title: Antibiotic prophylaxis with cefuroxime in arthroplasty of the knee.
abstract: A randomised prospective trial was undertaken of antibiotic prophylaxis given at various intervals before inflation of the tourniquet for arthroplasty of the knee. Cefuroxime assays of bone and subcutaneous fat from samples collected throughout the operation demonstrated that an interval of 10 minutes was necessary to obtain adequate prophylaxis. Improvement in the timing of antibiotic prophylaxis may result in a reduction in the incidence of infection.
authors.affiliation: Nuffield Orthopaedic Centre, Oxford, England.
authors.forename: D P
authors.initials: DP
authors.lastname: Johnson
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism; D002444:Cefuroxime / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D007432:Intraoperative Period; D007720:Knee Prosthesis; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000517:prevention & control; D013997:Time Factors; D014111:Tourniquets
chemical_list: D002511:Cephalosporins; D002444:Cefuroxime