title: Lichen sclerosus et atrophicus and autoimmunity--a study of 350 women.
abstract: A study of autoimmune related phenomena in 350 women with histologically confirmed lichen sclerosus et atrophicus revealed that 21.5% had one or more autoimmune related diseases, 21% had one or more first degree relatives with an autoimmune-related disease, 42% had an autoantibody at a titre greater than 1:20, and 59.5% had one or more of these autoimmune-related phenomena. No statistically significant differences in the natural history of lichen sclerosus et atrophicus were demonstrated between those patients with autoimmune-related phenomena and those without.
authors.affiliation: Department of Dermatology, St Bartholomew's Hospital, West Smithfield, London, UK.
authors.forename: R H
authors.initials: RH
authors.lastname: Meyrick Thomas
authors.forename: C M
authors.initials: CM
authors.lastname: Ridley
authors.forename: D H
authors.initials: DH
authors.lastname: McGibbon
authors.forename: M M
authors.initials: MM
authors.lastname: Black
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008875:Middle Aged; D012871:Skin Diseases / Q000276:immunology*
chemical_list: D001323:Autoantibodies