The locus controlling liver GM1(NeuGc) expression is mapped 1 cM centromeric to H-2K.
The polymorphic variation of liver GM1 (NeuGc) ganglioside was found in inbred strains of the mouse. The genetic analysis using C57BL/10 (GM1-negative) and SWR (GM1-positive) mice revealed that a single autosomal gene (Ggm-1) was involved in the expression of liver GM1(NeuGc) and that C57BL/10 mice lacking GM1(NeuGc) expression carried a defective gene on Ggm-1. Since our previous study on H-2 congenic mice indicated that Ggm-1 was linked to the H-2 complex, in this study we measured recombination frequencies among Ggm-1, Glo-1 and H-2K in the backcross progeny between (C57BL/10 X SWR)F1 and C57BL/10. Ggm-1 was mapped 1 cM centromeric to H-2K on chromosome 17.
Sakaizumi
M
M
Tokyo Metropolitan Institute of Medical Science, Japan.
Hashimoto
Y
Y
Suzuki
A
A
Yamakawa
T
T
Kiuchi
Y
Y
Moriwaki
K
K
D000818:Animals; D002503:Centromere / Q000648:ultrastructure*; D002874:Chromosome Mapping; D002875:Chromosomes / Q000648:ultrastructure*; D005677:G(M1) Ganglioside / Q000235:genetics*; D006183:H-2 Antigens / Q000235:genetics*; D006239:Haplotypes; D008099:Liver / Q000276:immunology* / Q000378:metabolism; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains
D006183:H-2 Antigens; D005677:G(M1) Ganglioside