title: Cholecystokinin antagonists. Synthesis and biological evaluation of 3-substituted 1,4-benzodiazepin-2-amines.
authors.affiliation: Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486.
authors.forename: M G
authors.initials: MG
authors.lastname: Bock
authors.forename: R M
authors.initials: RM
authors.lastname: DiPardo
authors.forename: B E
authors.initials: BE
authors.lastname: Evans
authors.forename: K E
authors.initials: KE
authors.lastname: Rittle
authors.forename: R M
authors.initials: RM
authors.lastname: Freidinger
authors.forename: R S
authors.initials: RS
authors.lastname: Chang
authors.forename: V J
authors.initials: VJ
authors.lastname: Lotti
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D002540:Cerebral Cortex / Q000378:metabolism; D002766:Cholecystokinin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006168:Guinea Pigs; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D011949:Receptors, Cholecystokinin / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D007202:Indicators and Reagents; D011949:Receptors, Cholecystokinin; D001569:Benzodiazepines; D002766:Cholecystokinin