title: Anaphylactoid and anti-ovulatory activities of LHRH antagonists in rats.
abstract: Studies were conducted with LHRH antagonists examining the relationship of structure to anaphylactoid-like activity and the relationship of anaphylactoid-like activity to anti-ovulatory activity in rats. Substitution of basic amino acids appeared to enhance the anaphylactoid-like activity of these peptides but other complex structural characteristics may also be involved. Anaphylactoid and anti-ovulatory activities were clearly independent and potent LHRH antagonists with minimal anaphylactoid-like activity were identified.
authors.affiliation: Research Laboratories, Ortho Pharmaceutical Corp., Raritan, NJ 08869.
authors.forename: A
authors.initials: A
authors.lastname: Phillips
authors.forename: D W
authors.initials: DW
authors.lastname: Hahn
authors.forename: R J
authors.initials: RJ
authors.lastname: Capetola
authors.forename: C
authors.initials: C
authors.lastname: Bishop
authors.forename: J L
authors.initials: JL
authors.lastname: McGuire
mesh_terms: D000595:Amino Acid Sequence; D000707:Anaphylaxis / Q000139:chemically induced*; D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D010060:Ovulation / Q000187:drug effects*; D011359:Proestrus; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
chemical_list: D007987:Gonadotropin-Releasing Hormone