Comparison of two sucralfate dosages presented in tablet form in duodenal ulcer healing.
Two hundred twenty-two patients with endoscopically proven duodenal ulcers participated in a controlled trial to assess and compare the effects of two dosage regimens of sucralfate tablets on ulcer healing, i.e., 1 g four times daily (group A, n = 131) and 2 g twice daily (group B, n = 128). Healing was defined as complete re-epithelialization. Clinical and endoscopic assessments were performed after four weeks (Day 28) and, if complete healing was not achieved, after four more weeks (Day 56). After four weeks, in group A (n = 114: eight patients were lost and nine were withdrawn), the ulcers had healed in 90 patients (79 percent), and in group B (n = 108: six patients were lost and 14 were withdrawn), the ulcers had healed in 80 patients (74 percent). The cumulative healing rates after eight weeks were 94 percent in group A and 95 percent in group B. No serious adverse effect was observed in either group. These results suggest that sucralfate tablets in a dosage of 2 g twice daily are as effective as 1 g four times daily in the treatment of acute duodenal ulcers and could lead to better patient compliance.
Coste
T
T
Department of Gastroenterology, Hospital Avicenne, Bobigny, France.
Rautureau
J
J
Beaugrand
M
M
Delas
N
N
Glikmanas
M
M
Gouffier
E
E
Henry-Biabaud
E
E
Latrive
J P
JP
Launois
J P
JP
Libeskind
M
M
D000328:Adult; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000473:pathology; D004384:Duodenoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011897:Random Allocation; D012907:Smoking; D013392:Sucralfate / Q000008:administration & dosage* / Q000627:therapeutic use; D013607:Tablets
D013607:Tablets; D013392:Sucralfate