title: [Beta interferon therapy in hairy cell leukemia].
abstract: Eleven patients with histologically proven hairy-cell leukemia were treated for 2 to 6 months with a natural beta-interferon (beta-IFN) preparation (3 X 4 million units week i.v.). Three of the eight evaluable patients experienced a partial response, two a minor response, and three no improvement. A reduction of the hairy-cell infiltration of the bone marrow was observed in one patient. Typical IFN side-effects with flu-like symptoms were noted. These results demonstrate that IFN-beta has some clinical efficacy in hairy-cell leukemia.
authors.forename: P
authors.initials: P
authors.lastname: von Wussow
authors.forename: J
authors.initials: J
authors.lastname: Dühlmann
authors.forename: T
authors.initials: T
authors.lastname: Grethlein
authors.forename: W D
authors.initials: WD
authors.lastname: Hirschmann
authors.forename: E
authors.initials: E
authors.lastname: Hügl
authors.forename: O
authors.initials: O
authors.lastname: Koch
authors.forename: W R
authors.initials: WR
authors.lastname: Martin
authors.forename: H W
authors.initials: HW
authors.lastname: Pees
authors.forename: W
authors.initials: W
authors.lastname: Urbanitz
authors.forename: M
authors.initials: M
authors.lastname: Freund
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects / Q000627:therapeutic use*; D007943:Leukemia, Hairy Cell / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction
chemical_list: D007370:Interferon Type I
vernacular_title: IFN-beta-Therapie bei der Haarzelleukämie.