Favorable cardiovascular effects of theophylline in COPD.
Theophylline has been utilized widely as a bronchodilator. However, recent studies have shown the potential for administering this drug to enhance cardiovascular performance in patients with chronic obstructive pulmonary disease (COPD). Administered to COPD patients orally as a sustained-action preparation or intravenously as aminophylline, theophylline enhances both right and left heart systolic pump function and lowers both pulmonary artery pressure and pulmonary vascular resistance. These favorable cardiovascular actions suggest an additional use for theophylline in COPD beyond its effects as a bronchodilator.
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D000284:Administration, Oral; D000628:Aminophylline / Q000008:administration & dosage / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D003692:Delayed-Action Preparations; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D009200:Myocardial Contraction / Q000187:drug effects; D011660:Pulmonary Heart Disease / Q000209:etiology / Q000503:physiopathology; D013806:Theophylline / Q000097:blood / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D003692:Delayed-Action Preparations; D000628:Aminophylline; D013806:Theophylline