Effects of L-carnitine infusion on intralipid clearance and utilization. Study carried out in septic patients of an intensive care unit.
Endogenous and exogenous supplies of carnitine are decreased in septic patients under total parenteral nutrition, while carnitine urinary elimination is increased. But the increase of lipid role in the energetic cover requires a greater intervening role of tissue carnitine. So one may hope that in septic patients additional supply of L-carnitine would increase the catabolism of infused lipids. Twenty-eight septic patients, admitted in an intensive care unit were given parenteral nutrition (200 g of glucose, 12.5 g of N/24 hr). On the day of the study, 250 ml of Intralipid 20% (Kabi Vitrum) were administered in 4 hr. During the same period 13 patients were infused with 2 g of L-carnitine (Sigma-Tau). The remaining 15 patients constituted the control group. Basic plasma levels of triglycerides, nonesterified fatty acids, free glycerol, phospholipids, and ketone bodies remained within physiological limits. They increased during the lipid infusion and returned to initial values, 4 hr after the end of the infusion. Free and total carnitine levels and free/total carnitine ratio were comparable to healthy subjects' reference values. These parameters increased during L-carnitine infusion. This infusion had no effect on exogenous lipid clearance. However, it seemed to increase the uptake and the hepatic oxidation of circulating fatty acids. It invalidated the increase of lactate and pyruvate that had been noticed when lipids were solely infused.
Gibault
J P
JP
Service de Réanimation, Hôtel-Dieu, Lyon, France.
Frey
A
A
Guiraud
M
M
Schirardin
H
H
Bouletreau
P
P
Bach
A C
AC
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000097:blood / Q000378:metabolism*; D002331:Carnitine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005217:Fat Emulsions, Intravenous / Q000378:metabolism / Q000493:pharmacokinetics*; D005227:Fatty Acids / Q000378:metabolism / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007362:Intensive Care Units; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood / Q000493:pharmacokinetics
D005217:Fat Emulsions, Intravenous; D005227:Fatty Acids; D014280:Triglycerides; D002331:Carnitine