkeys tended to be lower but were not significantly different. The glucose disappearance rate after the intravenous glucose bolus was not significantly different in androgen and control monkeys but was significantly slower during the initial 30 minutes in the estrogen-treated monkeys compared with both the control and androgen-treated monkeys. These studies suggest that chronically elevated androgen levels in the mature female subhuman primate do not lead to insulin resistance or overt glucose intolerance.
Billiar
R B
RB
Department of Obstetrics and Gynecology, McGill University Faculty of Medicine, Montreal, Quebec, Canada.
Richardson
D
D
Schwartz
R
R
Posner
B
B
Little
B
B
D000735:Androstenedione / Q000097:blood* / Q000494:pharmacology; D000818:Animals; D002096:C-Peptide / Q000097:blood; D004958:Estradiol / Q000097:blood*; D004970:Estrone / Q000097:blood* / Q000494:pharmacology; D005260:Female; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008253:Macaca mulatta; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
D002096:C-Peptide; D007328:Insulin; D004970:Estrone; D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol