title: Quinidine-induced lupus erythematosus-like syndrome: three case reports and a review of the literature.
abstract: Three patients with an LE-like syndrome secondary to quinidine are described. Twenty-two similar cases are reviewed. The clinical picture is characterized mainly by polyarthritis, pleuritis, fever and dermatitis. The common laboratory findings are positive antinuclear antibodies, absence of anti-DNA antibodies, thrombocytopenia, leukopenia and abnormal liver function tests. This LE-like syndrome may appear within days or up to several years after the start of quinidine treatment and disappears completely a few weeks after discontinuation of the drug.
authors.affiliation: Department of Internal Medicine A, Soroka Medical Center, Beer Sheva, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Sukenik
authors.forename: J
authors.initials: J
authors.lastname: Horowitz
authors.forename: A
authors.initials: A
authors.lastname: Katz
authors.forename: J
authors.initials: J
authors.lastname: Henkin
authors.forename: D
authors.initials: D
authors.lastname: Buskila
mesh_terms: D000368:Aged; D001168:Arthritis / Q000139:chemically induced; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000175:diagnosis; D008875:Middle Aged; D011802:Quinidine / Q000009:adverse effects*
chemical_list: D011802:Quinidine