title: Effect of synthetic human cholecystokinin-33 on exocrine pancreas.
abstract: Synthetic human cholecystokinin-33 was first evaluated with respect to the biological activity on the pancreatic protein secretion. Human cholecystokinin-33 increased pancreatic protein secretion in a dose-related manner. The relative molar potency of this substance compared to that of synthetic cholecystokinin-8 (taken as 1.0) was 0.92. This study supports the concept that longer molecular forms of cholecystokinin are quantitatively important mediators of biological action of cholecystokinin on the pancreas.
authors.affiliation: Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Doi
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Kogire
authors.forename: S
authors.initials: S
authors.lastname: Sumi
authors.forename: M
authors.initials: M
authors.lastname: Yun
authors.forename: S
authors.initials: S
authors.lastname: Futaki
authors.forename: N
authors.initials: N
authors.lastname: Fujii
authors.forename: H
authors.initials: H
authors.lastname: Yajima
authors.forename: T
authors.initials: T
authors.lastname: Tobe
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D004285:Dogs; D006801:Humans; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D012844:Sincalide / Q000494:pharmacology
chemical_list: D011506:Proteins; D002766:Cholecystokinin; D012844:Sincalide