title: Hormonal regulation of sodium-fluid balance and some hemodynamic parameters in the rat. II. The effect of sodium depletion and sodium loading on rats with inherited diabetes insipidus (Brattleboro strain).
abstract: The effect of furanthril after an acute (24 hours) and chronic administration (7 days), and the effect of 7-days sodium loading was followed on control Long Evans (LE) and Brattleboro rats with inherited hypothalamic diabetes insipidus (DI). In addition to the routine sodium-fluid balance study, plasma renin activity and prostaglandins excretion were examined. In control LE rats was found a typical diuretic- and natriuretic effect of furanthril only after an acute (14 hours) administration of the drug. This effect was attributed to the stimulation of renal PGE2 synthesis. In sodium-depleted state (7 days after administration of furanthril) the diuretic- and natriuretic effect was missing due to the extensive sodium deficit. In DI rats was found a paradoxical antidiuretic effect of furanthril after either an acute or chronic treatment, which was attributed to the per se stimulated renin-angiotensin system and suppressed PG-synthesis typical for these rats. The conclusion of this studies was that an availability of ADH is necessary for PG-response to sodium depletion. After sodium loading, an exaggerated natriuresis, decreased PRA, and depressed PG-synthesis was found in DI rats. The feedback mechanism between renin axis and prostaglandin system in the absence of ADH was discussed.
authors.affiliation: Institute of Endocrinology, Gerontology and Geriatrics, Medical Academy, Sofia.
authors.forename: L
authors.initials: L
authors.lastname: Somova
mesh_terms: D000818:Animals; D001581:Benzothiadiazines; D003919:Diabetes Insipidus / Q000378:metabolism*; D004232:Diuretics; D005665:Furosemide / Q000494:pharmacology; D008297:Male; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D011910:Rats, Brattleboro; D012083:Renin / Q000378:metabolism*; D012964:Sodium / Q000172:deficiency / Q000378:metabolism* / Q000494:pharmacology; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology; D014667:Vasopressins / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
chemical_list: D001581:Benzothiadiazines; D004232:Diuretics; D011453:Prostaglandins; D049993:Sodium Chloride Symporter Inhibitors; D014667:Vasopressins; D005665:Furosemide; D012964:Sodium; D012083:Renin