Pharmacological modulation of cold-induced pain in cutaneous leiomyomata.
In two patients with painful cutaneous leiomyomata, induction of pain by the application of an ice cube allowed assessment of a number of topical and systemic treatments aimed at reducing or preventing the pain. In one patient the alpha-adrenoceptor blocker, phenoxybenzamine alleviated cold-induced pain. In the second patient, topical 9% hyoscine hydrobromide (an anticholinergic agent) decreased pain induced by the ice cube, but was not helpful in reducing lesional pain due to cold weather.
Archer
C B
CB
St John's Hospital for Diseases of the Skin, Leicester Square, London, U.K.
Whittaker
S
S
Greaves
M W
MW
D000328:Adult; D003080:Cold Temperature / Q000009:adverse effects; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010643:Phenoxybenzamine / Q000627:therapeutic use; D012601:Scopolamine / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000503:physiopathology*
D010643:Phenoxybenzamine; D012601:Scopolamine