title: Metabolism of chloral hydrate in the anoxic perfused liver.
abstract: The metabolism of chloral hydrate (CH) under anoxic conditions was investigated in the non-recirculating, hemoglobin-free liver perfusion system. CH uptake in the anoxic liver decreased to about 80% of that in the oxygen-supplied liver. The reduction of CH to trichloroethanol (TCE) increased and the oxidation of CH to trichloroacetic acid (TCA) decreased. The TCE/TCA ratio increased; however, the total trichloro compounds, that is TCE and TCA, were not significantly altered by anoxia. Though approximate 14% of the CH infused into the oxygen-supplied liver was changed to substances other than TCE or TCA, the unknown part was a very small portion in the anoxic liver. The decrease in CH uptake, by the anoxic liver, is thought to be equivalent to the decrease of the unknown metabolites. The TCE/TCA ratio under anoxia was also altered by pyruvate or lactate infusion.
authors.affiliation: Department of Public Health, Yamaguchi University School of Medicine, Ube, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kawamoto
authors.forename: T
authors.initials: T
authors.lastname: Hobara
authors.forename: T
authors.initials: T
authors.lastname: Aoki
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Iwamoto
authors.forename: T
authors.initials: T
authors.lastname: Sakai
authors.forename: T
authors.initials: T
authors.lastname: Takano
authors.forename: Y
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: A
authors.initials: A
authors.lastname: Imamura
authors.forename: K
authors.initials: K
authors.lastname: Ogino
mesh_terms: D000818:Animals; D002697:Chloral Hydrate / Q000378:metabolism*; D007773:Lactates / Q000494:pharmacology; D019344:Lactic Acid; D008099:Liver / Q000378:metabolism*; D008297:Male; D010100:Oxygen / Q000032:analysis*; D010477:Perfusion; D011773:Pyruvates / Q000494:pharmacology; D019289:Pyruvic Acid; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D002697:Chloral Hydrate; D019289:Pyruvic Acid; D010100:Oxygen