title: Unbalanced translocation (1;7) in childhood myelodysplasia.
abstract: We have identified an unusual pediatric patient among twelve patients with myelodysplasia and an unbalanced translocation involving chromosomes 1 and 7: -7, +der(1)t(1;7)(p11;p11). This 16-year-old male patient developed myelodysplasia and evolving acute leukemia, which were preceded by a 7-year history of marrow hypoplasia. The remaining patients were adults with clinical and hematologic findings similar to other reported cases with this chromosomal abnormality. The late appearance of this unbalanced clonal abnormality in this patient with marrow hypoplasia documents the importance of close cytogenetic follow-up of all patients with suspected bone marrow injury.
authors.affiliation: Department of Pathology, British Columbia Children's Hospital, Canada.
authors.forename: D E
authors.initials: DE
authors.lastname: Horsman
authors.forename: B G
authors.initials: BG
authors.lastname: Massing
authors.forename: K W
authors.initials: KW
authors.lastname: Chan
authors.forename: D K
authors.initials: DK
authors.lastname: Kalousek
mesh_terms: D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D003582:Cytogenetics; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic
chemical_list: D006454:Hemoglobins