[Development of drug resistance in cases of P. falciparum malaria of African origin in a Parisian hospital. Comparison with field data and therapeutic consequences].
The number of P. falciparum malaria cases, contracted in Africa, diagnosed by the department of Parasitology and Tropical diseases of the Pitié-Salpêtrière Hospital Group has shown a significant increase in 1985-1986 when compared with the 15 past years (+23%). This fact is related to the spread of chloroquine or amodiaquine resistant falciparum malaria from East Africa (1980-1983: 54%) to Central Africa (1985: 54.5%) and now to a country of west Africa (Benin 1986).
Danis
M
M
Service de Parasitologie-Médecine tropicale, Hôpital Pitié-Salpêtrière, Paris.
Rosenheim
M
M
Druilhe
P
P
Brandicourt
O
O
Datry
A
A
Brasseur
P
P
Brucker
G
G
Duflo
B
B
Gentilini
M
M
D000349:Africa; D000655:Amodiaquine / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D002738:Chloroquine / Q000627:therapeutic use; D004338:Drug Combinations; D004351:Drug Resistance; D005602:France; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine; D013413:Sulfadoxine; D014195:Travel
D000962:Antimalarials; D004338:Drug Combinations; D000655:Amodiaquine; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D002738:Chloroquine; D011739:Pyrimethamine
Evolution de la chimiorésistance des cas de paludisme a P. falciparum d'origine africaine dans un hôpital parisien. Comparaison avec les données observées sur le terrain et conséquences thérapeutiques.