A new method for early detection of renal allograft rejection. Gel high-performance chromatography of urinary IgM.
We developed a new device utilizing high-performance chromatography to measure urinary IgM protein in renal transplant recipients. With this device we were able to obtain a reliable result in less than 2 h, requiring much less time than using the conventional method. Urinary IgM was found in 22 of 23 posttransplantation patients (96%) during acute rejection. An increase in urinary IgM excretion was noted 2-3 days before the appearance of clinical signs of acute rejection.
Yamada
Y
Y
Department of Urology, Yamanashi Medical College, Japan.
Ueno
A
A
Otsubo
O
O
Inou
T
T
Takai
N
N
D000328:Adult; D002850:Chromatography, Gel / Q000295:instrumentation*; D006084:Graft Rejection / Q000187:drug effects; D006801:Humans; D007075:Immunoglobulin M / Q000652:urine*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male
D007075:Immunoglobulin M; D007166:Immunosuppressive Agents