Extracellular iron chelation in Cryptococcus neoformans.
Low-iron minimal medium supported growth of Cryptococcus neoformans but spent medium contained no hydroxamates, organic acids or other iron chelators. Exogenous deferoxamine stimulated growth in extreme iron-limitation, while neither organic acids nor quartersaturated transferrins were stimulatory. These results suggest two iron uptake mechanisms, one dependent upon exogenous hydroxamate, the other hydroxamate-independent.
Jacobson
E S
ES
Research Service, McGuire Veterans Administration Medical Center, Richmond, Virginia 23249.
Petro
M J
MJ
D003454:Cryptococcus / Q000378:metabolism*; D003455:Cryptococcus neoformans / Q000254:growth & development / Q000378:metabolism*; D003470:Culture Media; D006863:Hydrogen-Ion Concentration; D007502:Iron Chelating Agents / Q000378:metabolism*
D003470:Culture Media; D007502:Iron Chelating Agents