Radiation induced heart disease in hypertensive rats.
Spontaneously hypertensive Wistar rats were given single doses of X rays to their heart. Irradiation decreased the blood pressure before any myocardial radiation damage was apparent. Male rats, which were more hypertensive than female rats, had a shorter survival time after local heart irradiation than female rats. Antihypertensive treatment with hydralazine did not increase the survival time. It is considered that myocardial hypertrophy is the cause of the increased susceptibility of spontaneously hypertensive rats to local heart irradiation.
Lauk
S
S
Institut fur Strahlenbiologie der GSF, Neuherberg, Germany.
Trott
K R
KR
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006321:Heart / Q000502:physiology / Q000503:physiopathology / Q000528:radiation effects*; D006331:Heart Diseases / Q000209:etiology* / Q000503:physiopathology; D006830:Hydralazine / Q000494:pharmacology; D009206:Myocardium / Q000473:pathology; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*
D006830:Hydralazine