title: Amaurosis fugax in a Danish community: a prospective study.
abstract: A prospective study of amaurosis fugax was carried out in a Danish community (population 481,000); case ascertainment was based on the collaboration of practicing ophthalmologists and general practitioners. Over a 3-year period we registered 131 cases; the annual incidence of "first amaurosis fugax episodes coming to medical attention" was 8.6 and 6.2 per 100,000 population for men and women, respectively. On the basis of a comparison of the age-incidence curves for cerebral and retinal ischemic attacks, the "true" incidence of amaurosis fugax is estimated to be approximately 14/100,000/yr, or 25-30% of the reported incidence of transient ischemic attacks. Clinical and/or radiologic signs of a carotid lesion on the appropriate side were present in 56% of the patients, and an additional 27% had symptoms or signs of other organic cardiovascular disorders. Forty-three (68%) of the 63 patients who underwent arteriography had an atheromatous lesion apparently amenable to carotid endarterectomy. In spite of the case-finding procedures employed in the study, cases of amaurosis fugax suitable for carotid surgery were thus ascertained at a rate of only 3/100,000/yr. This suggests that surgical treatment of patients with retinal ischemic attacks is of minor importance as a preventive measure against stroke in the community.
authors.affiliation: Department of Neurology, Aalborg Hospital, Denmark.
authors.forename: C U
authors.initials: CU
authors.lastname: Andersen
authors.forename: J
authors.initials: J
authors.lastname: Marquardsen
authors.forename: B
authors.initials: B
authors.lastname: Mikkelsen
authors.forename: J H
authors.initials: JH
authors.lastname: Nehen
authors.forename: K K
authors.initials: KK
authors.lastname: Pedersen
authors.forename: T
authors.initials: T
authors.lastname: Vesterlund
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001766:Blindness / Q000453:epidemiology* / Q000209:etiology; D002318:Cardiovascular Diseases / Q000150:complications; D002340:Carotid Artery Diseases / Q000150:complications; D003718:Denmark; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies