The effect of aerosolized verapamil on the response to isoproterenol in asthmatics.
Calcium antagonists, like verapamil, may play a beneficial role in the management of airway disease. However, the effect that verapamil plays in modulating the response to beta-adrenergic bronchodilator therapy has not been well characterized. We found that inhaled verapamil, 3 mg, had little effect on the bronchodilator response to sequential inhalations of isoproterenol. Also, verapamil had no significant effect on isoproterenol's protection against methacholine-induced bronchospasm in a group of 8 mild asthmatics. These studies support the safe use of these agents in combination but do not demonstrate any additive or synergistic benefit.
Greenspon
L W
LW
Pulmonary Disease Section, the Medical College of Pennsylvania, Philadelphia 19129.
Levy
S F
SF
D000328:Adult; D000336:Aerosols; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects; D001985:Bronchial Provocation Tests; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007545:Isoproterenol / Q000008:administration & dosage*; D008297:Male; D014700:Verapamil / Q000008:administration & dosage*
D000336:Aerosols; D014700:Verapamil; D007545:Isoproterenol