title: [Role of 5-bromodeoxyuridine in the formation of sister chromatid exchanges in human lymphocytes exposed to gamma-irradiation at the presynthetic stage of the mitotic cycle].
abstract: The formation of SCE was studied in human lymphocytes irradiated at the presynthetic stage of the cell cycle in the presence or absence of 5-bromodeoxyuridine. The results obtained showed that 5-bromodeoxyuridine present in the culture medium at the time of exposure or during the postirradiation period increased the yield of SCE. It is suggested that 5-bromodeoxyuridine exerts its effect through interfering with DNA repair.
authors.forename: T V
authors.initials: TV
authors.lastname: Kondrashova
mesh_terms: D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects*; D012854:Sister Chromatid Exchange / Q000187:drug effects* / Q000528:radiation effects
chemical_list: D001973:Bromodeoxyuridine
vernacular_title: Rol' 5-bromdezoksiuridina v obrazovanii DKhO pri gamma-obluchenii limfotsitov cheloveka na presinteticheskoĭ stadii mitoticheskogo tsikla.