Excretion of digoxin-like immunoreactivity in urine of normal subjects: correlations with excretion of creatinine and electrolytes.
To verify whether there is a variation in the 24-h urinary excretion of digoxin-like immunoreactivity (DLIS) in humans, we studied 18 normal adults, who collected their urines for 24-h in several portions. We then measured DLIS (by means of a sensitive RIA method), creatinine, sodium, and potassium concentrations in the urine samples. The mean urinary excretion rate for DLIS in the complete 24-h collection was 84.8 (SD 31.3) pg/min. The mean DLIS urinary excretion rate calculated for overnight collections was significantly lower than those of afternoon collections (P less than 0.01) and the 24-h collection (P less than 0.05). Significant positive correlations were found between urinary DLIS and excretion rates for creatinine (r = 0.347, P = 0.0016), Na+ (r = 0.232, P = 0.038), and K+ (r = 0.323, P = 0.003), respectively. Our data suggest that urinary excretion of DLIS is higher during "active" hours of the day, especially in the afternoon, than at rest, during the night.
Clerico
A
A
C.N.R. Institute of Clinical Physiology, University of Pisa, Italy.
Giampietro
O
O
Gregori
G
G
Del Chicca
M G
MG
Bertoli
S
S
Miccoli
R
R
Navalesi
R
R
D000328:Adult; D001798:Blood Proteins / Q000652:urine*; D002298:Cardenolides; D003404:Creatinine / Q000652:urine*; D004077:Digoxin; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000652:urine*; D012016:Reference Values; D012503:Saponins; D012964:Sodium / Q000652:urine*
D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D012964:Sodium; D003404:Creatinine; D011188:Potassium