title: [From clinical action to the elucidation of mechanism of action: 20 years of research on Primperan].
abstract: For twenty years, metoclopramide has been widely used as an antiemetic and digestive motility modifier. The mechanism of metoclopramide's antiemetic effect has been elucidated : it involves a block of the dopaminergic receptors located in the trigger zone of the floor of the fourth ventricle. Metoclopramide's effect on motricity is due to an indirect cholinergic action : metoclopramide enhances cholinergic transmission by blocking serotoninergic receptors. Through its central action, metoclopramide neutralizes the effect of stress on digestive motricity, whereas domperidone, a drug with a strictly peripheral action, is ineffective in this form of digestive pathogenesis.
authors.affiliation: Centre Médical, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Quivy
mesh_terms: D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D008787:Metoclopramide / Q000494:pharmacology* / Q000627:therapeutic use; D011954:Receptors, Dopamine / Q000187:drug effects
chemical_list: D011954:Receptors, Dopamine; D008787:Metoclopramide
vernacular_title: De l'activité clinique à la compréhension de son mécanisme d'action: vingt ans de recherche sur le primpéran.