title: [Use of high-purity insulins in the treatment of patients with diabetes mellitus].
abstract: A total of 43 patients aged 16-62 with moderately severe and severe type I diabetes mellitus of 2-27 years duration were observed. The patients were admitted to hospital with decompensation of metabolic processes. In order to achieve compensation monocomponent insulins were administered in an individual dose depending on the levels of glycemia and glucosuria and a scheme of drug administration (2 times continuously, i.v. using the Biostator apparatus). The duration of therapy was 4 months. A hypoglycemic effect in relation to immunological and hemorheological indices was assessed. A hypoglycemic effect was noted in all the patients. A positive effect of high-purity insulins on immunological and hemorheological indices was revealed. These insulins can be used for prevention of diabetic angiopathies.
authors.forename: V G
authors.initials: VG
authors.lastname: Spesivtseva
authors.forename: V I
authors.initials: VI
authors.lastname: Pokryshkin
authors.lastname: Belokrinitskiĭ
authors.forename: T V
authors.initials: TV
authors.lastname: Koroleva
authors.forename: G G
authors.initials: GG
authors.lastname: Mamaeva
mesh_terms: D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007328:Insulin / Q000302:isolation & purification / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D007328:Insulin
vernacular_title: Primenenie vysokoochishchennykh insulinov dlia lecheniia bol'nykh sakharnym diabetom.