[Effects of vaccination in urinary infections caused by Escherichia coli in rats].
The preventive effects of the immunomodulator P40 on the experimental E. coli infection of the lower urinary tract of the rat have been reported previously. In the present paper are presented the results obtained with the aid of vaccination using the same experimental model of infection in the rat. Active specific immunization of the animals with a vaccine consisting of the same strain as that used for infecting the rats afforded significant protection toward the infection. It is concluded that such vaccines could also be used in humans, either alone or in combination with other therapies with the aim at preventing recurrencies or relapses of infections of the lower urinary tract which were resistant to antibiotherapy.
Mathieu
D
D
Service de Microbiologie, Hôpital Paul-Brousse, Villejuif, France.
Jacques
L
L
Auer
J
J
Bizzini
B
B
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D004926:Escherichia coli / Q000276:immunology*; D004927:Escherichia coli Infections / Q000517:prevention & control*; D007115:Immunization Schedule; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014552:Urinary Tract Infections / Q000517:prevention & control*; D014611:Vaccination
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines
Effet d'une vaccination sur les infections urinaires à "Escherichia coli" chez le rat.