title: Cytotoxic effects of a leukocidin from Fusobacterium necrophorum on bovine hepatic cells.
abstract: Cytotoxic effects of a leukocidin from Fusobacterium necrophorum were demonstrated on bovine hepatic cells. The cytotoxic response was dose-dependent and could be inhibited by homologous antiserum. Scanning electron microscopy revealed damaged hepatic cell surface. These findings indicated a pathogenic role of the leukocidin in F. necrophorum infections.
authors.affiliation: Department of Veterinary Microbiology and Hygiene, Faculty of Agriculture, Yamaguchi University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ishii
authors.forename: M
authors.initials: M
authors.lastname: Kanoe
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Kai
authors.forename: H
authors.initials: H
authors.lastname: Blobel
mesh_terms: D000818:Animals; D002417:Cattle; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D002470:Cell Survival / Q000187:drug effects; D005674:Fusobacterium Infections / Q000473:pathology; D005675:Fusobacterium necrophorum / Q000032:analysis*; D066298:In Vitro Techniques; D007956:Leukocidins / Q000302:isolation & purification / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D009336:Necrosis
chemical_list: D007956:Leukocidins