Synthesis and antifungal activity of new 1-vinylimidazoles.
Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III. Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imidazole transfer reaction, were alkylated to furnish the title compounds V. The structure-activity relationships of these 1-vinylimidazole compounds V are described.
Ogata
M
M
Matsumoto
H
H
Shimizu
S
S
Kida
S
S
Shiro
M
M
Tawara
K
K
D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003022:Clotrimazole / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014249:Trichophyton / Q000187:drug effects; D014753:Vinyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology
D007093:Imidazoles; D014753:Vinyl Compounds; D003022:Clotrimazole