Effect of bile anionic polypeptidic fraction on the fate of cholesterol carried by liposomes in the rat.
[14C]Cholesterol associated with liposomes with or without anionic polypeptidic fraction was administered intravenously to the rat. The cholesterol originated from liposomes including anionic polypeptidic fraction is secreted in bile much later, is stored in liver in higher quantity, and is metabolized into bile salts in lesser quantity during the 4 hr of experimentation than the cholesterol issued from liposomes exempt of anionic polypeptidic fraction. From these results it can be postulated that the cholesterol associated with liposomes containing anionic polypeptidic fraction might be directed in a particular liver pathway.
Martigne
M
M
INSERM U-130, Marseille, France.
Domingo
N
N
Chanussot
F
F
Nalbone
G
G
Lafont
H
H
Hauton
J
J
D000818:Animals; D001646:Bile / Q000502:physiology*; D002250:Carbon Radioisotopes; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008081:Liposomes / Q000008:administration & dosage*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010455:Peptides / Q000494:pharmacology* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D008081:Liposomes; D010455:Peptides; D002784:Cholesterol