title: Anti-inflammatory activity of superoxide dismutases: inhibition of carrageenan induced edema in rats.
abstract: Eighteen different superoxide dismutases from procaryote, plant, fish, bird and mammalian species have been tested for anti-inflammatory activity in the rat paw pad carrageenan-induced inflammation model. Very large differences in activity are observed. Homologous rat Cu-SOD is not active and indeed shows slight pro-inflammatory activity. The different SODs have different iso-electric values, different metals (Cu, Mn or Fe) at the active centre, different molecular weights and different circulation lifetimes. Biological activity is a function of amino acid sequence rather than of such secondary parameters.
authors.affiliation: Service de Pharmacologie, Faculté de Pharmacie, Marseille, France.
authors.forename: G
authors.initials: G
authors.lastname: Jadot
authors.forename: A M
authors.initials: AM
authors.lastname: Michelson
authors.forename: K
authors.initials: K
authors.lastname: Puget
mesh_terms: D000818:Animals; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D004926:Escherichia coli / Q000201:enzymology; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D002351:Carrageenan; D013482:Superoxide Dismutase