Summarizing methacholine bronchoprovocation data in epidemiological surveys.
We have performed bronchoprovocation tests with methacholine in 41 patients with asthma due to Western red cedar dust and in 56 office-workers without known respiratory illness. Our purpose was to define a summary statistic for useful bronchial hyperresponsiveness in epidemiologic surveys. We found a significant linear relationship between the concentration of methacholine and the FEV1 response. We noted, in addition, a positive relation between the rate of the FEV1 response per concentration and the level of FEV1. We conclude that a linear dose-response slope, which can be calculated for each individual, provides a comprehensive summary of methacholine bronchoprovocation tests and is useful in epidemiologic surveys.
Enarson
D A
DA
Respiratory Division, Vancouver General Hospital, University of British Columbia, Canada.
Schulzer
M
M
Vedal
S
S
Chan-Yeung
M
M
D000328:Adult; D001249:Asthma / Q000503:physiopathology*; D001985:Bronchial Provocation Tests / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004812:Epidemiologic Methods; D006801:Humans; D008448:Maximal Expiratory Flow Rate; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000494:pharmacology*; D008875:Middle Aged; D008954:Models, Biological
D008688:Methacholine Compounds; D016210:Methacholine Chloride