Correlation of the fibrinogen level with blood pressure and plasma renin activity in rats with early Goldblatt hypertension.
Goldblatt hypertension was induced in rats by constricting the renal artery on one side. In one group of animals the contralateral kidney remained untouched (two-kidney hypertension), while in the other it was removed (one-kidney hypertension). In the two-kidney hypertension group, renin activity was higher than in the control animals, the fibrinogen was normal both in arterial and venous blood while in one-kidney hypertension the PRA was normal, but the fibrinogen was increased. A close significant correlation could be demonstrated between blood pressure and fibrinogen.
Sonkodi
S
S
First Department of Medicine, University Medical School, Szeged, Hungary.
Sohár
I
I
Stumpf
E
E
D000818:Animals; D001158:Arteries; D001794:Blood Pressure; D005340:Fibrinogen / Q000378:metabolism*; D006978:Hypertension, Renovascular / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D051381:Rats; D012083:Renin / Q000097:blood*; D014680:Veins
D005340:Fibrinogen; D012083:Renin