Effect of light deprivation on the ERG responses of taurine-deficient rats.
The decrease of taurine levels in the retina of taurine-depleted rats treated with guanidinoethane sulfonate (GES) reduced the amplitude of the a- and b-waves of the electroretinogram, registered as a function of the log relative intensity stimulus. The effect was observed either in rats exposed to a light-darkness cycle or to continuous darkness; this effect was somewhat more pronounced in retinas of rats exposed to light. Values obtained from the Naka-Rushton equation for the V-log I curve for the a-wave showed that the half-saturating intensity was unchanged but Vmax was decreased by GES treatment. Implicit times for the b-wave delayed whereas those for the a-wave were unaffected by the treatment.
Quesada
O
O
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, D.F., México.
Picones
A
A
Pasantes-Morales
H
H
D000818:Animals; D003624:Darkness; D004596:Electroretinography; D008027:Light; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D012683:Sensory Deprivation / Q000502:physiology*; D013654:Taurine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D013997:Time Factors
D013654:Taurine; C009558:taurocyamine