Leucocyte migration inhibition in diphtheria toxoid hypersensitivity.
A donor who was highly reactive to diphtheria toxoid (DT) in delayed hypersensitivity and in lymphocyte transformation showed scant evidence of antigen-induced inhibition in the direct leucocyte migration agarose test. Other donors, weak or negative to DT in skin test and transformation, did show evidence of inhibition. Although the migration test is useful in assessing cellular reactivity to tubercular antigen, these results question its suitability for DT.
Saxby
M F
MF
Department of Immunology, St. Mary's Hospital Medical School, London, U.K.
Salaman
M R
MR
Sargent
I L
IL
D000328:Adult; D002464:Cell Migration Inhibition; D004168:Diphtheria Toxoid / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology* / Q000276:immunology; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis; D007962:Leukocytes / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D014374:Tuberculin Test
D004168:Diphtheria Toxoid; D007961:Leukocyte Migration-Inhibitory Factors