[Short-term clinical and histological evaluation of combination drug therapy of leprosy in Mayotte].
Leprosy in Mayotte affects 480 persons in a population of 80,000 inhabitants. 229 patients have been treated every day by association of Rifampicin, Clofazimine and Isoniazide. This study make a clinical, histological and bacteriological valuation after treatment, during a period of 3 years. With paucibacillary patients, whom received 1 year of mean treatment and after 2 years under observation, histology for short-dated can stay positive and active. With multibacillary patients, whom received 26 months of mean treatment and most of the time after 1 year under observation, the all of morphological index is negative, sometime bacteriology is positive, less often than histology. For middle- and long-dated, histology should allow a good valuation for disease evolution, specially for interpolar leprosy patients.
Cnudde
F
F
Julvez
J
J
Rivière
J P
JP
D002991:Clofazimine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007195:Indian Ocean Islands; D007538:Isoniazid / Q000627:therapeutic use*; D007918:Leprosy / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D012293:Rifampin / Q000627:therapeutic use*
D002991:Clofazimine; D007538:Isoniazid; D012293:Rifampin
Evaluation clinique et histologique à court terme de la polychimiothérapie contre la lèpre à Mayotte.