Effects of ornithine or arginine administration on serum amino acid levels.
In healthy humans after overnight fasting, an oral administration of ornithine induced a new steady state: an accumulation of serum alanine and proline, a decrease in serum valine concentration, transient reductions in serum urea and urinary urea contents, and then an increased urea excretion. On the other hand, an oral administration of arginine resulted in an anabolic state: decreases in serum leucine and isoleucine concentrations, reductions in serum glucose and free fatty acid contents and a rapid increase in serum insulin level. It was assumed that the effect of ornithine administration may be exerted through an activation of hepatic System A transport and that of arginine is an insulin-mediated action.
Iwasaki
K
K
Department of Biochemistry, School of Medicine, Fujita-Gakuen Health University, Aichi, Japan.
Mano
K
K
Ishihara
M
M
Yugari
Y
Y
Matsuzawa
T
T
D000328:Adult; D000596:Amino Acids / Q000097:blood*; D001120:Arginine / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000502:physiology; D007532:Isoleucine / Q000097:blood; D007930:Leucine / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009952:Ornithine / Q000494:pharmacology*; D014508:Urea / Q000097:blood; D014633:Valine / Q000097:blood
D000596:Amino Acids; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007532:Isoleucine; D014508:Urea; D001120:Arginine; D009952:Ornithine; D007930:Leucine; D014633:Valine