[Molecular basis for constructing artificial immunogens].
The molecular and cellular mechanisms of the effect of synthetic polyions on immunogenesis are discussed in the paper. The data on the basic properties of polyion immune stimulants and on the mechanisms of cellular reactions to these stimulants were used for constructing artificial antigen-polyion complexes having enhanced immunogenic properties. The vaccinating properties of a number of macromolecular complexes conjugated to bacterial and viral antigens are analyzed.
Khaitov
R M
RM
D000818:Animals; D000941:Antigens / Q000276:immunology*; D005818:Genetic Engineering; D006801:Humans; D014614:Vaccines, Synthetic
D000941:Antigens; D014614:Vaccines, Synthetic
Molekuliarnye osnovy konstruirovaniia iskusstvennykh immunogenov.