title: Dedifferentiated chondrosarcoma.
abstract: The cases of forty-six patients who had dedifferentiated chondrosarcoma were reviewed. Two groups were identified: one in which a low-grade malignant chondrosarcoma was the precursor lesion and one in which a moderate to high-grade malignant chondrosarcoma was the precursor lesion. The radiographic features of these lesions ranged from that of a cartilaginous lesion that appeared to be benign to that of a destructive osteolytic tumor in which the cartilaginous component was overshadowed by the dedifferentiated component. Only three of the forty-six patients survived for more than two years. Resection alone, even when it was wide or radical, was not successful in controlling this lethal sarcoma.
authors.affiliation: 1st Orthopaedic Clinic, Istituto Ortopedico Rizzoli, Bologna, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Capanna
authors.forename: F
authors.initials: F
authors.lastname: Bertoni
authors.forename: G
authors.initials: G
authors.lastname: Bettelli
authors.forename: P
authors.initials: P
authors.lastname: Picci
authors.forename: P
authors.initials: P
authors.lastname: Bacchini
authors.forename: D
authors.initials: D
authors.lastname: Present
authors.forename: A
authors.initials: A
authors.lastname: Giunti
authors.forename: M
authors.initials: M
authors.lastname: Campanacci
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology; D002813:Chondrosarcoma / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed