A postulated role for naturally occurring aromatase inhibitors in follicle selection.
The studies reviewed here indicate that follicle regulatory protein (FRP) alters aromatase and 3B-hydroxysteroid dehydrogenase activity in porcine, human, and rat granulosa cells. The inhibitory effect of FRP on granulosal aromatase activity depend upon the response of the cell to FSH: large amounts of FSH can partially overcome FRP inhibition while relatively small amounts of FSH sensitize the granulosal aromatase system to FRP. Although androgens potentiate FSH-mediated granulosal functions, they also sensitize granulosa cell steroidogenic enzymes to inhibition by FRP. The demonstration that FRP acts primarily on granulosa cells of less mature antral follicles to inhibit aromatase supports the hypothesis that FRP may facilitate follicle selection and suggests a role for FRP in atresia. Most of the effects of FRP on granulosal activities reflect an interplay between the systemic endocrine and local paracrine systems. That FRP functions, at least in part, by modulating follicular response to FSH is consistent with the hypothesis that paracrine effectors are important mediators of folliculogenesis in the presence of gonadotropins.
DiZerega
G S
GS
Livingston Reproductive Biology Laboratory, University of Southern California School of Medicine, Los Angeles 90033.
Tonetta
S A
SA
Westhof
G
G
D015096:3-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D047072:Aromatase Inhibitors; D001826:Body Fluids / Q000032:analysis; D006063:Chorionic Gonadotropin / Q000378:metabolism; D005260:Female; D006107:Granulosa Cells / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D006080:Ovarian Follicle / Q000502:physiology*; D010455:Peptides / Q000302:isolation & purification / Q000502:physiology*; D051381:Rats; D011974:Receptors, LH / Q000378:metabolism; D013256:Steroids / Q000096:biosynthesis; D013552:Swine; D013799:Theca Cells / Q000378:metabolism
D047072:Aromatase Inhibitors; D006063:Chorionic Gonadotropin; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D011974:Receptors, LH; D013256:Steroids; C018355:intraovarian peptides; D015096:3-Hydroxysteroid Dehydrogenases; D000262:Adenylyl Cyclases