Evaluation of a therapeutic concentration of dithranol in the mouse-tail test.
A study of dithranol ointment in the mouse-tail test showed that 0.2% dithranol ointment induced a granular layer and orthokeratosis in mouse-tail epidermis. This provides further evidence of the value of the mouse-tail test in evaluating anti-psoriatic activity of topical preparations.
Hofbauer
M
M
Institute of Dermatology, United Medical School, London, U.K.
Dowd
P M
PM
Atkinson
J
J
Whitefield
M
M
Greaves
M W
MW
D000818:Animals; D000875:Anthralin / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D011565:Psoriasis / Q000139:chemically induced / Q000188:drug therapy; D011897:Random Allocation; D012867:Skin / Q000187:drug effects*
D000875:Anthralin