Cyclosporin alters the induction of allospecific tolerance in vivo.
CBA mice were made hyporesponsive to A/J alloantigens by either neonatal inoculation of (CBA X A)F1 hybrid lymphoid cells or by intravenous injection of adult mice with A/J bone marrow cells. Specific alloreactivity was assessed in vitro by induction of anti-A/J cytotoxic T lymphocytes (CTL) or in vivo by skin graft rejection. Cyclosporin A given at the same time as the tolerance-inducing regimen of F1 (or parental) lymphoid cells abolished the hyporesponsiveness normally induced by these injections.
Gorczynski
R M
RM
Department of Surgery, University of Toronto, Mount Sinai Research Institute, Ont., Canada.
Holmes
W
W
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D016026:Bone Marrow Transplantation; D003524:Cyclosporins / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D007108:Immune Tolerance / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology
D003524:Cyclosporins