In vitro activities of LY163892, cefaclor, and cefuroxime.
The in vitro activity of LY163892, a synthetic oral cephalosporin, was compared with those of cefaclor and cefuroxime against 1,193 clinical isolates. MIC ranges and MICs for 50 and 90% of isolates of the three cephalosporins were comparable. The activities of LY163892 and cefaclor were, however, highly inoculum dependent against beta-lactamase-positive Haemophilus influenzae and Staphylococcus aureus; that of cefuroxime was not. LY163892 and cefuroxime appeared stable in microdilution trays stored at 5 and -20 degrees C for 5 weeks, in contrast to cefaclor which remained stable for more than a week only at -5 degrees C.
Knapp
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Department of Microbiology, Cleveland Clinic Foundation, Ohio 44106.
Washington
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D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002433:Cefaclor / Q000494:pharmacology*; D002444:Cefuroxime / Q000494:pharmacology*; D002506:Cephalexin / Q000031:analogs & derivatives*; D002511:Cephalosporins / Q000494:pharmacology*; D004355:Drug Stability; D013696:Temperature
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C054920:loracarbef; D002433:Cefaclor; D002444:Cefuroxime; D002506:Cephalexin