Histological localization of 4-S-cysteinylphenol in melanoma-bearing mice.
4-S-cysteinylphenol (4-S-CP), the S-homologue of tyrosine, has been recently synthesized as a selective chemotherapeutic agent against malignant melanoma and has been shown to be a specific substrate for tyrosinase in vitro. In vivo incorporation of 4-S-CP into the B16 and Harding Passey (HP) melanomas and the systemic organs have been evaluated by the autoradiographic method. The distribution of the silver grains indicated that 4-S-CP was selectively incorporated into both the B16 and HP melanomas. 4-S-CP was excreted mainly from the kidneys and there was an accumulation of 4-S-CP in the reticulo-endothelial system. These results seemed to contribute to the utilization of 4-S-CP and other related compounds as chemotherapeutic agents against malignant melanoma.
Nakamura
T
T
Second Department of Pathology, Faculty of Medicine, Tokyo Medical and Dental University.
Matsubara
O
O
Kasuga
T
T
Suzuki
J
J
Ishikawa
K
K
Ito
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000032:analysis* / Q000493:pharmacokinetics; D001853:Bone Marrow / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D003545:Cysteine / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics; D004817:Epidermis / Q000378:metabolism; D006652:Histological Techniques; D007684:Kidney Tubules / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008546:Melanoma, Experimental / Q000032:analysis* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000378:metabolism
D000970:Antineoplastic Agents; C043036:4-S-cysteinylphenol; D003545:Cysteine