An inherited albumin variant with enhanced affinity for the Amerlex thyroxin-analog.
We describe two siblings with artefactually increased results for free thyroxin in serum as measured with the Amerlex analog method, despite normal thyroxin transport. The cause of the artefact is identified as a variant albumin with enhanced affinity for the Amerlex thyroxin-analog.
France
N C
NC
Department of Pathology, Waikato Hospital, Hamilton, New Zealand.
Speed
J F
JF
Conaglen
J V
JV
D001796:Blood Protein Disorders / Q000097:blood / Q000235:genetics; D002648:Child; D005189:False Positive Reactions; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D011485:Protein Binding; D011863:Radioimmunoassay; D011933:Reagent Kits, Diagnostic; D012709:Serum Albumin / Q000235:genetics* / Q000378:metabolism; D013974:Thyroxine / Q000097:blood*
D011933:Reagent Kits, Diagnostic; D012709:Serum Albumin; D013974:Thyroxine