title: Structure and function of E. coli promoter DNA.
abstract: The process of transcription initiation requires both the recognition of a promoter site by RNA polymerase and the melting of a short stretch of DNA. In this review I discuss the properties of promoters that are relevant to sequence recognition and to the ability of the polymerase to act as a melting protein. The regulation of promoter activity is thus dependent on both factors interacting with RNA polymerase and so altering its affinity for promoter sites and also modulations of DNA structure.
authors.affiliation: Laboratory of Molecular Biology, Medical Research Council, Cambridge, England.
authors.forename: A A
authors.initials: AA
authors.lastname: Travers
mesh_terms: D001483:Base Sequence; D004269:DNA, Bacterial / Q000502:physiology*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics*; D008957:Models, Genetic; D009690:Nucleic Acid Conformation; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
chemical_list: D004269:DNA, Bacterial; D012321:DNA-Directed RNA Polymerases