Six complementation groups for ionising-radiation sensitivity in Chinese hamster cells.
The ionising radiation-sensitive mutants irs 1, irs 2, irs 3, xrs-1 (or xrs-7), EM7 and XR-1 were fused to wild-type cells or to each other in pairs to create hybrid cells. These hybrids were checked chromosomally and their X-ray sensitivity tested. Each mutant was found to be recessive to wild-type and to complement the X-ray sensitivity of the other mutants. Thus there appear to be at least 6 complementation groups for ionising radiation sensitivity in Chinese hamster cells.
Jones
N J
NJ
Cell and Molecular Biology Division, MRC Radiobiology Unit, Oxon, Great Britain.
Cox
R
R
Thacker
J
J
D000818:Animals; D002459:Cell Fusion / Q000528:radiation effects; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D003433:Crosses, Genetic; D005808:Genes, Recessive; D005816:Genetic Complementation Test; D006822:Hybrid Cells / Q000528:radiation effects*; D009154:Mutation; D010641:Phenotype; D014965:X-Rays