title: Pharmacological modulation of cold-induced pain in cutaneous leiomyomata.
abstract: In two patients with painful cutaneous leiomyomata, induction of pain by the application of an ice cube allowed assessment of a number of topical and systemic treatments aimed at reducing or preventing the pain. In one patient the alpha-adrenoceptor blocker, phenoxybenzamine alleviated cold-induced pain. In the second patient, topical 9% hyoscine hydrobromide (an anticholinergic agent) decreased pain induced by the ice cube, but was not helpful in reducing lesional pain due to cold weather.
authors.affiliation: St John's Hospital for Diseases of the Skin, Leicester Square, London, U.K.
authors.forename: C B
authors.initials: CB
authors.lastname: Archer
authors.forename: S
authors.initials: S
authors.lastname: Whittaker
authors.forename: M W
authors.initials: MW
authors.lastname: Greaves
mesh_terms: D000328:Adult; D003080:Cold Temperature / Q000009:adverse effects; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010643:Phenoxybenzamine / Q000627:therapeutic use; D012601:Scopolamine / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000503:physiopathology*
chemical_list: D010643:Phenoxybenzamine; D012601:Scopolamine