Cytotoxic effects of a leukocidin from Fusobacterium necrophorum on bovine hepatic cells.
Cytotoxic effects of a leukocidin from Fusobacterium necrophorum were demonstrated on bovine hepatic cells. The cytotoxic response was dose-dependent and could be inhibited by homologous antiserum. Scanning electron microscopy revealed damaged hepatic cell surface. These findings indicated a pathogenic role of the leukocidin in F. necrophorum infections.
Ishii
T
T
Department of Veterinary Microbiology and Hygiene, Faculty of Agriculture, Yamaguchi University, Japan.
Kanoe
M
M
Inoue
T
T
Kai
K
K
Blobel
H
H
D000818:Animals; D002417:Cattle; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D002470:Cell Survival / Q000187:drug effects; D005674:Fusobacterium Infections / Q000473:pathology; D005675:Fusobacterium necrophorum / Q000032:analysis*; D066298:In Vitro Techniques; D007956:Leukocidins / Q000302:isolation & purification / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D009336:Necrosis
D007956:Leukocidins