[Approaches to the creation of a model of cerebral thrombocytic microembolism and to research on the effects of drugs].
It is shown that the introduction of collagen into the carotid artery brings forth an increase in perfusion pressure during cat cerebral autoperfusion due to blockade of micro-vessels by platelet aggregates. This increase is of a transitory character and is accompanied by changes in the acid-base balance of the arterial blood towards acidosis. It has been established that papaverine and cavinton (vinpocetine) do not cause recanalization of the blocked microvessels, and in case of verapamil it is of a partial character. The infusion of prostacyclin brings about an almost total recanalization of microvessels and prevents intravascular aggregation upon collagen application. It is concluded that this model may prove useful in the selection of drugs for the pathological therapy of cerebral dysfunctions.
Akopov
S E
SE
Sarkisian
S B
SB
Gabrielian
E S
ES
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003094:Collagen / Q000008:administration & dosage; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D011464:Epoprostenol / Q000627:therapeutic use; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D002542:Intracranial Embolism and Thrombosis / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D008722:Methods; D010208:Papaverine / Q000627:therapeutic use; D010974:Platelet Aggregation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000627:therapeutic use; D014700:Verapamil / Q000627:therapeutic use; D014748:Vinca Alkaloids / Q000627:therapeutic use
D005343:Fibrinolytic Agents; D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C013983:vinpocetine; D003094:Collagen; D014700:Verapamil; D010208:Papaverine; D011464:Epoprostenol
Podkhody k sozdaniiu modeli trombotsitarnoĭ mikroémbolii mozga i issledovaniiu vliianiia na nee lekarstvennykh sredstv.