title: Effect of cholecystectomy on mouth-to-cecum transit of a liquid meal.
abstract: Mouth-to-cecum transit and serum bile acid profile after ingestion of a lactulose-labeled liquid meal (440 kcal) were measured in eight patients with gallstones and a radiologically functioning gallbladder before and three to five months after cholecystectomy and in 15 controls. In the patients mouth-to-cecum transit was longer after the operation, 87.5 +/- 18.5 (mean +/- SEM) min vs 57.5 +/- 9.7 min (P less than 0.05). Mouth-to-cecum transit times before and after the operation were not different from controls (58.0 +/- 6.7 min). Serum bile acid AUCs were similar (P = NS) in patients and controls, while total bile acid and cholylglycine fasting concentrations were higher after cholecystectomy (P less than 0.05 and P less than 0.01 respectively). Cholecystectomy prolongs mouth-to-cecum transit of a liquid meal.
authors.affiliation: Department of Gastroenterology and Nutrition, Central Middlesex Hospital, London, England.
authors.forename: R
authors.initials: R
authors.lastname: Penagini
authors.forename: R C
authors.initials: RC
authors.lastname: Spiller
authors.forename: J J
authors.initials: JJ
authors.lastname: Misiewicz
authors.forename: P G
authors.initials: PG
authors.lastname: Frost
authors.forename: D B
authors.initials: DB
authors.lastname: Silk
mesh_terms: D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000097:blood; D001944:Breath Tests; D002432:Cecum; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005526:Food, Formulated; D005769:Gastrointestinal Motility; D006000:Glycocholic Acid / Q000097:blood; D006801:Humans; D006859:Hydrogen / Q000032:analysis; D008875:Middle Aged; D009055:Mouth; D013997:Time Factors
chemical_list: D001647:Bile Acids and Salts; D006859:Hydrogen; D006000:Glycocholic Acid