A gas chromatographic/mass spectrometric screening, confirmation, and quantification method for estrogenic compounds.
A method is described for the screening, quantification and confirmation of a variety of estronenic substances in animal tissues. A solid-phase extraction technique combined with a liquid/liquid extraction allows for rapid sample preparation and high throughput for the following compounds in bovine liver, muscle and kidney: diethylstilbestrol, dienestrol, hexestrol, zeranol, taleranol, zearalanone, zearalenone, zearalenol, estradiol and estriol. Gas chromatography/mass spectrometry and selected ion monitoring is used for the determination with detection limits ranging from 50 to 150 ppt.
Covey
T R
TR
Equine Drug Testing and Toxicology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14850.
Silvestre
D
D
Hoffman
M K
MK
Henion
J D
JD
D000818:Animals; D002417:Cattle; D004350:Drug Residues / Q000032:analysis*; D004967:Estrogens / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D008099:Liver / Q000032:analysis; D008460:Meat / Q000032:analysis*
D004967:Estrogens