The role of the superior cervical ganglia in the nocturnal rise of pineal type-II thyroxine 5'-deiodinase activity.
Superior cervical ganglionectomy (SCGx) abolished the nocturnal rise in pineal type-II thyroxine 5'-deiodinase (5'-D) activity in both euthyroid and hypothyroid rats. Isoproterenol induced at least as great a rise in diurnal pineal 5'-D in SCGx as in intact rats. These data suggest that beta-adrenergic stimulation through the superior cervical ganglia is essential for the nocturnal rise in pineal 5'-D activity.
Murakami
M
M
Department of Medicine, Oregon Health Sciences University, Portland 97201.
Greer
M A
MA
Hjulstad
S
S
Greer
S E
SE
Tanaka
K
K
D000818:Animals; D002940:Circadian Rhythm; D005727:Ganglia, Spinal / Q000502:physiology*; D007453:Iodide Peroxidase / Q000378:metabolism / Q000502:physiology*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D010870:Pineal Gland / Q000187:drug effects / Q000201:enzymology* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000502:physiology
D007453:Iodide Peroxidase; D007545:Isoproterenol