title: Vertebral fusion dynamics in the thoracic and lumbar spine induced by allogenic demineralized bone matrix combined with autogenous bone marrow. An experimental study in rabbits.
abstract: The aim of this study was to examine the capability of grafts consisting of demineralized bone matrix combined with autogenous bone marrow to enhance fusion in the thoracic and lumbar spines in rabbits. Thirteen rabbits were operated on, using a posterior approach. A combined intertransverse and interspinous fusion was performed. Fusion was achieved first in the lumbar segments, then in the thoraco-lumbar segments and lastly in the thoracic segments. The best results were achieved in the lumbar spine, where complete fusion occurred in 83%. The combination of demineralized bone matrix and autogenous bone marrow proved to be a reliable transplant material for experimental spinal fusion.
authors.affiliation: Clinica Ortopedica e Traumatologica dell'Università Ospedale S. Matteo, Pavia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Ragni
authors.forename: T S
authors.initials: TS
authors.lastname: Lindholm
authors.forename: T C
authors.initials: TC
authors.lastname: Lindholm
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation; D001857:Bone Matrix / Q000032:analysis / Q000637:transplantation*; D008159:Lumbar Vertebrae / Q000502:physiology* / Q000601:surgery; D008903:Minerals / Q000032:analysis; D010012:Osteogenesis; D011817:Rabbits; D013123:Spinal Fusion / Q000379:methods; D013904:Thoracic Vertebrae / Q000502:physiology* / Q000601:surgery; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D008903:Minerals