Investigation of cereal toxicity in coeliac disease.
Coeliac disease is exacerbated by wheat gluten. A review of methods for the purification, identification and quantitation of wheat proteins to investigate coeliac disease is presented. Recent developments including amino acid sequencing and expression of wheat protein peptides in E. coli should permit characterization of the cereal peptide that exacerbates coeliac disease.
Ciclitira
P J
PJ
Division of Medicine, Rayne Institute, United Medical School, Guy's Hospital, London, UK.
Ellis
H J
HJ
D002446:Celiac Disease / Q000209:etiology*; D004044:Dietary Proteins / Q000009:adverse effects / Q000302:isolation & purification*; D006801:Humans; D010940:Plant Proteins / Q000009:adverse effects / Q000302:isolation & purification*; D014908:Triticum / Q000009:adverse effects*
D004044:Dietary Proteins; D010940:Plant Proteins