Acute acquired demyelinating polyneuropathy with respiratory failure following high-dose systemic cytosine arabinoside and marrow transplantation.
Reversible ventilatory failure secondary to acute, acquired polyneuropathy developed in a patient undergoing marrow transplantation for chronic myelogenous leukemia. The onset of the neuropathy was temporally related to the conditioning regimen of high-dose, systemic cytosine arabinoside (Ara-C). The clinical features and course were consistent with the Guillain-Barré syndrome and no other conditions causally associated with the syndrome were noted. Although central nervous system toxicity is a well recognized complication of high-dose Ara-C, peripheral neuropathy is infrequently reported. Possible mechanisms of peripheral polyneuropathy in this marrow transplant recipient are discussed.
Johnson
N T
NT
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
Crawford
S W
SW
Sargur
M
M
D000328:Adult; D016026:Bone Marrow Transplantation; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects*; D003711:Demyelinating Diseases / Q000209:etiology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D008297:Male; D011129:Polyradiculoneuropathy / Q000209:etiology*
D003561:Cytarabine