title: On the evolution of specificity and catalysis in subtilisin.
authors.affiliation: Department of Biomolecular Chemistry, Genetech Incorporated, South San Francisco, California 94080.
authors.forename: J A
authors.initials: JA
authors.lastname: Wells
authors.forename: B C
authors.initials: BC
authors.lastname: Cunningham
authors.forename: T P
authors.initials: TP
authors.lastname: Graycar
authors.forename: D A
authors.initials: DA
authors.lastname: Estell
authors.forename: P
authors.initials: P
authors.lastname: Carter
mesh_terms: D000595:Amino Acid Sequence; D001407:Bacillus / Q000201:enzymology; D005075:Biological Evolution; D002384:Catalysis; D007700:Kinetics; D008958:Models, Molecular; D011487:Protein Conformation; D012697:Serine Endopeptidases / Q000235:genetics* / Q000378:metabolism; D013045:Species Specificity; D013381:Subtilisins / Q000235:genetics* / Q000378:metabolism
chemical_list: D012697:Serine Endopeptidases; D013381:Subtilisins