title: Radionuclide exploration of dialysis amyloidosis: preliminary experience.
abstract: The noninvasive diagnosis of amyloid arthropathy in dialysis patients is still uncertain. Therefore, we investigated the potential diagnostic value of the 99mTc-methylene diphosphonate scan in seven long-term hemodialysis patients suffering from chronic joint pain who had biopsy-proven osteoarticular amyloidosis of the recently discovered beta 2-microglobulin (beta 2-M) type. In six, but in none of five control patients on short-term hemodialysis, increased tracer uptake was found at the site of one or several articular and/or periarticular regions. Increased uptake at a given joint was often, but not always, associated with joint pain. It appeared to precede radiologically visible changes. In conclusion, the 99mTc-methylene diphosphonate scan may be of help in the early diagnosis of dialysis amyloidosis.
authors.affiliation: Départment de Néphrologie, Hôpital Necker, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Grateau
authors.forename: J
authors.initials: J
authors.lastname: Zingraff
authors.forename: M
authors.initials: M
authors.lastname: Fauchet
authors.forename: O
authors.initials: O
authors.lastname: Mundler
authors.forename: P
authors.initials: P
authors.lastname: Raymond
authors.forename: J M
authors.initials: JM
authors.lastname: Berthelot
authors.forename: T
authors.initials: T
authors.lastname: Bardin
authors.forename: D
authors.initials: D
authors.lastname: Kuntz
authors.forename: T
authors.initials: T
authors.lastname: Drüeke
mesh_terms: D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000209:etiology; D001175:Arthrography; D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D001842:Bone and Bones / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D007596:Joints / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D006435:Renal Dialysis / Q000009:adverse effects*