Expression of c-myc is under dietary control in rat liver.
Expression of c-myc has often been related to the control of growth and differentiation of a variety of cell types. However, in some cases, such a relation has not been found. The rate of cell division is very low in liver, but c-myc expression is yet easily detected. We show here that a short-time physiological fasting results in a dramatic decrease of c-myc expression in rat liver. This effect does not seem to be dependent on glucagon, since administration of glucagon leads to an increase in c-myc mRNA. This is to our knowledge, the first evidence of a physiological variation of proto-oncogene expression linked to food intake, and we suggest that this variation could play a role in liver cell growth control.
Corcos
D
D
Unité Associée CNRS UA 1147, Paris, France.
Vaulont
S
S
Denis
N
N
Lyonnet
S
S
Simon
M P
MP
Kitzis
A
A
Kahn
A
A
Kruh
J
J
D000818:Animals; D004032:Diet; D005215:Fasting; D005786:Gene Expression Regulation; D005796:Genes; D011905:Genes, ras; D005934:Glucagon / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D011519:Proto-Oncogenes; D011770:Pyruvate Kinase / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains
D012333:RNA, Messenger; D005934:Glucagon; D011770:Pyruvate Kinase