title: Postprandial oscillations of plasma glucose, insulin and C-peptide in man.
abstract: Postprandial plasma glucose, insulin and C-peptide profiles were studied in eight normal subjects, in the afternoon or in the evening. Two to five synchronous oscillations, with a mean period of 51 to 112 min were detected. The oscillations were highest after meals and were then damped, reverting to fasting levels after up to 340 min. Additional short-term oscillations, with periods of 20-30 min and 9-14 min, were observed. Cross-correlation studies of glucose and insulin and of insulin and C-peptide revealed a high correlation in the frequency bands considered. The synchronous oscillations of insulin and C-peptide suggest cyclic variations in pancreatic secretion rather than cyclic changes in insulin degradation.
authors.affiliation: Service de Médecine Interne CHU Hautepierre, Strasbourg, France.
authors.forename: C
authors.initials: C
authors.lastname: Simon
authors.forename: M
authors.initials: M
authors.lastname: Follenius
authors.forename: G
authors.initials: G
authors.lastname: Brandenberger
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002096:C-Peptide / Q000097:blood*; D004435:Eating; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D009991:Oscillometry; D012016:Reference Values; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin