title: Kinetics of human cone photopigments explained with a Rushton-Henry model.
abstract: Densitrometric measurements of the regeneration of cone visual photopigments have shown effects that cannot be explained by the existing quantitative models. Regeneration from a fully bleached state seems to depend on how this state has been reached and the shape of the regeneration curve cannot be produced by a first order reaction. Rushton and Henry (1968) proposed a store of 11-cis-retinal to explain rapid regeneration after a short bleach. We elaborated this idea into a quantitative model. Regeneration after three different bleach histories and steady state behaviour of the pigments was measured using the Utrecht densitometer. The Rushton-Henry model gives a good fit to the data and is clearly superior to the classical Rushton model in describing densitometric measurements.
authors.affiliation: Royal Netherlands Eye Hospital, Utrecht.
authors.forename: A C
authors.initials: AC
authors.lastname: Coolen
authors.forename: D
authors.initials: D
authors.lastname: van Norren
mesh_terms: D000818:Animals; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D010782:Photolysis; D010786:Photoreceptor Cells / Q000378:metabolism*; D012168:Retinal Pigments / Q000378:metabolism*
chemical_list: D012168:Retinal Pigments