Effect of maternal selenium deficiency on the teratogenicity of methylmercury.
The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 mumol/kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and selenium-sufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestational period for an MMC-induced cleft palate.
Nishikido
N
N
Department of Public Health, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Satoh
Y
Y
Naganuma
A
A
Imura
N
N
D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005865:Gestational Age; D008431:Maternal-Fetal Exchange; D008767:Methylmercury Compounds / Q000032:analysis / Q000633:toxicity*; D051379:Mice; D011247:Pregnancy; D012643:Selenium / Q000032:analysis / Q000172:deficiency* / Q000502:physiology
D008767:Methylmercury Compounds; D012643:Selenium