Recognition of a polymorphic monocyte antigen.
138 sera from renal transplant recipients were screened for the presence of monocyte-specific antibodies. Most of the sera contained antibodies against monocytes, T- and/or B-lymphocytes. One serum was identified which defined a monocyte-specific antigen, MOLI. This serum was investigated in intensive population and family studies for the estimation of the formal genetic criteria of this 'new' monocyte antigen. A gene frequency of 0.0614 was obtained by population analysis. Family investigations conveyed the information that the gene coding for MOLI was transmitted in linkage with HLA genes. A positive linkage disequilibrium of MOLI and HLA-B17 was found.
Menzel
G R
GR
Blood Transfusion Centre Berlin, GDR.
Rose
M
M
D000906:Antibodies / Q000276:immunology; D000941:Antigens / Q000235:genetics / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D005787:Gene Frequency; D008040:Genetic Linkage; D006801:Humans; D016030:Kidney Transplantation; D009000:Monocytes / Q000276:immunology*; D010375:Pedigree; D013601:T-Lymphocytes / Q000276:immunology
D000906:Antibodies; D000941:Antigens