[Lithogenicity and bile acid pattern in choleretic administration (3-n-butoxy-1-phenoxy-propanol: febuprol) in patients with functional right upper quadrant pain].
10 patients with right upper quadrant pain were treated with a choleretic agent (Febuprol; 3 X 200 mg t. i. d.) and placebo in a cross-over double dummy technique for 16 weeks. Lithogenic index, bile acid profile and serum lipids were determined every 4 weeks. During Febuprol application the clinical symptoms were relieved (0.87 +/- 1.3 vs. 1.39 +/- 0.21 (placebo); p less than 0.05, semiquantitative score). Biliary lithogenicity (1.45 +/- 0.6 vs. 1.09 +/- 0.12; n. s.), bile acid profile and serum lipids showed no statistically significant change, although serum cholesterol levels seemed to fall during Febuprol application.
Swobodnik
W
W
Abteilung Innere Medizin II, Universitätsklinik Ulm.
Wechsler
J G
JG
Klüppelberg
U
U
Janowitz
P
P
Hutt
V
V
Ditschuneit
H
H
D000433:1-Propanol / Q000627:therapeutic use; D000328:Adult; D001647:Bile Acids and Salts / Q000097:blood*; D002756:Cholagogues and Choleretics; D002769:Cholelithiasis / Q000097:blood / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010647:Phenyl Ethers; D020005:Propanols
D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D008055:Lipids; D010647:Phenyl Ethers; D020005:Propanols; D000433:1-Propanol; C006281:febuprol
Lithogeniät und Gallensäurenmuster unter Choleretikagabe (3-n-Butoxy-1-phenoxy-propanol: Febuprol) bei Patienten mit funktionellen rechtsseitigen Oberbauchbeschwerden.