The antidysrhythmic effect of metoprolol in the epinephrine treated chick embryo.
It was confirmed through electrocardiography that within two hours after epinephrine treatment, four day chick embryos either maintained normal rhythm or developed a severe cardiac dysrhythmia (22/93, 24% dysrhythmic). The ECG dysrhythmia in epinephrine treated embryos were characterized by periods of bradycardia, asystole, and various supraventricular or ventricular dysrhythmias. Within four hours after treatment, dysrhythmic embryos either reestablished normal rhythmicity or died. Electrocardiographic data also demonstrated that metoprolol pretreatment will block epinephrine induced dysrhythmias (0/46, 0% dysrhythmic). We conclude that metoprolol possesses antidysrhythmic properties in the epinephrine treated chick embryo.
Kolesari
G L
GL
Department of Anatomy and Cellular Biology, Medical College of Wisconsin, Milwaukee 53226.
Schnitzler
H J
HJ
Rajala
G M
GM
Lewan
R B
RB
Kaplan
S
S
D000818:Animals; D002642:Chick Embryo; D004562:Electrocardiography; D004837:Epinephrine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D008790:Metoprolol / Q000494:pharmacology*; D013997:Time Factors
D008790:Metoprolol; D004837:Epinephrine