title: A multicenter study of the safety and efficacy of naproxen: analysis of blood pressure.
abstract: A multicenter study was conducted to determine safety and efficacy of naproxen, 500 mg twice daily, administered for 4 weeks to osteoarthritis (OA) patients. OA symptoms improved in the study population. The study population included 97 patients, 43 of whom were 65 years of age or older. Forty-four of the 97 patients had a history of hypertension; 42 of these took antihypertensive medication before and during the study. Baseline blood pressure (BP) was measured in most patients while they were receiving their prior nonsteroidal antiinflammatory drug (NSAID) therapy; from that baseline, no increase in BP was seen in the hypertensive or normotensive patients after 4 weeks of naproxen therapy. In patients whose BP was controlled by antihypertensive agents, BP remained under control during naproxen therapy.
authors.affiliation: Chief of Medicine, Beth Israel Hospital, Passaic, NJ.
authors.forename: M A
authors.initials: MA
authors.lastname: Goldberg
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000150:complications; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009288:Naproxen / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy; D012449:Safety
chemical_list: D009288:Naproxen