Porcine focal symmetrical poliomyelomalacia: experimental reproduction with oral doses of encapsulated sodium selenite.
Sodium selenite (encapsulated as doses of 1.4 mg, 2.6 mg and 4.2 mg per kilogram of body weight) was given orally on a daily basis to male weaner pigs, and features of these animals were compared to a control group. Porcine focal symmetrical poliomyelomalacia was produced in all experimental groups between 3 and 20 days after initiation of the treatment. Analysis of blood and several tissues revealed an elevated selenium content for all pigs. Histological lesions in the brain and the cervical lumbar/sacral spinal cord enlargements included endothelial proliferation, neuronal degeneration, microcavitation and glial cell reaction.
Wilson
T M
TM
Department of Veterinary Science, Pennsylvania State University, University Park 16802.
Hammerstedt
R H
RH
Palmer
I S
IS
deLahunta
A
A
D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000473:pathology; D008297:Male; D009525:Niacin / Q000032:analysis; D020887:Selenious Acid; D012643:Selenium / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis; D013116:Spinal Cord / Q000473:pathology; D013118:Spinal Cord Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced* / Q000473:pathology
D009525:Niacin; D020887:Selenious Acid; D012643:Selenium