title: Systemic antibiotic prophylaxis and reconstructive ear surgery.
abstract: This paper reports a multicentre, controlled, blind, prospective, randomized study into the use of prophylactic systemic antibiotics in myringoplasty surgery. Seventy-one individuals were clinically and bacteriologically assessed both preoperatively, and for a period of 8 weeks postoperatively. The results showed that antibiotic prophylaxis did not eradicate bacterial pathogens already present in preoperative ears, nor did it prevent their development during the postoperative period. The observation that an ear was wet or dry gave no indication of the actual presence or absence of pathogenic organisms.
authors.affiliation: Department of Otolaryngology, University Hospital of Wales, Cardiff.
authors.forename: W V
authors.initials: WV
authors.lastname: Carlin
authors.forename: T H
authors.initials: TH
authors.lastname: Lesser
authors.forename: D G
authors.initials: DG
authors.lastname: John
authors.forename: C
authors.initials: C
authors.lastname: Fielder
authors.forename: D G
authors.initials: DG
authors.lastname: Carrick
authors.forename: P L
authors.initials: PL
authors.lastname: Thomas
authors.forename: S
authors.initials: S
authors.lastname: Hill
mesh_terms: D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004432:Ear, Middle / Q000382:microbiology*; D005260:Female; D005436:Floxacillin / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D009225:Myringoplasty; D010033:Otitis Media / Q000382:microbiology / Q000473:pathology; D011183:Postoperative Complications / Q000382:microbiology* / Q000517:prevention & control; D011446:Prospective Studies; D011549:Pseudomonas / Q000302:isolation & purification; D011897:Random Allocation; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013297:Streptococcus pyogenes / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D005436:Floxacillin; D000667:Ampicillin