title: Heterogeneity of biotransformation of fluoranthene in perifused liver cells.
abstract: Pathways of biotransformation of the carcinogenic polycyclic hydrocarbon fluoranthene in individual isolated perifused liver cells were delineated using noninvasive microfluorescence spectroscopic techniques. An example of heterogeneity of coupling between phase I and phase II enzymes detected in a population of beta-naphthoflavone-induced rat liver cells demonstrates the usefulness of the experimental model of perifused liver cells.
authors.affiliation: Max-Planck-Institut for Biophysical Chemistry, Göttingen, Federal Republic of Germany.
authors.forename: A
authors.initials: A
authors.lastname: Stier
authors.forename: A
authors.initials: A
authors.lastname: Schlenker
authors.forename: J
authors.initials: J
authors.lastname: Sidhu
authors.forename: W
authors.initials: W
authors.lastname: Kühnle
authors.forename: S A
authors.initials: SA
authors.lastname: Finch
mesh_terms: D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D005449:Fluorenes / Q000378:metabolism* / Q000493:pharmacokinetics; D005453:Fluorescence; D008099:Liver / Q000378:metabolism*; D008297:Male; D010636:Phenols / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005449:Fluorenes; D010636:Phenols; C007738:fluoranthene; D003577:Cytochrome P-450 Enzyme System