title: Regional dipyrone nociceptor blockade: a pilot study.
abstract: Eighteen of nineteen patients reported relief from chronic pain (40 to 100%, analogue scale) lasting from a few hours to up to two months after single or repeated regional infusion of dipyrone into a limb. A tendency towards increased duration of pain relief was observed after repeated infusions. The present series of observations in man and experiments with rat paw hyperalgesia are consistent with the interpretation that dipyrone blocks a persistent hyperalgesic state which may result from a previous frequent nociceptive stimulation (memory?) rather than an ongoing inflammatory process.
authors.affiliation: Departamento de Neurologia, Faculdade de Medicina de Uberaba, MG, Brasil.
authors.forename: J O
authors.initials: JO
authors.lastname: Marquez
authors.forename: S H
authors.initials: SH
authors.lastname: Ferreira
mesh_terms: D000632:Aminopyrine / Q000031:analogs & derivatives*; D000698:Analgesia / Q000379:methods*; D000818:Animals; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004177:Dipyrone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007261:Infusions, Intra-Arterial; D009619:Nociceptors / Q000187:drug effects*; D010865:Pilot Projects; D051381:Rats
chemical_list: D000632:Aminopyrine; D004177:Dipyrone