[Studies of 5-FU concentrations associated with microangiography in colorectal cancer tissue].
In order to elucidate the effect of supplying vessels on 5-FU distribution within a tumor, the correlation between 5-FU tissue concentration and tumor microangiography was examined in 31 patients with colorectal cancer after administration of 5-FU (500 mg/day for 3 days). The 5-FU concentration at the tumor margin was significantly higher than that in the other two tissue areas (p less than 0.05). A low 5-FU concentration was noted in the central region of ulcerative cancer showing vertical invasion with vascular disarray and/or histological necrotic foci. This type of tumor also showed a low RNA index by flow cytometry. The present study indicates that the vascular change and vascular pattern of a tumor may be a major contributing factor to 5-FU transfer from the blood circulation into a tumor.
Shimoyama
T
T
1st Dept. of Surgery, Nagasaki University, School of Medicine.
Makiyama
T
T
Fukuda
Y
Y
Kusano
H
H
Kawaguchi
A
A
Shimizu
T
T
Kajiwara
K
K
Mine
Y
Y
Ishikawa
H
H
Tagawa
Y
Y
D000328:Adult; D000368:Aged; D000792:Angiography; D003110:Colonic Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000378:metabolism; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012334:RNA, Neoplasm / Q000032:analysis; D012004:Rectal Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000378:metabolism
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D005472:Fluorouracil