[Allogeneic transplantation of the small intestine--animal experiments and a clinical retrospect].
Allogenic transplantation of small intestine has proved to be an alternative therapy for complex failure of intestinal functions. Attempts in that direction had been made over many years, but impressive were obtained only under conditions of modern immunosuppressive therapy. Hence, wider clinical application is imminent at an international scale. Reference is made in this paper to the authors' own experience obtained from mongrel dogs for an account of indications, surgical technique for collection of intestine and transplantation, perfusion and preservation of the donor organ as well as of various pathophysiological, functional, and immunological aspects. Results obtained at different centres are discussed, with reference being made to individual cases and clinical findings recorded from them. The survival rate of animals which have undergone transplantation of the small intestine provides evidence for the possibility of such organ transplantation and means a challenge to all involved in conventional intestinal surgery and modern medical transplantation.
Luther
B
B
Wolff
H
H
David
H
H
Buchali
K
K
Pahlig
H
H
D000328:Adult; D000818:Animals; D002648:Child; D004285:Dogs; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007082:Ileum / Q000637:transplantation*; D007165:Immunosuppression Therapy; D007583:Jejunum / Q000637:transplantation*; D008286:Malabsorption Syndromes / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation; D011183:Postoperative Complications / Q000209:etiology; D012778:Short Bowel Syndrome / Q000601:surgery*; D013536:Suture Techniques
Die allogene Dünndarmtransplantation--Tierversuche und klinischer Rückblick.