[Homeostatic role of calcitonin antibodies in calcium metabolism in experimental diabetes mellitus].
In experimental alloxan diabetes marked hypocalcemia and hyperglycemia are observed in the blood of rats during the acute period of the disease (from 1.5 to 2 months). After 2.5-3.5 months of diabetes calcium level reaches the upper normal limit. Simultaneously, antibodies to calcitonin appear. It is quite likely that excessive calcitonin secretion, leading to hypocalcemia, decreased insulin secretion and hyperglycemia take place in the acute stage of diabetes. When diabetes persists the antibodies to calcitonin which reveal a homeostatic reaction blocking the excess of calcitonin appear. This normalizes the level of calcium in the blood and prevents the further increase in the blood sugar level.
Kulikova
L I
LI
Tsvetkov
V S
VS
Gordienko
S P
SP
Bondarenko
M F
MF
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D001786:Blood Glucose / Q000032:analysis; D002116:Calcitonin / Q000276:immunology*; D002118:Calcium / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000276:immunology; D006706:Homeostasis; D006943:Hyperglycemia / Q000097:blood / Q000276:immunology; D008297:Male; D051381:Rats
D000906:Antibodies; D001786:Blood Glucose; D002116:Calcitonin; D002118:Calcium
Gomeostaticheskaia rol' antitel k kal'tsitoninu v obmene kal'tsiia pri éksperimental'nom sakharnom diabete.