title: Failure of noncaloric sweet drinking to prevent the fasting-induced inhibition of insulin release.
abstract: Rats were fasted for 24 or 48 h, but given free access to either water or a sweet-tasting solution of saccharin. Fasting caused a time-related decrease in body weight, plasma glucose and insulin concentrations, and insulin output from isolated pancreatic islets incubated at increasing concentrations of D-glucose. The concentration of the hexose causing half-maximal stimulation of insulin release was increased, in a time-related manner, in islets removed from fasted rats. Except for a somewhat lesser decrease in plasma glucose concentration, ingestion of the sweet drinking water failed to affect the fasting-induced changes in body weight, plasma insulin concentration and insulin output.
authors.affiliation: Laboratory of Experimental Medicine, Brussels Free University, Belgium.
authors.forename: M C
authors.initials: MC
authors.lastname: Segura
authors.forename: W J
authors.initials: WJ
authors.lastname: Malaisse
mesh_terms: D000818:Animals; D005215:Fasting; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012439:Saccharin / Q000494:pharmacology*
chemical_list: D007328:Insulin; D012439:Saccharin; D005947:Glucose