Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells.
We have isolated and sequenced two cDNA clones coding for plasminogen activator inhibitor 2 (PAI-2). The cDNA was used to study the regulation of PAI-2 gene transcription by the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate in the human histiocytic lymphoma cell line U-937. The tumor promoter caused a transient, 50-fold increase of PAI-2 gene transcription.
Schleuning
W D
WD
Department of Medicine, University Hospital Center, CHUV, Lausanne, Switzerland.
Medcalf
R L
RL
Hession
C
C
Rothenbühler
R
R
Shaw
A
A
Kruithof
E K
EK
D001483:Base Sequence; D002454:Cell Differentiation / Q000187:drug effects; D004247:DNA / Q000235:genetics; D004274:DNA, Recombinant; D004926:Escherichia coli / Q000235:genetics; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism / Q000473:pathology*; D008969:Molecular Sequence Data; D010957:Plasmids; D015849:Plasminogen Inactivators; D012333:RNA, Messenger / Q000096:biosynthesis; D013698:Templates, Genetic; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects*; D014170:Transformation, Genetic; D014407:Tumor Cells, Cultured
D004274:DNA, Recombinant; D006023:Glycoproteins; D015849:Plasminogen Inactivators; D012333:RNA, Messenger; D004247:DNA; D013755:Tetradecanoylphorbol Acetate