title: Acute idiopathic blind spot enlargement. A big blind spot syndrome without optic disc edema.
abstract: We examined seven patients who had a syndrome of symptomatic monocular blind spot enlargement without optic disc edema. Two patients had previous blind spot enlargement that resolved over several months. The scotoma in each patients was absolute, measured 15 degrees to 20 degrees in diameter, had steep geographic margins, and extended to within 5 degrees to 10 degrees of fixation. Typically, patients had normal visual acuity, color vision, pupillary responses, and ophthalmoscopic findings. Photostress recovery, tested in two patients, was prolonged in the affected eye. Fluorescein angiography showed no abnormalities corresponding to the scotoma. Orbital computed tomographic scans in three patients and visual evoked responses in one patient were normal. Multifocal electroretinography, performed in two patients, showed loss of retinal waveforms in a large region surrounding the optic disc. Our findings suggest that retinal dysfunction produces this big blind spot syndrome, but we do not know its cause.
authors.affiliation: Department of Neurological Surgery, School of Medicine, University of California, San Francisco 94143.
authors.forename: W A
authors.initials: WA
authors.lastname: Fletcher
authors.forename: R K
authors.initials: RK
authors.lastname: Imes
authors.forename: D
authors.initials: D
authors.lastname: Goodman
authors.forename: W F
authors.initials: WF
authors.lastname: Hoyt
mesh_terms: D000208:Acute Disease; D000328:Adult; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D009898:Optic Disk / Q000473:pathology*; D010211:Papilledema / Q000473:pathology; D012607:Scotoma / Q000473:pathology* / Q000503:physiopathology; D013577:Syndrome; D014792:Visual Acuity