title: Effects of extracellular osmolality on renin release and on the ultrastructure of the juxtaglomerular epithelioid cell granules.
abstract: Superfusion with hypoosmotic solutions stimulates renin release from rat epithelioid cells adherent to isolated glomeruli. This stimulatory effect may be related to the observed swelling of the secretory granules; the swelling may markedly increase the probability of pre-exocytotic fusions between the granule and cell membranes, and consequently increase the frequency of exocytotic events.
authors.forename: O
authors.initials: O
authors.lastname: Skøtt
authors.forename: R
authors.initials: R
authors.lastname: Taugner
mesh_terms: D000818:Animals; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D004848:Epithelium / Q000201:enzymology / Q000648:ultrastructure; D005110:Extracellular Space / Q000502:physiology; D007606:Juxtaglomerular Apparatus / Q000201:enzymology* / Q000648:ultrastructure; D007700:Kinetics; D008297:Male; D008854:Microscopy, Electron; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000378:metabolism*
chemical_list: D012083:Renin