Types of adrenocorticoids and their effect on organophosphorus-induced delayed neuropathy in chickens.
The present study examined the effects of a glucocorticoid and a mineralocorticoid on organophosphorus-induced delayed neuropathy (OPIDN) as previous investigations have indicated that an endogenous steroid with both properties could alter this syndrome in chickens. The glucocorticoid triamcinolone and the mineralocorticoid deoxycorticosterone were provided in the diet beginning 1 day before and continuing 10 days after triortho-tolyl phosphate (TOTP, 360 mg/kg po), phenyl saligenin phosphate (PSP, 2.5 mg/kg im), and diisopropyl phosphorofluoridate (DFP, 1 mg/kg sc). In a manner similar to that seen with corticosterone, a low concentration (0.1 ppm) of triamcinolone reduced and a high concentration (10 ppm) exacerbated clinical signs. Concentrations of deoxycorticosterone under 80 ppm also partially delayed or ameliorated ataxia induced by TOTP, PSP, and DFP, but a combination of 0.1 ppm triamcinolone and 80 ppm deoxycorticosterone was not more effective than triamcinolone alone. Peripheral nerve damage was noted in all chickens given organophosphorus compounds, whether or not they had been given corticoids. Both steroids induced hydroxylase activity, but effects on most other enzyme systems examined were unremarkable. High concentrations of triamcinolone (10 ppm) could, however, also reduce liver cytochrome P450 levels and liver cholinesterase activity. Exacerbation of OPIDN was most notable in chickens under highest stress, as indicated by elevated heterophil-to-lymphocyte ratios. The clinical, pathological, biochemical, and hematological indices of exposure to adrenocorticoids and agents inducing OPIDN in chickens were, therefore, similar for both a synthetic glucocorticoid and the endogenous steroid corticosterone.
Ehrich
M
M
Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg 24061.
Jortner
B S
BS
Gross
W B
WB
D000818:Animals; D001259:Ataxia / Q000139:chemically induced / Q000517:prevention & control*; D002645:Chickens; D003900:Desoxycorticosterone / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D013979:Tibial Nerve / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D014221:Triamcinolone / Q000494:pharmacology*
D009943:Organophosphorus Compounds; D014221:Triamcinolone; D003900:Desoxycorticosterone