Rhabdomyosarcoma in Roberts syndrome.
A 23-month-old child diagnosed as having Roberts syndrome, born to consanguineous parents, developed a sarcoma botryoides. Cytogenetic evaluation of peripheral blood lymphocytes and tumor cells showed premature centromere separation, which is characteristic of Roberts syndrome.
Wenger
S L
SL
Department of Medical Genetics, Children's Hospital of Pittsburgh, University of Pittsburgh, School of Medicine 15213-3417.
Blatt
J
J
Steele
M W
MW
Lloyd
D A
DA
Bellinger
M
M
Phebus
C K
CK
Horn
M
M
Jaffe
R
R
D000015:Abnormalities, Multiple; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007621:Karyotyping; D012208:Rhabdomyosarcoma / Q000150:complications / Q000235:genetics* / Q000473:pathology; D013577:Syndrome; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology