Hyperglycemic effects of hydrochlorothiazide and propranolol. A biochemical and ultrastructural study.
The authors studied the glycemic disturbances provoked by two antihypertensive drugs, propranolol and hydrochlorothiazide, administered alone or in combination to normal and diabetic rats, using biochemical and ultrastructural parameters. It was found that hydrochlorothiazide raised fasting glucose concentration significantly; propranolol alone caused an insignificant rise of glucose, but significantly aggravated the effect of hydrochlorothiazide with an additive interaction. The ultrastructural findings, as well as the urinary C-peptide excretion, confirmed that the glycemic effects should not be thought to be due to a direct action of the drugs used on the endocrine pancreas.
Papaccio
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Istituto di Anatomia Umana Normale, I Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.
Esposito
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D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002096:C-Peptide / Q000652:urine; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D004357:Drug Synergism; D006442:Glycated Hemoglobin / Q000032:analysis; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000009:adverse effects*; D006943:Hyperglycemia / Q000139:chemically induced*; D007515:Islets of Langerhans / Q000187:drug effects / Q000648:ultrastructure; D008854:Microscopy, Electron; D011433:Propranolol / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D002096:C-Peptide; D006442:Glycated Hemoglobin; D006852:Hydrochlorothiazide; D011433:Propranolol