Hemodynamic and cardiac metabolic changes during nicardipine-induced myocardial ischemia.
After 10 mg nicardipine IV a patient with stable angina developed chest pain and ST-segment depression accompanied by excessive tachycardia, low arterial blood pressure, and initially decreased coronary sinus blood flow. Measurements of arterial concentrations and cardiac exchanges of lactate, glucose, free fatty acids, glutamate, and alanine showed alterations indicative of severe ischemia.
Thomassen
A R
AR
Aarhus Kommunehospital, Department of Cardiology, Denmark.
Bagger
J P
JP
Nielsen
T T
TT
D000787:Angina Pectoris / Q000175:diagnosis; D003327:Coronary Disease / Q000139:chemically induced*; D004562:Electrocardiography; D005080:Exercise Test; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D009529:Nicardipine / Q000009:adverse effects*
D009529:Nicardipine