Role of the implantation site on metastatic ability of the murine MBT-2 transitional cell carcinoma.
The influence of implantation site on the metastatic behavior of a murine transitional cell carcinoma line (MBT-2) was examined. MBT-2 cells were injected into one of four anatomic sites; subcutaneously, intramuscularly, intravenously or into the footpad, to evaluate the influence of implantation site on the formation and number of metastases. The MBT-2 cell line produced a low incidence of lung metastases after intravenous injection with a mean of 1.1 lung tumors per mouse. Injection of MBT-2 cells into the footpad or subcutaneously did not produce metastases from the primary tumor. Intramuscular implantation, however, resulted in a sixty percent incidence of metastasis with a mean of 8.2 lung nodules per mouse. This study demonstrated a definite implantation site influence on the metastatic ability of the MBT-2 line.
Klaunig
J E
JE
Department of Pathology, Medical College of Ohio, Toledo.
Barut
B A
BA
D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced / Q000473:pathology*; D005200:FANFT; D051379:Mice; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured / Q000473:pathology
D005200:FANFT