Rare Ha-ras and c-mos alleles in patients with intracranial tumors.
The occurrence of rare hypervariable Ha-ras alleles or of a rare c-mos allele in white blood cell DNA is claimed to be associated with susceptibility to cancer. We analyzed a group of patients with intracranial tumors to determine whether the occurrence of rare alleles at the Ha-ras locus and at the c-mos locus was increased in comparison with normal individuals. We found a higher incidence of rare hypervariable Ha-ras alleles (9.5% to 3%) and a 5 kilobase EcoRI c-mos allele (2.5% to 0%) in the patients. These results are consistent with the opinion that such unusual alleles are associated with a predisposition to intracranial tumors.
Diedrich
U
U
University Neurology Clinic, Göttingen, West Germany.
Eckermann
O
O
Schmidtke
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004912:Erythrocytes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009857:Oncogenes
D004247:DNA