In vitro assessment of anti-Leishmania immunity of man acquired with a vaccine.
Monocytes, obtained from a human volunteer immunized with a Leishmania infantum-derived vaccine, when cultured in vitro displayed a strong parasiticidal activity against L. major promastigotes. In addition, immune serum conferred leishmanicidal activities to monocytes of normal, unexposed donors, and to murine macrophages.
Vouldoukis
I
I
Laboratoire de Parasitologie Expérimentale, Faculté de Médecine Pitié-Salpêtriére, Paris, France.
Ogunkolade
B W
BW
Frommel
D
D
Alier
N
N
Monjour
L
L
D000818:Animals; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007114:Immunization; D007891:Leishmania / Q000276:immunology*; D007893:Leishmania donovani / Q000276:immunology*; D007895:Leishmania tropica / Q000276:immunology; D007896:Leishmaniasis / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009000:Monocytes / Q000276:immunology; D010587:Phagocytosis; D014612:Vaccines / Q000276:immunology*
D007106:Immune Sera; D014612:Vaccines