title: Recurrence risk in the Angelman ("happy puppet") syndrome.
abstract: We report on two sibs with Angelman "happy puppet" syndrome. Out of 48 families reported in the literature, this is only the fourth family with affected sibs. A review of the literature shows a low but not negligible recurrence risk. Different explanations for this are discussed.
authors.affiliation: Department of Pediatrics, University Hospital, Groningen, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: Willems
authors.forename: I
authors.initials: I
authors.lastname: Dijkstra
authors.forename: O F
authors.initials: OF
authors.lastname: Brouwer
authors.forename: G P
authors.initials: GP
authors.lastname: Smit
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005684:Gait; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D007845:Laughter; D008297:Male; D009069:Movement Disorders / Q000235:genetics; D011378:Prognathism / Q000235:genetics; D012008:Recurrence; D012306:Risk; D013064:Speech Disorders / Q000235:genetics*; D013577:Syndrome