title: Hollow implants in soft tissues allowing quantitative studies of cells and fluid at the implant interface.
abstract: In order to study the early cellular response in the fluid phase found close to implants in soft tissues, an experimental method using a hollow implant was developed. The fluid present in an interior chamber communicating with the exterior of the implant was analysed. Polymorphonuclear granulocytes (PMNGs) were predominant during the study (1-9 days). In titanium implants a slight increase in cell numbers with time was noted, whereas in polytetrafluoroethylene (PTFE) implants, a sharp increase in cell numbers was observed. Preliminary studies showed that sufficient amounts of fluid and cells could be retrieved for analysis of protein composition and inflammatory cell activation.
authors.affiliation: Department of Anatomy, University of Gothenburg, Sweden.
authors.forename: A S
authors.initials: AS
authors.lastname: Eriksson
authors.forename: L M
authors.initials: LM
authors.lastname: Bjursten
authors.forename: L E
authors.initials: LE
authors.lastname: Ericson
authors.forename: P
authors.initials: P
authors.lastname: Thomsen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D005122:Exudates and Transudates / Q000473:pathology; D007249:Inflammation / Q000209:etiology / Q000473:pathology; D007700:Kinetics; D007958:Leukocyte Count; D007962:Leukocytes; D008297:Male; D009504:Neutrophils; D011138:Polytetrafluoroethylene; D019736:Prostheses and Implants / Q000009:adverse effects; D051381:Rats; D011919:Rats, Inbred Strains; D014025:Titanium
chemical_list: D001672:Biocompatible Materials; D011138:Polytetrafluoroethylene; D014025:Titanium