Effects of N,N,N',N'-ethylenediaminetetramethylene phosphonic acid on cortical bone remodeling in the adult dog.
Phosphonic acids are of interest because of their potential usefulness in the treatment of disorders of bone and mineral metabolism, as a treatment for dental calculus, and as skeletal imaging agents. The effects of oral doses of N,N,N',N'-ethylenediaminetetramethylene phosphonic acid (EDITEMPA) on cortical bone remodeling and histology of adult dogs were determined. After treatment for 3 and 6 months, there were dose-related changes observed in cortical bone as measured using histomorphometric methods. With higher doses, EDITEMPA treatment resulted in the accumulation of osteoid due to impaired or delayed mineralization of bone. There was an increased mineralized and osseous tissue porosity suggesting an early increase in bone resorption perhaps due to an increased activation of bone remodeling.
Jee
W S
WS
Division of Radiobiology, School of Medicine, University of Utah, Salt Lake City 84112.
Miller
S C
SC
Li
X J
XJ
DeSalva
S
S
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects; D001842:Bone and Bones / Q000378:metabolism; D004285:Dogs; D005260:Female; D008903:Minerals / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010012:Osteogenesis / Q000187:drug effects*
D008903:Minerals; D009943:Organophosphorus Compounds; C018940:(ethylenedinitrilo)-tetramethylenephosphonic acid