title: A prospective study of neuropsychological sequelae in children with brain tumors.
abstract: Surgery and radiotherapy are the primary modalities of treatment for pediatric brain tumors. Despite the widespread use of these treatments, little is known of their acute effects (within one year posttreatment) on neuropsychological functions. An understanding of acute treatment effects may provide valuable feedback to neurosurgeons and a baseline against which delayed sequelae may be evaluated. This study compares pre- and posttherapy neuropsychological test performance of pediatric brain tumor patients categorized into two groups on the basis of treatment modalities: surgery (n = 7) and radiotherapy (n = 7). Treatment groups were composed of children aged 56 to 196 months at the time of evaluation with heterogeneous tumor diagnoses and locations. Comparisons of pretherapy findings with normative values using confidence intervals indicated that both groups performed within the average range on most measures. Outstanding deficits at baseline were observed on tests of fine-motor, psychomotor, and timed language skills, and are likely to be attributable to tumor-related effects. Comparisons of pre- versus posttherapy neuropsychological test findings indicated no significant interval changes for either group. Results suggest that surgery and radiotherapy are not associated with acute effects on neuropsychological functions.
authors.affiliation: Department of Pediatrics, University of Texas M.D. Anderson Hospital and Tumor Institute, Houston 77030.
authors.forename: J D
authors.initials: JD
authors.lastname: Bordeaux
authors.forename: R E
authors.initials: RE
authors.lastname: Dowell
authors.forename: D R
authors.initials: DR
authors.lastname: Copeland
authors.forename: J M
authors.initials: JM
authors.lastname: Fletcher
authors.forename: D J
authors.initials: DJ
authors.lastname: Francis
authors.forename: J
authors.initials: J
authors.lastname: van Eys
mesh_terms: D000293:Adolescent; D001921:Brain / Q000528:radiation effects*; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000523:psychology*; D009483:Neuropsychological Tests; D011183:Postoperative Complications / Q000523:psychology*; D011832:Radiation Injuries / Q000523:psychology*; D011879:Radiotherapy Dosage