Peripheral blood lymphocyte subpopulations after splenectomy for trauma.
Absolute and percent numbers of peripheral blood lymphocyte (PBL) subpopulations were evaluated using monoclonal antibodies in 20 subjects splenectomised for trauma. A significant increase was observed in the absolute counts of total PBL, B, null and Leu 7+ cells and in the percent counts of null and Leu 7+ lymphocytes. The percent numbers of OKT11+, OKT4+ and OKT8+ lymphocytes were significantly reduced, but the OKT4+/OKT8+ ratio was not statistically different from normal controls. The increase in B and killer/natural killer cells may provide a compensatory mechanism responsible for surveillance against infections and tumors in splenectomised patients, despite the numerous humoral and cellular abnormalities they commonly display.
Chelazzi
G
G
Divisione di Medicina Generale, Ospedale F. Del Ponte, U.S.S.L. 3 Varese, Italy.
Senaldi
G
G
Pinotti
G
G
Nicora
C
C
Rossi
D
D
Mondelli
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D005455:Fluorescent Antibody Technique; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D007958:Leukocyte Count; D008214:Lymphocytes / Q000145:classification* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000293:injuries; D013156:Splenectomy / Q000009:adverse effects; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal