title: Immunohistochemical localization of gamma-aminobutyric acid- and aspartate-containing neurons in the guinea pig vestibular nuclei.
abstract: The immunohistochemical distributions of gamma-aminobutyric acid (GABA)- and aspartate-containing neurons were studied in the guinea pig vestibular nuclei using purified antisera to GABA and aspartate, respectively. Most GABA-containing neurons had small cell bodies and were scattered throughout all regions of the vestibular nuclei. The largest number of these cells was found in the medial nucleus. Intraventricular injection of colchicine markedly increased GABA-like immunoreactivity in these cell bodies. GABA-containing terminals were distributed throughout all 4 subdivisions of the nuclei, with the richest localization found around the floor of the fourth ventricle. Various sized aspartate-containing neurons were noted in the vestibular nuclei and small cells were present in the superior, medial and lateral nucleus. Medium-sized cells were observed throughout the vestibular nuclei. Giant cells in the lateral nucleus also contained aspartate and were surrounded by GABA-like immunoreactive terminals, thereby suggesting the modulation of aspartate-containing neurons by GABAergic fibers from Purkinje cells.
authors.forename: K
authors.initials: K
authors.lastname: Kumoi
authors.forename: N
authors.initials: N
authors.lastname: Saito
authors.forename: C
authors.initials: C
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000032:analysis*; D005260:Female; D006168:Guinea Pigs; D006651:Histocytochemistry; D007124:Immunoenzyme Techniques; D008297:Male; D014726:Vestibular Nuclei / Q000032:analysis* / Q000166:cytology; D005680:gamma-Aminobutyric Acid / Q000032:analysis*
chemical_list: D001224:Aspartic Acid; D005680:gamma-Aminobutyric Acid