[Reye's syndrome].
Reye's syndrome, characterized by acute encephalopathy and fatty degeneration of the viscera with hepatic failure, is a life-threatening illness that affects children of all ages. Although Reye's syndrome has been investigated extensively, its etiology and pathogenesis remain obscure. Metabolic pathophysiology appears to include a process affecting liver mitochondria. Recently disturbances in fatty acid oxidation have been described with a similar clinical picture. The cause of these events is presumably related to triggering viral illnesses, in ways that are unclear. Since prompt treatment might provide a better chance for recovery, early diagnosis is important.
Berghuis
M
M
Afd. Algemene Intensive Care, Universiteitskliniek voor Kinderen en Jeugdigen, Het Wilhelmina Kinderziekenhuis, Utrecht.
van Vught
A J
AJ
de Klerk
J B
JB
Huber
J
J
D001927:Brain Diseases / Q000503:physiopathology; D002648:Child; D003422:Critical Care / Q000379:methods; D003937:Diagnosis, Differential; D004569:Electroencephalography; D006801:Humans; D007427:Intracranial Pressure; D008661:Metabolism, Inborn Errors / Q000175:diagnosis; D012202:Reye Syndrome / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy
Het syndroom van Reye.