title: The development of human linkage analysis.
abstract: The principles of linkage detection and measurement are traced from the first discovery of linkage to its present-day use in human genetics. Some indications are given of their success and of the present problems and challenges facing them.
authors.affiliation: Galton Laboratory, University College, London.
authors.forename: C A
authors.initials: CA
authors.lastname: Smith
mesh_terms: D002874:Chromosome Mapping; D008040:Genetic Linkage; D005823:Genetics / Q000266:history; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D008126:Lod Score; D008131:London; D011995:Recombination, Genetic