title: Study of possible genetic predisposition to endemic goitre among the Fur and Baggara tribes of the Sudan.
abstract: The overall prevalence rate of endemic goitre among the Fur and Baggara tribes of Western Sudan was found to be 74%. Family studies in 60 nuclear families showed a significantly higher incidence of endemic goitre among the offspring of affected parents than among the offspring of normal parents. This suggests a possible genetic predisposition to endemic goitre. The proportion of phenylthiocarbamide (PTC) non-tasters was found to be 13% among the goitrous subjects compared to 17.5% among the non-goitrous subjects. However, the association with PTC as well as with 6 blood-genetic markers, was not statistically significant.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Khartoum, Sudan.
authors.forename: R A
authors.initials: RA
authors.lastname: Bayoumi
authors.forename: T S
authors.initials: TS
authors.lastname: Taha
authors.forename: N
authors.initials: N
authors.lastname: Saha
mesh_terms: D001798:Blood Proteins / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006042:Goiter / Q000235:genetics*; D008297:Male; D010670:Phenylthiourea; D013397:Sudan; D013649:Taste / Q000502:physiology
chemical_list: D001798:Blood Proteins; D010670:Phenylthiourea