title: Single doses of ofloxacin in uncomplicated gonorrhoea.
abstract: The clinical efficacies of 2 different single-dose oral treatments of ofloxacin were evaluated in a double-blind, randomised study of 60 males with gonococcal urethritis. 30 patients received a single dose of ofloxacin 100mg and 30 received a single dose of ofloxacin 200mg. The minimal inhibitory concentrations of ofloxacin against all isolates were less than or equal to 0.25 mg/L. Neisseria gonorrhoeae was eradicated from all 50 patients evaluated and clinical cure was achieved in 84%. In total, 8 patients developed post-gonococcal urethritis, although there was a significantly (p less than 0.05) lower rate of post-gonococcal urethritis in the group treated with ofloxacin 200mg. In conclusion, a single oral dose of ofloxacin 100mg could be an alternative treatment for uncomplicated gonorrhoea.
authors.affiliation: Department of Microbiology, STD Clinic, University of Seville, School of Medicine.
authors.forename: J
authors.initials: J
authors.lastname: Aznar
authors.forename: R
authors.initials: R
authors.lastname: Prados
authors.forename: A
authors.initials: A
authors.lastname: Herrera
authors.forename: A
authors.initials: A
authors.lastname: Rodriguez-Pichardo
authors.forename: E J
authors.initials: EJ
authors.lastname: Perea
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006069:Gonorrhea / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin; D010078:Oxazines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011897:Random Allocation; D014526:Urethritis / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin