title: Decreases of cortical and thalamic glucose metabolism produced by parietal cortex stimulation in the rat.
abstract: Parietal cortex stimulation elicited focal decreases as well as increases of brain glucose metabolism in ipsilateral cortex, ipsilateral thalamus, and contralateral cortex of rats in a pattern resembling 'surround inhibition'. It is proposed that parietal stimulation activated inhibitory circuits which decreased cortical and thalamic glucose metabolism. This decrease of cerebral glucose metabolism is important for interpreting brain glucose metabolic studies particularly when metabolic changes do not correlate with changes of neuronal activity.
authors.affiliation: Department of Neurology, University of California, San Francisco.
authors.forename: J W
authors.initials: JW
authors.lastname: Sharp
authors.forename: M F
authors.initials: MF
authors.lastname: Gonzalez
authors.forename: M T
authors.initials: MT
authors.lastname: Morton
authors.forename: R P
authors.initials: RP
authors.lastname: Simon
authors.forename: F R
authors.initials: FR
authors.lastname: Sharp
mesh_terms: D000818:Animals; D001345:Autoradiography; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D004558:Electric Stimulation; D007839:Functional Laterality / Q000502:physiology; D006614:Hindlimb / Q000294:innervation; D009434:Neural Pathways / Q000378:metabolism; D010296:Parietal Lobe / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013003:Somatosensory Cortex / Q000378:metabolism* / Q000502:physiology; D013788:Thalamus / Q000378:metabolism*
chemical_list: D003837:Deoxy Sugars; D003847:Deoxyglucose