Natural antibodies against the carcinoembryonic antigen (CEA) and a related antigen, NCA, in human sera.
Natural antibodies directed against CEA and a related antigen, NCA, have been demonstrated in all normal and pathological sera using an EIA, although they have never been detected by RIA. These antibodies are not anti-blood group antibodies, as their titer was decreased only slightly by absorption with blood group substances. The study of their reactivity with deglycosylated antigens demonstrated that they were directed against peptidic epitopes. Antibodies against NCA or CEA, purified using specific immunosorbents, cross-reacted with all the antigens of the "CEA family" but not or only weakly with unrelated antigens.
Frénoy
N
N
Laboratoire d'Immunochimie, ER 277 CNRS, I.R.S.C, Villejuif, France.
Schauffler
J
J
Cahour
A
A
Burtin
P
P
D000906:Antibodies / Q000276:immunology* / Q000302:isolation & purification; D000951:Antigens, Neoplasm; D001789:Blood Group Antigens / Q000276:immunology; D002272:Carcinoembryonic Antigen / Q000276:immunology*; D015815:Cell Adhesion Molecules; D003429:Cross Reactions; D005455:Fluorescent Antibody Technique; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D011863:Radioimmunoassay
D000906:Antibodies; D000951:Antigens, Neoplasm; D001789:Blood Group Antigens; D002272:Carcinoembryonic Antigen; D015815:Cell Adhesion Molecules; D006023:Glycoproteins; D007140:Immunoglobulin Fab Fragments