title: Glutathione and peroxide metabolism in malaria-parasitized erythrocytes.
abstract: The glutathione metabolism of Plasmodium falciparum, P. vinckei and P. berghei has been investigated. Human erythrocytes with low glutathione reductase and synthetase activity are still capable of harbouring P. falciparum. Both enzymes have been demonstrated in Plasmodium spp. Moreover, evidence is given for a selenium-independent glutathione peroxidase in malaria parasites.
authors.affiliation: Physiologisch-chemisches Institut der Universität, Tübingen, Federal Republic of Germany.
authors.forename: B
authors.initials: B
authors.lastname: Fritsch
authors.forename: A
authors.initials: A
authors.lastname: Dieckmann
authors.forename: B
authors.initials: B
authors.lastname: Menz
authors.forename: E
authors.initials: E
authors.lastname: Hempelmann
authors.forename: K G
authors.initials: KG
authors.lastname: Fritsch
authors.forename: G
authors.initials: G
authors.lastname: Fritsch
authors.forename: A
authors.initials: A
authors.lastname: Jung
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism / Q000469:parasitology*; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005981:Glutathione Synthase / Q000378:metabolism; D006801:Humans; D051379:Mice; D010084:Oxidation-Reduction; D010545:Peroxides / Q000378:metabolism*; D010961:Plasmodium / Q000201:enzymology / Q000378:metabolism*; D010962:Plasmodium berghei / Q000201:enzymology / Q000378:metabolism; D010963:Plasmodium falciparum / Q000201:enzymology / Q000378:metabolism; D012643:Selenium / Q000097:blood; D013379:Substrate Specificity
chemical_list: D010545:Peroxides; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005981:Glutathione Synthase; D005978:Glutathione; D012643:Selenium