Monthly variations in the pharmacokinetics of antipyrine in the rat: circannual rhythm or random variation?
We examined the pharmacokinetics of antipyrine in the rat over an 18 month period to determine whether or not the variations in pharmacokinetic parameters previously reported exhibited a circannual rhythm. While the clearance of antipyrine varied over the study period, no discernible rhythmic pattern was found. Comparing this data with previously published work also failed to demonstrate a rhythmic pattern of variability. Unlike previous investigations, we found only relatively small variations in antipyrine volume of distribution and half-life from month to month. These data indicate that the monthly variability in the pharmacokinetics of antipyrine in the rat are random and do not exhibit a circannual rhythm.
Svensson
C K
CK
Department of Pharmaceutical Sciences, College of Pharmacy & Allied Health Professions, Wayne State University, Detroit, Michigan 48202.
Chong
M T
MT
Edwards
D J
DJ
D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D010507:Periodicity; D051381:Rats; D011919:Rats, Inbred Strains
D000983:Antipyrine