[Beneficial effects of the combination of antibiotics and immunomodulating lipopeptides].
Although antibiotics are efficient therapeutic weapons, their actions is limited in immunocompromised patients. The efficacy of immunomodulators which restore the immune system could be improved if they were associated to infra-active doses of antibiotics which prepare the bacteria to the immune system attack. Thus it seems possible to obtain a therapeutic gain with such an association and, consequently, to avoid the emergence of antibiotic-resistant germs.
Floc'h
F
F
Centre de Recherches de Vitry, Rhône-Poulenc Santé, Vitry-sur-Seine.
Poirier
J
J
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000667:Ampicillin / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003115:Colony-Stimulating Factors / Q000096:biosynthesis; D004359:Drug Therapy, Combination; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D007928:Lethal Dose 50; D008088:Listeriosis / Q000150:complications / Q000188:drug therapy*; D051379:Mice; D010455:Peptides / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D003115:Colony-Stimulating Factors; D010455:Peptides; D000667:Ampicillin
Effects bénéfiques de l'association antibiotiques et lipopeptides immunomodulateurs.