title: Are Leydig cells of neural origin? Substance P-like immunoreactivity in human testicular tissue.
abstract: Using the immunocytochemical peroxidase-antiperoxidase method we observed strong and selective staining of Leydig cells after incubation of human testicular tissue with an antiserum against substance P and a slightly weaker immunoreactivity against methionine-enkephalin. These results indicate that the embryologic origin of Leydig cells may require reconsideration and also offer a new perspective for research upon the local control mechanisms of spermatogenesis.
authors.forename: W
authors.initials: W
authors.lastname: Schulze
authors.forename: M S
authors.initials: MS
authors.lastname: Davidoff
authors.forename: A F
authors.initials: AF
authors.lastname: Holstein
mesh_terms: D000328:Adult; D000368:Aged; D004744:Enkephalin, Methionine / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D036341:Intercellular Signaling Peptides and Proteins; D007985:Leydig Cells / Q000378:metabolism*; D008297:Male; D010455:Peptides / Q000378:metabolism*; D013091:Spermatogenesis; D013737:Testis / Q000166:cytology / Q000378:metabolism*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C016116:substance P-like peptides; D004744:Enkephalin, Methionine