Binucleated cells in a human renal cell carcinoma with 34 chromosomes.
Cytogenetic analysis of a human renal cell carcinoma revealed a near-haploid chromosome number of 34 with the loss of one chromosome #1, #2, #3, #6, #7, #9, #10, #12, #13, #17, #18, and #21. Binucleated cells were observed in histologic, cytologic, as well as in cytogenetic preparations. The paper briefly discusses the binucleation-polyploidization as a possible compensatory mechanism to maintain the genetic balance in near-haploid cells.
Kovacs
G
G
Laboratory of Cytogenetics, Hannover Medical School, Federal Republic of Germany.
Soudah
B
B
Hoene
E
E
D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D002871:Chromosome Banding; D002872:Chromosome Deletion; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011003:Ploidies