[Complete change of the cell composition of the liver parenchyma following exposure to dipin and partial resection].
The phenomenon of total replacement of preexisting and damaged hepatocytes in mice were demonstrated by the method of autoradiography. Adult mice were injected an alkylating drug Dipin 2 h prior to partial hepatectomy and then proliferating cells were labelled by means of multiple injections of 14C-thymidine. Dipin in combination with mitotic stimulation induced multiple mitotic aberrations in proliferating hepatocytes resulting in degeneration, death and then elimination of prelabelled liver cells. New parenchymal tissue originated from non-labelled preneoplastic nodules. These hepatocyte nodules grew in size, propagated and 8-10 months later completely replaced the preexisting hepatocytes.
Uryvaeva
I V
IV
Faktor
V M
VM
D000477:Alkylating Agents / Q000506:poisoning*; D000818:Animals; D001388:Aziridines / Q000506:poisoning*; D001389:Azirines / Q000506:poisoning*; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects / Q000473:pathology* / Q000601:surgery; D008113:Liver Neoplasms / Q000473:pathology; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D011230:Precancerous Conditions / Q000473:pathology
D000477:Alkylating Agents; D001388:Aziridines; D001389:Azirines; C007526:dipin
Polnaia smena kletochnogo sostava parenkhimy pecheni posle vozdeĭstviia dipina i chastichnoĭ rezektsii.