title: [Allogenic bone marrow grafts in chronic myeloid leukemia].
abstract: Between August 1979 and April 1986, we treated 70 patients with chronic myeloid leukemia by supralethal chemoradiotherapy followed by bone marrow transplantation (BMT) from HLA identical sibling donors (65 patients) or from identical twins (5 patients). All patients were splenectomized before BMT. To prevent graft versus host disease Cyclosporin alone or associated with Methotrexate was given; in addition 13 patients received a T cell depleted marrow. All patients showed engraftment. Of the 5 patients treated by syngenic BMT, 2 patients relapsed but all are alive in remission, 2 of them after a successful second BMT. Of the 36 patients treated by allogeneic BMT in the chronic phase, 20 are alive in unmaintained remission after a median follow-up of 24 months (range 6 to 58). No patients have relapsed. The actuarial survival at 2 years was 60%. Of the 29 patients with more advanced disease, 19 have survived with the actuarial survival at 2 years 50%. We conclude that the probability of cure after BMT is very high, especially if BMT is performed while the patient remains in the chronic phase. Only 3 patients grafted in accelerated or blast phase died with relapse. The main cause of death was interstitial pneumonitis (15 patients) and 10 patients died from other transplant-related complications.
authors.forename: A
authors.initials: A
authors.lastname: Devergie
authors.forename: E
authors.initials: E
authors.lastname: Gluckman
authors.forename: F
authors.initials: F
authors.lastname: Varrin
authors.forename: J L
authors.initials: JL
authors.lastname: Huret
authors.forename: J
authors.initials: J
authors.lastname: Meletis
authors.forename: H
authors.initials: H
authors.lastname: De Castro
authors.forename: D
authors.initials: D
authors.lastname: Bombail
authors.forename: E
authors.initials: E
authors.lastname: Vilmer
authors.forename: R
authors.initials: R
authors.lastname: Traineau
authors.forename: M
authors.initials: M
authors.lastname: Boiron
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D007951:Leukemia, Myeloid / Q000628:therapy*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D011292:Premedication; D013156:Splenectomy
chemical_list: D008727:Methotrexate
vernacular_title: La greffe de moelle osseuse allogénique dans la leucémie myéloïde chronique.