Neuron-specific enolase in comatose children.
Sequential examination of neuron-specific enolase in cerebrospinal fluid and serum was performed in 20 comatose children with acute encephalitis, acute encephalopathy, or Reye's syndrome. Neuron-specific enolase activities corresponded to the degree of brain damage. As neuron-specific enolase levels increased to greater than 80 ng/mL, patients had more severe impairment or died. Neuron-specific enolase may be a useful marker for evaluating the degree of neuronal damage and prognosis.
Nara
T
T
Division of Neurology, Children's Medical Center, Saitama, Japan.
Nozaki
H
H
Nakae
Y
Y
Arai
T
T
Ohashi
T
T
D000208:Acute Disease; D001927:Brain Diseases / Q000201:enzymology; D002648:Child; D003128:Coma / Q000201:enzymology*; D004660:Encephalitis / Q000201:enzymology; D005260:Female; D006801:Humans; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D011379:Prognosis; D012202:Reye Syndrome / Q000201:enzymology
D010751:Phosphopyruvate Hydratase