title: The disposition of bunolol in the rabbit eye.
abstract: Following topical administration to albino rabbits, bunolol hydrochloride, a beta 1- and beta 2-adrenoceptor antagonist, was rapidly absorbed and distributed in ocular tissues, and transformed intraocularly to a single metabolite, dihydrobunolol. The half-life of bunolol was approximately 1.26 hours in the aqueous humor and 1.63 hours in the ciliary body. There was no significant accumulation of bunolol during a four-day period of twice-daily dosing. Most of the drug was excreted in the urine following ocular or intravenous administration.
authors.affiliation: Research and Development, Allergan Inc., Irvine, California.
authors.forename: C C
authors.initials: CC
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Anderson
authors.forename: M
authors.initials: M
authors.lastname: Shackleton
authors.forename: J
authors.initials: J
authors.lastname: Attard
mesh_terms: D000042:Absorption; D000287:Administration, Topical; D000818:Animals; D001711:Biotransformation; D005123:Eye / Q000378:metabolism*; D005260:Female; D002040:Levobunolol / Q000493:pharmacokinetics* / Q000652:urine; D011817:Rabbits; D014018:Tissue Distribution
chemical_list: D002040:Levobunolol