The effect of two new alpha-glucosidase inhibitors on metabolic responses to a mixed meal in normal volunteers.
1. alpha-Glucosidase inhibitors delay carbohydrate absorption and have been proposed as adjunctive therapy for diabetes mellitus. 2. To determine the effects of two new alpha-glucosidase inhibitors, Bay-m-1099 and Bay-o-1248, on meal carbohydrate and lipid tolerance, plasma glucose, insulin and triglyceride levels were measured at 15-60 min intervals over 12 h after ingestion of a standard breakfast, lunch and dinner of identical composition in 31 normal volunteers. 3. The volunteers were randomized to receive either Bay-m-1099 (50 or 25 mg) or placebo prior to each meal, or the single administration of Bay-o-1248 (20 or 10 mg) or placebo prior to breakfast. 4. Only Bay-m-1099 at the 50 mg dose reduced significantly the postprandial increase in plasma insulin levels after each meal when compared with placebo (25, 36, 54% at breakfast, lunch, and dinner, respectively; P less than 0.05). Both drugs were well tolerated, with side effects limited to complaints of flatulence. 5. Thus, with the dosage schedule employed, Bay-m-1099, but not Bay-o-1248, significantly reduced postprandial increments in plasma insulin.
Kennedy
F P
FP
Department of Medicine, Mayo Medical School, Rochester, Minnesota.
Miles
J M
JM
Heiling
V
V
Gerich
J E
JE
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005502:Food; D005944:Glucosamine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D050112:Imino Pyranoses; D007328:Insulin / Q000097:blood; D008297:Male; D014280:Triglycerides / Q000097:blood
D000900:Anti-Bacterial Agents; D001786:Blood Glucose; D065089:Glycoside Hydrolase Inhibitors; D050112:Imino Pyranoses; D007328:Insulin; D014280:Triglycerides; C045621:miglitol; D017485:1-Deoxynojirimycin; D005944:Glucosamine; C045622:emiglitate