title: Thrombosis in unstable angina: angiographic aspects.
abstract: Angiographic studies in patients with unstable angina indicate that intracoronary thrombus is present in a substantial proportion of patients with unstable angina who have early angiography and that these patients often have distinctive coronary lesion morphology that may represent a marker for instability. These studies, in conjunction with recent histopathologic studies demonstrating plaque defects and overlying thrombosis in patients with unstable ischemia and sudden death, suggest a common mechanism for unstable angina and myocardial infarction and strongly support the rationale for antithrombotic therapy with heparin and with aspirin in the management of patients with unstable angina.
authors.forename: R B
authors.initials: RB
authors.lastname: Rehr
authors.forename: G
authors.initials: G
authors.lastname: DiSciascio
authors.forename: M J
authors.initials: MJ
authors.lastname: Cowley
mesh_terms: D000787:Angina Pectoris / Q000000981:diagnostic imaging*; D000789:Angina, Unstable / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D000792:Angiography; D001158:Arteries / Q000473:pathology; D001241:Aspirin / Q000627:therapeutic use; D003326:Coronary Circulation; D003327:Coronary Disease / Q000175:diagnosis / Q000473:pathology; D005069:Evaluation Studies as Topic; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D013927:Thrombosis / Q000000981:diagnostic imaging* / Q000503:physiopathology
chemical_list: D006493:Heparin; D001241:Aspirin