Ketanserin antagonises the anorectic effect of DL-fenfluramine in the rat.
To determine the role played by 5-HT2 receptors in the anorectic action of DL-fenfluramine, the ability of the selective 5-HT2 receptor antagonist ketanserin to block the reduction in food intake produced by this drug was investigated in non-deprived rats. Ketanserin (1 and 2.5 mg/kg i.p.) produced a dose-dependent antagonism of the anorectic effect of DL-fenfluramine (3 mg/kg i.p.). Prazosin (1 mg/kg i.p.) did not antagonise this effect. It is concluded that the anorectic actions of DL-fenfluramine are mediated via 5-HT2 receptors.
Hewson
G
G
Parke-Davis Research Unit, Addenbrookes Hospital Site, Cambridge, U.K.
Leighton
G E
GE
Hill
R G
RG
Hughes
J
J
D000818:Animals; D000855:Anorexia / Q000188:drug therapy; D005277:Fenfluramine / Q000037:antagonists & inhibitors*; D007650:Ketanserin / Q000494:pharmacology*; D008297:Male; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects
D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin; D005277:Fenfluramine; D007650:Ketanserin; D011224:Prazosin