title: A double blind study of 2 mg versus 4 mg nicotine-gum in an industrial setting.
abstract: In a double blind randomised trial to aid smoking cessation a 2 mg nicotine gum (n = 101) was compared with a 4 mg gum (n = 98), in smokers of at least 15 cigarettes/day. The trial involved blue and white collar workers and took place at their working place (industrial setting). Intervention during the one year follow-up period was minimal. At 3 months 36.2% of the 2 mg nicotine gum group reported to have stopped smoking, against 44.8% in the 4 mg group (non-significant difference). At one year in the 2 and 4 mg groups respectively 22.3 and 32.2% reported smoking abstinence (non significant difference). However in a sub-group with a higher nicotine-dependence score, only 18.5% were abstainers at one year in the 2 mg nicotine gum group against 32.9% in the 4 mg nicotine gum, which is a significant difference at the p = 0.05 level. This is however a post-hoc finding and should be taken with caution.
authors.forename: M
authors.initials: M
authors.lastname: Kornitzer
authors.forename: F
authors.initials: F
authors.lastname: Kittel
authors.forename: M
authors.initials: M
authors.lastname: Dramaix
authors.forename: P
authors.initials: P
authors.lastname: Bourdoux
mesh_terms: D001835:Body Weight; D002638:Chewing Gum; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005500:Follow-Up Studies; D006801:Humans; D007221:Industry; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000627:therapeutic use*; D000074606:Smoking Prevention; D013861:Thiocyanates / Q000097:blood
chemical_list: D002638:Chewing Gum; D013861:Thiocyanates; D009538:Nicotine; C031760:thiocyanate