title: Evidence for a novel gene associated with low tumor metastatic potential.
abstract: We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identified, and (2) N-nitroso-N-methylurea-induced rat mammary carcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsic aggressiveness. The predicted carboxy-terminal protein sequence encoded by the pNM23 cDNA clone is novel compared with Genebank animal, bacterial, and viral sequences.
authors.affiliation: Division of Cancer Biology and Diagnosis, National Cancer Institute, Bethesda, MD 20892.
authors.forename: P S
authors.initials: PS
authors.lastname: Steeg
authors.forename: G
authors.initials: G
authors.lastname: Bevilacqua
authors.forename: L
authors.initials: L
authors.lastname: Kopper
authors.forename: U P
authors.initials: UP
authors.lastname: Thorgeirsson
authors.forename: J E
authors.initials: JE
authors.lastname: Talmadge
authors.forename: L A
authors.initials: LA
authors.lastname: Liotta
authors.forename: M E
authors.initials: ME
authors.lastname: Sobel
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005796:Genes; D008325:Mammary Neoplasms, Experimental / Q000235:genetics* / Q000473:pathology; D008546:Melanoma, Experimental / Q000235:genetics* / Q000473:pathology; D051379:Mice; D008969:Molecular Sequence Data; D009362:Neoplasm Metastasis
chemical_list: D004273:DNA, Neoplasm