title: New suggestions for the physiological role of secretory protein-I.
abstract: A major endocrine secretory protein of unknown function termed secretory protein-I or, alternatively, chromogranin A, is attracting increasing attention. Because of its abundance and apparently universal presence in endocrine and neuroendocrine cells, many suggestions for a physiological role have been advanced. Recent data provide the first firm bases for some proposed functions that include a regulator of a novel protease capable of converting prohormones to hormones, a hormone precursor, and through its calcium-binding and aggregating properties, a secretory granule condensing protein.
authors.affiliation: Department of Oral Biology, University of Louisville, KY 40292.
authors.forename: S U
authors.initials: SU
authors.lastname: Gorr
authors.forename: R
authors.initials: R
authors.lastname: Kumarasamy
authors.forename: W L
authors.initials: WL
authors.lastname: Dean
authors.forename: D V
authors.initials: DV
authors.lastname: Cohn
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D053379:Chromogranin A; D002864:Chromogranins / Q000502:physiology*; D003594:Cytoplasmic Granules / Q000502:physiology; D006728:Hormones; D009419:Nerve Tissue Proteins / Q000502:physiology*; D010447:Peptide Hydrolases / Q000378:metabolism; D011498:Protein Precursors
chemical_list: D053379:Chromogranin A; D002864:Chromogranins; D006728:Hormones; D009419:Nerve Tissue Proteins; D011498:Protein Precursors; D010447:Peptide Hydrolases; D002118:Calcium