The value of indium-labelled leucocytes in clinical practice.
Following intravenous injection, autologous 111In labelled-leucocytes migrate to sites of inflammation, where they can be imaged with the gamma camera. The principle underlining the labelling technique is exposure of a population of leucocytes or purified granulocytes to a lipophilic 111In complex, such as 111In oxine or 111In tropolonate. As a result of cell activation, the in vitro manipulation to which the leucocytes are subjected modifies their biodistribution early after re-injection. Separation and labelling in plasma-enriched media, however, limits this activation and promotes early migration into inflammatory foci.
Peters
A M
AM
Royal Postgraduate Medical School, London.
Saverymuttu
S H
SH
D006801:Humans; D007205:Indium Radioisotopes; D007249:Inflammation / Q000000981:diagnostic imaging*; D007962:Leukocytes / Q000276:immunology*; D011877:Radionuclide Imaging
D007205:Indium Radioisotopes