title: Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements.
abstract: Oncogenes have been implicated in tumorigenesis based on their localization to chromosomal sites associated with tumor-specific structural rearrangements. We have mapped the human ros1 (formerly mcf3) and mas1 oncogenes to the distal half of chromosome 6q, within a region frequently rearranged in malignant cells. Chromosomal mapping of these two new human transforming genes may help elucidate the involvement of the long arm of chromosome 6 in diverse tumor types.
authors.affiliation: University of Miami School of Medicine, Department of Pediatrics, Florida 33101.
authors.forename: M
authors.initials: M
authors.lastname: Rabin
authors.forename: D
authors.initials: D
authors.lastname: Birnbaum
authors.forename: D
authors.initials: D
authors.lastname: Young
authors.forename: C
authors.initials: C
authors.lastname: Birchmeier
authors.forename: M
authors.initials: M
authors.lastname: Wigler
authors.forename: F H
authors.initials: FH
authors.lastname: Ruddle
mesh_terms: D002460:Cell Line; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D011905:Genes, ras; D006801:Humans; D007938:Leukemia / Q000235:genetics; D009369:Neoplasms / Q000235:genetics; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D000090063:Proto-Oncogene Mas