title: Topical application of human fibroblast interferon (IFN) in cutaneous leishmaniasis.
abstract: Fifteen patients with single or multiple lesions of cutaneous leishmaniasis were randomly assigned to apply either IFN-beta-containing cream or a placebo cream base. Despite 8 weeks of therapy no significant improvement of the lesions was achieved. Although topical IFN-beta was not effective in this study, several laboratory studies suggest that IFN, particularly IFN-gamma, may be of therapeutic value in cutaneous leishmaniasis.
authors.affiliation: Department of Dermatology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: H
authors.initials: H
authors.lastname: Trau
authors.forename: M
authors.initials: M
authors.lastname: Schewach-Millet
authors.forename: J
authors.initials: J
authors.lastname: Shoham
authors.forename: T
authors.initials: T
authors.lastname: Doerner
authors.forename: R
authors.initials: R
authors.lastname: Shor
authors.forename: J H
authors.initials: JH
authors.lastname: Passwell
mesh_terms: D000287:Administration, Topical; D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage / Q000627:therapeutic use*; D007896:Leishmaniasis / Q000628:therapy*; D008297:Male; D011897:Random Allocation
chemical_list: D007370:Interferon Type I