title: Tuberculous pericarditis: ten year experience with a prospective protocol for diagnosis and treatment.
abstract: Thirteen patients with tuberculous pericarditis (12 men and 1 woman aged 13 to 70 years [mean 41]) were identified in a group of 294 patients consecutively admitted for primary acute pericardial disease. The diagnosis was made by the following studies: sputum culture (n = 4), culture of pericardial fluid obtained by pericardiocentesis (n = 3), histologic study and culture of pericardial biopsy (n = 3), lymph node biopsy (n = 2) and pleural biopsy (n = 1). Clinical presentation was remarkably variable: four patients had an acute, apparently self-limited course, one had relapsing tamponade, four had tamponade effectively treated with pericardiocentesis and four had toxic symptoms with persistent fever. The interval from hospital admission to diagnosis ranged from 1 to 14 weeks (mean 5.2). Constrictive pericarditis developed in six patients and effusive-constrictive pericarditis in one; all seven required pericardiectomy 2 to 3.5 months after admission. No patient died. It is concluded that 1) tuberculous pericarditis has a variable clinical presentation and therefore it should be considered in the evaluation of all instances of pericarditis without a rapidly self-limited course; 2) the diagnosis should be based only on objective data obtained with a systematic study protocol; 3) early definitive diagnosis is still difficult to achieve; and 4) development of subacute constrictive pericarditis requiring pericardiectomy is common.
authors.affiliation: Departamento de Medicina, Hospital General Vall d'Hebron, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Sagristà-Sauleda
authors.forename: G
authors.initials: G
authors.lastname: Permanyer-Miralda
authors.forename: J
authors.initials: J
authors.lastname: Soler-Soler
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009170:Nontuberculous Mycobacteria / Q000302:isolation & purification; D010495:Pericarditis, Tuberculous / Q000175:diagnosis* / Q000188:drug therapy; D010496:Pericardium / Q000382:microbiology; D011446:Prospective Studies; D013183:Sputum / Q000382:microbiology; D014381:Tuberculosis, Cardiovascular / Q000175:diagnosis*
chemical_list: D000995:Antitubercular Agents