Metabolism of phthalidyl theophylline in rat liver.
Phthalidyl theophylline (PH-TH) in rat liver was metabolized by a hydrolase to theophylline (TH) and 2-carboxybenzaldehyde, and the latter was further metabolized to 2-hydroxymethylbenzoic acid by an nicotinamide adenine dinucleotide-dependent reductase. The hydrolase could be strongly inhibited by acetazolamide, therefore, urinary excretion of PH-TH metabolites was significantly retarded when PH-TH and acetazolamide were coadministered to rats. The results from in vivo experiments suggest that PH-TH was efficiently absorbed from the gastrointestines and metabolized extensively by the liver.
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D000086:Acetazolamide / Q000494:pharmacology; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000818:Animals; D006867:Hydrolases / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility; D013806:Theophylline / Q000031:analogs & derivatives* / Q000378:metabolism; D014867:Water
D014867:Water; C052722:phthalidyltheophylline; D013806:Theophylline; D000429:Alcohol Oxidoreductases; C051107:2-carboxybenzaldehyde reductase; D006867:Hydrolases; C052723:phthalidyltheophylline hydrolase; D000086:Acetazolamide