[Drug sensitivity of malaria in a population of children in Pointe-Noire, Congo, in the first half of 1986].
The study by an isotopic semi-microtest of the sensitivity of 44 P. falciparum strains isolated from Congolese children living in Pointe-Noire demonstrated a high prevalence of chloroquine resistance and partial cross resistance to monodesethylamodiaquine. The sensitivity to quinine was high except for 3 isolates. The assay of amino-4-quinolines by H. P. L. C. on 37 subjects revealed the extent of self-treatment and drug-pressure in this population. A 3-day treatment with 25 mg/kg of chloroquine or amodiaquine in 24 subjects resulted in the disappearance of clinical symptoms in all patients and a parasitological cure on day 7 in 75%. The partial maintenance of efficacy of amino-4-quinolines in this chloroquine-resistant region implies that chloroquine and amodiaquine can be used as first choice drugs for uncomplicated acute malaria, but on condition that the levels of resistance and transmission are monitored.
Simon
F
F
Centre National de Référence de la Chimiosensibilité du Paludisme, Hôpital Claude-Bernard, Paris.
Porte
J
J
Verdier
F
F
Guigon
D
D
Drouville
C
C
Le Bras
J
J
D000293:Adolescent; D000655:Amodiaquine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use; D003223:Congo; D004351:Drug Resistance; D006801:Humans; D007223:Infant; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology*; D010963:Plasmodium falciparum / Q000187:drug effects
D000962:Antimalarials; D000655:Amodiaquine; C047386:desethylamodiaquine; D002738:Chloroquine
Chimiosensibilité du paludisme dans une population d'enfants de Pointe-Noire, Congo, au premier semestre 1986.