title: Absence of mutagenicity of Potomorphe umbellata and Potomorphe peltata in the Salmonella/mammalian-microsome mutagenicity assay.
abstract: The development of short term tests for measuring the mutagenic activity of genotoxic chemicals has been helpful in increasing security. Natural products from the flora are largely used in popular medicine. Using the Salmonella/mammalian-microsome assay, we investigated the genetic toxicity of two plant species popularly used in malaria treatment, Pothomorphe umbellata and Pothomorphe peltata. The data show the absence of genetic toxicity for both plant species.
authors.affiliation: Departamento de Ciências Fisiológicas, Universidade do Estado do Rio de Janeiro, Brasil.
authors.forename: I
authors.initials: I
authors.lastname: Felzenszwalb
authors.forename: J O
authors.initials: JO
authors.lastname: Valsa
authors.forename: A C
authors.initials: AC
authors.lastname: Araujo
authors.forename: R
authors.initials: R
authors.lastname: Alcantara-Gomes
mesh_terms: D000818:Animals; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D009152:Mutagenicity Tests / Q000379:methods; D010936:Plant Extracts / Q000627:therapeutic use / Q000633:toxicity*; D010946:Plants, Medicinal; D012486:Salmonella typhimurium / Q000235:genetics*
chemical_list: D010936:Plant Extracts