Flupirtine in the treatment of post-operative pain.
Flupirtine maleate (referred to throughout this paper as flupirtine) capsules 100 mg and suppositories 150 mg were found to be safe and efficacious in several randomized, controlled, double-blind parallel group clinical trials. 586 patients (40 children) suffering from post-operative pain were treated. Flupirtine was significantly more effective than placebo and as well tolerated. It was as effective and acceptable as pentazocine and dihydrocodeine for the treatment of post-operative pain, but offered advantages in terms of fewer central nervous system side effects. It was at least as effective as the non-narcotics metamizole, paracetamol and naproxen.
Riethmüller-Winzen
H
H
Homburg Degussa Pharma Gruppe, Frankfurt am Main, FRG.
D000328:Adult; D000631:Aminopyridines / Q000627:therapeutic use*; D000700:Analgesics / Q000627:therapeutic use*; D002648:Child; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D010149:Postoperative Pain / Q000188:drug therapy*; D011897:Random Allocation
D000631:Aminopyridines; D000700:Analgesics; C034161:flupirtine