Transplantation of human basal cell carcinoma to C57/BALB/C bgJ/bgJ-nu/nu (beige-nude) mouse.
The purpose of this study was to evaluate the transplantation of BCC to the C57/BALB/C bgJ/bgJ-nu/nu (beige-nude) mouse. This animal has two gene defects which are expressed as impairment of natural killer cells (NK cells) as well as the absence of a thymus. The results demonstrate that human BCC can be successfully transplanted to the C57 beige-nude mouse without the need for supplemental immunosuppression. It may be that the impairment of NK cell activity in the beige-nude mouse model plays a significant role in tumor transplantation.
Grimwood
R E
RE
Department of Medicine, Ohio State University, Columbus.
Glanz
S M
SM
Siegle
R J
RJ
D000818:Animals; D000961:Antilymphocyte Serum; D002280:Basal Cell Carcinoma; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D008819:Mice, Nude / Q000276:immunology*; D009368:Neoplasm Transplantation; D013156:Splenectomy
D000961:Antilymphocyte Serum