Partial degeneration of autonomic nerves of the heart of methotrexate-treated guinea pigs.
In the present investigation partial degeneration of adrenergic and cholinergic nerves of the heart of guinea pigs following methotrexate treatment has been reported. No appreciable change was observed in the autonomic nerve fibres after 3 days of treatment. However, after prolonged treatment some nerve fibres showed signs of degeneration and a few adrenergic and cholinergic nerve fibres had disappeared.
Qayyum
M A
MA
Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Fatani
J A
JA
el-Badawi
M G
MG
D000818:Animals; D001341:Autonomic Nervous System; D002802:Cholinesterases / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000294:innervation*; D006651:Histocytochemistry; D008297:Male; D008727:Methotrexate / Q000494:pharmacology*; D008856:Microscopy, Fluorescence; D009410:Nerve Degeneration / Q000187:drug effects*
D002802:Cholinesterases; D008727:Methotrexate