[Suppressive effect of the blast cells of AKR strain mice on antibody formation in vivo and lymphocyte proliferation in vitro].
Blast cells obtained from the "erythropoietic spleen" of FG-stimulated young mice and cells accumulating in the spleens of preleukemic AKR mice have a marked suppressive effect on spontaneous and mitogen-induced proliferation of young mouse splenocytes in vitro and suppress the development of humoral immune response in immunized recipients during syngeneic transfer in vivo. Some disturbances in erythron system in preleukemic AKR mice manifested in the accumulation of immature erythroid precursors which are suppressors of immunocompetent lymphocytes are suggested to be a pathogenetic link in the development of leukemia.
Kashlakova
N V
NV
Lisukov
I A
IA
Tsyrlova
I G
IG
Vasil'ev
N V
NV
Kozlov
V A
VA
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004920:Erythropoiesis; D007108:Immune Tolerance / Q000187:drug effects; D007114:Immunization; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008806:Mice, Inbred AKR / Q000276:immunology*; D010659:Phenylhydrazines / Q000494:pharmacology; D011289:Preleukemia / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology
D010659:Phenylhydrazines; C030299:phenylhydrazine
Supressivnyĭ éffekt blastnykh kletok mysheĭ linii AKR na antiteloobrazovanie in vivo i proliferatsiiu limfotsitov in vitro.