title: Evidence against an immunogenetic basis for diabetes in chronic pancreatitis.
abstract: A possible immunogenetic basis for diabetes in chronic pancreatitis was explored by studying 19 patients with both disorders, most of whom required treatment with insulin. In contrast to patients with insulin-dependent (Type 1) diabetes, patients with diabetes and chronic pancreatitis had residual beta cell function but blunted C-peptide responses to intravenous glucagon, absence of circulating islet cell antibodies, and HLA-DR types similar to control subjects and patients with chronic pancreatitis without diabetes. Diabetes complicating chronic pancreatitis is therefore not associated with the biochemical or immunogenetic markers characteristic of Type 1 diabetes.
authors.affiliation: Department of Diabetes & Endocrinology, Royal Melbourne Hospital, Vic.
authors.forename: P G
authors.initials: PG
authors.lastname: Colman
authors.forename: C G
authors.initials: CG
authors.lastname: Begley
authors.forename: B D
authors.initials: BD
authors.lastname: Tait
authors.forename: I C
authors.initials: IC
authors.lastname: Roberts-Thomson
authors.forename: L C
authors.initials: LC
authors.lastname: Harrison
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D002908:Chronic Disease; D003593:Cytoplasm / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D001786:Blood Glucose; D002096:C-Peptide; D006684:HLA-DR Antigens