In vitro evaluation of DuP 105 and DuP 721, two new oxazolidinone antimicrobial agents.
DuP 105 and DuP 721 are two members of the oxazolidinones, a new class of synthetic antimicrobial agents with activity against gram-positive bacteria. In vitro tests compared the two new drugs with five other antimicrobial agents against 216 gram-positive isolates representing 4 genera and 10 species. DuP 721 MICs for 50% of the strains tested (MIC50s) ranged from 2.0 to 8.0 micrograms/ml, DuP 105 MIC50S ranged from 4.0 to 16 micrograms/ml, and vancomycin MIC50S ranged from 0.25 to 1.0 microgram/ml. Methicillin-resistant and -susceptible staphylococci were susceptible to ciprofloxacin, vancomycin, and DuP 721.
Barry
A L
AL
Clinical Microbiology Institute, Tualatin, Oregon 97062.
D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002433:Cefaclor / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D002939:Ciprofloxacin / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D010080:Oxazoles / Q000494:pharmacology*; D023303:Oxazolidinones; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010080:Oxazoles; D023303:Oxazolidinones; C054755:4-acetylphenyloxooxazolidinylmethylacetamide; D002939:Ciprofloxacin; D004917:Erythromycin; D002433:Cefaclor; D014640:Vancomycin; D000667:Ampicillin; C054753:4-methylsulfinylphenyloxooxazolidinylmethylacetamide