Pharmacokinetics of doxycycline in dogs.
Six adult dogs were given doxycycline hyclate at a dosage of 5 mg/kg of body weight intravenously so that pharmacokinetic parameters could be evaluated. Serum doxycycline concentrations were determined over a 48 h period using a modified agar well bioassay. Compartmental pharmacokinetic evaluation of the serum concentration time data indicated that doxycycline has a half-life of 10.36 h, a body clearance of 1.68 +/- 0.44 mL/min/kg, and a volume of distribution at steady state of 1.468 +/- 0.237 L/kg. Doxycycline pharmacokinetics are favorable for therapeutic use in the dog.
Wilson
R C
RC
Department of Physiology, College of Veterinary Medicine, Auburn University, Alabama 36849.
Kemp
D T
DT
Kitzman
J V
JV
Goetsch
D D
DD
D000818:Animals; D004285:Dogs / Q000378:metabolism*; D004318:Doxycycline / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D008838:Microcomputers; D012984:Software
D004318:Doxycycline