Update and future perspectives of a thymic biological response modifier (Thymomodulin).
Thymomodulin (Ellem Industria Farmaceutica spa, Milan, Italy) is a calf thymus acid lysate with immunomodulating activities. It is composed of several peptides with a molecular weight range of 1-10kD. Extensive studies in animal systems showed that Thymomodulin exhibited no, or very little toxicity even when used at high doses. Studies done in vitro and in vivo demonstrated that Thymomodulin is a biologically active compound which regulates the maturation of human and murine pre T lymphocytes, as well as modulate the functions of apparently mature human and animal B and T lymphocytes. It was observed that Thymomodulin can promote myelopoiesis as demonstrated by an increase of granulocyte-macrophage colonies in agar. Although additional studies to examine its target cell lineage are required, it appears that Thymomodulin exhibits specificity toward T cells. Therefore, enhancement of other cell lineage functions by Thymomodulin may be indirect, and mainly due to its effect on T cells. Of major importance is to note that Thymomodulin is prepared in a manner which allows it to maintain its biological activity when administered orally.
Cazzola
P
P
Ellem Industria Farmaceutica s.p.a., Milan, Italy.
Mazzanti
P
P
Kouttab
N M
NM
D000163:Acquired Immunodeficiency Syndrome / Q000628:therapy*; D000276:Adjuvants, Immunologic; D000368:Aged; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002417:Cattle; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006509:Hepatitis B / Q000628:therapy*; D006801:Humans; D006967:Hypersensitivity; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D011919:Rats, Inbred Strains; D013949:Thymus Extracts / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D013950:Thymus Gland / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000596:Amino Acids; D009153:Mutagens; D013949:Thymus Extracts; C051006:thymomodulin