Low-dose neuroleptic therapy for children with childhood-onset pervasive developmental disorder.
An open study of the therapeutic effects of low-dose neuroleptic treatment was performed on 12 consecutively hospitalized children, aged 7-11, who satisfied DSM-III criteria for childhood-onset pervasive developmental disorder. While receiving an average dose of 0.04 mg/kg per day of haloperidol or fluphenazine hydrochloride, the patients exhibited significant reductions in hyperactivity and aggressive symptoms and significant improvement in peer relations. This dose of neuroleptic was associated with minimal side effects. The authors conclude that low doses of potent neuroleptics may be effective treatment for some patients suffering from childhood-onset pervasive developmental disorder.
Joshi
P T
PT
Johns Hopkins Hospital, Baltimore, MD 21205.
Capozzoli
J A
JA
Coyle
J T
JT
D001521:Behavior Therapy; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000188:drug therapy* / Q000523:psychology / Q000628:therapy; D004334:Drug Administration Schedule; D005260:Female; D005476:Fluphenazine / Q000008:administration & dosage* / Q000009:adverse effects; D006220:Haloperidol / Q000008:administration & dosage* / Q000009:adverse effects; D006760:Hospitalization; D006801:Humans; D008297:Male; D008884:Milieu Therapy; D011581:Psychological Tests; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000523:psychology
D006220:Haloperidol; D005476:Fluphenazine