title: Proliferative activity of rectal mucosa and soluble fecal bile acids in patients with normal colons and in patients with colonic polyps or cancer.
abstract: Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous history of colon cancer) and 7 were diagnosed with colon cancer. In confirmation of earlier studies the tritiated thymidine labelling index was higher in patients with tumors than in those without pathology (7.9% vs. 5.8% with P = 0.06). The patients with colonic tumors also had significantly higher levels of deoxycholic acid (P = 0.01) and lithocholic acid (P = 0.005) in the aqueous extract of their feces. This study shows that these biochemical measures may indicate colon cancer risk.
authors.affiliation: Ludwig Institute for Cancer Research, Toronto Branch, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Stadler
authors.forename: K S
authors.initials: KS
authors.lastname: Yeung
authors.forename: R
authors.initials: R
authors.lastname: Furrer
authors.forename: N
authors.initials: N
authors.lastname: Marcon
authors.forename: H S
authors.initials: HS
authors.lastname: Himal
authors.forename: W R
authors.initials: WR
authors.lastname: Bruce
mesh_terms: D001647:Bile Acids and Salts / Q000032:analysis*; D002455:Cell Division; D003110:Colonic Neoplasms / Q000032:analysis* / Q000473:pathology; D003111:Colonic Polyps / Q000032:analysis* / Q000473:pathology; D005243:Feces / Q000032:analysis*; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D012007:Rectum / Q000473:pathology*
chemical_list: D001647:Bile Acids and Salts