Anonymous and non-anonymous oocyte donation preliminary results.
During the past year, we have developed an oocyte donation programme in 10 patients with complete absence of endogenous ovarian function (premature ovarian failure in seven cases, castration in two cases and Turner's syndrome in one case). In cases of anonymous donation, donors were volunteers devoid of any major genetical risk who were included in our IVF programme and who consented to donate one oocyte when at least seven oocytes were recovered, and two oocytes when at least 11 oocytes were recovered, to a recipient couple. As far as possible, morphological characteristics of both couples were paired. In cases of non-anonymous donation, donors were 'affective' donors, having at least one child. The resulting embryos after IVF of donated oocytes were either replaced directly in recipient women which required synchronization of the donor's and recipient's cycles, or cryopreserved and then thawed, usually at day 16 of recipient's artificial cycle, i.e. 2 days after introduction of the progestational compound. On the 10 patients entering this oocyte donation programme (20 cycles), 13 transfers were carried out resulting in four clinical pregnancies in three patients with premature ovarian failure and one with Turner's syndrome (20% pregnancy per cycle and 31% per transfer). Despite the small numbers, these good results prompted us to develop this protocol.
Junca
A M
AM
Clinique Marignan, Paris, France.
Cohen
J
J
Mandelbaum
J
J
Alnot
M O
MO
Debache
C
C
Plachot
M
M
Pez
J P
JP
D000328:Adult; D004359:Drug Therapy, Combination; D004624:Embryo Transfer; D004958:Estradiol / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D009865:Oocytes; D010053:Ovary / Q000502:physiology; D011247:Pregnancy; D011255:Pregnancy Maintenance; D011374:Progesterone / Q000627:therapeutic use; D014019:Tissue Donors
D011374:Progesterone; D004958:Estradiol