[Current problems in the theory of regulation of enzymes and enzyme systems].
The kinetic fundamentals of enzyme and enzymatic system regulation are discussed. The use of modern computers for analysis and modeling of the process is a qualitatively new approach to studies in this field at the present stage. Basic biokinetic equations, regularities and kinetic specific features of the processes in multienzymatic systems are considered. The kinetic behaviour of a multienzymatic system for prostacyclin and thromboxane synthesis is analyzed by way of example. The capacity of the system for maintaining constant concentrations of these physiologically active substances is shown to be its most valuable characteristic. The problems and prospects of developing a quantitative theory of enzyme and enzymatic system regulation are scrutinized.
Varfolomeev
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SD
D000818:Animals; D004798:Enzymes / Q000378:metabolism*; D011464:Epoprostenol / Q000096:biosynthesis; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000378:metabolism; D013931:Thromboxanes / Q000096:biosynthesis
D004798:Enzymes; D009097:Multienzyme Complexes; D013931:Thromboxanes; D011464:Epoprostenol
Sovremennye problemy teorii reguliatsii fermentov i fermentnykh sistem.