Life-threatening complications of cardiac operations and occurrence of myocardial catecholamine bombs.
Myocardial catecholamine bombs (huge local intra-axonal accumulations of catecholamine, mainly norepinephrine, within cardiac tissue) were observed in (right auricular) myocardial biopsy specimens in 16 of 65 adult patients selected randomly from a series of elective cardiac operations. The occurrence of catecholamine bombs was in highly significant correlation (p less than 0.001) with the occurrence of life-threatening complications of cardiac operations (life-threatening arrhythmias [ventricular tachycardias, ventricular fibrillation, asystole], clinically evident perioperative myocardial infarction/postoperative low-output syndrome, death). There was a very close correlation between the occurrence of catecholamine bombs and life-threatening arrhythmias. Life-threatening arrhythmias occurred in 13 patients. Eight of them belonged to the group of 16 patients with catecholamine bombs and five belonged to the group of 49 patients with no bombs; the difference (8/16 versus 5/49) is very clear (p less than 0.001). It was our experience that dangerous arrhythmias related to catecholamine bombs may occur as late as during the second postoperative week. We believe our observations are of considerable clinical importance, because catecholamine bombs are easily identified by fluorescence microscopic examination of right auricular myocardial specimens retrieved intraoperatively, and patients at high risk can then be selected (during the operation) for more extensive and prolonged surveillance and possibly prophylactic treatment.
Kyösola
K
K
Department of Thoracic and Cardiovascular Surgery, University Central Hospital, Helsinki, Finland.
Mattila
T
T
Harjula
A
A
Kyösola
H
H
Waris
T
T
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000378:metabolism; D001369:Axons / Q000378:metabolism; D001706:Biopsy / Q000379:methods; D002303:Cardiac Output, Low / Q000209:etiology / Q000378:metabolism; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002395:Catecholamines / Q000378:metabolism*; D005260:Female; D006321:Heart / Q000294:innervation; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D011183:Postoperative Complications / Q000209:etiology / Q000378:metabolism*; D012307:Risk Factors
D002395:Catecholamines