title: The beagle: an appropriate experimental animal for extrapolating the organ distribution pattern of Th in humans.
abstract: The concentrations and the organ distribution patterns of 228Th, 230Th and 232Th in two 9-y-old dogs of our beagle colony were determined. The dogs were exposed only to background environmental levels of Th isotopes through ingestion (food and water) and inhalation as are humans. The organ distribution patterns of the isotopes in the beagles were compared to the organ distribution patterns in humans to determine if it is appropriate to extrapolate the beagle organ burden data to humans. Among soft tissues, only the lungs, lymph nodes, kidney and liver, and skeleton contained measurable amounts of Th isotopes. The organ distribution pattern of Th isotopes in humans and dog are similar, the majority of Th being in the skeleton of both species. The average skeletal concentrations of 228Th in dogs were 30 to 40 times higher than the average skeletal concentrations of the parent 232Th, whereas the concentration of 228Th in human skeleton was only four to five times higher than 232Th. This suggests that dogs have a higher intake of 228Ra through food than humans. There is a similar trend in the accumulations of 232Th, 230Th and 228Th in the lungs of dog and humans. The percentages of 232Th, 230Th and 228Th in human lungs are 26, 9.7 and 4.8, respectively, compared to 4.2, 2.6 and 0.48, respectively, in dog lungs. The larger percentages of Th isotopes in human lungs may be due simply to the longer life span of humans. If the burdens of Th isotopes in human lungs are normalized to an exposure time of 9.2 y (mean age of dogs at the time of sacrifice), the percent burden of 232Th, 230Th and 228Th in human lungs are estimated to be 3.6, 1.3 and 0.66, respectively. These results suggest that the beagle may be an appropriate experimental animal for extrapolating the organ distribution pattern of Th in humans.
authors.affiliation: Radiobiology Division, School of Medicine, University of Utah, Salt Lake City 84112.
authors.forename: N P
authors.initials: NP
authors.lastname: Singh
authors.forename: C J
authors.initials: CJ
authors.lastname: Zimmerman
authors.forename: G N
authors.initials: GN
authors.lastname: Taylor
authors.forename: M E
authors.initials: ME
authors.lastname: Wrenn
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000396:Air Pollutants, Radioactive / Q000008:administration & dosage; D000818:Animals; D004285:Dogs / Q000378:metabolism*; D005260:Female; D005507:Food Contamination, Radioactive; D006801:Humans; D008297:Male; D013910:Thorium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014875:Water Pollutants, Radioactive / Q000008:administration & dosage
chemical_list: D000396:Air Pollutants, Radioactive; D014875:Water Pollutants, Radioactive; D013910:Thorium