Effects of ambient ozone on respiratory function in active, normal children.
Respiratory functions were measured on a daily basis by spirometry over a period of 4 wk at a summer camp at Fairview Lake in northwestern New Jersey. Fifty-three boys and 38 girls 8 to 15 yr of age participated in the study on at least 7 days; 37 children were in residence for 4 wk, 34 for the first 2 wk only; and 20 for the last 2 wk. There were 72 whites, 15 blacks, 3 Asians, and 1 Hispanic in the study group. Multiple regression analyses indicated that the O3 concentration in the previous hour, the cumulative daily O3 exposure during the hours between 9 A.M. and the function measurement, ambient temperature, and humidity were the most explanatory environmental variables for daily variations in function, with the 1 - h O3 concentration having the strongest influence. Linear regressions were performed for each child between O3 concentration and function, and all average slopes were significantly negative (p less than 0.05) for FVC, FEV1, PEFR, and FEF25-75 for all children, and for boys and girls separately. Comparable results were obtained in data subsets (i.e., children studied during the first or second 2 wk only, and for data sets truncated at O3 less than 80 and O3 less than 60 ppb). The average regression slopes (+/- SE) for FVC and FEV1, respectively, were -1.03 +/- 0.24 and -1.42 +/- 0.17 ml/ppb, whereas for PEFR and FEF25-75 they were -6.78 +/- 0.73 and -2.48 +/- 0.26 ml/s/ppb.(ABSTRACT TRUNCATED AT 250 WORDS)
Spektor
D M
DM
New York University Medical Center, Tuxedo.
Lippmann
M
M
Lioy
P J
PJ
Thurston
G D
GD
Citak
K
K
James
D J
DJ
Bock
N
N
Speizer
F E
FE
Hayes
C
C
D000293:Adolescent; D000393:Air Pollutants / Q000009:adverse effects*; D002165:Camping; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008450:Maximal Midexpiratory Flow Rate; D009515:New Jersey; D010126:Ozone / Q000009:adverse effects*; D005082:Physical Exertion; D012044:Regression Analysis; D012119:Respiration / Q000187:drug effects*; D013147:Spirometry; D013997:Time Factors; D014797:Vital Capacity
D000393:Air Pollutants; D010126:Ozone