S-adenosyl-L-methionine protects the hippocampal CA1 neurons from the ischemic neuronal death in rat.
We investigated the effect of S-adenosyl-L-methionine (SAMe) on the prevention of the delayed neuronal death in rats subjected to transient and brief forebrain ischemia. As the results, SAMe dose-dependently protected the hippocampal CA1 neurons from degeneration and necrosis, whose effect was suppressed by simultaneous administration of S-adenosyl-L-homocysteine, a potent inhibitor in transmethylation. No protective effect was observed in CDP-choline, phosphatidylcholine and L-methionine. Therefore, it is necessary for the prevention of the delayed neuronal death to enhance cerebral SAMe level and to activate transmethylation using SAMe as a methyl donor in postischemic brain.
Sato
H
H
Research Laboratories, Fuji Chemical Industry Co., Ltd., Toyama, Japan.
Hariyama
H
H
Moriguchi
K
K
D000818:Animals; D002462:Cell Membrane / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology; D006624:Hippocampus / Q000473:pathology*; D002546:Ischemic Attack, Transient / Q000473:pathology*; D008297:Male; D008715:Methionine / Q000494:pharmacology; D008745:Methylation; D009336:Necrosis; D009410:Nerve Degeneration / Q000187:drug effects; D009474:Neurons / Q000473:pathology*; D010713:Phosphatidylcholines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012435:S-Adenosylhomocysteine / Q000494:pharmacology; D012436:S-Adenosylmethionine / Q000494:pharmacology*
D010713:Phosphatidylcholines; D003566:Cytidine Diphosphate Choline; D012436:S-Adenosylmethionine; D012435:S-Adenosylhomocysteine; D008715:Methionine