title: Oral manifestations of systemic chemotherapy and their management.
abstract: Many antineoplastic drugs in use now have cytotoxic side effects that also manifest in the oral cavity or influence dental management. Chemotherapeutic agents that have a high potential for precipitating oral mucosal damage and bone marrow depression are methotrexate, cyclophosphamide, daunorubicin, doxorubicin hydrochloride, 5-fluorouracil, bleomycin, nitrogen mustard, cytosine-arabinoside, 6-mercaptopurine, busulfan, and L-phenylalanine mustard. Mucositis may lead to neglected oral hygiene, which in turn may cause a chain reaction of local infections, bleeding, and septicemia in myelosuppressed patients. Preventive oral care before chemotherapy and active oral care during therapy are necessary for compromised patients. A protocol for oral care is described.
authors.affiliation: Department of Dentistry and Maxillofacial Prosthetics, Roswell Park Memorial Institute, Buffalo, New York 14263.
authors.forename: W
authors.initials: W
authors.lastname: Carl
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D001855:Bone Marrow Diseases / Q000139:chemically induced / Q000276:immunology; D016026:Bone Marrow Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D009059:Mouth Diseases / Q000139:chemically induced* / Q000517:prevention & control; D009910:Oral Hygiene / Q000379:methods*; D014076:Tooth Diseases / Q000139:chemically induced* / Q000517:prevention & control
chemical_list: D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents