title: Tilt suppression of vestibulo-ocular reflex in patients with cerebellar lesions.
abstract: The effect of tilt on the time constant of post-rotatory nystagmus was determined in a group of normal subjects and patients with cerebellar lesions. The normal subjects showed a vestibular response that decayed with a time constant of 19.6 s when upright and 7.2 s after tilt prone. Patients with midline cerebellar lesions near the uvula and nodulus had time constants that were normal in the upright position but were unaffected by head tilt. Patients with cerebellar lesions due to the Arnold-Chiari malformation showed behavior that was intermediate between that of normal subjects and the patients with midline lesions. These results provide evidence that in humans, the midline cerebellum regulates a neural network in the brainstem that perseverates peripheral vestibular input.
authors.affiliation: Department of Neurology, Johns Hopkins Hospital School of Medicine, Baltimore, Maryland 21205.
authors.forename: T C
authors.initials: TC
authors.lastname: Hain
authors.forename: D S
authors.initials: DS
authors.lastname: Zee
authors.forename: B L
authors.initials: BL
authors.lastname: Maria
mesh_terms: D000293:Adolescent; D000328:Adult; D001139:Arnold-Chiari Malformation / Q000503:physiopathology*; D002528:Cerebellar Neoplasms / Q000503:physiopathology*; D002531:Cerebellum / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009760:Nystagmus, Physiologic; D011187:Posture; D012027:Reflex, Vestibulo-Ocular; D013997:Time Factors