title: Primary structure of the met protein tyrosine kinase domain.
abstract: The primary structure of the protein tyrosine kinase domain of the human met gene has been determined from cDNA clones prepared from transcripts of the activated human met gene. These analyses reveal that the met kinase domain (located on human chromosome 7) possesses unique features that distinguish met from other members of the src family of protein tyrosine kinases. The results also demonstrate that the product of the activated met gene is a fusion protein and that the amino terminal end of this fusion protein, which is encoded by human chromosome 1, exhibits homology to laminin B1.
authors.affiliation: Institute of Cancer Research, Chester Beatty Laboratories, London, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Chan
authors.forename: H W
authors.initials: HW
authors.lastname: King
authors.forename: P R
authors.initials: PR
authors.lastname: Tempest
authors.forename: E A
authors.initials: EA
authors.lastname: Deakin
authors.forename: C S
authors.initials: CS
authors.lastname: Cooper
authors.forename: P
authors.initials: P
authors.lastname: Brookes
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D006801:Humans; D007797:Laminin / Q000235:genetics; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics
chemical_list: D007797:Laminin; D011518:Proto-Oncogene Proteins; D004247:DNA; D011505:Protein-Tyrosine Kinases