Clinical regression of amyloid nephropathy in a patient with rheumatoid arthritis. A case report.
A 22-year-old woman with active seronegative rheumatoid arthritis responded to intramuscular gold but developed proteinuria which settled when this therapy was stopped. Proteinuria recurred after 2 weeks of penicillamine therapy but settled when this regimen was stopped. Six months later she developed a nephrotic syndrome and rectal and renal biopsies showed evidence of amyloidosis. She was treated with chlorambucil for 1 year and the disease activity was well controlled. There was regression of the nephrotic syndrome and her serum albumin and renal function are normal 6 years later.
Mody
G M
GM
Department of Medicine, University of Cape Town.
Meyers
O L
OL
D000328:Adult; D000686:Amyloidosis / Q000209:etiology*; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy; D002699:Chlorambucil / Q000627:therapeutic use; D005260:Female; D006801:Humans; D009404:Nephrotic Syndrome / Q000209:etiology*; D012074:Remission Induction
D002699:Chlorambucil