title: Role of class I and class II HLA antigens in cadaveric renal transplantation.
abstract: HLA matching at MT and DQ appears to be an important predictor of allograft survival. Allografts with no MM at MT and DQ have a good outcome while a known MM at MT and DQ appears to be associated with poor allograft outcome. Thus, our priority should be to avoid an MM for these broad-reacting specificities and then to minimize incompatibilities at DR and HLA-B. Furthermore, our data indicate that allografts with MM at DQ and two MMs at HLA-B appear to be at a higher risk. Perhaps these latter transplants should not be performed with conventional immunosuppressive therapy.
authors.forename: D P
authors.initials: DP
authors.lastname: Sengar
authors.forename: R A
authors.initials: RA
authors.lastname: Couture
authors.forename: S
authors.initials: S
authors.lastname: Raman
authors.forename: S L
authors.initials: SL
authors.lastname: Jindal
authors.forename: A I
authors.initials: AI
authors.lastname: Lazarovits
mesh_terms: D002102:Cadaver; D006085:Graft Survival; D006681:HLA-D Antigens / Q000276:immunology*; D006683:HLA-DQ Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D013997:Time Factors
chemical_list: D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens