Topical application of human fibroblast interferon (IFN) in cutaneous leishmaniasis.
Fifteen patients with single or multiple lesions of cutaneous leishmaniasis were randomly assigned to apply either IFN-beta-containing cream or a placebo cream base. Despite 8 weeks of therapy no significant improvement of the lesions was achieved. Although topical IFN-beta was not effective in this study, several laboratory studies suggest that IFN, particularly IFN-gamma, may be of therapeutic value in cutaneous leishmaniasis.
Trau
H
H
Department of Dermatology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Schewach-Millet
M
M
Shoham
J
J
Doerner
T
T
Shor
R
R
Passwell
J H
JH
D000287:Administration, Topical; D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage / Q000627:therapeutic use*; D007896:Leishmaniasis / Q000628:therapy*; D008297:Male; D011897:Random Allocation
D007370:Interferon Type I