title: Effect of cholinergic drugs on outflow facility after ciliary ganglionectomy.
abstract: In cynomolgus monkeys, resting total outflow facility was unaltered 1 and 6 or more months after ciliary ganglionectomy (CG) or postganglionic ciliary neurectomy (PCN). Intraocular pressure (IOP) was decreased in the denervated eye 1 week and 1 month after surgery, but returned to normal after 6 or more months. Although baseline facilities were comparable in CG/PCN and fellow control eyes 6 or more months after surgery, even maximal intracameral doses of pilocarpine did not increase outflow facility in previously denervated eyes, while a normal facility increase occurred in fellow control eyes. However, both previously denervated and fellow control eyes exhibited a large facility increase to both submaximal and greater than maximal intracameral doses of eserine.
authors.affiliation: Howe Laboratory, Massachusetts Eye and Ear Infirmary, Boston 02114.
authors.forename: K A
authors.initials: KA
authors.lastname: Erickson-Lamy
authors.forename: P L
authors.initials: PL
authors.lastname: Kaufman
mesh_terms: D000818:Animals; D002924:Ciliary Body / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D005726:Ganglia, Parasympathetic / Q000601:surgery*; D008252:Macaca fascicularis; D010830:Physostigmine / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology*
chemical_list: D010862:Pilocarpine; D010830:Physostigmine