title: Cerebellar hemangioblastoma with prominent stromal astrocytosis: diagnostic and histogenetic considerations.
abstract: A cerebellar hemangioblastoma with atypical radiologic and morphologic features is reported. On computed tomography this tumor presented as a single ring-enhancing mass in the right cerebellar hemisphere without adjacent cyst formation. It was radiologically indistinguishable from an abscess or malignant neoplasm. Postmortem examination demonstrated a circumscribed, cystic neoplasm arising in the pia at the base of a sulcus. Microscopically, the tumor contained a prominent astrocytic component that mimicked the appearance of a highly vascular astrocytoma. Hemangioblastomas with this degree of astrocytosis are unusual. They must be distinguished pathologically from both cystic astrocytoma and mixed hemangioblastoma-glioma (angioglioma).
authors.affiliation: Department of Pathology, University of Nebraska Medical Center, Omaha 68105.
authors.forename: R D
authors.initials: RD
authors.lastname: McComb
authors.forename: P J
authors.initials: PJ
authors.lastname: Eastman
authors.forename: F J
authors.initials: FJ
authors.lastname: Hahn
authors.forename: D R
authors.initials: DR
authors.lastname: Bennett
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001253:Astrocytes / Q000473:pathology*; D002528:Cerebellar Neoplasms / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology; D003937:Diagnosis, Differential; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006394:Hemangiosarcoma / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D014057:Tomography, X-Ray Computed
chemical_list: D005904:Glial Fibrillary Acidic Protein