Supposed coeliac disease during childhood and its presentation 14-38 years later.
Thirty-five subjects treated with a gluten-free diet for a chronic gastrointestinal disorder (no biopsy performed) in early childhood were re-examined 14-38 (median, 28) years later. Twenty-one accepted jejunal biopsy at re-examination. None of those studied were on a gluten-free diet at the time of the study. Ten of 21 biopsy specimens were abnormal--6 with flat mucosa and very low disaccharidase levels, indicating coeliac disease, and 4 with low disaccharidase activity but morphologically normal mucosa. Three of the six subjects with flat mucosa showed a slight fat and lactose malabsorption, but their clinical condition did not suggest serious intestinal disease. Ingestion of gluten throughout most of childhood did not appear to affect growth, as evaluated by final height. Jejunal biopsy is recommended in all patients with gastrointestinal symptoms that are not otherwise explainable if their medical history shows a period of gluten-free diet for a chronic gastrointestinal disorder in childhood.
Paerregaard
A
A
Dept. of Pediatrics, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark.
Vilien
M
M
Krasilnikoff
P A
PA
Gudmand-Høyer
E
E
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007421:Intestine, Small / Q000201:enzymology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013997:Time Factors