title: Enterohepatic circulation of NY-198, a new difluorinated quinolone, in rats.
abstract: Enterohepatic circulation of NY-198 in rats was studied. NY-198 glucuronide in the bile was rapidly hydrolyzed to NY-198 by the intestinal contents. Hydrolyzed and parent NY-198 in the bile were reabsorbed from the intestine. The amount of NY-198 in enterohepatic circulation was 59.8% of that excreted in the bile.
authors.affiliation: College of Medical Technology, Hokkaido University, Sapporo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Saito
authors.forename: O
authors.initials: O
authors.lastname: Nagata
authors.forename: Y
authors.initials: Y
authors.lastname: Takahara
authors.forename: E
authors.initials: E
authors.lastname: Okezaki
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D001646:Bile / Q000378:metabolism; D004764:Enterohepatic Circulation; D024841:Fluoroquinolones; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D011804:Quinolines / Q000493:pharmacokinetics*; D015363:Quinolones; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D011804:Quinolines; D015363:Quinolones; C053091:lomefloxacin