Role of the thymus in histiocytosis-X.
An increasing number of reports have demonstrated that patients with histiocytosis-X show significant morphologic changes in the thymus gland. The changes include severe dysplasia, dysmorphia, and severe nonspecific involution. These findings are present in all children with histiocytosis-X who die, but can be found even when the disease is limited to one bone and is not fatal.
Newton
W A
WA
Department of Laboratory Medicine, Children's Hospital, Columbus, Ohio.
Hamoudi
A B
AB
Shannon
B T
BT
D000367:Age Factors; D006646:Histiocytosis, Langerhans-Cell / Q000276:immunology / Q000473:pathology*; D006801:Humans; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology*