Lymphocyte activation in oral lichen planus in situ.
The current study evaluated the activation of T-cell mediated cellular immune response in the oral lesions in lichen planus (OLP). Analysis was made of the ultramorphology, lymphocyte activation marker expression, DNA synthesis, and gamma-interferon production of the inflammatory cells in OLP lesions. According to these four different aspects of lymphocyte activation, only a minor fraction, 5% at the most, of all T-cells in situ were activated. This minor fraction, however, not the resting T-cells without these signs of activation, may decide the outcome of the local immune-inflammatory process in OLP. Of the inflammatory cells in situ, however, 81 +/- 5% were Ia positive. This finding may be the result of an Ia inducing capacity of the gamma-interferon produced locally by the activated T-cells.
Malmström
M
M
Department of Oral and Maxillofacial Surgery, Helsinki University, Finland.
Konttinen
Y T
YT
Jungell
P
P
Bergroth
V
V
Segerberg-Konttinen
M
M
Nordström
D
D
D000954:Antigens, Surface / Q000032:analysis; D001345:Autoradiography; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D008010:Lichen Planus / Q000473:pathology*; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000096:biosynthesis; D008297:Male; D008854:Microscopy, Electron; D009059:Mouth Diseases / Q000473:pathology*; D010641:Phenotype
D000954:Antigens, Surface; D007136:Immunoglobulins; D008222:Lymphokines