title: Efficacy of sucralfate in the prevention of recurrence of peptic ulcer--double blind multicenter study with cimetidine.
abstract: A double blind, multicenter, six-month maintenance study was performed to assess the efficacy and safety of sucralfate (S), cimetidine (C), and their combination (S + C) in the prevention of peptic ulcer recurrence in a six-month observation period. 127 patients with gastric ulcer (GU) (group S: 39, group S + C: 48, group C:40) and 103 patients with duodenal ulcer (DU) (group S: 35, group S + C: 36, group C:32) were available for statistical analysis. Six to 12 months after healing of GU, the cumulative recurrence prevention rates by Kaplan-Meier method were 89.7----80.3% in group S, 97.6----72.6% in group S + C, 84.5----44.6% in group C. In duodenal ulcer they were 75.9----41.9% in group S, 87.8----47.7% in group S + C, 80.8----40.5% in group C. These results indicate that maintenance therapies of S and S + C are effective and safe for the prevention of gastric ulcer recurrence.
authors.affiliation: Department of Internal Medicine I, Yamaguchi University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takemoto
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: K
authors.initials: K
authors.lastname: Okita
authors.forename: K
authors.initials: K
authors.lastname: Tsuneoka
authors.forename: S
authors.initials: S
authors.lastname: Ohshiba
authors.forename: M
authors.initials: M
authors.lastname: Namiki
authors.forename: S
authors.initials: S
authors.lastname: Fukuchi
authors.forename: T
authors.initials: T
authors.lastname: Miyake
authors.forename: H
authors.initials: H
authors.lastname: Fukutomi
authors.forename: Y
authors.initials: Y
authors.lastname: Okazaki
mesh_terms: D000328:Adult; D002927:Cimetidine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D010437:Peptic Ulcer / Q000517:prevention & control*; D011897:Random Allocation; D013392:Sucralfate / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D013392:Sucralfate; D002927:Cimetidine