Involvement of PAF-acether in anaphylactic bronchoconstriction induced in guinea pigs by aerosolized antigen.
Bronchoconstriction following the aerosolization of PAF-acether or antigen to guinea pigs induces autodesensitization, but the responses to direct spasmogenic substances are not modified. Bronchoconstriction by PAF-acether is not reduced when it is aerosolized to passively sensitized animals previously desensitized by repeated inhalations of the allergen (ovalbumin). In contrast, when passively sensitized animals are initially desensitized to PAF-acether by repeated inhalations of this agonist, ovalbumin aerosolization induces a bronchoconstriction which is significantly reduced when compared with the response obtained in nondesensitized animals though, in this case, the response to aerosolized histamine is not modified. Thus, PAF-acether is released during intrapulmonary anaphylactic shock induced by aerosolized ovalbumin and can be a prime candidate for its development.
Lagente
V
V
Unité associée Institut Pasteur/INSERM U285, Paris, France.
Cirino
M
M
Desquand
S
S
Lefort
J
J
Vargaftig
B B
BB
D000336:Aerosols; D000707:Anaphylaxis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D001986:Bronchial Spasm / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D002867:Chromones / Q000494:pharmacology; D003888:Desensitization, Immunologic; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D008297:Male; D010047:Ovalbumin / Q000276:immunology / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000276:immunology / Q000494:pharmacology*; D011738:Pyrilamine / Q000494:pharmacology; D013997:Time Factors
D000336:Aerosols; D000941:Antigens; D002867:Chromones; D010972:Platelet Activating Factor; D006632:Histamine; C006312:FPL 55712; D010047:Ovalbumin; D011738:Pyrilamine