[Disorders in the thrombocyte link of hemostasis during endotoxinemia and their correction with the inhibitor of prostaglandin biosynthesis, indomethacin].
After 10 minutes of endotoxin Salmonella typhimurium (1 mg/kg) injection into rabbits thrombocytopenia appeared, the aggregation and secretory function of circulating platelets reduced, the transformation of platelet forms from disk-shaped into spheroidal took place. On the surface of plasmatic membranes the pseudopodies and aggregates examining samples of PRP were observed. Indomethacin, blockator of biosynthesis of prostaglandins results in normalisation of morphofunctional properties of platelets.
Pak
S G
SG
Sinel'nikova
M P
MP
Tsukerman
D B
DB
Neliubov
M V
MV
Belikov
D V
DV
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism / Q000648:ultrastructure; D004705:Endocytosis / Q000187:drug effects; D004731:Endotoxins; D007213:Indomethacin / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D012486:Salmonella typhimurium; D013920:Thrombocythemia, Essential / Q000097:blood* / Q000209:etiology
D004731:Endotoxins; D007213:Indomethacin
Narusheniia v trombotsitarnom zvene gemostaza pri éndotoksinemii i korrektsiia ikh ingibitorom biosinteza prostaglandinov, indometatsinom.