Monosomy 7 predisposes to diabetes insipidus in leukaemia and myelodysplastic syndrome.
We studied the chromosomes in the bone marrow of 4 patients who had both diabetes insipidus (DI) and acute non-lymphocytic leukaemia. Clinical findings suggested that, in each case, myelodysplastic syndrome had preceded the onset of acute leukaemia. Two other such patients described in the literature had had a banded karyotype study of bone marrow cells. All 6 patients had deletions of chromosome 7. 3 had monosomy 7 as the sole cytogenetic abnormality, 2 had monosomy 7 associated with other clonal abnormalities and 1 had del(7)(q22) in association with other abnormalities. These data suggest that monosomy 7 or perhaps monosomy for 7q22-qter predisposes to DI. The mechanism by which the proposed predisposition is produced remains to be clarified.
de la Chapelle
A
A
Department of Medical Genetics, University of Helsinki, Finland.
Lahtinen
R
R
D000208:Acute Disease; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D002999:Clone Cells / Q000648:ultrastructure; D003919:Diabetes Insipidus / Q000209:etiology* / Q000235:genetics; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000235:genetics*; D014411:Neoplastic Stem Cells / Q000648:ultrastructure