title: Effects of low molecular weight fibrin degradation products 6A and 6D on rabbit aorta strips.
abstract: Two small molecular weight fibrin degradation product, the pentapeptide 6A and the undecapeptide 6D, produced relaxations of norepinephrine-contracted rabbit aorta strips. The relaxations were slow-developing and were elicited by both peptides at supramicromolar concentrations; the amplitude of relaxations were small for 6D. The relaxations induced by 6A were not dependent on the presence of endothelium and were not modified by a mixture of indomethacin, pyrilamine, and cimetidine. The amplitude of the relaxations produced by 6A and 6D increased as a function of incubation time in vitro. In another experimental system, peptides 6A and 6D failed to increase 6-keto-PGF1 alpha release from cultured human umbilical endothelial cells. Histamine and bradykinin were both active in this system.
authors.affiliation: Unité de Recherche sur l'Inflammation, C.H.U.L., Québec, Canada.
authors.forename: F
authors.initials: F
authors.lastname: Marceau
authors.forename: J
authors.initials: J
authors.lastname: Bouthillier
authors.forename: B
authors.initials: B
authors.lastname: Tremblay
authors.forename: S
authors.initials: S
authors.lastname: St-Pierre
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D004730:Endothelium, Vascular / Q000502:physiology*; D011464:Epoprostenol / Q000378:metabolism; D005338:Fibrin Fibrinogen Degradation Products / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D009126:Muscle Relaxation / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D010455:Peptides; D015121:6-Ketoprostaglandin F1 alpha; D006632:Histamine; D011464:Epoprostenol