Administration of radiation or cyclophosphamide versus alternated radiation and cyclophosphamide treatment of primary tumor and pulmonary metastases.
The experimental tumor 3924A in ACI rats metastasizes to the lungs, but this is rarely apparent unless the life span of the animal is increased by treatment of the tumor. Pulmonary metastases were prevalent among animals given radiation daily or in multiple fractions per day over periods of 3-4 weeks at total doses ranging from 3,000 to 11,250 rad. Multiple doses of cyclophosphamide, each at the level that was lethal to 10% of the animals, did not cure the primary tumor but appeared to delay the appearance of metastases. Treatment schedules that alternated the delivery of multiple 250-rad fractions of radiation during 2-day periods with cyclophosphamide at a dose of 150 mg/kg for a total of three courses were effective in curing the primary tumor and eliminating pulmonary metastases.
Looney
W B
WB
Division of Radiobiology and Biophysics, University of Virginia Hospital, Charlottesville 22908.
Hopkins
H A
HA
D000818:Animals; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy; D009374:Neoplasms, Experimental / Q000628:therapy*; D011879:Radiotherapy Dosage; D051381:Rats; D011919:Rats, Inbred Strains
D003520:Cyclophosphamide