Effect of cholinesterase inhibitors on acetylcholine and insulin induced glucose uptake and certain hepatic enzymes in pigeon liver: an in vitro study.
Insulin and acetylcholine (ACh) are both known to promote glucose uptake by liver of birds. Acetylcholine induced glucose uptake can be predictably potentiated by inhibiting acetylcholinesterase activity. Monocrotophos, acothione (organophosphorus compound) and prostigmine are known inhibitors of acetylcholinesterase (AChE). In the present study the action of these three inhibitors of AChE alone as well as in combination with insulin and acetylcholine on in vitro glucose uptake by pigeon liver slices was investigated. Both organophorus compounds potentiated the action of insulin as well as acetycholine mediated glucose uptake by liver slices while prostigmine had inhibitory influence. The three compounds also induced alterations in enzyme activities in the liver slices. These results are discussed in detail in the text.
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Department of Zoology, Faculty of Science, M.S. University of Baroda.
Mehan
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D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D010856:Columbidae; D005947:Glucose / Q000378:metabolism*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism
D002800:Cholinesterase Inhibitors; D007328:Insulin; D008112:Liver Glycogen; D005947:Glucose; D000109:Acetylcholine