title: The value of indium-labelled leucocytes in clinical practice.
abstract: Following intravenous injection, autologous 111In labelled-leucocytes migrate to sites of inflammation, where they can be imaged with the gamma camera. The principle underlining the labelling technique is exposure of a population of leucocytes or purified granulocytes to a lipophilic 111In complex, such as 111In oxine or 111In tropolonate. As a result of cell activation, the in vitro manipulation to which the leucocytes are subjected modifies their biodistribution early after re-injection. Separation and labelling in plasma-enriched media, however, limits this activation and promotes early migration into inflammatory foci.
authors.affiliation: Royal Postgraduate Medical School, London.
authors.forename: A M
authors.initials: AM
authors.lastname: Peters
authors.forename: S H
authors.initials: SH
authors.lastname: Saverymuttu
mesh_terms: D006801:Humans; D007205:Indium Radioisotopes; D007249:Inflammation / Q000000981:diagnostic imaging*; D007962:Leukocytes / Q000276:immunology*; D011877:Radionuclide Imaging
chemical_list: D007205:Indium Radioisotopes