Experimental evaluation of the antibiotic carrying capacity of a muscle flap into a fibrotic cavity.
A study was undertaken to determine the antibiotic carrying capacity of a transferred muscle flap into a fibrotic cavity using a tissue cage model in rabbits. Blood and chamber fluid antibiotic levels were determined after intramuscular hindlimb gentamicin injection up to 56 days following muscle transfer. This study suggests that muscle flaps increase the concentration of antibiotics that can be achieved within a fibrotic cavity. The measurable peak level decreases with time, probably due to increased scarring around the muscle. This model should enable the study of many different classes of antibiotics with different protein binding and other administration schedules using multiple timed doses or a combination of agents.
Russell
R C
RC
Division of Plastic and Reconstructive Surgery, Southern Illinois University School of Medicine, Springfield.
Graham
D R
DR
Feller
A M
AM
Zook
E G
EG
Mathur
A
A
D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy; D005355:Fibrosis; D005839:Gentamicins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy; D011817:Rabbits; D013524:Surgical Flaps; D013997:Time Factors
D000900:Anti-Bacterial Agents; D005839:Gentamicins