title: Mutagenicity tests of cashewnut shell liquid, rice-bran oil and other vegetable oils using the Salmonella typhimurium/microsome system.
abstract: In view of the shortage of edible oils in India, nutritional and toxicological evaluations have been carried out on some unconventional oils to determine whether they might be safe for human consumption. As part of these evaluations, eight unconventional oils were tested by the Ames mutagenicity assay, using Salmonella typhimurium strains TA98 and TA100 with and without metabolic activation with S-9 mix prepared from the livers of rats pretreated with sodium phenobarbitone or Aroclor 1254. Of the oils tested, metsa oil (Hibiscus sabdariffa) and cashewnut shell liquid were mutagenic with and without metabolic activation with S-9 of either source. No mutagenic activity (with or without S-9 of either source) was observed with any of the other oils tested (rice-bran oil, Cleome viscosa oil, mango-kernel oil, mahua oil, kapok oil and neem oil).
authors.affiliation: National Institute of Nutrition, Indian Council of Medical Research, Jamai-Osmania.
authors.forename: K
authors.initials: K
authors.lastname: Polasa
authors.forename: C
authors.initials: C
authors.lastname: Rukmini
mesh_terms: D000818:Animals; D001711:Biotransformation; D005227:Fatty Acids / Q000032:analysis; D008862:Microsomes, Liver / Q000378:metabolism; D009754:Nuts; D009821:Oils / Q000032:analysis / Q000633:toxicity*; D012275:Oryza; D010938:Plant Oils / Q000032:analysis / Q000633:toxicity; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D005227:Fatty Acids; D009821:Oils; D010938:Plant Oils