title: Parasympathetic denervation hypersensitivity of the iris in ocular hypertension.
abstract: Seventy-eight ocular hypertensive patients and 47 age-and sex-matched control subjects were assessed for parasympathetic denervation hypersensitivity of the iris using topical application of 2.5% methacholine chloride solution. Constriction of the pupil in response to methacholine stimulation of the sphincter pupillae was significantly greater in the ocular hypertensive patients than the control group (P less than 0.001). The implications are discussed, with particular reference to the association between autonomic neuropathy and the primary glaucomas.
authors.affiliation: Glaucoma Unit, St. Paul's Eye Hospital, Liverpool, United Kingdom.
authors.forename: C V
authors.initials: CV
authors.lastname: Clark
authors.forename: R
authors.initials: R
authors.lastname: Mapstone
mesh_terms: D000287:Administration, Topical; D000368:Aged; D003714:Denervation; D005260:Female; D006801:Humans; D007498:Iris / Q000294:innervation* / Q000503:physiopathology; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000008:administration & dosage; D008875:Middle Aged; D009798:Ocular Hypertension / Q000503:physiopathology*; D010275:Parasympathetic Nervous System / Q000503:physiopathology*; D011680:Pupil / Q000187:drug effects / Q000503:physiopathology
chemical_list: D008688:Methacholine Compounds; D016210:Methacholine Chloride