Resistance to growth of the Moloney lymphoma YAC in semi-syngeneic graft recipients.
The growth of the Moloney-virus-induced lymphoma YAC was examined in its strain of origin, A, as well as in 6 AF1 hybrids, ALF1, AB6F1, ACBF1, AABYF1, AACAF1 and AASWF1. "Hybrid resistance", i.e., lower frequency of incidence of tumor takes compared to simultaneous A controls, was observed in all of the tested hybrids. The results with the H-2-congeneic hybrids AABYF1, AACAF1 and AASWF1 indicated that H-2 heterozygosity in itself was sufficient to exhibit hybrid resistance against YAC grafts. The A strain and its H-2 congeneic AABYF1, AACAF1 and AASWF1 hybrids all had similarly low activity in NK assays. Thus, the elevated resistance detected in these H-2 congeneic hybrids did not correlate with NK activity. The rejection capacity of the ALF1, AB6F1 and ACBF1 hybrids correlated to their relatively higher NK activity, when compared to the NK low AABYF1, AACAF1 and AASWF1 hybrids. However, consideration of quantitative differences in between the hybrids which expressed elevated NK activity (i.e., ALF1, AB6F1 and ACBF1) shows that the rejection capacity did not correlate with NK status. The hybrid with the strongest NK effect (ACBF1) was the least resistant to YAC growth (27% palpable tumors), and the hybrid with the weakest NK effect (ALF1) was the most resistant to YAC growth (7.2% palpable tumors).
Ahrlund-Richter
L
L
Department of Tumor Biology, Karolinska Instituet, Stockholm, Sweden.
Klein
E
E
D000818:Animals; D002455:Cell Division; D003433:Crosses, Genetic; D005838:Genotype; D008223:Lymphoma / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D051379:Mice; D008815:Mice, Inbred Strains; D008979:Moloney murine leukemia virus / Q000472:pathogenicity; D009368:Neoplasm Transplantation; D013045:Species Specificity; D014185:Transplantation, Isogeneic