[Comparison of the diffusion of ceftriaxone in digestive surgery after a single administration at doses of one and two grams].
Twenty patients undergoing gastrointestinal surgery were randomly allocated to receive either 1 or 2 g of ceftriaxone, a long half-life third generation cephalosporin, as a single dose intravenous prophylaxis on induction of anaesthesia. Plasma and tissue samples were taken 2 hours and analysed with an HPLC procedure. The results of plasma and tissue concentrations of ceftriaxone showed that 1 g dosage was enough for preventing the occurrence of postoperative sepsis. No adverse reaction or side-effects were recorded.
Lokiec
F
F
Boudinet
A
A
Petot
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002443:Ceftriaxone / Q000008:administration & dosage / Q000378:metabolism*; D013505:Digestive System Surgical Procedures; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011897:Random Allocation
D002443:Ceftriaxone
Comparaison de la diffusion de la ceftriaxone en chirurgie digestive après administration unique aux doses de un et deux grammes.