title: Retraction of bioprosthetic heart valve cusps: a cause of wide-open regurgitation in right-sided heart valves.
abstract: Most failures of bioprosthetic heart valves in children are due to stenosis secondary to thrombus, calcific deposits, or tissue ingrowth. Valve failures due to regurgitation typically involve cuspal detachment, tears, or perforations. We present four cases of prosthetic valve regurgitation in children caused by cuspal retraction without stenosis and describe the morphologic findings related to the valves at autopsy or explantation. A mononuclear cell and giant cell response to the cusps of the valve was a striking finding in one patient.
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105.
authors.forename: S K
authors.initials: SK
authors.lastname: Murphy
authors.forename: W C
authors.initials: WC
authors.lastname: Rogler
authors.forename: W H
authors.initials: WH
authors.lastname: Fleming
authors.forename: B M
authors.initials: BM
authors.lastname: McManus
mesh_terms: D000293:Adolescent; D001705:Bioprosthesis; D002648:Child; D005260:Female; D006349:Heart Valve Diseases / Q000473:pathology*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D014261:Tricuspid Valve / Q000473:pathology