Decreased superoxide dismutase-2 activity in a patient with ring chromosome 6.
Manganese superoxide dismutase (SOD-2) activity was measured in erythrocytes and leukocytes of a patient with ring chromosome 6. Compared to normal control individuals, SOD-2 activity in leukocytes of the patient was lower, whereas cuprozinc SOD (SOD-1) activity was normal. These findings suggest the cause of decreased enzyme activity is the effect of the ring form on production of the enzyme or inherent instability of ring chromosomes.
Yoshimitsu
K
K
Department of Pediatrics, Hiroshima University School of Medicine, Japan.
Nishi
Y
Y
Kobayashi
Y
Y
Yoshimura
O
O
Ohama
K
K
Oguma
N
N
Usui
T
T
D001827:Body Height; D002648:Child; D002869:Chromosome Aberrations; D002896:Chromosomes, Human, Pair 6 / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007621:Karyotyping; D009030:Mosaicism; D012303:Ring Chromosomes; D013482:Superoxide Dismutase / Q000097:blood*
D013482:Superoxide Dismutase