title: Comparative evaluation of aloe vera in the management of burn wounds in guinea pigs.
abstract: An experimental study was designed using Hartley guinea pigs, who received full-thickness burns covering 3 percent of their body surface area by direct contact with a hot plate. A total of 40 animals were equally divided among four modalities of closed burn wound management as follows: group I: silver sulfadiazine (Silvadine); group II: aloe vera gel extract (Carrington Dermal Wound Gel); group III: salicylic acid cream (aspirin); and group IV: plain gauze occlusive dressing only. The dressings were changed daily, and the size and appearance of each burn wound were recorded until complete healing. On the sixth postburn day, quantitative burn wound cultures were made. The average time to complete healing in the control group was 50 days, and the only significant difference was found in the aloe vera-treated animals, which healed on an average of 30 days (p less than 0.02). Wound bacterial counts were effectively decreased by silver sulfadiazine (p = 0.015) and by aloe vera extract (p = 0.015). From our data it appears that aloe gel extracts permit a faster healing of burn wounds.
authors.affiliation: Surgical Research Laboratories, University of Puerto Rico School of Medicine, San Juan.
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez-Bigas
authors.forename: N I
authors.initials: NI
authors.lastname: Cruz
authors.forename: A
authors.initials: A
authors.lastname: Suárez
mesh_terms: D000287:Administration, Topical; D000504:Aloe; D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control; D002056:Burns / Q000628:therapy*; D004195:Disease Models, Animal; D005782:Gels; D006168:Guinea Pigs; D008297:Male; D009779:Occlusive Dressings; D009824:Ointments; D010946:Plants, Medicinal; D012459:Salicylates / Q000008:administration & dosage / Q000627:therapeutic use; D012837:Silver Sulfadiazine / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects; D014946:Wound Infection / Q000517:prevention & control
chemical_list: D005782:Gels; D009824:Ointments; D012459:Salicylates; D012837:Silver Sulfadiazine