title: The importance of load-independent analysis in assessment of the inotropic effect of prostaglandin E1 in vivo.
abstract: Load-independent pressure-dimension analysis was applied in 13 open-chest, anesthetized dogs during either left atrial (n = 7) or right atrial (n = 6) infusion of prostaglandin E1. Right atrial infusion of prostaglandin E1 in doses from 31 to 500 ng/kg/min resulted in no change in any parameters studied, including mean arterial pressure, cardiac output, and systemic and pulmonary vascular resistances. Left atrial infusion of prostaglandin E1 produced dose-dependent reductions in mean arterial pressure and systemic vascular resistance but no change in the slope of the relationship of left ventricular stroke work to end-diastolic length, a load-independent index of ventricular performance. In contrast to findings obtained with load-dependent parameters, these results suggest that prostaglandin E1 has no positive inotropic effect in vivo.
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, NC 27710.
authors.forename: L A
authors.initials: LA
authors.lastname: Brunsting
authors.forename: D R
authors.initials: DR
authors.lastname: Salter
authors.forename: C E
authors.initials: CE
authors.lastname: Murphy
authors.forename: A S
authors.initials: AS
authors.lastname: Abd-Elfattah
authors.forename: J P
authors.initials: JP
authors.lastname: Goldstein
authors.forename: A S
authors.initials: AS
authors.lastname: Wechsler
mesh_terms: D000818:Animals; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects*; D011458:Prostaglandins E / Q000494:pharmacology*
chemical_list: D011458:Prostaglandins E