Penetration of ceftazidime into heart valves and subcutaneous and muscle tissue of patients undergoing open-heart surgery.
Patients undergoing open-heart surgery were given an intravenous bolus injection of 2 g of ceftazidime as a single dose over a period of 5 min. Within 12 h, ceftazidime concentrations in serum declined from 55.8 to 3.9 mg/liter. Subcutaneous tissue concentrations of the drug decreased from 21.0 to 2.7 micrograms/g, and muscle concentrations decreased from 34.5 to 2.5 micrograms/g. Ceftazidime concentrations in cardiac valvular tissue were even higher than those in muscle or fat, declining from 37.4 to 6.3 micrograms/g within 10 h.
Frank
U
U
Kappstein
I
I
Schmidt-Eisenlohr
E
E
Schlosser
V
V
Spillner
G
G
Schindler
M
M
Daschner
F D
FD
D000273:Adipose Tissue / Q000378:metabolism*; D006348:Cardiac Surgical Procedures; D002442:Ceftazidime / Q000378:metabolism*; D005260:Female; D006351:Heart Valves / Q000378:metabolism*; D006801:Humans; D008297:Male; D009132:Muscles / Q000378:metabolism*; D011292:Premedication; D014018:Tissue Distribution
D002442:Ceftazidime