[Antithrombin III. Functional role and methods of determination (review)].
Antithrombin III (AT III) is the most important inhibitor of thrombin and other serine proteinases in the system of blood coagulation. AT III not only removes the excess of thrombin from blood but it inhibits the enzyme synthesis. AT III became functionally active in presence of heparin, which operates as a catalyst and accelerates significantly the formation of inactive complexes between AT III and proteinases, which usually developed slowly in absence of the activator. AT III and heparin cofactor are synonyms and designate the same substance. Modern procedures for estimation of AT III in blood plasma are reviewed.
Belitser
V A
VA
Musialkovskaia
A A
AA
Platonova
T N
TN
Ena
Ia M
IaM
D000990:Antithrombin III / Q000032:analysis / Q000502:physiology*; D006801:Humans
D000990:Antithrombin III
Antitrombin III. Funktsional'naia rol' i metody opredeleniia (obzor).