Copper deficiency and tissue glutathione concentration in the rat.
Copper deficiency in rats increased renal vein and arterial (heart) plasma GSH concentration by approximately 50%. There was no change in plasma GSSG concentration. Renal vein plasma GSSG/GSH ratio was decreased in copper deficiency, which is consistent with previous reports showing a copper-dependent thiol oxidase activity in the renal basement membrane. No change occurred in arterial plasma GSSG/GSH ratio. Hepatic GSH concentrations were also elevated by 50% in copper deficiency, GSSG concentrations were unaffected, but GSSG/GSH ratio was depressed. Renal and cardiac tissue GSH and GSSG were unaffected by copper deficiency. The decreased SOD activity and GSH-Px activity observed in copper deficiency may contribute to increased hepatic and plasma GSH concentrations.
Allen
K G
KG
Rowett Research Institute, Bucksburn, Aberdeen, Scotland, United Kingdom.
Arthur
J R
JR
Morrice
P C
PC
Nicol
F
F
Mills
C F
CF
D000818:Animals; D001158:Arteries; D003300:Copper / Q000172:deficiency*; D005978:Glutathione / Q000097:blood / Q000378:metabolism*; D006352:Heart Ventricles; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D012082:Renal Veins
D003300:Copper; D005978:Glutathione