[Antagonism of caerulein, a CCK-8 receptor agonist, to the behavioral effects of ketamine in mice and rats].
It has been established in experiments on male mice and rats that caerulein antagonized the behavioural effects of ketamine, an agonist of phencyclidine receptors. Caerulein (75-375 micrograms/kg) and haloperidol (0.1-1.5 mg/kg) suppressed the stereotyped behaviour and motor excitation induced by ketamine (30 mg/kg) in mice. Caerulein and haloperidol failed to affect ketamine-induced ataxia. Caerulein (10 micrograms/kg) and the opioid antagonist naloxone (5 mg/kg) completely blocked the amnestic action of ketamine (30 mg/kg) in passive avoidance experiments on rats. It seems likely that the suppression of the behavioural effects of ketamine by caerulein is related to its functional antagonism with dopamine and opioid receptors.
Vasar
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Allikmets
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LKh
Soosaar
A Kh
AKh
D000647:Amnesia / Q000517:prevention & control; D000818:Animals; D001259:Ataxia / Q000517:prevention & control; D001522:Behavior, Animal / Q000187:drug effects*; D002108:Ceruletide / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D007649:Ketamine / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011949:Receptors, Cholecystokinin / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects
D011949:Receptors, Cholecystokinin; D009270:Naloxone; D007649:Ketamine; D002108:Ceruletide; D006220:Haloperidol
Antagonizm tseruleina, agonista KhTsK-8 retseptorov k povedencheskim éffektam ketamina u mysheĭ i krys.