Peripheral serotoninergic receptor sensitivity in senile dementia of the Alzheimer type.
Platelet aggregation induced by 5-hydroxytryptamine (5-HT) was used as a measure of the functional responsiveness of peripheral 5-HT receptors in controls and drug-free patients suffering from senile dementia of Alzheimer type (SDAT). No significantly different aggregatory response (5-HT/ADP ratio) was noted between the two groups of subjects. If the receptor mediating this response is a 5-HT2 receptor, there is no evidence to suggest that the functional activity of this system is abnormal in SDAT.
Thomas
D R
DR
Department of Psychological Medicine, University of Wales College of Medicine, Whitchurch Hospital, Cardiff, Great Britain.
Jones
E
E
Warner
N
N
Harris
B
B
Williams
P
P
Bentley
P
P
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism* / Q000503:physiopathology; D003704:Dementia / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D010974:Platelet Aggregation; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000502:physiology*
D011985:Receptors, Serotonin; D012701:Serotonin