The gerontological decline of the renin-aldosterone system: a chronobiological approach extended to essential hypertension.
The circadian (about 24-hr) oscillating function of the renin-angiotensin-aldosterone system (RAAS) was investigated as a function of age in clinically healthy participants and in essential hypertensive patients. A peculiar age-related decline in the RAAS circadian mesor (rhythm-adjusted mean) and amplitude (variability from mesor) was found in the essential hypertensive patients. This finding suggests a nonphysiologic evolution in the tonic (24-hr mean level) as well as phasic (oscillating amplitude) circadian activity of the RAAS with increasing age. A relative hyperreninemic aldosteronism characterized the aged essential hypertensive patients.
Cugini
P
P
Murano
G
G
Lucia
P
P
Letizia
C
C
Scavo
D
D
Halberg
F
F
Schramm
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D000450:Aldosterone / Q000097:blood; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System
D000450:Aldosterone; D012083:Renin