[Combination use of lentinan with X-ray therapy in a mouse experimental tumor system (Part I). Basic studies].
Apparent reduction of leukocyte counts was observed in mice irradiated with 1,500 approximately 3,000 rads of X-ray on the left hind leg. This reduction of leukocyte counts was completely protected by the pre-treatment with lentinan before X-ray irradiation. Suppressive effect of X-ray on the antitumor function of lentinan seems to be weak. When treatment with X-ray irradiation and lentinan was applied for mice bearing solid type sarcoma 180, additive effect was obtained by the combination of lentinan before or after X-ray irradiation.
Shiio
T
T
Life Science Laboratory, Central Research Laboratories, Ajinomoto Co. Inc.
Tsuchiya
Y
Y
Ohishi
K
K
Yoshihama
T
T
D000818:Animals; D003131:Combined Modality Therapy; D005260:Female; D007912:Lentinan / Q000008:administration & dosage*; D007970:Leukopenia / Q000517:prevention & control*; D051379:Mice; D008813:Mice, Inbred ICR; D011134:Polysaccharides / Q000008:administration & dosage*; D011879:Radiotherapy Dosage; D012074:Remission Induction; D012510:Sarcoma 180 / Q000473:pathology / Q000532:radiotherapy*
D011134:Polysaccharides; D007912:Lentinan