From 2 Gy to 1 Gy per fraction: sparing effect in rat spinal cord?
Recently published results, from this group, on rat cervical spinal cord, a late responding tissue, indicated no further sparing with lowering the fraction size from 2 to 1.8, 1.5, and 1.3 Gy. In the present experiments a small but probably significant rise in tolerance is suggested, when the dose per fraction was decreased from 2 Gy down to 1 Gy. This rise would however still be much less than what is predicted by the linear quadratic model, based on the experimental data obtained with fraction sizes larger than 2 Gy.
van der Schueren
E
E
Department of Experimental Radiotherapy, University Hospital St.-Rafaël, Leuven, Belgium.
Landuyt
W
W
Ang
K K
KK
van der Kogel
A J
AJ
D000818:Animals; D011829:Radiation Dosage; D011836:Radiation Tolerance; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000528:radiation effects*