Renal autotransplantation and extracorporeal reconstruction for complicated benign and malignant diseases of the urinary tract.
Renal autotransplantation was performed in five patients and extracorporeal vascular reconstruction was required in two of these cases. One had a carcinoma of the mid-ureter with a solitary kidney. Two patients had ureteral injury. One was iatrogenic from a prior operation, and the other had intrinsic ureteral disease secondary to schistosomiasis. The fourth patient had renovascular hypertension with disease extension into the interlobar renal arteries and a single kidney. The final patient had a large, renal arteriovenous malformation and polycystic kidneys. All have functioning grafts at follow-up ranging from 10 to 36 months. There is no evidence of tumor recurrence after 30 months in the patient with ureteral malignancy. The patient with renovascular hypertension has adequate blood pressure control with medication 12 months after surgery. His creatinine which had risen in the post-operative period to 4.2 mg/dl, has returned to its pre-operative valve of 1.8 mg/dl. None of the other four patients had any post-operative decline in renal function. These cases illustrate that the technique of nephrectomy, extracorporeal surgery, and renal autotransplantation can be applied to a variety of benign and malignant diseases of the kidney and ureter not amenable to conventional in-situ correction, thus allowing maximal preservation of renal parenchyma. We also have demonstrated that the procedure can be successfully performed in the presence of significant infectious risk (Case 2: indwelling nephrostomy), and retroperitoneal infection (Case 3: schistosomiasis). We feel that this procedure is currently underutilized.(ABSTRACT TRUNCATED AT 250 WORDS)
Radomski
J S
JS
Jarrell
B E
BE
Carabasi
R A
RA
Yang
S L
SL
D000328:Adult; D001165:Arteriovenous Malformations / Q000000981:diagnostic imaging / Q000601:surgery; D002295:Carcinoma, Transitional Cell / Q000601:surgery; D005260:Female; D006801:Humans; D007668:Kidney / Q000098:blood supply; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D007690:Polycystic Kidney Diseases / Q000601:surgery; D011859:Radiography; D012078:Renal Artery Obstruction / Q000601:surgery; D012552:Schistosomiasis / Q000150:complications; D014182:Transplantation, Autologous / Q000379:methods*; D014513:Ureter / Q000293:injuries; D014516:Ureteral Neoplasms / Q000601:surgery