title: Tissue specificity in nerve regeneration.
abstract: In 1944 Weiss & Taylor presented experimental evidence against "neurotropism" in nerve regeneration. We used a silicone Y-chamber system to repeat some of those experiments. The proximal stump of transected rat sciatic nerve was introduced into the proximal inlet of the Y. One of the distal outlets was left empty, plugged or occupied by a tendon graft, the other outlet being occupied by a nerve graft. Analysis after 4 and 12 weeks showed in all cases a preferential or exclusive axonal growth towards the nerve piece. The results, indicating the existence of "tissue specificity", are contradictory to the results reported by Weiss & Taylor (30). The findings are discussed with respect to possible influence of humoral, cellular and molecular factors associated with the distal nerve stump as well as the matrix, formed between both nerve segments.
authors.forename: G
authors.initials: G
authors.lastname: Lundborg
authors.forename: L B
authors.initials: LB
authors.lastname: Dahlin
authors.forename: N
authors.initials: N
authors.lastname: Danielsen
authors.forename: A K
authors.initials: AK
authors.lastname: Nachemson
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D003584:Cytological Techniques; D009416:Nerve Regeneration; D009928:Organ Specificity; D051381:Rats; D012584:Sciatic Nerve / Q000502:physiology* / Q000637:transplantation / Q000648:ultrastructure; D013710:Tendons / Q000637:transplantation / Q000648:ultrastructure