title: Midazolam for induction of anaesthesia in patients with limited cardiac reserves. A comparison with etomidate.
abstract: The new water-soluble benzodiazepine, midazolam (Dormicum; Roche), was compared with etomidate as part of a balanced technique for induction of anaesthesia in 16 patients undergoing cardiac valve replacement. Monitoring revealed a significantly greater fall in blood pressure in patients receiving midazolam (reaching dangerous levels in 2 patients), which suggests that this agent is not suitable for induction of anaesthesia in haemodynamically compromised patients.
authors.affiliation: Department of Anaesthetics, University of Natal, Durban.
authors.forename: R G
authors.initials: RG
authors.lastname: MacGillivray
authors.forename: D A
authors.initials: DA
authors.lastname: Rocke
authors.forename: A E
authors.initials: AE
authors.lastname: Mahomedy
mesh_terms: D000328:Adult; D000768:Anesthesia, General / Q000379:methods*; D001794:Blood Pressure / Q000187:drug effects*; D005045:Etomidate / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006351:Heart Valves / Q000637:transplantation; D006801:Humans; D008297:Male; D008874:Midazolam / Q000494:pharmacology*; D011897:Random Allocation; D013997:Time Factors
chemical_list: D008874:Midazolam; D005045:Etomidate