title: Amoxapine cardiotoxicity.
abstract: Prolongation of the QRS interval, cardiopulmonary arrest, and death in a 31-year-old woman following an overdose of 2 g amoxapine, a tricyclic antidepressant, is reported. The patient's QRS interval prolonged to beyond 100 ms throughout hospitalization. Thirty-three hours after admission she suffered a bradycardiac-hypotensive event, followed by electromechanical dissociation and subsequent death. Cardiotoxicity has not been directly related to amoxapine; a 2-g acute ingestion is the lowest reported lethal dose.
authors.affiliation: Division of Cardiology, University Hospitals of Cleveland, School of Medicine, Case Western Reserve University, Ohio 44106.
authors.forename: M A
authors.initials: MA
authors.lastname: Munger
authors.forename: B A
authors.initials: BA
authors.lastname: Effron
mesh_terms: D000328:Adult; D000657:Amoxapine / Q000506:poisoning*; D003989:Dibenzoxazepines / Q000506:poisoning*; D004562:Electrocardiography; D004630:Emergencies; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D013610:Tachycardia / Q000139:chemically induced / Q000503:physiopathology
chemical_list: D003989:Dibenzoxazepines; D000657:Amoxapine