Evidence for a novel gene associated with low tumor metastatic potential.
We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identified, and (2) N-nitroso-N-methylurea-induced rat mammary carcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsic aggressiveness. The predicted carboxy-terminal protein sequence encoded by the pNM23 cDNA clone is novel compared with Genebank animal, bacterial, and viral sequences.
Steeg
P S
PS
Division of Cancer Biology and Diagnosis, National Cancer Institute, Bethesda, MD 20892.
Bevilacqua
G
G
Kopper
L
L
Thorgeirsson
U P
UP
Talmadge
J E
JE
Liotta
L A
LA
Sobel
M E
ME
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005796:Genes; D008325:Mammary Neoplasms, Experimental / Q000235:genetics* / Q000473:pathology; D008546:Melanoma, Experimental / Q000235:genetics* / Q000473:pathology; D051379:Mice; D008969:Molecular Sequence Data; D009362:Neoplasm Metastasis
D004273:DNA, Neoplasm