title: Monoamine neurotransmitters in the evolution of infarction in ischemic striatum: morphologic correlation.
abstract: Evolution of infarction following cerebral ischemia is a delayed process, with spongiform degeneration of the neuropil occurring 6 to 8 hours after onset of ischemia. The brains of gerbils with stroke following unilateral carotid artery ligation were examined for catecholamine-derived fluorescence (CADF) by the Falck-Hillarp technique to study the relationship of catecholamine (CA) metabolism with damage to the neuropil. CADF could still be identified in the striatum for up to 16 hours after stroke and there appeared to be spongiform degeneration of the neuropil in relation to accumulations of CADF at 7 and 16 hours after stroke. Pretreatment of gerbils with a-methyl-p-tyrosine 400 mg/kg 6 hours prior to carotid ligation depleted the striatum of CADF until 16 hours after stroke and appeared to reduce the spongiform degeneration of the neuropil, though it did not affect ischemic degeneration of neuronal cell bodies. The continued presence of CADF in the striatum for up to 16 hours after stroke supports the previously reported findings that CA nerve terminals are still functional for 8 hours after stroke and that CA metabolism continues even though levels of CA are reduced immediately after onset of ischemia due to carotid artery ligation.
authors.affiliation: Department of Neurology, Mount Sinai School of Medicine, New York, New York.
authors.forename: J
authors.initials: J
authors.lastname: Weinberger
authors.forename: J
authors.initials: J
authors.lastname: Nieves-Rosa
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002545:Brain Ischemia / Q000503:physiopathology*; D002395:Catecholamines / Q000378:metabolism*; D002544:Cerebral Infarction / Q000473:pathology / Q000503:physiopathology*; D002561:Cerebrovascular Disorders / Q000503:physiopathology*; D005849:Gerbillinae; D008297:Male; D008856:Microscopy, Fluorescence
chemical_list: D002395:Catecholamines