[Intra-arterial chemotherapy in advanced ovarian cancer. 2. Technic, results, complications].
Between 1978 and 1984 43 patients with advanced ovarian carcinomas got intra-arterially MTX and 5-FU after being operated, later they received systemically a CMFV chemotherapy (therapy arm A). 42 patients were treated systemically only with a CMFV combination. The results and complications of both types of treatment were evaluated according to theoretical and technical basis of the intraarterial infusion. The intra-arterial chemotherapy led to a significant better rate of remission (74 per cent in therapy arm A compared with 62 per cent in therapy arm B) because of a rapid induction of remission. The cumulative survival time was significantly extended to 27 months compared with 16 months after systemic therapy only.
Lotze
W
W
Richter
P
P
Sarembe
B
B
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D008727:Methotrexate / Q000008:administration & dosage; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D011897:Random Allocation; D014747:Vinblastine / Q000008:administration & dosage
D014747:Vinblastine; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate
Intraarterielle Chemotherapie bei fortgeschrittenen Ovarialkarzinomen 2. Mitteilung: Technik, Ergebnisse, Komplikationen.