title: Optic nerve hypoplasia.
abstract: Optic nerve hypoplasia is an easily overlooked, nonprogressive developmental anomaly which results in a wide range of visual deficits. It is frequently associated with clinically significant central nervous system and endocrine abnormalities. Maternal substance abuse is increasingly recognized in many cases. A supranormal regression of optic nerve axons in utero, rather than a primary failure of differentiation, is proposed as the pathogenesis.
authors.affiliation: Department of Ophthalmology, University of California, San Francisco.
authors.forename: S R
authors.initials: SR
authors.lastname: Lambert
authors.forename: C S
authors.initials: CS
authors.lastname: Hoyt
authors.forename: M H
authors.initials: MH
authors.lastname: Narahara
mesh_terms: D006801:Humans; D009900:Optic Nerve / Q000002:abnormalities*; D013577:Syndrome; D014786:Vision Disorders / Q000151:congenital*