C-peptide kinetics following an intravenous glucose load in children undergoing regular hemodialysis.
Following an intravenous glucose tolerance test (iv-GTT) we investigated the relationship between glucose kinetics and c-peptide release in 15 children and adolescents requiring regular hemodialysis. Following longterm hemodialysis, we were unable to demonstrate any correction of the uremia associated disturbances of insulin metabolism and c-peptide secretion. Fasting serum levels of insulin and c-peptide remained elevated and insulin excretion prolonged. After an increase in c-peptide levels there was an accumulation throughout the study period, early c-peptide secretion was reduced. Thus in regular hemodialysis, glucose metabolism did not correlate with insulin and c-peptide kinetics. The c-peptide secretion curve is out of phase with the insulin secretion rate.
Bulla
M
M
Children's University Hospital, Münster, FRG.
Ronda-Vildosola
T
T
Hübinger
D
D
D002096:C-Peptide / Q000378:metabolism*; D002648:Child; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D007700:Kinetics; D006435:Renal Dialysis; D014511:Uremia / Q000378:metabolism / Q000503:physiopathology
D002096:C-Peptide; D007328:Insulin