title: Mutagenic action of phaseolinone, a mycotoxin isolated from Macrophomina phaseolina.
abstract: Phaseolinone was mutagenic to excision-repair-deficient strains of Escherichia coli WP2 and also to Salmonella typhimurium TA 100. The repair test was indicative of covalent binding of the toxin to DNA. The side-chain epoxide and the hydroxy groups of the molecule were found to be essential for mutagenic activity.
authors.affiliation: Indian Institute of Chemical Biology, Jadavpur, Calcutta.
authors.forename: G
authors.initials: G
authors.lastname: Bhattacharya
authors.forename: T K
authors.initials: TK
authors.lastname: Dhar
authors.forename: F K
authors.initials: FK
authors.lastname: Bhattacharyya
authors.forename: K A
authors.initials: KA
authors.lastname: Siddiqui
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D004926:Escherichia coli / Q000187:drug effects; D003904:Mitosporic Fungi / Q000032:analysis*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000302:isolation & purification*; D009183:Mycotoxins / Q000302:isolation & purification / Q000494:pharmacology*; D009284:Naphthols / Q000302:isolation & purification / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D009153:Mutagens; D009183:Mycotoxins; D009284:Naphthols; C056401:phaseolinone