DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes.
We sequenced the 5'-coding region of the human c-src gene, exons 2 through 5, corresponding to one-third of the human c-src protein consisting of 536 amino acids. Sequence analysis of the src type of protein kinases revealed that the amino-terminal region encoded by exon 2 contains sequences specific for the src proteins and raised the possibility that this region is involved in the recognition of a src-specific substrate(s) or receptor(s).
Tanaka
A
A
Gibbs
C P
CP
Arthur
R R
RR
Anderson
S K
SK
Kung
H J
HJ
Fujita
D J
DJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002645:Chickens; D005796:Genes; D006801:Humans; D007438:Introns; D009857:Oncogenes; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012326:RNA Splicing; D012689:Sequence Homology, Nucleic Acid
D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases