[Preoperative intra-arterial infusion of adriamycin in advanced breast cancer with reference to estrogen receptor status].
Preoperative intra-arterial infusion of adriamycin [I I A] for advanced breast cancer was performed in 22 cases, and correlation of the estrogen receptor (ER) status with the effect of I I A therapy was histologically examined. Fifty-five percent of all cases responded to I I A; 80% of ER-negative cases responded, whereas only 33% of ER-positive cases did. I I A was significantly effective in ER-negative cases (p less than 0.05). The histological effect of I I A was also remarkable in ER-negative cases and was related to the clinical effect. The ER status was thought to be a parameter not only for hormonal therapy, but also for chemotherapy. Additionally, drill biopsy was performed in order to examine the correlation between the therapeutic effect and histological type in 16 cases before I I A therapy. Scirrhous carcinoma was more responsive to the I I A therapy than other histological types.
Tamura
G
G
Dept. of Pathology II, Iwate Medical University School of Medicine.
Iwasaki
T
T
Satodate
R
R
Kawamura
S
S
Kaizuka
H
H
Abe
H
H
Ishida
M
M
Saito
K
K
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000032:analysis / Q000188:drug therapy* / Q000473:pathology; D004317:Doxorubicin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D011300:Preoperative Care; D011960:Receptors, Estrogen / Q000032:analysis*
D011960:Receptors, Estrogen; D004317:Doxorubicin