[Morphological changes in pulmonary alveolus macrophages as affected by alcohol and nitrosodimethylamine].
Comparative electron microscopic studies of lung alveolar macrophage (LAM) ultrastructure (with their surface architectonics) were performed in transmission and scan regimen in 3 groups of animals: in intact rats and in rats 12 and 24 hours after a single intragastric administration of nitrosodimethylamine at a concentration of 30 mg/kg in one case and of 50% ethanol (2 ml per 100 g animal weight) in the other case. The transformation of cytoplasmic excrescences, manifested in their diminution, twisting and fusion resulted in the formation of fold-hilly LAM surface. The data obtained may be used for the elaboration of criteria for the assessment of environmental effects of toxic factors.
Fetisov
V V
VV
Gasimova
Z M
ZM
Litvinov
L N
LN
Baldaeva
L L
LL
D000818:Animals; D004128:Dimethylnitrosamine / Q000633:toxicity*; D000431:Ethanol / Q000633:toxicity*; D008264:Macrophages / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D011650:Pulmonary Alveoli / Q000166:cytology* / Q000187:drug effects; D051381:Rats
D000431:Ethanol; D004128:Dimethylnitrosamine
Morfologicheskoe izmenenie al'veoliarnykh makrofagov legkikh pri deĭstvii alkogolia i nitrozodimetilamina.