Cellular requirements of IgE-antibody regulation.
Regulation of IgE antibody response is T-cell dependent. It has been suggested that IL-4 (BSF-1) induces the expression of Fc epsilon RII on B-lymphocytes. Soluble molecules of the FC epsilon RII with various molecular weights represent IgE-binding factors which according to the current opinion either enhance or suppress the IgE-antibody response. In mice IgE suppressive factors were obtained, which inhibited IgE-synthesis in vitro and in vivo. IgE suppressive factors were also obtained by incubating MLN-cells with monoclonal IgE. In humans IgE binding factors are present within serum of normal donors. In atopics IgE-BF is apparently complexed with IgE. Thus, it becomes clear that the expression of IgE-bearing lymphocytes as well as the secretion of IgE is cytokine mediated.
König
W
W
RUHR-Universitt Bochum, Institut für Hygiene and Mikrobiologie, Bochum, FRG.
Pfeil
P
P
Hofmann
U
U
Bujanowski-Weber
J
J
Knöller
I
I
D000818:Animals; D002352:Carrier Proteins / Q000494:pharmacology*; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000494:pharmacology; D015847:Interleukin-4; D007378:Interleukins / Q000494:pharmacology; D008222:Lymphokines / Q000494:pharmacology; D051379:Mice
D002352:Carrier Proteins; D006133:Growth Substances; D007376:Interleukin-2; D007378:Interleukins; D008222:Lymphokines; D015847:Interleukin-4; D007073:Immunoglobulin E