The effect of sodium hyaluronate on the corneal epithelium. An ultrastructural study.
The effect of sodium hyaluronate (NaHa) 1% and 0.1% was studied on 14-day chick embryo corneal epithelium by scanning electron microscopy. It was found that NaHa 1% or 0.1% had no toxic effects on the chick corneal epithelium and the normal architecture of the cells and the morphology of the microvilli was well preserved. A combination of NaHa 0.1% and benzalkonium chloride (BAK) 0.01% reduced the toxic effect of BAK on the surface corneal epithelium. NaHa 0.1% provided a better protection of the corneal epithelium against dryness than hydroxyethylcellulose (HEC) 0.1% or phosphate buffer saline (PBS).
Wysenbeek
Y S
YS
Department of Ophthalmology, Beilinson Medical Center, Petah Tikva, Israel.
Loya
N
N
Ben Sira
I
I
Ophir
I
I
Ben Shaul
Y
Y
D000818:Animals; D001548:Benzalkonium Compounds / Q000494:pharmacology; D002482:Cellulose / Q000031:analogs & derivatives / Q000494:pharmacology; D002642:Chick Embryo; D004728:Endothelium, Corneal / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D006820:Hyaluronic Acid / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D010710:Phosphates / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology
D001548:Benzalkonium Compounds; D010710:Phosphates; D012965:Sodium Chloride; D002482:Cellulose; D006820:Hyaluronic Acid; C002283:hydroxyethylcellulose