Thrombocytopenia: a complication of Kawasaki disease.
Thrombocytopenia was observed in 10 (2.0%) of 486 children with Kawasaki disease. In nine of the ten, the minimal platelet count of 94,000 +/- 38,000 (SD)/mm3 was seen on day 6.8 +/- 2.2 (SD) of illness and the platelet counts were elevated to the normal level in 1-2 weeks. Thrombocytopenia in the nine appeared to be caused via coagulation-mediated platelet consumption, while the remaining child was diagnosed as having idiopathic thrombocytopenic purpura. One of the two who had severe coagulation-mediated thrombocytopenia of less than 50,000/mm3 developed coronary aneurysms persisting over 1 year.
Hara
T
T
Department of Paediatrics, Faculty of Medicine, Kyushu University, Fukuoka city, Japan.
Mizuno
Y
Y
Akeda
H
H
Fukushige
J
J
Ueda
K
K
Aoki
T
T
Sunagawa
H
H
Honda
S
S
Hijii
T
T
Yamaguchi
Y
Y
D001241:Aspirin / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000209:etiology; D005260:Female; D005480:Flurbiprofen / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D008499:Medical Records; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000188:drug therapy; D010976:Platelet Count; D013921:Thrombocytopenia / Q000209:etiology*
D005480:Flurbiprofen; D001241:Aspirin