Human cornea: individual responses to hypoxic environments.
Using a micropolarographic system, the responses of seven human corneas to oxygen atmospheres ranging from 20.9% to 0% were measured. Under normal atmospheric conditions, ratios of oxygen demand were observed between corneas as great as 1.23:1. Following 0% oxygen conditions, however, these ratios rose to a maximum of 1.93:1, i.e., representing demand differences between particular corneas of nearly 2:1. Such differences may prove increasingly important in the gauging of patient suitability and safety in relation to hypoxic stress, e.g., the extended wear of contact lenses.
Benjamin
W J
WJ
Ohio State University, College of Optometry, Columbus 43210-1240.
Hill
R M
RM
D000328:Adult; D003315:Cornea / Q000378:metabolism / Q000502:physiology*; D005143:Eyelids / Q000502:physiology; D006801:Humans; D010100:Oxygen / Q000494:pharmacology*; D010101:Oxygen Consumption; D010313:Partial Pressure; D011048:Polarography
D010100:Oxygen