[Problematic aspects of placebo-controlled double-blind studies with highly effective drugs such as etretinate].
Highly potent drugs should be studied by means of double placebo experiments rather than by semi-blind trials. In semi-blind trials, possible side effects induced by the placebo might not be sufficiently registered, and those induced by the verum cannot be adequately evaluated.
Schwanitz
H J
HJ
D002986:Clinical Trials as Topic; D003876:Dermatitis, Atopic / Q000188:drug therapy; D004311:Double-Blind Method; D005050:Etretinate / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy; D006229:Hand Dermatoses / Q000188:drug therapy; D006801:Humans; D008297:Male; D012871:Skin Diseases / Q000188:drug therapy*
D005050:Etretinate
Zur Problematik Placebo-kontrollierter Doppelblind-studien mit hochwirksamen Medikamenten wie Etretinat.