title: A double-blind clinical trial of prophylactic cloxacillin in open fractures.
abstract: In 100 patients with first-, second-, and third-degree open fractures, a randomized, double-blind study was carried out to compare prophylactic cloxacillin and placebo. Prophylaxis was started preoperatively and continued for 10 days. The standard fracture treatment consisted of operative stabilization, mostly by means of plates or external fixators. In the cloxacillin group two infections were observed as compared to 12 in the control group. This difference was significant.
authors.affiliation: Clinic of Eich, Foundation Norbert Metz, Luxembourg.
authors.forename: R
authors.initials: R
authors.lastname: Braun
authors.forename: M A
authors.initials: MA
authors.lastname: Enzler
authors.forename: W W
authors.initials: WW
authors.lastname: Rittmann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000517:prevention & control; D002986:Clinical Trials as Topic; D003023:Cloxacillin / Q000627:therapeutic use*; D004311:Double-Blind Method; D005121:Extremities / Q000293:injuries*; D005260:Female; D005593:Fracture Fixation, Internal; D005597:Fractures, Open / Q000382:microbiology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011292:Premedication; D011897:Random Allocation; D013203:Staphylococcal Infections; D013211:Staphylococcus aureus / Q000302:isolation & purification
chemical_list: D010919:Placebos; D003023:Cloxacillin