Effects of feeding lactobacillus GG on lethal irradiation in mice.
Mice exposed to 1400 rads of total body irradiation experienced 80%-100% mortality in 2 wk. Bacteremia was demonstrated in all dead animals. Feeding Lactobacillus GG strain reduced Pseudomonas bacteremia and prolonged survival time in animals colonized with this organism. In animals not colonized with Pseudomonas, feeding Lactobacillus GG also produced some reduction in early deaths, and there was less Gram-negative bacteremia in these animals compared with controls.
Dong
M Y
MY
Department of Community Health, Tufts University School of Medicine Boston, MA 02111.
Chang
T W
TW
Gorbach
S L
SL
D000818:Animals; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D007778:Lactobacillus / Q000254:growth & development* / Q000302:isolation & purification; D051379:Mice; D011552:Pseudomonas Infections / Q000503:physiopathology; D011835:Radiation Protection; D018805:Sepsis / Q000503:physiopathology*; D014916:Whole-Body Irradiation