title: Thyroid function in leukaemia patients after allogeneic bone marrow transplantation.
abstract: The thyroid function of 29 patients who underwent allogeneic bone marrow transplantation preceded by total body irradiation was followed closely during four weeks after transplantation. Twenty patients showed a marked decrease of T3 and TSH levels, whereas T4 fluctuated. Long-term follow up from three to five years of the surviving 16 patients revealed a restoration of the T3 levels to normal, a slight increase in T4 levels and a doubling of the TSH levels. This indicates the necessity of a higher pituitary drive to maintain euthyroidism. One patient developed hypothyroidism.
authors.affiliation: Department of Chemical Pathology, University Hospital, Leiden, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Frölich
authors.forename: M M
authors.initials: MM
authors.lastname: de Planque
authors.forename: B M
authors.initials: BM
authors.lastname: Goslings
authors.forename: A E
authors.initials: AE
authors.lastname: Meinders
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007938:Leukemia / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D012737:Sex Factors; D013961:Thyroid Gland / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood; D014916:Whole-Body Irradiation
chemical_list: D003520:Cyclophosphamide; D013972:Thyrotropin