title: A clinical trial of a monocomponent pertussis toxoid vaccine.
abstract: We compared a monocomponent pertussis toxoid vaccine preparation (JNIH-7) in a double-blind, randomized study with another component vaccine (JNIH-6) containing pertussis toxoid and filamentous hemagglutinin in equal proportions. Monocomponent pertussis toxoid vaccines have not been tested previously in children. This trial comprised 255 previously nonimmunized children 6 to 10 months old who were given two 0.5-mL subcutaneous injections of either vaccine four to five weeks apart. Prevaccination and postvaccination serum samples from 235 infants showed an antitoxin seroconversion rate of 100% in both groups. Adverse reactions were few and mild, with local reactions occurring more often after administration of the second dose and among recipients of the two-component vaccine (P less than .05).
authors.forename: S
authors.initials: S
authors.lastname: Hedenskog
authors.forename: M
authors.initials: M
authors.lastname: Granström
authors.forename: P
authors.initials: P
authors.lastname: Olin
authors.forename: M
authors.initials: M
authors.lastname: Tiru
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
mesh_terms: D000917:Antibody Formation; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D006801:Humans; D007223:Infant; D010567:Pertussis Vaccine / Q000009:adverse effects / Q000276:immunology*; D011897:Random Allocation; D014611:Vaccination / Q000009:adverse effects
chemical_list: D010567:Pertussis Vaccine