title: Disproportionate epicardial dilation after transmural infarction of the canine left ventricle: acute and chronic differences.
abstract: The relation between acute disproportionate infarct dilation and late postinfarct left ventricular remodeling was examined by implanting multiple radiopaque epicardial markers in the left ventricle of eight dogs and determining regional surface deformation after acute and chronic transmural infarction. Transmural injury was produced by combining coronary ligation with distal embolization of a rubber polymer. Dogs were anesthetized and studied before and 1 h, 24 h and 1 week after infarction. Marker positions were recorded by rapid biplane cineradiography, and three-dimensional coordinates were reconstructed by a computer-assisted tracking system. Regional deformation was expressed by a local surface area equal to the sum of multiple (three to four) triangles generated by marker triplets. As early as 1 h after infarction, end-diastolic area in the infarct region increased by 20.3 +/- 3.1%, while that in the remote region increased by only 7.9 +/- 3.5%. Both changes and the difference between them were significant. At 24 h after infarction, both territories continued to undergo dilation, this time to a similar extent (additional +10.3% in the remote region and +10.1% in the infarct region), thus maintaining the significant disproportionate infarct dilation. At 1 week, however, the infarct territory remained dilated with a mean end-diastolic area 31.4 +/- 3.1% above control, while that in the remote region returned to a net mean 8.5 +/- 4.7% increase. Thus, the major extent of disproportionate infarct dilation occurs within 1 h after transmural injury and is accompanied by remote dilation as a compensatory response. The extent of further infarct dilation achieved by 24 h is maintained in the chronic infarct, and compensatory mechanisms enable noninjured myocardium to become less dilated.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
authors.forename: D A
authors.initials: DA
authors.lastname: Kass
authors.forename: W L
authors.initials: WL
authors.lastname: Maughan
authors.forename: A
authors.initials: A
authors.lastname: Ciuffo
authors.forename: W
authors.initials: W
authors.lastname: Graves
authors.forename: B
authors.initials: B
authors.lastname: Healy
authors.forename: M L
authors.initials: ML
authors.lastname: Weisfeldt
mesh_terms: D000818:Animals; D002933:Cineradiography; D004108:Dilatation, Pathologic / Q000473:pathology; D004285:Dogs; D006321:Heart / Q000000981:diagnostic imaging; D006352:Heart Ventricles; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000473:pathology* / Q000503:physiopathology; D010496:Pericardium / Q000473:pathology*; D013997:Time Factors