Characterization of motor activity patterns induced by N-methyl-D-aspartate antagonists in gerbils.
A computerized motor activity data collection and analysis system is described. An example of the utilization of the Digiscan system is provided, in which motor activity patterns induced by three N-methyl-D-aspartate (NMDA) antagonists and the dissociative anesthetic, ketamine, are compared. All of these compounds produce a distinct pattern of motor activity characterized by an increase in distance traveled, movement time, speed and perimeter walking, with a decrease in vertical activity. Recently described links between NMDA and phencyclidine (PCP) binding sites may account for these findings. The utility of computerized motor activity apparatus is clearly demonstrated.
Boast
C A
CA
Neuroscience Research, CIBA-Geigy Corp., Summit, NJ 07901.
Pastor
G
G
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000596:Amino Acids / Q000009:adverse effects / Q000494:pharmacology; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D001330:Electronic Data Processing; D005260:Female; D005849:Gerbillinae; D007649:Ketamine / Q000009:adverse effects / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D016202:N-Methylaspartate; D010875:Pipecolic Acids; D010879:Piperazines / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D013997:Time Factors
D000596:Amino Acids; D010875:Pipecolic Acids; D010879:Piperazines; D010880:Piperidines; D001224:Aspartic Acid; C053672:selfotel; D016202:N-Methylaspartate; D007649:Ketamine; D015763:2-Amino-5-phosphonovalerate; C050592:3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid; C031231:2-amino-7-phosphonoheptanoic acid