The role of bone marrow transplantation following nuclear accidents.
Hematopoietic stem cells are extremely sensitive to damage by ionizing radiation. At high doses of radiation, toxicity to the bone marrow may be operationally irreversible. Insufficient functional hematopoietic stem cells remain or irradiated individuals cannot survive sufficiently long enough for functional stem cell recovery. Both situations can be approached by bone marrow transplantation. This review considers the possible uses and limitations of bone marrow transplantation following nuclear accidents.
Gale
R P
RP
Department of Medicine, UCLA School of Medicine 90024.
D000059:Accidents; D000818:Animals; D016026:Bone Marrow Transplantation; D002056:Burns / Q000628:therapy; D006801:Humans; D051379:Mice; D009688:Nuclear Reactors; D011832:Radiation Injuries / Q000628:therapy*; D012871:Skin Diseases / Q000628:therapy