Changes in plasma gangliosides in relation to tumor growth and their tumor-enhancing effect.
Gangliosides in the plasma of Ehrlich ascites tumor-bearing mice showed changes, both quantitative and qualitative, with progress of tumor. Quantitative changes assessed by chemical estimation indicated a gradual increase of gangliosides up to day 6 of tumor growth followed by a decline leading to a level below the normal by day 12. Qualitative changes studied by thin-layer chromatography indicated appearance of new gangliosides in the plasma of tumor-bearing mice, which were absent from normal plasma. One of these gangliosides appears to be of tumor-cell origin. Gangliosides obtained from tumor-bearing mouse plasma enhanced tumor growth when adoptively transferred with tumor cells into normal mice.
Saha
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Department of Tumor Immunobiology, Chittaranjan National Cancer Research Centre, Calcutta, India.
Chattopadhyay
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D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000097:blood / Q000276:immunology*; D002855:Chromatography, Thin Layer; D005732:Gangliosides / Q000097:blood* / Q000276:immunology; D007116:Immunization, Passive; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation
D005732:Gangliosides