title: [Determination of fibrinogen-fibrin degradation factors in neoplasms].
abstract: Disseminated intravascular coagulation (DIC) and Primary Fibrinolysis (PF) are frequently reported in the literature as occurring in a wide variety of tumours whether subjected to chemotherapy or not and triggering a thrombohemorrhagic mechanism that is often fatal. It was therefore decided to assess the extent of the Fibrinogen-Fibrin Degradation Products (FDP) in a group of cancer patients in order to identify the primary, asymptomatic clinical expressions of these syndromes with a view to ascertaining the possibility of preventing more severe forms. The data confirm the presence of circulating FDP in a small percentage of the patients (26.9%) especially those with solid tumours metastasising to the liver. The involvement of that organ is therefore considered decisive for the onset of DIC and PF.
authors.affiliation: U.S.L. n. 54 - Borgomanero (Novara) Divisione di Medicina Generale.
authors.forename: V
authors.initials: V
authors.lastname: Petrella
authors.forename: G
authors.initials: G
authors.lastname: Massara
authors.forename: F
authors.initials: F
authors.lastname: Parachini
authors.forename: F
authors.initials: F
authors.lastname: Silvera
authors.forename: R
authors.initials: R
authors.lastname: Cantone
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*; D012016:Reference Values
chemical_list: D005338:Fibrin Fibrinogen Degradation Products
vernacular_title: Determinazione dei fattori di degradazione fibrinogeno-fibrina (FDP) in corso di neoplasie.