[Content of cytochrome P-450 and its induction capacity in primary liver tumors in rats].
The content of cytochrome P-450 has been measured in primary hepatomas induced by diethylnitrosamine. As a rule, the enzyme content in hepatomas was decreased, as compared to normal liver and tumor-affected liver, but some hepatomas contained cytochrome P-450 in greater amount than normal tissue. Aroclor 1254 induced an increase in cytochrome P-450 content, which was identical in hepatomas, normal liver and tumor-affected liver. The dependence of hepatoma morphology on cytochrome P-450 content was not detected.
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D000818:Animals; D001140:Aroclors; D020111:Chlorodiphenyl (54% Chlorine); D003577:Cytochrome P-450 Enzyme System / Q000032:analysis* / Q000096:biosynthesis; D004052:Diethylnitrosamine; D004790:Enzyme Induction / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000032:analysis* / Q000139:chemically induced / Q000201:enzymology; D008862:Microsomes, Liver / Q000032:analysis / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D001140:Aroclors; D020111:Chlorodiphenyl (54% Chlorine); D004052:Diethylnitrosamine; D003577:Cytochrome P-450 Enzyme System
Soderzhanie tsitokhroma P-450 i ego sposobnost' k induktsii v pervichnykh opukholiakh pecheni krys.