Mathematical model of Klebsiella pneumoniae resistance to amikacin and gentamicin.
1. The resistance of Klebsiella pneumoniae to amikacin and gentamicin was studied by a mathematical model to predict the rate of sensitivity decrease. The results accurately matched experimental data, showing that the model is a reliable predicting tool. 2. The observations were carried out over six years and included 2677 cultures that were positive for K. pneumoniae. At the beginning of the observation period, 85.7% of the cultures were sensitive to amikacin and 40.8% were sensitive to gentamicin. Sensitivity to amikacin showed a surprisingly rapid decrease; at the end of the experimental period, amikacin and gentamicin sensitivities were 33.3% and 27.8%, respectively. 3. We conclude that patterns of resistance of other bacteria could be investigated using this method.
Nicolelis
M A
MA
Departamento de Patologia e Hospital das Clínicas, Faculdade de Medicina, Universìdade de São Paulo, Brasil.
Massad
E
E
Hutzler
R U
RU
Engel
A
A
Rodrigues
E
E
Bazzone
J C
JC
Tomida
M
M
D000583:Amikacin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology*; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008962:Models, Theoretical
D005839:Gentamicins; D000583:Amikacin