Gonadal development and gametogenesis in the hypogonadal mouse are restored by gene transfer.
These results describe controlled regulation of a mammalian neural gene in transgenic mice. Analysis of truncated GnRH-GAP genes in transgenic mice will enable us to define the DNA sequences responsible for this control. Furthermore, by separate mutation of the GnRH and GAP coding sequences we will be able to determine the relative importance of these two peptides in the development and maintenance of reproductive function.
Mason
A J
AJ
Department of Developmental Biology, Genentech, Inc., South San Francisco, California 94080.
Pitts
S L
SL
Nikolics
K
K
Szonyi
E
E
Wilcox
J N
JN
Seeburg
P H
PH
Stewart
T A
TA
D000818:Animals; D003001:Cloning, Molecular; D005718:Gametogenesis; D005835:Genitalia / Q000196:embryology / Q000254:growth & development; D007987:Gonadotropin-Releasing Hormone / Q000235:genetics*; D007006:Hypogonadism / Q000196:embryology / Q000235:genetics* / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic / Q000502:physiology*; D011498:Protein Precursors / Q000235:genetics*
D011498:Protein Precursors; C050502:gonadotropin releasing hormone associated peptide; D007987:Gonadotropin-Releasing Hormone