title: Tuftsin stimulates growth of HL60 cells.
abstract: Many functions of monocyte/macrophage and granulocyte are activated by tuftsin; principally phagocytosis, motility, immunogenic stimulation, antibacterial and antineoplastic activities. Here it is shown that tuftsin stimulates HL60 growth to twice the control rate. The uptake of [3H]uridine and [3H]leucine in a pulse of 30 min was also double that of the control. The uptake of thymidine was not stimulated.
authors.affiliation: Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.
authors.forename: N J
authors.initials: NJ
authors.lastname: Bump
authors.forename: V A
authors.initials: VA
authors.lastname: Najjar
mesh_terms: D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004261:DNA Replication; D004273:DNA, Neoplasm / Q000096:biosynthesis; D006801:Humans; D007700:Kinetics; D009363:Neoplasm Proteins / Q000096:biosynthesis; D012334:RNA, Neoplasm / Q000096:biosynthesis; D014405:Tuftsin / Q000494:pharmacology*
chemical_list: D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; D014405:Tuftsin