title: Influence of single and double immunomagnetic depletion on the hemopoietic capacity of marrow in patients with advanced neuroblastoma submitted to autologous bone marrow transplantation.
abstract: Eighteen marrows from 16 patients with advanced neuroblastoma were submitted to a single or double immunomagnetic depletion procedure to purge them of tumor cells. Analysis of results showed that the CFU-GM recoveries were 59% +/- 16 (SE) and 33% +/- 16 after one or two cycles of incubation with microspheres. This led to yields of 7.8 x 10(4) and 4.1 x 10(4) CFU-GM available per kg body weight, respectively. Successful engraftment was demonstrated in all evaluable patients. However, some patients had delayed hematologic recoveries, particularly for platelets.
authors.affiliation: INSERM U 76, CNTS Institut, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Lopez
authors.forename: J M
authors.initials: JM
authors.lastname: Zucker
authors.forename: R
authors.initials: R
authors.lastname: Urresola
authors.forename: L
authors.initials: L
authors.lastname: Douay
authors.forename: E
authors.initials: E
authors.lastname: Quintana
authors.forename: J
authors.initials: J
authors.lastname: Kemshead
authors.forename: N C
authors.initials: NC
authors.lastname: Gorin
authors.forename: J R
authors.initials: JR
authors.lastname: Vilcoq
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002469:Cell Separation / Q000379:methods; D003114:Colony-Forming Units Assay; D006098:Granulocytes; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D007158:Immunologic Techniques; D007963:Leukocytes, Mononuclear; D008264:Macrophages; D008280:Magnetics; D009447:Neuroblastoma / Q000473:pathology / Q000628:therapy*; D014182:Transplantation, Autologous
chemical_list: D000911:Antibodies, Monoclonal