Reduction in cardiovascular risk factors with intensive diabetes treatment in insulin-dependent diabetes mellitus.
We measured plasma lipid and lipoprotein levels at baseline and at 6-mo intervals in 47 normolipidemic patients with classic insulin-dependent diabetes mellitus treated either with a conventional (n = 21) or intensive (n = 26) diabetes-treatment program. Patients were followed for a mean of 3 yr (range 1-4 yr). Intensive diabetes treatment resulted in a significant improvement in glycemic control that caused sustained changes in plasma lipid and lipoprotein levels that were not evident with the conventional-treatment program. These changes, which persisted for periods averaging 3 yr, can potentially reduce predicted risk for the development of premature atherosclerosis. Thus, long-term near normoglycemia may have a role in the prevention of atherosclerosis in insulin-dependent diabetic patients.
Rosenstock
J
J
University of Texas Health Science Center, Dallas 75235.
Strowig
S
S
Cercone
S
S
Raskin
P
P
D000328:Adult; D001161:Arteriosclerosis / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D003925:Diabetic Angiopathies / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D007332:Insulin Infusion Systems; D008074:Lipoproteins / Q000097:blood; D008297:Male; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D007328:Insulin; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol