title: Mutagenicity studies on thymomodulin.
abstract: Thymomodulin (Leucotrofina), an orally administrable thymic derivative endowed with interesting immunomodulating and myelomodulating properties, was tested for mutagenicity by means of the following in vitro and in vivo tests: mutagenesis on S. typhimurium with and without metabolic activation system (S-9), gene conversion on S. cerevisiae D 7 with and without metabolic activation, urinary assay in the mouse with and without metabolic activation, urinary assay in the mouse with S. cerevisiae D 7, host mediated assay in the mouse with S. cerevisiae and DNA repair test with and without metabolic activation. On the basis of the results obtained thymomodulin proved to be free of mutagenic activity.
authors.affiliation: Institute of Pharmacology, University of Bologna, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cantelli-Forti
authors.forename: P
authors.initials: P
authors.lastname: Hrelia
authors.forename: M
authors.initials: M
authors.lastname: Scotti
authors.forename: V
authors.initials: V
authors.lastname: Scornavacche
authors.forename: M
authors.initials: M
authors.lastname: Prada
mesh_terms: D000818:Animals; D001711:Biotransformation; D004260:DNA Repair; D006801:Humans; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013949:Thymus Extracts / Q000378:metabolism / Q000633:toxicity* / Q000652:urine
chemical_list: D009153:Mutagens; D013949:Thymus Extracts; C051006:thymomodulin