Effect of folate on phenytoin hyperplasia.
There have been some reports that folic acid inhibits phenytoin-induced gingival hyperplasia. The purpose of this double-blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin-induced gingival overgrowth in man. For a period of 6 months, one group of phenytoin patients received 2 daily topical applications of a folate solution. An additional group received 2 daily doses of systemic folate while a control group received placebo medication. Results indicate that throughout the 180-day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.
Drew
H J
HJ
Vogel
R I
RI
Molofsky
W
W
Baker
H
H
Frank
O
O
D000284:Administration, Oral; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002648:Child; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage*; D005885:Gingival Hyperplasia / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*; D011897:Random Allocation; D013607:Tablets
D013607:Tablets; D010672:Phenytoin; D005492:Folic Acid