title: Effects of the two new anthelmintic agents CGP 6140 and CGP 20376 on adult Paragonimus uterobilateralis in the experimental host Sigmodon hispidus.
abstract: The new compounds CGP 6140 and CGP 20376 were tested for their anthelmintic activity against adult Paragonimus uterobilateralis in experimentally infected Sigmodon hispidus. Both drugs were effective at a dosage of 2 x 100 mg/kg b.w. given orally with an interval of six hours between the doses. This regimen killed 80% of the flukes collected on Days 7 and 11 after treatment with CGP 6140 and 100% of the flukes collected on Days 5, 7, and 11 after therapy with CGP 20376. Both compounds showed no effect at single doses of 25, 50 and 100 mg/kg or with 12.5 and 25 mg/kg/day given on four consecutive days.
authors.affiliation: Department of Helminthology, Bernhardt Nocht Institute, Hamburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Weber
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D003411:Arvicolinae; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010237:Paragonimiasis / Q000188:drug therapy*; D010238:Paragonimus / Q000187:drug effects; D010879:Piperazines / Q000627:therapeutic use*; D013844:Thiazoles / Q000627:therapeutic use*
chemical_list: D000871:Anthelmintics; D010879:Piperazines; D013844:Thiazoles; C051745:CGP 20376; C051744:amocarzine