title: Synthesis and antifungal activity of new 1-vinylimidazoles.
abstract: Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III. Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imidazole transfer reaction, were alkylated to furnish the title compounds V. The structure-activity relationships of these 1-vinylimidazole compounds V are described.
authors.forename: M
authors.initials: M
authors.lastname: Ogata
authors.forename: H
authors.initials: H
authors.lastname: Matsumoto
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: S
authors.initials: S
authors.lastname: Kida
authors.forename: M
authors.initials: M
authors.lastname: Shiro
authors.forename: K
authors.initials: K
authors.lastname: Tawara
mesh_terms: D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003022:Clotrimazole / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014249:Trichophyton / Q000187:drug effects; D014753:Vinyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D007093:Imidazoles; D014753:Vinyl Compounds; D003022:Clotrimazole