title: [Malignant transformation and changes in various physico-chemical properties of macromolecules and supramolecular structures. I. Nucleic acids].
abstract: The relations between heat and hydrate properties of nucleic acids, proteins and supramolecular structures and concentration of various metal ions in them are shown. Global disturbance of metabolism of metal ions accompanying malignization is described. This disturbance causes some changes in the activity of the central nervous system. Recently there were found disturbances of physico-chemical properties of some (most characteristic) brain regions during the development of malignant tumors in the mammary glands and spleen.
authors.forename: E L
authors.initials: EL
authors.lastname: Andronikashvili
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000378:metabolism*; D046911:Macromolecular Substances; D051379:Mice; D009363:Neoplasm Proteins / Q000378:metabolism; D009691:Nucleic Acid Denaturation; D051381:Rats
chemical_list: D004273:DNA, Neoplasm; D046911:Macromolecular Substances; D009363:Neoplasm Proteins
vernacular_title: Malignizatsiia i izmenenie nekotorykh fiziko-khimicheskikh svoĭstv biomakromolekul i nadmolekuliarnykh struktur. I. Nukleinovye kisloty.