A mitochondrial frameshift-suppressor (+1) [corrected] of the yeast S. cerevisiae maps in the mitochondrial 15S rRNA locus.
The first case of a +1 "extrageneic" frameshift suppressor (MF1), mapping in the yeast mitochondrial 15S rRNA gene is reported. The suppressor was identified by genetic analyses in a leaky mitochondrial oxil frameshift mutant and the respective wild-type strain 777-3A of the yeast S. cerevisiae. This is in accordance with the finding that all mitochondrial frameshift mutants isolated from this strain tend to be leaky to a variable degree. MF1 does not suppress known nonsense mutations created by a direct basepair exchange in strain 777-3A. These mutants exhibit a non-leaky phenotype (Weiss-Brummer et al. 1984).
Weiss-Brummer
B
B
Institut für Genetik und Mikrobiologie, Lehrstuhl für Genetik, Universität München, Federal Republic of Germany.
Sakai
H
H
Kaudewitz
F
F
D002872:Chromosome Deletion; D004272:DNA, Mitochondrial / Q000235:genetics; D005800:Genes, Fungal; D005838:Genotype; D010641:Phenotype; D012335:RNA, Ribosomal / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D013045:Species Specificity; D013489:Suppression, Genetic
D004272:DNA, Mitochondrial; D012335:RNA, Ribosomal