title: Iron- and manganese-containing superoxide dismutases can be distinguished by analysis of their primary structures.
abstract: The iron- and manganese-containing superoxide dismutases have very similar three-dimensional structures but can be distinguished by various biochemical means. The primary structures of six manganese-containing and three iron-containing superoxide dismutases are known. Analysis of the aligned amino acid sequences of these enzymes taken together with structural data from X-ray diffraction studies demonstrates that the two classes of enzyme can be distinguished on the basis of a small number of single-site substitutions that are positioned in and close to the active site of the enzyme.
authors.affiliation: European Molecular Biology Laboratory (EMBL), Heidelberg, FRG.
authors.forename: M W
authors.initials: MW
authors.lastname: Parker
authors.forename: C C
authors.initials: CC
authors.lastname: Blake
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001419:Bacteria / Q000201:enzymology; D006801:Humans; D007501:Iron; D007527:Isoenzymes; D008345:Manganese; D051379:Mice; D008969:Molecular Sequence Data; D011487:Protein Conformation; D013045:Species Specificity; D013482:Superoxide Dismutase
chemical_list: D007527:Isoenzymes; D008345:Manganese; D007501:Iron; D013482:Superoxide Dismutase