Pulmonary "cyclosporinoma" mimicking infection after heart transplantation.
Tissue from a transthoracic needle biopsy, which was performed as part of the investigation of an undiagnosed left upper lobe opacity in a patient after orthotopic heart transplantation, revealed numerous macrophages loaded with oil globules. No causative organisms were present. High-pressure liquid chromatography showed a similar profile to the oil in which cyclosporine is suspended. The lesion appears to have been caused by aspiration of cyclosporine.
Gould
K
K
Department of Cardiothoracic Surgery, University of Newcastle upon Tyne, England.
Freeman
R
R
Odom
N J
NJ
Locke
T J
TJ
McGregor
C G
CG
D000328:Adult; D003524:Cyclosporins / Q000009:adverse effects*; D003937:Diagnosis, Differential; D016027:Heart Transplantation; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging; D008297:Male; D011015:Pneumonia, Aspiration / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D011183:Postoperative Complications / Q000139:chemically induced*; D011859:Radiography
D003524:Cyclosporins