title: Rhythmic variations of different hemopoietic cell lines and maturation stages in aging mice.
abstract: Non-proliferative and proliferative myeloid, and lymphoid and erythroid bone marrow cells were studied in aging female C3H mice. A chronobiological approach was used and mice aged 16, 21 and 26 months were examined vs. 3 month-old mice every 3 h during the 24-h period in three different experiments. Significant circadian fluctuations were observed in most of the cell populations, even in the oldest mice. The rhythmicity patterns might be different at different times of the year, and in young mice seasonal fluctuations in the 24-h mean values were observed. The absolute numbers of the 24-h means seemed to be highest at 21 months of age in all cell lines and maturation stages. Sinus function fitting indicated a decline of the amplitudes in aging mice. Minor age-related phase-differences were indicated in some populations. However, the fitting of original data to single sinus functions was variable and often obscured important features in the cell number variations. The present investigation illustrates the importance of performing time-sequence studies in hematology.
authors.affiliation: Gade Institute, Department of Pathology, University of Bergen, Haukeland Hospital, Norway.
authors.forename: O
authors.initials: O
authors.lastname: Sletvold
authors.forename: O D
authors.initials: OD
authors.lastname: Laerum
authors.forename: T
authors.initials: T
authors.lastname: Riise
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001853:Bone Marrow / Q000502:physiology*; D002455:Cell Division; D002940:Circadian Rhythm; D005260:Female; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D008214:Lymphocytes / Q000502:physiology; D051379:Mice; D008809:Mice, Inbred C3H