Anthelmintic activity of continuous low doses of fenbendazole into the rumen of sheep.
Fenbendazole (FBZ) was continuously infused for 30 days into the rumen of 103 lambs which had mature or developing benzimidazole-susceptible or thiabendazole-resistant Haemonchus contortus and susceptible Trichostrongylus colubriformis infections. Ovicidal, larvicidal and adulticidal activities were exhibited against benzimidazole-susceptible and benzimidazole-resistant H. contortus worms by FBZ at a dose level of greater than or equal to 0.2 mg kg-1 body weight day-1. Reasonably consistent high level efficacy against H. contortus was obtained with dose levels greater than 0.4 mg kg-1. Excellent control of susceptible T. colubriformis worms was achieved with the lowest dose tested of 0.4 mg kg-1 day-1. The intraruminal infusion critical study method is a tool to determine the feasibility of incorporating a candidate anthelmintic compound in a continuous sustained-release rumen device formulation. The anthelmintic profile of FBZ obtained by low-level intraruminal administration suggests that it would be a potential candidate.
Boisvenue
R J
RJ
Animal Health Discovery Research Department, Eli Lilly and Co., Greenfield, IN 46140.
Colestock
E L
EL
Hendrix
J C
JC
D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D005260:Female; D005273:Fenbendazole / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006188:Haemonchiasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D006189:Haemonchus / Q000187:drug effects* / Q000254:growth & development; D008297:Male; D012417:Rumen / Q000469:parasitology; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology; D014251:Trichostrongyloidea / Q000187:drug effects*; D014252:Trichostrongyloidiasis / Q000662:veterinary*; D014253:Trichostrongylosis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D014254:Trichostrongylus / Q000187:drug effects* / Q000254:growth & development
D001562:Benzimidazoles; D005273:Fenbendazole