title: Cephalic phase response of pancreatic exocrine secretion in conscious dogs.
abstract: The effects of three taste solutions on the cephalic phase of pancreatic secretion were studied in conscious dogs. Male beagle dogs weighing 9-11 kg were prepared with gastric and duodenal fistulas. Gustatory receptors were stimulated for 5 min with 100 ml of 0.5% agar solutions containing 0.05, 0.12, and 0.3 M of either sodium chloride, sucrose, or monosodium glutamate (MSG). Pancreatic juice was collected every 5 min before and after stimulation, and volume flow and protein output were measured. Pancreatic secretory responses were found to vary with the type of taste stimulus. Sucrose was a better stimulus than MSG for both protein output and volume flow. Taste stimulation with sodium chloride produced a lower pancreatic response than those with sucrose or MSG.
authors.affiliation: Life Science Laboratory, Central Research Laboratories, Ajinomoto Company, Yokohama, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Ohara
authors.forename: S
authors.initials: S
authors.lastname: Otsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Yugari
mesh_terms: D000818:Animals; D003243:Consciousness; D004285:Dogs; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D012965:Sodium Chloride / Q000494:pharmacology; D012970:Sodium Glutamate / Q000494:pharmacology; D013268:Stimulation, Chemical; D013395:Sucrose / Q000494:pharmacology; D013649:Taste / Q000502:physiology*
chemical_list: D011506:Proteins; D012965:Sodium Chloride; D013395:Sucrose; D012970:Sodium Glutamate