NSAID-induced gastric mucosal damage.
Gastric mucosal damage is a common side effect of nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs may cause gastrointestinal symptoms, gastric erosions, peptic ulcers or upper gastrointestinal bleeding. Therefore, NSAIDs should be used cautiously in patients with a history of gastrointestinal lesions. Drugs that may be useful in preventing or treating NSAID-induced gastric mucosal injury are under intensive clinical investigation.
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Bowman Gray School of Medicine, Winston-Salem, North Carolina.
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D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D002908:Chronic Disease; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000175:diagnosis; D005773:Gastroscopy; D006801:Humans; D008297:Male; D010437:Peptic Ulcer / Q000139:chemically induced; D013276:Stomach Ulcer / Q000139:chemically induced / Q000175:diagnosis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin