Temporal profile of thromboxane-prostacyclin imbalance in experimental spinal cord injury.
Thromboxane-prostacyclin imbalance may be an important determinant of platelet-vessel wall interactions that are vital in circulatory homeostasis. In experimental spinal cord injury, the vascular damage contributes substantially to the process of progressive secondary injury culminating in post-traumatic myelopathy. In this study, we found a time-dependent alteration of thromboxane-prostacyclin balance in the injured spinal cord with thromboxane dominance during the first 2 h: a time when maximal vascular injury is reflected by extravasation of 125I-labelled serum albumin. The thromboxane-prostacyclin imbalance reverted to favor prostacyclin by 18 h post-injury. This time-dependent alteration of thromboxane-prostacyclin balance should be considered in the planning of therapeutic attempts to prevent secondary injury by pharmacological modulation of platelet-vessel wall interaction.
Hsu
C Y
CY
Department of Neurology, Medical University of South Carolina, Charleston 29425.
Halushka
P V
PV
Spicer
K M
KM
Hogan
E L
EL
Martin
H F
HF
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism*; D000818:Animals; D001808:Blood Vessels / Q000293:injuries*; D006706:Homeostasis; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism*; D013119:Spinal Cord Injuries / Q000378:metabolism / Q000503:physiopathology*; D013929:Thromboxane B2 / Q000378:metabolism*; D013997:Time Factors
D012709:Serum Albumin; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha