Effect of continuous illumination on secretion of pregnane compounds by the rat ovary.
Differences in the secretion of pregnane compounds from rats with follicular polycystic ovaries under constant light and with normal preovulatory ovaries under light-dark conditions were compared. The injection of LH greatly increased the secretion of progesterone. 5 alpha-pregnane-3,20-dione and 3 alpha-hydroxy-5 alpha-pregnan-20-one, in both types of ovaries, but the response of the two progesterone metabolites in the polycystic ovaries was low, suggesting low 5 alpha-reductase activity.
Kosaka
T
T
Department of Animal Reproduction, College of Agriculture, University of Osaka Prefecture, Japan.
Sawada
T
T
Ichikawa
S
S
D000818:Animals; D004971:Estrus / Q000528:radiation effects; D005260:Female; D008027:Light; D007986:Luteinizing Hormone / Q000494:pharmacology; D010053:Ovary / Q000378:metabolism* / Q000473:pathology / Q000528:radiation effects; D011085:Polycystic Ovary Syndrome / Q000473:pathology / Q000503:physiopathology*; D011278:Pregnanes / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D011278:Pregnanes; D011374:Progesterone; D007986:Luteinizing Hormone