[Hereditary angioedema: changes in serum levels of C4 in response to danazol].
12 patients (7 males and 5 females) suffering from the common form of HAE were included in the study protocol. All patients were older than 18 years. They were evaluated Cl INH, C4, Clq, Cls, C3, C5, C8, Bf, CH 50% and CIC. For the purpose of the study they were only considered Cl INH, C4, CH 50%, CIs and CIC levels. The rest of the complement components were among normal values. Data were recorded at day 0 and after 10 days on treatment with 400 mg/day of Danazol. Results were as follows: 50% of the patients had CIC when CH 50% values were below 120 U/ml., after treatment CIC disappeared and CH 50, Cls, C4 and Cl INH increased significatively. C4 seemed to increase more and quicker than Cl INH in terms of absolute values. We postulate that in the group of patients with CIC, the primary cause of the disease may be an alteration in C4 synthesis and that Cl INH may be lowered because of its consumption. We postulate that Danazol could act in these cases stimulating C4 synthesis independently or in accordance with Cl INH.
Egidio Fabiani
J
J
Instituto Argentino de Alergia e Inmunología.
Squiquera
L
L
Leoni
J
J
Simkin
G
G
Casala
A
A
D000328:Adult; D000799:Angioedema / Q000097:blood* / Q000188:drug therapy / Q000235:genetics; D000936:Antigen-Antibody Complex / Q000378:metabolism; D003174:Complement C1 Inactivator Proteins / Q000097:blood; D003181:Complement C4 / Q000378:metabolism*; D003613:Danazol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011245:Pregnadienes / Q000627:therapeutic use*; D013997:Time Factors
D000936:Antigen-Antibody Complex; D003174:Complement C1 Inactivator Proteins; D003181:Complement C4; D011245:Pregnadienes; D003613:Danazol
Angioedema hereditario: variaciones de los niveles séricos de C4 en respuesta a danazol.