title: [Prognostic significance of lacunar lesions in magnetic resonance tomography in multiple sclerosis].
abstract: 175 patients with definite multiple sclerosis underwent nuclear magnetic resonance imaging. T1-weighted images showed in 59 patients (34%) periventricular lesions with a central area of decreased signal intensity. They appear as lacunar defects in the walls of the lateral ventricle system. In accordance with neuropathological findings we suggest that in these plaques a cystic degeneration has replaced gliosis. Patients with cystic defects are characterized by a high activity of the disease (e.d. increased annual production of plaques) and a poor prognosis. Lacunae are found in the early stages of the disease and provide a prognostic sign in multiple sclerosis.
authors.affiliation: Neurologische Klinik, Hardtwaldkliniken, Zwesten.
authors.forename: W
authors.initials: W
authors.lastname: Weihe
authors.forename: A
authors.initials: A
authors.lastname: Manke
authors.forename: W
authors.initials: W
authors.lastname: Gowin
authors.forename: G
authors.initials: G
authors.lastname: Mariss
authors.forename: F L
authors.initials: FL
authors.lastname: Welter
mesh_terms: D000328:Adult; D002552:Cerebral Ventricles / Q000473:pathology*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000473:pathology*; D011379:Prognosis; D014910:Wheelchairs
vernacular_title: Die prognostische Bedeutung von lakunären Herden im Magnetischen Resonanztomogramm bei Multipler Sklerose.