title: Preoperative radiation and chemotherapy for localized squamous cell carcinoma of the esophagus: a RTOG Study.
abstract: Forty-one evaluable patients with localized squamous cell carcinoma of the thoracic esophagus were treated by a course of radiation therapy (3000 cGy in 3 weeks), 5-Fluorouracil (5-FU) and Cis-platinum (Pt). This was followed by an esophagectomy in medically eligible patients who agreed to the procedure and who had no evidence of extrathoracic tumor. If tumor was found in the specimen, an added 2000 cGy of radiation therapy and additional 5-FU and Pt were given. One-year survival was 44%, 2-year survival 15%, and 3-year survival 8%. All 3-year survivors had tumor-free specimens, but one patient with tumor in the thorax and subdiaphragmatic metastasis survived 2 years.
authors.affiliation: Department of Therapeutic Radiology, Henry Ford Hospital, Detroit, MI 48202.
authors.forename: H G
authors.initials: HG
authors.lastname: Seydel
authors.forename: L
authors.initials: L
authors.lastname: Leichman
authors.forename: R
authors.initials: R
authors.lastname: Byhardt
authors.forename: J
authors.initials: J
authors.lastname: Cooper
authors.forename: A
authors.initials: A
authors.lastname: Herskovic
authors.forename: J
authors.initials: J
authors.lastname: Libnock
authors.forename: R
authors.initials: R
authors.lastname: Pazdur
authors.forename: J
authors.initials: J
authors.lastname: Speyer
authors.forename: J
authors.initials: J
authors.lastname: Tschan
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002945:Cisplatin; D005472:Fluorouracil