title: Effect of pH on the production of irritation in a chamber irritation test.
abstract: This study was designed to investigate the relationship between alteration of skin surface pH and the development of skin irritation. Application of a phosphate/borate/acetate buffer adjusted to pH 4.0-10.5 in a standard chamber irritation test did not result in significant clinical irritation. This was true in spite of maintaining a markedly altered skin surface pH over an extended period of time. There was also no correlation between irritation and the pH of applied surfactant solutions. These results demonstrate that a prolonged disturbance of the "acid mantle" is not sufficient to produce clinical irritation.
authors.affiliation: Department of New Science and Technology, Dial Technical Center, Scottsdale, AZ 85254.
authors.forename: R I
authors.initials: RI
authors.lastname: Murahata
authors.forename: R
authors.initials: R
authors.lastname: Toton-Quinn
authors.forename: M B
authors.initials: MB
authors.lastname: Finkey
mesh_terms: D003902:Detergents / Q000009:adverse effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007509:Irritants; D012867:Skin / Q000187:drug effects*; D012915:Soaps / Q000009:adverse effects*; D013501:Surface-Active Agents / Q000009:adverse effects*
chemical_list: D003902:Detergents; D007509:Irritants; D012915:Soaps; D013501:Surface-Active Agents