Identification of an interleukin HP1-like plasmacytoma growth factor produced by L cells in response to viral infection.
We have recently purified and partially sequenced a new T cell-derived lymphokine with growth factor activity for B cell hybridomas and plasmacytomas, which we named interleukin HP1 (HP1). Here we show that, in response to viral infection or after treatment with poly(rI).poly(rC), L cells produce a factor that is capable of supporting the in vitro growth and survival of HP1-dependent cell lines. Serologic and structural evidence is presented in favor of the identity between the fibroblast factor and HP1, demonstrating that non-T cells can make HP1-related molecules.
Cayphas
S
S
International Institute of Cellular and Molecular Pathology, Université Catholique de Louvain, Brussels, Belgium.
Van Damme
J
J
Vink
A
A
Simpson
R J
RJ
Billiau
A
A
Van Snick
J
J
D000818:Animals; D001681:Biological Assay; D001688:Biological Products / Q000502:physiology*; D002455:Cell Division; D016207:Cytokines; D006133:Growth Substances / Q000502:physiology*; D015850:Interleukin-6; D007378:Interleukins / Q000502:physiology*; D007526:Isoelectric Point; D007739:L Cells / Q000502:physiology*; D051379:Mice; D010954:Plasmacytoma / Q000473:pathology; D011070:Poly I-C / Q000494:pharmacology; D014777:Virus Diseases / Q000503:physiopathology*
D001688:Biological Products; D016207:Cytokines; D006133:Growth Substances; D015850:Interleukin-6; D007378:Interleukins; D011070:Poly I-C