title: Aqueous humor penetration of ciprofloxacin in the human eye.
abstract: Two doses of ciprofloxacin were administered intravenously, 200 mg every 12 hours, to 25 patients undergoing cataract surgery. Plasma and aqueous humor were obtained at 1, 3, 5, 7, and 9 hours after the administration of the second dose of the drug. Peak intraocular concentrations (mean +/- SD), 0.21 +/- 0.1 mg/L, were detected at one hour following ciprofloxacin administration. A time-dependent decrease of the penetration was observed, and by nine hours after the administration, ciprofloxacin levels were 0.05 mg/L. These results illustrate that ciprofloxacin may be an effective antimicrobial agent for prophylactic use in ophthalmologic surgery and also for the treatment of intraocular infections due to susceptible organisms.
authors.affiliation: Department of Medicine, University of Patras, Greece.
authors.forename: A T
authors.initials: AT
authors.lastname: Skoutelis
authors.forename: S P
authors.initials: SP
authors.lastname: Gartaganis
authors.forename: C J
authors.initials: CJ
authors.lastname: Chrysanthopoulos
authors.forename: D
authors.initials: D
authors.lastname: Beermann
authors.forename: C
authors.initials: C
authors.lastname: Papachristou
authors.forename: H P
authors.initials: HP
authors.lastname: Bassaris
mesh_terms: D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D002939:Ciprofloxacin / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D013997:Time Factors
chemical_list: D002939:Ciprofloxacin