[Benign and malignant granular cell tumors. An immunohistochemical classification of tumor cells].
Eight benign and three malignant granular cell tumors were characterized by means of antibodies and antisera against keratin, desmin, epithelial membrane antigen, factor VIII-related protein, lysozyme, myelin basic protein, myoglobin, neurone-specific enolase, S 100 protein, myelin-associated protein (Leu 7), glial fibrillary acidic protein, vimentin, and neurofilament. All benign granular cell tumours showed positive staining of the tumor cells to antibodies against vimentin, S 100 protein, and neurone-specific enolase; myelin-associated protein (Leu 7), in contrast, was only detectable in a few tumor sections. Histogenetically the granular cells may be classified as Schwann's cells which lost their expression of laminin. The three malignant granular cell tumors showed a staining pattern significantly different from that of the benign tumours. Thus, only neurone-specific enolase was detectable in all the tumors, whereas S 100 protein and vimentin could not be demonstrated but in one and two, resp., out of three tumors.
Kuhn
A
A
Mahrle
G
G
Steigleder
G K
GK
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D006801:Humans; D007124:Immunoenzyme Techniques; D008938:Mitosis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm
Benigne und maligne Granularzelltumoren. Eine immunhistochemische Klassifizierung der Tumorzellen.