Non-pharmacological effects of the use of microelectrophoresis and pressure ejection of drugs in combination.
Pressure ejection of physiological saline from multibarrel micropipette assemblies has been shown to selectively reduce responses of rat spinal cord neurones to electrophoretic ejection of kainate, N-methyl-aspartate and 4-methyl-homoibotenate, but not of quisqualate or L-glutamate. Reduction of response to an excitatory amino acid therefore appears to be correlated with the absence of an active transport system for that amino acid.
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D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D004586:Electrophoresis / Q000379:methods*; D007051:Ibotenic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology; D008839:Microelectrodes; D016202:N-Methylaspartate; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009543:Nifedipine / Q000494:pharmacology; D010069:Oxadiazoles / Q000494:pharmacology; D016318:Quisqualic Acid; D051381:Rats; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*
D000596:Amino Acids; D010069:Oxadiazoles; D007051:Ibotenic Acid; D001224:Aspartic Acid; D016202:N-Methylaspartate; C023364:homoibotenic acid; D016318:Quisqualic Acid; D009543:Nifedipine; D007608:Kainic Acid