title: Genetic analysis in rheumatoid arthritis.
abstract: The use of heritability studies, haplotype sharing, and lod score analysis are reviewed. Twin and family studies show that any genes conferring susceptibility to rheumatoid arthritis must have a relatively low penetrance. This is a serious obstacle to linkage analysis in families. Where there is a population association, as with DR4, studies of haplotype sharing by affected sibs may yield more information if the observations are compared with the sharing predicted from the population association.
authors.affiliation: Department of Medical Genetics, St Mary's Hospital, Manchester.
authors.forename: A P
authors.initials: AP
authors.lastname: Read
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics*; D004198:Disease Susceptibility; D004200:Diseases in Twins; D004843:Epistasis, Genetic; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D014430:Twins, Monozygotic
chemical_list: D005819:Genetic Markers