title: Innovative drug delivery systems in cardiovascular medicine: nifedipine-GITS and clonidine-TTS.
abstract: Innovative drug delivery systems have been developed for nifedipine and clonidine that prolong the pharmacologic activity of the medications, allowing once daily dosing. The nifedipine-GITS (gastrointestinal therapeutic system) tablet formulation and the clonidine-TTS (transcutaneous delivery system) patch may also reduce side effects in patients while preserving the therapeutic efficacy of the origin drug formulations (nifedipie capsule, clonidine tablet).
authors.affiliation: Albert Einstein College of Medicine, Bronx, New York.
authors.forename: W H
authors.initials: WH
authors.lastname: Frishman
authors.forename: D
authors.initials: D
authors.lastname: Sherman
authors.forename: D A
authors.initials: DA
authors.lastname: Feinfeld
mesh_terms: D000279:Administration, Cutaneous; D000787:Angina Pectoris / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003000:Clonidine / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D009543:Nifedipine / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D003692:Delayed-Action Preparations; D009543:Nifedipine; D003000:Clonidine