The pathogenesis of rheumatoid arthritis. A critical assessment of the role of autologous stimulation in the perpetuation of rheumatoid synovitis.
Current models for rheumatoid arthritis emphasize the role of activated T cells and their products in the pathogenesis of synovitis. The data supporting this view are critically reviewed in this article and inconsistencies are discussed. To resolve these contradictions, the authors propose that rheumatoid synovitis represents a localized autologous mixed lymphocyte reaction.
Firestein
G S
GS
Department of Medicine, School of Medicine, San Diego, California.
Zvaifler
N J
NJ
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000276:immunology; D012217:Rheumatoid Factor / Q000276:immunology; D013585:Synovitis / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens; D008222:Lymphokines; D012217:Rheumatoid Factor