title: [Clinical evaluation of combination therapy with Fortimicin and Cefotax in the treatment of complicated urinary tract infections].
abstract: Clinical efficacy of combination therapy using Fortimicin (ASTM) and Cefotax (CTX) was studied in 63 patients with complicated urinary tract infections. The patients received 200 mg of ASTM i.m. and 1 g of CTX i.v. twice a day. The overall clinical efficacy of the treatment was evaluated by criteria proposed by the Japanese UTI Committee. The overall clinical efficacy rate was 68.3%. The rate was 67.3% in the patients with single bacterial infection and 72.7% in those with mixed infections. Subjective side effects were observed in one of the patients. Drug related aggravation in laboratory tests was observed in 8 items in 8 patients, but these were mild changes. We concluded that combination therapy with ASTM and CTX was useful for the treatment of complicated urinary tract infections.
authors.affiliation: Department of Urology, School of Medicine, Hokkaido University.
authors.forename: S
authors.initials: S
authors.lastname: Sakashita
authors.forename: Y
authors.initials: Y
authors.lastname: Asano
authors.forename: M
authors.initials: M
authors.lastname: Togashi
authors.forename: A
authors.initials: A
authors.lastname: Maru
authors.forename: T
authors.initials: T
authors.lastname: Koyanagi
authors.forename: T
authors.initials: T
authors.lastname: Kasai
authors.forename: T
authors.initials: T
authors.lastname: Namiji
authors.forename: K
authors.initials: K
authors.lastname: Mitsuhashi
authors.forename: I
authors.initials: I
authors.lastname: Amino
authors.forename: T
authors.initials: T
authors.lastname: Kaneta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001419:Bacteria / Q000302:isolation & purification; D002439:Cefotaxime / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C023384:fortimicin A; D002439:Cefotaxime