title: Central and peripheral hypotensive effects of the optical isomers of nicardipine, a dihydropyridine calcium channel antagonist, in rats.
abstract: Central and peripheral hypotensive effects of (+)- and (-)-nicardipine (1-10 micrograms/kg i.v. or i.c.v.) were investigated in normotensive and SH rats. The results suggest that a stereoselectivity exists for the peripheral and central hypotensive effects of the nicardipine isomers. (+)-Nicardipine was shown to be 3-8 times as potent as the (-) isomer in reducing blood pressure in all the experiments.
authors.affiliation: Département de Pharmacologie, Unité INSERM 228, Faculté de Médecine Broussais-Hôtel Dieu, Paris, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Brisac
authors.forename: P
authors.initials: P
authors.lastname: Champéroux
authors.forename: B
authors.initials: B
authors.lastname: Lucet
authors.forename: S
authors.initials: S
authors.lastname: Laurent
authors.forename: H
authors.initials: H
authors.lastname: Schmitt
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D009529:Nicardipine / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013237:Stereoisomerism
chemical_list: D009529:Nicardipine