Anti-inflammatory activity of superoxide dismutases: inhibition of carrageenan induced edema in rats.
Eighteen different superoxide dismutases from procaryote, plant, fish, bird and mammalian species have been tested for anti-inflammatory activity in the rat paw pad carrageenan-induced inflammation model. Very large differences in activity are observed. Homologous rat Cu-SOD is not active and indeed shows slight pro-inflammatory activity. The different SODs have different iso-electric values, different metals (Cu, Mn or Fe) at the active centre, different molecular weights and different circulation lifetimes. Biological activity is a function of amino acid sequence rather than of such secondary parameters.
Jadot
G
G
Service de Pharmacologie, Faculté de Pharmacie, Marseille, France.
Michelson
A M
AM
Puget
K
K
D000818:Animals; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D004926:Escherichia coli / Q000201:enzymology; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*
D002351:Carrageenan; D013482:Superoxide Dismutase