title: Patients with CLL and hypocomplementaemia have an impaired serum bactericidal activity against the Salmonella minnesota Re mutant.
abstract: The bactericidal effect of 25 serum samples from 23 patients with chronic lymphocytic leukaemia (CLL) against the Salmonella minnesota S form and Re mutant has been studied. No killing of the S form was observed in any of the sera tested, whereas a normal bactericidal effect was found against the Re mutant (group 1) in 17/25 sera of CLL patients. By contrast, in 8 serum samples from 6 CLL patients no killing or a markedly delayed killing of the Re strain was observed (group 2). Significant differences in the complement levels were found between the sera of group 1 and group 2. In group 1 mostly normal or elevated complement levels were observed, while in group 2 levels of C4 and C2 were found to be strongly decreased. A significant correlation was found between the bactericidal effect on the one hand and the C4 and C2 levels on the other.
authors.affiliation: National Institute of Haematology and Blood Transfusion, Budapest, Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Varga
authors.forename: F
authors.initials: F
authors.lastname: Clas
authors.forename: G
authors.initials: G
authors.lastname: Füst
authors.forename: K
authors.initials: K
authors.lastname: Pálóczi
authors.forename: G
authors.initials: G
authors.lastname: Szegedi
authors.forename: M
authors.initials: M
authors.lastname: Loos
authors.forename: S R
authors.initials: SR
authors.lastname: Hollán
mesh_terms: D001770:Blood Bactericidal Activity; D003175:Complement C2 / Q000172:deficiency; D003181:Complement C4 / Q000172:deficiency; D003165:Complement System Proteins / Q000172:deficiency*; D004198:Disease Susceptibility; D005260:Female; D007945:Leukemia, Lymphoid / Q000097:blood* / Q000276:immunology; D008297:Male; D012475:Salmonella / Q000235:genetics*
chemical_list: D003175:Complement C2; D003181:Complement C4; D003165:Complement System Proteins