[Physiopathology of the mechanism of activation of neutrophils: a future pathway?].
Numerous agonists such as chemotactic factors, phorbol esters, calcium ionophores, arachidonic acid or particles induce a cascade of events associated to oxygen reduction, the oxidative burst, in phagocytes and specially in neutrophils. Diverse transductional pathways involved in the oxidative burst were described. Moreover, various pathologies of the transductional pathways in different cell systems were recently observed. We think that the study of neutrophils constitutes first an excellent model of Cell Biology and second a putative model of the physiopathology of the transductional pathways.
Capo
C
C
Laboratoire d'Immunologie, Hôpital de Sainte Marguerite, Marseille.
André
P
P
Mege
J L
JL
Benoliel
A M
AM
Bongrand
P
P
D000208:Acute Disease; D001172:Arthritis, Rheumatoid / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D007295:Inositol Phosphates / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D010195:Pancreatitis / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D011547:Pseudohypoparathyroidism / Q000378:metabolism
D007295:Inositol Phosphates; D008565:Membrane Proteins; D011493:Protein Kinase C; D010100:Oxygen; D002118:Calcium
Etude de la physiopathologie des mécanismes d'activation des neutrophiles: une voie d'avenir?