A tissue-specific endothelial cell molecule involved in lymphocyte homing.
An endothelial cell surface molecule that is selectively expressed in mucosal organs is required for lymphocyte homing to mucosal lymphoid tissues. This 'vascular addressin' appears to function as a tissue-specific marker or address signal for recognition by lymphocytes circulating in the blood.
Streeter
P R
PR
Department of Pathology, Stanford University School of Medicine, California 94305.
Berg
E L
EL
Rouse
B T
BT
Bargatze
R F
RF
Butcher
E C
EC
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface; D015820:Cadherins; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules; D002465:Cell Movement; D004730:Endothelium, Vascular / Q000032:analysis* / Q000276:immunology; D008198:Lymph Nodes / Q000378:metabolism; D008214:Lymphocytes / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000276:immunology / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009928:Organ Specificity; D010581:Peyer's Patches / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D015820:Cadherins; C489083:Cdh2 protein, mouse; D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins