[Determination of non-organ specific autoantibodies. Their relevance for the differentiation of autoimmune diseases].
The determination of non-organ-specific autoantibodies is a major tool in the serological diagnosis of rheumatic disorders. Antinuclear antibodies (ANA) are routinely determined by indirect immunofluorescence (IFL) testing on cryostat sections, but the use of cultured cell lines now allows to detect new antibody specificities that are obscured on tissue sections. Titres and IFL patterns of antibodies add further information to the interpretation of results. Homogeneous or perimembranous patterns point to systemic lupus erythematosus (SLE) which is better characterized by the presence of antibodies to double-stranded DNA or to the Smith-antigen (Sm-antigen) detected by other methods. Antibodies to extractable nuclear antigens (ENA) are strongly correlated with connective tissue disease, the main representatives of which may now be identified serologically by the presence of marker anti-ENA antibodies.
Blaschek
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MA
D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D006801:Humans
D001323:Autoantibodies
Bestimmung nicht-organspezifischer Autoantikörper. Ihre Relevanz für die Differenzierung von Autoimmunerkrankungen.