title: Left ventricular thromboembolic occlusion of the popliteal artery treated nonoperatively with local urokinase infusion--a case report.
abstract: Recently streptokinase and urokinase have been shown to be useful in the nonoperative treatment of thromboembolic disease. Urokinase is emerging as a safer and more effective thrombolytic agent when applied either to definitively lyse spontaneous thrombosis where no underlying structural lesion is present or to serve as an adjunct prior to surgical reconstruction or transluminal angioplasty. The authors report a case of a high-risk cardiac patient in whom an embolic occlusion of the distal popliteal artery was completely recanalized by using a localized catheter infusion of urokinase. The source of the embolus was a left ventricular thrombus. No serious bleeding or proximal or distal embolic complications occurred. The potential hazards of fragmentation of the embolic source in the presence of systemic thrombolysis, distal trifurcation embolization, and concomitant use of heparin are reviewed.
authors.affiliation: Department of Radiology, Hennepin County Medical Center, Minneapolis, MN.
authors.forename: I D
authors.initials: ID
authors.lastname: Weisman
authors.forename: W R
authors.initials: WR
authors.lastname: Stanchfield
authors.forename: C A
authors.initials: CA
authors.lastname: Herzog
authors.forename: A L
authors.initials: AL
authors.lastname: Ney
authors.forename: D P
authors.initials: DP
authors.lastname: Blake
mesh_terms: D000792:Angiography; D004617:Embolism / Q000188:drug therapy*; D006331:Heart Diseases / Q000150:complications*; D006352:Heart Ventricles; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011150:Popliteal Artery / Q000000981:diagnostic imaging; D013927:Thrombosis / Q000150:complications*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D006493:Heparin; D014568:Urokinase-Type Plasminogen Activator