Lack of glomerular hemodynamic stimulation after infusion of branched-chain amino acids.
Renal hemodynamics (Inutest. CPAH) were studied in five adult volunteers infused on separate occasions with branched-chain amino acids (BCAA), a mixture of nonessential and essential amino acids of the same volume, osmolality and nitrogen content, and 0.9% saline solution. BCAA infusion caused moderate renal vasoconstriction, a slight increase of GFR and a progressive rise of the filtration fraction (FF), whereas the amino acids mixture induced a significantly higher increase of GFR and a state of renal vasodilatation without altering the FF. The volume expansion with 0.9% saline did not cause any notable hemodynamic modification except for reduced FF. This study demonstrates that whereas a state of hyperfiltration and hyperemia is specifically induced by an amino acid mixture independently of volume expansion and osmolar load, the administration of BCAA provides nitrogen without renal hemodynamic stimulation.
Claris-Appiani
A
A
Clinica Pediatrica II, University of Milan, Italy.
Assael
B M
BM
Tirelli
A S
AS
Marra
G
G
Cavanna
G
G
D000328:Adult; D000597:Amino Acids, Branched-Chain / Q000494:pharmacology*; D000601:Amino Acids, Essential / Q000494:pharmacology; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D012079:Renal Circulation / Q000187:drug effects*
D000597:Amino Acids, Branched-Chain; D000601:Amino Acids, Essential