Induction of ovulation with pulsatile LHRH.
Seven patients with primary or secondary hypogonadotropic amenorrhea and hypothalamic deficits were given LHRH intravenously by a pulsatile pump (Zyklomat-Ferring). 25 treatment cycles were studied: eighteen of them were ovulatory, only one was to be interrupted because of ovarian hyperstimulation. None of the patients had any side effects caused either by the drug or by the means of delivery. The low incidence of multiple pregnancies, the tolerability and the ovulatory response make pulsatile infusion of LHRH a valid alternative to other methods for this kind of subject.
Mattei
A
A
3rd Department of Obstetrics and Gynecology, University of Milan.
Galparoli
C
C
Spellecchia
D
D
Crosignani
P G
PG
D000328:Adult; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D007279:Injections, Subcutaneous; D010062:Ovulation Induction
D007987:Gonadotropin-Releasing Hormone