Midazolam for induction of anaesthesia in patients with limited cardiac reserves. A comparison with etomidate.
The new water-soluble benzodiazepine, midazolam (Dormicum; Roche), was compared with etomidate as part of a balanced technique for induction of anaesthesia in 16 patients undergoing cardiac valve replacement. Monitoring revealed a significantly greater fall in blood pressure in patients receiving midazolam (reaching dangerous levels in 2 patients), which suggests that this agent is not suitable for induction of anaesthesia in haemodynamically compromised patients.
MacGillivray
R G
RG
Department of Anaesthetics, University of Natal, Durban.
Rocke
D A
DA
Mahomedy
A E
AE
D000328:Adult; D000768:Anesthesia, General / Q000379:methods*; D001794:Blood Pressure / Q000187:drug effects*; D005045:Etomidate / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006351:Heart Valves / Q000637:transplantation; D006801:Humans; D008297:Male; D008874:Midazolam / Q000494:pharmacology*; D011897:Random Allocation; D013997:Time Factors
D008874:Midazolam; D005045:Etomidate