title: Formation and propagation of brain oedema fluid around human brain metastases. A CT Study.
abstract: Computerized tomography (CT) was used to examine the time-course of the propagation of extravasated contrast medium from small brain metastases into the peritumoural oedematous white matter, following infusion of 200 ml of meglumine amidtrizoate for 3 hours. Four patients with a metastatic brain tumour were examined. CT scans at identical levels were taken 1.5, 3, 6, 9, and 12 hours after start of contrast infusion. Following 4-7 days of dexamethasone treatment (8-12 mg/day i.v.) the examination was repeated. A contrast-enhanced area was observed surrounding the clearly delineated tumours, expanding gradually in a circular fashion into the peritumoural white matter oedema. The expanding circular enhancement was measured planimetrically on the various scans. From these values, the increase in radius/hr respectively in volume/hr was calculated, assuming a spherical geometry. This enabled a determination of the rate of oedema fluid formation and of the speed of oedema fluid propagation. The formation rate of oedema fluid amounted to 0.5-3.2 ml/hour and the speed of oedema fluid spreading to 1.9 mm/hour. Following treatment with dexamethasone the formation rate of oedema fluid is reduced by 30-50%. The important clinical implications of these new findings are discussed.
authors.affiliation: Department of Neurosurgery, Musasino Red-Cross Hospital, Tokyo.
authors.forename: U
authors.initials: U
authors.lastname: Ito
authors.forename: H J
authors.initials: HJ
authors.lastname: Reulen
authors.forename: H
authors.initials: H
authors.lastname: Tomita
authors.forename: J
authors.initials: J
authors.lastname: Ikeda
authors.forename: J
authors.initials: J
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Maehara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001929:Brain Edema / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D001932:Brain Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000556:secondary; D003287:Contrast Media; D003907:Dexamethasone / Q000627:therapeutic use; D003974:Diatrizoate Meglumine; D006801:Humans; D008875:Middle Aged; D008962:Models, Theoretical; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D003974:Diatrizoate Meglumine; D003907:Dexamethasone