A novel protein, p19/6.8, specific for cardiac and slow skeletal muscle.
Upon in vitro translation of mRNAs from slow (soleus) muscles of the mouse a hitherto undescribed translation product has been detected that was absent from fast skeletal muscles and was termed p19/6.8 according to its position in 2-dimensional gels. mRNA for p19/6.8 was also found in the ventricle of the heart. p19/6.8 was not detectable by Coomassie blue staining but could be characterised by fractionation of in vivo labelled muscle tissue. It was found to sediment with the particulate fraction at 14,000 x g. The expression of p19/6.8 mRNA appears to be down-regulated in muscles with phasic activity.
Kluxen
F W
FW
Developmental Biology Unit, University of Bielefeld, FRG.
D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D051379:Mice; D008817:Mice, Mutant Strains; D009124:Muscle Proteins / Q000096:biosynthesis*; D009132:Muscles / Q000032:analysis*; D009206:Myocardium / Q000032:analysis*; D009222:Myotonia / Q000378:metabolism*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism*; D051381:Rats
D009124:Muscle Proteins; D012333:RNA, Messenger