Calcium antagonists and blood glucose in normal rabbits.
The effects of the calcium antagonists verapamil and nifedipine on blood glucose levels, glucose tolerance, insulin secretion during glucose tolerance and hypoglycaemic effect of tolbutamide were studied in normal nondiabetic rabbits. Daily dosage of 40 mg/kg verapamil and 5 mg/kg nifedipine given orally up to 7 days did not affect blood glucose level, glucose tolerance, insulin secretion during glucose tolerance and hypoglycaemic activity of tolbutamide 250 mg/kg p.o.
Patel
R B
RB
Shah
G F
GF
Raval
J D
JD
Gandhi
T P
TP
Gilbert
R N
RN
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D009543:Nifedipine / Q000494:pharmacology; D011817:Rabbits; D014044:Tolbutamide / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D001786:Blood Glucose; D002121:Calcium Channel Blockers; D007328:Insulin; D014044:Tolbutamide; D014700:Verapamil; D009543:Nifedipine