Effect of synthetic human cholecystokinin-33 on exocrine pancreas.
Synthetic human cholecystokinin-33 was first evaluated with respect to the biological activity on the pancreatic protein secretion. Human cholecystokinin-33 increased pancreatic protein secretion in a dose-related manner. The relative molar potency of this substance compared to that of synthetic cholecystokinin-8 (taken as 1.0) was 0.92. This study supports the concept that longer molecular forms of cholecystokinin are quantitatively important mediators of biological action of cholecystokinin on the pancreas.
Doi
R
R
Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Inoue
K
K
Kogire
M
M
Sumi
S
S
Yun
M
M
Futaki
S
S
Fujii
N
N
Yajima
H
H
Tobe
T
T
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D004285:Dogs; D006801:Humans; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D012844:Sincalide / Q000494:pharmacology
D011506:Proteins; D002766:Cholecystokinin; D012844:Sincalide