A mismatch repair-based model can explain some features of u.v. mutagenesis in yeast.
Our studies on the REV2-dependent processes of DNA repair and u.v. mutagenesis in yeast are summarized and compared with the general features of DNA damage-induced mutagenesis in yeast. On the basis of the data available, we propose that mismatch repair is an essential process in u.v. mutagenesis. We assume that a photoproduct site in double-stranded DNA can be handled as a replicative mismatch leading to misinsertion opposite the lesion.
Siede
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Gesellschaft für Strahlen- und Umweltforschung, Institut für Strahlenbiologie, Neuherberg, FRG.
Eckardt-Schupp
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D004260:DNA Repair; D004261:DNA Replication; D004271:DNA, Fungal / Q000528:radiation effects; D005800:Genes, Fungal; D008957:Models, Genetic; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000528:radiation effects; D014466:Ultraviolet Rays
D004271:DNA, Fungal