title: Resistant hypertension. Introduction and definitions.
abstract: The following definition of resistant hypertension is proposed: Provided that adherence to the regimen can be assured, hypertension should be considered resistant if the blood pressure cannot be reduced to less than 150/100 mm Hg by a rational triple drug regimen, including a diuretic, prescribed in nearly maximal doses and if the pretreatment blood pressure was greater than or equal to 180/115 mm Hg. If the pretreatment blood pressure was less than 180/115 mm Hg, resistance should be defined as failure to achieve normotension (less than 140/90 mm Hg) on a rational triple drug regimen in nearly maximal doses.
authors.affiliation: Department of Hypertension and Nephrology, Cleveland Clinic Foundation, OH 44106.
authors.forename: R W
authors.initials: RW
authors.lastname: Gifford
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000145:classification* / Q000188:drug therapy; D010349:Patient Compliance
chemical_list: D000959:Antihypertensive Agents