[Bacteria, host defense mechanisms and antibiotics].
If immunopharmacological studies of antibiotics have to be done, it urgently involves the development of a better knowledge of the relationships existing between the bacterial virulence factors, the non specific and specific host defense mechanisms and the antibiotics. This will lead to a better and deeper analysis of the antibiotics immune targets at the cellular and molecular levels and will produce and validate new in vivo and ex vivo experimental models, being standardized and closed to clinical setting. These two conditions would permit a better choice of antibiotics in infected patients, taking into account all the factors needed for the recovery.
Lagrange
P H
PH
Laboratoire Central de Microbiologie, Hôtel Dieu, Paris, France.
D000900:Anti-Bacterial Agents / Q000276:immunology* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000472:pathogenicity; D001424:Bacterial Infections / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D014774:Virulence
D000900:Anti-Bacterial Agents
Bactéries, mécanisms de défense de l'hôte et antibiotiques.