title: Glucose depletion hyperpolarizes guinea pig hippocampal neurons by an increase in potassium conductance.
abstract: Superfusion of guinea pig hippocampal brain slices with a glucose-free solution induced a membrane hyperpolarization and an increase in input conductance of neurons in the CA3 region. Under voltage clamp, glucose depletion induced an outward current with a reversal potential near the K+ equilibrium potential. The action of glucose depletion was different from the effect of ouabain, indicating that low-glucose-induced changes in the membrane conductance are primarily due to alterations in cell metabolism rather than due only to an inhibition of the Na+/K+ pump.
authors.affiliation: Department of Physiology, University of Munich, Federal Republic of Germany.
authors.forename: A
authors.initials: A
authors.lastname: Spuler
authors.forename: W
authors.initials: W
authors.lastname: Endres
authors.forename: P
authors.initials: P
authors.lastname: Grafe
mesh_terms: D000818:Animals; D004553:Electric Conductivity; D005947:Glucose / Q000378:metabolism*; D006168:Guinea Pigs; D006624:Hippocampus / Q000378:metabolism* / Q000502:physiology; D008564:Membrane Potentials; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D011188:Potassium / Q000502:physiology*
chemical_list: D005947:Glucose; D011188:Potassium