Ejaculatory failure and urinary dysfunction secondary to labetalol.
We describe 3 men with moderate to severe essential hypertension in whom ejaculatory failure developed after therapy with labetalol, an antihypertensive drug with alpha-1 and beta-adrenergic blocking properties. No decrease in libido or erectile dysfunction was reported by any of the patients. Previous and subsequent antihypertensive therapy with either alpha or beta-adrenergic blocking agents failed to cause similar symptoms. These findings reveal a unique spectrum of genitourinary dysfunction associated with the multireceptor blocking properties of labetalol.
O'Meara
J
J
Hypertension Unit, University of Connecticut School of Medicine, Farmington.
White
W B
WB
D000328:Adult; D004542:Ejaculation / Q000187:drug effects*; D006801:Humans; D007741:Labetalol / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D014555:Urination Disorders / Q000139:chemically induced*
D007741:Labetalol