Intracellular Ca2+ in pancreatic acinar cells: regulation and role in stimulation of enzyme secretion.
Evidence for a primary role for intracellular Ca2+ in the stimulation of pancreatic enzyme secretion is reviewed. Measurements of cytoplasmic free Ca2+ concentration have allowed direct demonstration of its importance in triggering enzyme secretion and defined the concentration range over which membrane Ca2+ pumps must work to regulate intracellular Ca2+. Current evidence suggests a key role for the Ca2+, Mg-ATPase of rough endoplasmic reticulum in regulating intracellular Ca2+ and accumulating a Ca2+ store which is released by the action of inositol-1,4,5 trisphosphate following stimulation of secretion.
Dormer
R L
RL
Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK.
Brown
G R
GR
Doughney
C
C
McPherson
M A
MA
D000818:Animals; D002118:Calcium / Q000502:physiology*; D005089:Exocytosis; D010179:Pancreas / Q000166:cytology / Q000201:enzymology*
D002118:Calcium