[Structural proteins of the cytoskeleton as markers for determining tumor histogenesis].
The data of literature about the structure of cytoskeleton proteins in the normal and malignant cells are analyzed. The possibilities of using a specific polyclonal serum and a monoclonal antibody for a more precise ascertainment of the origin and diagnostic of tumours are discussed. The intermediate and active filaments may be used as a new class of histochemical markers. Laminin, the protein of basement membranes, probably, plays an important role in metastatic spreading.
Chernovskaia
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D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D003598:Cytoskeletal Proteins; D006801:Humans; D007381:Intermediate Filament Proteins
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D003598:Cytoskeletal Proteins; D007381:Intermediate Filament Proteins
Strukturnye belki tsitoskeleta kak markery dlia opredeleniia gistogeneza opukholeĭ.