Arterial effects of aldosterone and antimineralocorticoid compounds mechanism of action.
The aim of our work was to study the mechanism of action of aldosterone and antialdosterone compounds on Na+ and K+ fluxes in vascular smooth muscle. In the long term, regulation of salt metabolism depends on aldosterone effects on Na+, K+, H+ and H2O transport by the renal tubules. Furthermore, it has been shown that aldosterone modifies several epithelial transports, inducing a positive sodium balance. The chronic in vivo administration of aldosterone modifies transmembrane ionic fluxes in vascular smooth muscle. Garwitz and Jones suggested that aldosterone may enhance net Na+ transport through the stimulation of the sodium pump. The results obtained in our laboratory indicate that aldosterone has a direct stimulatory action on ouabain-dependent and on ouabain-independent Na efflux. Furthermore, the mineralocorticoid enhances passive K permeability, as well as the Na pump dependent K influx. Both effects are blocked by antimineralocorticoid compounds. Recent experiments have shown that vasopressin potentiates some of the in vivo effects of aldosterone.
Worcel
M
M
Centre de Recherches Roussel Uclaf, Romainville, France.
Moura
A M
AM
D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011910:Rats, Brattleboro; D011919:Rats, Inbred Strains; D012414:Rubidium Radioisotopes / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D014667:Vasopressins / Q000097:blood / Q000494:pharmacology
D000451:Mineralocorticoid Receptor Antagonists; D012414:Rubidium Radioisotopes; D014667:Vasopressins; D000450:Aldosterone; D012964:Sodium; D011188:Potassium