Evidence for an activated subpopulation of T8-bearing cells in male homosexuals with lymphadenopathy.
Data are presented that male homosexuals with chronic lymphadenopathy and reduced numbers of T4-antigen-bearing cells have an increased incidence of activated T8-antigen-bearing cells. Evidence suggesting an increase in activated T cells in these subjects includes an increase in incidence of T10-antigen-bearing cells, an increase in Ia-bearing T cells and an increase in the intensity of staining of a fraction of the T8-antigen-bearing cells with fluorescein-labeled OKT8 monoclonal antibody. It was shown by double staining that most of the Ia-bearing T cells also bore the T8 marker. The heterogeneity of the Ia, assayed by reactivity with several monoclonal anti-Ia antibodies which detect different epitopes on the Ia molecule, was comparable in lymphadenopathy subjects and controls.
Hillman
J
J
Russo
C
C
Weksler
M E
ME
Siskind
G W
GW
D000386:AIDS-Related Complex / Q000276:immunology*; D000328:Adult; D000954:Antigens, Surface / Q000032:analysis; D002478:Cells, Cultured; D004261:DNA Replication; D005455:Fluorescent Antibody Technique; D006716:Homosexuality; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology
D000954:Antigens, Surface