title: Immunological and molecular studies in a case of follicular lymphoma with an extra chromosome 12 and t(2;8) translocation.
abstract: Two sequential lymph node biopsies taken from a non-Hodgkin lymphoma patient revealed two karyotype abnormalities peculiar to B cell neoplasias: trisomy 12 and t(2;8)(p12;q24) translocation. The first was documented in all cells analyzed, while the second was present in 20% of the metaphases from the first biopsy and in 100% from the second. This suggests that the t(2;8) translocation arose as a secondary karyotypic change. In addition, although immunological characterization of the neoplastic cells disclosed a monoclonal B cell population that expressed immunoglobulin kappa light chains, as usually found in Burkitt's lymphoma with t(2;8) translocation, Southern blot analysis provided evidence of rearrangement in only one kappa chain allele.
authors.affiliation: First Institute of Internal Medicine, University of Perugia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Donti
authors.forename: B
authors.initials: B
authors.lastname: Falini
authors.forename: P
authors.initials: P
authors.lastname: Giuseppe Pelicci
authors.forename: G
authors.initials: G
authors.lastname: Venti Donti
authors.forename: A
authors.initials: A
authors.lastname: Rosetti
authors.forename: M
authors.initials: M
authors.lastname: Martelli
authors.forename: F
authors.initials: F
authors.lastname: Grignani
mesh_terms: D002869:Chromosome Aberrations / Q000150:complications*; D025063:Chromosome Disorders; D002881:Chromosomes, Human, Pair 12; D006801:Humans; D007621:Karyotyping; D008223:Lymphoma / Q000150:complications / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008967:Molecular Biology; D014178:Translocation, Genetic