Hematologic and serum biochemical alterations associated with multiple halothane anesthesia exposures and minor surgical trauma in horses.
Five horses were anesthetized similarly by use of xylazine, guaifenesin, thiamylal sodium, and halothane in oxygen on 3 consecutive days, and minor surgical procedures were performed. For 1 to 10 days after the last anesthetic exposure, clinical, hematologic, and serum biochemical features were monitored, and after necropsy, histologic examination of major organ tissues was performed. Predominant hematologic changes from base-line values included leukocytosis (maximal at 27 hours, 10,500 +/- 1,750 cells/microliter), neutrophilia (maximal at 51 hours, 7,485 +/- 1,719 cells/microliter), and lymphopenia (minimal at 51 hours, 1,636 +/- 564 cells/microliter). Alterations observed in other clinicopathologic features were minor and indicative of mild renal disturbance and nonspecific cellular necrosis. Histopathologic lesions in the liver were mild.
Stover
S M
SM
Department of Anatomy, School of Veterinary Medicine, University of California, Davis 95616.
Steffey
E P
EP
Dybdal
N O
NO
Franti
C E
CE
D000768:Anesthesia, General / Q000662:veterinary*; D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D005260:Female; D006221:Halothane; D006734:Horse Diseases / Q000097:blood* / Q000473:pathology; D006736:Horses / Q000097:blood / Q000601:surgery*; D007958:Leukocyte Count / Q000662:veterinary; D007964:Leukocytosis / Q000662:veterinary; D008099:Liver / Q000473:pathology; D008231:Lymphopenia / Q000662:veterinary; D008297:Male; D009504:Neutrophils; D011183:Postoperative Complications / Q000097:blood / Q000473:pathology / Q000662:veterinary*
D006221:Halothane