Vasoactive intestinal polypeptide levels and distribution in the penis of old rats.
Vasoactive intestinal polypeptide (VIP) levels and distribution were studied in the penis of young-adult (3-month-old) and old (30-month-old) Wistar rats by radioimmunoassay and immunofluorescence. No significant changes in tissue VIP concentrations or distribution occurred in the penis of old rats compared to young-adult rats. The present data indicate that the age-related impairment of male sexual function is not dependent on modifications of the VIP-ergic innervation of penile tissue.
Amenta
F
F
Dipartimento di Scienze Neurologiche, Università La Sapienza, Roma, Italy.
Cavallotti
C
C
De Rossi
M
M
Ferrante
F
F
Geppetti
P
P
D000375:Aging / Q000378:metabolism*; D000818:Animals; D005455:Fluorescent Antibody Technique; D008297:Male; D009994:Osmolar Concentration; D010413:Penis / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D014660:Vasoactive Intestinal Peptide