Re-examination of the effect of either a lateral or third ventricular cannula on captopril-induced salt appetite in rats.
In Study A, rats were implanted with a cannula aimed at either the lateral (LV) or ventral third (V3V) brain ventricles 1 week prior to starting a chronic oral regimen of captopril. The presence of neither cannula significantly impaired the emergence of captopril-induced appetite for NaCl solution. In Study B, V3V cannulae were implanted in rats after a captopril-induced appetite for NaCl was established. The surgery produced a 1-2 day attenuation of NaCl intake, but this was no greater than that observed in a sham-operated group that received no cannula. These results do not support those of others who suggest that captopril (and, by inference, other agents) can leak across a damaged blood-brain barrier for at least 2 weeks after placement of a cannula. Possible reasons for the differences in results are addressed.
Rowland
N E
NE
Department of Psychology, College of Liberal Arts and Science, University of Florida, Gainesville 32611.
Fregly
M J
MJ
D000284:Administration, Oral; D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects*; D002216:Captopril / Q000008:administration & dosage*; D002408:Catheters, Indwelling; D002552:Cerebral Ventricles / Q000502:physiology* / Q000601:surgery; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000502:physiology*
D012965:Sodium Chloride; D002216:Captopril