title: Adverse reactions to Bactrim--a retrospective view.
abstract: A historical survey based on the most important literature is presented as a starting point for further discussion on the significance of possible adverse reactions reported after prescription of cotrimoxazole. The often changing and contradictory assessments made of the situation in different countries and at different times are outlined, and the difficulty of making a balanced and just evaluation of long established drugs is shown, particularly if the available data are derived primarily from spontaneous reports which, besides being almost impossible to verify, are often incomplete.
authors.affiliation: F. Hoffmann-La Roche and Co. Ltd., Basle, Switzerland.
authors.forename: K
authors.initials: K
authors.lastname: Hell
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D006801:Humans; D013420:Sulfamethoxazole / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
chemical_list: D000890:Anti-Infective Agents; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole