title: Improvement of differential toxicity between tumor and normal tissues using intratumoral injection with or without a slow-drug-release matrix system.
abstract: The therapeutic effects of cisplatin on tumor and normal tissues were assessed when the drug was given by different administration routes either as free drug or associated with a collagen-based matrix. Tumor response was assessed by growth delay of the murine RIF1 tumor, grown subcutaneously in female C3H/km mice. Normal tissue responses were assessed by plasma clearance of [51Cr]EDTA (giving an estimate of kidney damage), by the drop in peripheral white blood cells, and by a loss in mouse body weight. Intraperitoneal injections of cisplatin were the most toxic to the normal tissues for a given drug dose. Intratumoral injections of matrix-associated drug were the least toxic. Comparison of tumor growth delays for a given normal tissue damage demonstrated the superiority of all intratumoral schedules over the ip route.
authors.affiliation: Department of Experimental Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoekhuis, Amsterdam.
authors.forename: A C
authors.initials: AC
authors.lastname: Begg
authors.forename: H
authors.initials: H
authors.lastname: Bartelink
authors.forename: F A
authors.initials: FA
authors.lastname: Stewart
authors.forename: D M
authors.initials: DM
authors.lastname: Brown
authors.forename: E E
authors.initials: EE
authors.lastname: Luck
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage* / Q000633:toxicity; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004343:Drug Implants; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000188:drug therapy*
chemical_list: D003692:Delayed-Action Preparations; D004343:Drug Implants; D002945:Cisplatin; D004837:Epinephrine