Early indicators of nephrotoxicity: comparison of two antibiotics.
The aim of the study was the evaluation of the clinical efficacy and the kidney tolerance of ceftazidime in comparison with netilmicin in pediatric patients. Forty subjects, ranging from six months to ten years of age were randomly allocated in two groups and treated either with ceftazidime (80-100 mg/kg/day) or netilmicin (6 mg/kg/day). A control group of twenty subjects was selected in order to establish the normal values of beta 2-microglobulin and urinary enzymes excretion. beta 2-microglobulin, enzymuria, cylindruria and urinary osmolability were estimated, as well as hematological parameters. Ceftazidime was as efficacious as netilmicin in the clinical outcome and in addition it did not cause any pathological change in early markers of tubular damage.
Cecconi
M
M
Institute of Clinical Pediatrics, University of Ancona, Italy.
Manfredi
R
R
Cecarini
L
L
Giorgi
P L
PL
Benedetti
M
M
Accorroni
V
V
D002442:Ceftazidime / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000139:chemically induced* / Q000652:urine; D008111:Liver Function Tests; D009428:Netilmicin / Q000009:adverse effects* / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy; D001613:beta 2-Microglobulin / Q000378:metabolism
D001613:beta 2-Microglobulin; D009428:Netilmicin; D002442:Ceftazidime