Buprenorphine as premedication and as analgesic during and after light isoflurane-N2O-O2 anaesthesia. A comparison with oxycodone plus fentanyl.
Sixty patients undergoing gynaecological laparotomies under isoflurane anaesthesia received 0.4 mg of buprenorphine sublingually or 0.12 mg/kg of oxycodone intramuscularly in random order for preanaesthetic medication. Patients premedicated with buprenorphine were given buprenorphine before, during and after anaesthesia and patients premedicated with oxycodone received fentanyl before and during anaesthesia and oxycodone after anaesthesia. Buprenorphine premedication produced less drowsiness and sedation and alleviated patients' apprehension significantly (P less than 0.05) less than oxycodone. Systolic and diastolic blood pressure and heart rate were significantly (P less than 0.05 to P less than 0.01) higher after intubation in the buprenorphine group when compared with the oxycodone plus fentanyl group. After anaesthesia, spontaneous respiration started rapidly; the return of consciousness and immediate recovery occurred at the same rate in both groups. In the recovery room moderate to severe pain was more common (P less than 0.05) in the oxycodone plus fentanyl group than in the buprenorphine group. The respiratory rate in the recovery room was lower among patients given buprenorphine, and two patients given buprenorphine developed severe respiratory depression. In the ward (2 to 24 h after operation) sublingual buprenorphine provided pain relief as good as intramuscularly administered oxycodone. No differences were noted in the incidence or severity of emetic symptoms between the groups. It is concluded that buprenorphine can provide good postoperative pain relief for gynaecological laparotomies performed under light isoflurane anaesthesia, but patients need to be monitored carefully after operation because of the possibility of respiratory depression.
Korttila
K
K
Department of Anaesthesia, Women's Clinics, Helsinki University Central Hospital, Finland.
Hovorka
J
J
D000328:Adult; D000698:Analgesia; D000770:Anesthesia, Endotracheal; D000768:Anesthesia, General; D002047:Buprenorphine / Q000008:administration & dosage / Q000009:adverse effects; D002986:Clinical Trials as Topic; D003061:Codeine / Q000031:analogs & derivatives; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D007530:Isoflurane; D009609:Nitrous Oxide; D010098:Oxycodone / Q000008:administration & dosage / Q000009:adverse effects; D010149:Postoperative Pain / Q000517:prevention & control; D011292:Premedication; D011897:Random Allocation; D012119:Respiration / Q000187:drug effects
D002047:Buprenorphine; D010098:Oxycodone; D007530:Isoflurane; D009609:Nitrous Oxide; D005283:Fentanyl; D003061:Codeine