Alteration in the disposition and metabolism of S(-)-propranolol in rats with active respiratory viral infection.
Viral illness elicited marked changes in the disposition and metabolism of S(-)-propranolol in rats during the course of a recent viral outbreak in our rodent colony. A slower rate of gastrointestinal absorption and a much higher clearance of orally-administered S(-)-propranolol were observed. The apparent increase in metabolic clearance is partly attributed to a decrease in the serum protein binding of S(-)-propranolol. A direct stimulation of microsomal oxidative metabolism was also suggested by an increase in urinary recovery of the monohydroxyl metabolites of S(-)-propranolol. In addition, a greater portion of the phenolic metabolites were present in urine as the glucuronic acid conjugates, which may be explained by a concomitant stimulation in conjugative reaction. These observations are unusual in that existing reports indicate that viral illness in man and animals generally leads to an inhibition of oxidative drug metabolism.
Kwong
E C
EC
Department of Pharmaceutics, University of Washington BG-20, Seattle 98195.
Laganière
S
S
Savitch
J L
JL
Nelson
W L
WL
Shen
D D
DD
D000284:Administration, Oral; D000818:Animals; D007408:Intestinal Absorption; D008297:Male; D010636:Phenols / Q000652:urine; D011433:Propranolol / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D012141:Respiratory Tract Infections / Q000378:metabolism*; D014777:Virus Diseases / Q000378:metabolism*
D010636:Phenols; D011433:Propranolol