Effects of serial administration of kainic acid on the developing brain.
The purpose of this study was to determine whether the repeated administration of kainic acid at 24-hr intervals results in pharmacological kindling. Rather than developing an increased intensity of seizures, this method of serial administration of kainic acid resulted in the development of tolerance to its effects.
Holmes
G L
GL
Department of Neurology, Medical College of Georgia, Augusta.
Thompson
J L
JL
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D007274:Injections, Intraperitoneal; D007608:Kainic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology
D007608:Kainic Acid