Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan.
Repeated administration of the hepatic lectin blocking agents D-galactose or arabinogalactan completely prevented the settling of metastatic cells of sarcoma L-1 tumor in the liver of Balb/c mice and greatly reduced the colonization process of highly metastatic ESb lymphoma cells of the liver of DBA/2 mice. Therefore, when hepatic lectins were blocked with competitive glycoconjugates, tumor cell colonization of the liver could be prevented in two different model systems.
Beuth
J
J
Institute of Hygiene, University of Cologne, F.R. Germany.
Ko
H L
HL
Schirrmacher
V
V
Uhlenbruck
G
G
Pulverer
G
G
D000818:Animals; D005685:Galactans / Q000494:pharmacology*; D005690:Galactose / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D037102:Lectins / Q000037:antagonists & inhibitors*; D007940:Leukemia L5178 / Q000473:pathology*; D007942:Leukemia, Experimental / Q000473:pathology*; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008114:Liver Neoplasms, Experimental / Q000517:prevention & control / Q000556:secondary*; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D012513:Sarcoma, Experimental / Q000473:pathology / Q000556:secondary*
D005685:Galactans; D037102:Lectins; C005653:arabinogalactan; D005690:Galactose