title: Evaluation of a therapeutic concentration of dithranol in the mouse-tail test.
abstract: A study of dithranol ointment in the mouse-tail test showed that 0.2% dithranol ointment induced a granular layer and orthokeratosis in mouse-tail epidermis. This provides further evidence of the value of the mouse-tail test in evaluating anti-psoriatic activity of topical preparations.
authors.affiliation: Institute of Dermatology, United Medical School, London, U.K.
authors.forename: M
authors.initials: M
authors.lastname: Hofbauer
authors.forename: P M
authors.initials: PM
authors.lastname: Dowd
authors.forename: J
authors.initials: J
authors.lastname: Atkinson
authors.forename: M
authors.initials: M
authors.lastname: Whitefield
authors.forename: M W
authors.initials: MW
authors.lastname: Greaves
mesh_terms: D000818:Animals; D000875:Anthralin / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D011565:Psoriasis / Q000139:chemically induced / Q000188:drug therapy; D011897:Random Allocation; D012867:Skin / Q000187:drug effects*
chemical_list: D000875:Anthralin