title: Scleroderma: DR antigens, autoantibodies and clinical manifestations.
abstract: The relationship between anticentromere antibodies (ACA), antitopoisomerase I or Scleroderma 70 (Scl-70) antibodies, HLA-DR antigens, and clinical manifestations of scleroderma were examined in 51 patients defined by ARA criteria. No association between a given HLA-DR antigen and either ACA or anti-Scl-70 was found. Statistically significant associations were noted for patients with ACA who had a lower frequency of arthritis and longer disease duration; anti-Scl-70 patients were more likely to be males with a higher frequency of pulmonary, cardiac and sicca symptoms.
authors.affiliation: Department of Medicine (Division of Clinical Immunology and Rheumatology), School of Medicine, University of Alabama at Birmingham 35294.
authors.forename: G S
authors.initials: GS
authors.lastname: Alarcón
authors.forename: G A
authors.initials: GA
authors.lastname: McCarty
authors.forename: P
authors.initials: P
authors.lastname: Lanyon
authors.forename: R M
authors.initials: RM
authors.lastname: Phillips
authors.forename: R T
authors.initials: RT
authors.lastname: Acton
authors.forename: B O
authors.initials: BO
authors.lastname: Barger
mesh_terms: D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D002503:Centromere / Q000276:immunology; D004264:DNA Topoisomerases, Type I; D005260:Female; D005455:Fluorescent Antibody Technique; D006681:HLA-D Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000276:immunology; D012595:Scleroderma, Systemic / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D009687:Nuclear Proteins; C048100:Scl 70 antigen, human; D004264:DNA Topoisomerases, Type I