Neurochemical changes in rat brain amines after short- and long-term inhibition of monoamine oxidase by a low dose of tranylcypromine.
The effects of short- and long-term administration of a low dose of tranylcypromine on brain and urine levels of several biogenic amines and on brain activity of monoamine oxidases (MAO) A and B were investigated. MAO-A and MAO-B were inhibited by greater than 85% on day 1, and this inhibition continued to increase over the course of the study (42 days). Levels of 5-hydroxytryptamine in brain continued to increase up to day 21 and did not decline from day 21 to day 42, and levels of tranylcypromine itself continued to increase up to day 42. Dopamine concentrations peaked at day 10 and were not significantly different from that value by day 42. Brain levels of tryptamine and beta-phenylethylamine showed dramatic elevations after the first dose of the drug and remained essentially unchanged from those high values throughout the course of the drug treatment. Brain and urine increases in tryptamine and beta-phenylethylamine showed similar patterns, whereas urinary 5-hydroxytryptamine excretion reached maximal levels earlier than did brain levels.
Hampson
D R
DR
Department of Psychiatry, University of Alberta, Edmonton, Canada.
Baker
G B
GB
Coutts
R T
RT
D000818:Animals; D001679:Biogenic Amines / Q000032:analysis*; D001923:Brain Chemistry / Q000187:drug effects*; D004298:Dopamine / Q000032:analysis; D008297:Male; D008995:Monoamine Oxidase / Q000032:analysis; D010627:Phenethylamines / Q000032:analysis / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis / Q000652:urine; D013997:Time Factors; D014191:Tranylcypromine / Q000032:analysis / Q000494:pharmacology*; D014363:Tryptamines / Q000032:analysis / Q000652:urine
D001679:Biogenic Amines; D010627:Phenethylamines; D014363:Tryptamines; C029261:phenethylamine; D012701:Serotonin; D014191:Tranylcypromine; C030820:tryptamine; D008995:Monoamine Oxidase; D004298:Dopamine