Effect of cholinergic drugs on outflow facility after ciliary ganglionectomy.
In cynomolgus monkeys, resting total outflow facility was unaltered 1 and 6 or more months after ciliary ganglionectomy (CG) or postganglionic ciliary neurectomy (PCN). Intraocular pressure (IOP) was decreased in the denervated eye 1 week and 1 month after surgery, but returned to normal after 6 or more months. Although baseline facilities were comparable in CG/PCN and fellow control eyes 6 or more months after surgery, even maximal intracameral doses of pilocarpine did not increase outflow facility in previously denervated eyes, while a normal facility increase occurred in fellow control eyes. However, both previously denervated and fellow control eyes exhibited a large facility increase to both submaximal and greater than maximal intracameral doses of eserine.
Erickson-Lamy
K A
KA
Howe Laboratory, Massachusetts Eye and Ear Infirmary, Boston 02114.
Kaufman
P L
PL
D000818:Animals; D002924:Ciliary Body / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D005726:Ganglia, Parasympathetic / Q000601:surgery*; D008252:Macaca fascicularis; D010830:Physostigmine / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology*
D010862:Pilocarpine; D010830:Physostigmine