title: [Determination of blood ceftriaxone. Comparison of microbiological and HPLC methods].
abstract: 108 serum samples in 27 patients were collected after the first, before the second, after and before the fifth dose of 2 g every 24 h and assayed for ceftriaxone by microbiological method and high pressure liquid chromatography (HPLC). The statistical analysis of the results show a correlation coefficient equal to 0.95. The protein binding doesn't affect the microbiological method. The two methods are convenient for clinical use.
authors.affiliation: Laboratoire de Bactériologie, Hôpital Pellegrin, Bordeaux.
authors.forename: B
authors.initials: B
authors.lastname: de Barbeyrac
authors.forename: F
authors.initials: F
authors.lastname: Penouil
authors.forename: J J
authors.initials: JJ
authors.lastname: Gardère
authors.forename: M C
authors.initials: MC
authors.lastname: Saux
authors.forename: A
authors.initials: A
authors.lastname: Brachet-Liermain
authors.forename: C
authors.initials: C
authors.lastname: Bebear
mesh_terms: D001431:Bacteriological Techniques; D002443:Ceftriaxone / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D006801:Humans
chemical_list: D002443:Ceftriaxone
vernacular_title: Dosage sérique de la ceftriaxone. Comparaison des méthodes par microbiologie et CLHP.