The disposal of intravenous glucose studied using glucose and insulin clamp techniques in sepsis and trauma in man.
Whole body glucose uptake and oxidation during a hyperglycemic clamp have been shown to be depressed in hypermetabolic septic patients compared to control subjects despite similar plasma insulin concentrations. Forearm glucose uptake was similarly impaired. Metabolic rate was not increased further by the glucose infusion in the patients although a 20% rise was elicited in the controls. This resistance to the effects of insulin was also clearly demonstrated in trauma patients using the euglycemic clamp technique. The maximal rate of glucose disposal after injury was half that found in controls and the pattern of response was consistent with the insulin resistance being a post-receptor defect.
Little
R A
RA
North Western Injury Research Centre, University of Manchester, U.K.
Henderson
A
A
Frayn
K N
KN
Galasko
C S
CS
White
R H
RH
D005947:Glucose / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007239:Infections / Q000378:metabolism*; D007263:Infusions, Parenteral; D007328:Insulin / Q000097:blood; D014947:Wounds and Injuries / Q000378:metabolism*
D007328:Insulin; D005947:Glucose