[Intra-arterial chemotherapy of ovarian cancer using a subcutaneously embedded reservoir--a case showing remarkable response to intermittently repeated low-dose intra-arterial infusion chemotherapy].
By fitting a subcutaneously embedded reservoir to an aged patient with ovarian cancer in whom exploratory laparotomy was performed, we attempted intermittent intraarterial infusion chemotherapy using small doses of CDDP and ADM, and obtained favorable results. The catheter was inserted at an artery in the lower abdominal wall, attached at the site where the pointed end reached the upper margin of L3, and fixed to the fascia recta, connecting with the reservoir on the reverse side. As drug solutions, 5 mg of CDDP and 5 mg of ADM were transcutaneously infused twice per week. Results 1) A marked necrotic tendency was noted in the tumor, and retention of ascites was remarkably decreased. 2) Hardly any nausea and vomiting as side effects were noted, and decreases in leucocyte and platelet counts were mild, recovering rapidly due to dropout. 3) Anxiety regarding infection was minimal at times other than when the drug solution was being infused, and patient was able to take a bath. From the above-mentioned results, it was considered that maintenance chemotherapy on an outpatient basis using approximately one dose per week would be possible in the future for ovarian cancer.
Izawa
H
H
Dept. of Gynecology, Gunma Cancer Center.
Nomura
S
S
Inoue
H
H
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D007261:Infusions, Intra-Arterial; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology
D004317:Doxorubicin; D002945:Cisplatin