Peri-operative blood loss and non-steroidal anti-inflammatory drugs: an investigation using diclofenac in patients undergoing transurethral resection of the prostate.
Peri-operative blood loss was compared in a prospective, randomized double-blind study between two groups of patients undergoing transurethral prostatectomy (TURP) under spinal (subarachnoid) analgesia: the first received the non-steroidal anti-inflammatory drug diclofenac sodium, the second group received placebo. The total blood loss and the blood loss per gram of prostate resected did not differ significantly. Some 80% of patients were completely pain free at 8 and 24 h post-operation, and low pain scores recorded by the remaining 20% of patients supported the conclusion that TURP performed under spinal analgesia is not commonly associated with severe post-operative pain.
Bricker
S R
SR
University Department of Anaesthesia, Royal Infirmary, Leicester, United Kingdom.
Savage
M E
ME
Hanning
C D
CD
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D004008:Diclofenac / Q000009:adverse effects*; D004311:Double-Blind Method; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011468:Prostatectomy; D011897:Random Allocation
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac