title: Asbestos exposure-cigarette smoking interactions among shipyard workers.
abstract: We studied the roentgenograms, pulmonary function tests, and physical findings of 294 shipyard workers to evaluate asbestos exposure-cigarette smoking interactions. Roentgenographic parenchymal opacities, decreased pulmonary diffusing capacity for carbon monoxide, decreased flow at low lung volume, rales, and clubbing were each significantly related to the number of years elapsed since first exposure to asbestos and cigarette smoking status when analyzed by logistic regression. A dose-dependent cigarette smoking response that was consistent with synergism was present only for parenchymal opacities and decreased flow at low lung volume. These findings suggest that decreased flow at low lung volume, possibly reflecting peribronchiolar fibrosis, may be a functional corollary to smoking-associated parenchymal roentgenographic opacities among some asbestos-exposed individuals.
authors.affiliation: Robert Wood Johnson Clinical Scholars Program, University of California, San Francisco 94143.
authors.forename: P D
authors.initials: PD
authors.lastname: Blanc
authors.forename: J A
authors.initials: JA
authors.lastname: Golden
authors.forename: G
authors.initials: G
authors.lastname: Gamsu
authors.forename: D R
authors.initials: DR
authors.lastname: Aberle
authors.forename: W M
authors.initials: WM
authors.lastname: Gold
mesh_terms: D001194:Asbestos / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000209:etiology*; D012044:Regression Analysis; D012140:Respiratory Tract Diseases / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D012767:Ships; D012907:Smoking / Q000009:adverse effects*
chemical_list: D001194:Asbestos