[Mechanism of the antimutagenic action of dibunol].
In experiments with cultured V-79 Chinese hamster cells a study was made of the influence of dibunol on the level of gamma-radiation-induced micronuclei and sedimentation properties of cell nucleoids during ultracentrifugation in a neutral sucrose gradient. Protection of DNA molecule against the effects of both primary and secondary damages was found to be involved in the mechanism of the protective action of dibunol.
Bakhitova
L M
LM
Kolonina
I V
IV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D002460:Cell Line; D002478:Cells, Cultured / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D009154:Mutation; D011831:Radiation Genetics; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D000975:Antioxidants; D011837:Radiation-Protective Agents; D002084:Butylated Hydroxytoluene
K voprosu o mekhanizme antimutagennogo deĭstviia dibunola.