Potassium supplementation lowers blood pressure in spontaneously hypertensive rats--relationships with urinary prostaglandins and renin.
Supplementation with 1% KCl significantly attenuated the blood pressure rise normally observed in SHR's with increasing age. Urine volume and urinary excretions of sodium, potassium and 6-keto-PGF1 alpha were significantly elevated in those animals receiving potassium. Plasma renin activity measured at the end of the study was significantly reduced in potassium supplemented animals compared to controls.
Barden
A
A
University Department of Medicine, Royal Perth Hospital.
Beilin
L J
LJ
Vandongen
R
R
D015121:6-Ketoprostaglandin F1 alpha / Q000652:urine; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000627:therapeutic use*; D011453:Prostaglandins / Q000652:urine*; D051381:Rats; D011918:Rats, Inbred SHR; D012083:Renin / Q000097:blood*
D011453:Prostaglandins; D015121:6-Ketoprostaglandin F1 alpha; D012083:Renin; D011188:Potassium