Recovery of luteal function after interruption of gonadotrophin secretion in the mid-luteal phase of the menstrual cycle.
Ovulation was induced by a pulsatile infusion of GnRH in a patient with hypogonadotrophic amenorrhoea. In order to investigate the effect of short-term withdrawal of gonadotrophin support in the luteal phase, the pulsatile infusion was stopped 3 d after ovulation and restarted 48 h later. After stopping the pump gonadotrophin and progesterone concentrations fell rapidly to very low levels, but when the infusion was restarted progesterone concentrations returned to normal mid-luteal values. Menstruation occurred 14 d after the LH surge. We conclude that normal progesterone secretion by the corpus luteum can be restored after temporary withdrawal of gonadotrophin support.
Polson
D W
DW
Department of Obstetrics and Gynaecology, St Mary's Hospital Medical School, London.
Sagle
M
M
Mason
H D
HD
Kiddy
D
D
Franks
S
S
D000568:Amenorrhea / Q000188:drug therapy*; D001835:Body Weight; D003338:Corpus Luteum / Q000502:physiology*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D008183:Luteal Phase / Q000187:drug effects; D007986:Luteinizing Hormone / Q000097:blood; D010906:Pituitary Hormone-Releasing Hormones / Q000627:therapeutic use*; D011374:Progesterone / Q000097:blood
D010906:Pituitary Hormone-Releasing Hormones; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone