Fatal paracetamol poisoning in an epileptic.
Treatment nomograms are used in paracetamol poisoning for indicating when antidotes should be given to prevent hepatic or renal damage. We report a fatal case of paracetamol poisoning in an epileptic taking phenytoin, in whom no antidotal treatment was given because it was not indicated.
Minton
N A
NA
Poisons Unit, Guy's Hospital, London, UK.
Henry
J A
JA
Frankel
R J
RJ
D000082:Acetaminophen / Q000506:poisoning*; D000328:Adult; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use; D000078306:Clobazam; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004347:Drug Interactions; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008297:Male; D010672:Phenytoin / Q000494:pharmacology / Q000627:therapeutic use*; D011324:Primidone / Q000627:therapeutic use
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; D011324:Primidone; D000078306:Clobazam; D000082:Acetaminophen; D010672:Phenytoin; D003577:Cytochrome P-450 Enzyme System