A first approach to an action spectrum for 8-MOP phototumorigenesis in mice.
Groups of hairless albino mice were treated with 8-MOP and exposed to a fixed daily dose of UVR obtained from one of four different emission spectra. Each spectrum was obtained by filtering a xenon arc source with a different WG filter. The resultant spectra showed differences in their proportions of shorter UVA wavelengths. A decreased proportion of the shorter wave bands systematically increased the time to first tumor. These data suggest that the action spectrum for 8-MOP sensitized phototumorigenesis is similar to that of acute 8-MOP action spectra in mammalian skin, which usually show maximal activity in the 320-335 nm region.
Young
A R
AR
Department of Photobiology, United Medical School, Guy's Hospital, London, England.
Walker
S L
SL
Garmyn
M
M
D000818:Animals; D004247:DNA / Q000378:metabolism; D005260:Female; D008730:Methoxsalen / Q000378:metabolism / Q000633:toxicity*; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D014466:Ultraviolet Rays / Q000009:adverse effects*
D004247:DNA; D008730:Methoxsalen