Sch 36605, a novel anti-inflammatory compound. Taxonomy, fermentation, isolation and biological properties.
A novel anti-inflammatory compound, Sch 36605, belonging to the blasticidin family of nucleoside compounds was isolated from the fermentation filtrate of a Streptomyces sp. Sch 36605, as well as blasticidin S, demonstrated anti-inflammatory activity in the reverse passive Arthus reaction and the adjuvant arthritic rat at doses ranging between 1-10 mg/kg and 0.3-6.0 mg/kg, respectively. A minor component, Sch 366606, co-produced in the in the fermentation was isolated and identified as a known compound in the blasticidin family of compounds.
Gullo
V
V
Pharmaceutical Research Division, Schering Plough Corporation, Bloomfield, New Jersey 07003.
Conover
M
M
Cooper
R
R
Federbush
C
C
Horan
A C
AC
Kung
T
T
Marquez
J
J
Patel
M
M
Watnick
A
A
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006146:Guanidines / Q000494:pharmacology; D051379:Mice; D009705:Nucleosides / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D006146:Guanidines; D009705:Nucleosides; C055111:Sch 36605; C004500:blasticidin S