Effect of capsaicin pretreatment on capsaicin-induced catecholamine secretion from the adrenal medulla in rats.
The effect of capsaicin pretreatment on adrenal catecholamine secretion induced by intravenously administered capsaicin was investigated in alpha-chloralose and urethane anesthetized rats. In neonatal vehicle pretreated rats, capsaicin (200 micrograms/kg, iv) caused a rapid and significant increase in adrenal epinephrine secretion, but neonatal capsaicin pretreatment (50 mg/kg, sc, on the 2nd day of life) significantly reduced both the basal and capsaicin-induced epinephrine secretion from the adrenal medulla. Adult capsaicin pretreatment (6 increasing doses/6 days, total 310 mg/kg, sc) also reduced both the basal and capsaicin-stimulated adrenal epinephrine secretion, though it was less effective compared with the neonatal capsaicin pretreatment. These results suggest the participation of capsaicin-sensitive neurons in capsaicin-induced catecholamine secretion from the adrenal medulla.
Watanabe
T
T
Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan.
Kawada
T
T
Iwai
K
K
D000313:Adrenal Medulla / Q000187:drug effects / Q000378:metabolism*; D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D002211:Capsaicin / Q000008:administration & dosage* / Q000494:pharmacology; D002395:Catecholamines / Q000378:metabolism*; D008297:Male; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains
D002395:Catecholamines; D002211:Capsaicin