Isosexual precocious puberty.
Isosexual precocious puberty refers to the appearance of phenotypically appropriate secondary sexual characteristics before age 8 years in girls and before 9 years in boys. Isosexual precocity may be categorized into several subgroups depending upon etiology and clinical course: true and complete isosexual precocity refers to early activation of the intact hypothalamic-pituitary-gonadal axis; pseudo-isosexual precocity is due to sex steroid production which is independent of hypothalamic-pituitary regulation; incomplete forms of isosexual precocity include premature thelarche and premature adrenarche. Etiologic, diagnostic and therapeutic considerations are discussed.
Shulman
D I
DI
Department of Pediatrics, University of South Florida College of Medicine, Tampa.
D000367:Age Factors; D000728:Androgens / Q000378:metabolism; D002648:Child; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D008297:Male; D008572:Menarche; D010906:Pituitary Hormone-Releasing Hormones / Q000627:therapeutic use; D011629:Puberty, Precocious / Q000145:classification / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D012727:Sex Characteristics; D012741:Sexual Maturation
D000728:Androgens; D010906:Pituitary Hormone-Releasing Hormones