Calcium antagonists and the ischemic myocardium.
Recent laboratory studies have shown that the calcium antagonists (slow channel blockers) can protect the myocardium against the consequences of experimentally induced ischemia and reperfusion. With one recent exception, however, clinical trials relating to the effectiveness of these drugs in the management of patients with myocardial infarction have been disappointing. This paper explores this apparent discrepancy.
Nayler
W G
WG
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000188:drug therapy* / Q000473:pathology; D003331:Coronary Vessels / Q000187:drug effects; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy; D009206:Myocardium / Q000648:ultrastructure
D002121:Calcium Channel Blockers