Inhibition of growth and swarming of Proteus mirabilis and Proteus vulgaris by triclosan.
The MICs of triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) and the effect on swarming were determined for 35 isolates of Proteus mirabilis and 7 isolates of P. vulgaris of animal origin. Both species were susceptible to the antimicrobial agent, and growth of all but one isolate was inhibited by less than 1 microgram/ml in broth and on agar without blood. Swarming was inhibited at triclosan concentrations two- to fourfold less than the MICs. Higher concentrations were required with blood agar than with plain agar for inhibition of growth and swarming.
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D002465:Cell Movement / Q000187:drug effects; D003470:Culture Media; D010647:Phenyl Ethers / Q000494:pharmacology*; D011513:Proteus mirabilis / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D011514:Proteus vulgaris / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D014260:Triclosan / Q000494:pharmacology*
D003470:Culture Media; D010647:Phenyl Ethers; D014260:Triclosan