Prolonged fever as a presenting symptom in adrenal tumors.
Four patients with adrenal tumors in whom prolonged fever was the foremost symptom are presented. Two of the patients had nonfunctional adrenocortical carcinoma, one had a pheochromocytoma without adrenergic hyperactivity, and in the fourth, an aldosteronoma was found. Only in 1 case was the tumor (pheochromocytoma) resectable and this patient became afebrile post surgery. A review of the literature revealed that fever is encountered in 6-10% of cases with adrenal tumors, sometimes as the first manifestation of disease. However, a survey of the large series of fever of unknown origin revealed no mention of adrenal tumors in that group of solid tumors which many cause prolonged fever.
Klausner
J M
JM
Rokach (Hadassah) Hospital, Tel-Aviv Medical Center, Israel.
Nakash
R
R
Inbar
M
M
Gutman
M
M
Lelcuk
S
S
Rozin
R R
RR
D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000503:physiopathology; D000368:Aged; D005260:Female; D005334:Fever / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged