A repetitive sequence element 3' of the human c-Ha-ras1 gene has enhancer activity.
Efficient expression of the human c-Ha-ras1 gene requires sequences 3' of those specifying the polyadenylation of its transcripts. These sequences can stimulate the expression of heterologous genes in a manner largely independent of position and orientation, arguing that they possess a transcriptional enhancing activity that regulates the c-Ha-ras1 promoter. As this element is associated with a repetitive domain that is highly polymorphic, it is possible that the activity of this enhancer is variable within the human population.
Cohen
J B
JB
Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080.
Walter
M V
MV
Levinson
A D
AD
D000123:Acetyltransferases / Q000235:genetics; D015500:Chloramphenicol O-Acetyltransferase; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D011905:Genes, ras; D005822:Genetic Vectors; D006801:Humans; D010957:Plasmids; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D014158:Transcription, Genetic; D014162:Transfection
D000123:Acetyltransferases; D015500:Chloramphenicol O-Acetyltransferase