Chicken II luteinizing hormone-releasing hormone inhibits the M-current of bullfrog sympathetic neurons.
The M-current of dissociated bullfrog sympathetic neurons, measured by the whole-cell patch clamp technique, is powerfully inhibited by chicken II LH-RH (luteinizing hormone-releasing hormone), with 50% inhibition near 1 nM. Chicken II LH-RH is approximately 100 times more potent than salmon LH-RH, and at least 1000 times more potent than other known naturally occurring LH-RH analogs (chicken I LH-RH, mammalian LH-RH, and lamprey LH-RH). This high potency makes chicken II LH-RH a candidate for the endogenous transmitter mediating the late, slow excitatory postsynaptic potential (EPSP) in bullfrog sympathetic ganglia.
Jones
S W
SW
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106.
D000200:Action Potentials / Q000187:drug effects; D000320:Adrenergic Fibers / Q000187:drug effects / Q000502:physiology*; D000595:Amino Acid Sequence; D000818:Animals; D002469:Cell Separation; D002645:Chickens; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000494:pharmacology*; D066298:In Vitro Techniques; D011892:Rana catesbeiana; D013045:Species Specificity
D007987:Gonadotropin-Releasing Hormone