title: Interaction between Candida agglutinins and antifungal agents.
abstract: Antifungal agents alter the function and morphology of Candida cell membranes and cell walls. We observed that brief (30 minute) exposure to either amphotericin B or clotrimazole inhibited the agglutination of Candida blastoconidia by murine bronchoalveolar lavage fluid. This inhibition required continuous drug presence. Neither amphotericin nor clotrimazole inhibited Candida agglutination by concanavalin A or pooled human serum. These results demonstrate that antifungal drugs can produce rapid changes in the surface characteristics of some fungi.
authors.forename: J C
authors.initials: JC
authors.lastname: Lutz
authors.forename: K M
authors.initials: KM
authors.lastname: Nugent
mesh_terms: D000371:Agglutination / Q000187:drug effects; D000373:Agglutinins / Q000378:metabolism*; D000666:Amphotericin B / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D002176:Candida albicans / Q000187:drug effects* / Q000276:immunology / Q000648:ultrastructure; D002462:Cell Membrane / Q000187:drug effects; D002473:Cell Wall / Q000187:drug effects; D003022:Clotrimazole / Q000378:metabolism / Q000494:pharmacology*; D003208:Concanavalin A / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology*; D051379:Mice
chemical_list: D000373:Agglutinins; D007093:Imidazoles; D003208:Concanavalin A; D000666:Amphotericin B; D003022:Clotrimazole