Effect of androgens on phalloidin-induced liver toxicity in mice.
A single i.p. dose of phalloidin, 0.75 or 1 mg/kg body weight, induced peliosis hepatis-like lesion (PHLL) at 3 h after injection to mice. Pretreatment with various doses of testosterone propionate for 7 days enhanced phalloidin-induced PHLL. Other anabolic steroids, methyltestosterone, methandriol. fluoxymesterone and oxymetholone had no effect.
Muraoka
Y
Y
Shionogi Research Laboratories, Kanzakigawa Laboratory, Osaka, Japan.
Watanabe
H
H
Kometani
M
M
Hasegawa
T
T
D000728:Androgens / Q000633:toxicity*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D004357:Drug Synergism; D005260:Female; D008099:Liver / Q000187:drug effects*; D051379:Mice; D008809:Mice, Inbred C3H; D009842:Oligopeptides / Q000633:toxicity*; D010590:Phalloidine / Q000633:toxicity*; D013739:Testosterone / Q000633:toxicity
D000728:Androgens; D009842:Oligopeptides; D010590:Phalloidine; D013739:Testosterone