title: Improvement of oral colonic lavage with supplemental simethicone.
abstract: We have noted that colons of patients prepared for colonoscopy with Golytely, a nonabsorbable electrolyte lavage solution, frequently contain foam which may obscure small mucosal lesions. Therefore, a randomized, blinded controlled trial was performed to determine the prevalence of Golytely-induced foam and the effect of supplemental simethicone in decreasing the prevalence of foam. Foam was present in 32% of colons prepared with Golytely alone but in none of the colons prepared with Golytely supplemented with simethicone. In addition, only 5% of colons prepared with supplemental simethicone had residual stool noted at the time of colonoscopy, a significant improvement over the 39% prevalence of residual stool in colons prepared with Golytely alone. Addition of simethicone to Golytely lavage decreases the prevalence of colonic foam and residual stool.
authors.affiliation: Department of Internal Medicine, Dallas VA Medical Center, Texas 75216.
authors.forename: W A
authors.initials: WA
authors.lastname: Shaver
authors.forename: P
authors.initials: P
authors.lastname: Storms
authors.forename: W L
authors.initials: WL
authors.lastname: Peterson
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003106:Colon; D003113:Colonoscopy; D004311:Double-Blind Method; D004573:Electrolytes / Q000008:administration & dosage*; D005243:Feces; D006801:Humans; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D011897:Random Allocation; D012828:Silicones / Q000008:administration & dosage*; D012841:Simethicone / Q000008:administration & dosage*; D007507:Therapeutic Irrigation
chemical_list: D004573:Electrolytes; C033608:Golytely; D012828:Silicones; D011092:Polyethylene Glycols; D012841:Simethicone