title: Prehospital administration of anisoylated plasminogen streptokinase activator complex in acute myocardial infarction.
abstract: 25 patients have been included in a randomised trial aimed to compare prehospital and hospital administration of anisoylated plasminogen streptokinase activator complex (AP-SAC). Patients were first seen, at home, by a noncardiologist doctor working in a mobile-care unit and were then evaluated for entry into the study. If they had evidence of myocardial infarction lasting for less than 3 hours and if there was no contraindication to thrombolytic therapy they were randomly allocated to APSAC 30U or placebo. They were next referred to an intensive coronary unit (ICU). On arrival in the ICU patients were reevaluated and received APSAC if they had previously received placebo. For 24 patients, diagnosis of myocardial infarction was confirmed. One patient died at home after having received placebo. There was 1 hospital death. At-home injection was made within a median of 124 minutes after the beginning of pain, whereas hospital administration was made after a median of 180 minutes. On a clinical basis reperfusion occurred in 16 out of 21 evaluable patients. Four patients had coronary artery bypass graft surgery and 9 had angioplasty. We conclude that prehospital administration of APSAC is feasible, well-tolerated and is a good way to shorten the delay of thrombolytic treatment in myocardial infarction.
authors.affiliation: Department of Cardiology, Hôspital Henri Mondor, Creteil.
authors.forename: A D
authors.initials: AD
authors.lastname: Castaigne
authors.forename: A M
authors.initials: AM
authors.lastname: Duval
authors.forename: J L
authors.initials: JL
authors.lastname: Dubois-Rande
authors.forename: C
authors.initials: C
authors.lastname: Herve
authors.forename: F
authors.initials: F
authors.lastname: Jan
authors.forename: Y
authors.initials: Y
authors.lastname: Louvard
mesh_terms: D000328:Adult; D000368:Aged; D016255:Anistreplase; D004562:Electrocardiography; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008952:Mobile Health Units; D009203:Myocardial Infarction / Q000188:drug therapy*; D010958:Plasminogen / Q000008:administration & dosage*; D011897:Random Allocation; D013300:Streptokinase / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D005343:Fibrinolytic Agents; D016255:Anistreplase; D010958:Plasminogen; D013300:Streptokinase