New aureolic acid antibiotics. I. Screening, isolation, characterization and biological properties.
A new antibiotic complex was isolated from the fermentation broth of Streptomyces aburaviensis PA-39856. The individual factors, demethylolivomycins A, B and demethylchromomycins A2, A3 were separated and purified by preparative HLC. These antibiotics possess high activities against Gram-positive bacteria and P388 leukemia in mice.
Koenuma
M
M
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Uchida
N
N
Yamaguchi
K
K
Kawamura
Y
Y
Matsumoto
K
K
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D013302:Streptomyces / Q000378:metabolism
D000903:Antibiotics, Antineoplastic