Quantifying risk and accuracy in cancer risk assessment: the process and its role in risk management problem-solving.
A better understanding of chemical-induced cancer has led to appreciation of similarities to problems addressed by risk management of radiation-induced toxicity. Techniques developed for cancer risk assessment of toxic substances can be generalized to toxic agents. A recent problem-solving approach for risk management of toxic substances developed for the U.S. Department of Health and Human Services, and the role of risk assessment and how uncertainty should be treated within the context of this approach, is discussed. Finally, two different methods, research into the assumptions underlying risk assessment and the modification of risk assessment/risk management documents, are used to illustrate how the technique can be applied.
Turturro
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A
National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079.
Hart
R W
RW
D006801:Humans; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D012307:Risk Factors