Effect of anticonvulsants on human chromosomes. 2. In vitro studies.
The effects of 3 anticonvulsant drugs (diphenylhydantoin, ethosuximide, and phenobarbital) on human peripheral lymphocytes in vitro were studied. The rate of chromosomal aberrations induced by the 3 anticonvulsants was significantly increased from the first concentration analyzed, similar to half the therapeutic serum concentration. These findings are compared with other previous reports.
García Sagredo
J M
JM
Servicio de Genética Médica, Hospital Ramón y Cajal, Madrid, Spain.
D000927:Anticonvulsants / Q000494:pharmacology*; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects*; D005013:Ethosuximide / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010634:Phenobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology
D000927:Anticonvulsants; D005013:Ethosuximide; D010672:Phenytoin; D010634:Phenobarbital