title: Pyrimethamine-sulfadoxine still effective against Plasmodium falciparum in Jayapura, Irian Jaya: RI-type resistance in 2 of 18 patients.
abstract: The sensitivity of Plasmodium falciparum infections to pyrimethamine-sulfadoxine was studied in 18 Indonesian patients in Jayapura, Irian Jaya. In 16 of the 18 patients parasitaemia was cleared by day 6 and the patients remained without parasitaemia through day 28. Two of the 18 patients had late recrudescences consistent with RI-type resistance; one each on days 14 and 21. Pyrimethamine-sulfadoxine is still an effective antimalarial for most patients with falciparum malaria in Jayapura.
authors.forename: S L
authors.initials: SL
authors.lastname: Hoffman
authors.forename: J
authors.initials: J
authors.lastname: Campbell
authors.forename: D
authors.initials: D
authors.lastname: Rustama
authors.forename: A J
authors.initials: AJ
authors.lastname: Dimpudus
authors.forename: B
authors.initials: B
authors.lastname: Surumpaet
authors.forename: J
authors.initials: J
authors.lastname: Rusch
authors.forename: H
authors.initials: H
authors.lastname: Marwoto
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations / Q000627:therapeutic use; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007214:Indonesia; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D010963:Plasmodium falciparum / Q000235:genetics; D011739:Pyrimethamine / Q000627:therapeutic use*; D011815:R Factors / Q000187:drug effects; D013413:Sulfadoxine / Q000627:therapeutic use*; D013424:Sulfanilamides / Q000627:therapeutic use*
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; D013424:Sulfanilamides; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011739:Pyrimethamine