title: Neural-specific carbohydrate moiety shared by many surface glycoproteins in Drosophila and grasshopper embryos.
abstract: Antiserum against horseradish peroxidase (anti-HRP Ab) labels the surfaces of neurons in both Drosophila and grasshopper (Jan and Jan, 1982). Here we show that the anti-HRP Ab (1) immunoprecipitates at least 17 different membrane glycoproteins from the Drosophila embryo CNS (and a similar array from grasshopper), and (2) recognizes a neural-specific carbohydrate moiety expressed by most if not all of these proteins. Although the anti-HRP Ab stains all axon pathways, 2 of the anti-HRP glycoproteins, fasciclin I and II, are expressed on specific subsets of axon pathways in the grasshopper embryo.
authors.affiliation: Department of Biological Sciences, Stanford University, California 94305.
authors.forename: P M
authors.initials: PM
authors.lastname: Snow
authors.forename: N H
authors.initials: NH
authors.lastname: Patel
authors.forename: A L
authors.initials: AL
authors.lastname: Harrelson
authors.forename: C S
authors.initials: CS
authors.lastname: Goodman
mesh_terms: D000818:Animals; D000906:Antibodies; D002241:Carbohydrates / Q000032:analysis*; D015816:Cell Adhesion Molecules, Neuronal; D004330:Drosophila; D004625:Embryo, Nonmammalian; D005455:Fluorescent Antibody Technique; D006023:Glycoproteins / Q000032:analysis*; D006110:Grasshoppers; D006735:Horseradish Peroxidase; D008562:Membrane Glycoproteins / Q000032:analysis; D009474:Neurons / Q000032:analysis*
chemical_list: D000906:Antibodies; D002241:Carbohydrates; D015816:Cell Adhesion Molecules, Neuronal; D006023:Glycoproteins; D008562:Membrane Glycoproteins; C051641:fasciclin I; C051642:fasciclin II; D006735:Horseradish Peroxidase