Alcoholic hepatitis in females.
In the period 1970-1984 alcoholic hepatitis was diagnosed by liver biopsy in 52 females. Thirty-six patients with cirrhosis were generally in a worse clinical and biochemical state than those without cirrhosis. Biochemical tests for liver function showed significant improvement from admission to the time of liver biopsy. At follow-up liver function tests were generally better in patients who had stopped drinking alcohol compared to those who continued to do so. The 5-year survival rate was 82% for females without cirrhosis, and 45% for those with cirrhosis (p less than 0.03). Considering the sex-related differences in alcohol abuse in the general population we found no evidence of increased susceptibility to the hepatotoxic effect of alcohol in females.
Milman
N
N
Department of Internal Medicine B, Bispebjerg Hospital, Copenhagen, Denmark.
Graudal
N
N
Strøm
P
P
Franzmann
M B
MB
D000328:Adult; D000368:Aged; D003718:Denmark; D005260:Female; D005500:Follow-Up Studies; D006519:Hepatitis, Alcoholic / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies