Candida vertebral osteomyelitis: report of three cases and a review of the literature.
We have recently treated three patients with Candida vertebral osteomyelitis. In each patient there was at least one characteristic prodromal condition, including trauma, multiple antibiotics following bowel surgery, and acute nonlymphocytic leukemia. All patients were treated successfully with amphotericin B. Based on our findings and a review of the literature, we would recommend a 1.0-1.2 gm total dosage of amphotericin B. Alternative therapeutic choices such as 5FC and/or ketoconazole, under specific clinical conditions, have been successfully employed. However, cure can best be confirmed by post-treatment biopsy.
Friedman
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BC
Department of Medicine, George Washington University Medical Center, Washington, D.C. 20037.
Simon
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GL
D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy*; D006801:Humans; D008159:Lumbar Vertebrae / Q000382:microbiology*; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology*; D013166:Spondylitis / Q000188:drug therapy / Q000382:microbiology*; D013904:Thoracic Vertebrae / Q000382:microbiology*
D000666:Amphotericin B