Long-term monitoring of renal transplant patients by a CUSUM test on serum creatinine.
A retrospective clinical assessment of kidney function change was performed on 38 kidney transplant patients over a median follow-up period of 128 weeks. Full records of the patients' course were available to the clinician, while only the serum creatinine series of each patient was supplied to the computer on which a bilateral CUSUM test was implemented. The frequency of change assessed by the clinician was 146 out of 2,688 patient-weeks. The computer identified the function changes with 84.9% sensitivity and 94.3% specificity and the function deteriorations attributed to rejection with 88.9% sensitivity and 97.2% specificity. Thus we suggest an efficient long-term monitoring of the graft function with this simple and reliable statistical technique.
Piccoli
A
A
Institute of Internal Medicine, University of Padova, Italy.
Rizzoni
G
G
Tessarin
C
C
Calconi
G
G
Filippini
M
M
Dugo
M
M
Borsatti
A
A
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood*; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013997:Time Factors
D003404:Creatinine