Glucosteroid (GS)-dependent immunomodulation of immunoglobulin biosynthesis in vitro. I. GS stimulate spontaneous immunoglobulin synthesis.
Glucosteroids (GS) enhance spontaneous differentiation of human B lymphocytes to Ig containing plasma cells. The use of the reverse plasque-forming cell (PFC) assay made it possible to subdivide normal donors into GS-responder and non-responder inhibitable group. Peripheral blood B cells appear to be especially prone to GS-dependent enhancement of differentiation. While B cells derived from lymphoid organs retain their susceptibility to GS, they are less sensitive inasmuch enhancement of Ig synthesis is concerned.
Korczak-Kowalska
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Department of Experimental Immunosuppression, Medical Academy, Warsaw.
Górski
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D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000502:physiology*; D000921:Antibody-Producing Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D006462:Hemolytic Plaque Technique; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology / Q000502:physiology*; D007136:Immunoglobulins / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000187:drug effects
D000276:Adjuvants, Immunologic; D007136:Immunoglobulins; D006854:Hydrocortisone