Use of phenolic glycolipid 1 for serodiagnosis of leprosy in a high prevalence village in Papua New Guinea.
This study reports on the usefulness of an IgM phenolic glycolipid 1 (PGL-1) ELISA for serodiagnosis of leprosy in the first year of a prospective longitudinal community survey in a high (8.8%) prevalence village in Papua New Guinea. The IgM PGL-1 ELISA had limited value as a screening method for detection of new cases. Many normal persons, particularly children, had elevated IgM anti-PGL-1 antibodies, presumably a consequence of early subclinical infection.
Baumgart
K
K
Clinical Immunology Research Centre, University of Sydney, Australia.
Britton
W
W
Basten
A
A
Bagshawe
A
A
D000942:Antigens, Bacterial; D004797:Enzyme-Linked Immunosorbent Assay; D006017:Glycolipids; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007918:Leprosy / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D008137:Longitudinal Studies; D009166:Mycobacterium leprae; D010219:Papua New Guinea; D011446:Prospective Studies; D012424:Rural Population
D000942:Antigens, Bacterial; D006017:Glycolipids; D007075:Immunoglobulin M; C045169:phenolic glycolipid I, Mycobacterium leprae