title: Stabilizing blood glucose with a novel medical expert system.
abstract: In health, metabolism is elegantly coordinated. Failure of an underlying process (as occurs in diabetes) disrupts the coordination and impacts on the global status of the affected individual. It takes a medical expert to intervene and restore order. Chaotic processes prevail at all times in biological systems and their behaviour in sickness degenerates between medical interventions. We have explored the use of an expert system to substitute for the physician between interventions and demonstrated its ability to maintain order and thus significantly improve control of blood glucose.
authors.affiliation: Biomedical Research Division, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: W D
authors.initials: WD
authors.lastname: Lougheed
authors.forename: A
authors.initials: A
authors.lastname: Schiffrin
authors.forename: A M
authors.initials: AM
authors.lastname: Albisser
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D015374:Biosensing Techniques; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D002985:Clinical Protocols; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy; D005103:Expert Systems; D006801:Humans; D007003:Hypoglycemia / Q000517:prevention & control; D007328:Insulin / Q000008:administration & dosage; D008838:Microcomputers
chemical_list: D001786:Blood Glucose; D007328:Insulin