Partial structure of an insulin-sensitive glycophospholipid.
The structure of a glycophospholipid, which has been involved in insulin action, has been investigated using H35 cells and rat liver membranes. The present evidence indicates that this molecule contains a phosphatidyl-chiro-inositol moiety, glycosidically linked to a non-N-acetylated glucosamine. In addition, the polar head group of the lipid contains galactose, probably four residues, and a total number of three phosphates.
Mato
J M
JM
Kelly
K L
KL
Abler
A
A
Jarett
L
L
Corkey
B E
BE
Cashel
J A
JA
Zopf
D
D
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000032:analysis; D007328:Insulin / Q000494:pharmacology*; D008114:Liver Neoplasms, Experimental / Q000032:analysis; D010716:Phosphatidylinositols / Q000032:analysis*; D010738:Type C Phospholipases / Q000378:metabolism
D007328:Insulin; D010716:Phosphatidylinositols; D010738:Type C Phospholipases; D005944:Glucosamine