Participation of the serotonin2 receptor in the iminodipropionitrile-induced dyskinetic syndrome.
The effects of the specific serotonin2 antagonist ketanserin on the persistent lateral head shakes, vertical neck dyskinesia, and the random circling behaviors induced by iminodipropionitrile were evaluated. Ketanserin inhibited all these aspects of the behavioral syndrome at all doses tested. These results add further evidence for the involvement of the serotonin system in some of the components of the iminodipropionitrile-induced dyskinetic syndrome.
Cadet
J L
JL
Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, New York 10032.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D007650:Ketanserin / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D009069:Movement Disorders / Q000188:drug therapy* / Q000378:metabolism; D009570:Nitriles; D012701:Serotonin / Q000378:metabolism*; D013035:Spasm / Q000188:drug therapy / Q000378:metabolism
D009570:Nitriles; D012701:Serotonin; C008110:3,3'-iminodipropionitrile; D007650:Ketanserin