title: Effect of sustained release terbutaline on symptoms and sleep quality in patients with nocturnal asthma.
abstract: The effect of an oral sustained release beta 2 agonist on symptoms, sleep quality, and peak flow rates has been studied in nine patients with nocturnal asthma. Patients received oral terbutaline 7.5 mg twice daily or placebo for seven days in a double blind crossover study and spent the last two nights of each limb in a sleep laboratory. Oral terbutaline improved morning peak flow (259 v 213 l min-1) and decreased nocturnal inhaler usage (1.3 v 1.9) with no alteration in sleep quality as assessed electroencephalographically. The study shows that oral sustained release terbutaline can be useful in the treatment of nocturnal asthma without impairment of sleep quality.
authors.affiliation: Department of Respiratory Medicine, University of Edinburgh, City Hospital.
authors.forename: I C
authors.initials: IC
authors.lastname: Stewart
authors.forename: G B
authors.initials: GB
authors.lastname: Rhind
authors.forename: J T
authors.initials: JT
authors.lastname: Power
authors.forename: D C
authors.initials: DC
authors.lastname: Flenley
authors.forename: N J
authors.initials: NJ
authors.lastname: Douglas
mesh_terms: D000284:Administration, Oral; D000368:Aged; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D012890:Sleep / Q000187:drug effects*; D013726:Terbutaline / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D003692:Delayed-Action Preparations; D013726:Terbutaline