Amino acid metabolism in tumour-bearing mice.
Mice bearing the Lewis lung carcinoma showed a high tumour glutaminase activity and significantly higher concentrations of most amino acids than in both the liver and the skeletal muscle of the host. Tumour tissue slices showed a marked preference for glutamine, especially for oxidation of its skeleton to CO2. It is proposed that the metabolism of this particular carcinoma is focused on amino acid degradation, glutamine being its preferred substrate.
Rivera
S
S
Department de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Spain.
Azcón-Bieto
J
J
López-Soriano
F J
FJ
Miralpeix
M
M
Argilés
J M
JM
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D005972:Glutaminase / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008175:Lung Neoplasms / Q000201:enzymology / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009132:Muscles / Q000378:metabolism; D009368:Neoplasm Transplantation; D011506:Proteins / Q000378:metabolism
D000596:Amino Acids; D011506:Proteins; D005972:Glutaminase; D005947:Glucose