Temporal pattern of alcohol dehydrogenase gene transcription reproduced by Drosophila stage-specific embryonic extracts.
Regulation of transcription during development has been analysed in vitro using extracts derived from Drosophila embryos. Transcription of mutant templates reveals cis-control regions of the alcohol dehydrogenase promoter responsible for temporal regulation. The activity of a trans-acting protein correlates with the profile of alcohol dehydrogenase expression during embryogenesis.
Heberlein
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U
Howard Hughes Medical Institute, Department of Biochemistry, University of California, Berkeley 94720.
Tjian
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R
D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D004330:Drosophila / Q000196:embryology / Q000235:genetics; D005786:Gene Expression Regulation; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
D000426:Alcohol Dehydrogenase