Renal involvement in Mycobacterium leprae infected mice. Histopathological, bacteriological and immunofluorescence study.
Swiss albino mice were inoculated in the footpads with Mycobacterium leprae obtained from untreated lepromatous patient. The kidneys obtained from the animals sacrificed during different periods were processed for histopathology, presence of AFB and immunofluorescence studies. Renal lesions, AFB and immune complex deposits were seen in the infected animals. Such findings have not been studied in great detail in experimental leprosy earlier.
Vaishnavi
C
C
Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ganguly
N K
NK
Kumar
B
B
Chakravarti
R N
RN
Kaur
S
S
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D000942:Antigens, Bacterial / Q000032:analysis; D005455:Fluorescent Antibody Technique; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D007668:Kidney / Q000382:microbiology / Q000473:pathology*; D007918:Leprosy / Q000150:complications / Q000382:microbiology / Q000473:pathology*; D051379:Mice; D009166:Mycobacterium leprae / Q000276:immunology / Q000302:isolation & purification
D000907:Antibodies, Bacterial; D000936:Antigen-Antibody Complex; D000942:Antigens, Bacterial