Pharmacological properties of besulpamide, a new diuretic, in rats and dogs.
Besulpamide, a newly synthesized compound, has demonstrated significant diuretic activity in rats and dogs, similar to that of chlorthalidone, clopamide and xipamide. Antihypertensive activity of besulpamide is similar to that of hydrochlorothiazide and was demonstrated in rat one-kidney desoxycorticosterone acetate (DOCA)-salt hypertension. In addition, besulpamide, like hydrochlorothiazide, potentiated the antihypertensive activity of captopril in spontaneously hypertensive rats (SHR). Doses of besulpamide exceeding those normally required for pharmacological activity did not evoke adverse reactions in rats and mice.
Colombo
M
M
Farré
A J
AJ
Fort
M
M
Martínez
L
L
Roser
R
R
Sagarra
R
R
D000818:Animals; D000959:Antihypertensive Agents; D002216:Captopril / Q000494:pharmacology; D003900:Desoxycorticosterone / Q000037:antagonists & inhibitors; D004232:Diuretics; D004285:Dogs; D004357:Drug Synergism; D008297:Male; D051379:Mice; D011726:Pyridinium Compounds / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains
D000959:Antihypertensive Agents; D004232:Diuretics; D011726:Pyridinium Compounds; C052513:besulpamide; D003900:Desoxycorticosterone; D002216:Captopril