title: Effect of low doses of whole body irradiation on spontaneous lung metastasis of NFSA2ALM1 mouse tumors.
abstract: The effect of low-dose (10-50 cGy) irradiation, delivered as single or fractionated doses, on metastatic development was investigated using NFSA2ALM1 fibrosarcoma and the C3H/HeNrs mouse. Spontaneous lung metastases from tumors transplanted into the leg were suppressed in those mice irradiated with low doses of radiation 12 days after tumor cell inoculation. Abbreviations used: LCFE = lung colony forming efficiency through i.v. injection of tumor cells; SLME = spontaneous lung metastasis efficiency from leg tumors; TD50 = cell number which produces tumors in 50% of inoculated sites; WBI = Whole body irradiation.
authors.affiliation: Department of Radiation Oncology, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Mizukoshi
mesh_terms: D000818:Animals; D005354:Fibrosarcoma / Q000532:radiotherapy* / Q000556:secondary; D008175:Lung Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011879:Radiotherapy Dosage; D014916:Whole-Body Irradiation