Antimycotic action of methyl substituted N-(5-pyrimidinyl)benzenesulfonamide derivatives.
Some series of N-(5-pyrimidinyl)benzenesulfonamide variously methylated at the ring and/or sulfonamidic nitrogens and substituted at the benzene with NO2 or NH2 were synthesized and studied spectrometrically (N.M.R). When tested on several strains of Candida albicans and Candida tropicalis, some of the compounds exhibited very slight antimycotic activity.
Pecorari
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P
Dipartimento di Scienze Farmaceutiche, Università di Modena, Italy.
Vampa
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G
Albasini
A
A
Provvisionato
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A
D000935:Antifungal Agents / Q000138:chemical synthesis*; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D013449:Sulfonamides / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology
D000935:Antifungal Agents; D011743:Pyrimidines; D013449:Sulfonamides