Unexpected normal serum beta-microglobulin (B2M) levels in multiple myeloma.
Measuring serum beta-2-microglobulin (B2M) in 90 patients with multiple myeloma (MM) from diagnosis to death (83 cases), or to the terminal phase of their disease (7 cases), we have obtained evidence that 9% of them retained normal serum B2M levels during the whole of their follow-up. This was observed in 6 IgA MM, in one light chain MM only and in one non-secretory MM. These data suggest a lack of B2M production and/or secretion by some myeloma tumors. This could limit the use of B2M as clinical marker in MM.
Bataille
R
R
Grenier
J
J
Sany
J
J
D006801:Humans; D009101:Multiple Myeloma / Q000097:blood* / Q000401:mortality; D001613:beta 2-Microglobulin / Q000032:analysis*
D001613:beta 2-Microglobulin