title: [Prevention of nephrotoxicity of amphotericin B during the treatment of deep candidiasis].
abstract: Previous observations suggest that tubulo-glomerular feedback could be involved in amphotericin B nephrotoxicity. We then investigated the influence of sodium status on the occurrence of renal damage during amphotericin B therapy. A retrospective survey demonstrated that impaired renal function occurred during therapy in 67 per cent of the patients who received amphotericin B alone and in 12 per cent of the patients who received amphotericin B and ticarcillin (parenteral sodium supplement of 100-150 meq per day). Prospective studies were then undertaken both in adults and children. Intravenous sodium supplement was given intravenously as routine prophylaxis with amphotericin B therapy. In all courses amphotericin B was successfully administered without deterioration in renal function. These results support the hypothesis that parenteral sodium supplementation reduces the frequency of developing impaired renal function during amphotericin B therapy.
authors.affiliation: Service de Néonatologie, Hôpital Bretonneau, Paris.
authors.forename: E
authors.initials: E
authors.lastname: Jacqz
authors.forename: R A
authors.initials: RA
authors.lastname: Branch
authors.forename: H
authors.initials: H
authors.lastname: Heidemann
authors.forename: Y
authors.initials: Y
authors.lastname: Aujard
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D002177:Candidiasis / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D011446:Prospective Studies; D012189:Retrospective Studies; D012964:Sodium / Q000627:therapeutic use*
chemical_list: D000666:Amphotericin B; D012964:Sodium
vernacular_title: Prévention de la néphrotoxicité de l'amphotéricine B au cours du traitement des candidoses profondes.