title: Pancreatic abscess: results of prolonged irrigation of the pancreatic bed after surgery.
abstract: The mortality from pancreatic abscess may approach 70 per cent and the survivors often require repeated operations to debride the pancreas and to drain recurrent abscesses. We report the results of prolonged irrigation of the pancreatic bed after surgical débridement in 11 patients. Surgery was performed at an average of 17 days (range 8-25 days) after the onset of symptoms. The pancreatic slough was thoroughly debrided and 2-6 large drains were placed in the pancreatic bed. Irrigation with saline or Diaflex solution (2-6 l/day) was started after 2 days and continued for a mean of 25 days (range 5-54 days). There were three deaths (27.3 per cent) after surgery: one of these patients required reoperation and packing for massive postoperative haemorrhage and all three had some evidence of persisting sepsis at autopsy. Prolonged irrigation of the pancreatic bed after surgical débridement may reduce mortality and the need for repeated drainage procedures in patients with pancreatic abscess, but the detection and treatment of persisting sepsis remains the major problem.
authors.affiliation: Bristol Royal Infirmary, UK.
authors.forename: M L
authors.initials: ML
authors.lastname: Nicholson
authors.forename: N J
authors.initials: NJ
authors.lastname: Mortensen
authors.forename: H J
authors.initials: HJ
authors.lastname: Espiner
mesh_terms: D000038:Abscess / Q000382:microbiology / Q000601:surgery / Q000628:therapy*; D000208:Acute Disease; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000382:microbiology / Q000601:surgery / Q000628:therapy*; D011183:Postoperative Complications; D007507:Therapeutic Irrigation