Failure of diterpenes from Jatropha curcas to induce mutation in Salmonella typhimurium TA98 and TA100.
No mutagenicity of five diterpenes isolated from the roots of Jatropha curcas was detected by Ame's test using both TA98 and TA100 tester strains with or without S-9 fraction from livers of rats treated with polychlorinated biphenyl.
Rojanapo
W
W
Research Division, National Cancer Institute, Bangkok, Thailand.
Pimbua
J
J
Glinsukon
T
T
Naengchomnong
W
W
Thebtaranonth
Y
Y
D000818:Animals; D001711:Biotransformation; D004224:Diterpenes / Q000493:pharmacokinetics / Q000633:toxicity*; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000493:pharmacokinetics; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics
D004224:Diterpenes; D009153:Mutagens