Cerebral hypoxia-ischemia in immature rats: methodological considerations.
We used a model of perinatal hypoxic/ischemic brain damage which combines unilateral common carotid artery ligation and hypoxia (8% O2). Protein synthesis inhibition and cell loss were found in the ipsilateral forebrain of 11-day-old rats when hypoxia was initiated 4 h but not 24 h after carotid ligation. [14C]Iodoantipyrine uptake studies suggest that compensating vascular changes which protect the ipsilateral forebrain occur within 24 h of carotid ligation.
Dwyer
B E
BE
Epilepsy Research Laboratory, Veterans Administration Medical Center, Sepulveda, California 91343.
Nishimura
R N
RN
Fujikawa
D G
DG
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D002534:Hypoxia, Brain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains