Studies on bacteriophage penetration in patients subjected to phage therapy.
Two healthy volunteers and 56 patients with suppurative bacterial infections were tested for penetration of oral administered bacteriophage to the blood circulation system and urinary tract. In the blood and urine samples collected from patients before phage therapy application, no presence of "wild phages" was confirmed. Examination performed on the 10th day of phage therapy revealed the presence of bacteriophages in 47 of 56 blood samples tested; positive result of examination was obtained in 9 cases of 26 urine samples.
Weber-Dabrowska
B
B
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw.
Dabrowski
M
M
Slopek
S
S
D000284:Administration, Oral; D000328:Adult; D001424:Bacterial Infections / Q000382:microbiology / Q000628:therapy*; D001435:Bacteriophages / Q000032:analysis*; D001769:Blood / Q000382:microbiology*; D004927:Escherichia coli Infections / Q000276:immunology / Q000628:therapy; D006801:Humans; D007710:Klebsiella Infections / Q000276:immunology / Q000628:therapy; D011552:Pseudomonas Infections / Q000276:immunology / Q000628:therapy; D013203:Staphylococcal Infections / Q000276:immunology / Q000628:therapy; D014556:Urine / Q000382:microbiology*; D010948:Viral Plaque Assay