Allogeneic bone marrow transplantation using partially-matched related donors.
Six patients with advanced leukemia and one with severe combined immunodeficiency syndrome received allogeneic bone marrow transplantation (BMT) from HLA haploidentical donors who were compatible for one or two loci on the non-shared chromosome. Methotrexate was used for prophylaxis against acute graft-versus-host disease (GVHD). All patients engrafted but developed moderate to severe acute GVHD, and three patients died. Two leukemic patients relapsed but two others survived and were free of disease 403 and 936 days post-transplant. BMT using related partially matched donors may result in durable engraftment and long-term survivors. The implications of using such donors in expanding the application of BMT are discussed.
Chan
K W
KW
Leukemia and Bone Marrow Transplantation Program of British Columbia, Vancouver General Hospital, Vancouver, Canada.
Fryer
C J
CJ
Denegri
J F
JF
Buskard
N A
NA
Phillips
G L
GL
D016026:Bone Marrow Transplantation; D006086:Graft vs Host Disease / Q000150:complications / Q000628:therapy; D006680:HLA Antigens / Q000276:immunology; D006648:Histocompatibility; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000628:therapy*; D007938:Leukemia / Q000628:therapy*; D014019:Tissue Donors; D014777:Virus Diseases / Q000150:complications
D006680:HLA Antigens