The lateral distribution of cholesterol in the plane of lipid multibilayers.
We consider three models of cholesterol distribution in the plane of a bilayer of DMPC. We analyse recent 2H-NMR data obtained from deuterated fluorescent probes and show that, on the characteristic time-scale of 2H-NMR, it is in accord with a random distribution of cholesterol in a fluid-like DMPC bilayer in a single phase at least for T greater than or approximately equal to 35 degrees C and for 0 less than or equal to c less than or equal to 0.42.
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Centre for Mathematical Simulation, St. Francis Xavier University, Antigonish, Nova Scotia, Canada.
MacDonald
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D002784:Cholesterol / Q000378:metabolism*; D004134:Dimyristoylphosphatidylcholine / Q000378:metabolism*; D004161:Diphenylhexatriene; D008051:Lipid Bilayers / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008954:Models, Biological; D011336:Probability; D013696:Temperature
D008051:Lipid Bilayers; D008081:Liposomes; D004161:Diphenylhexatriene; D002784:Cholesterol; D004134:Dimyristoylphosphatidylcholine