title: Sch 37137, a novel antifungal compound produced by a Micromonospora sp. Taxonomy, fermentation, isolation, structure and biological properties.
abstract: A new antifungal compound, Sch 37137, was isolated from the cultured broth of a Micromonospora sp., SCC 1792. Sch 37137 is structurally related to A 19009, a dipeptide previously discovered from a Streptomyces sp. The compound was weakly active against species of Candida and dermatophytes (mean MICs greater than or equal to 128 micrograms/ml) in Sabouraud dextrose, yeast-nitrogen and modified Eagles minimum essential media; however activity against Candida sp. (mean MICs greater than or equal to 12 micrograms/ml) and dermatophytes (mean MICs greater than or equal to 0.8 microgram/ml) significantly improved in MA medium.
authors.affiliation: Pharmaceutical Research Division, Schering Plough Corporation, Bloomfield, New Jersey 07003.
authors.forename: R
authors.initials: R
authors.lastname: Cooper
authors.forename: A C
authors.initials: AC
authors.lastname: Horan
authors.forename: F
authors.initials: F
authors.lastname: Gentile
authors.forename: V
authors.initials: V
authors.lastname: Gullo
authors.forename: D
authors.initials: D
authors.lastname: Loebenberg
authors.forename: J
authors.initials: J
authors.lastname: Marquez
authors.forename: M
authors.initials: M
authors.lastname: Patel
authors.forename: M S
authors.initials: MS
authors.lastname: Puar
authors.forename: I
authors.initials: I
authors.lastname: Truumees
mesh_terms: D000599:Amino Acids, Diamino / Q000096:biosynthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D008847:Micromonospora / Q000378:metabolism*
chemical_list: D000599:Amino Acids, Diamino; D000935:Antifungal Agents; C055110:N-L-alanyl-3-(((3-(aminocarbonyl)oxiranyl)carbonyl)amino)-L-alanine