[Cytomorphological study of the action of ornidazole against Bacteroides fragilis].
The action of ornidazole on Bacteroides fragilis at the following concentrations, 4 MIC--MIC--MIC/2--MIC/4, is observed by electron microscopy, transmission and scanning, for 18 to 48 hours. The primary effect on ultrastructure was characterized by a distinct change in the morphology with filament formations and abnormal forms. Secondary effects were significant change in the distribution of ribosomes and abnormal cell division. No significant alterations in the peripheral cell wall were observed.
Attisso
M A
MA
Laboratoire de Bactériologie et Biologie cellulaire, Faculté de Pharmacie, Montpellier.
Dusart
G
G
Simeon De Buochberg
M
M
Zuccarelli
M
M
D001431:Bacteriological Techniques; D001441:Bacteroides fragilis / Q000187:drug effects* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D009593:Nitroimidazoles / Q000494:pharmacology*; D009950:Ornidazole / Q000494:pharmacology*
D009593:Nitroimidazoles; D009950:Ornidazole
Etude cyto-morphologique de l'action de l'ornidazole sur Bacteroides fragilis.