title: Immune-mediated glomerulonephritis after exposure to paraquat.
abstract: Exposure to paraquat was followed 1 week later by mild respiratory distress in a previously healthy farmer who developed a mixed nephrotic/nephritic syndrome 3 months later. Percutaneous renal biopsy showed endo-extra-capillary proliferative glomerulonephritis associated with a linear pattern of IgG deposits along the glomerular capillary wall. This is the first case report of an association between exposure to a low dose of paraquat (as suggested by the mildness of the respiratory symptoms) and development of glomerulonephritis, possibly related to the occurrence of anti-glomerular basement membrane antibodies. The possibility is suggested that immune-mediated mechanisms of glomerular damage may be triggered by exposure to low-dose paraquat.
authors.affiliation: Cattedra di Nefrologia, Università di Torino, Italia.
authors.forename: P
authors.initials: P
authors.lastname: Stratta
authors.forename: G
authors.initials: G
authors.lastname: Mazzucco
authors.forename: S
authors.initials: S
authors.lastname: Griva
authors.forename: C
authors.initials: C
authors.lastname: Tetta
authors.forename: G
authors.initials: G
authors.lastname: Monga
mesh_terms: D000293:Adolescent; D001485:Basement Membrane / Q000276:immunology / Q000648:ultrastructure; D003176:Complement C3 / Q000032:analysis; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology / Q000648:ultrastructure; D010269:Paraquat / Q000009:adverse effects*
chemical_list: D003176:Complement C3; D007074:Immunoglobulin G; D010269:Paraquat