title: Effects of chronic diphenylhydantoin on cerebral metabolism in the adult rat.
abstract: Diphenylhydantoin is one of the most widely used anticonvulsant agents in humans. To examine its effects on brain metabolism, we used the quantitative autoradiographic [14C]deoxyglucose method to measure local cerebral glucose utilization in adult rats receiving 50 mg/kg/day diphenylhydantoin for 1 week. Thirty-three brain structures were analyzed to determine whether the drug has global or site-specific effects on cerebral metabolism. Chronic administration produced statistically significant decreases in 23 neocortical and subcortical structures compared with those in vehicle-injected control animals. Therefore, our data support the concept that diphenylhydantoin has widespread depressant effects on brain metabolism.
authors.affiliation: Department of Neurosurgery, State University of New York Health Sciences Center, Brooklyn 11203.
authors.forename: J W
authors.initials: JW
authors.lastname: Melisi
authors.forename: D L
authors.initials: DL
authors.lastname: Dow-Edwards
authors.forename: M K
authors.initials: MK
authors.lastname: Hammock
authors.forename: T H
authors.initials: TH
authors.lastname: Milhorat
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010672:Phenytoin