title: [Cytotoxic antibodies in multiple sclerosis].
abstract: Serum cold cytotoxic activities against allocells: total lymphocytes, B lymphocytes and monocytes were detected in 12 of 21 multiple sclerosis (MS) patients at 15 degrees C using a microcytotoxicity technique. Cytotoxic activity was found at 37 degrees C in certain MS patients. This activity was weak or absent in non MS patients and in healthy controls. Tests with autocells were positive in 6 MS patients. Cerebrospinal fluid cytotoxic activity was found in MS as well as in non-MS diseases; at 37 degrees C CSF produced lysis of monocytes in the absence of complement. No correlation was found between cytotoxic activity and parameters of clinical disease. Our results suggest that there may be a wide variety of cytotoxic antibodies in MS. Their significance is unknown; it may be that they have an effect on certain lymphocyte subsets as it has been suggested in other diseases.
authors.forename: L
authors.initials: L
authors.lastname: Rumbach
authors.forename: M M
authors.initials: MM
authors.lastname: Tongio
authors.forename: S
authors.initials: S
authors.lastname: Mayer
authors.forename: C
authors.initials: C
authors.lastname: Marescaux
authors.forename: J M
authors.initials: JM
authors.lastname: Warter
authors.forename: M
authors.initials: M
authors.lastname: Collard
mesh_terms: D000328:Adult; D000906:Antibodies / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*
chemical_list: D000906:Antibodies
vernacular_title: Les anticorps cytotoxiques au cours de la sclérose en plaques.