Inhibitory effect of a protease inhibitor, leupeptin, on the development of influenza pneumonia, mediated by concomitant bacteria.
The protease inhibitor leupeptin prevented multiple step replication of an influenza virus (A/swine/1976/31, H1N1) mediated by staphylococcal proteases. It also suppressed virus replication and development of fatal pneumonia in mice co-infected with the virus and Staphylococcus aureus.
Tashiro
M
M
Klenk
H D
HD
Rott
R
R
D000818:Animals; D010450:Endopeptidases / Q000378:metabolism; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral / Q000378:metabolism*; D009980:Influenza A virus / Q000502:physiology*; D007976:Leupeptins / Q000494:pharmacology*; D008666:Metalloendopeptidases; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology*; D009976:Orthomyxoviridae Infections / Q000150:complications*; D011023:Pneumonia, Staphylococcal / Q000209:etiology / Q000517:prevention & control*; D011480:Protease Inhibitors; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D013211:Staphylococcus aureus / Q000201:enzymology; D014779:Virus Replication / Q000187:drug effects
D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral; D007976:Leupeptins; D009842:Oligopeptides; D011480:Protease Inhibitors; D010450:Endopeptidases; D008666:Metalloendopeptidases; C022653:auR protein, Staphylococcus aureus; C032854:leupeptin