[Comparison of the radiosensitizing action of metronidazole administered orally and locally].
A local injection of metronidazole dissolved in dimethylsulfoxide reinforces the damaging effect of ionizing radiation on RL-67 adenocarcinoma cells to the same degree as was observed after oral administration thereof. However, with local administration, the dose of the preparation may be 12.5 times reduced.
Volchkov
V A
VA
Rudenko
I Ia
IIa
Zharinov
G M
GM
Khanson
K P
KP
Kholin
V V
VV
D000284:Administration, Oral; D000818:Animals; D003131:Combined Modality Therapy; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage; D007271:Injections, Intradermal; D008795:Metronidazole / Q000008:administration & dosage*; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage*
D011838:Radiation-Sensitizing Agents; D008795:Metronidazole; D004121:Dimethyl Sulfoxide
Sravnenie radiosensibiliziruiushchego deĭstviia metronidazola pri ego obshchem i mestnom primenenii.