[Pregnancy toxemia. Review and management].
The author reviews the literature on pre-eclamptic toxaemia, and seeks to ascertain established pathophysiological facts. He points out that the diversity of names used by different authors and in different countries all cover a specific pathological entity, in pregnancy in the human. He looks at causes that may be considered specifically human: the upright position with consequences for the blood circulation, food eaten without regard to the woman's needs, stress factors due to the environment and also to imagination. He considers the relationship between the trophoblast and the maternal body which is specific to pregnancy. From these considerations he describes a synthesis of pathophysiological conditions which give to this specific human disease of pregnancy: One cause: the presence of trophoblasts. Two centres of activity: intravenous disseminated coagulation and platelet activity. Three syndromes: haemodynamic, vascular and renal. Four cardinal signs: albuminuria, raised blood pressure, oedema, hyperuricaemia. Five areas to which prophylaxis, prevention and treatment can be directed: hypovolaemia, hypoalbuminaemia, vasoconstriction, platelet activity, presence of trophoblastic tissue. He suggests a possible sequence for prophylaxis, prevention and treatment to be worked out from these features.
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Becquerel, Perpignan.
D005260:Female; D006801:Humans; D011225:Pre-Eclampsia; D011247:Pregnancy
La maladie gravidique. Essai de synthèse et conduite à tenir.