title: Kinetic-effect models and their applications.
abstract: This article focuses on mathematical models that analyze the time course of drug effects in humans. Any such model, whether parametric or nonparametric, is termed a kinetic-effect model (KEM). These models serve to describe (interpolation) and to predict (extrapolation) the effect-time profile. KEMs are applicable to many problems in pharmaceutics, pharmacology, and clinical pharmacology.
authors.affiliation: Department of Pharmacology, University of Texas Medical School, Houston 77030.
authors.forename: J
authors.initials: J
authors.lastname: Grevel
mesh_terms: D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D010601:Pharmacology, Clinical / Q000379:methods*