Similarity between the estrogen receptor and the DNA-binding domain of the tetracycline repressor.
The amino-terminus region of tetracycline (tet) repressors contains a helix-turn-helix structure that binds to DNA. A computer-based comparison of a residues 18-61 of the tet repressor, which contains this DNA-binding domain, with a residues 304-347 of the human estrogen receptor (ER) yields a score that is 6.7 standard deviations higher than that obtained with 2,500 comparisons of randomized sequences of these segments. The probability of getting this score by chance is less than 10(-11). This part of the ER could be important in nuclear actions of ER in target tissues.
Baker
M E
ME
Department of Medicine, University of California, San Diego, La Jolla 92093.
D000595:Amino Acid Sequence; D004247:DNA / Q000378:metabolism*; D008969:Molecular Sequence Data; D011960:Receptors, Estrogen; D012097:Repressor Proteins; D012984:Software; D013752:Tetracycline; D014157:Transcription Factors
D011960:Receptors, Estrogen; D012097:Repressor Proteins; D014157:Transcription Factors; D004247:DNA; D013752:Tetracycline