Oestrogen and progesterone receptors in lentigo maligna.
We have measured oestrogen and progesterone binding in specimens of histopathologically confirmed lentigo maligna (LM) lesions excised from five elderly white men, using a dextran-coated charcoal method. Oestrogen binding was observed in four of the five specimens, and progesterone binding in all five. Marginal normal skin showed only non-specific binding for oestrogen and progesterone. The presence of steroid hormone receptors in LM suggests the possibility that hormone responsiveness may be relevant in the transformation of a lentigo maligna into malignant melanoma.
Sawaya
M E
ME
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Florida 33101.
Garland
L D
LD
Rothe
M J
MJ
Honig
L S
LS
Hsia
S L
SL
D000368:Aged; D006801:Humans; D007911:Lentigo / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D012867:Skin / Q000032:analysis
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone