title: [Malaria and pregnancy. Comparative study of Central Africa and Western Africa].
abstract: The transmission of malaria occurs mainly in and following the rainy season (intermittent transmission) in the Sahelian zone of Africa. On the other hand in rainy Equatorial Africa the transmission of malaria is continuous so that it is stable and can give rise to continuous antigenic stimulation in pregnant women which in turn gives rise to passive early high level immunity in the infant. 150 couples of mother and cord blood and 206 placentae were studied. We found 12.1% of carriers of blood parasites in the blood as compared with 1.6% in the cord bloods (exclusively P. falciparum). Where there were medium quantities of fluorescent antibodies in the mothers 74% could be found in the cord serum. Two methods were used to measure antimalarial antibodies as evidence of infection and also partly protective: the first method was indirect immunofluorescence, and the second was co-electrosyneresis. There was a narrow correlation between the level of precipitant antibodies in the mothers who were infected and in the fetal cord bloods. Anatomo-pathological examination of the placenta showed that 2 out of the 206 had parasites in them, 9 out of the 206 had fibrin deposits around the villi and 6.8% of the placentae showed lesions of malaria. On the other hand, in West Africa there was very little maternal morbidity as evidence by fever and anaemia, or of fetal morbidity. There was no single case of congenital malaria. The levels of the plasma indices in the towns could be explained because of prophylaxis which was both controlled and uncontrolled.
authors.forename: R D
authors.initials: RD
authors.lastname: Zinsou
authors.forename: T
authors.initials: T
authors.lastname: Engongah-Beka
authors.forename: D
authors.initials: D
authors.lastname: Richard-Lenoble
authors.forename: E
authors.initials: E
authors.lastname: Philippe
authors.forename: A
authors.initials: A
authors.lastname: Awassi
authors.forename: M
authors.initials: M
authors.lastname: Kombila
mesh_terms: D000350:Africa, Central; D000354:Africa, Western; D000906:Antibodies / Q000032:analysis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008288:Malaria / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D010963:Plasmodium falciparum / Q000276:immunology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D012621:Seasons
chemical_list: D000906:Antibodies
vernacular_title: Paludisme et grossesse. Etude comparative entre l'Afrique Centrale et l'Afrique de l'Ouest.