title: [Mutants of Saccharomyces cerevisiae characterized by increased level of induced mutagenesis. I. Isolation and preliminary characterization of mutants].
abstract: 6 mutants with enhanced nitrous acid-induced reversibility of the ade2-42 allele were isolated and designated hm (high mutagenesis). Apart from sensitivity to the mutagenic exposure to nitrous acid, hm mutants were also spontaneous mutators and hypermutable under the action of UV-light and 6-N-hydroxyaminopurine. All these effects were detected not only when analysing reversibility of the ade2-42 allele, but also when scoring forward mutations in the ADE1, ADF2 genes. Gamma-mutagenesis, however, was not affected by hm mutations.
authors.forename: E L
authors.initials: EL
authors.lastname: Ivanov
authors.forename: S V
authors.initials: SV
authors.lastname: Koval'tsova
authors.forename: V G
authors.initials: VG
authors.lastname: Korolev
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D005800:Genes, Fungal; D009154:Mutation; D009608:Nitrous Acid / Q000633:toxicity; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D009608:Nitrous Acid
vernacular_title: Mutanty drozhzheĭ Saccharomyces cerevisiae, kharakterizuiushchiesia povyshennym indutsirovannym mutagenezom. Soobshchenie I. Vydelenie mutantov i ikh predvaritel'noe izuchenie.