Mutation frequencies from X-rays, ultraviolet light, and methyl methanesulfonate in Chinese hamster ovary cells incubated with 3-aminobenzamide.
An inhibitor of polyadenosine diphosphoribose polymerase, 3-aminobenzamide, had no effect on survival or mutagenesis in Chinese hamster ovary cells exposed to X-rays or u.v. light. After exposure to methyl methanesulfonate, 3-aminobenzamide increased cell killing and mutagenesis at the 6-thio-guanine-resistance locus, but had no effect on mutagenesis at the ouabain-resistance locus. These results are consistent with the greater role played by polyadenosine diphosphoribose in cells damaged by alkylating agents rather than by radiations.
Guo
X C
XC
Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143.
Cleaver
J E
JE
D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D008741:Methyl Methanesulfonate / Q000494:pharmacology*; D009154:Mutation; D011837:Radiation-Protective Agents / Q000494:pharmacology; D014466:Ultraviolet Rays; D014965:X-Rays
D001549:Benzamides; D011837:Radiation-Protective Agents; C025160:3-aminobenzamide; D008741:Methyl Methanesulfonate