Oligodendroglioma occurring after radiation therapy for pituitary adenoma.
A 38 year old male dentist developed an oligodendroglioma of the left medial temporal lobe and parasellar region 12 years after radiotherapy with 6600 rads of acromegaly. The 30 cases of radiation-induced gliomas reported in the English literature are reviewed and analysed. The criteria for defining radiation-induced tumours of the central nervous system are proposed as follows: the tumour has a long quiescent "latency period", a location in the previously irradiated field, a verified histological difference from a primary condition, and does not arise from a primary condition associated with a genetic syndrome such as neurofibromatosis or tuberous sclerosis. The reported case fulfilled these criteria but appears to be the only reported radiation-induced oligodendroglioma.
Huang
C I
CI
Department of Surgery (Neurosurgery) and Pathology, Veterans General Hospital, Taipei, Taiwan.
Chiou
W H
WH
Ho
D M
DM
D000236:Adenoma / Q000532:radiotherapy*; D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D009837:Oligodendroglioma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D010911:Pituitary Neoplasms / Q000532:radiotherapy*; D011859:Radiography