Highly stable lanthanide macrocyclic complexes: in search of new contrast agents for NMR imaging.
This paper presents the views of a coordination chemist on the synthesis and the properties of new contrast agents containing gadolinium. Attention is drawn to various macrocyclic complexes such as the polyaza polycarboxylic chelates, the cryptates as well as compounds obtained by template synthesis. The structural factors influencing the kinetic and thermodynamic stability of the gadolinium complexes are discussed with special emphasis on the polyaza polycarboxylic derivatives. Some of the macrocyclic complexes under investigation are more stable than Gd-DTPA.
Desreux
J F
JF
Analytical and Radiochemistry, University of Liège, Belgium.
Barthélemy
P P
PP
D002614:Chelating Agents; D003287:Contrast Media / Q000138:chemical synthesis; D005682:Gadolinium; D006571:Heterocyclic Compounds / Q000138:chemical synthesis; D008279:Magnetic Resonance Imaging; D008674:Metals, Rare Earth; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis; D013329:Structure-Activity Relationship
D002614:Chelating Agents; D003287:Contrast Media; D006571:Heterocyclic Compounds; D008674:Metals, Rare Earth; D009942:Organometallic Compounds; D005682:Gadolinium