title: The timing of tourniquet application in relation to prophylactic antibiotic administration.
abstract: Antibiotic levels in bone and fat were measured in patients undergoing knee replacement to determine the time that should elapse between intravenous injection and tourniquet inflation. The tissue levels increased progressively with time, and there was wide variation in absorption rate between patients and between the two cephalosporins assessed. Five minutes should probably be left between systemic injection and inflation of the tourniquet, though two minutes may be long enough for drugs which are rapidly absorbed.
authors.affiliation: Winford Orthopaedic Hospital, Bristol, England.
authors.forename: G C
authors.initials: GC
authors.lastname: Bannister
authors.forename: J M
authors.initials: JM
authors.lastname: Auchincloss
authors.forename: D P
authors.initials: DP
authors.lastname: Johnson
authors.forename: J H
authors.initials: JH
authors.lastname: Newman
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000032:analysis; D006801:Humans; D007720:Knee Prosthesis; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000517:prevention & control*; D013997:Time Factors; D014111:Tourniquets
chemical_list: D000900:Anti-Bacterial Agents