Effect of cephalosporins on fascial healing after celiotomy.
A 7 day course of either cefonicid or cefazolin significantly reduced mean wound breaking weight after midline celiotomy in Sprague-Dawley rats compared with control animals. This detrimental effect was not seen when each drug was administered as a single preoperative dose. Even a 3 day course of cefonicid was associated with a significant reduction in the weight required to disrupt a healing abdominal closure. An increased incidence of incisional hernias was also noted among animals treated for 7 days with cefonicid or cefazolin. Shorter antibiotic regimens were not associated with an increased frequency of incisional herniation.
Scher
K S
KS
Department of Surgery, Wright State University School of Medicine, Dayton, Ohio.
Scott-Conner
C E
CE
Montany
P F
PF
D000818:Animals; D002435:Cefamandole / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D002437:Cefazolin / Q000627:therapeutic use / Q000633:toxicity*; D015790:Cefonicid; D004334:Drug Administration Schedule; D000071938:Fasciotomy; D005260:Female; D007813:Laparotomy; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains; D013529:Surgical Wound Dehiscence / Q000209:etiology*; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D002435:Cefamandole; D015790:Cefonicid; D002437:Cefazolin