[Effect of cephalosporins on lymphocyte proliferation and immunoglobulin E production].
We studied the effects of three cephalosporins (cefadroxil, cefaclor, cephalexin) on an in vitro model of human mononuclear cell proliferation in response to polyclonal mitogens. Cefadroxil, and to a lesser extent cefaclor and cephalexin, induced a decrease of proliferative responses to phytohaemagglutinin and concanavalin A. This decrease was not due to a direct effect on lymphocytes, but depended on the presence of adherent monocytes in the cultures. Cephalosporins stimulated the release of prostaglandins E2 by monocytes, generating a suppressive activity. Cefadroxil and cephalexin were in vivo given to Brown-Norway rats sensitized to DNP-OVA to induce a primary and secondary IgE specific response. The administration of cefadroxil provoked a clear decrease of the secondary IgE response. As the IgE production closely depends on T suppressor cells, we hypothesize that cefadroxil could interfere with that production by stimulating a suppressor cell activity linked to an increased PGE2-release.
Clot
J
J
Laboratorie d'Immunologie-INSERM U 291, Hôpital Saint-Eloi, Montpellier.
Pelous
C
C
Carrière
V
V
Dessaint
J P
JP
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002511:Cephalosporins / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D008214:Lymphocytes / Q000166:cytology* / Q000378:metabolism; D010835:Phytohemagglutinins / Q000494:pharmacology; D011458:Prostaglandins E / Q000096:biosynthesis; D051381:Rats; D011914:Rats, Inbred BN
D002511:Cephalosporins; D010835:Phytohemagglutinins; D011458:Prostaglandins E; D003208:Concanavalin A; D007073:Immunoglobulin E
Effets des céphalosporines sur la prolifération des lymphocytes et la production d'immunoglobuline E.