The effects of soluble Saccharomyces cerevisiae mannan on the phagocytosis of Candida albicans by mouse peritoneal macrophages in vitro.
Saccharomyces cerevisiae mannan inhibited the phagocytic activity and phagocytic capacity of mouse peritoneal macrophages elicited by Concanavalin A (Con A) for Candida albicans yeast cells that were either unopsonized or opsonized with C3. The mannan had no effect on the phagocytosis of C. albicans opsonized with normal human serum or immunoglobulins. Phagolysosome fusion in macrophages was unimpaired by the presence of S. cerevisiae mannan, which supports previous observations that mannan does not interfere with neutrophil degranulation.
Kolotila
M P
MP
Rogers
A L
AL
Beneke
E S
ES
Smith
C W
CW
D000818:Animals; D002176:Candida albicans / Q000276:immunology*; D003176:Complement C3 / Q000502:physiology; D007111:Immunity, Cellular; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D008351:Mannans / Q000276:immunology / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D010587:Phagocytosis / Q000187:drug effects*; D010588:Phagosomes; D012441:Saccharomyces cerevisiae / Q000276:immunology*
D003176:Complement C3; D008351:Mannans