[Basophil leukemia, development of a chronic myeloid leukemia. Apropos of a case and review of the literature].
Basophilic leukemia is a rare disease accounting for less than 2% of all hematopoietic malignancies and little is known about the best therapeutical approach. We report a case of basophilic leukemia occurring as an accelerated phase of chronic myelogenic leukemia in a 50 year old man with a past history of uranium and thorium exposure. He was successfully treated with intensive chemotherapy and total body irradiation followed by autologous peripheral stem cell transplantation. Such an approach has never been reported in this disease. However, the benefit on survival could not be evaluated because of a fatal opportunistic infection. The cases of basophilic leukemia reported in the literature are discussed.
Lossignol
D
D
Département d'Hématologie, Institut Jules Bordet, Université Libre de Bruxelles, Belgique.
Bron
D
D
Debusscher
L
L
Regnier
R
R
Delforge
A
A
Klastersky
J
J
Stryckmans
P
P
D001491:Basophils; D016026:Bone Marrow Transplantation; D006801:Humans; D007938:Leukemia / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D007951:Leukemia, Myeloid / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014916:Whole-Body Irradiation
Leucémie à basophiles, évolution d'une leucémie myéloïde chronique. A propos d'un cas et revue de la littérature.