Neurogenic stimuli alter preoptic area and amygdala unit activity: central effects of olfactory projections on paraventricular nucleus units.
Unit responses were recorded in the preoptic area and amygdala of conscious male rats during exposure to stressful neurogenic stimuli. Olfactory stimulation elicited increases in preoptic area activity on all occasions and also increased activity in the intercalating, medial, and basomedial nuclei of the amygdala, but not in other regions. Acoustic stimulation had less specific effects, even inhibiting unit activity in the central amygdala. A separate series of experiments using urethane-anesthetized rats was carried out to examine the effects of electrical stimulation of the medial amygdala and olfactory tubercle on single-unit activity within the hypothalamic paraventricular nucleus. Inhibition was the predominant response following olfactory tubercle stimulation while excitatory responses predominated following stimulation of the medial amygdala. This was the case particularly for those paraventricular nucleus units identified as projecting to the median eminence (P less than 0.005 vs unidentified cells). The results obtained may be related to the neural regulation of adrenocortical activity as well as higher central nervous activity and have been discussed within these contexts.
Saphier
D
D
Department of Neurology, Hadassah University Hospital, Jerusalem, Israel.
Mor
G
G
Feldman
S
S
D000161:Acoustic Stimulation; D000679:Amygdala / Q000503:physiopathology*; D000818:Animals; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D009830:Olfactory Bulb / Q000503:physiopathology*; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D011301:Preoptic Area / Q000503:physiopathology*; D051381:Rats; D012903:Smell / Q000502:physiology; D013312:Stress, Physiological / Q000503:physiopathology*