title: Chronic treatment with choline or scopolamine indicates the presence of muscarinic cholinergic receptor plasticity in the frontal cortex of young but not of aged mice.
abstract: Chronic treatment (2 weeks) with either scopolamine (4 mg/kg, once daily p.o.) or choline (200 mg/kg, once daily p.o.) resulted in a pronounced muscarinic cholinergic receptor up- or down-regulation in the frontal cortex of young (4 weeks) but not of aged (18 months) female mice. It is speculated that a similar age-related decline of muscarinic receptor plasticity might contribute to the profound dysfunction of cholinergic neurotransmission in Alzheimer's disease.
authors.affiliation: Zentralinstitut für Seelische Gesundheit, Mannheim, Federal Republic of Germany.
authors.forename: H
authors.initials: H
authors.lastname: Pilch
authors.forename: W E
authors.initials: WE
authors.lastname: Müller
mesh_terms: D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D002794:Choline / Q000494:pharmacology*; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D051379:Mice; D008954:Models, Biological; D011976:Receptors, Muscarinic / Q000187:drug effects* / Q000378:metabolism; D012601:Scopolamine / Q000494:pharmacology*
chemical_list: D011976:Receptors, Muscarinic; D012601:Scopolamine; D002794:Choline