[Hemolytic graft versus host reaction cause by immune "auto"-anti A1 formation in an A1 recipient following transplantation of an O kidney. With a review of studies up to now from the literature].
The serological data are given of a patient with acquired haemolytic anaemia due to "auto"-antibodies of Anti A1 specificity induced by a group O kidney graft in an A1 recipient as a Graft-versus-Host (GvH) reaction. The gamma-globulin markers Gm (a,x,f) were tested for differentiation between auto- or alloantibody character of the patients "Auto"-Anti A1. The possibility of in vivo neutralization of the Immune-Anti A1 by blood group substance A in the plasma of the patient could not be proven, though initially presumed. The disadvantages of using ABO compatible, but not identical organ donors is pointed out, firstly the possibility of giving rise to ABO induced GvH reactions and, secondly, the reduced chance of group O recipients on the waiting list getting group O graft. A search of the literature revealed 46 similar cases, which are reviewed and their characteristics are discussed.
Pausch
V
V
Institut für Blutgruppenserologie, Universität Wien.
Speiser
P
P
D000017:ABO Blood-Group System / Q000276:immunology*; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D006084:Graft Rejection; D006087:Graft vs Host Reaction; D006801:Humans; D016030:Kidney Transplantation; D014181:Transplantation Immunology
D000017:ABO Blood-Group System; D001323:Autoantibodies
Uber eine hämolytische Graft-versus-Host-Reaktion durch Immun-"Auto"-Anti A1-Bildung im A1-Empfänger nach Transplantation einer O-Niere. Mit einer Ubersicht bisheriger Beobachtungen aus dem Schrifttum.