Cerebral vasospasm.
Cerebral vasospasm is an important component of pathological entities such as migraine, subarachnoid hemorrhage (SAH), head trauma, post cerebral ischemia and/or hypoxia. The mechanisms underlying cerebral vasospasm in these diseases are not completely understood. Neurochemical and morphological factors involved in the cerebral circulation control are reviewed in this article. The circulatory changes observed after subarachnoid hemorrhage are taken as a model. It is concluded that multiple biochemical, physiological and morphological factors are involved in the cerebral vascular responses after SAH. Possible treatment alternatives for cerebral vasospasm based on its etiology are discussed.
De Salles
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Department of Physiology, Medical College of Virginia.
D002118:Calcium / Q000494:pharmacology; D002395:Catecholamines / Q000494:pharmacology; D002560:Cerebrovascular Circulation; D006801:Humans; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D011453:Prostaglandins / Q000494:pharmacology; D013345:Subarachnoid Hemorrhage / Q000150:complications; D014661:Vasoconstriction
D002395:Catecholamines; D011453:Prostaglandins; D002118:Calcium