title: Agarose encapsulation of islets of Langerhans: reduced toxicity in vitro.
abstract: The physical and chemical properties of agarose have been exploited for encapsulation of islets of Langerhans. Formation of microcapsules by extrusion of a hydrophilic polymer (agarose) into a hydrophobic solution created an interface to which an immunoprotective membrane could be polymerized. The substances and procedure used were devoid of cellular toxicity. Islet function in vitro was found to be normal.
authors.affiliation: INSERM U. 306, CEEMASI, Bordeaux, France.
authors.forename: H
authors.initials: H
authors.lastname: Gin
authors.forename: B
authors.initials: B
authors.lastname: Dupuy
authors.forename: C
authors.initials: C
authors.lastname: Baquey
authors.forename: D
authors.initials: D
authors.lastname: Ducassou
authors.forename: J
authors.initials: J
authors.lastname: Aubertin
mesh_terms: D000818:Animals; D004339:Drug Compounding; D007515:Islets of Langerhans / Q000502:physiology*; D011108:Polymers; D051381:Rats; D012685:Sepharose / Q000494:pharmacology*
chemical_list: D011108:Polymers; D012685:Sepharose