Studies on a new formulation of ceftazidime--ceftazidime arginine--in patients with recurrent chest infections.
One hundred hospital patients with respiratory infections were treated with 1 or 2 g intramuscular injections of ceftazidime sodium or of a new formulation of ceftazidime with arginine three times daily. Clinical and microbiological assessments showed no significant differences in efficacy between the two preparations. Local pain necessitating lignocaine was noted in five of 49 evaluable patients given ceftazidime sodium (10.2%) but in none of the 50 receiving ceftazidime arginine. No other unwanted effects were recorded. The pharmacokinetic results after the 1 g injections showed slightly higher Cmax values with ceftazidime arginine with correspondingly greater 0-7 h AUC values. The mean AUCs were almost identical after the 2 g injections.
Davies
B I
BI
Maesen
F P
FP
Baur
C
C
Evers
W B
WB
D000368:Aged; D001120:Arginine; D001991:Bronchitis / Q000382:microbiology; D002442:Ceftazidime / Q000627:therapeutic use*; D055598:Chemical Phenomena; D002621:Chemistry; D002908:Chronic Disease; D004339:Drug Compounding; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012141:Respiratory Tract Infections / Q000097:blood / Q000188:drug therapy*
D001120:Arginine; D002442:Ceftazidime