Corneal toxicity of propamidine.
Two patients with Acanthamoeba keratitis developed a corneal abnormality following prolonged treatment with topical 0.1% [corrected] propamidine isethionate. In both instances, withdrawal of drug therapy resulted in a gradual clearing of the keratopathy, with no permanent sequelae. The changes we observed may be confused with those of active Acanthamoeba infection.
Johns
K J
KJ
Department of Ophthalmology, Vanderbilt University Medical Center, Nashville, TN 37232.
Head
W S
WS
O'Day
D M
DM
D000048:Acanthamoeba; D000287:Administration, Topical; D000328:Adult; D000562:Amebiasis / Q000188:drug therapy; D000578:Amidines / Q000009:adverse effects*; D000818:Animals; D001550:Benzamidines / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003316:Corneal Diseases / Q000139:chemically induced* / Q000473:pathology; D003560:Cysts / Q000139:chemically induced; D005260:Female; D006801:Humans; D007634:Keratitis / Q000209:etiology; D008297:Male
D000578:Amidines; D001550:Benzamidines; C046651:propamidine isethionate