Neonatal myasthenia gravis: a new clinical and immunologic appraisal on 30 cases.
Anti-acetylcholine receptor (AChR) antibody titers, toxin binding blocking antibody, functional activity of serum on rat myotube cultures, IgG subclasses, and clinical data were studied in relation to the onset of neonatal myasthenia gravis (NMG) in 30 children of myasthenic mothers. Fourteen had NMG, including 4 atypical cases. Anti-AChR antibody titer was the best indication of NMG onset. NMG in a previous baby was also predictive. Pattern of IgG subclasses, presence of toxin-binding blocking antibodies, and serum functional activity were less predictive, but cast light on the mechanism of anti-AChR antibody pathogenicity.
Morel
E
E
INSERM U25-CNRS UA 122, Hôpital Necker, Paris, France.
Eymard
B
B
Vernet-der Garabedian
B
B
Pannier
C
C
Dulac
O
O
Bach
J F
JF
D000818:Animals; D000906:Antibodies / Q000032:analysis / Q000502:physiology; D002038:Bungarotoxins / Q000378:metabolism; D005078:Exchange Transfusion, Whole Blood; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007132:Immunoglobulin Isotypes / Q000032:analysis; D007231:Infant, Newborn; D009157:Myasthenia Gravis / Q000151:congenital* / Q000276:immunology / Q000628:therapy; D051381:Rats; D011950:Receptors, Cholinergic / Q000276:immunology
D000906:Antibodies; D002038:Bungarotoxins; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D011950:Receptors, Cholinergic