title: Energy-dependent efflux mediated by class L (tetL) tetracycline resistance determinant from streptococci.
abstract: The class L (TetL) tetracycline resistance determinant from streptococci specified resistance and an energy-dependent decreased accumulation of tetracycline in both Streptococcus faecalis and Escherichia coli. Using E. coli, we showed that the reduced uptake resulted from active efflux. The streptococcal class M determinant, known to render the protein synthesis machinery of S. faecalis resistant to tetracycline inhibition, did not alter tetracycline transport in either host.
authors.affiliation: Department of Molecular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111.
authors.forename: L M
authors.initials: LM
authors.lastname: McMurry
authors.forename: B H
authors.initials: BH
authors.lastname: Park
authors.forename: V
authors.initials: V
authors.lastname: Burdett
authors.forename: S B
authors.initials: SB
authors.lastname: Levy
mesh_terms: D004734:Energy Metabolism / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects*; D013753:Tetracycline Resistance; D013754:Tetracyclines / Q000494:pharmacology*
chemical_list: D013754:Tetracyclines