[Mechanism of the development of thioridazine retinopathy].
Comparative electron microscopic, electrophysiological and biochemical studies of thioridazine influence on lipid peroxidation in vivo (rats, rabbits) and in vitro (model systems) were performed. It was shown that thioridazine retinopathy was not followed by an increase in lipid peroxidation and antioxidant (dibunol) failed to protect the retina against the destructive action of thioridazine. Moreover, thioridazine inhibited lipid peroxidation in model system.
Ivanina
T A
TA
Lebedeva
M N
MN
Sakina
N L
NL
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use; D008054:Lipid Peroxides / Q000096:biosynthesis; D011817:Rabbits; D011898:Ranidae; D051381:Rats; D012164:Retinal Diseases / Q000139:chemically induced* / Q000517:prevention & control; D013268:Stimulation, Chemical; D013881:Thioridazine / Q000633:toxicity*
D000975:Antioxidants; D008054:Lipid Peroxides; D002084:Butylated Hydroxytoluene; D013881:Thioridazine
Mekhanizmy razvitiia tioridazinovoĭ retinopatii.