title: Cellular requirements of IgE-antibody regulation.
abstract: Regulation of IgE antibody response is T-cell dependent. It has been suggested that IL-4 (BSF-1) induces the expression of Fc epsilon RII on B-lymphocytes. Soluble molecules of the FC epsilon RII with various molecular weights represent IgE-binding factors which according to the current opinion either enhance or suppress the IgE-antibody response. In mice IgE suppressive factors were obtained, which inhibited IgE-synthesis in vitro and in vivo. IgE suppressive factors were also obtained by incubating MLN-cells with monoclonal IgE. In humans IgE binding factors are present within serum of normal donors. In atopics IgE-BF is apparently complexed with IgE. Thus, it becomes clear that the expression of IgE-bearing lymphocytes as well as the secretion of IgE is cytokine mediated.
authors.affiliation: RUHR-Universitt Bochum, Institut für Hygiene and Mikrobiologie, Bochum, FRG.
authors.forename: W
authors.initials: W
authors.lastname: König
authors.forename: P
authors.initials: P
authors.lastname: Pfeil
authors.forename: U
authors.initials: U
authors.lastname: Hofmann
authors.forename: J
authors.initials: J
authors.lastname: Bujanowski-Weber
authors.forename: I
authors.initials: I
authors.lastname: Knöller
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000494:pharmacology*; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000494:pharmacology; D015847:Interleukin-4; D007378:Interleukins / Q000494:pharmacology; D008222:Lymphokines / Q000494:pharmacology; D051379:Mice
chemical_list: D002352:Carrier Proteins; D006133:Growth Substances; D007376:Interleukin-2; D007378:Interleukins; D008222:Lymphokines; D015847:Interleukin-4; D007073:Immunoglobulin E