title: Enhancement of the delayed-type hypersensitivity reaction by oxazaphosphorines.
abstract: Delayed hypersensitivity reactions include tuberculin type, Jones Mote type reactions and contact sensitivity. These reactions are increased in guinea pigs and other species by pretreating the animals with a single dose of up to 300 mg/kg cyclophosphamide (CY). CY also reverses immunological tolerance and other forms of immunological unresponsiveness, including antigenic competition. Regulation of these hypersensitivity responses may be controlled by CY-sensitive B- or T-suppressor cells, depending on the species and the model. CY does not appear to act by increasing IL-2 production in the same way as other anti-cancer agents.
authors.affiliation: Department of Pathology, Royal College of Surgeons of England, London.
authors.forename: J L
authors.initials: JL
authors.lastname: Turk
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D051379:Mice
chemical_list: D000276:Adjuvants, Immunologic; D003520:Cyclophosphamide