title: Merkel cell carcinoma: a review of behaviour patterns and management strategies.
abstract: Eleven patients with Merkel cell carcinoma of the skin were reviewed retrospectively. The aggressive nature of this tumour is reflected by the incidence of local recurrence, regional nodal metastases and systemic dissemination, which is 36%, 55%, and 18% respectively. This high frequency of local recurrence and metastases is confirmed in the literature. Management strategies should be planned accordingly, following accurate assessment of the extent of disease. Wide excision, with or without nodal dissection, together with adjuvant wide field irradiation is necessary for loco-regional control of this radiosensitive tumour. Radiotherapy alone may be appropriate treatment for extensive loco-regional tumours or in those that have already metastasized. Although the role of chemotherapy is unclear, there are an increasing number of reports of chemosensitivity and further investigation in this area is required.
authors.affiliation: Radiotherapy Department Royal Adelaide Hospital, North Terrace, South Australia.
authors.forename: P C
authors.initials: PC
authors.lastname: O'Brien
authors.forename: J W
authors.initials: JW
authors.lastname: Denham
authors.forename: A S
authors.initials: AS
authors.lastname: Leong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002610:Cheek / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery