title: Physiology of hemostasis and its relationship to cardiovascular disease.
abstract: Our original understanding of coagulation was too simple. The waterfall or cascade system made sense but never gave clues either to points for control of the reaction or to areas to inhibit or reverse clotting. We now know critical points for control and reversal of hemostasis. By understanding more modern physiology, one is better able to design rational treatment programs to negate unwanted thrombosis. This chapter gives the reader a physiologic foundation to underscore the subsequent chapters.
authors.forename: R
authors.initials: R
authors.lastname: Lottenberg
authors.forename: C S
authors.initials: CS
authors.lastname: Kitchens
mesh_terms: D001777:Blood Coagulation; D001792:Blood Platelets / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000503:physiopathology; D004727:Endothelium / Q000502:physiology; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D013917:Thrombin / Q000378:metabolism; D013927:Thrombosis / Q000209:etiology
chemical_list: D013917:Thrombin