Mood effects of alternate-day corticosteroid therapy in patients with systemic lupus erythematosus.
Mood and cognition were assessed on consecutive days in 18 female patients with systemic lupus erythematosus on alternate-day corticosteroid therapy. No overall differences in mood and cognition were observed between the on- and off-medication days. However, 10 patients showed marked worsening or improvement of either depression or anxiety on their off-medication day. Two weeks of prospective behavioral ratings confirmed the observed mood changes in several patients. The clinical and theoretical implications of these findings are discussed.
Joffe
R T
RT
Department of Psychiatry, St. Michael's Hospital.
Denicoff
K D
KD
Rubinow
D R
DR
Tsokos
G
G
Balow
J E
JE
Pillemer
S E
SE
D000328:Adult; D001008:Anxiety Disorders / Q000139:chemically induced*; D003072:Cognition Disorders / Q000139:chemically induced; D003866:Depressive Disorder / Q000139:chemically induced*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000523:psychology; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects*
D011241:Prednisone