title: Ketanserin and the cardiovascular response to intubation: a preliminary report.
abstract: Several methods of attenuating the adverse cardiovascular effects of laryngoscopy and intubation are available. The obtunding effect of ketanserin 0.5 mg kg-1 versus that of a placebo, given 5 min prior to intubation, was investigated in a randomized double-blind trial in a group of 40 patients. Blood pressure (systolic, mean and diastolic) and pulse rate were measured at 1-min intervals with an Accutor blood pressure apparatus for 5 min before and 5 min after the injection of ketanserin or placebo, as well as for 6 min after a standardized induction (thiopentone and suxamethonium), laryngoscopy and intubation. The patients who had received ketanserin had a statistically significant lower systolic blood pressure (1 and 4 min), as well as significantly lower mean and diastolic blood pressures at 1, 2, 3 and 4 min. There were no unexpected untoward side-effects. Further investigations are suggested using ketanserin as part of a multi-faceted pharmacological approach to decrease the adverse effects of laryngoscopy and intubation.
authors.affiliation: Department of Anaesthesia, Faculty of Medicine, University of Stellenbosch, Tygerberg, Republic of South Africa.
authors.forename: W B
authors.initials: WB
authors.lastname: Murray
authors.forename: C H
authors.initials: CH
authors.lastname: Daniel
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000517:prevention & control*; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D007650:Ketanserin / Q000627:therapeutic use*; D008297:Male; D011897:Random Allocation; D013312:Stress, Physiological / Q000188:drug therapy* / Q000209:etiology
chemical_list: D007650:Ketanserin