title: Implantation of Bacteroides gingivalis in nonhuman primates initiates progression of periodontitis.
abstract: Although periodontitis is a bacterial disease, its multidimensional nature and its bacterial complexity have made it difficult to definitively prove that specific microorganisms initiate the disease process. The successful implantation of a rifampin-resistant strain of the putative periodontal pathogen Bacteroides gingivalis into the periodontal microbiota of monkeys (Macaca fascicularis) resulted in an increase in the systemic levels of antibody to the microorganism and rapid and significant bone loss.
authors.affiliation: Department of Periodontics, University of Texas Health Science Center at San Antonio 78284.
authors.forename: S C
authors.initials: SC
authors.lastname: Holt
authors.forename: J
authors.initials: J
authors.lastname: Ebersole
authors.forename: J
authors.initials: J
authors.lastname: Felton
authors.forename: M
authors.initials: M
authors.lastname: Brunsvold
authors.forename: K S
authors.initials: KS
authors.lastname: Kornman
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D001439:Bacteroides / Q000276:immunology / Q000472:pathogenicity*; D003773:Dental Plaque / Q000382:microbiology; D005260:Female; D005881:Gingiva / Q000382:microbiology; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008252:Macaca fascicularis; D010518:Periodontitis / Q000382:microbiology* / Q000473:pathology
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M