Family size limitation: a method for demonstrating recessive inheritance.
Limitation of family size after the birth of a child with a serious disorder poses a problem in demonstrating autosomal recessive inheritance. In this paper methods are presented for distinguishing autosomal recessive inheritance given a 100% deterrent effect, and revealing a partial deterrent effect by analysis of sibship size and comparison with general population data. These methods are illustrated using information from phenylketonuria families.
Brookfield
J F
JF
Department of Genetics, University of Leicester.
Pollitt
R J
RJ
Young
I D
ID
D005193:Family Planning Services; D005808:Genes, Recessive; D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D010375:Pedigree; D010661:Phenylketonurias / Q000235:genetics*