Methylglyoxal bis(cyclohexylamidinohydrazone), a novel inhibitor of polyamine biosynthesis that simultaneously inhibits S-adenosylmethionine decarboxylase and spermidine synthase.
Hibasami
H
H
Department of Biochemistry, Mie University School of Medicine, Japan.
Tsukada
T
T
Maekawa
S
S
Nakashima
K
K
D012437:Adenosylmethionine Decarboxylase / Q000037:antagonists & inhibitors*; D001667:Binding, Competitive; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D007700:Kinetics; D008935:Mitoguazone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D011073:Polyamines / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D011436:Spermidine Synthase / Q000037:antagonists & inhibitors*; D014166:Transferases / Q000037:antagonists & inhibitors*
D011073:Polyamines; C054653:methylglyoxal bis(cyclohexylamidinohydrazone); D014166:Transferases; D011436:Spermidine Synthase; D002262:Carboxy-Lyases; D012437:Adenosylmethionine Decarboxylase; D008935:Mitoguazone