The islets of Langerhans in uremic patients receiving chronic hemodialysis.
Ten autopsied cases of uremia (none with diabetes mellitus) who had been treated with hemodialysis were studied histopathologically. Hyaline replacement of islets of Langerhans was found in 6 out of 10 cases, while such a change was observed in only 1 of 15 control non hemodialzyed controls. These 6 cases had received hemodialysis therapy for a duration of more than 2 years and 10 months. The hyaline material in the islets of Langerhans was confirmed as the presence of amyloid by electron microscopy. Clinically, urinary glucose was present in 1 out of 3 patients and the blood glucose level was moderately elevated in 2 other cases. Therefore, it should be emphasized that care should be taken about glucose tolerance in uremic patients receiving chronic hemodialysis.
Suda
K
K
Ariwa
R
R
D000328:Adult; D000368:Aged; D000682:Amyloid / Q000032:analysis; D005260:Female; D005947:Glucose / Q000032:analysis; D006801:Humans; D007515:Islets of Langerhans / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014511:Uremia / Q000378:metabolism / Q000473:pathology* / Q000628:therapy
D000682:Amyloid; D005947:Glucose