title: Effect of animal sex on experimental ciclosporin nephrotoxicity.
abstract: Experimental ciclosporin (CSA) nephrotoxicity is reported to be more severe in male versus female rodents. To investigate these sex differences further, groups of male and female Sprague-Dawley rats were pair fed and given either CSA 50 mg/kg or olive oil vehicle by gavage daily for 5 days. Both groups of treated animals showed azotemia and depression of CIn but there were no sex differences. CSA levels were 5,820 ng/ml in females and 6,480 ng/ml in males (p = NS). Although CSA did not produce enzymuria in either sex, females showed more extensive proximal tubular cell vacuolization.
  
  
  CONCLUSIONS
  Female Sprague-Dawley rats are equally as susceptible to CSA nephrotoxicity as males. Strain differences or experimental design may account for apparently conflicting results in the literature.
authors.affiliation: Department of Medicine, Oregon Health Sciences University, Portland.
authors.forename: N
authors.initials: N
authors.lastname: Ross
authors.forename: J
authors.initials: J
authors.lastname: English
authors.forename: W M
authors.initials: WM
authors.lastname: Bennett
mesh_terms: D000818:Animals; D003524:Cyclosporins / Q000633:toxicity*; D005260:Female; D007444:Inulin; D007672:Kidney Cortex / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
chemical_list: D003524:Cyclosporins; D007444:Inulin