Unusual breast masses. The sequential development of mammary tuberculosis and Hodgkin's disease in a young woman.
A left breast mass developed in association with pulmonary tuberculosis in a woman 26 years of age. Eight years later, rapidly fatal Hodgkin's Disease with chest wall erosion by involved mediastinal nodes simulating a breast lump developed. Subsequently, a discrete breast mass due to mammary Hodgkin's disease developed. Involvement of the breast by both tuberculosis and Hodgkin's disease, two diseases often associated with immune dysfunction, in a patient with dysmorphic features and a strong family history of tuberculosis, raises the possibility of an underlying genetic defect. This defect probably involves the immune system.
Graeme-Cook
F
F
Department of Pathology, Trinity College, Dublin, Ireland.
O'Briain
D S
DS
Daly
P A
PA
D000328:Adult; D001706:Biopsy; D001940:Breast / Q000473:pathology; D001941:Breast Diseases / Q000235:genetics / Q000473:pathology*; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D013997:Time Factors; D014384:Tuberculosis, Female Genital / Q000235:genetics / Q000473:pathology*