Noncatalytic protein component of elastase from horse leucocytes. A protein with regulatory function.
1. Noncatalytic protein component (NPC), a strongly acidic protein (pH = 4.5) was separated from native horse leucocyte elastase 1. 2. This protein reduces elastinolytic properties of elastases: 1 and 2A probably by decreasing their isoelectric points. 3. A possible regulatory role of this protein may be inferred from a higher affinity of elastase 1 to NPC rather than to elastin.
Potempa
J
J
Institute of Molecular Biology, Jagiellonian University, Cracow, Poland.
Korzus
E
E
Silberring
J
J
Dubin
A
A
D000818:Animals; D001798:Blood Proteins / Q000502:physiology*; D004591:Electrophoresis, Polyacrylamide Gel; D006736:Horses; D007123:Immunoelectrophoresis, Two-Dimensional; D007700:Kinetics; D007962:Leukocytes / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000097:blood* / Q000302:isolation & purification
D001798:Blood Proteins; D010196:Pancreatic Elastase