Sch 37137, a novel antifungal compound produced by a Micromonospora sp. Taxonomy, fermentation, isolation, structure and biological properties.
A new antifungal compound, Sch 37137, was isolated from the cultured broth of a Micromonospora sp., SCC 1792. Sch 37137 is structurally related to A 19009, a dipeptide previously discovered from a Streptomyces sp. The compound was weakly active against species of Candida and dermatophytes (mean MICs greater than or equal to 128 micrograms/ml) in Sabouraud dextrose, yeast-nitrogen and modified Eagles minimum essential media; however activity against Candida sp. (mean MICs greater than or equal to 12 micrograms/ml) and dermatophytes (mean MICs greater than or equal to 0.8 microgram/ml) significantly improved in MA medium.
Cooper
R
R
Pharmaceutical Research Division, Schering Plough Corporation, Bloomfield, New Jersey 07003.
Horan
A C
AC
Gentile
F
F
Gullo
V
V
Loebenberg
D
D
Marquez
J
J
Patel
M
M
Puar
M S
MS
Truumees
I
I
D000599:Amino Acids, Diamino / Q000096:biosynthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D008847:Micromonospora / Q000378:metabolism*
D000599:Amino Acids, Diamino; D000935:Antifungal Agents; C055110:N-L-alanyl-3-(((3-(aminocarbonyl)oxiranyl)carbonyl)amino)-L-alanine