[Systemic arterial pressure and characteristics of its changes in response to hypertensive agents in tumor-bearing animals].
Arterial pressure (in the carotid artery determined by electromanometry) and total peripheral resistance (changes in the clear space of resistive arteries of the mesenterium, skeletal muscles and mammary glands measured by biotelemicroscopy) were studied in tumor-bearing animals (random bred, BALB/c and CBA mice with Ehrlich carcinoma). With the growth of hypodermic injected tumor, it has been shown that the arterial pressure first dropped and then there was a tendency towards normalization, but the pressure never reached the initial level. At the same time arterial dilatation took place, especially at the first stage of tumor growth. This shows the dependence of changes in arterial pressure on the clear space of resistive arteries. It was also revealed that changes in the vascular tone were connected with the functional disturbances of adrenoactive structures but not with reduced myocyte contractility.
Natadze
T G
TG
Kipiani
V A
VA
Kevlishvili
O Sh
OSh
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001158:Arteries; D001794:Blood Pressure / Q000187:drug effects*; D002286:Carcinoma, Ehrlich Tumor / Q000503:physiopathology*; D004837:Epinephrine / Q000494:pharmacology*; D051379:Mice; D009368:Neoplasm Transplantation
D000804:Angiotensin II; D004837:Epinephrine
Sistemnoe arterial'noe davlenie i osobennosti ego izmeneniĭ pri deĭstvii nekotorykh gipertenzivnykh veshchestv u zhivotnykh-opukholenositeleĭ.