Influenza immunization in children with cystic fibrosis.
Nineteen children with cystic fibrosis and aged between 5 and 13 years were randomized to receive two doses at monthly intervals of either a split-virion influenza vaccine (MFV-Ject, Institut Merieux) or a sub-unit vaccine (Fluvirin, Evans). In those completing the study, there was a satisfactory serological response. There was no statistically significant difference between the immunogenicity of the two vaccines as evaluated by haemagglutination inhibition or single radial haemolysis tests. The incidence of local side-effects was similar in the two groups.
Adlard
P
P
Royal Manchester Children's Hospital, Pendlebury, Manchester, UK.
Bryett
K
K
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003550:Cystic Fibrosis / Q000276:immunology*; D005334:Fever / Q000209:etiology; D006193:Haemophilus influenzae / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007115:Immunization Schedule; D007252:Influenza Vaccines / Q000009:adverse effects / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D011897:Random Allocation; D014611:Vaccination / Q000009:adverse effects
D000914:Antibodies, Viral; D007252:Influenza Vaccines