title: DL-myo-inositol 1,4,5-trisphosphorothioate mobilizes intracellular calcium in Swiss 3T3 cells and Xenopus oocytes.
abstract: The initial water-soluble product of receptor-stimulate polyphosphoinositide hydrolysis, D-myo-inositol 1,4,5-trisphosphate is now accepted as the second messenger that stimulates release of Ca2+ from intracellular pools. We report here the first examples of Ca2+ release by a novel phosphatase-resistant inositol trisphosphate analogue, DL-myo-inositol 1,4,5-trisphosphorothioate, in Swiss 3T3 cells and Xenopus oocytes. L-myo-inositol 1,4,5-trisphosphate was inactive in the latter system.
authors.affiliation: AFRC Unit of Insect Neurophysiology and Pharmacology, Department of Zoology, Cambridge, UK.
authors.forename: C W
authors.initials: CW
authors.lastname: Taylor
authors.forename: M J
authors.initials: MJ
authors.lastname: Berridge
authors.forename: K D
authors.initials: KD
authors.lastname: Brown
authors.forename: A M
authors.initials: AM
authors.lastname: Cooke
authors.forename: B V
authors.initials: BV
authors.lastname: Potter
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002463:Cell Membrane Permeability; D002478:Cells, Cultured; D005260:Female; D007294:Inositol / Q000031:analogs & derivatives* / Q000494:pharmacology; D015544:Inositol 1,4,5-Trisphosphate / Q000031:analogs & derivatives; D007700:Kinetics; D051379:Mice; D009865:Oocytes / Q000187:drug effects / Q000378:metabolism*; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D014982:Xenopus laevis
chemical_list: D009946:Organothiophosphorus Compounds; C054737:inositol 1,4,5-triphosphorothioate; D007294:Inositol; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium