Ticarcillin disodium/clavulanate potassium versus clindamycin/gentamicin in the treatment of postpartum endometritis.
Ticarcillin disodium/clavulanate potassium was compared to clindamycin/gentamicin in the treatment of post-cesarean-section endometritis in 133 evaluable patients. All patients received three 1-g doses of cefazolin for prophylaxis. There was no statistically significant difference in the cure rates between the ticarcillin disodium/clavulanate potassium group (84%) and the clindamycin/gentamicin group (81%). Bacteremia occurred in 21% of the patients, with Mycoplasma the most frequent isolate. Ticarcillin disodium/clavulanate potassium was found to be as efficacious as clindamycin/gentamicin in the treatment of postpartum endometritis.
Faro
S
S
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030.
Martens
M
M
Phillips
L E
LE
Hamill
H
H
Smith
D
D
Riddle
G
G
D002437:Cefazolin / Q000627:therapeutic use; D002585:Cesarean Section; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000627:therapeutic use*; D002981:Clindamycin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D004716:Endometritis / Q000188:drug therapy*; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D009175:Mycoplasma Infections / Q000188:drug therapy; D010406:Penicillins / Q000627:therapeutic use*; D011247:Pregnancy; D011292:Premedication; D011645:Puerperal Infection / Q000188:drug therapy*; D013982:Ticarcillin / Q000627:therapeutic use*; D065093:beta-Lactamase Inhibitors
D002969:Clavulanic Acids; D004338:Drug Combinations; D005839:Gentamicins; D010406:Penicillins; D065093:beta-Lactamase Inhibitors; D019818:Clavulanic Acid; D002981:Clindamycin; D013982:Ticarcillin; D002437:Cefazolin