Transient appearance of calcitonin gene-related peptide-like immunoreactive fibers in the developing cerebellum of the rat.
A plexus of calcitonin gene-related peptide (CGRP)-containing fibers were transiently found in the developing cerebellum of the rat by means of the indirect immunofluorescent method. CGRP-like immunoreactive fibers appeared in the cerebellum by embryonic day 22. Immunoreactive fibers rapidly increased and these made a dense plexus in the Purkinje cell layer by postnatal day 2. However, only a few if any immunoreactive fibers were seen in the Purkinje cell layer or molecular layer of adult rats.
Kubota
Y
Y
Inagaki
S
S
Shimada
S
S
Kito
S
S
Zaidi
M
M
Girgis
S I
SI
MacIntyre
I
I
Tohyama
M
M
D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D002531:Cerebellum / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D005455:Fluorescent Antibody Technique; D008297:Male; D009412:Nerve Fibers / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism*; D011689:Purkinje Cells / Q000378:metabolism; D051381:Rats
D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide