[Immunohistochemical classification of cutaneous lymphomas and pseudolymphomas].
We investigated 46 cases of cutaneous lymphoma and pseudolymphoma by immunohistochemical methods using a panel of monoclonal antibodies. Of the cutaneous T cell lymphomas, 2 did not show the classic helper phenotype but revealed a predominance of suppressor cells in one case and of immature thymocytes in the other. Cutaneous B cell lymphomas of low-grade malignancy were characterized by the presence of completely developed T zones between the B cell areas. B cell lymphomas of high-grade malignancy revealed an immunohistologically homogeneous infiltrate. Cutaneous pseudolymphomas can be classified in T cell pseudolymphomas (lymphocytic infiltration, lymphomatoid papulosis) and B cell pseudolymphomas. Lymphadenosis cutis benigna with germinal center cell differentiation was clearly distinguishable from other B cell pseudolymphomas, which are considered to comprise mainly peripheral B lymphocytes. Immunohistological methods are obviously useful in the classification of lymphoproliferative diseases of the skin and can make a contribution to increasing our understanding of them.
Smolle
J
J
Universitätsklinik für Dermatologie und Venerologie Graz.
Kaudewitz
P
P
Aberer
E
E
Torne
R
R
Burg
G
G
Kerl
H
H
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D001402:B-Lymphocytes / Q000473:pathology; D001706:Biopsy; D006801:Humans; D007124:Immunoenzyme Techniques; D008223:Lymphoma / Q000145:classification / Q000473:pathology*; D012878:Skin Neoplasms / Q000145:classification / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000954:Antigens, Surface
Immunhistochemische Klassifizierung von kutanen Lymphomen und Pseudolymphomen.