title: The effect of small doses of guanfacine (Estulic Sandoz) on the lipid levels and catecholamine excretion in patients with essential hypertension.
abstract: During three-month therapy with small doses of guanfacine (Estulic Sandoz) that were sufficient to control blood pressure in patients with stage II essential hypertension and led to a decrease in excretion of noradrenaline and vanillylmandelic acid, the authors found a decrease in the level of blood cholesterol in patients with hyperlipidaemia. There was no adverse effect on the levels of triglycerides, beta, pre-beta and alpha lipoproteins. The authors conclude that Estulic therapy is indicated in patients who, in addition to essential hypertension, have hyperlipidaemia.
authors.affiliation: First Medical Department, Comenius University Faculty of Medicine, Bratislava, Czechoslovakia.
authors.forename: I
authors.initials: I
authors.lastname: Balazovjech
authors.forename: D
authors.initials: D
authors.lastname: Skultétyová
authors.forename: M
authors.initials: M
authors.lastname: Mikulecký
authors.forename: H
authors.initials: H
authors.lastname: Kratochvíl'ová
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000652:urine*; D002784:Cholesterol / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D016316:Guanfacine; D006146:Guanidines / Q000008:administration & dosage*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D010648:Phenylacetates / Q000008:administration & dosage*; D014280:Triglycerides / Q000097:blood
chemical_list: D000959:Antihypertensive Agents; D002395:Catecholamines; D006146:Guanidines; D008055:Lipids; D008074:Lipoproteins; D010648:Phenylacetates; D014280:Triglycerides; D016316:Guanfacine; D002784:Cholesterol