Ability of the phenolic glycolipid-I antigen of M. leprae to elicit a positive Mitsuda response in the armadillo (Dasypus novemcinctus).
Three lepromin-positive armadillos and three lepromin-negative armadillos were tested intradermally with 100 micrograms of phenolic glycolipid-I (PGL-I) in 0.1 ml of normal saline. Positive delayed-hypersensitivity granulomas at 21 days in the lepromin-positive animals and negative responses in the lepromin-negative animals were obtained. These observations suggest that purified PGL-I is capable of eliciting cell-mediated immune or delayed-hypersensitivity responses in animals sensitized to Mycobacterium leprae.
Job
C K
CK
Sanchez
R M
RM
McCormick
G T
GT
Hastings
R C
RC
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001135:Armadillos / Q000276:immunology*; D006017:Glycolipids / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D007916:Lepromin / Q000276:immunology*; D009166:Mycobacterium leprae / Q000276:immunology*; D004490:Xenarthra / Q000276:immunology*
D000942:Antigens, Bacterial; D006017:Glycolipids; C045169:phenolic glycolipid I, Mycobacterium leprae; D007916:Lepromin