title: [Acute lymphoblastic leukemia, Burkitt-cell type, after Hodgkin's disease. Study of 2 cases].
abstract: Two cases of Burkitt cell leukaemia (ALL3) occurring 60 and 51 months respectively after treatment of Hodgkin's disease (HD) are described. Clinical, cytological, immunological and cytogenetic features in these patients were comparable with those of the 6 previously published cases and with de novo ALL3. The prognosis of these secondary ALL3 is uniformly poor: our 2 patients died 2 and 14 days after the start of combination chemotherapy, and all the other cases survived less than 60 days after diagnosis. The significance of ALL3 occurring after HD is discussed: the association is probably not fortuitous, and its pathogenic mechanisms probably differ from those intervening in secondary myeloid leukaemias.
authors.affiliation: Laboratoire d'Hématologie, Hôpital Calmette, Lille, France.
authors.forename: M
authors.initials: M
authors.lastname: Zandecki
authors.forename: B
authors.initials: B
authors.lastname: Dupriez
authors.forename: J L
authors.initials: JL
authors.lastname: Laï
authors.forename: P
authors.initials: P
authors.lastname: Fenaux
authors.forename: T
authors.initials: T
authors.lastname: Facon
authors.forename: P
authors.initials: P
authors.lastname: Lepelley
authors.forename: M H
authors.initials: MH
authors.lastname: Estienne
authors.forename: J J
authors.initials: JJ
authors.lastname: Huart
authors.forename: J P
authors.initials: JP
authors.lastname: Jouet
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage; D009378:Neoplasms, Multiple Primary; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D011241:Prednisone
vernacular_title: Leucémie aiguë lymphoblastique à cellules de Burkitt après maladie de Hodgkin. Etude de deux observations.