title: Tamm-Horsfall protein is a marker of renal and extra-renal rhabdoid tumours.
abstract: A monoclonal antibody (MAb) to Tamm-Horsfall protein (THP) was used to stain 6 renal rhabdoid tumours (RRT) and 2 primary extra-renal rhabdoid tumours (E-RRT). One of the E-RRT was a tumour from the posterior fossa of a 3-year-old child and the other was a lump from the right side of the neck in an 18-month-old girl. Five of 6 RRT and both cases of E-RRT were positive for THP. Both cases of E-RRT also reacted with vimentin and cytokeratin MAbs. On electron microscopy, cells from both E-RRT were seen to contain concentric whorls of intermediate filaments characteristic of rhabdoid tumours. Viable tissues from one RRT and one E-RRT (the posterior fossa tumour) were available for tissue culture. Ninety-five percent of the cells growing out of both tumours were polygonal and approximately 5% of these cells were THP-positive.
authors.affiliation: Christie Hospital, Manchester, UK.
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.forename: S M
authors.initials: SM
authors.lastname: Jakate
authors.forename: H B
authors.initials: HB
authors.lastname: Marsden
authors.forename: P
authors.initials: P
authors.lastname: Kumar
authors.forename: B
authors.initials: B
authors.lastname: Jasani
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D002675:Child, Preschool; D005260:Female; D006258:Head and Neck Neoplasms / Q000032:analysis; D006801:Humans; D007159:Immunologic Tests; D007223:Infant; D007680:Kidney Neoplasms / Q000032:analysis*; D009088:Mucoproteins / Q000032:analysis*; D009363:Neoplasm Proteins / Q000032:analysis*; D058949:Uromodulin
chemical_list: D014408:Biomarkers, Tumor; D009088:Mucoproteins; D009363:Neoplasm Proteins; C548612:UMOD protein, human; D058949:Uromodulin