[Significance of polyamines for the early diagnosis of spontaneous hemoblastoses in AKR mice].
Polyamines levels were studied in various tissue specimens obtained from high-leukemia AKR mice aged 12 months and less. Organ tissues of leukemic animals revealed increased levels of polyamines and changes in their profile. In symptomatic mice, this was matched by relevant morphologic changes. It is inferred that putrescine is a marker of latent leukemia development.
Voronchikhina
L D
LD
Vorozhtsova
S I
SI
Minakov
V N
VN
Zinov'ev
Iu V
IuV
Shkanakina
T P
TP
D000818:Animals; D014408:Biomarkers, Tumor; D001923:Brain Chemistry; D005260:Female; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008223:Lymphoma / Q000378:metabolism*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D011073:Polyamines / Q000096:biosynthesis*; D011700:Putrescine / Q000096:biosynthesis; D013095:Spermidine / Q000096:biosynthesis; D013096:Spermine / Q000096:biosynthesis; D013154:Spleen / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism
D014408:Biomarkers, Tumor; D011073:Polyamines; D013096:Spermine; D013095:Spermidine; D011700:Putrescine
Znachenie poliaminov dlia ranneĭ diagnostiki spontannykh gemoblastozov mysheĭ AKR.