title: When asleep, one is cooler on beta-blockade than on placebo. A study of pulmonary arterial blood temperature and skeletal muscle heat production in anaesthetized man.
abstract: The effect of beta 1-adrenergic blockade on body temperature was studied during general anaesthesia by means of a thermistor in an indwelling pulmonary arterial catheter. Metoprolol (200 mg daily) or placebo was given double-blind preoperatively for at least 2 weeks to 27 hypertensive patients undergoing abdominal surgery. A significantly greater temperature fall was observed in the metoprolol group compared with the placebo group. Heat production in the rectus abdominis muscle, measured by direct microcalorimetry, was significantly lower after metoprolol. The hypothermic effect of beta-adrenergic blockade during anaesthesia deserves special attention.
authors.affiliation: Department of Internal Medicine, University Hospital, Lund, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Fagher
authors.forename: J
authors.initials: J
authors.lastname: Magnússon
authors.forename: M
authors.initials: M
authors.lastname: Monti
authors.forename: T
authors.initials: T
authors.lastname: Thulin
authors.forename: O
authors.initials: O
authors.lastname: Werner
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001769:Blood / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000494:pharmacology*; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects*; D011897:Random Allocation
chemical_list: D008790:Metoprolol