Cardiopulmonary function in long-term survivors of childhood Hodgkin's lymphoma: a pilot study.
Twelve patients who had received mantle radiotherapy for Hodgkin's lymphoma during childhood underwent cardiopulmonary testing 7 years or more after the initial diagnosis and treatment. All but one patient had been asymptomatic. Results of echocardiography, pulmonary function tests, or exercise studies were abnormal in 9 of the 12 patients. Long-term follow-up of cardiopulmonary function will be important to determine the ultimate significance of these abnormalities. These potential complications must be considered in planning prospective therapeutic studies in children with Hodgkin's disease.
Kadota
R P
RP
Section Pediatric Hematology/Oncology, Mayo Clinic, Rochester, MN 55905.
Burgert
E O
EO
Driscoll
D J
DJ
Evans
R G
RG
Gilchrist
G S
GS
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006334:Heart Function Tests; D006689:Hodgkin Disease / Q000188:drug therapy / Q000503:physiopathology* / Q000532:radiotherapy; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D013902:Radiography, Thoracic; D012129:Respiratory Function Tests