title: Comparison of adjuvanticity and autoantibody inducing capacity of endotoxin and radio-detoxified endotoxin in mice.
abstract: Endotoxin (LPS) and radio-detoxified endotoxin (RD-LPS: 150 kGy 60Co-gamma irradiated) preparations were compared in mice (C57Bl X CBA: F1/Rapo) for capacity to enhance the immune response against sheep red blood cells and to induce the production of antibody against autologous (bromelain-treated) erythrocytes. As RD-LPS retains its capacity to stimulate immune response against heterologous antigen, it may be used as an immuno-adjuvant. The LPS preparation gave rise to a significant increase of autoreactive cells. However, RD-LPS activated the autoantibody forming cells only to a very small degree.
authors.forename: V B
authors.initials: VB
authors.lastname: Klimovich
authors.forename: M P
authors.initials: MP
authors.lastname: Samoilovich
authors.forename: G N
authors.initials: GN
authors.lastname: Denisova
authors.forename: N S
authors.initials: NS
authors.lastname: Sirota
authors.forename: T S
authors.initials: TS
authors.lastname: Schuls
authors.forename: V I
authors.initials: VI
authors.lastname: Zeludov
authors.forename: L
authors.initials: L
authors.lastname: Bertók
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D004731:Endotoxins / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D004926:Escherichia coli; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male; D051379:Mice
chemical_list: D000276:Adjuvants, Immunologic; D001323:Autoantibodies; D004731:Endotoxins; D008070:Lipopolysaccharides