title: Altered metabolic function of the pulmonary microcirculation. Early detection of lung injury and possible functional significance.
abstract: The normal lung is the site of intense metabolic activity, largely associated with the endothelial cell. Depressed pulmonary metabolic function is seen in a wide variety of experimental animal models of acute lung injury, and is also demonstrated in ARDS patients. The evaluation of lung metabolic activity may prove to be a sensitive probe for the detection of the earliest phases of acute lung injury, as well as a guide to the severity of injury or response to therapy. Depressed lung metabolic function may play a role in the intrapulmonary and/or systemic pathophysiology of ARDS.
authors.affiliation: Department of Pulmonary Disease, Cleveland Clinic Foundation, Ohio.
authors.forename: H P
authors.initials: HP
authors.lastname: Wiedemann
authors.forename: C N
authors.initials: CN
authors.lastname: Gillis
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000378:metabolism; D000809:Angiotensins / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001920:Bradykinin / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000098:blood supply* / Q000378:metabolism; D008833:Microcirculation / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism; D012128:Respiratory Distress Syndrome / Q000378:metabolism* / Q000503:physiopathology; D014666:Vasomotor System / Q000503:physiopathology
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000809:Angiotensins; D001679:Biogenic Amines; D011453:Prostaglandins; D001920:Bradykinin