Heat-induced expression of albumin during early stages of rat embryo development.
An examination of heat-induced expression of proteins in tissues from adult and embryonic liver in rats shows that albumin, which is constitutively expressed in adult liver and is not synthesized in embryos before 16 days of gestation, appears in liver cells at earlier stages of development upon heat shock. On the basis of available evidence for the expression of heat shock proteins at distinct stages of development and on the basis of our findings, it may be argued that there could be common molecular events taking place during development and as a result of heat shock. We suggest also that one of the consequences of heat shock could be an internal change of pH within the cell which, in turn, might trigger alterations in gene expression.
Srinivas
U K
UK
Centre for Cellular & Molecular Biology, Hyderabad, India.
Revathi
C J
CJ
Das
M R
MR
D000418:Albumins / Q000235:genetics*; D000818:Animals; D004247:DNA / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D005786:Gene Expression Regulation; D005865:Gestational Age; D006358:Hot Temperature; D007118:Immunoassay; D007163:Immunosorbent Techniques; D008099:Liver / Q000196:embryology* / Q000378:metabolism; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D014158:Transcription, Genetic
D000418:Albumins; D012333:RNA, Messenger; D004247:DNA