title: Mathematical models of cumulative effect and optimization of fractionation regimes.
abstract: Different (most known) mathematical models are shortly described and basic assumptions the individual models are based on are discussed and critically examined. Advantages and shortages of individual models are mentioned. A semiphenomenological model is then used to demonstrate some possibilities how to make use of the mathematical models in attempts of optimizing the fractionation approaches in individual cases.
authors.affiliation: Oncological clinic of Faculty Hospital, Prague.
authors.forename: L
authors.initials: L
authors.lastname: Judas
authors.forename: M
authors.initials: M
authors.lastname: Lokajícek
authors.forename: K
authors.initials: K
authors.lastname: Prokes
mesh_terms: D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D011878:Radiotherapy; D011879:Radiotherapy Dosage