Prevention of contraction of patched intestinal defects.
Neomucosal growth on a serosal patch might increase intestinal surface area in the short-bowel syndrome but is limited by contraction of the patched defect. Our aim was to reduce contraction by mechanical or pharmacologic means. Ileal defects (2 x 5 cm) were patched with colon serosa in 14 rabbits. Group 1 (n = 5) had a plastic splint sutured to the defect edge. Group 2 (n = 4) received hydrocortisone acetate and vitamin A. Group 3 (n = 5) was the control group. Four weeks after patching there was significantly less contraction in groups 1 and 2 compared with group 3 (72.3% +/- 5.6% and 50.0% +/- 5.8% vs 31.9% +/- 1.8% initial defect size). Epithelial coverage of the defect was greater in groups 1 and 3 than in group 2. Disaccharidase activity of neomucosa and surrounding mucosa was significantly decreased in the steroid-treated rabbits. Contraction of a serosal patch can be reduced by mechanical and pharmacologic measures that may enhance the clinical applicability of this technique.
Thompson
J S
JS
Omaha Veterans Administration Hospital, NE.
Hollingsed
T C
TC
Saxena
S K
SK
D000818:Animals; D003286:Contracture / Q000517:prevention & control*; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000627:therapeutic use; D007082:Ileum / Q000503:physiopathology / Q000601:surgery*; D007413:Intestinal Mucosa / Q000254:growth & development; D008297:Male; D011817:Rabbits; D013165:Splints
C021650:hydrocortisone acetate; D006854:Hydrocortisone