Sequential development of chronic lymphocytic leukemia in a patient with polycythemia vera.
A patient with a seven-year history of polycythemia vera treated by repeated phlebotomies and intermittent busulfan administration developed gradually lymphocytosis accompanied by thrombocytopenia in peripheral blood and in the bone marrow. A marked pathological monoclonal proliferation of the B-cell population was detected. The sequential development of chronic lymphocytic leukemia in the patient with polycythemia vera could be considered as a coincidence because there is no reliable explanation of this event at present.
Koza
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I
Cancer Research Institute of the Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Babusíková
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O
D000954:Antigens, Surface / Q000032:analysis; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000473:pathology; D008875:Middle Aged; D011087:Polycythemia Vera / Q000150:complications* / Q000473:pathology
D000954:Antigens, Surface