The role of plasma secretin during starvation in dogs.
Plasma secretin levels were measured during a 72-hour starvation period in dogs. Plasma secretin rose significantly and insulin levels fell significantly during starvation. Intravenous glucose loading at the end of the 72-hour starvation period suppressed plasma secretin and free fatty acid levels with a concomitant rise of glucose and insulin levels. These findings suggest that secretin might be regulated by plasma glucose and insulin levels and might play a role in lipolysis during starvation.
Manabe
T
T
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Tanaka
Y
Y
Yamaki
K
K
Asano
N
N
Nonaka
A
A
Hirano
T
T
Nishikawa
H
H
Tobe
T
T
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005950:Glucose Solution, Hypertonic; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood; D008297:Male; D012633:Secretin / Q000097:blood*; D013217:Starvation / Q000097:blood*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D005950:Glucose Solution, Hypertonic; D007328:Insulin; D012633:Secretin