[Role of 5-bromodeoxyuridine in the formation of sister chromatid exchanges in human lymphocytes exposed to gamma-irradiation at the presynthetic stage of the mitotic cycle].
The formation of SCE was studied in human lymphocytes irradiated at the presynthetic stage of the cell cycle in the presence or absence of 5-bromodeoxyuridine. The results obtained showed that 5-bromodeoxyuridine present in the culture medium at the time of exposure or during the postirradiation period increased the yield of SCE. It is suggested that 5-bromodeoxyuridine exerts its effect through interfering with DNA repair.
Kondrashova
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D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects*; D012854:Sister Chromatid Exchange / Q000187:drug effects* / Q000528:radiation effects
D001973:Bromodeoxyuridine
Rol' 5-bromdezoksiuridina v obrazovanii DKhO pri gamma-obluchenii limfotsitov cheloveka na presinteticheskoĭ stadii mitoticheskogo tsikla.