[Immunomodulating action of myelopeptides in severe closed experimental craniocerebral injury in rats].
An immunocorrective effect of myelopeptides (MP) isolated from pig bone marrow cell culture supernatant in the early posttraumatic period in rats with severe cranial injury has been assessed. MP administration prevented cellular devastation of thymus and bone marrow, as well as spleen hyperplasia. The most marked MP effect was observed within the first 24 h after its administration. MP affected the functional and migration properties of both the entire population of lymphoid cells and individual subpopulations. MP had a pronounced protective effect against Staph. aureus infection during cranial trauma. MP completely prevented the death of animals and reduced more than 3-fold Staph. aureus persistence in the organism of animals. Anti-stress and protective effects of MP open vast prospects for their therapeutic and preventive application in the clinical practice.
Lisianyĭ
N I
NI
Radzhievskiĭ
A A
AA
Zakharova
L A
LA
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D001930:Brain Injuries / Q000188:drug therapy* / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D008297:Male; D009842:Oligopeptides; D010455:Peptides / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D012481:Salmonella Infections, Animal / Q000188:drug therapy / Q000473:pathology; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013552:Swine; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D014946:Wound Infection / Q000188:drug therapy / Q000473:pathology; D014949:Wounds, Nonpenetrating / Q000188:drug therapy* / Q000473:pathology
D000276:Adjuvants, Immunologic; D009842:Oligopeptides; D010455:Peptides; C048617:myelopeptides
Immunomoduliruiushchee deĭstvie mielopeptidov pri tiazheloĭ zakrytoĭ éksperimental'noĭ cherepno-mozgovoĭ travme u krys.