Sickle cell E hemoglobinopathy and pregnancy.
The incidence of E hemoglobinopathies has been increasing in the United States. This is the first known case report of hemoglobin S/E in pregnancy. Management was based on the similarities of the S/E and S/beta-thalassemia hemoglobinopathies, and included partial exchange transfusion. Complications included fetal distress, congenital hydrocephalus, and cleft lip and palate. It appears that S/E and E/beta-thalassemia hemoglobinopathies may entail increased perinatal risks, but that favorable pregnancy outcomes may be anticipated with homozygous hemoglobin E or hemoglobin E trait.
Ramahi
A J
AJ
Department of Obstetrics and Gynecology, Hutzel Hospital/Wayne State University, Detroit, Michigan.
Lewkow
L M
LM
Dombrowski
M P
MP
Bottoms
S F
SF
D000328:Adult; D000755:Anemia, Sickle Cell / Q000628:therapy; D005260:Female; D006446:Hemoglobin E; D006453:Hemoglobinopathies / Q000628:therapy; D006455:Hemoglobins, Abnormal; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy
D006455:Hemoglobins, Abnormal; D006446:Hemoglobin E