title: Plasmodium falciparum in Kinshasa, Zaire: in vitro drug susceptibility studies.
abstract: In June 1986, Plasmodium falciparum parasites were collected from 33 children presenting at the Mama Yemo Hospital in Kinshasa (Zaire) and were successfully tested in vitro by a 48-hr reinvasion test for their susceptibility to various antimalarial drugs. In vitro resistance to chloroquine was found in 82% of the isolates, a marked increase over findings obtained by the same technique 3 years ago in Kinshasa. In vitro chloroquine resistance was not associated with a history of previous drug intake. The inhibitory endpoints for quinine varied from 0.03 to 1 microM, and correlated with the chloroquine endpoints in the corresponding isolates (r = 0.64). Pyrimethamine resistance in vitro was demonstrated in 52% of the isolates tested.
authors.affiliation: Division of Parasitic Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
authors.forename: P
authors.initials: P
authors.lastname: Nguyen-Dinh
authors.forename: A E
authors.initials: AE
authors.lastname: Greenberg
authors.forename: N
authors.initials: N
authors.lastname: Kabote
authors.forename: F
authors.initials: F
authors.lastname: Davachi
authors.forename: B
authors.initials: B
authors.lastname: Goussard
authors.forename: B
authors.initials: B
authors.lastname: Embonga
mesh_terms: D000818:Animals; D002648:Child; D002738:Chloroquine / Q000627:therapeutic use; D015023:Democratic Republic of the Congo; D004351:Drug Resistance; D006801:Humans; D008288:Malaria / Q000188:drug therapy; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000627:therapeutic use; D011803:Quinine / Q000627:therapeutic use
chemical_list: D002738:Chloroquine; D011803:Quinine; D011739:Pyrimethamine