Heterogeneity of biotransformation of fluoranthene in perifused liver cells.
Pathways of biotransformation of the carcinogenic polycyclic hydrocarbon fluoranthene in individual isolated perifused liver cells were delineated using noninvasive microfluorescence spectroscopic techniques. An example of heterogeneity of coupling between phase I and phase II enzymes detected in a population of beta-naphthoflavone-induced rat liver cells demonstrates the usefulness of the experimental model of perifused liver cells.
Stier
A
A
Max-Planck-Institut for Biophysical Chemistry, Göttingen, Federal Republic of Germany.
Schlenker
A
A
Sidhu
J
J
Kühnle
W
W
Finch
S A
SA
D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D005449:Fluorenes / Q000378:metabolism* / Q000493:pharmacokinetics; D005453:Fluorescence; D008099:Liver / Q000378:metabolism*; D008297:Male; D010636:Phenols / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D005449:Fluorenes; D010636:Phenols; C007738:fluoranthene; D003577:Cytochrome P-450 Enzyme System