The elimination of furazolidone and its open-chain cyano-derivative from adult swine.
1. A sensitive method for the determination of 3-(4-cyano-2-oxobutylidene amino)-2-oxazolidone, the open-chain cyano-derivative of the veterinary drug furazolidone, in swine plasma and tissues is described. 2. After dosing adult swine orally with furazolidone (690 mg/animal per day) for 10 days no furazolidone was detected in liver, kidney and muscle (less than 2 ng/g). The half life of furazolidone as measured from the terminal phase of the plasma curves was 45 minutes. In urine, small amounts (less than 0.3% of total dose) of furazolidone were detected. 3. In contrast to other animals, 3-(4-cyano-2-oxobutylidene amino)-2-oxazolidone is a minor metabolite in swine with a plasma half life of 4 h. No cyano-derivative was detected in liver and kidney (less than 5 ng/g) 2 h after the last administration of furazolidone; 24 h after the last administration, the concentration in plasma was less than 2 ng/ml and in muscle less than 5/g. 4. The cyano-derivative was not mutagenic in the Salmonella/microsome test, with or without metabolic activation.
Vroomen
L H
LH
State Institute for Quality Control of Agricultural Products (RIKILT), Section Toxicology, Wageningen, The Netherlands.
Berghmans
M C
MC
Hekman
P
P
Hoogenboom
L A
LA
Kuiper
H A
HA
D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D004926:Escherichia coli / Q000378:metabolism; D005664:Furazolidone / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009152:Mutagenicity Tests; D012997:Solvents; D013552:Swine; D013997:Time Factors
D012997:Solvents; D005664:Furazolidone