title: Prolonged fever as a presenting symptom in adrenal tumors.
abstract: Four patients with adrenal tumors in whom prolonged fever was the foremost symptom are presented. Two of the patients had nonfunctional adrenocortical carcinoma, one had a pheochromocytoma without adrenergic hyperactivity, and in the fourth, an aldosteronoma was found. Only in 1 case was the tumor (pheochromocytoma) resectable and this patient became afebrile post surgery. A review of the literature revealed that fever is encountered in 6-10% of cases with adrenal tumors, sometimes as the first manifestation of disease. However, a survey of the large series of fever of unknown origin revealed no mention of adrenal tumors in that group of solid tumors which many cause prolonged fever.
authors.affiliation: Rokach (Hadassah) Hospital, Tel-Aviv Medical Center, Israel.
authors.forename: J M
authors.initials: JM
authors.lastname: Klausner
authors.forename: R
authors.initials: R
authors.lastname: Nakash
authors.forename: M
authors.initials: M
authors.lastname: Inbar
authors.forename: M
authors.initials: M
authors.lastname: Gutman
authors.forename: S
authors.initials: S
authors.lastname: Lelcuk
authors.forename: R R
authors.initials: RR
authors.lastname: Rozin
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000503:physiopathology; D000368:Aged; D005260:Female; D005334:Fever / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged