title: Subthreshold atrial pacing in patients with a left-sided accessory pathway: an effective new method for terminating reciprocating tachycardia.
abstract: This study investigated the possibility of terminating reciprocating atrioventricular (AV) tachycardia using subthreshold atrial pacing. Ten patients with a left-sided accessory pathway and sustained AV tachycardia underwent subthreshold atrial pacing from the coronary sinus site closest to insertion of the accessory pathway. In seven of these patients, the tachycardia could be reliably terminated with subthreshold atrial overdrive pacing. When pacing at a cycle length of 80 +/- 23% of the tachycardia cycle length, the minimal subthreshold current that was effective in tachycardia termination was 64 +/- 14% of threshold current and the maximal ineffective current was 49 +/- 17% of threshold (p less than 0.05). In all cases, the tachycardia was terminated by one or two instances of atrial capture that resulted in a premature atrial impulse (20 +/- 4% advancement of the atrial cycle) that blocked the AV node limb of the tachycardia. Anterograde conduction over the accessory pathway never occurred, either during the tachycardia or during subthreshold pacing after a return to normal sinus rhythm. No instances of atrial fibrillation were provoked by subthreshold pacing. Possible explanations for the intermittent atrial capture with critically placed subthreshold impulses include supernormal atrial conduction or summation of impulses at the atrial insertion site of the accessory pathway. It is concluded that subthreshold pacing is effective in selected patients with AV tachycardia due to an accessory pathway. Furthermore, because neither atrial fibrillation nor anterograde conduction over the accessory pathway is seen with subthreshold pacing, this modality may hold significant promise for permanent antitachycardia pacing in these patients.
authors.affiliation: Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California 90048.
authors.forename: E S
authors.initials: ES
authors.lastname: Gang
authors.forename: T
authors.initials: T
authors.lastname: Peter
authors.forename: P C
authors.initials: PC
authors.lastname: Nalos
authors.forename: M
authors.initials: M
authors.lastname: Meesmann
authors.forename: H S
authors.initials: HS
authors.lastname: Karagueuzian
authors.forename: W J
authors.initials: WJ
authors.lastname: Mandel
authors.forename: D S
authors.initials: DS
authors.lastname: Oseran
authors.forename: M R
authors.initials: MR
authors.lastname: Myers
mesh_terms: D000328:Adult; D000344:Afferent Pathways / Q000503:physiopathology*; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D004594:Electrophysiology; D005260:Female; D006325:Heart Atria / Q000294:innervation / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000503:physiopathology / Q000628:therapy*; D013617:Tachycardia, Supraventricular / Q000628:therapy*