NMR investigation of the copper(II)-carnosine complex in water solution.
The predominant species in water solution of excess carnosine and Cu2+ ions was characterized by measuring 13C and 1H spin-lattice and spin-spin relaxation rates. Four peptide molecules were calculated to be coordinated to the metal through the imidazole nitrogen. Evaluation of ion-proton distances demonstrated that metal complexation does not involve severe changes in conformation of the peptide.
Gaggelli
E
E
Department of Chemistry, University of Siena, Italy.
Basosi
R
R
Pogni
R
R
Valensin
G
G
D002336:Carnosine; D003300:Copper; D004151:Dipeptides; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D011487:Protein Conformation; D012996:Solutions
D004151:Dipeptides; D012996:Solutions; D003300:Copper; D002336:Carnosine