title: A first approach to an action spectrum for 8-MOP phototumorigenesis in mice.
abstract: Groups of hairless albino mice were treated with 8-MOP and exposed to a fixed daily dose of UVR obtained from one of four different emission spectra. Each spectrum was obtained by filtering a xenon arc source with a different WG filter. The resultant spectra showed differences in their proportions of shorter UVA wavelengths. A decreased proportion of the shorter wave bands systematically increased the time to first tumor. These data suggest that the action spectrum for 8-MOP sensitized phototumorigenesis is similar to that of acute 8-MOP action spectra in mammalian skin, which usually show maximal activity in the 320-335 nm region.
authors.affiliation: Department of Photobiology, United Medical School, Guy's Hospital, London, England.
authors.forename: A R
authors.initials: AR
authors.lastname: Young
authors.forename: S L
authors.initials: SL
authors.lastname: Walker
authors.forename: M
authors.initials: M
authors.lastname: Garmyn
mesh_terms: D000818:Animals; D004247:DNA / Q000378:metabolism; D005260:Female; D008730:Methoxsalen / Q000378:metabolism / Q000633:toxicity*; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D004247:DNA; D008730:Methoxsalen