Treatment of iron deficiency conditions in blood donors: controlled study of iron sulphate versus iron protein succinylate.
Iron protein succinylate is a new iron preparation for oral administration. In a controlled study versus iron sulphate in 40 blood donors with low levels of stored iron, treatment for 30 days with iron protein succinylate resulted in greater iron absorption compared to the reference drug. Serum iron concentration significantly increased compared with baseline values only in patients given iron protein succinylate. The amount of stored iron, evaluated by serum ferritin levels, significantly increased in both treatment groups.
Landucci
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USL No. 6 Piana di Lucca, UO Immunohaematology and Blood Transfusion, Italy.
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D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000747:Anemia, Hypochromic / Q000097:blood / Q000188:drug therapy*; D001782:Blood Donors; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D005260:Female; D005293:Ferritins / Q000097:blood; D005296:Ferrous Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007501:Iron / Q000097:blood; D008297:Male; D008667:Metalloproteins / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011897:Random Allocation; D013386:Succinates / Q000008:administration & dosage / Q000627:therapeutic use*
D005296:Ferrous Compounds; D008667:Metalloproteins; D013386:Succinates; C020748:ferrous sulfate; D005293:Ferritins; D007501:Iron; C055066:iron protein succinylate