Chromosome anomalies as predictors of recurrence risk for spontaneous abortion.
Reproductive histories and chromosomes of spontaneous abortions were studied by segregation analysis in 1890 sibships ascertained through a cytogenetically studied abortion. Normal karyotypes are associated with recurrent abortion. Among abnormal karyotypes, trisomy has an elevated recurrence risk even after adjustment through a liability indicator for maternal age. Possible mechanisms and conflicting evidence in the literature on trisomy are discussed. None of these differences in recurrence risk is large enough to play a significant numerical role in genetic counseling.
Morton
N E
NE
Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Chiu
D
D
Holland
C
C
Jacobs
P A
PA
Pettay
D
D
D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations / Q000453:epidemiology*; D025063:Chromosome Disorders; D005260:Female; D005787:Gene Frequency; D005817:Genetic Counseling; D006801:Humans; D007621:Karyotyping; D011237:Predictive Value of Tests; D011247:Pregnancy; D012008:Recurrence; D012306:Risk; D012984:Software