title: Twin vessels in von Hippel-Lindau disease.
abstract: We examined ten patients from three families with von Hippel-Lindau disease and 26 of their at-risk relatives for the presence of twin vessels, defined as a paired retinal arteriole and venule that are separated by less than the diameter of one venule and extend for a distance of more than one disk diameter. They were compared with 36 age- and sex-matched controls. Of the 36 subjects in the study group, 23 had twin vessels compared with two controls (P less than 10(-6). Of the ten patients, nine (14 eyes) had twin vessels; no twin vessels were found in their controls (P = 5.9 x 10(-5)). Fourteen at-risk relatives and two of their controls had twin vessels (P = 9.4 x 10(-4)).
authors.affiliation: Department of Ophthalmology, Erasmus University, Rotterdam, The Netherlands.
authors.forename: P T
authors.initials: PT
authors.lastname: de Jong
authors.forename: R J
authors.initials: RJ
authors.lastname: Verkaart
authors.forename: M J
authors.initials: MJ
authors.lastname: van de Vooren
authors.forename: D F
authors.initials: DF
authors.lastname: Majoor-Krakauer
authors.forename: A R
authors.initials: AR
authors.lastname: Wiegel
mesh_terms: D000328:Adult; D000798:Angiomatosis / Q000235:genetics* / Q000473:pathology; D005134:Eye Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D010375:Pedigree; D012160:Retina / Q000473:pathology*; D012171:Retinal Vessels / Q000002:abnormalities / Q000473:pathology*; D012307:Risk Factors