title: Antibody response to bacterial antigens covalently bound to biodegradable polymerized serum albumin beads.
abstract: Model vaccines have been made by covalently linking Clostridium botulinum type D toxin and Klebsiella pneumoniae capsular polysaccharide antigen to polymerized rabbit serum albumin beads. When injected into rabbits these bead vaccines induced an enhanced production of specific humoral antibody without causing adverse reactions. The adjuvant effect is due to a slow release from the bead structure and offers an alternative to oil emulsions and mineral salt adsorbents.
authors.affiliation: Department of Microbiology, Rhodes University, Grahamstown, South Africa.
authors.forename: C
authors.initials: C
authors.lastname: Langhein
authors.forename: J F
authors.initials: JF
authors.lastname: Newman
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000942:Antigens, Bacterial / Q000276:immunology*; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D001905:Botulinum Toxins / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007074:Immunoglobulin G / Q000096:biosynthesis; D007711:Klebsiella pneumoniae / Q000276:immunology*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011108:Polymers; D011135:Polysaccharides, Bacterial / Q000276:immunology; D011817:Rabbits; D012709:Serum Albumin
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D007074:Immunoglobulin G; D011108:Polymers; D011135:Polysaccharides, Bacterial; D012709:Serum Albumin; D001905:Botulinum Toxins