title: Colonic neoplasms in asymptomatic first-degree relatives of colon cancer patients.
abstract: First-degree relatives of colon cancer patients are at elevated risk for developing colorectal neoplasms. In order to assess the potential usefulness of screening by colonoscopy in this high-risk population, we reviewed the records of 48 colonoscopies performed on asymptomatic patients who were self- or physician-referred for colonoscopy because of a history of one or more first-degree relatives with colon cancer. Twelve (25%) had at least one adenomatous polyp, but no significant atypia was detected. No cancers were detected. One third of the lesions were beyond the reach of a flexible sigmoidoscope. This apparent increase in the prevalence of adenomas was most striking (46%) among men over the age of 50. These preliminary results demonstrate that colonoscopy is effective in detecting and removing adenomatous polyps in a substantial fraction of asymptomatic patients whose sole risk-factor is being a first-degree relative of a patient with colon cancer. Further studies in larger populations are warranted to determine the use of colonoscopy in screening these high-risk individuals.
authors.affiliation: Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York.
authors.forename: J G
authors.initials: JG
authors.lastname: Guillem
authors.forename: A I
authors.initials: AI
authors.lastname: Neugut
authors.forename: K A
authors.initials: KA
authors.lastname: Forde
authors.forename: J D
authors.initials: JD
authors.lastname: Waye
authors.forename: M R
authors.initials: MR
authors.lastname: Treat
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000235:genetics*; D003111:Colonic Polyps / Q000235:genetics; D003113:Colonoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors