title: Distribution of vitamin B12 R binder in normal human tissues: an immunohistochemical study.
abstract: We studied the distribution of vitamin B12 R binder in various normal human tissues by use of an immunoperoxidase technique. Positive staining for R binder was observed in almost all glandular epithelia of digestive system, bronchial glands, renal proximal tubules, prostate, uterus, Fallopian tube, mammary gland, and sweat glands. The distribution of R binder was similar to that of lactoferrin and secretory component. These findings support the hypothesis that R binder plays a role in the local defense mechanism.
authors.forename: H
authors.initials: H
authors.lastname: Kudo
authors.forename: G
authors.initials: G
authors.lastname: Ohshio
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
authors.forename: Y
authors.initials: Y
authors.lastname: Wakatsuki
authors.forename: M
authors.initials: M
authors.lastname: Inada
authors.forename: Y
authors.initials: Y
authors.lastname: Hamashima
authors.forename: T
authors.initials: T
authors.lastname: Miyake
mesh_terms: D004064:Digestive System / Q000378:metabolism; D004702:Endocrine Glands / Q000378:metabolism; D006413:Hematopoietic System / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D009132:Muscles / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D012137:Respiratory System / Q000378:metabolism; D014018:Tissue Distribution; D014155:Transcobalamins / Q000378:metabolism*; D014566:Urogenital System / Q000378:metabolism; D014805:Vitamin B 12 / Q000378:metabolism*
chemical_list: D014155:Transcobalamins; D014805:Vitamin B 12