title: Lower prevalence of chromosome aberrations and SCEs in self-poisoned pregnant women.
abstract: A cytogenetic investigation was conducted in 18 self-poisoned pregnant and 16 self-poisoned non-pregnant women and in 31 pregnant and non-pregnant controls. Blood samples for analysis of chromosomal aberrations and SCEs were collected from women who were at different early stages of pregnancy. The difference between self-poisoned women and controls was very highly significant in the case of chromatid-type and unstable chromosome-type aberrations and highly significant in the case of SCEs. Further, the frequency of chromatid aberrations in pregnant women relative to non-pregnant ones was significantly lower suggesting a possible protective effect of pregnancy.
authors.affiliation: Department of Human Genetics and Teratology, National Institute of Hygiene, Budapest, Hungary.
authors.forename: T T
authors.initials: TT
authors.lastname: Huong
authors.forename: I
authors.initials: I
authors.lastname: Szentesi
authors.forename: A
authors.initials: A
authors.lastname: Czeizel
mesh_terms: D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations; D003975:Diazepam / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D011041:Poisoning / Q000097:blood / Q000235:genetics*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000235:genetics*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013405:Suicide / Q000097:blood / Q000235:genetics
chemical_list: D003975:Diazepam