Morphologic changes induced by short-term ischemia in the rat testis are not affected by treatment with superoxide dismutase and catalase.
Short-term testicular ischemia was induced unilaterally by ligating the testicular artery for 60 or 100 minutes in adult rats. After 7 days, the rats were fixed by vascular perfusion. The effect of ischemia and reperfusion was quantified using morphometric techniques. Occlusion of the testicular artery for 60 and 100 minutes resulted in a mild and moderate damage, respectively, to the seminiferous tubules. The contralateral control testis was not affected. To study the role of oxygen radicals in ischemia-reperfusion-induced testicular damage, rats were treated with superoxide dismutase and catalase. These radical scavengers did not influence the extent of testicular damage.
Bergh
A
A
Department of Pathology, University of Umeå, Sweden.
Damber
J E
JE
Marklund
S L
SL
D000818:Animals; D001158:Arteries; D002374:Catalase / Q000493:pharmacokinetics / Q000494:pharmacology*; D007511:Ischemia / Q000473:pathology*; D007985:Leydig Cells / Q000473:pathology; D008026:Ligation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012671:Seminiferous Tubules / Q000473:pathology; D013094:Spermatozoa / Q000473:pathology; D013482:Superoxide Dismutase / Q000493:pharmacokinetics / Q000494:pharmacology*; D013737:Testis / Q000098:blood supply* / Q000187:drug effects / Q000473:pathology
D002374:Catalase; D013482:Superoxide Dismutase