title: Bacterial chemotaxis. Cell flux model, parameter measurement, population dynamics, and genetic manipulation.
abstract: In this paper, we summarized our recent efforts toward accomplishing four key goals important for control of microbial population dynamics in nonmixed systems: (1) derivation of a cell population flux model based on individual cell properties; (2) measurement of the population random motility and chemotaxis parameters appearing in this model using a simple experimental assay; (3) quantitative understanding of the effects of cell motility and chemotaxis properties on microbial population dynamics; and (4) manipulation of chemotactic responses by genetic modification.
authors.affiliation: Department of Chemical Engineering, University of Pennsylvania, Philadelphia 19104.
authors.forename: D A
authors.initials: DA
authors.lastname: Lauffenburger
authors.forename: M
authors.initials: M
authors.lastname: Rivero
authors.forename: F
authors.initials: F
authors.lastname: Kelly
authors.forename: R
authors.initials: R
authors.lastname: Ford
authors.forename: J
authors.initials: J
authors.lastname: DiRienzo
mesh_terms: D001419:Bacteria / Q000166:cytology / Q000235:genetics; D018407:Bacterial Physiological Phenomena; D002465:Cell Movement; D002633:Chemotaxis; D004274:DNA, Recombinant; D008433:Mathematics; D008954:Models, Biological; D010957:Plasmids
chemical_list: D004274:DNA, Recombinant