The "in situ" immune response in lymph nodes: a review.
For many years data on the development of specific antibody-forming cells in lymph nodes were incomplete, fragmentary, and even contradictory. A number of recent studies have been performed, concerning 1) their overall architecture; 2) migration of B-lymphocytes; 3) localization of accessory cells and T-lymphocytes which are believed to be involved in humoral immune responses; and 4) localization patterns of specific antibody-forming cells developing during thymus dependent and thymus independent immune responses. Comparison of these new results with those of earlier studies suggests a single route of migration followed by all cells which will differentiate into antibody-forming cells. During their differentiation into antibody-forming plasma cells, antigen reactive B-cells migrate along the required accessory cells and/or T-lymphocytes.
van Rooijen
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Department of Histology, Medical Faculty, Free University, Amsterdam, The Netherlands.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000502:physiology*; D000941:Antigens / Q000276:immunology; D002465:Cell Movement; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology*
D000941:Antigens