title: Thymic hormone modulation of CD38 (T10) antigen on human cord blood lymphocytes.
abstract: We studied the in vitro effect of three different thymic factors on the expression of CD38 (T10) antigen on cord T-lymphoid cell surface. The results showed that cord mononuclear cell populations contain variable percentages of CD38+ cells. The CD38 molecule was expressed on cord T and B lymphocyte and monocyte surfaces. Incubation with thymic agents induced a significant increases in the CD38+ cell percentage only in the samples with low CD38 antigen expression, and this modulation was mainly attributable to the T-cell subset. The effect seems to be specific and not correlated with the known high spontaneous DNA synthesis rate of cord mononuclear cells.
authors.affiliation: Instituto di Clinica Medica I, University of Perugia Medical School, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Gerli
authors.forename: A
authors.initials: A
authors.lastname: Bertotto
authors.forename: F
authors.initials: F
authors.lastname: Spinozzi
authors.forename: C
authors.initials: C
authors.lastname: Cernetti
authors.forename: A
authors.initials: A
authors.lastname: Battaglia
authors.forename: R
authors.initials: R
authors.lastname: Falchetti
authors.forename: F
authors.initials: F
authors.lastname: Grignani
authors.forename: P
authors.initials: P
authors.lastname: Rambotti
mesh_terms: D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1; D000328:Adult; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000276:immunology*; D005312:Fetal Blood / Q000166:cytology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007065:Idoxuridine / Q000378:metabolism; D007231:Infant, Newborn; D008562:Membrane Glycoproteins; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology* / Q000378:metabolism; D013951:Thymus Hormones / Q000494:pharmacology*
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D008562:Membrane Glycoproteins; D013951:Thymus Hormones; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1; D007065:Idoxuridine