title: Detection of overdosage of sedation in a patient with renal failure by the absence of lower oesophageal motility.
abstract: We report an accidental overdosage of morphine and midazolam in a patient with renal failure receiving haemofiltration detected by the absence of oesophageal motility. This situation demonstrates the difficulties of assessing the level of sedation as well as the dosage requirements in this type of patient.
authors.affiliation: Surgical Intensive Care Unit, University Hospital of Geneva, Switzerland.
authors.forename: M E
authors.initials: ME
authors.lastname: Sinclair
authors.forename: P M
authors.initials: PM
authors.lastname: Suter
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications*; D000328:Adult; D004947:Esophagus / Q000502:physiology*; D006440:Hemofiltration; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000506:poisoning*; D008297:Male; D008874:Midazolam / Q000506:poisoning; D009020:Morphine / Q000506:poisoning; D009119:Muscle Contraction; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000506:poisoning*; D010197:Pancuronium / Q000506:poisoning
chemical_list: D006993:Hypnotics and Sedatives; D009466:Neuromuscular Blocking Agents; D009020:Morphine; D010197:Pancuronium; D008874:Midazolam