Metastatic colon cancer: correlation of oxygen levels with I-131 F(ab')2 uptake.
Tumor oxygen levels were measured with an electrode in 13 patients with colon carcinoma metastases. These measurements were correlated with images obtained with radiolabeled monoclonal antibody 1083-17-1A. Only those tumors or tumor regions with a mean PO2 of 16 mm Hg or greater were successfully imaged. Tumors and tumor regions with a mean PO2 of less than 16 mm Hg were not imaged, even when the presence of antigen was confirmed with biopsy. These data suggest that physiologic factors other than antigen expression may affect antibody uptake.
Gatenby
R A
RA
Fox Chase Cancer Center, Philadelphia, PA 19111.
Moldofsky
P J
PJ
Weiner
L M
LM
D000911:Antibodies, Monoclonal; D002277:Carcinoma / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism / Q000556:secondary; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007128:Immunoglobulin Fragments; D007457:Iodine Radioisotopes; D010100:Oxygen / Q000493:pharmacokinetics*
D000911:Antibodies, Monoclonal; D007128:Immunoglobulin Fragments; D007457:Iodine Radioisotopes; D010100:Oxygen