title: Late considerations in the treatment of low-grade malignancy cerebral tumors with iodine-125 brachytherapy.
abstract: The authors report their series of 45 patients harboring inoperable, low-grade cerebral neoplasms, treated in the past 6 years with 125I stereotactic brachytherapy. The majority of these tumors were grade I and II astrocytomas and oligodendrogliomas (82.2%). A 2.6- to 6-year follow-up shows good results in 65.6% with reduction or disappearance of the lesions on CT images and good social reentry. Nine patients (23.7%) died prior to follow-up. Young patients (less than 40 years) responded well to interstitial radiotherapy, while patients over 40 with the same histological findings of low-grade tumors responded poorly to this type of treatment. Diffuse infiltrating cortico-subcortical tumors, optochiasmatic gliomas, hypothalamic and lower brainstem neoplasms do not respond satisfactorily to 125I radioisotope implantations.
authors.affiliation: Division of Neurosurgery, Bellaria Hospital, Bologna, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Frank
authors.forename: A P
authors.initials: AP
authors.lastname: Fabrizi
authors.forename: G
authors.initials: G
authors.lastname: Gaist
authors.forename: R
authors.initials: R
authors.lastname: Frank-Ricci
authors.forename: M
authors.initials: M
authors.lastname: Piazzi
authors.forename: F
authors.initials: F
authors.lastname: Spagnolli
mesh_terms: D001918:Brachytherapy; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D013238:Stereotaxic Techniques; D014057:Tomography, X-Ray Computed
chemical_list: D007457:Iodine Radioisotopes