Treatment of alcohol organic mental disorder with piracetam.
1. The paper presents an investigation of the efficiency of piracetam in alcohol organic mental disorder. 2. A double blind placebo controlled study design was used to compare two dosages of the substance (2 x 3g versus 2 x 12g). 3. The cognitive functions of the patients, especially short term memory and concentration, were assessed on the days 0, 7, 14, 28 and 42 using various psychological instruments. 4. An analysis of 39 patients showed an improvement of cognitive functions in all three groups. 5. Patients receiving drug treatment showed earlier responses than patients receiving placebo; differences between the three investigational groups were not statistically significant. 6. The results achieved make the effect of piracetam appear somewhat questionable.
Barnas
C
C
Dpt. of Psychiatry, Innsbruck University Clinics, Austria.
Miller
C
C
Gunther
V
V
Fleischhacker
W W
WW
D000328:Adult; D000367:Age Factors; D000437:Alcoholism / Q000188:drug therapy* / Q000523:psychology; D002986:Clinical Trials as Topic; D003071:Cognition / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010889:Piracetam / Q000008:administration & dosage / Q000627:therapeutic use*; D011760:Pyrrolidinones / Q000627:therapeutic use*; D019966:Substance-Related Disorders / Q000188:drug therapy* / Q000523:psychology
D011760:Pyrrolidinones; D010889:Piracetam