title: Bypass disease.
abstract: Intestinal bypass surgery as a treatment for morbid obesity was quite popular from 1965 to 1975 in the United States. The procedure was successful in reducing body weight but was controversial because of a high rate of complications which included an arthritis-dermatitis syndrome. Herein we review the knowledge garnered from a study of the complications from intestinal bypass surgery. Emphasis is placed on an analysis of the clinical manifestations, and the pathogenesis of the arthritis-dermatitis bypass syndrome, and how bypass disease may serve as a model for immune complex-mediated disease and for extra-intestinal complications in other enteropathies.
authors.affiliation: Department of Rheumatology, Mount Sinai Hospital, Medical Center, Chicago, Illinois.
authors.forename: J
authors.initials: J
authors.lastname: Clarke
authors.forename: S R
authors.initials: SR
authors.lastname: Weiner
authors.forename: L W
authors.initials: LW
authors.lastname: Bassett
authors.forename: P D
authors.initials: PD
authors.lastname: Utsinger
mesh_terms: D001168:Arthritis / Q000209:etiology*; D003872:Dermatitis / Q000209:etiology*; D006801:Humans; D007410:Intestinal Diseases / Q000209:etiology; D007581:Jejunoileal Bypass / Q000009:adverse effects*; D008107:Liver Diseases / Q000209:etiology