Open-field behavior of one-clip, two-kidney hypertensive rats: the influence of pre-handling.
The relation between the development of hypertension and changes in behavior was investigated. Hypertension was induced by unilateral application of a 0.20-mm clip around the renal artery. At 4 weeks, but not at 1 week, after the operation an increase in ambulation was found. Blood pressure was significantly increased at 1 (28 mm Hg) and 4 weeks (78 mm Hg) after the operation. In a second experiment, renal hypertensive rats and controls were either regularly handled (i.e., subjected to indirect tail-cuff blood pressure measurements) or left undisturbed. At 4 weeks after clip implantation, only in the nonhandled rats with renal hypertension, an increase in open-field ambulation was found. Blood pressure was markedly increased in both handled and nonhandled renal hypertensive rats.
van den Buuse
M
M
Rudolf Magnus Institute for Pharmacology, University of Utrecht, Medical Faculty, The Netherlands.
de Jong
W
W
D000818:Animals; D001835:Body Weight; D006234:Handling, Psychological; D006977:Hypertension, Renal / Q000503:physiopathology / Q000523:psychology*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors