NAD-linked aldehyde dehydrogenase for aerobic utilization of L-fucose and L-rhamnose by Escherichia coli.
Mutant analysis revealed that complete utilization of L-fucose and L-rhamnose by Escherichia coli requires the activity of a common NAD-linked aldehyde dehydrogenase which converts L-lactaldehyde to L-lactate. Mutations affecting this activity mapped to the ald locus at min 31, well apart from the fuc genes (min 60) encoding the trunk pathway for L-fucose dissimilation (as well as L-1,2-propanediol oxidoreductase) and the rha genes (min 88) encoding the trunk pathway for L-rhamnose dissimilation. Mutants that grow on L-1,2-propanediol as a carbon and energy source also depend on the ald gene product for the conversion of L-lactaldehyde to L-lactate.
Chen
Y M
YM
Zhu
Y
Y
Lin
E C
EC
D000444:Aldehyde Dehydrogenase / Q000235:genetics / Q000378:metabolism*; D002874:Chromosome Mapping; D004794:Enzyme Repression; D004926:Escherichia coli / Q000378:metabolism*; D005643:Fucose / Q000378:metabolism*; D005786:Gene Expression Regulation; D005798:Genes, Bacterial; D005947:Glucose / Q000378:metabolism; D012210:Rhamnose / Q000378:metabolism*; D014994:Xylose / Q000378:metabolism
D005643:Fucose; D014994:Xylose; D000444:Aldehyde Dehydrogenase; D005947:Glucose; D012210:Rhamnose