title: The effect of induced hypotension and tissue trauma on renal function in scoliosis surgery.
abstract: The surgical correction of scoliosis in adolescents involves considerable trauma to bone and muscle which, together with hypotensive anaesthesia, might be expected to compromise renal function. Our recent observation of acute renal failure in two such patients prompted a prospective study of renal function following 52 operations in 43 patients. Despite hypotension, blood loss, muscle damage and evidence of fat embolism, renal function was unaltered in all patients, and there was no impairment of spinal cord function. Careful attention was paid to the maintenance of circulating volume which is essential to protect renal perfusion.
authors.affiliation: Renal Unit, St Peter's Hospital, London, England.
authors.forename: P B
authors.initials: PB
authors.lastname: Rylance
authors.forename: F
authors.initials: F
authors.lastname: Carli
authors.forename: S E
authors.initials: SE
authors.lastname: McArthur
authors.forename: A O
authors.initials: AO
authors.lastname: Ransford
authors.forename: M A
authors.initials: MA
authors.lastname: Mansell
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007023:Hypotension, Controlled / Q000009:adverse effects*; D007432:Intraoperative Period; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D011183:Postoperative Complications; D011446:Prospective Studies; D012600:Scoliosis / Q000378:metabolism / Q000601:surgery*; D012964:Sodium / Q000378:metabolism
chemical_list: D012964:Sodium; D003404:Creatinine