title: Scar formation following impulse noise-induced mechanical damage to the organ of Corti.
abstract: The terminal stages of the healing process of the organ of Corti in the chinchilla following exposure to blast-waves at 160 dB peak SPL, were studied by scanning electron microscopy (SEM) and by surface preparation technique. Extensive lesions of the sensory epithelia consisting in the absence of the OHC's, Deiter cells and Hensen cells, were replaced by scar tissue formed by single, flat, irregularly polygonal cells, arising from the Claudius cell area sealing off the endolymphatic spaces. When the pillar cells have been destroyed the scar epithelium from the Claudius cells has reached the IHC's, which show a remarkable resistance to acoustic trauma. Their presence in a large healed area may be the only remnants of a previous sensory region. When even the IHC's are absent, the entire organ of Corti can be replaced both by Claudius cells and by inner sulcus cells covering the denuded basilar membrane without any clear morphological difference between the two cellular sources.
authors.affiliation: Department of Bioacoustics, University of Bari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Roberto
authors.forename: F
authors.initials: F
authors.lastname: Zito
mesh_terms: D000818:Animals; D001753:Blast Injuries / Q000150:complications* / Q000473:pathology; D002682:Chinchilla; D002921:Cicatrix / Q000209:etiology* / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D009622:Noise / Q000009:adverse effects*; D009925:Organ of Corti / Q000293:injuries* / Q000648:ultrastructure