Effect of immunization with Escherichia coli K1 antigen on the course of experimental infection of the urinary tract of the rat.
The influence of vaccination with an immunogenic K1 antigen of Escherichia coli on the course of pyelonephritis induced experimentally in rats by infection with Escherichia coli O2:K1:H4 was investigated. The immunogenic properties of K1 antigen are poor. A conjugate of K1 antigen with bovine serum albumin (BSA) was therefore tested. Preliminary experiments showed that the K1-BSA conjugate is immunogenic. Renal inflammatory activity in rats after retrograde infection was significantly reduced after vaccination of the animals with K1-BSA conjugate within six weeks of infection.
Straube
E
E
Institute of Microbiology, Medical School of the Wilhelm Pieck University, Rostock, GDR.
Nimmich
W
W
Broschewitz
U
U
Naumann
G
G
Hacker
K
K
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000942:Antigens, Bacterial; D016667:Bacterial Capsules; D001428:Bacterial Vaccines / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology; D004927:Escherichia coli Infections / Q000276:immunology*; D022361:Escherichia coli Vaccines; D005260:Female; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D012710:Serum Albumin, Bovine / Q000276:immunology; D014552:Urinary Tract Infections / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D022361:Escherichia coli Vaccines; D011135:Polysaccharides, Bacterial; C036962:capsular polysaccharide K1; D012710:Serum Albumin, Bovine