Verotoxin production among porcine strains of Escherichia coli and its association with oedema disease.
Strains of Escherichia coli isolated from documented cases of disease in pigs and belonging to a wide range of pathogenic serotypes were tested for their ability to produce a heat labile verotoxin (VT). The strains isolated from oedema disease all produced VT, indicating that the cytotoxin detected by the vero-cell assay was identical to "oedema disease principle". Strains belonging to the serotypes associated with enterotoxic diarrhoea were VT-. Not all the strains belonging to the recognised oedema disease serotypes (O141:K85, O139:K82 and O138:K81) produced VT, but the VT- strains were not associated with outbreaks of clinical disease.
Linggood
M A
MA
Unilever Research, Colworth Laboratory, Sharnbrook, Bedford.
Thompson
J M
JM
D000818:Animals; D001427:Bacterial Toxins / Q000096:biosynthesis*; D003603:Cytotoxins / Q000096:biosynthesis*; D003967:Diarrhea / Q000382:microbiology / Q000662:veterinary; D004488:Edema Disease of Swine / Q000382:microbiology*; D004926:Escherichia coli / Q000145:classification / Q000378:metabolism* / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000382:microbiology / Q000662:veterinary*; D006801:Humans; D009500:Neutralization Tests; D022622:Shiga Toxin 1; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology; D014709:Vero Cells; D014774:Virulence
D001427:Bacterial Toxins; D003603:Cytotoxins; D022622:Shiga Toxin 1