Poorly differentiated, neuron-specific enolase positive round cell tumor with two translocations t(11;22) and t(21;22).
The authors describe a highly malignant, disseminated round cell tumor originating in the ninth rib of a 14-year-old boy. Extensive studies by means of light and electron microscopic examination, histocytochemistry and immunocytochemistry and cytogenetic analysis revealed an undifferentiated, neuron-specific enolase positive round cell tumor with a unique karyotype: 45,XY,-21,t(11;22)(q23;q11), der(22)t(21;22)(q11.2;p11). Thus, despite the absence of definite morphologic features, such as Homer-Wright rosettes, neurosecretory granules and cytoplasmatic processes, these findings suggest a neuroectodermal origin of this bone tumor.
Haas
O A
OA
St. Anna Kinderspital, Vienna, Austria.
Chott
A
A
Ladenstein
R
R
Gadner
H
H
D000293:Adolescent; D001859:Bone Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D002880:Chromosomes, Human, Pair 11; D002891:Chromosomes, Human, Pair 21; D002892:Chromosomes, Human, Pair 22; D003937:Diagnosis, Differential; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009372:Neoplasms, Connective Tissue / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis*; D012512:Sarcoma, Ewing / Q000473:pathology; D014178:Translocation, Genetic
D010751:Phosphopyruvate Hydratase