title: Primary leiomyosarcoma of bone. A case report and review of the literature.
abstract: A 62-year-old female with primary leiomyosarcoma of the left femur is reported with a review of 21 cases reported in the literature. The resected specimen showed that the tumor extended from the femoral head to the diaphysis for 13 cm in length. The tumor showed mainly intramedullary proliferation, but extraosseous growth was also noted at the great trochanter. Microscopic examination revealed well differentiated leiomyosarcoma characterized by interlacing bundles of fusiform cells with eosinophilic cytoplasm and rod-shaped hyperchromatic nuclei. PAP stain of actin on the tumor cells was positive. On electron microscopy, microfilament of 6-8 nm in diameter, dense bodies, pinocytotic vesicles, marginal attachment plate, and basal lamina were noted. The patient died with pulmonary metastasis, 1 year and 7 months after the operation. An autopsy showed metastases in the right pelvic cavity and bilateral lungs, and confirmed the primary site to be the left femur.
authors.forename: N
authors.initials: N
authors.lastname: Kameda
authors.forename: M
authors.initials: M
authors.lastname: Kagesawa
authors.forename: N
authors.initials: N
authors.lastname: Hiruta
authors.forename: M
authors.initials: M
authors.lastname: Akima
authors.forename: M
authors.initials: M
authors.lastname: Ohki
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
mesh_terms: D005260:Female; D005266:Femoral Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007124:Immunoenzyme Techniques; D007890:Leiomyosarcoma / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged