title: Methylglyoxal bis(cyclohexylamidinohydrazone), a novel inhibitor of polyamine biosynthesis that simultaneously inhibits S-adenosylmethionine decarboxylase and spermidine synthase.
authors.affiliation: Department of Biochemistry, Mie University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hibasami
authors.forename: T
authors.initials: T
authors.lastname: Tsukada
authors.forename: S
authors.initials: S
authors.lastname: Maekawa
authors.forename: K
authors.initials: K
authors.lastname: Nakashima
mesh_terms: D012437:Adenosylmethionine Decarboxylase / Q000037:antagonists & inhibitors*; D001667:Binding, Competitive; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D007700:Kinetics; D008935:Mitoguazone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D011073:Polyamines / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D011436:Spermidine Synthase / Q000037:antagonists & inhibitors*; D014166:Transferases / Q000037:antagonists & inhibitors*
chemical_list: D011073:Polyamines; C054653:methylglyoxal bis(cyclohexylamidinohydrazone); D014166:Transferases; D011436:Spermidine Synthase; D002262:Carboxy-Lyases; D012437:Adenosylmethionine Decarboxylase; D008935:Mitoguazone