title: In vitro mefloquine resistance of Plasmodium falciparum isolated from the Burmese border region of Thailand.
abstract: The in vitro susceptibility of twenty isolates of Plasmodium falciparum from Tha Song Yang, Tak province, Thailand were determined. The isolates were resistant to chloroquine (IC50 = 220 nM; MIC = 762 nM), quinine (IC50 = 252 nM; MIC = 1010 nM), and pyrimethamine (IC50 = 16400 nM; MIC = 43100 nM) but generally sensitive to mefloquine (IC50 = 6.90 nM; MIC = 20.9 nM) and halofantrine (IC50 = 8.73 nM; MIC = 2.71 nM). Two isolates were identified which appeared resistant to mefloquine (IC50 = 23.1 nM; MIC = 56.6 nM). These isolates may represent an extension of a population of parasites from eastern Thailand.
authors.affiliation: U.S. Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
authors.forename: G E
authors.initials: GE
authors.lastname: Childs
authors.forename: L
authors.initials: L
authors.lastname: Pang
authors.forename: T
authors.initials: T
authors.lastname: Wimonwattrawatee
authors.forename: N
authors.initials: N
authors.lastname: Pooyindee
authors.forename: A
authors.initials: A
authors.lastname: Nanakorn
authors.forename: S
authors.initials: S
authors.lastname: Limchitee
authors.forename: H K
authors.initials: HK
authors.lastname: Webster
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D004351:Drug Resistance; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology*; D015767:Mefloquine; D010963:Plasmodium falciparum / Q000187:drug effects*; D011804:Quinolines / Q000494:pharmacology* / Q000627:therapeutic use; D013785:Thailand
chemical_list: D000962:Antimalarials; D011804:Quinolines; D015767:Mefloquine