title: Evaluation of single-dose cefazolin prophylaxis for toxic shock syndrome.
abstract: Otolaryngologists have increased their use of parenteral prophylactic antibiotics to prevent toxic shock syndrome following nasal surgery. This rare but potentially serious postoperative complication presumably requires nasal carriage of a toxigenic strain of Staphylococcus aureus by a susceptible patient. We investigated the effect of a single preoperative dose of intravenous cefazolin on nasal carriage of S aureus. Thirty patients were studied; 15 were S aureus carriers initially and 12 (80%) remained culture positive after prophylaxis and at the time surgery was completed. We conclude that this particular regimen is unlikely to have a major effect on the incidence of toxic shock syndrome following nasal surgery.
authors.affiliation: Division of Infectious Disease, LDS Hospital, Salt Lake City, UT 84143.
authors.forename: J A
authors.initials: JA
authors.lastname: Jacobson
authors.forename: M H
authors.initials: MH
authors.lastname: Stevens
authors.forename: E M
authors.initials: EM
authors.lastname: Kasworm
mesh_terms: D002437:Cefazolin / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005069:Evaluation Studies as Topic; D006801:Humans; D007275:Injections, Intravenous; D009666:Nose / Q000382:microbiology / Q000601:surgery; D011292:Premedication; D011446:Prospective Studies; D012772:Shock, Septic / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000302:isolation & purification
chemical_list: D002437:Cefazolin