Reduced excretion of vasodilator prostaglandins in preeclampsia.
The role of prostaglandin (PG) system in preeclampsia (pre-E) was investigated. Urinary excretion of PGE2,6-keto PGF1 alpha,2,3 dinor 6-keto PGF1 alpha, TxB2 and 2,3-dinor-TxB2 and kallikrein were determined in 10 normotensive pregnant women and 14 with pre-E. 6-keto PGF1 alpha and 2,3-dinor 6-keto PGF1 alpha (the main renal and extrarenal metabolites of vasodilator PGI2) and PGE2 excretion was lower in pre-E. TxB2 metabolites in urine were similar in the two groups of women. Our data are consistent with the hypothesis of an imbalance between vasodilator and vasoconstrictor PGs in pre-E.
Minuz
P
P
Clinica Medica dell'Università, Policlinico di Borgo Roma, Verona, Italy.
Covi
G
G
Corsato
M
M
Probitzer
P
P
Spiazzi
L
L
Paluani
F
F
Degan
M
M
Lechi
C
C
Lechi
A
A
D015121:6-Ketoprostaglandin F1 alpha / Q000031:analogs & derivatives / Q000652:urine; D000328:Adult; D015232:Dinoprostone; D011464:Epoprostenol / Q000378:metabolism; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism; D011225:Pre-Eclampsia / Q000378:metabolism / Q000652:urine*; D011247:Pregnancy; D011453:Prostaglandins / Q000652:urine*; D011458:Prostaglandins E / Q000652:urine; D013928:Thromboxane A2 / Q000378:metabolism; D013929:Thromboxane B2 / Q000652:urine; D014665:Vasodilator Agents / Q000652:urine*
D011453:Prostaglandins; D011458:Prostaglandins E; D014665:Vasodilator Agents; D013929:Thromboxane B2; D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha; C028290:2,3-dinor-6-ketoprostaglandin F1alpha; D011464:Epoprostenol; D015232:Dinoprostone