title: The natriuretic response to hydromineral imbalance.
abstract: Many recent investigations of the mechanism of volume-expansion natriuresis fail to appreciate that the observed renal sodium excretion may not be dependent on an increase in intravascular volume, but rather on the infused sodium load or extracellular fluid volume expansion. With this in mind, the natriuresis of isotonic volume expansion, hypertonic saline infusion, and dehydration have a common basis: they present a relative or absolute sodium load. Lesions of forebrain periventricular tissue prevent the natriuretic response to these three states of body fluid imbalance. In this review we discuss the evidence for a common central nervous system-mediated natriuretic mechanism in response to disturbances of fluid and electrolyte balance. We also propose a role for pars intermedia-derived, proopiomelanocortin-derived peptides as humoral mediators of renal sodium excretion. Evidence from our laboratory, as well as others, provides data for a testable hypothesis to explain central nervous system-mediated natriuresis, as well as an explanation of how central nervous system lesions or neurochemical perturbations affect the renal response to body fluid imbalance.
authors.affiliation: Department of Medicine, Wake Forest University Medical Center, Winston-Salem, North Carolina 27103.
authors.forename: K A
authors.initials: KA
authors.lastname: Gruber
mesh_terms: D000818:Animals; D001810:Blood Volume; D003681:Dehydration / Q000378:metabolism; D004027:Diencephalon / Q000503:physiopathology; D004231:Diuresis; D005110:Extracellular Space / Q000378:metabolism; D007552:Isotonic Solutions; D009318:Natriuresis; D045283:Natriuretic Agents / Q000502:physiology; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D011333:Pro-Opiomelanocortin / Q000502:physiology; D051381:Rats; D012462:Saline Solution, Hypertonic; D014883:Water-Electrolyte Imbalance / Q000503:physiopathology*
chemical_list: D007552:Isotonic Solutions; D045283:Natriuretic Agents; D012462:Saline Solution, Hypertonic; D011333:Pro-Opiomelanocortin