title: [Possible role of protein kinase C in the T-lymphocyte cell cycle].
abstract: Experimental results of induction of T-lymphocyte proliferation by means of tumor promotors-activators of protein kinase C (PKC) are reviewed. A hypothesis has been put forward that the discrepancy of the data so far available can be explained on the account of the difference in membrane-associated PKC activation patterns produced by tumor promotors and by interleukin 2. It is established that the former induce a permanent PKC activation, whereas the latter induces a transient one. Although enhancing DNA synthesis, the permanent (non-physiological) activation must induce an accumulation of cells in the cell cycle phases following the S-phase.
authors.forename: A E
authors.initials: AE
authors.lastname: Vinogradov
authors.forename: S A
authors.initials: SA
authors.lastname: Ezhevskiĭ
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004789:Enzyme Activation / Q000187:drug effects; D007376:Interleukin-2 / Q000494:pharmacology; D011493:Protein Kinase C / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology* / Q000187:drug effects / Q000201:enzymology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D002273:Carcinogens; D007376:Interleukin-2; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate
vernacular_title: Vozmozhnaia rol' proteinkinazy C v kletochnom tsikle T-limfotsitov.