title: Practical limits on the biomagnetic inverse process determined from in vitro measurements in spherical conducting volumes.
abstract: A technique of locating current dipoles in spherical conducting volumes by determining the location of the magnetic field maximum and inverting the magnetic field equations was developed and the expected localisation errors were predicted. AC current dipoles were placed in spheres of uniform conductivity. Each dipole's magnetic field was measured and its location was calculated by determining the angle between the magnetic field null and maximum and using an iterative inverse solution to the magnetic field equations. Absolute agreement between predicted magnetic field strengths and actual magnetic field measurements was within 5%. A study of the effect of signal to noise ratio and number of data points in the analysis indicates that dipole localisation of approximately 1 mm is achievable for a signal to noise ratio greater than 10 decibels (S/N greater than 10 db).
authors.affiliation: Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland 20707.
authors.forename: J S
authors.initials: JS
authors.lastname: Hansen
authors.forename: H W
authors.initials: HW
authors.lastname: Ko
authors.forename: R S
authors.initials: RS
authors.lastname: Fisher
authors.forename: B
authors.initials: B
authors.lastname: Litt
mesh_terms: D001921:Brain; D006801:Humans; D008280:Magnetics; D008433:Mathematics; D008954:Models, Biological