title: A review of the methods of chemical synthesis of sulphate and glucuronide conjugates.
abstract: 1. Methods for the synthesis of drug conjugates with sulphuric acid have been reviewed. 2. Some analytical methods are presented for the analysis of sulphate conjugates. 3. The synthesis of several types of N, O and C beta-D-glucuronides is reviewed. Different beta-coupling reactions of protected glucuronides are presented. 4. Application of n.m.r. and mass spectrometry to the analysis of beta-D-glucuronides is discussed.
authors.affiliation: Organon Scientific Development Group, Oss, The Netherlands.
authors.forename: F M
authors.initials: FM
authors.lastname: Kaspersen
authors.forename: C A
authors.initials: CA
authors.lastname: Van Boeckel
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D005965:Glucuronates / Q000032:analysis / Q000138:chemical synthesis*; D013431:Sulfates / Q000032:analysis / Q000138:chemical synthesis*
chemical_list: D005965:Glucuronates; D013431:Sulfates