Lack of effect of dihydroergotamine on endothelial and smooth muscle cell proliferation and endothelial cell prostanoid production.
The most important effect of dihydroergotamine is venoconstriction, but certain metabolic effects and changes in vessel prostanoid activity have also been suggested. In this study endothelial cell production of 6-keto PGF1 alpha and TxB2 was quantitated in vitro. No evidence of altered prostanoid production was noted after incubation with dihydroergotamine (exposure ranging from 5 x 10(-3) to 5 x 10(-7) g/l). Similarly, no effect of dihydroergotamine on the growth rates of endothelial cells or smooth muscle cells in vitro was documented.
Lindblad
B
B
Department of Surgery, University of Michigan Medical School, Ann Arbor.
Burkel
W E
WE
Wakefield
T W
TW
Graham
L M
LM
Stanley
J C
JC
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004087:Dihydroergotamine / Q000494:pharmacology*; D004285:Dogs; D004730:Endothelium, Vascular / Q000166:cytology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D011453:Prostaglandins / Q000096:biosynthesis*; D013929:Thromboxane B2 / Q000096:biosynthesis
D011453:Prostaglandins; D004087:Dihydroergotamine; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha