A DNA polymorphism of the apolipoprotein C-III gene in extracoronary atherosclerosis.
1. A genetic polymorphism of apolipoprotein (apo) C-III was studied in 49 Caucasian patients with extracoronary atherosclerosis demonstrated by angiography. 2. Twelve patients (24%) possessed an uncommon allelic variant of the apo A-I/C-III gene cluster compared with two (4%) in 50 healthy controls (P less than 0.01). 3. Of 27 patients with carotid atherosclerosis, 22% had the uncommon genotype (P less than 0.02), and in aorto-femoral atherosclerosis (n = 22) 27% possessed the uncommon variant (P less than 0.01). 4. When normotriglyceridaemic subgroups (n = 32) with arterial disease were studied the difference in genotype frequencies persisted, 22% having the uncommon allele (P less than 0.01), suggesting that such genetic variants have effects independent of circulating levels of plasma lipids.
O'Connor
G
G
Medical Professorial Unit, St Bartholomew's Hospital, London.
Stocks
J
J
Lumley
J
J
Galton
D J
DJ
D000483:Alleles; D053305:Apolipoprotein C-III; D001056:Apolipoproteins C / Q000235:genetics*; D001161:Arteriosclerosis / Q000235:genetics*; D001345:Autoradiography; D004247:DNA / Q000032:analysis*; D005260:Female; D005787:Gene Frequency; D005796:Genes; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D053305:Apolipoprotein C-III; D001056:Apolipoproteins C; D004247:DNA