Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell.
12-O-Tetradecanoylphorbol-13-acetate (TPA), a highly active representative of the tumor-promoting phorbol esters, induces a rapid terminal differentiation of a human colon cancer cell line. Bryostatin 1, a macrocyclic lactone, completely counteracts this effect of TPA and promotes continued replication. The observed responses provide a system for identifying cellular processes which are involved in the induced terminal differentiation of human colon cancer cells.
McBain
J A
JA
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
Pettit
G R
GR
Mueller
G C
GC
D054713:Bryostatins; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003110:Colonic Neoplasms / Q000473:pathology*; D004261:DNA Replication / Q000187:drug effects; D006801:Humans; D007783:Lactones / Q000494:pharmacology*; D018942:Macrolides; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D054713:Bryostatins; D007783:Lactones; D018942:Macrolides; C046785:bryostatin 1; D013755:Tetradecanoylphorbol Acetate