[Combined use of lentinan with X-ray therapy in an experimental mouse tumor system (Part 2). Combined effect on the MM102 syngeneic tumor].
C3H/He mice transplanted syngeneic MM102 tumor subcutaneously in the footpad were used to study the timing of administration of lentinan when combined with local irradiation of X-ray. In combination with 1,000 rads irradiation, the administration of lentinan after X-ray was not effective. When lentinan was administered in combination with 2,000 to 3,000 rads irradiation, the growth of tumor was decreased significantly in comparison with the groups which received radiotherapy alone and those that received lentinan alone. The administration of lentinan before irradiation was effective at the same degree in the group that received lentinan after irradiation. Life prolongation effect was also observed in the group that received lentinan before and after irradiation, and 4 mice among 8 tested mice were survived at 70th day after tumor transplantation.
Shiio
T
T
Life Science Laboratory, Ajinomoto Co. Inc.
Ohishi
K
K
Tsuchiya
Y
Y
Niitsu
I
I
Hayashibara
H
H
Yoshihama
T
T
Moriyuki
H
H
D000818:Animals; D003131:Combined Modality Therapy; D005260:Female; D007912:Lentinan / Q000627:therapeutic use*; D007939:Leukemia L1210 / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D011134:Polysaccharides / Q000627:therapeutic use*; D011879:Radiotherapy Dosage
D011134:Polysaccharides; D007912:Lentinan