title: Legionella prosthetic-valve endocarditis.
abstract: Since 1982 seven patients at Stanford University Medical Center have been shown to have prosthetic-valve endocarditis caused by Legionella pneumophila or L. dumoffii. We studied the clinical features of legionella endocarditis at the time of diagnosis and performed a case-control study to analyze risk factors for the infection. All patients with endocarditis had a chronic course (3 to 19 months after surgery) of fever, night sweats, weight loss, and anemia, but no embolic events or immune-complex deposition disease. Five patients required surgical replacement of their infected prosthetic valves. The case-control study revealed that during the early postoperative period, patients who later contracted legionella endocarditis were more likely to have had symptoms and signs attributable to postcardiomyotomy syndrome than were patients who did not contract endocarditis (P less than 0.013). Examination of the legionella isolates by means of molecular techniques demonstrated that the Stanford L. pneumophila isolates were genotypically identical to isolates from the hospital drinking water. L. dumoffii isolates from patients with endocarditis were derived from a single strain apparently unique to this medical center. We conclude that legionella infection was nosocomially acquired in the perioperative period. These cases demonstrate an expanding spectrum of illness caused by legionella species and emphasize the need to consider legionella as a cause of "culture-negative" endocarditis.
authors.affiliation: Department of Medicine, Stanford University, Calif.
authors.forename: L S
authors.initials: LS
authors.lastname: Tompkins
authors.forename: B J
authors.initials: BJ
authors.lastname: Roessler
authors.forename: S C
authors.initials: SC
authors.lastname: Redd
authors.forename: L E
authors.initials: LE
authors.lastname: Markowitz
authors.forename: M L
authors.initials: ML
authors.lastname: Cohen
mesh_terms: D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000209:etiology*; D006350:Heart Valve Prosthesis; D006801:Humans; D007875:Legionella / Q000302:isolation & purification; D007876:Legionellosis / Q000175:diagnosis / Q000209:etiology*; D007877:Legionnaires' Disease / Q000209:etiology; D008875:Middle Aged; D012307:Risk Factors; D014871:Water Microbiology