Mitochondrial urea cycle enzymes in rats treated with sodium benzoate.
Since sodium benzoate, which is widely used to treat hyperammonemia its effect on mitochondrial urea cycle enzymes was investigated. its effect on mitochondrial urea cycle enzymes was investigated. Sodium benzoate was administered to urease treated hyperammonemic rats and controls. In both groups no interference with the activity of carbamylphosphate synthetase, ornithine carbamyltransferase and N-acetylglutamate synthetase in the liver could be observed at concentrations of benzoate in plasma found in hyperammonemic patients. Careful monitoring of plasma levels reduces benzoate toxicity as shown in a patient with argininosuccinic aciduria.
Colombo
J P
JP
Department of Clinical Chemistry, Inselspital University of Berne, Switzerland.
Bachmann
C
C
Pfister
U
U
Gradwohl
M
M
D000123:Acetyltransferases / Q000378:metabolism*; D051046:Amino-Acid N-Acetyltransferase; D000641:Ammonia / Q000097:blood; D000818:Animals; D001565:Benzoates / Q000097:blood / Q000494:pharmacology*; D019817:Benzoic Acid; D002222:Carbamoyl-Phosphate Synthase (Ammonia) / Q000378:metabolism*; D006626:Hippurates / Q000097:blood; D007700:Kinetics; D008025:Ligases / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D009954:Ornithine Carbamoyltransferase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014508:Urea / Q000378:metabolism*; D014510:Urease / Q000494:pharmacology
D001565:Benzoates; D006626:Hippurates; D000641:Ammonia; D019817:Benzoic Acid; D014508:Urea; D009954:Ornithine Carbamoyltransferase; D000123:Acetyltransferases; D051046:Amino-Acid N-Acetyltransferase; D014510:Urease; D008025:Ligases; D002222:Carbamoyl-Phosphate Synthase (Ammonia); C030514:hippuric acid