Twin vessels in von Hippel-Lindau disease.
We examined ten patients from three families with von Hippel-Lindau disease and 26 of their at-risk relatives for the presence of twin vessels, defined as a paired retinal arteriole and venule that are separated by less than the diameter of one venule and extend for a distance of more than one disk diameter. They were compared with 36 age- and sex-matched controls. Of the 36 subjects in the study group, 23 had twin vessels compared with two controls (P less than 10(-6). Of the ten patients, nine (14 eyes) had twin vessels; no twin vessels were found in their controls (P = 5.9 x 10(-5)). Fourteen at-risk relatives and two of their controls had twin vessels (P = 9.4 x 10(-4)).
de Jong
P T
PT
Department of Ophthalmology, Erasmus University, Rotterdam, The Netherlands.
Verkaart
R J
RJ
van de Vooren
M J
MJ
Majoor-Krakauer
D F
DF
Wiegel
A R
AR
D000328:Adult; D000798:Angiomatosis / Q000235:genetics* / Q000473:pathology; D005134:Eye Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D010375:Pedigree; D012160:Retina / Q000473:pathology*; D012171:Retinal Vessels / Q000002:abnormalities / Q000473:pathology*; D012307:Risk Factors