The development of specific IgG4 after immunotherapy with standardized extracts.
A significant reduction in symptoms scores was observed in those patients who elected to continue their immunotherapy after achieving maintenance. All of those patients developed allergen specific IgG4 within a year of post-maintenance injections. These findings suggest that a reduction of allergic symptoms is accompanied by a rise in specific IgG4 antibody against the offending allergen(s). These specific IgG4 antibodies can be induced by appropriate immunotherapy. Lastly, allergen specific IgG4 antibodies were rapidly and accurately determined using the 3M IgG4 FAST test.
Harris
N S
NS
3M Diagnostic Systems, Santa Clara, CA 95051.
Rock
H S
HS
Leese
P T
PT
D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000008:administration & dosage* / Q000276:immunology; D002986:Clinical Trials as Topic; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000628:therapy*; D007118:Immunoassay; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000145:classification; D008297:Male; D008875:Middle Aged
D000485:Allergens; D007074:Immunoglobulin G; D007073:Immunoglobulin E