title: Treatment of depression in cancer patients is associated with better life adaptation: a pilot study.
abstract: Major depression occurs in a significant number of cancer patients, and there is evidence that cancer patients with depression do not receive adequate antidepressant treatment. In an uncontrolled pilot study, the authors assess the degree of depression and the quality of life after the initiation of antidepressant medication treatment in 12 depressed cancer patients who received adequate antidepressant drugs and in 10 depressed cancer patients who received inadequate antidepressant treatment. These preliminary findings suggest that cancer patients with major depression benefit from antidepressant medication treatment and may experience an improved psychosocial adjustment to cancer. Controlled clinical trials will be necessary to verify these preliminary findings.
authors.affiliation: Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27514.
authors.forename: D L
authors.initials: DL
authors.lastname: Evans
authors.forename: C F
authors.initials: CF
authors.lastname: McCartney
authors.forename: J J
authors.initials: JJ
authors.lastname: Haggerty
authors.forename: C B
authors.initials: CB
authors.lastname: Nemeroff
authors.forename: R N
authors.initials: RN
authors.lastname: Golden
authors.forename: J B
authors.initials: JB
authors.lastname: Simon
authors.forename: D
authors.initials: D
authors.lastname: Quade
authors.forename: V
authors.initials: V
authors.lastname: Holmes
authors.forename: M
authors.initials: M
authors.lastname: Droba
authors.forename: G A
authors.initials: GA
authors.lastname: Mason
mesh_terms: D000223:Adaptation, Psychological; D000275:Adjustment Disorders / Q000188:drug therapy* / Q000523:psychology; D000328:Adult; D000368:Aged; D005260:Female; D005833:Genital Neoplasms, Female / Q000523:psychology*; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008875:Middle Aged; D011581:Psychological Tests; D011788:Quality of Life; D012803:Sick Role
chemical_list: D007099:Imipramine