[The eye and chronic inflammatory diseases of the intestines. Immunopathological and genetic aspects. Apropos of 3 cases].
This study tried to approximate the mechanisms of ocular changes in Crohn's disease and ulcerative colitis. First, we reported a series of three patients with ocular complications and chronic inflammatory bowel disease. In all cases, we reported the association of ocular disorders with: various infections: intestinal, extra-intestinal complications, immunological troubles, genetic background: HLA B 27. Second, we reviewed the literature concerning ocular changes in ulcerative colitis and Crohn's disease. Recent immunological developments are studied, regarding: genetic aspects, allergic manifestations. immune complexes and role of IgA antibodies. Practically, uveitis, retinal inflammation or vasculitis can be associated with Crohn's disease and ulcerative colitis. Immunological studies of these patients will allow a better understanding of the mechanisms of the ocular lesions, which remain is complex, multiple and non specific.
Raby
O
O
Centre Hospitalier Intercommunal, Service d'Ophtalmologie, Villeneuve-Saint-Georges.
Salvanet-Bouccara
A
A
Forestier
F
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003093:Colitis, Ulcerative / Q000150:complications* / Q000235:genetics / Q000276:immunology; D003424:Crohn Disease / Q000150:complications* / Q000235:genetics / Q000276:immunology; D005128:Eye Diseases / Q000209:etiology*; D005260:Female; D006801:Humans
Oeil et maladies inflammatoires chroniques de l'intestin. Aspects immunopathologiques et génétiques. A propos de trois observations.