Immune-mediated glomerulonephritis after exposure to paraquat.
Exposure to paraquat was followed 1 week later by mild respiratory distress in a previously healthy farmer who developed a mixed nephrotic/nephritic syndrome 3 months later. Percutaneous renal biopsy showed endo-extra-capillary proliferative glomerulonephritis associated with a linear pattern of IgG deposits along the glomerular capillary wall. This is the first case report of an association between exposure to a low dose of paraquat (as suggested by the mildness of the respiratory symptoms) and development of glomerulonephritis, possibly related to the occurrence of anti-glomerular basement membrane antibodies. The possibility is suggested that immune-mediated mechanisms of glomerular damage may be triggered by exposure to low-dose paraquat.
Stratta
P
P
Cattedra di Nefrologia, Università di Torino, Italia.
Mazzucco
G
G
Griva
S
S
Tetta
C
C
Monga
G
G
D000293:Adolescent; D001485:Basement Membrane / Q000276:immunology / Q000648:ultrastructure; D003176:Complement C3 / Q000032:analysis; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology / Q000648:ultrastructure; D010269:Paraquat / Q000009:adverse effects*
D003176:Complement C3; D007074:Immunoglobulin G; D010269:Paraquat