title: [Recurrent thrombosis of an aortic valve prosthesis in a pregnant woman. Treatment with urokinase].
abstract: A 36 year old woman developed two thromboses on aortic valve prosthesis. The first thrombus at the 14th week of pregnancy was treated with urokinase (2,000 U/kg/h) plus heparin (700-1,000 U/h) over 24 hours and normal wing kinetics were obtained. The second thrombus developed at the 36 th week of pregnancy when the patient was receiving calciparin, and only transient improvement was obtained with similar doses of urokinase hourly over 72 hours. Progressive worsening resulted in higher doses (4,000 U/kg/h) being given without heparin and the thrombus then resolved. The use of urokinase for the first time in this indication allowed therefore, on two occasions and without hemorrhagic complications the cure of this recurrent thrombosis on aortic prosthesis, and the birth, by caesarean, of a healthy baby.
authors.affiliation: Service de Cardiologie, Hôpital cardiologique, Pessac.
authors.forename: M
authors.initials: M
authors.lastname: Jimenez
authors.forename: C
authors.initials: C
authors.lastname: Vergnes
authors.forename: L
authors.initials: L
authors.lastname: Brottier
authors.forename: J L
authors.initials: JL
authors.lastname: Dequeker
authors.forename: M A
authors.initials: MA
authors.lastname: Billes
authors.forename: M F
authors.initials: MF
authors.lastname: Lorient Roudaut
authors.forename: A
authors.initials: A
authors.lastname: Choussat
authors.forename: M R
authors.initials: MR
authors.lastname: Boisseau
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000601:surgery*; D004359:Drug Therapy, Combination; D005260:Female; D006350:Heart Valve Prosthesis; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011261:Pregnancy Trimester, First; D012008:Recurrence; D013927:Thrombosis / Q000188:drug therapy*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D006493:Heparin; D014568:Urokinase-Type Plasminogen Activator
vernacular_title: Thrombose récidivante d'une prothèse valvulaire aortique chez une femme enceinte. Traitement par urokinase.