title: Lack of effect of dihydroergotamine on endothelial and smooth muscle cell proliferation and endothelial cell prostanoid production.
abstract: The most important effect of dihydroergotamine is venoconstriction, but certain metabolic effects and changes in vessel prostanoid activity have also been suggested. In this study endothelial cell production of 6-keto PGF1 alpha and TxB2 was quantitated in vitro. No evidence of altered prostanoid production was noted after incubation with dihydroergotamine (exposure ranging from 5 x 10(-3) to 5 x 10(-7) g/l). Similarly, no effect of dihydroergotamine on the growth rates of endothelial cells or smooth muscle cells in vitro was documented.
authors.affiliation: Department of Surgery, University of Michigan Medical School, Ann Arbor.
authors.forename: B
authors.initials: B
authors.lastname: Lindblad
authors.forename: W E
authors.initials: WE
authors.lastname: Burkel
authors.forename: T W
authors.initials: TW
authors.lastname: Wakefield
authors.forename: L M
authors.initials: LM
authors.lastname: Graham
authors.forename: J C
authors.initials: JC
authors.lastname: Stanley
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004087:Dihydroergotamine / Q000494:pharmacology*; D004285:Dogs; D004730:Endothelium, Vascular / Q000166:cytology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D011453:Prostaglandins / Q000096:biosynthesis*; D013929:Thromboxane B2 / Q000096:biosynthesis
chemical_list: D011453:Prostaglandins; D004087:Dihydroergotamine; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha