title: Initiation and enhancement of bone formation. A review.
abstract: Knowledge of some of the fundamental biochemical factors that may influence the initiation and continued growth of bone-forming cell lines is presented. The discussion is limited to those factors shown experimentally to be present locally in bone tissue and synthesized in the environment of bone-forming cells. The current state of knowledge of basic research findings on osteogenic factors is given in detail. Cooperative actions of these locally produced and systemic factors are the primary stimuli that result in increased bone growth and volume.
authors.affiliation: Nuffield Department of Orthopedics, University of Oxford, Nuffield Orthopedic Centre, England.
authors.forename: J T
authors.initials: JT
authors.lastname: Triffitt
mesh_terms: D000818:Animals; D001846:Bone Development; D002454:Cell Differentiation; D005347:Fibroblasts / Q000166:cytology; D006133:Growth Substances / Q000096:biosynthesis; D006801:Humans; D010012:Osteogenesis
chemical_list: D006133:Growth Substances