title: Urinary C-peptide in the neonate correlates both to maternal glucose tolerance and to fetal size at birth.
abstract: In 18 women with gestational diabetes the variables of an oral glucose tolerance test (fasting and 2-hour blood glucose values and area under the blood glucose curve) performed in the last trimester of pregnancy correlated significantly with the urinary C-peptide excretion during the first 12 hours of the life (r = 0.47, 0.71, and 0.60, respectively). In a combined group with 28 type II pregnant diabetic women there was also a significant correlation between the urinary C-peptide excretion of the infants and their skinfold. Assay of the urinary C-peptide excretion of the neonate, reflecting its insulin production, seems to be a sensitive parameter to study the influence of the maternal carbohydrate metabolism in the offspring.
authors.affiliation: Department of Obstetrics and Gynecology, Huddinge University Hospital, Sweden.
authors.forename: N O
authors.initials: NO
authors.lastname: Lunell
authors.forename: B
authors.initials: B
authors.lastname: Persson
authors.forename: L V
authors.initials: LV
authors.lastname: Devarajan
authors.forename: S
authors.initials: S
authors.lastname: Hassan
authors.forename: H
authors.initials: H
authors.lastname: Hathout
authors.forename: R
authors.initials: R
authors.lastname: Kasrawi
authors.forename: A
authors.initials: A
authors.lastname: Saleh
authors.forename: L
authors.initials: L
authors.lastname: Viktorin
mesh_terms: D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis*; D001827:Body Height; D002096:C-Peptide / Q000652:urine*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007231:Infant, Newborn / Q000652:urine*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*; D012189:Retrospective Studies; D012885:Skinfold Thickness
chemical_list: D001786:Blood Glucose; D002096:C-Peptide