title: Responses of sodium balance, blood pressure, and other variables to sodium loading in Papua New Guinea highlanders.
abstract: For determination of the responses of sodium balance, blood pressure, and other relevant variables to Na loading in people with a low intake of Na, 10 male Papua New Guinea highland subjects were given additional Na at two levels (128 and 256 mmol/d) for 10 d after a 3-d control period of low-Na diet. Na loading caused a marked positive balance of Na, decreases of aldosterone concentration and renin activity in the plasma, and a decrease of urinary aldosterone excretion. The blood pressure, particularly that measured at noon, increased in the latter half of the Na-loading period, the increase being significant in the group given 256 mmol of sodium daily: the systolic and diastolic blood pressure increased from 92 +/- 8 over 56 +/- 7 mm Hg in the control period to 102 +/- 7 over 60 +/- 4 mm Hg in the latter half of the test period (p less than 0.05).
authors.affiliation: Nutrition Research Laboratory, Tokyo Metropolitan Institute of Gerontology, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Rikimaru
authors.forename: Y
authors.initials: Y
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Okuda
authors.forename: N
authors.initials: N
authors.lastname: Kajiwara
authors.forename: S
authors.initials: S
authors.lastname: Miyatani
authors.forename: M P
authors.initials: MP
authors.lastname: Alpers
authors.forename: H
authors.initials: H
authors.lastname: Koishi
mesh_terms: D000328:Adult; D001794:Blood Pressure; D006801:Humans; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D010219:Papua New Guinea; D012084:Renin-Angiotensin System; D012964:Sodium / Q000378:metabolism*; D012965:Sodium Chloride / Q000008:administration & dosage; D014882:Water-Electrolyte Balance
chemical_list: D012965:Sodium Chloride; D012964:Sodium; D009584:Nitrogen