Augmentation of chemically induced pancreatic and bronchial cancers by epidermal growth factor.
The incidence of Syrian golden hamsters with pancreatic cancer induced by subcutaneous injections of N-nitroso-bis(2-oxopropyl)amine for 19 weeks (each 10 mg/kg) increased from 44% to 75% (p=0.016) when epidermal growth factor was also administered from week 5 through week 8 (5 mug energy three days for injections). Epidermal growth factor increased pancreatic weight and body weight. The incidence of animals with bronchial cancer doubled. Epidermal growth factor could be a cocarcinogen as a result of its mitogenic activity.
Malt
R A
RA
Surgical Services, Shriners Burns Institute, Mass
Chester
J F
JF
Gaissert
H A
HA
Ross
J S
JS
D000818:Animals; D001984:Bronchial Neoplasms / Q000139:chemically induced*; D002273:Carcinogens; D003043:Cocarcinogenesis; D006224:Cricetinae; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005260:Female; D008647:Mesocricetus; D009602:Nitrosamines; D010190:Pancreatic Neoplasms / Q000139:chemically induced*
D002273:Carcinogens; D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine; D004815:Epidermal Growth Factor