[Effect of a food ration with a low-protein content on the processes of liver parenchyma recovery in rats after tetrachloromethane damage].
Male Wistar rats weighing 190-200 g were fed a low protein diet. Atrophy of cytoplasm was observed after a 3-week malnutrition. In early periods of liver regeneration (6 hr after CCl4 poisoning), an increase in DNA synthesis was accompanied by an increase in summary concentration of organelle membranes. Though their ploidy was higher than in the control, volume of hepatocytes and summary area of organelles surface membrane was smaller than in standard diet. These data show a reduced capacity for realization of genetic program during the regeneration period in protein-deficient rats.
Shorina
G N
GN
Bgatova
N P
NP
Simek
J
J
Cervinková
Z
Z
Holecek
M
M
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002252:Carbon Tetrachloride Poisoning / Q000178:diet therapy / Q000378:metabolism / Q000473:pathology; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D004044:Dietary Proteins / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D011003:Ploidies / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004044:Dietary Proteins; D004247:DNA; D002251:Carbon Tetrachloride
Vliianie pishchevogo ratsiona s nizkim soderzhaniem belka na protsessy vosstanovleniia parenkhimy pecheni krys posle povrezhdeniia tetrachlormetanom.