Effects of pulsed extremely-low-frequency magnetic fields on skin wounds in the rat.
Rats with skin-wounds surgically created on their backs were exposed immediately after surgery and every 12 h thereafter to pulsed, extremely-low-frequency magnetic fields. The shape of the pulse was a positive triangle (50 Hz, 8 mT peak). The rate of healing of skin wounds was evaluated macroscopically and by light and electron microscopy at 6, 12, 21, and 42 days after the operation. A significant increase in the rate of wound contraction was found in rats treated with magnetic fields. Forty-two days after surgery all treated animals show fully closed wounds, while control rats at the same time intervals still lacked a final 6% of the wound surface to be covered. Treated rats showed earlier cellular organization, collagen formation and maturation, and a very early appearance of newly formed vascular network.
Ottani
V
V
Istituto di Anatomia Umana Normale, Bologna, Italy.
De Pasquale
V
V
Govoni
P
P
Franchi
M
M
Zaniol
P
P
Ruggeri
A
A
D000818:Animals; D003094:Collagen / Q000032:analysis; D004574:Electromagnetic Fields; D055590:Electromagnetic Phenomena; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000648:ultrastructure; D013997:Time Factors; D014945:Wound Healing
D003094:Collagen