title: Glucoregulatory hormone response to insulin-induced hypoglycaemia following long-term calcium antagonism with felodipine in patients with essential hypertension.
abstract: The effect of 8 weeks' treatment with the dihydropyridine calcium antagonist felodipine on glucoregulatory hormone response following insulin-induced hypoglycaemia was evaluated in 7 patients with essential hypertension, WHO grade I-II. After an iv insulin injection (0.1 IU/kg), blood glucose decrement and nadir were similar before and during felodipine treatment. Basal glucagon, noradrenaline, adrenaline, GH and cortisol levels were unchanged, and the response to insulin-induced hypoglycaemia was similar before and during felodipine treatment. Basal plasma dopamine levels were similar and did not change during insulin-induced hypoglycaemia before and during felodipine treatment. Basal serum levels of TSH, T3 and T4 were unaltered following felodipine. In conclusion, long-term treatment with felodipine did not alter the hypoglycaemic effect of exogenous insulin, or the recovery from hypoglycaemia or the glucoregulatory hormone response to insulin-induced hypoglycaemia in patients with essential hypertension.
authors.affiliation: Department of Endocrinology, University of Lund, Malmö General Hospital, Sweden.
authors.forename: P L
authors.initials: PL
authors.lastname: Katzman
authors.forename: U L
authors.initials: UL
authors.lastname: Hulthén
authors.forename: B
authors.initials: B
authors.lastname: Hökfelt
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004837:Epinephrine / Q000097:blood; D015736:Felodipine; D005934:Glucagon / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009568:Nitrendipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009638:Norepinephrine / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D001786:Blood Glucose; D002121:Calcium Channel Blockers; D007328:Insulin; D014284:Triiodothyronine; D013972:Thyrotropin; D013006:Growth Hormone; D005934:Glucagon; D009568:Nitrendipine; D015736:Felodipine; D013974:Thyroxine; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine