Familial double testicular tumors: identical chromosome changes in seminoma and embryonal carcinoma of the same testis.
An identical abnormal chromosome, i(12p), and a marker chromosome of unknown origin were seen in 2 tumors of different histology (seminoma and embryonal carcinoma) in the same testis. A younger brother of the patient also had undergone orchiectomy for 2 seminomas in the left testis 2 years previously. These findings are discussed in relation to the possible cellular background of testicular tumors and their genetic parameters.
Haddad
F S
FS
Veterans Administration Hospital, Phoenix, Arizona.
Sorini
P M
PM
Somsin
A A
AA
Nathan
M H
MH
Dobbs
R M
RM
Berger
C S
CS
Sandberg
A A
AA
D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002881:Chromosomes, Human, Pair 12; D004407:Dysgerminoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology; D013724:Teratoma / Q000235:genetics* / Q000473:pathology; D013736:Testicular Neoplasms / Q000235:genetics* / Q000473:pathology; D013737:Testis / Q000473:pathology