Successful long-term exocrine and endocrine function of the autotransplanted pancreas in humans.
Segmental pancreatic autotransplantation has been performed to prevent the severe metabolic complications of total pancreatectomy. To date 15 segmental pancreatic autotransplants have been reported, 11 of which have been performed for relief of the abdominal pain of chronic pancreatitis. The major problem with segmental pancreatic graft relates to the handling of the pancreatic duct and its secretion. In all the reported cases, the autotransplanted duct was either ligated, stapled, or occluded with synthetic polymers. In this article we present a patient who has undergone a total pancreatectomy with segmental pancreatic autotransplantation and subsequent Roux-en-Y anastomosis to the transplanted duct. Physiologic studies indicate normal endocrine function 7 years following transplant. The patient is insulin-independent and tolerates a normal meal, requiring no oral pancreatic enzyme supplementation. To our knowledge this is the first long-term report of a patient with an autotransplanted pancreas who is presently both insulin sufficient and with intact exocrine function.
Soon-Shiong
P
P
Swafford
G
G
Levin
S
S
D001786:Blood Glucose / Q000378:metabolism; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008875:Middle Aged; D010179:Pancreas / Q000502:physiology; D016035:Pancreas Transplantation; D010180:Pancreatectomy; D010183:Pancreatic Ducts / Q000378:metabolism / Q000601:surgery; D010195:Pancreatitis / Q000503:physiopathology / Q000601:surgery; D014182:Transplantation, Autologous
D001786:Blood Glucose; D007328:Insulin