title: Hematologic and serum biochemical alterations associated with multiple halothane anesthesia exposures and minor surgical trauma in horses.
abstract: Five horses were anesthetized similarly by use of xylazine, guaifenesin, thiamylal sodium, and halothane in oxygen on 3 consecutive days, and minor surgical procedures were performed. For 1 to 10 days after the last anesthetic exposure, clinical, hematologic, and serum biochemical features were monitored, and after necropsy, histologic examination of major organ tissues was performed. Predominant hematologic changes from base-line values included leukocytosis (maximal at 27 hours, 10,500 +/- 1,750 cells/microliter), neutrophilia (maximal at 51 hours, 7,485 +/- 1,719 cells/microliter), and lymphopenia (minimal at 51 hours, 1,636 +/- 564 cells/microliter). Alterations observed in other clinicopathologic features were minor and indicative of mild renal disturbance and nonspecific cellular necrosis. Histopathologic lesions in the liver were mild.
authors.affiliation: Department of Anatomy, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: S M
authors.initials: SM
authors.lastname: Stover
authors.forename: E P
authors.initials: EP
authors.lastname: Steffey
authors.forename: N O
authors.initials: NO
authors.lastname: Dybdal
authors.forename: C E
authors.initials: CE
authors.lastname: Franti
mesh_terms: D000768:Anesthesia, General / Q000662:veterinary*; D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D005260:Female; D006221:Halothane; D006734:Horse Diseases / Q000097:blood* / Q000473:pathology; D006736:Horses / Q000097:blood / Q000601:surgery*; D007958:Leukocyte Count / Q000662:veterinary; D007964:Leukocytosis / Q000662:veterinary; D008099:Liver / Q000473:pathology; D008231:Lymphopenia / Q000662:veterinary; D008297:Male; D009504:Neutrophils; D011183:Postoperative Complications / Q000097:blood / Q000473:pathology / Q000662:veterinary*
chemical_list: D006221:Halothane