Chronic myelomonocytic leukemia terminating as malignant histiocytosis.
A patient with a 3.5 year history of chronic myelomonocytic leukemia who transformed to malignant histiocytosis is reported. The terminal event was characterized by fever, hepatosplenomegaly, thrombocytopenia, and a leukemic blood picture. The pathogenesis of this terminal transformation and proposed future studies are discussed.
Doll
D C
DC
Veterans Administration Medical Center, Phoenix, Arizona 85012.
Grogan
T M
TM
Greenberg
B R
BR
D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D054747:Histiocytic Sarcoma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male