[Treatment of neuro-meningeal listeriosis in patients over 60 with a combination of ampicillin and trimethoprim-sulfamethoxazole].
An open retrospect study, including five patients, has been entered on, in order to estimate the efficacity and the tolerance in a more than sixty years old person, of the association ampicillin-cotrimoxazole for the treatment of the meningitis due to Listeria monocytogenes. In the infectious sphere, all the patients recovered; one death, by pulmonary embolism at the 21sh day of evolution, is to be deplored; two erythematous rashes have been observed. These preliminary results are encouraging and incite to carry on the evaluation of this protocol, which could replace the classical therapy; ampicillin-aminoglycosides, where only the ampicillin reaches effective concentrations on the level in the cerebro-spinal fluid.
Becq-Giraudon
B
B
Breux
J P
JP
D000368:Aged; D000667:Ampicillin / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008584:Meningitis, Listeria / Q000188:drug therapy*; D008875:Middle Aged; D012189:Retrospective Studies; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D004338:Drug Combinations; D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole
Traitement des listérioses neuro-méningées du sujet âgé de plus de soixante ans par l'association ampicilline + sulfaméthoxazole triméthoprime.