title: Two different theta (theta) globin gene deletions observed among black newborn babies.
abstract: Two different theta 1 globin gene deletions have been detected in the Black population of the southeastern U.S.A. Restriction mapping of the alpha globin gene cluster indicated that one deletion removes approximately 1.8 kb of DNA including most of the theta 1 globin gene, while the second removes approximately 6 kb of DNA including the entire theta 1 globin gene. These defects do not cause haematological alterations in the newborn or in the adult (established for the smaller deletion only), nor were changes observed in polypeptide chain patterns at birth.
authors.affiliation: Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912-3331.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Fei
authors.forename: S
authors.initials: S
authors.lastname: Fujita
authors.forename: T H
authors.initials: TH
authors.lastname: Huisman
mesh_terms: D000328:Adult; D044383:Black People; D002675:Child, Preschool; D002872:Chromosome Deletion; D005260:Female; D005845:Georgia; D005914:Globins / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D001741:Black or African American
chemical_list: D005914:Globins