title: Does colchicine work? The results of the first controlled study in acute gout.
abstract: We have performed the first controlled study of colchicine in acute gout, to determine its efficacy and toxicity, and to define the natural history of acute gout. Two-thirds of colchicine-treated patients improved after 48 hours, but only one-third of the patients receiving placebo demonstrated similar improvement. The colchicine-treated patients responded earlier; significant differences from placebo were shown after 18-30 hours. All patients given colchicine developed diarrhea after a median time of 24 hours (mean dose of colchicine 6.7 mg). This side effect occurred before relief of pain in most patients.
authors.affiliation: Department of Medicine, Flinders University of South Australia.
authors.forename: M J
authors.initials: MJ
authors.lastname: Ahern
authors.forename: C
authors.initials: C
authors.lastname: Reid
authors.forename: T P
authors.initials: TP
authors.lastname: Gordon
authors.forename: M
authors.initials: M
authors.lastname: McCredie
authors.forename: P M
authors.initials: PM
authors.lastname: Brooks
authors.forename: M
authors.initials: M
authors.lastname: Jones
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002986:Clinical Trials as Topic; D003078:Colchicine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006073:Gout / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement
chemical_list: D003078:Colchicine