title: Clinical and pathological evolution of alpha chain disease to immunoblastic lymphoma and response to COMP chemotherapy.
abstract: A small adolescent with alpha heavy chain disease presenting as malabsorption and evolving to immunoblastic lymphoma is reported. The pathological evolution is documented by serial endoscopy and small intestinal biopsy. Clinical and pathological remission was obtained by the use of COMP combination chemotherapy.
authors.affiliation: Department of Paediatrics and Child Health, University of Cape Town, South Africa.
authors.forename: P
authors.initials: P
authors.lastname: Rogers
authors.forename: I
authors.initials: I
authors.lastname: Hill
authors.forename: C
authors.initials: C
authors.lastname: Sinclair-Smith
authors.forename: M
authors.initials: M
authors.lastname: Bowie
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D007161:Immunoproliferative Small Intestinal Disease / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone; D008727:Methotrexate