Influence of verapamil and its combination with glucose-insulin-potassium-infusion on acute myocardial ischemia in dogs.
The influence of verapamil (V) and of V combined with glucose-insulin-potassium (VG) on ischemic injured myocardium was investigated in dogs after ligation of the left anterior descending coronary artery. Three hours after coronary artery ligation with VG application during the last two hours the left ventricular end diastolic pressure (LVEDP) and the pressure rate product were decreased in contrast to the behaviour after V infusion. Contents of ATP and creatine phosphate were preserved in equal extent by V and VG, but the lowest content in inorganic phosphate was found in ischemic and nonischemic left ventricular tissue after VG application. Thus, VG seems to enable the tissue to save more effective energy rich phosphates and to contribute to the economization of cardiac work by reduction of preload.
Goos
H
H
Department of Cardiovascular Surgery, Karl-Marx-University, Leipzig.
Pissarek
M
M
Nöhring
J
J
Graff
J
J
Buller
G
G
Lindenau
K F
KF
Beyerdörfer
I
I
Krause
E G
EG
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002314:Cardioplegic Solutions / Q000008:administration & dosage; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004359:Drug Therapy, Combination; D005947:Glucose / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage; D009206:Myocardium / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D011188:Potassium / Q000008:administration & dosage; D014700:Verapamil / Q000008:administration & dosage*
D002314:Cardioplegic Solutions; D007328:Insulin; D010710:Phosphates; C030396:glucose-insulin-potassium cardioplegic solution; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D014700:Verapamil; D005947:Glucose; D011188:Potassium