title: Formaldehyde adducts of glutathione. Structure elucidation by two-dimensional n.m.r. spectroscopy and fast-atom-bombardment tandem mass spectrometry.
abstract: Aqueous mixtures of formaldehyde and glutathione react to form a variety of cyclized adducts in addition to S-hydroxymethylglutathione. The adducts are in labile equilibrium with each other and are not readily separated. The structures of two of the other major adducts were determined by concerted application of 13C-1H two-dimensional chemical-shift correlation, fast-atom-bombardment mass spectrometry and tandem mass spectrometry to the adduct mixtures in aqueous solution.
authors.affiliation: University of Cambridge Chemical Laboratory, U.K.
authors.forename: S
authors.initials: S
authors.lastname: Naylor
authors.forename: R P
authors.initials: RP
authors.lastname: Mason
authors.forename: J K
authors.initials: JK
authors.lastname: Sanders
authors.forename: D H
authors.initials: DH
authors.lastname: Williams
authors.forename: G
authors.initials: G
authors.lastname: Moneti
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D005557:Formaldehyde; D005978:Glutathione; D007477:Ions; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008970:Molecular Weight
chemical_list: D007477:Ions; D005557:Formaldehyde; D005978:Glutathione