title: [In vitro activity of imipenem (N-formimidoylthienamycin), a new carbapenem antibiotic].
abstract: Imipenem is a beta-lactam carbapenem antibiotic, N-formimidoyl thienamycin-derivate. Imipenem is highly active against gram-negative aerobes and also highly active against gram-positive aerobes and virtually all anaerobes, with MICs very low and MBCs equal or only two-four dilution higher, it has a low degree of affinity for all types of beta-lactamases, shown a good post-antibiotic effect, it is a potent inhibitor to peptidoglycan with a greatest affinity for PBP2 and PBP1, in gram-negative bacteria, and for PBP3, PBP1 and PBP4, in gram-positive bacteria. The precocious bactericidal activity belongs to its low molecular weight, the characteristic of zwitterionic compound, to its hydrophobicity and to, in finally, its compact molecular structure.
authors.affiliation: Istituto di Microbiologia, Torino.
authors.forename: R
authors.initials: R
authors.lastname: Cavallo
authors.forename: N A
authors.initials: NA
authors.lastname: Carlone
mesh_terms: D015378:Imipenem; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology*
chemical_list: D013845:Thienamycins; D015378:Imipenem
vernacular_title: Attività in vitro dell'imipenem (N-formimidoil tienamicina) un nuovo antibiotico carbapenemico.