title: Continuous arteriovenous hemodiafiltration: an aggressive approach to the management of acute renal failure.
abstract: Continuous arteriovenous hemodiafiltration (CAVHD) offers a modified therapeutic approach to the patient with acute renal failure. The system employs a hollow-fiber dialyzer, whose perfusion is dependent on the patient's BP. Peritoneal dialysis solution is infused through the dialysate ports in a direction countercurrent to blood flow at a rate of 500 to 1,500 mL/h. Five complex patients with acute renal failure were treated with CAVHD for periods ranging from two to 40 days. Urea clearances approached 37 L/d, and in stable patients, the BUN was maintained at 40 to 60 mg/dL and serum creatinine 1.4 to 4.0 mg/dL. Ultrafiltration up to 1 L/h could be obtained without difficulty. CAVHD is a safe and technically simple procedure that is particularly suitable for hemodynamically unstable patients with ongoing needs for fluid removal.
authors.affiliation: Department of Internal Medicine, University of Arizona, Tucson.
authors.forename: M E
authors.initials: ME
authors.lastname: Pattison
authors.forename: S M
authors.initials: SM
authors.lastname: Lee
authors.forename: D A
authors.initials: DA
authors.lastname: Ogden
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D001794:Blood Pressure; D001806:Blood Urea Nitrogen; D006440:Hemofiltration; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D013997:Time Factors
chemical_list: D006493:Heparin