title: Noninvasive assessment of hemodynamic responses to exercise in pulmonary regurgitation after operations to correct pulmonary outflow obstruction.
abstract: The influence of pulmonary regurgitation (PR) on exercise capacity is unknown. The hemodynamic responses to exercise in postoperative patients with PR was determined using Doppler-measured regurgitant fraction to indicate PR severity. Maximal heart rate, oxygen consumption and workload capacity were measured during upright cycle ergometry. Cardiac output was measured at rest and during submaximal supine cycle ergometry by pulsed Doppler echocardiography. Oxygen consumption was simultaneously measured and exercise factor was calculated as the change in cardiac output per change in oxygen consumption. Twenty-seven patients were compared with 17 age-, size- and sex-matched control subjects. Patients with PR had larger right ventricles (p less than or equal to 0.001), lower heart rate response (p less than or equal to 0.05), lower maximal oxygen consumption (p less than or equal to 0.005) and lower workloads (p less than or equal to 0.005) when compared with normal control subjects during maximal exercise testing. Exercise factor was the same for both groups. Patients with PR were then separated into mild, moderate and severe groups. Patients with mild PR had a normal response to exercise. However, patients with moderate and severe PR had lower maximal oxygen consumptions and maximal workloads than control subjects. Control, mild and moderate PR groups had similar exercise factors. Patients with severe PR had markedly low cardiac output responses. PR is associated with reduced exercise capability, which is related to the severity of the PR.
authors.affiliation: Department of Pediatrics (Cardiology), University of Arizona, Health Sciences Center, Tucson 85724.
authors.forename: G R
authors.initials: GR
authors.lastname: Marx
authors.forename: R W
authors.initials: RW
authors.lastname: Hicks
authors.forename: H D
authors.initials: HD
authors.lastname: Allen
authors.forename: S J
authors.initials: SJ
authors.lastname: Goldberg
mesh_terms: D000293:Adolescent; D001011:Aorta / Q000503:physiopathology; D001783:Blood Flow Velocity; D002302:Cardiac Output; D002648:Child; D004452:Echocardiography; D006321:Heart / Q000503:physiopathology; D006330:Heart Defects, Congenital / Q000601:surgery; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D010101:Oxygen Consumption; D010807:Physical Endurance; D005082:Physical Exertion; D011183:Postoperative Complications; D011664:Pulmonary Valve / Q000503:physiopathology / Q000601:surgery*; D011665:Pulmonary Valve Insufficiency / Q000209:etiology / Q000503:physiopathology*; D011666:Pulmonary Valve Stenosis / Q000601:surgery