[Polyploidization of rat hepatocytes due to cell fusion caused by radiations of different LET].
The method of flow cytometry was used to study polyploidization of hepatocytes following X-, gamma-, and neutron-irradiation. Ionizing radiation was shown to induce cell polyploidization by two different ways: (1) cells and nuclei fusion, and (2) restriction of mitosis after DNA replication. RBE of 14 MeV neutrons with respect to fusion was about 5.10(3). With neutron irradiation, the sensitivity of cells by fusion was not lower than that by chromosome mutations.
Gil'iano
N Ia
NIa
Malinovskiĭ
O V
OV
Khair
M B
MB
Baldychev
A S
AS
Smolin
V A
VA
D000818:Animals; D002459:Cell Fusion / Q000528:radiation effects*; D004735:Energy Transfer; D005720:Gamma Rays; D008099:Liver / Q000166:cytology / Q000528:radiation effects*; D008297:Male; D009502:Neutrons; D011123:Polyploidy; D051381:Rats; D012062:Relative Biological Effectiveness
Poliploidizatsiia gepatotsitov krys, obuslovlennaia sliianiem kletok pri deĭstvii izlucheniĭ s raznoĭ LPE.