PAG stimulation does not affect primary antibody responses in rats.
Adult male rats, which had electrodes chronically implanted in the periaqueductal gray (PAG), were immunized with sheep red blood cells (SRBCs). The number of direct and indirect plaque-forming cells (PFCs) in the group receiving PAG stimulation after immunization did not differ significantly from that in the unstimulated group. Thus, the results indicate that short-term PAG stimulation does not suppress antibody-producing activity in the rat.
Noguchi
Ryoko
R
Department of Anesthesiology, Niigata University School of Medicine, Niigata 951 Japan Department of Virology, Niigata University School of Medicine, Niigata 951 Japan.
Hamada
Chuya
C
Shimoji
Koki
K
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000502:physiology; D004558:Electric Stimulation; D004580:Electronarcosis; D006462:Hemolytic Plaque Technique; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008297:Male; D010487:Periaqueductal Gray / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology
D007074:Immunoglobulin G; D007075:Immunoglobulin M