title: [Intra-arterial chemotherapy, using the hepatic artery, in metastases of colorectal carcinoma].
abstract: Hepatic metastasis is the major cause of death in advanced cancer of the colon and rectum. Various modes of therapy have been attempted with only partial success. Infusion of cytotoxic agents into the hepatic artery has allowed a higher concentration of drug into the tumor capillary bed than is achievable with intravenous administration. We review the data on therapeutic outcome, administration techniques and toxicity of hepatic arterial chemotherapy for colorectal cancer metastatic to the liver.
authors.affiliation: Dpto. de Oncología, Facultad de Medicina, Universidad de Navarra, Pamplona.
authors.forename: O F
authors.initials: OF
authors.lastname: Hidalgo
authors.forename: A C
authors.initials: AC
authors.lastname: Gil
authors.forename: W
authors.initials: W
authors.lastname: Campbell
authors.forename: V
authors.initials: V
authors.lastname: Hidalgo
authors.forename: M
authors.initials: M
authors.lastname: Santos
authors.forename: I
authors.initials: I
authors.lastname: Henríquez
authors.forename: S
authors.initials: S
authors.lastname: Martín
authors.forename: M
authors.initials: M
authors.lastname: Sureda
authors.forename: L M
authors.initials: LM
authors.lastname: Antón
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000295:instrumentation*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000517:prevention & control / Q000556:secondary*
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Quimioterapia intra-arterial hepática en las metástasis del carcinoma colorrectal.