title: Non-pharmacological effects of the use of microelectrophoresis and pressure ejection of drugs in combination.
abstract: Pressure ejection of physiological saline from multibarrel micropipette assemblies has been shown to selectively reduce responses of rat spinal cord neurones to electrophoretic ejection of kainate, N-methyl-aspartate and 4-methyl-homoibotenate, but not of quisqualate or L-glutamate. Reduction of response to an excitatory amino acid therefore appears to be correlated with the absence of an active transport system for that amino acid.
authors.forename: S N
authors.initials: SN
authors.lastname: Davies
authors.forename: J
authors.initials: J
authors.lastname: Church
authors.forename: D
authors.initials: D
authors.lastname: Lodge
mesh_terms: D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D004586:Electrophoresis / Q000379:methods*; D007051:Ibotenic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology; D008839:Microelectrodes; D016202:N-Methylaspartate; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009543:Nifedipine / Q000494:pharmacology; D010069:Oxadiazoles / Q000494:pharmacology; D016318:Quisqualic Acid; D051381:Rats; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*
chemical_list: D000596:Amino Acids; D010069:Oxadiazoles; D007051:Ibotenic Acid; D001224:Aspartic Acid; D016202:N-Methylaspartate; C023364:homoibotenic acid; D016318:Quisqualic Acid; D009543:Nifedipine; D007608:Kainic Acid