title: [Usefulness of fructosamine determination in short-term monitoring of metabolic control in children with insulin-dependent diabetes mellitus at onset].
abstract: The present study was undertaken to determine the clinical usefulness of fructosamine estimations in monitoring the short term changing in metabolic control in 5 newly diagnosed type 1 diabetic children (3 boys, 2 girls, aged 3-13 years). Mean glycaemic values, HbAlc (normal range: 4.77 +/- 0.67%), fructosamine (normal range: 2.65 +/- 0.65 mmol/l) were determined at the admission and after 1, 2, 3, 4 weeks. Normoglycaemia was achieved within 1 week (mean values: 232 +/- 107 mg% at admission; 98 +/- 39 mg% after 1 week of insulin therapy), HbAlc slightly decreased from 12 +/- 0.71 at admission to 9.90 +/- 1.81 after 4 weeks, but not reached normal values. Fructosamine decreased from 5.49 mmol/l to near normal values (3.02 +/- 0.67) after 4 weeks. The validity of the method was confirmed by the comparison of HbAlc and fructosamine in 22 stable long-standing diabetic children (r = 0.77, p less than 0.01). Compared with HbAlc, fructosamine appeared more useful in monitoring short term (3 weeks) changes in metabolic control. Additional advantages were lower cost and technical simplicity of measurement.
authors.affiliation: Clinica Pediatrica dell'Università, Ospedale Infantile Burlo Garofalo, Trieste, Italia.
authors.forename: C
authors.initials: C
authors.lastname: De Campo
authors.forename: C
authors.initials: C
authors.lastname: Monciotti
authors.forename: F
authors.initials: F
authors.lastname: Grossi
authors.forename: A
authors.initials: A
authors.lastname: Bertotti
authors.forename: M
authors.initials: M
authors.lastname: Pocecco
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D002151:Calorimetry; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D005260:Female; D019270:Fructosamine; D006442:Glycated Hemoglobin / Q000032:analysis; D006595:Hexosamines / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008991:Monitoring, Physiologic; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D019270:Fructosamine; D006442:Glycated Hemoglobin; D006595:Hexosamines; D007328:Insulin
vernacular_title: Utilità del dosaggio delle fruttosamine nel monitoraggio a breve termine del controllo metabolico in bambini affetti da diabete mellito insulino-dipendente all'esordio.