Cerebral energy metabolism following fluid-percussion brain injury in cats.
Clinical and experimental evidence suggests that head injury can cause alterations of cerebral energy metabolism. However, the etiology of this metabolic perturbation is not known. The objective of this study was to determine the effect of fluid-percussion trauma on cerebral energy metabolism. Seven ventilated, chloralose-anesthetized cats were subjected to a 3.2-atm fluid-percussion brain injury. Before and for 8 hours after trauma, continuous phosphorus-3 1 magnetic resonance spectrography was obtained to noninvasively monitor tissue pH, phosphocreatine (PCr), and inorganic phosphate (Pi) levels. Measurement of cerebral blood flow (CBF) by the radioactive microsphere technique and calculation of oxygen and glucose consumption (CMRO2 and CMRG1) were also performed before trauma as well as 30 minutes and 1, 2, 4, and 8 hours after trauma. The data showed a moderate decrease in tissue pH from 7.04 to 6.89 at 30 minutes following trauma with return to control levels by 3 hours posttrauma. During the 8-hour observation period, CBF, CMRO2, and CMRG1 remained at control levels. Tissue PCr and Pi levels were also unchanged. Fluid-percussion trauma at the 3.2-atm level in ventilated cats causes a moderate and transient decrease in tissue pH that returns to control levels after trauma. No other metabolic changes are seen later than 30 minutes posttrauma. This indicates that a mild metabolic disturbance occurs after trauma in the ventilated animal and quickly returns to normal.
Unterberg
A W
AW
Richard Roland Reynolds Neurosurgical Research Laboratories, Department of Surgery, Richmond, Virginia.
Andersen
B J
BJ
Clarke
G D
GD
Marmarou
A
A
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002415:Cats; D002560:Cerebrovascular Circulation; D004734:Energy Metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010101:Oxygen Consumption; D010474:Percussion; D014949:Wounds, Nonpenetrating / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology
D005947:Glucose