Regional chromosomal assignment of human renin gene to 1q12----qter and use in linkage studies in Charcot-Marie-Tooth disease.
The gene for renin, previously mapped to human chromosome 1, was further localized to 1q12----qter using human-mouse somatic cell hybrid DNAs. The renin DNA probe used (lambda HR5) could detect a HindIII restriction fragment length polymorphism. When used in studies of 12 informative families, no linkage could be found between the renin gene and Charcot-Marie-Tooth disease. Furthermore, an association of any renin allele with hypertension was not apparent.
Griffiths
L R
LR
Department of Medicine, University of Sydney, Australia.
Nicholson
G A
GA
Ross
D A
DA
Zwi
M B
MB
McLeod
J G
JG
Mohandas
T
T
Morris
B J
BJ
D000818:Animals; D002607:Charcot-Marie-Tooth Disease / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology; D008297:Male; D051379:Mice; D009134:Muscular Atrophy, Spinal / Q000235:genetics*; D010375:Pedigree; D012083:Renin / Q000235:genetics*
D012083:Renin