title: Intracerebral hemorrhage in a primate model: effect on regional cerebral blood flow.
abstract: The dynamic changes in regional cerebral blood flow (rCBF), induced by a developing intracerebral hematoma, were studied in eight anesthetized monkeys. Hematomas were generated by allowing femoral arterial blood to enter the caudate nucleus via a stereotactically implanted needle. Intracranial pressure peaked at 51 +/- 8 mmHg at 3 minutes after the ictus, and remained high throughout the 3-hour procedure. Cerebral blood flow was significantly reduced in all brain regions for 1 hour after the ictus. The lowest rCBF values were recorded in the immediate clot penumbra and were below threshold levels for ischemic neuronal damage for 90 minutes after the hemorrhage.
authors.affiliation: Department of Neurosurgery, Wentworth Hospital, Durban, South Africa.
authors.forename: R
authors.initials: R
authors.lastname: Bullock
authors.forename: J
authors.initials: J
authors.lastname: Brock-Utne
authors.forename: J
authors.initials: J
authors.lastname: van Dellen
authors.forename: G
authors.initials: G
authors.lastname: Blake
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D002522:Chlorocebus aethiops; D006406:Hematoma / Q000473:pathology; D007427:Intracranial Pressure; D013046:Specific Gravity