Disopyramide-induced hypoglycaemia and increased serum insulin.
A patient treated with disopyramide presented with hypoglycaemia, a raised serum insulin level and died of pneumonia. From these findings and a review of 10 case reports, we propose that disopyramide causes hypoglycaemia by stimulation of insulin release as described for the antimalarial drugs quinine and quinidine.
Croxson
M S
MS
Department of Endocrinology, Auckland Hospital.
Shaw
D W
DW
Henley
P G
PG
Gabriel
H D
HD
D000368:Aged; D004206:Disopyramide / Q000009:adverse effects*; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced*; D007328:Insulin / Q000097:blood*; D008297:Male; D013268:Stimulation, Chemical
D007328:Insulin; D004206:Disopyramide