Intravenous platelet activating factor does not affect lung epithelial permeability.
Administration of platelet activating factor has been shown to produce lung edema in several species including the rabbit. To determine if platelet activating factor increases lung alveolar epithelial permeability, we studied the effect of intravenous platelet activating factor administration on clearance of 99mTc-DTPA from the lung of the rabbit. Intravenous platelet activating factor produced marked hemodynamic and cellular responses but did not increase the clearance of 99mTc-DTPA from lung to blood. We conclude that although platelet activating factor can induce lung edema in the rabbit, it does not produce an acute increase in alveolar epithelial permeability.
Bloom
J W
JW
Division of Respiratory Sciences, University of Arizona College of Medicine, Tucson 85724.
Quan
S F
SF
Halonen
M
M
Witten
M L
ML
Lemen
R J
RJ
Patton
D D
DD
D000818:Animals; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid; D010539:Permeability; D010972:Platelet Activating Factor / Q000008:administration & dosage*; D011652:Pulmonary Circulation / Q000187:drug effects; D011817:Rabbits; D016284:Technetium Tc 99m Pentetate
D009942:Organometallic Compounds; D010972:Platelet Activating Factor; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate