Effects of paternal alcohol consumption in mice.
Male mice were divided into four groups, one group was given ad libitum access to a liquid alcohol diet containing 35% ethanol derived calories (EDC). A second group was pair fed an isocaloric control diet containing 17.5% EDC whereas a third was similarly treated with a 0% EDC diet for a minimum of 42 days. A fourth group served as ad libitum nontreated controls to assess the role of pair feeding. Males were then mated with nontreated females. The males consuming alcohol had an increased percentage of abnormal sperm and there was a significant effect of paternal alcohol exposure on implantation sites, but no effect on pre- or postnatal mortality or fetal weight. These results suggest that paternal alcohol consumption adversely affects sperm production but does not affect development of offspring in mice.
Abel
E L
EL
Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan.
Moore
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D000818:Animals; D010064:Embryo Implantation / Q000187:drug effects; D005314:Embryonic and Fetal Development; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D007248:Infertility, Male / Q000139:chemically induced; D008297:Male; D051379:Mice; D013094:Spermatozoa / Q000002:abnormalities* / Q000187:drug effects
D000431:Ethanol