title: Susceptibility of Nocardia asteroides to new quinolones and beta-lactams.
abstract: The susceptibility of 31 strains of Nocardia asteroides to various quinolones and beta-lactams, as well as coumermycin, amikacin, and minocycline, was determined by the agar dilution technique. Ciprofloxacin was the most active fluoroquinolone tested on a weight basis, as it inhibited approximately 50% of the isolates at achievable drug levels in serum. Ceftriaxone and cefpirome were the most active cephalosporins in this system with MICs of 8 micrograms/ml for 80% of strains tested. Imipenem, amikacin, and minocycline were the most effective agents tested.
authors.affiliation: Department of Medicine, State University of New York, Brooklyn 11203.
authors.forename: M E
authors.initials: ME
authors.lastname: Gombert
authors.forename: T M
authors.initials: TM
authors.lastname: Aulicino
authors.forename: L
authors.initials: L
authors.lastname: duBouchet
authors.forename: L R
authors.initials: LR
authors.lastname: Berkowitz
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009616:Nocardia asteroides / Q000187:drug effects*; D011804:Quinolines / Q000494:pharmacology*; D047090:beta-Lactams
chemical_list: D000900:Anti-Bacterial Agents; D011804:Quinolines; D047090:beta-Lactams