Prevalence of postenteritis cow's milk protein intolerance.
The object of this study was to ascertain the frequency of postinfectious cow's milk protein hypersensitivity (CMPH). Twenty-four infants less than 3 months old were included in the study. Following hospitalization for acute gastroenteritis, the infants were given a protein hydrolysate formula for a period of 6 weeks, after which an intestinal biopsy was performed. Thereafter, a milk challenge was given. The existence of CMPH was defined as a postchallenge reduction of one or more of the mucosal disaccharidases below the normal levels for our laboratory. A bacterial etiology of the gastroenteritis was found in 10. Nineteen infants had no adverse reaction to cow's milk after 6 weeks on a hypoallergenic formula. Only two could be confidently diagnosed as having developed secondary CMPH; both had been infected by Escherichia coli 0 111. One infant had primary CMPH and one extra-intestinal CMPH. The incidence of secondary CMPH with gastrointestinal manifestations in this series was considerably less than described elsewhere.
Hager
C
C
Department of Pediatrics, Central Emek Hospital, Afula, Israel.
Faber
J
J
Kaczuni
A
A
Goldstein
R
R
Levy
E
E
Freier
S
S
D000818:Animals; D003430:Cross-Sectional Studies; D004927:Escherichia coli Infections / Q000150:complications*; D005512:Food Hypersensitivity / Q000453:epidemiology* / Q000209:etiology; D005759:Gastroenteritis / Q000150:complications*; D006801:Humans; D007223:Infant; D007557:Israel; D008892:Milk / Q000009:adverse effects*; D008894:Milk Proteins / Q000009:adverse effects*
D008894:Milk Proteins