title: Our experience of conservative treatment of anal canal carcinoma combining external irradiation and interstitial implant: 32 cases treated between 1973 and 1982.
abstract: Between 1973 and 1982, a selected group of 32 patients with anal canal carcinoma received conservative treatment combining external irradiation and 192Iridium implant in a split course. Survival rates at 3 and 5 years are 78 and 61%, respectively. The overall control rate at the primary site is 75%. Tumor response to external irradiation appears to be the major predicting factor of the primary growth control after subsequent interstitial therapy. Two patients (6%) showed severe radionecrosis. The probability to preserve good anal function is 69%. Interstitial irradiation preceded by an external radiotherapy offers a good alternative in the conservative treatment of anal canal carcinoma.
authors.affiliation: Fondation Bergonié, Bordeaux, France.
authors.forename: N Y
authors.initials: NY
authors.lastname: Ng Ying Kin
authors.forename: J
authors.initials: J
authors.lastname: Pigneux
authors.forename: H
authors.initials: H
authors.lastname: Auvray
authors.forename: R
authors.initials: R
authors.lastname: Brunet
authors.forename: L
authors.initials: L
authors.lastname: Thomas
authors.forename: R
authors.initials: R
authors.lastname: Denepoux
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001005:Anus Neoplasms / Q000532:radiotherapy*; D001918:Brachytherapy; D002277:Carcinoma / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007496:Iridium Radioisotopes; D008297:Male; D008875:Middle Aged
chemical_list: D007496:Iridium Radioisotopes