Effect of various disease states on theophylline plasma levels and on pulmonary function in patients with chronic airway obstruction treated with a sustained release theophylline preparation.
Theophylline plasma levels and FEV1 were measured in patients affected by chronic obstructive pulmonary disease and a concomitant disease state (congestive heart failure, chronic cor pulmonale, obesity, peptic disease, hepatic cirrhosis, chronic renal failure) and treated with a sustained release theophylline preparation. Our results indicate that, only in patients affected by congestive heart failure and chronic cor pulmonale, is there a decreased plasma clearance of the drug. Low levels of plasma theophylline were measured in obese patients probably because they received an inadequate posology.
Dal Negro
R
R
Turco
P
P
Pomari
C
C
Monici-Preti
P
P
D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004066:Digestive System Diseases / Q000097:blood / Q000150:complications; D006331:Heart Diseases / Q000097:blood / Q000150:complications; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications; D007700:Kinetics; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D009765:Obesity / Q000097:blood / Q000150:complications; D013806:Theophylline / Q000097:blood* / Q000627:therapeutic use
D003692:Delayed-Action Preparations; D013806:Theophylline