Distribution of lidocaine and disopyramide in human blood and tissue, a case report of death caused by spinal anesthesia.
An 11-year-old girl was anesthetized with hyper-baric solution of lidocaine as spinal anesthesia for an appendectomy in a surgical clinic. Respiratory arrest which occurred soon after the injection, was not discovered for a period of time. Since spontaneous respiration recovered within 2 h of intensive resuscitation, the patient was transferred to a community hospital for intensive care. Ten hours after the spinal anesthesia, she died of cardiac failure. The concentration of lidocaine in the brain was 5-10 times more than that in other tissues. The relationship between the possibility of malpractice of spinal anesthesia and tissue distribution of the drug was discussed. In addition to lidocaine, a toxic amount of disopyramide, an antiarrhythmic drug, was detected in the body. The distribution of disopyramide was also estimated, and the pharmacokinetics of disopyramide in plasma and tissues were studied experimentally in rats.
Sakata
K
K
Department of Legal Medicine, Sapporo Medical College, Japan.
Ishigaki
S
S
Sakata
M
M
D000775:Anesthesia, Spinal / Q000401:mortality*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002648:Child; D004206:Disopyramide / Q000493:pharmacokinetics* / Q000506:poisoning; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008012:Lidocaine / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D011921:Rats, Inbred WKY; D012131:Respiratory Insufficiency / Q000139:chemically induced; D014018:Tissue Distribution
D008012:Lidocaine; D004206:Disopyramide