[Oral galactose loading in characterizing the elimination and metabolizing performance of the liver in chronic renal failure].
For characterising the elimination and metabolisation performance of the liver in chronic renal insufficiency the galactose load test was carried out. 9 children with healthy liver and kidneys, 35 children with chronic renal insufficiency (15 were conservatively treated = group 1, 20 were in the chronic haemodialysis programme = group 2) as well as 5 children after kidney transplantation were examined. In group 1 a normal blood galactose concentration was present. Patients of the 2nd group showed increased concentrations of galactose in the blood which might refer to a decreased redox potential in the liver caused by the uraemic intoxication. In the group of patients who underwent a kidney transplantation in the patients with azathioprine therapy a disturbed use of galactose was present. Children with cyclosporin-A had a normal galactose concentration.
Otting
U
U
Eggert
S
S
Eggert
W
W
Zoellner
K
K
Buchali
K
K
D000284:Administration, Oral; D002648:Child; D005260:Female; D005690:Galactose / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D016030:Kidney Transplantation; D008099:Liver / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D008657:Metabolic Clearance Rate; D011183:Postoperative Complications / Q000378:metabolism; D006435:Renal Dialysis
D005690:Galactose
Die orale Galaktosebelastung zur Charakterisierung der Eliminations- und Metabolisierungsleistung der Leber bei chronischer Niereninsuffizienz.