title: Muscle high energy phosphates in chronic peripheral vascular disease.
abstract: There is little information available concerning the alterations in skeletal muscle energy metabolism which occur in response to chronic arterial occlusive disease. In addition, the effect of arterial reconstruction on skeletal muscle energy metabolism in patients with peripheral vascular disease has not been defined. Needle biopsies were obtained from the quadriceps femoris muscle of 7 patients with aortoiliac disease and 15 patients with femoropopliteal disease and from the gastrocnemius muscle of 9 patients with femoropopliteal disease. Muscle samples were analyzed for ATP, ADP, AMP, phosphocreatine, creatine, and lactate. Eleven patients were rebiopsied after vascular reconstruction. Patients with rest pain had decreased total adenine nucleotides, energy charge potential, and ATP/ADP ratios as compared to those of controls. ATP levels were significantly decreased in muscle samples obtained distal to the arterial occlusion (i.e., quadriceps/aortoiliac, gastrocnemius/femoropopliteal) in patients with rest pain (compared with controls). ATP levels did not differ significantly from those of controls in muscle samples obtained from patients with claudication. However, energy charge potential was significantly decreased in all patients with claudication regardless of biopsy site and location of arterial occlusive disease. Normalization of muscle energy metabolism was not demonstrated following arterial reconstruction. We conclude that resting skeletal muscle energy metabolism is abnormal in patients with chronic arterial insufficiency and that progression of disease toward more severe ischemia is associated with more marked derangement. Whether the possible beneficial effects of revascularization on muscle energy metabolism are masked by the concurrent effect of injury in the early postoperative period remains to be clarified.
authors.affiliation: Department of Surgery, College of Physicians & Surgeons, Columbia University, New York, New York 10032.
authors.forename: G J
authors.initials: GJ
authors.lastname: Todd
authors.forename: B
authors.initials: B
authors.lastname: Van de Wiele
authors.forename: J
authors.initials: J
authors.lastname: Askanazi
authors.forename: K
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: D H
authors.initials: DH
authors.lastname: Elwyn
authors.forename: J M
authors.initials: JM
authors.lastname: Kinney
authors.forename: K
authors.initials: K
authors.lastname: Reemtsma
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000378:metabolism* / Q000601:surgery; D001707:Biopsy, Needle / Q000379:methods; D002908:Chronic Disease; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007511:Ischemia / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D010710:Phosphates / Q000378:metabolism*
chemical_list: D010710:Phosphates