[Monoclonal antibodies in pigmented lesions].
We have applied a battery of murine monoclonal antibodies (R-24, L-101, S-171) to the immunohistological diagnosis of 35 pigmented lesions. The results of our study allow us to conclude that: 1) The monoclonal antibody R-24 is a good marker of normal and neoplastic melanocytes, although some melanomas do not stain with this monoclonal antibody. The application of R-24 may contribute to the pathologic differential diagnosis of melanoma metastases. 2) The association of R-24+ and L-101+ staining is found in melanocytic nevus as well as in melanomas, and do not allow the differential diagnosis between them. 3) Stains with R-24, L-101 and S-171 are simultaneously positive only in melanomas, and with low frequency.
Puig
L
L
Servicio de Anatomía Patológica, Hospital de "San Pablo", Barcelona.
Moreno
A
A
Moragas
J M
JM
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D003937:Diagnosis, Differential; D006801:Humans; D008545:Melanoma / Q000473:pathology* / Q000556:secondary; D009508:Nevus, Pigmented / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000954:Antigens, Surface
Anticuerpos monoclonales en lesiones pigmentadas.