Diagnostic and therapeutic applications of antiplatelet monoclonal antibodies.
The interaction of platelets with natural and artificial surfaces is briefly reviewed, emphasizing the role of the platelet glycoprotein Ib and IIb/IIIa receptors. Studies utilizing monoclonal antibodies to these receptors for the diagnosis and therapy of hemorrhagic and thrombotic disorders are described, indicating the potential of such agents as platelet inhibitors.
Coller
B S
BS
Division of Hematology, State University of New York, Stony Brook 11794.
D000818:Animals; D000911:Antibodies, Monoclonal; D001792:Blood Platelets / Q000276:immunology*; D003094:Collagen / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D051379:Mice; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism; D014841:von Willebrand Factor / Q000378:metabolism
D000911:Antibodies, Monoclonal; D010980:Platelet Membrane Glycoproteins; D014841:von Willebrand Factor; D005340:Fibrinogen; D003094:Collagen