Genetic recombination between closely linked makers of bacteriophage T4. IV. Mutations which interfere with mismatch repair.
T4 phage mutations MCO1 and MCO3 reduced recombination between multiple closely linked markers preferentially and were located between gene 24 and gene 25. The MCO1 and the MCO3 mutants complemented each other. The results of UV-cross reactivation experiments indicated that the MCO1 and the MCO3 mutants could rescue the markets of UV-damaged phage, but could not segregate them from flanking mutations. Therefore, it is concluded that MCO1 mutation and MCO3 mutation interfere with mismatch repair.
Honda
M
M
Department of Molecular Biology, University of Tokyo, Japan.
D003433:Crosses, Genetic; D004260:DNA Repair; D004926:Escherichia coli / Q000235:genetics*; D009154:Mutation; D011995:Recombination, Genetic; D013045:Species Specificity; D013604:T-Phages / Q000235:genetics*; D013696:Temperature