title: Copper deficiency and tissue glutathione concentration in the rat.
abstract: Copper deficiency in rats increased renal vein and arterial (heart) plasma GSH concentration by approximately 50%. There was no change in plasma GSSG concentration. Renal vein plasma GSSG/GSH ratio was decreased in copper deficiency, which is consistent with previous reports showing a copper-dependent thiol oxidase activity in the renal basement membrane. No change occurred in arterial plasma GSSG/GSH ratio. Hepatic GSH concentrations were also elevated by 50% in copper deficiency, GSSG concentrations were unaffected, but GSSG/GSH ratio was depressed. Renal and cardiac tissue GSH and GSSG were unaffected by copper deficiency. The decreased SOD activity and GSH-Px activity observed in copper deficiency may contribute to increased hepatic and plasma GSH concentrations.
authors.affiliation: Rowett Research Institute, Bucksburn, Aberdeen, Scotland, United Kingdom.
authors.forename: K G
authors.initials: KG
authors.lastname: Allen
authors.forename: J R
authors.initials: JR
authors.lastname: Arthur
authors.forename: P C
authors.initials: PC
authors.lastname: Morrice
authors.forename: F
authors.initials: F
authors.lastname: Nicol
authors.forename: C F
authors.initials: CF
authors.lastname: Mills
mesh_terms: D000818:Animals; D001158:Arteries; D003300:Copper / Q000172:deficiency*; D005978:Glutathione / Q000097:blood / Q000378:metabolism*; D006352:Heart Ventricles; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D012082:Renal Veins
chemical_list: D003300:Copper; D005978:Glutathione