[Cytogenetic course after allograft of bone marrow in chronic myeloid leukemia].
Bone marrow karyotyping was serially performed in 23 Ph1+ chronic myelocytic leukemia patients treated with allogeneic bone marrow transplantation (BMT). Two patients underwent 2 BMT each. Fifteen patients had only normal karyotypes and 8 patients (after 10 BMT) had either sporadic Ph1+ metaphases (6 cases) or cytogenetic signs of relapse (4 cases, of which in 1 case, without hematological symptoms), or both in succession. Sporadic Ph1+ metaphases were found early after BMT (never after the 6th month). Although they were more frequent in non-splenectomized patients than in others, there was no significant correlation between sporadic Ph1+ metaphases and disease features, treatment regimens or evolution after BMT.
Bernard
P
P
Service des Maladies du Sang, CHR Bordeaux, France.
Abdallah
A N
AN
Marit
G
G
David
B
B
Broustet
A
A
Reiffers
J
J
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D005260:Female; D006087:Graft vs Host Reaction; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000628:therapy; D008297:Male; D008938:Mitosis; D010677:Philadelphia Chromosome; D014184:Transplantation, Homologous
Evolution cytogénétique après allogreffe de moelle osseuse dans la leucémie myéloïde chronique.