[Radioprotective action of a GGS-10 gaseous hypoxic mixture on the DNA supramolecular complex of normal tissues and sarcoma 45 of rats].
Gas hypoxic mixture (GHM-10) inhaled by rats during gamma-irradiation (2 to 20 Gy) effectively protects the supramolecular complex of DNA (SC DNA) in bone marrow and spleen, but fails to protect this complex in sarcoma 45. GHM-10 itself has been shown to induce rapid and prolonged, but irreversible, decrease in SC DNA elastic viscosity in normal tissues.
Strazhevskaia
N B
NB
Struchkov
V A
VA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000528:radiation effects*; D003131:Combined Modality Therapy; D004247:DNA / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D009584:Nitrogen / Q000494:pharmacology* / Q000627:therapeutic use; D010100:Oxygen / Q000494:pharmacology* / Q000627:therapeutic use; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000532:radiotherapy*; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects*
D011837:Radiation-Protective Agents; C041364:nitrox; D004247:DNA; D009584:Nitrogen; D010100:Oxygen
Radiozashchitnoe deĭstvie gazovoĭ gipoksicheskoĭ smesi GGS-10 na nadmolekuliarnyĭ kompleks DNK mormal'nykh tkaneĭ i sarkomy 45 krys.