Electrically elicited blink reflex and early acoustic evoked potentials in circumscribed and diffuse brain stem lesions.
In the present paper, the function of the brain stem in patients with brain stem lesions of various aetiology is investigated with electrophysiological methods. The clinical observations are supplemented by experimental investigations on cats, in which the blink reflex and the early acoustic evoked potentials were registered during the acute elevation of intracranial pressure. The findings in patients with circumscribed space-occupying lesions in the posterior fossa document that the registration of the BR and the BAEP have a functional diagnostic significance above and beyond the neurological and radiological investigation. In the case of the cerebellar space occupations, specific alterations could not be observed. On the contrary, the alterations of BR and BAEP indicate a general disturbance of brain stem function, possibly as a result of a general increase of intracranial pressure. In cerebellopontine angle tumours, both BR and BAEP showed specific alterations which were usually asymmetrical. The BR changes ipsilateral to the tumour are of major topodiagnostic significance, whereas the alterations of the contralateral potential are especially informative in the registration of BAEP. The alterations of BR and BAEP also allow an appraisal of the localization and extent of the lesion in primary space occupations in the brain stem: A pathological R1 indicates a pontine lesion, whereas pathological R2 responses are found in medullary and in oral pontine and mesencephalic lesions. In contrast to cerebellopontine angle tumours, the BAEP tends to show symmetrical alterations in primary brain stem lesions. The prolongations of interpeak latencies correspond to the brain stem segment concerned, and the same also applies to pathological amplitude reduction and deformations of individual potentials. In patients with localized brain stem damage, the reflex pathway of R2 is discussed on the basis of the BR findings. In contrast to the view held up to now that only structures situated caudal of the facial nucleus area are responsible for the genesis of the R2 response, it is assumed on the basis of our own observations that pontomesencephalic structures rostral to the facial nuclei are also important for the genesis of R2. Registration of BR and BAEP in patients with acute diffuse brain stem damage shows that both methods have a high diagnostic and prognostic value. Isolated damage and combined brain stem lesion can be demonstrated and the course can be followed up. Normalization of pathological findings reflects clinical recovery, and conversely a secondary deterioration indicates the presence of complications.(ABSTRACT TRUNCATED AT 400 WORDS)
Klug
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N
Department of Neurosurgery, University of Giessen, Federal Republic of Germany.
Csécsei
G
G
D000328:Adult; D000818:Animals; D001767:Blinking; D001926:Brain Death; D001927:Brain Diseases / Q000473:pathology / Q000503:physiopathology; D001932:Brain Neoplasms / Q000503:physiopathology; D001933:Brain Stem / Q000503:physiopathology; D004558:Electric Stimulation; D005072:Evoked Potentials, Auditory; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis