Lymphoid stromal reaction in gastrointestinal lymphomas: immunohistochemical study of 14 cases.
The lymphoid stromal reaction, particularly the T lymphoid reaction, was studied immunohistochemically on cryostat sections in 14 cases of primary gastrointestinal B lymphomas, and compared with the type and distribution of lymphoid cells in three cases of gastric lymphoid hyperplasia. A pronounced T lymphoid reaction, mainly of the T helper phenotype, occurred in both lesions. Most of these T cells bore HLA-DR antigens, but only a few of them had the receptor for interleukin 2. The T lymphoid reaction was observed inside the lymphomas in seven of a total of 14 cases, and around the lymphomas in four of the six cases clinically classified as stage I. Perivascular mucosal and submucosal nodules, entirely composed of T cells, seemed characteristic of gastric lymphoid hyperplasias. A T lymphoid reaction in lymphoid hyperplasias suggests an amplification of the cell mediated immune response; in lymphomas it could represent a host reaction against the lymphomatous infiltrate, therefore favouring a better prognosis.
Jarry
A
A
Brousse
N
N
Souque
A
A
Barge
J
J
Molas
G
G
Potet
F
F
D001402:B-Lymphocytes / Q000276:immunology; D005770:Gastrointestinal Neoplasms / Q000276:immunology / Q000473:pathology*; D006684:HLA-DR Antigens / Q000032:analysis; D006644:Histiocytes / Q000276:immunology; D006801:Humans; D006965:Hyperplasia; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000032:analysis; D007958:Leukocyte Count; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000473:pathology*; D013270:Stomach / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology
D006684:HLA-DR Antigens; D007136:Immunoglobulins