title: Neuron-specific enolase in comatose children.
abstract: Sequential examination of neuron-specific enolase in cerebrospinal fluid and serum was performed in 20 comatose children with acute encephalitis, acute encephalopathy, or Reye's syndrome. Neuron-specific enolase activities corresponded to the degree of brain damage. As neuron-specific enolase levels increased to greater than 80 ng/mL, patients had more severe impairment or died. Neuron-specific enolase may be a useful marker for evaluating the degree of neuronal damage and prognosis.
authors.affiliation: Division of Neurology, Children's Medical Center, Saitama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nara
authors.forename: H
authors.initials: H
authors.lastname: Nozaki
authors.forename: Y
authors.initials: Y
authors.lastname: Nakae
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: T
authors.initials: T
authors.lastname: Ohashi
mesh_terms: D000208:Acute Disease; D001927:Brain Diseases / Q000201:enzymology; D002648:Child; D003128:Coma / Q000201:enzymology*; D004660:Encephalitis / Q000201:enzymology; D005260:Female; D006801:Humans; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D011379:Prognosis; D012202:Reye Syndrome / Q000201:enzymology
chemical_list: D010751:Phosphopyruvate Hydratase