title: Earliest renin containing cell differentiation during ontogenesis in the rat. An immunocytochemical study.
abstract: The differentiation of renin containing cells was studied by immunocytochemistry in normal rat fetuses by the use of highly specific renin, angiotensin I and II antisera. Renin synthesizing cells were detectable as early as the 15th day of gestation outside the nephrogen territories within the walls of mesonephrotic-gonadic and renal arteries. Intrarenal differentiation began at the 17th day and progressed along the intrarenal arterial tree. AII immunostaining appeared concomitantly in the renin containing cells and developed considerably during ontogenesis, suggesting intracellular biosynthesis. It can be suggested that in the fetus newly synthesized AII may contribute to the early systemic and renal blood pressure regulation.
authors.affiliation: Laboratoire d'Histologie-Embryologie, Faculté de Médecine, Vandoeuvre-les-Nancy, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Richoux
authors.forename: S
authors.initials: S
authors.lastname: Amsaguine
authors.forename: G
authors.initials: G
authors.lastname: Grignon
authors.forename: J
authors.initials: J
authors.lastname: Bouhnik
authors.forename: J
authors.initials: J
authors.lastname: Menard
authors.forename: P
authors.initials: P
authors.lastname: Corvol
mesh_terms: D000804:Angiotensin II / Q000032:analysis; D000818:Animals; D001158:Arteries / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D002454:Cell Differentiation; D005865:Gestational Age; D006651:Histocytochemistry; D007124:Immunoenzyme Techniques; D007668:Kidney / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000032:analysis* / Q000096:biosynthesis
chemical_list: D000804:Angiotensin II; D012083:Renin