Inhibitory effect of beta zero-thalassaemia/haemoglobin E erythrocytes on Plasmodium falciparum growth in vitro.
The growth of Plasmodium falciparum in erythrocytes from individuals with beta zero-thalassaemia or haemoglobin (Hb) E, or both, was assessed in vitro. A significant inhibitory effect on the growth of the parasite was found only with erythrocytes from individuals doubly heterozygous for beta zeros-thalassaemia and HbE. The inhibitory effect was particularly marked with erythrocytes from splenectomized beta zeros-thalassaemia/HbE patients. The protective effect was related to HbF, Hb levels and shape abnormalities of the variant erythrocytes.
Yuthavong
Y
Y
Department of Biochemistry, Faculty of Science, Ramathibodi Hospital, Thailand.
Butthep
P
P
Bunyaratvej
A
A
Fucharoen
S
S
D000818:Animals; D004912:Erythrocytes / Q000469:parasitology*; D006446:Hemoglobin E / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D066298:In Vitro Techniques; D010963:Plasmodium falciparum / Q000254:growth & development*; D013789:Thalassemia / Q000097:blood* / Q000235:genetics
D006455:Hemoglobins, Abnormal; D006446:Hemoglobin E