title: Conservative treatment in the clinical stage T1N0 of breast cancer.
abstract: A 18-year experience with 643 cases operated for breast cancer is reported. 161 cases belonged to the clinical stage T1N0: 78 underwent modified radical mastectomy (group 1) and 83 underwent conservative surgery (group 2). Conservative treatment consisted in quadrantectomy and axillary dissection of 1st, 2nd and 3rd level with postoperative radiotherapy (5000 rad). Within the two groups the patient's characteristics were homogeneous with juxtaposable curves of overall and disease-free survival after modified radical mastectomy and after conservative surgery. In 15.38% of cases undergoing modified radical mastectomy and in 13.25% of cases undergoing quadrantectomy, histologic examination showed the presence of lymph node metastases (pT1N1) not identified at the clinical examination. The analysis of results showed that early neoplastic recurrence is almost exclusively limited to cases pN1, but the fall in the survival curve it similar in group 1 as well as in group 2. Therefore it should be understood that the prognostic risk is related to positive lymph nodes and not to the chosen treatment. Postoperative complications, irrelevant in group 1, tend to disappear in group 2. The cosmetic result after conservative surgery was excellent in 37.3%, satisfactory in 54.2% and poor in 8.4% of cases, respectively.
authors.affiliation: Divisione di Chirurgia Generale, Ospedali Riuniti di Pesaro.
authors.forename: R
authors.initials: R
authors.lastname: Giacchi
authors.forename: M
authors.initials: M
authors.lastname: Sebastiani
authors.forename: P
authors.initials: P
authors.lastname: Giorgini
authors.forename: F
authors.initials: F
authors.lastname: Lungarotti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications