Hyperinsulinemia and hypertension in patients with newly diagnosed non-insulin-dependent diabetes.
An increased occurrence of hypertension was observed in a group of patients (N = 133) with newly diagnosed non-insulin-dependent diabetes as compared to non-diabetic control subjects (N = 144). In men the excessive occurrence of hypertension in diabetics seemed to be mainly confined to obese subjects, whereas in women it occurred both in obese and non-obese subjects. Fasting or postglucose serum insulin levels showed a positive correlation with blood pressure levels in non-diabetic men and in diabetic and non-diabetic women even after adjustment of insulin for obesity.
Uusitupa
M
M
Department of Medicine, University of Kuopio, Finland.
Niskanen
L
L
Siitonen
O
O
Pyörälä
K
K
D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D048909:Diabetes Complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol