Components of immune function studied with lymphoid tumors.
Lymphoid tumors have proven to be productive models for investigating genetic, biochemical, physiological and developmental mechanisms of lymphoid cells. Lymphoid tumors of a given lineage exhibit a spectrum of phenotypes from clones whose features overlap extensively with their normal counterparts to clones whose features are not obviously represented in normal lymphoid populations. In addition to the phenotypic continuum represented in a library of related tumors, many clones exhibit phenotypic diversity spontaneously or in response to various stimuli. As laboratory technology has advanced many interesting biological features of lymphoid tumors have become amenable to precise analysis. Progress made in understanding the mechanisms that underly the phenotypic diversity and plasticity of lymphoid tumor cells has the dual impact of improving our knowledge of malignant and normal lymphoid cells.
Lynch
R G
RG
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
D001402:B-Lymphocytes / Q000276:immunology; D005786:Gene Expression Regulation; D005803:Genes, Immunoglobulin; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D008223:Lymphoma / Q000276:immunology*; D010641:Phenotype; D010954:Plasmacytoma / Q000276:immunology
D007136:Immunoglobulins