title: Sexual behavior and sexual orientation of the female rat after hormonal treatment during various stages of development.
abstract: The amount of circulating sex steroids during Postnatal Days 30-90 was varied in normally developed and in androgenized female rats. The influence of these manipulations on sexual behavior and sexual orientation was investigated. Normally developed or neonatally androgenized females were ovariectomized and implanted with estradiol through Postnatal Days 30-90 or sham-implanted. The remaining subjects were left intact during that period. The hormonal condition during Postnatal Days 30-90 significantly affected the behavior of normally developed females, but affected the behavior of neonatally androgenized females only to minor extent. Estrogen implants in normally developed females enhanced masculine sexual responses and induced a female-directed sexual orientation. Feminine sexual responses were unaffected by this treatment. Sham-implanted, normally developed females showed a male-directed sexual orientation and fewer masculine sexual responses than subjects which were left intact during Postnatal Days 30-90. Neonatal androgen treatment in general resulted in elevated levels of masculine Neonatal androgen treatment in general resulted in elevated levels of masculine sexual responses, inhibited feminine sexual behavior, and facilitated a female-directed sexual orientation.
authors.affiliation: Netherlands Institute for Brain Research, Amsterdam.
authors.forename: F H
authors.initials: FH
authors.lastname: de Jonge
authors.forename: J W
authors.initials: JW
authors.lastname: Muntjewerff
authors.forename: A L
authors.initials: AL
authors.lastname: Louwerse
authors.forename: N E
authors.initials: NE
authors.lastname: van de Poll
mesh_terms: D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects; D010052:Ovariectomy; D011187:Posture; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D013739:Testosterone; D004958:Estradiol