Opsonizing and agglutinating antibodies against Plasmodium falciparum schizont-infected erythrocytes in Gambian sera.
The presence of an IgG antibody to autologous schizont-infected red blood cells (SIRBC) in the sera of Gambian children with acute malaria and a positive direct anti-globulin test (DAT) was demonstrated by two methods: IgG quantitation using 125I-labelled anti-IgG and phagocytosis of these SIRBC. A similar antibody could not be demonstrated in sera of children with acute malaria and a negative DAT. When a laboratory strain of parasite was used there was a more variable pattern of IgG uptake but the highest was from sera of immune adult Gambians and Gambian children with acute malaria and a positive DAT. The uptake of IgG by SIRBC may be a useful test to determine the specificities of antibodies against different isolates of P. falciparum.
Abdalla
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D000328:Adult; D004912:Erythrocytes / Q000276:immunology* / Q000469:parasitology; D006384:Hemagglutination; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008288:Malaria / Q000276:immunology*; D009895:Opsonin Proteins / Q000032:analysis; D010587:Phagocytosis; D010963:Plasmodium falciparum / Q000276:immunology*; D012397:Rosette Formation
D007074:Immunoglobulin G; D009895:Opsonin Proteins