Lipid peroxidation in the nuclear fraction of rat lungs induced by hydralazine.
Hydralazine (1-hydrazinophthalazine) was administered in drinking water as a 0.0312% solution to randomly bred female Wistar rats during 3 weeks. The average daily intake of this compound was 6.74 mg for a rat. The treatment resulted in lipid peroxidation in the nuclear fraction of the lungs. This lipid peroxidation was detected spectrophotometrically by the appearance of a peak at 233-235 nm in the spectrum of chloroform-methanol extract. The close proximity of DNA may make it a possible target for attack by free radicals.
Jendryczko
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A
Department of Biochemistry and Chemistry, Silesian Medical School, Katowice, Poland.
Drózdz
M
M
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D005609:Free Radicals; D006830:Hydralazine / Q000633:toxicity*; D008054:Lipid Peroxides / Q000378:metabolism*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013057:Spectrum Analysis
D005609:Free Radicals; D008054:Lipid Peroxides; D006830:Hydralazine