Common characteristics of primary cell cultures originated from invasive urothelial carcinoma.
Ten primary cultures from invasive urothelial carcinomas were studied by light and electron microscopy. In all cultures, cells with accumulations of glycosaminoglycans were observed. Long membrane extensions with accumulations of glycosaminoglycans invaded neighboring cells and formed an extracellular matrix as well. The extracellular matrix inhibited cell proliferation and enhanced tumor nodule formation.
Logothetou-Rella
H
H
Department of Experimental Physiology, University of Athens Medical School, Greece.
Nesland
J M
JM
Vamvassakis
E
E
Karayiannis
A
A
Hadjiminas
J
J
Dimopoulos
C
C
D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D005109:Extracellular Matrix / Q000648:ultrastructure; D006025:Glycosaminoglycans / Q000032:analysis; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D014407:Tumor Cells, Cultured / Q000473:pathology
D006025:Glycosaminoglycans