title: [Molecular-genetic aspects of drug therapy of malignant tumors].
abstract: State and prospects of the drug cancer therapy are examined in the light of achievements of modern molecular oncology. Special attention is paid to the molecular genetic analysis of the appearance of individual and multiple cellular drug resistance in connection with amplification of definite genes as well as oncogenes. The idea about the possible role of oncogene activation as a universal cell reaction in response to an injury of environmental factors is advanced. It concerns both oncogenesis and induction of cancer cell drug resistance.
authors.forename: I F
authors.initials: IF
authors.lastname: Seĭts
mesh_terms: D000818:Animals; D004351:Drug Resistance; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D014407:Tumor Cells, Cultured / Q000187:drug effects
vernacular_title: Molekuliarno-geneticheskie aspekty lekarstvennoĭ terapii zlokachestvennykh opukholeĭ.