A 15-kDa interferon-induced protein is derived by COOH-terminal processing of a 17-kDa precursor.
An interferon-induced 15-kDa protein is synthesized from a precursor of higher molecular weight; the precursor contains 165 amino acids (17 kDa), whereas the stable product (15 kDa) contains 156 amino acids. The stable 15-kDa form is derived from the precursor 17-kDa form by the removal of eight amino acids from the COOH terminus and the methionine from the NH2 terminus. The existence of the precursor 17-kDa protein can be demonstrated after brief periods of in vivo labeling with [35S]methionine and by translation of mRNA in vitro.
Knight
E
E
Central Research and Development Department, E. I. du Pont de Nemours and Company, Inc., Wilmington, Delaware 19898.
Fahey
D
D
Cordova
B
B
Hillman
M
M
Kutny
R
R
Reich
N
N
Blomstrom
D
D
D000595:Amino Acid Sequence; D002460:Cell Line; D003488:Cyanogen Bromide; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D014176:Protein Biosynthesis; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000235:genetics
D007370:Interferon Type I; D009363:Neoplasm Proteins; D011506:Proteins; D003488:Cyanogen Bromide