Automated sequence reading and analysis.
We report on a system developed by Bio-Rad Laboratories, Inc. which combines automated reading of DNA sequencing autoradiograms with comprehensive software for shotgun overlapping of the readings, analysis of the sequences derived and searching of databases. Reading is accomplished using a high speed optical scanner and pattern recognition software operating on a personal computer. Overlapping, analysis and database searching software each incorporate significant advances over prior systems.
West
J
J
Bio-Rad Laboratories, Philadelphia, PA 19104.
D000465:Algorithms; D001345:Autoradiography / Q000295:instrumentation / Q000379:methods; D001483:Base Sequence; D003201:Computers; D004587:Electrophoresis, Agar Gel; D007256:Information Systems; D008838:Microcomputers; D010363:Pattern Recognition, Automated; D012984:Software / Q000379:methods*