title: Efficacy and safety of albendazole against experimentally induced Fasciola hepatica infections in goats.
abstract: Forty 8-week-old goats were allocated to five groups of equal size to determine the optimal dosage of albendazole against experimentally induced 14-week-old Fasciola hepatica infections. Albendazole suspension given orally at 5.0, 7.5, 10.0 and 15 mg kg-1 of body weight was 73.3, 88.2, 88.3 and 95.9% effective, respectively, when compared to untreated controls. Mean number of F. hepatica in the untreated control goats was 75.4. No signs of toxicity were observed. When albendazole was given to eight, 8-week-old goats orally at 75 mg kg-1 (five times the optimal dosage), no signs of toxicity were observed.
authors.affiliation: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.
authors.forename: W J
authors.initials: WJ
authors.lastname: Foreyt
mesh_terms: D015766:Albendazole; D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005210:Fasciola hepatica / Q000187:drug effects*; D005211:Fascioliasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D005260:Female; D006041:Goats / Q000469:parasitology*; D008297:Male
chemical_list: D001562:Benzimidazoles; D015766:Albendazole