title: Bancroftian filariasis in coastal north Trinidad: the effects of mass chemotherapy using spaced doses of diethylcarbamazine citrate on human microfilaraemias and vector infection rates.
abstract: The effects of a mass chemotherapy programme using spaced doses of diethylcarbamazine citrate on Wuchereria bancrofti microfilaraemias and vector infection rates were studied in an isolated rural community of 650 people in north Trinidad where a microfilaria rate of 15% had previously been recorded. A single oral dose of 6 mg/kg body weight was given at monthly intervals for one year. After 6 months, 79% (52/66) of persons previously microfilaraemic had become negative. After 12 months the negative proportion had increased to 90% (63/70). The geometric mean microfilaria density of those still microfilaraemic was reduced from 19.7 to 4.6 per 100 mm3 of blood. Of 147 initially negative persons, none had become positive following treatment. Filarial infection rates in Culex quinquefasciatus from randomly sampled houses fell from 6.4% to zero; in houses where occupants with microfilaraemia had been identified before treatment, the rate was reduced from 15.8% to zero. In a supplementary study, however, weekly collections from one initially positive house showed a rapid decline in the vector infection rate from 43% to 2% after three months but an additional 3 months elapsed before the index reached zero. There was negligible microfilarial uptake by the vectors from residual low-density microfilaraemias (less than 10 microfilariae per 100 mm3 of blood) after chemotherapy.
authors.affiliation: PAHO/WHO Caribbean Epidemiology Centre, Port-of-Spain, Trinidad, West Indies.
authors.forename: M B
authors.initials: MB
authors.lastname: Nathan
authors.forename: P J
authors.initials: PJ
authors.lastname: Hamilton
authors.forename: S
authors.initials: S
authors.lastname: Monteil
authors.forename: E S
authors.initials: ES
authors.lastname: Tikasingh
mesh_terms: D000818:Animals; D003465:Culex / Q000469:parasitology; D004049:Diethylcarbamazine / Q000008:administration & dosage* / Q000627:therapeutic use; D004605:Elephantiasis, Filarial / Q000188:drug therapy*; D005368:Filariasis / Q000188:drug therapy*; D006801:Humans; D007300:Insect Control; D007303:Insect Vectors; D008842:Microfilariae / Q000302:isolation & purification; D014300:Trinidad and Tobago; D014958:Wuchereria bancrofti / Q000302:isolation & purification
chemical_list: D004049:Diethylcarbamazine