Safety and immunogenicity of a vaccine bait containing ERA strain of attenuated rabies virus.
Ninety percent of foxes fed commercial ERA vaccine in a specially designed bait developed rabies serum neutralizing antibodies. The vaccine bait did not cause clinical signs of rabies when consumed by foxes, raccoons, skunks, dogs, cats, cattle and monkeys. When presented, in the laboratory, to wild rodents of the species Microtus, Mus musculus and Peromyscus, the vaccine baits caused vaccine-induced rabies only in Mus musculus. Laboratory mice of the CD-1 and CLL strain were susceptible to vaccine-induced rabies; however, studies showed that transmission of virus to other animals did not occur. These studies suggest that the vaccine bait described could be useful in a rabies control program in areas where foxes and wild dogs are the principal vectors.
Lawson
K F
KF
Connaught Laboratories Limited, Willowdale, Ontario.
Black
J G
JG
Charlton
K M
KM
Johnston
D H
DH
Rhodes
A J
AJ
D000818:Animals; D000835:Animals, Wild / Q000276:immunology*; D000914:Antibodies, Viral / Q000096:biosynthesis*; D003411:Arvicolinae / Q000276:immunology; D002415:Cats; D002417:Cattle; D004285:Dogs; D005455:Fluorescent Antibody Technique; D005589:Foxes / Q000276:immunology; D008253:Macaca mulatta / Q000276:immunology; D008297:Male; D012889:Mephitidae / Q000276:immunology; D051379:Mice; D010542:Peromyscus / Q000276:immunology; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*; D011821:Raccoons / Q000276:immunology; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology
D000914:Antibodies, Viral; D011819:Rabies Vaccines; D014613:Vaccines, Attenuated