title: [Combination use of lentinan with X-ray therapy in a mouse experimental tumor system (Part I). Basic studies].
abstract: Apparent reduction of leukocyte counts was observed in mice irradiated with 1,500 approximately 3,000 rads of X-ray on the left hind leg. This reduction of leukocyte counts was completely protected by the pre-treatment with lentinan before X-ray irradiation. Suppressive effect of X-ray on the antitumor function of lentinan seems to be weak. When treatment with X-ray irradiation and lentinan was applied for mice bearing solid type sarcoma 180, additive effect was obtained by the combination of lentinan before or after X-ray irradiation.
authors.affiliation: Life Science Laboratory, Central Research Laboratories, Ajinomoto Co. Inc.
authors.forename: T
authors.initials: T
authors.lastname: Shiio
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuchiya
authors.forename: K
authors.initials: K
authors.lastname: Ohishi
authors.forename: T
authors.initials: T
authors.lastname: Yoshihama
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy; D005260:Female; D007912:Lentinan / Q000008:administration & dosage*; D007970:Leukopenia / Q000517:prevention & control*; D051379:Mice; D008813:Mice, Inbred ICR; D011134:Polysaccharides / Q000008:administration & dosage*; D011879:Radiotherapy Dosage; D012074:Remission Induction; D012510:Sarcoma 180 / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D011134:Polysaccharides; D007912:Lentinan