Frequency of tri- and multiradial configurations in fragile X chromosomes.
The appearance of tri- or multiradial configurations in fragile chromosomes is affected by the number of cell cycles in the folate antagonist system. In this study the lymphocytes were incubated for 96 h in a medium 199 without calf serum, and tri- or multiradial configurations were observed in 6 of 12 cases of fra(X) chromosome. The frequency ranged from 0.6% to 7.4% of fra(X) chromosomes.
Subrt
I
I
Institute for the Care of Mother and Child, Prague, Czechoslovakia.
Stirská
K
K
D000293:Adolescent; D000328:Adult; D002648:Child; D002873:Chromosome Fragility; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008875:Middle Aged; D014960:X Chromosome