title: [Endothelialization of central isolated leukomata adhaerentes].
abstract: Among 820 eyes enucleated between 1980 and 1984 and examined histologically there were 132 globes with central corneal-perforations. In ten of these there was a leukoma adherens not in contact with the anterior chamber angle. In all cases it was endothelialized with formation of a new basal lamina. The mean interval between trauma and enucleation of these ten eyes was 22.6 +/- 16.7 years (0.5-52 years), the mean age of the patients at the time of enucleation 50.7 +/- 22.4 years (15-78 years). Common to all these eyes and therefore of possible pathogenetic importance were: suitable tissue in contact with the corneal endothelium; traumatization of the endothelium and other intraocular structures; intraocular inflammation. The tissue which was pathologically changed and adherent to the cornea served as a "scaffold" for the endothelialization. Healing of the wound caused cell migration and proliferation and, together with intraocular inflammation, secretion of growth factors.
authors.affiliation: Augenklinik mit Poliklinik der Universität Erlangen-Nürnberg.
authors.forename: J B
authors.initials: JB
authors.lastname: Jonas
authors.forename: Z
authors.initials: Z
authors.lastname: Zágorski
authors.forename: H E
authors.initials: HE
authors.lastname: Völcker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000867:Anterior Chamber / Q000473:pathology; D001485:Basement Membrane / Q000473:pathology; D002921:Cicatrix / Q000473:pathology; D065306:Corneal Injuries; D004728:Endothelium, Corneal / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D014950:Wounds, Penetrating / Q000473:pathology*
vernacular_title: Endothelisierung zentraler isolierter Leucomata adhaerentes.