[Dynamic immunological and cytochemical markers in the induced differentiation of the K-562 cell line].
The possibility of TPA-induced differentiation of K-562 cell line was studied. Monoclonal antibodies against differentiating antigens of HAE erythroid lineage and against myelomonocytic ICO lineage raised in the USSR Cancer Research Centre were used. Changes in immunological and cytochemical indexes suggest that K-562 cell differentiation goes in the erythroid direction. The cells lost early differentiation and acquired late differentiation markers.
Roslavtseva
T A
TA
Baryshnikov
A Iu
AIu
Frenkel'
M A
MA
D000911:Antibodies, Monoclonal / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D004912:Erythrocytes / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D009000:Monocytes / Q000276:immunology; D010641:Phenotype; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013997:Time Factors
D000911:Antibodies, Monoclonal; D013755:Tetradecanoylphorbol Acetate
Dinamika immunologicheskikh i tsitokhimicheskih markerov pri indutsirovannoĭ differentsirovke kletochnoĭ linii K-562.