title: Determination of the time of closure of the ductus arteriosus in severely ill premature infants.
abstract: In order to investigate the time of ductal closure in the premature infant, we performed multiple echocardiographic examination in each of 42 premature infants. Twenty eight of these infants had spontaneous closure of the ductus arteriosus (median date of closure--3 days). Twelve required medical or surgical closure of the ductus arteriosus and two died of severe lung disease. There was a significant relationship of decreasing birth weight to prolonged patency of the ductus arteriosus.
authors.affiliation: Department of Pediatrics, Bowman Gray School of Medicine, Winston-Salem, NC 27103.
authors.forename: R C
authors.initials: RC
authors.lastname: McKone
authors.forename: K M
authors.initials: KM
authors.lastname: Weesner
mesh_terms: D004373:Ductus Arteriosus / Q000503:physiopathology* / Q000601:surgery; D004374:Ductus Arteriosus, Patent / Q000503:physiopathology* / Q000601:surgery; D004452:Echocardiography; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011379:Prognosis; D011897:Random Allocation; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications; D013995:Time; D013997:Time Factors