Comparison of nifedipine with a new calcium channel blocker, flordipine, in exercise-induced asthma.
Four patients with documented exercise-induced asthma (EIA) were pretreated orally in random, double-blind fashion with the calcium channel blockers nifedipine 20 mg and flordipine 25 and 50 mg and placebo, then subjected to exercise challenge on a cycloergometer. Each patient served as his own control, undergoing exercise challenge with the different pretreatments on 4 separate days. No statistically significant protection from EIA was found with either nifedipine or flordipine.
Gordon
E H
EH
Department of Medicine, Wadsworth VA Medical Center, Los Angeles, California 90073.
Wong
S C
SC
Klaustermeyer
W B
WB
D000328:Adult; D001249:Asthma / Q000517:prevention & control*; D001250:Asthma, Exercise-Induced / Q000188:drug therapy / Q000517:prevention & control*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005080:Exercise Test; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D009539:Nicotinic Acids / Q000627:therapeutic use*; D009543:Nifedipine / Q000627:therapeutic use*; D012129:Respiratory Function Tests
D002121:Calcium Channel Blockers; D009539:Nicotinic Acids; D009543:Nifedipine; C042357:flordipine