Risk of malignant lymphoma in Swedish agricultural and forestry workers.
The risk of malignant lymphoma after possible exposure to phenoxy acid herbicides was studied in 354,620 Swedish men who, according to a national census in 1960, were employed in agriculture or forestry. The cohort was divided into subcohorts according to assumed exposure and compared with 1,725,645 Swedish men having other economic activities. All were followed up in the Cancer-Environment Register between 1961 and 1979. Non-Hodgkin lymphoma was found in 861 men in the study cohort. The relative risk was not significantly increased in any subcohort, did not differ significantly between the subcohorts, and showed no time related increase in the total cohort or any subcohort. Hodgkin's disease was found in 355 men in the study cohort. Relative risks significantly higher than unity were found among fur farming and silviculture workers where the relative risks were 4.45 and 2.26, respectively. All five cases in the former group were engaged in mink farming. A time related rising trend in relative risk was found in the silviculture subcohort. Elsewhere the relative risk did not diverge from unity and no time related trend was discernible.
Wiklund
K
K
Department of Cancer Epidemiology, Karolinska Hospital and Institute, Stockholm, Sweden.
Lindefors
B M
BM
Holm
L E
LE
D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000009:adverse effects; D015084:2,4-Dichlorophenoxyacetic Acid / Q000009:adverse effects; D000382:Agricultural Workers' Diseases / Q000139:chemically induced*; D006016:Glycolates / Q000009:adverse effects*; D006540:Herbicides / Q000009:adverse effects*; D006689:Hodgkin Disease / Q000139:chemically induced; D006801:Humans; D008223:Lymphoma / Q000139:chemically induced*; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced; D008297:Male; D010642:Phenoxyacetates / Q000009:adverse effects*; D012307:Risk Factors; D013548:Sweden; D014197:Trees
D006016:Glycolates; D006540:Herbicides; D010642:Phenoxyacetates; D015084:2,4-Dichlorophenoxyacetic Acid; D015085:2,4,5-Trichlorophenoxyacetic Acid