title: 2,3-Dihydroxybenzoic acid is a product of human aspirin metabolism.
abstract: 2,3-Dihydroxybenzoic acid is present in blood plasma and urine of healthy human volunteers after aspirin ingestion. Its identity has been confirmed by mass spectrometry and by electrochemical analysis. Methods for its identification and measurement are described. The concentration of 2,3-dihydroxybenzoic acid is much lower than that of 2,5-dihydroxybenzoic acid, salicylic acid or salicyluric acid.
authors.affiliation: Department of Applied Chemistry and Life Sciences, Polytechnic of North London, U.K.
authors.forename: M
authors.initials: M
authors.lastname: Grootveld
authors.forename: B
authors.initials: B
authors.lastname: Halliwell
mesh_terms: D001241:Aspirin / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D005841:Gentisates; D006801:Humans; D062385:Hydroxybenzoates / Q000097:blood* / Q000652:urine; D007700:Kinetics; D013058:Mass Spectrometry
chemical_list: D005841:Gentisates; D062385:Hydroxybenzoates; D001241:Aspirin; C010925:2,5-dihydroxybenzoic acid