The effect of PGF2 alpha-estrumate on the secretion and composition of abomasal juice in sheep during H2-histaminic receptor blockade with cimetidine.
The effect of PGF2 alpha was investigated on the secretion of abomasal juice in sheep after blockade of the H2-histaminic receptor with intravenous cimetidine (150-200 mg). Cimetidine inhibited abomasal juice secretion diminishing juice volume and the content of acid and pepsin in it. During this inhibition intramuscular injection of PGF2 alpha 2.0-4.0 micrograms/kg of body weight caused an increase of these parameters. In control experiments histamine administered (23-28 micrograms/kg) after cimetidine failed to increase the secretion of abomasal juice confirming thus complete blockade of the H2-histaminic receptor. The obtained results demonstrated that the stimulating effect of PGF2 alpha on abomasal juice secretion was not mediated by the H2-histaminic receptor.
Dejneka
J
J
Department of Animal Physiology, Agricultural Academy, Wrocław.
Lukaszewska
J
J
Paradowski
L
L
Załucki
G
G
D000018:Abomasum / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D003008:Cloprostenol / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008297:Male; D010447:Peptide Hydrolases / Q000378:metabolism; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D011970:Receptors, Histamine H2 / Q000187:drug effects; D012756:Sheep
D011461:Prostaglandins F, Synthetic; D011970:Receptors, Histamine H2; D003008:Cloprostenol; D002927:Cimetidine; D010447:Peptide Hydrolases