title: [Bihormonal apudoma of the pancreas].
abstract: A pancreatic tumor that displayed bihormonal activity is described: the tumor elaborated insulin, resulting in a hyperinsulinism syndrome (spontaneous hypoglycemia) as well as a second hormone, apparently gastrin or a gastrin-like polypeptide, which led to the development of Zollinger-Ellison syndrome. The presence of these two syndromes complicated both the diagnosis and treatment of the disease. A histologic examination using an argyrophilic (Grimelius) reaction confirmed that the tumor had originated from endocrine cells of the gastrointestinal tract and was a bihormonal apudoma of the pancreas.
authors.forename: G S
authors.initials: GS
authors.lastname: Konstantinov
mesh_terms: D001079:Apudoma / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005755:Gastrins / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D005755:Gastrins; D007328:Insulin
vernacular_title: Bigormonal'naia apudoma podzheludochnoĭ zhelezy.