title: Study on tissue concentrations of antibiotics: bacampicillin in gingiva and maxillary bones.
abstract: 21 patients, whose age ranged from 17 to 60 years and who had not been previously treated with antibiotics or other drugs, received bacampicillin as a perioperative prophylaxis for minor operations in the oral cavity. Four oral doses of bacampicillin were administered: each dose of 800 mg every 12 h, and the last dose was administered 2 h before surgery. To assess bacampicillin serum concentrations two blood samples were collected from each patient: the first sample was obtained 1 h before surgery and the second one during surgery. Together with the second blood sample, small quantities of gingiva and bone were obtained from each patient to also assess the antibiotic concentrations in these tissues (microbiological method). The results show that bacampicillin reaches high concentrations in both the blood and tissues studied by us, and that a direct correspondence exists between blood and gingival and bone tissue concentrations. Furthermore, it should be noted that no postoperative infections developed in our patients. These results lead to the conclusion that bacampicillin appears to be a suitable drug in the therapy of dental infections.
authors.affiliation: IV Chair of Microbiology, University La Sapienza, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: del Piano
authors.forename: R
authors.initials: R
authors.lastname: Nicosia
authors.forename: R
authors.initials: R
authors.lastname: Sessa
authors.forename: G
authors.initials: G
authors.lastname: Grippaudo
authors.forename: R
authors.initials: R
authors.lastname: Lolli
authors.forename: B
authors.initials: B
authors.lastname: Monaco
mesh_terms: D000293:Adolescent; D000328:Adult; D000667:Ampicillin / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D005260:Female; D005881:Gingiva / Q000378:metabolism*; D006801:Humans; D008297:Male; D008437:Maxilla / Q000378:metabolism*; D008875:Middle Aged; D009055:Mouth / Q000601:surgery; D011292:Premedication
chemical_list: D000667:Ampicillin; C011674:bacampicillin