Angiotensin II-induced contraction of mesangial cells in acute renal artery stenosis in dogs.
1. Renal artery stenosis was induced in anaesthetized dogs, and the kidney rapidly fixed after 30 min. 2. Electron microscopy revealed marked folding of the paramesangial basement membrane in stenotic kidneys (n = 7). The extent of this folding was significantly less in dogs treated with captopril (n = 6). 3. It is suggested that this folding reflects angiotensin II-induced contraction of the mesangial cells, which may help maintain glomerular filtration rate following stenosis.
Anderson
W P
WP
Baker Medical Research Institute, Victoria, Australia.
Alcorn
D
D
Gilchrist
A I
AI
Ryan
G B
GB
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002216:Captopril / Q000494:pharmacology; D004285:Dogs; D005920:Glomerular Mesangium / Q000473:pathology*; D007672:Kidney Cortex / Q000648:ultrastructure; D008854:Microscopy, Electron; D012078:Renal Artery Obstruction / Q000473:pathology*
D000804:Angiotensin II; D002216:Captopril