Early effects of oestrogen treatment on lipogenesis de novo and on biosynthesis of triacylglycerol from fatty acids in male chick liver.
1. Early changes (0-44 hr) in liver and plasma lipid levels and in the rate of hepatic lipogenesis were measured in male chicks after a single intramuscular injection of oestradiol-17 beta. 2. Chick liver slices were employed to measure the rate of lipogenesis de novo using 3H2O and the rate of triacylglycerol synthesis from [9, 10-3H] palmitate at various times after injection. 3. The results suggest that oestrogen-induced lipogenesis occurs initially by a rapid and coordinated stimulation of the total hepatic capacity for lipogenesis de novo and for triacyglycerol synthesis from fatty acids. 4. The results are discussed in relation to oestrogen-induced changes in hepatic lipogenic enzymes.
Courtney
S
S
Department of Zoology, University of Durham, U.K.
Talbot
S
S
Manning
R
R
D000818:Animals; D002645:Chickens; D004247:DNA / Q000032:analysis; D004958:Estradiol / Q000494:pharmacology*; D007700:Kinetics; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism*; D014280:Triglycerides / Q000096:biosynthesis*; D014316:Tritium
D008055:Lipids; D010169:Palmitic Acids; D014280:Triglycerides; D014316:Tritium; D019308:Palmitic Acid; D004958:Estradiol; D004247:DNA