Altered metabolic function of the pulmonary microcirculation. Early detection of lung injury and possible functional significance.
The normal lung is the site of intense metabolic activity, largely associated with the endothelial cell. Depressed pulmonary metabolic function is seen in a wide variety of experimental animal models of acute lung injury, and is also demonstrated in ARDS patients. The evaluation of lung metabolic activity may prove to be a sensitive probe for the detection of the earliest phases of acute lung injury, as well as a guide to the severity of injury or response to therapy. Depressed lung metabolic function may play a role in the intrapulmonary and/or systemic pathophysiology of ARDS.
Wiedemann
H P
HP
Department of Pulmonary Disease, Cleveland Clinic Foundation, Ohio.
Gillis
C N
CN
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000378:metabolism; D000809:Angiotensins / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001920:Bradykinin / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000098:blood supply* / Q000378:metabolism; D008833:Microcirculation / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism; D012128:Respiratory Distress Syndrome / Q000378:metabolism* / Q000503:physiopathology; D014666:Vasomotor System / Q000503:physiopathology
D000806:Angiotensin-Converting Enzyme Inhibitors; D000809:Angiotensins; D001679:Biogenic Amines; D011453:Prostaglandins; D001920:Bradykinin