title: Fetal liver transplantation in aplastic anemia and leukemia.
abstract: This study reviews results of fetal liver transplantation in hematologic disorders including aplastic anemia, leukemia and thalassemia. One hundred and twenty two patients received transplants for aplastic anemia; engraftment was reported in 4 patients; graft-versus-host disease (GvHD) did not occur. Complete and partial responses were reported in one-half of patients, the majority of whom had no evidence of engraftment. Thirty-nine patients received transplants for leukemia. Transient engraftment was reported in 40% and two developed GvHD; survival extended to more than 2 years. The higher rate of engraftment in patients with leukemia suggests a role of pretransplant immune suppression. The risk of GvHD appears to be low despite complete HLA-mismatching. These data suggest a possible role for fetal liver transplantation in man. Future studies should probably be based on preclinical data obtained in large animal models.
authors.affiliation: Department of Medicine, UCLA School of Medicine 90024.
authors.forename: R P
authors.initials: RP
authors.lastname: Gale
mesh_terms: D000741:Anemia, Aplastic / Q000628:therapy*; D005333:Fetus; D006680:HLA Antigens / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D008099:Liver / Q000196:embryology; D016031:Liver Transplantation
chemical_list: D006680:HLA Antigens