Effects of hormone treatment on chromosomal radiosensitivity of somatic and germ cells of Snell's dwarf mice.
The X-ray induction of micronuclei and structural chromosomal aberrations was studied in bone-marrow cells of normal and dwarf (dw) mice in combination with thyroxine and/or prolactin treatment or otherwise. Hormone treatment clearly increased micronuclei induction but not chromosome breakage, suggesting that indirect effects were involved. Since no clear differences in the timing of the final stage of erythropoiesis could be found, it is likely that the indirect effects are mediated via the formation-differentiation kinetics of erythroblasts. The induction of reciprocal translocations by X-rays in stem cell spermatogonia of dwarf mice was lower than in normals and treatment with prolactin, growth hormone and/or thyroxin, did not influence the chromosomal radiosensitivity of spermatogonial stem cells.
van Buul
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Department of Radiation Genetics and Chemical Mutagenesis, J.A. Cohen Institute, Sylvius Laboratories, Leiden, The Netherlands.
van Buul-Offers
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SC
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000528:radiation effects*; D002869:Chromosome Aberrations; D004393:Dwarfism, Pituitary / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D004920:Erythropoiesis / Q000187:drug effects / Q000528:radiation effects*; D013006:Growth Hormone / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics / Q000502:physiology*; D011388:Prolactin / Q000494:pharmacology* / Q000627:therapeutic use; D011836:Radiation Tolerance / Q000187:drug effects; D013093:Spermatogonia / Q000187:drug effects / Q000528:radiation effects; D013974:Thyroxine / Q000494:pharmacology / Q000627:therapeutic use; D014178:Translocation, Genetic
D011388:Prolactin; D013006:Growth Hormone; D013974:Thyroxine