[Molecular and cellular mechanisms of the induction of differentiation of tumor cells].
Recent data on the mechanism of animal and human tumour cell differentiation induced by different natural and synthetic agents, including antitumour drugs are reviewed. The central role of plasma membranes of the tumour cells and their receptor patterns in the commitment and terminal differentiation of cells is emphasized. Development of a new approach to the cancer therapy based on the combination of tumour cell differentiation induction and cytotoxic effects is discussed.
Belousova
A K
AK
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D006133:Growth Substances; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000473:pathology
D000970:Antineoplastic Agents; D006133:Growth Substances
Molekuliarnye i kletochnye mekhanizmy induktsii differentsirovki opukholevykh kletok.