title: [Concept of treatment of metastatic breast cancer outside university clinics: description of the method and evaluation of efficacy].
abstract: It has been recognized during the past decade that it may be advantageous to develop complex strategies for treatment of metastatic breast cancer (MBC). In these strategies the type and efficacy of preceding therapies and the compliance of the patients have to be considered. Since about 80% of all patients with MBC are treated outside university hospitals it should be tested if a complex strategy for treatment of MBC can be realized in these institutions. The method was based on three principles: There was an exchange of data between participating institutions and study center after each visit of a patient. Second, there was one data sheet for admission of a patient to the study and fifteen sheets for follow-up documentation each with a different bottom line; in the bottom line of these sheets two therapies according to the strategy were proposed, one in case of 'no progression' and another in case of 'progression' of the disease. Third, a copy of completed sheets had to be returned to the study center; the study center provided the next sheet with the appropriate treatment recommendation. 335 evaluable patients were prospectively recruited from 27 participating institutions between January 1983 and December 1985. Based on the estimated incidence of MBC in the region, it was calculated that 45% of all MBC patients of the region had been admitted to the study. Only 27% of these patients were treated at the university hospital indicating that 85% of all MBC patients of the region were treated outside university hospitals.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Regionale Studiengruppe: Tumorzentrum Ulm.
authors.forename: F
authors.initials: F
authors.lastname: Porzsolt
authors.forename: W
authors.initials: W
authors.lastname: Schreml
authors.forename: L
authors.initials: L
authors.lastname: Buchelt
authors.forename: G
authors.initials: G
authors.lastname: Meuret
authors.forename: S
authors.initials: S
authors.lastname: Mende
authors.forename: P
authors.initials: P
authors.lastname: Strigl
authors.forename: M
authors.initials: M
authors.lastname: Redenbacher
authors.forename: D
authors.initials: D
authors.lastname: Klumpp
authors.forename: M
authors.initials: M
authors.lastname: Schmelz
authors.forename: R
authors.initials: R
authors.lastname: Knöchelmann
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D002173:Cancer Care Facilities; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D009362:Neoplasm Metastasis
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate
vernacular_title: Konzept zur Behandlung metastasierender Mammakarzinome ausserhalb von Universitätskliniken: Beschreibung der Methode und Prüfung der Effizienz.