Lymphocytes and lymphokines in aplastic anemia: pathogenic role and implications for pathogenesis.
Clinical observations first suggested an immune basis for aplastic anemia. Laboratory studies have implicated a suppressor T lymphocyte producing molecules like gamma-interferon that inhibit hematopoiesis. Extrapolation from in vitro studies is complicated by synergy and antagonism among lymphokines and interleukins, the presence of regulators of proliferation produced by bone marrow cells, and possible differences between endogenous and exogenously administered molecules on cell growth.
Young
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NS
Clinical Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892.
Leonard
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E
Platanias
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D000741:Anemia, Aplastic / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology; D001803:Blood Transfusion; D006410:Hematopoiesis; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008222:Lymphokines / Q000276:immunology / Q000502:physiology*; D008954:Models, Biological; D015846:Monokines; D011506:Proteins / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology
D000961:Antilymphocyte Serum; D008222:Lymphokines; D015846:Monokines; D011506:Proteins