Mammary carcinoma developing after radiotherapy and chemotherapy for Hodgkin's disease.
Two patients developed breast cancer after treatment of Hodgkin's disease. Both had received mediastinal irradiation 13 to 15 years, respectively, before the diagnosis of breast carcinoma. One patient had synchronous bilateral breast cancer when the diagnosis was made. Discussed is the risk of mammary carcinoma as a second malignant neoplasm in patients treated for Hodgkin's disease.
Janjan
N A
NA
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee 53226.
Wilson
J F
JF
Gillin
M
M
Anderson
T
T
Greenberg
M
M
Schewe
K
K
Cox
J D
JD
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D001943:Breast Neoplasms / Q000209:etiology*; D002277:Carcinoma / Q000209:etiology*; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy*; D006801:Humans; D008466:Mechlorethamine / Q000008:administration & dosage; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D011241:Prednisone