Androgen receptors in meningiomas.
Meningiomas have been hypothesized as being hormonally sensitive on the basis of epidemiologic, clinical, and laboratory evidence. Eight meningiomas were assayed and found to have androgen-binding protein. Three tumors were subjected to in vitro growth studies in varying concentrations of dihydrotestosterone (DHT). The growth of tumor 1 was unaltered. Tumor 2 demonstrated 9% to 10% growth (P less than 0.05) in all concentrations tested. Tumor 3 revealed an 11% stimulation, but only in the lowest concentration of DHT tested. The small quantity, saturability, and in one tumor, high binding affinity, suggest this binding protein is a receptor. The in vitro response of these meningiomas was small and was not dose-related or proportionate to receptor quantity. Androgens do not appear to play as important a role as progesterone or estrogen in meningioma growth in vitro.
Olson
J J
JJ
Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City 52242.
Beck
D W
DW
MacIndoe
J W
JW
Min-Loh
P
P
D000328:Adult; D000368:Aged; D013196:Dihydrotestosterone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000032:analysis* / Q000188:drug therapy; D008579:Meningioma / Q000032:analysis* / Q000188:drug therapy; D008875:Middle Aged; D011944:Receptors, Androgen / Q000032:analysis*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D011944:Receptors, Androgen; D013196:Dihydrotestosterone