[Use of diazoxide in the studies of the effect of glucagon on the blood serum levels of glucose, free fatty acids and triglycerides in rabbits].
Diazoxide was used to prevent the high insulin secretion after glucagon administration to rabbits. Using of this benzothiadiazine allowed to investigate an effect of glucagon on the blood glucose, free fatty acids and triglycerides without raised insulin. The concentration of serum glucose was increased in all experiments (with or without diazoxide infusion), however both normoinsulinemic and hyperinsulinemic rabbits showed return to the control value in the end of experiments. In the case of FFA the high level of insulin was necessary to return their concentration to the control value. Glucagon alone had no effect on serum TG level.
Nowak
K W
KW
Katedra Fizjologii i Biochemii Zwierzat, Akademia Rolnicza w Poznaniu.
Nogowski
L
L
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003981:Diazoxide / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005934:Glucagon / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D011817:Rabbits / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D008055:Lipids; D014280:Triglycerides; D005934:Glucagon; D003981:Diazoxide
Zastosowanie diazoksydu w badaniach nad wpływem glukagonu na poziom glukozy, wolnych kwasów tłuszczowych i triglicerydów w surowicy krwi królików.