Genotoxicity of epoxy resin hardeners in the hepatocyte primary culture/DNA repair test.
The genotoxicity of 9 chemicals used as epoxy resin hardeners was examined in the DNA repair test with rat hepatocytes. DNA repair synthesis was elicited by 7 chemicals, i.e., 4-aminodiphenyl ether, 4,4-diaminodiphenyl ether, 3,4,4'-triaminodiphenyl ether, 3,3'-dichloro-4,4'-diaminodiphenyl ether, 1,3-phenylenedi-4-aminophenyl ether, 4,4'-diaminodiphenyl methane and 4,4'-methylene-bis(2-chloroaniline). The positive results obtained with 4 epoxy resin hardeners of unknown carcinogenicity, i.e., 4-amino-diphenyl ether, 3,4,4'-triaminodiphenyl ether, 3,3'-dichloro-4,4'-diaminodiphenyl ether and 1,3-phenylene-di-4-aminophenyl ether suggest that they may be carcinogens. The genotoxicity of 1,4-phenylene-di-4-aminophenyl ether, of unknown carcinogenicity, and 4,4'-diaminodiphenyl sulfone, for which there is no sound proof of carcinogenicity, was not confirmed in the DNA repair test. The result with 4,4'-diaminodiphenyl sulfone was in agreement with its lack of mutagenicity in Salmonella typhimurium.
Mori
H
H
Department of Pathology, Gifu University School of Medicine, Japan.
Yoshimi
N
N
Sugie
S
S
Iwata
H
H
Kawai
K
K
Mashizu
N
N
Shimizu
H
H
D000818:Animals; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair / Q000187:drug effects*; D004853:Epoxy Resins; D066298:In Vitro Techniques; D008099:Liver; D008297:Male; D009152:Mutagenicity Tests; D010647:Phenyl Ethers / Q000633:toxicity*; D051381:Rats
D004853:Epoxy Resins; D010647:Phenyl Ethers; D004247:DNA