Reduction of tumor growth following treatment with a glutamine antimetabolite.
Assessment of arterial-venous differences across transplanted methylcholanthrene-induced sarcomas in rats revealed significant decreases in plasma concentrations of glutamine, serine and glucose. Treatment with the glutamine antimetabolite, acivicin, significantly reduced tumor weights by 65% at the conclusion of the experiment 34 days after tumor induction. These results suggest that glutamine is an essential metabolic substrate for tumor growth and that blockade of glutamine utilization can inhibit the growth of these transplantable sarcomas.
Chance
W T
WT
Department of Surgery, University of Cincinnati Medical Center, OH 45267.
Cao
L
L
Kim
M W
MW
Nelson
J L
JL
Fischer
J E
JE
D000596:Amino Acids / Q000097:blood; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D000963:Antimetabolites / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002149:Energy Intake; D005973:Glutamine / Q000097:blood*; D007555:Isoxazoles / Q000494:pharmacology*; D008297:Male; D008748:Methylcholanthrene; D010080:Oxazoles / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000473:pathology*
D000596:Amino Acids; D000903:Antibiotics, Antineoplastic; D000963:Antimetabolites; D007555:Isoxazoles; D010080:Oxazoles; D005973:Glutamine; D008748:Methylcholanthrene; C006303:acivicin