title: Comparison of meclofenamate sodium with codeine and placebo for the treatment of episiotomy pain.
abstract: Meclofenamate sodium, a nonsteroidal anti-inflammatory drug with proven analgesic effects, was compared at two dose levels (200 mg and 100 mg) with codeine (60 mg) and placebo in a double-blind, randomized study of 327 women experiencing episiotomy pain after normal delivery. Meclofenamate sodium at either dose was significantly better than codeine or placebo in reducing pain intensity and increasing pain relief, and it had a longer duration of action. Adverse effects were minimal, and their frequency did not differ significantly among treatment groups. Meclofenamate sodium appears to be as safe as and more effective than codeine for the management of episiotomy pain.
authors.affiliation: Stormont-Vail Hospital, Topeka, Kansas.
authors.forename: J A
authors.initials: JA
authors.lastname: Gleason
authors.forename: W
authors.initials: W
authors.lastname: Winer
authors.forename: J L
authors.initials: JL
authors.lastname: Turner
mesh_terms: D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D003061:Codeine / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004341:Drug Evaluation; D004841:Episiotomy; D005260:Female; D006801:Humans; D008469:Meclofenamic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D062367:ortho-Aminobenzoates / Q000627:therapeutic use*
chemical_list: D062367:ortho-Aminobenzoates; D008469:Meclofenamic Acid; D003061:Codeine