[Clinical study and effect of nitroxoline on fecal flora in children].
Twelve children (mean age: 4) are treated in practice office with nitroxoline (200 mg/kg/24 h) during 10 days for urinary tract infection. A study on the effect of nitroxoline against the fecal flora is undertaken in a group of 21 children who receive nitroxoline during 4 days or a long period. Bacteriological and clinical efficacy is checked when urinary concentrations of nitroxoline are greater than 16 mg/l. The results show 8 clinical and bacteriological success one true failure and 3 failure due to a non-compliance to the treatment. No qualitative and quantitative modification of the fecal flora is observed after treatment with nitroxoline.
Lambert-Zechovsky
N
N
Lévêque
B
B
Bingen
E
E
Pillion
G
G
Chapelle
J
J
Mathieu
H
H
D000293:Adolescent; D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009600:Nitroquinolines / Q000494:pharmacology*; D014552:Urinary Tract Infections / Q000188:drug therapy
D000892:Anti-Infective Agents, Urinary; D009600:Nitroquinolines; C005308:nitroxoline
Activité clinique et effet de la nitroxoline sur la flore fecale chez l'enfant.