Enterohepatic circulation of NY-198, a new difluorinated quinolone, in rats.
Enterohepatic circulation of NY-198 in rats was studied. NY-198 glucuronide in the bile was rapidly hydrolyzed to NY-198 by the intestinal contents. Hydrolyzed and parent NY-198 in the bile were reabsorbed from the intestine. The amount of NY-198 in enterohepatic circulation was 59.8% of that excreted in the bile.
Saito
A
A
College of Medical Technology, Hokkaido University, Sapporo, Japan.
Nagata
O
O
Takahara
Y
Y
Okezaki
E
E
Yamada
T
T
Ito
Y
Y
D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D001646:Bile / Q000378:metabolism; D004764:Enterohepatic Circulation; D024841:Fluoroquinolones; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D011804:Quinolines / Q000493:pharmacokinetics*; D015363:Quinolones; D051381:Rats; D011919:Rats, Inbred Strains
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D011804:Quinolines; D015363:Quinolones; C053091:lomefloxacin