[What has become of preliminary transfusion protocols in kidney transplantation?].
Many studies have demonstrated that pretransplant blood transfusions improved cadaver kidney graft outcome. The nature and the frequency of transfusions-induced lymphocytotoxic antibodies depends of sex, previous pregnancies and kidney grafts, and transfusional patterns. This provoked immunisation is not a hindrance to beneficial effects of transfusions. Numerous reports have investigated the responsible mechanism for this effect. Controversial data concern the optimum number of blood units. In a previous prospective study in patients who received anti-lymphocyte globulins as part of immunosuppressive therapy, we have shown that a multiple transfusions policy does not give better results than only one. Recently, the beneficial effect of transfusions has been questioned, either entirely, or for particular patients according to age, sex, immunosuppressive treatment including cyclosporin or not. This leaded us to reassess benefits of transfusions.
Cartier
F
F
Centre de Transplantation, Hôpital Pontchaillou, Rennes, France.
Launois
B
B
Campion
J P
JP
Chapuis
B
B
Fauchet
R
R
D001803:Blood Transfusion; D006085:Graft Survival; D006801:Humans; D007114:Immunization; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D014181:Transplantation Immunology
Quel est le devenir des protocoles transfusionnels préalables à la transplantation rénale?