Complementary addressed modification of double-stranded DNA within a ternary complex.
Double-stranded DNA containing a d(pG)18.d(pC)18 sequence was shown to be selectively alkylated in the vicinity of this fragment using the 5'-p-(N-2-chloroethyl-N-methylamino)benzylamide of deoxyribooligocytidylate, CIRCH2NH(pdC)n (n = 9,15), in conditions favouring triple-stranded complex formation.
Fedorova
O S
OS
Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk.
Knorre
D G
DG
Podust
L M
LM
Zarytova
V F
VF
D000478:Alkylation; D001483:Base Sequence; D004247:DNA; D006863:Hydrogen-Ion Concentration; D008969:Molecular Sequence Data; D009150:Mustard Compounds; D010880:Piperidines; D011066:Poly C; D011089:Polydeoxyribonucleotides
D009150:Mustard Compounds; D010880:Piperidines; D011089:Polydeoxyribonucleotides; C016681:poly(dG).poly(dC); C023826:poly(dC); D011066:Poly C; C025881:4(N)-(2-chloroethyl-N-methylamino)benzylamine; C032727:piperidine; D004247:DNA