Age-dependent differences in cholinergic drug response in two strains of mice.
The behavioral effects of nicotine and oxotremorine were assessed in two strains of mice, C57BL/6 (C57) and DBA/2 (DBA), differing in the ontogeny of forebrain cholinergic structures. Both nicotine and oxotremorine depressed to a higher extent the behavior of DBA mice starting at day 45 of postnatal life.
Castellano
C
C
Istituto di Psicobiologia e Psicofarmacologia del CNR, Rome, Italy.
Oliverio
A
A
Schwab
C
C
Brueckner
G
G
Biesold
D
D
D000375:Aging; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000254:growth & development* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009043:Motor Activity / Q000187:drug effects*; D009538:Nicotine / Q000494:pharmacology*; D010095:Oxotremorine / Q000494:pharmacology*; D013045:Species Specificity
D010095:Oxotremorine; D009538:Nicotine