Immunohistochemical investigation of topographic localization of phenobarbital and methamphetamine in the rat retina.
The topographic localization of methamphetamine and phenobarbital in the rat retina was studied. It is interesting that the secondary and primary ganglionic cells were stained predominantly only in the case of methamphetamine while in phenobarbital these were not stained. The staining patterns of the inner plexiform layer (strong reaction in phenobarbital and weak reaction in methamphetamine), outer nuclear layer (weak reaction in phenobarbital and strong reaction in methamphetamine) and choroid (very strong reaction in phenobarbital and no reaction in methamphetamine) also showed some differences.
Tanabe
R
R
Department of Forensic Medicine, Faculty of Medicine, University of Tokyo, Japan.
Kaiho
M
M
Yoshii
T
T
Mukaida
M
M
Ishiyama
I
I
D000818:Animals; D008694:Methamphetamine / Q000493:pharmacokinetics*; D010634:Phenobarbital / Q000493:pharmacokinetics*; D051381:Rats; D012160:Retina / Q000032:analysis*
D008694:Methamphetamine; D010634:Phenobarbital