title: Effect of elective surgical procedures on tissue protein synthesis.
abstract: The purpose of the study was to examine whether an early decrease in protein synthesis rates occurred in any tissues after abdominal surgery in postprandial rats. Leucine-specific radioactivity in mixed protein and on tRNA was determined after continuous infusion of L-[3H]leucine. Synthesis rates of mixed protein were significantly decreased in the gastrocnemius muscle, but not in the jejunum, liver, or heart, of rats 1-2 hr after splenectomy and ovariectomy or after combining the groups that had various types of abdominal surgery. These results suggest that a very early decrease in the protein synthesis rate of the gastrocnemius muscle occurs after laparotomy.
authors.affiliation: Department of Surgery, University of Texas Medical School, Houston 77225.
authors.forename: V
authors.initials: V
authors.lastname: Bakic
authors.forename: B V
authors.initials: BV
authors.lastname: MacFadyen
authors.forename: F W
authors.initials: FW
authors.lastname: Booth
mesh_terms: D000005:Abdomen / Q000601:surgery; D000818:Animals; D005260:Female; D007583:Jejunum / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010052:Ovariectomy; D014176:Protein Biosynthesis; D051381:Rats; D013156:Splenectomy; D013514:Surgical Procedures, Operative