title: Does 'sugar' permeability reflect macromolecular absorption? A comparison of the gastro-intestinal uptake of lactulose and beta-lactoglobulin in the neonatal guinea pig.
abstract: Intestinal closure to cow's milk beta-lactoglobulin occurs within 6 days of birth in the guinea pig. Passive intestinal permeability to lactulose persists through the suckling period. The uptake of small water-soluble markers does not reflect macromolecular absorption, and has no place in the measurement of immunologic protein handling by the gut.
authors.affiliation: MRC Dunn Nutritional Laboratory, University of Cambridge, UK.
authors.forename: L T
authors.initials: LT
authors.lastname: Weaver
authors.forename: R R
authors.initials: RR
authors.lastname: Coombs
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D002463:Cell Membrane Permeability; D004187:Disaccharides / Q000493:pharmacokinetics*; D006168:Guinea Pigs; D007408:Intestinal Absorption; D007782:Lactoglobulins / Q000493:pharmacokinetics* / Q000652:urine; D007792:Lactulose / Q000493:pharmacokinetics* / Q000652:urine; D046911:Macromolecular Substances
chemical_list: D004187:Disaccharides; D007782:Lactoglobulins; D046911:Macromolecular Substances; D007792:Lactulose