Mutagenic action of phaseolinone, a mycotoxin isolated from Macrophomina phaseolina.
Phaseolinone was mutagenic to excision-repair-deficient strains of Escherichia coli WP2 and also to Salmonella typhimurium TA 100. The repair test was indicative of covalent binding of the toxin to DNA. The side-chain epoxide and the hydroxy groups of the molecule were found to be essential for mutagenic activity.
Bhattacharya
G
G
Indian Institute of Chemical Biology, Jadavpur, Calcutta.
Dhar
T K
TK
Bhattacharyya
F K
FK
Siddiqui
K A
KA
D055598:Chemical Phenomena; D002621:Chemistry; D004926:Escherichia coli / Q000187:drug effects; D003904:Mitosporic Fungi / Q000032:analysis*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000302:isolation & purification*; D009183:Mycotoxins / Q000302:isolation & purification / Q000494:pharmacology*; D009284:Naphthols / Q000302:isolation & purification / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship
D009153:Mutagens; D009183:Mycotoxins; D009284:Naphthols; C056401:phaseolinone