Anti-inflammatory activity of oleoresin from Brazilian Copaifera.
The oleoresin from Brazilian Copaifera species yielded copalic acid and sesquiterpenes and showed marked anti-inflammatory activity using various experimental models in rats. The oleoresin significantly inhibited carrageenin-induced pedal edema following oral doses from 0.70 to 2.69 ml/kg, but was somewhat less effective than 50 mg/kg calcium phenylbutazone. Repeated administration of the oleoresin at a dose of 1.26 ml/kg for a 6-day period reduced granuloma formation with a response comparable to that of 20 mg/kg of calcium phenylbutazone. This same dose of oleoresin also reduced the vascular permeability to intracutaneous histamine. The LD50 value of the oleoresin in rats was estimated to be 3.79 (3.21-4.47) ml/kg.
Basile
A C
AC
Department of Pharmacology, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Brazil.
Sertié
J A
JA
Freitas
P C
PC
Zanini
A C
AC
D000818:Animals; D000893:Anti-Inflammatory Agents; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D003368:Gossypium; D006099:Granuloma / Q000139:chemically induced / Q000517:prevention & control; D006632:Histamine / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; C018620:oleoresins; D006632:Histamine; D002351:Carrageenan