Corticosteroids stimulate an increase in phospholipase A2 inhibitor in human serum.
A corticosteroid induced increase in a circulating inhibitor of serum phospholipase A2 activity is described. Inhibitor activity was found to be normally present in serum in agreement with the findings of other workers, and this activity was significantly increased by either acute or chronic administration of corticosteroids. The possible relation of this inhibitor to the known inhibitory effects of lipocortin and sphingomyelin on phospholipase A2 activity is briefly discussed.
Sorenson
D K
DK
Department of Medicine, University of Utah School of Medicine, Salt Lake City 84132.
Kelly
T M
TM
Murray
D K
DK
Nelson
D H
DH
D004791:Enzyme Inhibitors / Q000302:isolation & purification; D006801:Humans; D007700:Kinetics; D008297:Male; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D011241:Prednisone / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000097:blood*; D012016:Reference Values
D004791:Enzyme Inhibitors; D011480:Protease Inhibitors; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; D011241:Prednisone