Antimutagenic effect of p-aminobenzoic acid on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine in Salmonella typhimurium.
p-Aminobenzoic acid (PABA) exhibited antimutagenic activity toward N-methyl-N'-nitro-N-nitrosoguanidine(MNNG)-induced mutagenicity in the Ames assay in Salmonella typhimurium. The antimutagenic effects were associated with an increased rate of decomposition of MNNG in the presence of PABA. The participation of other mechanisms, such as the alteration of cellular processes by PABA, however, cannot be excluded.
Gichner
T
T
Institute of Experimental Botany, Praha, Czechoslovakia.
Véleminský
J
J
Rapoport
I A
IA
Vasilieva
S V
SV
D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D062365:Aminobenzoates / Q000494:pharmacology*; D008769:Methylnitronitrosoguanidine / Q000037:antagonists & inhibitors*; D009152:Mutagenicity Tests; D012486:Salmonella typhimurium / Q000187:drug effects*
D062365:Aminobenzoates; D008769:Methylnitronitrosoguanidine; D010129:4-Aminobenzoic Acid