title: Selection of the optimal lesion site for the relief of parkinsonian tremor on the basis of spectral analysis of neuronal firing patterns.
abstract: Techniques for quantitatively describing the firing properties of neurons have been used to identify thalamic cells with a firing pattern which is correlated with EMG activity during tremor. By locating these cells relative to the anterior border of the somatosensory nucleus and the anterior commissure-posterior commissure line, it may be possible to select the optimal lesion site for the relief of parkinsonian tremor on a rational rather than an empirical basis.
authors.affiliation: Division of Neurosurgery, University of Toronto, Ont., Canada.
authors.forename: F A
authors.initials: FA
authors.lastname: Lenz
authors.forename: R R
authors.initials: RR
authors.lastname: Tasker
authors.forename: H C
authors.initials: HC
authors.lastname: Kwan
authors.forename: S
authors.initials: S
authors.lastname: Schider
authors.forename: R
authors.initials: R
authors.lastname: Kwong
authors.forename: J O
authors.initials: JO
authors.lastname: Dostrovsky
authors.forename: J T
authors.initials: JT
authors.lastname: Murphy
mesh_terms: D006801:Humans; D009474:Neurons / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology / Q000601:surgery*; D013238:Stereotaxic Techniques; D013788:Thalamus / Q000166:cytology / Q000601:surgery*; D014202:Tremor / Q000503:physiopathology / Q000601:surgery*