Excitant amino acids and audiogenic seizures in the genetically epilepsy-prone rat. II. Efferent seizure propagating pathway.
Previous studies indicate that the inferior colliculus is the brain stem auditory nucleus most sensitive to the chemical blockade of audiogenic seizures in the genetically epilepsy-prone rat. Other auditory structures do not appear to be as important. This study attempted to define the efferent pathways involved in propagation of the seizure from the colliculus to the spinal cord where the motor components of the convulsion are generated. This study also determined whether certain nuclei which have been implicated in the propagation of seizures in other epilepsy models are involved in audiogenic seizures. The excitant amino acid antagonist, 2-amino-7-phosphonoheptanoate, was infused bilaterally into several of those sites. The drug was effective in significantly reducing seizure severity with infusion of 5 nmol bilaterally into the midbrain and the pontine reticular formation or the substantia nigra. However, similar drug doses were not effective when infused into the entopeduncular nucleus even though prominent behavioral effects were observed with this infusion. Infusion of 2-amino-7-phosphonoheptanoate into the prepiriform cortex resulted in a small but significant reduction in seizure severity. These results suggest that inhibition of excitatory transmission within the substantia nigra and the reticular formation effectively blocks the output pathway for the audiogenic seizures, whereas the role of the prepiriform cortex in this process is relatively minor.
Millan
M H
MH
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield 62708.
Meldrum
B S
BS
Boersma
C A
CA
Faingold
C L
CL
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000161:Acoustic Stimulation / Q000009:adverse effects; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D004525:Efferent Pathways / Q000378:metabolism / Q000502:physiology*; D005260:Female; D008297:Male; D051381:Rats; D012154:Reticular Formation / Q000187:drug effects; D012640:Seizures / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D013378:Substantia Nigra / Q000187:drug effects
D000596:Amino Acids; D015763:2-Amino-5-phosphonovalerate; C031231:2-amino-7-phosphonoheptanoic acid