title: Pharmacological properties of besulpamide, a new diuretic, in rats and dogs.
abstract: Besulpamide, a newly synthesized compound, has demonstrated significant diuretic activity in rats and dogs, similar to that of chlorthalidone, clopamide and xipamide. Antihypertensive activity of besulpamide is similar to that of hydrochlorothiazide and was demonstrated in rat one-kidney desoxycorticosterone acetate (DOCA)-salt hypertension. In addition, besulpamide, like hydrochlorothiazide, potentiated the antihypertensive activity of captopril in spontaneously hypertensive rats (SHR). Doses of besulpamide exceeding those normally required for pharmacological activity did not evoke adverse reactions in rats and mice.
authors.forename: M
authors.initials: M
authors.lastname: Colombo
authors.forename: A J
authors.initials: AJ
authors.lastname: Farré
authors.forename: M
authors.initials: M
authors.lastname: Fort
authors.forename: L
authors.initials: L
authors.lastname: Martínez
authors.forename: R
authors.initials: R
authors.lastname: Roser
authors.forename: R
authors.initials: R
authors.lastname: Sagarra
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents; D002216:Captopril / Q000494:pharmacology; D003900:Desoxycorticosterone / Q000037:antagonists & inhibitors; D004232:Diuretics; D004285:Dogs; D004357:Drug Synergism; D008297:Male; D051379:Mice; D011726:Pyridinium Compounds / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D011726:Pyridinium Compounds; C052513:besulpamide; D003900:Desoxycorticosterone; D002216:Captopril