Different reactivities of monoclonal antibodies to ganglioside lactones.
Six murine monoclonal antibodies were found to react with ganglioside GD2 lactone as well as purified ganglioside GD2. However, the reactivities of these antibodies to various ganglioside lactones were found to differ from each other. Four antibodies only reacted with GD2 lactones, while the other two cross-reacted with lactones of other gangliosides such as GD1b and GT1b.
Tai
T
T
Tokyo Metropolitan Institute of Medical Science, Japan.
Kawashima
I
I
Tada
N
N
Ikegami
S
S
D000818:Animals; D000911:Antibodies, Monoclonal; D001923:Brain Chemistry; D002417:Cattle; D002855:Chromatography, Thin Layer; D005732:Gangliosides / Q000276:immunology* / Q000302:isolation & purification; D007783:Lactones; D013329:Structure-Activity Relationship
D000911:Antibodies, Monoclonal; D005732:Gangliosides; D007783:Lactones