Enhancement of lectin-induced cap formation in human neutrophils by cyclosporin A.
Cyclosporin A, a potent immunosuppressive agent, has been extensively studied for its immunomodulatory effects on T-cells. Recently Cyclosporin A has been shown to cause renal damage, which correlates with increased glomerular neutrophil migration. The precise role of Cyclosporin A on neutrophil function has not been established. In this study we investigated the role of Cyclosporin A in the regulation of cap formation in human neutrophils. Our results show an increased concanavalin A-induced cap formation in human neutrophils pretreated with Cyclosporin A, implicating a possible role of Cyclosporin A in human neutrophil activation. The correlation between enhanced capping, renal nephrotoxicity and neutrophil migration remains to be studied.
Soon-Shiong
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Department of Surgery, UCLA Medical Center.
Grewal
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D003208:Concanavalin A / Q000494:pharmacology*; D003524:Cyclosporins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007152:Immunologic Capping / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology
D003524:Cyclosporins; D003208:Concanavalin A