[Two-route chemotherapy by CDDP and STS in liver metastasis of gastrointestinal adenocarcinoma].
Nine (six male and three female) patients with unresectable liver metastasis of gastrointestinal adenocarcinoma were treated by two-route chemotherapy using cis-diamminedichloroplatinum (CDDP) and sodium thiosulfate (STS). Of the nine patients, two had colon cancer, three had stomach cancer and the remaining four gall bladder cancer. In these patients, 100 mg/body of CDDP was administered through the common hepatic artery by the balloon-occluded arterial infusion (B.O.A.I.) method, and just after administration, intravenous infusion of STS (10 g/body) was given. The treatment was repeated at intervals of six to 12 weeks, and the following results were obtained: 1) Seven patients of the nine were eligible for evaluation of response to the treatment. Of the seven cases, partial response (PR) was recorded in two cases, and no change (NC) in five. The response rate in eligible cases was about 30%. 2) Though all the patients suffered nausea and vomiting to a mild degree after the treatment, none of the patients showed significant side effects potentially limiting the dose, such as bone marrow suppression and/or renal failure. In conclusion, this study demonstrated the efficacy of CDDP for liver metastasis of gastrointestinal adenocarcinoma, and the protective effects of STS against the toxicity of CDDP were well indicated, in spite of the low number of cases examined.
Nojiri
O
O
Dept. of Internal Medicine, City of Toyakawa Hospital.
Nakamura
M
M
Tanaka
Y
Y
Banno
T
T
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000368:Aged; D002945:Cisplatin / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005770:Gastrointestinal Neoplasms; D006801:Humans; D007262:Infusions, Intravenous; D007269:Injections, Intra-Arterial; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D013885:Thiosulfates / Q000008:administration & dosage*
D013885:Thiosulfates; C017717:sodium thiosulfate; D002945:Cisplatin