In vivo depression of reserve albumin binding capacity by cadmium: a preliminary evaluation.
The effect of cadmium upon the depression of reserve albumin binding capacity (%RABC) was investigated in male, New Zealand white rabbits at daily dosages of 0.65 mg and 0.90 mg Cd/kg body weight. Correlations of % RABC to the duration of exposure were strongest at the higher dosage. After 30-35 days exposure, the decline in % RABC was partially reversed. Levels of total protein in urine increased sharply within a few days after the % RABC had been reduced by cadmium to their lowest values.
Roberts
C A
CA
United States Department of Labor, Occupational Safety and Health Administration, Long Beach, CA 90802.
Clark
J M
JM
D000818:Animals; D002104:Cadmium / Q000097:blood / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D011485:Protein Binding; D011507:Proteinuria / Q000652:urine; D011817:Rabbits; D012709:Serum Albumin / Q000378:metabolism*
D012709:Serum Albumin; D002104:Cadmium