Reduction of endoscopically assessed acute aspirin-induced gastric mucosal injury with cimetidine.
We studied the influence of cimetidine on the gastroscopically visible effects of a single 1296-mg dose of aspirin. An initial dose-response study in 48 subjects showed that 200- and 400-mg doses of cimetidine conferred a sufficient reduction in gastric mucosal injury to warrant further study. A second study showed that coadministration of a single 200- or 400-mg cimetidine tablet with the aspirin conferred the same degree of injury reduction as when cimetidine was given before the aspirin. Reduction in mucosal injury by a 200-mg cimetidine tablet, coadministered with four aspirin tablets, was then compared to placebo in a double-blind trial. A reduction of mucosal injury was observed in 14 of 20 (70%) subjects receiving cimetidine and 0 of 10 subjects receiving placebo (P less than 0.001). Two hundred milligrams of cimetidine is therefore a rational dose for further studies of the reduction of chronic aspirin-induced gastric mucosal injury.
Kimmey
M B
MB
Silverstein
F E
FE
Saunders
D R
DR
Chapman
R C
RC
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D002927:Cimetidine / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005753:Gastric Mucosa / Q000473:pathology*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D008297:Male; D011897:Random Allocation; D013272:Stomach Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology
D002927:Cimetidine; D001241:Aspirin