title: Nifedipine in the treatment of Raynaud's phenomenon in patients with systemic sclerosis.
abstract: A double-blind, placebo-controlled, cross-over trial of nifedipine 10 mg three times daily for 6 weeks, in 10 patients with Raynaud's phenomenon secondary to systemic sclerosis, is reported. A significant reduction in the duration of attacks of Raynaud's phenomenon was observed. Nifedipine therapy also reduced the number and severity of attacks of Raynaud's phenomenon and the development of new digital ulcers, and increased the digital blood flow, but none of these changes was statistically significant. No alteration in red blood cell deformability or leukocyte chemiluminescence was observed during nifedipine treatment.
authors.affiliation: Department of Dermatology, St Bartholomew's Hospital, London, U.K.
authors.forename: R H
authors.initials: RH
authors.lastname: Meyrick Thomas
authors.forename: M
authors.initials: M
authors.lastname: Rademaker
authors.forename: S M
authors.initials: SM
authors.lastname: Grimes
authors.forename: A
authors.initials: A
authors.lastname: MacKay
authors.forename: I B
authors.initials: IB
authors.lastname: Kovacs
authors.forename: E D
authors.initials: ED
authors.lastname: Cook
authors.forename: S M
authors.initials: SM
authors.lastname: Bowcock
authors.forename: J D
authors.initials: JD
authors.lastname: Kirby
mesh_terms: D001783:Blood Flow Velocity / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D009543:Nifedipine / Q000627:therapeutic use*; D011928:Raynaud Disease / Q000188:drug therapy* / Q000209:etiology; D012595:Scleroderma, Systemic / Q000150:complications*; D012883:Skin Ulcer / Q000188:drug therapy / Q000209:etiology
chemical_list: D009543:Nifedipine