title: The pharmacologic basis of diuretic therapy in the newborn.
abstract: Effective use of diuretics in critically ill newborns requires an understanding of the ontogeny of renal function, a knowledge of the pathophysiology of the patient's disease, an expectation of the pharmacodynamics of the several classes of diuretics, and an appreciation of the kinetics and toxicities of the selected agents. Unfortunately, the number and scope of clinical pharmacologic studies of diuretics in critically ill newborns are inadequate for optimal therapy with most of these drugs.
authors.affiliation: Division of Pediatric Critical Care, University of Minnesota, Minneapolis.
authors.forename: T P
authors.initials: TP
authors.lastname: Green
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000188:drug therapy; D004232:Diuretics / Q000494:pharmacology* / Q000627:therapeutic use; D005665:Furosemide / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D007231:Infant, Newborn; D011654:Pulmonary Edema / Q000188:drug therapy / Q000209:etiology; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications; D014883:Water-Electrolyte Imbalance / Q000188:drug therapy / Q000209:etiology
chemical_list: D004232:Diuretics; D005665:Furosemide