Neuropsychiatric consequences of AIDS.
As part of a study in progress, neuropsychological tests have been administered to 13 patients with clinical acquired immunodeficiency syndrome, 9 human immunodeficiency virus-seropositive patients, 4 seropositive patients with chronic active hepatitis, 5 seronegative patients with chronic active hepatitis, and 6 healthy controls. Consistent with findings in earlier patient and control groups, the acquired immunodeficiency syndrome patients had substantially lower scores on a variety of cognitive tests. Although the acquired immunodeficiency syndrome group is not education-matched at present, the results are nonetheless consistent with impairments of language function and timed, self-paced performance. Test results obtained may reflect focal and global cognitive impairment as well as motivational decrements in patients with the acquired immunodeficiency syndrome relative to seropositive patients or controls.
Rubinow
D R
DR
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892.
Berrettini
C H
CH
Brouwers
P
P
Lane
H C
HC
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000704:Analysis of Variance; D001927:Brain Diseases / Q000150:complications*; D006679:HIV Seropositivity; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications*; D009483:Neuropsychological Tests; D012016:Reference Values