An investigation into the role of ascorbic acid in renal calculogenesis in albino rats.
Neither stone nor calcium oxalate crystal deposition was observed in the kidneys of rats after oral ingestion of 60 mg. L-ascorbic acid daily for three months, although urinary excretion of stone inhibitors (magnesium and citrate) was decreased and oxalate increased. The highly acidic pH of urine and reduced calcium excretion might have prevented their deposition.
Singh
P P
PP
Department of Biochemistry, R.N.T. Medical College, Udaipur, India.
Sharma
D C
DC
Rathore
V
V
Surana
S S
SS
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism / Q000633:toxicity*; D002129:Calcium Oxalate / Q000378:metabolism; D007669:Kidney Calculi / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D051381:Rats
D002129:Calcium Oxalate; D001205:Ascorbic Acid