Massive doses of midazolam infusion for delirium tremens without respiratory depression.
After undergoing replantation and revascularization surgery for a complex hand injury, a 25-yr-old male developed florid delirium tremens. Over a 5-day period, he received 2850 mg of midazolam as a constant infusion of varying rates. The midazolam controlled his severe agitation without respiratory depression and the hand reconstruction survived undamaged.
Lineaweaver
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Microsurgical Replantation Transplantation Department, Ralph K. Davies Medical Center, San Francisco, CA 94114.
Anderson
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Hing
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D000328:Adult; D000430:Alcohol Withdrawal Delirium / Q000188:drug therapy* / Q000209:etiology; D000673:Amputation, Traumatic / Q000601:surgery; D005383:Finger Injuries / Q000601:surgery*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008866:Microsurgery; D008874:Midazolam / Q000008:administration & dosage* / Q000009:adverse effects; D011183:Postoperative Complications / Q000188:drug therapy*; D011604:Psychoses, Alcoholic / Q000188:drug therapy*; D012092:Replantation; D012131:Respiratory Insufficiency / Q000139:chemically induced
D008874:Midazolam