[Calcium regulation of muscle contraction: the molecular regulation mechanisms of contracility].
The role of calcium in muscle activation is described with particular emphasis on interactions occurring between the regulatory proteins troponin-C, troponin-I, actin and myosin. These interactions depend on calcium, but in turn they also influence the calcium binding to troponin-C. They may be affected by short "competitive" peptides whose sequences are similar to the amino-acid sequences on the protein-interaction sites. They may be also affected by certain drugs (cardiotonic calcium sensitizers) that influence the calcium sensitivity of myofilaments.
Rüegg
J C
JC
II. Physiologisches Institut der Universität, Heidelberg.
D000818:Animals; D002118:Calcium / Q000494:pharmacology / Q000502:physiology*; D009119:Muscle Contraction / Q000187:drug effects; D009124:Muscle Proteins / Q000502:physiology*
D009124:Muscle Proteins; D002118:Calcium
Calcium-Regulation der Muskelkontraktion. Die molekularen Regulations-mechanismen der Kontraktilität.