title: The relationship between exposure duration and sulfur dioxide-induced bronchoconstriction in asthmatic subjects.
abstract: The purpose of this study was to determine the shortest duration of exposure to 1.0 ppm sulfur dioxide (SO2) sufficient to induce bronchoconstriction significantly greater than that observed with exposure to clean air (CA) in exercising SO2-sensitive asthmatics. Asymptomatic, nonmedicated, male asthmatics (n = 12) with airway hyperresponsiveness to both methacholine and SO2 were exposed in a chamber (20 degrees C, 40% relative humidity) for 0.0, 0.5, 1.0, 2.0 and 5.0 min to both CA and 1.0 ppm SO2 on separate days (10 exposures). Just prior to each exposure, subjects walked on a treadmill in CA for 5 min at a predetermined speed/elevation to elicit a target ventilation of about 40 L/min, i.e., a brisk pace up a slight incline. After this walk, subjects rapidly entered an adjoining exposure chamber containing either CA or SO2 and immediately walked at the same speed/elevation for the specified exposure duration. Subjects then rapidly exited the chamber. Specific airway resistance (SRaw) and ratings of respiratory symptoms associated with asthma [shortness of breath/chest discomfort (SB/CD) and wheezing (WHZ)] were measured prior to any exercise and following each exposure. Postexposure SRaw and symptom ratings increased with increased exposure duration in SO2; postexposure SRaw also was increased with increased exposure duration in CA but to a lesser extent. After adjusting for the CA response, significantly greater SO2-induced bronchoconstriction was observed for the 2.0 and 5.0 min exposures as indicated by substantially greater increases in SRaw and substantially higher ratings of respiratory symptoms. The authors conclude that with the above exposure conditions, on average, SO2-sensitive asthmatics exhibit significant bronchoconstriction at exposure durations of 2.0 min or more.
authors.affiliation: Clinical Research Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.
authors.forename: D H
authors.initials: DH
authors.lastname: Horstman
authors.forename: E
authors.initials: E
authors.lastname: Seal
authors.forename: L J
authors.initials: LJ
authors.lastname: Folinsbee
authors.forename: P
authors.initials: P
authors.lastname: Ives
authors.forename: L J
authors.initials: LJ
authors.lastname: Roger
mesh_terms: D000328:Adult; D000403:Airway Resistance; D001249:Asthma / Q000503:physiopathology*; D001250:Asthma, Exercise-Induced / Q000503:physiopathology*; D001980:Bronchi / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D010991:Plethysmography; D013147:Spirometry; D013458:Sulfur Dioxide / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors
chemical_list: D013458:Sulfur Dioxide