The dorsal skin-fold preparation of awake Syrian golden hamsters for assessment of microvascular permeability and microhaemodynamics with leukotriene C4.
This study has quantitated the effects of topically-applied leukotriene C4 (LTC4) upon vessel diameters, red blood cell velocities and vascular permeability to macromolecules in an animal model, namely, the dorsal skin-fold preparation of Syrian golden hamsters. Furthermore, we studied the efficacy of the leukotriene receptor blocking agent FPL 55712 in this preparation in order to establish a model for testing antiinflammatory compounds possibly involved in the lipoxygenase cascade.
Conzen
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Institute of Surgical Research, Ludwig Maximilians University, Munich, Federal Republic of Germany.
Goetz
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AE
Deininger
F
F
Brendel
W
W
D000818:Animals; D001776:Blood Circulation Time; D001808:Blood Vessels / Q000033:anatomy & histology; D002199:Capillary Permeability / Q000187:drug effects*; D003243:Consciousness; D006224:Cricetinae; D004864:Equipment and Supplies; D006439:Hemodynamics / Q000187:drug effects*; D008647:Mesocricetus; D013189:SRS-A / Q000494:pharmacology*; D012884:Skin Window Technique
D013189:SRS-A