Treatment of retinoblastoma. Results obtained from a prospective study of 51 patients.
During 4 years, 51 patients with retinoblastoma were studied (unilateral 32, and bilateral 19). Treatment consisted of enucleation of those eyes which showed massive involvement followed by radiotherapy when there was optic nerve and/or orbit involvement. Systemic chemotherapy was administered to all patients who underwent nonsurgical treatment and when the histologic examination showed choroidal optic nerve head and/or optic nerve involvement or residual tumor after enucleation. When there was compromise of the central nervous system intrathecal chemotherapy was administered. Nonsurgical treatment consisted of radiotherapy and/or light coagulation. Survival was 90.6% for unilateral cases and 84.2% for the bilateral. The median follow-up was 31 months and 29 months, respectively. Of 19 conservated eyeballs, 16 preserve useful vision (63%).
Zelter
M
M
Ophthalmology, Unit Hospital de Ninos, Buenos Aires, Argentina.
Gonzalez
G
G
Schwartz
L
L
Gallo
G
G
Schvartzman
E
E
Damel
A
A
Muriel
F S
FS
D000970:Antineoplastic Agents / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005134:Eye Neoplasms / Q000401:mortality / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects; D012175:Retinoblastoma / Q000401:mortality / Q000628:therapy*
D000970:Antineoplastic Agents