title: Cimetidine and chlorpheniramine in the treatment of chronic idiopathic urticaria: a multi-centre randomized double-blind study.
abstract: One hundred and twenty patients with chronic idiopathic urticaria, who entered a study at five centres (Sheffield, London, Bristol, Cardiff and Leeds) were treated with therapeutic doses of the H1 antagonist chlorpheniramine for 6 weeks. Histamine H1 non-responders (40 patients) were entered into a double-blind study and received chlorpheniramine plus cimetidine 400 mg q.d.s. (21 patients) or chlorpheniramine plus placebo (19 patients) for a further 8 weeks. The most important response measure was the change from baseline of the total symptom score: an assessment of the number and duration of new weals and degree of itching. There was a statistically significant difference between the average response in the two treatment groups in favour of chlorpheniramine plus cimetidine after 4 and 8 weeks' treatment (P less than 0.05 and P less than 0.01, respectively). No significant side-effects related to treatment were noted.
authors.affiliation: Royal Hallamshire Hospital, Sheffield, U.K.
authors.forename: S S
authors.initials: SS
authors.lastname: Bleehen
authors.forename: S E
authors.initials: SE
authors.lastname: Thomas
authors.forename: M W
authors.initials: MW
authors.lastname: Greaves
authors.forename: J
authors.initials: J
authors.lastname: Newton
authors.forename: C T
authors.initials: CT
authors.lastname: Kennedy
authors.forename: F
authors.initials: F
authors.lastname: Hindley
authors.forename: R
authors.initials: R
authors.lastname: Marks
authors.forename: M
authors.initials: M
authors.lastname: Hazell
authors.forename: N R
authors.initials: NR
authors.lastname: Rowell
authors.forename: G M
authors.initials: GM
authors.lastname: Fairiss
mesh_terms: D002744:Chlorpheniramine / Q000009:adverse effects / Q000627:therapeutic use*; D002927:Cimetidine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D011897:Random Allocation; D012867:Skin / Q000473:pathology; D014581:Urticaria / Q000188:drug therapy* / Q000473:pathology
chemical_list: D002744:Chlorpheniramine; D002927:Cimetidine