Chromosomal damage induced by maleic hydrazide in mammalian cells in vitro and in vivo.
The induction of sister-chromatid exchanges (SCE) and chromosomal aberrations (Ch.Ab.) by the herbicide maleic hydrazide (MH) has been investigated in Chinese hamster ovary (CHO) cells grown in vitro and in bone marrow cells of mice treated in vivo. MH induces SCE and Ch.Ab. in CHO cells without metabolic activation; however, no induction of SCE was found in the in vivo experiments.
Meschini
R
R
C.N.R., Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, Roma, Italy.
Quaranta
M T
MT
Fiore
M
M
Polcaro
C
C
Possagno
E
E
Palitti
F
F
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002453:Cell Cycle; D002460:Cell Line; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D006224:Cricetinae; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008300:Maleic Hydrazide / Q000633:toxicity*; D051379:Mice; D011724:Pyridazines / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects
D011724:Pyridazines; D008300:Maleic Hydrazide