title: Appearance of an inherited porphyria cutanea tarda in a child after allogeneic bone marrow transplantation for chronic myelogenous leukaemia.
abstract: We report details of a 6 1/2-year-old girl who developed porphyria cutanea tarda after allogeneic bone marrow transplantation for chronic myelogenous leukaemia. The results of studying porphyrin metabolism in the family members are described. Expression of the disease may have been induced by the cyclophosphamide and total-body irradiation in the conditioning regimen and/or by the administration of methotrexate for the prevention of graft-versus-host disease and meningeal leukaemia.
authors.affiliation: Department of Pediatric Hematology and Oncology, University Childrens Hospital, Tübingen, Federal Republic of Germany.
authors.forename: R
authors.initials: R
authors.lastname: Dopfer
authors.forename: M
authors.initials: M
authors.lastname: Doss
authors.forename: G
authors.initials: G
authors.lastname: Ehninger
authors.forename: P
authors.initials: P
authors.lastname: Ostendorf
authors.forename: D
authors.initials: D
authors.lastname: Niethammer
mesh_terms: D016026:Bone Marrow Transplantation; D002648:Child; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D008297:Male; D011164:Porphyrias / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D011166:Porphyrins / Q000096:biosynthesis / Q000652:urine; D012871:Skin Diseases / Q000209:etiology* / Q000235:genetics / Q000378:metabolism
chemical_list: D011166:Porphyrins