title: Dietary restriction, cell proliferation and carcinogenesis: a preliminary study.
abstract: Four groups of female Swiss Webster mice were given either laboratory chow or a purified (semi-synthetic) diet (AIN-76A) either ad libitum or at 75% of the ad libitum rate for about 30 days. Three tissues, the crypt cells of the jejunum, the dermis and the basal epithelial cells of the esophagus were investigated using [3H]thymidine labelling and by counting mitoses; four other tissues, the alveolar cells of the mammary gland, the crypt cells of the duodenum and colo-rectum, and the transitional cells of the urinary bladder were examined using [3H]thymidine labelling only. In each case dietary restriction led to a reduction of cellular proliferation assessed by these indices. The potential of the approach for the study of the effects of dietary modification on the induction of cancer is discussed.
authors.affiliation: Toxicology Research Division, Bureau of Chemical Safety, Health & Welfare, Canada, Ottawa, Ontario.
authors.forename: E
authors.initials: E
authors.lastname: Lok
authors.forename: E A
authors.initials: EA
authors.lastname: Nera
authors.forename: F
authors.initials: F
authors.lastname: Iverson
authors.forename: F
authors.initials: F
authors.lastname: Scott
authors.forename: Y
authors.initials: Y
authors.lastname: So
authors.forename: D B
authors.initials: DB
authors.lastname: Clayson
mesh_terms: D000818:Animals; D002455:Cell Division; D004038:Diet, Reducing; D005260:Female; D051379:Mice; D009374:Neoplasms, Experimental / Q000209:etiology*; D013936:Thymidine / Q000378:metabolism
chemical_list: D013936:Thymidine