title: Reconstruction of mandibular defects with metallic prostheses and microvascular jejunal autografts: an experimental study.
abstract: A study was undertaken to determine the adequacy of vascularised jejunum to provide stable mucosal cover over a non-biological mandibular substitute. Employing a canine model, composite intra-oral bone-mucosal defects were created and reconstructed with a metal plate covered by a microvascular jejunal patch. These were followed for six months and were assessed clinically, histologically and radiologically. Rapid mucosal healing occurred in all cases. The autografts conformed to the contour of the prosthesis and adequate tongue mobility was preserved. All mandibles remained stable throughout the follow-up period. Histologically, short villi covered the jejunal grafts to three months whilst at six months both normal and abnormal jejunal mucosal morphology was evident.
authors.affiliation: Microsurgery Research Centre, St Vincent's Hospital, Melbourne, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Sheen
authors.forename: A M
authors.initials: AM
authors.lastname: MacLeod
authors.forename: G M
authors.initials: GM
authors.lastname: Mitchell
authors.forename: B M
authors.initials: BM
authors.lastname: O'Brien
mesh_terms: D000818:Animals; D002858:Chromium Alloys; D004285:Dogs; D007413:Intestinal Mucosa / Q000637:transplantation; D007583:Jejunum / Q000637:transplantation*; D008341:Mandibular Prosthesis; D013524:Surgical Flaps
chemical_list: D002858:Chromium Alloys