title: Cisapride in the management of chronic functional dyspepsia: a multicenter, double-blind, placebo-controlled study.
abstract: The effects of cisapride, a nondopaminolytic motility-enhancing agent, were studied in 56 patients with chronic functional dyspepsia; all had symptoms suggestive of delayed gastric emptying. The patients received 4 mg or 8 mg of cisapride or placebo orally three times daily for two successive three-week periods according to a randomized, double-blind, crossover study design. Although there was a high placebo response (55% showed good or excellent results), the global response to treatment was significantly (P = 0.024) in favor of cisapride (75% had good or excellent results). The drug was particularly superior to placebo (P = 0.03) in the improvement of a cluster of symptoms typical of postprandial discomfort, including early satiety and nausea. Side effects were minimal.
authors.affiliation: Medical Center for General Practitioners, Heverlee, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Deruyttere
authors.forename: L
authors.initials: L
authors.lastname: Lepoutre
authors.forename: H
authors.initials: H
authors.lastname: Heylen
authors.forename: H
authors.initials: H
authors.lastname: Samain
authors.forename: H
authors.initials: H
authors.lastname: Pennoit
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D020117:Cisapride; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004415:Dyspepsia / Q000188:drug therapy*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011897:Random Allocation
chemical_list: D010880:Piperidines; D020117:Cisapride