[Determination of fibrinogen-fibrin degradation factors in neoplasms].
Disseminated intravascular coagulation (DIC) and Primary Fibrinolysis (PF) are frequently reported in the literature as occurring in a wide variety of tumours whether subjected to chemotherapy or not and triggering a thrombohemorrhagic mechanism that is often fatal. It was therefore decided to assess the extent of the Fibrinogen-Fibrin Degradation Products (FDP) in a group of cancer patients in order to identify the primary, asymptomatic clinical expressions of these syndromes with a view to ascertaining the possibility of preventing more severe forms. The data confirm the presence of circulating FDP in a small percentage of the patients (26.9%) especially those with solid tumours metastasising to the liver. The involvement of that organ is therefore considered decisive for the onset of DIC and PF.
Petrella
V
V
U.S.L. n. 54 - Borgomanero (Novara) Divisione di Medicina Generale.
Massara
G
G
Parachini
F
F
Silvera
F
F
Cantone
R
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*; D012016:Reference Values
D005338:Fibrin Fibrinogen Degradation Products
Determinazione dei fattori di degradazione fibrinogeno-fibrina (FDP) in corso di neoplasie.