title: In-111-labeled liposomes: dosimetry and tumor depiction.
abstract: Neutral phospholipid vesicles (liposomes) were loaded with 0.5 mCi (18.5 MBq) indium-111 and administered to 24 patients with various types of cancer. The median diameter of the liposomes was 77 nm, and lipid dose was 0.78-6.25 mg/kg. Scans obtained 24 and 48 hours after injection of In-111 liposomes showed gradual blood clearance with homogeneous uptake in the normal liver and spleen. Dosimetric estimates for these organs were 2.3 +/- 1.1 and 2.3 +/- 1.4 rad (.02 +/- .01 Gy), respectively, with a whole-body estimate of 0.28 rad (.003 Gy). Radiation dose did not correlate with lipid dose. Total renal excretion of In-111 was less than 2% of the injected dose in all but two patients. Transient eosinophilia occurred in two patients. Tumor was seen in the scans of 22 of 24 patients (unbinded readings). In-111-labeled liposomes may enable the demonstration of suspected or unsuspected sites of tumor.
authors.affiliation: Department of Radiology, San Gabriel Medical Center, CA 91776.
authors.forename: A F
authors.initials: AF
authors.lastname: Turner
authors.forename: C A
authors.initials: CA
authors.lastname: Presant
authors.forename: R T
authors.initials: RT
authors.lastname: Proffitt
authors.forename: L E
authors.initials: LE
authors.lastname: Williams
authors.forename: D W
authors.initials: DW
authors.lastname: Winsor
authors.forename: J L
authors.initials: JL
authors.lastname: Werner
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism; D005770:Gastrointestinal Neoplasms / Q000378:metabolism; D006801:Humans; D007205:Indium Radioisotopes / Q000493:pharmacokinetics; D008081:Liposomes / Q000493:pharmacokinetics*; D008175:Lung Neoplasms / Q000378:metabolism; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism; D011879:Radiotherapy Dosage; D014018:Tissue Distribution
chemical_list: D007205:Indium Radioisotopes; D008081:Liposomes