title: Adverse reactions and immunogenicity in adults to regular and increased dosage of diphtheria vaccine.
abstract: Booster doses of 3 Lf or 7.5 Lf of a regular diphtheria vaccine were given to 200 previously immunized adult volunteers. The toxoid was prepared from toxin with a purity of 2100 Lf/mg protein nitrogen and adsorbed to aluminium phosphate. Systemic reactions were rare and no severe symptoms were observed. Local reactions occurred in 40-50% of the vaccinees, but in only 7.5% were they of clinical significance, i.e. an area of redness/swelling greater than 5 cm. The two doses did not cause significant differences in reaction rates, and the 7.5 Lf dose elicited a better antitoxin response. Thus, a dose of 7.5 Lf diphtheria toxoid of similar purity can safely be given to adults in vaccines.
authors.affiliation: Department of Infectious Diseases, Ostra sjukhuset, Göteborg, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Björkholm
authors.forename: M
authors.initials: M
authors.lastname: Granström
authors.forename: M
authors.initials: M
authors.lastname: Wahl
authors.forename: C E
authors.initials: CE
authors.lastname: Hedström
authors.forename: L
authors.initials: L
authors.lastname: Hagberg
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D004166:Diphtheria Antitoxin / Q000032:analysis*; D004168:Diphtheria Toxoid / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D007117:Immunization, Secondary / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
chemical_list: D004166:Diphtheria Antitoxin; D004168:Diphtheria Toxoid