[Experimental evaluation of the biliary tract passage of ceftriaxone and its hepatic disposition].
The biliary elimination of ceftriaxone was studied by an isolated perfused rabbit liver model (n = 5). After adding of 10 mg of this antibiotic to the circulating blood of this preparation, a mean biliary peak level reaching 120.5 +/- 24.6 micrograms/ml was obtained between the 30th and 60th minutes. The total amount of ceftriaxone eliminated unchanged in the bile collected during a 3h period represents 8.8 +/- 2.6% of the administered dose. At the end of this study period, 32.7 +/- 3.3% of the initial dose remained in the circulating blood. The hepatic tissue concentrated 3.7% of the whole dose. At last, control experiments proved that 36.4% of the added antibiotic has been degraded by the experimental system itself. Thus the remaining 18.4% can be attributed to a hepatic biotransformation of ceftriaxone.
Brogard
J M
JM
Blickle
J F
JF
Jehl
F
F
Dorner
M
M
Monteil
H
H
D000818:Animals; D001646:Bile / Q000378:metabolism*; D002443:Ceftriaxone / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D010477:Perfusion; D011817:Rabbits
D002443:Ceftriaxone
Evaluation expérimentale du passage biliaire de la ceftriaxone et de sa disposition hépatique.