Measurements of oxygen pressure in the vocal fold during laryngeal nerve stimulation.
To clarify the mechanisms of ischemic change in the vocal fold on phonation, model experiments were performed under various conditions by recording tissue oxygen pressure (Pto2) values under electrical stimulation of either the recurrent laryngeal nerves or external branches of the superior laryngeal nerves. In addition, autonomic nerve regulation of laryngeal vessels was estimated under administration of succinylcholine chloride. Oxygen pressures of the vocal fold were measured in the lamina propria and vocal muscle at the middle of the membranous portion. The Pto2 in the lamina propria showed a slight increase during lower-frequency stimulation and a slight decrease during higher-frequency stimulation of the recurrent laryngeal nerve. The Pto2 in the vocal muscle showed a decrease during stimulation of the recurrent laryngeal nerve. On the other hand, the Pto2 showed almost no change in the lamina propria or vocal muscle during stimulation of the external branch of the superior laryngeal nerve. It is supposed that an ischemic change in the vocal muscle on phonation results mainly from contraction of the vocal muscle. On the contrary, the ischemic change in the vocal mucosa on phonation does not appear to be directly caused by the contraction of the vocal muscle but by other factors, such as wavelike movement.
Tomita
M
M
Department of Otolaryngology, Saga Medical School, Japan.
Matsuo
K
K
Maehara
N
N
Umezaki
T
T
Shin
T
T
D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D007823:Laryngeal Nerves / Q000187:drug effects / Q000502:physiology*; D009119:Muscle Contraction; D010100:Oxygen / Q000378:metabolism*; D011312:Pressure; D012009:Recurrent Laryngeal Nerve / Q000187:drug effects / Q000502:physiology; D013390:Succinylcholine / Q000494:pharmacology; D014827:Vocal Cords / Q000098:blood supply / Q000378:metabolism*
D013390:Succinylcholine; D010100:Oxygen