Steroid hormones enhanced sister-chromatid exchange in cultured CHO cells.
The influence of steroid hormones on the induction of sister-chromatid exchange (SCE) in cultured CHO cells was studied. It was observed that estradiol-17 beta, estriol, estrone and ethynyl estradiol treatments enhanced SCE rates compared to the controls. Overall, these compounds produced a dose response effect. The importance of a detailed study on the long-term genetic effects of steroids on mammalian cells is emphasized.
Kochhar
T S
TS
Division of Mathematics and Sciences, Kentucky State Univesity, Frankfort 40601.
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D004958:Estradiol / Q000494:pharmacology; D004964:Estriol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D004970:Estrone / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D004967:Estrogens; D004970:Estrone; D004997:Ethinyl Estradiol; D004958:Estradiol; D004964:Estriol