title: A 15-kDa interferon-induced protein is derived by COOH-terminal processing of a 17-kDa precursor.
abstract: An interferon-induced 15-kDa protein is synthesized from a precursor of higher molecular weight; the precursor contains 165 amino acids (17 kDa), whereas the stable product (15 kDa) contains 156 amino acids. The stable 15-kDa form is derived from the precursor 17-kDa form by the removal of eight amino acids from the COOH terminus and the methionine from the NH2 terminus. The existence of the precursor 17-kDa protein can be demonstrated after brief periods of in vivo labeling with [35S]methionine and by translation of mRNA in vitro.
authors.affiliation: Central Research and Development Department, E. I. du Pont de Nemours and Company, Inc., Wilmington, Delaware 19898.
authors.forename: E
authors.initials: E
authors.lastname: Knight
authors.forename: D
authors.initials: D
authors.lastname: Fahey
authors.forename: B
authors.initials: B
authors.lastname: Cordova
authors.forename: M
authors.initials: M
authors.lastname: Hillman
authors.forename: R
authors.initials: R
authors.lastname: Kutny
authors.forename: N
authors.initials: N
authors.lastname: Reich
authors.forename: D
authors.initials: D
authors.lastname: Blomstrom
mesh_terms: D000595:Amino Acid Sequence; D002460:Cell Line; D003488:Cyanogen Bromide; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D014176:Protein Biosynthesis; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000235:genetics
chemical_list: D007370:Interferon Type I; D009363:Neoplasm Proteins; D011506:Proteins; D003488:Cyanogen Bromide