Antibiotic usage in pelvic infections. An overview.
Postoperative soft-tissue pelvic infections in women most commonly are polymicrobial and mixed aerobic and anaerobic. Antibiotic prophylaxis has been advocated to reduce the risk of postcesarean endometritis and post-vaginal hysterectomy pelvic infection. The use of antibiotic prophylaxis has a tendency to select for resistant bacteria, and many of those bacteria produce beta-lactamase. A new approach to the treatment of those infections is to employ beta-lactamase inhibitors in conjunction with a broad-spectrum antibiotic, such as ticarcillin disodium plus clavulanate potassium (Timentin).
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Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000517:prevention & control*; D002511:Cephalosporins / Q000627:therapeutic use*; D005260:Female; D005831:Genital Diseases, Female / Q000517:prevention & control*; D006801:Humans; D011247:Pregnancy; D011292:Premedication; D011644:Puerperal Disorders / Q000517:prevention & control; D013530:Surgical Wound Infection / Q000517:prevention & control; D065093:beta-Lactamase Inhibitors
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D065093:beta-Lactamase Inhibitors