[In vitro activity of imipenem (N-formimidoylthienamycin), a new carbapenem antibiotic].
Imipenem is a beta-lactam carbapenem antibiotic, N-formimidoyl thienamycin-derivate. Imipenem is highly active against gram-negative aerobes and also highly active against gram-positive aerobes and virtually all anaerobes, with MICs very low and MBCs equal or only two-four dilution higher, it has a low degree of affinity for all types of beta-lactamases, shown a good post-antibiotic effect, it is a potent inhibitor to peptidoglycan with a greatest affinity for PBP2 and PBP1, in gram-negative bacteria, and for PBP3, PBP1 and PBP4, in gram-positive bacteria. The precocious bactericidal activity belongs to its low molecular weight, the characteristic of zwitterionic compound, to its hydrophobicity and to, in finally, its compact molecular structure.
Cavallo
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Istituto di Microbiologia, Torino.
Carlone
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NA
D015378:Imipenem; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology*
D013845:Thienamycins; D015378:Imipenem
Attività in vitro dell'imipenem (N-formimidoil tienamicina) un nuovo antibiotico carbapenemico.