title: [Reye's syndrome].
abstract: Reye's syndrome, characterized by acute encephalopathy and fatty degeneration of the viscera with hepatic failure, is a life-threatening illness that affects children of all ages. Although Reye's syndrome has been investigated extensively, its etiology and pathogenesis remain obscure. Metabolic pathophysiology appears to include a process affecting liver mitochondria. Recently disturbances in fatty acid oxidation have been described with a similar clinical picture. The cause of these events is presumably related to triggering viral illnesses, in ways that are unclear. Since prompt treatment might provide a better chance for recovery, early diagnosis is important.
authors.affiliation: Afd. Algemene Intensive Care, Universiteitskliniek voor Kinderen en Jeugdigen, Het Wilhelmina Kinderziekenhuis, Utrecht.
authors.forename: M
authors.initials: M
authors.lastname: Berghuis
authors.forename: A J
authors.initials: AJ
authors.lastname: van Vught
authors.forename: J B
authors.initials: JB
authors.lastname: de Klerk
authors.forename: J
authors.initials: J
authors.lastname: Huber
mesh_terms: D001927:Brain Diseases / Q000503:physiopathology; D002648:Child; D003422:Critical Care / Q000379:methods; D003937:Diagnosis, Differential; D004569:Electroencephalography; D006801:Humans; D007427:Intracranial Pressure; D008661:Metabolism, Inborn Errors / Q000175:diagnosis; D012202:Reye Syndrome / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy
vernacular_title: Het syndroom van Reye.