title: Treatment of retinoblastoma. Results obtained from a prospective study of 51 patients.
abstract: During 4 years, 51 patients with retinoblastoma were studied (unilateral 32, and bilateral 19). Treatment consisted of enucleation of those eyes which showed massive involvement followed by radiotherapy when there was optic nerve and/or orbit involvement. Systemic chemotherapy was administered to all patients who underwent nonsurgical treatment and when the histologic examination showed choroidal optic nerve head and/or optic nerve involvement or residual tumor after enucleation. When there was compromise of the central nervous system intrathecal chemotherapy was administered. Nonsurgical treatment consisted of radiotherapy and/or light coagulation. Survival was 90.6% for unilateral cases and 84.2% for the bilateral. The median follow-up was 31 months and 29 months, respectively. Of 19 conservated eyeballs, 16 preserve useful vision (63%).
authors.affiliation: Ophthalmology, Unit Hospital de Ninos, Buenos Aires, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Zelter
authors.forename: G
authors.initials: G
authors.lastname: Gonzalez
authors.forename: L
authors.initials: L
authors.lastname: Schwartz
authors.forename: G
authors.initials: G
authors.lastname: Gallo
authors.forename: E
authors.initials: E
authors.lastname: Schvartzman
authors.forename: A
authors.initials: A
authors.lastname: Damel
authors.forename: F S
authors.initials: FS
authors.lastname: Muriel
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005134:Eye Neoplasms / Q000401:mortality / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects; D012175:Retinoblastoma / Q000401:mortality / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents