Quinidine-induced lupus erythematosus-like syndrome: three case reports and a review of the literature.
Three patients with an LE-like syndrome secondary to quinidine are described. Twenty-two similar cases are reviewed. The clinical picture is characterized mainly by polyarthritis, pleuritis, fever and dermatitis. The common laboratory findings are positive antinuclear antibodies, absence of anti-DNA antibodies, thrombocytopenia, leukopenia and abnormal liver function tests. This LE-like syndrome may appear within days or up to several years after the start of quinidine treatment and disappears completely a few weeks after discontinuation of the drug.
Sukenik
S
S
Department of Internal Medicine A, Soroka Medical Center, Beer Sheva, Israel.
Horowitz
J
J
Katz
A
A
Henkin
J
J
Buskila
D
D
D000368:Aged; D001168:Arthritis / Q000139:chemically induced; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000175:diagnosis; D008875:Middle Aged; D011802:Quinidine / Q000009:adverse effects*
D011802:Quinidine