title: The influence of lung density corrections on treatment planning for primary breast cancer.
abstract: Primary breast cancer is generally treated with opposed radiation beams oriented tangentially with respect to the breast. This technique attempts to minimize the dose to the lung and other normal tissues, while at the same time producing a uniform dose distribution throughout the irradiated breast. Although a part of the lung is always included in the tangential breast fields, the effect of this low density tissue on the dose distribution is rarely taken into account. In the present work, the effect of lung density correction on the dose distribution resulting from tangential breast fields is analyzed. Treatment plans for a series of 34 patients treated for breast cancer have been performed using CT data. To study the effect of density corrections on the tangential field treatment plans for these patients, eight separate treatment plans for each patient have been optimized. For each of four photon energies (60Co, and 4, 6, and 10 MV X rays), treatment plans have been optimized for each patient when density correction is employed, and when unit density is assumed. Four additional dose calculations have been obtained for each patient corresponding to use of the unit density plan, but with density corrections employed in the calculation. The effects that density correction has on the wedge angles used, on the maximum dose ("hot spot") for each of several cross-sectional cuts, on the prescription isodose level which is chosen for each plan, and on homogeneity of the dose distribution over the target volume are all analyzed for the above described plans.
authors.affiliation: Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor 48109.
authors.forename: B A
authors.initials: BA
authors.lastname: Fraass
authors.forename: A S
authors.initials: AS
authors.lastname: Lichter
authors.forename: D L
authors.initials: DL
authors.lastname: McShan
authors.forename: B R
authors.initials: BR
authors.lastname: Yanke
authors.forename: R F
authors.initials: RF
authors.lastname: Diaz
authors.forename: K S
authors.initials: KS
authors.lastname: Yeakel
authors.forename: J
authors.initials: J
authors.lastname: van de Geijn
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008168:Lung / Q000528:radiation effects; D011878:Radiotherapy / Q000379:methods*; D011879:Radiotherapy Dosage; D014057:Tomography, X-Ray Computed