title: Decreased postoperative myocardial fatty acid oxidation.
abstract: Myocardial substrate preferences following cardioplegic arrest for coronary bypass surgery have not been established. Fatty acids are believed to be the major fuel source for aerobic metabolism. Following cardioplegic arrest arterial fatty acid levels are elevated and myocardial fatty acid accumulation without oxidation may contribute to reperfusion injury. Perioperative fatty acid metabolism was evaluated in 18 patients undergoing elective coronary bypass surgery who were randomized to receive either blood (n = 11) or crystalloid (n = 7) cardioplegia. Palmitate labeled with 14carbon was infused perioperatively and arterial and coronary sinus blood samples were obtained to calculate myocardial fatty acid extraction and oxidation before and after cardioplegic arrest. Lactate and glycerol were released from the heart during both blood and crystalloid cardioplegia, suggesting ischemic glycolysis and lipolysis. Myocardial oxygen consumption was depressed and the myocardial consumptions of lactate, glucose, and fatty acids were minimal during the first 60 min after aortic clamp removal in both groups despite high arterial concentrations. Fatty acid oxidation was minimal after blood cardioplegia and was not found after crystalloid cardioplegia. Fatty acids were extracted by the heart, but were not aerobically metabolized following cardioplegic arrest. Myocardial fatty acid accumulation without oxidation may have been deleterious. The inability of the heart to oxidize exogenous fatty acids may reflect altered myocardial exogenous substrate preferences during reperfusion following coronary bypass surgery.
authors.affiliation: Division of Cardiovascular Surgery, Toronto General Hospital, Ontario, Canada.
authors.forename: K H
authors.initials: KH
authors.lastname: Teoh
authors.forename: D A
authors.initials: DA
authors.lastname: Mickle
authors.forename: R D
authors.initials: RD
authors.lastname: Weisel
authors.forename: S E
authors.initials: SE
authors.lastname: Fremes
authors.forename: G T
authors.initials: GT
authors.lastname: Christakis
authors.forename: A D
authors.initials: AD
authors.lastname: Romaschin
authors.forename: R S
authors.initials: RS
authors.lastname: Harding
authors.forename: M M
authors.initials: MM
authors.lastname: Madonik
authors.forename: J
authors.initials: J
authors.lastname: Ivanov
mesh_terms: D002314:Cardioplegic Solutions; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D006324:Heart Arrest, Induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D011188:Potassium; D017680:Potassium Compounds
chemical_list: D002314:Cardioplegic Solutions; D005230:Fatty Acids, Nonesterified; D017680:Potassium Compounds; C018369:potassium cardioplegic solution; D011188:Potassium