Energy-dependent efflux mediated by class L (tetL) tetracycline resistance determinant from streptococci.
The class L (TetL) tetracycline resistance determinant from streptococci specified resistance and an energy-dependent decreased accumulation of tetracycline in both Streptococcus faecalis and Escherichia coli. Using E. coli, we showed that the reduced uptake resulted from active efflux. The streptococcal class M determinant, known to render the protein synthesis machinery of S. faecalis resistant to tetracycline inhibition, did not alter tetracycline transport in either host.
McMurry
L M
LM
Department of Molecular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111.
Park
B H
BH
Burdett
V
V
Levy
S B
SB
D004734:Energy Metabolism / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects*; D013753:Tetracycline Resistance; D013754:Tetracyclines / Q000494:pharmacology*
D013754:Tetracyclines