[Effect of dalargin on blood and lymph microcirculation].
Dalargin (a synthetic analog of leu-enkephalin), when applied to the microvessel surface or administered intramuscularly at doses 0.004-40.0 micrograms/kg increased the permeability of the rat mesenteric microvascular wall and activated the lymph flow due to enhanced contraction of lymphatic microvascular wall and valves. Moreover, Dalargin evoked leukocyte migration from venules and activated the intestinal muscular contractions.
Khugaeva
V K
VK
D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D008196:Lymph / Q000187:drug effects*; D008208:Lymphatic System / Q000187:drug effects; D008297:Male; D008643:Mesentery / Q000098:blood supply / Q000187:drug effects*; D008833:Microcirculation / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie dalargina na mikrogemo- i mikrolimfotsirkuliatsiiu.