Prospective nerve conduction studies in cisplatin therapy.
We studied nerve conduction prospectively in 38 women receiving cisplatin for gynecological malignancies. Decreased sensory nerve action potential amplitudes and prolonged sensory latencies were the only significant changes identified. This prospective electrophysiological study validates the clinical observation of frequent sensory symptoms and occasional sensory neuropathies associated with cisplatin therapy.
Riggs
J E
JE
Department of Neurology, West Virginia University School of Medicine, Morgantown.
Ashraf
M
M
Snyder
R D
RD
Gutmann
L
L
D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D000368:Aged; D002945:Cisplatin / Q000009:adverse effects*; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects*; D010525:Peripheral Nerves / Q000503:physiopathology; D011446:Prospective Studies; D011930:Reaction Time
D002945:Cisplatin