title: Mediators of altered perioperative physiology.
abstract: Several recent papers have described the development of a new study discipline, psychoneuroimmunology. "The new science begins with the premise that neither the brain nor the immune system can be excluded from any scheme that proposes to account for the onset and course of human disease." This article addresses the concept as it pertains to the perioperative state. Two basic ideas are necessary framework for this discussion, the notion of reflex arcs and a definition of stress.
authors.affiliation: University of California, Irvine Medical Center, Orange.
authors.forename: K
authors.initials: K
authors.lastname: O'Neal
authors.forename: K
authors.initials: K
authors.lastname: Waxman
mesh_terms: D000311:Adrenal Glands / Q000502:physiology; D004723:Endorphins / Q000502:physiology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007432:Intraoperative Period; D011184:Postoperative Period; D011453:Prostaglandins / Q000502:physiology; D011598:Psychoneuroimmunology; D013312:Stress, Physiological / Q000503:physiopathology*; D013514:Surgical Procedures, Operative
chemical_list: D004723:Endorphins; D011453:Prostaglandins