title: Ejaculatory failure and urinary dysfunction secondary to labetalol.
abstract: We describe 3 men with moderate to severe essential hypertension in whom ejaculatory failure developed after therapy with labetalol, an antihypertensive drug with alpha-1 and beta-adrenergic blocking properties. No decrease in libido or erectile dysfunction was reported by any of the patients. Previous and subsequent antihypertensive therapy with either alpha or beta-adrenergic blocking agents failed to cause similar symptoms. These findings reveal a unique spectrum of genitourinary dysfunction associated with the multireceptor blocking properties of labetalol.
authors.affiliation: Hypertension Unit, University of Connecticut School of Medicine, Farmington.
authors.forename: J
authors.initials: J
authors.lastname: O'Meara
authors.forename: W B
authors.initials: WB
authors.lastname: White
mesh_terms: D000328:Adult; D004542:Ejaculation / Q000187:drug effects*; D006801:Humans; D007741:Labetalol / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D014555:Urination Disorders / Q000139:chemically induced*
chemical_list: D007741:Labetalol