[Participation of leu-enkephalin in regulating carbohydrate metabolism].
The experiments have been performed on 166 white male rats with a mass of 180-220 g. It has been revealed that leucine-enkephalin and its synthetic analogs prevent an increase in glucose blood levels and a decrease in glycogen liver levels caused by adrenaline and parathyroid hormone. At the same time the enkephalins inhibit the secretory activity of pancreatic beta-cells. The mechanisms of opioid peptide effect on carbohydrate metabolism are discussed.
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D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D050260:Carbohydrate Metabolism; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D004837:Epinephrine / Q000494:pharmacology; D007328:Insulin / Q000097:blood; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010281:Parathyroid Hormone / Q000494:pharmacology; D051381:Rats
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D008112:Liver Glycogen; D010281:Parathyroid Hormone; D009270:Naloxone; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-; D004837:Epinephrine
Ob uchastii leĭ-énkefalina v reguliatsii uglevodnogo obmena.