title: Effects of changes in infusion rate versus glucose concentration on absorption in infant miniature pig small intestine.
abstract: The effect of changes in the rate of infusion versus glucose concentration on glucose, water, and sodium absorption was studied in 20 infant miniature pigs using the single-pass small intestinal perfusion technique. During infusions of glucose loads of up to 75.0 mumol/min, glucose absorption increased similarly whether rate of infusion or glucose concentration was increased. Beyond 75.0 mumol/min, glucose absorption was not altered by changes in infusion rate, but was enhanced by increases in glucose concentration (slope of rate vs. concentration, p less than 0.0001). Net water and sodium absorption were similar in the two groups except for a decrease at the highest glucose concentration (rate vs. concentration at 187.5 mumol/min, p less than 0.05). A glucose concentration of 112.5 mM resulted in maximal glucose, water, and sodium absorption.
authors.affiliation: United States Department of Agriculture, Agricultural Research Service Children's Nutrition Research Center, Houston, Texas.
authors.forename: R J
authors.initials: RJ
authors.lastname: Shulman
authors.forename: C H
authors.initials: CH
authors.lastname: Lifschitz
mesh_terms: D000818:Animals; D005947:Glucose / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000378:metabolism*; D013552:Swine; D013556:Swine, Miniature
chemical_list: D005947:Glucose