[Metabolic function of the lungs and regulation of homeostasis].
Morphological, biochemical and pathophysiological data on the significance of the metabolic (non-respiratory) function of the lungs in the regulation of homeostasis have been summarized. The key "strategic" position of the lungs in the blood circulation system, the concentration of a unique set of biochemical regulatory factors in the lung endothelium, as well the presence of a multiple system of nervous and humoral control ensure the realization of a specific mission by lungs as a regulator of the functional integrity of the organism. The lungs serve as a barrier controlling the passage of deleterious substances into arterial blood and consequently into the brain and other organs and at the same time the lungs are responsible for the controlled synthesis and elimination of physiologically active substances essential for the work of the same systems. These functions attain special significance under stress-induced situations as a result of homeostatic disruptions and as a consequence of grave extrapulmonary injuries. The author's concept on a compensatory function of the lung kallikrein-kinin system under extreme conditions of organism is given. This pathway opens up the prospects for search of ways of correcting functional disruption in organism.
Gomazkov
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OA
D006706:Homeostasis; D006801:Humans; D007610:Kallikreins / Q000502:physiology; D007705:Kinins / Q000502:physiology; D008168:Lung / Q000378:metabolism* / Q000502:physiology
D007705:Kinins; D007610:Kallikreins
Metabolicheskaia funktsiia legkikh i reguliatsiia gomeostaza.