title: Femur fracture with associated soft-tissue injury produces hepatic ischemia. Possible cause of hepatic dysfunction.
abstract: Clinical studies demonstrate that early débridement and operative fixation of femur fractures in multiply injured patients lowers both the incidence and severity of hepatic failure. Perhaps the single most important determinant of hepatic function is nutrient hepatic perfusion. This study compares systemic and hepatic blood flow in rats that have sustained femur fractures with or without associated soft-tissue injury. Femur fracture without soft-tissue trauma resulted in a hyperdynamic state with normal blood flow distribution at 24 hours after injury and normal hemodynamics at 48 hours. When femur fracture was associated with soft-tissue trauma, the elevated cardiac output at 24 hours was not matched by a proportionately elevated hepatic blood flow. In this latter group, the cardiac output was normal at 48 hours, but the hepatic perfusion defect remained. Retained fracture fragments, hematoma, and injured and necrotic soft tissue may serve as a stimulus leading to a pathologic reduction in hepatic perfusion.
authors.affiliation: Department of Surgery, Veterans Administration Medical Center, Cleveland, OH 44106.
authors.forename: W J
authors.initials: WJ
authors.lastname: Schirmer
authors.forename: J M
authors.initials: JM
authors.lastname: Schirmer
authors.forename: M C
authors.initials: MC
authors.lastname: Townsend
authors.forename: D E
authors.initials: DE
authors.lastname: Fry
mesh_terms: D000818:Animals; D002302:Cardiac Output; D005260:Female; D005264:Femoral Fractures / Q000150:complications* / Q000503:physiopathology; D005596:Fractures, Closed / Q000150:complications / Q000503:physiopathology; D005597:Fractures, Open / Q000150:complications* / Q000503:physiopathology; D006439:Hemodynamics; D007511:Ischemia / Q000209:etiology* / Q000503:physiopathology; D008099:Liver / Q000098:blood supply* / Q000503:physiopathology; D051381:Rats