Inability of [125I]Sar1, Ile8-angiotensin II to move between the blood and cerebrospinal fluid compartments.
The angiotensin II competitive antagonist [125I]-Sar1, Ile8-angiotensin II was not transported from the vascular space to the cerebroventricular space in either intact or nephrectomized rats. In addition [125I]Sar1, Ile8-angiotensin II lacked the capacity to move in the opposite direction over a 20-min collection period following cerebroventricular infusion. These data suggest that angiotensins lack the capacity to move freely between the blood and cerebrospinal fluid compartments and are consistent with the notion that blood-borne and cerebroventricular angiotensins access different receptor populations.
Harding
J W
JW
Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman 99164-6520.
Sullivan
M J
MJ
Hanesworth
J M
JM
Cushing
L L
LL
Wright
J W
JW
D015059:1-Sarcosine-8-Isoleucine Angiotensin II / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D000804:Angiotensin II / Q000031:analogs & derivatives*; D000818:Animals; D001692:Biological Transport; D001812:Blood-Brain Barrier; D002552:Cerebral Ventricles / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D007457:Iodine Radioisotopes; D008297:Male; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains
D007457:Iodine Radioisotopes; D000804:Angiotensin II; D015059:1-Sarcosine-8-Isoleucine Angiotensin II