title: Changing expression of ABH blood group and cryptic T-antigens of noninvasive and superficially invasive papillary transitional cell carcinoma of the bladder from initial occurrence to malignant progression.
abstract: Thirteen patients who developed malignant progression after frequent recurrence of noninvasive or superficially invasive (Ta or T1) papillary transitional cell carcinoma of the bladder were studied for expression of ABH-antigens in tumor tissues throughout their clinical courses and cryptic Thomsen-Friedenreich antigen (T-Ag) expression in the tumor tissues was examined simultaneously in nine of them. Five patients who experienced recurrent bladder tumors for more than 5 years without any malignant progression were served as control. ABH-antigens in initial tumors were negative in only two of 13 patients developing malignant progression and in two of five controls. Cryptic T-Ag was positive in all patients examined. Recurrent tumors revealed eliminated or decreased expression of ABH-antigens and cryptic T-Ag before malignant progression in, respectively, ten of 11 and six of nine patients with antigen-positive initial tumors. In contrast, recurrent tumor of controls with antigen-positive initial tumors showed neither elimination nor decrease in expression of antigens throughout their clinical courses.
authors.affiliation: Department of Urology, Tokyo Medical and Dental University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: I
authors.initials: I
authors.lastname: Fukui
authors.forename: M
authors.initials: M
authors.lastname: Yokokawa
authors.forename: H
authors.initials: H
authors.lastname: Oshima
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D002295:Carcinoma, Transitional Cell / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D007519:Isoantigens / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000276:immunology / Q000473:pathology*
chemical_list: D000017:ABO Blood-Group System; D015295:Antigens, Tumor-Associated, Carbohydrate; D007519:Isoantigens; C016467:Thomsen-Friedenreich antigen