title: Effect of adjuvant reserpine treatment on catecholamine metabolism in schizophrenic patients under long-term neuroleptic treatment.
abstract: The clinical and biochemical effects of adjuvant reserpine treatment were investigated in 12 chronic schizophrenic patients on long-term neuroleptic medication. The global severity of the symptoms using the Brief Psychiatric Rating Scale did not change significantly in the whole group, however, a moderate decrease in positive symptoms (factors though disturbance, activation and hostile-suspiciousness) was observed for 5 patients. Cerebrospinal fluid (CSF) noradrenaline levels showed a consistent decrease, but other biochemical parameters (CSF dopamine metabolites, platelet MAO and serum dopamine-beta-hydroxylase activities) did not change significantly. The changes of clinical symptoms and biochemical parameters did not show any correlation.
authors.affiliation: National Institute for Nervous and Mental Diseases, Budapest, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Bagdy
authors.forename: A
authors.initials: A
authors.lastname: Perenyi
authors.forename: E
authors.initials: E
authors.lastname: Frecska
authors.forename: A
authors.initials: A
authors.lastname: Seregi
authors.forename: M I
authors.initials: MI
authors.lastname: Fekete
authors.forename: L
authors.initials: L
authors.lastname: Tothfalusi
authors.forename: K
authors.initials: K
authors.lastname: Magyar
authors.forename: A
authors.initials: A
authors.lastname: Bela
authors.forename: M
authors.initials: M
authors.lastname: Arato
mesh_terms: D000277:Adjuvants, Pharmaceutic; D000328:Adult; D002395:Catecholamines / Q000134:cerebrospinal fluid*; D004299:Dopamine beta-Hydroxylase / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood; D011388:Prolactin / Q000097:blood; D012110:Reserpine / Q000008:administration & dosage / Q000627:therapeutic use*; D012559:Schizophrenia / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000277:Adjuvants, Pharmaceutic; D002395:Catecholamines; D012110:Reserpine; D011388:Prolactin; D004299:Dopamine beta-Hydroxylase; D008995:Monoamine Oxidase