title: Primary T-cell lymphoma of the thyroid.
abstract: A rare case of non-Hodgkin's malignant T-cell lymphoma of the thyroid in a 79-year-old woman is reported. Light microscopically, the tumor showed diffuse proliferation of lymphoid cells, revealing prominent nuclear irregularity and occasional multilobulated nuclei, and was diagnosed as a diffuse lymphoma of medium-sized cell type. Electron microscopically, the tumor cells were seen to possess irregularly indented nuclei. Immunologic surface marker studies showed that the lymphoma cells were positive for T-lymphocyte-lineage antigens, OKT4 and OKT11, and did not react with B-lymphocyte-associated antigens. These findings indicated that the lymphoma had a T-cell phenotype.
authors.affiliation: Department of Pediatrics, Kanazawa University Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mizukami
authors.forename: F
authors.initials: F
authors.lastname: Matsubara
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: S
authors.initials: S
authors.lastname: Terahata
authors.forename: N
authors.initials: N
authors.lastname: Ikuta
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: A
authors.initials: A
authors.lastname: Ooi
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D013964:Thyroid Neoplasms / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure