title: Chromogranin A is present in and released by fish endocrine tissue.
abstract: Chromogranin A (CgA) is a protein that is present in many mammalian endocrine cells and co-secreted with their resident hormones. We have demonstrated the presence of CgA by immunohistology in the ultimobranchial glands and corpuscles of Stannius of rainbow trout. CgA was also detected by radioimmunoassay in the medium of incubated coho salmon ultimobranchial glands. Our observations demonstrate the presence of CgA in endocrine glands of evolutionarily divergent species. These observations are consistent with the hypothesis that CgA participates in the secretory process of a wide variety of hormones.
authors.forename: L J
authors.initials: LJ
authors.lastname: Deftos
authors.forename: B T
authors.initials: BT
authors.lastname: Björnsson
authors.forename: D W
authors.initials: DW
authors.lastname: Burton
authors.forename: D T
authors.initials: DT
authors.lastname: O'Connor
authors.forename: D H
authors.initials: DH
authors.lastname: Copp
mesh_terms: D000818:Animals; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism*; D004702:Endocrine Glands / Q000378:metabolism*; D006651:Histocytochemistry; D007124:Immunoenzyme Techniques; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism; D011863:Radioimmunoassay; D012474:Salmon / Q000378:metabolism*; D012487:Salmonidae / Q000378:metabolism*; D014337:Trout / Q000378:metabolism*; D014460:Ultimobranchial Body / Q000378:metabolism
chemical_list: D053379:Chromogranin A; D002864:Chromogranins; D009419:Nerve Tissue Proteins