Effect of different caloric loads in human jejunum on meal-stimulated and nonstimulated biliopancreatic secretion.
The effects on biliopancreatic secretion of two caloric loads (1.3 and 3.3 kcal/min of Realmentyl: proteins 18%, lipids 27%, carbohydrates 55%), infused into the jejuna of 10 healthy men, were compared with those of a control solution. In one set of experiments (six subjects) when biliopancreatic secretion was not stimulated before infusion, the rate 1.3 kcal/min resulted in mild stimulation whereas the rate 3.3 kcal/min brought about an inhibition of biliopancreatic secretion. In another set of experiments (six subjects) when biliopancreatic secretion was stimulated by ingestion of an homogenized meal (400 mL, 490 kcal) 1 h before the start of infusion, both loads resulted in strong inhibition of pancreatic secretions, the effect being more pronounced with the high caloric load.
Vidon
N
N
Unité de Recherches sur la Physiopathologie de la Digestion (INSERM U54), Hôpital Saint Lazare, Paris, France.
Pfeiffer
A
A
Franchisseur
C
C
Bovet
M
M
Rongier
M
M
Bernier
J J
JJ
D000328:Adult; D001647:Bile Acids and Salts / Q000378:metabolism*; D002918:Chymotrypsin / Q000378:metabolism*; D002149:Energy Intake; D005526:Food, Formulated; D005746:Gastric Emptying; D006801:Humans; D007408:Intestinal Absorption; D007583:Jejunum / Q000502:physiology*; D008049:Lipase / Q000378:metabolism*; D008297:Male; D010179:Pancreas / Q000378:metabolism*
D001647:Bile Acids and Salts; D008049:Lipase; D002918:Chymotrypsin