The effects of steroidal and nonsteroidal anti-inflammatory agents on uptake of Evans blue in experimental metastasis.
The effects of anti-inflammatory drugs on uptake of Evans blue were studied in solitary Walker carcinosarcomas implanted in the livers of Sprague-Dawley rats. Animals were sacrificed at 5 min, 30 min, and 6 hr after administration of the anti-inflammatory drugs and Evans blue, and spectrophotometric measurements of the Evans blue in tumor and normal liver tissue were carried out. Uptake of Evans blue in the tumors was significantly decreased at all time periods after the injection of the following, as compared to controls: steroids (cortisol, methylprednisolone, and triamcinolone), the antihistamine diphenhydramine, and nonsteroidal anti-inflammatory agents (naproxen, ibuprofen, indomethacin, and phenylbutazone). The effects of these drugs on uptake of Evans blue in the normal liver were more variable.
Ackerman
N B
NB
Department of Surgery, Metropolitan Hospital Center, New York Medical College, New York 10029.
Jacobs
R
R
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001391:Azo Compounds / Q000378:metabolism*; D002199:Capillary Permeability; D002279:Carcinoma 256, Walker / Q000098:blood supply / Q000378:metabolism / Q000556:secondary*; D003864:Depression, Chemical; D005070:Evans Blue / Q000378:metabolism*; D008099:Liver / Q000098:blood supply / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000378:metabolism / Q000556:secondary*; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001391:Azo Compounds; D005070:Evans Blue