Cytotoxic and antitumor activity of a soluble fraction of Streptococcus pyogenes against S180 sarcoma cells.
A fraction (60F) having cytotoxic and antitumor activities was obtained from cell-free extract of group A Streptococcus pyogenes by precipitating with 50% to 60% saturated ammonium sulfate. 60F showed cytotoxic activity inhibiting the uptake of 3H-thymidine by S180 sarcoma cells and enhancing 51Cr-release from 51Cr-labeled cells. 60F showed also antitumor activity, depressing tumor growth and prolonging lives of mice bearing S180 sarcoma cells.
Higuchi
Y
Y
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents; D003602:Cytotoxicity, Immunologic; D007167:Immunotherapy; D051379:Mice; D012513:Sarcoma, Experimental / Q000628:therapy*; D013297:Streptococcus pyogenes / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents