Failure of kindling to alter susceptibility to kainic acid.
In this study, the interaction between electrical kindling and kainic acid seizures was investigated. Prepubescent male rats were kindled using hourly, suprathreshold stimulations. Two days later the kindled rats and their non-kindled controls received systemic injections of either 6, 10, or 17 mg/kg of kainic acid. No differences in response to kainic acid were seen between the two groups. These data demonstrate that the kindled brain does not uniformly exhibit a lower seizure threshold to all convulsants, but is dependent on the agents subsequently used to induce the seizures.
Thompson
J L
JL
Department of Neurology and Pediatrics, Medical College of Georgia, Veterans Medical Center, Augusta 30912.
Bryan
M
M
Bates
T
T
Holmes
G L
GL
D000818:Animals; D003292:Convulsants / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D007608:Kainic Acid / Q000008:administration & dosage*; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time; D012640:Seizures / Q000139:chemically induced*
D003292:Convulsants; D007608:Kainic Acid