title: Venocclusive disease of the liver after chemoradiotherapy and autologous bone marrow transplantation.
abstract: We determined the incidence of venocclusive disease of the liver (VOD) in 96 recipients of autologous bone marrow transplants (BMT) to be 9.4%, a figure less than that reported for allogeneic transplantation. The development of VOD was compared in a cohort of 21 autologous BMT recipients and in 56 randomly chosen, comparably conditioned, concurrent allogeneic BMT recipients. One of these 21 (4.8%) autologous recipients developed VOD, versus 14 of 56 (25%) allogeneic recipients (P less than 0.05). Logistic regression analysis confirmed pretransplant hepatocellular dysfunction as a risk factor for VOD, and suggested that the use of methotrexate and/or cyclosporine contributes to the development of VOD after chemoradiation therapy. However, a graft-versus-host reaction cannot be excluded as a cause of the higher incidence of VOD in allogeneic recipients.
authors.forename: F L
authors.initials: FL
authors.lastname: Dulley
authors.forename: E J
authors.initials: EJ
authors.lastname: Kanfer
authors.forename: F R
authors.initials: FR
authors.lastname: Appelbaum
authors.forename: D
authors.initials: D
authors.lastname: Amos
authors.forename: R S
authors.initials: RS
authors.lastname: Hill
authors.forename: C D
authors.initials: CD
authors.lastname: Buckner
authors.forename: H M
authors.initials: HM
authors.lastname: Shulman
authors.forename: G B
authors.initials: GB
authors.lastname: McDonald
authors.forename: E D
authors.initials: ED
authors.lastname: Thomas
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D001943:Breast Neoplasms / Q000628:therapy; D002648:Child; D005260:Female; D006504:Hepatic Veno-Occlusive Disease / Q000209:etiology*; D006801:Humans; D007938:Leukemia / Q000628:therapy; D008175:Lung Neoplasms / Q000628:therapy; D008223:Lymphoma / Q000628:therapy; D008297:Male; D012512:Sarcoma, Ewing / Q000628:therapy; D013724:Teratoma / Q000628:therapy; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous