Human erythrocyte glutathione S-transferase: a possible marker of chemical exposure.
We have explored the possibility of using glutathione S-transferase (GST) as a biological marker of chemical exposure. All the model compounds tested in the present study (acrolein, propylene oxide, styrene oxide, ethylene dibromide and ethylene dichloride) showed a dose-dependent inactivation of erythrocyte GST in situ as well as the inhibition of purified erythrocyte GST.
Ansari
G A
GA
Singh
S V
SV
Gan
J C
JC
Awasthi
Y C
YC
D000171:Acrolein / Q000494:pharmacology; D004781:Environmental Exposure; D004852:Epoxy Compounds / Q000494:pharmacology; D004912:Erythrocytes / Q000201:enzymology*; D015946:Ethylene Dibromide / Q000494:pharmacology; D005025:Ethylene Dichlorides / Q000494:pharmacology; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors / Q000097:blood*; D006801:Humans
D004852:Epoxy Compounds; D005025:Ethylene Dichlorides; D015946:Ethylene Dibromide; C024565:ethylene dichloride; D000171:Acrolein; C013690:styrene oxide; D005982:Glutathione Transferase; C009068:propylene oxide