Lack of cross-reaction in antibody-dependent cellular cytotoxicity between human immunodeficiency virus (HIV) and HIV-related West African strains.
Sera from individuals infected with human immunodeficiency virus (HIV) and HIV-related West African viruses can mediate high-titered, virus-specific antibody-dependent cellular cytotoxicity (ADCC) in all stages of infection. No cross-reactive ADCC can be detected between HIV and HIV-related West African strains LAV-2, HTLV-IV, and SBL-6669. Because these two groups of viruses have antigenically distinct envelope glycoproteins, ADCC-mediating antibodies are most likely directed against envelope antigens. For HIV-specific ADCC, this was further confirmed by using sera reacting with HIV envelope but negative for antibodies against viral core antigens.
Ljunggren
K
K
Department of Immunology, Karolinska Institute, Stockholm, Sweden.
Chiodi
F
F
Biberfeld
G
G
Norrby
E
E
Jondal
M
M
Fenyö
E M
EM
D000354:Africa, Western; D000914:Antibodies, Viral / Q000302:isolation & purification / Q000502:physiology; D000920:Antibody-Dependent Cell Cytotoxicity; D000956:Antigens, Viral / Q000276:immunology; D003429:Cross Reactions; D006678:HIV / Q000276:immunology*; D006801:Humans; D013045:Species Specificity
D000914:Antibodies, Viral; D000956:Antigens, Viral