Mucociliary clearance in early simple chronic bronchitis.
Tracheobronchial mucociliary clearance was measured in 37 patients with early simple chronic bronchitis. A non-invasive radio-aerosol technique with inhalation of 99Tcm labelled 5-microns polystyrene particles followed by assessment of radio-nuclide distribution by posterior gamma-camera scans was employed. The mucociliary clearance of the bronchitics was significantly lower than clearance of a non-smoker control group. An interim analysis of the effect of treatment with a surfactant stimulating drug, ambroxol, suggested a dosage-dependent tendency to a faster mucociliary clearance than seen in placebo-treated bronchitics.
Dirksen
H
H
Dept. of Clinical Physiology, Finsen Institute/Rigshospitalet, Copenhagen, Denmark.
Hermansen
F
F
Groth
S
S
Mølgaard
F
F
D000328:Adult; D000551:Ambroxol / Q000627:therapeutic use; D001980:Bronchi / Q000378:metabolism*; D001991:Bronchitis / Q000188:drug therapy / Q000378:metabolism*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D006801:Humans; D009079:Mucociliary Clearance / Q000187:drug effects
D000551:Ambroxol