title: Acute and chronic ketanserin in essential hypertension: antihypertensive mechanisms and pharmacokinetics.
abstract: 1. In nine patients with essential hypertension, following single and multiple doses of ketanserin, assessments were made of blood pressure and heart rate, QT interval, and pressor responses to phenylephrine and angiotensin II. 2. Significant reductions in blood pressure occurred for 6 h after the first dose, on average 23/14 mm Hg supine, and there was a comparable antihypertensive effect after 1 month's treatment. 3. There were small but significant rightward shifts (1.5 to 2-fold) in the phenylephrine pressor-response curves but no changes in the responsiveness to angiotensin II. 4. The QT interval (QTc) was significantly increased after 1 month's treatment: at 1 h after dosing 334 +/- 32 ms after 1 month of ketanserin compared with 302 +/- 31 ms after placebo. 5. The elimination half-life and AUC for ketanserin were both significantly increased at steady state compared with the first dose: respectively 13.4 vs 4.3 h for half-life and 830 vs 437 ng ml-1 h for AUC. 6. Ketanserin had no significant effects on baroreflex function, plasma renin activity, aldosterone, catecholamines and 24 h urinary excretion.
authors.affiliation: University Department of Materia Medica, Stobhill General Hospital, Glasgow.
authors.forename: R
authors.initials: R
authors.lastname: Donnelly
authors.forename: H L
authors.initials: HL
authors.lastname: Elliott
authors.forename: P A
authors.initials: PA
authors.lastname: Meredith
authors.forename: J L
authors.initials: JL
authors.lastname: Reid
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007650:Ketanserin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D010656:Phenylephrine / Q000097:blood; D011224:Prazosin / Q000627:therapeutic use; D012083:Renin / Q000097:blood
chemical_list: D000804:Angiotensin II; D010656:Phenylephrine; D000450:Aldosterone; D007650:Ketanserin; D012083:Renin; D009638:Norepinephrine; D011224:Prazosin