Influence of indomethacin on the endotoxin-induced cardiodepressant effect of serum and steroid hormone changes in male rats.
Escherichia coli endotoxin has been shown to induce a cardiodepressant effect (CDE) and changes in steroid hormone concentrations in the serum of male rats, especially increases in estrogens and a decrease in testosterone. Pretreatment of rats with indomethacin (INDO) abolished these responses to endotoxin. Direct addition of INDO to primary cultures of rat heart cells blocked the cardiodepressant response of these cells to endotoxin-treated rat serum. These data, together with previous results, suggest that relationships between estrogens and CDE are possible, while these two parameters have different time courses and dose dependencies; in any case, the prostanoid system is likely involved since INDO is able to suppress both of them.
Nunez
E A
EA
Christeff
N
N
Auclair
M C
MC
Benassayag
C
C
Carli
A
A
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins; D004926:Escherichia coli; D004967:Estrogens / Q000097:blood; D006728:Hormones / Q000097:blood*; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic / Q000097:blood*
D004731:Endotoxins; D004967:Estrogens; D006728:Hormones; D007213:Indomethacin