title: Regulation of rCBF by intracortical vasoactive intestinal polypeptide-containing neurons. Immunohistochemical and hydrogen clearance study in rats.
abstract: The role of intracortical vasoactive intestinal polypeptide (VIP)-containing neurons in the regulation of cortical blood flow was investigated in rats by immunohistochemical and hydrogen clearance methods. Immunohistochemical studies revealed an intimate association between intracortical VIP-containing neurons and small blood vessels. Intracortical injection of a VIP solution (10(-5) M) produced significantly higher blood flow in the treated cortex (mean +/- standard error of the mean: 46.2 +/- 4.0 ml/100 gm/min) than in the untreated cortex (36.9 +/- 2.4 ml/100 gm/min). These data suggest that intracortical VIP-containing neurons produce dilatation of intracortical blood vessels.
authors.forename: T
authors.initials: T
authors.lastname: Itakura
authors.forename: H
authors.initials: H
authors.lastname: Yokote
authors.forename: T
authors.initials: T
authors.lastname: Okuno
authors.forename: Y
authors.initials: Y
authors.lastname: Naka
authors.forename: K
authors.initials: K
authors.lastname: Nakakita
authors.forename: I
authors.initials: I
authors.lastname: Kamei
authors.forename: K
authors.initials: K
authors.lastname: Nakai
authors.forename: H
authors.initials: H
authors.lastname: Imai
authors.forename: N
authors.initials: N
authors.lastname: Komai
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000032:analysis* / Q000166:cytology / Q000502:physiology; D002560:Cerebrovascular Circulation; D006859:Hydrogen; D007124:Immunoenzyme Techniques; D009412:Nerve Fibers / Q000032:analysis* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D014660:Vasoactive Intestinal Peptide / Q000032:analysis*
chemical_list: D014660:Vasoactive Intestinal Peptide; D006859:Hydrogen