Pharmacokinetics of veralipride after chronic administration in humans.
A pharmacokinetic study of veralipride (N-[(1-allyl-2-pyrroli dinyl)methyl]-5-sulfamoyl-o-veratramide) was performed in healthy volunteers during a chronic administration. The pharmacokinetic model based on the hypothesis of a double site for drug absorption, previously used after a single-dose oral administration, was developed to fit the data obtained after chronic administration. The empirical model used allows correct depiction of the behavior of the drug in the body, especially secondary peaks. According to the results, veralipride pharmacokinetics did not show any change upon chronic administration.
Staveris
S
S
Laboratoire de Pharmacie Chimique, Faculté de Pharmacie, Strasbourg, France.
Plusquellec
Y
Y
Campistron
G
G
Barre
J
J
Rochas
M A
MA
Jung
L
L
Tillement
J P
JP
Koffell
J C
JC
Houin
G
G
D000328:Adult; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008875:Middle Aged; D008954:Models, Biological; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D013469:Sulpiride; C027429:veralipride