Nonesterified fatty acids: role in the molecular events linking endocrinology and oncology via nutrition.
It is more and more clear from recent studies that both steroid and peptide (hormone and growth factor)-mediated pathways of mitogenesis are closely linked. These two pathways are intertwined into a highly regulated network. The two main points of connection are at the level of lipase and protease biosynthesis and regulating systems. Both enzymes are steroid-regulated. Furthermore, free fatty acids can be considered as positive or negative common modulators and/or messengers of the steroids and the peptide factors regulating the mitogenic processes.
Nunez
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EA
U.224, INSERM, Faculté de Médecine Xavier-Bichat, Laboratoire de Biochimie, Paris, France.
D000818:Animals; D002455:Cell Division; D004041:Dietary Fats / Q000009:adverse effects*; D005230:Fatty Acids, Nonesterified / Q000009:adverse effects*; D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D013256:Steroids / Q000502:physiology*
D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D013256:Steroids