Glucose depletion hyperpolarizes guinea pig hippocampal neurons by an increase in potassium conductance.
Superfusion of guinea pig hippocampal brain slices with a glucose-free solution induced a membrane hyperpolarization and an increase in input conductance of neurons in the CA3 region. Under voltage clamp, glucose depletion induced an outward current with a reversal potential near the K+ equilibrium potential. The action of glucose depletion was different from the effect of ouabain, indicating that low-glucose-induced changes in the membrane conductance are primarily due to alterations in cell metabolism rather than due only to an inhibition of the Na+/K+ pump.
Spuler
A
A
Department of Physiology, University of Munich, Federal Republic of Germany.
Endres
W
W
Grafe
P
P
D000818:Animals; D004553:Electric Conductivity; D005947:Glucose / Q000378:metabolism*; D006168:Guinea Pigs; D006624:Hippocampus / Q000378:metabolism* / Q000502:physiology; D008564:Membrane Potentials; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D011188:Potassium / Q000502:physiology*
D005947:Glucose; D011188:Potassium