Correspondence of results from hepatocyte studies with in vivo response.
Isolated hepatocyte systems are being examined in our laboratory for a number of applications, including alternatives to animal testing. This report summarizes findings from studies with chlorinated aliphatics, acetaminophen, nitrotoluenes, and cyanide and its antidotes that relate to in vivo toxicity and validation of these systems for cytotoxicity screening.
Tyson
C A
CA
SRI International, Menlo Park, CA 94025.
D000826:Animal Testing Alternatives; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology*