Syndromes of acute nonlymphocytic leukemia.
The marriage of cytogenetics and molecular biology has resulted in major advances in our understanding of acute nonlymphocytic leukemia. These technologies reveal a number of clearly recognizable syndromes of acute nonlymphocytic leukemia. This review describes the salient features of several of these syndromes: acute myelomonocytic leukemia with abnormal eosinophils; acute nonlymphocytic leukemia with 11q abnormalities [biphenotypic leukemia with t(4;11); and acute monocytic leukemia with t(9;11)]; acute nonlymphocytic leukemia with t(8;21); acute promyelocytic leukemia; acute nonlymphocytic leukemia with normal or elevated platelet counts and rearranged 3q21 and 3q26; and acute nonlymphocytic leukemia with increased basophils and t(6;9). The pathogenesis of therapy-related leukemias is discussed also.
Koeffler
H P
HP
Department of Medicine, UCLA School of Medicine.
D000208:Acute Disease; D001491:Basophils; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D004804:Eosinophils; D006801:Humans; D007938:Leukemia / Q000097:blood / Q000139:chemically induced / Q000145:classification* / Q000209:etiology / Q000235:genetics; D015470:Leukemia, Myeloid, Acute / Q000097:blood; D010976:Platelet Count; D011878:Radiotherapy / Q000009:adverse effects