title: Temperature-sensitive growth mutants as live vaccines against experimental murine salmonellosis.
abstract: Temperature-sensitive growth mutants of Salmonella enteritidis, NUB 209 and NUB 323, characterized as protein synthesis mutants, were unable to proliferate at 37 C and lost the parent's virulence. In mice, these mutants conferred high levels of protection as live vaccines. Although the vaccination effect of NUB 323 was not so good as that of NUB 209, NUB 323 was preferred as a safer live vaccine because this mutant was completely avirulent and no back mutation appeared.
authors.affiliation: Department of Bacteriology, Nagoya University School of Medicine, Aichi.
authors.forename: M
authors.initials: M
authors.lastname: Ohta
authors.forename: N
authors.initials: N
authors.lastname: Kido
authors.forename: Y
authors.initials: Y
authors.lastname: Fujii
authors.forename: Y
authors.initials: Y
authors.lastname: Arakawa
authors.forename: T
authors.initials: T
authors.lastname: Komatsu
authors.forename: N
authors.initials: N
authors.lastname: Kato
mesh_terms: D000818:Animals; D051379:Mice; D009154:Mutation; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000517:prevention & control*; D012477:Salmonella enteritidis / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity; D013696:Temperature; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D014774:Virulence
chemical_list: D014613:Vaccines, Attenuated