Chromosome 5 allele loss at the glucocorticoid receptor locus in human colorectal carcinomas.
Matched normal/tumor DNA pairs from sporadic colon carcinoma patients were examined for chromosome 5 allele loss using a probe for a functional gene (glucocorticoid receptor = GRL) locus. This locus maps (5q11-q13) close to one of two alternative sites recently reported for a constitutional deletion in a familial adenomatous polyposis (FAP) patient. Tumor-specific allele loss of at least 27% at GRL supports the hypothesis that both hereditary and sporadic forms of colon cancer result from mutations of the same gene. The proximity of the GRL locus to the region of 5q affected in FAP and the observed tumor-specific allele loss at this locus suggest that further research is needed regarding whether genetic alterations in the glucocorticoid receptor may be associated with colon carcinogenesis.
Wildrick
D M
DM
University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Section of Gastrointestinal Oncology and Digestive Diseases 77030.
Boman
B M
BM
D000230:Adenocarcinoma / Q000235:genetics* / Q000378:metabolism; D000483:Alleles; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5; D003110:Colonic Neoplasms / Q000235:genetics* / Q000378:metabolism; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D009693:Nucleic Acid Hybridization; D011965:Receptors, Glucocorticoid / Q000235:genetics*; D012004:Rectal Neoplasms / Q000235:genetics* / Q000378:metabolism
D004273:DNA, Neoplasm; D011965:Receptors, Glucocorticoid