The effect of ethanol on serum cyclosporine A levels in renal transplant recipients.
Following an alcohol binge, cyclosporine A (CyA) levels rose by 100% in a 51-year-old transplant recipient treated with CyA. As CyA and ethanol are both metabolized by the cytochrome P-450 enzyme system, ethanol could theoretically interfere with CyA metabolism. Therefore, eight male renal transplant recipients were assessed in a crossover study to determine the effects of acute ethanol ingestion on CyA serum concentrations. CyA serum concentrations did not rise following 50 mL of 100% alcohol. We conclude that heavy alcohol intake may increase CyA levels but that acute moderate intake does not.
Paul
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Parfrey
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Smart
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Gault
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D000328:Adult; D003524:Cyclosporins / Q000097:blood* / Q000627:therapeutic use; D000431:Ethanol / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010919:Placebos; D013997:Time Factors
D003524:Cyclosporins; D010919:Placebos; D000431:Ethanol