Chromosomal analysis of bladder cancer. III. Nonrandom alterations.
Chromosome analysis using G- and C-banding was performed on 13 primary transitional cell carcinomas of the bladder. The chromosome preparations were obtained by a direct method. In eight tumors with a (near) diploid modal chromosome number, the most frequently observed chromosome aberrations were: (partial) monosomy 9 in four cases, deletion of 10q in two cases, and partial trisomy 1 in two cases. In five tumors with a modal chromosome number in the triploid or tetraploid range the chromosomes #1, #3, #7, #9, #11, and #17 were numerically and or structurally abnormal in at least four cases. In three out of ten males, the Y chromosome was missing. These findings suggest that the loss of chromosome #9, and possibly also loss of 10q is a primary event in the karyotypic evolution of transitional cell carcinoma of the bladder.
Smeets
W
W
Stichting Ziekenhuisapotheek en Klinisch Laboratorium, Venray, The Netherlands.
Pauwels
R
R
Laarakkers
L
L
Debruyne
F
F
Geraedts
J
J
D002295:Carcinoma, Transitional Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D011003:Ploidies; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
D005819:Genetic Markers