Effects of antiepileptic drugs in electrophysiological tests.
Methods of the study of antiepileptic drugs activity by means of analysis of their effects on bioelectrical ictal phenomena in the animal brain are described. The paper deals especially with EEG signal processing methods. Application of various nonparametric models (e.g. interval-amplitude scatter plots, power spectra analysis) as well as parametric models (e.g. autoregressive model, segmentation analysis) is discussed. A discriminative approach to some of these methods (especially to autoregressive model) is also presented. Special attention is stressed on the value of these methods for the study of anticonvulsant drugs activity.
Rump
S
S
Department of Pharmacology, Military Institute of Hygiene and Epidemiology, Warszawa, Poland.
Kowalczyk
M
M
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004594:Electrophysiology / Q000379:methods; D006801:Humans; D012640:Seizures / Q000503:physiopathology
D000927:Anticonvulsants