Recurrent hypercalcemia and elevated 1,25-dihydroxyvitamin D levels in Hodgkin's disease.
Hypercalcemia has been infrequently associated with Hodgkin's disease. When seen, most cases have been attributable to skeletal invasion by disease. Herein is described a 40-year-old man with a 15-year history of Hodgkin's disease. Each of four disease recurrences was heralded by hypercalcemia occurring in the absence of bone disease or elevation of parathyroid hormone levels. Marked elevations of 1,25-dihydroxyvitamin D levels were observed that paralleled his disease course and response to therapy. The repetitive association of hypercalcemia with an elevation of 1,25-dihydroxyvitamin D in this case provides further evidence of lymphoma-associated production of this vitamin.
Mercier
R J
RJ
Department of Medicine, Wilford Hall United States Air Force Medical Center, San Antonio, Texas 78236-5300.
Thompson
J M
JM
Harman
G S
GS
Messerschmidt
G L
GL
D000328:Adult; D004100:Dihydroxycholecalciferols / Q000096:biosynthesis / Q000097:blood*; D006689:Hodgkin Disease / Q000150:complications* / Q000378:metabolism; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008297:Male
D004100:Dihydroxycholecalciferols