In-111-labeled liposomes: dosimetry and tumor depiction.
Neutral phospholipid vesicles (liposomes) were loaded with 0.5 mCi (18.5 MBq) indium-111 and administered to 24 patients with various types of cancer. The median diameter of the liposomes was 77 nm, and lipid dose was 0.78-6.25 mg/kg. Scans obtained 24 and 48 hours after injection of In-111 liposomes showed gradual blood clearance with homogeneous uptake in the normal liver and spleen. Dosimetric estimates for these organs were 2.3 +/- 1.1 and 2.3 +/- 1.4 rad (.02 +/- .01 Gy), respectively, with a whole-body estimate of 0.28 rad (.003 Gy). Radiation dose did not correlate with lipid dose. Total renal excretion of In-111 was less than 2% of the injected dose in all but two patients. Transient eosinophilia occurred in two patients. Tumor was seen in the scans of 22 of 24 patients (unbinded readings). In-111-labeled liposomes may enable the demonstration of suspected or unsuspected sites of tumor.
Turner
A F
AF
Department of Radiology, San Gabriel Medical Center, CA 91776.
Presant
C A
CA
Proffitt
R T
RT
Williams
L E
LE
Winsor
D W
DW
Werner
J L
JL
D001943:Breast Neoplasms / Q000378:metabolism; D005770:Gastrointestinal Neoplasms / Q000378:metabolism; D006801:Humans; D007205:Indium Radioisotopes / Q000493:pharmacokinetics; D008081:Liposomes / Q000493:pharmacokinetics*; D008175:Lung Neoplasms / Q000378:metabolism; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism; D011879:Radiotherapy Dosage; D014018:Tissue Distribution
D007205:Indium Radioisotopes; D008081:Liposomes