Comparison of live and inactivated influenza vaccine in high risk children.
Bivalent, live attenuated intranasally administered influenza A vaccines were compared to inactivated, parenterally administered influenza A vaccines in a double-blind clinical trial in 55 children and young adults with cystic fibrosis. No qualitative or quantitative difference in symptomatology between the group receiving intranasal live vaccine versus placebo was observed. Serum immune responses to live vaccines were somewhat less than those to inactivated vaccine, particularly in adults. IgA response in nasal secretions was minimal in each vaccine group. In contrast, an IgG response in nasal secretions was commonly seen with both topically applied live vaccine and parenterally administered inactivated vaccine.
King
J C
JC
Vanderbilt University School of Medicine, Nashville, TN 37232.
Gross
P A
PA
Denning
C R
CR
Gaerlan
P F
PF
Wright
P F
PF
Quinnan
G V
GV
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003550:Cystic Fibrosis / Q000150:complications; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007223:Infant; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D007273:Injections, Intramuscular; D010919:Placebos; D012306:Risk; D014613:Vaccines, Attenuated
D007252:Influenza Vaccines; D010919:Placebos; D014613:Vaccines, Attenuated