Effect of pH on the production of irritation in a chamber irritation test.
This study was designed to investigate the relationship between alteration of skin surface pH and the development of skin irritation. Application of a phosphate/borate/acetate buffer adjusted to pH 4.0-10.5 in a standard chamber irritation test did not result in significant clinical irritation. This was true in spite of maintaining a markedly altered skin surface pH over an extended period of time. There was also no correlation between irritation and the pH of applied surfactant solutions. These results demonstrate that a prolonged disturbance of the "acid mantle" is not sufficient to produce clinical irritation.
Murahata
R I
RI
Department of New Science and Technology, Dial Technical Center, Scottsdale, AZ 85254.
Toton-Quinn
R
R
Finkey
M B
MB
D003902:Detergents / Q000009:adverse effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007509:Irritants; D012867:Skin / Q000187:drug effects*; D012915:Soaps / Q000009:adverse effects*; D013501:Surface-Active Agents / Q000009:adverse effects*
D003902:Detergents; D007509:Irritants; D012915:Soaps; D013501:Surface-Active Agents