Localization of Ro (SS-A) antigen in the cardiac conduction system.
The presence of anti-Ro (SS-A) antibody in maternal serum has been associated with congenital heart block. Using human sera monospecific for anti-Ro (SS-A) antibodies in an indirect immunofluorescence assay, Ro (SS-A) antigen was found to be present in the nuclei of myocardial cells and cells of the cardiac conduction system. The possible relationship between the location of Ro (SS-A) antigen, anti-Ro (SS-A) antibody, and heart block is discussed.
Deng
J S
JS
Department of Dermatology, Verterans Administration Medical Center, Pittsburgh, PA 15240.
Bair
L W
LW
Shen-Schwarz
S
S
Ramsey-Goldman
R
R
Medsger
T
T
D001324:Autoantigens / Q000032:analysis* / Q000276:immunology; D002802:Cholinesterases / Q000378:metabolism; D005318:Fetal Heart / Q000276:immunology / Q000473:pathology*; D005455:Fluorescent Antibody Technique; D005865:Gestational Age; D006327:Heart Block / Q000276:immunology*; D006329:Heart Conduction System / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007106:Immune Sera / Q000032:analysis; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen
D001324:Autoantigens; D002802:Cholinesterases; D007106:Immune Sera; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human