Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements.
Oncogenes have been implicated in tumorigenesis based on their localization to chromosomal sites associated with tumor-specific structural rearrangements. We have mapped the human ros1 (formerly mcf3) and mas1 oncogenes to the distal half of chromosome 6q, within a region frequently rearranged in malignant cells. Chromosomal mapping of these two new human transforming genes may help elucidate the involvement of the long arm of chromosome 6 in diverse tumor types.
Rabin
M
M
University of Miami School of Medicine, Department of Pediatrics, Florida 33101.
Birnbaum
D
D
Young
D
D
Birchmeier
C
C
Wigler
M
M
Ruddle
F H
FH
D002460:Cell Line; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D011905:Genes, ras; D006801:Humans; D007938:Leukemia / Q000235:genetics; D009369:Neoplasms / Q000235:genetics; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D000090063:Proto-Oncogene Mas