Propylthiouracil disposition in older hypothyroid patients.
The pharmacokinetic disposition of propylthiouracil (PTU) after a single oral dose was studied in 6 severely hypothyroid patients. Severity of disease, as indicated by thyroid-stimulating hormone concentration, was inversely related to plasma clearance of PTU. There were trends to increased apparent volume of distribution and plasma half-life for PTU as a function of age. The large apparent volume of distribution for PTU in these patients compared to euthyroid and hyperthyroid subjects, after a single drug dose, suggests that hypothyroidism as well as chronic drug ingestion must be considered as possible factors mediating this change.
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Division of Clinical Pharmacology, Montreal General Hospital, Winnipeg, Canada.
Abu-Bakare
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Gardiner
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D000368:Aged; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011441:Propylthiouracil / Q000493:pharmacokinetics*; D013960:Thyroid Function Tests
D011441:Propylthiouracil