title: Effects of felodipine and metoprolol on blood pressure, plasma renin, angiotensin II, aldosterone and catecholamines in hypertensive patients.
abstract: Oral administration of felodipine to 10 patients with mild essential hypertension acutely reduced the brachial artery pressure by 15/13mm Hg. The tachycardia which occurred was sustained for 90 minutes together with an elevated plasma noradrenaline concentration. Addition of intravascular metoprolol after 90 minutes decreased heart rate. The felodipine-induced increase of plasma renin activity (100%; p less than 0.001) was completely reversed by metoprolol. Plasma angiotensin II (PA II) rose by 15% (p less than 0.05) during felodipine, whereas plasma aldosterone concentration was not significantly affected.
authors.affiliation: Department of Pathophysiology, University of Leuven.
authors.forename: P
authors.initials: P
authors.lastname: Lijnen
authors.forename: R
authors.initials: R
authors.lastname: Fagard
authors.forename: J
authors.initials: J
authors.lastname: Staessen
authors.forename: E
authors.initials: E
authors.lastname: Moerman
authors.forename: A
authors.initials: A
authors.lastname: De Schaepdryver
authors.forename: A
authors.initials: A
authors.lastname: Amery
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D000959:Antihypertensive Agents / Q000097:blood / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000097:blood; D004562:Electrocardiography; D015736:Felodipine; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008790:Metoprolol / Q000097:blood / Q000627:therapeutic use*; D009568:Nitrendipine / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D012083:Renin / Q000097:blood; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D002395:Catecholamines; D000804:Angiotensin II; D000450:Aldosterone; D009568:Nitrendipine; D012083:Renin; D008790:Metoprolol; D015736:Felodipine