[Prevention of the formation of the infectious process with biologically active thymic factors in the Salmonella typhimurium challenge of mice coincident with macrophage activation].
A single injection of thymostimulin into mice in a dose of 45 micrograms/kg b.w. enhances the functional activity of macrophages, reaching it maximum on day 10, which prevents the formation of an infectious process in mice challenged with S. typhimurium (LD50). The irradiation of the animals in a sublethal dose leads to the complete abolition of the stimulating effect of thymostimulin on macrophages. The presence of an inducer mechanism of the activation of macrophages by thymostimulin, realized in the production of lymphokines, is suggested.
Grinevich
Iu A
IuA
Zaritskiĭ
A M
AM
Fil'chakov
I V
IV
Fil'chakov
F V
FV
Nikol'skiĭ
I S
IS
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D008099:Liver / Q000187:drug effects / Q000382:microbiology; D008262:Macrophage Activation / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D008808:Mice, Inbred CBA; D010587:Phagocytosis / Q000187:drug effects / Q000528:radiation effects; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control*; D012486:Salmonella typhimurium / Q000302:isolation & purification; D013949:Thymus Extracts / Q000627:therapeutic use*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D013949:Thymus Extracts; C031407:thymostimulin
Predotvrashchenie formirovaniia infektsionnogo protsessa biologicheski aktivnymi faktorami timusa pri zarazhenii mysheĭ Salmonella typhimurium, sovpadaiushchee s aktivatsieĭ makrofagov.