title: Demonstration of pepsinogen C in human pancreatic islets.
abstract: Pancreatic tissue from 16 post mortem kidney donors have been examined for the content of pepsinogens. A zymogen with electrophoretic mobility, isoelectric point and molecular weight equal to that of pepsinogen C of gastric origin was found in all specimens. A comparison between pepsinogen C extracted from pancreatic tissue and gastric mucosa demonstrated immunological identity. Quantitative measurements with a radioimmunoassay showed pepsinogen C concentrations in pancreatic tissue three to 80 times higher than those of blood serum. Immunohistochemical staining gave positive reaction for pepsinogen C only in the alpha cells of the pancreatic islets.
authors.affiliation: Department of Clinical Chemistry, Hvidovre Hospital, Denmark.
authors.forename: P B
authors.initials: PB
authors.lastname: Szecsi
authors.forename: H
authors.initials: H
authors.lastname: Halgreen
authors.forename: S S
authors.initials: SS
authors.lastname: Poulsen
authors.forename: C K
authors.initials: CK
authors.lastname: Axelsson
authors.forename: M
authors.initials: M
authors.lastname: Damkjaer-Nielsen
authors.forename: T
authors.initials: T
authors.lastname: Kjaer
authors.forename: B
authors.initials: B
authors.lastname: Foltmann
mesh_terms: D004587:Electrophoresis, Agar Gel; D004591:Electrophoresis, Polyacrylamide Gel; D005753:Gastric Mucosa / Q000201:enzymology; D006801:Humans; D007124:Immunoenzyme Techniques; D007515:Islets of Langerhans / Q000032:analysis / Q000201:enzymology*; D007525:Isoelectric Focusing; D010435:Pepsinogens / Q000032:analysis / Q000378:metabolism*
chemical_list: D010435:Pepsinogens