title: Double valve disease in systemic lupus erythematosus. Case report and literature review.
abstract: A young, nonhypertensive female with advanced systemic lupus erythematosus (SLE) presented in congestive cardiac failure due to aortic and mitral regurgitation. The valvular lesions resulted from organization of valvular pocket Libman-Sacks vegetations. Her clinical course mimicked infective endocarditis. She is only the third recorded patient with SLE valvular disease warranting double valve replacement. This patient, who had her valvular disease at presentation (prior to initiation of steroid therapy), illustrates that untreated SLE per se may produce severe organic valvular disease.
authors.affiliation: Department of Pathology, Groote Schuur, Cape Town, South Africa.
authors.forename: A G
authors.initials: AG
authors.lastname: Rose
authors.forename: F H
authors.initials: FH
authors.lastname: Spracklen
mesh_terms: D000293:Adolescent; D001022:Aortic Valve Insufficiency / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D008944:Mitral Valve Insufficiency / Q000209:etiology* / Q000473:pathology; D009206:Myocardium / Q000473:pathology