title: Effect of plutonium-239 on the mitotic activity of mouse bone marrow cells.
abstract: Mitotic index of the bone marrow cells was studied in femoral bone marrow of mice given 313 kBq 239Pu kg-1. The attention was turned to the femoral midshaft and the mitosis concentration, intensified by Colcemid stathmokinetic effect, was evaluated in a sampling field from endosteal surface to the central venous canal, throughout 68 weeks. It has been found that the plutonium effect in the sampling band is rather uniform except the points in subendosteal zone early after plutonium injection, where the mitotic index was reduced in such a way that the mitotic gradient, observed in controls, was affected. The mitotic activity in femoral diaphysis of plutonium injected mice was mobilized approximately till the 30th week of contamination. Later it deteriorated progressively. The results are discussed and should not be regarded as representative for the entire bone marrow hemopoiesis.
authors.affiliation: Institute of Hygiene and Epidemiology, Center of Radiation Hygiene, Prague, Czechoslovakia.
authors.forename: V
authors.initials: V
authors.lastname: Svoboda
authors.forename: D
authors.initials: D
authors.lastname: Bubeníková
authors.forename: A
authors.initials: A
authors.lastname: Sedlák
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D001854:Bone Marrow Cells; D005260:Female; D007275:Injections, Intravenous; D051379:Mice; D008938:Mitosis / Q000528:radiation effects*; D011005:Plutonium / Q000008:administration & dosage
chemical_list: D011005:Plutonium