Median cleft face syndrome: MR and CT data from 11 children.
Examination (including CT and magnetic resonance studies) of 11 unrelated children with median cleft face syndrome revealed 6 (55%) with dense calcification of the falx and 5 (45%) with interhemispheric lipoma. Of the 11 children, 3 exhibited Sedano facies type A, 4 exhibited Sedano facies type B, and 4 exhibited Sedano facies type D. Type A patients had no calcification or lipoma. Two of three type A patients were products of separate twin gestations, the only twins in the series. Type B patients had frequent falx calcification (three of four) and interhemispheric lipoma (two of four). Two of the four type B patients had concurrent Goldenhar syndrome, the only such patients in the series. Type D patients also had frequent falx calcification (three of four) and interhemispheric lipoma (three of four). Patients with median cleft face syndrome and Sedano facies type B or D should be examined radiologically for concurrent intracranial pathology.
Naidich
T P
TP
Department of Radiology, Children's Memorial Hospital, Chicago, IL.
Osborn
R E
RE
Bauer
B
B
Naidich
M J
MJ
D001932:Brain Neoplasms / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D005147:Facial Bones / Q000002:abnormalities*; D005149:Facial Expression; D005260:Female; D006801:Humans; D006972:Hypertelorism / Q000175:diagnosis; D007223:Infant; D007231:Infant, Newborn; D008067:Lipoma / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D012886:Skull / Q000002:abnormalities*; D013577:Syndrome; D014057:Tomography, X-Ray Computed