title: Renotropic activity of lutropin: direct stimulation of DNA synthesis of cultured rat renal cortical cells.
abstract: Two differently purified ovine lutropin (LH) preparations were studied to see if they stimulated [3H] thymidine incorporation into cultured rat renal cortical cells. Both preparations showed a dose-dependent (0.11-1 ng/ml), time-dependent (peaking at 18 h), serum-dependent (7.5% of fetal calf serum or 10% castrated-hypo-physectomized rat serum) renotropic effect. Ovine TSH and FSH failed to mimic this specific, renotropic effect. We concluded that LH directly stimulates renal DNA synthesis in cooperation with other serum factor's.
authors.affiliation: Department of Medicine, Tokyo Women's Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nomura
authors.forename: N
authors.initials: N
authors.lastname: Horiba
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Ujihara
authors.forename: H
authors.initials: H
authors.lastname: Demura
authors.forename: K
authors.initials: K
authors.lastname: Shizume
mesh_terms: D000818:Animals; D002369:Castration; D002417:Cattle; D004247:DNA / Q000096:biosynthesis*; D005312:Fetal Blood; D007016:Hypophysectomy; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007986:Luteinizing Hormone; D004247:DNA