title: Involvement of hippocampus in Creutzfeldt-Jakob disease.
abstract: The hippocampus is generally believed to be only rarely affected in Creutzfeldt-Jakob disease. In a systematic study of the hippocampus in 6 cases of Creutzfeldt-Jakob disease, the stratum moleculare-lacunosum showed a definite spongiform change with gliosis in 5 cases. The stratum radiatum et pyramidale showed spongiform change in 3 of the 5 cases. The subiculum, presubiculum, parasubiculum and entorhinal cortex were involved in all the cases. These results suggest that involvement of the hippocampus may not be uncommon in Creutzfeldt-Jakob disease. The stratum moleculare-lacunosum seems to be the site preferentially affected. This pathology may contribute to progression of dementia in Creutzfeldt-Jakob disease.
authors.affiliation: Department of Pathology, Montefiore Medical Center, Bronx, NY 10467.
authors.forename: H
authors.initials: H
authors.lastname: Mizusawa
authors.forename: A
authors.initials: A
authors.lastname: Hirano
authors.forename: J F
authors.initials: JF
authors.lastname: Llena
mesh_terms: D000328:Adult; D000368:Aged; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged