Induction of the SOS response by new 4-quinolones.
The 4-quinolones ciprofloxacin, difloxacin, enoxacin, norfloxacin, ofloxacin, and nalidixic acid were found to induce the SOS response in qualitative and quantitative tests on Escherichia coli K12 containing the sfiA::lacZ gene fusion. Maximum induction of the SOS-response was observed with the quinolone concentrations that produced the most killing. There was also a modest increase in the rate of mutation in the lactose and galactose operons in a GalE- background, provided there was a functioning SOS system.
Phillips
I
I
Department of Microbiology, Hospital Ramon y Cajal, Madrid, Spain.
Culebras
E
E
Moreno
F
F
Baquero
F
F
D004260:DNA Repair / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D008826:Microbial Sensitivity Tests; D009153:Mutagens; D011804:Quinolines / Q000494:pharmacology*; D013014:SOS Response, Genetics / Q000187:drug effects*
D009153:Mutagens; D011804:Quinolines