Inhibition by tetanus and botulinum A toxin of the release of [3H]noradrenaline and [3H]GABA from rat brain homogenate.
Rat brain homogenate was preloaded with [3H]noradrenaline or [3H]GABA and stimulated with high K+. Tetanus toxin and botulinum A neurotoxin partially prevent the evoked [3H]noradrenaline release in the same range of toxin concentrations starting below 10(-10) M. In contrast, release of gamma-amino butyric acid (GABA) is much more sensitive to tetanus than to botulinum A toxin.
Habermann
E
E
Buchheim-Institut für Pharmakologie der Justus-Liebig-Universität, Giessen, Federal Republic of Germany.
D000818:Animals; D001905:Botulinum Toxins / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D066298:In Vitro Techniques; D009638:Norepinephrine / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D013744:Tetanus Toxin / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D013744:Tetanus Toxin; D005680:gamma-Aminobutyric Acid; D001905:Botulinum Toxins; D011188:Potassium; D009638:Norepinephrine