Prostaglandin F2 alpha-1-isopropylester lowers intraocular pressure without decreasing aqueous humor flow.
Using fluorophotometry, we performed a randomized, dose-response study of the effects of a prostaglandin derivative on aqueous humor flow. Prostaglandin F2 alpha 1-isopropylester, 0.224 micrograms, 0.448 micrograms, and 1.120 micrograms, in saline with polysorbate 80 was instilled into one eye of 20 subjects in three separate dose studies. Polysorbate 80 in saline was instilled in the fellow eye as a control. The drug had no measurable effect on aqueous humor flow or corneal endothelial permeability. Intraocular pressure measured eight hours after administration of the highest dose, 1.120 micrograms, was 20% lower in the treated eye as compared to the fellow eye (P less than .001).
Kerstetter
J R
JR
Mayo Medical School, Rochester, Minnesota.
Brubaker
R F
RF
Wilson
S E
SE
Kullerstrand
L J
LJ
D000328:Adult; D001082:Aqueous Humor / Q000187:drug effects* / Q000502:physiology; D015237:Dinoprost / Q000031:analogs & derivatives*; D004728:Endothelium, Corneal / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005454:Fluorescence Polarization; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010539:Permeability; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*
D011461:Prostaglandins F, Synthetic; C041158:prostaglandin F2 isopropyl ester; D015237:Dinoprost