title: Effect of various disease states on theophylline plasma levels and on pulmonary function in patients with chronic airway obstruction treated with a sustained release theophylline preparation.
abstract: Theophylline plasma levels and FEV1 were measured in patients affected by chronic obstructive pulmonary disease and a concomitant disease state (congestive heart failure, chronic cor pulmonale, obesity, peptic disease, hepatic cirrhosis, chronic renal failure) and treated with a sustained release theophylline preparation. Our results indicate that, only in patients affected by congestive heart failure and chronic cor pulmonale, is there a decreased plasma clearance of the drug. Low levels of plasma theophylline were measured in obese patients probably because they received an inadequate posology.
authors.forename: R
authors.initials: R
authors.lastname: Dal Negro
authors.forename: P
authors.initials: P
authors.lastname: Turco
authors.forename: C
authors.initials: C
authors.lastname: Pomari
authors.forename: P
authors.initials: P
authors.lastname: Monici-Preti
mesh_terms: D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004066:Digestive System Diseases / Q000097:blood / Q000150:complications; D006331:Heart Diseases / Q000097:blood / Q000150:complications; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications; D007700:Kinetics; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D009765:Obesity / Q000097:blood / Q000150:complications; D013806:Theophylline / Q000097:blood* / Q000627:therapeutic use
chemical_list: D003692:Delayed-Action Preparations; D013806:Theophylline