[Sensitivity of the splenic cells of different mouse strains to the antiproliferative action of alkylating compounds].
A method of quantitative evaluation of lymphocytes' sensitivity to the antiproliferative effect of the alkylating drugs has been developed. Chlorbutin, mafosfamide (Asta Z 7654) and "active" metabolites of cyclophosphamide were studied. This research allowed to distinguish more sensitive strains (DBA/2 and C57BL/6) and those with low sensitivity (BALB/c and CC57BR). These differences do not depend on proliferation reaction, neither on the type of alkylating drugs nor haplotypes H-2.
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D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002699:Chlorambucil / Q000494:pharmacology; D003520:Cyclophosphamide / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000494:pharmacology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005838:Genotype; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D013154:Spleen / Q000166:cytology / Q000187:drug effects*
D000477:Alkylating Agents; D002699:Chlorambucil; D003520:Cyclophosphamide; C047251:mafosfamide-lysine
Chuvstvitel'nost' kletok selezenki mysheĭ raznykh liniĭ k antiproliferativnomu deĭstviiu alkiliruiushchikh soedineniĭ.