Human hTM alpha gene: expression in muscle and nonmuscle tissue.
We have isolated a cDNA clone from a human skeletal muscle library which contains the complete protein-coding sequence of a skeletal muscle alpha-tropomyosin. This cDNA sequence defines a fourth human tropomyosin gene, the hTM alpha gene, which is distinct from the hTMnm gene encoding a closely related isoform of skeletal muscle alpha-tropomyosin. In cultured human fibroblasts, the hTM alpha gene encodes both skeletal-muscle- and smooth-muscle-type alpha-tropomyosins by using an alternative mRNA-splicing mechanism.
MacLeod
A R
AR
Ludwig Institute for Cancer Research, MRC Centre, Cambridge, United Kingdom.
Gooding
C
C
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D005347:Fibroblasts / Q000502:physiology; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D009132:Muscles / Q000502:physiology*; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics; D014018:Tissue Distribution; D014335:Tropomyosin / Q000235:genetics*
D012333:RNA, Messenger; D014335:Tropomyosin