Small-intestinal factors promote encystation of Giardia lamblia in vitro.
Bile salts and fatty acids stimulated differentiation of cultured Giardia lamblia trophozoites into water-resistant cysts at the slightly alkaline pH of the small intestinal lumen. Maximum encystation occurred at pH 7.8. Thus, specific small-intestinal factors may influence encystation in vivo as well as in vitro.
Gillin
F D
FD
Department of Pathology, University of California San Diego 92103.
Reiner
D S
DS
Boucher
S E
SE
D000818:Animals; D001647:Bile Acids and Salts / Q000502:physiology; D005227:Fatty Acids / Q000502:physiology; D005872:Giardia / Q000166:cytology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000469:parasitology*
D001647:Bile Acids and Salts; D005227:Fatty Acids