title: Chloroquine resistance in Plasmodium falciparum in Natal.
abstract: Out of 110 cultures of Plasmodium falciparum obtained from infected patients in Natal 18 were found to be resistant to chloroquine by in vitro tests: 2 cultures showed schizont development in wells containing 24 pmol chloroquine; in 16 schizont development was present in culture wells containing 48 pmol chloroquine. Seventy-two patients with P. falciparum malaria who apparently did not respond to adequate oral chloroquine therapy were investigated. All responded to one or more treatments with pyrimethamine/sulphadoxine (Fansidar; Roche). It would seem that all the patients were infected in areas not controlled by the South African health authorities.
authors.affiliation: Department of National Health and Population Development, University of Natal, Durban.
authors.forename: J M
authors.initials: JM
authors.lastname: Herbst
authors.forename: L A
authors.initials: LA
authors.lastname: Taylor
authors.forename: S M
authors.initials: SM
authors.lastname: Joubert
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology / Q000627:therapeutic use*; D004351:Drug Resistance; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D010963:Plasmodium falciparum / Q000187:drug effects*; D013019:South Africa
chemical_list: D002738:Chloroquine