title: Pharmacokinetics of doxycycline in dogs.
abstract: Six adult dogs were given doxycycline hyclate at a dosage of 5 mg/kg of body weight intravenously so that pharmacokinetic parameters could be evaluated. Serum doxycycline concentrations were determined over a 48 h period using a modified agar well bioassay. Compartmental pharmacokinetic evaluation of the serum concentration time data indicated that doxycycline has a half-life of 10.36 h, a body clearance of 1.68 +/- 0.44 mL/min/kg, and a volume of distribution at steady state of 1.468 +/- 0.237 L/kg. Doxycycline pharmacokinetics are favorable for therapeutic use in the dog.
authors.affiliation: Department of Physiology, College of Veterinary Medicine, Auburn University, Alabama 36849.
authors.forename: R C
authors.initials: RC
authors.lastname: Wilson
authors.forename: D T
authors.initials: DT
authors.lastname: Kemp
authors.forename: J V
authors.initials: JV
authors.lastname: Kitzman
authors.forename: D D
authors.initials: DD
authors.lastname: Goetsch
mesh_terms: D000818:Animals; D004285:Dogs / Q000378:metabolism*; D004318:Doxycycline / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D008838:Microcomputers; D012984:Software
chemical_list: D004318:Doxycycline