title: [Prescription of Theostat 300 as a single evening dose].
abstract: Sixteen patients with asthma and/or chronic obstructive lung disease were treated for 8 days by scored tablets of sustained-release theophylline. Treatment was administered as a single evening dose per day, 2 hours after dinner, at a daily dosage of 10 mg/kg/day of theophylline. The theophylline curve remained in the theoretical therapeutic zone of 8 to 15 mcg/ml for about 14 hours; the clinical efficacy, evaluated on the basis of the improvement in the signs and symptoms, was satisfactory. The clinical acceptability was good apart from insomnia observed during the first 2 days of treatment.
authors.affiliation: Service de Pathologie respiratoire et d'Allergologie, CHRU Le Cluzeau, Limoges.
authors.forename: J
authors.initials: J
authors.lastname: Germouty
authors.forename: C
authors.initials: C
authors.lastname: Bida
authors.forename: L
authors.initials: L
authors.lastname: Moreau
mesh_terms: D001249:Asthma / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013806:Theophylline / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D003692:Delayed-Action Preparations; D013806:Theophylline
vernacular_title: Prescription du Théostat 300 en prise unique le soir.