Adrenal dopamine content of the developing rat. Influence of the thyroid status and insulin-hypoglycaemia.
Neonatal hypothyroidism accelerates the postnatal evolution of the adrenal dopamine (DA) content and concentration in the young rat. In 14-day-old control animals, insulin-hypoglycaemia leads to a transient increase in adrenal dopamine content up to 159% above the value in saline-injected animals. This increase is already at its maximum 1 h after insulin administration and lasts 7 h. In the hypothyroid animals, the DA increase evoked by hypoglycaemia is impaired in magnitude (74%) and duration (4 h).
Gripois
D
D
Laboratoire d'Endocrinologie, Université Paris-Sud, Orsay, France.
Valens
M
M
Richter
P
P
Genermont
J
J
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D007003:Hypoglycemia / Q000139:chemically induced / Q000378:metabolism*; D007037:Hypothyroidism / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D007328:Insulin; D008297:Male; D011441:Propylthiouracil; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000502:physiology*; D014284:Triiodothyronine / Q000097:blood / Q000627:therapeutic use
D007328:Insulin; D014284:Triiodothyronine; D011441:Propylthiouracil; D004298:Dopamine