Cholecystokinin antagonists. Synthesis and biological evaluation of 3-substituted 1,4-benzodiazepin-2-amines.
Bock
M G
MG
Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486.
DiPardo
R M
RM
Evans
B E
BE
Rittle
K E
KE
Freidinger
R M
RM
Chang
R S
RS
Lotti
V J
VJ
D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D002540:Cerebral Cortex / Q000378:metabolism; D002766:Cholecystokinin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006168:Guinea Pigs; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D011949:Receptors, Cholecystokinin / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship
D000588:Amines; D007202:Indicators and Reagents; D011949:Receptors, Cholecystokinin; D001569:Benzodiazepines; D002766:Cholecystokinin