title: Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole.
abstract: The development of a pharyngocutaneous fistulae is a major complication after total laryngectomy. In Denmark radiotherapy is the primary treatment for all laryngeal carcinomas. Based on the experience with conventional daily irradiation, a split-course radiation schedule was introduced in 1978. The charts of 106 consecutive patients laryngectomized for recurrence in the years 1975 to 1984 were examined. Thirty-four patients developed a fistula. An evaluation of the different radiotherapy schedules used during this period allowed a dose-response curve to be constructed. It showed a pronounced increase of fistulae with high doses of radiotherapy. Split-course radiotherapy caused a rise in late complications and did not improve tumor control. Large field sizes increased the number of fistulae. High-dose fractions showed a surprisingly high incidence of late complications. Prophylactic metronidazole (introduced in 1980) resulted in a highly significant decrease in the frequency of postoperative fistulae. Patients in whom fistula formed were hospitalized for an average of 54 days, patients without, for 22 days.
authors.affiliation: ENT Department, Aarhus University Hospital, Denmark.
authors.forename: L V
authors.initials: LV
authors.lastname: Johansen
authors.forename: J
authors.initials: J
authors.lastname: Overgaard
authors.forename: O
authors.initials: O
authors.lastname: Elbrønd
mesh_terms: D005402:Fistula / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D007825:Laryngectomy / Q000009:adverse effects*; D008795:Metronidazole / Q000627:therapeutic use*; D010608:Pharyngeal Diseases / Q000209:etiology* / Q000517:prevention & control; D011832:Radiation Injuries / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects* / Q000379:methods; D011879:Radiotherapy Dosage; D012871:Skin Diseases / Q000209:etiology* / Q000517:prevention & control
chemical_list: D008795:Metronidazole