title: Sodium fluoride and chromosome damage (in vitro human lymphocyte and in vivo micronucleus assays).
abstract: The clastogenic potential of sodium fluoride was determined both in vitro (using cultured human lymphocytes) and in vivo (using the rat bone-marrow micronucleus test). The incidence of chromosome aberrations in human lymphocyte cultures exposed to 20 or 40 micrograms/ml sodium fluoride (3 and 9% respectively) was significantly increased compared with control cultures (0.5%). However, the incidence of micronucleated polychromatic erythrocytes in male AP rats dosed 1000 mg/kg NaF (the maximum tolerated dose over 24 h) or 500 mg/kg NaF was similar to that in the animals dosed distilled water (vehicle control). Thus, sodium fluoride is clastogenic in vitro but not in vivo.
authors.affiliation: ICI Pharmaceuticals Division, Macclesfield, Cheshire, UK.
authors.forename: R
authors.initials: R
authors.lastname: Albanese
mesh_terms: D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects*; D003520:Cyclophosphamide / Q000633:toxicity; D006801:Humans; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects; D009153:Mutagens; D012969:Sodium Fluoride / Q000633:toxicity*
chemical_list: D009153:Mutagens; D003520:Cyclophosphamide; D012969:Sodium Fluoride