A comparative trial of a new antidepressant, fluoxetine.
This clinical trial of a new antidepressant, fluoxetine, shows it to be as effective as a standard tricyclic drug, imipramine. It is effective as a single daily dose and is free of any significant side-effects. It is less sedative and appears to cause fewer problems of weight increase. The three scales used to assess efficacy showed a very positive correlation.
Levine
S
S
Oldham and District General Hospital.
Deo
R
R
Mahadevan
K
K
D000328:Adult; D000368:Aged; D001835:Body Weight; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011437:Propylamines / Q000627:therapeutic use*; D014202:Tremor / Q000139:chemically induced
D011437:Propylamines; D005473:Fluoxetine; D007099:Imipramine