title: Haploidentical bone marrow transplantation for osteopetrosis.
abstract: HLA-matched bone marrow transplantation is an effective form of treatment for some patients with malignant osteopetrosis, a defect of osteoclast function. Following transplant, normal osteoclasts differentiate from donor-derived marrow stem cells and can function normally in some of these patients. For patients without an HLA-matched marrow donor, pharmacologic treatments have not yet proved effective. This article demonstrates that normal osteoclast function can be obtained following the transplantation of HLA-nonidentical marrow that has been purged of T lymphocytes in vitro.
authors.affiliation: Department of Pediatrics, University of Wisconsin, Madison 53792.
authors.forename: P J
authors.initials: PJ
authors.lastname: Orchard
authors.forename: J D
authors.initials: JD
authors.lastname: Dickerman
authors.forename: C H
authors.initials: CH
authors.lastname: Mathews
authors.forename: S
authors.initials: S
authors.lastname: Frierdich
authors.forename: R
authors.initials: R
authors.lastname: Hong
authors.forename: M E
authors.initials: ME
authors.lastname: Trigg
authors.forename: N T
authors.initials: NT
authors.lastname: Shahidi
authors.forename: J L
authors.initials: JL
authors.lastname: Finlay
authors.forename: P M
authors.initials: PM
authors.lastname: Sondel
mesh_terms: D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D005260:Female; D006680:HLA Antigens; D006239:Haplotypes; D006801:Humans; D007223:Infant; D008212:Lymphocyte Depletion; D010010:Osteoclasts / Q000473:pathology; D010022:Osteopetrosis / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000961:Antilymphocyte Serum; D006680:HLA Antigens