title: Renal amyloidosis in children: an ultrastructural study.
abstract: Eleven renal biopsy specimens from 10 children affected with systemic amyloidosis were studied by electron microscopy. Focal parietal deposits of amyloid fibrils and detachment of podocytes were observed in the 9 patients having marked proteinuria. Adjacent capillary loops were normal with intact podocyte foot processes. In the 2 renal biopsies obtained after treatment of the underlying disease a double layer of subendothelial and subepithelial basement membrane material enclosed the parietal amyloid deposits and separated them from adjacent cells.
authors.affiliation: INSERM U.192, Hôpital Necker Enfants-Malades, Paris, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Gubler
authors.forename: C
authors.initials: C
authors.lastname: Naizot
mesh_terms: D000293:Adolescent; D000686:Amyloidosis / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007668:Kidney / Q000648:ultrastructure*; D007674:Kidney Diseases / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron