Acetaminophen protects human erythrocytes against oxidative stress.
Acetaminophen protects human erythrocytes against various modes of oxidative stress. Protection against ozone-induced damage can be explained by a direct scavenging reaction between the drug and ozone. With t-butylhydroperoxide acetaminophen appeared to be an effective scavenger of radicals, generated in secondary reactions. The protection by acetaminophen against t-butylhydroperoxide- and hydrogen peroxide-induced lipid peroxidation and K+-leakage can be explained along these lines. In all cases the protective effect of acetaminophen was attended with covalent binding of acetaminophen to membrane proteins.
Van der Zee
J
J
Center for Bio-Pharmaceutical Sciences, Division of Toxicology, Leiden, The Netherlands.
Mulder
G J
GJ
Van Steveninck
J
J
D000082:Acetaminophen / Q000378:metabolism / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000096:biosynthesis; D010084:Oxidation-Reduction; D010126:Ozone / Q000494:pharmacology*; D010545:Peroxides / Q000494:pharmacology*; D020122:tert-Butylhydroperoxide
D005609:Free Radicals; D008054:Lipid Peroxides; D010545:Peroxides; D000082:Acetaminophen; D010126:Ozone; D020122:tert-Butylhydroperoxide; D006861:Hydrogen Peroxide