Protection of rabbits in an infection model of toxic shock syndrome (TSS) by a TSS toxin-1-specific monoclonal antibody.
An anti-TSST-1-specific monoclonal antibody (MAb 8-5-7) was tested for its protective capacity in a rabbit infection model to toxic shock syndrome (TSS). The challenge strain of Staphylococcus aureus (RN4710), which contained a plasmid encoding TSS toxin-1, was introduced into previously implanted chambers. Purified monoclonal antibody (1.25 mg of immunoglobulin G) administered parenterally 1 day before and 1 day after initiation of infection provided complete protection against the TSS-like syndrome and the mortality which occurred in unprotected rabbits.
Best
G K
GK
Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912.
Scott
D F
DF
Kling
J M
JM
Thompson
M R
MR
Adinolfi
L E
LE
Bonventre
P F
PF
D000818:Animals; D000907:Antibodies, Bacterial / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001427:Bacterial Toxins; D004768:Enterotoxins / Q000276:immunology*; D007116:Immunization, Passive; D008297:Male; D009500:Neutralization Tests; D011817:Rabbits; D012772:Shock, Septic / Q000517:prevention & control*; D018089:Superantigens
D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D001427:Bacterial Toxins; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal