Influence of enterally administered ornithine alpha-ketoglutarate on hormonal patterns in burn patients.
Plasma concentrations of glucose, insulin, C-peptide, glucagon, cortisol and hGH were measured in burn patients (mean burn surface area 21 per cent) treated or not with ornithine alpha-ketoglutarate (OKG). An increase in basal values of glucose, insulin, C-peptide and cortisol was demonstrated in both groups, whereas hGH values diminished. OKG modified neither insulin nor hGH values 24 h after its enteral administration nor insulin levels within the first 4 h after intake. On the other hand, 60 min after enteral nutrition was restarted the hyperglycaemia observed in untreated subjects was reduced by OKG whereas a hyperinsulinism was observed in both groups. These results suggest that: (i) the anticatabolic/anabolic action of OKG in burn patients is not mediated by insulin or hGH, (ii) OKG probably induces an increase in glucose tolerance in burn patients, in whom there is a state of insulin resistance. The mechanism of this action requires further study.
Vaubourdolle
M
M
Laboratoire de Biochimie A, Hôpital Saint Antoine, Paris, France.
Cynober
L
L
Lioret
N
N
Coudray-Lucas
C
C
Aussel
C
C
Saizy
R
R
Giboudeau
J
J
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D002056:Burns / Q000188:drug therapy*; D002096:C-Peptide / Q000097:blood; D005260:Female; D005934:Glucagon / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009952:Ornithine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; C002118:ornithine alpha-ketoglutarate; D013006:Growth Hormone; D005934:Glucagon; D009952:Ornithine; D006854:Hydrocortisone