Spinal cord injury or spinal anesthesia eliminates seizures in myelin-deficient rats.
The generalized tonic seizures that occur in myelin-deficient rats can be eliminated temporarily by spinal cord injury or spinal anesthesia. These observations imply that the seizures in this mutant can be triggered by activity in the spinal cord. The results are consistent with an earlier proposal that axons in myelin-deficient CNS fiber tracts can interact to produce abnormal excitation.
Rosenbluth
J
J
Department of Physiology, New York University School of Medicine, NY 10016.
Hasegawa
M
M
D000775:Anesthesia, Spinal; D000818:Animals; D051379:Mice; D008818:Mice, Neurologic Mutants; D009186:Myelin Sheath / Q000502:physiology*; D012640:Seizures / Q000209:etiology / Q000503:physiopathology*; D013116:Spinal Cord / Q000503:physiopathology*