Establishment and characteristics of five analbuminemic inbred strains of rats.
Five analbuminemic inbred strains of rats (AD/1, AD/2, AD/3, AD/4, AD/5) were established from Nagase analbuminemic rats (NAR). They showed no genetic differences in coat color, biochemical marker gene loci and skin grafting test. Their serum levels of total cholesterol, phospholipids, triglycerides, and beta-lipoproteins were compared with normal inbred strains (L) derived from Sprague-Dawley rats. Their plasma apoproteins were also examined. All inbred strains of analbuminemic rats showed hyperlipidemia progressing with age although there were slight variations in their lipid and apoprotein levels. These analbuminemic inbred strains of rats may be multigenic models of lipid metabolism abnormality.
Shumiya
S
S
Department of Laboratory Animals, Tokyo Metropolitan Institute of Gerontology, Japan.
Ando
S
S
Kon
K
K
Nagase
S
S
D000818:Animals; D001053:Apolipoproteins / Q000378:metabolism; D001947:Breeding; D005260:Female; D005819:Genetic Markers; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D011922:Rats, Mutant Strains / Q000097:blood*; D012709:Serum Albumin / Q000172:deficiency*; D016038:Skin Transplantation
D001053:Apolipoproteins; D005819:Genetic Markers; D008055:Lipids; D012709:Serum Albumin