Prevention of recurrent ulcer bleeding, a multicentre study of the effect of ranitidine and trimipramine over one year.
Short term studies of the prevention of bleedings from peptic ulcers and erosions have been reported by a number of authors following treatment with antacids (1), H2-receptor blockers, cimetidine (2-15), a combination of cimetidine and tranexamic acid (16), cimetidine and somatostatin (17), cimetidine and sucralfate or secretion (18, 19, 20), cimetidine compared to antacid (21), and cimetidine compared to antacid and pirenzepine (22). The H2-blocker rantitidine has been compared to placebo (24, 25, 26). An uncontrolled study has been performed using proglumide (27), a controlled study with vasopressin (28) and with secretin versus somatostatin (28). In the studies with H2-receptor antagonists conflicting results have been obtained. No report has been published concerning the effect over more than a few days or weeks.
Stave
R
R
Department of Medicine, Ulleval University Hospital, Oslo, Norway.
Myren
J
J
Osnes
M
M
D003984:Dibenzazepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D015337:Multicenter Studies as Topic; D009664:Norway; D010438:Peptic Ulcer Hemorrhage / Q000517:prevention & control*; D011897:Random Allocation; D011899:Ranitidine / Q000627:therapeutic use*; D012008:Recurrence; D013997:Time Factors; D014299:Trimipramine / Q000627:therapeutic use*
D003984:Dibenzazepines; D014299:Trimipramine; D011899:Ranitidine