Nasal pharmacodynamics of brompheniramine in perennial rhinitis.
This study evaluated the relationship between brompheniramine maleate and changes in nasal reactivity. Ten subjects with moderate-to-severe perennial rhinitis took brompheniramine for seven days using either a standard formulation or sustained-release preparation. Nasal aerodynamics and response to histamine were assessed at the end of the week. Despite varying doses of brompheniramine maleate (12 to 32 mg/d), there was no significant difference in nasal reactivity to histamine or in changes of nasal airflow, indicating that low doses of brompheniramine are highly effective in blocking histamine, receptors in the nasal mucosa.
Georgitis
J W
JW
Department of Pediatrics, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27103.
Shen
D
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D000293:Adolescent; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D001977:Brompheniramine / Q000008:administration & dosage / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D005260:Female; D006632:Histamine; D006801:Humans; D008297:Male; D009296:Nasal Cavity / Q000503:physiopathology; D011725:Pyridines / Q000627:therapeutic use*; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology
D003692:Delayed-Action Preparations; D011725:Pyridines; D006632:Histamine; D001977:Brompheniramine