title: [Sensitivity of the splenic cells of different mouse strains to the antiproliferative action of alkylating compounds].
abstract: A method of quantitative evaluation of lymphocytes' sensitivity to the antiproliferative effect of the alkylating drugs has been developed. Chlorbutin, mafosfamide (Asta Z 7654) and "active" metabolites of cyclophosphamide were studied. This research allowed to distinguish more sensitive strains (DBA/2 and C57BL/6) and those with low sensitivity (BALB/c and CC57BR). These differences do not depend on proliferation reaction, neither on the type of alkylating drugs nor haplotypes H-2.
authors.forename: A L
authors.initials: AL
authors.lastname: Pukhal'skiĭ
authors.forename: A P
authors.initials: AP
authors.lastname: Mezhneva
authors.forename: L A
authors.initials: LA
authors.lastname: Pevnitskiĭ
mesh_terms: D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002699:Chlorambucil / Q000494:pharmacology; D003520:Cyclophosphamide / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000494:pharmacology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005838:Genotype; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D013154:Spleen / Q000166:cytology / Q000187:drug effects*
chemical_list: D000477:Alkylating Agents; D002699:Chlorambucil; D003520:Cyclophosphamide; C047251:mafosfamide-lysine
vernacular_title: Chuvstvitel'nost' kletok selezenki mysheĭ raznykh liniĭ k antiproliferativnomu deĭstviiu alkiliruiushchikh soedineniĭ.