Adrenoceptors in the kidney: localization and pharmacology.
The kidney plays a key role in the regulation of blood pressure. The sympathetic nervous system can influence many aspects of kidney function in relation to blood pressure control, e.g. renal vascular tone, intrarenal renin release and tubular reabsorption of electrolytes and fluid. The intrarenal distribution of adrenoceptors has now been studied on the basis of modern receptor ligand binding techniques combined with microscopic studies. The preferential localization of each adrenoceptor subtype within the kidney is reviewed. Furthermore, an attempt is made to describe the functional correlation of the presence of different adrenoceptor subtypes. Finally, the possible role of renal adrenoceptor abnormalities in the pathogenesis of hypertension is discussed.
Struyker-Boudier
H A
HA
Dept. of Pharmacology, University of Limburg, Maastricht, The Netherlands.
Janssen
B J
BJ
Smits
J F
JF
D000818:Animals; D001692:Biological Transport; D002395:Catecholamines / Q000096:biosynthesis; D006973:Hypertension / Q000209:etiology; D007668:Kidney / Q000294:innervation* / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D009129:Muscle Tonus; D011941:Receptors, Adrenergic / Q000378:metabolism / Q000502:physiology*; D012079:Renal Circulation; D012083:Renin / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000033:anatomy & histology; D014018:Tissue Distribution; D014666:Vasomotor System / Q000502:physiology
D002395:Catecholamines; D011941:Receptors, Adrenergic; D012083:Renin