Canine unilateral lung transplantation: effect of ciclosporin A on the frequency of donor-lytic lymphocytes.
Limiting dilution analysis showed that the frequency of precursor donor-lytic cytolytic lymphocytes increased dramatically within the leucocyte population recovered by broncho-alveolar lavage in dogs after unilateral lung transplantation. The increases for animals experiencing acute pulmonary rejection (11.5-24.8 times pre-operative level) and for those receiving long-term ciclosporin A therapy (5.4-17.6 times pre-operative level) were similar. Therefore, it appears that ciclosporin A does not prevent the sequestration of precursor donor-lytic cytotoxic cells within lung allograft tissue.
Kirby
J A
JA
Reader
J A
JA
Corbishley
C M
CM
Pepper
J R
JR
Hudson
L
L
D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D007249:Inflammation; D007376:Interleukin-2 / Q000096:biosynthesis; D008168:Lung / Q000276:immunology / Q000473:pathology; D016040:Lung Transplantation; D008297:Male; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000276:immunology*; D014184:Transplantation, Homologous
D003524:Cyclosporins; D007376:Interleukin-2