Immunologic reconstitution of foals with combined immunodeficiency.
Thirty-eight foals with combined immunodeficiency (CID) received transplanted fetal liver cells, fetal liver and thymus cells, histocompatible bone marrow cells, or equine lymphocyte antigen (ELA) haploidentical bone marrow cells in an attempt to reconstitute their deficient immune systems. Engraftment was infrequent, partial, and unpredictable when fetal cells were employed. Three of five CID foals receiving ELA haploidentical bone marrow cells demonstrated partial reconstitution, but engraftment was only temporary. Administration of histocompatible bone marrow cells resulted in rapid, full and sustained engraftment.
Perryman
L E
LE
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
Bue
C M
CM
Magnuson
N S
NS
Mottironi
V D
VD
Ochs
H S
HS
Wyatt
C R
CR
D000818:Animals; D016026:Bone Marrow Transplantation; D006648:Histocompatibility; D006734:Horse Diseases / Q000276:immunology / Q000628:therapy*; D006736:Horses / Q000196:embryology / Q000276:immunology*; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000628:therapy / Q000662:veterinary*; D008099:Liver / Q000196:embryology; D016031:Liver Transplantation; D008221:Lymphoid Tissue / Q000637:transplantation*; D013950:Thymus Gland / Q000196:embryology / Q000637:transplantation