Beta-substituted phenethylamines as high-affinity mechanism-based inhibitors of dopamine beta-hydroxylase.
Kruse
L I
LI
Department of Medicinal Chemistry, Smith Kline & French Laboratories, Swedeland, Pennsylvania 19406.
Kaiser
C
C
DeWolf
W E
WE
Chambers
P A
PA
Goodhart
P J
PJ
Ezekiel
M
M
Ohlstein
E H
EH
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002417:Cattle; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors*; D006973:Hypertension / Q000201:enzymology; D007700:Kinetics; D010627:Phenethylamines / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D013329:Structure-Activity Relationship; D013997:Time Factors
D010627:Phenethylamines; D004299:Dopamine beta-Hydroxylase