title: Regional chromosomal assignment of human renin gene to 1q12----qter and use in linkage studies in Charcot-Marie-Tooth disease.
abstract: The gene for renin, previously mapped to human chromosome 1, was further localized to 1q12----qter using human-mouse somatic cell hybrid DNAs. The renin DNA probe used (lambda HR5) could detect a HindIII restriction fragment length polymorphism. When used in studies of 12 informative families, no linkage could be found between the renin gene and Charcot-Marie-Tooth disease. Furthermore, an association of any renin allele with hypertension was not apparent.
authors.affiliation: Department of Medicine, University of Sydney, Australia.
authors.forename: L R
authors.initials: LR
authors.lastname: Griffiths
authors.forename: G A
authors.initials: GA
authors.lastname: Nicholson
authors.forename: D A
authors.initials: DA
authors.lastname: Ross
authors.forename: M B
authors.initials: MB
authors.lastname: Zwi
authors.forename: J G
authors.initials: JG
authors.lastname: McLeod
authors.forename: T
authors.initials: T
authors.lastname: Mohandas
authors.forename: B J
authors.initials: BJ
authors.lastname: Morris
mesh_terms: D000818:Animals; D002607:Charcot-Marie-Tooth Disease / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology; D008297:Male; D051379:Mice; D009134:Muscular Atrophy, Spinal / Q000235:genetics*; D010375:Pedigree; D012083:Renin / Q000235:genetics*
chemical_list: D012083:Renin