title: Myocardial infarct extension: occurrence, outcome, and risk factors in the Multicenter Investigation of Limitation of Infarct Size.
abstract: The occurrence, outcome, and predictors of myocardial infarct extension were determined in 848 patients with acute myocardial infarction. An increase in the level of plasma MB creatine kinase activity was used to detect extension, which occurred in 71 of 848 patients (8.4%). For these patients, hospital mortality was more than four times higher than for those without extension (30% versus 7%, P less than 0.01). However, for patients surviving the initial hospitalization, there was no significant difference in mortality during the following year (12% compared with 9%). Multivariable analyses indicated that extension was more likely to occur in patients with recurrent ischemic pain during the second hospital day, a history of previous myocardial infarction, and ST segment depression on the admission electrocardiogram. The occurrence of extension in patients with two of these risk factors was more than twice that of patients without any of the risk factors (15.1% compared with 5.8%). Patients with these risk factors should be considered for early coronary angiography and possible intervention to prevent infarct extension and its sequellae.
authors.affiliation: Department of Medicine, Harvard Medical School, Boston, Massachusetts.
authors.forename: J E
authors.initials: JE
authors.lastname: Muller
authors.forename: R E
authors.initials: RE
authors.lastname: Rude
authors.forename: E
authors.initials: E
authors.lastname: Braunwald
authors.forename: T D
authors.initials: TD
authors.lastname: Hartwell
authors.forename: R
authors.initials: R
authors.lastname: Roberts
authors.forename: B E
authors.initials: BE
authors.lastname: Sobel
authors.forename: C
authors.initials: C
authors.lastname: Ritter
authors.forename: C B
authors.initials: CB
authors.lastname: Parker
authors.forename: A S
authors.initials: AS
authors.lastname: Jaffe
authors.forename: P H
authors.initials: PH
authors.lastname: Stone
mesh_terms: D000704:Analysis of Variance; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood; D006801:Humans; D007527:Isoenzymes; D009203:Myocardial Infarction / Q000201:enzymology / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D012307:Risk Factors; D012770:Shock, Cardiogenic / Q000209:etiology; D013318:Stroke Volume; D013997:Time Factors
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase