title: Anticoagulation in patients with valvular heart disease, atrial fibrillation, or both.
abstract: Despite the availability of anticoagulant drugs for many years, there are still controversies regarding their use in many cardiovascular conditions. In this article, the pharmacology of warfarin and heparin are reviewed, and the clinical applications of these therapies in patients with valvular heart disease, atrial fibrillation, or both, discussed.
authors.affiliation: Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.
authors.forename: S L
authors.initials: SL
authors.lastname: Kadish
authors.forename: E J
authors.initials: EJ
authors.lastname: Lazar
authors.forename: W H
authors.initials: WH
authors.lastname: Frishman
mesh_terms: D001281:Atrial Fibrillation / Q000188:drug therapy*; D001705:Bioprosthesis; D006349:Heart Valve Diseases / Q000188:drug therapy*; D006350:Heart Valve Prosthesis; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D012307:Risk Factors; D013923:Thromboembolism / Q000517:prevention & control*; D014859:Warfarin / Q000627:therapeutic use*
chemical_list: D014859:Warfarin; D006493:Heparin