title: Female sexual behavior in hypogonadal mice with GnRH-containing brain grafts.
abstract: Hypogonadal female mice respond to GnRH-containing fetal preoptic area (POA) implants in the third ventricle with vaginal opening and persistent vaginal estrus, ovarian, and uterine development and increased gonadotropin secretion. When these females are mated with normal males, reflex ovulation results in pregnancy. In the present study, POA implants derived from neonatal pups, whether male or female, were also capable of supporting reproductive development in the hypogonadal female mice. Evaluation of female sexual behavior in the mice with grafts showed that these mice responded to normal males with comparable levels of lordosis as are seen in normal female mice on the proestrous days of their cycles.
authors.forename: M J
authors.initials: MJ
authors.lastname: Gibson
authors.forename: H C
authors.initials: HC
authors.lastname: Moscovitz
authors.forename: G J
authors.initials: GJ
authors.lastname: Kokoris
authors.forename: A J
authors.initials: AJ
authors.lastname: Silverman
mesh_terms: D000818:Animals; D005260:Female; D008141:Lordosis; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology*; D011301:Preoptic Area / Q000637:transplantation; D011930:Reaction Time; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects
chemical_list: D010906:Pituitary Hormone-Releasing Hormones