title: Sickle cell E hemoglobinopathy and pregnancy.
abstract: The incidence of E hemoglobinopathies has been increasing in the United States. This is the first known case report of hemoglobin S/E in pregnancy. Management was based on the similarities of the S/E and S/beta-thalassemia hemoglobinopathies, and included partial exchange transfusion. Complications included fetal distress, congenital hydrocephalus, and cleft lip and palate. It appears that S/E and E/beta-thalassemia hemoglobinopathies may entail increased perinatal risks, but that favorable pregnancy outcomes may be anticipated with homozygous hemoglobin E or hemoglobin E trait.
authors.affiliation: Department of Obstetrics and Gynecology, Hutzel Hospital/Wayne State University, Detroit, Michigan.
authors.forename: A J
authors.initials: AJ
authors.lastname: Ramahi
authors.forename: L M
authors.initials: LM
authors.lastname: Lewkow
authors.forename: M P
authors.initials: MP
authors.lastname: Dombrowski
authors.forename: S F
authors.initials: SF
authors.lastname: Bottoms
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000628:therapy; D005260:Female; D006446:Hemoglobin E; D006453:Hemoglobinopathies / Q000628:therapy; D006455:Hemoglobins, Abnormal; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy
chemical_list: D006455:Hemoglobins, Abnormal; D006446:Hemoglobin E