title: Multipoint mapping studies of six loci on chromosome 11.
abstract: The six loci, beta-globin (HBBC), parathyroid hormone (PTH), oncogene c-Ha-ras-1 (HRAS1), insulin (INS), calcitonin (CAL) and catalase (CAT) loci, have been mapped to 11p in the order: CAT-CAL-PTH-HBBC-(HRAS1-INS). The purpose of the current study was to examine the linkage relationships, especially the multipoint relationships of these loci in detail. In the 18 families studied, a significant sex difference in recombination was found for the HBBC: HRAS1 linkage with more recombination in the male parent than the female parent (22 vs. 2%). The results of the multipoint analyses provided further evidence for the order CAT-CAL-PTH-HBBC-(HRAS1-INS); however, the order of the last two tightly linked loci is still not clear.
authors.forename: D A
authors.initials: DA
authors.lastname: Meyers
authors.forename: T H
authors.initials: TH
authors.lastname: Beaty
authors.forename: N E
authors.initials: NE
authors.lastname: Maestri
authors.forename: S D
authors.initials: SD
authors.lastname: Kittur
authors.forename: S E
authors.initials: SE
authors.lastname: Antonarakis
authors.forename: H H
authors.initials: HH
authors.lastname: Kazazian
mesh_terms: D002116:Calcitonin / Q000235:genetics; D002374:Catalase / Q000235:genetics; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D005260:Female; D008040:Genetic Linkage; D005914:Globins / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000235:genetics; D008297:Male; D009857:Oncogenes; D010281:Parathyroid Hormone / Q000235:genetics; D011995:Recombination, Genetic; D012737:Sex Factors
chemical_list: D007328:Insulin; D010281:Parathyroid Hormone; D005914:Globins; D002116:Calcitonin; D002374:Catalase