title: Immunosuppressive therapy in systemic lupus erythematosus.
abstract: The therapeutic efficacy of immunosuppressive therapy in lupus and lupus nephritis in particular, is reviewed. We have tried to resolve the paradox between the observed immunostimulatory effects of cyclophosphamide and cyclosporin A in vivo and our concept of an immunosuppressive agent.
authors.forename: A S
authors.initials: AS
authors.lastname: Russell
authors.forename: P A
authors.initials: PA
authors.lastname: Bretscher
mesh_terms: D001379:Azathioprine / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000627:therapeutic use; D004311:Double-Blind Method; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008213:Lymphocyte Activation / Q000187:drug effects; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D001379:Azathioprine; D011241:Prednisone