Daily variations in the formation of gastric ulcers caused by cervical cord transection in the rat.
Cervical spinal cord transection is used as a model of mammalian stress ulcerogenesis. Circadian variations in gastric ulceration have been demonstrated in other animal models. We investigated whether gastric ulceration changed after cervical cord transection throughout a 24-h period by subjecting different groups of rats to cord transection. Ulcers were quantitated using an index described by Szabo and colleagues. Ulcer formation showed significant variation as a function of time of lesioning, with least severe ulceration at 8 AM. We found that cord transection, like other models of gastric ulceration, is also influenced by the circadian system.
Waldrop
R D
RD
Department of Surgery, University of Texas Medical Branch, Galveston.
Rubin
N H
NH
MacLellan
D G
DG
Rayford
P L
PL
Thompson
J C
JC
D000818:Animals; D002940:Circadian Rhythm; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000502:physiology*; D013276:Stomach Ulcer / Q000209:etiology*; D013312:Stress, Physiological / Q000150:complications*