Eosinophil-induced neurotoxicity: axonal neuropathy, cerebral infarction, and dementia.
Although beneficial in allergic and parasitic disease, eosinophils exert nonspecific toxic effects upon host tissues, especially the central and peripheral nervous systems. Eosinophil-induced neurotoxicity is characterized by axonal neuropathy, cerebral infarction, and dementia. Eosinophil-derived cytotoxic proteins are fundamental to the pathogenesis of this disorder.
Weaver
D F
DF
Department of Neurology, Dalhousie University, Halifax, Nova Scotia, Canada.
Heffernan
L P
LP
Purdy
R A
RA
Ing
V W
VW
D000328:Adult; D001369:Axons / Q000648:ultrastructure*; D002544:Cerebral Infarction / Q000209:etiology*; D003704:Dementia / Q000209:etiology*; D004802:Eosinophilia / Q000150:complications; D004804:Eosinophils / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology* / Q000473:pathology