Studies on the derivatives of aziridine. II. Synthesis and immunopharmacological analysis of substituted amides and anilides of alpha-aziridinyl-beta-/p-chlorobenzoyl/-propionic acid.
Several new amides and anilides of alpha-aziridinyl-beta-/p-chlorobenzoyl/-propionic acid were synthetized. The beta-/p-chlorobenzoyl/-acrylic acid 2 was used as the substrate. This compound was converted by reaction with appropriate amine into amides and anilides of beta-/p-chlorobenzoyl/-acrylic acid (3-10). These compounds react with ethylenoimine giving appropriate amides and anilides of alpha-aziridinyl-beta-/p-chlorobenzoyl/-propionic acid (11-18). When pharmacologically analyzed, they appeared to possess marked immunotropic activity. The derivatives in question modulated both humoral as well as cellular immune response, the effect being related to the type of substitutent in the amide group.
Zabska
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Department of Chemistry of Drug, Medical Academy, Wrocøaw.
Kowalczyk-Bronisz
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D000818:Animals; D001388:Aziridines / Q000138:chemical synthesis / Q000633:toxicity*; D001389:Azirines / Q000633:toxicity*; D055598:Chemical Phenomena; D002621:Chemistry; D002723:Chlorobenzoates / Q000138:chemical synthesis / Q000633:toxicity; D004487:Edema / Q000276:immunology; D006087:Graft vs Host Reaction / Q000187:drug effects; D006462:Hemolytic Plaque Technique; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007109:Immunity / Q000187:drug effects*; D007928:Lethal Dose 50; D051379:Mice; D008807:Mice, Inbred BALB C; D011422:Propionates / Q000138:chemical synthesis / Q000633:toxicity; D012397:Rosette Formation; D012756:Sheep / Q000276:immunology
D001388:Aziridines; D001389:Azirines; D002723:Chlorobenzoates; D011422:Propionates; C016866:azimexon