Re-irradiation of mouse skin: similarity of dose reductions for healing and macrocolony endpoints.
The amount of residual injury in mouse tail skin, assessed by the decrease in re-irradiation dose for equal effect, was similar whether assessed using healing or colony endpoints (17-21% after single priming doses). There were tendencies towards an increased sensitivity of the colony-forming cells by a factor of about 2, and less residual injury after multifractionated priming doses. These observations are compatible with a lower alpha/beta ratio characterising the response to dose fractionation for residual injury than for the acute healing response.
Chen
F D
FD
Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K.
Hendry
J H
JH
D000818:Animals; D002470:Cell Survival; D004307:Dose-Response Relationship, Radiation; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009336:Necrosis; D012867:Skin / Q000166:cytology / Q000528:radiation effects*; D013234:Stem Cells / Q000528:radiation effects; D014945:Wound Healing