Prevention of nephrotoxic cyclosporine peak concentrations by daily drug division in 3 equal oral portions.
Nephrotoxicity is the main side effect of cyclosporine therapy. In this study 2 groups consisting of 6 kidney transplant recipients were investigated. The oral cyclosporine daily dose was in the first group 13 mg/kg, in the second 11 mg/kg, respectively. In both groups, the daily dose was divided on the first day of investigation in 2 equal portions given at an interval of 12 hours. On the second day, the same dose was divided in 3 equal portions given at an interval of 8 hours. After cyclosporine administration twice a day very high blood cyclosporine peak concentrations (two to three times higher than the therapeutic range) were measured. These potential nephrotoxic cyclosporine concentrations could be prevented by cyclosporine application in 3 equal portions. A reduction of the daily dose in the early period after kidney transplantation to a starting daily dose of 12 mg/kg or even 10 mg/kg can be recommended.
Zazgornik
J
J
Schindler
J
J
Balcke
P
P
Kopsa
H
H
Gremmel
F
F
Derfler
K
K
Kretschmer
G
G
Mühlbacher
F
F
Piza
F
F
D000328:Adult; D003524:Cyclosporins / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D004334:Drug Administration Schedule; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D016030:Kidney Transplantation; D007700:Kinetics; D008875:Middle Aged
D003524:Cyclosporins