Influence of glucose, alcohol and glycerol on galactose tolerance in man.
Six volunteers were given 0.5 g galactose/kg body weight alone (A) or with 0.5 g glucose/kg (B) or with 0.5 g glycerol/kg body weight (C). Meals A and B were also given 15 min after ingestion of 300 mg ethanol/kg body weight. Glycerol did not influence the serum galactose response to galactose. Glucose reduced the serum galactose response as was expected. Administration of alcohol prior to a galactose test meal increased the mean area under the serum galactose response curve (p less than 0.01); when glucose was given with galactose after alcohol ingestion, the serum galactose response was significantly reduced (p less than 0.01) when compared to the serum galactose response to galactose after alcohol, but remained higher than after the galactose and glucose test meal. Glucose, therefore, can reduce the effect of alcohol on galactose levels but alcohol can abolish the effect of glucose on galactose metabolism.
Williams
C A
CA
Department of Biochemistry, University of Surrey, Guildford, UK.
D000328:Adult; D001786:Blood Glucose; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005690:Galactose / Q000378:metabolism*; D005990:Glycerol / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D008297:Male
D001786:Blood Glucose; D007328:Insulin; D000431:Ethanol; D005990:Glycerol; D005690:Galactose