Study of the bioavailability of different formulations of 8-methoxypsoralen in the dog.
The absolute bioavailability of 8-methoxypsoralen in gelatin capsules and as a solution was studied in dogs. A dose of 2 mg kg-1 was given. Both for the solution and the gelatin capsules, a large variation in bioavailability was found between the different dogs. For the gelatin capsules in 1 dog out of 4 an absolute bioavailability of more than 100 per cent was found; for the solution a bioavailability of more than 100 per cent was found in all 4 dogs. Resorption was more rapid and bioavailability higher for the solution than for the gelatin capsules. Relative bioavailability of an emulsion and of a solution of 8-methoxypsoralen was studied in 2 dogs. A faster resorption and a higher bioavailability were found for the solution.
Monbaliu
J G
JG
Heymans Institute of Pharmacology, University of Gent Medical School, Belgium.
Belpaire
F M
FM
Bogaert
M G
MG
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002214:Capsules; D004285:Dogs; D004655:Emulsions; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D008730:Methoxsalen / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011208:Powders; D012996:Solutions
D002214:Capsules; D004655:Emulsions; D011208:Powders; D012996:Solutions; D008730:Methoxsalen