Adverse reactions and immunogenicity in adults to regular and increased dosage of diphtheria vaccine.
Booster doses of 3 Lf or 7.5 Lf of a regular diphtheria vaccine were given to 200 previously immunized adult volunteers. The toxoid was prepared from toxin with a purity of 2100 Lf/mg protein nitrogen and adsorbed to aluminium phosphate. Systemic reactions were rare and no severe symptoms were observed. Local reactions occurred in 40-50% of the vaccinees, but in only 7.5% were they of clinical significance, i.e. an area of redness/swelling greater than 5 cm. The two doses did not cause significant differences in reaction rates, and the 7.5 Lf dose elicited a better antitoxin response. Thus, a dose of 7.5 Lf diphtheria toxoid of similar purity can safely be given to adults in vaccines.
Björkholm
B
B
Department of Infectious Diseases, Ostra sjukhuset, Göteborg, Sweden.
Granström
M
M
Wahl
M
M
Hedström
C E
CE
Hagberg
L
L
D000328:Adult; D002986:Clinical Trials as Topic; D004166:Diphtheria Antitoxin / Q000032:analysis*; D004168:Diphtheria Toxoid / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D007117:Immunization, Secondary / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
D004166:Diphtheria Antitoxin; D004168:Diphtheria Toxoid