Dystrophic chick brain lacks a particular neurotrophic factor.
Extracts from normal embryonic chick brain act as "trophic" agents in the newt blastemata assay where they stimulate the incorporation of amino acids into protein. Equivalent extracts prepared from the brains of dystrophic (am/am) chick embryos are apparently devoid of any equivalent activity.
Logan
D M
DM
Biology Department, York University, Ontario.
D000818:Animals; D001681:Biological Assay; D001923:Brain Chemistry; D002642:Chick Embryo; D009137:Muscular Dystrophy, Animal / Q000196:embryology / Q000378:metabolism*; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins / Q000172:deficiency*; D009994:Osmolar Concentration; D014176:Protein Biosynthesis; D012455:Salamandridae; D014020:Tissue Extracts / Q000494:pharmacology
D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D014020:Tissue Extracts