title: [Macrophage activation induced by a synthetic antioxidant].
abstract: The effect of a synthetic antioxidant 2-tretbutyl-3-hydroxypyridine (TBHP) on the function of murine peritoneal macrophages (MP) has been studied. A direct contact of TBHP with MP in vitro increased the activity of a key enzyme of glucose monophosphate graft--glucose-6-phosphate dehydrogenase and the proportion of flattened MP. as compared to the control. Upon intraperitoneal MP injection the number of MP's in the abdominal cavity of mice increased. They differed from control MP's in enhanced flattening and phagocytosis. In mice with preinduced defect of abdominal clearance TBHP contributed to the recovery of the normal level of antibacterial protection. In all the in vitro and in vivo tests studying its activating effect on MP, the synthetic antioxidant was not inferior to the standard MP activator--bacterial lipopolysaccharide.
authors.forename: I S
authors.initials: IS
authors.lastname: Freĭdlin
authors.forename: N K
authors.initials: NK
authors.lastname: Artemenko
authors.forename: T S
authors.initials: TS
authors.lastname: Freĭdlin
authors.forename: I G
authors.initials: IG
authors.lastname: Shcherbak
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Danilevskiĭ
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001202:Ascitic Fluid / Q000166:cytology; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008262:Macrophage Activation / Q000187:drug effects*; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects; D011725:Pyridines / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D011725:Pyridines; C054909:2-tert-butyl-3-hydroxypyridine; D005954:Glucosephosphate Dehydrogenase
vernacular_title: Aktivatsiia makrofagov pod vliianiem sinteticheskogo antioksidanta.