title: Multiple-dose cimetidine administration does not influence the single-dose pharmacokinetics of quinapril and its active metabolite (CI-928).
abstract: The potential effect of cimetidine on the pharmacokinetic profiles of quinapril and its active metabolite CI-928 was evaluated in eight healthy volunteers. Each subject received a single 40-mg quinapril dose on days 1 and 12 and cimetidine 300 mg four times daily on days 8 through 13. Serial blood and urine samples were collected for assay of quinapril and CI-928 concentrations. No statistically significant differences were observed in quinapril or CI-928 Cmax, tmax, AUC(0-infinity), beta, or percent of dose excreted in urine values for quinapril administered alone and in combination with cimetidine. Therefore, multiple-dose cimetidine administration does not influence the single-dose pharmacokinetics of quinapril and its active metabolite, CI-928, in healthy volunteers.
authors.affiliation: Warner-Lambert/Parke-Davis, Pharmacokinetics-Drug Metabolism Department, Ann Arbor, Michigan.
authors.forename: J J
authors.initials: JJ
authors.lastname: Ferry
authors.forename: A B
authors.initials: AB
authors.lastname: Cetnarowski
authors.forename: A J
authors.initials: AJ
authors.lastname: Sedman
authors.forename: R W
authors.initials: RW
authors.lastname: Thomas
authors.forename: A M
authors.initials: AM
authors.lastname: Horvath
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000493:pharmacokinetics*; D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000493:pharmacokinetics*; D008297:Male; D000077583:Quinapril; D044005:Tetrahydroisoquinolines
chemical_list: D000959:Antihypertensive Agents; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C054501:quinaprilat; D002927:Cimetidine; D000077583:Quinapril