title: [Reaction of the hematopoietic system in mice to the administration of virulent and avirulent strains of Shigella flexneri 2A].
abstract: The influence of live bacteria and antigenic preparations of virulent and avirulent stains of Shigella flexneri 2a on the endogenous splenic colony formation in murine hematopoietic cells has been studied. The different stimulating activity of live microbial cells of virulent and avirulent strains Shigella flexneri 2a and their antigenic preparations on the endogenous colony formation has been shown. The effect observed depends on the preparation doses and time of their administration before irradiation of the animals. The stimulating influence on the development of hemopoiesis endogenous foci may be conditioned by the action of heat-labile products of the live microbial cells and closely correlates with the virulence of strains studied.
authors.forename: T N
authors.initials: TN
authors.lastname: Nikolaeva
authors.forename: A V
authors.initials: AV
authors.lastname: Sanin
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Belaia
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000633:toxicity; D003114:Colony-Forming Units Assay; D004306:Dose-Response Relationship, Immunologic; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000528:radiation effects; D006413:Hematopoietic System / Q000276:immunology / Q000382:microbiology* / Q000528:radiation effects; D051379:Mice; D008808:Mice, Inbred CBA; D012763:Shigella flexneri / Q000276:immunology / Q000472:pathogenicity*; D013154:Spleen / Q000276:immunology / Q000528:radiation effects; D013997:Time Factors; D014774:Virulence
chemical_list: D000942:Antigens, Bacterial
vernacular_title: Reaktsiia krovetvornoĭ sistemy mysheĭ na vvedenie virulentnogo i avirulentnogo shtammov shigell Fleksnera 2A.