[Effect of aminazine and triftazin on the synaptosome membranes of the rat cerebral cortex].
Fluorescent probes 1,6-diphenyl-1,3,5-hexatriene (DPH) and pyrene were employed in studying the effect of aminazine and triftazin versus that of imipramine on microviscosity of rat brain cortex synaptosomal membranes. Unlike imipramine, the neuroleptics decrease microviscosity of membrane's lipid bilayer. All drugs decrease fluorescence of endogenous tryptophan, but fail to change fluorescence of L-tryptophan in the solution. It is concluded that neuroleptics induce conformational perturbations in membrane-bound proteins modifying microviscosity of lipid bilayer whereas imipramine changes the surface electric charge of lipid bilayer of synaptosomal membranes.
Avdulov
N A
NA
Eremenko
A V
AV
Val'dman
A V
AV
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D005456:Fluorescent Dyes; D007099:Imipramine / Q000494:pharmacology; D007425:Intracellular Membranes / Q000187:drug effects*; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects*; D014268:Trifluoperazine / Q000494:pharmacology*; D014783:Viscosity
D005456:Fluorescent Dyes; D014268:Trifluoperazine; D007099:Imipramine; D002746:Chlorpromazine
Vliianie aminazina i triftazina na sinaptosomnye membrany kory golovnogo mozga krys.