A Cs-137 afterloading device. Preliminary results of cell kinetic effects of low dose-rate irradiation in an experimental tumour.
A Cs-137 afterloading technique is described which can be used in experimental tumours. Preliminary results, obtained with the human cervical carcinoma ME-180 xenografted to nude athymic mice, demonstrated that 20 Gy of low dose-rate irradiation induced an important redistribution of cells over cell cycle. The proportion of cells in G2-phase increased from 14.4% to 44.2% at 140 hours after irradiation. This method allows an accurate calculation of the dose-rate distribution in the tumour. Investigations of the cell kinetic effects of low dose-rate irradiation, at different dose-rates and different total doses, are therefore facilitated by the technique.
Rutgers
D H
DH
University Hospital, Department of Radiotherapy, Utrecht, The Netherlands.
D000818:Animals; D001918:Brachytherapy / Q000295:instrumentation* / Q000379:methods; D002277:Carcinoma / Q000532:radiotherapy*; D002453:Cell Cycle / Q000528:radiation effects; D002588:Cesium Radioisotopes / Q000627:therapeutic use*; D004307:Dose-Response Relationship, Radiation; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011879:Radiotherapy Dosage; D013997:Time Factors
D002588:Cesium Radioisotopes