title: Citrobacter diversus and neonatal brain abscess.
abstract: A 23-day-old infant presented with apnea and was found to have Citrobacter diversus meningitis and brain abscess. The organism persisted in brain abscess fluid for over 4 weeks despite adequate antibiotic therapy. Cranial computed tomography demonstrated persistent radiolucencies in both frontal lobes, and midline shift, long after completion of antibiotic therapy. Effective therapy of C. diversus meningitis and brain abscess may require use of an antibiotic active within phagocytes, and judicious surgical drainage. A high prevalence of brain abscess mandates cranial computed tomography for any infant with C. diversus meningitis.
authors.affiliation: Myers-Black Section of Pediatric Infectious Diseases, Baylor College of Medicine and Texas Children's Hospital, Houston 77030.
authors.forename: M W
authors.initials: MW
authors.lastname: Kline
authors.forename: S L
authors.initials: SL
authors.lastname: Kaplan
mesh_terms: D001431:Bacteriological Techniques; D001922:Brain Abscess / Q000188:drug therapy / Q000382:microbiology*; D002701:Chloramphenicol / Q000627:therapeutic use; D002954:Citrobacter / Q000472:pathogenicity; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000382:microbiology*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008581:Meningitis / Q000382:microbiology; D009070:Moxalactam / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D002701:Chloramphenicol; D009070:Moxalactam