Histochemical and immunohistochemical study of noradrenergic, serotonergic and peptidergic innervation of the cerebral circulation.
Using fluorescence histochemistry, we have examined the origin of noradrenaline (NA)-, 5-hydroxytryptamine (5-HT)- and neuropeptide Y (NPY)-containing perivascular nerve fibres supplying the major cerebral arteries of the gerbil, and the effect of superior cervical ganglionectomy on their cerebrovascular density and distribution. Bilateral ganglionectomy resulted in a complete loss of these perivascular nerve types in the anterior circulation, while a few fibres still persisted in the posterior circulatory bed. In addition, we demonstrate the presence of both 5-HT- and NPY-positive cell bodies in the superior cervical ganglion (SCG) of adult gerbils, suggesting that the main origin of cerebrovascular 5-HT- and NPY- (as well as NA-) containing nerve fibres is in the SCG.
Alafaci
C
C
Department of Anatomy and Developmental Biology, University College London, United Kingdom.
Tomasello
F
F
Burnstock
G
G
D000818:Animals; D001808:Blood Vessels / Q000294:innervation; D002560:Cerebrovascular Circulation; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D007150:Immunohistochemistry; D009412:Nerve Fibers / Q000033:anatomy & histology / Q000378:metabolism* / Q000502:physiology; D009478:Neuropeptide Y / Q000378:metabolism / Q000502:physiology*; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*; D013562:Sympathectomy
D009478:Neuropeptide Y; D012701:Serotonin; D009638:Norepinephrine