title: Measurement of tidal volume during high frequency ventilation by impedance plethysmography.
abstract: Electrical impedance plethysmography was evaluated in lambs as a method of measuring tidal volume (VT). Over tidal volumes ranging from 15 to 414% of estimated dead space, and frequencies of 300 to 1000 breaths/min, correlation between VT measured by the impedance technique and VT measured by whole-body plethysmography was 0.98. Above 600 breaths/min, the correlation between the two methods was 0.94. Independent calibration of the impedance technique using a pneumotachograph at conventional rates of ventilation yielded absolute values of VT which closely corresponded to values obtained with the whole-body plethysmograph (slope = 1.05, intercept = 1.4 ml, r = 0.99). These results support the potential utility of impedance plethysmography in clinical applications of high frequency ventilation.
authors.affiliation: Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232.
authors.forename: K L
authors.initials: KL
authors.lastname: Sandberg
authors.forename: D P
authors.initials: DP
authors.lastname: Lindstrom
authors.forename: E D
authors.initials: ED
authors.lastname: Krueger
authors.forename: H
authors.initials: H
authors.lastname: Sundell
authors.forename: R B
authors.initials: RB
authors.lastname: Cotton
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D006612:High-Frequency Ventilation; D010992:Plethysmography, Impedance; D010993:Plethysmography, Whole Body; D012756:Sheep; D013990:Tidal Volume