Autocrine growth of murine lymphoma cells.
By using an assay system in which small numbers of murine T lymphoma cells are stimulated to grow in serum-free medium, we have continued and expanded our previous studies of an autocrine growth factor that we call leukemia-derived growth factor (LDGF). We show that a T lymphoma cell line of immature phenotype, adapted to growth in serum-free medium, produces and responds to LDGF. LDGF activity is distinct from activities of 10 highly purified or recombinant hematopoietic growth factors including IL-1 and IL-2. However, growth-stimulating activity for the murine lymphoma cells is provided by a partially purified human LDGF.
Hays
E F
EF
Laboratory of Biomedical and Environmental Sciences, Los Angeles, CA 90024.
Kitada
S
S
Uittenbogaart
C H
CH
Reeve
J R
JR
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003470:Culture Media; D006133:Growth Substances / Q000032:analysis* / Q000494:pharmacology; D036341:Intercellular Signaling Peptides and Proteins; D008223:Lymphoma / Q000473:pathology*; D051379:Mice; D014407:Tumor Cells, Cultured / Q000187:drug effects
D003470:Culture Media; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; C047526:leukemia growth-promoting factor