title: Propylthiouracil disposition in older hypothyroid patients.
abstract: The pharmacokinetic disposition of propylthiouracil (PTU) after a single oral dose was studied in 6 severely hypothyroid patients. Severity of disease, as indicated by thyroid-stimulating hormone concentration, was inversely related to plasma clearance of PTU. There were trends to increased apparent volume of distribution and plasma half-life for PTU as a function of age. The large apparent volume of distribution for PTU in these patients compared to euthyroid and hyperthyroid subjects, after a single drug dose, suggests that hypothyroidism as well as chronic drug ingestion must be considered as possible factors mediating this change.
authors.affiliation: Division of Clinical Pharmacology, Montreal General Hospital, Winnipeg, Canada.
authors.forename: D S
authors.initials: DS
authors.lastname: Sitar
authors.forename: A
authors.initials: A
authors.lastname: Abu-Bakare
authors.forename: R J
authors.initials: RJ
authors.lastname: Gardiner
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011441:Propylthiouracil / Q000493:pharmacokinetics*; D013960:Thyroid Function Tests
chemical_list: D011441:Propylthiouracil