title: Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats.
abstract: A sonicated liposome suspension of gamma-aminobutyric acid (GABA) and phosphatidylserine (liposome-entrapped GABA), intraperitoneally administered in rats, inhibited EEG epileptic activity induced by penicillin, whereas GABA did not. A significant increase (20.4%) in brain radioactivity accumulation occurred at 5 min after i.p. administration of [14C]GABA associated with phosphatidylserine in comparison with the administration of [14C]GABA; such an increase persisted after 20 min. However, the accumulation of radioactivity into brain synaptosomes demonstrated a 24.1% increase at 5 min and subsequently showed a 43.3% increase at 20 min after injection of liposome-entrapped GABA. The above findings suggest that phosphatidylserine stimulates exogenous GABA uptake into brain GABAergic nerve terminals.
authors.affiliation: Institute of Neurology, University of Genova, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Loeb
authors.forename: U M
authors.initials: UM
authors.lastname: Marinari
authors.forename: E
authors.initials: E
authors.lastname: Benassi
authors.forename: G
authors.initials: G
authors.lastname: Besio
authors.forename: D
authors.initials: D
authors.lastname: Cottalasso
authors.forename: A
authors.initials: A
authors.lastname: Cupello
authors.forename: M
authors.initials: M
authors.lastname: Maffini
authors.forename: P
authors.initials: P
authors.lastname: Mainardi
authors.forename: M A
authors.initials: MA
authors.lastname: Pronzato
authors.forename: P A
authors.initials: PA
authors.lastname: Scotto
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D008081:Liposomes / Q000008:administration & dosage; D008297:Male; D010718:Phosphatidylserines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000493:pharmacokinetics*
chemical_list: D008081:Liposomes; D010718:Phosphatidylserines; D005680:gamma-Aminobutyric Acid