Does colchicine work? The results of the first controlled study in acute gout.
We have performed the first controlled study of colchicine in acute gout, to determine its efficacy and toxicity, and to define the natural history of acute gout. Two-thirds of colchicine-treated patients improved after 48 hours, but only one-third of the patients receiving placebo demonstrated similar improvement. The colchicine-treated patients responded earlier; significant differences from placebo were shown after 18-30 hours. All patients given colchicine developed diarrhea after a median time of 24 hours (mean dose of colchicine 6.7 mg). This side effect occurred before relief of pain in most patients.
Ahern
M J
MJ
Department of Medicine, Flinders University of South Australia.
Reid
C
C
Gordon
T P
TP
McCredie
M
M
Brooks
P M
PM
Jones
M
M
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002986:Clinical Trials as Topic; D003078:Colchicine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006073:Gout / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement
D003078:Colchicine