title: Local depot methylprednisolone injection for painful anal Crohn's disease.
abstract: Treatment, by local depot methylprednisolone injection, of severe anal pain in Crohn's disease not associated with overt sepsis is reported. It has given dramatic relief in 5 patients, but has not been successful in 2 patients where anal disease was in continuity with severe rectal involvement. Treatment has been effective for greater than 1 yr, and no complication of the technique has been found on regular follow-up. When compared with previous attempts at treatment, the beneficial results attained with methylprednisolone injection suggest that the effect is more than a placebo response. Careful patient selection to exclude overt sepsis or severe rectal disease is recommended before proceeding to steroid injection.
authors.affiliation: University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom.
authors.forename: L E
authors.initials: LE
authors.lastname: Hughes
authors.forename: D R
authors.initials: DR
authors.lastname: Donaldson
authors.forename: J G
authors.initials: JG
authors.lastname: Williams
authors.forename: B A
authors.initials: BA
authors.lastname: Taylor
authors.forename: H L
authors.initials: HL
authors.lastname: Young
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001004:Anus Diseases / Q000188:drug therapy*; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077555:Methylprednisolone Acetate; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000893:Anti-Inflammatory Agents; D000077555:Methylprednisolone Acetate; D008775:Methylprednisolone