Tuftsin stimulates growth of HL60 cells.
Many functions of monocyte/macrophage and granulocyte are activated by tuftsin; principally phagocytosis, motility, immunogenic stimulation, antibacterial and antineoplastic activities. Here it is shown that tuftsin stimulates HL60 growth to twice the control rate. The uptake of [3H]uridine and [3H]leucine in a pulse of 30 min was also double that of the control. The uptake of thymidine was not stimulated.
Bump
N J
NJ
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.
Najjar
V A
VA
D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004261:DNA Replication; D004273:DNA, Neoplasm / Q000096:biosynthesis; D006801:Humans; D007700:Kinetics; D009363:Neoplasm Proteins / Q000096:biosynthesis; D012334:RNA, Neoplasm / Q000096:biosynthesis; D014405:Tuftsin / Q000494:pharmacology*
D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; D014405:Tuftsin