title: Study of antibody response to 4 streptococcal antigens in rheumatic fever and Kawasaki disease with or without cardiovascular lesions.
abstract: Patients with rheumatic fever (RF) and Kawasaki disease (MCLS) were divided into two groups, one with and the other without cardiovascular lesions, and their sera were examined for antibodies to 4 streptococcal antigens: anti-streptococcal polysaccharide (ASP), anti-deoxyribonuclease B (ADN-B), anti-streptolysin O (ASO) and anti-streptokinase (ASK) in order to clarify the relationship between group A streptococci and these two diseases. In RF the frequency of positive levels of ASP at its early stage was lower than those of the other 3 antibodies, but the ASP titer tended to persist at elevated levels. The frequency of ADN-B in patients with rheumatic heart disease (RHD) was higher than that in those without RHD, but with regard to the other antibodies no difference was found between the two. Of the 4 antibodies the frequency of at least one positive level was 100% in all the sera of RF patients within 3 months from onset. The differences in the frequencies of positive levels of all 4 antibodies in both MCLS and the controls did not prove to be significant. The frequencies of ASP, ADN-B and ASO in the sera of patients without cardiovascular lesions tended to be slightly higher than those in patients with cardiovascular lesions.
authors.affiliation: Department of Nursing, School of Allied Medical Sciences, Kagoshima, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hokonohara
authors.forename: M
authors.initials: M
authors.lastname: Yoshinaga
authors.forename: Y
authors.initials: Y
authors.lastname: Baba
mesh_terms: D000293:Adolescent; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins; D002318:Cardiovascular Diseases / Q000150:complications; D002648:Child; D003851:Deoxyribonucleases / Q000276:immunology; D006801:Humans; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology; D012213:Rheumatic Fever / Q000150:complications / Q000276:immunology*; D013297:Streptococcus pyogenes / Q000276:immunology*; D013300:Streptokinase / Q000276:immunology; D013301:Streptolysins / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D011135:Polysaccharides, Bacterial; D013301:Streptolysins; C036112:streptococcal polysaccharide group A; C025964:streptolysin O; D003851:Deoxyribonucleases; D013300:Streptokinase