Learning and memory impairment with benzhexol.
A double-blind trial to determine the effects of a single dose of 2 mg benzhexol on cognitive functioning was undertaken using normal volunteers. Ninety minutes after the drug or placebo was taken, subjects completed a battery of psychological tests designed to measure learning, memory and motor skills. Benzhexol ingestion was associated with significant impairment of short-term memory and slowing of the rate of new learning.
Galletly
C A
CA
Hillcrest Hospital, Adelaide, SA.
Field
C D
CD
D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D008570:Memory, Short-Term / Q000187:drug effects; D009483:Neuropsychological Tests; D014282:Trihexyphenidyl / Q000494:pharmacology*
D014282:Trihexyphenidyl