Effect of low doses of whole body irradiation on spontaneous lung metastasis of NFSA2ALM1 mouse tumors.
The effect of low-dose (10-50 cGy) irradiation, delivered as single or fractionated doses, on metastatic development was investigated using NFSA2ALM1 fibrosarcoma and the C3H/HeNrs mouse. Spontaneous lung metastases from tumors transplanted into the leg were suppressed in those mice irradiated with low doses of radiation 12 days after tumor cell inoculation. Abbreviations used: LCFE = lung colony forming efficiency through i.v. injection of tumor cells; SLME = spontaneous lung metastasis efficiency from leg tumors; TD50 = cell number which produces tumors in 50% of inoculated sites; WBI = Whole body irradiation.
Suzuki
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N
Department of Radiation Oncology, Faculty of Medicine, University of Tokyo, Japan.
Mizukoshi
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T
D000818:Animals; D005354:Fibrosarcoma / Q000532:radiotherapy* / Q000556:secondary; D008175:Lung Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011879:Radiotherapy Dosage; D014916:Whole-Body Irradiation