title: Histiocytosis X with scoliosis and osteolysis.
abstract: Histiocytosis X can exhibit a variety of musculoskeletal manifestations. Nonetheless, this case exhibits two striking features. Severe progressive scoliosis and massive osteolysis of both femoral shafts occurred in conjunction with the Hand-Schüller-Christian form of histiocytosis X. The scoliosis was treated successfully by posterior fusion and instrumentation. The clinical features of histiocytosis X are reviewed. Speculation as to the etiology of these features is presented.
authors.affiliation: Department of Orthopaedics, University of Iowa Hospitals, Iowa City 52242.
authors.forename: R R
authors.initials: RR
authors.lastname: Wroble
authors.forename: S L
authors.initials: SL
authors.lastname: Weinstein
mesh_terms: D001862:Bone Resorption / Q000000981:diagnostic imaging; D002675:Child, Preschool; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D009984:Orthopedic Fixation Devices; D010014:Osteolysis / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D012600:Scoliosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D013123:Spinal Fusion; D013131:Spine / Q000601:surgery