title: An attempt to assess the replacement dose of human growth hormone in the treatment of growth hormone deficient children.
abstract: In 25 patients with hGH deficiency, who had been treated long-term with hGH, the mode of hGH administration was switched from the conventional method (0.3-0.5 IU/kg/week, in two or three divided doses, intramuscularly) to daily subcutaneous injection at 1900-2100 hours with a dose of 0.46 +/- 0.07 IU/kg/week (equivalent to 14.7 +/- 2.0 IU/m2/week). After 1-3 months of this new mode of hGH administration, blood and urine were sampled at 0900 hours after overnight fasting. Blood glucose, plasma insulin, plasma IGF-1 and plasma total IGF (after extraction) were analysed in blood samples. IGF-1 and hGH were measured in urine samples. These measurements indicated that the dose studied was close to a replacement one, but might be slightly higher than the exact replacement dose.
authors.affiliation: National Children's Medical Research Centre, Tokyo, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Hibi
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Yano
authors.forename: S
authors.initials: S
authors.lastname: Umezawa
authors.forename: J
authors.initials: J
authors.lastname: Kagawa
authors.forename: A
authors.initials: A
authors.lastname: Tanae
authors.forename: E
authors.initials: E
authors.lastname: Ishikawa
mesh_terms: D000293:Adolescent; D002648:Child; D004334:Drug Administration Schedule; D006130:Growth Disorders / Q000188:drug therapy*; D013006:Growth Hormone / Q000008:administration & dosage / Q000172:deficiency / Q000627:therapeutic use*; D006801:Humans; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000097:blood; D013997:Time Factors
chemical_list: D007328:Insulin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone