title: Failure of high dose mebendazole as a microfilaricide in patients with loiasis.
abstract: The effectiveness of mebendazole as a microfilaricide in patients with loiasis was studied. The drug regimen was 1 g twice daily for 21 days in adults. During and after treatment, the microfilarial density was unchanged. Therefore, mebendazole has no direct effect on the microfilarial density of Loa loa.
authors.affiliation: Laboratoire de Recherches, Albert Schweitzer Hospital, Lambarene, Gabon.
authors.forename: G D
authors.initials: GD
authors.lastname: Burchard
authors.forename: P
authors.initials: P
authors.lastname: Kern
mesh_terms: D002986:Clinical Trials as Topic; D005368:Filariasis / Q000188:drug therapy*; D006801:Humans; D008118:Loiasis / Q000188:drug therapy*; D008463:Mebendazole / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D008463:Mebendazole