title: Synthetic trypanocides: growth-inhibiting properties of new 1,2,3,4-tetrahydrocarbazoles on Trypanosoma cruzi.
abstract: Several new 1,2,3,4-tetrahydrocarbazole, 5,6-dihydrobenzo(alpha) carbazole, 3-methylindole and substituted benzimidazolyl compounds were synthesized and assayed for their action on growth of Trypanosoma cruzi, cultured in Warren's liquid medium. 6-chloro and 6,8-dichloro-N-(1-ethyl-N-diethylamino)-1,2,3,4-tetrahydrocarbazole++ fumarate resulted the more active in inhibiting growth of the parasite. The new compounds were apparently more effective than those prepared previously by Poliakoff et al. (5).
authors.affiliation: Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
authors.forename: S M
authors.initials: SM
authors.lastname: Albónico
authors.forename: M E
authors.initials: ME
authors.lastname: Assem
authors.forename: I A
authors.initials: IA
authors.lastname: Benages
authors.forename: A A
authors.initials: AA
authors.lastname: Montiel
authors.forename: M T
authors.initials: MT
authors.lastname: Pizzorno
authors.forename: R
authors.initials: R
authors.lastname: Docampo
authors.forename: A O
authors.initials: AO
authors.lastname: Stoppani
mesh_terms: D000818:Animals; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
chemical_list: D002227:Carbazoles; D014344:Trypanocidal Agents