[Preliminary study on the antimutagenesis of vegetables and fruits].
Possible antimutation of 108 preparations of 91 kinds of vegetables and fruits on Salmonella typhimurium TA98 and TA100 mutants was tested. 4-nitroquinoline-N-oxide (4 NQO), N-methyl-N-nitro-N-nitrosoguanidine (MNNG), aflatoxin B1 (AFB1) and benzo (a) pyrene (BaP) were used as mutagens. The results showed that 67 (62%) preparations had antimutagenic action in vitro to different degrees. 9.6% of all preparations showed inhibition action on 4 NQO in TA100 mutant and 12.3%, in TA98, 5% on MNNG in TA100, 38% on AFB1 in TA100 and 45.1% in TA98, 28.9% on BaP in TA100. This experiment provides a scientific basis to the study of food resources as prevention of carcinogenesis.
Luo
H Z
HZ
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
Cheng
S J
SJ
Jang
Y Z
YZ
Han
N J
NJ
Li
X Q
XQ
Yie
S Y
SY
Liang
J L
JL
D000818:Animals; D005638:Fruit; D008297:Male; D009152:Mutagenicity Tests / Q000379:methods; D009154:Mutation; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics; D014675:Vegetables