Effects of L-timolol, D-timolol, haloperidol and domperidone on rabbit retinal blood flow measured with laser Doppler method.
L-Timolol (0.4 mg/kg) reduced significantly retinal blood flow (17%), systemic blood pressure (18-20%) and heart rate (28%) in the rabbit. D-Timolol (4.0 mg/kg) increased retinal blood flow slightly (9%) and did not significantly affect systemic blood pressure or heart rate. Since D-timolol is effective in reducing intraocular pressure, these results indicate that D-timolol is superior to L-timolol for glaucoma treatment. Haloperidol and domperidone are dopamine antagonists, but, while haloperidol (0.1 mg/kg) suppressed retinal blood flow (16%), domperidone (0.2 mg/kg) increased it (12%). Neither of them affected blood pressure or heart rate significantly. While either of these given topically decreases intraocular pressure significantly, domperidone's ability to increase retinal blood flow makes it more useful than either haloperidol or L-timolol for treating glaucoma.
Yan
H Y
HY
Chiou
G C
GC
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004294:Domperidone / Q000494:pharmacology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D012171:Retinal Vessels / Q000187:drug effects / Q000502:physiology*; D013237:Stereoisomerism; D013999:Timolol / Q000494:pharmacology*; D014463:Ultrasonography
D004294:Domperidone; D013999:Timolol; D006220:Haloperidol