title: 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials.
authors.affiliation: Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.
authors.forename: J M
authors.initials: JM
authors.lastname: Domagala
authors.forename: S E
authors.initials: SE
authors.lastname: Hagen
authors.forename: C L
authors.initials: CL
authors.lastname: Heifetz
authors.forename: M P
authors.initials: MP
authors.lastname: Hutt
authors.forename: T F
authors.initials: TF
authors.lastname: Mich
authors.forename: J P
authors.initials: JP
authors.lastname: Sanchez
authors.forename: A K
authors.initials: AK
authors.lastname: Trehan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002939:Ciprofloxacin / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D011804:Quinolines; D002939:Ciprofloxacin