Excretion of N-mononitrosopiperazine in urine in workers manufacturing piperazine.
Piperazine has been shown to nitrosate in vivo to N-mononitrosopiperazine (MNPZ) by oral intake. Urine from workers exposed to piperazine in a chemical plant was analysed for nitrosamines by gas chromatography-thermal energy analysis. In five out of 11 exposed cases, MNPZ excretion in urine was 0.3 to 4.7 micrograms/24 h (during and after a work shift). In four cases, MNPZ was detected in some urine samples, and in two cases MNPZ was not detected (less than 0.1 ng/ml). The individual excretion was strongly dependent on piperazine exposure, which ranged from 0.06 to 1.7 mg/m3 (time-weighted average; Spearman's rank correlation 0.78, P = 0.01). The MNPZ excretion showed no significant correlation with nitrite or nitrate in saliva (both: r = 0.50, P = 0.10).
Bellander
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T
Institute of Environmental Health, University of Lund, Sweden.
Osterdahl
B G
BG
Hagmar
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L
Skerfving
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S
D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis*; D002617:Chemical Industry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000378:metabolism / Q000652:urine; D009602:Nitrosamines / Q000652:urine*; D000077489:Piperazine; D010879:Piperazines / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism; D012977:Sodium Nitrite / Q000378:metabolism
D000395:Air Pollutants, Occupational; D009566:Nitrates; D009602:Nitrosamines; D010879:Piperazines; D000077489:Piperazine; C031618:sodium nitrate; D012977:Sodium Nitrite; C014711:1-nitrosopiperazine