Lack of efficacy of phosphatidylcholine in ataxias.
We gave phosphatidylcholine orally at a daily dosage of 9 grams for 4 years to 20 subjects with Friedreich's ataxia (FA) and 24 with olivopontocerebellar atrophy (OPCA). There was no clinical improvement during the follow-up compared with 12 ataxic patients (six FA and six OPCA) who did not receive any treatment. A 6-month trial at a double dose did not have any significant effect. This study indicates that phosphatidylcholine does not change the natural course of ataxias.
Sorbi
S
S
Department of Neurology, University of Florence, Italy.
Piacentini
S
S
Marini
P
P
De Scisciolo
G
G
Amantini
A
A
Amaducci
L
L
D001259:Ataxia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D009849:Olivopontocerebellar Atrophies / Q000188:drug therapy; D010713:Phosphatidylcholines / Q000627:therapeutic use*
D010713:Phosphatidylcholines