Hydrocortisone differentially alters lesion-induced axon sprouting in male and female rats.
Hydrocortisone was administered to young adult male or female rats after removal of the entorhinal cortex. Lesion-induced outgrowth of the commissural-associational afferent fibers in the hippocampus was quantitated. The glucocorticoids caused a significant decline in axon sprouting in the male subjects and a significant increase in outgrowth in female subjects. Depending on the sex, the hormonal effects on lesion-induced axonal growth are markedly different in the rat.
Scheff
S W
SW
Department of Anatomy, Sanders-Brown Research Center on Aging, University of Kentucky, Lexington.
Morse
J K
JK
DeKosky
S T
ST
D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000502:physiology; D001927:Brain Diseases / Q000503:physiopathology*; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000254:growth & development*; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D006854:Hydrocortisone