title: Role of the thymus in histiocytosis-X.
abstract: An increasing number of reports have demonstrated that patients with histiocytosis-X show significant morphologic changes in the thymus gland. The changes include severe dysplasia, dysmorphia, and severe nonspecific involution. These findings are present in all children with histiocytosis-X who die, but can be found even when the disease is limited to one bone and is not fatal.
authors.affiliation: Department of Laboratory Medicine, Children's Hospital, Columbus, Ohio.
authors.forename: W A
authors.initials: WA
authors.lastname: Newton
authors.forename: A B
authors.initials: AB
authors.lastname: Hamoudi
authors.forename: B T
authors.initials: BT
authors.lastname: Shannon
mesh_terms: D000367:Age Factors; D006646:Histiocytosis, Langerhans-Cell / Q000276:immunology / Q000473:pathology*; D006801:Humans; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology*