Amino acid sequence of chicken liver cathepsin L.
The complete amino acid sequences of the heavy and light chains of chicken liver cathepsin L have been determined by automated gas-phase Edman degradation. The heavy and light chains contained 176 and 42 amino acid residues respectively. A glucosamine-based oligosaccharide group was attached to Asn-109 of the heavy chain. Chicken liver cathepsin L had high sequence homology with rat cathepsin H, but exhibited less similarity with rat cathepsin B. Comparisons of cathepsin L with plant cysteine proteinases, such as papain, actinidin and aleurain, reveal high degree of homology.
Wada
K
K
Takai
T
T
Tanabe
T
T
D000595:Amino Acid Sequence; D000818:Animals; D002268:Carboxypeptidases / Q000378:metabolism; D056668:Cathepsin L; D002403:Cathepsins / Q000032:analysis*; D002645:Chickens; D002851:Chromatography, High Pressure Liquid; D003546:Cysteine Endopeptidases; D010450:Endopeptidases / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D051379:Mice; D010449:Peptide Mapping; D051381:Rats; D012697:Serine Endopeptidases
D002268:Carboxypeptidases; D002403:Cathepsins; D010450:Endopeptidases; C022633:serine carboxypeptidase; C025097:Escherichia coli periplasmic proteinase; D012697:Serine Endopeptidases; D003546:Cysteine Endopeptidases; D056668:Cathepsin L; C534278:Ctsl protein, mouse; C534280:Ctsl protein, rat