Verapamil and lithium in maintenance therapy of manic patients.
A year-long double-blind cross-over study was used to compare the long-term therapeutic effects of lithium versus verapamil in a group of 20 manic volunteers. Subjects received each medication for six months. Before cross-over, verapamil patients showed a significant improvement after 60 days, lithium-treated patients after 180 days. After cross-over, verapamil-treated subjects showed improvement at day 240. Lithium-treated patients showed no improvement after cross-over. The data indicate that verapamil may be effective as an agent in the maintenance treatment of manic patients.
Giannini
A J
AJ
Ohio State University, Youngstown.
Taraszewski
R
R
Loiselle
R H
RH
D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D008297:Male; D011569:Psychiatric Status Rating Scales; D011897:Random Allocation; D014700:Verapamil / Q000627:therapeutic use*
D008094:Lithium; D014700:Verapamil