title: Chromosomal analysis of bladder cancer. III. Nonrandom alterations.
abstract: Chromosome analysis using G- and C-banding was performed on 13 primary transitional cell carcinomas of the bladder. The chromosome preparations were obtained by a direct method. In eight tumors with a (near) diploid modal chromosome number, the most frequently observed chromosome aberrations were: (partial) monosomy 9 in four cases, deletion of 10q in two cases, and partial trisomy 1 in two cases. In five tumors with a modal chromosome number in the triploid or tetraploid range the chromosomes #1, #3, #7, #9, #11, and #17 were numerically and or structurally abnormal in at least four cases. In three out of ten males, the Y chromosome was missing. These findings suggest that the loss of chromosome #9, and possibly also loss of 10q is a primary event in the karyotypic evolution of transitional cell carcinoma of the bladder.
authors.affiliation: Stichting Ziekenhuisapotheek en Klinisch Laboratorium, Venray, The Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Smeets
authors.forename: R
authors.initials: R
authors.lastname: Pauwels
authors.forename: L
authors.initials: L
authors.lastname: Laarakkers
authors.forename: F
authors.initials: F
authors.lastname: Debruyne
authors.forename: J
authors.initials: J
authors.lastname: Geraedts
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D011003:Ploidies; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
chemical_list: D005819:Genetic Markers