Correlation between iodine-131 MIBG imaging and biological markers in advanced neuroblastoma.
I-131 metaiodobenzylguanidine (MIBG) imaging was performed in 38 patients with advanced neuroblastoma. Abnormal images were found in patients with elevations of urinary vanillylmandelic acid and dopamine and high serum neuron-specific enolase levels. Normal or minimal elevation of markers was seen in patients with negative images. In follow-up studies after chemotherapy, the disappearance of abnormal uptake was noted in those patients with normal marker values. A persistently abnormal uptake occurred in patients with high marker values. Conversion from a normal image to an abnormal image also occurred in patients whose markers became elevated. I-131 MIBG imaging is sensitive in detecting active foci of a neuroblastoma and is useful in monitoring chemotherapy in these patients.
Yeh
S D
SD
Nuclear Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Helson
L
L
Benua
R S
RS
D019797:3-Iodobenzylguanidine; D014408:Biomarkers, Tumor / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004298:Dopamine / Q000652:urine; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D009447:Neuroblastoma / Q000097:blood / Q000000981:diagnostic imaging* / Q000652:urine; D010751:Phosphopyruvate Hydratase / Q000097:blood; D011877:Radionuclide Imaging; D014642:Vanilmandelic Acid / Q000652:urine
D014408:Biomarkers, Tumor; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine; D014642:Vanilmandelic Acid; D010751:Phosphopyruvate Hydratase; D004298:Dopamine