title: Atrophy of middle and short stereocilia on outer hair cells of guinea pig cochleas with experimentally induced hydrops.
abstract: Scanning electron microscopy was employed to investigate hair cell morphology at different stages in the development of experimentally induced hydrops in the guinea pig. A particular form of morpho-pathology, never before described, was identified as characteristic of hydropic cochleas. The pathology was characteristically identified as atrophy of the short and middle stereocilia on the outer hair cells while the inner hair cell stereocilia did not have such a pathology. The atrophy was restricted to the upper cochlear turns in remarkable correspondence with the low/middle frequency sensitivity loss and was detected only at the end of the period of fluctuating thresholds. These stereocilia perturbations appear therefore to be linked with the threshold fluctuations and represent the first evidence for a clear correlation between hair cell morphology and physiology in the experimental model of endolymphatic hydrops. Such a morphopathology might also be expected to occur in cochleas of Menière's patients but may have been overlooked in the past because of the discrete nature of the pathology.
authors.affiliation: Laboratoire d'Audiologie Expérimentale, INSERM Unité 229, Université Bordeaux II, Hôpital Pellegrin, France.
authors.forename: K C
authors.initials: KC
authors.lastname: Horner
authors.forename: A
authors.initials: A
authors.lastname: Guilhaume
authors.forename: Y
authors.initials: Y
authors.lastname: Cazals
mesh_terms: D000818:Animals; D001284:Atrophy / Q000473:pathology; D003051:Cochlea / Q000648:ultrastructure*; D004195:Disease Models, Animal; D004487:Edema / Q000473:pathology*; D004710:Endolymph; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000648:ultrastructure*; D007759:Labyrinth Diseases / Q000473:pathology*