Neutralization of P blood group antibodies by synthetic solid-phase antigens.
P blood group system antibodies are encountered frequently in clinical transfusion practice. The authors describe an improved method for removing P antibodies from patient specimens without dilution. Solid-phase synthetic P antigens were used to neutralize serums containing P blood group system antibodies; 26 alloantibodies with specificity other than P were not inhibited. The synthetic P antigens are also used to characterize the heterogeneous immunochemical fine specificity of antibodies to P1 and P + P1 + Pk.
Cowles
J W
JW
Blumberg
N
N
D000328:Adult; D000906:Antibodies / Q000276:immunology*; D000918:Antibody Specificity; D000941:Antigens; D001789:Blood Group Antigens / Q000276:immunology*; D006801:Humans; D007163:Immunosorbent Techniques; D007518:Isoantibodies / Q000032:analysis / Q000276:immunology; D008297:Male; D009500:Neutralization Tests / Q000379:methods*; D010127:P Blood-Group System / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology
D000906:Antibodies; D000941:Antigens; D001789:Blood Group Antigens; D007518:Isoantibodies; D010127:P Blood-Group System; D014614:Vaccines, Synthetic