title: Evaluation of diagnostic criteria for Leydig cell tumours in adult men revealed by gynaecomastia.
abstract: Gynaecomastia caused by Leydig cell tumours (LCT) in adult men may appear a long time before clinical evidence of testicular swelling. To evaluate the diagnostic criteria for LCT, hormonal status was studied in 14 cases and compared with results of a control group (CG) and 10 men with idiopathic gynaecomastia (IG). The mean plasma T level was significantly (P less than 0.005) lower in LCT (16.7 +/- 1.7 SEM nmol/l) than in CG (23.0 +/- 1.3 nmol/l). However, individual plasma T levels were in the normal range in 9/14 LCT. The mean plasma E2 level was significantly (P less than 0.001) higher in LCT (204.9 +/- 27.6 pmol/l) than in CG (87.9 +/- 7.7 pmol/l). However, individual plasma E2 levels were in the normal range in 5/14 LCT. In LCT, neither means of basal gonadotrophin levels nor the gonadotrophin responses to LHRH were different from CG. The mean of the plasma T responses to hCG did not differ between LTC, CG and IG. However the mean of E2 peak responses appeared significantly (P less than 0.005) higher in LCT (735.3 +/- 103.4 pmol/l) than in CG (420.5 +/- 40.4 pmol/l). The mean of the E2 peak responses was significantly (P less than 0.001) lower in IG (196.5 +/- 33.4 pmol/l) than in CG. Likewise the mean of plasma E2 levels, measured on day three following hCG administration, remained significantly (P less than 0.001) higher in LCT (662 +/- 94 pmol/l) than either in CG (228 +/- 14 pmol/l) or in IG (158 +/- 25 pmol/l). On day 3 following hCG administration, there was no overlap in individual plasma E2 levels between either LCT and CG or LCT and IG. In all LCT, plasma beta-hCG levels were in the normal range. A testicular echogram, performed in 12 LCT, confirmed the presence of a palpable tumour in 10 and revealed an occult tumour in two cases. We conclude that normal plasma beta-hCG levels, a prolonged plasma E2 response to hCG and testicular echogram appear to be the best criteria for early diagnosis of LCT responsible for gynaecomastia in adult men.
authors.affiliation: Centre de Recherches Endocrinologiques, hôpital Cochin, Paris, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Kuhn
authors.forename: J A
authors.initials: JA
authors.lastname: Mahoudeau
authors.forename: L
authors.initials: L
authors.lastname: Billaud
authors.forename: J
authors.initials: J
authors.lastname: Joly
authors.forename: M
authors.initials: M
authors.lastname: Rieu
authors.forename: A
authors.initials: A
authors.lastname: Gancel
authors.forename: F
authors.initials: F
authors.lastname: Archambeaud-Mouveroux
authors.forename: A
authors.initials: A
authors.lastname: Steg
authors.forename: J P
authors.initials: JP
authors.lastname: Luton
mesh_terms: D000328:Adult; D004958:Estradiol / Q000097:blood; D005069:Evaluation Studies as Topic; D006062:Gonadotropins / Q000097:blood; D006177:Gynecomastia / Q000209:etiology*; D006801:Humans; D007984:Leydig Cell Tumor / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D013736:Testicular Neoplasms / Q000175:diagnosis*; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography
chemical_list: D006062:Gonadotropins; D013739:Testosterone; D004958:Estradiol