title: Long-term occlusion of the porcine cystic duct by means of endoluminal radio-frequency electrocoagulation.
abstract: Recurrent cholelithiasis must be expected after gallstone removal without cholecystectomy. Chemical gallbladder ablation may offer prevention but requires preliminary cystic duct occlusion. Radio-frequency (RF) electrocoagulation of the cystic duct was performed in 15 pigs to induce occlusion by a controlled thermal epithelial injury. A flexible coagulation catheter was placed into the cystic duct lumen under fluoroscopic control by means of either subhepatic cholecystostomy or direct, percutaneous transhepatic gallbladder puncture. Complete cystic duct occlusion was proved in 14 animals. Follow-up ranged from 1 to 17 weeks (mean, 11 weeks). Histologically, the RF technique induced an intense chronic inflammatory and fibroblastic reaction, which eventually obliterated the coagulated cystic duct segments. There was no epithelial regeneration or recanalization of the fibrotic cystic duct segments. The adjacent structures, particularly the cystic artery, were intact in all specimens.
authors.affiliation: Department of Radiology, University of British Columbia, Vancouver, Canada.
authors.forename: C D
authors.initials: CD
authors.lastname: Becker
authors.forename: N F
authors.initials: NF
authors.lastname: Quenville
authors.forename: H J
authors.initials: HJ
authors.lastname: Burhenne
mesh_terms: D000818:Animals; D002769:Cholelithiasis / Q000517:prevention & control; D003549:Cystic Duct / Q000601:surgery*; D004564:Electrocoagulation / Q000379:methods*; D005500:Follow-Up Studies; D011846:Radio Waves; D012008:Recurrence; D013552:Swine; D013997:Time Factors