title: Hypoglossal, trigeminal, and facial motoneuron involvement in amyotrophic lateral sclerosis.
abstract: Facial, trigeminal, and hypoglossal motoneuron involvement was quantified in 25 amyotrophic lateral sclerosis patients and in normal controls. Measures included (1) maximum voluntary contraction of the lower lip, mandible, and tongue using custom-designed force transducers, (2) clinical functions of each muscle group, and in some patients (3) orofacial mobility using videofluoroscopy. All measures indicated that the tongue muscles were most severely affected, even in patients who initially had symptoms in the extremities.
authors.affiliation: Department of Neurology, University of Wisconsin, Madison 53705-2280.
authors.forename: R
authors.initials: R
authors.lastname: DePaul
authors.forename: J H
authors.initials: JH
authors.lastname: Abbs
authors.forename: M
authors.initials: M
authors.lastname: Caligiuri
authors.forename: V L
authors.initials: VL
authors.lastname: Gracco
authors.forename: B R
authors.initials: BR
authors.lastname: Brooks
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology* / Q000503:physiopathology; D005154:Facial Nerve / Q000473:pathology*; D006801:Humans; D007002:Hypoglossal Nerve / Q000473:pathology*; D007568:Jaw / Q000503:physiopathology; D008046:Lip / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000473:pathology*; D009119:Muscle Contraction; D014059:Tongue / Q000503:physiopathology; D014276:Trigeminal Nerve / Q000473:pathology*