[Remarkable effect of vindesine sulfate (VDS) in the treatment of metachronous lung metastasis of esophageal cancer--a case report].
A case of metachronous lung metastasis treated by intravenous administration of VDS after esophageal cancer surgery is reported. A 63-year-old man who had undergone intrathoracic esophagectomy for cancer of the esophagus was shown to have a coin lesion in the middle lobe of the right lung on X-ray examination about one year after surgery. The schedule for intravenous administration of VDS was 5 mg/body every week. The metastatic lesion disappeared after a series VDS administrations totalling 35 mg. Major side effects such as leukopenia and fever were occasionally observed during the course of drug administration. The patient required three occasions of hospitalization for these adverse effects. It is thus emphasized that an effect of VDS may be expected for hematogenous dissemination of esophageal cancer.
Hasegawa
M
M
1st Dept. of Surgery, Niigata University.
Suzuki
S
S
Miyashita
K
K
Suzuki
T
T
Tanaka
O
O
Sasaki
K
K
Muto
T
T
D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000556:secondary; D004334:Drug Administration Schedule; D004938:Esophageal Neoplasms / Q000601:surgery; D004947:Esophagus / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012074:Remission Induction; D014751:Vindesine / Q000008:administration & dosage* / Q000627:therapeutic use
D014751:Vindesine