title: Retardation of gastric emptying of solid food by secretin.
abstract: The effect of secretin at nearly physiologic plasma concentrations on the gastric emptying rate of solid food was studied in 12 healthy men. A 99mTc colloid-labeled pancake was used as the test meal. The gastric emptying rate was measured during 1 h using a dual-headed gamma-camera, and was expressed as the half-time of the emptying curve. To prevent endogenous secretin release, 400 mg of cimetidine was given before the meal. Subjects were studied under three conditions: (1) during infusion of saline; (2) during continuous infusion of secretin, 6.6 pmol/kg.h; and (3) during three intermittent 10-min periods of secretin infusion, 7.6 pmol/kg.h during each period. Both continuous and intermittent infusion of secretin increased half-emptying time, by 133% and 55%, respectively. The plasma secretin concentration in condition 1 was 0.8 pM; plateau concentration in condition 2 was 9.8 pM; and integrated mean concentration in condition 3 was 4.8 pM. It is concluded that secretin at approximately physiologic plasma concentrations retards gastric emptying of solid food in humans.
authors.affiliation: Department of Gastroenterology, University Hospital, Groningen, the Netherlands.
authors.forename: J H
authors.initials: JH
authors.lastname: Kleibeuker
authors.forename: H
authors.initials: H
authors.lastname: Beekhuis
authors.forename: D A
authors.initials: DA
authors.lastname: Piers
authors.forename: O B
authors.initials: OB
authors.lastname: Schaffalitzky de Muckadell
mesh_terms: D000328:Adult; D002927:Cimetidine / Q000494:pharmacology; D003102:Colloids; D003864:Depression, Chemical; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D012633:Secretin / Q000097:blood / Q000494:pharmacology* / Q000502:physiology; D013667:Technetium; D013997:Time Factors
chemical_list: D003102:Colloids; D012633:Secretin; D013667:Technetium; D002927:Cimetidine