title: Reduced excretion of vasodilator prostaglandins in preeclampsia.
abstract: The role of prostaglandin (PG) system in preeclampsia (pre-E) was investigated. Urinary excretion of PGE2,6-keto PGF1 alpha,2,3 dinor 6-keto PGF1 alpha, TxB2 and 2,3-dinor-TxB2 and kallikrein were determined in 10 normotensive pregnant women and 14 with pre-E. 6-keto PGF1 alpha and 2,3-dinor 6-keto PGF1 alpha (the main renal and extrarenal metabolites of vasodilator PGI2) and PGE2 excretion was lower in pre-E. TxB2 metabolites in urine were similar in the two groups of women. Our data are consistent with the hypothesis of an imbalance between vasodilator and vasoconstrictor PGs in pre-E.
authors.affiliation: Clinica Medica dell'Università, Policlinico di Borgo Roma, Verona, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Minuz
authors.forename: G
authors.initials: G
authors.lastname: Covi
authors.forename: M
authors.initials: M
authors.lastname: Corsato
authors.forename: P
authors.initials: P
authors.lastname: Probitzer
authors.forename: L
authors.initials: L
authors.lastname: Spiazzi
authors.forename: F
authors.initials: F
authors.lastname: Paluani
authors.forename: M
authors.initials: M
authors.lastname: Degan
authors.forename: C
authors.initials: C
authors.lastname: Lechi
authors.forename: A
authors.initials: A
authors.lastname: Lechi
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000031:analogs & derivatives / Q000652:urine; D000328:Adult; D015232:Dinoprostone; D011464:Epoprostenol / Q000378:metabolism; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism; D011225:Pre-Eclampsia / Q000378:metabolism / Q000652:urine*; D011247:Pregnancy; D011453:Prostaglandins / Q000652:urine*; D011458:Prostaglandins E / Q000652:urine; D013928:Thromboxane A2 / Q000378:metabolism; D013929:Thromboxane B2 / Q000652:urine; D014665:Vasodilator Agents / Q000652:urine*
chemical_list: D011453:Prostaglandins; D011458:Prostaglandins E; D014665:Vasodilator Agents; D013929:Thromboxane B2; D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha; C028290:2,3-dinor-6-ketoprostaglandin F1alpha; D011464:Epoprostenol; D015232:Dinoprostone