Secretion of LH in spontaneously hypertensive rats.
Weights of testes, seminal vesicles, ventral prostate and pituitary, plasma testosterone and LH concentrations, pituitary LH content and concentration, the LH in-vivo response after LHRH administration (1 microgram), and basal and LHRH-stimulated secretion in vitro were analysed in adult male spontaneously hypertensive (SH) and normotensive control (WKY) rats. Spontaneously hypertensive rats showed: testis and pituitary hypertrophy; seminal vesicle and ventral prostate atrophy; increased plasma testosterone and LH concentrations; increased pituitary LH content and concentration; unchanged net increase of plasma concentrations of LH 15 and 45 min after administration of 1 microgram LHRH; and increased basal LH secretion in vitro with a normal response to LHRH stimulation. These results provide evidence that SH rats show increased LH secretion with a normal response to LHRH stimulation. The coexistence of high plasma concentrations of testosterone with seminal vesicle and ventral prostate atrophy suggest a reduction in the effectiveness of testosterone in these structures.
Rodriguez-Padilla
M
M
Bellido
C
C
Pinilla
L
L
Aguilar
E
E
D000818:Animals; D005837:Genitalia, Male / Q000473:pathology; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006973:Hypertension / Q000503:physiopathology*; D066298:In Vitro Techniques; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D010902:Pituitary Gland / Q000187:drug effects / Q000473:pathology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013739:Testosterone / Q000097:blood
D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone