title: Asbestos-related pleural and parenchymal fibrosis: detection with high-resolution CT.
abstract: Twenty-nine subjects with occupational asbestos exposure and clinical asbestosis were examined with high-resolution computed tomography (HRCT) to determine its sensitivity, relative to that of conventional computed tomography (CT), for detection of benign asbestos-related disease. Thin-section HRCT scans were obtained at five discrete levels through the mid and lower thorax in both prone and supine positions. The same technique was used in 34 age-similar control patients. Parenchymal abnormalities were seen most frequently in the posterior portion of the lung bases in the asbestos-exposed subjects. HRCT prone scans enabled basal structural abnormalities to be reliably distinguished from gravity-related physiologic phenomena in 25 asbestos-exposed subjects. HRCT was more sensitive than CT in detection of both pleural and parenchymal fibrosis. In subjects with clinical asbestosis, HRCT demonstrated parenchymal abnormality in 96%, compared with 83% for CT. Similarly, pleural thickening was shown in 100% of subjects at HRCT, compared with 93% at CT. HRCT could be an important adjunct in the evaluation of asbestos-related pleuroparenchymal fibrosis. An HRCT study including prone scans is a sensitive, reliable means of detecting thoracic abnormalities in asbestos-exposed individuals.
authors.affiliation: Department of Radiology, University of California, San Francisco.
authors.forename: D R
authors.initials: DR
authors.lastname: Aberle
authors.forename: G
authors.initials: G
authors.lastname: Gamsu
authors.forename: C S
authors.initials: CS
authors.lastname: Ray
authors.forename: I M
authors.initials: IM
authors.lastname: Feuerstein
mesh_terms: D000328:Adult; D000368:Aged; D001195:Asbestosis / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D008875:Middle Aged; D009784:Occupational Diseases / Q000000981:diagnostic imaging; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging* / Q000209:etiology; D014057:Tomography, X-Ray Computed / Q000379:methods