Effects of the two new anthelmintic agents CGP 6140 and CGP 20376 on adult Paragonimus uterobilateralis in the experimental host Sigmodon hispidus.
The new compounds CGP 6140 and CGP 20376 were tested for their anthelmintic activity against adult Paragonimus uterobilateralis in experimentally infected Sigmodon hispidus. Both drugs were effective at a dosage of 2 x 100 mg/kg b.w. given orally with an interval of six hours between the doses. This regimen killed 80% of the flukes collected on Days 7 and 11 after treatment with CGP 6140 and 100% of the flukes collected on Days 5, 7, and 11 after therapy with CGP 20376. Both compounds showed no effect at single doses of 25, 50 and 100 mg/kg or with 12.5 and 25 mg/kg/day given on four consecutive days.
Weber
P
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Department of Helminthology, Bernhardt Nocht Institute, Hamburg, Germany.
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D003411:Arvicolinae; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010237:Paragonimiasis / Q000188:drug therapy*; D010238:Paragonimus / Q000187:drug effects; D010879:Piperazines / Q000627:therapeutic use*; D013844:Thiazoles / Q000627:therapeutic use*
D000871:Anthelmintics; D010879:Piperazines; D013844:Thiazoles; C051745:CGP 20376; C051744:amocarzine