Cell stimulation by haemopoietic lymphokines.
Haemopoietic cells appear to respond to two distinct classes of growth factors, cell-bound molecules and lymphokines. Stimulation by lymphokines can be modelled by IL-3-dependent cell lines, and evidence is presented that such stimulation may represent a novel system of cell signalling unrelated to those where stimulation is a progression from a resting cell state into DNA synthesis and mitosis. The concept of a "rolling" cycle is introduced, and discussed in relationship to recent results suggesting that phosphorylation of a specific 33 kDa protein may be part of the control mechanism. Based on responses to different IL-3s, it is suggested that one function of lymphokines is to modulate responses to others by mechanisms other than regulation of receptor expression.
Garland
J M
JM
Department of Cell and Structural Biology, Manchester Medical School, U.K.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003115:Colony-Stimulating Factors / Q000096:biosynthesis; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D007377:Interleukin-3 / Q000502:physiology; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000494:pharmacology*; D010750:Phosphoproteins / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D003115:Colony-Stimulating Factors; D007377:Interleukin-3; D008222:Lymphokines; D010750:Phosphoproteins