title: Effect of insulin on motilin release in man.
abstract: The effect of insulin on motilin release was investigated by use of the euglycemic glucose clamp technique. By use of this technique plasma glucose concentration was maintained constant at 80-90 mg/100 ml, and plasma insulin immunoreactivity (IRI) was increased from 15 +/- 6 microU/ml to 171 +/- 22 microU/ml in 10 min, and remained at this level for 2 hr. Plasma motilin like immunoreactivity (MLI) concentration decreased within 10 min from 199 +/- 36 pg/ml to 120 +/- 28 pg/ml and remained low during the course of study. A significant negative correlation between MLI and IRI concentrations (r = -0.72, p less than 0.01) was observed. The present results indicate that the suppressive effect of insulin on motilin release is a direct action of insulin and is not mediated by glucose.
authors.affiliation: Department of Internal Medicine (Division of Endocrinology and Metabolism), University of Michigan, Ann Arbor 48109.
authors.forename: A
authors.initials: A
authors.lastname: Funakoshi
authors.forename: D E
authors.initials: DE
authors.lastname: Schteingart
authors.forename: A I
authors.initials: AI
authors.lastname: Vinik
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009037:Motilin / Q000097:blood*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D009037:Motilin