[The resonance nature of the dependence of epithelial lesions of the small intestine in mice on the interval between injections of an S-phase-specific agent--hydroxyurea].
The dependence of the injury of murine small intestinal epithelium on the interval between multiple regular injections of hydroxyurea (HU) was investigated. Mice were injected 8 times with HU (5 mg per injection) in different experimental groups of animals, and the interval between injections varied from 6 to 19 hours. With the intervals between the injections close to 8 or 16.5 hours the resonance decrease of the injury was observed whereas the intervals of 6, 12 and 19 hours corresponded to maximum injury.
Dibrov
B F
BF
Ataullakhanov
A I
AI
Gel'fand
E V
EV
Gorodinskaia
V S
VS
Zhabotinskiĭ
A M
AM
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005260:Female; D006918:Hydroxyurea / Q000494:pharmacology*; D007399:Interphase / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013997:Time Factors
D006918:Hydroxyurea
Rezonansnyĭ kharakter zavisimosti porazheniia épiteliia tonkoĭ kishki mysheĭ ot intervala mezhdu in''ektsiiami S-fazospetsificheskogo agenta--oksimocheviny.