[Antibacterial and antifungal compounds. VIII. Synthesis and antifungal activity of pyrrol derivatives similar to trichostatin A].
Some p-methylbenzolpyrrole acrylic acids and related compounds were synthesized. The new pyrrole derivatives have structural features in common with trichostatin A, an antifungal antibiotic. The above acids and derivatives were tested against Candida albicans and Candida sp in comparison with miconazole, pyrrolnitrin and amphotericin B and showed very weak antifungal activities. Occasionally some activity was found against a few strains of Candida albicans and against Candida pseudotropicalis.
Corelli
F
F
Istituto di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia, Università di Roma La Sapienza.
Massa
S
S
Stefancich
G
G
Mai
A
A
Artico
M
M
Panico
S
S
Simonetti
N
N
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D006877:Hydroxamic Acids; D011758:Pyrroles; C012589:trichostatin A
Ricerche su composti antibatterici ed antifungini. Nota VIII. Sintesi ed attività antifungina di derivati pirrolici correlati con la tricostatina A.