The influence of thymus hormones on the NK cells activity.
The influence of thymus hormone preparations on NK cell activity was studied. The following preparations were used: crude extract from calf thymus (TFX), its fraction V (TFX V) and synthetic pentapeptide (TP-5) fragment of native hemopoietin. It was shown that all preparations under study activate NK cells in vitro. The weakest effect was observed in the case of TFX, while both TFX V and TP-5 showed equally good stimulatory properties. The obtained results are discussed. The weak effect of the crude TFX is probably caused by the fact that it contains only 15% of fraction V which is responsible for affinity to the immune system.
Giełdanowski
J
J
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Lemmel
E M
EM
Błaszczyk
B
B
D002460:Cell Line; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology; D010446:Peptide Fragments / Q000494:pharmacology; D016305:Thymopentin; D013946:Thymopoietins / Q000494:pharmacology; D013949:Thymus Extracts / Q000494:pharmacology; D013951:Thymus Hormones / Q000494:pharmacology / Q000502:physiology*
D010446:Peptide Fragments; C019108:TFX; D013946:Thymopoietins; D013949:Thymus Extracts; D013951:Thymus Hormones; D016305:Thymopentin