Stem cell number versus the fraction synthesizing DNA.
It has been widely held that the fraction of spleen colony-forming units (CFU-S) in DNA synthesis is inversely correlated with CFU-S numbers. In 750 measurements the expected negative slope of the linear regression of CFU-S in S-phase on CFU-S was found to be significant only when the measurements from irradiated mice were pooled. In contrast, a significant positive correlation was observed when the measurements from normal controls were pooled. A hypothesis is offered to account for the variable relationship between CFU-S and CFU-S in S. The hypothesis fully recognizes the crucial role of both parameters in normal and regenerative hemopoiesis.
Necas
E
E
Department of Pathophysiology, Faculty of General Medicine, Charles University, Prague, Czechoslovakia.
Znojil
V
V
Vácha
J
J
D000818:Animals; D002452:Cell Count; D003114:Colony-Forming Units Assay; D004247:DNA / Q000096:biosynthesis*; D051379:Mice; D012106:Research; D013154:Spleen / Q000166:cytology*; D013223:Statistics as Topic
D004247:DNA