title: Endogenous inhibitor of ecdysone synthesis in crabs.
abstract: Attempts to isolate the molt-inhibiting hormone (MIH) of crustaceans from crab eyestalks (ES) resulted in the characterization of xanthurenic acid as an inhibitor of ecdysone biosynthesis in the cultured Y-organ-complex (YOC) homogenate. It was also found that 3-hydroxy-L-kynurenine present in the ES is transformed into xanthurenic acid in the YOC and body fluid. Its mode of inhibitory action in ecdysone biosynthesis is probably inactivation of cytochrome P-450.
authors.affiliation: Suntory Institute for Bioorganic Research, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Naya
authors.forename: K
authors.initials: K
authors.lastname: Kishida
authors.forename: M
authors.initials: M
authors.lastname: Sugiyama
authors.forename: M
authors.initials: M
authors.lastname: Murata
authors.forename: W
authors.initials: W
authors.lastname: Miki
authors.forename: M
authors.initials: M
authors.lastname: Ohnishi
authors.forename: K
authors.initials: K
authors.lastname: Nakanishi
mesh_terms: D000818:Animals; D003386:Brachyura / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D046508:Culture Techniques; D004440:Ecdysone / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D005123:Eye / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D007447:Invertebrate Hormones / Q000302:isolation & purification; D007737:Kynurenine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000378:metabolism; D014977:Xanthurenates / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D007447:Invertebrate Hormones; D014977:Xanthurenates; C012445:molt-inhibiting hormone; C005045:3-hydroxykynurenine; D007737:Kynurenine; D004440:Ecdysone; C028330:xanthurenic acid