Infiltration of Leu-3a+3b-positive lymphocytes and expression of human leukocyte antigen DR on tumor tissue induced by radiation therapy.
Tumor infiltrating lymphocytes induced by radiotherapy were analyzed by the biotin-avidin-horseradish peroxidase method. At the early dose of 4 Gy (400 rad) of irradiation (2 Gy X 2), remarkable infiltration of lymphocytes was observed surrounding cancer cells. This infiltration was mainly composed of Leu-3a+3b-positive lymphocytes, and human leukocyte antigen DR-positive tumor and interstitial cells were remarkably observed.
Ogawa
Y
Y
Department of Radiology, Kochi Medical School, Japan.
Maeda
T
T
Seguchi
H
H
Hamada
F
F
Inomata
T
T
Yoshida
S
S
Kishimoto
S
S
Saito
H
H
D000368:Aged; D000943:Antigens, Differentiation / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology*; D006681:HLA-D Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000276:immunology / Q000473:pathology*; D010610:Pharyngeal Neoplasms / Q000276:immunology / Q000473:pathology*
D000943:Antigens, Differentiation; D006681:HLA-D Antigens; D006684:HLA-DR Antigens