title: Amphotericin B dosage for disseminated candidiasis in premature infants.
abstract: Amphotericin B (Amp-B) serum concentrations were determined in five infants with disseminated candidiasis. All patients had positive blood cultures for Candida and one patient had Candida albicans meningitis. Amp-B sterilized the blood and the cerebrospinal fluid within four to nine days. Total doses of Amp-B varied from 11.6-62.3 mg. There was no laboratory or clinical evidence of renal toxicity. Two infants died of causes unrelated to disseminated candidiasis. Disseminated candidiasis in premature infants was treated successfully with 0.5 mg/kg doses of Amp-B, but further studies with more evaluable cases are needed to confirm the correct dose.
authors.affiliation: Department of Pediatrics, State University of New York, Stony Brook.
authors.forename: J E
authors.initials: JE
authors.lastname: Hall
authors.forename: F
authors.initials: F
authors.lastname: Cox
authors.forename: K
authors.initials: K
authors.lastname: Karlson
authors.forename: A
authors.initials: A
authors.lastname: Robertson
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D003428:Cross Infection / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D008826:Microbial Sensitivity Tests
chemical_list: D000666:Amphotericin B