Comparison of alum-precipitated aqueous extracts and modified ragweed tyrosine adsorbate vaccine in the treatment of ragweed hay fever.
Thirty-five ragweed-sensitive patients received immunotherapy with either alum-precipitated aqueous extracts (AP) or modified ragweed tyrosine adsorbate vaccine (Pollinex-R). Symptoms decreased with AP therapy only. Immunologically, there was a blunted specific IgE response and little specific IgG increase associated with both groups. Alum-precipitated aqueous extracts appeared to be more efficacious than Pollinex-R.
Hebert
J
J
Division of Clinical Immunology, SMBD-Jewish General Hospital, Montreal, Quebec, Canada.
Small
P
P
D000327:Adsorption; D000534:Alum Compounds; D000535:Aluminum; D000917:Antibody Formation; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D010936:Plant Extracts / Q000627:therapeutic use*; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*; D013431:Sulfates; D014443:Tyrosine; D014867:Water
D000534:Alum Compounds; D010936:Plant Extracts; D013431:Sulfates; D014867:Water; C041524:aluminum sulfate; D014443:Tyrosine; D000535:Aluminum