A controlled trial of nebulized aminoglycoside and oral flucloxacillin versus placebo in the outpatient management of children with cystic fibrosis.
Six children with cystic fibrosis who had persistently had Pseudomonas aeruginosa isolated from their respiratory tract, completed a double-blind cross-over comparison of oral flucloxacillin and nebulized aminoglycoside versus double placebo. The patients had higher FEV1 results at the end of the month of active treatment than after the month of placebo.
Carswell
F
F
Department of Child Health, University of Bristol.
Ward
C
C
Cook
D A
DA
Speller
D C
DC
D000280:Administration, Inhalation; D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D002986:Clinical Trials as Topic; D003023:Cloxacillin / Q000031:analogs & derivatives*; D003550:Cystic Fibrosis / Q000188:drug therapy* / Q000382:microbiology; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005436:Floxacillin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011552:Pseudomonas Infections / Q000188:drug therapy; D014031:Tobramycin / Q000008:administration & dosage / Q000627:therapeutic use*
D005436:Floxacillin; D003023:Cloxacillin; D014031:Tobramycin