title: Efficacy of a fenbendazole-triclabendazole combination against Fasciola hepatica and gastrointestinal nematodes in sheep.
abstract: A fenbendazole and triclabendazole combination was tested against experimentally induced 6-and 14-week-old infections of Fasciola hepatica and naturally acquired infections of gastrointestinal nematodes in sheep. Forty-eight sheep were divided randomly into six treatment groups of eight animals each. At 7.5 and 10.0 mg kg-1 body weight (BW) (3.75 and 5.0 mg kg-1 BW of each drug), the drug combination was 98.3 and 99.7% effective against 6-week-old F. hepatica infections, and 100 and 99.9% effective against 14-week-old infections. At the same drug dosages, the drug combination was effective against naturally acquired adult Ostertagia spp. (97.3-100%) and adult Nematodirus spp. (90.3-99.9%). No adverse effects associated with treatment were noted.
authors.affiliation: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.
authors.forename: W J
authors.initials: WJ
authors.lastname: Foreyt
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D004338:Drug Combinations; D005210:Fasciola hepatica / Q000187:drug effects; D005211:Fascioliasis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D005273:Fenbendazole / Q000627:therapeutic use*; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary; D008297:Male; D012756:Sheep / Q000469:parasitology; D012757:Sheep Diseases / Q000188:drug therapy*; D014252:Trichostrongyloidiasis / Q000188:drug therapy / Q000662:veterinary*; D000077682:Triclabendazole
chemical_list: D001562:Benzimidazoles; D004338:Drug Combinations; D000077682:Triclabendazole; D005273:Fenbendazole