A new autoantibody in patients with rheumatoid arthritis: characterization of the anti-HaT-1 antibody system.
A unique, new autoantibody, anti-HaT-1, has been identified in the serum of patients with rheumatoid arthritis (RA). Anti-HaT-1 antibody is predominantly IgM, and reacts by double immunodiffusion with HaT-1 antigen, an acidic protein in human and rat liver supernatant (MW approximately 150,000). It was detected in 9 of 38 patients with RA, 2 of 15 patients with RA and Sjögren's syndrome, and none of 92 patients with other connective tissue diseases, indicating that this autoantibody is highly specific for RA.
Abe
Y
Y
Department of Internal Medicine, School of Medicine, Fujita-Gakuen Health University, Aichi, Japan.
Inada
S
S
Torikai
K
K
D000918:Antibody Specificity; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D003240:Connective Tissue Diseases / Q000276:immunology; D006801:Humans; D009928:Organ Specificity; D013045:Species Specificity
D001323:Autoantibodies