[The role of DNA breaks in the regulation of cell proliferation, differentiation and aging].
The published and author's data on the involvement of DNA breaks in cell proliferation, differentiation and senescence are reviewed. During senescence, exogenous unrepaired DNA breaks are irreversibly accumulated. During differentiation, DNA breaks are also accumulated, but against the background of active reparation processes in the cell on the principle of a dynamic equilibrium between DNA breakage and reparation. When modelling the state of cell quiescence, both types of DNA breaks may take place. It is suggested that DNA breakage in the replicative complex is specific for the state of quiescence.
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D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002470:Cell Survival; D004249:DNA Damage; D004260:DNA Repair; D005786:Gene Expression Regulation; D006801:Humans
Rol' razryvov DNK v reguliatsii protsessov kletochnoĭ proliferatsii, differentsirovki i stareniia.