title: Treatment of advanced and recurrent squamous carcinoma of the uterine cervix with constant intraarterial infusion of cisplatin.
abstract: Twelve patients with primary or locally recurrent squamous carcinoma of the cervix were treated with constant internal iliac artery infusion of cisplatin (CDDP) via a totally implantable chemotherapy pump. Seven previously untreated patients received standard external and interstitial radiotherapy (RT) in conjunction with CDDP infusion. Five patients with isolated pelvic recurrences received CDDP therapy only. The chemotherapy pump was refilled weekly on an outpatient basis. All nine evaluable patients developed unilateral or bilateral lower extremity pain which responded to dosage reduction. No renal or marrow toxicity was seen. Both of the evaluable patients treated for recurrent tumor died 32 and 60 weeks after initiation of treatment. The seven patients treated primarily with RT + CDDP infusion include one who expired with persistent tumor and one with no evidence of disease (NED) after exenteration for a pelvic recurrence at 48 and 85 weeks respectively. The five remaining patients are NED at 12 to 60 weeks. Constant internal iliac artery infusion of CDDP via an implantable chemotherapy pump can be performed with acceptable toxicity. The preliminary results suggest that further study in previously untreated undergoing concurrent radiotherapy is warranted.
authors.affiliation: Department of Obstetrics and Gynecology, University of California Irvine Medical Center, Orange 92668.
authors.forename: M A
authors.initials: MA
authors.lastname: Rettenmaier
authors.forename: M F
authors.initials: MF
authors.lastname: Moran
authors.forename: N F
authors.initials: NF
authors.lastname: Ramsinghani
authors.forename: M
authors.initials: M
authors.lastname: Colman
authors.forename: N A
authors.initials: NA
authors.lastname: Syed
authors.forename: A
authors.initials: A
authors.lastname: Puthawala
authors.forename: F W
authors.initials: FW
authors.lastname: Jansen
authors.forename: P J
authors.initials: PJ
authors.lastname: DiSaia
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D007261:Infusions, Intra-Arterial; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D011838:Radiation-Sensitizing Agents; D011879:Radiotherapy Dosage; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy
chemical_list: D011838:Radiation-Sensitizing Agents; D002945:Cisplatin