Characterization of a newly established human urinary bladder cancer cell line (BT-1).
A new human transitonal cell carcinoma cell line has been established in long term tissue culture. The BT-1 cells were derived from a poorly differentiated human bladder cancer. The tumor cell line produces tumors in nude mice. BT-1 has been characterized by cytogenetic and flow cytometric analysis and by isoenzyme typing. As in direct preparations of human bladder tumors, an isochromosome 5p is a consistent marker of the newly established line. The BT-1 cells produce transforming growth factors but do not respond to exogeneous EGF.
Heckl
W
W
Department of Urology, University of Würzburg, School of Medicine, Federal Republic of Germany.
Köhler
J
J
Hoehn
H
H
Dämmrich
J
J
D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000473:pathology*; D002460:Cell Line; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007621:Karyotyping; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000473:pathology*
D066246:ErbB Receptors