Consistent involvement of band 12q14 in two different translocations in three lipomas from the same patient.
We studied cytogenetically three distinct lipomas from a patient with multiple subcutaneous lipomas in the left shoulder area. A breakpoint at 12q14 was involved in structural rearrangements in the three lipomas resulting in two different reciprocal translocations, i.e., t(3;12)(q28;q14) in two and a t(1;12)(q34.2;q14) in the third. These results confirm the consistency of involvement of the breakpoint at 12q14 in lipomas and give support to the hypothesis that multiple lipomas evolve from different stem cells.
Dal Cin
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Cancer Center, Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
Turc-Carel
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Sandberg
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AA
D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002881:Chromosomes, Human, Pair 12; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D008068:Lipomatosis / Q000235:genetics*; D008875:Middle Aged; D014178:Translocation, Genetic