Triple nuclear NMR studies of cerebral metabolism during generalized seizure.
Noninvasive NMR spectroscopy of 1H, 31P, and 23Na is performed simultaneously to study brain metabolism during grand mal seizures. Decreases in PCr and increases in lactate associated with seizure as well as an intracellular shift of the Na+ ion pool are demonstrated. A close correlation between the phosphate potential and the intensity of the seizure, as well as the intra/extracellular ionic gradient, is shown.
Schnall
M D
MD
University of Pennsylvania, Department of Biochemistry and Biophysics, Philadelphia 19104.
Yoshizaki
K
K
Chance
B
B
Leigh
J S
JS
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002415:Cats; D004734:Energy Metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D012640:Seizures / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
D007773:Lactates; D019344:Lactic Acid; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D012964:Sodium