[The role of IgE in recurrent ORL infections in children].
The high incidence of bacterial super-infection in atopic individuals has long been known, especially in asthma and atopic dermatitis. In recurrent ENT infections in children, increased IgE levels are found in half the cases; this increase results from two main mechanisms: a predisposition to allergy (often with positive RASTs), and certain viral infections: respiratory syncytial virus, para-influenzae, and measles, that trigger production of partly non-specific serum IgEs. In the latter situation, the increased IgE levels are both a cause and a consequence of recurrent infections. More recently, in some forms of atopic dermatitis (infant and Buckley syndrome), attention has been drawn to the severity of viral superinfections (herpes, chickenpox, vaccine), which is directly correlated with the IgE levels. The mechanism of such infections is unclear: the local increase in IgE levels is responsible for degranulation of mastocytes which in turn results in edema, fissures of mucosae and congestion; an effect on the lymphocytic response is possible, with inhibition of the production of certain lymphokines, especially interleukins.
Reinert
P
P
Service de Pédiatrie, Centre Hospitalier Intercommunal, Créteil.
Bernaudin
F
F
Lobut
J B
JB
Doppelt
E
E
de La Rocque
F
F
Lemerle
S
S
D000393:Air Pollutants; D001424:Bacterial Infections / Q000209:etiology / Q000378:metabolism*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism*; D007223:Infant; D008297:Male; D010038:Otorhinolaryngologic Diseases / Q000209:etiology / Q000378:metabolism*; D011446:Prospective Studies; D012008:Recurrence
D000393:Air Pollutants; D007073:Immunoglobulin E
Rôle des IgE dans les infections ORL récidivantes de l'enfant.