title: Tricuspid and mitral regurgitation detected by color flow Doppler in the acute phase of Kawasaki disease.
abstract: Valvular lesions in the acute phase of Kawasaki disease were studied in 19 children. The patients were intensively observed by color flow Doppler every day from the day of hospitalization up to 12 days after the onset of the disease and 2 or more times a week thereafter, for up to 28 days. Mitral regurgitation (MR) was found in 9 patients (47%) and tricuspid regurgitation (TR) in 10 (53%). MRs were of transient type and confirmed from 7.5 +/- 1.6 (mean +/- standard deviation) to 13.1 +/- 6.5 days after the onset of the disease. Both types of valvular regurgitation were mild. The direction of regurgitation was from the center of valvular coaptation toward the posterior wall of the atrium. Neither valvular prolapse nor valvular deformity was noted. In patients with MR, left ventricular ejection fraction on M-mode echocardiography was significantly lower in the acute phase than in the convalescent phase of the disease (p less than 0.05). Using gallium-67 scintigram, the positive uptake of the isotope was noted in 7 (88%) of 8 patients with MR, but not found at all in 8 patients free of MR. These results suggest that MR and TR are often transient in the acute phase of Kawasaki disease and could be attributed to myocarditis.
authors.affiliation: Department of Pediatrics, National Cardiovascular Center, Osaka, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Kamiya
authors.forename: K
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: I
authors.initials: I
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Arakaki
authors.forename: T
authors.initials: T
authors.lastname: Kohata
authors.forename: Y
authors.initials: Y
authors.lastname: Ono
mesh_terms: D000208:Acute Disease; D002306:Cardiac Volume; D002648:Child; D002675:Child, Preschool; D003289:Convalescence; D004452:Echocardiography / Q000379:methods; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D007223:Infant; D008297:Male; D008944:Mitral Valve Insufficiency / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D011877:Radionuclide Imaging; D013318:Stroke Volume; D014262:Tricuspid Valve Insufficiency / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology
chemical_list: D005710:Gallium Radioisotopes