Ocular and cardiovascular response to topical carteolol 2% and timolol 0.5% in healthy volunteers.
Ocular and cardiovascular effects of carteolol 2%, timolol 0.5%, and dummy eyedrops have been measured in a single dose double-blind crossover study in six healthy volunteers. Both drugs lowered intraocular pressure and reduced exercise-induced tachycardia. Neither produced a significant change in resting heart rate or blood pressure. The two agents appear comparable as regards ocular hypotensive and cardiovascular effects.
Brazier
D J
DJ
Department of Clinical Pharmacology, St Thomas's Hospital Medical School (UMDS), London.
Smith
S E
SE
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002354:Carteolol / Q000008:administration & dosage / Q000494:pharmacology*; D003864:Depression, Chemical; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D005082:Physical Exertion; D011412:Propanolamines / Q000494:pharmacology*; D013999:Timolol / Q000008:administration & dosage / Q000494:pharmacology*
D009883:Ophthalmic Solutions; D011412:Propanolamines; D013999:Timolol; D002354:Carteolol