title: Family size limitation: a method for demonstrating recessive inheritance.
abstract: Limitation of family size after the birth of a child with a serious disorder poses a problem in demonstrating autosomal recessive inheritance. In this paper methods are presented for distinguishing autosomal recessive inheritance given a 100% deterrent effect, and revealing a partial deterrent effect by analysis of sibship size and comparison with general population data. These methods are illustrated using information from phenylketonuria families.
authors.affiliation: Department of Genetics, University of Leicester.
authors.forename: J F
authors.initials: JF
authors.lastname: Brookfield
authors.forename: R J
authors.initials: RJ
authors.lastname: Pollitt
authors.forename: I D
authors.initials: ID
authors.lastname: Young
mesh_terms: D005193:Family Planning Services; D005808:Genes, Recessive; D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D010375:Pedigree; D010661:Phenylketonurias / Q000235:genetics*