Inhibition of rabies virus infection by a soluble membrane fraction from the rat central nervous system.
This paper describes the inhibitory effect of a normal rat brain solubilized membrane preparation (RBSM-liposomes) on rabies virus infection. Rabies virus was incubated with RBSM-liposomes or their separated components (proteins, phospholipids, gangliosides) before infection of CER or neuroblastoma cells. In addition, both RBSM-liposomes and target cells were treated with enzymes prior to the infection step. All these experimental procedures showed that the active components were mainly lipids.
Conti
C
C
Institut Pasteur, Paris, France.
Hauttecoeur
B
B
Morelec
M J
MJ
Bizzini
B
B
Orsi
N
N
Tsiang
H
H
D000818:Animals; D001921:Brain / Q000382:microbiology*; D002462:Cell Membrane / Q000502:physiology*; D005732:Gangliosides / Q000502:physiology; D066298:In Vitro Techniques; D008081:Liposomes; D008563:Membrane Lipids / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D010743:Phospholipids / Q000502:physiology; D011818:Rabies / Q000503:physiopathology*; D051381:Rats; D011991:Receptors, Virus / Q000502:physiology*; D013347:Subcellular Fractions
D005732:Gangliosides; D008081:Liposomes; D008563:Membrane Lipids; D008565:Membrane Proteins; D010743:Phospholipids; D011991:Receptors, Virus