title: Familial double testicular tumors: identical chromosome changes in seminoma and embryonal carcinoma of the same testis.
abstract: An identical abnormal chromosome, i(12p), and a marker chromosome of unknown origin were seen in 2 tumors of different histology (seminoma and embryonal carcinoma) in the same testis. A younger brother of the patient also had undergone orchiectomy for 2 seminomas in the left testis 2 years previously. These findings are discussed in relation to the possible cellular background of testicular tumors and their genetic parameters.
authors.affiliation: Veterans Administration Hospital, Phoenix, Arizona.
authors.forename: F S
authors.initials: FS
authors.lastname: Haddad
authors.forename: P M
authors.initials: PM
authors.lastname: Sorini
authors.forename: A A
authors.initials: AA
authors.lastname: Somsin
authors.forename: M H
authors.initials: MH
authors.lastname: Nathan
authors.forename: R M
authors.initials: RM
authors.lastname: Dobbs
authors.forename: C S
authors.initials: CS
authors.lastname: Berger
authors.forename: A A
authors.initials: AA
authors.lastname: Sandberg
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002881:Chromosomes, Human, Pair 12; D004407:Dysgerminoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology; D013724:Teratoma / Q000235:genetics* / Q000473:pathology; D013736:Testicular Neoplasms / Q000235:genetics* / Q000473:pathology; D013737:Testis / Q000473:pathology