Magnesium therapy for acute myocardial infarction.
Acute myocardial infarction carries a high risk of potentially fatal ventricular arrhythmias during the first 24 hours after the infarct. At this time there is an efflux of K and Mg ions from the injured cells with an associated rise in these cations in the lymphocytes of the peripheral blood. There is a close association between these arrhythmias and the levels of these cations, with a high K level associated with an increased incidence of arrhythmias and a high Mg level being associated with a protective effect. Treatment with a continuous infusion of Mg is highly effective in the prevention of these arrhythmias resulting in a fall in inhospital mortality.
Abraham
A S
AS
Department of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
D000200:Action Potentials; D006321:Heart / Q000502:physiology; D006801:Humans; D008214:Lymphocytes / Q000032:analysis; D008274:Magnesium / Q000378:metabolism / Q000502:physiology; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D009206:Myocardium / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism / Q000502:physiology
D008278:Magnesium Sulfate; D008274:Magnesium; D011188:Potassium