Effect of di(2-ethylhexyl)phthalate (DEHP) on hepatic mixed function oxidases in different animal species.
Administration of 2000 mg/kg of di(2-ethylhexyl)phthalate (DEHP) for a period of 7 or 15 days in rats, mice, guinea pigs and rabbits produced a differential effect as judged by alterations in body weight gain, liver weight and activities of mixed function oxidases. DEHP exposure for 7 days caused an increase in the activity of aniline hydroxylase, arylhydrocarbon hydroxylase and ethylmorphine N-demethylase in rats, mice and guinea pigs, but a decrease in that of rabbits. However, exposure for 15 days produced a smaller degree of increase in the activity of these enzymes in rats and mice and even produced a decrease in the activity of these enzymes in guinea pigs. This differential response of DEHP in various animal species suggests a species difference in the toxicity of the plasticizer.
Parmar
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Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
Srivastava
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SP
Seth
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PK
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004051:Diethylhexyl Phthalate / Q000378:metabolism / Q000633:toxicity*; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D006899:Mixed Function Oxygenases / Q000032:analysis*; D010795:Phthalic Acids / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D010795:Phthalic Acids; D004051:Diethylhexyl Phthalate; D006899:Mixed Function Oxygenases