Haemodynamic and renal effects of a novel prostaglandin analogue (L644,122(+isomer)) in sheep.
1. Merino-cross ewes were given an intravenous injection of a prostaglandin analogue, (+)-4-(3-[3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]- propyl) benzoic acid, at doses of 0.01, 0.05 and 0.10 mg/kg, on separate days, to determine renal and haemodynamic responses. 2. Peripheral vasodilatory effects, indicated by increases in heart rate and cardiac output, and falls in total peripheral resistance, peaked at 20 min at the two highest doses. By 60 min most values had returned to pre-injection levels. There were no changes in mean arterial pressure. 3. At the highest dose of 0.10 mg/kg there was a fall in glomerular filtration rate, renal blood flow and effective renal plasma flow within 20 min. Urinary sodium and potassium excretion also fell with all three doses tested. 4. Plasma renin concentration increased at the 0.05 and 0.10 mg/kg doses and was still elevated at 60 min. 5. The results of this study in the sheep contrast with others in the dog, where renal blood flow is increased and the rat, where blood pressure is increased, and indicate a species specificity in regard to the analogue's actions.
Tresham
J J
JJ
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Vic. Australia.
Whitworth
J A
JA
Scoggins
B A
BA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects*; D012079:Renal Circulation / Q000187:drug effects; D012083:Renin / Q000097:blood; D012756:Sheep; D013844:Thiazoles / Q000494:pharmacology*; D053778:Thiazolidines; D014665:Vasodilator Agents / Q000494:pharmacology*
D013844:Thiazoles; D053778:Thiazolidines; D014665:Vasodilator Agents; C035264:4-(3-((2-(1-hydroxycyclohexyl)ethyl)-4-oxo-2-thiazolidinyl)propyl)benzoic acid; D012083:Renin