Induction of neoplasms in the Egyptian toad Bufo regularis by gibberellin A3.
Force feeding the Egyptian toads (Bufo regularis) with gibberellin A3 (10 ppm) twice a week for 5 months induced neoplasms in 8 out of 50 (16%) experimental animals. Primary tumours developed in the liver (hepatocellular carcinomas). Two secondary tumours in the kidneys and another 2 in the ovaries of toads developed due to metastases from the hepatocellular carcinomas. The results show that gibberellic acid (gibberellin A3) has a carcinogenic effect in the Egyptian toads.
el-Mofty
M M
MM
Zoology Department, Faculty of Science, Alexandria University, Egypt.
Sakr
S A
SA
D000818:Animals; D002025:Bufonidae / Q000502:physiology*; D005260:Female; D005875:Gibberellins / Q000633:toxicity*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology
D005875:Gibberellins