Age dependent effect of toxic and detoxified endotoxins on the natural anti-DNA antibody level in rats.
Toxic endotoxin (LPS) and its irradiated detoxified form (RD-LPS) induced only small changes in the DNA level in the sera of 4, 12 and 18 months old rats. Changes in the anti-DNA titres were age-dependent. In 4 months old rats one or two injections of the LPS preparations failed to increase the circulating anti-DNA level. In 12 and 18 months old rats both toxic and detoxified LPS preparations raised the anti-DNA titres. The second LPS injection evoked a smaller response in 18 months old rats than the first one.
Elekes
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Frédéric Joliot-Curie National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary.
Merétey
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Bertók
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D000375:Aging; D000818:Animals; D000974:Antibodies, Antinuclear / Q000096:biosynthesis*; D004247:DNA / Q000096:biosynthesis / Q000276:immunology*; D004277:DNA, Single-Stranded / Q000096:biosynthesis / Q000276:immunology; D004731:Endotoxins / Q000494:pharmacology* / Q000528:radiation effects; D004926:Escherichia coli; D005260:Female; D005720:Gamma Rays; D008070:Lipopolysaccharides / Q000494:pharmacology / Q000528:radiation effects; D008297:Male; D051381:Rats
D000974:Antibodies, Antinuclear; D004277:DNA, Single-Stranded; D004731:Endotoxins; D008070:Lipopolysaccharides; D004247:DNA