title: Massive transfusion.
abstract: Massive transfusion is a potentially serious problem associated with a number of complications, including changes in coagulation factor and platelet concentration, nonmechanical bleeding, hypothermia, pulmonary dysfunction, hypokalemia and hyperkalemia, hypocalcemia, hypomagnesemia, acidosis and alkalosis, immune suppression, blood transfusion reactions, and transmission of infectious diseases. The pathophysiology and management of massive transfusion are reviewed in this article.
authors.affiliation: Department of Surgery, University of North Carolina, Chapel Hill School of Medicine.
authors.forename: R
authors.initials: R
authors.lastname: Rutledge
authors.forename: G F
authors.initials: GF
authors.lastname: Sheldon
authors.forename: M L
authors.initials: ML
authors.lastname: Collins
mesh_terms: D001778:Blood Coagulation Disorders / Q000209:etiology; D001779:Blood Coagulation Factors / Q000502:physiology; D001791:Blood Platelet Disorders / Q000209:etiology; D001803:Blood Transfusion / Q000379:methods; D006801:Humans; D065227:Transfusion Reaction
chemical_list: D001779:Blood Coagulation Factors