title: Bone marrow transplantation for secondary (therapy-related) acute non-lymphoblastic leukaemia: report of a case associated with adoptive beta-thalassaemia.
abstract: A female patient with therapy-related acute non-lymphoblastic leukaemia occurring after intensive combined modality treatment for IIIB Hodgkin's disease was transplanted from her HLA-identical brother. No attempt was made to induce a remission and the transplant was performed with standard chemoradiotherapeutic conditioning. Three years after the transplant the patient is alive in complete remission with a 46,XY karyotype. The donor has a mild, heterozygous beta-thalassaemia ('thalassaemia minima'). The recipient has much more pronounced thalassaemic features, similar to so-called thalassaemia intermedia, with peripheral blood smears indistinguishable from thalassaemia major. The erythrocytic alterations are undoubtedly due to the splenectomy which was performed during a staging procedure, but the marked difference between donor and recipient haemoglobin values cannot be attributed solely to the asplenic state.
authors.affiliation: Divisione di Ematologia, Ospedale S. Martino, Genova, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Marmont
authors.forename: M T
authors.initials: MT
authors.lastname: van Lint
authors.forename: A
authors.initials: A
authors.lastname: Bacigalupo
authors.forename: G V
authors.initials: GV
authors.lastname: Sciaratta
authors.forename: G
authors.initials: G
authors.lastname: Ivaldi
mesh_terms: D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy / Q000009:adverse effects; D005260:Female; D005914:Globins / Q000235:genetics; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000209:etiology / Q000628:therapy*; D013789:Thalassemia / Q000150:complications*; D014019:Tissue Donors
chemical_list: D005914:Globins