Melanocytic atypia in dysplastic nevi. Immunohistochemical and cytophotometrical analysis.
In a double-blind study a correlation was found between the histologically assessed degree of nevomelanocytic atypia in 58 dysplastic nevi (DN) and the presence of two markers associated with malignant transformation. The markers included a marked expression of histocompatibility locus Class I antigens on nevomelanocytes (P less than 0.01) and abnormalities in the nuclear DNA content as measured by DNA cytophotometry (P = 0.01). Both markers were present in most of the markedly atypical DN, in about half of the moderately atypical DN, and in less than 30% of the mildly atypical DN. These findings suggest that a DN with marked or moderate melanocytic atypia indicates a premalignant condition and identifies a patient at risk for melanoma.
Bergman
W
W
Department of Dermatology, University Medical Center, Leiden, The Netherlands.
Ruiter
D J
DJ
Scheffer
E
E
van Vloten
W A
WA
D000951:Antigens, Neoplasm / Q000032:analysis*; D004273:DNA, Neoplasm / Q000032:analysis*; D004311:Double-Blind Method; D004416:Dysplastic Nevus Syndrome / Q000276:immunology / Q000473:pathology*; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D006965:Hyperplasia; D008544:Melanocytes / Q000032:analysis / Q000276:immunology / Q000473:pathology*; D012878:Skin Neoplasms / Q000032:analysis / Q000276:immunology / Q000473:pathology*
D000951:Antigens, Neoplasm; D004273:DNA, Neoplasm; D006680:HLA Antigens