title: Tolerance of fat emulsions in very-low-birthweight neonates. Monitoring of plasma lipid concentrations.
abstract: Tolerance to parenterally administered fat emulsions was studied in 45 normally grown neonates ranging from 820 to 1550 gm in birthweight, from 27 to 34 weeks in gestational age, and from 2 to 10 days postnatal age. Concentrations of total lipids, free glycerol, true triglycerides, free fatty acids, and cholesterol in plasma were studied over an 8-day period. The aim was to determine whether the concentrations of any one lipid fraction could be used to predict those of other fractions. With 650 pairs of data being correlated, the best correlation coefficients were obtained between total lipids and triglycerides (r = 0.67), total lipids and cholesterol (r = 0.63), free glycerol and free fatty acids (r = 0.55), total lipids and free fatty acids (r = 0.54), and triglycerides and free fatty acids (r = 0.50). Although all correlation coefficients were highly significant statistically (P less than 0.001), the very large standard errors precluded using any of these relationships to make clinical predictions. Problems and limitations of currently available techniques are discussed in order to provide a lead for further research.
authors.affiliation: Department of Pediatrics, University of Texas Health Science Center, San Antonio.
authors.forename: Y W
authors.initials: YW
authors.lastname: Brans
authors.forename: D S
authors.initials: DS
authors.lastname: Andrew
authors.forename: D W
authors.initials: DW
authors.lastname: Carrillo
authors.forename: E B
authors.initials: EB
authors.lastname: Dutton
authors.forename: E M
authors.initials: EM
authors.lastname: Menchaca
authors.forename: B A
authors.initials: BA
authors.lastname: Puleo-Scheppke
mesh_terms: D001724:Birth Weight; D002784:Cholesterol / Q000097:blood; D004361:Drug Tolerance; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005865:Gestational Age; D005990:Glycerol / Q000097:blood; D006801:Humans; D007230:Infant, Low Birth Weight / Q000097:blood*; D007231:Infant, Newborn; D008055:Lipids / Q000097:blood*; D008297:Male; D008991:Monitoring, Physiologic; D014280:Triglycerides / Q000097:blood
chemical_list: D005217:Fat Emulsions, Intravenous; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D005990:Glycerol