title: Dose-response relationship in the treatment of idiopathic thrombocytopenic purpura with intravenous immunoglobulin.
abstract: The dose-response relationship in the intravenous immunoglobulin treatment of idiopathic thrombocytopenic purpura was studied in 20 adult patients in a multicenter prospective crossover trial. The rate of response increases from 3 out of 11 (27%) to 6 out of 10 treatment periods (60%) by raising the 7S-IgG dose given on 5 consecutive days from 164.50 +/- 24.55 to 359.65 +/- 58.62 mg/kg body weight. The onset and duration of response as well as the peak platelet count were found to be independent of the doses. A long-term benefit induced by intravenous immunoglobulin treatment could be achieved in 2 out of 14 patients with chronic idiopathic thrombocytopenic purpura.
authors.forename: B
authors.initials: B
authors.lastname: Emmerich
authors.forename: E
authors.initials: E
authors.lastname: Hiller
authors.forename: F
authors.initials: F
authors.lastname: Woitinas
authors.forename: P A
authors.initials: PA
authors.lastname: Maubach
authors.forename: H
authors.initials: H
authors.lastname: Riess
authors.forename: C
authors.initials: C
authors.lastname: Nerl
authors.forename: R G
authors.initials: RG
authors.lastname: Geursen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010976:Platelet Count / Q000187:drug effects; D011696:Purpura, Thrombocytopenic / Q000628:therapy*
chemical_list: D007074:Immunoglobulin G