title: Efficacy of the morantel sustained-release bolus in grazing cattle in North America.
abstract: The efficacy of using a bolus containing morantel in a sustained-release preparation for controlling naturally acquired gastrointestinal parasitic infections in weaned calves and yearling cattle was investigated during the 1982 grazing season at selected sites in the United States and Canada. According to a common trial design under various climatic and management conditions, 10 field trials were conducted with the bolus. At the time of spring turnout, a bolus was administered to each calf or yearling in the treated group. Then, treated and control cattle grazed separate but equal areas of divided pasture(s). The epidemiologic pattern of parasitic gastroenteritis in control animals and the effect of treatment on this pattern was determined in each trial. Safety and practicality of use of the bolus also were established. When compared with untreated cattle (control), those given the bolus deposited significantly (P less than 0.05) fewer worm eggs (89% reduction) during the first 90 days of the grazing season, as well as significantly fewer (P less than 0.05) worm eggs (84% reduction) during the entire grazing season. Consequently, during the second half of the grazing season, larval populations on treated pastures remained significantly (P less than 0.05) lower (66% reduction), compared with numbers of larvae found on control pastures. For pastures grazed by treated and control cattle at trial initiation, mean worm counts recovered from tracer calves were equal, indicating comparable pasture contamination at the beginning of the grazing season.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Pfizer Inc Central Research, Terre Haute, IN 47808.
authors.forename: D H
authors.initials: DH
authors.lastname: Bliss
authors.forename: T J
authors.initials: TJ
authors.lastname: Newby
mesh_terms: D000818:Animals; D001835:Body Weight; D002170:Canada; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000517:prevention & control*; D003692:Delayed-Action Preparations; D005243:Feces / Q000469:parasitology; D006373:Helminthiasis / Q000188:drug therapy / Q000517:prevention & control; D006374:Helminthiasis, Animal; D006376:Helminths / Q000254:growth & development; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D007814:Larva; D009015:Morantel / Q000008:administration & dosage / Q000627:therapeutic use*; D010270:Parasite Egg Count / Q000662:veterinary; D011743:Pyrimidines / Q000627:therapeutic use*; D014481:United States
chemical_list: D003692:Delayed-Action Preparations; D011743:Pyrimidines; D009015:Morantel