title: [A case of bronchial carcinoma showing regression upon intratumoral administration of OK-432].
abstract: A 38-year-old female suffering from chronic respiratory symptoms due to lung cancer occupying the left main bronchus was treated by frequent intratumoral injections of OK-432. The immune-modifying therapy was performed as follows; 0.2 KE of OK-432 was injected intracutaneously once a week, then the dose was gradually increased to 3.0 KE once a week. Following immunization, intratumoral injection was done under endoscopy at a dose of 3.0 KE every two weeks. Three months later, the tumor showed remarkable regression, and clinical symptoms were diminished. In conclusion, intratumoral injection of OK-432 was considered to be very beneficial in lung cancer.
authors.affiliation: 2nd Dept. of Internal Medicine, School of Medicine, University of Akita.
authors.forename: A
authors.initials: A
authors.lastname: Onodera
authors.forename: K
authors.initials: K
authors.lastname: Miura
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: N
authors.initials: N
authors.lastname: Sugiyama
authors.forename: H
authors.initials: H
authors.lastname: Kurokawa
authors.forename: T
authors.initials: T
authors.lastname: Shioya
authors.forename: T
authors.initials: T
authors.lastname: Kanazawa
mesh_terms: D000328:Adult; D001688:Biological Products / Q000008:administration & dosage*; D001984:Bronchial Neoplasms / Q000628:therapy*; D001999:Bronchoscopy; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D005260:Female; D006801:Humans; D010844:Picibanil / Q000008:administration & dosage* / Q000627:therapeutic use; D012074:Remission Induction
chemical_list: D001688:Biological Products; D010844:Picibanil