Induction of SOS functions in Escherichia coli and biosynthesis of nitrosamine in rabbits by nitrogen dioxide.
Nitrogen dioxide induced SOS functions in Salmonella typhimurium and Escherichia coli K-12 and was mutagenic in Escherichia coli WP2. When a rabbit was administered aminopyrine intravenously and administered nitrogen dioxide by inhalation, N-nitrosodimethylamine was detected in its blood. Analysis was conducted with 15N-nitrosodimethylamine as an internal standard by a combination of capillary gas chromatography and mass spectrometry. Accompanying administration of cystamine increased the blood concentration of N-nitrosodimethylamine in the rabbit, suggesting inhibition of its metabolism. Concurrent sulfur trioxide inhalation increased N-nitrosodimethylamine formation in the rabbit.
Kosaka
H
H
Division of Environmental Health Research, Osaka Prefectural Institute of Public Health, Japan.
Uozumi
M
M
Nakajima
T
T
D000632:Aminopyrine / Q000378:metabolism; D000818:Animals; D001711:Biotransformation; D003538:Cystamine / Q000494:pharmacology; D004260:DNA Repair / Q000187:drug effects*; D004128:Dimethylnitrosamine / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D007700:Kinetics; D009154:Mutation; D009585:Nitrogen Dioxide / Q000378:metabolism / Q000494:pharmacology*; D009602:Nitrosamines / Q000378:metabolism*; D009876:Operon; D010957:Plasmids; D011817:Rabbits; D013014:SOS Response, Genetics / Q000187:drug effects*
D009602:Nitrosamines; D000632:Aminopyrine; D004128:Dimethylnitrosamine; D003538:Cystamine; D009585:Nitrogen Dioxide