Cardioprotection by anti-ischaemic and cytoprotective drugs.
Cardioprotective drugs are agents that prevent or moderate harmful consequences of impaired cardiac energetics, such as sudden coronary death (SCD) due to early post-occlusion ventricular fibrillation (EPVF), development of incapacitating myocardial necrosis. Cardioprotection may be due to anti-ischaemic action, correcting the imbalance between vascular supply and myocardial demand for blood, but also to cytoprotective effect, preserving cellular integrity in the presence of factors damaging structure and function of the cardiac cell membrane such as ischaemia, ionic imbalance and that of pH, etc. Neither anti-ischaemic nor cytoprotective effect alone, or in combination, are sufficient to warrant full cardioprotection, i.e. both prevention of SCD and limitation of infarct size. Thus the beta-blocker pindolol which is anti-ischaemic in its effect reducing myocardial O2 demand and protects from SCD and EVFP, failed to limit infarct size. Even interventions of a mainly cytoprotective type of action protecting from SCD and EPVF, such as the linoleic acid-rich diet, or lidocaine, were unable to limit infarct size, 7-oxoPGI2 (anti-ischaemic and cytoprotective) failed to protect from SCD, VF and did not limit infarct size. On the other hand the nonsteroidal anti-inflammatory drugs which, like salicylates or sulfinpyrazon, reduce myocardial O2 demand and protect from post-occlusion SCD and EPVF, effectively limiting infarct size.
Szekeres
L
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Department of Pharmacology, University Medical School of Szeged, Hungary.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D003327:Coronary Disease / Q000517:prevention & control*; D003645:Death, Sudden; D004041:Dietary Fats; D011464:Epoprostenol / Q000627:therapeutic use* / Q000031:analogs & derivatives; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000503:physiopathology; D010869:Pindolol / Q000627:therapeutic use*
D004041:Dietary Fats; D008041:Linoleic Acids; C033705:7-oxoprostaglandin I2; D008012:Lidocaine; D019787:Linoleic Acid; D010869:Pindolol; D011464:Epoprostenol