title: Comparison of aqueous grain dusts, cotton dusts, and mold extracts by crossed immunoelectrophoretic techniques.
abstract: To evaluate the possibility that an immune response is involved in the pathogenesis of grain dust or cotton dust induced respiratory disease, 1 grain dust extract (A) was compared with 4 similar grain dust extracts, a cotton dust extract, and a mixture of fungal preparations, using crossed immunoelectrophoretic techniques and rabbit anti-A sera. All extracts demonstrated a significant number of shared antigenic determinants. These data suggest that grain and cotton dust may induce disease via a common pathogenic mechanism and putative agent(s).
authors.affiliation: Department of Medicine, Tulane Medical Center, New Orleans, La.
authors.forename: C E
authors.initials: CE
authors.lastname: O'Neil
authors.forename: B T
authors.initials: BT
authors.lastname: Butcher
authors.forename: H
authors.initials: H
authors.lastname: Chan
authors.forename: M
authors.initials: M
authors.lastname: Chan-Yeung
mesh_terms: D000485:Allergens / Q000032:analysis*; D000818:Animals; D000946:Antigens, Fungal / Q000032:analysis; D004391:Dust; D002523:Edible Grain / Q000276:immunology; D003368:Gossypium / Q000276:immunology; D007122:Immunoelectrophoresis / Q000379:methods; D007123:Immunoelectrophoresis, Two-Dimensional / Q000379:methods; D011817:Rabbits
chemical_list: D000485:Allergens; D000946:Antigens, Fungal; D004391:Dust